Adenovirus-Mediated p202 Gene Transfer in Breast Cancer Gene Therapy
2005-05-01
transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis (1, 3, 4). Our previous studies have shown that p202...leads to induction of p53 and activation of p53 target gene (e.g., p21 CIP 1). 10. The positive regulation of p53 by IFIXcd can be observed only in...cancers. Together, our data suggest that both Ad-p202 and IFIX may be further developed into efficient therapeutic agents for human cancer gene
Shi, Xiao-Jing; Ding, Lina; Zhou, Wenjuan; Ji, Yage; Wang, Junwei; Wang, Huimin; Ma, Yongcheng; Jiang, Guozhong; Tang, Kai
2017-01-01
Abstract Aims: Esophageal cancer (EC) is an aggressive malignancy and the most common solid tumor of gastrointestinal tract all over the world, with high incidence in Asia. The current study was designed to investigate the anticancer efficacy and mechanism that is involved in the action of a natural ent-kaurene diterpenoid, JDA-202, targeting EC. Results: We found that an antioxidant protein peroxiredoxin I (Prx I) was upregulated in human EC tissues as well as in EC cell lines. JDA-202, a novel natural compound isolated from Isodon rubescens (Labiatae), was proved to possess strong anti-proliferative activities on those cell lines. Importantly, JDA-202 does not only bind to Prx I directly and markedly inhibit the activity of Prx I in vitro, but it also significantly induces hydrogen peroxide (H2O2)-related cell death. Furthermore, overexpression of Prx I significantly reversed EC109 cell apoptosis caused by JDA-202, whereas short interfering RNA (siRNA)-induced Prx I knockdown resulted in marked cell death even without JDA-202 pretreatment. On the other hand, the increased phosphorylation of mitogen-activated protein kinase (MAPK) proteins (c-Jun N-terminal kinase [JNK], p38, and extracellular signal-regulated kinase [ERK]) by JDA-202 was suppressed by N-acetylcysteine (NAC) or catalase, a known reactive oxygen species (ROS) or H2O2 scavenger. JDA-202 also significantly inhibited the growth of EC109 tumor xenograft, without significant body weight loss and multi-organ toxicities. Innovation and Conclusion: Our findings, for the first time, demonstrated that JDA-202 may serve as a lead compound, targeting the overexpressed Prx I in EC cell lines and ROS accumulation as well as inhibiting the activation of their downstream targets in MAPKs. Antioxid. Redox Signal. 27, 73–92. PMID:27650197
Hassan, Mubashir; Abbas, Qamar; Raza, Hussain; Moustafa, Ahmed A; Seo, Sung-Yum
2017-07-25
Misfolding and structural alteration in proteins lead to serious malfunctions and cause various diseases in humans. Mutations at the active binding site in tyrosinase impair structural stability and cause lethal albinism by abolishing copper binding. To evaluate the histidine mutational effect, all mutated structures were built using homology modelling. The protein sequence was retrieved from the UniProt database, and 3D models of original and mutated human tyrosinase sequences were predicted by changing the residual positions within the target sequence separately. Structural and mutational analyses were performed to interpret the significance of mutated residues (N 180 , R 202 , Q 202 , R 211 , Y 363 , R 367 , Y 367 and D 390 ) at the active binding site of tyrosinases. CSpritz analysis depicted that 23.25% residues actively participate in the instability of tyrosinase. The accuracy of predicted models was confirmed through online servers ProSA-web, ERRAT score and VERIFY 3D values. The theoretical pI and GRAVY generated results also showed the accuracy of the predicted models. The CCA negative correlation results depicted that the replacement of mutated residues at His within the active binding site disturbs the structural stability of tyrosinases. The predicted CCA scores of Tyr 367 (-0.079) and Q/R 202 (0.032) revealed that both mutations have more potential to disturb the structural stability. MD simulation analyses of all predicted models justified that Gln 202 , Arg 202 , Tyr 367 and D 390 replacement made the protein structures more susceptible to destabilization. Mutational results showed that the replacement of His with Q/R 202 and Y/R 363 has a lethal effect and may cause melanin associated diseases such as OCA1. Taken together, our computational analysis depicts that the mutated residues such as Q/R 202 and Y/R 363 actively participate in instability and misfolding of tyrosinases, which may govern OCA1 through disturbing the melanin biosynthetic pathway.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Civil rights. 31.202 Section 31.202....202 Civil rights. (a) To carry out the State's Federal civil rights responsibilities the plan must: (1) Designate a civil rights contact person who has lead responsibility in insuring that all applicable civil...
Code of Federal Regulations, 2014 CFR
2014-07-01
... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Civil rights. 31.202 Section 31.202....202 Civil rights. (a) To carry out the State's Federal civil rights responsibilities the plan must: (1) Designate a civil rights contact person who has lead responsibility in insuring that all applicable civil...
Code of Federal Regulations, 2013 CFR
2013-07-01
... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Civil rights. 31.202 Section 31.202....202 Civil rights. (a) To carry out the State's Federal civil rights responsibilities the plan must: (1) Designate a civil rights contact person who has lead responsibility in insuring that all applicable civil...
Code of Federal Regulations, 2011 CFR
2011-07-01
... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Civil rights. 31.202 Section 31.202....202 Civil rights. (a) To carry out the State's Federal civil rights responsibilities the plan must: (1) Designate a civil rights contact person who has lead responsibility in insuring that all applicable civil...
Code of Federal Regulations, 2010 CFR
2010-07-01
... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Civil rights. 31.202 Section 31.202....202 Civil rights. (a) To carry out the State's Federal civil rights responsibilities the plan must: (1) Designate a civil rights contact person who has lead responsibility in insuring that all applicable civil...
Deng, Yingjun; Li, Xin; Feng, Jinxin; Zhang, Xiangliang
2018-01-01
Chronic myeloid leukemia (CML) is a myeloproliferative disease which uniquely expresses a constitutively active tyrosine kinase, BCR/ABL. As a specific inhibitor of the BCR-ABL tyrosine kinase, imatinib becomes the first choice for the treatment of CML due to its high efficacy and low toxicity. However, the development of imatinib resistance limits the long-term treatment benefits of it in CML patients. In the present study, we aimed to investigate the roles of miR-202 in the regulation of imatinib sensitivity in CML cell lines and the possible mechanisms involved in this process. We found miR-202 was down-regulated in seven CML cell lines by quantitative reverse-transcription PCR (qRT-PCR) analysis. Overexpression of miR-202 significantly suppressed proliferation rates of CML cells. By establishing imatinib resistant cell lines originating from K562 and KU812 cells, we observed expressions of miR-202 were down-regulated by imatinib treatments and imatinib resistant CML cell lines exhibited lower level of miR-202. On the contrary, imatinib resistant CML cell lines displayed up-regulated glycolysis rate than sensitive cells with the evidence that glucose uptake, lactate production, and key glycolysis enzymes were elevated in imatinib resistant cells. Importantly, the imatinib resistant CML cell lines were more sensitive to glucose starvation and glycolysis inhibitors. In addition, we identified Hexokinase 2 (HK2) as a direct target of miR-202 in CML cell lines. Overexpression of miR-202 sensitized imatinib resistant CML through the miR-202-mediated glycolysis inhibition by targetting HK2. Finally, we provided the clinical relevance that miR-202 was down-regulated in CML patients and patients with lower miR-202 expression displayed higher HK2 expression. The present study will provide new aspects on the miRNA-modulated tyrosine kinase inhibitor (TKI) sensitivity in CML, contributing to the development of new therapeutic anticancer drugs. PMID:29559564
DOE Office of Scientific and Technical Information (OSTI.GOV)
Meng, Xiangrui, E-mail: xiangruimengzz@163.com; Chen, Xiaoqi; Lu, Peng
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignancies in the gastrointestinal tract. Emerging studies have indicated that microRNAs (miRNAs) are strongly implicated in the development and progression of ESCC. Here, we focused on the function and the underlying molecular mechanism of miR-202 in ESCC. The results showed that miR-202 was significantly down-regulated in ESCC tissues and cell lines. Overexpression of miR-202 in ECa-109 and KYSE-510 cells markedly suppressed cell proliferation and cell migration, and induced cell apoptosis. Furthermore, laminin α1 (LAMA1) expression was frequently positive in ESCC tissues and inversely correlated with miR-202 expression. Then we demonstratedmore » that miR-202 targeted 3'-untranslated region (UTR) of LAMA1 and inhibited its protein expression. Additionally, LAMA1 overexpression rescued the proliferation inhibition and cell apoptosis elevation induced by miR-202. MiR-202 also inhibited the protein expression of p-FAK and p-Akt, which were all reversed by LAMA1 overexpression. Taken together, these findings suggest that miR-202 may function as a novel tumor suppressor in ESCC by repressing cell proliferation and migration, and its biological effects may attribute the inhibition of LAMA1-mediated FAK-PI3K-Akt signaling. - Highlights: • Expression of miR-202 was decreased in ESCC tissues and cell lines. • MiR-202 overexpression inhibited ESCC cell growth and induced apoptosis. • MiR-202 directly targeted LAMA1 in ESCC. • The LAMA1-FAK-PI3K signaling mediated the suppressive role of miR-202.« less
49 CFR 325.7 - Allowable noise levels.
Code of Federal Regulations, 2010 CFR
2010-10-01
... distance between the microphone location point and the microphone target point is— 31 ft ( 9.5m) or more... is based on motor carrier noise emission requirements specified in 40 CFR 202.20 and 40 CFR 202.21...
Neutron production for 250 MeV protons bombarding on thick grain-made tungsten target
NASA Astrophysics Data System (ADS)
Zhang, Xueying; Zhang, Yanbin; Ma, Fei; Ju, Yongqin; Chen, Liang; Zhang, Hongbin; Li, Yanyan; Wan, Bo; Wang, Jianguo; Ge, Honglin
2015-08-01
Neutron yield for 250 MeV protons incident on a tungsten target has been measured using the water bath method. The target was made of many randomly placed tungsten grains. Through analyzing the activity of Au foils, the neutron flux distribution in water was obtained. The neutrons slowing down process shows that the neutrons from tungsten have an average energy lower than neutrons from the lead target. The neutron yield was experimentally determined to be 2.02 ± 0.15 neutron/proton. Detailed simulation was also performed with the Geant4 toolkit. Comparison has been made with the experimentally derived neutron yield. It was found that, around 250 MeV, experimental results were described satisfactorily with a combination of high-energy spallation, low-energy neutron reaction and scattering. It was shown that the grain-packed target does not affect much the main neutronic properties, which are of crucial importance for the design of the spallation target.
