Sample records for lead 195

  1. 49 CFR 195.567 - Which pipelines must have test leads and what must I do to install and maintain the leads?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Corrosion Control § 195.567 Which pipelines must have test leads and what must I do to install and maintain... corrosion control. However, this requirement does not apply until December 27, 2004 to pipelines or pipeline...

  2. 49 CFR 195.567 - Which pipelines must have test leads and what must I do to install and maintain the leads?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Corrosion Control § 195.567 Which pipelines must have test leads and what must I do to install and maintain... corrosion control. However, this requirement does not apply until December 27, 2004 to pipelines or pipeline...

  3. 49 CFR 195.567 - Which pipelines must have test leads and what must I do to install and maintain the leads?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Corrosion Control § 195.567 Which pipelines must have test leads and what must I do to install and maintain... corrosion control. However, this requirement does not apply until December 27, 2004 to pipelines or pipeline...

  4. 49 CFR 195.567 - Which pipelines must have test leads and what must I do to install and maintain the leads?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Corrosion Control § 195.567 Which pipelines must have test leads and what must I do to install and maintain... corrosion control. However, this requirement does not apply until December 27, 2004 to pipelines or pipeline...

  5. The line-locking hypothesis, absorption by intervening galaxies, and the z = 1.95 peak in redshifts

    NASA Technical Reports Server (NTRS)

    Burbidge, G.

    1978-01-01

    The controversy over whether the absorption spectrum in QSOs is intrinsic or extrinsic is approached with attention to the peak of redshifts at z = 1.95. Also considered are the line-locking and the intervening galaxy hypotheses. The line locking hypothesis is based on observations that certain ratios found in absorption line QSOs are preferred, and leads inevitably to the conclusion that the absorption line systems are intrinsic. The intervening galaxy hypothesis is based on absorption redshifts resulting from given absorption cross-sections of galactic clusters and the intergalactic medium, and would lead to the theoretical conclusion that most QSOs show strong absorption, a conclusion which is not supported by empirical data. The 1.95 peak, on the other hand, is most probably an intrinsic property of QSOs. The peak is enhanced by redshift, and it is noted that both an emission and an absorption redshift peak are seen at 1.95.

  6. 49 CFR 195.567 - Which pipelines must have test leads and what must I do to install and maintain the leads?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... segments on which test leads were not required by regulations in effect before January 28, 2002. (b... or slack so backfilling will not unduly stress or break the lead and the lead will otherwise remain mechanically secure and electrically conductive. (3) Prevent lead attachments from causing stress...

  7. Evaluation of robenidine analog NCL195 as a novel broad-spectrum antibacterial agent.

    PubMed

    Ogunniyi, Abiodun D; Khazandi, Manouchehr; Stevens, Andrew J; Sims, Sarah K; Page, Stephen W; Garg, Sanjay; Venter, Henrietta; Powell, Andrew; White, Karen; Petrovski, Kiro R; Laven-Law, Geraldine; Tótoli, Eliane G; Salgado, Hérida R; Pi, Hongfei; Coombs, Geoffrey W; Shinabarger, Dean L; Turnidge, John D; Paton, James C; McCluskey, Adam; Trott, Darren J

    2017-01-01

    The spread of multidrug resistance among bacterial pathogens poses a serious threat to public health worldwide. Recent approaches towards combating antimicrobial resistance include repurposing old compounds with known safety and development pathways as new antibacterial classes with novel mechanisms of action. Here we show that an analog of the anticoccidial drug robenidine (4,6-bis(2-((E)-4-methylbenzylidene)hydrazinyl)pyrimidin-2-amine; NCL195) displays potent bactericidal activity against Streptococcus pneumoniae and Staphylococcus aureus by disrupting the cell membrane potential. NCL195 was less cytotoxic to mammalian cell lines than the parent compound, showed low metabolic degradation rates by human and mouse liver microsomes, and exhibited high plasma concentration and low plasma clearance rates in mice. NCL195 was bactericidal against Acinetobacter spp and Neisseria meningitidis and also demonstrated potent activity against A. baumannii, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Enterobacter spp. in the presence of sub-inhibitory concentrations of ethylenediaminetetraacetic acid (EDTA) and polymyxin B. These findings demonstrate that NCL195 represents a new chemical lead for further medicinal chemistry and pharmaceutical development to enhance potency, solubility and selectivity against serious bacterial pathogens.

  8. Evaluation of robenidine analog NCL195 as a novel broad-spectrum antibacterial agent

    PubMed Central

    Sims, Sarah K.; Page, Stephen W.; Garg, Sanjay; Venter, Henrietta; Powell, Andrew; White, Karen; Petrovski, Kiro R.; Laven-Law, Geraldine; Tótoli, Eliane G.; Salgado, Hérida R.; Pi, Hongfei; Coombs, Geoffrey W.; Shinabarger, Dean L.; Turnidge, John D.; Paton, James C.; McCluskey, Adam; Trott, Darren J.

    2017-01-01

    The spread of multidrug resistance among bacterial pathogens poses a serious threat to public health worldwide. Recent approaches towards combating antimicrobial resistance include repurposing old compounds with known safety and development pathways as new antibacterial classes with novel mechanisms of action. Here we show that an analog of the anticoccidial drug robenidine (4,6-bis(2-((E)-4-methylbenzylidene)hydrazinyl)pyrimidin-2-amine; NCL195) displays potent bactericidal activity against Streptococcus pneumoniae and Staphylococcus aureus by disrupting the cell membrane potential. NCL195 was less cytotoxic to mammalian cell lines than the parent compound, showed low metabolic degradation rates by human and mouse liver microsomes, and exhibited high plasma concentration and low plasma clearance rates in mice. NCL195 was bactericidal against Acinetobacter spp and Neisseria meningitidis and also demonstrated potent activity against A. baumannii, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Enterobacter spp. in the presence of sub-inhibitory concentrations of ethylenediaminetetraacetic acid (EDTA) and polymyxin B. These findings demonstrate that NCL195 represents a new chemical lead for further medicinal chemistry and pharmaceutical development to enhance potency, solubility and selectivity against serious bacterial pathogens. PMID:28873428

  9. 40 CFR 421.256 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... for any 1 day Maximum for monthly average mg/troy ounce of gold refined electrolytically Lead 5.544 2... Maximum for monthly average mg/troy ounce of gold and silver smelted Lead 0.364 0.169 Mercury 0.195 0.078... Maximum for monthly average mg/troy ounce of silver reduced in solution Lead 0.112 0.052 Mercury 0.060 0...

  10. 40 CFR 421.256 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Maximum for monthly average mg/troy ounce of gold and silver smelted Lead 0.364 0.169 Mercury 0.195 0.078... Maximum for monthly average mg/troy ounce of silver reduced in solution Lead 0.112 0.052 Mercury 0.060 0... for any 1 day Maximum for monthly average mg/troy ounce of gold refined electrolytically Lead 5.544 2...

  11. 40 CFR 421.253 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... gold refined electrolytically Lead 5.544 2.574 Mercury 2.970 1.188 Silver 5.742 2.376 Zinc 20.200 8.316... smelted Lead 0.364 0.169 Mercury 0.195 0.078 Silver 0.377 0.156 Zinc 1.326 0.546 Gold 0.130 (b) Silver... reduced in solution Lead 0.112 0.052 Mercury 0.060 0.024 Silver 0.116 0.048 Zinc 0.408 0.168 Gold 0.040 (c...

  12. Structure-function relationships for the selective inhibition of human 3β-hydroxysteroid dehydrogenase type 1 by a novel androgen analog.

    PubMed

    Pham, Jenny H; Will, Catherine M; Mack, Vance L; Halbert, Matthew; Conner, Edward Alexander; Bucholtz, Kevin M; Thomas, James L

    2017-11-01

    3β-Hydroxysteroid dehydrogenase type 1 (3β-HSD1) is selectively expressed in human placenta, mammary glands and breast tumors in women. Human 3β-HSD2 is selectively expressed in adrenal glands and ovaries. Based on AutoDock 3 and 4 results, we have exploited key differences in the amino acid sequences of 3β-HSD1 (Ser194, Arg195) and 3β-HSD2 (Gly194, Pro195) by designing a selective inhibitor of 3β-HSD1. 2,16-Dicyano-4,5-epoxy-androstane-3,17-dione (16-cyano-17-keto-trilostane or DiCN-AND) was synthesized in a 4-step procedure from androstenedione. In purified 3β-HSD inhibition studies, DiCN-AND competitively inhibited 3β- HSD1 with K i =4.7μM and noncompetitively inhibited 3β-HSD2 with a 6.5-fold higher K i =30.7μM. We previously reported similar isoenzyme-specific inhibition profiles for trilostane. Based on our docking results, we created, expressed and purified the chimeric S194G-1 mutant of 3β-HSD1. Trilostane inhibited S194G-1 (K i =0.67μM) with a noncompetitive mode compared to its 6.7-fold higher affinity, competitive inhibition of 3β-HSD1 (K i =0.10μM). DiCN-AND inhibited S194G-1 with a 6.3-fold higher K i (29.5μM) than measured for 3β-HSD1 (K i =4.7μM) but with the same competitive mode for both enzyme species. Since DiCN-AND noncompetitively inhibits 3β-HSD2, which has the Gly194 and Pro195 of 3β-HSD2 in place of the Ser194 and Arg195 in 3β-HSD1, this suggests that Arg195 alone in 3β-HSD1 or S194G-1 is required to bind DiCN-AND in the substrate binding site (competitive inhibition). However, both Ser194 and Arg195 are required to bind trilostane in the 3β-HSD1 substrate site based on its noncompetitive inhibition of S194G-1 and 3β-HSD2. In support of this hypothesis, DiCN-AND inhibited our chimeric R195P-1 mutant noncompetitively with a K i =41.3μM (similar to the 3β-HSD2 inhibition profile). Since DiCN-AND competitively inhibited S194G-1 that still contains R195 but noncompetitively inhibited R195P-1 that still contains S194, our data provides strong evidence that the Arg195 being mutated to Pro195 (as present in 3β-HSD2) shifts the inhibition mode from competitive to noncompetitive in 3β-HSD1. This supports the key role of Arg195 in 3β-HSD1 for the high affinity, competitive binding of the trilostane analogs. Our new structure/function information for the design of targeted 3β-HSD1 inhibitors may lead to important new treatments for the prevention of spontaneous premature birth. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. 40 CFR 421.253 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... pollutant property Maximum for any 1 day Maximum for monthly average mg/troy ounce of gold and silver smelted Lead 0.364 0.169 Mercury 0.195 0.078 Silver 0.377 0.156 Zinc 1.326 0.546 Gold 0.130 (b) Silver... reduced in solution Lead 0.112 0.052 Mercury 0.060 0.024 Silver 0.116 0.048 Zinc 0.408 0.168 Gold 0.040 (c...

  14. 40 CFR 421.253 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... pollutant property Maximum for any 1 day Maximum for monthly average mg/troy ounce of gold and silver smelted Lead 0.364 0.169 Mercury 0.195 0.078 Silver 0.377 0.156 Zinc 1.326 0.546 Gold 0.130 (b) Silver... reduced in solution Lead 0.112 0.052 Mercury 0.060 0.024 Silver 0.116 0.048 Zinc 0.408 0.168 Gold 0.040 (c...

  15. 40 CFR 421.253 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... pollutant property Maximum for any 1 day Maximum for monthly average mg/troy ounce of gold and silver smelted Lead 0.364 0.169 Mercury 0.195 0.078 Silver 0.377 0.156 Zinc 1.326 0.546 Gold 0.130 (b) Silver... reduced in solution Lead 0.112 0.052 Mercury 0.060 0.024 Silver 0.116 0.048 Zinc 0.408 0.168 Gold 0.040 (c...

  16. 40 CFR 468.11 - Effluent limitations representing the degree of effluent reduction attainable by the application...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of copper or copper alloy hot rolled Chromium 0.045 0.018 Copper 0.195 0.103 Lead 0.015 0.013 Nickel... alloy cold rolled Chromium 0.166 0.068 Copper 0.720 0.379 Lead 0.056 0.049 Nickel 0.727 0.481 Zinc 0.553... drawn English units—pounds per 1,000,000 off-pounds of copper or copper alloy drawn Chromium 0.037 0.015...

  17. 40 CFR 468.11 - Effluent limitations representing the degree of effluent reduction attainable by the application...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of copper or copper alloy hot rolled Chromium 0.045 0.018 Copper 0.195 0.103 Lead 0.015 0.013 Nickel... alloy cold rolled Chromium 0.166 0.068 Copper 0.720 0.379 Lead 0.056 0.049 Nickel 0.727 0.481 Zinc 0.553... drawn English units—pounds per 1,000,000 off-pounds of copper or copper alloy drawn Chromium 0.037 0.015...

  18. 40 CFR 468.11 - Effluent limitations representing the degree of effluent reduction attainable by the application...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of copper or copper alloy hot rolled Chromium 0.045 0.018 Copper 0.195 0.103 Lead 0.015 0.013 Nickel... alloy cold rolled Chromium 0.166 0.068 Copper 0.720 0.379 Lead 0.056 0.049 Nickel 0.727 0.481 Zinc 0.553... drawn English units—pounds per 1,000,000 off-pounds of copper or copper alloy drawn Chromium 0.037 0.015...

  19. 40 CFR 468.11 - Effluent limitations representing the degree of effluent reduction attainable by the application...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of copper or copper alloy hot rolled Chromium 0.045 0.018 Copper 0.195 0.103 Lead 0.015 0.013 Nickel... alloy cold rolled Chromium 0.166 0.068 Copper 0.720 0.379 Lead 0.056 0.049 Nickel 0.727 0.481 Zinc 0.553... drawn English units—pounds per 1,000,000 off-pounds of copper or copper alloy drawn Chromium 0.037 0.015...

  20. The first X-45A Unmanned Combat Air Vehicle (UCAV) technology demonstrator completed its sixth flight on Dec. 19, 2002, raising its landing gear in flight for the first time. The X-45A flew for 40 minutes and reached an airspeed of 195 knots

    NASA Image and Video Library

    2002-12-19

    The first X-45A Unmanned Combat Air Vehicle (UCAV) technology demonstrator completed its sixth flight on Dec. 19, 2002, raising its landing gear in flight for the first time. The X-45A flew for 40 minutes and reached an airspeed of 195 knots and an altitude of 7,500 feet. Dryden is supporting the DARPA/Boeing team in the design, development, integration, and demonstration of the critical technologies, processes, and system attributes leading to an operational UCAV system. Dryden support of the X-45A demonstrator system includes analysis, component development, simulations, ground and flight tests.

  1. MicroRNA-195 inhibits proliferation of cervical cancer cells by targeting cyclin D1a.

    PubMed

    Wang, Ning; Wei, Heng; Yin, Duo; Lu, Yanming; Zhang, Yao; Zhang, Qiao; Ma, Xiaoxin; Zhang, Shulan

    2016-04-01

    Cervical cancer is one of the most frequent gynecological malignancies in women worldwide. MicroRNA-195 (miR-195) was recently found highly expressed in cervical cancer. However, the role of miR-195 in the pathology of cervical cancer remains poorly understood. In this study, we first confirmed the downregulation of miR-195 in primary cervical cancer tissues. For the functional study, we introduced the sequences of miR-195 or miR-195 inhibitor into Hela and SiHa cervical cancer cell lines. Overexpression of miR-195 inhibited the proliferation of both Hela and SiHa cells. In contrast, reducing the endogenous miR-195 level by miR-195 inhibitor promoted the proliferation of cervical cancer cells. Flow cytometric assay showed that overexpression of miR-195 induced G1 phase arrest, whereas miR-195 inhibitor shortened G1 phase of cervical cancer cells. In addition, the suppressive role of miR-195 in cell cycle was also demonstrated by the western blot results of various cell cycle indicators, such as phosphorylated retinoblastoma (p-Rb) and proliferating cell nuclear antigen (PCNA), in the gain and loss of function experiments. Furthermore, Dual-Luciferase Reporter Assay revealed that miR-195 targeted the 3'-untranslated region of cyclin D1a transcript, such as to regulate cyclin D1 expression. In summary, our results suggest that miR-195 acts as a suppressor in the proliferation and cell cycle of cervical cancer cells by directly targeting cyclin D1a mRNA.

  2. Hyperthermia enhances mapatumumab-induced apoptotic death through ubiquitin-mediated degradation of cellular FLIP(long) in human colon cancer cells

    PubMed Central

    Song, X; Kim, S-Y; Zhou, Z; Lagasse, E; Kwon, Y T; Lee, Y J

    2013-01-01

    Colorectal cancer is the third leading cause of cancer-related mortality in the world; the main cause of death of colorectal cancer is hepatic metastases, which can be treated with hyperthermia using isolated hepatic perfusion (IHP). In this study, we report that mild hyperthermia potently reduced cellular FLIP(long), (c-FLIPL), a major regulator of the death receptor (DR) pathway of apoptosis, thereby enhancing humanized anti-DR4 antibody mapatumumab (Mapa)-mediated mitochondria-independent apoptosis. We observed that overexpression of c-FLIPL in CX-1 cells abrogated the synergistic effect of Mapa and hyperthermia, whereas silencing of c-FLIP in CX-1 cells enhanced Mapa-induced apoptosis. Hyperthermia altered c-FLIPL protein stability without concomitant reductions in FLIP mRNA. Ubiquitination of c-FLIPL was increased by hyperthermia, and proteasome inhibitor MG132 prevented heat-induced downregulation of c-FLIPL. These results suggest the involvement of the ubiquitin-proteasome system in this process. We also found lysine residue 195 (K195) to be essential for c-FLIPL ubiquitination and proteolysis, as mutant c-FLIPL lysine 195 arginine (arginine replacing lysine) was left virtually un-ubiquitinated and was refractory to hyperthermia-triggered degradation, and thus partially blocked the synergistic effect of Mapa and hyperthermia. Our observations reveal that hyperthermia transiently reduced c-FLIPL by proteolysis linked to K195 ubiquitination, which contributed to the synergistic effect between Mapa and hyperthermia. This study supports the application of hyperthermia combined with other regimens to treat colorectal hepatic metastases. PMID:23559011

  3. Hyperthermia enhances mapatumumab-induced apoptotic death through ubiquitin-mediated degradation of cellular FLIP(long) in human colon cancer cells.

    PubMed

    Song, X; Kim, S-Y; Zhou, Z; Lagasse, E; Kwon, Y T; Lee, Y J

    2013-04-04

    Colorectal cancer is the third leading cause of cancer-related mortality in the world; the main cause of death of colorectal cancer is hepatic metastases, which can be treated with hyperthermia using isolated hepatic perfusion (IHP). In this study, we report that mild hyperthermia potently reduced cellular FLIP(long), (c-FLIP(L)), a major regulator of the death receptor (DR) pathway of apoptosis, thereby enhancing humanized anti-DR4 antibody mapatumumab (Mapa)-mediated mitochondria-independent apoptosis. We observed that overexpression of c-FLIP(L) in CX-1 cells abrogated the synergistic effect of Mapa and hyperthermia, whereas silencing of c-FLIP in CX-1 cells enhanced Mapa-induced apoptosis. Hyperthermia altered c-FLIP(L) protein stability without concomitant reductions in FLIP mRNA. Ubiquitination of c-FLIP(L) was increased by hyperthermia, and proteasome inhibitor MG132 prevented heat-induced downregulation of c-FLIP(L). These results suggest the involvement of the ubiquitin-proteasome system in this process. We also found lysine residue 195 (K195) to be essential for c-FLIP(L) ubiquitination and proteolysis, as mutant c-FLIP(L) lysine 195 arginine (arginine replacing lysine) was left virtually un-ubiquitinated and was refractory to hyperthermia-triggered degradation, and thus partially blocked the synergistic effect of Mapa and hyperthermia. Our observations reveal that hyperthermia transiently reduced c-FLIP(L) by proteolysis linked to K195 ubiquitination, which contributed to the synergistic effect between Mapa and hyperthermia. This study supports the application of hyperthermia combined with other regimens to treat colorectal hepatic metastases.

  4. 49 CFR 195.111 - Fracture propagation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Fracture propagation. 195.111 Section 195.111... PIPELINE Design Requirements § 195.111 Fracture propagation. A carbon dioxide pipeline system must be designed to mitigate the effects of fracture propagation. [Amdt. 195-45, 56 FR 26926, June 12, 1991] ...

  5. 49 CFR 195.111 - Fracture propagation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Fracture propagation. 195.111 Section 195.111... PIPELINE Design Requirements § 195.111 Fracture propagation. A carbon dioxide pipeline system must be designed to mitigate the effects of fracture propagation. [Amdt. 195-45, 56 FR 26926, June 12, 1991] ...

  6. 49 CFR 195.111 - Fracture propagation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Fracture propagation. 195.111 Section 195.111... PIPELINE Design Requirements § 195.111 Fracture propagation. A carbon dioxide pipeline system must be designed to mitigate the effects of fracture propagation. [Amdt. 195-45, 56 FR 26926, June 12, 1991] ...

  7. 49 CFR 195.111 - Fracture propagation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Fracture propagation. 195.111 Section 195.111... PIPELINE Design Requirements § 195.111 Fracture propagation. A carbon dioxide pipeline system must be designed to mitigate the effects of fracture propagation. [Amdt. 195-45, 56 FR 26926, June 12, 1991] ...

  8. 49 CFR 195.111 - Fracture propagation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Fracture propagation. 195.111 Section 195.111... PIPELINE Design Requirements § 195.111 Fracture propagation. A carbon dioxide pipeline system must be designed to mitigate the effects of fracture propagation. [Amdt. 195-45, 56 FR 26926, June 12, 1991] ...

  9. 49 CFR 195.54 - Accident reports.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Accident reports. 195.54 Section 195.54... PIPELINE Annual, Accident, and Safety-Related Condition Reporting § 195.54 Accident reports. (a) Each operator that experiences an accident that is required to be reported under § 195.50 shall as soon as...

  10. 49 CFR 195.48 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 195.48 Section 195.48 Transportation Other... Annual, Accident, and Safety-Related Condition Reporting § 195.48 Scope. This subpart prescribes... 7000-1.1) required by § 195.49 or to provide the estimate of total miles that could affect high...

  11. Correlation between some parameters of lead absorption and lead intoxication

    PubMed Central

    Waldron, H. A.

    1971-01-01

    Waldron, H. A. (1971).Brit. J. industr. Med.,28, 195-199. Correlation between some parameters of lead absorption and lead intoxication. Use has been made of data collected over a number of years from workers exposed to a lead hazard in a motor-car factory. The correlations between various parameters of lead absorption and lead intoxication were computed, including blood and urine lead concentrations, urinary coproporphyrin, ALA and PBG concentrations, and haemoglobin concentration. In all, 15 correlation coefficients were calculated, of which only six showed a statistically significant result (i.e., P<0·05). These six were blood lead and urine lead (r = 0·38, P<0·001), urine lead and coproporphyrin (r = 0·42, P<0·001), urine lead and ALA (r = 0·43, P<0·001), coproporphyrin and ALA (r = 0·75, P<0·001), ALA and PBG (r = 0·49, P<0·001), and urine lead and PBG (r = 0·19, P<0·05). PMID:5572689

  12. γT -S195A thrombin reduces the anticoagulant effects of dabigatran in vitro and in vivo.

    PubMed

    Sheffield, W P; Lambourne, M D; Eltringham-Smith, L J; Bhakta, V; Arnold, D M; Crowther, M A

    2014-07-01

    Dabigatran etexilate (DE) is an oral direct thrombin inhibitor used to prevent strokes in patients with atrial fibrillation. No licensed DE antidote is currently available. We hypothesized that active site-mutated S195A thrombin (S195A-IIa) and/or its trypsinized derivative (γT -S195A-IIa) would sequester dabigatran, the active form of DE, and reduce its anticoagulant effects. To assess active site-mutated S195A or γT -S195A-IIa as dabigatran reversal agents in vitro and in vivo. Diluted thrombin time (dTT) assays were performed using human or murine plasma containing dabigatran, combined with S195A-IIa, γT -S195A-IIa or FPR-chloromethyl ketone-treated thrombin (FPR-IIa). Bleeding times were determined in anesthetized DE-treated mice also receiving γT -S195A-IIa or vehicle 15 min prior to tail transection. The time to occlusion of carotid arteries of DE-treated mice also receiving S195A-IIa, γT -S195A-IIa, prothrombin complex concentrate (PCC) or vehicle, 15 min prior to topical FeCl3 , was determined using Doppler ultrasound. γT-S195A-IIa reduced dTT values of dabigatran-containing human and murine plasma more effectively than S195-IIa; FPR-IIa had no effect. A dose of 13 mg kg(-1) DE abrogated occlusive thrombus formation in the carotid arteries of FeCl3 -treated mice; γT -S195A-IIa (6 mg kg(-1) ) or PCC (14.3 IU kg(-1) ), but not saline vehicle or S195A-IIa (6 mg kg(-1) ), was equally effective in restoring thrombus formation. Bleeding times of mice treated with 60 mg kg(-1) DE and γT -S195A-IIa (6 mg kg(-1) ) or saline vehicle did not differ. Our data suggest that γT -S195A-IIa decreases the anticoagulant effects of dabigatran in vitro and is partially effective at restoring hemostasis-related thrombus formation in DE-treated mice in vivo. © 2014 International Society on Thrombosis and Haemostasis.

  13. 40 CFR 421.256 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Maximum for monthly average mg/troy ounce of gold and silver smelted Lead 0.364 0.169 Mercury 0.195 0.078 Silver 0.377 0.156 Zinc 1.326 0.546 Gold 0.130 (b) Silver chloride reduction spent solution. PSNS for the....024 Silver 0.116 0.048 Zinc 0.408 0.168 Gold 0.040 (c) Electrolytic cells wet air pollution control...

  14. 40 CFR 421.256 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Maximum for monthly average mg/troy ounce of gold and silver smelted Lead 0.364 0.169 Mercury 0.195 0.078 Silver 0.377 0.156 Zinc 1.326 0.546 Gold 0.130 (b) Silver chloride reduction spent solution. PSNS for the....024 Silver 0.116 0.048 Zinc 0.408 0.168 Gold 0.040 (c) Electrolytic cells wet air pollution control...

  15. 40 CFR 421.256 - Pretreatment standards for new sources.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Maximum for monthly average mg/troy ounce of gold and silver smelted Lead 0.364 0.169 Mercury 0.195 0.078 Silver 0.377 0.156 Zinc 1.326 0.546 Gold 0.130 (b) Silver chloride reduction spent solution. PSNS for the....024 Silver 0.116 0.048 Zinc 0.408 0.168 Gold 0.040 (c) Electrolytic cells wet air pollution control...

  16. 49 CFR 195.222 - Welders: Qualification of welders.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... be qualified in accordance with section 6 of API 1104 (incorporated by reference, see § 195.3) or... and found acceptable under section 9 of API 1104 (incorporated by reference, see § 195.3). [Amdt. 195...

  17. 49 CFR 195.222 - Welders: Qualification of welders.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... be qualified in accordance with section 6 of API 1104 (incorporated by reference, see § 195.3) or... and found acceptable under section 9 of API 1104 (incorporated by reference, see § 195.3). [Amdt. 195...

