Sample records for lead 195

  1. 49 CFR 195.567 - Which pipelines must have test leads and what must I do to install and maintain the leads?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Corrosion Control § 195.567 Which pipelines must have test leads and what must I do to install and maintain... corrosion control. However, this requirement does not apply until December 27, 2004 to pipelines or pipeline...

  2. 49 CFR 195.567 - Which pipelines must have test leads and what must I do to install and maintain the leads?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Corrosion Control § 195.567 Which pipelines must have test leads and what must I do to install and maintain... corrosion control. However, this requirement does not apply until December 27, 2004 to pipelines or pipeline...

  3. 49 CFR 195.567 - Which pipelines must have test leads and what must I do to install and maintain the leads?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Corrosion Control § 195.567 Which pipelines must have test leads and what must I do to install and maintain... corrosion control. However, this requirement does not apply until December 27, 2004 to pipelines or pipeline...

  4. 49 CFR 195.567 - Which pipelines must have test leads and what must I do to install and maintain the leads?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Corrosion Control § 195.567 Which pipelines must have test leads and what must I do to install and maintain... corrosion control. However, this requirement does not apply until December 27, 2004 to pipelines or pipeline...

  5. 49 CFR 195.48 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 195.48 Section 195.48 Transportation Other... Annual, Accident, and Safety-Related Condition Reporting § 195.48 Scope. This subpart prescribes... 7000-1.1) required by § 195.49 or to provide the estimate of total miles that could affect high...

  6. 7 CFR 800.195 - Delegations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false Delegations. 800.195 Section 800.195 Agriculture... ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE), DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS Delegations, Designations, Approvals, Contracts, and Conflicts of Interest § 800.195 Delegations. (a) General. Eligible...

  7. 7 CFR 800.195 - Delegations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Delegations. 800.195 Section 800.195 Agriculture... ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE), DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS Delegations, Designations, Approvals, Contracts, and Conflicts of Interest § 800.195 Delegations. (a) General. Eligible...

  8. 49 CFR 195.408 - Communications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Communications. 195.408 Section 195.408... PIPELINE Operation and Maintenance § 195.408 Communications. (a) Each operator must have a communication... system. (b) The communication system required by paragraph (a) of this section must, as a minimum...

  9. 49 CFR 195.408 - Communications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Communications. 195.408 Section 195.408... PIPELINE Operation and Maintenance § 195.408 Communications. (a) Each operator must have a communication... system. (b) The communication system required by paragraph (a) of this section must, as a minimum...

  10. 49 CFR 195.124 - Closures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Closures. 195.124 Section 195.124 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.124...

  11. 49 CFR 195.124 - Closures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Closures. 195.124 Section 195.124 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.124...

  12. 49 CFR 195.124 - Closures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Closures. 195.124 Section 195.124 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.124...

  13. 49 CFR 195.124 - Closures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Closures. 195.124 Section 195.124 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.124...

  14. 49 CFR 195.124 - Closures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Closures. 195.124 Section 195.124 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.124...

  15. 49 CFR 195.408 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Communications. 195.408 Section 195.408... PIPELINE Operation and Maintenance § 195.408 Communications. (a) Each operator must have a communication... system. (b) The communication system required by paragraph (a) of this section must, as a minimum...

  16. 49 CFR 195.111 - Fracture propagation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Fracture propagation. 195.111 Section 195.111... PIPELINE Design Requirements § 195.111 Fracture propagation. A carbon dioxide pipeline system must be designed to mitigate the effects of fracture propagation. [Amdt. 195-45, 56 FR 26926, June 12, 1991] ...

  17. 49 CFR 195.111 - Fracture propagation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Fracture propagation. 195.111 Section 195.111... PIPELINE Design Requirements § 195.111 Fracture propagation. A carbon dioxide pipeline system must be designed to mitigate the effects of fracture propagation. [Amdt. 195-45, 56 FR 26926, June 12, 1991] ...

  18. 49 CFR 195.111 - Fracture propagation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Fracture propagation. 195.111 Section 195.111... PIPELINE Design Requirements § 195.111 Fracture propagation. A carbon dioxide pipeline system must be designed to mitigate the effects of fracture propagation. [Amdt. 195-45, 56 FR 26926, June 12, 1991] ...

  19. 49 CFR 195.111 - Fracture propagation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Fracture propagation. 195.111 Section 195.111... PIPELINE Design Requirements § 195.111 Fracture propagation. A carbon dioxide pipeline system must be designed to mitigate the effects of fracture propagation. [Amdt. 195-45, 56 FR 26926, June 12, 1991] ...

  20. 49 CFR 195.111 - Fracture propagation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Fracture propagation. 195.111 Section 195.111... PIPELINE Design Requirements § 195.111 Fracture propagation. A carbon dioxide pipeline system must be designed to mitigate the effects of fracture propagation. [Amdt. 195-45, 56 FR 26926, June 12, 1991] ...

  1. 49 CFR 195.54 - Accident reports.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Accident reports. 195.54 Section 195.54... PIPELINE Annual, Accident, and Safety-Related Condition Reporting § 195.54 Accident reports. (a) Each operator that experiences an accident that is required to be reported under § 195.50 shall as soon as...

  2. 49 CFR 195.48 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Scope. 195.48 Section 195.48 Transportation Other... Annual, Accident, and Safety-Related Condition Reporting § 195.48 Scope. This Subpart prescribes... report form PHMSA F 7000-1.1 associated with IM or high consequence areas. [76 FR 25588, May 5, 2011] ...

  3. 32 CFR 195.10 - Hearings.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Hearings. 195.10 Section 195.10 National Defense... RIGHTS ACT OF 1964 § 195.10 Hearings. (a) Opportunity for hearing. Whenever an opportunity for a hearing... recipient may request of the responsible Department official that the matter be scheduled for hearing or (2...

  4. 32 CFR 195.10 - Hearings.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Hearings. 195.10 Section 195.10 National Defense... RIGHTS ACT OF 1964 § 195.10 Hearings. (a) Opportunity for hearing. Whenever an opportunity for a hearing... recipient may request of the responsible Department official that the matter be scheduled for hearing or (2...

  5. 49 CFR 195.310 - Records.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Records. 195.310 Section 195.310 Transportation... PIPELINE Pressure Testing § 195.310 Records. (a) A record must be made of each pressure test required by this subpart, and the record of the latest test must be retained as long as the facility tested is in...

  6. 49 CFR 195.310 - Records.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Records. 195.310 Section 195.310 Transportation... PIPELINE Pressure Testing § 195.310 Records. (a) A record must be made of each pressure test required by this subpart, and the record of the latest test must be retained as long as the facility tested is in...

  7. 49 CFR 195.310 - Records.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Records. 195.310 Section 195.310 Transportation... PIPELINE Pressure Testing § 195.310 Records. (a) A record must be made of each pressure test required by this subpart, and the record of the latest test must be retained as long as the facility tested is in...

  8. 40 CFR 68.195 - Required corrections.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 15 2011-07-01 2011-07-01 false Required corrections. 68.195 Section 68.195 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.195 Required corrections. The owner or...

  9. 49 CFR 195.266 - Construction records.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Construction records. 195.266 Section 195.266 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.266 Construction records. A complete record that shows the following must be...

  10. 49 CFR 195.266 - Construction records.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Construction records. 195.266 Section 195.266 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.266 Construction records. A complete record that shows the following must be...

  11. 49 CFR 195.130 - Fabricated assemblies.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Fabricated assemblies. 195.130 Section 195.130 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Design Requirements § 195.130 Fabricated assemblies. Each fabricated assembly to be installed in a...

  12. 49 CFR 195.130 - Fabricated assemblies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Fabricated assemblies. 195.130 Section 195.130 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Design Requirements § 195.130 Fabricated assemblies. Each fabricated assembly to be installed in a...

  13. 49 CFR 195.130 - Fabricated assemblies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Fabricated assemblies. 195.130 Section 195.130 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Design Requirements § 195.130 Fabricated assemblies. Each fabricated assembly to be installed in a...

  14. 49 CFR 195.130 - Fabricated assemblies.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Fabricated assemblies. 195.130 Section 195.130 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Design Requirements § 195.130 Fabricated assemblies. Each fabricated assembly to be installed in a...

  15. 49 CFR 195.130 - Fabricated assemblies.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Fabricated assemblies. 195.130 Section 195.130 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Design Requirements § 195.130 Fabricated assemblies. Each fabricated assembly to be installed in a...

  16. 49 CFR 195.224 - Welding: Weather.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welding: Weather. 195.224 Section 195.224 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.224 Welding: Weather. Welding must be protected from weather conditions that...

  17. 49 CFR 195.102 - Design temperature.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Design temperature. 195.102 Section 195.102 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Design Requirements § 195.102 Design temperature. (a) Material for components of the system must...

  18. 49 CFR 195.102 - Design temperature.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Design temperature. 195.102 Section 195.102 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Design Requirements § 195.102 Design temperature. (a) Material for components of the system must...

  19. 49 CFR 195.50 - Reporting accidents.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Reporting accidents. 195.50 Section 195.50 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Annual, Accident, and Safety-Related Condition Reporting § 195.50 Reporting accidents. An accident...

  20. 49 CFR 195.50 - Reporting accidents.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Reporting accidents. 195.50 Section 195.50 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Annual, Accident, and Safety-Related Condition Reporting § 195.50 Reporting accidents. An accident...

  1. 49 CFR 195.224 - Welding: Weather.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Welding: Weather. 195.224 Section 195.224 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.224 Welding: Weather. Welding must be protected from weather conditions that...

  2. 49 CFR 195.224 - Welding: Weather.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Welding: Weather. 195.224 Section 195.224 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.224 Welding: Weather. Welding must be protected from weather conditions that...

  3. 49 CFR 195.224 - Welding: Weather.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Welding: Weather. 195.224 Section 195.224 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.224 Welding: Weather. Welding must be protected from weather conditions that...

  4. 49 CFR 195.224 - Welding: Weather.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Welding: Weather. 195.224 Section 195.224 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.224 Welding: Weather. Welding must be protected from weather conditions that...

  5. 40 CFR 68.195 - Required corrections.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Required corrections. 68.195 Section 68.195 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.195 Required corrections. The owner or...

  6. 49 CFR 195.262 - Pumping equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Pumping equipment. 195.262 Section 195.262... PIPELINE Construction § 195.262 Pumping equipment. (a) Adequate ventilation must be provided in pump... provided in each pump station: (1) Safety devices that prevent overpressuring of pumping equipment...

  7. 49 CFR 195.206 - Material inspection.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Material inspection. 195.206 Section 195.206 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.206 Material inspection. No pipe or other component may be installed in a...

  8. 49 CFR 195.206 - Material inspection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Material inspection. 195.206 Section 195.206 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.206 Material inspection. No pipe or other component may be installed in a...

  9. 49 CFR 195.108 - External pressure.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false External pressure. 195.108 Section 195.108... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.108 External pressure. Any external pressure that will be exerted on the...

  10. 49 CFR 195.108 - External pressure.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false External pressure. 195.108 Section 195.108... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.108 External pressure. Any external pressure that will be exerted on the...

  11. 49 CFR 195.108 - External pressure.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false External pressure. 195.108 Section 195.108... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.108 External pressure. Any external pressure that will be exerted on the...

  12. 49 CFR 195.304 - Test pressure.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Test pressure. 195.304 Section 195.304... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.304 Test pressure. The test pressure for each pressure test conducted under...

  13. 49 CFR 195.108 - External pressure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false External pressure. 195.108 Section 195.108... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.108 External pressure. Any external pressure that will be exerted on the...

  14. 49 CFR 195.304 - Test pressure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Test pressure. 195.304 Section 195.304... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.304 Test pressure. The test pressure for each pressure test conducted under...

  15. 49 CFR 195.304 - Test pressure.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Test pressure. 195.304 Section 195.304... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.304 Test pressure. The test pressure for each pressure test conducted under...

  16. 49 CFR 195.304 - Test pressure.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Test pressure. 195.304 Section 195.304... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.304 Test pressure. The test pressure for each pressure test conducted under...

  17. 49 CFR 195.108 - External pressure.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false External pressure. 195.108 Section 195.108... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.108 External pressure. Any external pressure that will be exerted on the...

  18. 49 CFR 195.206 - Material inspection.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Material inspection. 195.206 Section 195.206 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.206 Material inspection. No pipe or other component may be installed in a...

  19. 49 CFR 195.210 - Pipeline location.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Pipeline location. 195.210 Section 195.210 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.210 Pipeline location. (a) Pipeline right-of-way must be selected to avoid, as...

  20. 49 CFR 195.430 - Firefighting equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Firefighting equipment. 195.430 Section 195.430... PIPELINE Operation and Maintenance § 195.430 Firefighting equipment. Each operator shall maintain adequate firefighting equipment at each pump station and breakout tank area. The equipment must be— (a) In proper...

  1. 46 CFR 195.09-5 - General.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false General. 195.09-5 Section 195.09-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Scientific Equipment § 195.09-5 General. (a) All scientific equipment shall be...

  2. 46 CFR 195.09-5 - General.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false General. 195.09-5 Section 195.09-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Scientific Equipment § 195.09-5 General. (a) All scientific equipment shall be...

  3. 46 CFR 195.30-5 - General.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false General. 195.30-5 Section 195.30-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Protection From Refrigerants § 195.30-5 General. (a) Each self-contained breathing...

  4. 49 CFR 195.440 - Public awareness.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Public awareness. 195.440 Section 195.440... PIPELINE Operation and Maintenance § 195.440 Public awareness. (a) Each pipeline operator must develop and implement a written continuing public education program that follows the guidance provided in the American...

  5. 49 CFR 195.440 - Public awareness.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Public awareness. 195.440 Section 195.440... PIPELINE Operation and Maintenance § 195.440 Public awareness. (a) Each pipeline operator must develop and implement a written continuing public education program that follows the guidance provided in the American...

  6. 46 CFR 195.07-1 - Application.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Application. 195.07-1 Section 195.07-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Anchors, Chains, and Hawsers § 195.07-1 Application. (a) The provisions of...

  7. 46 CFR 195.11-1 - Application.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Application. 195.11-1 Section 195.11-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Portable Vans and Tanks § 195.11-1 Application. (a) The provisions of this...

  8. 12 CFR 195.24 - Service test.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Service test. 195.24 Section 195.24 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY COMMUNITY REINVESTMENT Standards for Assessing Performance § 195.24 Service test. (a) Scope of test. The service test evaluates a savings...

  9. 49 CFR 195.102 - Design temperature.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Design temperature. 195.102 Section 195.102... PIPELINE Design Requirements § 195.102 Design temperature. (a) Material for components of the system must be chosen for the temperature environment in which the components will be used so that the pipeline...

  10. 49 CFR 195.102 - Design temperature.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Design temperature. 195.102 Section 195.102... PIPELINE Design Requirements § 195.102 Design temperature. (a) Material for components of the system must be chosen for the temperature environment in which the components will be used so that the pipeline...

  11. 49 CFR 195.306 - Test medium.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Test medium. 195.306 Section 195.306... PIPELINE Pressure Testing § 195.306 Test medium. (a) Except as provided in paragraphs (b), (c), and (d) of this section, water must be used as the test medium. (b) Except for offshore pipelines, liquid...

  12. 49 CFR 195.214 - Welding procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welding procedures. 195.214 Section 195.214... PIPELINE Construction § 195.214 Welding procedures. (a) Welding must be performed by a qualified welder in accordance with welding procedures qualified under Section 5 of API 1104 or Section IX of the ASME Boiler and...

  13. 49 CFR 195.306 - Test medium.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Test medium. 195.306 Section 195.306... PIPELINE Pressure Testing § 195.306 Test medium. (a) Except as provided in paragraphs (b), (c), and (d) of this section, water must be used as the test medium. (b) Except for offshore pipelines, liquid...

  14. 49 CFR 195.304 - Test pressure.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Test pressure. 195.304 Section 195.304... PIPELINE Pressure Testing § 195.304 Test pressure. The test pressure for each pressure test conducted under... case of a pipeline that is not visually inspected for leakage during the test, for at least an...

  15. 12 CFR 195.22 - Lending test.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Lending test. 195.22 Section 195.22 Banks and... Assessing Performance § 195.22 Lending test. (a) Scope of test. (1) The lending test evaluates a savings... lending test except the community development lending criterion. (b) Performance criteria. The appropriate...

  16. 49 CFR 195.214 - Welding procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Welding procedures. 195.214 Section 195.214... PIPELINE Construction § 195.214 Welding procedures. (a) Welding must be performed by a qualified welder in accordance with welding procedures qualified under Section 5 of API 1104 or Section IX of the ASME Boiler and...

  17. 49 CFR 195.214 - Welding procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Welding procedures. 195.214 Section 195.214... PIPELINE Construction § 195.214 Welding procedures. (a) Welding must be performed by a qualified welder in accordance with welding procedures qualified under Section 5 of API 1104 or Section IX of the ASME Boiler and...

  18. 49 CFR 195.214 - Welding procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Welding procedures. 195.214 Section 195.214... PIPELINE Construction § 195.214 Welding procedures. (a) Welding must be performed by a qualified welder in accordance with welding procedures qualified under Section 5 of API 1104 or Section IX of the ASME Boiler and...

  19. 49 CFR 195.214 - Welding procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Welding procedures. 195.214 Section 195.214... PIPELINE Construction § 195.214 Welding procedures. (a) Welding must be performed by a qualified welder in accordance with welding procedures qualified under Section 5 of API 1104 or Section IX of the ASME Boiler and...

  20. 21 CFR 137.195 - Crushed wheat.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Crushed wheat. 137.195 Section 137.195 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... Related Products § 137.195 Crushed wheat. Crushed wheat, coarse ground wheat, is the food prepared by so...

  1. 12 CFR 195.23 - Investment test.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Investment test. 195.23 Section 195.23 Banks... for Assessing Performance § 195.23 Investment test. (a) Scope of test. The investment test evaluates a... lending or service tests may not be considered under the investment test. (c) Affiliate investment. At a...

  2. 40 CFR 46.195 - Project period.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Project period. 46.195 Section 46.195... During the Fellowship § 46.195 Project period. Based on the “Date Fellow Will Enter on Duty” which you enter on the Activation Notice (see § 46.185(a)), EPA will establish the project period for the...

  3. 40 CFR 46.195 - Project period.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Project period. 46.195 Section 46.195... During the Fellowship § 46.195 Project period. Based on the “Date Fellow Will Enter on Duty” which you enter on the Activation Notice (see § 46.185(a)), EPA will establish the project period for the...

  4. 40 CFR 46.195 - Project period.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Project period. 46.195 Section 46.195... During the Fellowship § 46.195 Project period. Based on the “Date Fellow Will Enter on Duty” which you enter on the Activation Notice (see § 46.185(a)), EPA will establish the project period for the...

  5. 40 CFR 46.195 - Project period.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Project period. 46.195 Section 46.195... During the Fellowship § 46.195 Project period. Based on the “Date Fellow Will Enter on Duty” which you enter on the Activation Notice (see § 46.185(a)), EPA will establish the project period for the...

  6. 40 CFR 46.195 - Project period.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Project period. 46.195 Section 46.195... During the Fellowship § 46.195 Project period. Based on the “Date Fellow Will Enter on Duty” which you enter on the Activation Notice (see § 46.185(a)), EPA will establish the project period for the...

  7. 49 CFR 195.207 - Transportation of pipe.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... in accordance with API Recommended Practice 5L1 (incorporated by reference, see § 195.3). (b) Ship or... with API Recommended Practice 5LW (incorporated by reference, see § 195.3). [ Amdt. 195-94, 75 FR 48606...

  8. 49 CFR 195.207 - Transportation of pipe.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... in accordance with API Recommended Practice 5L1 (incorporated by reference, see § 195.3). (b) Ship or... with API Recommended Practice 5LW (incorporated by reference, see § 195.3). [ Amdt. 195-94, 75 FR 48606...

  9. 10 CFR 19.5 - Communications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Communications. 19.5 Section 19.5 Energy NUCLEAR... Communications. Except where otherwise specified in this part, all communications and reports concerning the... Regulatory Commission Regional Office listed in Appendix D of part 20 of this chapter. Communications...

  10. 10 CFR 19.5 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Communications. 19.5 Section 19.5 Energy NUCLEAR... Communications. Except where otherwise specified in this part, all communications and reports concerning the... Regulatory Commission Regional Office listed in Appendix D of part 20 of this chapter. Communications...

  11. 10 CFR 19.5 - Communications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Communications. 19.5 Section 19.5 Energy NUCLEAR... Communications. Except where otherwise specified in this part, all communications and reports concerning the... Regulatory Commission Regional Office listed in Appendix D of part 20 of this chapter. Communications...

  12. 32 CFR 195.4 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Policy. 195.4 Section 195.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OF THE DEPARTMENT OF DEFENSE-EFFECTUATION OF TITLE VI OF THE CIVIL...

  13. 32 CFR 195.4 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Policy. 195.4 Section 195.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OF THE DEPARTMENT OF DEFENSE-EFFECTUATION OF TITLE VI OF THE CIVIL...

  14. 32 CFR 195.4 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Policy. 195.4 Section 195.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OF THE DEPARTMENT OF DEFENSE-EFFECTUATION OF TITLE VI OF THE CIVIL...

  15. 32 CFR 195.4 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Policy. 195.4 Section 195.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OF THE DEPARTMENT OF DEFENSE-EFFECTUATION OF TITLE VI OF THE CIVIL...