Chen, Jian; Cai, Tanxi; Zheng, Chunwei; Lin, Xiwen; Wang, Guojun; Liao, Shangying; Wang, Xiuxia; Gan, Haiyun; Zhang, Daoqin; Hu, Xiangjing; Wang, Si; Li, Zhen; Feng, Yanmin
2017-01-01
Abstract miRNAs play important roles during mammalian spermatogenesis. However, the function of most miRNAs in spermatogenesis and the underlying mechanisms remain unknown. Here, we report that miR-202 is highly expressed in mouse spermatogonial stem cells (SSCs), and is oppositely regulated by Glial cell-Derived Neurotrophic Factor (GDNF) and retinoic acid (RA), two key factors for SSC self-renewal and differentiation. We used inducible CRISPR-Cas9 to knockout miR-202 in cultured SSCs, and found that the knockout SSCs initiated premature differentiation accompanied by reduced stem cell activity and increased mitosis and apoptosis. Target genes were identified with iTRAQ-based proteomic analysis and RNA sequencing, and are enriched with cell cycle regulators and RNA-binding proteins. Rbfox2 and Cpeb1 were found to be direct targets of miR-202 and Rbfox2 but not Cpeb1, is essential for the differentiation of SSCs into meiotic cells. Accordingly, an SSC fate-regulatory network composed of signaling molecules of GDNF and RA, miR-202 and diverse downstream effectors has been identified. PMID:27998933
Kydd, Anna C; Khan, Fakhar Z; Watson, William D; Pugh, Peter J; Virdee, Munmohan S; Dutka, David P
2014-06-01
This study was conducted to assess the impact of left ventricular (LV) lead position on longer-term survival after cardiac resynchronization therapy (CRT). An optimal LV lead position in CRT is associated with improved clinical outcome. A strategy of speckle-tracking echocardiography can be used to guide the implanter to the site of latest activation and away from segments of low strain amplitude (scar). Long-term, prospective survival data according to LV lead position in CRT are limited. Data from a follow-up registry of 250 consecutive patients receiving CRT between June 2008 and July 2010 were studied. The study population comprised patients recruited to the derivation group and the subsequent TARGET (Targeted Left Ventricular Lead Placement to guide Cardiac Resynchronization Therapy) randomized, controlled trial. Final LV lead position was described, in relation to the pacing site determined by pre-procedure speckle-tracking echocardiography, as optimal (concordant/adjacent) or suboptimal (remote). All-cause mortality was recorded at follow-up. An optimal LV lead position (n = 202) conferred LV remodeling response superior to that of a suboptimal lead position (change in LV end-systolic volume: -24 ± 15% vs. -12 ± 17% [p < 0.001]; change in ejection fraction: +7 ± 8% vs. +4 ± 7% [p = 0.02]). During long-term follow-up (median: 39 months; range: <1 to 61 months), an optimal LV lead position was associated with improved survival (log-rank p = 0.003). A suboptimal LV lead placement independently predicted all-cause mortality (hazard ratio: 1.8; p = 0.024). An optimal LV lead position at the site of latest mechanical activation, avoiding low strain amplitude (scar), was associated with superior CRT response and improved survival that persisted during follow-up. Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
DOE Office of Scientific and Technical Information (OSTI.GOV)
D'Ambrosio, Steven M.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210; Han, Chunhua
2011-06-10
Highlights: {yields} The aliphatic acetogenins [(2S,4S)-2,4-dihydroxyheptadec-16-enyl acetate] (1) and [(2S,4S)-2,4-dihydroxyheptadec-16-ynyl acetate] (2) isolated from avocado fruit inhibit phosphorylation of c-RAF (Ser338) and ERK1/2 (Thr202/Tyr204). {yields} Aliphatic acetogenin 2, but not 1, prevents EGF-induced activation of EGFR (Tyr1173). {yields} Combination of both aliphatic acetogenins synergistically inhibits c-RAF (Ser338) and ERK1/2 (Thr202/Tyr204) phosphorylation and human oral cancer cell proliferation. {yields} The potential anticancer activity of avocado fruits is due to a combination of specific aliphatic acetogenins targeting two key components of the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway. {yields} Providing a double hit on a critical cancer pathway such as EGFR/RAS/RAF/MEK/ERK1/2 by phytochemicals like thosemore » found in avocado fruit could lead to more effective approach toward cancer prevention. -- Abstract: Avocado (Persea americana) fruits are consumed as part of the human diet and extracts have shown growth inhibitory effects in various types of human cancer cells, although the effectiveness of individual components and their underlying mechanism are poorly understood. Using activity-guided fractionation of the flesh of avocado fruits, a chloroform-soluble extract (D003) was identified that exhibited high efficacy towards premalignant and malignant human oral cancer cell lines. From this extract, two aliphatic acetogenins of previously known structure were isolated, compounds 1 [(2S,4S)-2,4-dihydroxyheptadec-16-enyl acetate] and 2 [(2S,4S)-2,4-dihydroxyheptadec-16-ynyl acetate]. In this study, we show for the first time that the growth inhibitory efficacy of this chloroform extract is due to blocking the phosphorylation of EGFR (Tyr1173), c-RAF (Ser338), and ERK1/2 (Thr202/Tyr204) in the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway. Compounds 1 and 2 both inhibited phosphorylation of c-RAF (Ser338) and ERK1/2 (Thr202/Tyr204). Compound 2, but not compound 1, prevented EGF-induced activation of the EGFR (Tyr1173). When compounds 1 and 2 were combined they synergistically inhibited c-RAF (Ser338) and ERK1/2 (Thr202/Tyr204) phosphorylation, and human oral cancer cell proliferation. The present data suggest that the potential anticancer activity of avocado fruits is due to a combination of specific aliphatic acetogenins that target two key components of the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway.« less
Cuadros, Camilo; Dominguez, Ana Lucia; Frost, Gregory I; Borgstrom, Per; Lustgarten, Joseph
2003-09-15
Immunotherapy is an attractive strategy for cancer treatment. However, self-tolerance is one of the major mechanisms that dampen immune responses against self-tumor antigens. We have demonstrated that Her-2/neu transgenic mice (neu mice) are tolerant to neu antigens and contain only a low avidity repertoire for neu. However, this repertoire has antitumor activity. Immunizations of neu mice are capable of activating the low-avidity T cells that, at best, retard the tumor growth. To increase the efficacy of the antitumor responses in neu mice, we hypothesized that immunotherapy in combination with antiangiogenic therapy would be a more efficient strategy for tumor eradication. The rationale for using this combination was that by decreasing the growth rate of the tumor with an antiangiogenic therapy, the low-avidity repertoire of neu mice stimulated by immunotherapeutic intervention would be more effective in destroying the slow growing tumor. To test this hypothesis, we stably expressed a soluble form of the Flt-1 vascular endothelial growth factor receptor (sFlt-1) on N202.1A cells, using a retrovirus vector. Expression of sFlt-1 on N202.1A (N202-Flt) cells significantly inhibited the tumor growth compared with N202.1A parental cells. In contrast to the application of immunotherapy alone or antiangiogenic therapy alone, which delayed the tumor growth, the combination of the two therapies provided complete inhibition of tumor growth in Her-2/neu mice. These results indicate that the use of tumor targeting with immunotherapy in simultaneous combination with antiangiogenic therapy provides a more efficient strategy for the treatment of solid tumors.
Federal Register 2010, 2011, 2012, 2013, 2014
2010-04-26
... Black Lake Blvd. SW., Suite B, Olympia, WA 98512, (360) 704-7762, [email protected] West Virginia... USDA's TARGET Center at (202) 720-2600 (voice and TDD). To file a complaint of discrimination, write to... call (800) 795-3272 (voice), or (202) 720-6382 (TDD). ``USDA is an equal opportunity provider, employer...
Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-03
... Rural Development State Office, 1835 Black Lake Boulevard SW., Suite B, Olympia, WA 98512-5715, (360... TARGET Center at (202) 720-2600 (voice and TDD). To file a complaint of discrimination write to USDA... or call (800) 795-3272 (voice) or (202) 720-6382 (TDD). USDA is an equal opportunity provider...
DOE Office of Scientific and Technical Information (OSTI.GOV)
Fu, Meili, E-mail: fumeilidrlinyi@tom.com; Wan, Fuqiang; Li, Zhengling
The aim of the present study is to investigate the potential anti-hepatocellular carcinoma (HCC) cell activity by 4SC-202, a novel class I HDAC inhibitor (HDACi). The associated signaling mechanisms were also analyzed. We showed that 4SC-202 treatment induced potent cytotoxic and proliferation–inhibitory activities against established HCC cell lines (HepG2, HepB3, SMMC-7721) and patient-derived primary HCC cells. Further, adding 4SC-202 in HCC cells activated mitochondrial apoptosis pathway, which was evidenced by mitochondrial permeability transition pore (mPTP) opening, cytochrome C cytosol release and caspase-3/-9 activation. Inhibition of this apoptosis pathway, by caspase-3/-9 inhibitors, mPTP blockers, or by shRNA-mediated knockdown of cyclophilin-D (Cyp-D,more » a key component of mPTP), significantly attenuated 4SC-202-induced HCC cell death and apoptosis. Reversely, over-expression of Cyp-D enhanced 4SC-202's sensitivity in HCC cells. Further studies showed that 4SC-202 induced apoptosis signal-regulating kinase 1 (ASK1) activation, causing it translocation to mitochondria and physical association with Cyp-D. This mitochondrial ASK1-Cyp-D complexation appeared required for mediating 4SC-202-induced apoptosis activation. ASK1 stable knockdown by targeted-shRNAs largely inhibited 4SC-202-induced mPTP opening, cytochrome C release, and following HCC cell apoptotic death. Together, we suggest that 4SC-202 activates ASK1-dependent mitochondrial apoptosis pathway to potently inhibit human HCC cells. - Highlights: • 4SC-202 exerts potent anti-proliferative and cytotoxic activity against established/primary HCC cells. • SC-202-induced anti-HCC cell activity relies on caspase-dependent apoptosis activation. • 4SC-202 activates Cyp-D-dependent mitochondrial apoptosis pathway in HCC cells. • 4SC-202 activates ASK1 in HCC cells, causing it translocation to mitochondria. • Mitochondrial ASK1-Cyp-D complexation mediates 4SC-202's activity in HCC cells.« less
Federal Register 2010, 2011, 2012, 2013, 2014
2010-04-27
... 23229 (804) 287-1596 TDD (804) 287-1753 CJ Michels Washington State Office 1835 Black Lake Boulevard... (202) 690-0759 (voice) (this is not a toll free number) or (800) 877-8339 (TDD-Federal Information... USDA's TARGET Center at (202) 720-2600 (voice and TDD). To file a complaint of discrimination, write to...
Federal Register 2010, 2011, 2012, 2013, 2014
2011-04-14
... Florida) Washington Mary Traxler, USDA Rural Development, 1835 Black Lake Blvd. SW., Suite B, Olympia, WA... USDA's TARGET Center at (202) 720-2600 (voice and TDD). To file a complaint of discrimination write to... 20250-9410 or call (800) 795-3272 (voice) or (202) 720- 6382 (TDD). USDA is an equal opportunity...
Denmeade, Samuel R; Mhaka, Annastasiah M; Rosen, D Marc; Brennen, W Nathaniel; Dalrymple, Susan; Dach, Ingrid; Olesen, Claus; Gurel, Bora; Demarzo, Angelo M; Wilding, George; Carducci, Michael A; Dionne, Craig A; Møller, Jesper V; Nissen, Poul; Christensen, S Brøgger; Isaacs, John T
2012-06-27
Heterogeneous expression of drug target proteins within tumor sites is a major mechanism of resistance to anticancer therapies. We describe a strategy to selectively inhibit, within tumor sites, the function of a critical intracellular protein, the sarcoplasmic/endoplasmic reticulum calcium adenosine triphosphatase (SERCA) pump, whose proper function is required by all cell types for viability. To achieve targeted inhibition, we took advantage of the unique expression of the carboxypeptidase prostate-specific membrane antigen (PSMA) by tumor endothelial cells within the microenvironment of solid tumors. We generated a prodrug, G202, consisting of a PSMA-specific peptide coupled to an analog of the potent SERCA pump inhibitor thapsigargin. G202 produced substantial tumor regression against a panel of human cancer xenografts in vivo at doses that were minimally toxic to the host. On the basis of these data, a phase 1 dose-escalation clinical trial has been initiated with G202 in patients with advanced cancer.
Clinical evaluation of R202Q alteration of MEFV genes in Turkish children.
Comak, Elif; Akman, Sema; Koyun, Mustafa; Dogan, Cagla Serpil; Gokceoglu, Arife Uslu; Arikan, Yunus; Keser, Ibrahim
2014-12-01
To date, over 200 alterations have been reported in Mediterranean fever (MEFV) genes, but it is not clear whether all these alterations are disease-causing mutations. This study aims to evaluate the clinical features of the children with R202Q alteration. The medical records of children with R202Q alteration were reviewed retrospectively. A total of 225 children, with 113 males, were included. Fifty-five patients were heterozygous, 30 patients were homozygous for R202Q, and 140 patients were compound heterozygous. Classical familial Mediterranean fever (FMF) phenotype was present in 113 patients: 2 heterozygous and 7 homozygous R202Q, 46 double homozygous R202Q and M694V, and 58 compound heterozygous. The main clinical characteristics of the patients were abdominal pain in 71.5 %, fever in 37.7 %, arthralgia/myalgia in 30.2 %, arthritis in 10.2 %, chest pain in 14.6 % and erysipelas-like erythema in 13.3 %. The frequency of abdominal pain was significantly lower in patients with homozygous R202Q alteration (p = 0.021), whereas patients with heterozygous R202Q mutations, though not statistically significant, had a higher frequency of arthralgia/myalgia (40.0 %, p = 0.05). R202Q alteration of the MEFV gene leads to symptoms consistent with FMF in some cases. This alteration may be associated with a mild phenotype and shows phenotypic differences other than the common MEFV mutations.