  18. 49 CFR 195.222 - Welders: Qualification of welders.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... be qualified in accordance with section 6 of API 1104 (incorporated by reference, see § 195.3) or... and found acceptable under section 9 of API 1104 (incorporated by reference, see § 195.3). [Amdt. 195...

  19. 49 CFR 195.207 - Transportation of pipe.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... in accordance with API Recommended Practice 5L1 (incorporated by reference, see § 195.3). (b) Ship or... with API Recommended Practice 5LW (incorporated by reference, see § 195.3). [ Amdt. 195-94, 75 FR 48606...

  20. 49 CFR 195.222 - Welders: Qualification of welders.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... be qualified in accordance with section 6 of API 1104 (incorporated by reference, see § 195.3) or... and found acceptable under section 9 of API 1104 (incorporated by reference, see § 195.3). [Amdt. 195...

  1. 49 CFR 195.207 - Transportation of pipe.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... in accordance with API Recommended Practice 5L1 (incorporated by reference, see § 195.3). (b) Ship or... with API Recommended Practice 5LW (incorporated by reference, see § 195.3). [ Amdt. 195-94, 75 FR 48606...

  2. 7 CFR 800.195 - Delegations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false Delegations. 800.195 Section 800.195 Agriculture... ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE), DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS Delegations, Designations, Approvals, Contracts, and Conflicts of Interest § 800.195 Delegations. (a) General. Eligible...

  3. 7 CFR 800.195 - Delegations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Delegations. 800.195 Section 800.195 Agriculture... ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE), DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS Delegations, Designations, Approvals, Contracts, and Conflicts of Interest § 800.195 Delegations. (a) General. Eligible...

  4. 40 CFR 68.195 - Required corrections.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 15 2011-07-01 2011-07-01 false Required corrections. 68.195 Section 68.195 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.195 Required corrections. The owner or...

  5. 49 CFR 195.266 - Construction records.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Construction records. 195.266 Section 195.266 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.266 Construction records. A complete record that shows the following must be...

  6. 49 CFR 195.266 - Construction records.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Construction records. 195.266 Section 195.266 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.266 Construction records. A complete record that shows the following must be...

  7. 49 CFR 195.130 - Fabricated assemblies.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Fabricated assemblies. 195.130 Section 195.130 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Design Requirements § 195.130 Fabricated assemblies. Each fabricated assembly to be installed in a...

  8. 49 CFR 195.130 - Fabricated assemblies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Fabricated assemblies. 195.130 Section 195.130 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Design Requirements § 195.130 Fabricated assemblies. Each fabricated assembly to be installed in a...

  9. 49 CFR 195.130 - Fabricated assemblies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Fabricated assemblies. 195.130 Section 195.130 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Design Requirements § 195.130 Fabricated assemblies. Each fabricated assembly to be installed in a...

  10. 49 CFR 195.130 - Fabricated assemblies.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Fabricated assemblies. 195.130 Section 195.130 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Design Requirements § 195.130 Fabricated assemblies. Each fabricated assembly to be installed in a...

  11. 49 CFR 195.130 - Fabricated assemblies.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Fabricated assemblies. 195.130 Section 195.130 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Design Requirements § 195.130 Fabricated assemblies. Each fabricated assembly to be installed in a...

  12. 49 CFR 195.224 - Welding: Weather.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welding: Weather. 195.224 Section 195.224 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.224 Welding: Weather. Welding must be protected from weather conditions that...

  13. 49 CFR 195.102 - Design temperature.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Design temperature. 195.102 Section 195.102 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Design Requirements § 195.102 Design temperature. (a) Material for components of the system must...

  14. 49 CFR 195.102 - Design temperature.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Design temperature. 195.102 Section 195.102 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Design Requirements § 195.102 Design temperature. (a) Material for components of the system must...

  15. 49 CFR 195.50 - Reporting accidents.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Reporting accidents. 195.50 Section 195.50 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Annual, Accident, and Safety-Related Condition Reporting § 195.50 Reporting accidents. An accident...

  16. 49 CFR 195.50 - Reporting accidents.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Reporting accidents. 195.50 Section 195.50 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Annual, Accident, and Safety-Related Condition Reporting § 195.50 Reporting accidents. An accident...

  17. 49 CFR 195.124 - Closures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Closures. 195.124 Section 195.124 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.124...

  18. 49 CFR 195.124 - Closures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Closures. 195.124 Section 195.124 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.124...

  19. 49 CFR 195.124 - Closures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Closures. 195.124 Section 195.124 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.124...

  20. 49 CFR 195.124 - Closures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Closures. 195.124 Section 195.124 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.124...

  1. 49 CFR 195.124 - Closures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Closures. 195.124 Section 195.124 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.124...

  2. 49 CFR 195.224 - Welding: Weather.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Welding: Weather. 195.224 Section 195.224 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.224 Welding: Weather. Welding must be protected from weather conditions that...

  3. 49 CFR 195.224 - Welding: Weather.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Welding: Weather. 195.224 Section 195.224 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.224 Welding: Weather. Welding must be protected from weather conditions that...

  4. 49 CFR 195.224 - Welding: Weather.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Welding: Weather. 195.224 Section 195.224 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.224 Welding: Weather. Welding must be protected from weather conditions that...

  5. 49 CFR 195.224 - Welding: Weather.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Welding: Weather. 195.224 Section 195.224 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.224 Welding: Weather. Welding must be protected from weather conditions that...

  6. 40 CFR 68.195 - Required corrections.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Required corrections. 68.195 Section 68.195 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.195 Required corrections. The owner or...

  7. 49 CFR 195.408 - Communications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Communications. 195.408 Section 195.408... PIPELINE Operation and Maintenance § 195.408 Communications. (a) Each operator must have a communication... system. (b) The communication system required by paragraph (a) of this section must, as a minimum...

  8. 49 CFR 195.408 - Communications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Communications. 195.408 Section 195.408... PIPELINE Operation and Maintenance § 195.408 Communications. (a) Each operator must have a communication... system. (b) The communication system required by paragraph (a) of this section must, as a minimum...

  9. 49 CFR 195.426 - Scraper and sphere facilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Scraper and sphere facilities. 195.426 Section 195.426 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... HAZARDOUS LIQUIDS BY PIPELINE Operation and Maintenance § 195.426 Scraper and sphere facilities. No operator...

  10. 49 CFR 195.262 - Pumping equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Pumping equipment. 195.262 Section 195.262... PIPELINE Construction § 195.262 Pumping equipment. (a) Adequate ventilation must be provided in pump... provided in each pump station: (1) Safety devices that prevent overpressuring of pumping equipment...

  11. 49 CFR 195.444 - CPM leak detection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false CPM leak detection. 195.444 Section 195.444... PIPELINE Operation and Maintenance § 195.444 CPM leak detection. Each computational pipeline monitoring (CPM) leak detection system installed on a hazardous liquid pipeline transporting liquid in single...

  12. 49 CFR 195.206 - Material inspection.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Material inspection. 195.206 Section 195.206 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.206 Material inspection. No pipe or other component may be installed in a...

  13. 49 CFR 195.206 - Material inspection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Material inspection. 195.206 Section 195.206 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.206 Material inspection. No pipe or other component may be installed in a...

  14. 49 CFR 195.216 - Welding: Miter joints.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welding: Miter joints. 195.216 Section 195.216 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.216 Welding: Miter joints. A miter joint is not permitted (not including...

  15. 49 CFR 195.108 - External pressure.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false External pressure. 195.108 Section 195.108... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.108 External pressure. Any external pressure that will be exerted on the...

  16. 49 CFR 195.108 - External pressure.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false External pressure. 195.108 Section 195.108... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.108 External pressure. Any external pressure that will be exerted on the...

  17. 49 CFR 195.108 - External pressure.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false External pressure. 195.108 Section 195.108... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.108 External pressure. Any external pressure that will be exerted on the...

  18. 49 CFR 195.304 - Test pressure.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Test pressure. 195.304 Section 195.304... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.304 Test pressure. The test pressure for each pressure test conducted under...

  19. 49 CFR 195.108 - External pressure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false External pressure. 195.108 Section 195.108... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.108 External pressure. Any external pressure that will be exerted on the...

  20. 49 CFR 195.304 - Test pressure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Test pressure. 195.304 Section 195.304... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.304 Test pressure. The test pressure for each pressure test conducted under...

  1. 49 CFR 195.304 - Test pressure.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Test pressure. 195.304 Section 195.304... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.304 Test pressure. The test pressure for each pressure test conducted under...

  2. 49 CFR 195.304 - Test pressure.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Test pressure. 195.304 Section 195.304... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.304 Test pressure. The test pressure for each pressure test conducted under...

  3. 49 CFR 195.108 - External pressure.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false External pressure. 195.108 Section 195.108... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.108 External pressure. Any external pressure that will be exerted on the...

  4. 49 CFR 195.206 - Material inspection.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Material inspection. 195.206 Section 195.206 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.206 Material inspection. No pipe or other component may be installed in a...

  5. 49 CFR 195.408 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Communications. 195.408 Section 195.408... PIPELINE Operation and Maintenance § 195.408 Communications. (a) Each operator must have a communication... system. (b) The communication system required by paragraph (a) of this section must, as a minimum...

  6. 49 CFR 195.216 - Welding: Miter joints.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Welding: Miter joints. 195.216 Section 195.216 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.216 Welding: Miter joints. A miter joint is not permitted (not including...

  7. 49 CFR 195.216 - Welding: Miter joints.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Welding: Miter joints. 195.216 Section 195.216 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.216 Welding: Miter joints. A miter joint is not permitted (not including...

  8. 49 CFR 195.216 - Welding: Miter joints.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Welding: Miter joints. 195.216 Section 195.216 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.216 Welding: Miter joints. A miter joint is not permitted (not including...

  9. 49 CFR 195.216 - Welding: Miter joints.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Welding: Miter joints. 195.216 Section 195.216 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.216 Welding: Miter joints. A miter joint is not permitted (not including...

  10. 49 CFR 195.210 - Pipeline location.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Pipeline location. 195.210 Section 195.210 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.210 Pipeline location. (a) Pipeline right-of-way must be selected to avoid, as...

  11. Decrease of miR-195 Promotes Chondrocytes Proliferation and Maintenance of Chondrogenic Phenotype via Targeting FGF-18 Pathway

    PubMed Central

    Wang, Yong; Yang, Tao; Liu, Yadong; Zhao, Wei; Zhang, Zhen; Lu, Ming; Zhang, Weiguo

    2017-01-01

    Slow growth and rapid loss of chondrogenic phenotypes are the major problems affecting chronic cartilage lesions. The role of microRNA-195 (miR-195) and its detailed working mechanism in the fore-mentioned process remains unknown. Fibroblastic growth factor 18 (FGF-18) plays a key role in cartilage homeostasis; whether miR-195 could regulate FGF-18 and its downstream signal pathway in chondrocyte proliferation and maintenance of chondrogenic phenotypes still remains unclear. The present research shows elevated miR-195 but depressed FGF-18 expressed in joint fluid specimens of 20 patients with chronic cartilage lesions and in CH1M and CH3M chondrocytes when compared with that in joint fluid specimens without cartilage lesions and in CH1W and CH2W chondrocytes, respectively. The following loss of function test revealed that downregulation of miR-195 by transfection of miR-195 inhibitors promoted chondrocyte proliferation and expression of a type II collagen α I chain (Col2a1)/aggrecan. Through the online informatics analysis we theoretically predicted that miR-195 could bind to a FGF-18 3′ untranslated region (3′UTR), also, we verified that a miR-195 could regulate the FGF-18 and its downstream pathway. The constructed dual luciferase assay further confirmed that FGF-18 was a direct target of miR-195. The executed anti-sense experiment displayed that miR-195 could regulate chondrocyte proliferation and Col2a1/aggrecan expression via the FGF-18 pathway. Finally, through an in vivo anterior cruciate ligament transection (ACLT) model, downregulation of miR-195 presented a significantly protective effect on chronic cartilage lesions. Evaluating all of the outcomes of the current research revealed that a decrease of miR-195 protected chronic cartilage lesions by promoting chondrocyte proliferation and maintenance of chondrogenic phenotypes via the targeting of the FGF-18 pathway and that the miR-195/FGF-18 axis could be a potential target in the treatment of cartilage lesions. PMID:28471382

  12. Decrease of miR-195 Promotes Chondrocytes Proliferation and Maintenance of Chondrogenic Phenotype via Targeting FGF-18 Pathway.

    PubMed

    Wang, Yong; Yang, Tao; Liu, Yadong; Zhao, Wei; Zhang, Zhen; Lu, Ming; Zhang, Weiguo

    2017-05-04

    Slow growth and rapid loss of chondrogenic phenotypes are the major problems affecting chronic cartilage lesions. The role of microRNA-195 (miR-195) and its detailed working mechanism in the fore-mentioned process remains unknown. Fibroblastic growth factor 18 (FGF-18) plays a key role in cartilage homeostasis; whether miR-195 could regulate FGF-18 and its downstream signal pathway in chondrocyte proliferation and maintenance of chondrogenic phenotypes still remains unclear. The present research shows elevated miR-195 but depressed FGF-18 expressed in joint fluid specimens of 20 patients with chronic cartilage lesions and in CH1M and CH3M chondrocytes when compared with that in joint fluid specimens without cartilage lesions and in CH1W and CH2W chondrocytes, respectively. The following loss of function test revealed that downregulation of miR-195 by transfection of miR-195 inhibitors promoted chondrocyte proliferation and expression of a type II collagen α I chain (Col2a1)/aggrecan. Through the online informatics analysis we theoretically predicted that miR-195 could bind to a FGF-18 3' untranslated region (3'UTR), also, we verified that a miR-195 could regulate the FGF-18 and its downstream pathway. The constructed dual luciferase assay further confirmed that FGF-18 was a direct target of miR-195. The executed anti-sense experiment displayed that miR-195 could regulate chondrocyte proliferation and Col2a1/aggrecan expression via the FGF-18 pathway. Finally, through an in vivo anterior cruciate ligament transection (ACLT) model, downregulation of miR-195 presented a significantly protective effect on chronic cartilage lesions. Evaluating all of the outcomes of the current research revealed that a decrease of miR-195 protected chronic cartilage lesions by promoting chondrocyte proliferation and maintenance of chondrogenic phenotypes via the targeting of the FGF-18 pathway and that the miR-195/FGF-18 axis could be a potential target in the treatment of cartilage lesions.

  13. BDNF-mediates Down-regulation of MicroRNA-195 Inhibits Ischemic Cardiac Apoptosis in Rats

    PubMed Central

    Hang, Pengzhou; Sun, Chuan; Guo, Jing; Zhao, Jing; Du, Zhimin

    2016-01-01

    Background: Our previous studies suggested that brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) axis inhibited cardiomyocyte apoptosis in myocardial infarction (MI). However, the relationship between BDNF and microRNA (miRNA) in cardiomyocytes are unclear. The present study was performed to investigate the role of miR-195 and the interplay between BDNF and miR-195 in ischemic cardiomyocyte apoptosis. Methods: Male Wistar rats were subjected to coronary artery ligation, and primary neonatal rat ventricular myocytes were treated with hypoxia or hydrogen peroxide (H2O2). BDNF level in rat ventricles was measured by enzyme linked immunosorbent assay (ELISA). miR-195 mimic, inhibitor or negative control was transfected into the cardiomyocytes. Cell viability and apoptosis were detected by MTT assay and TdT-mediated dUTP nick end labeling (TUNEL) staining, respectively. Cardiac function and apoptosis were detected in MI rats intravenously injected with antagomiR-195. Luciferase assay, Western blot and Real-time RT-PCR were employed to clarify the interplay between miR-195 and BDNF. Results: miR-195 level was dynamically regulated in response to MI and significantly increased in ischemic regions 24 h post-MI as well as in hypoxic or H2O2-treated cardiomyocytes. Meanwhile, BDNF protein level was rapidly increased in MI rats and H2O2-treated cardiomyocytes. Apoptosis in both hypoxic and H2O2-treated cardiomyocytes were markedly reduced and cell viability was increased by miR-195 inhibitor. Moreover, inhibition of miR-195 significantly improved cardiac function of MI rats. Bcl-2 but not BDNF was validated as the direct target of miR-195. Furthermore, BDNF abolished the pro-apoptotic role of miR-195, which was reversed by its scavenger TrkB-Fc. Conclusion: Up-regulation of miR-195 in ischemic cardiomyocytes promotes ischemic apoptosis by targeting Bcl-2. BDNF mitigated the pro-apoptotic effect of miR-195 in rat cardiomyocytes. These findings may provide better understanding of the pro-apoptotic role of miR-195 in MI and suggest that BDNF/miR-195/Bcl-2 axis may be beneficial for limiting myocardial ischemic injury. PMID:27489501

  14. 49 CFR 195.430 - Firefighting equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Firefighting equipment. 195.430 Section 195.430... PIPELINE Operation and Maintenance § 195.430 Firefighting equipment. Each operator shall maintain adequate firefighting equipment at each pump station and breakout tank area. The equipment must be— (a) In proper...

  15. 16 CFR 1.95 - Procedures upon election.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Procedures upon election. 1.95 Section 1.95 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE GENERAL PROCEDURES Penalties for Violation of Appliance Labeling Rules § 1.95 Procedures upon election. (a) After...

  16. 46 CFR 195.09-5 - General.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false General. 195.09-5 Section 195.09-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Scientific Equipment § 195.09-5 General. (a) All scientific equipment shall be...

  17. 46 CFR 195.09-5 - General.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false General. 195.09-5 Section 195.09-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Scientific Equipment § 195.09-5 General. (a) All scientific equipment shall be...

  18. 49 CFR 195.557 - Which pipelines must have coating for external corrosion control?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... corrosion control? 195.557 Section 195.557 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.557 Which pipelines must have coating for external corrosion control? Except bottoms of aboveground breakout tanks, each...

  19. 49 CFR 195.104 - Variations in pressure.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Variations in pressure. 195.104 Section 195.104... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.104 Variations in pressure. If, within a pipeline system, two or more...

  20. 49 CFR 195.104 - Variations in pressure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Variations in pressure. 195.104 Section 195.104... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.104 Variations in pressure. If, within a pipeline system, two or more...

  1. 49 CFR 195.104 - Variations in pressure.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Variations in pressure. 195.104 Section 195.104... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.104 Variations in pressure. If, within a pipeline system, two or more...

  2. 49 CFR 195.104 - Variations in pressure.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Variations in pressure. 195.104 Section 195.104... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.104 Variations in pressure. If, within a pipeline system, two or more...

  3. 49 CFR 195.104 - Variations in pressure.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Variations in pressure. 195.104 Section 195.104... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.104 Variations in pressure. If, within a pipeline system, two or more...

  4. 49 CFR 195.557 - Which pipelines must have coating for external corrosion control?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... corrosion control? 195.557 Section 195.557 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.557 Which pipelines must have coating for external corrosion control? Except bottoms of aboveground breakout tanks, each...

  5. 49 CFR 195.557 - Which pipelines must have coating for external corrosion control?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... corrosion control? 195.557 Section 195.557 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.557 Which pipelines must have coating for external corrosion control? Except bottoms of aboveground breakout tanks, each...

  6. 49 CFR 195.557 - Which pipelines must have coating for external corrosion control?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... corrosion control? 195.557 Section 195.557 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.557 Which pipelines must have coating for external corrosion control? Except bottoms of aboveground breakout tanks, each...

  7. 46 CFR 195.30-5 - General.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false General. 195.30-5 Section 195.30-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Protection From Refrigerants § 195.30-5 General. (a) Each self-contained breathing...

  8. 49 CFR 195.254 - Above ground components.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Above ground components. 195.254 Section 195.254 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.254 Above ground components. (a) Any component may be installed above ground in...

  9. 49 CFR 195.254 - Above ground components.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Above ground components. 195.254 Section 195.254 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.254 Above ground components. (a) Any component may be installed above ground in...

  10. 49 CFR 195.440 - Public awareness.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Public awareness. 195.440 Section 195.440... PIPELINE Operation and Maintenance § 195.440 Public awareness. (a) Each pipeline operator must develop and implement a written continuing public education program that follows the guidance provided in the American...

  11. 49 CFR 195.440 - Public awareness.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Public awareness. 195.440 Section 195.440... PIPELINE Operation and Maintenance § 195.440 Public awareness. (a) Each pipeline operator must develop and implement a written continuing public education program that follows the guidance provided in the American...

  12. 46 CFR 195.07-1 - Application.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Application. 195.07-1 Section 195.07-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Anchors, Chains, and Hawsers § 195.07-1 Application. (a) The provisions of...

  13. 49 CFR 195.557 - Which pipelines must have coating for external corrosion control?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... corrosion control? 195.557 Section 195.557 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.557 Which pipelines must have coating for external corrosion control? Except bottoms of aboveground breakout tanks, each...

  14. Integrated analysis identifies microRNA-195 as a suppressor of Hippo-YAP pathway in colorectal cancer.

    PubMed

    Sun, Min; Song, Haibin; Wang, Shuyi; Zhang, Chunxiao; Zheng, Liang; Chen, Fangfang; Shi, Dongdong; Chen, Yuanyuan; Yang, Chaogang; Xiang, Zhenxian; Liu, Qing; Wei, Chen; Xiong, Bin

    2017-03-29

    With persistent inconsistencies in colorectal cancer (CRC) miRNAs expression data, it is crucial to shift toward inclusion of a "pre-laboratory" integrated analysis to expedite effective precision medicine and translational research. Aberrant expression of hsa-miRNA-195 (miR-195) which is distinguished as a clinically noteworthy miRNA has previously been observed in multiple cancers, yet its role in CRC remains unclear. In this study, we performed an integrated analysis of seven CRC miRNAs expression datasets. The expression of miR-195 was validated in The Cancer Genome Atlas (TCGA) datasets, and an independent validation sample cohort. Colon cancer cells were transfected with miR-195 mimic and inhibitor, after which cell proliferation, colony formation, migration, invasion, and dual luciferase reporter were assayed. Xenograft mouse models were used to determine the role of miR-195 in CRC tumorigenicity in vivo. Four downregulated miRNAs (hsa-let-7a, hsa-miR-125b, hsa-miR-145, and hsa-miR-195) were demonstrated to be potentially useful diagnostic markers in the clinical setting. CRC patients with a decreased level of miR-195-5p in tumor tissues had significantly shortened survival as revealed by the TCGA colon adenocarcinoma (COAD) dataset and our CRC cohort. Overexpression of miR-195-5p in DLD1 and HCT116 cells repressed cell growth, colony formation, invasion, and migration. Inhibition of miR-195-5p function contributed to aberrant cell proliferation, migration, invasion, and epithelial mesenchymal transition (EMT). We identified miR-195-5p binding sites within the 3'-untranslated region (3'-UTR) of the human yes-associated protein (YAP) mRNA. YAP1 expression was downregulated after miR-195-5p treatment by qRT-PCR analysis and western blot. Four downregulated miRNAs were shown to be prime candidates for a panel of biomarkers with sufficient diagnostic accuracy for CRC in a clinical setting. Our integrated microRNA profiling approach identified miR-195-5p independently associated with prognosis in CRC. Our results demonstrated that miR-195-5p was a potent suppressor of YAP1, and miR-195-5p-mediated downregulation of YAP1 significantly reduced tumor development in a mouse CRC xenograft model. In the clinic, miR-195-5p can serve as a prognostic marker to predict the outcome of the CRC patients.

  15. How Ernakulam Became the First Fully Literate District of India = Comment l'Ernakulam devint le premier District entierement alphabete de l'Inde. Notes, Comments...No. 195.

    ERIC Educational Resources Information Center

    Sivadas, S.

    "Lead Kindly Light" was an extensive campaign for the total eradication of illiteracy within 1 year in the Ernakulam District of India. A major sponsor was Kerala Sastra Sahithya Parishad (KSSP), the Science and Education Center of Kerala; responsibility for the project was later handed over to the National Literacy Mission (NLM). The…

  16. 32 CFR 195.10 - Hearings.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Hearings. 195.10 Section 195.10 National Defense... RIGHTS ACT OF 1964 § 195.10 Hearings. (a) Opportunity for hearing. Whenever an opportunity for a hearing... recipient may request of the responsible Department official that the matter be scheduled for hearing or (2...

  17. 32 CFR 195.10 - Hearings.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Hearings. 195.10 Section 195.10 National Defense... RIGHTS ACT OF 1964 § 195.10 Hearings. (a) Opportunity for hearing. Whenever an opportunity for a hearing... recipient may request of the responsible Department official that the matter be scheduled for hearing or (2...

  18. 46 CFR 195.11-30 - Portable tanks.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Portable tanks. 195.11-30 Section 195.11-30 Shipping... AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Portable Vans and Tanks § 195.11-30 Portable tanks. (a) All portable tanks, whether hazardous or nonhazardous commodities, shall be loaded and stowed in accordance...

  19. 46 CFR 195.11-30 - Portable tanks.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Portable tanks. 195.11-30 Section 195.11-30 Shipping... AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Portable Vans and Tanks § 195.11-30 Portable tanks. (a) All portable tanks, whether hazardous or nonhazardous commodities, shall be loaded and stowed in accordance...

  20. 46 CFR 195.11-30 - Portable tanks.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Portable tanks. 195.11-30 Section 195.11-30 Shipping... AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Portable Vans and Tanks § 195.11-30 Portable tanks. (a) All portable tanks, whether hazardous or nonhazardous commodities, shall be loaded and stowed in accordance...

  1. 46 CFR 195.11-30 - Portable tanks.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Portable tanks. 195.11-30 Section 195.11-30 Shipping... AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Portable Vans and Tanks § 195.11-30 Portable tanks. (a) All portable tanks, whether hazardous or nonhazardous commodities, shall be loaded and stowed in accordance...

  2. 46 CFR 195.11-30 - Portable tanks.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Portable tanks. 195.11-30 Section 195.11-30 Shipping... AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Portable Vans and Tanks § 195.11-30 Portable tanks. (a) All portable tanks, whether hazardous or nonhazardous commodities, shall be loaded and stowed in accordance...

  3. 49 CFR 195.436 - Security of facilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Security of facilities. 195.436 Section 195.436... PIPELINE Operation and Maintenance § 195.436 Security of facilities. Each operator shall provide protection for each pumping station and breakout tank area and other exposed facility (such as scraper traps...

  4. 46 CFR 195.11-1 - Application.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Application. 195.11-1 Section 195.11-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Portable Vans and Tanks § 195.11-1 Application. (a) The provisions of this...

  5. 49 CFR 195.234 - Welds: Nondestructive testing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welds: Nondestructive testing. 195.234 Section 195... HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.234 Welds: Nondestructive testing. (a) A weld may be... weld. (b) Any nondestructive testing of welds must be performed— (1) In accordance with a written set...

  6. 27 CFR 41.195 - Trade name certificate.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Trade name certificate. 41.195 Section 41.195 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU..., AND PROCESSED TOBACCO Tobacco Products Importers § 41.195 Trade name certificate. Every person, before...

  7. 27 CFR 41.195 - Trade name certificate.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Trade name certificate. 41.195 Section 41.195 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU..., AND PROCESSED TOBACCO Tobacco Products Importers § 41.195 Trade name certificate. Every person, before...

  8. 27 CFR 41.195 - Trade name certificate.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Trade name certificate. 41.195 Section 41.195 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU..., AND PROCESSED TOBACCO Tobacco Products Importers § 41.195 Trade name certificate. Every person, before...