  16. 32 CFR 195.4 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Policy. 195.4 Section 195.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OF THE DEPARTMENT OF DEFENSE-EFFECTUATION OF TITLE VI OF THE CIVIL...

  17. 16 CFR 1.95 - Procedures upon election.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Procedures upon election. 1.95 Section 1.95 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE GENERAL PROCEDURES Penalties for Violation of Appliance Labeling Rules § 1.95 Procedures upon election. (a) After...

  18. 49 CFR 195.444 - CPM leak detection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false CPM leak detection. 195.444 Section 195.444... PIPELINE Operation and Maintenance § 195.444 CPM leak detection. Each computational pipeline monitoring (CPM) leak detection system installed on a hazardous liquid pipeline transporting liquid in single...

  19. 49 CFR 195.216 - Welding: Miter joints.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welding: Miter joints. 195.216 Section 195.216 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.216 Welding: Miter joints. A miter joint is not permitted (not including...

  20. 49 CFR 195.104 - Variations in pressure.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Variations in pressure. 195.104 Section 195.104... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.104 Variations in pressure. If, within a pipeline system, two or more...

  1. 49 CFR 195.104 - Variations in pressure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Variations in pressure. 195.104 Section 195.104... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.104 Variations in pressure. If, within a pipeline system, two or more...

  2. 49 CFR 195.104 - Variations in pressure.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Variations in pressure. 195.104 Section 195.104... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.104 Variations in pressure. If, within a pipeline system, two or more...

  3. 49 CFR 195.104 - Variations in pressure.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Variations in pressure. 195.104 Section 195.104... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.104 Variations in pressure. If, within a pipeline system, two or more...

  4. 49 CFR 195.104 - Variations in pressure.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Variations in pressure. 195.104 Section 195.104... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.104 Variations in pressure. If, within a pipeline system, two or more...

  5. 49 CFR 195.254 - Above ground components.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Above ground components. 195.254 Section 195.254 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.254 Above ground components. (a) Any component may be installed above ground in...

  6. 49 CFR 195.254 - Above ground components.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Above ground components. 195.254 Section 195.254 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.254 Above ground components. (a) Any component may be installed above ground in...

  7. 49 CFR 195.216 - Welding: Miter joints.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Welding: Miter joints. 195.216 Section 195.216 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.216 Welding: Miter joints. A miter joint is not permitted (not including...

  8. 49 CFR 195.216 - Welding: Miter joints.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Welding: Miter joints. 195.216 Section 195.216 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.216 Welding: Miter joints. A miter joint is not permitted (not including...

  9. 49 CFR 195.216 - Welding: Miter joints.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Welding: Miter joints. 195.216 Section 195.216 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.216 Welding: Miter joints. A miter joint is not permitted (not including...

  10. 49 CFR 195.216 - Welding: Miter joints.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Welding: Miter joints. 195.216 Section 195.216 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.216 Welding: Miter joints. A miter joint is not permitted (not including...

  11. 49 CFR 195.436 - Security of facilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Security of facilities. 195.436 Section 195.436... PIPELINE Operation and Maintenance § 195.436 Security of facilities. Each operator shall provide protection for each pumping station and breakout tank area and other exposed facility (such as scraper traps...

  12. 27 CFR 41.195 - Trade name certificate.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Trade name certificate. 41.195 Section 41.195 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU..., AND PROCESSED TOBACCO Tobacco Products Importers § 41.195 Trade name certificate. Every person, before...

  13. 27 CFR 41.195 - Trade name certificate.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Trade name certificate. 41.195 Section 41.195 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU..., AND PROCESSED TOBACCO Tobacco Products Importers § 41.195 Trade name certificate. Every person, before...

  14. 27 CFR 41.195 - Trade name certificate.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Trade name certificate. 41.195 Section 41.195 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU..., AND PROCESSED TOBACCO Tobacco Products Importers § 41.195 Trade name certificate. Every person, before...

  15. 27 CFR 41.195 - Trade name certificate.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Trade name certificate. 41.195 Section 41.195 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU..., AND PROCESSED TOBACCO Tobacco Products Importers § 41.195 Trade name certificate. Every person that...

  16. 27 CFR 41.195 - Trade name certificate.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Trade name certificate. 41.195 Section 41.195 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU..., AND PROCESSED TOBACCO Tobacco Products Importers § 41.195 Trade name certificate. Every person, before...

  17. 49 CFR 195.406 - Maximum operating pressure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HAZARDOUS LIQUIDS BY PIPELINE Operation and Maintenance § 195.406 Maximum operating pressure. (a) Except for surge pressures and other variations from normal operations, no operator may operate a pipeline at a... 49 Transportation 3 2010-10-01 2010-10-01 false Maximum operating pressure. 195.406 Section 195...

  18. 49 CFR 195.406 - Maximum operating pressure.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... HAZARDOUS LIQUIDS BY PIPELINE Operation and Maintenance § 195.406 Maximum operating pressure. (a) Except for surge pressures and other variations from normal operations, no operator may operate a pipeline at a... 49 Transportation 3 2012-10-01 2012-10-01 false Maximum operating pressure. 195.406 Section 195...

  19. 49 CFR 195.406 - Maximum operating pressure.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... HAZARDOUS LIQUIDS BY PIPELINE Operation and Maintenance § 195.406 Maximum operating pressure. (a) Except for surge pressures and other variations from normal operations, no operator may operate a pipeline at a... 49 Transportation 3 2014-10-01 2014-10-01 false Maximum operating pressure. 195.406 Section 195...

  20. 49 CFR 195.406 - Maximum operating pressure.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... HAZARDOUS LIQUIDS BY PIPELINE Operation and Maintenance § 195.406 Maximum operating pressure. (a) Except for surge pressures and other variations from normal operations, no operator may operate a pipeline at a... 49 Transportation 3 2011-10-01 2011-10-01 false Maximum operating pressure. 195.406 Section 195...

  1. 49 CFR 195.406 - Maximum operating pressure.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... HAZARDOUS LIQUIDS BY PIPELINE Operation and Maintenance § 195.406 Maximum operating pressure. (a) Except for surge pressures and other variations from normal operations, no operator may operate a pipeline at a... 49 Transportation 3 2013-10-01 2013-10-01 false Maximum operating pressure. 195.406 Section 195...

  2. 40 CFR 35.195 - Maximum federal share.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Maximum federal share. 35.195 Section 35.195 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE... 1443(b)) § 35.195 Maximum federal share. The Regional Administrator may provide a maximum of 75 percent...

  3. 46 CFR 195.11-30 - Portable tanks.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Portable tanks. 195.11-30 Section 195.11-30 Shipping... AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Portable Vans and Tanks § 195.11-30 Portable tanks. (a) All portable tanks, whether hazardous or nonhazardous commodities, shall be loaded and stowed in accordance...

  4. 46 CFR 195.11-30 - Portable tanks.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Portable tanks. 195.11-30 Section 195.11-30 Shipping... AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Portable Vans and Tanks § 195.11-30 Portable tanks. (a) All portable tanks, whether hazardous or nonhazardous commodities, shall be loaded and stowed in accordance...

  5. 46 CFR 195.11-30 - Portable tanks.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Portable tanks. 195.11-30 Section 195.11-30 Shipping... AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Portable Vans and Tanks § 195.11-30 Portable tanks. (a) All portable tanks, whether hazardous or nonhazardous commodities, shall be loaded and stowed in accordance...

  6. 46 CFR 195.11-30 - Portable tanks.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Portable tanks. 195.11-30 Section 195.11-30 Shipping... AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Portable Vans and Tanks § 195.11-30 Portable tanks. (a) All portable tanks, whether hazardous or nonhazardous commodities, shall be loaded and stowed in accordance...

  7. 46 CFR 195.11-30 - Portable tanks.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Portable tanks. 195.11-30 Section 195.11-30 Shipping... AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Portable Vans and Tanks § 195.11-30 Portable tanks. (a) All portable tanks, whether hazardous or nonhazardous commodities, shall be loaded and stowed in accordance...

  8. 49 CFR 195.234 - Welds: Nondestructive testing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welds: Nondestructive testing. 195.234 Section 195... HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.234 Welds: Nondestructive testing. (a) A weld may be... weld. (b) Any nondestructive testing of welds must be performed— (1) In accordance with a written set...

  9. 49 CFR 195.226 - Welding: Arc burns.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welding: Arc burns. 195.226 Section 195.226 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.226 Welding: Arc burns. (a) Each arc burn must be repaired. (b) An arc burn may...

  10. 49 CFR 195.226 - Welding: Arc burns.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Welding: Arc burns. 195.226 Section 195.226 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.226 Welding: Arc burns. (a) Each arc burn must be repaired. (b) An arc burn may...

  11. 49 CFR 195.226 - Welding: Arc burns.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Welding: Arc burns. 195.226 Section 195.226 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.226 Welding: Arc burns. (a) Each arc burn must be repaired. (b) An arc burn may...

  12. 49 CFR 195.226 - Welding: Arc burns.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Welding: Arc burns. 195.226 Section 195.226 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.226 Welding: Arc burns. (a) Each arc burn must be repaired. (b) An arc burn may...

  13. 49 CFR 195.226 - Welding: Arc burns.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Welding: Arc burns. 195.226 Section 195.226 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.226 Welding: Arc burns. (a) Each arc burn must be repaired. (b) An arc burn may...

  14. 49 CFR 195.106 - Internal design pressure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Internal design pressure. 195.106 Section 195.106... PIPELINE Design Requirements § 195.106 Internal design pressure. (a) Internal design pressure for the pipe in a pipeline is determined in accordance with the following formula: P=(2St/D)×E×F P=Internal design...

  15. 49 CFR 195.106 - Internal design pressure.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Internal design pressure. 195.106 Section 195.106... PIPELINE Design Requirements § 195.106 Internal design pressure. (a) Internal design pressure for the pipe in a pipeline is determined in accordance with the following formula: P=(2St/D)×E×F P=Internal design...

  16. 49 CFR 195.212 - Bending of pipe.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Bending of pipe. 195.212 Section 195.212... PIPELINE Construction § 195.212 Bending of pipe. (a) Pipe must not have a wrinkle bend. (b) Each field bend must comply with the following: (1) A bend must not impair the serviceability of the pipe. (2) Each...

  17. 49 CFR 195.212 - Bending of pipe.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Bending of pipe. 195.212 Section 195.212... PIPELINE Construction § 195.212 Bending of pipe. (a) Pipe must not have a wrinkle bend. (b) Each field bend must comply with the following: (1) A bend must not impair the serviceability of the pipe. (2) Each...

  18. 49 CFR 195.222 - Welders: Qualification of welders.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... be qualified in accordance with section 6 of API 1104 (incorporated by reference, see § 195.3) or... and found acceptable under section 9 of API 1104 (incorporated by reference, see § 195.3). [Amdt. 195...

  19. 49 CFR 195.222 - Welders: Qualification of welders.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... be qualified in accordance with section 6 of API 1104 (incorporated by reference, see § 195.3) or... and found acceptable under section 9 of API 1104 (incorporated by reference, see § 195.3). [Amdt. 195...

  20. 49 CFR 195.222 - Welders: Qualification of welders.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... be qualified in accordance with section 6 of API 1104 (incorporated by reference, see § 195.3) or... and found acceptable under section 9 of API 1104 (incorporated by reference, see § 195.3). [Amdt. 195...

  1. 49 CFR 195.222 - Welders: Qualification of welders.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... be qualified in accordance with section 6 of API 1104 (incorporated by reference, see § 195.3) or... and found acceptable under section 9 of API 1104 (incorporated by reference, see § 195.3). [Amdt. 195...

  2. The line-locking hypothesis, absorption by intervening galaxies, and the z = 1.95 peak in redshifts

    NASA Technical Reports Server (NTRS)

    Burbidge, G.

    1978-01-01

    The controversy over whether the absorption spectrum in QSOs is intrinsic or extrinsic is approached with attention to the peak of redshifts at z = 1.95. Also considered are the line-locking and the intervening galaxy hypotheses. The line locking hypothesis is based on observations that certain ratios found in absorption line QSOs are preferred, and leads inevitably to the conclusion that the absorption line systems are intrinsic. The intervening galaxy hypothesis is based on absorption redshifts resulting from given absorption cross-sections of galactic clusters and the intergalactic medium, and would lead to the theoretical conclusion that most QSOs show strong absorption, a conclusion which is not supported by empirical data. The 1.95 peak, on the other hand, is most probably an intrinsic property of QSOs. The peak is enhanced by redshift, and it is noted that both an emission and an absorption redshift peak are seen at 1.95.

  3. High specific activity platinum-195m

    DOEpatents

    Mirzadeh, Saed; Du, Miting; Beets, Arnold L.; Knapp, Jr., Furn F.

    2004-10-12

    A new composition of matter includes .sup.195m Pt characterized by a specific activity of at least 30 mCi/mg Pt, generally made by method that includes the steps of: exposing .sup.193 Ir to a flux of neutrons sufficient to convert a portion of the .sup.193 Ir to .sup.195m Pt to form an irradiated material; dissolving the irradiated material to form an intermediate solution comprising Ir and Pt; and separating the Pt from the Ir by cation exchange chromatography to produce .sup.195m Pt.

  4. 49 CFR 195.410 - Line markers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Line markers. 195.410 Section 195.410 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY...

  5. 49 CFR 195.102 - Design temperature.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Design temperature. 195.102 Section 195.102 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements §...

  6. 49 CFR 195.49 - Annual report.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Annual report. 195.49 Section 195.49 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Annual, Accident, and...

  7. 49 CFR 195.54 - Accident reports.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Accident reports. 195.54 Section 195.54 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Annual, Accident, and...

  8. 49 CFR 195.426 - Scraper and sphere facilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Scraper and sphere facilities. 195.426 Section 195.426 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... HAZARDOUS LIQUIDS BY PIPELINE Operation and Maintenance § 195.426 Scraper and sphere facilities. No operator...

  9. Evaluation of robenidine analog NCL195 as a novel broad-spectrum antibacterial agent.

    PubMed

    Ogunniyi, Abiodun D; Khazandi, Manouchehr; Stevens, Andrew J; Sims, Sarah K; Page, Stephen W; Garg, Sanjay; Venter, Henrietta; Powell, Andrew; White, Karen; Petrovski, Kiro R; Laven-Law, Geraldine; Tótoli, Eliane G; Salgado, Hérida R; Pi, Hongfei; Coombs, Geoffrey W; Shinabarger, Dean L; Turnidge, John D; Paton, James C; McCluskey, Adam; Trott, Darren J

    2017-01-01

    The spread of multidrug resistance among bacterial pathogens poses a serious threat to public health worldwide. Recent approaches towards combating antimicrobial resistance include repurposing old compounds with known safety and development pathways as new antibacterial classes with novel mechanisms of action. Here we show that an analog of the anticoccidial drug robenidine (4,6-bis(2-((E)-4-methylbenzylidene)hydrazinyl)pyrimidin-2-amine; NCL195) displays potent bactericidal activity against Streptococcus pneumoniae and Staphylococcus aureus by disrupting the cell membrane potential. NCL195 was less cytotoxic to mammalian cell lines than the parent compound, showed low metabolic degradation rates by human and mouse liver microsomes, and exhibited high plasma concentration and low plasma clearance rates in mice. NCL195 was bactericidal against Acinetobacter spp and Neisseria meningitidis and also demonstrated potent activity against A. baumannii, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Enterobacter spp. in the presence of sub-inhibitory concentrations of ethylenediaminetetraacetic acid (EDTA) and polymyxin B. These findings demonstrate that NCL195 represents a new chemical lead for further medicinal chemistry and pharmaceutical development to enhance potency, solubility and selectivity against serious bacterial pathogens.

  10. Evaluation of robenidine analog NCL195 as a novel broad-spectrum antibacterial agent

    PubMed Central

    Sims, Sarah K.; Page, Stephen W.; Garg, Sanjay; Venter, Henrietta; Powell, Andrew; White, Karen; Petrovski, Kiro R.; Laven-Law, Geraldine; Tótoli, Eliane G.; Salgado, Hérida R.; Pi, Hongfei; Coombs, Geoffrey W.; Shinabarger, Dean L.; Turnidge, John D.; Paton, James C.; McCluskey, Adam; Trott, Darren J.

    2017-01-01

    The spread of multidrug resistance among bacterial pathogens poses a serious threat to public health worldwide. Recent approaches towards combating antimicrobial resistance include repurposing old compounds with known safety and development pathways as new antibacterial classes with novel mechanisms of action. Here we show that an analog of the anticoccidial drug robenidine (4,6-bis(2-((E)-4-methylbenzylidene)hydrazinyl)pyrimidin-2-amine; NCL195) displays potent bactericidal activity against Streptococcus pneumoniae and Staphylococcus aureus by disrupting the cell membrane potential. NCL195 was less cytotoxic to mammalian cell lines than the parent compound, showed low metabolic degradation rates by human and mouse liver microsomes, and exhibited high plasma concentration and low plasma clearance rates in mice. NCL195 was bactericidal against Acinetobacter spp and Neisseria meningitidis and also demonstrated potent activity against A. baumannii, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Enterobacter spp. in the presence of sub-inhibitory concentrations of ethylenediaminetetraacetic acid (EDTA) and polymyxin B. These findings demonstrate that NCL195 represents a new chemical lead for further medicinal chemistry and pharmaceutical development to enhance potency, solubility and selectivity against serious bacterial pathogens. PMID:28873428

  11. 19 CFR 10.195 - Country of origin criteria.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Country of origin criteria. 10.195 Section 10.195 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. Caribbean Basin Initiative § 10.195...

  12. 49 CFR 195.58 - Address for written reports.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Address for written reports. 195.58 Section 195.58... PIPELINE Annual, Accident, and Safety-Related Condition Reporting § 195.58 Address for written reports. Each written report required by this subpart must be made to the Office of Pipeline Safety, Pipeline...

  13. 49 CFR 195.305 - Testing of components.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.305 Testing of components. (a) Each pressure test under § 195.302 must test...

  14. 49 CFR 195.305 - Testing of components.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.305 Testing of components. (a) Each pressure test under § 195.302 must test...

  15. 49 CFR 195.305 - Testing of components.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.305 Testing of components. (a) Each pressure test under § 195.302 must test...

  16. 49 CFR 195.305 - Testing of components.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.305 Testing of components. (a) Each pressure test under § 195.302 must test...

  17. 49 CFR 195.305 - Testing of components.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.305 Testing of components. (a) Each pressure test under § 195.302 must test...

  18. 32 CFR 195.13 - Effect on other issuances.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Effect on other issuances. 195.13 Section 195.13 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED... TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 § 195.13 Effect on other issuances. All issuances heretofore...

  19. 46 CFR 195.40-1 - Pilot boarding equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Pilot boarding equipment. 195.40-1 Section 195.40-1... CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Pilot Boarding Equipment § 195.40-1 Pilot boarding equipment. (a) This section applies to each vessel that normally embarks or disembarks a pilot from a pilot...

  20. 46 CFR 195.40-1 - Pilot boarding equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Pilot boarding equipment. 195.40-1 Section 195.40-1... CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Pilot Boarding Equipment § 195.40-1 Pilot boarding equipment. (a) This section applies to each vessel that normally embarks or disembarks a pilot from a pilot...

  1. 49 CFR 195.438 - Smoking or open flames.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Smoking or open flames. 195.438 Section 195.438... PIPELINE Operation and Maintenance § 195.438 Smoking or open flames. Each operator shall prohibit smoking and open flames in each pump station area and each breakout tank area where there is a possibility of...

  2. 49 CFR 195.438 - Smoking or open flames.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Smoking or open flames. 195.438 Section 195.438... PIPELINE Operation and Maintenance § 195.438 Smoking or open flames. Each operator shall prohibit smoking and open flames in each pump station area and each breakout tank area where there is a possibility of...

  3. 49 CFR 195.438 - Smoking or open flames.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Smoking or open flames. 195.438 Section 195.438... PIPELINE Operation and Maintenance § 195.438 Smoking or open flames. Each operator shall prohibit smoking and open flames in each pump station area and each breakout tank area where there is a possibility of...

  4. 49 CFR 195.438 - Smoking or open flames.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Smoking or open flames. 195.438 Section 195.438... PIPELINE Operation and Maintenance § 195.438 Smoking or open flames. Each operator shall prohibit smoking and open flames in each pump station area and each breakout tank area where there is a possibility of...

  5. 49 CFR 195.438 - Smoking or open flames.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Smoking or open flames. 195.438 Section 195.438... PIPELINE Operation and Maintenance § 195.438 Smoking or open flames. Each operator shall prohibit smoking and open flames in each pump station area and each breakout tank area where there is a possibility of...

  6. 40 CFR 195.30 - Failure to remit fee.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Failure to remit fee. 195.30 Section... PROGRAMS RADON PROFICIENCY PROGRAMS Fees § 195.30 Failure to remit fee. EPA will not process an application... appropriate remittance provided in § 195.20(a) has been received by EPA. Failure by a currently EPA-listed...

  7. 40 CFR 195.30 - Failure to remit fee.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Failure to remit fee. 195.30 Section... PROGRAMS RADON PROFICIENCY PROGRAMS Fees § 195.30 Failure to remit fee. EPA will not process an application... appropriate remittance provided in § 195.20(a) has been received by EPA. Failure by a currently EPA-listed...

  8. 40 CFR 195.30 - Failure to remit fee.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Failure to remit fee. 195.30 Section... PROGRAMS RADON PROFICIENCY PROGRAMS Fees § 195.30 Failure to remit fee. EPA will not process an application... appropriate remittance provided in § 195.20(a) has been received by EPA. Failure by a currently EPA-listed...