Miller, Nimrod; Feng, Zhihua; Edens, Brittany M.; Yang, Ben; Shi, Han; Sze, Christie C.; Hong, Benjamin Taige; Su, Susan C.; Cantu, Jorge A.; Topczewski, Jacek; Crawford, Thomas O.; Ko, Chien-Ping; Sumner, Charlotte J.; Ma, Long
2015-01-01
Mechanisms underlying motor neuron degeneration in spinal muscular atrophy (SMA), the leading inherited cause of infant mortality, remain largely unknown. Many studies have established the importance of hyperphosphorylation of the microtubule-associated protein tau in various neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. However, tau phosphorylation in SMA pathogenesis has yet to be investigated. Here we show that tau phosphorylation on serine 202 (S202) and threonine 205 (T205) is increased significantly in SMA motor neurons using two SMA mouse models and human SMA patient spinal cord samples. Interestingly, phosphorylated tau does not form aggregates in motor neurons or neuromuscular junctions (NMJs), even at late stages of SMA disease, distinguishing it from other tauopathies. Hyperphosphorylation of tau on S202 and T205 is mediated by cyclin-dependent kinase 5 (Cdk5) in SMA disease condition, because tau phosphorylation at these sites is significantly reduced in Cdk5 knock-out mice; genetic knock-out of Cdk5 activating subunit p35 in an SMA mouse model also leads to reduced tau phosphorylation on S202 and T205 in the SMA;p35−/− compound mutant mice. In addition, expression of the phosphorylation-deficient tauS202A,T205A mutant alleviates motor neuron defects in a zebrafish SMA model in vivo and mouse motor neuron degeneration in culture, whereas expression of phosphorylation-mimetic tauS202E,T205E promotes motor neuron defects. More importantly, genetic knock-out of tau in SMA mice rescues synapse stripping on motor neurons, NMJ denervation, and motor neuron degeneration in vivo. Altogether, our findings suggest a novel mechanism for SMA pathogenesis in which hyperphosphorylation of non-aggregating tau by Cdk5 contributes to motor neuron degeneration. PMID:25878277
Ribozyme Targeting the Novel Fusion Junction of EGFRvIII in Breast Cancer
2003-07-01
targeting the novel junction of EGFRvyII. * Demonstrate the therapeutic efficacy of an anti-EGFRvIll hammerhead ribozyme targeting the endogenous...first demonstration of the therapeutic efficacy of an anti-EGFRvlII hammerhead ribozyme targeting the endogenous EGFRvAII expression against human...202-687-7505.designed and generated a tumor specific hammerhead ribozyme E-mail: Tangc@georgetown.edu targeted to the novel fusion junction of
Reversal of collapsing glomerulopathy in mice with the cyclin-dependent kinase inhibitor CYC202.
Gherardi, Dana; D'Agati, Vivette; Chu, Te-Hua Tearina; Barnett, Anna; Gianella-Borradori, Athos; Gelman, Irwin H; Nelson, Peter J
2004-05-01
Collapsing glomerulopathy (CG) has become an important cause of end-stage renal disease. Whether associated with HIV-1 or other potential etiologies, the pathogenesis of CG converges to induce aberrant proliferation of renal epithelium along the entire nephron. This raises the possibility that targeting cell-cycle progression may be an effective therapeutic strategy for CG. Here, we ask whether the cyclin-dependent kinase (CDK) inhibitor, CYC202 (R-roscovitine), could attenuate or reverse existing renal disease in Tg26 mice, a well characterized HIV-1 transgenic mouse model of CG. Tg26 mice were age and disease matched through analysis of urine (protein/creatinine) to generate 12 treatment pairs covering a range of mild to severe CG. One mouse from each pair received either vehicle or 75 mg/kg of CYC202 every 12 h for 20 d, a dose 20% above that needed to prevent the development of CG. After treatment, urinary, serologic, and histopathologic indices of nephrosis showed reversal of CG in 8 of 12 CYC202-treated mice compared with progression of CG in 10 of 12 vehicle-treated mice, demonstrating a significant therapeutic benefit from CYC202 (P < 0.05). Pharmacokinetic profiles showed that concentrations of CYC202 known to inhibit cell-cycle and transcriptional CDK in vitro were achieved in plasma at efficacious doses. However, amelioration of CG by CYC202 did not correlate with decreases in kidney HIV-1 transgene expression, indicating that suppression of HIV-1 transcription was not a prerequisite for the antiproliferative activity of CYC202. These results demonstrate a novel therapeutic strategy for CG.
Study of isomeric states in 198,200,202,206Pb and 206Hg populated in fragmentation reactions
NASA Astrophysics Data System (ADS)
Lalović, N.; Rudolph, D.; Podolyák, Zs; Sarmiento, L. G.; Simpson, E. C.; Alexander, T.; Cortés, M. L.; Gerl, J.; Golubev, P.; Ameil, F.; Arici, T.; Bauer, Ch; Bazzacco, D.; Bentley, M. A.; Boutachkov, P.; Bowry, M.; Fahlander, C.; Gadea, A.; Gellanki, J.; Givechev, A.; Goel, N.; Górska, M.; Gottardo, A.; Gregor, E.; Guastalla, G.; Habermann, T.; Hackstein, M.; Jungclaus, A.; Kojouharov, I.; Kumar, R.; Kurz, N.; Lettmann, M.; Lizarazo, C.; Louchart, C.; Merchán, E.; Michelagnoli, C.; Moeller, Th; Moschner, K.; Patel, Z.; Pietralla, N.; Pietri, S.; Ralet, D.; Reese, M.; Regan, P. H.; Reiter, P.; Schaffner, H.; Singh, P.; Stahl, C.; Stegmann, R.; Stezowski, O.; Taprogge, J.; Thöle, P.; Wendt, A.; Wieland, O.; Wilson, E.; Wood, R.; Wollersheim, H.-J.; Birkenbach, B.; Bruyneel, B.; Burrows, I.; Clément, E.; Désesquelles, P.; Domingo-Pardo, C.; Eberth, J.; González, V.; Hess, H.; Jolie, J.; Judson, D. S.; Menegazzo, R.; Mengoni, D.; Napoli, D. R.; Pullia, A.; Quintana, B.; Rainovski, G.; Salsac, M. D.; Sanchis, E.; Simpson, J.; Valiente Dóbon, J. J.; AGATA Collaboration
2018-03-01
Isomeric states in isotopes in the vicinity of doubly-magic 208Pb were populated following reactions of a relativistic 208Pb primary beam impinging on a 9Be fragmentation target. Secondary beams of 198,200,202,206Pb and 206Hg were isotopically separated and implanted in a passive stopper positioned in the focal plane of the GSI Fragment Separator. Delayed γ rays were detected with the Advanced Gamma Tracking Array (AGATA). Decay schemes were re-evaluated and interpreted with shell-model calculations. The momentum-dependent population of isomeric states in the two-nucleon hole nuclei 206Pb/206Hg was found to differ from the population of multi neutron-hole isomeric states in 198,200,202Pb.
76 FR 40677 - Farm Service Agency
Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-11
... following methods: Mail: Judy Fry, Agricultural Marketing Specialist, Commodity Operations Division, Farm..., large print, audiotape, etc.) should contact USDA's TARGET Center at (202) 720-2600 (voice and TDD...
77 FR 30928 - Target Date Disclosure
Federal Register 2010, 2011, 2012, 2013, 2014
2012-05-24
..., Employee Benefits Security Administration, (202) 693-8500. This is not a toll-free number. SUPPLEMENTARY... and that participants and beneficiaries may lose money by investing in the TDF, including losses near...
An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people
Nelson, Matthew R.; Wegmann, Daniel; Ehm, Margaret G.; Kessner, Darren; St. Jean, Pamela; Verzilli, Claudio; Shen, Judong; Tang, Zhengzheng; Bacanu, Silviu-Alin; Fraser, Dana; Warren, Liling; Aponte, Jennifer; Zawistowski, Matthew; Liu, Xiao; Zhang, Hao; Zhang, Yong; Li, Jun; Li, Yun; Li, Li; Woollard, Peter; Topp, Simon; Hall, Matthew D.; Nangle, Keith; Wang, Jun; Abecasis, Gonçalo; Cardon, Lon R.; Zöllner, Sebastian; Whittaker, John C.; Chissoe, Stephanie L.; Novembre, John; Mooser, Vincent
2015-01-01
Rare genetic variants contribute to complex disease risk; however, the abundance of rare variants in human populations remains unknown. We explored this spectrum of variation by sequencing 202 genes encoding drug targets in 14,002 individuals. We find rare variants are abundant (one every 17 bases) and geographically localized, such that even with large sample sizes, rare variant catalogs will be largely incomplete. We used the observed patterns of variation to estimate population growth parameters, the proportion of variants in a given frequency class that are putatively deleterious, and mutation rates for each gene. Overall we conclude that, due to rapid population growth and weak purifying selection, human populations harbor an abundance of rare variants, many of which are deleterious and have relevance to understanding disease risk. PMID:22604722
24 CFR 35.1330 - Interim controls.
Code of Federal Regulations, 2013 CFR
2013-04-01
... on the Internet at http://www.hud.gov/offices/lead, or by mail or fax from the HUD Office of Healthy Homes and Lead Hazard Control at (202) 755-1785, extension 104 (this is not a toll-free number). Persons... the toll-free Federal Information Relay Service at (800) 877-8339. (iv) “The Remodeler's and Renovator...
24 CFR 35.1330 - Interim controls.
Code of Federal Regulations, 2014 CFR
2014-04-01
... on the Internet at http://www.hud.gov/offices/lead, or by mail or fax from the HUD Office of Healthy Homes and Lead Hazard Control at (202) 755-1785, extension 104 (this is not a toll-free number). Persons... the toll-free Federal Information Relay Service at (800) 877-8339. (iv) “The Remodeler's and Renovator...
78 FR 27417 - Federal Property Suitable as Facilities To Assist the Homeless
Federal Register 2010, 2011, 2012, 2013, 2014
2013-05-10
..., Washington, DC 20593-0001; (202) 475- 5609; NASA: Mr. Frank T. Bellinger, Facilities Engineering Division...: Unutilized Comments: Off-site removal; 1,836 sf.; storage; 60 months vacant; lead-based paint; very poor....; storage; 60 months vacant; very poor conditions; lead-based paint; repairs a must; rodents w/Hanta virus...
Lead shot incidence on a New Mexico public hunting area
DOE Office of Scientific and Technical Information (OSTI.GOV)
Schranck, B.W.; Dollahon, G.R.
The incidence of lead shot was investigated on a 20.2-ha (50-acre) seasonal marsh used for waterfowl hunting at the Bitter Lake National Wildlife Refuge, Roswell, New Mexico. Of the 162 soil samples taken randomly, 59% contained 1 to 5 lead shot. A minimum lead shot incidence of 98,985 shot per ha (40,075 per acre) was calculated. More shot was found in firm than in mucky soils. Management recommendations to limit waterfowl exposure to lead ingestion are offered.
76 FR 38604 - Inviting Applications for Rural Business Opportunity Grants
Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-01
..., 1835 Black Lake Boulevard SW., Suite B, Olympia, WA 98512-5715, (360) 704-7740/TDD (360) 704-7760. West... (braille, large print, audiotape, etc.) should contact USDA's TARGET Center at (202) 720-2600 (voice and...
78 FR 34975 - Notice of Contract Proposals (NOCP) for the Advanced Biofuels Payment Program
Federal Register 2010, 2011, 2012, 2013, 2014
2013-06-11
....usda.gov . Virgin Islands (see Florida) Washington Mary Traxler, USDA Rural Development, 1835 Black..., large print, audiotape, etc.) should contact USDA's TARGET Center at (202) 720-2600 (voice and TDD). To...
Paul, S P; Caplan, E M; Morgan, H A; Turner, P C
2018-04-01
The National Institute for Health and Care Excellence published guidelines for managing early-onset neonatal infections in 2012. It recommended provision for reporting blood cultures (BCs) with growth detected or not detected at 36 h. To determine if this was followed, a telephone survey was conducted amongst lead biomedical scientists based at microbiology laboratories (N = 209) in the UK. Overall, 202/209 responded and 139/202 had on-site facilities for BCs. BC results with growth detected or not detected at 36 h were available out-of-hours in 36/139 (26.6%) and 66/139 (47.5%) neonatal units, respectively. Early discontinuation of antibiotics should lead to improved antibiotic stewardship. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.