  9. 27 CFR 41.195 - Trade name certificate.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Trade name certificate. 41.195 Section 41.195 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU..., AND PROCESSED TOBACCO Tobacco Products Importers § 41.195 Trade name certificate. Every person that...

  10. 27 CFR 41.195 - Trade name certificate.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Trade name certificate. 41.195 Section 41.195 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU..., AND PROCESSED TOBACCO Tobacco Products Importers § 41.195 Trade name certificate. Every person, before...

  11. 19 CFR 10.195 - Country of origin criteria.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Country of origin criteria. 10.195 Section 10.195 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. Caribbean Basin Initiative § 10.195...

  12. 49 CFR 195.306 - Test medium.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Test medium. 195.306 Section 195.306... PIPELINE Pressure Testing § 195.306 Test medium. (a) Except as provided in paragraphs (b), (c), and (d) of this section, water must be used as the test medium. (b) Except for offshore pipelines, liquid...

  13. 49 CFR 195.559 - What coating material may I use for external corrosion control?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... corrosion control? 195.559 Section 195.559 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.559 What coating material may I use for external corrosion control? Coating material for external corrosion control under...

  14. 49 CFR 195.559 - What coating material may I use for external corrosion control?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... corrosion control? 195.559 Section 195.559 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.559 What coating material may I use for external corrosion control? Coating material for external corrosion control under...

  15. 49 CFR 195.226 - Welding: Arc burns.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welding: Arc burns. 195.226 Section 195.226 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.226 Welding: Arc burns. (a) Each arc burn must be repaired. (b) An arc burn may...

  16. 49 CFR 195.208 - Welding of supports and braces.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welding of supports and braces. 195.208 Section 195.208 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.208 Welding of supports and braces. Supports or braces may...

  17. 49 CFR 195.214 - Welding procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welding procedures. 195.214 Section 195.214... PIPELINE Construction § 195.214 Welding procedures. (a) Welding must be performed by a qualified welder in accordance with welding procedures qualified under Section 5 of API 1104 or Section IX of the ASME Boiler and...

  18. 12 CFR 195.24 - Service test.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Service test. 195.24 Section 195.24 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY COMMUNITY REINVESTMENT Standards for Assessing Performance § 195.24 Service test. (a) Scope of test. The service test evaluates a savings...

  19. 49 CFR 195.306 - Test medium.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Test medium. 195.306 Section 195.306... PIPELINE Pressure Testing § 195.306 Test medium. (a) Except as provided in paragraphs (b), (c), and (d) of this section, water must be used as the test medium. (b) Except for offshore pipelines, liquid...

  20. 49 CFR 195.304 - Test pressure.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Test pressure. 195.304 Section 195.304... PIPELINE Pressure Testing § 195.304 Test pressure. The test pressure for each pressure test conducted under... case of a pipeline that is not visually inspected for leakage during the test, for at least an...

  1. 12 CFR 195.22 - Lending test.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Lending test. 195.22 Section 195.22 Banks and... Assessing Performance § 195.22 Lending test. (a) Scope of test. (1) The lending test evaluates a savings... lending test except the community development lending criterion. (b) Performance criteria. The appropriate...

  2. 49 CFR 195.406 - Maximum operating pressure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HAZARDOUS LIQUIDS BY PIPELINE Operation and Maintenance § 195.406 Maximum operating pressure. (a) Except for surge pressures and other variations from normal operations, no operator may operate a pipeline at a... 49 Transportation 3 2010-10-01 2010-10-01 false Maximum operating pressure. 195.406 Section 195...

  3. 49 CFR 195.406 - Maximum operating pressure.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... HAZARDOUS LIQUIDS BY PIPELINE Operation and Maintenance § 195.406 Maximum operating pressure. (a) Except for surge pressures and other variations from normal operations, no operator may operate a pipeline at a... 49 Transportation 3 2012-10-01 2012-10-01 false Maximum operating pressure. 195.406 Section 195...

  4. 49 CFR 195.406 - Maximum operating pressure.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... HAZARDOUS LIQUIDS BY PIPELINE Operation and Maintenance § 195.406 Maximum operating pressure. (a) Except for surge pressures and other variations from normal operations, no operator may operate a pipeline at a... 49 Transportation 3 2014-10-01 2014-10-01 false Maximum operating pressure. 195.406 Section 195...

  5. 49 CFR 195.406 - Maximum operating pressure.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... HAZARDOUS LIQUIDS BY PIPELINE Operation and Maintenance § 195.406 Maximum operating pressure. (a) Except for surge pressures and other variations from normal operations, no operator may operate a pipeline at a... 49 Transportation 3 2011-10-01 2011-10-01 false Maximum operating pressure. 195.406 Section 195...

  6. 49 CFR 195.406 - Maximum operating pressure.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... HAZARDOUS LIQUIDS BY PIPELINE Operation and Maintenance § 195.406 Maximum operating pressure. (a) Except for surge pressures and other variations from normal operations, no operator may operate a pipeline at a... 49 Transportation 3 2013-10-01 2013-10-01 false Maximum operating pressure. 195.406 Section 195...

  7. 49 CFR 195.559 - What coating material may I use for external corrosion control?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... corrosion control? 195.559 Section 195.559 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.559 What coating material may I use for external corrosion control? Coating material for external corrosion control under...

  8. 49 CFR 195.559 - What coating material may I use for external corrosion control?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... corrosion control? 195.559 Section 195.559 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.559 What coating material may I use for external corrosion control? Coating material for external corrosion control under...

  9. 49 CFR 195.559 - What coating material may I use for external corrosion control?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... corrosion control? 195.559 Section 195.559 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.559 What coating material may I use for external corrosion control? Coating material for external corrosion control under...

  10. 46 CFR 195.30-90 - Vessels contracted for before November 23, 1992.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Vessels contracted for before November 23, 1992. 195.30-90 Section 195.30-90 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Protection From Refrigerants § 195...

  11. 46 CFR 195.30-90 - Vessels contracted for before November 23, 1992.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Vessels contracted for before November 23, 1992. 195.30-90 Section 195.30-90 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Protection From Refrigerants § 195...

  12. 49 CFR 195.48 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Scope. 195.48 Section 195.48 Transportation Other... Annual, Accident, and Safety-Related Condition Reporting § 195.48 Scope. This Subpart prescribes... report form PHMSA F 7000-1.1 associated with IM or high consequence areas. [76 FR 25588, May 5, 2011] ...

  13. 49 CFR 195.102 - Design temperature.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Design temperature. 195.102 Section 195.102... PIPELINE Design Requirements § 195.102 Design temperature. (a) Material for components of the system must be chosen for the temperature environment in which the components will be used so that the pipeline...

  14. 49 CFR 195.102 - Design temperature.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Design temperature. 195.102 Section 195.102... PIPELINE Design Requirements § 195.102 Design temperature. (a) Material for components of the system must be chosen for the temperature environment in which the components will be used so that the pipeline...

  15. 40 CFR 35.195 - Maximum federal share.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Maximum federal share. 35.195 Section 35.195 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE... 1443(b)) § 35.195 Maximum federal share. The Regional Administrator may provide a maximum of 75 percent...

  16. 49 CFR 195.214 - Welding procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Welding procedures. 195.214 Section 195.214... PIPELINE Construction § 195.214 Welding procedures. (a) Welding must be performed by a qualified welder in accordance with welding procedures qualified under Section 5 of API 1104 or Section IX of the ASME Boiler and...

  17. 49 CFR 195.214 - Welding procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Welding procedures. 195.214 Section 195.214... PIPELINE Construction § 195.214 Welding procedures. (a) Welding must be performed by a qualified welder in accordance with welding procedures qualified under Section 5 of API 1104 or Section IX of the ASME Boiler and...

  18. 49 CFR 195.226 - Welding: Arc burns.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Welding: Arc burns. 195.226 Section 195.226 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.226 Welding: Arc burns. (a) Each arc burn must be repaired. (b) An arc burn may...

  19. 49 CFR 195.208 - Welding of supports and braces.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Welding of supports and braces. 195.208 Section 195.208 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.208 Welding of supports and braces. Supports or braces may...

  20. 49 CFR 195.226 - Welding: Arc burns.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Welding: Arc burns. 195.226 Section 195.226 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.226 Welding: Arc burns. (a) Each arc burn must be repaired. (b) An arc burn may...

  1. 49 CFR 195.214 - Welding procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Welding procedures. 195.214 Section 195.214... PIPELINE Construction § 195.214 Welding procedures. (a) Welding must be performed by a qualified welder in accordance with welding procedures qualified under Section 5 of API 1104 or Section IX of the ASME Boiler and...

  2. 49 CFR 195.226 - Welding: Arc burns.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Welding: Arc burns. 195.226 Section 195.226 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.226 Welding: Arc burns. (a) Each arc burn must be repaired. (b) An arc burn may...

  3. 49 CFR 195.208 - Welding of supports and braces.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Welding of supports and braces. 195.208 Section 195.208 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.208 Welding of supports and braces. Supports or braces may...

  4. 49 CFR 195.214 - Welding procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Welding procedures. 195.214 Section 195.214... PIPELINE Construction § 195.214 Welding procedures. (a) Welding must be performed by a qualified welder in accordance with welding procedures qualified under Section 5 of API 1104 or Section IX of the ASME Boiler and...

  5. 49 CFR 195.208 - Welding of supports and braces.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Welding of supports and braces. 195.208 Section 195.208 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.208 Welding of supports and braces. Supports or braces may...

  6. 49 CFR 195.208 - Welding of supports and braces.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Welding of supports and braces. 195.208 Section 195.208 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.208 Welding of supports and braces. Supports or braces may...

  7. 49 CFR 195.226 - Welding: Arc burns.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Welding: Arc burns. 195.226 Section 195.226 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.226 Welding: Arc burns. (a) Each arc burn must be repaired. (b) An arc burn may...

  8. 49 CFR 195.58 - Address for written reports.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Address for written reports. 195.58 Section 195.58... PIPELINE Annual, Accident, and Safety-Related Condition Reporting § 195.58 Address for written reports. Each written report required by this subpart must be made to the Office of Pipeline Safety, Pipeline...

  9. 21 CFR 137.195 - Crushed wheat.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Crushed wheat. 137.195 Section 137.195 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... Related Products § 137.195 Crushed wheat. Crushed wheat, coarse ground wheat, is the food prepared by so...

  10. 32 CFR 195.13 - Effect on other issuances.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Effect on other issuances. 195.13 Section 195.13 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED... TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 § 195.13 Effect on other issuances. All issuances heretofore...

  11. 41 CFR 102-34.195 - Must we submit a report concerning motor vehicles exempted under this subpart?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... REGULATION PERSONAL PROPERTY 34-MOTOR VEHICLE MANAGEMENT Identifying and Registering Motor Vehicles Identification Exemptions § 102-34.195 Must we submit a report concerning motor vehicles exempted under this... concerning motor vehicles exempted under this subpart? 102-34.195 Section 102-34.195 Public Contracts and...

  12. 41 CFR 102-34.195 - Must we submit a report concerning motor vehicles exempted under this subpart?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... REGULATION PERSONAL PROPERTY 34-MOTOR VEHICLE MANAGEMENT Identifying and Registering Motor Vehicles Identification Exemptions § 102-34.195 Must we submit a report concerning motor vehicles exempted under this... concerning motor vehicles exempted under this subpart? 102-34.195 Section 102-34.195 Public Contracts and...

  13. 41 CFR 102-34.195 - Must we submit a report concerning motor vehicles exempted under this subpart?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... REGULATION PERSONAL PROPERTY 34-MOTOR VEHICLE MANAGEMENT Identifying and Registering Motor Vehicles Identification Exemptions § 102-34.195 Must we submit a report concerning motor vehicles exempted under this... concerning motor vehicles exempted under this subpart? 102-34.195 Section 102-34.195 Public Contracts and...

  14. 41 CFR 102-34.195 - Must we submit a report concerning motor vehicles exempted under this subpart?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... REGULATION PERSONAL PROPERTY 34-MOTOR VEHICLE MANAGEMENT Identifying and Registering Motor Vehicles Identification Exemptions § 102-34.195 Must we submit a report concerning motor vehicles exempted under this... concerning motor vehicles exempted under this subpart? 102-34.195 Section 102-34.195 Public Contracts and...

  15. 41 CFR 102-34.195 - Must we submit a report concerning motor vehicles exempted under this subpart?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... REGULATION PERSONAL PROPERTY 34-MOTOR VEHICLE MANAGEMENT Identifying and Registering Motor Vehicles Identification Exemptions § 102-34.195 Must we submit a report concerning motor vehicles exempted under this... concerning motor vehicles exempted under this subpart? 102-34.195 Section 102-34.195 Public Contracts and...

  16. 49 CFR 195.561 - When must I inspect pipe coating used for external corrosion control?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... corrosion control? 195.561 Section 195.561 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.561 When must I inspect pipe coating used for external corrosion control? (a) You must inspect all external pipe coating...

  17. 49 CFR 195.561 - When must I inspect pipe coating used for external corrosion control?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... corrosion control? 195.561 Section 195.561 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.561 When must I inspect pipe coating used for external corrosion control? (a) You must inspect all external pipe coating...

  18. 49 CFR 195.5 - Conversion to service subject to this part.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Conversion to service subject to this part. 195.5 Section 195.5 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE General § 195.5 Conversion to service subject to this part. (a) A...

  19. 12 CFR 195.23 - Investment test.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Investment test. 195.23 Section 195.23 Banks... for Assessing Performance § 195.23 Investment test. (a) Scope of test. The investment test evaluates a... lending or service tests may not be considered under the investment test. (c) Affiliate investment. At a...

  20. 49 CFR 195.561 - When must I inspect pipe coating used for external corrosion control?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... corrosion control? 195.561 Section 195.561 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.561 When must I inspect pipe coating used for external corrosion control? (a) You must inspect all external pipe coating...

  1. 49 CFR 195.561 - When must I inspect pipe coating used for external corrosion control?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... corrosion control? 195.561 Section 195.561 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.561 When must I inspect pipe coating used for external corrosion control? (a) You must inspect all external pipe coating...

  2. 49 CFR 195.561 - When must I inspect pipe coating used for external corrosion control?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... corrosion control? 195.561 Section 195.561 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.561 When must I inspect pipe coating used for external corrosion control? (a) You must inspect all external pipe coating...

  3. 49 CFR 195.106 - Internal design pressure.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Internal design pressure. 195.106 Section 195.106... PIPELINE Design Requirements § 195.106 Internal design pressure. (a) Internal design pressure for the pipe in a pipeline is determined in accordance with the following formula: P=(2St/D)×E×F P=Internal design...

  4. 49 CFR 195.438 - Smoking or open flames.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Smoking or open flames. 195.438 Section 195.438... PIPELINE Operation and Maintenance § 195.438 Smoking or open flames. Each operator shall prohibit smoking and open flames in each pump station area and each breakout tank area where there is a possibility of...

  5. 49 CFR 195.438 - Smoking or open flames.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Smoking or open flames. 195.438 Section 195.438... PIPELINE Operation and Maintenance § 195.438 Smoking or open flames. Each operator shall prohibit smoking and open flames in each pump station area and each breakout tank area where there is a possibility of...

  6. 49 CFR 195.438 - Smoking or open flames.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Smoking or open flames. 195.438 Section 195.438... PIPELINE Operation and Maintenance § 195.438 Smoking or open flames. Each operator shall prohibit smoking and open flames in each pump station area and each breakout tank area where there is a possibility of...

  7. 49 CFR 195.438 - Smoking or open flames.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Smoking or open flames. 195.438 Section 195.438... PIPELINE Operation and Maintenance § 195.438 Smoking or open flames. Each operator shall prohibit smoking and open flames in each pump station area and each breakout tank area where there is a possibility of...

  8. 49 CFR 195.438 - Smoking or open flames.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Smoking or open flames. 195.438 Section 195.438... PIPELINE Operation and Maintenance § 195.438 Smoking or open flames. Each operator shall prohibit smoking and open flames in each pump station area and each breakout tank area where there is a possibility of...

  9. 42 CFR 416.195 - Determination of membership in new classes of new technology IOLs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... technology IOLs. 416.195 Section 416.195 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT... Adjustment in Payment Amounts for New Technology Intraocular Lenses Furnished by Ambulatory Service Centers § 416.195 Determination of membership in new classes of new technology IOLs. (a) Factors to be...

  10. 42 CFR 416.195 - Determination of membership in new classes of new technology IOLs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... technology IOLs. 416.195 Section 416.195 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT... Adjustment in Payment Amounts for New Technology Intraocular Lenses Furnished by Ambulatory Service Centers § 416.195 Determination of membership in new classes of new technology IOLs. (a) Factors to be...

  11. 49 CFR 195.571 - What criteria must I use to determine the adequacy of cathodic protection?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... of cathodic protection? 195.571 Section 195.571 Transportation Other Regulations Relating to... (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.571 What criteria must I use to determine the adequacy of cathodic protection? Cathodic protection required by this...

  12. 49 CFR 195.571 - What criteria must I use to determine the adequacy of cathodic protection?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of cathodic protection? 195.571 Section 195.571 Transportation Other Regulations Relating to... (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.571 What criteria must I use to determine the adequacy of cathodic protection? Cathodic protection required by this...

  13. 49 CFR 195.106 - Internal design pressure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Internal design pressure. 195.106 Section 195.106... PIPELINE Design Requirements § 195.106 Internal design pressure. (a) Internal design pressure for the pipe in a pipeline is determined in accordance with the following formula: P=(2St/D)×E×F P=Internal design...

  14. 49 CFR 195.310 - Records.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Records. 195.310 Section 195.310 Transportation... PIPELINE Pressure Testing § 195.310 Records. (a) A record must be made of each pressure test required by this subpart, and the record of the latest test must be retained as long as the facility tested is in...

  15. 49 CFR 195.310 - Records.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Records. 195.310 Section 195.310 Transportation... PIPELINE Pressure Testing § 195.310 Records. (a) A record must be made of each pressure test required by this subpart, and the record of the latest test must be retained as long as the facility tested is in...

  16. 49 CFR 195.310 - Records.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Records. 195.310 Section 195.310 Transportation... PIPELINE Pressure Testing § 195.310 Records. (a) A record must be made of each pressure test required by this subpart, and the record of the latest test must be retained as long as the facility tested is in...

  17. 46 CFR 195.40-1 - Pilot boarding equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Pilot boarding equipment. 195.40-1 Section 195.40-1... CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Pilot Boarding Equipment § 195.40-1 Pilot boarding equipment. (a) This section applies to each vessel that normally embarks or disembarks a pilot from a pilot...

  18. 46 CFR 195.40-1 - Pilot boarding equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Pilot boarding equipment. 195.40-1 Section 195.40-1... CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Pilot Boarding Equipment § 195.40-1 Pilot boarding equipment. (a) This section applies to each vessel that normally embarks or disembarks a pilot from a pilot...

  19. 40 CFR 46.195 - Project period.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Project period. 46.195 Section 46.195... During the Fellowship § 46.195 Project period. Based on the “Date Fellow Will Enter on Duty” which you enter on the Activation Notice (see § 46.185(a)), EPA will establish the project period for the...

  20. 42 CFR 416.195 - Determination of membership in new classes of new technology IOLs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... technology IOLs. 416.195 Section 416.195 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT... Payment Amounts for New Technology Intraocular Lenses Furnished by Ambulatory Service Centers § 416.195 Determination of membership in new classes of new technology IOLs. (a) Factors to be considered. CMS uses the...

  1. 49 CFR 195.212 - Bending of pipe.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Bending of pipe. 195.212 Section 195.212... PIPELINE Construction § 195.212 Bending of pipe. (a) Pipe must not have a wrinkle bend. (b) Each field bend must comply with the following: (1) A bend must not impair the serviceability of the pipe. (2) Each...

  2. 49 CFR 195.212 - Bending of pipe.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Bending of pipe. 195.212 Section 195.212... PIPELINE Construction § 195.212 Bending of pipe. (a) Pipe must not have a wrinkle bend. (b) Each field bend must comply with the following: (1) A bend must not impair the serviceability of the pipe. (2) Each...

  3. 40 CFR 46.195 - Project period.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Project period. 46.195 Section 46.195... During the Fellowship § 46.195 Project period. Based on the “Date Fellow Will Enter on Duty” which you enter on the Activation Notice (see § 46.185(a)), EPA will establish the project period for the...

  4. 40 CFR 46.195 - Project period.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Project period. 46.195 Section 46.195... During the Fellowship § 46.195 Project period. Based on the “Date Fellow Will Enter on Duty” which you enter on the Activation Notice (see § 46.185(a)), EPA will establish the project period for the...

  5. 40 CFR 46.195 - Project period.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Project period. 46.195 Section 46.195... During the Fellowship § 46.195 Project period. Based on the “Date Fellow Will Enter on Duty” which you enter on the Activation Notice (see § 46.185(a)), EPA will establish the project period for the...

  6. 40 CFR 46.195 - Project period.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Project period. 46.195 Section 46.195... During the Fellowship § 46.195 Project period. Based on the “Date Fellow Will Enter on Duty” which you enter on the Activation Notice (see § 46.185(a)), EPA will establish the project period for the...

  7. Safety of minimally invasive mitral valve surgery without aortic cross-clamp.

    PubMed

    Umakanthan, Ramanan; Leacche, Marzia; Petracek, Michael R; Kumar, Sathappan; Solenkova, Nataliya V; Kaiser, Clayton A; Greelish, James P; Balaguer, Jorge M; Ahmad, Rashid M; Ball, Stephen K; Hoff, Steven J; Absi, Tarek S; Kim, Betty S; Byrne, John G

    2008-05-01

    We developed a technique for open heart surgery through a small (5 cm) right-anterolateral thoracotomy without aortic cross-clamp. One hundred and ninety-five consecutive patients (103 male and 92 female), age 69 +/- 8 years, underwent surgery between January 2006 and July 2007. Mean preoperative New York Heart Association function class was 2.2 +/- 0.7. Thirty-five patients (18%) had an ejection fraction 0.35 or less. Cardiopulmonary bypass was instituted through femoral (176 of 195, 90%), axillary (18 of 195, 9%), or direct aortic (1 of 195, 0.5%) cannulation. Under cold fibrillatory arrest (mean temperature 28.2 degrees C) without aortic cross-clamp, mitral valve repair (72 of 195, 37%), mitral valve replacement (117 of 195, 60%), or other (6 of 195, 3%) procedures were performed. Concomitant procedures included maze (45 of 195, 23%), patent foramen ovale closure (42 of 195, 22%) and tricuspid valve repair (16 of 195, 8%), or replacement (4 of 195, 2%). Thirty-day mortality was 3% (6 of 195). Duration of fibrillatory arrest, cardiopulmonary bypass, and "skin to skin" surgery were 88 +/- 32, 118 +/- 52, and 280 +/- 78 minutes, respectively. Ten patients (5%) underwent reexploration for bleeding and 44% did not receive any blood transfusions. Six patients (3%) sustained a postoperative stroke, eight (4%) developed low cardiac output syndrome, and two (1%) developed renal failure requiring hemodialysis. Mean length of hospital stay was 7 +/- 4.8 days. This simplified technique of minimally invasive open heart surgery is safe and easily reproducible. Fibrillatory arrest without aortic cross-clamping, with coronary perfusion against an intact aortic valve, does not increase the risk of stroke or low cardiac output. It may be particularly useful in higher risk patients in whom sternotomy with aortic clamping is less desirable.

  8. CXC195 suppresses proliferation and inflammatory response in LPS-induced human hepatocellular carcinoma cells via regulating TLR4-MyD88-TAK1-mediated NF-κB and MAPK pathway

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Yiting; Tu, Qunfei; Yan, Wei

    Highlights: • CXC195 exhibited significant anti-proliferative effect and induced cell cycle arrest in LPS-induced HepG2 cells. • CXC195 suppressed the release of pro-inflammatory mediators in LPS-induced HepG2 cells. • CXC195 regulated TLR4-MyD88-TAK1-mediated NF-κB and MAPK pathway in LPS-induced HepG2 cells. - Abstract: CXC195 showed strong protective effects in neuronal apoptosis by exerting its antioxidant activity. However, the anti-cancer effects of CXC195 is still with limited acquaintance. Here, we investigated the role of CXC195 in lipopolysaccharide (LPS)-induced human hepatocellular carcinoma (HCC) cells lines (HepG2) and the possible signaling pathways. CXC195 exhibited significant anti-proliferative effect and induced cell cycle arrest in LPS-inducedmore » HepG2 cells. In addition, CXC195 suppressed the release of pro-inflammatory mediators in LPS-induced HepG2 cells, including TNF-α, iNOS, IL-1β, IL-6, CC chemokine ligand (CCL)-2, CCL-22 and epidermal growth factor receptor (EGFR). Moreover, CXC195 inhibited the expressions and interactions of TLR4, MyD88 and TAK1, NF-κB translocation to nucleus and its DNA binding activity, phosphorylation of ERK1/2, p38 and JNK. Our results suggested that treatment with CXC195 could attenuate the TLR4-mediated proliferation and inflammatory response in LPS-induced HepG2 cells, thus might be beneficial for the treatment of HCC.« less

  9. MicroRNA-195 targets ADP-ribosylation factor-like protein 2 to induce apoptosis in human embryonic stem cell-derived neural progenitor cells

    PubMed Central

    Zhou, Y; Jiang, H; Gu, J; Tang, Y; Shen, N; Jin, Y

    2013-01-01

    Neural progenitor cells (NPCs) derived from human embryonic stem cells (hESCs) have great potential in cell therapy, drug screening and toxicity testing of neural degenerative diseases. However, the molecular regulation of their proliferation and apoptosis, which needs to be revealed before clinical application, is largely unknown. MicroRNA miR-195 is known to be expressed in the brain and is involved in a variety of proapoptosis or antiapoptosis processes in cancer cells. Here, we defined the proapoptotic role of miR-195 in NPCs derived from two independent hESC lines (human embryonic stem cell-derived neural progenitor cells, hESC-NPCs). Overexpression of miR-195 in hESC-NPCs induced extensive apoptotic cell death. Consistently, global transcriptional microarray analyses indicated that miR-195 primarily regulated genes associated with apoptosis in hESC-NPCs. Mechanistically, a small GTP-binding protein ADP-ribosylation factor-like protein 2 (ARL2) was identified as a direct target of miR-195. Silencing ARL2 in hESC-NPCs provoked an apoptotic phenotype resembling that of miR-195 overexpression, revealing for the first time an essential role of ARL2 for the survival of human NPCs. Moreover, forced expression of ALR2 could abolish the cell number reduction caused by miR-195 overexpression. Interestingly, we found that paraquat, a neurotoxin, not only induced apoptosis but also increased miR-195 and reduced ARL2 expression in hESC-NPCs, indicating the possible involvement of miR-195 and ARL2 in neurotoxin-induced NPC apoptosis. Notably, inhibition of miR-195 family members could block neurotoxin-induced NPC apoptosis. Collectively, miR-195 regulates cell apoptosis in a context-dependent manner through directly targeting ARL2. The finding of the critical role of ARL2 for the survival of human NPCs and association of miR-195 and ARL2 with neurotoxin-induced apoptosis have important implications for understanding molecular mechanisms that control NPC survival and would facilitate our manipulation of the neurological pathogenesis. PMID:23807224

  10. 28 CFR 19.5 - Report to the Office of Juvenile Justice and Delinquency Prevention.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Report to the Office of Juvenile Justice and Delinquency Prevention. 19.5 Section 19.5 Judicial Administration DEPARTMENT OF JUSTICE USE OF PENALTY MAIL IN THE LOCATION AND RECOVERY OF MISSING CHILDREN § 19.5 Report to the Office of Juvenile...