  9. 49 CFR 195.208 - Welding of supports and braces.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welding of supports and braces. 195.208 Section 195.208 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.208 Welding of supports and braces. Supports or braces may...

  10. 49 CFR 195.208 - Welding of supports and braces.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Welding of supports and braces. 195.208 Section 195.208 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.208 Welding of supports and braces. Supports or braces may...

  11. 49 CFR 195.208 - Welding of supports and braces.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Welding of supports and braces. 195.208 Section 195.208 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.208 Welding of supports and braces. Supports or braces may...

  12. 49 CFR 195.208 - Welding of supports and braces.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Welding of supports and braces. 195.208 Section 195.208 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.208 Welding of supports and braces. Supports or braces may...

  13. 49 CFR 195.208 - Welding of supports and braces.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Welding of supports and braces. 195.208 Section 195.208 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.208 Welding of supports and braces. Supports or braces may...

  14. 49 CFR 195.58 - Report submission requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Report submission requirements. 195.58 Section 195.58 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Annual,...

  15. 40 CFR 792.195 - Retention of records.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... mutagenicity tests, specimens of soil, water, and plants, and wet specimens of blood, urine, feces, biological... 40 Protection of Environment 32 2011-07-01 2011-07-01 false Retention of records. 792.195 Section... ACT (CONTINUED) GOOD LABORATORY PRACTICE STANDARDS Records and Reports § 792.195 Retention of records...

  16. 40 CFR 792.195 - Retention of records.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... mutagenicity tests, specimens of soil, water, and plants, and wet specimens of blood, urine, feces, biological... 40 Protection of Environment 32 2014-07-01 2014-07-01 false Retention of records. 792.195 Section... ACT (CONTINUED) GOOD LABORATORY PRACTICE STANDARDS Records and Reports § 792.195 Retention of records...

  17. 40 CFR 160.195 - Retention of records.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... obtained from mutagenicity tests, specimens of soil, water, and plants, and wet specimens of blood, urine... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Retention of records. 160.195 Section... LABORATORY PRACTICE STANDARDS Records and Reports § 160.195 Retention of records. (a) Record retention...

  18. 40 CFR 160.195 - Retention of records.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... obtained from mutagenicity tests, specimens of soil, water, and plants, and wet specimens of blood, urine... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Retention of records. 160.195 Section... LABORATORY PRACTICE STANDARDS Records and Reports § 160.195 Retention of records. (a) Record retention...

  19. 40 CFR 160.195 - Retention of records.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... obtained from mutagenicity tests, specimens of soil, water, and plants, and wet specimens of blood, urine... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Retention of records. 160.195 Section... LABORATORY PRACTICE STANDARDS Records and Reports § 160.195 Retention of records. (a) Record retention...

  20. 40 CFR 792.195 - Retention of records.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... mutagenicity tests, specimens of soil, water, and plants, and wet specimens of blood, urine, feces, biological... 40 Protection of Environment 33 2012-07-01 2012-07-01 false Retention of records. 792.195 Section... ACT (CONTINUED) GOOD LABORATORY PRACTICE STANDARDS Records and Reports § 792.195 Retention of records...

  1. 40 CFR 792.195 - Retention of records.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... mutagenicity tests, specimens of soil, water, and plants, and wet specimens of blood, urine, feces, biological... 40 Protection of Environment 33 2013-07-01 2013-07-01 false Retention of records. 792.195 Section... ACT (CONTINUED) GOOD LABORATORY PRACTICE STANDARDS Records and Reports § 792.195 Retention of records...

  2. 40 CFR 160.195 - Retention of records.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... obtained from mutagenicity tests, specimens of soil, water, and plants, and wet specimens of blood, urine... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Retention of records. 160.195 Section... LABORATORY PRACTICE STANDARDS Records and Reports § 160.195 Retention of records. (a) Record retention...

  3. 46 CFR 195.35-20 - Spare charges.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Spare charges. 195.35-20 Section 195.35-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL CONTROL... recharge shall be carried for each self-contained breathing apparatus, and a complete set of spare...

  4. 13 CFR 120.195 - Disclosure of fees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Section 120.195 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Policies Applying to All Business Loans Reporting § 120.195 Disclosure of fees. An Applicant for a business loan... applicant obtain the loan, describing the services performed, and disclosing the amount of each fee paid or...

  5. 13 CFR 120.195 - Disclosure of fees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Section 120.195 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Policies Applying to All Business Loans Reporting § 120.195 Disclosure of fees. An Applicant for a business loan... applicant obtain the loan, describing the services performed, and disclosing the amount of each fee paid or...

  6. 13 CFR 120.195 - Disclosure of fees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Section 120.195 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Policies Applying to All Business Loans Reporting § 120.195 Disclosure of fees. An Applicant for a business loan... applicant obtain the loan, describing the services performed, and disclosing the amount of each fee paid or...

  7. 13 CFR 120.195 - Disclosure of fees.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Section 120.195 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Policies Applying to All Business Loans Reporting § 120.195 Disclosure of fees. An Applicant for a business loan... applicant obtain the loan, describing the services performed, and disclosing the amount of each fee paid or...

  8. 13 CFR 120.195 - Disclosure of fees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Section 120.195 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Policies Applying to All Business Loans Reporting § 120.195 Disclosure of fees. An Applicant for a business loan... applicant obtain the loan, describing the services performed, and disclosing the amount of each fee paid or...

  9. 12 CFR Appendix B to Part 195 - CRA Notice

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false CRA Notice B Appendix B to Part 195 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY COMMUNITY REINVESTMENT Pt. 195, App. B Appendix B to Part 195—CRA Notice (a) Notice for main offices and, if an interstate savings association...

  10. 49 CFR 195.3 - Incorporation by reference.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Fittings Industry, Inc. (MSS), 127 Park Street, NE., Vienna, VA 22180. 5. American Society for Testing and...)) §§ 195.205(b)(1); 195.432(b). (12) API Standard 1104, “Welding of Pipelines and Related Facilities” (20th....307(e). (7) 2007 ASME Boiler & Pressure Vessel Code, Section IX: “Qualification Standard for Welding...

  11. 15 CFR 922.195 - Permit procedures and criteria.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Permit procedures and criteria. 922.195 Section 922.195 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND COASTAL...

  12. 34 CFR 668.195 - Participation rate index appeals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Participation rate index appeals. 668.195 Section 668.195 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION STUDENT ASSISTANCE GENERAL PROVISIONS Two Year Cohort Default...

  13. Method of preparing high specific activity platinum-195m

    DOEpatents

    Mirzadeh, Saed; Du, Miting; Beets, Arnold L.; Knapp, Jr., Furn F.

    2004-06-15

    A method of preparing high-specific-activity .sup.195m Pt includes the steps of: exposing .sup.193 Ir to a flux of neutrons sufficient to convert a portion of the .sup.193 Ir to .sup.195m Pt to form an irradiated material; dissolving the irradiated material to form an intermediate solution comprising Ir and Pt; and separating the Pt from the Ir by cation exchange chromatography to produce .sup.195m Pt.

  14. 46 CFR 195.05-1 - Installation and details.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Installation and details. 195.05-1 Section 195.05-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL... Systems. Fire Detecting and Alarm Systems. Sound Powered Telephone and Voice Tube Systems. Engine Order...

  15. 46 CFR 195.05-1 - Installation and details.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Installation and details. 195.05-1 Section 195.05-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL... Systems. Fire Detecting and Alarm Systems. Sound Powered Telephone and Voice Tube Systems. Engine Order...

  16. 46 CFR 195.05-1 - Installation and details.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Installation and details. 195.05-1 Section 195.05-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL... Systems. Fire Detecting and Alarm Systems. Sound Powered Telephone and Voice Tube Systems. Engine Order...

  17. 46 CFR 195.05-1 - Installation and details.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Installation and details. 195.05-1 Section 195.05-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL... Systems. Fire Detecting and Alarm Systems. Sound Powered Telephone and Voice Tube Systems. Engine Order...

  18. 49 CFR 195.300 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.300 Scope. This subpart prescribes minimum requirements for the pressure...

  19. 49 CFR 195.300 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.300 Scope. This subpart prescribes minimum requirements for the pressure...

  20. 49 CFR 195.300 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.300 Scope. This subpart prescribes minimum requirements for the pressure...

  1. 49 CFR 195.300 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.300 Scope. This subpart prescribes minimum requirements for the pressure...

  2. 49 CFR 195.300 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.300 Scope. This subpart prescribes minimum requirements for the pressure...

  3. 21 CFR 1271.195 - Environmental control and monitoring.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Environmental control and monitoring. 1271.195 Section 1271.195 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) REGULATIONS UNDER CERTAIN OTHER ACTS ADMINISTERED BY THE FOOD AND DRUG ADMINISTRATION HUMAN CELLS...

  4. 21 CFR 133.195 - Swiss and emmentaler cheese.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Swiss and emmentaler cheese. 133.195 Section 133...) FOOD FOR HUMAN CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized Cheese and Related Products § 133.195 Swiss and emmentaler cheese. (a) Description. (1) Swiss cheese...

  5. 21 CFR 133.195 - Swiss and emmentaler cheese.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Swiss and emmentaler cheese. 133.195 Section 133...) FOOD FOR HUMAN CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized Cheese and Related Products § 133.195 Swiss and emmentaler cheese. (a) Description. (1) Swiss cheese...

  6. 46 CFR 108.195 - Location of accommodation spaces.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Location of accommodation spaces. 108.195 Section 108... DESIGN AND EQUIPMENT Construction and Arrangement Accommodation Spaces § 108.195 Location of accommodation spaces. (a) On surface type units, accommodation spaces must not be located forward of a vertical...

  7. 46 CFR 108.195 - Location of accommodation spaces.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Location of accommodation spaces. 108.195 Section 108... DESIGN AND EQUIPMENT Construction and Arrangement Accommodation Spaces § 108.195 Location of accommodation spaces. (a) On surface type units, accommodation spaces must not be located forward of a vertical...

  8. 46 CFR 108.195 - Location of accommodation spaces.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Location of accommodation spaces. 108.195 Section 108... DESIGN AND EQUIPMENT Construction and Arrangement Accommodation Spaces § 108.195 Location of accommodation spaces. (a) On surface type units, accommodation spaces must not be located forward of a vertical...

  9. 46 CFR 108.195 - Location of accommodation spaces.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Location of accommodation spaces. 108.195 Section 108... DESIGN AND EQUIPMENT Construction and Arrangement Accommodation Spaces § 108.195 Location of accommodation spaces. (a) On surface type units, accommodation spaces must not be located forward of a vertical...

  10. 46 CFR 108.195 - Location of accommodation spaces.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Location of accommodation spaces. 108.195 Section 108... DESIGN AND EQUIPMENT Construction and Arrangement Accommodation Spaces § 108.195 Location of accommodation spaces. (a) On surface type units, accommodation spaces must not be located forward of a vertical...

  11. 37 CFR 2.195 - Receipt of trademark correspondence.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... correspondence. 2.195 Section 2.195 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES General Information and Correspondence in... be given a filing date as of the date of deposit as “Express Mail” with the United States Postal...

  12. 27 CFR 1.95 - General.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... industrial use, unless such distilled spirits are shipped or delivered directly to the industrial user... of Distilled Spirits Sales of Distilled Spirits for Industrial Use § 1.95 General. Distillers...

  13. 46 CFR 174.195 - Bulkheads in machinery spaces.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Bulkheads in machinery spaces. 174.195 Section 174.195... in machinery spaces. (a) The bulkhead in each machinery space of each OSV must be watertight to the bulkhead deck. (b) Each penetration of, and each opening in, a bulkhead in a machinery space must— (1) Be...

  14. 46 CFR 174.195 - Bulkheads in machinery spaces.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Bulkheads in machinery spaces. 174.195 Section 174.195... in machinery spaces. (a) The bulkhead in each machinery space of each OSV must be watertight to the bulkhead deck. (b) Each penetration of, and each opening in, a bulkhead in a machinery space must— (1) Be...

  15. 46 CFR 174.195 - Bulkheads in machinery spaces.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Bulkheads in machinery spaces. 174.195 Section 174.195... in machinery spaces. (a) The bulkhead in each machinery space of each OSV must be watertight to the bulkhead deck. (b) Each penetration of, and each opening in, a bulkhead in a machinery space must— (1) Be...

  16. 46 CFR 174.195 - Bulkheads in machinery spaces.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Bulkheads in machinery spaces. 174.195 Section 174.195... in machinery spaces. (a) The bulkhead in each machinery space of each OSV must be watertight to the bulkhead deck. (b) Each penetration of, and each opening in, a bulkhead in a machinery space must— (1) Be...

  17. 46 CFR 174.195 - Bulkheads in machinery spaces.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Bulkheads in machinery spaces. 174.195 Section 174.195... in machinery spaces. (a) The bulkhead in each machinery space of each OSV must be watertight to the bulkhead deck. (b) Each penetration of, and each opening in, a bulkhead in a machinery space must— (1) Be...

  18. 40 CFR 195.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROFICIENCY PROGRAMS General Provisions § 195.2 Definitions. Definitions in 15 U.S.C. 2602 and 2662 apply to... exam means the exam which evaluates individuals who provide radon measurement services in a residential...

  19. 49 CFR 195.116 - Valves.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PIPELINE Design Requirements § 195.116 Valves. Each valve installed in a pipeline system must comply with the following: (a) The valve must be of a sound engineering design. (b) Materials subject to the...

  20. 49 CFR 195.5 - Conversion to service subject to this part.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Conversion to service subject to this part. 195.5 Section 195.5 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE General § 195.5 Conversion to service subject to this part. (a) A...

  1. 46 CFR 195.06-1 - Lifesaving appliances and arrangements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Lifesaving appliances and arrangements. 195.06-1 Section... VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Lifesaving Appliances and Arrangements § 195.06-1 Lifesaving appliances and arrangements. All lifesaving appliances and arrangements shall be...

  2. 46 CFR 195.11-15 - Plan approval and inspection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Plan approval and inspection. 195.11-15 Section 195.11-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS... and inspection. (a) Accommodation, power and chemical stores vans are subject to normal plan...

  3. 49 CFR 195.52 - Immediate notice of certain accidents.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Immediate notice of certain accidents. 195.52... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Annual, Accident, and Safety-Related Condition Reporting § 195.52 Immediate notice of certain accidents. (a) Notice requirements. At the earliest practicable moment following...

  4. 49 CFR 195.52 - Telephonic notice of certain accidents.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Telephonic notice of certain accidents. 195.52... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Annual, Accident, and Safety-Related Condition Reporting § 195.52 Telephonic notice of certain accidents. (a) At the earliest practicable moment following discovery of a...

  5. 46 CFR 195.30-15 - Self-contained breathing apparatus.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Self-contained breathing apparatus. 195.30-15 Section... VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Protection From Refrigerants § 195.30-15 Self-contained breathing apparatus. (a) Each vessel must have a self-contained breathing apparatus for...

  6. 46 CFR 195.30-15 - Self-contained breathing apparatus.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Self-contained breathing apparatus. 195.30-15 Section... VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Protection From Refrigerants § 195.30-15 Self-contained breathing apparatus. (a) Each vessel must have a self-contained breathing apparatus for...

  7. 49 CFR 195.555 - What are the qualifications for supervisors?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.555 What are the... that portion of the corrosion control procedures established under § 195.402(c)(3) for which they are...

  8. 49 CFR 195.555 - What are the qualifications for supervisors?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.555 What are the... that portion of the corrosion control procedures established under § 195.402(c)(3) for which they are...

  9. 49 CFR 195.555 - What are the qualifications for supervisors?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.555 What are the... that portion of the corrosion control procedures established under § 195.402(c)(3) for which they are...

  10. 49 CFR 195.555 - What are the qualifications for supervisors?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.555 What are the... that portion of the corrosion control procedures established under § 195.402(c)(3) for which they are...

  11. 49 CFR 195.555 - What are the qualifications for supervisors?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.555 What are the... that portion of the corrosion control procedures established under § 195.402(c)(3) for which they are...

  12. 49 CFR 195.256 - Crossing of railroads and highways.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Crossing of railroads and highways. 195.256... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.256 Crossing of railroads and highways. The pipe at each railroad or highway crossing must be installed so as to adequately withstand the dynamic...

  13. 49 CFR 195.256 - Crossing of railroads and highways.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Crossing of railroads and highways. 195.256... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.256 Crossing of railroads and highways. The pipe at each railroad or highway crossing must be installed so as to adequately withstand the dynamic...

  14. 49 CFR 195.256 - Crossing of railroads and highways.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Crossing of railroads and highways. 195.256... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.256 Crossing of railroads and highways. The pipe at each railroad or highway crossing must be installed so as to adequately withstand the dynamic...

  15. 49 CFR 195.256 - Crossing of railroads and highways.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Crossing of railroads and highways. 195.256... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.256 Crossing of railroads and highways. The pipe at each railroad or highway crossing must be installed so as to adequately withstand the dynamic...

  16. 49 CFR 195.256 - Crossing of railroads and highways.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Crossing of railroads and highways. 195.256... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.256 Crossing of railroads and highways. The pipe at each railroad or highway crossing must be installed so as to adequately withstand the dynamic...

  17. 46 CFR 195.11-20 - Marking and label plate.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Marking and label plate. 195.11-20 Section 195.11-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL... plate. (a) All vans shall be provided with a label plate stating light weight, gross weight, and power...

  18. 46 CFR 195.30-90 - Vessels contracted for before November 23, 1992.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Vessels contracted for before November 23, 1992. 195.30-90 Section 195.30-90 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Protection From Refrigerants § 195...

  19. 46 CFR 195.30-90 - Vessels contracted for before November 23, 1992.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Vessels contracted for before November 23, 1992. 195.30-90 Section 195.30-90 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS VESSEL CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Protection From Refrigerants § 195...

  20. 46 CFR 154.195 - Aluminum cargo tank: Steel enclosure.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Equipment Hull Structure § 154.195 Aluminum cargo tank: Steel enclosure. (a) An aluminum cargo tank and its dome must be enclosed by the vessel's hull structure or a separate steel cover. (b) The steel cover for... 46 Shipping 5 2012-10-01 2012-10-01 false Aluminum cargo tank: Steel enclosure. 154.195 Section...

  1. 46 CFR 154.195 - Aluminum cargo tank: Steel enclosure.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Equipment Hull Structure § 154.195 Aluminum cargo tank: Steel enclosure. (a) An aluminum cargo tank and its dome must be enclosed by the vessel's hull structure or a separate steel cover. (b) The steel cover for... 46 Shipping 5 2013-10-01 2013-10-01 false Aluminum cargo tank: Steel enclosure. 154.195 Section...

  2. 46 CFR 154.195 - Aluminum cargo tank: Steel enclosure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Equipment Hull Structure § 154.195 Aluminum cargo tank: Steel enclosure. (a) An aluminum cargo tank and its dome must be enclosed by the vessel's hull structure or a separate steel cover. (b) The steel cover for... 46 Shipping 5 2010-10-01 2010-10-01 false Aluminum cargo tank: Steel enclosure. 154.195 Section...

  3. 46 CFR 154.195 - Aluminum cargo tank: Steel enclosure.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Equipment Hull Structure § 154.195 Aluminum cargo tank: Steel enclosure. (a) An aluminum cargo tank and its dome must be enclosed by the vessel's hull structure or a separate steel cover. (b) The steel cover for... 46 Shipping 5 2014-10-01 2014-10-01 false Aluminum cargo tank: Steel enclosure. 154.195 Section...

  4. 46 CFR 154.195 - Aluminum cargo tank: Steel enclosure.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Equipment Hull Structure § 154.195 Aluminum cargo tank: Steel enclosure. (a) An aluminum cargo tank and its dome must be enclosed by the vessel's hull structure or a separate steel cover. (b) The steel cover for... 46 Shipping 5 2011-10-01 2011-10-01 false Aluminum cargo tank: Steel enclosure. 154.195 Section...

  5. MicroRNA-195 inhibits proliferation of cervical cancer cells by targeting cyclin D1a.

    PubMed

    Wang, Ning; Wei, Heng; Yin, Duo; Lu, Yanming; Zhang, Yao; Zhang, Qiao; Ma, Xiaoxin; Zhang, Shulan

    2016-04-01

    Cervical cancer is one of the most frequent gynecological malignancies in women worldwide. MicroRNA-195 (miR-195) was recently found highly expressed in cervical cancer. However, the role of miR-195 in the pathology of cervical cancer remains poorly understood. In this study, we first confirmed the downregulation of miR-195 in primary cervical cancer tissues. For the functional study, we introduced the sequences of miR-195 or miR-195 inhibitor into Hela and SiHa cervical cancer cell lines. Overexpression of miR-195 inhibited the proliferation of both Hela and SiHa cells. In contrast, reducing the endogenous miR-195 level by miR-195 inhibitor promoted the proliferation of cervical cancer cells. Flow cytometric assay showed that overexpression of miR-195 induced G1 phase arrest, whereas miR-195 inhibitor shortened G1 phase of cervical cancer cells. In addition, the suppressive role of miR-195 in cell cycle was also demonstrated by the western blot results of various cell cycle indicators, such as phosphorylated retinoblastoma (p-Rb) and proliferating cell nuclear antigen (PCNA), in the gain and loss of function experiments. Furthermore, Dual-Luciferase Reporter Assay revealed that miR-195 targeted the 3'-untranslated region of cyclin D1a transcript, such as to regulate cyclin D1 expression. In summary, our results suggest that miR-195 acts as a suppressor in the proliferation and cell cycle of cervical cancer cells by directly targeting cyclin D1a mRNA.