40 CFR 6.202 - Interagency cooperation.
Code of Federal Regulations, 2011 CFR
2011-07-01
...-federal agencies to be joint lead or cooperating agencies as a means of encouraging early coordination and... jurisdiction by law or special expertise. (b) For an EPA action related to an action of any other federal...
40 CFR 6.202 - Interagency cooperation.
Code of Federal Regulations, 2014 CFR
2014-07-01
...-federal agencies to be joint lead or cooperating agencies as a means of encouraging early coordination and... jurisdiction by law or special expertise. (b) For an EPA action related to an action of any other federal...
40 CFR 6.202 - Interagency cooperation.
Code of Federal Regulations, 2013 CFR
2013-07-01
...-federal agencies to be joint lead or cooperating agencies as a means of encouraging early coordination and... jurisdiction by law or special expertise. (b) For an EPA action related to an action of any other federal...
40 CFR 6.202 - Interagency cooperation.
Code of Federal Regulations, 2012 CFR
2012-07-01
...-federal agencies to be joint lead or cooperating agencies as a means of encouraging early coordination and... jurisdiction by law or special expertise. (b) For an EPA action related to an action of any other federal...
40 CFR 6.202 - Interagency cooperation.
Code of Federal Regulations, 2010 CFR
2010-07-01
...-federal agencies to be joint lead or cooperating agencies as a means of encouraging early coordination and... jurisdiction by law or special expertise. (b) For an EPA action related to an action of any other federal...
Directional Characteristics of Inner Shelf Internal Tides
2007-06-01
Figure 18. YD 202-206 Current vector plot of significant events. Significant events include internal tidal bores, solibores, and solitons . The upper...Events (Bores, Solibores, and Solitons ): Upper column leading-edge cross-shore current velocity and cross-shore wind regression. The small ellipse...Significant Events (Bores, Solibores, and Solitons ): Upper column leading-edge along-shore current velocity and along-shore wind regression. The small
Federal Register 2010, 2011, 2012, 2013, 2014
2010-11-23
... loss of the windshield during flight. Also, water could leak into the cockpit and cause either a... structural degradation possibly leading to the loss of the windshield during flight. Also, water could leak... possibly leading to the loss of the windshield during flight. Also, water could leak into the cockpit and...
Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-02
... USDA Rural Development State Office, 1835 Black Lake Boulevard SW., Suite B, Olympia, WA 98512-5715... (Braille, large print, audiotape, etc.) should contact USDA's TARGET Center at (202) 720-2600 (voice and...
75 FR 48696 - Submission for OMB Review; Comment Request
Federal Register 2010, 2011, 2012, 2013, 2014
2010-08-11
... Management and Budget, Paperwork Reduction Project. Fax: 202-395-7285. Email: [email protected] OMB Review; Comment Request Title: ORR Requirements for Refugee Cash Assistance; and Refugee Medical... cash and medical assistance, child welfare, social services, and targeted assistance programs. State-by...
17 CFR 202.6 - Adoption, revision, and rescission of rules and regulations of general application.
Code of Federal Regulations, 2011 CFR
2011-04-01
... accounting rules, every feasible effort is made in advance of adoption to receive the views of persons to be... exchanges, professional societies and leading authorities on the subject concerned and other persons...
17 CFR 202.6 - Adoption, revision, and rescission of rules and regulations of general application.
Code of Federal Regulations, 2013 CFR
2013-04-01
... accounting rules, every feasible effort is made in advance of adoption to receive the views of persons to be... exchanges, professional societies and leading authorities on the subject concerned and other persons...
17 CFR 202.6 - Adoption, revision, and rescission of rules and regulations of general application.
Code of Federal Regulations, 2014 CFR
2014-04-01
... accounting rules, every feasible effort is made in advance of adoption to receive the views of persons to be... exchanges, professional societies and leading authorities on the subject concerned and other persons...
17 CFR 202.6 - Adoption, revision, and rescission of rules and regulations of general application.
Code of Federal Regulations, 2012 CFR
2012-04-01
... accounting rules, every feasible effort is made in advance of adoption to receive the views of persons to be... exchanges, professional societies and leading authorities on the subject concerned and other persons...
Direct and Indirect Phototransformation of Graphene Oxide in Sunlight
Direct and indirect (with added H202 that serves as OH precursor) photoreactions of grapheme oxide (GO) were examined under sunlight exposure. The results indicate that GO photoreacts under both conditions, leading to significant alterations in GO's physicochemical properties. In...
Bartwal, Arti; Pande, Anjali; Sharma, Priyadarshini; Arora, Sandeep
2016-07-01
Drought is a major form of abiotic stress leading to lower crop productivity. Experiment was carried out for selecting the most tolerant genotype among six different genotypes of finger millet under drought stress. Seeds of six finger millet genotypes were sown in pots and grown for 35 days. After this period, drought was induced by withholding watering for stressed plants while control plants were watered regularly for comparison. Among all six different varieties of finger millet screened (PR202, PES400, PRM6107, VL283, VL328 and VL149) under varying intensities of drought stress,PRM6107 and PR202 showed highest stress tolerance by limiting excessive accumulation of reactive oxygen species (ROS) through activation of ROS scavenging antioxidative enzymes. A 200% increase in ascorbate content was recorded in PRM6107 and PR202, while in other varieties limited increase in ascorbate content was observed. Maximum decrease in chlorophyll content was observed in VL328 (83%) while least drop was observed in VL149 (65%). Relative water content indicated that PR202 was able to retain maximum water content under stress, as it recorded least drop in relative water content (55%), contributing to its better survival under stress. In conclusion finger millet genotypes PRM6107 and PR202 possessed maximum drought tolerance potential and thus may be used for allele mining of drought tolerant genes, which can further be employed for the development of more drought stress tolerant staple crops using biotechnological approach.
75 FR 80117 - Methods for Measurement of Filterable PM10
Federal Register 2010, 2011, 2012, 2013, 2014
2010-12-21
...This action promulgates amendments to Methods 201A and 202. The final amendments to Method 201A add a particle-sizing device to allow for sampling of particulate matter with mean aerodynamic diameters less than or equal to 2.5 micrometers (PM2.5 or fine particulate matter). The final amendments to Method 202 revise the sample collection and recovery procedures of the method to reduce the formation of reaction artifacts that could lead to inaccurate measurements of condensable particulate matter. Additionally, the final amendments to Method 202 eliminate most of the hardware and analytical options in the existing method, thereby increasing the precision of the method and improving the consistency in the measurements obtained between source tests performed under different regulatory authorities. This action also announces that EPA is taking no action to affect the already established January 1, 2011 sunset date for the New Source Review (NSR) transition period, during which EPA is not requiring that State NSR programs address condensable particulate matter emissions.
Geduhn, Anke; Jacob, Jens; Schenke, Detlef; Keller, Barbara; Kleinschmidt, Sven; Esther, Alexandra
2015-01-01
Anticoagulant rodenticides (ARs) are commonly used to control rodent infestations for biocidal and plant protection purposes. This can lead to AR exposure of non-target small mammals and their predators, which is known from several regions of the world. However, drivers of exposure variation are usually not known. To identify environmental drivers of AR exposure in non-targets we analyzed 331 liver samples of red foxes (Vulpes vulpes) for residues of eight ARs and used local parameters (percentage of urban area and livestock density) to test for associations to residue occurrence. 59.8% of samples collected across Germany contained at least one rodenticide, in 20.2% of cases at levels at which biological effects are suspected. Second generation anticoagulants (mainly brodifacoum and bromadiolone) occurred more often than first generation anticoagulants. Local livestock density and the percentage of urban area were good indicators for AR residue occurrence. There was a positive association between pooled ARs and brodifacoum occurrence with livestock density as well as of pooled ARs, brodifacoum and difenacoum occurrence with the percentage of urban area on administrative district level. Pig holding drove associations of livestock density to AR residue occurrence in foxes. Therefore, risk mitigation strategies should focus on areas of high pig density and on highly urbanized areas to minimize non-target risk. PMID:26418154
Decay of 201-203Ra and 200-202Fr
NASA Astrophysics Data System (ADS)
Kalaninová, Z.; Antalic, S.; Andreyev, A. N.; Heßberger, F. P.; Ackermann, D.; Andel, B.; Bianco, L.; Hofmann, S.; Huyse, M.; Kindler, B.; Lommel, B.; Mann, R.; Page, R. D.; Sapple, P. J.; Thomson, J.; Van Duppen, P.; Venhart, M.
2014-05-01
Decay properties of the neutron-deficient nuclides 201-203Ra and 200-202Fr were investigated using α- and γ-decay spectroscopy. The nuclei were produced in fusion-evaporation reactions of 56Fe projectiles with enriched 147Sm and 149Sm targets at the velocity filter SHIP at GSI in Darmstadt (Germany). The α decay from the (3/2-) state in 201Ra was identified with an energy Eα=7842(12) keV and half-life T1/2=8-4+40 ms. Ambiguous decay properties for 202Ra from previous measurements were clarified by remeasuring with significantly improved precision, resulting in values of Eα=7722(7) keV and T1/2=3.8-0.8+1.3 ms. New short-lived isomeric states were identified in 200Fr and 201Fr with half-lives of 0.6-0.2+0.5 μs and 0.7-0.2+0.5 μs, respectively. A tentative spin and parity of 13/2+ were assigned to the latter. One event attributed to β-delayed fission of 200Fr was observed.
Federal Register 2010, 2011, 2012, 2013, 2014
2012-10-04
... approved information collection, the List Sampling Frame Surveys. Revision to burden hours will be needed due to changes in the size of the target population, sampling design, and/or questionnaire length... Agriculture, (202) 720-4333. SUPPLEMENTARY INFORMATION: Title: List Sampling Frame Surveys. OMB Control Number...
76 FR 32943 - Announcement of Rural Cooperative Development Grant Application Deadlines
Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-07
... application. It is recommended that the application be in black and white, not color. Those evaluating the application will only receive black and white images. The Agency will then screen all applications for..., large print, audiotape, etc.) should contact USDA's TARGET Center at (202) 720-2600 (voice and TDD). To...
24 CFR 960.206 - Waiting list: Local preferences in admission to public housing program.
Code of Federal Regulations, 2010 CFR
2010-04-01
... subject to HUD requirements concerning income-targeting (§ 960.202(b)), deconcentration and income-mixing... families or for mixed population developments (§ 960.407). (4) The PHA must inform all applicants about... otherwise denying admission to the program based on the race, color, ethnic origin, gender, religion...
24 CFR 960.206 - Waiting list: Local preferences in admission to public housing program.
Code of Federal Regulations, 2011 CFR
2011-04-01
... subject to HUD requirements concerning income-targeting (§ 960.202(b)), deconcentration and income-mixing... families or for mixed population developments (§ 960.407). (4) The PHA must inform all applicants about... otherwise denying admission to the program based on the race, color, ethnic origin, gender, religion...
75 FR 51191 - Great Lakes Pilotage Rates-2011 Annual Review and Adjustment
Federal Register 2010, 2011, 2012, 2013, 2014
2010-08-19
...-AB48 Great Lakes Pilotage Rates--2011 Annual Review and Adjustment AGENCY: Coast Guard, DHS. ACTION... the Great Lakes to generate sufficient revenue to cover allowable expenses, target pilot compensation..., Chief, Great Lakes Pilotage Division, Commandant (CG-5522), U.S. Coast Guard, at 202-372-1535, by fax...
77 FR 47073 - Agency Forms Undergoing Paperwork Reduction Act Review
Federal Register 2010, 2011, 2012, 2013, 2014
2012-08-07
... about the child's behaviors. If the child is between 12 and 17 years of age, he or she will be asked to... estimate the effect of all CTG interventions on health behaviors and health outcomes in adults and children... (202) 395-5806. Proposed Project Targeted Surveillance and Biometric Studies for Enhanced Evaluation of...