  11. 49 CFR 195.575 - Which facilities must I electrically isolate and what inspections, tests, and safeguards are...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Which facilities must I electrically isolate and what inspections, tests, and safeguards are required? 195.575 Section 195.575 Transportation Other... Corrosion Control § 195.575 Which facilities must I electrically isolate and what inspections, tests, and...

  12. 12 CFR Appendix B to Part 195 - CRA Notice

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false CRA Notice B Appendix B to Part 195 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY COMMUNITY REINVESTMENT Pt. 195, App. B Appendix B to Part 195—CRA Notice (a) Notice for main offices and, if an interstate savings association...

  13. 30 CFR 250.195 - What notification does MMS require on the production status of wells?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the well in a production status. You must confirm oral notification by telefax or e-mail within those... production status of wells? 250.195 Section 250.195 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT... Information and Reporting Requirements § 250.195 What notification does MMS require on the production status...

  14. 28 CFR 19.5 - Report to the Office of Juvenile Justice and Delinquency Prevention.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Report to the Office of Juvenile Justice and Delinquency Prevention. 19.5 Section 19.5 Judicial Administration DEPARTMENT OF JUSTICE USE OF PENALTY MAIL IN THE LOCATION AND RECOVERY OF MISSING CHILDREN § 19.5 Report to the Office of Juvenile...

  15. 28 CFR 19.5 - Report to the Office of Juvenile Justice and Delinquency Prevention.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Report to the Office of Juvenile Justice and Delinquency Prevention. 19.5 Section 19.5 Judicial Administration DEPARTMENT OF JUSTICE USE OF PENALTY MAIL IN THE LOCATION AND RECOVERY OF MISSING CHILDREN § 19.5 Report to the Office of Juvenile...

  16. 28 CFR 19.5 - Report to the Office of Juvenile Justice and Delinquency Prevention.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Report to the Office of Juvenile Justice and Delinquency Prevention. 19.5 Section 19.5 Judicial Administration DEPARTMENT OF JUSTICE USE OF PENALTY MAIL IN THE LOCATION AND RECOVERY OF MISSING CHILDREN § 19.5 Report to the Office of Juvenile...

  17. 49 CFR 195.303 - Risk-based alternative to pressure testing older hazardous liquid and carbon dioxide pipelines.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Pressure Testing § 195.303 Risk-based alternative to pressure testing older hazardous liquid and carbon... 49 Transportation 3 2014-10-01 2014-10-01 false Risk-based alternative to pressure testing older hazardous liquid and carbon dioxide pipelines. 195.303 Section 195.303 Transportation Other Regulations...

  18. 49 CFR 195.303 - Risk-based alternative to pressure testing older hazardous liquid and carbon dioxide pipelines.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Pressure Testing § 195.303 Risk-based alternative to pressure testing older hazardous liquid and carbon... 49 Transportation 3 2013-10-01 2013-10-01 false Risk-based alternative to pressure testing older hazardous liquid and carbon dioxide pipelines. 195.303 Section 195.303 Transportation Other Regulations...

  19. 49 CFR 195.303 - Risk-based alternative to pressure testing older hazardous liquid and carbon dioxide pipelines.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Pressure Testing § 195.303 Risk-based alternative to pressure testing older hazardous liquid and carbon... 49 Transportation 3 2012-10-01 2012-10-01 false Risk-based alternative to pressure testing older hazardous liquid and carbon dioxide pipelines. 195.303 Section 195.303 Transportation Other Regulations...

  20. 49 CFR 195.587 - What methods are available to determine the strength of corroded pipe?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... strength of corroded pipe? 195.587 Section 195.587 Transportation Other Regulations Relating to... methods are available to determine the strength of corroded pipe? Under § 195.585, you may use the procedure in ASME B31G, “Manual for Determining the Remaining Strength of Corroded Pipelines,” or the...

  1. 49 CFR 195.587 - What methods are available to determine the strength of corroded pipe?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... strength of corroded pipe? 195.587 Section 195.587 Transportation Other Regulations Relating to... methods are available to determine the strength of corroded pipe? Under § 195.585, you may use the procedure in ASME B31G, “Manual for Determining the Remaining Strength of Corroded Pipelines,” or the...

  2. 40 CFR 195.30 - Failure to remit fee.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Failure to remit fee. 195.30 Section... PROGRAMS RADON PROFICIENCY PROGRAMS Fees § 195.30 Failure to remit fee. EPA will not process an application... appropriate remittance provided in § 195.20(a) has been received by EPA. Failure by a currently EPA-listed...

  3. 40 CFR 195.30 - Failure to remit fee.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Failure to remit fee. 195.30 Section... PROGRAMS RADON PROFICIENCY PROGRAMS Fees § 195.30 Failure to remit fee. EPA will not process an application... appropriate remittance provided in § 195.20(a) has been received by EPA. Failure by a currently EPA-listed...

  4. 40 CFR 195.30 - Failure to remit fee.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Failure to remit fee. 195.30 Section... PROGRAMS RADON PROFICIENCY PROGRAMS Fees § 195.30 Failure to remit fee. EPA will not process an application... appropriate remittance provided in § 195.20(a) has been received by EPA. Failure by a currently EPA-listed...

  5. 41 CFR 102-117.195 - Are there time limits affecting filing of a claim?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Are there time limits affecting filing of a claim? 102-117.195 Section 102-117.195 Public Contracts and Property Management... 117-TRANSPORTATION MANAGEMENT Shipping Freight § 102-117.195 Are there time limits affecting filing of...

  6. 40 CFR 468.14 - Pretreatment standards for existing sources (PSES).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... per 1,000,000 off-pounds of copper or copper alloy hot rolled Chromium 0.045 0.018 Copper 0.195 0.103... rolled English units—pounds per 1,000,000 off-pounds of copper or copper alloy cold rolled Chromium 0.166... drawn Chromium 0.037 0.015 Copper 0.161 0.085 Lead 0.012 0.011 Nickel 0.163 0.107 Zinc 0.124 0.051 TTO 0...

  7. 41 CFR 102-33.195 - Do we need an automated system to account for aircraft costs?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... system to account for aircraft costs? 102-33.195 Section 102-33.195 Public Contracts and Property... for the Cost of Government Aircraft § 102-33.195 Do we need an automated system to account for... automated system to account for aircraft costs by collecting the cost data elements required by the Federal...

  8. 49 CFR 195.305 - Testing of components.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.305 Testing of components. (a) Each pressure test under § 195.302 must test...

  9. 49 CFR 195.305 - Testing of components.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.305 Testing of components. (a) Each pressure test under § 195.302 must test...

  10. 49 CFR 195.305 - Testing of components.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.305 Testing of components. (a) Each pressure test under § 195.302 must test...

  11. 49 CFR 195.305 - Testing of components.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.305 Testing of components. (a) Each pressure test under § 195.302 must test...

  12. 49 CFR 195.305 - Testing of components.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.305 Testing of components. (a) Each pressure test under § 195.302 must test...

  13. 49 CFR 195.413 - Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the Gulf of Mexico and its inlets. 195.413 Section 195.413 Transportation Other Regulations Relating... Maintenance § 195.413 Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets. (a... shall prepare and follow a procedure to identify its pipelines in the Gulf of Mexico and its inlets in...

  14. 41 CFR 102-36.195 - What type of excess personal property may we furnish to our project grantees?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What type of excess personal property may we furnish to our project grantees? 102-36.195 Section 102-36.195 Public Contracts... for Non-Federal Recipients Project Grantees § 102-36.195 What type of excess personal property may we...

  15. 41 CFR 102-36.195 - What type of excess personal property may we furnish to our project grantees?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false What type of excess personal property may we furnish to our project grantees? 102-36.195 Section 102-36.195 Public Contracts... for Non-Federal Recipients Project Grantees § 102-36.195 What type of excess personal property may we...

  16. 41 CFR 102-36.195 - What type of excess personal property may we furnish to our project grantees?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What type of excess personal property may we furnish to our project grantees? 102-36.195 Section 102-36.195 Public Contracts... for Non-Federal Recipients Project Grantees § 102-36.195 What type of excess personal property may we...

  17. 41 CFR 102-36.195 - What type of excess personal property may we furnish to our project grantees?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false What type of excess personal property may we furnish to our project grantees? 102-36.195 Section 102-36.195 Public Contracts... for Non-Federal Recipients Project Grantees § 102-36.195 What type of excess personal property may we...

  18. 41 CFR 102-73.195 - What types of special purpose space may the Department of Health and Human Services lease?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... purpose space may the Department of Health and Human Services lease? 102-73.195 Section 102-73.195 Public... Delegations § 102-73.195 What types of special purpose space may the Department of Health and Human Services lease? The Department of Health and Human Services is delegated authority to lease laboratories (lease...

  19. 49 CFR 195.413 - Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... the Gulf of Mexico and its inlets. 195.413 Section 195.413 Transportation Other Regulations Relating... Maintenance § 195.413 Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets. (a... shall prepare and follow a procedure to identify its pipelines in the Gulf of Mexico and its inlets in...

  20. 49 CFR 195.413 - Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... the Gulf of Mexico and its inlets. 195.413 Section 195.413 Transportation Other Regulations Relating... Maintenance § 195.413 Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets. (a... shall prepare and follow a procedure to identify its pipelines in the Gulf of Mexico and its inlets in...

  1. 49 CFR 195.413 - Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the Gulf of Mexico and its inlets. 195.413 Section 195.413 Transportation Other Regulations Relating... Maintenance § 195.413 Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets. (a... shall prepare and follow a procedure to identify its pipelines in the Gulf of Mexico and its inlets in...

  2. 49 CFR 195.413 - Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the Gulf of Mexico and its inlets. 195.413 Section 195.413 Transportation Other Regulations Relating... Maintenance § 195.413 Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets. (a... shall prepare and follow a procedure to identify its pipelines in the Gulf of Mexico and its inlets in...

  3. Sustainable syntrophic growth of Dehalococcoides ethenogenes strain 195 with Desulfovibrio vulgaris Hildenborough and Methanobacterium congolense: global transcriptomic and proteomic analyses

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Men, Yujie; Feil, Helene; Verberkmoes, Nathan C

    2012-01-01

    Dehalococcoides ethenogenes strain 195 (DE195) was grown in a sustainable syntrophic association with Desulfovibrio vulgaris Hildenborough (DVH) as a co-culture, as well as with DVH and the hydrogenotrophic methanogen Methanobacterium congolense (MC) as a tri-culture using lactate as the sole energy and carbon source. In the co- and tri-cultures, maximum dechlorination rates of DE195 were enhanced by approximately three times (11.0 0.01 lmol per day for the co-culture and 10.1 0.3 lmol per day for the tri-culture) compared with DE195 grown alone (3.8 0.1 lmol per day). Cell yield of DE195 was enhanced in the co-culture (9.0 0.5107 cells permore » lmol Cl released, compared with 6.8 0.9107 cells per lmol Cl released for the pure culture), whereas no further enhancement was observed in the tri-culture (7.3 1.8107 cells per lmol Cl released). The transcriptome of DE195 grown in the co-culture was analyzed using a wholegenome microarray targeting DE195, which detected 102 significantly up- or down-regulated genes compared with DE195 grown in isolation, whereas no significant transcriptomic difference was observed between co- and tri-cultures. Proteomic analysis showed that 120 proteins were differentially expressed in the co-culture compared with DE195 grown in isolation. Physiological, transcriptomic and proteomic results indicate that the robust growth of DE195 in co- and tri-cultures is because of the advantages associated with the capabilities of DVH to ferment lactate to provide H2 and acetate for growth, along with potential benefits from proton translocation, cobalamin-salvaging and amino acid biosynthesis, whereas MC in the tri-culture provided no significant additional benefits beyond those of DVH.« less

  4. 41 CFR 102-37.195 - Does a SASP have to have a donee in mind to request surplus property?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Does a SASP have to have a donee in mind to request surplus property? 102-37.195 Section 102-37.195 Public Contracts and...) Screening and Requesting Property § 102-37.195 Does a SASP have to have a donee in mind to request surplus...

  5. 41 CFR 102-37.195 - Does a SASP have to have a donee in mind to request surplus property?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Does a SASP have to have a donee in mind to request surplus property? 102-37.195 Section 102-37.195 Public Contracts and...) Screening and Requesting Property § 102-37.195 Does a SASP have to have a donee in mind to request surplus...

  6. 41 CFR 102-37.195 - Does a SASP have to have a donee in mind to request surplus property?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Does a SASP have to have a donee in mind to request surplus property? 102-37.195 Section 102-37.195 Public Contracts and...) Screening and Requesting Property § 102-37.195 Does a SASP have to have a donee in mind to request surplus...

  7. 41 CFR 102-37.195 - Does a SASP have to have a donee in mind to request surplus property?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Does a SASP have to have a donee in mind to request surplus property? 102-37.195 Section 102-37.195 Public Contracts and...) Screening and Requesting Property § 102-37.195 Does a SASP have to have a donee in mind to request surplus...

  8. 41 CFR 102-37.195 - Does a SASP have to have a donee in mind to request surplus property?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Does a SASP have to have a donee in mind to request surplus property? 102-37.195 Section 102-37.195 Public Contracts and...) Screening and Requesting Property § 102-37.195 Does a SASP have to have a donee in mind to request surplus...

  9. MicroRNA-195 prevents dendritic degeneration and neuron death in rats following chronic brain hypoperfusion

    PubMed Central

    Chen, Xin; Jiang, Xue-Mei; Zhao, Lin-Jing; Sun, Lin-Lin; Yan, Mei-Ling; Tian, You; Zhang, Shuai; Duan, Ming-Jing; Zhao, Hong-Mei; Li, Wen-Rui; Hao, Yang-Yang; Wang, Li-Bo; Xiong, Qiao-Jie; Ai, Jing

    2017-01-01

    Impaired synaptic plasticity and neuron loss are hallmarks of Alzheimer’s disease and vascular dementia. Here, we found that chronic brain hypoperfusion (CBH) by bilateral common carotid artery occlusion (2VO) decreased the total length, numbers and crossings of dendrites and caused neuron death in rat hippocampi and cortices. It also led to increase in N-terminal β-amyloid precursor protein (N-APP) and death receptor-6 (DR6) protein levels and in the activation of caspase-3 and caspase-6. Further study showed that DR6 protein was downregulated by miR-195 overexpression, upregulated by miR-195 inhibition, and unchanged by binding-site mutation and miR-masks. Knockdown of endogenous miR-195 by lentiviral vector-mediated overexpression of its antisense molecule (lenti-pre-AMO-miR-195) decreased the total length, numbers and crossings of dendrites and neuron death, upregulated N-APP and DR6 levels, and elevated cleaved caspase-3 and caspase-6 levels. Overexpression of miR-195 using lenti-pre-miR-195 prevented these changes triggered by 2VO. We conclude that miR-195 is involved in CBH-induced dendritic degeneration and neuron death through activation of the N-APP/DR6/caspase pathway. PMID:28569780

  10. 49 CFR 195.555 - What are the qualifications for supervisors?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.555 What are the... that portion of the corrosion control procedures established under § 195.402(c)(3) for which they are...

  11. 49 CFR 195.555 - What are the qualifications for supervisors?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.555 What are the... that portion of the corrosion control procedures established under § 195.402(c)(3) for which they are...

  12. 49 CFR 195.555 - What are the qualifications for supervisors?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.555 What are the... that portion of the corrosion control procedures established under § 195.402(c)(3) for which they are...

  13. 49 CFR 195.555 - What are the qualifications for supervisors?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.555 What are the... that portion of the corrosion control procedures established under § 195.402(c)(3) for which they are...

  14. 49 CFR 195.555 - What are the qualifications for supervisors?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.555 What are the... that portion of the corrosion control procedures established under § 195.402(c)(3) for which they are...

  15. [Molecular epidemiology of beta-lactamases in ceftazidime-resistant Pseudomonas aeruginosa isolates].

    PubMed

    Er, Halil; Altındiş, Mustafa; Aşık, Gülşah; Demir, Cengiz

    2015-04-01

    Pseudomonas aeruginosa is an important opportunistic pathogen that cause mainly nosocomial infections especially in the immunocompromised patients, the elderly and patients with severe burns. The bacterial feature of developing high degree of resistance against several antibiotics leads to increased morbidity and mortality of P.aeruginosa infections. The aims of this study were to investigate the antibiotic susceptibilities of P.aeruginosa strains isolated from hospitalized patients and to determine the presence of resistance enzymes namely PER, GES, KPC, VIM, IMP and OXA. A total of 195 P.aeruginosa strains isolated from different clinical samples (29 sputum, 67 wound, 53 tracheal aspirate, 23 blood, 18 urine, 3 cerebrospinal fluid, 2 pleural fluid) of inpatients (134 male, 61 female) in Afyon Kocatepe University School of Medicine Hospital between 2010-2012, were included in the study. The isolates were identified by conventional methods and automated systems (VITEK 2, BioMerieux, France), and their antibiotic susceptibilities were detected by disk diffusion and E-test methods. Inducible beta-lactamase (IBL), extended-spectrum beta-lactamase (ESBL) and metallo-beta-lactamase (MBL) productions of the isolates were phenotypically investigated by double disk induction, double disk synergy and E-test methods, respectively. The presence of resistance genes encoding PER, GES, KPC, VIM, IMP and OXA enzymes were determined by real-time polymerase chain reaction, and sequence analysis was applied to positive samples. In our study, the antibiotic resistance rates of 195 P.aeruginosa strains were found as follows: ceftazidime 100%, tazobactam/piperacillin 90.8%, aztreonam 60.5%, cefepime 50.2%, imipenem 48.2%, meropenem 47.2%, ofloxacin 47.2%, piperacillin 44.1%, levofloxacin 31.3%, ciprofloxacin 26.2%, gentamicin 11.8%, amikacin 8.7% and tobramycin 6.2%. With the use of phenotypical methods, IBL, ESBL and MBL production rates in the isolates were detected as 89.2% (174/195), 30.7% (60/195) and 26.7% (52/195), respectively. Molecular studies showed that, five strains harboured OXA-10, four OXA-14, four VIM-2, two IMP-1, 26 GES-1 and 87 ABC transporter permease genes, while PER and KPC genes were not detected in any of the isolates. In conclusion, it was considered that the detection of beta-lactamase genes in bacteria and the identification of beta-lactamase types may provide facilities in selection of antibiotics, monitorization of therapy, prevention of resistance development of infection control programs.

  16. Method of preparing high specific activity platinum-195m

    DOEpatents

    Mirzadeh, Saed; Du, Miting; Beets, Arnold L.; Knapp, Jr., Furn F.

    2004-06-15

    A method of preparing high-specific-activity .sup.195m Pt includes the steps of: exposing .sup.193 Ir to a flux of neutrons sufficient to convert a portion of the .sup.193 Ir to .sup.195m Pt to form an irradiated material; dissolving the irradiated material to form an intermediate solution comprising Ir and Pt; and separating the Pt from the Ir by cation exchange chromatography to produce .sup.195m Pt.

  17. 49 CFR 195.410 - Line markers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Line markers. 195.410 Section 195.410 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY...

  18. A novel and selective inhibitor of PKC ζ potently inhibits human breast cancer metastasis in vitro and in mice.

    PubMed

    Wu, Jing; Liu, Shuye; Fan, Zhijuan; Zhang, Lei; Tian, Yaqiong; Yang, Rui

    2016-06-01

    Cell motility and chemotaxis play pivotal roles in the process of tumor development and metastasis. Protein kinase C ζ (PKC ζ) mediates epidermal growth factor (EGF)-stimulated chemotactic signaling pathway through regulating cytoskeleton rearrangement and cell adhesion. The purpose of this study was to develop anti-PKC ζ therapeutics for breast cancer metastasis. In this study, a novel and high-efficient PKC ζ inhibitor named PKCZI195.17 was screened out through a substrate-specific strategy. MTT assay was used to determine the cell viability of human breast cancer MDA-MB-231, MDA-MB-435, and MCF-7 cells while under PKCZI195.17 treatment. Wound-healing, chemotaxis, and Matrigel invasion assays were performed to detect the effects of PKCZI195.17 on breast cancer cells migration and invasion. Adhesion, actin polymerization, and Western blotting were performed to detect the effects of PKCZI195.17 on cells adhesion and actin polymerization, and explore the downsteam signaling mechanisms involved in PKC ζ inhibition. MDA-MB-231 xenograft was used to measure the in vivo anti-metastasis efficacy of PKCZI195.17. The compound PKCZI195.17 selectively inhibited PKC ζ kinase activity since it failed to inhibit PKC α, PKC β, PKC δ, PKC η, AKT2, as well as FGFR2 activity. PKCZI195.17 significantly impaired spontaneous migration, chemotaxis, and invasion of human breast cancer MDA-MB-231, MDA-MB-435, and MCF-7 cells, while PKCZI195.17 did not obviously inhibited cells viability. PKCZI195.17 also inhibited cells adhesion and actin polymerization through attenuating the phosphorylations of integrin β1, LIMK, and cofilin, which might be the downstream effectors of PKC ζ-mediated chemotaxis in MDA-MB-231 cells. Furthermore, PKCZI195.17 suppressed the breast cancer metastasis and increased the survival time of breast tumor-bearing mice. In summary, PKCZI195.17 was a PKC ζ-specific inhibitor which dampened cancer cell migration and metastasis and may serve as a novel therapeutic drug for breast cancer metastasis.

  19. Paenibacillus sonchi sp. nov., a nitrogen-fixing species isolated from the rhizosphere of Sonchus oleraceus.

    PubMed

    Hong, Yuan-Yuan; Ma, Yu-Chao; Zhou, Yu-Guang; Gao, Fei; Liu, Hong-Can; Chen, San-Feng

    2009-11-01

    A nitrogen-fixing bacterium, designated strain X19-5(T), was isolated from rhizosphere soil of Sonchus oleraceus. Phylogenetic analysis based on a fragment of the nifH gene and the full-length 16S rRNA gene sequence revealed that strain X19-5(T) was a member of the genus Paenibacillus. Strain X19-5(T) showed the highest 16S rRNA gene sequence similarity (98.8 %) with Paenibacillus graminis RSA19(T) and below 97 % similarity with other recognized members of the genus. The level of DNA-DNA relatedness between strain X19-5(T) and P. graminis RSA19(T) was 45.7 %. The DNA G+C content of strain X19-5(T) was 46.8 mol%. The major fatty acids were anteiso-C(15 : 0), C(16 : 0) and iso-C(16 : 0). On the basis of its phenotypic characteristics and the level of DNA-DNA hybridization, strain X19-5(T) is considered to represent a novel species of the genus Paenibacillus, for which the name Paenibacillus sonchi sp. nov. is proposed. The type strain is X19-5(T) (=CCBAU 83901(T)=LMG 24727(T)).

  20. 49 CFR 195.102 - Design temperature.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Design temperature. 195.102 Section 195.102 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements §...

  1. 49 CFR 195.49 - Annual report.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Annual report. 195.49 Section 195.49 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Annual, Accident, and...

  2. 49 CFR 195.54 - Accident reports.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Accident reports. 195.54 Section 195.54 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Annual, Accident, and...

  3. 49 CFR 195.58 - Report submission requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Report submission requirements. 195.58 Section 195.58 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Annual,...

  4. Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion-induced apoptosis through PI3K/Akt/GSK3β pathway in rats.

    PubMed

    Chen, Lin; Wei, Xinbing; Hou, Yunfeng; Liu, Xiaoqian; Li, Senpeng; Sun, Baozhu; Liu, Xinyong; Liu, Huiqing

    2014-01-01

    CXC195 showed strongest protective effects among the ligustrazine derivatives in cells and prevented apoptosis induced by H2O2 injury. We recently demonstrated that CXC195 protected against cerebral ischemia/reperfusion (I/R) injury by its antioxidant activity. However, whether the anti-apoptotic action of CXC195 is involved in cerebral I/R injury is unknown. Here, we investigated the role of CXC195 in apoptotic processes induced by cerebral I/R and the possible signaling pathways. Male Wistar rats were submitted to transient middle cerebral artery occlusion for 2h, followed by 24h reperfusion. CXC195 was injected intraperitoneally at 2h and 12h after the onset of ischemia. The number of apoptotic cells was measured by TUNEL assay, apoptosis-related protein cleaved caspase-3, Bcl-2, Bax and the phosphorylation levels of Akt and GSK3β in ischemic penumbra were assayed by western blot. The results showed that administration of CXC195 at the doses of 3mg/kg and 10mg/kg significantly inhibited the apoptosis by decreasing the number of apoptotic cells, decreasing the level of cleaved caspase-3 and Bax, and increasing the level of Bcl-2 in rats subjected to I/R injury. Simultaneously, CXC195 treatment markedly increased the phosphorylation of Akt and GSK3β. Blockade of PI3K activity by wortmannin, dramatically abolished its anti-apoptotic effect and lowered both Akt and GSK3β phosphorylation levels. Our study firstly demonstrated that CXC195 protected against cerebral I/R injury by reducing apoptosis in vivo and PI3K/Akt/GSK3β pathway involved in the anti-apoptotic effect. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

  5. Biodistribution of radiomercury in rabbits and efficacy of dimercaptopropanesulfonic acid (DMPS) and dimercaprol (BAL) to reduce tracer-level kidney (kid) burden of radiomercury in rats

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Coveney, J.R.; Robbins, M.S.