  6. Preclinical imaging characteristics and quantification of Platinum-195m SPECT.

    PubMed

    Aalbersberg, E A; de Wit-van der Veen, B J; Zwaagstra, O; Codée-van der Schilden, K; Vegt, E; Vogel, Wouter V

    2017-08-01

    In vivo biodistribution imaging of platinum-based compounds may allow better patient selection for treatment with chemo(radio)therapy. Radiolabeling with Platinum-195m ( 195m Pt) allows SPECT imaging, without altering the chemical structure or biological activity of the compound. We have assessed the feasibility of 195m Pt SPECT imaging in mice, with the aim to determine the image quality and accuracy of quantification for current preclinical imaging equipment. Enriched (>96%) 194 Pt was irradiated in the High Flux Reactor (HFR) in Petten, The Netherlands (NRG). A 0.05 M HCl 195m Pt-solution with a specific activity of 33 MBq/mg was obtained. Image quality was assessed for the NanoSPECT/CT (Bioscan Inc., Washington DC, USA) and U-SPECT + /CT (MILabs BV, Utrecht, the Netherlands) scanners. A radioactivity-filled rod phantom (rod diameter 0.85-1.7 mm) filled with 1 MBq 195m Pt was scanned with different acquisition durations (10-120 min). Four healthy mice were injected intravenously with 3-4 MBq 195m Pt. Mouse images were acquired with the NanoSPECT for 120 min at 0, 2, 4, or 24 h after injection. Organs were delineated to quantify 195m Pt concentrations. Immediately after scanning, the mice were sacrificed, and the platinum concentration was determined in organs using a gamma counter and graphite furnace - atomic absorption spectroscopy (GF-AAS) as reference standards. A 30-min acquisition of the phantom provided visually adequate image quality for both scanners. The smallest visible rods were 0.95 mm in diameter on the NanoSPECT and 0.85 mm in diameter on the U-SPECT + . The image quality in mice was visually adequate. Uptake was seen in the kidneys with excretion to the bladder, and in the liver, blood, and intestine. No uptake was seen in the brain. The Spearman correlation between SPECT and gamma counter was 0.92, between SPECT and GF-AAS it was 0.84, and between GF-AAS and gamma counter it was0.97 (all p < 0.0001). Preclinical 195m Pt SPECT is

  7. 49 CFR 195.310 - Records.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.310 Records. (a) A record must be made of each pressure test required by... use. (b) The record required by paragraph (a) of this section must include: (1) The pressure recording...

  8. 49 CFR 195.310 - Records.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.310 Records. (a) A record must be made of each pressure test required by... use. (b) The record required by paragraph (a) of this section must include: (1) The pressure recording...

  9. 41 CFR 102-85.195 - Does GSA provide special services?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Does GSA provide special services? 102-85.195 Section 102-85.195 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 85-PRICING POLICY FOR...

  10. 27 CFR 19.5 - Manufacturing products unfit for beverage use.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... qualify as a distilled spirits plant (processor): (1) Medicines, medicinal preparations, food products... beverage purposes; (3) Toilet, medicinal, and antiseptic preparations and solutions that are unfit for use... unfit for beverage use. 19.5 Section 19.5 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX...

  11. 49 CFR 195.557 - Which pipelines must have coating for external corrosion control?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... corrosion control? 195.557 Section 195.557 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.557 Which pipelines must have coating for external corrosion control? Except bottoms of aboveground breakout tanks, each...

  12. 49 CFR 195.557 - Which pipelines must have coating for external corrosion control?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... corrosion control? 195.557 Section 195.557 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.557 Which pipelines must have coating for external corrosion control? Except bottoms of aboveground breakout tanks, each...

  13. 49 CFR 195.557 - Which pipelines must have coating for external corrosion control?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... corrosion control? 195.557 Section 195.557 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.557 Which pipelines must have coating for external corrosion control? Except bottoms of aboveground breakout tanks, each...

  14. 49 CFR 195.557 - Which pipelines must have coating for external corrosion control?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... corrosion control? 195.557 Section 195.557 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.557 Which pipelines must have coating for external corrosion control? Except bottoms of aboveground breakout tanks, each...

  15. 49 CFR 195.557 - Which pipelines must have coating for external corrosion control?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... corrosion control? 195.557 Section 195.557 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.557 Which pipelines must have coating for external corrosion control? Except bottoms of aboveground breakout tanks, each...

  16. BDNF-mediates Down-regulation of MicroRNA-195 Inhibits Ischemic Cardiac Apoptosis in Rats

    PubMed Central

    Hang, Pengzhou; Sun, Chuan; Guo, Jing; Zhao, Jing; Du, Zhimin

    2016-01-01

    Background: Our previous studies suggested that brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) axis inhibited cardiomyocyte apoptosis in myocardial infarction (MI). However, the relationship between BDNF and microRNA (miRNA) in cardiomyocytes are unclear. The present study was performed to investigate the role of miR-195 and the interplay between BDNF and miR-195 in ischemic cardiomyocyte apoptosis. Methods: Male Wistar rats were subjected to coronary artery ligation, and primary neonatal rat ventricular myocytes were treated with hypoxia or hydrogen peroxide (H2O2). BDNF level in rat ventricles was measured by enzyme linked immunosorbent assay (ELISA). miR-195 mimic, inhibitor or negative control was transfected into the cardiomyocytes. Cell viability and apoptosis were detected by MTT assay and TdT-mediated dUTP nick end labeling (TUNEL) staining, respectively. Cardiac function and apoptosis were detected in MI rats intravenously injected with antagomiR-195. Luciferase assay, Western blot and Real-time RT-PCR were employed to clarify the interplay between miR-195 and BDNF. Results: miR-195 level was dynamically regulated in response to MI and significantly increased in ischemic regions 24 h post-MI as well as in hypoxic or H2O2-treated cardiomyocytes. Meanwhile, BDNF protein level was rapidly increased in MI rats and H2O2-treated cardiomyocytes. Apoptosis in both hypoxic and H2O2-treated cardiomyocytes were markedly reduced and cell viability was increased by miR-195 inhibitor. Moreover, inhibition of miR-195 significantly improved cardiac function of MI rats. Bcl-2 but not BDNF was validated as the direct target of miR-195. Furthermore, BDNF abolished the pro-apoptotic role of miR-195, which was reversed by its scavenger TrkB-Fc. Conclusion: Up-regulation of miR-195 in ischemic cardiomyocytes promotes ischemic apoptosis by targeting Bcl-2. BDNF mitigated the pro-apoptotic effect of miR-195 in rat cardiomyocytes. These findings may

  17. 46 CFR 195.35-5 - General.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 1014 (incorporated by reference, see § 195.01-3). (d) All lifelines shall be of steel or bronze wire rope. Steel wire rope shall be either inherently corrosion-resistant, or made so by galvanizing or...

  18. 46 CFR 195.35-5 - General.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 1014 (incorporated by reference, see § 195.01-3). (d) All lifelines shall be of steel or bronze wire rope. Steel wire rope shall be either inherently corrosion-resistant, or made so by galvanizing or...

  19. 49 CFR 195.563 - Which pipelines must have cathodic protection?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Which pipelines must have cathodic protection? 195... have cathodic protection? (a) Each buried or submerged pipeline that is constructed, relocated, replaced, or otherwise changed after the applicable date in § 195.401(c) must have cathodic protection. The...

  20. 49 CFR 195.563 - Which pipelines must have cathodic protection?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Which pipelines must have cathodic protection? 195... have cathodic protection? (a) Each buried or submerged pipeline that is constructed, relocated, replaced, or otherwise changed after the applicable date in § 195.401(c) must have cathodic protection. The...

  1. 12 CFR 195.12 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... with § 195.41. (d) Automated teller machine (ATM) means an automated, unstaffed banking facility owned...) Motor vehicle loan, which is a consumer loan extended for the purchase of and secured by a motor vehicle... means a savings association that offers only a narrow product line (such as credit card or motor vehicle...

  2. 12 CFR 195.12 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... with § 195.41. (d) Automated teller machine (ATM) means an automated, unstaffed banking facility owned...) Motor vehicle loan, which is a consumer loan extended for the purchase of and secured by a motor vehicle... means a savings association that offers only a narrow product line (such as credit card or motor vehicle...

  3. 12 CFR 195.12 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... with § 195.41. (d) Automated teller machine (ATM) means an automated, unstaffed banking facility owned...) Motor vehicle loan, which is a consumer loan extended for the purchase of and secured by a motor vehicle... means a savings association that offers only a narrow product line (such as credit card or motor vehicle...

  4. 49 CFR 195.266 - Construction records.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... rejected weld. (b) The amount, location; and cover of each size of pipe installed. (c) The location of each... overhead crossing. (f) The location of each valve and corrosion test station. [Amdt. 195-22, 46 FR 38360...

  5. 45 CFR 286.195 - What penalties will apply to Tribes?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 2 2012-10-01 2012-10-01 false What penalties will apply to Tribes? 286.195... TRIBAL TANF PROVISIONS Accountability and Penalties § 286.195 What penalties will apply to Tribes? (a) Tribes will be subject to fiscal penalties and requirements as follows: (1) If we determine that a Tribe...

  6. 45 CFR 286.195 - What penalties will apply to Tribes?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false What penalties will apply to Tribes? 286.195... TRIBAL TANF PROVISIONS Accountability and Penalties § 286.195 What penalties will apply to Tribes? (a) Tribes will be subject to fiscal penalties and requirements as follows: (1) If we determine that a Tribe...

  7. 45 CFR 286.195 - What penalties will apply to Tribes?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 2 2013-10-01 2012-10-01 true What penalties will apply to Tribes? 286.195... TRIBAL TANF PROVISIONS Accountability and Penalties § 286.195 What penalties will apply to Tribes? (a) Tribes will be subject to fiscal penalties and requirements as follows: (1) If we determine that a Tribe...

  8. 45 CFR 286.195 - What penalties will apply to Tribes?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true What penalties will apply to Tribes? 286.195... TRIBAL TANF PROVISIONS Accountability and Penalties § 286.195 What penalties will apply to Tribes? (a) Tribes will be subject to fiscal penalties and requirements as follows: (1) If we determine that a Tribe...

  9. 49 CFR 195.302 - General requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... without pressure testing under this subpart: (1) Any hazardous liquid pipeline whose maximum operating... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.302 General requirements. (a) Except as otherwise provided in this section...

  10. 49 CFR 195.302 - General requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... without pressure testing under this subpart: (1) Any hazardous liquid pipeline whose maximum operating... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.302 General requirements. (a) Except as otherwise provided in this section...

  11. 49 CFR 195.302 - General requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... without pressure testing under this subpart: (1) Any hazardous liquid pipeline whose maximum operating... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.302 General requirements. (a) Except as otherwise provided in this section...

  12. 49 CFR 195.302 - General requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... without pressure testing under this subpart: (1) Any hazardous liquid pipeline whose maximum operating... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.302 General requirements. (a) Except as otherwise provided in this section...

  13. 49 CFR 195.302 - General requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... without pressure testing under this subpart: (1) Any hazardous liquid pipeline whose maximum operating... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.302 General requirements. (a) Except as otherwise provided in this section...

  14. 49 CFR 195.559 - What coating material may I use for external corrosion control?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... corrosion control? 195.559 Section 195.559 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.559 What coating material may I use for external corrosion control? Coating material for external corrosion control under...

  15. 49 CFR 195.559 - What coating material may I use for external corrosion control?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... corrosion control? 195.559 Section 195.559 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.559 What coating material may I use for external corrosion control? Coating material for external corrosion control under...

  16. 49 CFR 195.559 - What coating material may I use for external corrosion control?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... corrosion control? 195.559 Section 195.559 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.559 What coating material may I use for external corrosion control? Coating material for external corrosion control under...

  17. 49 CFR 195.559 - What coating material may I use for external corrosion control?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... corrosion control? 195.559 Section 195.559 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.559 What coating material may I use for external corrosion control? Coating material for external corrosion control under...

  18. 49 CFR 195.559 - What coating material may I use for external corrosion control?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... corrosion control? 195.559 Section 195.559 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.559 What coating material may I use for external corrosion control? Coating material for external corrosion control under...

  19. Correlation between some parameters of lead absorption and lead intoxication

    PubMed Central

    Waldron, H. A.

    1971-01-01

    Waldron, H. A. (1971).Brit. J. industr. Med.,28, 195-199. Correlation between some parameters of lead absorption and lead intoxication. Use has been made of data collected over a number of years from workers exposed to a lead hazard in a motor-car factory. The correlations between various parameters of lead absorption and lead intoxication were computed, including blood and urine lead concentrations, urinary coproporphyrin, ALA and PBG concentrations, and haemoglobin concentration. In all, 15 correlation coefficients were calculated, of which only six showed a statistically significant result (i.e., P<0·05). These six were blood lead and urine lead (r = 0·38, P<0·001), urine lead and coproporphyrin (r = 0·42, P<0·001), urine lead and ALA (r = 0·43, P<0·001), coproporphyrin and ALA (r = 0·75, P<0·001), ALA and PBG (r = 0·49, P<0·001), and urine lead and PBG (r = 0·19, P<0·05). PMID:5572689

  20. 49 CFR 195.440 - Public awareness.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Petroleum Institute's (API) Recommended Practice (RP) 1162 (incorporated by reference, see § 195.3). (b) The operator's program must follow the general program recommendations of API RP 1162 and assess the unique... general program recommendations, including baseline and supplemental requirements of API RP 1162, unless...

  1. 49 CFR 195.440 - Public awareness.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Petroleum Institute's (API) Recommended Practice (RP) 1162 (incorporated by reference, see § 195.3). (b) The operator's program must follow the general program recommendations of API RP 1162 and assess the unique... general program recommendations, including baseline and supplemental requirements of API RP 1162, unless...

  2. 49 CFR 195.440 - Public awareness.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Petroleum Institute's (API) Recommended Practice (RP) 1162 (incorporated by reference, see § 195.3). (b) The operator's program must follow the general program recommendations of API RP 1162 and assess the unique... general program recommendations, including baseline and supplemental requirements of API RP 1162, unless...

  3. 42 CFR 416.195 - Determination of membership in new classes of new technology IOLs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... technology IOLs. 416.195 Section 416.195 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT... Adjustment in Payment Amounts for New Technology Intraocular Lenses Furnished by Ambulatory Service Centers § 416.195 Determination of membership in new classes of new technology IOLs. (a) Factors to be...

  4. 42 CFR 416.195 - Determination of membership in new classes of new technology IOLs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... technology IOLs. 416.195 Section 416.195 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT... Adjustment in Payment Amounts for New Technology Intraocular Lenses Furnished by Ambulatory Service Centers § 416.195 Determination of membership in new classes of new technology IOLs. (a) Factors to be...

  5. 46 CFR 195.07-5 - Ocean, coastwise, or Great Lakes service.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Ocean, coastwise, or Great Lakes service. 195.07-5 Section 195.07-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Ocean, coastwise, or Great Lakes service. (a) Vessels in ocean, coastwise, or Great Lakes service shall...

  6. 46 CFR 195.07-5 - Ocean, coastwise, or Great Lakes service.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Ocean, coastwise, or Great Lakes service. 195.07-5 Section 195.07-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Ocean, coastwise, or Great Lakes service. (a) Vessels in ocean, coastwise, or Great Lakes service shall...

  7. 46 CFR 195.07-5 - Ocean, coastwise, or Great Lakes service.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Ocean, coastwise, or Great Lakes service. 195.07-5 Section 195.07-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Ocean, coastwise, or Great Lakes service. (a) Vessels in ocean, coastwise, or Great Lakes service shall...

  8. 46 CFR 195.07-5 - Ocean, coastwise, or Great Lakes service.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Ocean, coastwise, or Great Lakes service. 195.07-5 Section 195.07-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Ocean, coastwise, or Great Lakes service. (a) Vessels in ocean, coastwise, or Great Lakes service shall...

  9. 46 CFR 195.07-5 - Ocean, coastwise, or Great Lakes service.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Ocean, coastwise, or Great Lakes service. 195.07-5 Section 195.07-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Ocean, coastwise, or Great Lakes service. (a) Vessels in ocean, coastwise, or Great Lakes service shall...

  10. 12 CFR 195.27 - Strategic plan.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Assessing Performance § 195.27 Strategic plan. (a) Alternative election. The appropriate Federal banking... under an approved plan for at least one year. (b) Data reporting. The appropriate Federal banking agency... any multi-year plan must include annual interim measurable goals under which the appropriate Federal...

  11. 12 CFR 195.27 - Strategic plan.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Assessing Performance § 195.27 Strategic plan. (a) Alternative election. The appropriate Federal banking... under an approved plan for at least one year. (b) Data reporting. The appropriate Federal banking agency... any multi-year plan must include annual interim measurable goals under which the appropriate Federal...

  12. 12 CFR 195.27 - Strategic plan.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Assessing Performance § 195.27 Strategic plan. (a) Alternative election. The appropriate Federal banking... under an approved plan for at least one year. (b) Data reporting. The appropriate Federal banking agency... any multi-year plan must include annual interim measurable goals under which the appropriate Federal...

  13. 42 CFR 416.195 - Determination of membership in new classes of new technology IOLs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... technology IOLs. 416.195 Section 416.195 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT... Payment Amounts for New Technology Intraocular Lenses Furnished by Ambulatory Service Centers § 416.195 Determination of membership in new classes of new technology IOLs. (a) Factors to be considered. CMS uses the...

  14. 41 CFR 102-117.195 - Are there time limits affecting filing of a claim?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Are there time limits affecting filing of a claim? 102-117.195 Section 102-117.195 Public Contracts and Property Management... 117-TRANSPORTATION MANAGEMENT Shipping Freight § 102-117.195 Are there time limits affecting filing of...

  15. 49 CFR 195.262 - Pumping equipment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... PIPELINE Construction § 195.262 Pumping equipment. (a) Adequate ventilation must be provided in pump... provided in each pump station: (1) Safety devices that prevent overpressuring of pumping equipment..., pumping equipment must be installed on property that is under the control of the operator and at least 15...

  16. 49 CFR 195.262 - Pumping equipment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... PIPELINE Construction § 195.262 Pumping equipment. (a) Adequate ventilation must be provided in pump... provided in each pump station: (1) Safety devices that prevent overpressuring of pumping equipment..., pumping equipment must be installed on property that is under the control of the operator and at least 15...

  17. 49 CFR 195.262 - Pumping equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PIPELINE Construction § 195.262 Pumping equipment. (a) Adequate ventilation must be provided in pump... provided in each pump station: (1) Safety devices that prevent overpressuring of pumping equipment..., pumping equipment must be installed on property that is under the control of the operator and at least 15...

  18. 49 CFR 195.262 - Pumping equipment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... PIPELINE Construction § 195.262 Pumping equipment. (a) Adequate ventilation must be provided in pump... provided in each pump station: (1) Safety devices that prevent overpressuring of pumping equipment..., pumping equipment must be installed on property that is under the control of the operator and at least 15...

  19. 49 CFR 195.505 - Qualification program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... that the individual's performance of a covered task contributed to an accident as defined in Part 195... tasks; (b) Ensure through evaluation that individuals performing covered tasks are qualified; (c) Allow individuals that are not qualified pursuant to this subpart to perform a covered task if directed and observed...

  20. 28 CFR 19.5 - Report to the Office of Juvenile Justice and Delinquency Prevention.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Report to the Office of Juvenile Justice and Delinquency Prevention. 19.5 Section 19.5 Judicial Administration DEPARTMENT OF JUSTICE USE OF PENALTY MAIL IN THE LOCATION AND RECOVERY OF MISSING CHILDREN § 19.5 Report to the Office of Juvenile...

  1. 28 CFR 19.5 - Report to the Office of Juvenile Justice and Delinquency Prevention.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Report to the Office of Juvenile Justice and Delinquency Prevention. 19.5 Section 19.5 Judicial Administration DEPARTMENT OF JUSTICE USE OF PENALTY MAIL IN THE LOCATION AND RECOVERY OF MISSING CHILDREN § 19.5 Report to the Office of Juvenile...

  2. 28 CFR 19.5 - Report to the Office of Juvenile Justice and Delinquency Prevention.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Report to the Office of Juvenile Justice and Delinquency Prevention. 19.5 Section 19.5 Judicial Administration DEPARTMENT OF JUSTICE USE OF PENALTY MAIL IN THE LOCATION AND RECOVERY OF MISSING CHILDREN § 19.5 Report to the Office of Juvenile...

  3. 28 CFR 19.5 - Report to the Office of Juvenile Justice and Delinquency Prevention.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Report to the Office of Juvenile Justice and Delinquency Prevention. 19.5 Section 19.5 Judicial Administration DEPARTMENT OF JUSTICE USE OF PENALTY MAIL IN THE LOCATION AND RECOVERY OF MISSING CHILDREN § 19.5 Report to the Office of Juvenile...