Liu, Jie; Silapong, Sasikorn; Jeanwattanalert, Pimmada; Lertsehtakarn, Paphavee; Bodhidatta, Ladaporn; Swierczewski, Brett; Mason, Carl; McVeigh, Annette L; Savarino, Stephen J; Nshama, Rosemary; Mduma, Esto; Maro, Athanasia; Zhang, Jixian; Gratz, Jean; Houpt, Eric R
2017-01-01
Enterotoxigenic Escherichia coli (ETEC) is a leading cause of childhood diarrhea in low income countries and in travelers to those areas. Inactivated enterotoxins and colonization factors (CFs) are leading vaccine candidates, therefore it is important to determine the prevailing CF types in different geographic locations and populations. Here we developed real time PCR (qPCR) assays for 14 colonization factors, including the common vaccine targets. These assays, along with three enterotoxin targets (STh, STp, and LT) were formulated into three 5-plex qPCR panels, and validated on 120 ETEC isolates and 74 E. coli colony pools. The overall sensitivity and specificity was 99% (199/202) and 99% (2497/2514), respectively, compared to the CF results obtained with conventional PCR. Amplicon sequencing of discrepant samples revealed that the qPCR was 100% accurate. qPCR panels were also performed on nucleic acid extracted from stool and compared to the results of the ETEC isolates or E. coli colony pools cultured from them. 95% (105/110) of the CF detections in the cultures were confirmed in the stool. Additionally, direct testing of stool yielded 30 more CF detections. Among 74 randomly selected E. coli colony pools with paired stool, at least one CF was detected in 63% (32/51) of the colony pools while at least one CF was detected in 78% (47/60) of the stool samples (P = NS). We conclude that these ETEC CF assays can be used on both cultures and stool samples to facilitate better understanding of CF distribution for ETEC epidemiology and vaccine development.
The Nature of Ritalin: A Response to Cooter.
ERIC Educational Resources Information Center
Mick, Lori Bell
1991-01-01
In response to Robert Cooter, Jr. (EC 202 670), who questioned the widespread use of Ritalin with children having attention deficit hyperactivity disorders, this commentary considers four specific points: how Ritalin works, Ritalin's side effects and relationship to Tourette syndrome, the assumption that Ritalin leads to drug abuse, and the…
Towards the intelligent design of a vaccine against Edwardsiella ictaluri
USDA-ARS?s Scientific Manuscript database
Edwardsiella ictaluri is the leading cause of disease loss in the catfish industry in the United States, accounting for an estimated 20.2 % loss in 2009. Previous work to establish live-attenuated vaccines for E. ictaluri demonstrated a relatively weak channel catfish immune response, with better im...
Federal Register 2010, 2011, 2012, 2013, 2014
2010-09-27
..., Science and Education Resources Development; Voice: 202-720-2067; E-mail: [email protected] rural communities. Authority Section 1405 of the National Agricultural Research, Extension, and Teaching... (USDA) as the lead Federal agency for agriculture research, extension and teaching in the food and...
Federal Register 2010, 2011, 2012, 2013, 2014
2013-02-06
... Homes Supplemental Funding AGENCY: Office of the Chief Information Officer, HUD. ACTION: Notice. SUMMARY... Pollard, Department Reports Management Officer, Office of the Chief Information Officer. [FR Doc. 2013...: 202-395-5806. FOR FURTHER INFORMATION CONTACT: Colette Pollard., Reports Management Officer, QDAM...
77 FR 46340 - Airworthiness Directives; The Boeing Company Airplanes
Federal Register 2010, 2011, 2012, 2013, 2014
2012-08-03
... repetitive inspections for cracking of the elevator actuator fittings. Since we issued that AD, the... actuator fitting or incorrectly installed bolts to the actuator fitting, which could lead to the elevator... submitting comments. Fax: 202-493-2251. Mail: U.S. Department of Transportation, Docket Operations, M-30...
Cryogenic Target-Implosion Experiments on OMEGA
DOE Office of Scientific and Technical Information (OSTI.GOV)
Harding, D.R.; Meyerhofer, D.D.; Sangster, T.C.
The University of Rochester’s Laboratory for Laser Energetics has been imploding thick cryogenic targets for six years. Improvements in the Cryogenic Target Handling System and the ability to accurately design laser pulse shapes that properly time shocks and minimize electron preheat, produced high fuel areal densities in deuterium cryogenic targets (202+/-7 mg/cm^2). The areal density was inferred from the energy loss of secondary protons in the fuel (D2) shell. Targets were driven on a low final adiabat (alpha = 2) employing techniques to radially grade the adiabat (the highest adiabat at the ablation surface). The ice layer meets the target-designmore » toughness specification for DT ice of 1-um rms (all modes), while D2 ice layers average 3.0-um-rms roughness. The implosion experiments and the improvements in the quality and understanding of cryogenic targets are presented.« less
Fouladi, Naghmeh; Parker, Maria; Kennedy, Vicky; Binley, Katie; McCloskey, Laura; Loader, Julie; Kelleher, Michelle; Mitrophanous, Kyriacos A; Stout, J Timothy; Ellis, Scott
2018-06-01
Due to both the avascularity of the cornea and the relatively immune-privileged status of the eye, corneal transplantation is one of the most successful clinical transplant procedures. However, in high-risk patients, which account for >20% of the 180,000 transplants carried out worldwide each year, the rejection rate is high due to vascularization of the recipient cornea. The main reason for graft failure is irreversible immunological rejection, and it is therefore unsurprising that neovascularization (NV; both pre and post grafting) is a significant risk factor for subsequent graft failure. NV is thus an attractive target to prevent corneal graft rejection. OXB-202 (previously known as EncorStat ® ) is a donor cornea modified prior to transplant by ex vivo genetic modification with genes encoding secretable forms of the angiostatic human proteins, endostatin and angiostatin. This is achieved using a lentiviral vector derived from the equine infectious anemia virus called pONYK1EiA, which subsequently prevents rejection by suppressing NV. Previously, it has been shown that rabbit donor corneas treated with pONYK1EiA substantially suppress corneal NV, opacity, and subsequent rejection in an aggressive rabbit model of cornea graft rejection. Here, efficacy data are presented in a second rabbit model, which more closely mirrors the clinical setting for high-risk corneal transplant patients, and safety data from a 3-month good laboratory practice toxicology and biodistribution study of pONYK1EiA-modified rabbit corneas in a rabbit corneal transplant model. It is shown that pONYK1EiA-modified rabbit corneas (OXB-202) significantly reduce corneal NV and the rate of corneal rejection in a dose-dependent fashion, and are tolerated with no adverse toxicological findings or significant biodistribution up to 13 weeks post surgery in these rabbit studies. In conclusion, angiogenesis is a valid target to prevent corneal graft rejection in a high-risk setting, and transplanted genetically modified corneas are safe and well-tolerated in an animal model. These data support the evaluation of OXB-202 in a first-in-human trial.
3 CFR 13508 - Executive Order 13508 of May 12, 2009. Chesapeake Bay Protection and Restoration
Code of Federal Regulations, 2010 CFR
2010-01-01
... of the Nation's largest estuarine ecosystem and the natural sustainability of its watershed, it is... be officers of the United States. Sec. 202. Reports on Key Challenges to Protecting and Restoring the... lead agencies shall prepare and submit draft reports to the Committee making recommendations for...
Comprehensive Technology Utilization Leading to Excellence in Medium Sized Schools.
ERIC Educational Resources Information Center
Diercks, Eileen; And Others
Although limited finances and a student body of 3,200 have made it necessary to be selective in acquiring educational technology, the Plainfield (Illinois) Community Consolidated School District No. 202 has been very active in the regional partnership for excellence. Curricular programs at the Plainfield High School include use of…
D’Ambrosio, Steven M.; Han, Chunhua; Pan, Li; Kinghorn, A. Douglas; Ding, Haiming
2011-01-01
Avocado (Persea americana) fruits are consumed as part of the human diet and extracts have shown growth inhibitory effects in various types of human cancer cells, although the effectiveness of individual components and their underlying mechanism are poorly understood. Using activity-guided fractionation of the flesh of avocado fruits, a chloroform-soluble extract (D003), was identified that exhibited high efficacy towards premalignant and malignant human oral cancer cell lines. From this extract, two aliphatic acetogenins of previously known structure were isolated, compounds 1 [(2S,4S)-2,4-dihydroxyheptadec-16-enyl acetate] and 2 [(2S,4S)-2,4-dihydroxyheptadec-16-ynyl acetate]. In this study, we show for the first time that the growth inhibitory efficacy of this chloroform extract is due to blocking the phosphorylation of EGFR (Tyr1173), c-RAF (Ser338), and ERK1/2 (Thr202/Tyr204) in the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway. Compound 1 and 2 both inhibited phosphorylation of c-RAF (Ser338) and ERK1/2 (Thr202/Tyr204). Compound 2, but not compound 1, prevented EGF-induced activation of EGFR (Tyr1173). When compounds 1 and 2 were combined they synergistically inhibited c-RAF (Ser338) and ERK1/2 (Thr202/Tyr204) phosphorylation, and human oral cancer cell proliferation. The present data suggest that the potential anticancer activity of avocado fruits is due to a combination of specific aliphatic acetogenins that target two key components of the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway. PMID:21596018
D'Ambrosio, Steven M; Han, Chunhua; Pan, Li; Kinghorn, A Douglas; Ding, Haiming
2011-06-10
Avocado (Persea americana) fruits are consumed as part of the human diet and extracts have shown growth inhibitory effects in various types of human cancer cells, although the effectiveness of individual components and their underlying mechanism are poorly understood. Using activity-guided fractionation of the flesh of avocado fruits, a chloroform-soluble extract (D003) was identified that exhibited high efficacy towards premalignant and malignant human oral cancer cell lines. From this extract, two aliphatic acetogenins of previously known structure were isolated, compounds 1 [(2S,4S)-2,4-dihydroxyheptadec-16-enyl acetate] and 2 [(2S,4S)-2,4-dihydroxyheptadec-16-ynyl acetate]. In this study, we show for the first time that the growth inhibitory efficacy of this chloroform extract is due to blocking the phosphorylation of EGFR (Tyr1173), c-RAF (Ser338), and ERK1/2 (Thr202/Tyr204) in the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway. Compounds 1 and 2 both inhibited phosphorylation of c-RAF (Ser338) and ERK1/2 (Thr202/Tyr204). Compound 2, but not compound 1, prevented EGF-induced activation of the EGFR (Tyr1173). When compounds 1 and 2 were combined they synergistically inhibited c-RAF (Ser338) and ERK1/2 (Thr202/Tyr204) phosphorylation, and human oral cancer cell proliferation. The present data suggest that the potential anticancer activity of avocado fruits is due to a combination of specific aliphatic acetogenins that target two key components of the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway. Copyright © 2011 Elsevier Inc. All rights reserved.
ERIC Educational Resources Information Center
Mavrikaki, Evangelia; Athanasiou, Kyriacos
2011-01-01
The self-efficacy beliefs of in-service elementary school teachers in Greece were examined in an attempt to evaluate their biology teaching skills. For this purpose, we constructed a valid and reliable instrument consisting of a Likert-type questionnaire that was distributed to the target population and to which 202 teachers responded. Results…
Cross sections of proton-induced nuclear reactions on bismuth and lead up to 100 MeV
NASA Astrophysics Data System (ADS)
Mokhtari Oranj, L.; Jung, N. S.; Bakhtiari, M.; Lee, A.; Lee, H. S.
2017-04-01
Production cross sections of 209Bi(p , x n )207,206,205,204,203Po, 209Bi(p , pxn) 207,206,205,204,203,202Bi, and natPb(p , x n ) 206,205,204,203,202,201Bi reactions were measured to fill the gap in the excitation functions up to 100 MeV as well as to figure out the effects of different nuclear properties on proton-induced reactions including heavy nuclei. The targets were arranged in two different stacks consisting of Bi, Pb, Al, Au foils and Pb plates. The proton beam intensity was determined by the activation analysis method using 27Al(p ,3 p n )24Na, 197Au(p ,p n )196Au, and 197Au(p , p 3 n )194Au monitor reactions in parallel as well as the Gafchromic film dosimetry method. The activities of produced radionuclei in the foils were measured by the HPGe spectroscopy system. Over 40 new cross sections were measured in the investigated energy range. A satisfactory agreement was observed between the present experimental data and the previously published data. Excitation functions of mentioned reactions were calculated by using the theoretical model based on the latest version of the TALYS code and compared to the new data as well as with other data in the literature. Additionally, the effects of various combinations of the nuclear input parameters of different level density models, optical model potentials, and γ-ray strength functions were considered. It was concluded that if certain level density models are used, the calculated cross sections could be comparable to the measured data. Furthermore, the effects of optical model potential and γ-ray strength functions were considerably lower than that of nuclear level densities.