    There is clinical interest in /sup 195m/Hg//sup 195m/Au generators for radionuclide angiocardiography. Generators are /sup 195m/Hg-impregnated columns through which S/sub 2/O/sub 3//sup 2 -//NO/sub 3//sup -/ eluant is passed to recover /sup 195m/Au daughter (t/sub 1/2p/ approx. 30s) permitting repeated patient study at short intervals, but co-elution of some /sup 195m/Hg (t/sub 1/2p approx. 40h) limits per-study dose: eluate was injected i.v. to male and female New Zealand White rabbits (1.4-2.4 kg, 12 ml eluate ea.); approx. 40% of injected dose (ID) of /sup 195m/Hg was in kids by 3d and approx. 20% ID remained after 14d; only 37% IDmore » was excreted (2/3 in feces) at 7d. To evaluate DMPS action upon kid /sup 195m/Hg burden, male Sprague-Dawley rats (187-240 g) were injected i.v. with 2ml eluate containing 0.02 mg DMPS/ml or eluate alone. DMPS slightly reduced % ID /sup 195m/Hg in kids 22h later: 12.2 +/- 0.3 to 8.5 +/- 0.3 (mean +/- s.e.m., n = 4). Additional rats were given 5 mg BAL/kg, i.p., or 2ml propylene glycol vehicle/kg 3-4' before 2ml eluate, i.v.; % ID of Hg was again only slightly reduced (14.4 +/- 0.2 to 10.7 +/- 0.1). Neither BAL nor DMPS, useful in repeat-dose regimens in heavy metal poisoning, are suitable in single doses for reducing absorbed radiation dose in /sup 195m/Au angiocardiography.« less

  6. Regulation of cell cycle checkpoint kinase WEE1 by miR-195 in malignant melanoma.

    PubMed

    Bhattacharya, A; Schmitz, U; Wolkenhauer, O; Schönherr, M; Raatz, Y; Kunz, M

    2013-06-27

    WEE1 kinase has been described as a major gate keeper at the G2 cell cycle checkpoint and to be involved in tumour progression in different malignant tumours. Here we analysed the expression levels of WEE1 in a series of melanoma patient samples and melanoma cell lines using immunoblotting, quantitative real-time PCR and immunohistochemistry. WEE1 expression was significantly downregulated in patient samples of metastatic origin as compared with primary melanomas and in melanoma cell lines of high aggressiveness as compared with cell lines of low aggressiveness. Moreover, there was an inverse correlation between the expression of WEE1 and WEE1-targeting microRNA miR-195. Further analyses showed that transfection of melanoma cell lines with miR-195 indeed reduced WEE1 mRNA and protein expression in these cells. Reporter gene analysis confirmed direct targeting of the WEE1 3' untranslated region (3'UTR) by miR-195. Overexpression of miR-195 in SK-Mel-28 melanoma cells was accompanied by WEE1 reduction and significantly reduced stress-induced G2-M cell cycle arrest, which could be restored by stable overexpression of WEE1. Moreover, miR-195 overexpression and WEE1 knockdown, respectively, increased melanoma cell proliferation. miR-195 overexpression also enhanced migration and invasiveness of melanoma cells. Taken together, the present study shows that WEE1 expression in malignant melanoma is directly regulated by miR-195. miR-195-mediated downregulation of WEE1 in metastatic lesions may help to overcome cell cycle arrest under stress conditions in the local tissue microenvironment to allow unrestricted growth of tumour cells.

  7. 10 CFR 19.5 - Communications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Communications. 19.5 Section 19.5 Energy NUCLEAR... Communications. Except where otherwise specified in this part, all communications and reports concerning the... Regulatory Commission Regional Office listed in Appendix D of part 20 of this chapter. Communications...

  8. 15 CFR 922.195 - Permit procedures and criteria.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Permit procedures and criteria. 922.195 Section 922.195 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND COASTAL...

  9. 34 CFR 668.195 - Participation rate index appeals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Participation rate index appeals. 668.195 Section 668.195 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION STUDENT ASSISTANCE GENERAL PROVISIONS Two Year Cohort Default...

  10. 10 CFR 19.5 - Communications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Communications. 19.5 Section 19.5 Energy NUCLEAR... Communications. Except where otherwise specified in this part, all communications and reports concerning the... Regulatory Commission Regional Office listed in Appendix D of part 20 of this chapter. Communications...

  11. 10 CFR 19.5 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Communications. 19.5 Section 19.5 Energy NUCLEAR... Communications. Except where otherwise specified in this part, all communications and reports concerning the... Regulatory Commission Regional Office listed in Appendix D of part 20 of this chapter. Communications...

  12. 32 CFR 195.4 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Policy. 195.4 Section 195.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OF THE DEPARTMENT OF DEFENSE-EFFECTUATION OF TITLE VI OF THE CIVIL...

  13. 32 CFR 195.4 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Policy. 195.4 Section 195.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OF THE DEPARTMENT OF DEFENSE-EFFECTUATION OF TITLE VI OF THE CIVIL...

  14. 32 CFR 195.4 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Policy. 195.4 Section 195.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OF THE DEPARTMENT OF DEFENSE-EFFECTUATION OF TITLE VI OF THE CIVIL...

  15. 32 CFR 195.4 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Policy. 195.4 Section 195.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OF THE DEPARTMENT OF DEFENSE-EFFECTUATION OF TITLE VI OF THE CIVIL...

  16. 32 CFR 195.4 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Policy. 195.4 Section 195.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OF THE DEPARTMENT OF DEFENSE-EFFECTUATION OF TITLE VI OF THE CIVIL...

  17. 46 CFR 195.06-1 - Lifesaving appliances and arrangements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Lifesaving appliances and arrangements. 195.06-1 Section... VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Lifesaving Appliances and Arrangements § 195.06-1 Lifesaving appliances and arrangements. All lifesaving appliances and arrangements shall be...

  18. 46 CFR 195.35-20 - Spare charges.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Spare charges. 195.35-20 Section 195.35-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL CONTROL... recharge shall be carried for each self-contained breathing apparatus, and a complete set of spare...

  19. 46 CFR 195.05-1 - Installation and details.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Installation and details. 195.05-1 Section 195.05-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL... Systems. Fire Detecting and Alarm Systems. Sound Powered Telephone and Voice Tube Systems. Engine Order...

  20. 46 CFR 195.05-1 - Installation and details.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Installation and details. 195.05-1 Section 195.05-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL... Systems. Fire Detecting and Alarm Systems. Sound Powered Telephone and Voice Tube Systems. Engine Order...

  1. 46 CFR 195.05-1 - Installation and details.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Installation and details. 195.05-1 Section 195.05-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL... Systems. Fire Detecting and Alarm Systems. Sound Powered Telephone and Voice Tube Systems. Engine Order...

  2. 46 CFR 195.05-1 - Installation and details.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Installation and details. 195.05-1 Section 195.05-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL... Systems. Fire Detecting and Alarm Systems. Sound Powered Telephone and Voice Tube Systems. Engine Order...

  3. 46 CFR 195.11-15 - Plan approval and inspection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Plan approval and inspection. 195.11-15 Section 195.11-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS... and inspection. (a) Accommodation, power and chemical stores vans are subject to normal plan...

  4. 13 CFR 120.195 - Disclosure of fees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Section 120.195 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Policies Applying to All Business Loans Reporting § 120.195 Disclosure of fees. An Applicant for a business loan... applicant obtain the loan, describing the services performed, and disclosing the amount of each fee paid or...

  5. 13 CFR 120.195 - Disclosure of fees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Section 120.195 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Policies Applying to All Business Loans Reporting § 120.195 Disclosure of fees. An Applicant for a business loan... applicant obtain the loan, describing the services performed, and disclosing the amount of each fee paid or...

  6. 13 CFR 120.195 - Disclosure of fees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Section 120.195 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Policies Applying to All Business Loans Reporting § 120.195 Disclosure of fees. An Applicant for a business loan... applicant obtain the loan, describing the services performed, and disclosing the amount of each fee paid or...

  7. 13 CFR 120.195 - Disclosure of fees.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Section 120.195 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Policies Applying to All Business Loans Reporting § 120.195 Disclosure of fees. An Applicant for a business loan... applicant obtain the loan, describing the services performed, and disclosing the amount of each fee paid or...

  8. 13 CFR 120.195 - Disclosure of fees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Section 120.195 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Policies Applying to All Business Loans Reporting § 120.195 Disclosure of fees. An Applicant for a business loan... applicant obtain the loan, describing the services performed, and disclosing the amount of each fee paid or...

  9. 49 CFR 195.256 - Crossing of railroads and highways.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Crossing of railroads and highways. 195.256... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.256 Crossing of railroads and highways. The pipe at each railroad or highway crossing must be installed so as to adequately withstand the dynamic...

  10. 40 CFR 792.195 - Retention of records.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... mutagenicity tests, specimens of soil, water, and plants, and wet specimens of blood, urine, feces, biological... 40 Protection of Environment 32 2011-07-01 2011-07-01 false Retention of records. 792.195 Section... ACT (CONTINUED) GOOD LABORATORY PRACTICE STANDARDS Records and Reports § 792.195 Retention of records...

  11. 40 CFR 792.195 - Retention of records.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... mutagenicity tests, specimens of soil, water, and plants, and wet specimens of blood, urine, feces, biological... 40 Protection of Environment 32 2014-07-01 2014-07-01 false Retention of records. 792.195 Section... ACT (CONTINUED) GOOD LABORATORY PRACTICE STANDARDS Records and Reports § 792.195 Retention of records...

  12. 40 CFR 160.195 - Retention of records.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... obtained from mutagenicity tests, specimens of soil, water, and plants, and wet specimens of blood, urine... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Retention of records. 160.195 Section... LABORATORY PRACTICE STANDARDS Records and Reports § 160.195 Retention of records. (a) Record retention...

  13. 40 CFR 160.195 - Retention of records.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... obtained from mutagenicity tests, specimens of soil, water, and plants, and wet specimens of blood, urine... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Retention of records. 160.195 Section... LABORATORY PRACTICE STANDARDS Records and Reports § 160.195 Retention of records. (a) Record retention...

  14. 40 CFR 160.195 - Retention of records.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... obtained from mutagenicity tests, specimens of soil, water, and plants, and wet specimens of blood, urine... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Retention of records. 160.195 Section... LABORATORY PRACTICE STANDARDS Records and Reports § 160.195 Retention of records. (a) Record retention...

  15. 40 CFR 792.195 - Retention of records.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... mutagenicity tests, specimens of soil, water, and plants, and wet specimens of blood, urine, feces, biological... 40 Protection of Environment 33 2012-07-01 2012-07-01 false Retention of records. 792.195 Section... ACT (CONTINUED) GOOD LABORATORY PRACTICE STANDARDS Records and Reports § 792.195 Retention of records...

  16. 40 CFR 792.195 - Retention of records.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... mutagenicity tests, specimens of soil, water, and plants, and wet specimens of blood, urine, feces, biological... 40 Protection of Environment 33 2013-07-01 2013-07-01 false Retention of records. 792.195 Section... ACT (CONTINUED) GOOD LABORATORY PRACTICE STANDARDS Records and Reports § 792.195 Retention of records...

  17. 40 CFR 160.195 - Retention of records.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... obtained from mutagenicity tests, specimens of soil, water, and plants, and wet specimens of blood, urine... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Retention of records. 160.195 Section... LABORATORY PRACTICE STANDARDS Records and Reports § 160.195 Retention of records. (a) Record retention...

  18. 21 CFR 1271.195 - Environmental control and monitoring.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Environmental control and monitoring. 1271.195 Section 1271.195 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) REGULATIONS UNDER CERTAIN OTHER ACTS ADMINISTERED BY THE FOOD AND DRUG ADMINISTRATION HUMAN CELLS...

  19. 41 CFR 102-85.195 - Does GSA provide special services?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Does GSA provide special services? 102-85.195 Section 102-85.195 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 85-PRICING POLICY FOR...

  20. 9 CFR 381.195 - Definitions; requirements for importation into the United States.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... importation into the United States. 381.195 Section 381.195 Animals and Animal Products FOOD SAFETY AND... thereof, shall be imported into the United States unless they are healthful, wholesome, fit for human food, not adulterated, and contain no dye, chemical, preservative, or ingredient which renders them...

  1. 9 CFR 381.195 - Definitions; requirements for importation into the United States.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... importation into the United States. 381.195 Section 381.195 Animals and Animal Products FOOD SAFETY AND... thereof, shall be imported into the United States unless they are healthful, wholesome, fit for human food, not adulterated, and contain no dye, chemical, preservative, or ingredient which renders them...

  2. 9 CFR 381.195 - Definitions; requirements for importation into the United States.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... importation into the United States. 381.195 Section 381.195 Animals and Animal Products FOOD SAFETY AND... thereof, shall be imported into the United States unless they are healthful, wholesome, fit for human food, not adulterated, and contain no dye, chemical, preservative, or ingredient which renders them...

  3. 9 CFR 381.195 - Definitions; requirements for importation into the United States.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... importation into the United States. 381.195 Section 381.195 Animals and Animal Products FOOD SAFETY AND... thereof, shall be imported into the United States unless they are healthful, wholesome, fit for human food, not adulterated, and contain no dye, chemical, preservative, or ingredient which renders them...

  4. 21 CFR 133.195 - Swiss and emmentaler cheese.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Swiss and emmentaler cheese. 133.195 Section 133...) FOOD FOR HUMAN CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized Cheese and Related Products § 133.195 Swiss and emmentaler cheese. (a) Description. (1) Swiss cheese...

  5. 21 CFR 133.195 - Swiss and emmentaler cheese.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Swiss and emmentaler cheese. 133.195 Section 133...) FOOD FOR HUMAN CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized Cheese and Related Products § 133.195 Swiss and emmentaler cheese. (a) Description. (1) Swiss cheese...

  6. 49 CFR 195.4 - Compatibility necessary for transportation of hazardous liquids or carbon dioxide.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Compatibility necessary for transportation of hazardous liquids or carbon dioxide. 195.4 Section 195.4 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY...

  7. 49 CFR 195.4 - Compatibility necessary for transportation of hazardous liquids or carbon dioxide.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Compatibility necessary for transportation of hazardous liquids or carbon dioxide. 195.4 Section 195.4 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY...

  8. 49 CFR 195.4 - Compatibility necessary for transportation of hazardous liquids or carbon dioxide.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Compatibility necessary for transportation of hazardous liquids or carbon dioxide. 195.4 Section 195.4 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY...

  9. 27 CFR 19.5 - Manufacturing products unfit for beverage use.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... qualify as a distilled spirits plant (processor): (1) Medicines, medicinal preparations, food products... beverage purposes; (3) Toilet, medicinal, and antiseptic preparations and solutions that are unfit for use... unfit for beverage use. 19.5 Section 19.5 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX...

  10. 49 CFR 195.52 - Telephonic notice of certain accidents.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Telephonic notice of certain accidents. 195.52... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Annual, Accident, and Safety-Related Condition Reporting § 195.52 Telephonic notice of certain accidents. (a) At the earliest practicable moment following discovery of a...

  11. 49 CFR 195.52 - Immediate notice of certain accidents.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Immediate notice of certain accidents. 195.52... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Annual, Accident, and Safety-Related Condition Reporting § 195.52 Immediate notice of certain accidents. (a) Notice requirements. At the earliest practicable moment following...

  12. 46 CFR 108.195 - Location of accommodation spaces.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Location of accommodation spaces. 108.195 Section 108... DESIGN AND EQUIPMENT Construction and Arrangement Accommodation Spaces § 108.195 Location of accommodation spaces. (a) On surface type units, accommodation spaces must not be located forward of a vertical...

  13. 46 CFR 108.195 - Location of accommodation spaces.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Location of accommodation spaces. 108.195 Section 108... DESIGN AND EQUIPMENT Construction and Arrangement Accommodation Spaces § 108.195 Location of accommodation spaces. (a) On surface type units, accommodation spaces must not be located forward of a vertical...

  14. 46 CFR 108.195 - Location of accommodation spaces.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Location of accommodation spaces. 108.195 Section 108... DESIGN AND EQUIPMENT Construction and Arrangement Accommodation Spaces § 108.195 Location of accommodation spaces. (a) On surface type units, accommodation spaces must not be located forward of a vertical...

  15. 46 CFR 108.195 - Location of accommodation spaces.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Location of accommodation spaces. 108.195 Section 108... DESIGN AND EQUIPMENT Construction and Arrangement Accommodation Spaces § 108.195 Location of accommodation spaces. (a) On surface type units, accommodation spaces must not be located forward of a vertical...

  16. 46 CFR 108.195 - Location of accommodation spaces.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Location of accommodation spaces. 108.195 Section 108... DESIGN AND EQUIPMENT Construction and Arrangement Accommodation Spaces § 108.195 Location of accommodation spaces. (a) On surface type units, accommodation spaces must not be located forward of a vertical...

  17. 49 CFR 195.563 - Which pipelines must have cathodic protection?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Which pipelines must have cathodic protection? 195... have cathodic protection? (a) Each buried or submerged pipeline that is constructed, relocated, replaced, or otherwise changed after the applicable date in § 195.401(c) must have cathodic protection. The...

  18. 49 CFR 195.563 - Which pipelines must have cathodic protection?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Which pipelines must have cathodic protection? 195... have cathodic protection? (a) Each buried or submerged pipeline that is constructed, relocated, replaced, or otherwise changed after the applicable date in § 195.401(c) must have cathodic protection. The...

  19. 49 CFR 195.256 - Crossing of railroads and highways.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Crossing of railroads and highways. 195.256... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.256 Crossing of railroads and highways. The pipe at each railroad or highway crossing must be installed so as to adequately withstand the dynamic...

  20. 49 CFR 195.256 - Crossing of railroads and highways.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Crossing of railroads and highways. 195.256... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.256 Crossing of railroads and highways. The pipe at each railroad or highway crossing must be installed so as to adequately withstand the dynamic...

  1. 49 CFR 195.256 - Crossing of railroads and highways.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Crossing of railroads and highways. 195.256... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.256 Crossing of railroads and highways. The pipe at each railroad or highway crossing must be installed so as to adequately withstand the dynamic...

  2. 49 CFR 195.256 - Crossing of railroads and highways.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Crossing of railroads and highways. 195.256... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.256 Crossing of railroads and highways. The pipe at each railroad or highway crossing must be installed so as to adequately withstand the dynamic...

  3. 9 CFR 381.195 - Definitions; requirements for importation into the United States.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Definitions; requirements for importation into the United States. 381.195 Section 381.195 Animals and Animal Products FOOD SAFETY AND...

  4. 37 CFR 2.195 - Receipt of trademark correspondence.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... correspondence. 2.195 Section 2.195 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES General Information and Correspondence in... be given a filing date as of the date of deposit as “Express Mail” with the United States Postal...

  5. 46 CFR 195.30-15 - Self-contained breathing apparatus.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Self-contained breathing apparatus. 195.30-15 Section... VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Protection From Refrigerants § 195.30-15 Self-contained breathing apparatus. (a) Each vessel must have a self-contained breathing apparatus for...

  6. 46 CFR 195.30-15 - Self-contained breathing apparatus.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Self-contained breathing apparatus. 195.30-15 Section... VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Protection From Refrigerants § 195.30-15 Self-contained breathing apparatus. (a) Each vessel must have a self-contained breathing apparatus for...

  7. High specific activity platinum-195m

    DOEpatents

    Mirzadeh, Saed; Du, Miting; Beets, Arnold L.; Knapp, Jr., Furn F.

    2004-10-12

    A new composition of matter includes .sup.195m Pt characterized by a specific activity of at least 30 mCi/mg Pt, generally made by method that includes the steps of: exposing .sup.193 Ir to a flux of neutrons sufficient to convert a portion of the .sup.193 Ir to .sup.195m Pt to form an irradiated material; dissolving the irradiated material to form an intermediate solution comprising Ir and Pt; and separating the Pt from the Ir by cation exchange chromatography to produce .sup.195m Pt.

  8. 14 CFR 21.195 - Experimental certificates: Aircraft to be used for market surveys, sales demonstrations, and...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... used for market surveys, sales demonstrations, and customer crew training. 21.195 Section 21.195... be used for market surveys, sales demonstrations, and customer crew training. (a) A manufacturer of... that is to be used for market surveys, sales demonstrations, or customer crew training. (b) A...

  9. 14 CFR 21.195 - Experimental certificates: Aircraft to be used for market surveys, sales demonstrations, and...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... used for market surveys, sales demonstrations, and customer crew training. 21.195 Section 21.195... be used for market surveys, sales demonstrations, and customer crew training. (a) A manufacturer of... that is to be used for market surveys, sales demonstrations, or customer crew training. (b) A...

  10. 14 CFR 21.195 - Experimental certificates: Aircraft to be used for market surveys, sales demonstrations, and...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... used for market surveys, sales demonstrations, and customer crew training. 21.195 Section 21.195... be used for market surveys, sales demonstrations, and customer crew training. (a) A manufacturer of... that is to be used for market surveys, sales demonstrations, or customer crew training. (b) A...

  11. 14 CFR 21.195 - Experimental certificates: Aircraft to be used for market surveys, sales demonstrations, and...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... used for market surveys, sales demonstrations, and customer crew training. 21.195 Section 21.195... be used for market surveys, sales demonstrations, and customer crew training. (a) A manufacturer of... that is to be used for market surveys, sales demonstrations, or customer crew training. (b) A...

  12. 45 CFR 286.195 - What penalties will apply to Tribes?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 2 2012-10-01 2012-10-01 false What penalties will apply to Tribes? 286.195... TRIBAL TANF PROVISIONS Accountability and Penalties § 286.195 What penalties will apply to Tribes? (a) Tribes will be subject to fiscal penalties and requirements as follows: (1) If we determine that a Tribe...

  13. 45 CFR 286.195 - What penalties will apply to Tribes?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false What penalties will apply to Tribes? 286.195... TRIBAL TANF PROVISIONS Accountability and Penalties § 286.195 What penalties will apply to Tribes? (a) Tribes will be subject to fiscal penalties and requirements as follows: (1) If we determine that a Tribe...

  14. 45 CFR 286.195 - What penalties will apply to Tribes?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 2 2013-10-01 2012-10-01 true What penalties will apply to Tribes? 286.195... TRIBAL TANF PROVISIONS Accountability and Penalties § 286.195 What penalties will apply to Tribes? (a) Tribes will be subject to fiscal penalties and requirements as follows: (1) If we determine that a Tribe...

  15. 45 CFR 286.195 - What penalties will apply to Tribes?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true What penalties will apply to Tribes? 286.195... TRIBAL TANF PROVISIONS Accountability and Penalties § 286.195 What penalties will apply to Tribes? (a) Tribes will be subject to fiscal penalties and requirements as follows: (1) If we determine that a Tribe...

  16. 49 CFR 195.3 - Incorporation by reference.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Fittings Industry, Inc. (MSS), 127 Park Street, NE., Vienna, VA 22180. 5. American Society for Testing and...)) §§ 195.205(b)(1); 195.432(b). (12) API Standard 1104, “Welding of Pipelines and Related Facilities” (20th....307(e). (7) 2007 ASME Boiler & Pressure Vessel Code, Section IX: “Qualification Standard for Welding...

  17. 46 CFR 195.07-5 - Ocean, coastwise, or Great Lakes service.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Ocean, coastwise, or Great Lakes service. 195.07-5 Section 195.07-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Ocean, coastwise, or Great Lakes service. (a) Vessels in ocean, coastwise, or Great Lakes service shall...

  18. 46 CFR 195.07-5 - Ocean, coastwise, or Great Lakes service.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Ocean, coastwise, or Great Lakes service. 195.07-5 Section 195.07-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Ocean, coastwise, or Great Lakes service. (a) Vessels in ocean, coastwise, or Great Lakes service shall...

  19. 46 CFR 195.07-5 - Ocean, coastwise, or Great Lakes service.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Ocean, coastwise, or Great Lakes service. 195.07-5 Section 195.07-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Ocean, coastwise, or Great Lakes service. (a) Vessels in ocean, coastwise, or Great Lakes service shall...

  20. 46 CFR 195.07-5 - Ocean, coastwise, or Great Lakes service.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Ocean, coastwise, or Great Lakes service. 195.07-5 Section 195.07-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Ocean, coastwise, or Great Lakes service. (a) Vessels in ocean, coastwise, or Great Lakes service shall...

  1. 46 CFR 195.07-5 - Ocean, coastwise, or Great Lakes service.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Ocean, coastwise, or Great Lakes service. 195.07-5 Section 195.07-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Ocean, coastwise, or Great Lakes service. (a) Vessels in ocean, coastwise, or Great Lakes service shall...

  2. 49 CFR 195.4 - Compatibility necessary for transportation of hazardous liquids or carbon dioxide.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... hazardous liquids or carbon dioxide. 195.4 Section 195.4 Transportation Other Regulations Relating to... necessary for transportation of hazardous liquids or carbon dioxide. No person may transport any hazardous liquid or carbon dioxide unless the hazardous liquid or carbon dioxide is chemically compatible with both...

  3. 49 CFR 195.4 - Compatibility necessary for transportation of hazardous liquids or carbon dioxide.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... hazardous liquids or carbon dioxide. 195.4 Section 195.4 Transportation Other Regulations Relating to... necessary for transportation of hazardous liquids or carbon dioxide. No person may transport any hazardous liquid or carbon dioxide unless the hazardous liquid or carbon dioxide is chemically compatible with both...

  4. 46 CFR 195.11-20 - Marking and label plate.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Marking and label plate. 195.11-20 Section 195.11-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL... plate. (a) All vans shall be provided with a label plate stating light weight, gross weight, and power...

  5. 46 CFR 195.07-10 - Lakes, bays, and sounds, or river service.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Lakes, bays, and sounds, or river service. 195.07-10 Section 195.07-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Lakes, bays, and sounds, or river service. (a) Vessels in lakes, bays, and sounds, or river service...

  6. 49 CFR 195.264 - Impoundment, protection against entry, normal/emergency venting or pressure/vacuum relief for...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... devices must be provided for each low-pressure and high-pressure breakout tank. (e) For normal/emergency... and vacuum-relieving devices installed on high pressure tanks built to API Standard 2510 (incorporated.../emergency venting or pressure/vacuum relief for aboveground breakout tanks. 195.264 Section 195.264...

  7. 46 CFR 195.07-10 - Lakes, bays, and sounds, or river service.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Lakes, bays, and sounds, or river service. 195.07-10 Section 195.07-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Lakes, bays, and sounds, or river service. (a) Vessels in lakes, bays, and sounds, or river service...

  8. 46 CFR 195.07-10 - Lakes, bays, and sounds, or river service.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Lakes, bays, and sounds, or river service. 195.07-10 Section 195.07-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Lakes, bays, and sounds, or river service. (a) Vessels in lakes, bays, and sounds, or river service...

  9. 46 CFR 195.07-10 - Lakes, bays, and sounds, or river service.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Lakes, bays, and sounds, or river service. 195.07-10 Section 195.07-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Lakes, bays, and sounds, or river service. (a) Vessels in lakes, bays, and sounds, or river service...

  10. 7 CFR 4280.195 - Awarding and administering energy audit and renewable energy development assistance grants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Awarding and administering energy audit and renewable energy development assistance grants. 4280.195 Section 4280.195 Agriculture Regulations of the Department... OF AGRICULTURE LOANS AND GRANTS Rural Energy for America Program General Energy Audit and Renewable...

  11. 49 CFR Appendix B to Part 195 - Risk-Based Alternative to Pressure Testing Older Hazardous Liquid and Carbon Dioxide Pipelines

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) (Propane, butane, Natural Gas Liquid (NGL), ammonia) Highly toxic (Benzene, high Hydrogen Sulfide content... Hazardous Liquid and Carbon Dioxide Pipelines B Appendix B to Part 195 Transportation Other Regulations... OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pt. 195...

  12. 49 CFR Appendix B to Part 195 - Risk-Based Alternative to Pressure Testing Older Hazardous Liquid and Carbon Dioxide Pipelines

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) (Propane, butane, Natural Gas Liquid (NGL), ammonia) Highly toxic (Benzene, high Hydrogen Sulfide content... Hazardous Liquid and Carbon Dioxide Pipelines B Appendix B to Part 195 Transportation Other Regulations... OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pt. 195...

  13. 49 CFR Appendix B to Part 195 - Risk-Based Alternative to Pressure Testing Older Hazardous Liquid and Carbon Dioxide Pipelines

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) (Propane, butane, Natural Gas Liquid (NGL), ammonia) Highly toxic (Benzene, high Hydrogen Sulfide content... Hazardous Liquid and Carbon Dioxide Pipelines B Appendix B to Part 195 Transportation Other Regulations... OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pt. 195...