  4. Integrated analysis identifies microRNA-195 as a suppressor of Hippo-YAP pathway in colorectal cancer.

    PubMed

    Sun, Min; Song, Haibin; Wang, Shuyi; Zhang, Chunxiao; Zheng, Liang; Chen, Fangfang; Shi, Dongdong; Chen, Yuanyuan; Yang, Chaogang; Xiang, Zhenxian; Liu, Qing; Wei, Chen; Xiong, Bin

    2017-03-29

    With persistent inconsistencies in colorectal cancer (CRC) miRNAs expression data, it is crucial to shift toward inclusion of a "pre-laboratory" integrated analysis to expedite effective precision medicine and translational research. Aberrant expression of hsa-miRNA-195 (miR-195) which is distinguished as a clinically noteworthy miRNA has previously been observed in multiple cancers, yet its role in CRC remains unclear. In this study, we performed an integrated analysis of seven CRC miRNAs expression datasets. The expression of miR-195 was validated in The Cancer Genome Atlas (TCGA) datasets, and an independent validation sample cohort. Colon cancer cells were transfected with miR-195 mimic and inhibitor, after which cell proliferation, colony formation, migration, invasion, and dual luciferase reporter were assayed. Xenograft mouse models were used to determine the role of miR-195 in CRC tumorigenicity in vivo. Four downregulated miRNAs (hsa-let-7a, hsa-miR-125b, hsa-miR-145, and hsa-miR-195) were demonstrated to be potentially useful diagnostic markers in the clinical setting. CRC patients with a decreased level of miR-195-5p in tumor tissues had significantly shortened survival as revealed by the TCGA colon adenocarcinoma (COAD) dataset and our CRC cohort. Overexpression of miR-195-5p in DLD1 and HCT116 cells repressed cell growth, colony formation, invasion, and migration. Inhibition of miR-195-5p function contributed to aberrant cell proliferation, migration, invasion, and epithelial mesenchymal transition (EMT). We identified miR-195-5p binding sites within the 3'-untranslated region (3'-UTR) of the human yes-associated protein (YAP) mRNA. YAP1 expression was downregulated after miR-195-5p treatment by qRT-PCR analysis and western blot. Four downregulated miRNAs were shown to be prime candidates for a panel of biomarkers with sufficient diagnostic accuracy for CRC in a clinical setting. Our integrated microRNA profiling approach identified miR-195-5p

  5. 46 CFR 195.35-5 - General.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 1014 (incorporated by reference, see § 195.01-3). (d) All lifelines shall be of steel or bronze wire rope. Steel wire rope shall be either inherently corrosion-resistant, or made so by galvanizing or... breaking strength of 1,500 pounds. (e) All equipment shall be maintained in an operative condition, and it...

  6. 46 CFR 195.35-5 - General.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 1014 (incorporated by reference, see § 195.01-3). (d) All lifelines shall be of steel or bronze wire rope. Steel wire rope shall be either inherently corrosion-resistant, or made so by galvanizing or... breaking strength of 1,500 pounds. (e) All equipment shall be maintained in an operative condition, and it...

  7. 46 CFR 195.35-5 - General.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 1014 (incorporated by reference, see § 195.01-3). (d) All lifelines shall be of steel or bronze wire rope. Steel wire rope shall be either inherently corrosion-resistant, or made so by galvanizing or... breaking strength of 1,500 pounds. (e) All equipment shall be maintained in an operative condition, and it...

  8. γT -S195A thrombin reduces the anticoagulant effects of dabigatran in vitro and in vivo.

    PubMed

    Sheffield, W P; Lambourne, M D; Eltringham-Smith, L J; Bhakta, V; Arnold, D M; Crowther, M A

    2014-07-01

    Dabigatran etexilate (DE) is an oral direct thrombin inhibitor used to prevent strokes in patients with atrial fibrillation. No licensed DE antidote is currently available. We hypothesized that active site-mutated S195A thrombin (S195A-IIa) and/or its trypsinized derivative (γT -S195A-IIa) would sequester dabigatran, the active form of DE, and reduce its anticoagulant effects. To assess active site-mutated S195A or γT -S195A-IIa as dabigatran reversal agents in vitro and in vivo. Diluted thrombin time (dTT) assays were performed using human or murine plasma containing dabigatran, combined with S195A-IIa, γT -S195A-IIa or FPR-chloromethyl ketone-treated thrombin (FPR-IIa). Bleeding times were determined in anesthetized DE-treated mice also receiving γT -S195A-IIa or vehicle 15 min prior to tail transection. The time to occlusion of carotid arteries of DE-treated mice also receiving S195A-IIa, γT -S195A-IIa, prothrombin complex concentrate (PCC) or vehicle, 15 min prior to topical FeCl3 , was determined using Doppler ultrasound. γT-S195A-IIa reduced dTT values of dabigatran-containing human and murine plasma more effectively than S195-IIa; FPR-IIa had no effect. A dose of 13 mg kg(-1) DE abrogated occlusive thrombus formation in the carotid arteries of FeCl3 -treated mice; γT -S195A-IIa (6 mg kg(-1) ) or PCC (14.3 IU kg(-1) ), but not saline vehicle or S195A-IIa (6 mg kg(-1) ), was equally effective in restoring thrombus formation. Bleeding times of mice treated with 60 mg kg(-1) DE and γT -S195A-IIa (6 mg kg(-1) ) or saline vehicle did not differ. Our data suggest that γT -S195A-IIa decreases the anticoagulant effects of dabigatran in vitro and is partially effective at restoring hemostasis-related thrombus formation in DE-treated mice in vivo. © 2014 International Society on Thrombosis and Haemostasis.

  9. 49 CFR 195.561 - When must I inspect pipe coating used for external corrosion control?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... corrosion control? 195.561 Section 195.561 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.561 When must I inspect pipe coating used for external corrosion control? (a) You must inspect all external pipe coating...

  10. 49 CFR 195.561 - When must I inspect pipe coating used for external corrosion control?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... corrosion control? 195.561 Section 195.561 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.561 When must I inspect pipe coating used for external corrosion control? (a) You must inspect all external pipe coating...

  11. 49 CFR 195.561 - When must I inspect pipe coating used for external corrosion control?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... corrosion control? 195.561 Section 195.561 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.561 When must I inspect pipe coating used for external corrosion control? (a) You must inspect all external pipe coating...

  12. 49 CFR 195.561 - When must I inspect pipe coating used for external corrosion control?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... corrosion control? 195.561 Section 195.561 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.561 When must I inspect pipe coating used for external corrosion control? (a) You must inspect all external pipe coating...

  13. 49 CFR 195.561 - When must I inspect pipe coating used for external corrosion control?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... corrosion control? 195.561 Section 195.561 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.561 When must I inspect pipe coating used for external corrosion control? (a) You must inspect all external pipe coating...

  14. 49 CFR 195.134 - CPM leak detection.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... system must comply with section 4.2 of API 1130 in its design and with any other design criteria addressed in API 1130 for components of the CPM leak detection system. [Amdt. 195-62, 63 FR 36376, July 6...

  15. 49 CFR 195.134 - CPM leak detection.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... system must comply with section 4.2 of API 1130 in its design and with any other design criteria addressed in API 1130 for components of the CPM leak detection system. [Amdt. 195-62, 63 FR 36376, July 6...

  16. 49 CFR 195.134 - CPM leak detection.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... system must comply with section 4.2 of API 1130 in its design and with any other design criteria addressed in API 1130 for components of the CPM leak detection system. [Amdt. 195-62, 63 FR 36376, July 6...

  17. 49 CFR 195.134 - CPM leak detection.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... system must comply with section 4.2 of API 1130 in its design and with any other design criteria addressed in API 1130 for components of the CPM leak detection system. [Amdt. 195-62, 63 FR 36376, July 6...

  18. 49 CFR 195.134 - CPM leak detection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... system must comply with section 4.2 of API 1130 in its design and with any other design criteria addressed in API 1130 for components of the CPM leak detection system. [Amdt. 195-62, 63 FR 36376, July 6...

  19. 9 CFR 381.195 - Definitions; requirements for importation into the United States.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Definitions; requirements for importation into the United States. 381.195 Section 381.195 Animals and Animal Products FOOD SAFETY AND...

  20. 9 CFR 381.195 - Definitions; requirements for importation into the United States.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... importation into the United States. 381.195 Section 381.195 Animals and Animal Products FOOD SAFETY AND... thereof, shall be imported into the United States unless they are healthful, wholesome, fit for human food, not adulterated, and contain no dye, chemical, preservative, or ingredient which renders them...

  1. 9 CFR 381.195 - Definitions; requirements for importation into the United States.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... importation into the United States. 381.195 Section 381.195 Animals and Animal Products FOOD SAFETY AND... thereof, shall be imported into the United States unless they are healthful, wholesome, fit for human food, not adulterated, and contain no dye, chemical, preservative, or ingredient which renders them...

  2. 9 CFR 381.195 - Definitions; requirements for importation into the United States.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... importation into the United States. 381.195 Section 381.195 Animals and Animal Products FOOD SAFETY AND... thereof, shall be imported into the United States unless they are healthful, wholesome, fit for human food, not adulterated, and contain no dye, chemical, preservative, or ingredient which renders them...

  3. 9 CFR 381.195 - Definitions; requirements for importation into the United States.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... importation into the United States. 381.195 Section 381.195 Animals and Animal Products FOOD SAFETY AND... thereof, shall be imported into the United States unless they are healthful, wholesome, fit for human food, not adulterated, and contain no dye, chemical, preservative, or ingredient which renders them...

  4. 30 CFR 250.195 - What notification does MMS require on the production status of wells?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the well in a production status. You must confirm oral notification by telefax or e-mail within those... production status of wells? 250.195 Section 250.195 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT... Information and Reporting Requirements § 250.195 What notification does MMS require on the production status...

  5. 49 CFR 195.260 - Valves: Location.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... off the lateral without interrupting the flow in the trunk line. (e) On each side of a water crossing that is more than 100 feet (30 meters) wide from high-water mark to high-water mark unless the... water for human consumption. [Amdt. 195-22, 46 FR 38360, July 27, 1981; 47 FR 32721, July 29, 1982; Amdt...

  6. 49 CFR 195.551 - What do the regulations in this subpart cover?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false What do the regulations in this subpart cover? 195... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.551 What do the regulations in this subpart cover? This subpart prescribes minimum requirements for protecting steel pipelines...

  7. 40 CFR 195.1 - Purpose and applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PROGRAMS RADON PROFICIENCY PROGRAMS General Provisions § 195.1 Purpose and applicability. (a) Purpose. The... following programs: The National Radon Measurement Proficiency (RMP) Program, the individual proficiency component of the RMP Program, and the National Radon Contractor Proficiency (RCP) Program. (b) Applicability...

  8. 40 CFR 195.1 - Purpose and applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROGRAMS RADON PROFICIENCY PROGRAMS General Provisions § 195.1 Purpose and applicability. (a) Purpose. The... following programs: The National Radon Measurement Proficiency (RMP) Program, the individual proficiency component of the RMP Program, and the National Radon Contractor Proficiency (RCP) Program. (b) Applicability...

  9. 49 CFR 195.587 - What methods are available to determine the strength of corroded pipe?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... strength of corroded pipe? 195.587 Section 195.587 Transportation Other Regulations Relating to... methods are available to determine the strength of corroded pipe? Under § 195.585, you may use the procedure in ASME B31G, “Manual for Determining the Remaining Strength of Corroded Pipelines,” or the...

  10. 49 CFR 195.587 - What methods are available to determine the strength of corroded pipe?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... strength of corroded pipe? 195.587 Section 195.587 Transportation Other Regulations Relating to... methods are available to determine the strength of corroded pipe? Under § 195.585, you may use the procedure in ASME B31G, “Manual for Determining the Remaining Strength of Corroded Pipelines,” or the...

  11. 49 CFR 195.308 - Testing of tie-ins.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.308 Testing of tie-ins. Pipe associated with tie-ins must be pressure...

  12. 49 CFR 195.308 - Testing of tie-ins.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.308 Testing of tie-ins. Pipe associated with tie-ins must be pressure...

  13. 49 CFR 195.308 - Testing of tie-ins.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.308 Testing of tie-ins. Pipe associated with tie-ins must be pressure...

  14. 49 CFR 195.308 - Testing of tie-ins.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.308 Testing of tie-ins. Pipe associated with tie-ins must be pressure...

  15. 49 CFR 195.308 - Testing of tie-ins.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.308 Testing of tie-ins. Pipe associated with tie-ins must be pressure...

  16. MicroRNA-195 prevents dendritic degeneration and neuron death in rats following chronic brain hypoperfusion

    PubMed Central

    Chen, Xin; Jiang, Xue-Mei; Zhao, Lin-Jing; Sun, Lin-Lin; Yan, Mei-Ling; Tian, You; Zhang, Shuai; Duan, Ming-Jing; Zhao, Hong-Mei; Li, Wen-Rui; Hao, Yang-Yang; Wang, Li-Bo; Xiong, Qiao-Jie; Ai, Jing

    2017-01-01

    Impaired synaptic plasticity and neuron loss are hallmarks of Alzheimer’s disease and vascular dementia. Here, we found that chronic brain hypoperfusion (CBH) by bilateral common carotid artery occlusion (2VO) decreased the total length, numbers and crossings of dendrites and caused neuron death in rat hippocampi and cortices. It also led to increase in N-terminal β-amyloid precursor protein (N-APP) and death receptor-6 (DR6) protein levels and in the activation of caspase-3 and caspase-6. Further study showed that DR6 protein was downregulated by miR-195 overexpression, upregulated by miR-195 inhibition, and unchanged by binding-site mutation and miR-masks. Knockdown of endogenous miR-195 by lentiviral vector-mediated overexpression of its antisense molecule (lenti-pre-AMO-miR-195) decreased the total length, numbers and crossings of dendrites and neuron death, upregulated N-APP and DR6 levels, and elevated cleaved caspase-3 and caspase-6 levels. Overexpression of miR-195 using lenti-pre-miR-195 prevented these changes triggered by 2VO. We conclude that miR-195 is involved in CBH-induced dendritic degeneration and neuron death through activation of the N-APP/DR6/caspase pathway. PMID:28569780

  17. 46 CFR 195.07-10 - Lakes, bays, and sounds, or river service.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Lakes, bays, and sounds, or river service. 195.07-10 Section 195.07-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Lakes, bays, and sounds, or river service. (a) Vessels in lakes, bays, and sounds, or river service...

  18. 46 CFR 195.07-10 - Lakes, bays, and sounds, or river service.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Lakes, bays, and sounds, or river service. 195.07-10 Section 195.07-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Lakes, bays, and sounds, or river service. (a) Vessels in lakes, bays, and sounds, or river service...

  19. 46 CFR 195.07-10 - Lakes, bays, and sounds, or river service.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Lakes, bays, and sounds, or river service. 195.07-10 Section 195.07-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Lakes, bays, and sounds, or river service. (a) Vessels in lakes, bays, and sounds, or river service...

  20. 46 CFR 195.07-10 - Lakes, bays, and sounds, or river service.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Lakes, bays, and sounds, or river service. 195.07-10 Section 195.07-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Lakes, bays, and sounds, or river service. (a) Vessels in lakes, bays, and sounds, or river service...

  1. 46 CFR 195.07-10 - Lakes, bays, and sounds, or river service.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Lakes, bays, and sounds, or river service. 195.07-10 Section 195.07-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Lakes, bays, and sounds, or river service. (a) Vessels in lakes, bays, and sounds, or river service...

  2. 30 CFR 19.5 - General requirements for approval.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., AND APPROVAL OF MINING PRODUCTS ELECTRIC CAP LAMPS § 19.5 General requirements for approval. Electric cap lamps shall be complete units. They shall be durable in construction, practical in operation, and...

  3. 49 CFR 195.62 - Supplies of accident report DOT Form 7000-1.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Department will, upon request, furnish specimen copies of the form. Requests should be addressed to the... 49 Transportation 3 2010-10-01 2010-10-01 false Supplies of accident report DOT Form 7000-1. 195... Reporting § 195.62 Supplies of accident report DOT Form 7000-1. Each operator shall maintain an adequate...

  4. 21 CFR 58.195 - Retention of records.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Records and Reports § 58.195 Retention of records. (a..., documentation records, raw data and specimens pertaining to a nonclinical laboratory study and required to be...

  5. 49 CFR 195.571 - What criteria must I use to determine the adequacy of cathodic protection?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... of cathodic protection? 195.571 Section 195.571 Transportation Other Regulations Relating to... (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.571 What criteria must I use to determine the adequacy of cathodic protection? Cathodic protection required by this...

  6. 49 CFR 195.571 - What criteria must I use to determine the adequacy of cathodic protection?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of cathodic protection? 195.571 Section 195.571 Transportation Other Regulations Relating to... (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.571 What criteria must I use to determine the adequacy of cathodic protection? Cathodic protection required by this...

  7. Regulation of cell cycle checkpoint kinase WEE1 by miR-195 in malignant melanoma.

    PubMed

    Bhattacharya, A; Schmitz, U; Wolkenhauer, O; Schönherr, M; Raatz, Y; Kunz, M

    2013-06-27

    WEE1 kinase has been described as a major gate keeper at the G2 cell cycle checkpoint and to be involved in tumour progression in different malignant tumours. Here we analysed the expression levels of WEE1 in a series of melanoma patient samples and melanoma cell lines using immunoblotting, quantitative real-time PCR and immunohistochemistry. WEE1 expression was significantly downregulated in patient samples of metastatic origin as compared with primary melanomas and in melanoma cell lines of high aggressiveness as compared with cell lines of low aggressiveness. Moreover, there was an inverse correlation between the expression of WEE1 and WEE1-targeting microRNA miR-195. Further analyses showed that transfection of melanoma cell lines with miR-195 indeed reduced WEE1 mRNA and protein expression in these cells. Reporter gene analysis confirmed direct targeting of the WEE1 3' untranslated region (3'UTR) by miR-195. Overexpression of miR-195 in SK-Mel-28 melanoma cells was accompanied by WEE1 reduction and significantly reduced stress-induced G2-M cell cycle arrest, which could be restored by stable overexpression of WEE1. Moreover, miR-195 overexpression and WEE1 knockdown, respectively, increased melanoma cell proliferation. miR-195 overexpression also enhanced migration and invasiveness of melanoma cells. Taken together, the present study shows that WEE1 expression in malignant melanoma is directly regulated by miR-195. miR-195-mediated downregulation of WEE1 in metastatic lesions may help to overcome cell cycle arrest under stress conditions in the local tissue microenvironment to allow unrestricted growth of tumour cells.

  8. 21 CFR 1271.195 - Environmental control and monitoring.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... of, environmental control and monitoring activities. ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Environmental control and monitoring. 1271.195... control and monitoring. (a) Environmental control. Where environmental conditions could reasonably be...

  9. 21 CFR 1271.195 - Environmental control and monitoring.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... of, environmental control and monitoring activities. ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Environmental control and monitoring. 1271.195... control and monitoring. (a) Environmental control. Where environmental conditions could reasonably be...

  10. 21 CFR 1271.195 - Environmental control and monitoring.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of, environmental control and monitoring activities. ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Environmental control and monitoring. 1271.195... control and monitoring. (a) Environmental control. Where environmental conditions could reasonably be...

  11. 21 CFR 1271.195 - Environmental control and monitoring.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... of, environmental control and monitoring activities. ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Environmental control and monitoring. 1271.195... control and monitoring. (a) Environmental control. Where environmental conditions could reasonably be...

  12. 46 CFR 195.19-1 - When required.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MISCELLANEOUS SYSTEMS AND EQUIPMENT Magnetic Compass and Gyrocompass § 195.19-1 When required. (a) All mechanically propelled vessels in ocean or coastwise service must be fitted with a magnetic compass. (b) All... gyrocompass in addition to the magnetic compass. (c) Each vessel must have an illuminated repeater for the...

  13. 46 CFR 195.19-1 - When required.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MISCELLANEOUS SYSTEMS AND EQUIPMENT Magnetic Compass and Gyrocompass § 195.19-1 When required. (a) All mechanically propelled vessels in ocean or coastwise service must be fitted with a magnetic compass. (b) All... gyrocompass in addition to the magnetic compass. (c) Each vessel must have an illuminated repeater for the...

  14. 49 CFR 195.55 - Reporting safety-related conditions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... hazardous liquid could reasonably be expected to pollute any stream, river, lake, reservoir, or other body of water; (2) Is an accident that is required to be reported under § 195.50 or results in such an...

  15. 49 CFR 195.55 - Reporting safety-related conditions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... hazardous liquid could reasonably be expected to pollute any stream, river, lake, reservoir, or other body of water; (2) Is an accident that is required to be reported under § 195.50 or results in such an...

  16. 41 CFR 102-33.195 - Do we need an automated system to account for aircraft costs?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... system to account for aircraft costs? 102-33.195 Section 102-33.195 Public Contracts and Property... for the Cost of Government Aircraft § 102-33.195 Do we need an automated system to account for... automated system to account for aircraft costs by collecting the cost data elements required by the Federal...