Federal Register 2010, 2011, 2012, 2013, 2014
2011-05-02
... structural degradation possibly leading to the loss of the windshield during flight. Also, water could leak... during flight. Also, water could leak into the cockpit and cause either a malfunction or failure of the... the windshield during flight. Also, water could leak into the cockpit and cause either a malfunction...
Federal Register 2010, 2011, 2012, 2013, 2014
2013-05-24
... immediately attempt to regulate new farm and construction equipment and that under any compliance pathway a... from new nonroad engines which are used in construction equipment or vehicles or used in farm equipment... with section 202(a) if: (1) There is inadequate lead time to permit the development of the necessary...
Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-21
... newly deployed monitors can be considered in making appropriate designation decisions. States previously... submitting comments. E-mail: [email protected] . Attention Docket ID No. EPA-HQ-OAR-2009-0443. Fax: 202-566-9744. Attention Docket ID No. EPA-HQ-OAR- 2009-0443. Mail: Air Docket, Attention Docket ID No. EPA...
Federal Register 2010, 2011, 2012, 2013, 2014
2010-08-18
... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... A340-541 and -642 Airplanes AGENCY: Federal Aviation Administration (FAA), Department of Transportation...-going to determine the root cause(s). This condition, if not corrected, could lead to an air leak...
76 FR 21692 - National Emission Standards for Hazardous Air Pollutants: Primary Lead Smelting
Federal Register 2010, 2011, 2012, 2013, 2014
2011-04-18
[email protected] . Attention Docket ID Number EPA-HQ-OAR-2004-0305. Fax: (202) 566-9744. Attention Docket... (6102T), EPA West (Air Docket), Attention Docket ID Number EPA- HQ-OAR-2004-0305, U.S. Environmental... Agency, EPA West (Air Docket), Room 3334, 1301 Constitution Avenue, NW., Washington, DC 20004, Attention...
77 FR 12933 - Federal Acquisition Regulation: Trade Agreements Thresholds
Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-02
...: --Canada 25,000 77,494 10,074,262 --Mexico 77,494 77,494 10,074,262 Oman FTA 202,000 202,000 10,074,262... 77,494 77,494 10,074,262 Oman FTA 202,000 202,000 10,074,262 Peru FTA 202,000 202,000 7,777,000...
Loss of the HVEM tumor suppressor in lymphoma and restoration by modified CAR-T cells
Sanghvi, Viraj; Amin, Rada; Oricchio, Elisa; Jiang, Man; Mottok, Anja; Denis-Lagache, Nicolas; Ciriello, Giovanni; Tam, Wayne; Teruya-Feldstein, Julie; de Stanchina, Elisa; Chan, Wing C.; Malek, Sami N.; Ennishi, Daisuke; Brentjens, Renier J.; Gascoyne, Randy D.; Cogne, Michel; Tarte, Karin; Wendel, Hans-Guido
2016-01-01
The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in germinal center lymphomas. We report that loss of HVEM leads to cell autonomous activation of B cell proliferation and drives the development of GC lymphomas in vivo. HVEM deficient lymphoma B cells also induce a tumor supportive microenvironment marked by exacerbated lymphoid stroma activation and increased recruitment of T follicular helper (TFH) cells. These changes result from the disruption of inhibitory cell-cell interactions between the HVEM and BTLA (B and T Lymphocyte Attenuator) receptors. Accordingly, administration of the HVEM ectodomain protein (solHVEM(P37-V202)) binds BTLA and restores tumor suppression. To deliver solHVEM to lymphomas in vivo we engineered CD19-targeted chimeric antigen receptor (CAR) T cells that produce solHVEM locally and continuously. These modified CAR-T cells show enhanced therapeutic activity against xenografted lymphomas. Hence, the HVEM-BTLA axis opposes lymphoma development and our study illustrates the use of CAR-T cells as ‘micro-pharmacies’ able to deliver an anti-cancer protein. PMID:27693350
Sunrayce 97 Continues Day 4 - Fulton to Lee's Summit
(202) 586-0713 Lee's Summit, MO -- Massachusetts Institute of Technology (MIT) took Day IV and maintained the overall lead as sunrayce 97 completed its fourth day. The elapsed time for the day for the attaining good sun early enough in the day to replenish the batteries, as such a fast pace will deplete them
Federal Register 2010, 2011, 2012, 2013, 2014
2010-11-10
... Buildings. DATES: There will be a public meeting held on December 6, 2010 from 9 a.m. to 5 p.m. (Eastern... 20005; telephone (202) 862-1600. FOR FURTHER INFORMATION CONTACT: Any member of the public wishing to obtain information concerning the public meeting may contact Mr. Aaron Yeow, Designated Federal Officer...
Assessing the Effectiveness of Deradicalization Programs for Islamist Extremists
2009-12-01
attacks had a significant impact on Indonesia’s economy and greatly damaged the tourism industry . Indonesia has been slow to recognize the problem...Yemen has experienced a significant number of terrorist attacks on its soil targeting both western interests and Yemen’s economic and tourism ...conducting attacks within Indonesia against Westerners. In 2002, JI members executed bombings in the popular tourist areas in Bali killing 202 people. JI
Gasparotto, Juciano; Girardi, Carolina S; Somensi, Nauana; Ribeiro, Camila T; Moreira, José C F; Michels, Monique; Sonai, Beatriz; Rocha, Mariane; Steckert, Amanda V; Barichello, Tatiana; Quevedo, João; Dal-Pizzol, Felipe; Gelain, Daniel P
2018-01-05
Patients recovering from sepsis have higher rates of CNS morbidities associated with long-lasting impairment of cognitive functions, including neurodegenerative diseases. However, the molecular etiology of these sepsis-induced impairments is unclear. Here, we investigated the role of the receptor for advanced glycation end products (RAGE) in neuroinflammation, neurodegeneration-associated changes, and cognitive dysfunction arising after sepsis recovery. Adult Wistar rats underwent cecal ligation and perforation (CLP), and serum and brain (hippocampus and prefrontal cortex) samples were obtained at days 1, 15, and 30 after the CLP. We examined these samples for systemic and brain inflammation; amyloid-β peptide (Aβ) and Ser-202-phosphorylated Tau (p-Tau Ser-202 ) levels; and RAGE, RAGE ligands, and RAGE intracellular signaling. Serum markers associated with the acute proinflammatory phase of sepsis (TNFα, IL-1β, and IL-6) rapidly increased and then progressively decreased during the 30-day period post-CLP, concomitant with a progressive increase in RAGE ligands (S100B, N ϵ-[carboxymethyl]lysine, HSP70, and HMGB1). In the brain, levels of RAGE and Toll-like receptor 4, glial fibrillary acidic protein and neuronal nitric-oxide synthase, and Aβ and p-Tau Ser-202 also increased during that time. Of note, intracerebral injection of RAGE antibody into the hippocampus at days 15, 17, and 19 post-CLP reduced Aβ and p-Tau Ser-202 accumulation, Akt/mechanistic target of rapamycin signaling, levels of ionized calcium-binding adapter molecule 1 and glial fibrillary acidic protein, and behavioral deficits associated with cognitive decline. These results indicate that brain RAGE is an essential factor in the pathogenesis of neurological disorders following acute systemic inflammation. © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 19 Customs Duties 3 2010-04-01 2010-04-01 false Applications. 202.2 Section 202.2 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.2 Applications. (a) Who may file. Applications for an investigation to which this part 202...
Code of Federal Regulations, 2012 CFR
2012-04-01
... 19 Customs Duties 3 2012-04-01 2012-04-01 false Applications. 202.2 Section 202.2 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.2 Applications. (a) Who may file. Applications for an investigation to which this part 202...
Code of Federal Regulations, 2011 CFR
2011-04-01
... 19 Customs Duties 3 2011-04-01 2011-04-01 false Applications. 202.2 Section 202.2 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.2 Applications. (a) Who may file. Applications for an investigation to which this part 202...
Code of Federal Regulations, 2013 CFR
2013-04-01
... 19 Customs Duties 3 2013-04-01 2013-04-01 false Applications. 202.2 Section 202.2 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.2 Applications. (a) Who may file. Applications for an investigation to which this part 202...
Code of Federal Regulations, 2014 CFR
2014-04-01
... 19 Customs Duties 3 2014-04-01 2014-04-01 false Applications. 202.2 Section 202.2 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.2 Applications. (a) Who may file. Applications for an investigation to which this part 202...
31 CFR 202.6 - Collateral security.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false Collateral security. 202.6 Section 202... GOVERNMENT 1 § 202.6 Collateral security. (a) Requirement. Prior to receiving deposits of public money, a depositary authorized to perform services under § 202.3(b) must pledge collateral security in the amount...
31 CFR 202.6 - Collateral security.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false Collateral security. 202.6 Section 202... GOVERNMENT 1 § 202.6 Collateral security. (a) Requirement. Prior to receiving deposits of public money, a depositary authorized to perform services under § 202.3(b) must pledge collateral security in the amount...
31 CFR 202.6 - Collateral security.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Collateral security. 202.6 Section 202... GOVERNMENT 1 § 202.6 Collateral security. (a) Requirement. Prior to receiving deposits of public money, a depositary authorized to perform services under § 202.3(b) must pledge collateral security in the amount...
Code of Federal Regulations, 2011 CFR
2011-01-01
... 12 Banks and Banking 2 2011-01-01 2011-01-01 false General rules. 202.4 Section 202.4 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM EQUAL CREDIT OPPORTUNITY... by §§ 202.5 and 202.13, in a form the applicant may retain. (2) Disclosures in electronic form. The...
Code of Federal Regulations, 2010 CFR
2010-10-01
... COMPETITION REQUIREMENTS Full and Open Competition After Exclusion of Sources 1806.202 Establishing or maintaining alternative sources. (NASA supplements paragraphs (a) and (b)) (a) The authority of FAR 6.202 is... alternative sources. (NASA supplements paragraphs (a) and (b)) 1806.202 Section 1806.202 Federal Acquisition...
The human RHOX gene cluster: target genes and functional analysis of gene variants in infertile men.
Borgmann, Jennifer; Tüttelmann, Frank; Dworniczak, Bernd; Röpke, Albrecht; Song, Hye-Won; Kliesch, Sabine; Wilkinson, Miles F; Laurentino, Sandra; Gromoll, Jörg
2016-11-15
The X-linked reproductive homeobox (RHOX) gene cluster encodes transcription factors preferentially expressed in reproductive tissues. This gene cluster has important roles in male fertility based on phenotypic defects of Rhox-mutant mice and the finding that aberrant RHOX promoter methylation is strongly associated with abnormal human sperm parameters. However, little is known about the molecular mechanism of RHOX function in humans. Using gene expression profiling, we identified genes regulated by members of the human RHOX gene cluster. Some genes were uniquely regulated by RHOXF1 or RHOXF2/2B, while others were regulated by both of these transcription factors. Several of these regulated genes encode proteins involved in processes relevant to spermatogenesis; e.g. stress protection and cell survival. One of the target genes of RHOXF2/2B is RHOXF1, suggesting cross-regulation to enhance transcriptional responses. The potential role of RHOX in human infertility was addressed by sequencing all RHOX exons in a group of 250 patients with severe oligozoospermia. This revealed two mutations in RHOXF1 (c.515G > A and c.522C > T) and four in RHOXF2/2B (-73C > G, c.202G > A, c.411C > T and c.679G > A), of which only one (c.202G > A) was found in a control group of men with normal sperm concentration. Functional analysis demonstrated that c.202G > A and c.679G > A significantly impaired the ability of RHOXF2/2B to regulate downstream genes. Molecular modelling suggested that these mutations alter RHOXF2/F2B protein conformation. By combining clinical data with in vitro functional analysis, we demonstrate how the X-linked RHOX gene cluster may function in normal human spermatogenesis and we provide evidence that it is impaired in human male fertility.