  14. 49 CFR Appendix B to Part 195 - Risk-Based Alternative to Pressure Testing Older Hazardous Liquid and Carbon Dioxide Pipelines

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) (Propane, butane, Natural Gas Liquid (NGL), ammonia) Highly toxic (Benzene, high Hydrogen Sulfide content... Hazardous Liquid and Carbon Dioxide Pipelines B Appendix B to Part 195 Transportation Other Regulations... OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pt. 195...

  15. 49 CFR Appendix B to Part 195 - Risk-Based Alternative to Pressure Testing Older Hazardous Liquid and Carbon Dioxide Pipelines

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) (Propane, butane, Natural Gas Liquid (NGL), ammonia) Highly toxic (Benzene, high Hydrogen Sulfide content... Hazardous Liquid and Carbon Dioxide Pipelines B Appendix B to Part 195 Transportation Other Regulations... OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pt. 195...

  16. 49 CFR 195.551 - What do the regulations in this subpart cover?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false What do the regulations in this subpart cover? 195... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.551 What do the regulations in this subpart cover? This subpart prescribes minimum requirements for protecting steel pipelines...

  17. 46 CFR 195.07-10 - Lakes, bays, and sounds, or river service.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Lakes, bays, and sounds, or river service. 195.07-10 Section 195.07-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Lakes, bays, and sounds, or river service. (a) Vessels in lakes, bays, and sounds, or river service...

  18. 34 CFR 403.195 - What are the administrative cost requirements applicable to local recipients?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false What are the administrative cost requirements applicable to local recipients? 403.195 Section 403.195 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE...

  19. 34 CFR 403.195 - What are the administrative cost requirements applicable to local recipients?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false What are the administrative cost requirements applicable to local recipients? 403.195 Section 403.195 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE...

  20. 34 CFR 403.195 - What are the administrative cost requirements applicable to local recipients?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false What are the administrative cost requirements applicable to local recipients? 403.195 Section 403.195 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE...

  1. 34 CFR 403.195 - What are the administrative cost requirements applicable to local recipients?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false What are the administrative cost requirements applicable to local recipients? 403.195 Section 403.195 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE...

  2. Ultra-Sensitive Biological Detection via Nanoparticle-Based Magnetically Amplified Surface Plasmon Resonance (Mag-SPR) Techniques

    DTIC Science & Technology

    2008-10-08

    of reactant to ferrocene and xylene, a liquid carbon source, results in longer nanostructures in larger amount as shown in Fig. 2(g). These samples...with 6.5 mol% ferrocene and 100 mol% xylene. The flow rate was (e) 0.195 ml/hr, (f) 0.98 ml/hr, and (g) 1.95 ml/hr. (d) and (h) are HR-TEM images of...and ferrocene . The flow rate was (a) 0.195 ml/hr and (b) 1.95 ml/hr........................ 19  Fig. A-5. STEM EDS analysis of the CF specimen after

  3. 14 CFR 21.195 - Experimental certificates: Aircraft to be used for market surveys, sales demonstrations, and...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... used for market surveys, sales demonstrations, and customer crew training. 21.195 Section 21.195... be used for market surveys, sales demonstrations, and customer crew training. Link to an amendment... States may apply for an experimental certificate for an aircraft that is to be used for market surveys...

  4. 41 CFR 102-36.195 - What type of excess personal property may we furnish to our project grantees?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What type of excess personal property may we furnish to our project grantees? 102-36.195 Section 102-36.195 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT...

  5. 46 CFR 174.195 - Bulkheads in machinery spaces.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Bulkheads in machinery spaces. 174.195 Section 174.195... in machinery spaces. (a) The bulkhead in each machinery space of each OSV must be watertight to the bulkhead deck. (b) Each penetration of, and each opening in, a bulkhead in a machinery space must— (1) Be...

  6. 46 CFR 174.195 - Bulkheads in machinery spaces.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Bulkheads in machinery spaces. 174.195 Section 174.195... in machinery spaces. (a) The bulkhead in each machinery space of each OSV must be watertight to the bulkhead deck. (b) Each penetration of, and each opening in, a bulkhead in a machinery space must— (1) Be...

  7. 46 CFR 174.195 - Bulkheads in machinery spaces.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Bulkheads in machinery spaces. 174.195 Section 174.195... in machinery spaces. (a) The bulkhead in each machinery space of each OSV must be watertight to the bulkhead deck. (b) Each penetration of, and each opening in, a bulkhead in a machinery space must— (1) Be...

  8. 46 CFR 174.195 - Bulkheads in machinery spaces.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Bulkheads in machinery spaces. 174.195 Section 174.195... in machinery spaces. (a) The bulkhead in each machinery space of each OSV must be watertight to the bulkhead deck. (b) Each penetration of, and each opening in, a bulkhead in a machinery space must— (1) Be...

  9. 46 CFR 174.195 - Bulkheads in machinery spaces.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Bulkheads in machinery spaces. 174.195 Section 174.195... in machinery spaces. (a) The bulkhead in each machinery space of each OSV must be watertight to the bulkhead deck. (b) Each penetration of, and each opening in, a bulkhead in a machinery space must— (1) Be...

  10. 28 CFR 19.5 - Report to the Office of Juvenile Justice and Delinquency Prevention.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Report to the Office of Juvenile Justice and Delinquency Prevention. 19.5 Section 19.5 Judicial Administration DEPARTMENT OF JUSTICE USE OF... Justice and Delinquency Prevention. DOJ will compile and submit to OJJDP, by June 30, 1987, a consolidated...

  11. 49 CFR 195.62 - Supplies of accident report DOT Form 7000-1.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Department will, upon request, furnish specimen copies of the form. Requests should be addressed to the... 49 Transportation 3 2010-10-01 2010-10-01 false Supplies of accident report DOT Form 7000-1. 195... Reporting § 195.62 Supplies of accident report DOT Form 7000-1. Each operator shall maintain an adequate...

  12. 46 CFR 154.195 - Aluminum cargo tank: Steel enclosure.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Equipment Hull Structure § 154.195 Aluminum cargo tank: Steel enclosure. (a) An aluminum cargo tank and its dome must be enclosed by the vessel's hull structure or a separate steel cover. (b) The steel cover for... 46 Shipping 5 2012-10-01 2012-10-01 false Aluminum cargo tank: Steel enclosure. 154.195 Section...

  13. 46 CFR 154.195 - Aluminum cargo tank: Steel enclosure.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Equipment Hull Structure § 154.195 Aluminum cargo tank: Steel enclosure. (a) An aluminum cargo tank and its dome must be enclosed by the vessel's hull structure or a separate steel cover. (b) The steel cover for... 46 Shipping 5 2013-10-01 2013-10-01 false Aluminum cargo tank: Steel enclosure. 154.195 Section...

  14. 46 CFR 154.195 - Aluminum cargo tank: Steel enclosure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Equipment Hull Structure § 154.195 Aluminum cargo tank: Steel enclosure. (a) An aluminum cargo tank and its dome must be enclosed by the vessel's hull structure or a separate steel cover. (b) The steel cover for... 46 Shipping 5 2010-10-01 2010-10-01 false Aluminum cargo tank: Steel enclosure. 154.195 Section...

  15. 46 CFR 154.195 - Aluminum cargo tank: Steel enclosure.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Equipment Hull Structure § 154.195 Aluminum cargo tank: Steel enclosure. (a) An aluminum cargo tank and its dome must be enclosed by the vessel's hull structure or a separate steel cover. (b) The steel cover for... 46 Shipping 5 2014-10-01 2014-10-01 false Aluminum cargo tank: Steel enclosure. 154.195 Section...

  16. 46 CFR 154.195 - Aluminum cargo tank: Steel enclosure.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Equipment Hull Structure § 154.195 Aluminum cargo tank: Steel enclosure. (a) An aluminum cargo tank and its dome must be enclosed by the vessel's hull structure or a separate steel cover. (b) The steel cover for... 46 Shipping 5 2011-10-01 2011-10-01 false Aluminum cargo tank: Steel enclosure. 154.195 Section...

  17. Sustainable growth of Dehalococcoides mccartyi 195 by corrinoid salvaging and remodeling in defined lactate-fermenting consortia.

    PubMed

    Men, Yujie; Seth, Erica C; Yi, Shan; Allen, Robert H; Taga, Michiko E; Alvarez-Cohen, Lisa

    2014-04-01

    Corrinoids are essential cofactors of reductive dehalogenases in Dehalococcoides mccartyi, an important bacterium in bioremediation, yet sequenced D. mccartyi strains do not possess the complete pathway for de novo corrinoid biosynthesis. Pelosinus sp. and Desulfovibrio sp. have been detected in dechlorinating communities enriched from contaminated groundwater without exogenous cobalamin corrinoid. To investigate the corrinoid-related interactions among key members of these communities, we constructed consortia by growing D. mccartyi strain 195 (Dhc195) in cobalamin-free, trichloroethene (TCE)- and lactate-amended medium in cocultures with Desulfovibrio vulgaris Hildenborough (DvH) or Pelosinus fermentans R7 (PfR7) and with both in tricultures. Only the triculture exhibited sustainable dechlorination and cell growth when a physiological level of 5,6-dimethylbenzimidazole (DMB), the lower ligand of cobalamin, was provided. In the triculture, DvH provided hydrogen while PfR7 provided corrinoids to Dhc195, and the initiation of dechlorination and Dhc195 cell growth was highly dependent on the growth of PfR7. Corrinoid analysis indicated that Dhc195 imported and remodeled the phenolic corrinoids produced by PfR7 into cobalamin in the presence of DMB. Transcriptomic analyses of Dhc195 showed the induction of the CbiZ-dependent corrinoid-remodeling pathway and BtuFCD corrinoid ABC transporter genes during corrinoid salvaging and remodeling. In contrast, another operon annotated to encode a putative iron/cobalamin ABC transporter (DET1174-DET1176) was induced when cobalamin was exogenously provided. Interestingly, a global upregulation of phage-related genes was observed when PfR7 was present. These findings provide insights into both the gene regulation of corrinoid salvaging and remodeling in Dhc195 when it is grown without exogenous cobalamin and microbe-to-microbe interactions in dechlorinating microbial communities.

  18. A theoretical elucidation of glucose interaction with HSA's domains.

    PubMed

    Nasiri, Rasoul; Bahrami, Homayoon; Zahedi, Mansour; Moosavi-Movahedi, Ali Akbar; Sattarahmady, Naghmeh

    2010-10-01

    The interaction of different domains belonging to Human Serum Albumin (HSA) with open form of glucose have been investigated using molecular dynamics simulation methods. Applying docking, primary structures involving interaction of some residues with glucose have been obtained. Subsequently, equilibrium geometries at 300 K and minimum geometries have been determined for each of aforementioned structures by employing MD simulation and simulated annealing. The stability of species has been evaluated using a SAWSA v2.0 model. Ultimately, NBO analysis has been carried out to specify possible hydrogen bonding regarding the HSA interaction with glucose. Results obtained show that glucose can interact with Lys195, Lys199, and Glu153. In these interactions, each lysine forms an H-bonding with glucose. The H-bonding is obtained by stretching of N-H bond belonging to NH(3)(+) group of lysine along an oxygen atom of glucose. In addition, the above mentioned lysines are protonated, and there is an electrostatic interaction between glucose with Lys195 or Lys199. In addition, an H-bonding is formed between O atom of -COO group belonging to Glu153 and H atom of OH group belonging to glucose. Because, the N-H group of Lys195 interacts with the O atom of latter OH group, reaction of Lys195 is more desirable than that of Lys199. In fact, glucose is placed in the vicinity of Lys195 along with electrostatic interaction and H-bonding to Lys195 and Lys199 as well as H-bonding with Glu153, which subsequently reacts with Lys195. Thus, Lys195 is the primary site in reaction of glucose with HSA.

  19. 15 CFR 19.5 - How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce debt? 19.5 Section 19.5 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect Commerce...

  20. 15 CFR 19.5 - How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce debt? 19.5 Section 19.5 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect Commerce...

  1. 15 CFR 19.5 - How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce debt? 19.5 Section 19.5 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect Commerce...

  2. 15 CFR 19.5 - How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce debt? 19.5 Section 19.5 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect Commerce...

  3. 15 CFR 19.5 - How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce debt? 19.5 Section 19.5 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect Commerce...

  4. 49 CFR 37.195 - Purchase or lease of OTRBs by private entities not primarily in the business of transporting people.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... primarily in the business of transporting people. 37.195 Section 37.195 Transportation Office of the... transporting people. This section applies to all purchases or leases of new vehicles by private entities which are not primarily engaged in the business of transporting people, with respect to buses delivered to...

  5. 32 CFR Appendix A to Part 195 - Programs to Which This Part Applies

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-EFFECTUATION OF TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 Pt. 195, App. A Appendix A to Part 195—Programs to... Defense assistance to programs of adult education in civil defense subjects (50 United States Code App. 2281 (e), (f)). 6. Office of Civil Defense radiological instruments grants (50 United States Code App...

  6. 32 CFR Appendix A to Part 195 - Programs to Which This Part Applies

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-EFFECTUATION OF TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 Pt. 195, App. A Appendix A to Part 195—Programs to... Defense assistance to programs of adult education in civil defense subjects (50 United States Code App. 2281 (e), (f)). 6. Office of Civil Defense radiological instruments grants (50 United States Code App...

  7. 49 CFR 195.11 - What is a regulated rural gathering line and what requirements apply?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... established under § 195.406 corresponding to— (i) A stress level greater than 20-percent of the specified minimum yield strength of the line pipe; or (ii) If the stress level is unknown or the pipeline is not....410. (7) Establish a continuing public education program in compliance with § 195.440 before...

  8. 49 CFR 195.11 - What is a regulated rural gathering line and what requirements apply?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... established under § 195.406 corresponding to— (i) A stress level greater than 20-percent of the specified minimum yield strength of the line pipe; or (ii) If the stress level is unknown or the pipeline is not....410. (7) Establish a continuing public education program in compliance with § 195.440 before...

  9. 49 CFR 195.11 - What is a regulated rural gathering line and what requirements apply?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... established under § 195.406 corresponding to— (i) A stress level greater than 20-percent of the specified minimum yield strength of the line pipe; or (ii) If the stress level is unknown or the pipeline is not....410. (7) Establish a continuing public education program in compliance with § 195.440 before...

  10. 49 CFR 195.581 - Which pipelines must I protect against atmospheric corrosion and what coating material may I use?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the prevention of atmospheric corrosion. (c) Except portions of pipelines in offshore splash zones or... corrosion will— (1) Only be a light surface oxide; or (2) Not affect the safe operation of the pipeline... corrosion and what coating material may I use? 195.581 Section 195.581 Transportation Other Regulations...

  11. 49 CFR 195.581 - Which pipelines must I protect against atmospheric corrosion and what coating material may I use?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... the prevention of atmospheric corrosion. (c) Except portions of pipelines in offshore splash zones or... corrosion will— (1) Only be a light surface oxide; or (2) Not affect the safe operation of the pipeline... corrosion and what coating material may I use? 195.581 Section 195.581 Transportation Other Regulations...

  12. 49 CFR 195.8 - Transportation of hazardous liquid or carbon dioxide in pipelines constructed with other than...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... dioxide in pipelines constructed with other than steel pipe. 195.8 Section 195.8 Transportation Other... than steel pipe. No person may transport any hazardous liquid or carbon dioxide through a pipe that is... other than steel unless the person has notified the Administrator in writing at least 90 days before the...

  13. 49 CFR 195.8 - Transportation of hazardous liquid or carbon dioxide in pipelines constructed with other than...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... dioxide in pipelines constructed with other than steel pipe. 195.8 Section 195.8 Transportation Other... than steel pipe. No person may transport any hazardous liquid or carbon dioxide through a pipe that is... other than steel unless the person has notified the Administrator in writing at least 90 days before the...

  14. 49 CFR 195.8 - Transportation of hazardous liquid or carbon dioxide in pipelines constructed with other than...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... dioxide in pipelines constructed with other than steel pipe. 195.8 Section 195.8 Transportation Other... than steel pipe. No person may transport any hazardous liquid or carbon dioxide through a pipe that is... other than steel unless the person has notified the Administrator in writing at least 90 days before the...

  15. 49 CFR 195.8 - Transportation of hazardous liquid or carbon dioxide in pipelines constructed with other than...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... dioxide in pipelines constructed with other than steel pipe. 195.8 Section 195.8 Transportation Other... than steel pipe. No person may transport any hazardous liquid or carbon dioxide through a pipe that is... other than steel unless the person has notified the Administrator in writing at least 90 days before the...

  16. 49 CFR 195.8 - Transportation of hazardous liquid or carbon dioxide in pipelines constructed with other than...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... dioxide in pipelines constructed with other than steel pipe. 195.8 Section 195.8 Transportation Other... than steel pipe. No person may transport any hazardous liquid or carbon dioxide through a pipe that is... other than steel unless the person has notified the Administrator in writing at least 90 days before the...

  17. 49 CFR 37.195 - Purchase or lease of OTRBs by private entities not primarily in the business of transporting people.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... primarily in the business of transporting people. 37.195 Section 37.195 Transportation Office of the... transporting people. This section applies to all purchases or leases of new vehicles by private entities which are not primarily engaged in the business of transporting people, with respect to buses delivered to...

  18. 49 CFR 37.195 - Purchase or lease of OTRBs by private entities not primarily in the business of transporting people.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... primarily in the business of transporting people. 37.195 Section 37.195 Transportation Office of the... transporting people. This section applies to all purchases or leases of new vehicles by private entities which are not primarily engaged in the business of transporting people, with respect to buses delivered to...

  19. 49 CFR 37.195 - Purchase or lease of OTRBs by private entities not primarily in the business of transporting people.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... primarily in the business of transporting people. 37.195 Section 37.195 Transportation Office of the... transporting people. This section applies to all purchases or leases of new vehicles by private entities which are not primarily engaged in the business of transporting people, with respect to buses delivered to...

  20. 49 CFR 37.195 - Purchase or lease of OTRBs by private entities not primarily in the business of transporting people.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... primarily in the business of transporting people. 37.195 Section 37.195 Transportation Office of the... transporting people. This section applies to all purchases or leases of new vehicles by private entities which are not primarily engaged in the business of transporting people, with respect to buses delivered to...

  1. Using Coronal Hole Maps to Constrain MHD Models

    NASA Astrophysics Data System (ADS)

    Caplan, Ronald M.; Downs, Cooper; Linker, Jon A.; Mikic, Zoran

    2017-08-01

    In this presentation, we explore the use of coronal hole maps (CHMs) as a constraint for thermodynamic MHD models of the solar corona. Using our EUV2CHM software suite (predsci.com/chd), we construct CHMs from SDO/AIA 193Å and STEREO-A/EUVI 195Å images for multiple Carrington rotations leading up to the August 21st, 2017 total solar eclipse. We then contruct synoptic CHMs from synthetic EUV images generated from global thermodynamic MHD simulations of the corona for each rotation. Comparisons of apparent coronal hole boundaries and estimates of the net open flux are used to benchmark and constrain our MHD model leading up to the eclipse. Specifically, the comparisons are used to find optimal parameterizations of our wave turbulence dissipation (WTD) coronal heating model.

  2. Cross dimerization of amyloid-β and αsynuclein proteins in aqueous environment: a molecular dynamics simulations study.

    PubMed

    Jose, Jaya C; Chatterjee, Prathit; Sengupta, Neelanjana

    2014-01-01

    Self-assembly of the intrinsically unstructured proteins, amyloid beta (Aβ) and alpha synclein (αSyn), are associated with Alzheimer's Disease, and Parkinson's and Lewy Body Diseases, respectively. Importantly, pathological overlaps between these neurodegenerative diseases, and the possibilities of interactions between Aβ and αSyn in biological milieu emerge from several recent clinical reports and in vitro studies. Nevertheless, there are very few molecular level studies that have probed the nature of spontaneous interactions between these two sequentially dissimilar proteins and key characteristics of the resulting cross complexes. In this study, we have used atomistic molecular dynamics simulations to probe the possibility of cross dimerization between αSyn1-95 and Aβ1-42, and thereby gain insights into their plausible early assembly pathways in aqueous environment. Our analyses indicate a strong probability of association between the two sequences, with inter-protein attractive electrostatic interactions playing dominant roles. Principal component analysis revealed significant heterogeneity in the strength and nature of the associations in the key interaction modes. In most, the interactions of repeating Lys residues, mainly in the imperfect repeats 'KTKEGV' present in αSyn1-95 were found to be essential for cross interactions and formation of inter-protein salt bridges. Additionally, a hydrophobicity driven interaction mode devoid of salt bridges, where the non-amyloid component (NAC) region of αSyn1-95 came in contact with the hydrophobic core of Aβ1-42 was observed. The existence of such hetero complexes, and therefore hetero assembly pathways may lead to polymorphic aggregates with variations in pathological attributes. Our results provide a perspective on development of therapeutic strategies for preventing pathogenic interactions between these proteins.

  3. 49 CFR 195.303 - Risk-based alternative to pressure testing older hazardous liquid and carbon dioxide pipelines.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... criteria as an alternative to the pressure testing in § 195.302(b)(1)(i)-(iii) and § 195.302(b)(2)(i) of... in paragraph (b) of this section as follows: (1) Risk Classification A if the location indicator is ranked as low or medium risk, the product and volume indicators are ranked as low risk, and the...

  4. 49 CFR 195.303 - Risk-based alternative to pressure testing older hazardous liquid and carbon dioxide pipelines.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... criteria as an alternative to the pressure testing in § 195.302(b)(1)(i)-(iii) and § 195.302(b)(2)(i) of... in paragraph (b) of this section as follows: (1) Risk Classification A if the location indicator is ranked as low or medium risk, the product and volume indicators are ranked as low risk, and the...

  5. Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model

    PubMed Central

    Adamson Barnes, Nicholas S.; Mitchell, Vanessa A.; Kazantzis, Nicholas P.

    2015-01-01

    Background and Purpose While cannabinoids have been proposed as a potential treatment for neuropathic pain, they have limitations. Cannabinoid receptor agonists have good efficacy in animal models of neuropathic pain; they have a poor therapeutic window. Conversely, selective fatty acid amide hydrolase (FAAH) inhibitors that enhance the endocannabinoid system have a better therapeutic window, but lesser efficacy. We examined whether JZL195, a dual inhibitor of FAAH and monacylglycerol lipase (MAGL), could overcome these limitations. Experimental Approach C57BL/6 mice underwent the chronic constriction injury (CCI) model of neuropathic pain. Mechanical and cold allodynia, plus cannabinoid side effects, were assessed in response to systemic drug application. Key Results JZL195 and the cannabinoid receptor agonist WIN55212 produced dose‐dependent reductions in CCI‐induced mechanical and cold allodynia, plus side effects including motor incoordination, catalepsy and sedation. JZL195 reduced allodynia with an ED50 at least four times less than that at which it produced side effects. By contrast, WIN55212 reduced allodynia and produce side effects with similar ED50s. The maximal anti‐allodynic effect of JZL195 was greater than that produced by selective FAAH, or MAGL inhibitors. The JZL195‐induced anti‐allodynia was maintained during repeated treatment. Conclusions and Implications These findings suggest that JZL195 has greater anti‐allodynic efficacy than selective FAAH, or MAGL inhibitors, plus a greater therapeutic window than a cannabinoid receptor agonist. Thus, dual FAAH/MAGL inhibition may have greater potential in alleviating neuropathic pain, compared with selective FAAH and MAGL inhibitors, or cannabinoid receptor agonists. PMID:26398331

  6. Role of allosteric switch residue histidine 195 in maintaining active-site asymmetry in presynaptic filaments of bacteriophage T4 UvsX recombinase.

    PubMed

    Farb, Joshua N; Morrical, Scott W

    2009-01-16

    Recombinases of the highly conserved RecA/Rad51 family play central roles in homologous recombination and DNA double-stranded break repair. RecA/Rad51 enzymes form presynaptic filaments on single-stranded DNA (ssDNA) that are allosterically activated to catalyze ATPase and DNA strand-exchange reactions. Information is conveyed between DNA- and ATP-binding sites, in part, by a highly conserved glutamine residue (Gln194 in Escherichia coli RecA) that acts as an allosteric switch. The T4 UvsX protein is a divergent RecA ortholog and contains histidine (His195) in place of glutamine at the allosteric switch position. UvsX and RecA catalyze similar strand-exchange reactions, but differ in other properties. UvsX produces both ADP and AMP as products of its ssDNA-dependent ATPase activity--a property that is unique among characterized recombinases. Details of the kinetics of ssDNA-dependent ATP hydrolysis reactions indicate that UvsX-ssDNA presynaptic filaments are asymmetric and contain two classes of ATPase active sites: one that generates ADP, and another that generates AMP. Active-site asymmetry is reduced by mutations at the His195 position, since UvsX-H195Q and UvsX-H195A mutants both exhibit stronger ssDNA-dependent ATPase activity, with lower cooperativity and markedly higher ADP/AMP product ratios, than wild-type UvsX. Reduced active-site asymmetry correlates strongly with reduced ssDNA-binding affinity and DNA strand-exchange activity in both H195Q and H195A mutants. These and other results support a model in which allosteric switch residue His195 controls the formation of an asymmetric conformation of UvsX-ssDNA filaments that is active in DNA strand exchange. The implications of our findings for UvsX recombination functions, and for RecA functions in general, are discussed.

  7. 49 CFR 195.300 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.300 Scope. This subpart prescribes minimum requirements for the pressure...

  8. 49 CFR 195.300 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.300 Scope. This subpart prescribes minimum requirements for the pressure...

  9. 49 CFR 195.300 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.300 Scope. This subpart prescribes minimum requirements for the pressure...

  10. 49 CFR 195.300 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.300 Scope. This subpart prescribes minimum requirements for the pressure...

  11. 49 CFR 195.300 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.300 Scope. This subpart prescribes minimum requirements for the pressure...

  12. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016: A Systematic Analysis for the Global Burden of Disease Study.