  17. Decrease of miR-195 Promotes Chondrocytes Proliferation and Maintenance of Chondrogenic Phenotype via Targeting FGF-18 Pathway

    PubMed Central

    Wang, Yong; Yang, Tao; Liu, Yadong; Zhao, Wei; Zhang, Zhen; Lu, Ming; Zhang, Weiguo

    2017-01-01

    Slow growth and rapid loss of chondrogenic phenotypes are the major problems affecting chronic cartilage lesions. The role of microRNA-195 (miR-195) and its detailed working mechanism in the fore-mentioned process remains unknown. Fibroblastic growth factor 18 (FGF-18) plays a key role in cartilage homeostasis; whether miR-195 could regulate FGF-18 and its downstream signal pathway in chondrocyte proliferation and maintenance of chondrogenic phenotypes still remains unclear. The present research shows elevated miR-195 but depressed FGF-18 expressed in joint fluid specimens of 20 patients with chronic cartilage lesions and in CH1M and CH3M chondrocytes when compared with that in joint fluid specimens without cartilage lesions and in CH1W and CH2W chondrocytes, respectively. The following loss of function test revealed that downregulation of miR-195 by transfection of miR-195 inhibitors promoted chondrocyte proliferation and expression of a type II collagen α I chain (Col2a1)/aggrecan. Through the online informatics analysis we theoretically predicted that miR-195 could bind to a FGF-18 3′ untranslated region (3′UTR), also, we verified that a miR-195 could regulate the FGF-18 and its downstream pathway. The constructed dual luciferase assay further confirmed that FGF-18 was a direct target of miR-195. The executed anti-sense experiment displayed that miR-195 could regulate chondrocyte proliferation and Col2a1/aggrecan expression via the FGF-18 pathway. Finally, through an in vivo anterior cruciate ligament transection (ACLT) model, downregulation of miR-195 presented a significantly protective effect on chronic cartilage lesions. Evaluating all of the outcomes of the current research revealed that a decrease of miR-195 protected chronic cartilage lesions by promoting chondrocyte proliferation and maintenance of chondrogenic phenotypes via the targeting of the FGF-18 pathway and that the miR-195/FGF-18 axis could be a potential target in the treatment of

  18. Decrease of miR-195 Promotes Chondrocytes Proliferation and Maintenance of Chondrogenic Phenotype via Targeting FGF-18 Pathway.

    PubMed

    Wang, Yong; Yang, Tao; Liu, Yadong; Zhao, Wei; Zhang, Zhen; Lu, Ming; Zhang, Weiguo

    2017-05-04

    Slow growth and rapid loss of chondrogenic phenotypes are the major problems affecting chronic cartilage lesions. The role of microRNA-195 (miR-195) and its detailed working mechanism in the fore-mentioned process remains unknown. Fibroblastic growth factor 18 (FGF-18) plays a key role in cartilage homeostasis; whether miR-195 could regulate FGF-18 and its downstream signal pathway in chondrocyte proliferation and maintenance of chondrogenic phenotypes still remains unclear. The present research shows elevated miR-195 but depressed FGF-18 expressed in joint fluid specimens of 20 patients with chronic cartilage lesions and in CH1M and CH3M chondrocytes when compared with that in joint fluid specimens without cartilage lesions and in CH1W and CH2W chondrocytes, respectively. The following loss of function test revealed that downregulation of miR-195 by transfection of miR-195 inhibitors promoted chondrocyte proliferation and expression of a type II collagen α I chain (Col2a1)/aggrecan. Through the online informatics analysis we theoretically predicted that miR-195 could bind to a FGF-18 3' untranslated region (3'UTR), also, we verified that a miR-195 could regulate the FGF-18 and its downstream pathway. The constructed dual luciferase assay further confirmed that FGF-18 was a direct target of miR-195. The executed anti-sense experiment displayed that miR-195 could regulate chondrocyte proliferation and Col2a1/aggrecan expression via the FGF-18 pathway. Finally, through an in vivo anterior cruciate ligament transection (ACLT) model, downregulation of miR-195 presented a significantly protective effect on chronic cartilage lesions. Evaluating all of the outcomes of the current research revealed that a decrease of miR-195 protected chronic cartilage lesions by promoting chondrocyte proliferation and maintenance of chondrogenic phenotypes via the targeting of the FGF-18 pathway and that the miR-195/FGF-18 axis could be a potential target in the treatment of cartilage

  19. 46 CFR 195.17-1 - When required.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MISCELLANEOUS SYSTEMS AND EQUIPMENT Radar § 195.17-1 When required. All mechanically propelled vessels of 1,600 gross tons and over in ocean or coastwise service must be fitted with a marine radar system for surface navigation. Facilities for plotting radar readings must be provided on the bridge. [CGD 75-074, 42 FR 5965...

  20. 46 CFR 195.17-1 - When required.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MISCELLANEOUS SYSTEMS AND EQUIPMENT Radar § 195.17-1 When required. All mechanically propelled vessels of 1,600 gross tons and over in ocean or coastwise service must be fitted with a marine radar system for surface navigation. Facilities for plotting radar readings must be provided on the bridge. [CGD 75-074, 42 FR 5965...

  1. 46 CFR 195.17-1 - When required.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... MISCELLANEOUS SYSTEMS AND EQUIPMENT Radar § 195.17-1 When required. All mechanically propelled vessels of 1,600 gross tons and over in ocean or coastwise service must be fitted with a marine radar system for surface navigation. Facilities for plotting radar readings must be provided on the bridge. [CGD 75-074, 42 FR 5965...

  2. 46 CFR 195.17-1 - When required.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... MISCELLANEOUS SYSTEMS AND EQUIPMENT Radar § 195.17-1 When required. All mechanically propelled vessels of 1,600 gross tons and over in ocean or coastwise service must be fitted with a marine radar system for surface navigation. Facilities for plotting radar readings must be provided on the bridge. [CGD 75-074, 42 FR 5965...

  3. 46 CFR 195.17-1 - When required.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... MISCELLANEOUS SYSTEMS AND EQUIPMENT Radar § 195.17-1 When required. All mechanically propelled vessels of 1,600 gross tons and over in ocean or coastwise service must be fitted with a marine radar system for surface navigation. Facilities for plotting radar readings must be provided on the bridge. [CGD 75-074, 42 FR 5965...

  4. 49 CFR 195.567 - Which pipelines must have test leads and what must I do to install and maintain the leads?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... segments on which test leads were not required by regulations in effect before January 28, 2002. (b... or slack so backfilling will not unduly stress or break the lead and the lead will otherwise remain mechanically secure and electrically conductive. (3) Prevent lead attachments from causing stress...

  5. 49 CFR 195.575 - Which facilities must I electrically isolate and what inspections, tests, and safeguards are...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Which facilities must I electrically isolate and what inspections, tests, and safeguards are required? 195.575 Section 195.575 Transportation Other... Corrosion Control § 195.575 Which facilities must I electrically isolate and what inspections, tests, and...

  6. 41 CFR 102-34.195 - Must we submit a report concerning motor vehicles exempted under this subpart?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... REGULATION PERSONAL PROPERTY 34-MOTOR VEHICLE MANAGEMENT Identifying and Registering Motor Vehicles Identification Exemptions § 102-34.195 Must we submit a report concerning motor vehicles exempted under this... concerning motor vehicles exempted under this subpart? 102-34.195 Section 102-34.195 Public Contracts and...

  7. 41 CFR 102-34.195 - Must we submit a report concerning motor vehicles exempted under this subpart?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... REGULATION PERSONAL PROPERTY 34-MOTOR VEHICLE MANAGEMENT Identifying and Registering Motor Vehicles Identification Exemptions § 102-34.195 Must we submit a report concerning motor vehicles exempted under this... concerning motor vehicles exempted under this subpart? 102-34.195 Section 102-34.195 Public Contracts and...

  8. 41 CFR 102-34.195 - Must we submit a report concerning motor vehicles exempted under this subpart?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... REGULATION PERSONAL PROPERTY 34-MOTOR VEHICLE MANAGEMENT Identifying and Registering Motor Vehicles Identification Exemptions § 102-34.195 Must we submit a report concerning motor vehicles exempted under this... concerning motor vehicles exempted under this subpart? 102-34.195 Section 102-34.195 Public Contracts and...

  9. 41 CFR 102-34.195 - Must we submit a report concerning motor vehicles exempted under this subpart?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... REGULATION PERSONAL PROPERTY 34-MOTOR VEHICLE MANAGEMENT Identifying and Registering Motor Vehicles Identification Exemptions § 102-34.195 Must we submit a report concerning motor vehicles exempted under this... concerning motor vehicles exempted under this subpart? 102-34.195 Section 102-34.195 Public Contracts and...

  10. 41 CFR 102-34.195 - Must we submit a report concerning motor vehicles exempted under this subpart?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... REGULATION PERSONAL PROPERTY 34-MOTOR VEHICLE MANAGEMENT Identifying and Registering Motor Vehicles Identification Exemptions § 102-34.195 Must we submit a report concerning motor vehicles exempted under this... concerning motor vehicles exempted under this subpart? 102-34.195 Section 102-34.195 Public Contracts and...

  11. 49 CFR 195.303 - Risk-based alternative to pressure testing older hazardous liquid and carbon dioxide pipelines.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Pressure Testing § 195.303 Risk-based alternative to pressure testing older hazardous liquid and carbon... 49 Transportation 3 2014-10-01 2014-10-01 false Risk-based alternative to pressure testing older hazardous liquid and carbon dioxide pipelines. 195.303 Section 195.303 Transportation Other Regulations...

  12. 49 CFR 195.303 - Risk-based alternative to pressure testing older hazardous liquid and carbon dioxide pipelines.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Pressure Testing § 195.303 Risk-based alternative to pressure testing older hazardous liquid and carbon... 49 Transportation 3 2013-10-01 2013-10-01 false Risk-based alternative to pressure testing older hazardous liquid and carbon dioxide pipelines. 195.303 Section 195.303 Transportation Other Regulations...

  13. 49 CFR 195.303 - Risk-based alternative to pressure testing older hazardous liquid and carbon dioxide pipelines.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Pressure Testing § 195.303 Risk-based alternative to pressure testing older hazardous liquid and carbon... 49 Transportation 3 2012-10-01 2012-10-01 false Risk-based alternative to pressure testing older hazardous liquid and carbon dioxide pipelines. 195.303 Section 195.303 Transportation Other Regulations...

  14. 32 CFR Appendix A to Part 195 - Programs to Which This Part Applies

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-EFFECTUATION OF TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 Pt. 195, App. A Appendix A to Part 195—Programs to... Defense assistance to programs of adult education in civil defense subjects (50 United States Code App. 2281 (e), (f)). 6. Office of Civil Defense radiological instruments grants (50 United States Code App...

  15. 32 CFR Appendix A to Part 195 - Programs to Which This Part Applies

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-EFFECTUATION OF TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 Pt. 195, App. A Appendix A to Part 195—Programs to... Defense assistance to programs of adult education in civil defense subjects (50 United States Code App. 2281 (e), (f)). 6. Office of Civil Defense radiological instruments grants (50 United States Code App...

  16. 27 CFR 46.195 - Floor stocks requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Tubes Held for Sale on April 1, 2009 General § 46.195 Floor stocks requirements. (a) Take inventory. The dealer must establish the quantity of articles subject to the floor stocks tax held for sale on April 1, 2009. The dealer may take a physical inventory or may use a record (book) inventory, as specified in...

  17. 49 CFR 195.4 - Compatibility necessary for transportation of hazardous liquids or carbon dioxide.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Compatibility necessary for transportation of hazardous liquids or carbon dioxide. 195.4 Section 195.4 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY...

  18. 49 CFR 195.4 - Compatibility necessary for transportation of hazardous liquids or carbon dioxide.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Compatibility necessary for transportation of hazardous liquids or carbon dioxide. 195.4 Section 195.4 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY...

  19. 49 CFR 195.4 - Compatibility necessary for transportation of hazardous liquids or carbon dioxide.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Compatibility necessary for transportation of hazardous liquids or carbon dioxide. 195.4 Section 195.4 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY...

  20. 49 CFR 195.4 - Compatibility necessary for transportation of hazardous liquids or carbon dioxide.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... hazardous liquids or carbon dioxide. 195.4 Section 195.4 Transportation Other Regulations Relating to... necessary for transportation of hazardous liquids or carbon dioxide. No person may transport any hazardous liquid or carbon dioxide unless the hazardous liquid or carbon dioxide is chemically compatible with both...

  1. 49 CFR 195.4 - Compatibility necessary for transportation of hazardous liquids or carbon dioxide.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... hazardous liquids or carbon dioxide. 195.4 Section 195.4 Transportation Other Regulations Relating to... necessary for transportation of hazardous liquids or carbon dioxide. No person may transport any hazardous liquid or carbon dioxide unless the hazardous liquid or carbon dioxide is chemically compatible with both...

  2. 34 CFR 403.195 - What are the administrative cost requirements applicable to local recipients?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false What are the administrative cost requirements applicable to local recipients? 403.195 Section 403.195 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE...

  3. 34 CFR 403.195 - What are the administrative cost requirements applicable to local recipients?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false What are the administrative cost requirements applicable to local recipients? 403.195 Section 403.195 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE...

  4. 34 CFR 403.195 - What are the administrative cost requirements applicable to local recipients?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false What are the administrative cost requirements applicable to local recipients? 403.195 Section 403.195 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE...

  5. 34 CFR 403.195 - What are the administrative cost requirements applicable to local recipients?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false What are the administrative cost requirements applicable to local recipients? 403.195 Section 403.195 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE...

  6. 46 CFR 195.03-1 - Installation and details.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Marine Engineering Systems § 195.03-1 Installation and details. (a) The installation of all systems of a marine engineering nature, together with the details of... (Marine Engineering) of this chapter. Systems of this type include the following: Steering Systems. Bilge...

  7. 40 CFR 195.30 - Failure to remit fee.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PROGRAMS RADON PROFICIENCY PROGRAMS Fees § 195.30 Failure to remit fee. EPA will not process an application or continue a participant's listing in the National Radon Measurement Proficiency program, individual proficiency component of the RMP program, or the National Radon Contractor Proficiency program until the...

  8. 40 CFR 195.30 - Failure to remit fee.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROGRAMS RADON PROFICIENCY PROGRAMS Fees § 195.30 Failure to remit fee. EPA will not process an application or continue a participant's listing in the National Radon Measurement Proficiency program, individual proficiency component of the RMP program, or the National Radon Contractor Proficiency program until the...

  9. 1. View of bridge from Interstate 195 (Washington Bridge) looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. View of bridge from Interstate 195 (Washington Bridge) looking southwest - India Point Railroad Bridge, Spanning Seekonk River between Providence & East Providence, Providence, Providence County, RI

  10. 28 CFR 19.5 - Report to the Office of Juvenile Justice and Delinquency Prevention.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Report to the Office of Juvenile Justice and Delinquency Prevention. 19.5 Section 19.5 Judicial Administration DEPARTMENT OF JUSTICE USE OF... Justice and Delinquency Prevention. DOJ will compile and submit to OJJDP, by June 30, 1987, a consolidated...

  11. Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model

    PubMed Central

    Adamson Barnes, Nicholas S.; Mitchell, Vanessa A.; Kazantzis, Nicholas P.

    2015-01-01

    Background and Purpose While cannabinoids have been proposed as a potential treatment for neuropathic pain, they have limitations. Cannabinoid receptor agonists have good efficacy in animal models of neuropathic pain; they have a poor therapeutic window. Conversely, selective fatty acid amide hydrolase (FAAH) inhibitors that enhance the endocannabinoid system have a better therapeutic window, but lesser efficacy. We examined whether JZL195, a dual inhibitor of FAAH and monacylglycerol lipase (MAGL), could overcome these limitations. Experimental Approach C57BL/6 mice underwent the chronic constriction injury (CCI) model of neuropathic pain. Mechanical and cold allodynia, plus cannabinoid side effects, were assessed in response to systemic drug application. Key Results JZL195 and the cannabinoid receptor agonist WIN55212 produced dose‐dependent reductions in CCI‐induced mechanical and cold allodynia, plus side effects including motor incoordination, catalepsy and sedation. JZL195 reduced allodynia with an ED50 at least four times less than that at which it produced side effects. By contrast, WIN55212 reduced allodynia and produce side effects with similar ED50s. The maximal anti‐allodynic effect of JZL195 was greater than that produced by selective FAAH, or MAGL inhibitors. The JZL195‐induced anti‐allodynia was maintained during repeated treatment. Conclusions and Implications These findings suggest that JZL195 has greater anti‐allodynic efficacy than selective FAAH, or MAGL inhibitors, plus a greater therapeutic window than a cannabinoid receptor agonist. Thus, dual FAAH/MAGL inhibition may have greater potential in alleviating neuropathic pain, compared with selective FAAH and MAGL inhibitors, or cannabinoid receptor agonists. PMID:26398331

  12. 49 CFR 195.413 - Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the Gulf of Mexico and its inlets. 195.413 Section 195.413 Transportation Other Regulations Relating... Maintenance § 195.413 Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets. (a... shall prepare and follow a procedure to identify its pipelines in the Gulf of Mexico and its inlets in...

  13. 41 CFR 102-36.195 - What type of excess personal property may we furnish to our project grantees?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What type of excess personal property may we furnish to our project grantees? 102-36.195 Section 102-36.195 Public Contracts... for Non-Federal Recipients Project Grantees § 102-36.195 What type of excess personal property may we...

  14. 41 CFR 102-36.195 - What type of excess personal property may we furnish to our project grantees?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false What type of excess personal property may we furnish to our project grantees? 102-36.195 Section 102-36.195 Public Contracts... for Non-Federal Recipients Project Grantees § 102-36.195 What type of excess personal property may we...

  15. 41 CFR 102-36.195 - What type of excess personal property may we furnish to our project grantees?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What type of excess personal property may we furnish to our project grantees? 102-36.195 Section 102-36.195 Public Contracts... for Non-Federal Recipients Project Grantees § 102-36.195 What type of excess personal property may we...

  16. 41 CFR 102-36.195 - What type of excess personal property may we furnish to our project grantees?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false What type of excess personal property may we furnish to our project grantees? 102-36.195 Section 102-36.195 Public Contracts... for Non-Federal Recipients Project Grantees § 102-36.195 What type of excess personal property may we...

  17. 49 CFR 195.413 - Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... the Gulf of Mexico and its inlets. 195.413 Section 195.413 Transportation Other Regulations Relating... Maintenance § 195.413 Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets. (a... shall prepare and follow a procedure to identify its pipelines in the Gulf of Mexico and its inlets in...

  18. 49 CFR 195.413 - Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... the Gulf of Mexico and its inlets. 195.413 Section 195.413 Transportation Other Regulations Relating... Maintenance § 195.413 Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets. (a... shall prepare and follow a procedure to identify its pipelines in the Gulf of Mexico and its inlets in...

  19. 49 CFR 195.413 - Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the Gulf of Mexico and its inlets. 195.413 Section 195.413 Transportation Other Regulations Relating... Maintenance § 195.413 Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets. (a... shall prepare and follow a procedure to identify its pipelines in the Gulf of Mexico and its inlets in...

  20. 49 CFR 195.413 - Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the Gulf of Mexico and its inlets. 195.413 Section 195.413 Transportation Other Regulations Relating... Maintenance § 195.413 Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets. (a... shall prepare and follow a procedure to identify its pipelines in the Gulf of Mexico and its inlets in...

  1. 7 CFR 4280.195 - Awarding and administering energy audit and renewable energy development assistance grants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Awarding and administering energy audit and renewable energy development assistance grants. 4280.195 Section 4280.195 Agriculture Regulations of the Department... OF AGRICULTURE LOANS AND GRANTS Rural Energy for America Program General Energy Audit and Renewable...

  2. Sustainable growth of Dehalococcoides mccartyi 195 by corrinoid salvaging and remodeling in defined lactate-fermenting consortia.

    PubMed

    Men, Yujie; Seth, Erica C; Yi, Shan; Allen, Robert H; Taga, Michiko E; Alvarez-Cohen, Lisa

    2014-04-01

    Corrinoids are essential cofactors of reductive dehalogenases in Dehalococcoides mccartyi, an important bacterium in bioremediation, yet sequenced D. mccartyi strains do not possess the complete pathway for de novo corrinoid biosynthesis. Pelosinus sp. and Desulfovibrio sp. have been detected in dechlorinating communities enriched from contaminated groundwater without exogenous cobalamin corrinoid. To investigate the corrinoid-related interactions among key members of these communities, we constructed consortia by growing D. mccartyi strain 195 (Dhc195) in cobalamin-free, trichloroethene (TCE)- and lactate-amended medium in cocultures with Desulfovibrio vulgaris Hildenborough (DvH) or Pelosinus fermentans R7 (PfR7) and with both in tricultures. Only the triculture exhibited sustainable dechlorination and cell growth when a physiological level of 5,6-dimethylbenzimidazole (DMB), the lower ligand of cobalamin, was provided. In the triculture, DvH provided hydrogen while PfR7 provided corrinoids to Dhc195, and the initiation of dechlorination and Dhc195 cell growth was highly dependent on the growth of PfR7. Corrinoid analysis indicated that Dhc195 imported and remodeled the phenolic corrinoids produced by PfR7 into cobalamin in the presence of DMB. Transcriptomic analyses of Dhc195 showed the induction of the CbiZ-dependent corrinoid-remodeling pathway and BtuFCD corrinoid ABC transporter genes during corrinoid salvaging and remodeling. In contrast, another operon annotated to encode a putative iron/cobalamin ABC transporter (DET1174-DET1176) was induced when cobalamin was exogenously provided. Interestingly, a global upregulation of phage-related genes was observed when PfR7 was present. These findings provide insights into both the gene regulation of corrinoid salvaging and remodeling in Dhc195 when it is grown without exogenous cobalamin and microbe-to-microbe interactions in dechlorinating microbial communities.

  3. 14 CFR 221.195 - Requirement for filing printed material.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS Electronically Filed Tariffs § 221.195 Requirement for filing printed material. (a) Any tariff, or revision thereto, filed in paper format which accompanies....190(b). Further, such paper tariff, or revision thereto, shall be filed in accordance with the...