2014-10-01
carcinoma with different signaling pathways characteristic of each histo- logical pattern. eIF4E-driven protein translation pathway is el - evated in...and 4EBP1 ( Epitomics ); Histone H3, AKT, and p4EBP1 (Thr37/46); pErk1/ 2 (T202/Y204), pSTAT3 (Y705), Sox2, MTA1, Src, and pSrc (Y416) (Cell Signaling
Federal Register 2010, 2011, 2012, 2013, 2014
2013-02-07
...) 663-4070 (voice) or (202) 663-4074 (TTD). (These are not toll-free telephone numbers.) Instead of... staff at (202) 663-4630 (voice) or (202) 663-4641 (TTY). (These are not toll-free numbers.) FOR FURTHER... 4SW30F, Washington, DC 20507; (202) 663-4958 (voice) or (202) 663-7063 (TTY). SUPPLEMENTARY INFORMATION...
ACHP | Advisory Council on Historic Preservation Staff Directory
general counsel kfanizzo@achp.gov 202-517-0193 Office of Administration Ismail D. Ahmed, senior accountant wdancingfeather@achp.gov 202-517-0195 Ira Matt, Senior Policy Analyst imatt@achp.gov 202-517-1481 Office of specialist lrichmond@achp.gov 202-517-1484 Shayla Shrieves, senior writer-editor sshrieves@achp.gov 202-517
37 CFR Appendix A to Part 202 - Technical Guidelines Regarding Sound Physical Condition
Code of Federal Regulations, 2010 CFR
2010-07-01
... Regarding Sound Physical Condition A Appendix A to Part 202 Patents, Trademarks, and Copyrights COPYRIGHT... COPYRIGHT Pt. 202, App. A Appendix A to Part 202—Technical Guidelines Regarding Sound Physical Condition To be considered a copy “of sound physical condition” within the meaning of 37 CFR 202.22(d)(5), a copy...
37 CFR Appendix A to Part 202 - Technical Guidelines Regarding Sound Physical Condition
Code of Federal Regulations, 2011 CFR
2011-07-01
... Regarding Sound Physical Condition A Appendix A to Part 202 Patents, Trademarks, and Copyrights COPYRIGHT... COPYRIGHT Pt. 202, App. A Appendix A to Part 202—Technical Guidelines Regarding Sound Physical Condition To be considered a copy “of sound physical condition” within the meaning of 37 CFR 202.22(d)(5), a copy...
Orexin OX2 Receptor Antagonists as Sleep Aids.
Jacobson, Laura H; Chen, Sui; Mir, Sanjida; Hoyer, Daniel
The discovery of the orexin system represents the single major progress in the sleep field of the last three to four decades. The two orexin peptides and their two receptors play a major role in arousal and sleep/wake cycles. Defects in the orexin system lead to narcolepsy with cataplexy in humans and dogs and can be experimentally reproduced in rodents. At least six orexin receptor antagonists have reached Phase II or Phase III clinical trials in insomnia, five of which are dual orexin receptor antagonists (DORAs) that target both OX 1 and OX 2 receptors (OX 2 Rs). All clinically tested DORAs induce and maintain sleep: suvorexant, recently registered in the USA and Japan for insomnia, represents the first hypnotic principle that acts in a completely different manner from the current standard medications. It is clear, however, that in the clinic, all DORAs promote sleep primarily by increasing rapid eye movement (REM) and are almost devoid of effects on slow-wave (SWS) sleep. At present, there is no consensus on whether the sole promotion of REM sleep has a negative impact in patients suffering from insomnia. However, sleep onset REM (SOREM), which has been documented with DORAs, is clearly an undesirable effect, especially for narcoleptic patients and also in fragile populations (e.g. elderly patients) where REM-associated loss of muscle tone may promote an elevated risk of falls. Debate thus remains as to the ideal orexin agent to achieve a balanced increase in REM and non-rapid eye movement (NREM) sleep. Here, we review the evidence that an OX 2 R antagonist should be at least equivalent, or perhaps superior, to a DORA for the treatment of insomnia. An OX 2 R antagonist may produce more balanced sleep than a DORA. Rodent sleep experiments show that the OX 2 R is the primary target of orexin receptor antagonists in sleep modulation. Furthermore, an OX 2 R antagonist should, in theory, have a lower narcoleptic/cataplexic potential. In the clinic, the situation remains equivocal, since OX 2 R antagonists are in early stages: MK-1064 has completed Phase I, and MIN202 is currently in clinical Phase II/III trials. However, data from insomnia patients have not yet been released. Promotional material suggests that balanced sleep is indeed induced by MIN-202, whereas in volunteers MK-1064 has been reported to act similarly to DORAs.
37 CFR Appendix A to Part 202 - Technical Guidelines Regarding Sound Physical Condition
Code of Federal Regulations, 2014 CFR
2014-07-01
... Regarding Sound Physical Condition A Appendix A to Part 202 Patents, Trademarks, and Copyrights U.S... CLAIMS TO COPYRIGHT Pt. 202, App. A Appendix A to Part 202—Technical Guidelines Regarding Sound Physical Condition To be considered a copy “of sound physical condition” within the meaning of 37 CFR 202.22(d)(5), a...
49 CFR 179.202-179.202-22 - [Reserved
Code of Federal Regulations, 2012 CFR
2012-10-01
... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) §§ 179.202—179.202-22 [Reserved] ...
48 CFR 9903.202 - Disclosure requirements.
Code of Federal Regulations, 2010 CFR
2010-10-01
... ACCOUNTING STANDARDS CONTRACT COVERAGE CAS Program Requirements 9903.202 Disclosure requirements. ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Disclosure requirements. 9903.202 Section 9903.202 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD...
McVea, David A; Himsworth, Chelsea G; Patrick, David M; Lindsay, L Robbin; Kosoy, Michael; Kerr, Thomas
2018-02-01
Rat infestations are common, particularly in impoverished, inner-city neighborhoods. However, there has been little research into the nature and consequences of rat exposure in these neighborhoods, particularly in Canada. In this study, we sought to characterize exposure to rats and rat-associated Leptospira interrogans and Bartonella tribocorum, as well as risk factors associated with exposure, in residents (n = 202) of the Downtown Eastside (DTES) neighborhood of Vancouver, Canada. There was no evidence of exposure to rat-associated L. interrogans but 6/202 (3.0%) of participants were exposed to B. tribocorum, which is known to be circulating among DTES rats. We also found that frequent and close rat exposure was common among DTES residents, and that this exposure was particularly associated with injection drug use and outdoor income-generating activities (e.g., drug dealing). These risk factors may be good targets for interventions geared toward effectively reducing rat exposure.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Policy. 609.202 Section 609.202 Federal Acquisition Regulations System DEPARTMENT OF STATE COMPETITION AND ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Qualifications Requirements 609.202 Policy. The authority prescribed in...
48 CFR 2919.202 - Specific policies.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Specific policies. 2919.202 Section 2919.202 Federal Acquisition Regulations System DEPARTMENT OF LABOR SOCIOECONOMIC PROGRAMS SMALL BUSINESS AND SMALL DISADVANTAGED BUSINESS CONCERNS Policies 2919.202 Specific policies...
Code of Federal Regulations, 2013 CFR
2013-10-01
... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Definition. 39.202 Section 39.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Electronic and Information Technology 39.202 Definition...
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Definition. 39.202 Section 39.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Electronic and Information Technology 39.202 Definition...
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Definition. 39.202 Section 39.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Electronic and Information Technology 39.202 Definition...
Code of Federal Regulations, 2014 CFR
2014-10-01
... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Definition. 39.202 Section 39.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Electronic and Information Technology 39.202 Definition...
Code of Federal Regulations, 2012 CFR
2012-10-01
... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Definition. 39.202 Section 39.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Electronic and Information Technology 39.202 Definition...
48 CFR 1330.202 - Disclosure requirements.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Disclosure requirements. 1330.202 Section 1330.202 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 1330.202 Disclosure...
48 CFR 1430.202 - Disclosure requirements.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Disclosure requirements. 1430.202 Section 1430.202 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 1430.202 Disclosure...
48 CFR 30.202 - Disclosure requirements.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Disclosure requirements. 30.202 Section 30.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 30.202 Disclosure...
48 CFR 430.202 - Disclosure requirements.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Disclosure requirements. 430.202 Section 430.202 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 430.202 Disclosure...
48 CFR 30.202 - Disclosure requirements.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Disclosure requirements. 30.202 Section 30.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 30.202 Disclosure...
48 CFR 1330.202 - Disclosure requirements.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Disclosure requirements. 1330.202 Section 1330.202 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 1330.202 Disclosure...
48 CFR 1430.202 - Disclosure requirements.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Disclosure requirements. 1430.202 Section 1430.202 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 1430.202 Disclosure...
48 CFR 430.202 - Disclosure requirements.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Disclosure requirements. 430.202 Section 430.202 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 430.202 Disclosure...
48 CFR 2406.202 - Establishing or maintaining alternative sources.
Code of Federal Regulations, 2011 CFR
2011-10-01
... maintaining alternative sources. 2406.202 Section 2406.202 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT COMPETITION AND ACQUISITION PLANNING COMPETITION REQUIREMENTS Full and Open Competition After Exclusion of Sources 2406.202 Establishing or maintaining alternative...
Tong, Tong; Wolz, Robin; Coupé, Pierrick; Hajnal, Joseph V; Rueckert, Daniel
2013-08-01
We propose a novel method for the automatic segmentation of brain MRI images by using discriminative dictionary learning and sparse coding techniques. In the proposed method, dictionaries and classifiers are learned simultaneously from a set of brain atlases, which can then be used for the reconstruction and segmentation of an unseen target image. The proposed segmentation strategy is based on image reconstruction, which is in contrast to most existing atlas-based labeling approaches that rely on comparing image similarities between atlases and target images. In addition, we propose a Fixed Discriminative Dictionary Learning for Segmentation (F-DDLS) strategy, which can learn dictionaries offline and perform segmentations online, enabling a significant speed-up in the segmentation stage. The proposed method has been evaluated for the hippocampus segmentation of 80 healthy ICBM subjects and 202 ADNI images. The robustness of the proposed method, especially of our F-DDLS strategy, was validated by training and testing on different subject groups in the ADNI database. The influence of different parameters was studied and the performance of the proposed method was also compared with that of the nonlocal patch-based approach. The proposed method achieved a median Dice coefficient of 0.879 on 202 ADNI images and 0.890 on 80 ICBM subjects, which is competitive compared with state-of-the-art methods. Copyright © 2013 Elsevier Inc. All rights reserved.
48 CFR 906.202 - Establishing or maintaining alternative sources.
Code of Federal Regulations, 2010 CFR
2010-10-01
... maintaining alternative sources. 906.202 Section 906.202 Federal Acquisition Regulations System DEPARTMENT OF ENERGY COMPETITION ACQUISITION PLANNING COMPETITION REQUIREMENTS Full and Open Competition After Exclusion of Sources 906.202 Establishing or maintaining alternative sources. (b)(1) Every proposed contract...
48 CFR 2944.202 - Contracting officer's evaluation.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Contracting officer's evaluation. 2944.202 Section 2944.202 Federal Acquisition Regulations System DEPARTMENT OF LABOR CONTRACT MANAGEMENT SUBCONTRACTING POLICIES AND PROCEDURES Consent To Subcontract 2944.202 Contracting officer's...
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Policy. 624.202 Section 624.202 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS PROTECTION OF PRIVACY AND FREEDOM OF INFORMATION Freedom of Information Act 624.202 Policy. DOS regulations...
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Policy. 2824.202 Section 2824.202 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE Socioeconomic Programs PROTECTION OF PRIVACY AND FREEDOM OF INFORMATION Freedom of Information Act 2824.202 Policy. Procedures for...
Code of Federal Regulations, 2014 CFR
2014-10-01
... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Policy. 2024.202 Section 2024.202 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION SOCIOECONOMIC PROGRAMS PROTECTION OF PRIVACY AND FREEDOM OF INFORMATION Freedom of Information Act 2024.202 Policy. The provisions...
Code of Federal Regulations, 2012 CFR
2012-10-01
... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Policy. 2024.202 Section 2024.202 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION SOCIOECONOMIC PROGRAMS PROTECTION OF PRIVACY AND FREEDOM OF INFORMATION Freedom of Information Act 2024.202 Policy. The provisions...
Code of Federal Regulations, 2013 CFR
2013-10-01
... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Policy. 7.202 Section 7.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING ACQUISITION PLANNING Planning for the Purchase of Supplies in Economic Quantities 7.202 Policy. (a) Agencies...