    PubMed

    Fitzmaurice, Christina; Akinyemiju, Tomi F; Al Lami, Faris Hasan; Alam, Tahiya; Alizadeh-Navaei, Reza; Allen, Christine; Alsharif, Ubai; Alvis-Guzman, Nelson; Amini, Erfan; Anderson, Benjamin O; Aremu, Olatunde; Artaman, Al; Asgedom, Solomon Weldegebreal; Assadi, Reza; Atey, Tesfay Mehari; Avila-Burgos, Leticia; Awasthi, Ashish; Ba Saleem, Huda Omer; Barac, Aleksandra; Bennett, James R; Bensenor, Isabela M; Bhakta, Nickhill; Brenner, Hermann; Cahuana-Hurtado, Lucero; Castañeda-Orjuela, Carlos A; Catalá-López, Ferrán; Choi, Jee-Young Jasmine; Christopher, Devasahayam Jesudas; Chung, Sheng-Chia; Curado, Maria Paula; Dandona, Lalit; Dandona, Rakhi; das Neves, José; Dey, Subhojit; Dharmaratne, Samath D; Doku, David Teye; Driscoll, Tim R; Dubey, Manisha; Ebrahimi, Hedyeh; Edessa, Dumessa; El-Khatib, Ziad; Endries, Aman Yesuf; Fischer, Florian; Force, Lisa M; Foreman, Kyle J; Gebrehiwot, Solomon Weldemariam; Gopalani, Sameer Vali; Grosso, Giuseppe; Gupta, Rahul; Gyawali, Bishal; Hamadeh, Randah Ribhi; Hamidi, Samer; Harvey, James; Hassen, Hamid Yimam; Hay, Roderick J; Hay, Simon I; Heibati, Behzad; Hiluf, Molla Kahssay; Horita, Nobuyuki; Hosgood, H Dean; Ilesanmi, Olayinka S; Innos, Kaire; Islami, Farhad; Jakovljevic, Mihajlo B; Johnson, Sarah Charlotte; Jonas, Jost B; Kasaeian, Amir; Kassa, Tesfaye Dessale; Khader, Yousef Saleh; Khan, Ejaz Ahmad; Khan, Gulfaraz; Khang, Young-Ho; Khosravi, Mohammad Hossein; Khubchandani, Jagdish; Kopec, Jacek A; Kumar, G Anil; Kutz, Michael; Lad, Deepesh Pravinkumar; Lafranconi, Alessandra; Lan, Qing; Legesse, Yirga; Leigh, James; Linn, Shai; Lunevicius, Raimundas; Majeed, Azeem; Malekzadeh, Reza; Malta, Deborah Carvalho; Mantovani, Lorenzo G; McMahon, Brian J; Meier, Toni; Melaku, Yohannes Adama; Melku, Mulugeta; Memiah, Peter; Mendoza, Walter; Meretoja, Tuomo J; Mezgebe, Haftay Berhane; Miller, Ted R; Mohammed, Shafiu; Mokdad, Ali H; Moosazadeh, Mahmood; Moraga, Paula; Mousavi, Seyyed Meysam; Nangia, Vinay; Nguyen, Cuong Tat; Nong, Vuong Minh; Ogbo, Felix Akpojene; Olagunju, Andrew Toyin; Pa, Mahesh; Park, Eun-Kee; Patel, Tejas; Pereira, David M; Pishgar, Farhad; Postma, Maarten J; Pourmalek, Farshad; Qorbani, Mostafa; Rafay, Anwar; Rawaf, Salman; Rawaf, David Laith; Roshandel, Gholamreza; Safiri, Saeid; Salimzadeh, Hamideh; Sanabria, Juan Ramon; Santric Milicevic, Milena M; Sartorius, Benn; Satpathy, Maheswar; Sepanlou, Sadaf G; Shackelford, Katya Anne; Shaikh, Masood Ali; Sharif-Alhoseini, Mahdi; She, Jun; Shin, Min-Jeong; Shiue, Ivy; Shrime, Mark G; Sinke, Abiy Hiruye; Sisay, Mekonnen; Sligar, Amber; Sufiyan, Muawiyyah Babale; Sykes, Bryan L; Tabarés-Seisdedos, Rafael; Tessema, Gizachew Assefa; Topor-Madry, Roman; Tran, Tung Thanh; Tran, Bach Xuan; Ukwaja, Kingsley Nnanna; Vlassov, Vasiliy Victorovich; Vollset, Stein Emil; Weiderpass, Elisabete; Williams, Hywel C; Yimer, Nigus Bililign; Yonemoto, Naohiro; Younis, Mustafa Z; Murray, Christopher J L; Naghavi, Mohsen

    2018-06-02

    The increasing burden due to cancer and other noncommunicable diseases poses a threat to human development, which has resulted in global political commitments reflected in the Sustainable Development Goals as well as the World Health Organization (WHO) Global Action Plan on Non-Communicable Diseases. To determine if these commitments have resulted in improved cancer control, quantitative assessments of the cancer burden are required. To assess the burden for 29 cancer groups over time to provide a framework for policy discussion, resource allocation, and research focus. Cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs) were evaluated for 195 countries and territories by age and sex using the Global Burden of Disease study estimation methods. Levels and trends were analyzed over time, as well as by the Sociodemographic Index (SDI). Changes in incident cases were categorized by changes due to epidemiological vs demographic transition. In 2016, there were 17.2 million cancer cases worldwide and 8.9 million deaths. Cancer cases increased by 28% between 2006 and 2016. The smallest increase was seen in high SDI countries. Globally, population aging contributed 17%; population growth, 12%; and changes in age-specific rates, -1% to this change. The most common incident cancer globally for men was prostate cancer (1.4 million cases). The leading cause of cancer deaths and DALYs was tracheal, bronchus, and lung cancer (1.2 million deaths and 25.4 million DALYs). For women, the most common incident cancer and the leading cause of cancer deaths and DALYs was breast cancer (1.7 million incident cases, 535 000 deaths, and 14.9 million DALYs). In 2016, cancer caused 213.2 million DALYs globally for both sexes combined. Between 2006 and 2016, the average annual age-standardized incidence rates for all cancers combined increased in 130 of 195 countries or territories, and the average annual age-standardized death rates decreased within that timeframe in 143 of 195 countries or territories. Large disparities exist between countries in cancer incidence, deaths, and associated disability. Scaling up cancer prevention and ensuring universal access to cancer care are required for health equity and to fulfill the global commitments for noncommunicable disease and cancer control.

  13. Deep eutectic liquid organic salt as a new solvent for liquid-phase microextraction and its application in ligandless extraction and preconcentraion of lead and cadmium in edible oils.

    PubMed

    Karimi, Mehdi; Dadfarnia, Shayessteh; Shabani, Ali Mohammad Haji; Tamaddon, Fatemeh; Azadi, Davood

    2015-11-01

    Deep eutectic liquid organic salt was used as the solvent and a liquid phase microextraction (DES-LPME) combined with electrothermal atomic absorption spectrometry (ETAAS) was developed for separation, preconcentration and determination of lead and cadmium in edible oils. A 4:1 mixture of deep eutectic solvent and 2% nitric acid (200 µL) was added to an oil sample. The mixture was vortexed and transferred into a water bath at 50 °C and stirred for 5 minutes. After the extraction was completed, the phases were separated by centrifugation, and the enriched analytes in the deep eutectic solvent phase were determined by ETAAS. Under optimized extraction conditions and for an oil sample of 28 g, enhancement factors of 198 and 195 and limits of detection (defined as 3 Sb/m) of 8 and 0. 2 ng kg(-1) were achieved for lead and cadmium respectively. The method was successfully applied to the determination of lead and cadmium in various edible oils. Copyright © 2015. Published by Elsevier B.V.

  14. miR-195 inhibited abnormal activation of osteoblast differentiation in MC3T3-E1 cells via targeting RAF-1.

    PubMed

    Chao, Chen; Li, Feng; Tan, Zhiping; Zhang, Weizhi; Yang, Yifeng; Luo, Cheng

    2018-01-15

    Recent reports have demonstrated that RAF-1 L613V (a mutant of RAF-1) mutant mice show bone deformities similar to Noonan syndrome. It has been suggested that RAF-1 L613V might abnormally activate osteoblast differentiation of MC3T3-E1 cells. To demonstrate that RAF-1 is associated with bone deformity and that RAF-1 L613V dependent bone deformity could be inhibited by microRNA-195 (miR-195), we first investigated the amplifying influence of wild-type RAF-1 (WT) or RAF-1 L613V (L613V) on the viability and differentiation of MC3T3-E1 cells induced by bone morphogenetic protein-2 (BMP-2) via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, alkaline phosphatase (ALP) and Alizarin Red S (ARS) staining, quantitative real-time polymerase chain reaction (qRT-PCR) and western blot analysis. Subsequently, we investigated the blocking effect and its mechanism of miR-195 for abnormal activation of osteoblast differentiation of MC3T3-E1 cells via targeting RAF-1. RAF-1, especially RAF-1 L613V , abnormally activates osteoblast differentiation of MC3T3-E1 cells induced by BMP-2. Meanwhile, miR-195 could inhibit the cell viability and differentiation of MC3T3-E1 cells. Transfection of miR-195 largely suppressed the L613V-induced viability and osteoblast differentiation of MC3T3-E1 cells and attenuated the accelerative effect of L613V on runt-related transcription factor-2 (Runx2), Osterix (OSX), alkaline phosphatase (ALP), osteocalcin (OCN), and distal-less homeobox 5 (DLX5) osteogenic gene expressions. In addition, miR-195 decreased the expression of RAF-1 mRNA and protein by directly targeting the 3'-untranslated regions (3'-UTR) of RAF-1 mRNA in MC3T3-E1 cells. Our findings indicated that miR-195 inhibited WT and L613V RAF-1 induced hyperactive osteoblast differentiation in MC3T3-E1 cells by targeting RAF-1. miR-195 might be a novel therapeutic agent for the treatment of L613V-induced bone deformity in Noonan syndrome. Copyright © 2017. Published by Elsevier Inc.

  15. Preclinical imaging characteristics and quantification of Platinum-195m SPECT.

    PubMed

    Aalbersberg, E A; de Wit-van der Veen, B J; Zwaagstra, O; Codée-van der Schilden, K; Vegt, E; Vogel, Wouter V

    2017-08-01

    In vivo biodistribution imaging of platinum-based compounds may allow better patient selection for treatment with chemo(radio)therapy. Radiolabeling with Platinum-195m ( 195m Pt) allows SPECT imaging, without altering the chemical structure or biological activity of the compound. We have assessed the feasibility of 195m Pt SPECT imaging in mice, with the aim to determine the image quality and accuracy of quantification for current preclinical imaging equipment. Enriched (>96%) 194 Pt was irradiated in the High Flux Reactor (HFR) in Petten, The Netherlands (NRG). A 0.05 M HCl 195m Pt-solution with a specific activity of 33 MBq/mg was obtained. Image quality was assessed for the NanoSPECT/CT (Bioscan Inc., Washington DC, USA) and U-SPECT + /CT (MILabs BV, Utrecht, the Netherlands) scanners. A radioactivity-filled rod phantom (rod diameter 0.85-1.7 mm) filled with 1 MBq 195m Pt was scanned with different acquisition durations (10-120 min). Four healthy mice were injected intravenously with 3-4 MBq 195m Pt. Mouse images were acquired with the NanoSPECT for 120 min at 0, 2, 4, or 24 h after injection. Organs were delineated to quantify 195m Pt concentrations. Immediately after scanning, the mice were sacrificed, and the platinum concentration was determined in organs using a gamma counter and graphite furnace - atomic absorption spectroscopy (GF-AAS) as reference standards. A 30-min acquisition of the phantom provided visually adequate image quality for both scanners. The smallest visible rods were 0.95 mm in diameter on the NanoSPECT and 0.85 mm in diameter on the U-SPECT + . The image quality in mice was visually adequate. Uptake was seen in the kidneys with excretion to the bladder, and in the liver, blood, and intestine. No uptake was seen in the brain. The Spearman correlation between SPECT and gamma counter was 0.92, between SPECT and GF-AAS it was 0.84, and between GF-AAS and gamma counter it was0.97 (all p < 0.0001). Preclinical 195m Pt SPECT is feasible with acceptable tracer doses and acquisition times, and provides good image quality and accurate signal quantification.

  16. Elevated gamma-rays shielding property in lead-free bismuth tungstate by nanofabricating structures

    NASA Astrophysics Data System (ADS)

    Liu, Jun-Hua; Zhang, Quan-Ping; Sun, Nan; Zhao, Yang; Shi, Rui; Zhou, Yuan-Lin; Zheng, Jian

    2018-01-01

    Radiation shielding materials have attracted much attention across academia and industry because of the increasing of nuclear activities. To achieve the materials with low toxicity but good protective capability is one of the most significant goals for personal protective articles. Here, bismuth tungstate nanostructures are controllably fabricated by a versatile hydrothermal treatment under various temperatures. The crystals structure and morphology of products are detailedly characterized with X-ray diffraction, electron microscope and specific surface area. It is noteworthy that desired Bi2WO6 nanosheets treated with 190 °C show the higher specific surface area (19.5 m2g-1) than that of the other two products. Importantly, it has a close attenuating property to lead based counterpart for low energy gamma-rays. Due to the less toxicity, Bi2WO6 nanosheets are more suitable than lead based materials to fabricate personal protective articles for shielding low energy radiations and have great application prospect as well as market potential.

  17. Triple-element compound-specific stable isotope analysis of 1,2-dichloroethane for characterization of the underlying dehalogenation reaction in two Dehalococcoides mccartyi strains.

    PubMed

    Franke, Steffi; Lihl, Christina; Renpenning, Julian; Elsner, Martin; Nijenhuis, Ivonne

    2017-12-01

    Chlorinated ethanes belong to the most common groundwater and soil contaminants. Of these, 1,2-dichloroethane (1,2-DCA) is a man-made, persistent and toxic contaminant, released due to improper waste treatment at versatile production sites. This study investigated the anaerobic transformation of 1,2-DCA by Dehalococcoides mccartyi strain 195 and strain BTF08 using triple-element compound-specific stable isotope analysis of carbon, chlorine and hydrogen for the first time. Isotope fractionation patterns for carbon (εCBTF08 = -28.4 ± 3.7‰; εC195 = -30.9 ± 3.6‰) and chlorine (εClBTF08 = -4.6 ± 0.7‰; εCl195 = -4.2 ± 0.5‰) within both investigated D. mccartyi strains, as well as the dual-element analysis (ΛBTF08 = 6.9 ± 1.2; Λ195 = 7.1 ± 0.2), supported identical reaction mechanisms for dehalogenation of 1,2-DCA. Hydrogen isotope fractionation analysis revealed dihaloelimination as prevalent reaction mechanism. Vinyl chloride as major intermediate could be excluded by performing the experiment in deuterated aqueous media. Furthermore, evaluation of the derived apparent kinetic isotope effects (AKIECBTF08 = 1.029/AKIEC195 = 1.031; AKIEClBTF08 = 1.005/AKIECl195 = 1.004) pointed towards simultaneous abstraction of both involved chlorine-substituents in a concerted matter. It was shown that D. mccartyi strain BTF08 and strain 195 are capable of complete, direct dihaloelimination of 1,2-DCA to ethene. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  18. microRNAs regulate nitric oxide release from endothelial cells by targeting NOS3.

    PubMed

    Qin, Ji-Zheng; Wang, Shao-Jie; Xia, Chun

    2018-06-13

    Endothelial nitric oxide synthase (eNOS) encoded by nitric oxide synthase 3 (NOS3), can generate nitric oxide (NO) which serves as an important deterrent to the pathogenesis of thrombosis by modulating the activation, adhesion and aggregate formation of platelets. Three serum miRNAs (miR-195, miR-532 and miR-582) have been suggested as biomarkers for the diagnosis of deep vein thrombosis (DVT), however their potential roles in DVT is not clear. The effect of miRNAs inhibiting the expression of NOS3 was evaluated in vitro. miR-195, miR-532 and miR-582 mimic, inhibitor, and control miRNAs were transfected into endothelial cells. The roles of miR-195, miR-532 and miR-582 regulating the expression of eNOS were evaluated by real-time quantitative PCR, Western Blotting and luciferase reporter assays. NO release was measured by Griess method. We confirmed NOS3 as a direct target of miR-195 and miR-582, which binds to the 3'-UTR of NOS3 mRNA in endothelial cells. A significantly inverse correlation between these two miRNAs and eNOS expression was detected. NO release from endothelial cells was decreased when the expression level of miR-195 and miR-582 was up-regulated. These findings indicated that miR-195 and miR-582 regulated NO release by targeting 3'-UTR of NOS3 post-transcriptionally in endothelial cells. Therefore, miR-195 and miR-582 might play an important role in maintaining endothelial NO bioavailability and could be a novel target for treatment of thrombotic diseases.

  19. Parameters for the Operation of Bacterial Thiosalt Oxidation Ponds

    PubMed Central

    Silver, M.

    1985-01-01

    Shake flask and pH-controlled reactor tests were used to determine the mathematical parameters for a mixed-culture bacterial thiosalt treatment pond. Values determined were as follows: Km and Vmax (thiosulfate), 9.83 g/liter and 243.9 mg/liter per h, respectively; Ki (lead), 3.17 mg/liter; Ki (copper), 1.27 mg/liter; Q10 between 10 and 30°C, 1.95. From these parameters, the required bioxidation pond volume and residence time could be calculated. Soluble zinc (0.2 g/liter) and particulate mill products and by-products (0.25 g/liter) were not inhibitory. Correlation with an operating thiosalt biooxidation pond showed the parameters used to be valid for thiosalt concentrations up to at least 2 g/liter, lead concentrations of at least 10 mg/liter, and temperatures of >2°C. PMID:16346885

  20. 27 CFR 1.95 - General.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... industrial use, unless such distilled spirits are shipped or delivered directly to the industrial user... of Distilled Spirits Sales of Distilled Spirits for Industrial Use § 1.95 General. Distillers...

  1. Infectious diseases publications in leading medical journals--a comparative analysis.

    PubMed

    Fätkenheuer, G; Roer, F; Hirschel, B; Cornely, O A; Salzberger, B

    2012-10-01

    The representation of medical disciplines in leading journals may provide valuable information on their respective importance for both researchers and funding agencies. We were interested in the scientific contribution of infectious diseases to leading medical journals and their ranking compared to other medical disciplines. Original articles and short communications in three leading medical journals from 2003 to 2009 were analyzed by contributing medical discipline and by nation: The New England Journal of Medicine (NEJM), The Lancet, and the Journal of the American Medical Association (JAMA). The medical disciplines were selected according to a standard textbook (Harrison's Principles of Internal Medicine). Each article was categorized into one to three medical disciplines. The most frequently represented disciplines in 3,953 articles were cardiology (19.5 %), infectious diseases (18.6 %), and hematology/oncology (15.9 %). Each of the journals had another leading discipline: cardiology in JAMA, hematology/oncology in NEJM, and infectious diseases in The Lancet. In the American journals, contributions from US researchers dominated the field (52.6 % in NEJM, 73.6 % in JAMA), while the majority of papers in The Lancet originated from non-US residents (76.5 %). This study underlines the importance of infectious diseases as a medical discipline in clinical research.

  2. 1. View of bridge from Interstate 195 (Washington Bridge) looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. View of bridge from Interstate 195 (Washington Bridge) looking southwest - India Point Railroad Bridge, Spanning Seekonk River between Providence & East Providence, Providence, Providence County, RI

  3. Synthesis and magnetostrictive properties of Pr(Fe1.95B0.05)1.93 bulk nanocrystalline alloy

    NASA Astrophysics Data System (ADS)

    Shi, Y. G.; Hu, C. C.; Fan, J. Y.; Shi, D. N.; Lv, L. Y.; Tang, S. L.

    2012-11-01

    The structure, magnetic properties, and magnetostriction of Pr(Fe1.95B0.05)1.93 alloys prepared by annealing its precursor amorphous ribbons under high pressure were investigated. It was found that Pr(Fe1.95B0.05)1.93 single cubic Laves phase could be obtained only when the pressure is up to 3 GPa. The average grain size about 20 nm is found in the sample synthesized under 6 GPa. A large linear magnetostriction of 541 ppm at 3 kOe is observed in the Pr(Fe1.95B0.05)1.93 compound synthesized under 6 GPa, which is 25% larger than that under 3 GPa. The present work offers an effective method to obtain bulk nanocrystalline magnetostrictive compounds.

  4. 49 CFR 195.308 - Testing of tie-ins.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.308 Testing of tie-ins. Pipe associated with tie-ins must be pressure...

  5. 49 CFR 195.308 - Testing of tie-ins.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.308 Testing of tie-ins. Pipe associated with tie-ins must be pressure...

  6. 49 CFR 195.308 - Testing of tie-ins.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.308 Testing of tie-ins. Pipe associated with tie-ins must be pressure...

  7. 49 CFR 195.308 - Testing of tie-ins.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.308 Testing of tie-ins. Pipe associated with tie-ins must be pressure...

  8. 49 CFR 195.308 - Testing of tie-ins.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.308 Testing of tie-ins. Pipe associated with tie-ins must be pressure...

  9. 40 CFR 195.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROFICIENCY PROGRAMS General Provisions § 195.2 Definitions. Definitions in 15 U.S.C. 2602 and 2662 apply to... exam means the exam which evaluates individuals who provide radon measurement services in a residential...

  10. 49 CFR 195.116 - Valves.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PIPELINE Design Requirements § 195.116 Valves. Each valve installed in a pipeline system must comply with the following: (a) The valve must be of a sound engineering design. (b) Materials subject to the...

  11. 30 CFR 19.5 - General requirements for approval.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., AND APPROVAL OF MINING PRODUCTS ELECTRIC CAP LAMPS § 19.5 General requirements for approval. Electric cap lamps shall be complete units. They shall be durable in construction, practical in operation, and...

  12. 46 CFR 195.35-5 - General.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 1014 (incorporated by reference, see § 195.01-3). (d) All lifelines shall be of steel or bronze wire rope. Steel wire rope shall be either inherently corrosion-resistant, or made so by galvanizing or...

  13. 46 CFR 195.35-5 - General.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 1014 (incorporated by reference, see § 195.01-3). (d) All lifelines shall be of steel or bronze wire rope. Steel wire rope shall be either inherently corrosion-resistant, or made so by galvanizing or...

  14. Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2.

    PubMed

    Yun, Bogeon; Lee, HeeJung; Powell, Roger; Reisdorph, Nichole; Ewing, Heather; Gelb, Michael H; Hsu, Ku-Lung; Cravatt, Benjamin F; Leslie, Christina C

    2017-09-02

    The serine hydrolase inhibitors pyrrophenone and KT195 inhibit cell death induced by A23187 and H 2 O 2 by blocking the release of calcium from the endoplasmic reticulum and mitochondrial calcium uptake. The effect of pyrrophenone and KT195 on these processes is not due to inhibition of their known targets, cytosolic phospholipase A 2 and α/β-hydrolase domain-containing (ABHD) 6, respectively, but represent off-target effects. To identify targets of KT195, fibroblasts were treated with KT195-alkyne to covalently label protein targets followed by click chemistry with biotin azide, enrichment on streptavidin beads and tryptic peptide analysis by mass spectrometry. Although several serine hydrolases were identified, α/β-hydrolase domain-containing 2 (ABHD2) was the only target in which both KT195 and pyrrophenone competed for binding to KT195-alkyne. ABHD2 is a serine hydrolase with a predicted transmembrane domain consistent with its pull-down from the membrane proteome. Subcellular fractionation showed localization of ABHD2 to the endoplasmic reticulum but not to mitochondria or mitochondrial-associated membranes. Knockdown of ABHD2 with shRNA attenuated calcium release from the endoplasmic reticulum, mitochondrial calcium uptake and cell death in fibroblasts stimulated with A23187. The results describe a novel mechanism for regulating calcium transfer from the endoplasmic reticulum to mitochondria that involves the serine hydrolase ABHD2. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. 49 CFR 195.266 - Construction records.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... rejected weld. (b) The amount, location; and cover of each size of pipe installed. (c) The location of each... overhead crossing. (f) The location of each valve and corrosion test station. [Amdt. 195-22, 46 FR 38360...

  16. The crystal structure of red fluorescent protein TagRFP-T reveals the mechanism of its superior photostability

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, Rui; Liang, Qing-Nan; Du, Shu-Qi

    2016-08-19

    The red fluorescent protein variant TagRFP-T has greatly improved photostability over its parent molecule, TagRFP, but the underlying mechanism leading to this improvement is to date unknown. The 1.95 Å resolution crystallographic structure of TagRFP-T showed that its chromophore exists as a mixture of cis and trans coplanar isomers in roughly equal proportions. Interestingly, both isomers are able to fluoresce, a property that has never been observed in any other fluorescent protein. We propose a “circular restoration model” for TagRFP-T to explain its superior photostability: There are four co-existing chromophore states (cis/trans protonated/ionized state) that can be driven by light tomore » transform from one state into another. This model also explains how TagRPF-T essentially eliminates the temporary dark state (reversible photobleaching). - Highlights: • The 1.95 Å resolution crystal structure of TagRFP-T was determined. • The chromophore of TagRFP-T contains a mixture of cis and trans coplanar isomers. • A “circular restoration model” was proposed to explain the superior photostability. • The chromophore can reversibly convert between cis/trans protonated/ionized states. • The light-driven conversion reduce the dark state (reversible photobleaching).« less

  17. Structure of the C-terminal effector-binding domain of AhrC bound to its corepressor l-arginine

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Garnett, James A.; Baumberg, Simon; Stockley, Peter G.

    2007-11-01

    The crystal structure of the C-terminal domain hexameric core of AhrC, with bound corepressor (l-arginine), has been solved at 1.95 Å resolution. Binding of l-arginine results in a rotation between the two trimers of the hexamer, leading to the activation of the DNA-binding state. The arginine repressor/activator protein (AhrC) from Bacillus subtilis belongs to a large family of multifunctional transcription factors that are involved in the regulation of bacterial arginine metabolism. AhrC interacts with operator sites in the promoters of arginine biosynthetic and catabolic operons, acting as a transcriptional repressor at biosynthetic sites and an activator of transcription at catabolicmore » sites. AhrC is a hexamer of identical subunits, each having two domains. The C-terminal domains form the core of the protein and are involved in oligomerization and l-arginine binding. The N-terminal domains lie on the outside of the compact core and play a role in binding to 18 bp DNA operators called ARG boxes. The C-terminal domain of AhrC has been expressed, purified and characterized, and also crystallized as a hexamer with the bound corepressor l-arginine. Here, the crystal structure refined to 1.95 Å is presented.« less

  18. Human fatalities from cyanobacteria: chemical and biological evidence for cyanotoxins.

    PubMed Central

    Carmichael, W W; Azevedo, S M; An, J S; Molica, R J; Jochimsen, E M; Lau, S; Rinehart, K L; Shaw, G R; Eaglesham, G K

    2001-01-01

    An outbreak of acute liver failure occurred at a dialysis center in Caruaru, Brazil (8 degrees 17' S, 35 degrees 58' W), 134 km from Recife, the state capital of Pernambuco. At the clinic, 116 (89%) of 131 patients experienced visual disturbances, nausea, and vomiting after routine hemodialysis treatment on 13-20 February 1996. Subsequently, 100 patients developed acute liver failure, and of these 76 died. As of December 1996, 52 of the deaths could be attributed to a common syndrome now called Caruaru syndrome. Examination of phytoplankton from the dialysis clinic's water source, analyses of the clinic's water treatment system, plus serum and liver tissue of clinic patients led to the identification of two groups of cyanobacterial toxins, the hepatotoxic cyclic peptide microcystins and the hepatotoxic alkaloid cylindrospermopsin. Comparison of victims' symptoms and pathology using animal studies of these two cyanotoxins leads us to conclude that the major contributing factor to death of the dialyses patients was intravenous exposure to microcystins, specifically microcystin-YR, -LR, and -AR. From liver concentrations and exposure volumes, it was estimated that 19.5 microg/L microcystin was in the water used for dialysis treatments. This is 19.5 times the level set as a guideline for safe drinking water supplies by the World Health Organization. PMID:11485863

  19. Ecology of Harmful Algae

    NASA Astrophysics Data System (ADS)

    Roelke, Daniel L.