  4. 49 CFR 195.57 - Filing offshore pipeline condition reports.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Annual, Accident, and Safety-Related Condition Reporting § 195.57... information: (1) Name and principal address of operator. (2) Date of report. (3) Name, job title, and business...

  5. 7 CFR 3015.195 - Subgrants and cost-type contracts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...-21 would apply to the costs incurred by the institution of higher education even though OMB Circular A-87 would apply to the costs incurred by the State. ... 7 Agriculture 15 2010-01-01 2010-01-01 false Subgrants and cost-type contracts. 3015.195 Section...

  6. 49 CFR 195.59 - Abandonment or deactivation of facilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Abandonment or deactivation of facilities. 195.59... Abandonment or deactivation of facilities. For each abandoned offshore pipeline facility or each abandoned onshore pipeline facility that crosses over, under or through a commercially navigable waterway, the last...

  7. 49 CFR 195.11 - What is a regulated rural gathering line and what requirements apply?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... established under § 195.406 corresponding to— (i) A stress level greater than 20-percent of the specified minimum yield strength of the line pipe; or (ii) If the stress level is unknown or the pipeline is not....410. (7) Establish a continuing public education program in compliance with § 195.440 before...

  8. 49 CFR 195.11 - What is a regulated rural gathering line and what requirements apply?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... established under § 195.406 corresponding to— (i) A stress level greater than 20-percent of the specified minimum yield strength of the line pipe; or (ii) If the stress level is unknown or the pipeline is not....410. (7) Establish a continuing public education program in compliance with § 195.440 before...

  9. 49 CFR 195.11 - What is a regulated rural gathering line and what requirements apply?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... established under § 195.406 corresponding to— (i) A stress level greater than 20-percent of the specified minimum yield strength of the line pipe; or (ii) If the stress level is unknown or the pipeline is not....410. (7) Establish a continuing public education program in compliance with § 195.440 before...

  10. Sustainable syntrophic growth of Dehalococcoides ethenogenes strain 195 with Desulfovibrio vulgaris Hildenborough and Methanobacterium congolense: global transcriptomic and proteomic analyses

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Men, Yujie; Feil, Helene; Verberkmoes, Nathan C

    2012-01-01

    Dehalococcoides ethenogenes strain 195 (DE195) was grown in a sustainable syntrophic association with Desulfovibrio vulgaris Hildenborough (DVH) as a co-culture, as well as with DVH and the hydrogenotrophic methanogen Methanobacterium congolense (MC) as a tri-culture using lactate as the sole energy and carbon source. In the co- and tri-cultures, maximum dechlorination rates of DE195 were enhanced by approximately three times (11.0 0.01 lmol per day for the co-culture and 10.1 0.3 lmol per day for the tri-culture) compared with DE195 grown alone (3.8 0.1 lmol per day). Cell yield of DE195 was enhanced in the co-culture (9.0 0.5107 cells permore » lmol Cl released, compared with 6.8 0.9107 cells per lmol Cl released for the pure culture), whereas no further enhancement was observed in the tri-culture (7.3 1.8107 cells per lmol Cl released). The transcriptome of DE195 grown in the co-culture was analyzed using a wholegenome microarray targeting DE195, which detected 102 significantly up- or down-regulated genes compared with DE195 grown in isolation, whereas no significant transcriptomic difference was observed between co- and tri-cultures. Proteomic analysis showed that 120 proteins were differentially expressed in the co-culture compared with DE195 grown in isolation. Physiological, transcriptomic and proteomic results indicate that the robust growth of DE195 in co- and tri-cultures is because of the advantages associated with the capabilities of DVH to ferment lactate to provide H2 and acetate for growth, along with potential benefits from proton translocation, cobalamin-salvaging and amino acid biosynthesis, whereas MC in the tri-culture provided no significant additional benefits beyond those of DVH.« less

  11. 41 CFR 102-37.195 - Does a SASP have to have a donee in mind to request surplus property?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Does a SASP have to have a donee in mind to request surplus property? 102-37.195 Section 102-37.195 Public Contracts and...) Screening and Requesting Property § 102-37.195 Does a SASP have to have a donee in mind to request surplus...

  12. 41 CFR 102-37.195 - Does a SASP have to have a donee in mind to request surplus property?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Does a SASP have to have a donee in mind to request surplus property? 102-37.195 Section 102-37.195 Public Contracts and...) Screening and Requesting Property § 102-37.195 Does a SASP have to have a donee in mind to request surplus...

  13. 41 CFR 102-37.195 - Does a SASP have to have a donee in mind to request surplus property?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Does a SASP have to have a donee in mind to request surplus property? 102-37.195 Section 102-37.195 Public Contracts and...) Screening and Requesting Property § 102-37.195 Does a SASP have to have a donee in mind to request surplus...

  14. 41 CFR 102-37.195 - Does a SASP have to have a donee in mind to request surplus property?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Does a SASP have to have a donee in mind to request surplus property? 102-37.195 Section 102-37.195 Public Contracts and...) Screening and Requesting Property § 102-37.195 Does a SASP have to have a donee in mind to request surplus...

  15. 41 CFR 102-37.195 - Does a SASP have to have a donee in mind to request surplus property?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Does a SASP have to have a donee in mind to request surplus property? 102-37.195 Section 102-37.195 Public Contracts and...) Screening and Requesting Property § 102-37.195 Does a SASP have to have a donee in mind to request surplus...

  16. 14 CFR 21.195 - Experimental certificates: Aircraft to be used for market surveys, sales demonstrations, and...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... used for market surveys, sales demonstrations, and customer crew training. 21.195 Section 21.195... be used for market surveys, sales demonstrations, and customer crew training. (a) A manufacturer of... that is to be used for market surveys, sales demonstrations, or customer crew training. (b) A...

  17. 14 CFR 21.195 - Experimental certificates: Aircraft to be used for market surveys, sales demonstrations, and...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... used for market surveys, sales demonstrations, and customer crew training. 21.195 Section 21.195... be used for market surveys, sales demonstrations, and customer crew training. (a) A manufacturer of... that is to be used for market surveys, sales demonstrations, or customer crew training. (b) A...

  18. 14 CFR 21.195 - Experimental certificates: Aircraft to be used for market surveys, sales demonstrations, and...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... used for market surveys, sales demonstrations, and customer crew training. 21.195 Section 21.195... be used for market surveys, sales demonstrations, and customer crew training. (a) A manufacturer of... that is to be used for market surveys, sales demonstrations, or customer crew training. (b) A...

  19. 14 CFR 21.195 - Experimental certificates: Aircraft to be used for market surveys, sales demonstrations, and...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... used for market surveys, sales demonstrations, and customer crew training. 21.195 Section 21.195... be used for market surveys, sales demonstrations, and customer crew training. (a) A manufacturer of... that is to be used for market surveys, sales demonstrations, or customer crew training. (b) A...

  20. 49 CFR 195.264 - Impoundment, protection against entry, normal/emergency venting or pressure/vacuum relief for...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... devices must be provided for each low-pressure and high-pressure breakout tank. (e) For normal/emergency... and vacuum-relieving devices installed on high pressure tanks built to API Standard 2510 (incorporated.../emergency venting or pressure/vacuum relief for aboveground breakout tanks. 195.264 Section 195.264...

  1. 14 CFR 21.195 - Experimental certificates: Aircraft to be used for market surveys, sales demonstrations, and...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... used for market surveys, sales demonstrations, and customer crew training. 21.195 Section 21.195... be used for market surveys, sales demonstrations, and customer crew training. Link to an amendment... States may apply for an experimental certificate for an aircraft that is to be used for market surveys...

  2. 49 CFR 195.307 - Pressure testing aboveground breakout tanks.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... aboveground breakout tanks. (a) For aboveground breakout tanks built into API Specification 12F and first placed in service after October 2, 2000, pneumatic testing must be in accordance with section 5.3 of API Specification 12 F (incorporated by reference, see § 195.3). (b) For aboveground breakout tanks built to API...

  3. 49 CFR 195.307 - Pressure testing aboveground breakout tanks.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... aboveground breakout tanks. (a) For aboveground breakout tanks built into API Specification 12F and first placed in service after October 2, 2000, pneumatic testing must be in accordance with section 5.3 of API Specification 12 F (incorporated by reference, see § 195.3). (b) For aboveground breakout tanks built to API...

  4. 49 CFR 195.307 - Pressure testing aboveground breakout tanks.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... aboveground breakout tanks. (a) For aboveground breakout tanks built into API Specification 12F and first placed in service after October 2, 2000, pneumatic testing must be in accordance with section 5.3 of API Specification 12 F (incorporated by reference, see § 195.3). (b) For aboveground breakout tanks built to API...

  5. 49 CFR 195.307 - Pressure testing aboveground breakout tanks.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... aboveground breakout tanks. (a) For aboveground breakout tanks built into API Specification 12F and first placed in service after October 2, 2000, pneumatic testing must be in accordance with section 5.3 of API Specification 12 F (incorporated by reference, see § 195.3). (b) For aboveground breakout tanks built to API...

  6. 49 CFR 195.588 - What standards apply to direct assessment?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.588 What standards apply to direct... corrosion, you must follow the requirements of this section for performing external corrosion direct... direct assessment process. (b) The requirements for performing external corrosion direct assessment are...

  7. 49 CFR 195.588 - What standards apply to direct assessment?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.588 What standards apply to direct... corrosion, you must follow the requirements of this section for performing external corrosion direct... direct assessment process. (b) The requirements for performing external corrosion direct assessment are...

  8. 49 CFR 195.588 - What standards apply to direct assessment?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.588 What standards apply to direct... corrosion, you must follow the requirements of this section for performing external corrosion direct... direct assessment process. (b) The requirements for performing external corrosion direct assessment are...

  9. 49 CFR 195.588 - What standards apply to direct assessment?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.588 What standards apply to direct... corrosion, you must follow the requirements of this section for performing external corrosion direct... direct assessment process. (b) The requirements for performing external corrosion direct assessment are...

  10. 41 CFR 102-73.195 - What types of special purpose space may the Department of Health and Human Services lease?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... purpose space may the Department of Health and Human Services lease? 102-73.195 Section 102-73.195 Public... Delegations § 102-73.195 What types of special purpose space may the Department of Health and Human Services lease? The Department of Health and Human Services is delegated authority to lease laboratories (lease...

  11. 49 CFR 195.307 - Pressure testing aboveground breakout tanks.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... placed in service after October 2, 2000, pneumatic testing must be in accordance with section 5.3 of API Specification 12 F (incorporated by reference, see § 195.3). (b) For aboveground breakout tanks built to API Standard 620 and first placed in service after October 2, 2000, hydrostatic and pneumatic testing must be...

  12. MicroRNA-195 targets ADP-ribosylation factor-like protein 2 to induce apoptosis in human embryonic stem cell-derived neural progenitor cells

    PubMed Central

    Zhou, Y; Jiang, H; Gu, J; Tang, Y; Shen, N; Jin, Y

    2013-01-01

    Neural progenitor cells (NPCs) derived from human embryonic stem cells (hESCs) have great potential in cell therapy, drug screening and toxicity testing of neural degenerative diseases. However, the molecular regulation of their proliferation and apoptosis, which needs to be revealed before clinical application, is largely unknown. MicroRNA miR-195 is known to be expressed in the brain and is involved in a variety of proapoptosis or antiapoptosis processes in cancer cells. Here, we defined the proapoptotic role of miR-195 in NPCs derived from two independent hESC lines (human embryonic stem cell-derived neural progenitor cells, hESC-NPCs). Overexpression of miR-195 in hESC-NPCs induced extensive apoptotic cell death. Consistently, global transcriptional microarray analyses indicated that miR-195 primarily regulated genes associated with apoptosis in hESC-NPCs. Mechanistically, a small GTP-binding protein ADP-ribosylation factor-like protein 2 (ARL2) was identified as a direct target of miR-195. Silencing ARL2 in hESC-NPCs provoked an apoptotic phenotype resembling that of miR-195 overexpression, revealing for the first time an essential role of ARL2 for the survival of human NPCs. Moreover, forced expression of ALR2 could abolish the cell number reduction caused by miR-195 overexpression. Interestingly, we found that paraquat, a neurotoxin, not only induced apoptosis but also increased miR-195 and reduced ARL2 expression in hESC-NPCs, indicating the possible involvement of miR-195 and ARL2 in neurotoxin-induced NPC apoptosis. Notably, inhibition of miR-195 family members could block neurotoxin-induced NPC apoptosis. Collectively, miR-195 regulates cell apoptosis in a context-dependent manner through directly targeting ARL2. The finding of the critical role of ARL2 for the survival of human NPCs and association of miR-195 and ARL2 with neurotoxin-induced apoptosis have important implications for understanding molecular mechanisms that control NPC survival and would

  13. 195. Photocopy of drawing, Twin Falls Canal Company, date unknown. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    195. Photocopy of drawing, Twin Falls Canal Company, date unknown. PLAN OF CONSTRUCTION AREA PLANT, TWIN FALLS COUNTY, MILNER, IDAHO; BLUEPRINT. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  14. 49 CFR 195.8 - Transportation of hazardous liquid or carbon dioxide in pipelines constructed with other than...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... dioxide in pipelines constructed with other than steel pipe. 195.8 Section 195.8 Transportation Other... than steel pipe. No person may transport any hazardous liquid or carbon dioxide through a pipe that is... other than steel unless the person has notified the Administrator in writing at least 90 days before the...

  15. 49 CFR 195.8 - Transportation of hazardous liquid or carbon dioxide in pipelines constructed with other than...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... dioxide in pipelines constructed with other than steel pipe. 195.8 Section 195.8 Transportation Other... than steel pipe. No person may transport any hazardous liquid or carbon dioxide through a pipe that is... other than steel unless the person has notified the Administrator in writing at least 90 days before the...

  16. 49 CFR 195.8 - Transportation of hazardous liquid or carbon dioxide in pipelines constructed with other than...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... dioxide in pipelines constructed with other than steel pipe. 195.8 Section 195.8 Transportation Other... than steel pipe. No person may transport any hazardous liquid or carbon dioxide through a pipe that is... other than steel unless the person has notified the Administrator in writing at least 90 days before the...

  17. 49 CFR 195.8 - Transportation of hazardous liquid or carbon dioxide in pipelines constructed with other than...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... dioxide in pipelines constructed with other than steel pipe. 195.8 Section 195.8 Transportation Other... than steel pipe. No person may transport any hazardous liquid or carbon dioxide through a pipe that is... other than steel unless the person has notified the Administrator in writing at least 90 days before the...

  18. 49 CFR 195.8 - Transportation of hazardous liquid or carbon dioxide in pipelines constructed with other than...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... dioxide in pipelines constructed with other than steel pipe. 195.8 Section 195.8 Transportation Other... than steel pipe. No person may transport any hazardous liquid or carbon dioxide through a pipe that is... other than steel unless the person has notified the Administrator in writing at least 90 days before the...

  19. 49 CFR 195.303 - Risk-based alternative to pressure testing older hazardous liquid and carbon dioxide pipelines.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... criteria as an alternative to the pressure testing in § 195.302(b)(1)(i)-(iii) and § 195.302(b)(2)(i) of... in paragraph (b) of this section as follows: (1) Risk Classification A if the location indicator is ranked as low or medium risk, the product and volume indicators are ranked as low risk, and the...

  20. 49 CFR 195.303 - Risk-based alternative to pressure testing older hazardous liquid and carbon dioxide pipelines.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... criteria as an alternative to the pressure testing in § 195.302(b)(1)(i)-(iii) and § 195.302(b)(2)(i) of... in paragraph (b) of this section as follows: (1) Risk Classification A if the location indicator is ranked as low or medium risk, the product and volume indicators are ranked as low risk, and the...

  1. 41 CFR 102-36.195 - What type of excess personal property may we furnish to our project grantees?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What type of excess personal property may we furnish to our project grantees? 102-36.195 Section 102-36.195 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT...

  2. 49 CFR 195.132 - Design and construction of aboveground breakout tanks.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.132 Design and... to withstand the internal pressure produced by the hazardous liquid to be stored therein and any...) and with internal vapor space pressures that are approximately atmospheric must be designed and...

  3. 49 CFR 195.132 - Design and construction of aboveground breakout tanks.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.132 Design and... to withstand the internal pressure produced by the hazardous liquid to be stored therein and any...) and with internal vapor space pressures that are approximately atmospheric must be designed and...

  4. 49 CFR 195.132 - Design and construction of aboveground breakout tanks.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.132 Design and... to withstand the internal pressure produced by the hazardous liquid to be stored therein and any...) and with internal vapor space pressures that are approximately atmospheric must be designed and...

  5. 49 CFR 195.132 - Design and construction of aboveground breakout tanks.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.132 Design and... to withstand the internal pressure produced by the hazardous liquid to be stored therein and any...) and with internal vapor space pressures that are approximately atmospheric must be designed and...

  6. 49 CFR 195.132 - Design and construction of aboveground breakout tanks.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Design Requirements § 195.132 Design and... to withstand the internal pressure produced by the hazardous liquid to be stored therein and any...) and with internal vapor space pressures that are approximately atmospheric must be designed and...

  7. 15 CFR 19.5 - How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce debt? 19.5 Section 19.5 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect Commerce...

  8. 15 CFR 19.5 - How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce debt? 19.5 Section 19.5 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect Commerce...

  9. 15 CFR 19.5 - How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce debt? 19.5 Section 19.5 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect Commerce...

  10. 15 CFR 19.5 - How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce debt? 19.5 Section 19.5 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect Commerce...

  11. 15 CFR 19.5 - How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce debt? 19.5 Section 19.5 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect Commerce...

  12. Synthesis and magnetostrictive properties of Pr(Fe1.95B0.05)1.93 bulk nanocrystalline alloy

    NASA Astrophysics Data System (ADS)

    Shi, Y. G.; Hu, C. C.; Fan, J. Y.; Shi, D. N.; Lv, L. Y.; Tang, S. L.

    2012-11-01

    The structure, magnetic properties, and magnetostriction of Pr(Fe1.95B0.05)1.93 alloys prepared by annealing its precursor amorphous ribbons under high pressure were investigated. It was found that Pr(Fe1.95B0.05)1.93 single cubic Laves phase could be obtained only when the pressure is up to 3 GPa. The average grain size about 20 nm is found in the sample synthesized under 6 GPa. A large linear magnetostriction of 541 ppm at 3 kOe is observed in the Pr(Fe1.95B0.05)1.93 compound synthesized under 6 GPa, which is 25% larger than that under 3 GPa. The present work offers an effective method to obtain bulk nanocrystalline magnetostrictive compounds.

  13. 49 CFR 195.228 - Welds and welding inspection: Standards of acceptability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welds and welding inspection: Standards of... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.228 Welds and welding inspection: Standards of acceptability. (a) Each weld and welding must be inspected to insure compliance with...

  14. 14 CFR Sec. 19-5 - Air transport traffic and capacity elements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Air transport traffic and capacity elements... AIR CARRIERS Operating Statistics Classifications Sec. 19-5 Air transport traffic and capacity... reported as applicable to specified air transport traffic and capacity elements. (b) These reported items...

  15. 14 CFR Sec. 19-5 - Air transport traffic and capacity elements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Air transport traffic and capacity elements... AIR CARRIERS Operating Statistics Classifications Sec. 19-5 Air transport traffic and capacity... reported as applicable to specified air transport traffic and capacity elements. (b) These reported items...

  16. 49 CFR 195.228 - Welds and welding inspection: Standards of acceptability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Welds and welding inspection: Standards of... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.228 Welds and welding inspection: Standards of acceptability. (a) Each weld and welding must be inspected to insure compliance with...

  17. 49 CFR 195.228 - Welds and welding inspection: Standards of acceptability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Welds and welding inspection: Standards of... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.228 Welds and welding inspection: Standards of acceptability. (a) Each weld and welding must be inspected to insure compliance with...

  18. 49 CFR 195.228 - Welds and welding inspection: Standards of acceptability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Welds and welding inspection: Standards of... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.228 Welds and welding inspection: Standards of acceptability. (a) Each weld and welding must be inspected to insure compliance with...

  19. 49 CFR 195.228 - Welds and welding inspection: Standards of acceptability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Welds and welding inspection: Standards of... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.228 Welds and welding inspection: Standards of acceptability. (a) Each weld and welding must be inspected to insure compliance with...

  20. 49 CFR 195.452 - Pipeline integrity management in high consequence areas.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Pipeline integrity management in high consequence... Management § 195.452 Pipeline integrity management in high consequence areas. (a) Which pipelines are covered... by this section must: (1) Develop a written integrity management program that addresses the risks on...

  1. 49 CFR 195.452 - Pipeline integrity management in high consequence areas.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Pipeline integrity management in high consequence... Management § 195.452 Pipeline integrity management in high consequence areas. (a) Which pipelines are covered... by this section must: (1) Develop a written integrity management program that addresses the risks on...

  2. 49 CFR 195.452 - Pipeline integrity management in high consequence areas.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Pipeline integrity management in high consequence... Management § 195.452 Pipeline integrity management in high consequence areas. (a) Which pipelines are covered... by this section must: (1) Develop a written integrity management program that addresses the risks on...

  3. Comparison of the AMDAHL 470V/6 and the IBM 370/195 using benchmarks

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Snider, D.R.; Midlock, J.L.; Hinds, A.R.

    1976-03-01

    Six groups of jobs were run on the IBM 370/195 at the Applied Mathematics Division (AMD) of Argonne National Laboratory using the current production versions of OS/MVT 21.7 and ASP 3.1. The same jobs were then run on an AMDAHL 470V/6 at the AMDAHL manufacturing facilities in Sunnyvale, California, using the identical operating systems. Performances of the two machines are compared. Differences in the configurations were minimized. The memory size on each machine was the same, all software which had an impact on run times was the same, and the I/O configurations were as similar as possible. This allowed themore » comparison to be based on the relative performance of the two CPU's. As part of the studies preliminary to the acquisition of the IBM 195 in 1972, two of the groups of jobs had been run on a CDC 7600 by CDC personnel in Arden Hills, Minnesota, on an IBM 360/195 by IBM personnel in Poughkeepsie, New York, and on the AMD 360/50/75 production system in June, 1971. 6 figures, 9 tables.« less

  4. 14 CFR 121.195 - Airplanes: Turbine engine powered: Landing limitations: Destination airports.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Airplanes: Turbine engine powered: Landing...: CERTIFICATION AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Airplane Performance Operating Limitations § 121.195 Airplanes: Turbine engine powered: Landing limitations...

  5. 14 CFR 121.195 - Airplanes: Turbine engine powered: Landing limitations: Destination airports.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Airplanes: Turbine engine powered: Landing...: CERTIFICATION AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Airplane Performance Operating Limitations § 121.195 Airplanes: Turbine engine powered: Landing limitations...

  6. 14 CFR 121.195 - Airplanes: Turbine engine powered: Landing limitations: Destination airports.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Airplanes: Turbine engine powered: Landing...: CERTIFICATION AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Airplane Performance Operating Limitations § 121.195 Airplanes: Turbine engine powered: Landing limitations...

  7. Monetary benefits of preventing childhood lead poisoning with lead-safe window replacement.

    PubMed

    Nevin, Rick; Jacobs, David E; Berg, Michael; Cohen, Jonathan

    2008-03-01

    Previous estimates of childhood lead poisoning prevention benefits have quantified the present value of some health benefits, but not the costs of lead paint hazard control or the benefits associated with housing and energy markets. Because older housing with lead paint constitutes the main exposure source today in the US, we quantify health benefits, costs, market value benefits, energy savings, and net economic benefits of lead-safe window replacement (which includes paint stabilization and other measures). The benefit per resident child from improved lifetime earnings alone is $21,195 in pre-1940 housing and $8685 in 1940-59 housing (in 2005 dollars). Annual energy savings are $130-486 per housing unit, with or without young resident children, with an associated increase in housing market value of $5900-14,300 per housing unit, depending on home size and number of windows replaced. Net benefits are $4490-5,629 for each housing unit built before 1940, and $491-1629 for each unit built from 1940-1959, depending on home size and number of windows replaced. Lead-safe window replacement in all pre-1960 US housing would yield net benefits of at least $67 billion, which does not include many other benefits. These other benefits, which are shown in this paper, include avoided Attention Deficit Hyperactivity Disorder, other medical costs of childhood lead exposure, avoided special education, and reduced crime and juvenile delinquency in later life. In addition, such a window replacement effort would reduce peak demand for electricity, carbon emissions from power plants, and associated long-term costs of climate change.

  8. Hsa-miR-195 targets PCMT1 in hepatocellular carcinoma that increases tumor life span.

    PubMed

    Amer, Marwa; Elhefnawi, M; El-Ahwany, Eman; Awad, A F; Gawad, Nermen Abdel; Zada, Suher; Tawab, F M Abdel

    2014-11-01

    MicroRNAs are small 19-25 nucleotides which have been shown to play important roles in the regulation of gene expression in many organisms. Downregulation or accumulation of miRNAs implies either tumor suppression or oncogenic activation. In this study, differentially expressed hsa-miR-195 in hepatocellular carcinoma (HCC) was identified and analyzed. The prediction was done using a consensus approach of tools. The validation steps were done at two different levels in silico and in vitro. FGF7, GHR, PCMT1, CITED2, PEX5, PEX13, NOVA1, AXIN2, and TSPYL2 were detected with high significant (P < 0.005). These genes are involved in important pathways in cancer like MAPK signaling pathway, Jak-STAT signaling pathways, regulation of actin cytoskeleton, angiogenesis, Wnt signaling pathway, and TGF-beta signaling pathway. In vitro target validation was done for protein-L-isoaspartate (D-aspartate) O-methyltransferase (PCMT1). The co-transfection of pmirGLO-PCMT1 and pEGP-miR-195 showed highly significant results. Firefly luciferase was detected using Lumiscensor and t test analysis was done. Firefly luciferase expression was significantly decreased (P < 0.001) in comparison to the control. The low expression of firefly luciferase validates the method of target prediction that we used in this work by working on PCMT1 as a target for miR-195. Furthermore, the rest of the predicted genes are suspected to be real targets for hsa-miR-195. These target genes control almost all the hallmarks of liver cancer which can be used as therapeutic targets in cancer treatment.

  9. 49 CFR 195.581 - Which pipelines must I protect against atmospheric corrosion and what coating material may I use?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the prevention of atmospheric corrosion. (c) Except portions of pipelines in offshore splash zones or... corrosion will— (1) Only be a light surface oxide; or (2) Not affect the safe operation of the pipeline... corrosion and what coating material may I use? 195.581 Section 195.581 Transportation Other Regulations...

  10. 49 CFR 195.581 - Which pipelines must I protect against atmospheric corrosion and what coating material may I use?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... the prevention of atmospheric corrosion. (c) Except portions of pipelines in offshore splash zones or... corrosion will— (1) Only be a light surface oxide; or (2) Not affect the safe operation of the pipeline... corrosion and what coating material may I use? 195.581 Section 195.581 Transportation Other Regulations...

  11. Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion-induced apoptosis through PI3K/Akt/GSK3β pathway in rats.

    PubMed

    Chen, Lin; Wei, Xinbing; Hou, Yunfeng; Liu, Xiaoqian; Li, Senpeng; Sun, Baozhu; Liu, Xinyong; Liu, Huiqing

    2014-01-01

    CXC195 showed strongest protective effects among the ligustrazine derivatives in cells and prevented apoptosis induced by H2O2 injury. We recently demonstrated that CXC195 protected against cerebral ischemia/reperfusion (I/R) injury by its antioxidant activity. However, whether the anti-apoptotic action of CXC195 is involved in cerebral I/R injury is unknown. Here, we investigated the role of CXC195 in apoptotic processes induced by cerebral I/R and the possible signaling pathways. Male Wistar rats were submitted to transient middle cerebral artery occlusion for 2h, followed by 24h reperfusion. CXC195 was injected intraperitoneally at 2h and 12h after the onset of ischemia. The number of apoptotic cells was measured by TUNEL assay, apoptosis-related protein cleaved caspase-3, Bcl-2, Bax and the phosphorylation levels of Akt and GSK3β in ischemic penumbra were assayed by western blot. The results showed that administration of CXC195 at the doses of 3mg/kg and 10mg/kg significantly inhibited the apoptosis by decreasing the number of apoptotic cells, decreasing the level of cleaved caspase-3 and Bax, and increasing the level of Bcl-2 in rats subjected to I/R injury. Simultaneously, CXC195 treatment markedly increased the phosphorylation of Akt and GSK3β. Blockade of PI3K activity by wortmannin, dramatically abolished its anti-apoptotic effect and lowered both Akt and GSK3β phosphorylation levels. Our study firstly demonstrated that CXC195 protected against cerebral I/R injury by reducing apoptosis in vivo and PI3K/Akt/GSK3β pathway involved in the anti-apoptotic effect. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

  12. 49 CFR 173.195 - Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Hydrogen cyanide, anhydrous, stabilized... Hazardous Materials Other Than Class 1 and Class 7 § 173.195 Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution). (a) Hydrogen cyanide, anhydrous, stabilized, must be packed in...

  13. 49 CFR 173.195 - Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Hydrogen cyanide, anhydrous, stabilized... Hazardous Materials Other Than Class 1 and Class 7 § 173.195 Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution). (a) Hydrogen cyanide, anhydrous, stabilized, must be packed in...

  14. 49 CFR 173.195 - Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Hydrogen cyanide, anhydrous, stabilized... Hazardous Materials Other Than Class 1 and Class 7 § 173.195 Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution). (a) Hydrogen cyanide, anhydrous, stabilized, must be packed in...

  15. 49 CFR 173.195 - Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Hydrogen cyanide, anhydrous, stabilized... Hazardous Materials Other Than Class 1 and Class 7 § 173.195 Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution). (a) Hydrogen cyanide, anhydrous, stabilized, must be packed in...

  16. 49 CFR 173.195 - Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Hydrogen cyanide, anhydrous, stabilized... Hazardous Materials Other Than Class 1 and Class 7 § 173.195 Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution). (a) Hydrogen cyanide, anhydrous, stabilized, must be packed in...

  17. 49 CFR Appendix B to Part 195 - Risk-Based Alternative to Pressure Testing Older Hazardous Liquid and Carbon Dioxide Pipelines

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) (Propane, butane, Natural Gas Liquid (NGL), ammonia) Highly toxic (Benzene, high Hydrogen Sulfide content... Hazardous Liquid and Carbon Dioxide Pipelines B Appendix B to Part 195 Transportation Other Regulations... OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pt. 195...

  18. 49 CFR Appendix B to Part 195 - Risk-Based Alternative to Pressure Testing Older Hazardous Liquid and Carbon Dioxide Pipelines

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) (Propane, butane, Natural Gas Liquid (NGL), ammonia) Highly toxic (Benzene, high Hydrogen Sulfide content... Hazardous Liquid and Carbon Dioxide Pipelines B Appendix B to Part 195 Transportation Other Regulations... OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pt. 195...

  19. 49 CFR Appendix B to Part 195 - Risk-Based Alternative to Pressure Testing Older Hazardous Liquid and Carbon Dioxide Pipelines

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) (Propane, butane, Natural Gas Liquid (NGL), ammonia) Highly toxic (Benzene, high Hydrogen Sulfide content... Hazardous Liquid and Carbon Dioxide Pipelines B Appendix B to Part 195 Transportation Other Regulations... OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pt. 195...

  20. 49 CFR Appendix B to Part 195 - Risk-Based Alternative to Pressure Testing Older Hazardous Liquid and Carbon Dioxide Pipelines

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) (Propane, butane, Natural Gas Liquid (NGL), ammonia) Highly toxic (Benzene, high Hydrogen Sulfide content... Hazardous Liquid and Carbon Dioxide Pipelines B Appendix B to Part 195 Transportation Other Regulations... OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pt. 195...

  1. 49 CFR Appendix B to Part 195 - Risk-Based Alternative to Pressure Testing Older Hazardous Liquid and Carbon Dioxide Pipelines

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) (Propane, butane, Natural Gas Liquid (NGL), ammonia) Highly toxic (Benzene, high Hydrogen Sulfide content... Hazardous Liquid and Carbon Dioxide Pipelines B Appendix B to Part 195 Transportation Other Regulations... OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pt. 195...

  2. 41 CFR 102-74.195 - What ventilation policy must Federal agencies follow?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What ventilation policy...-FACILITY MANAGEMENT Facility Management Energy Conservation § 102-74.195 What ventilation policy must Federal agencies follow? During working hours in periods of heating and cooling, Federal agencies must...

  3. 14 CFR 121.195 - Airplanes: Turbine engine powered: Landing limitations: Destination airports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Airplanes: Turbine engine powered: Landing... Performance Operating Limitations § 121.195 Airplanes: Turbine engine powered: Landing limitations: Destination airports. (a) No person operating a turbine engine powered airplane may take off that airplane at...

  4. 14 CFR 121.195 - Airplanes: Turbine engine powered: Landing limitations: Destination airports.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Airplanes: Turbine engine powered: Landing... Performance Operating Limitations § 121.195 Airplanes: Turbine engine powered: Landing limitations: Destination airports. (a) No person operating a turbine engine powered airplane may take off that airplane at...

  5. 49 CFR 37.195 - Purchase or lease of OTRBs by private entities not primarily in the business of transporting people.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... primarily in the business of transporting people. 37.195 Section 37.195 Transportation Office of the... transporting people. This section applies to all purchases or leases of new vehicles by private entities which are not primarily engaged in the business of transporting people, with respect to buses delivered to...

  6. 49 CFR 37.195 - Purchase or lease of OTRBs by private entities not primarily in the business of transporting people.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... primarily in the business of transporting people. 37.195 Section 37.195 Transportation Office of the... transporting people. This section applies to all purchases or leases of new vehicles by private entities which are not primarily engaged in the business of transporting people, with respect to buses delivered to...

  7. 49 CFR 37.195 - Purchase or lease of OTRBs by private entities not primarily in the business of transporting people.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... primarily in the business of transporting people. 37.195 Section 37.195 Transportation Office of the... transporting people. This section applies to all purchases or leases of new vehicles by private entities which are not primarily engaged in the business of transporting people, with respect to buses delivered to...

  8. 49 CFR 37.195 - Purchase or lease of OTRBs by private entities not primarily in the business of transporting people.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... primarily in the business of transporting people. 37.195 Section 37.195 Transportation Office of the... transporting people. This section applies to all purchases or leases of new vehicles by private entities which are not primarily engaged in the business of transporting people, with respect to buses delivered to...

  9. 49 CFR 37.195 - Purchase or lease of OTRBs by private entities not primarily in the business of transporting people.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... primarily in the business of transporting people. 37.195 Section 37.195 Transportation Office of the... transporting people. This section applies to all purchases or leases of new vehicles by private entities which are not primarily engaged in the business of transporting people, with respect to buses delivered to...

  10. 49 CFR 195.585 - What must I do to correct corroded pipe?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.585 What must I do to correct corroded pipe? (a) General corrosion. If you find pipe so generally corroded that the remaining wall thickness... restore the serviceability of the pipe. (b) Localized corrosion pitting. If you find pipe that has...

  11. 49 CFR 195.585 - What must I do to correct corroded pipe?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.585 What must I do to correct corroded pipe? (a) General corrosion. If you find pipe so generally corroded that the remaining wall thickness... restore the serviceability of the pipe. (b) Localized corrosion pitting. If you find pipe that has...

  12. 49 CFR 195.585 - What must I do to correct corroded pipe?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.585 What must I do to correct corroded pipe? (a) General corrosion. If you find pipe so generally corroded that the remaining wall thickness... restore the serviceability of the pipe. (b) Localized corrosion pitting. If you find pipe that has...

  13. 49 CFR 195.585 - What must I do to correct corroded pipe?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.585 What must I do to correct corroded pipe? (a) General corrosion. If you find pipe so generally corroded that the remaining wall thickness... restore the serviceability of the pipe. (b) Localized corrosion pitting. If you find pipe that has...

  14. 49 CFR 195.585 - What must I do to correct corroded pipe?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.585 What must I do to correct corroded pipe? (a) General corrosion. If you find pipe so generally corroded that the remaining wall thickness... restore the serviceability of the pipe. (b) Localized corrosion pitting. If you find pipe that has...

  15. Role of allosteric switch residue histidine 195 in maintaining active-site asymmetry in presynaptic filaments of bacteriophage T4 UvsX recombinase.

    PubMed

    Farb, Joshua N; Morrical, Scott W

    2009-01-16

    Recombinases of the highly conserved RecA/Rad51 family play central roles in homologous recombination and DNA double-stranded break repair. RecA/Rad51 enzymes form presynaptic filaments on single-stranded DNA (ssDNA) that are allosterically activated to catalyze ATPase and DNA strand-exchange reactions. Information is conveyed between DNA- and ATP-binding sites, in part, by a highly conserved glutamine residue (Gln194 in Escherichia coli RecA) that acts as an allosteric switch. The T4 UvsX protein is a divergent RecA ortholog and contains histidine (His195) in place of glutamine at the allosteric switch position. UvsX and RecA catalyze similar strand-exchange reactions, but differ in other properties. UvsX produces both ADP and AMP as products of its ssDNA-dependent ATPase activity--a property that is unique among characterized recombinases. Details of the kinetics of ssDNA-dependent ATP hydrolysis reactions indicate that UvsX-ssDNA presynaptic filaments are asymmetric and contain two classes of ATPase active sites: one that generates ADP, and another that generates AMP. Active-site asymmetry is reduced by mutations at the His195 position, since UvsX-H195Q and UvsX-H195A mutants both exhibit stronger ssDNA-dependent ATPase activity, with lower cooperativity and markedly higher ADP/AMP product ratios, than wild-type UvsX. Reduced active-site asymmetry correlates strongly with reduced ssDNA-binding affinity and DNA strand-exchange activity in both H195Q and H195A mutants. These and other results support a model in which allosteric switch residue His195 controls the formation of an asymmetric conformation of UvsX-ssDNA filaments that is active in DNA strand exchange. The implications of our findings for UvsX recombination functions, and for RecA functions in general, are discussed.

  16. miR-195 inhibited abnormal activation of osteoblast differentiation in MC3T3-E1 cells via targeting RAF-1.

    PubMed

    Chao, Chen; Li, Feng; Tan, Zhiping; Zhang, Weizhi; Yang, Yifeng; Luo, Cheng

    2018-01-15

    Recent reports have demonstrated that RAF-1 L613V (a mutant of RAF-1) mutant mice show bone deformities similar to Noonan syndrome. It has been suggested that RAF-1 L613V might abnormally activate osteoblast differentiation of MC3T3-E1 cells. To demonstrate that RAF-1 is associated with bone deformity and that RAF-1 L613V dependent bone deformity could be inhibited by microRNA-195 (miR-195), we first investigated the amplifying influence of wild-type RAF-1 (WT) or RAF-1 L613V (L613V) on the viability and differentiation of MC3T3-E1 cells induced by bone morphogenetic protein-2 (BMP-2) via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, alkaline phosphatase (ALP) and Alizarin Red S (ARS) staining, quantitative real-time polymerase chain reaction (qRT-PCR) and western blot analysis. Subsequently, we investigated the blocking effect and its mechanism of miR-195 for abnormal activation of osteoblast differentiation of MC3T3-E1 cells via targeting RAF-1. RAF-1, especially RAF-1 L613V , abnormally activates osteoblast differentiation of MC3T3-E1 cells induced by BMP-2. Meanwhile, miR-195 could inhibit the cell viability and differentiation of MC3T3-E1 cells. Transfection of miR-195 largely suppressed the L613V-induced viability and osteoblast differentiation of MC3T3-E1 cells and attenuated the accelerative effect of L613V on runt-related transcription factor-2 (Runx2), Osterix (OSX), alkaline phosphatase (ALP), osteocalcin (OCN), and distal-less homeobox 5 (DLX5) osteogenic gene expressions. In addition, miR-195 decreased the expression of RAF-1 mRNA and protein by directly targeting the 3'-untranslated regions (3'-UTR) of RAF-1 mRNA in MC3T3-E1 cells. Our findings indicated that miR-195 inhibited WT and L613V RAF-1 induced hyperactive osteoblast differentiation in MC3T3-E1 cells by targeting RAF-1. miR-195 might be a novel therapeutic agent for the treatment of L613V-induced bone deformity in Noonan syndrome. Copyright © 2017. Published by

  17. Histidine at Position 195 is Essential for Association of Heme-b in Lcp1VH2

    NASA Astrophysics Data System (ADS)

    Oetermann, Sylvia; Vivod, Robin; Hiessl, Sebastian; Hogeback, Jens; Holtkamp, Michael; Karst, Uwe; Steinbüchel, Alexander

    2018-03-01

    The latex clearing protein (Lcp) is the key enzyme of polyisoprene degradation in actinomycetes (Yikmis and Steinbüchel in Appl Environ Microbiol 78:4543-4551, https://doi.org/10.1128/AEM.00001-12, 2012). In this study it was shown that Lcp from Gordonia polyisoprenivorans VH2 (Lcp1VH2) harbors a non-covalently bound heme b as cofactor, which was identified by pyridine hemochrome spectra and confirmed by LC/ESI-ToF-MS. It contains iron, most likely in the Fe3+ state. We focused on the characterization of the heme-cofactor, its accessibility with respect to the conformation of Lcp1VH2, and the identification of putative histidine residues involved in the coordination of heme. A change was detectable in UV/Vis-spectra of reduced Lcp1VH2 when imidazole was added, showing that Lcp1VH2 "as isolated" occurs in an open state, directly being accessible for external ligands. In addition, three highly conserved histidines (H195, H200 and H228), presumably acting as ligands coordinating the heme within the heme pocket, were replaced with alanines by site-directed mutagenesis. The effect of these changes on in vivo rubber-mineralization was investigated. The lcp- deletion mutant complemented with the H195A variant of lcp1 VH2 was unable to mineralize poly(cis-1,4-isoprene). In vitro analyses of purified, recombinant Lcp1VH2H195A confirmed the loss of enzyme activity, which could be ascribed to the loss of heme. Hence, H195 is essential for the association of heme-b in the central region of Lcp1VH2.

  18. 32 CFR Appendix A to Part 195 - Programs to Which This Part Applies

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Programs to Which This Part Applies A Appendix A to Part 195 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OF THE DEPARTMENT OF DEFENSE...

  19. 32 CFR Appendix A to Part 195 - Programs to Which This Part Applies

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Programs to Which This Part Applies A Appendix A to Part 195 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OF THE DEPARTMENT OF DEFENSE...

  20. 32 CFR Appendix A to Part 195 - Programs to Which This Part Applies

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Programs to Which This Part Applies A Appendix A to Part 195 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OF THE DEPARTMENT OF DEFENSE...

Some links on this page may take you to non-federal websites. Their policies may differ from this site.