    2007-07-01

    Edna Graneli and Jefferson T. Turner, Editors;Ecological Studies Series, Vol. 189; Springer; ISBN 3540322094; 413 pp.; 2006; $195 Harmful algal blooms (HABs) affect commercially and recreationally important species, human health, and ecosystem functioning. Hallmark events are the visually stunning blooms where waters are discolored and filled with ichthyotoxin-producing algae that lead to large fish kills. Of most concern, however, are HABs that pose a threat to human health. For example, some phycotoxins bioaccumulate in the guts and tissues of commercially and recreationally important species that when consumed by humans, may result in nausea, paralysis, memory loss, and even death. In addition to the deleterious impacts of phycotoxins, HABs can be problematic in other ways. For example, the decay of blooms often leads to low dissolved oxygen in subsurface waters. Blooms also reduce light penetration into the water column. Both processes disrupt ecosystems and in some cases have completely destroyed benthic communities.

  20. Lead-Free, Two-Dimensional Mixed Germanium and Tin Perovskites.

    PubMed

    Cheng, Pengfei; Wu, Tao; Liu, Junxue; Deng, Wei-Qiao; Han, Keli

    2018-05-17

    Hybrid two-dimensional (2D) organic-inorganic perovskites continue to draw increased attention in view of their outstanding performance in optoelectronic devices such as solar cells and light-emitting devices. Herein, for the first time, we report the synthesis and characterization of lead-free, 2D mixed Ge-Sn halide perovskites, (PEA) 2 Ge 1- x Sn x I 4 (where PEA = C 6 H 5 CH 2 CH 2 NH 3 + ), and demonstrate that the bandgaps decrease linearly with increasing Sn content. Most importantly, among them, (PEA) 2 Ge 0.5 Sn 0.5 I 4 possesses the smallest bandgap of 1.95 eV. Density functional theory calculations confirm that Sn substitution induces a smaller bandgap and more dispersed band structure, which are desirable characteristics of light-absorbing materials. In addition, conductivity and stability of (PEA) 2 Ge 0.5 Sn 0.5 I 4 have also been assessed.

  1. 49 CFR 195.55 - Reporting safety-related conditions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... hazardous liquid could reasonably be expected to pollute any stream, river, lake, reservoir, or other body of water; (2) Is an accident that is required to be reported under § 195.50 or results in such an...

  2. 49 CFR 195.55 - Reporting safety-related conditions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... hazardous liquid could reasonably be expected to pollute any stream, river, lake, reservoir, or other body of water; (2) Is an accident that is required to be reported under § 195.50 or results in such an...

  3. 21 CFR 1271.195 - Environmental control and monitoring.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... of, environmental control and monitoring activities. ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Environmental control and monitoring. 1271.195... control and monitoring. (a) Environmental control. Where environmental conditions could reasonably be...

  4. 21 CFR 1271.195 - Environmental control and monitoring.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... of, environmental control and monitoring activities. ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Environmental control and monitoring. 1271.195... control and monitoring. (a) Environmental control. Where environmental conditions could reasonably be...

  5. 21 CFR 1271.195 - Environmental control and monitoring.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of, environmental control and monitoring activities. ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Environmental control and monitoring. 1271.195... control and monitoring. (a) Environmental control. Where environmental conditions could reasonably be...

  6. 21 CFR 1271.195 - Environmental control and monitoring.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... of, environmental control and monitoring activities. ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Environmental control and monitoring. 1271.195... control and monitoring. (a) Environmental control. Where environmental conditions could reasonably be...

  7. X-45A in flight with F-18 #846 chase aircraft, during first GPS-guided weapon demonstration flight

    NASA Image and Video Library

    2002-12-19

    The first X-45A Unmanned Combat Air Vehicle (UCAV) technology demonstrator completed its sixth flight on Dec. 19, 2002, raising its landing gear in flight for the first time. The X-45A flew for 40 minutes and reached an airspeed of 195 knots and an altitude of 7,500 feet. Dryden is supporting the DARPA/Boeing team in the design, development, integration, and demonstration of the critical technologies, processes, and system attributes leading to an operational UCAV system. Dryden support of the X-45A demonstrator system includes analysis, component development, simulations, ground and flight tests.

  8. Characterization of Emissions Produced by the Open Burning/Open Detonation of Complex Munitions

    DTIC Science & Technology

    1996-09-01

    Picoline I ,4-Naphthoquinone N-Nitrosomethylethylamnine 1.3 -Dinitrobenzene Methyl methanesulfonate Pentachi orobenzene N-Nitrosodi ethyl amine 1... Chromium Zinc Copper 3.2.6 Particulate Matter Less Than Ten Microns in Diameter (PM10) 3.2.7 Dioxins and Furans The analysis for dioxins and furans...6.24e-04 2.09e-03 Chromium 5.69e-06 4.19e-06 3.2 1e-06 4.36e-06 1.25e-06 -5.06e-06 Copper 1.74e-04 1.03e-04 7.16e-05 1. 16e-04 5.23e-05 1.95e-04 Lead

  9. Comparison of measured and computed pitot pressures in a leading edge vortex from a delta wing

    NASA Technical Reports Server (NTRS)

    Murman, Earll M.; Powell, Kenneth G.

    1987-01-01

    Calculations are presented for a 75-deg swept flat plate wing tested at a freestream Mach number of 1.95 and 10 degrees angle of attack. Good agreement is found between computational data and previous experimental pitot pressure measurements in the core of the vortex, suggesting that the total pressure losses predicted by the Euler equation solvers are not errors, but realistic predictions. Data suggest that the magnitude of the total pressure loss is related to the circumferential velocity field through the vortex, and that it increases with angle of attack and varies with Mach number and sweep angle.

  10. 49 CFR 195.134 - CPM leak detection.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... system must comply with section 4.2 of API 1130 in its design and with any other design criteria addressed in API 1130 for components of the CPM leak detection system. [Amdt. 195-62, 63 FR 36376, July 6...

  11. 49 CFR 195.134 - CPM leak detection.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... system must comply with section 4.2 of API 1130 in its design and with any other design criteria addressed in API 1130 for components of the CPM leak detection system. [Amdt. 195-62, 63 FR 36376, July 6...

  12. 49 CFR 195.134 - CPM leak detection.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... system must comply with section 4.2 of API 1130 in its design and with any other design criteria addressed in API 1130 for components of the CPM leak detection system. [Amdt. 195-62, 63 FR 36376, July 6...

  13. 49 CFR 195.134 - CPM leak detection.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... system must comply with section 4.2 of API 1130 in its design and with any other design criteria addressed in API 1130 for components of the CPM leak detection system. [Amdt. 195-62, 63 FR 36376, July 6...

  14. 49 CFR 195.134 - CPM leak detection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... system must comply with section 4.2 of API 1130 in its design and with any other design criteria addressed in API 1130 for components of the CPM leak detection system. [Amdt. 195-62, 63 FR 36376, July 6...

  15. HSF1 deficiency accelerates the transition from pressure overload-induced cardiac hypertrophy to heart failure through endothelial miR-195a-3p-mediated impairment of cardiac angiogenesis.

    PubMed

    Wang, Shijun; Wu, Jian; You, Jieyun; Shi, Hongyu; Xue, Xiaoyu; Huang, Jiayuan; Xu, Lei; Jiang, Guoliang; Yuan, Lingyan; Gong, Xue; Luo, Haiyan; Ge, Junbo; Cui, Zhaoqiang; Zou, Yunzeng

    2018-05-01

    Heat shock transcription factor 1 (HSF1) deficiency aggravates cardiac remodeling under pressure overload. However, the mechanism is still unknown. Here we employed microRNA array analysis of the heart tissue of HSF1-knockout (KO) mice to investigate the potential roles of microRNAs in pressure overload-induced cardiac remodeling under HSF-1 deficiency, and the profiles of 478 microRNAs expressed in the heart tissues of adult HSF1-KO mice were determined. We found that the expression of 5 microRNAs was over 2-fold higher expressed in heart tissues of HSF1-KO mice than in those of wild-type (WT) control mice. Of the overexpressed microRNAs, miR-195a-3p had the highest expression level in HSF1-null endothelial cells (ECs). Induction with miR-195a-3p in ECs significantly suppressed CD31 and VEGF, promoted AngII-induced EC apoptosis, and impaired capillary-like tube formation. In vivo, the upregulation of miR-195a-3p accentuated cardiac hypertrophy, increased the expression of β-MHC and ANP, and compromised systolic function in mice under pressure overload induced by transverse aortic constriction (TAC). By contrast, antagonism of miR-195a-3p had the opposite effect on HSF1-KO mice. Further experiments confirmed that AMPKα2 was the direct target of miR-195a-3p. AMPKα2 overexpression rescued the reduction of eNOS and VEGF, and the impairment of angiogenesis that was induced by miR-195a-3p. In addition, upregulation of AMPKα2 in the myocardium of HSF1-null mice by adenovirus-mediated gene delivery enhanced CD31, eNOS and VEGF, reduced β-MHC and ANP, alleviated pressure overload-mediated cardiac hypertrophy and restored cardiac function. Our findings revealed that the upregulation of miR-195a-3p due to HSF1 deficiency impaired cardiac angiogenesis by regulating AMPKα2/VEGF signaling, which disrupted the coordination between the myocardial blood supply and the adaptive hypertrophic response and accelerated the transition from cardiac hypertrophy to heart failure in response to pressure overload. Copyright © 2018 Elsevier Ltd. All rights reserved.

  16. Heavy metal hazards of sachet water in Nigeria.

    PubMed

    Orisakwe, Orish Ebere; Igwilo, Innocent O; Afonne, Onyenmechi Johnson; Maduabuchi, John-Moses Ugwuona; Obi, Ejeatuluchukwu; Nduka, John C

    2006-01-01

    The authors assessed sachet water samples sold in Eastern Nigeria. Using an atomic absorption spectrophotometer, they analyzed levels of lead, cadmium, copper, and nickel. They also analyzed other parameters, such as nitrates, sulfates, chlorides, salinity, total hardness, biological oxygen demand, total dissolved solids, and pH level. Lead levels ranged from 0.002 to 0.036 mg/L in the samples; 5 samples (12.2%) had lead levels above the maximum contaminant level (MCL; 0.015 mg/L). Lead was not detectable in 20 samples (48.8%). Cadmium levels ranged from 0.002 to 0.036 mg/L and exceeded the MCL of 0.005 mg/L in 8 samples (19.5%); it was not detectable in 23 samples (56.1%). Copper was not detected in 2 (0.05%) of the samples. Its range was between 0.018 and 1.401 mg/L. Two samples (0.05%) had copper levels above the MCL (1.30 mg/L). Nickel levels ranged from 0.003 to 0.050 mg/l. The biological oxygen demand of the samples ranged from 3.20 to 36.80 mg/L. Other parameters were normal. The authors found that some of the sachet waters contain heavy metals, and consumers may be exposed to hazards.

  17. 40 CFR 195.1 - Purpose and applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROGRAMS RADON PROFICIENCY PROGRAMS General Provisions § 195.1 Purpose and applicability. (a) Purpose. The... following programs: The National Radon Measurement Proficiency (RMP) Program, the individual proficiency component of the RMP Program, and the National Radon Contractor Proficiency (RCP) Program. (b) Applicability...

  18. 49 CFR 195.302 - General requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... without pressure testing under this subpart: (1) Any hazardous liquid pipeline whose maximum operating... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.302 General requirements. (a) Except as otherwise provided in this section...

  19. 49 CFR 195.302 - General requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... without pressure testing under this subpart: (1) Any hazardous liquid pipeline whose maximum operating... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.302 General requirements. (a) Except as otherwise provided in this section...

  20. 49 CFR 195.302 - General requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... without pressure testing under this subpart: (1) Any hazardous liquid pipeline whose maximum operating... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.302 General requirements. (a) Except as otherwise provided in this section...

  1. 49 CFR 195.302 - General requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... without pressure testing under this subpart: (1) Any hazardous liquid pipeline whose maximum operating... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.302 General requirements. (a) Except as otherwise provided in this section...

  2. 49 CFR 195.302 - General requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... without pressure testing under this subpart: (1) Any hazardous liquid pipeline whose maximum operating... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.302 General requirements. (a) Except as otherwise provided in this section...

  3. 40 CFR 195.1 - Purpose and applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PROGRAMS RADON PROFICIENCY PROGRAMS General Provisions § 195.1 Purpose and applicability. (a) Purpose. The... following programs: The National Radon Measurement Proficiency (RMP) Program, the individual proficiency component of the RMP Program, and the National Radon Contractor Proficiency (RCP) Program. (b) Applicability...

  4. 49 CFR 195.575 - Which facilities must I electrically isolate and what inspections, tests, and safeguards are...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Corrosion Control § 195.575 Which facilities must I electrically isolate and what inspections, tests, and... isolation of a portion of a pipeline is necessary to facilitate the application of corrosion control. (c...

  5. 49 CFR 195.440 - Public awareness.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Petroleum Institute's (API) Recommended Practice (RP) 1162 (incorporated by reference, see § 195.3). (b) The operator's program must follow the general program recommendations of API RP 1162 and assess the unique... general program recommendations, including baseline and supplemental requirements of API RP 1162, unless...

  6. 49 CFR 195.440 - Public awareness.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Petroleum Institute's (API) Recommended Practice (RP) 1162 (incorporated by reference, see § 195.3). (b) The operator's program must follow the general program recommendations of API RP 1162 and assess the unique... general program recommendations, including baseline and supplemental requirements of API RP 1162, unless...

  7. 49 CFR 195.440 - Public awareness.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Petroleum Institute's (API) Recommended Practice (RP) 1162 (incorporated by reference, see § 195.3). (b) The operator's program must follow the general program recommendations of API RP 1162 and assess the unique... general program recommendations, including baseline and supplemental requirements of API RP 1162, unless...

  8. Malaria prevalence defined by microscopy, antigen detection, DNA amplification and total nucleic acid amplification in a malaria-endemic region during the peak malaria transmission season.

    PubMed

    Waitumbi, John N; Gerlach, Jay; Afonina, Irina; Anyona, Samuel B; Koros, Joseph N; Siangla, Joram; Ankoudinova, Irina; Singhal, Mitra; Watts, Kate; Polhemus, Mark E; Vermeulen, Nicolaas M; Mahoney, Walt; Steele, Matt; Domingo, Gonzalo J

    2011-07-01

    To determine the malaria prevalence by microscopy, antigen detection and nucleic acid detection in a defined subpopulation in a Plasmodium falciparum-endemic region during the peak transmission season. Blood specimens were collected in a cross-sectional study involving children aged 5-10 years (n = 195) presenting with acute fever to two clinics in Western Kenya. All specimens underwent microscopy, HRP2 and aldolase antigen detection by enzyme immunoassay (EIA), parasite-specific DNA and total nucleic acid (RNA and DNA) by real-time PCR (qPCR) and reverse-transcriptase PCR (qRT-PCR). Microscopy detected 65/195 cases of malaria infection [95% confidence interval (CI) 52-78]. HRP2 and aldolase EIA had similar sensitivity levels detecting antigen in 65/195 (95% CI, 52-78) and 57/195 (95% CI, 45-70) cases. Discordants in antigen detection vs. microscopy occurred at <470 parasites/μl and <4900 parasites/μl for HRP2 and aldolase, respectively. Detection of total nucleic acid allowed a 3 log lower limit of detection than just DNA detection by real-time PCR in vitro. In clinical specimens, 114/195 (95% CI, 100-127) were qPCR positive (DNA), and 187/195 (95% CI, 179-191) were qRT-PCR positive (DNA plus RNA). The prevalence of submicroscopic malaria infection was significantly higher when detecting total nucleic acid than just DNA in this outpatient population during the high transmission season. Defining standards for submicroscopic infection will be important for control programmes, diagnostics development efforts and molecular epidemiology studies. © 2011 Blackwell Publishing Ltd.

  9. 14 CFR 221.195 - Requirement for filing printed material.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS Electronically Filed Tariffs § 221.195 Requirement for filing printed material. (a) Any tariff, or revision thereto, filed in paper format which accompanies....190(b). Further, such paper tariff, or revision thereto, shall be filed in accordance with the...

  10. Field study of the air quality impact of Route I-195 at Richmond, Virginia.

    DOT National Transportation Integrated Search

    1982-01-01

    This investigation attempted to assess the mesoscale and microscale effects of the recently built Interstate Route I-195 in Richmond, Virginia. Measurement of the air quality before and after completion of the expressway showed that on the mesoscale,...

  11. 49 CFR 195.57 - Filing offshore pipeline condition reports.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Annual, Accident, and Safety-Related Condition Reporting § 195.57... information: (1) Name and principal address of operator. (2) Date of report. (3) Name, job title, and business...

  12. 49 CFR 195.588 - What standards apply to direct assessment?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.588 What standards apply to direct... corrosion, you must follow the requirements of this section for performing external corrosion direct... direct assessment process. (b) The requirements for performing external corrosion direct assessment are...

  13. 14 CFR 121.195 - Airplanes: Turbine engine powered: Landing limitations: Destination airports.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Airplanes: Turbine engine powered: Landing...: CERTIFICATION AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Airplane Performance Operating Limitations § 121.195 Airplanes: Turbine engine powered: Landing limitations...

  14. 14 CFR 121.195 - Airplanes: Turbine engine powered: Landing limitations: Destination airports.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Airplanes: Turbine engine powered: Landing...: CERTIFICATION AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Airplane Performance Operating Limitations § 121.195 Airplanes: Turbine engine powered: Landing limitations...

  15. 14 CFR 121.195 - Airplanes: Turbine engine powered: Landing limitations: Destination airports.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Airplanes: Turbine engine powered: Landing...: CERTIFICATION AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Airplane Performance Operating Limitations § 121.195 Airplanes: Turbine engine powered: Landing limitations...

  16. 49 CFR 195.310 - Records.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.310 Records. (a) A record must be made of each pressure test required by... use. (b) The record required by paragraph (a) of this section must include: (1) The pressure recording...

  17. 49 CFR 195.310 - Records.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.310 Records. (a) A record must be made of each pressure test required by... use. (b) The record required by paragraph (a) of this section must include: (1) The pressure recording...

  18. 49 CFR 195.588 - What standards apply to direct assessment?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.588 What standards apply to direct... corrosion, you must follow the requirements of this section for performing external corrosion direct... direct assessment process. (b) The requirements for performing external corrosion direct assessment are...

  19. 49 CFR 195.588 - What standards apply to direct assessment?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.588 What standards apply to direct... corrosion, you must follow the requirements of this section for performing external corrosion direct... direct assessment process. (b) The requirements for performing external corrosion direct assessment are...

  20. 49 CFR 195.588 - What standards apply to direct assessment?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.588 What standards apply to direct... corrosion, you must follow the requirements of this section for performing external corrosion direct... direct assessment process. (b) The requirements for performing external corrosion direct assessment are...

  1. 12 CFR 195.27 - Strategic plan.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Assessing Performance § 195.27 Strategic plan. (a) Alternative election. The appropriate Federal banking... under an approved plan for at least one year. (b) Data reporting. The appropriate Federal banking agency... any multi-year plan must include annual interim measurable goals under which the appropriate Federal...

  2. 12 CFR 195.27 - Strategic plan.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Assessing Performance § 195.27 Strategic plan. (a) Alternative election. The appropriate Federal banking... under an approved plan for at least one year. (b) Data reporting. The appropriate Federal banking agency... any multi-year plan must include annual interim measurable goals under which the appropriate Federal...

  3. 12 CFR 195.27 - Strategic plan.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Assessing Performance § 195.27 Strategic plan. (a) Alternative election. The appropriate Federal banking... under an approved plan for at least one year. (b) Data reporting. The appropriate Federal banking agency... any multi-year plan must include annual interim measurable goals under which the appropriate Federal...

  4. 21 CFR 58.195 - Retention of records.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Records and Reports § 58.195 Retention of records. (a..., documentation records, raw data and specimens pertaining to a nonclinical laboratory study and required to be...

  5. Acetylene fuels reductive dechlorination of TCE by Dehalococcoides/Pelobacter-containing microbial consortia

    NASA Astrophysics Data System (ADS)

    Oremland, R. S.; Mao, X.; Mahandra, C.; Baesman, S. M.; Gushgari, S.; Alvarez-Cohen, L.; Liu, T.

    2015-12-01

    Groundwater contamination by trichloroethene (TCE) poses a threat to health and leads to the generation of vinyl chloride (VC), a carcinogen. Dehalococcoides mccartyi is the only bacterium that can completely dechlorinate TCE to ethene (C2H4). Acetylene (C2H2) occurs in TCE-contaminated sites as a consequence of chemical degradation of TCE. Yet acetylene inhibits a variety of microbial processes including methanogesis and reductive dechlorination. Pelobacter acetylenicus and related species can metabolize acetylene via acetylene hydratase and acetaldehyde dismutatse thereby generating acetate and H2 as endproducts, which could serve as electron donor and carbon source for growth of D. mccartyi. We found that 1mM acetylene (aqueous) inhibits growth of D. mccartyi strain 195 on 0.3 mM TCE, but that the inhibition was removed after 12 days with the addition of an acetylene-utilizing isolate from San Francisco Bay, Pelobacter strain SFB93. TCE did not inhibit the growth of this Pelobacter at the concentrations tested (0.1-0.5 mM) and TCE was not consumed by strain SFB93. Co-cultures of strain 195 with strain SFB93 at 5% inoculation were established in 120 mL serum bottles containing 40 mL defined medium. TCE was supplied at a liquid concentration of 0.1 mM, with 0.1 mM acetylene and N2/CO2 (90:10 v/v) headspace at 34 °C. Co-cultures were subsequently transferred (5% vol/vol inoculation) to generate subcultures after 20 μmol TCE was reduced to VC and 36 μmol acetylene was depleted. Aqueous H2 ranged from 114 to 217 nM during TCE-dechlorination, and the cell yield of strain 195 was 3.7 ±0.3 × 107 cells μmol-1 Cl- released. In a D. mccartyi-containing enrichment culture (ANAS) under the same conditions as above, it was found that inhibition of dechlorination by acetylene was reversed after 19 days by adding SFB93. Thus we showed that a co-culture of Pelobacter SFB93 and D. mccartyi 195 could be maintained with C2H2 as the electron donor and carbon source while TCE served as the electron acceptor. Inhibition by C2H2 of reductive dechlorination in both the D. mccartyi isolate and the enrichment culture ANAS were observed, but the inhibition was eliminated by adding Pelobacter SFB93 to the cultures. These results will help facilitate the optimization of TCE-bioremediation at contaminated sites containing both TCE and C2H2.

  6. Calibration Variability of 15 High Use Life Fitness Cycle Ergometers

    DTIC Science & Technology

    2013-12-02

    minutes Table 6.0: ACSM Predicted 10 Minute Calories Watts 10 Min Indicated Kcal Predicted VO2 (L/Min) ACSM Predicted 10 Min...144 13 322 20 6 49 7.5 171 13.5 361 19.5 8 63 7 198 13.5 400 19.5 10 77 7 224 13 440 20 Total 71 132 197 RPM 60 60.7...min 300w Kcal/min Hours on Bike 0 45 138 285 3474 2 59 7 163 12.5 323 19 4 73 7 189 13 361 19 6 87 7 215 13 400 19.5 8 102 7.5 141

  7. Observation of low-lying resonances in the quasicontinuum of 195,196Pt and enhanced astrophysical reaction rates

    DOE PAGES

    Giacoppo, F.; Bello Garrote, F. L.; Eriksen, T. K.; ...

    2015-05-28

    An excess of strength on the low-energy tail of the giant dipole resonance recently has been observed in the γ-decay from the quasicontinuum of 195,196Pt. The nature of this phenomenon is not yet fully investigated. If this feature is present also in the γ-ray strength of the neutron-rich isotopes, it can affect the neutron-capture reactions involved in the formation of heavy-elements in stellar nucleosynthesis. The experimental level density and γ-ray strength function of 195,196Pt are presented together with preliminary calculations of the corresponding neutron-capture cross sections.

  8. 49 CFR 195.262 - Pumping equipment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... PIPELINE Construction § 195.262 Pumping equipment. (a) Adequate ventilation must be provided in pump... provided in each pump station: (1) Safety devices that prevent overpressuring of pumping equipment..., pumping equipment must be installed on property that is under the control of the operator and at least 15...

  9. 49 CFR 195.262 - Pumping equipment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... PIPELINE Construction § 195.262 Pumping equipment. (a) Adequate ventilation must be provided in pump... provided in each pump station: (1) Safety devices that prevent overpressuring of pumping equipment..., pumping equipment must be installed on property that is under the control of the operator and at least 15...

  10. 49 CFR 195.262 - Pumping equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PIPELINE Construction § 195.262 Pumping equipment. (a) Adequate ventilation must be provided in pump... provided in each pump station: (1) Safety devices that prevent overpressuring of pumping equipment..., pumping equipment must be installed on property that is under the control of the operator and at least 15...

  11. 49 CFR 195.262 - Pumping equipment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... PIPELINE Construction § 195.262 Pumping equipment. (a) Adequate ventilation must be provided in pump... provided in each pump station: (1) Safety devices that prevent overpressuring of pumping equipment..., pumping equipment must be installed on property that is under the control of the operator and at least 15...

  12. 7 CFR 3015.195 - Subgrants and cost-type contracts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...-21 would apply to the costs incurred by the institution of higher education even though OMB Circular A-87 would apply to the costs incurred by the State. ... 7 Agriculture 15 2010-01-01 2010-01-01 false Subgrants and cost-type contracts. 3015.195 Section...

  13. 49 CFR 195.59 - Abandonment or deactivation of facilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Abandonment or deactivation of facilities. 195.59... Abandonment or deactivation of facilities. For each abandoned offshore pipeline facility or each abandoned onshore pipeline facility that crosses over, under or through a commercially navigable waterway, the last...

  14. 49 CFR 195.505 - Qualification program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... that the individual's performance of a covered task contributed to an accident as defined in Part 195... tasks; (b) Ensure through evaluation that individuals performing covered tasks are qualified; (c) Allow individuals that are not qualified pursuant to this subpart to perform a covered task if directed and observed...

  15. 46 CFR 195.03-1 - Installation and details.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Marine Engineering Systems § 195.03-1 Installation and details. (a) The installation of all systems of a marine engineering nature, together with the details of... (Marine Engineering) of this chapter. Systems of this type include the following: Steering Systems. Bilge...

  16. 40 CFR 195.30 - Failure to remit fee.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROGRAMS RADON PROFICIENCY PROGRAMS Fees § 195.30 Failure to remit fee. EPA will not process an application or continue a participant's listing in the National Radon Measurement Proficiency program, individual proficiency component of the RMP program, or the National Radon Contractor Proficiency program until the...

  17. 49 CFR 173.195 - Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Hydrogen cyanide, anhydrous, stabilized... Hazardous Materials Other Than Class 1 and Class 7 § 173.195 Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution). (a) Hydrogen cyanide, anhydrous, stabilized, must be packed in...

  18. 49 CFR 173.195 - Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Hydrogen cyanide, anhydrous, stabilized... Hazardous Materials Other Than Class 1 and Class 7 § 173.195 Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution). (a) Hydrogen cyanide, anhydrous, stabilized, must be packed in...

  19. 49 CFR 173.195 - Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Hydrogen cyanide, anhydrous, stabilized... Hazardous Materials Other Than Class 1 and Class 7 § 173.195 Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution). (a) Hydrogen cyanide, anhydrous, stabilized, must be packed in...

  20. 49 CFR 173.195 - Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Hydrogen cyanide, anhydrous, stabilized... Hazardous Materials Other Than Class 1 and Class 7 § 173.195 Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution). (a) Hydrogen cyanide, anhydrous, stabilized, must be packed in...

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