Code of Federal Regulations, 2012 CFR
2012-10-01
... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Policy. 2824.202 Section 2824.202 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE SOCIOECONOMIC PROGRAMS PROTECTION OF PRIVACY AND FREEDOM OF INFORMATION Freedom of Information Act 2824.202 Policy. Procedures for...
Code of Federal Regulations, 2013 CFR
2013-10-01
... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Policy. 9.202 Section 9.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Qualifications Requirements 9.202 Policy. (a)(1) The head of the agency or designee...
Code of Federal Regulations, 2014 CFR
2014-10-01
... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Policy. 2824.202 Section 2824.202 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE SOCIOECONOMIC PROGRAMS PROTECTION OF PRIVACY AND FREEDOM OF INFORMATION Freedom of Information Act 2824.202 Policy. Procedures for...
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Policy. 7.202 Section 7.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING ACQUISITION PLANNING Planning for the Purchase of Supplies in Economic Quantities 7.202 Policy. (a) Agencies...
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Policy. 2024.202 Section 2024.202 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION SOCIOECONOMIC PROGRAMS PROTECTION OF PRIVACY AND FREEDOM OF INFORMATION Freedom of Information Act 2024.202 Policy. The provisions...
44 CFR 206.202 - Application procedures.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Application procedures. 206.202 Section 206.202 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY... Administration § 206.202 Application procedures. (a) General. This section describes the policies and procedures...
23 CFR 450.202 - Applicability.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 23 Highways 1 2012-04-01 2012-04-01 false Applicability. 450.202 Section 450.202 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Statewide Transportation Planning and Programming § 450.202 Applicability. The provisions of this...
23 CFR 450.202 - Applicability.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 23 Highways 1 2013-04-01 2013-04-01 false Applicability. 450.202 Section 450.202 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Statewide Transportation Planning and Programming § 450.202 Applicability. The provisions of this...
23 CFR 450.202 - Applicability.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 23 Highways 1 2014-04-01 2014-04-01 false Applicability. 450.202 Section 450.202 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Statewide Transportation Planning and Programming § 450.202 Applicability. The provisions of this...
5 CFR 339.202 - Medical standards.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Medical standards. 339.202 Section 339.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS MEDICAL QUALIFICATION DETERMINATIONS Physical and Medical Qualifications § 339.202 Medical standards. OPM may establish...
5 CFR 339.202 - Medical standards.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Medical standards. 339.202 Section 339.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS MEDICAL QUALIFICATION DETERMINATIONS Physical and Medical Qualifications § 339.202 Medical standards. OPM may establish...
5 CFR 339.202 - Medical standards.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Medical standards. 339.202 Section 339.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS MEDICAL QUALIFICATION DETERMINATIONS Physical and Medical Qualifications § 339.202 Medical standards. OPM may establish...
23 CFR 620.202 - Applicability.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 23 Highways 1 2010-04-01 2010-04-01 false Applicability. 620.202 Section 620.202 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS ENGINEERING Relinquishment of Highway Facilities § 620.202 Applicability. The provisions of this subpart apply to highway...
23 CFR 620.202 - Applicability.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 23 Highways 1 2011-04-01 2011-04-01 false Applicability. 620.202 Section 620.202 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS ENGINEERING Relinquishment of Highway Facilities § 620.202 Applicability. The provisions of this subpart apply to highway...
5 CFR 339.202 - Medical standards.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Medical standards. 339.202 Section 339.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS MEDICAL QUALIFICATION DETERMINATIONS Physical and Medical Qualifications § 339.202 Medical standards. OPM may establish...
5 CFR 339.202 - Medical standards.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Medical standards. 339.202 Section 339.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS MEDICAL QUALIFICATION DETERMINATIONS Physical and Medical Qualifications § 339.202 Medical standards. OPM may establish...
23 CFR 970.202 - Applicability.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 23 Highways 1 2012-04-01 2012-04-01 false Applicability. 970.202 Section 970.202 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL LANDS HIGHWAYS NATIONAL PARK SERVICE MANAGEMENT SYSTEMS National Park Service Management Systems § 970.202 Applicability. The provisions in this...
23 CFR 970.202 - Applicability.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 23 Highways 1 2011-04-01 2011-04-01 false Applicability. 970.202 Section 970.202 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL LANDS HIGHWAYS NATIONAL PARK SERVICE MANAGEMENT SYSTEMS National Park Service Management Systems § 970.202 Applicability. The provisions in this...
23 CFR 970.202 - Applicability.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 23 Highways 1 2013-04-01 2013-04-01 false Applicability. 970.202 Section 970.202 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL LANDS HIGHWAYS NATIONAL PARK SERVICE MANAGEMENT SYSTEMS National Park Service Management Systems § 970.202 Applicability. The provisions in this...
48 CFR 406.202 - Establishing or maintaining alternative sources.
Code of Federal Regulations, 2010 CFR
2010-10-01
... maintaining alternative sources. 406.202 Section 406.202 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE COMPETITION AND ACQUISITION PLANNING COMPETITION REQUIREMENTS Full and Open Competition After Exclusion of Sources 406.202 Establishing or maintaining alternative sources. The Senior Procurement...
48 CFR 1406.202 - Establishing or maintaining alternative sources.
Code of Federal Regulations, 2010 CFR
2010-10-01
... maintaining alternative sources. 1406.202 Section 1406.202 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR COMPETITION AND ACQUISITION PLANNING COMPETITION REQUIREMENTS Full and Open Competition After Exclusion of Sources 1406.202 Establishing or maintaining alternative sources. HCAs are...
48 CFR 1306.202 - Establishing or maintaining alternative sources.
Code of Federal Regulations, 2010 CFR
2010-10-01
... maintaining alternative sources. 1306.202 Section 1306.202 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE COMPETITION AND ACQUISITION PLANNING COMPETITION REQUIREMENTS Full and Open Competition After Exclusion of Sources 1306.202 Establishing or maintaining alternative sources. The authority to...
Code of Federal Regulations, 2010 CFR
2010-04-01
... 23 Highways 1 2010-04-01 2010-04-01 false Definitions. 633.202 Section 633.202 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS REQUIRED CONTRACT PROVISIONS Federal-Aid Contracts (Appalachian Contracts) § 633.202 Definitions. (a) The word Commission means...
48 CFR 411.202 - Maintenance of standardization documents.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Maintenance of standardization documents. 411.202 Section 411.202 Federal Acquisition Regulations System DEPARTMENT OF... Documents 411.202 Maintenance of standardization documents. Recommendations for changes to standardization...
48 CFR 30.202-6 - Responsibilities.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Responsibilities. 30.202-6 Section 30.202-6 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 30.202-6 Responsibilities. (a...
23 CFR 450.202 - Applicability.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 23 Highways 1 2011-04-01 2011-04-01 false Applicability. 450.202 Section 450.202 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Statewide Transportation Planning and Programming § 450.202 Applicability. The provisions of this...
40 CFR 246.202-1 - Requirement.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Requirement. 246.202-1 Section 246.202-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES SOURCE SEPARATION FOR MATERIALS RECOVERY GUIDELINES Requirements and Recommended Procedures § 246.202-1 Requirement...
40 CFR 246.202-1 - Requirement.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirement. 246.202-1 Section 246.202-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES SOURCE SEPARATION FOR MATERIALS RECOVERY GUIDELINES Requirements and Recommended Procedures § 246.202-1 Requirement...
40 CFR 246.202-1 - Requirement.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirement. 246.202-1 Section 246.202-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES SOURCE SEPARATION FOR MATERIALS RECOVERY GUIDELINES Requirements and Recommended Procedures § 246.202-1 Requirement...
23 CFR 810.202 - Applicability.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 23 Highways 1 2010-04-01 2010-04-01 false Applicability. 810.202 Section 810.202 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PUBLIC TRANSPORTATION MASS TRANSIT AND SPECIAL USE HIGHWAY PROJECTS Making Highway Rights-of-Way Available for Mass Transit Projects § 810.202 Applicability...
5 CFR 362.202 - Announcement, nomination, and selection.
Code of Federal Regulations, 2010 CFR
2010-01-01
... for, as well as a clear interest in and commitment to, leadership in the analysis and management of.... 362.202 Section 362.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PRESIDENTIAL MANAGEMENT FELLOWS PROGRAM Program Administration § 362.202 Announcement, nomination...
48 CFR 246.202-4 - Higher-level contract quality requirements.
Code of Federal Regulations, 2010 CFR
2010-10-01
... quality requirements. 246.202-4 Section 246.202-4 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Quality Requirements 246.202-4 Higher-level contract quality requirements. (1) Higher-level contract quality...
Code of Federal Regulations, 2012 CFR
2012-04-01
... 19 Customs Duties 3 2012-04-01 2012-04-01 false Reports. 202.6 Section 202.6 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.6 Reports. After the completion of its investigation, the Commission will incorporate its...
Code of Federal Regulations, 2011 CFR
2011-04-01
... 19 Customs Duties 3 2011-04-01 2011-04-01 false Reports. 202.6 Section 202.6 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.6 Reports. After the completion of its investigation, the Commission will incorporate its...
5 CFR 950.202 - National/international eligibility requirements.
Code of Federal Regulations, 2011 CFR
2011-01-01
... CONTRIBUTIONS TO PRIVATE VOLUNTARY ORGANIZATIONS Eligibility Provisions § 950.202 National/international... requirements. 950.202 Section 950.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL.... Location of residence of organization members or location of residence of visitors to a facility does not...
5 CFR 950.202 - National/international eligibility requirements.
Code of Federal Regulations, 2013 CFR
2013-01-01
... CONTRIBUTIONS TO PRIVATE VOLUNTARY ORGANIZATIONS Eligibility Provisions § 950.202 National/international... requirements. 950.202 Section 950.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL.... Location of residence of organization members or location of residence of visitors to a facility does not...
5 CFR 950.202 - National/international eligibility requirements.
Code of Federal Regulations, 2012 CFR
2012-01-01
... CONTRIBUTIONS TO PRIVATE VOLUNTARY ORGANIZATIONS Eligibility Provisions § 950.202 National/international... requirements. 950.202 Section 950.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL.... Location of residence of organization members or location of residence of visitors to a facility does not...
5 CFR 950.202 - National/international eligibility requirements.
Code of Federal Regulations, 2014 CFR
2014-01-01
... CONTRIBUTIONS TO PRIVATE VOLUNTARY ORGANIZATIONS Eligibility Provisions § 950.202 National/international... requirements. 950.202 Section 950.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL.... Location of residence of organization members or location of residence of visitors to a facility does not...
Code of Federal Regulations, 2013 CFR
2013-01-01
... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Definitions. 362.202 Section 362.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PATHWAYS PROGRAMS Internship Program § 362.202 Definitions. In this subpart: Student means an individual accepted for enrollment or...
Code of Federal Regulations, 2014 CFR
2014-01-01
... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Definitions. 362.202 Section 362.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PATHWAYS PROGRAMS Internship Program § 362.202 Definitions. In this subpart: Student means an individual accepted for enrollment or...
23 CFR 635.202 - Applicability.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 23 Highways 1 2011-04-01 2011-04-01 false Applicability. 635.202 Section 635.202 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS CONSTRUCTION AND MAINTENANCE Force Account Construction § 635.202 Applicability. This subpart applies to all Federal-aid and...
23 CFR 635.202 - Applicability.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 23 Highways 1 2012-04-01 2012-04-01 false Applicability. 635.202 Section 635.202 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS CONSTRUCTION AND MAINTENANCE Force Account Construction § 635.202 Applicability. This subpart applies to all Federal-aid and...
23 CFR 635.202 - Applicability.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 23 Highways 1 2010-04-01 2010-04-01 false Applicability. 635.202 Section 635.202 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS CONSTRUCTION AND MAINTENANCE Force Account Construction § 635.202 Applicability. This subpart applies to all Federal-aid and...
23 CFR 635.202 - Applicability.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 23 Highways 1 2013-04-01 2013-04-01 false Applicability. 635.202 Section 635.202 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS CONSTRUCTION AND MAINTENANCE Force Account Construction § 635.202 Applicability. This subpart applies to all Federal-aid and...
23 CFR 635.202 - Applicability.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 23 Highways 1 2014-04-01 2014-04-01 false Applicability. 635.202 Section 635.202 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS CONSTRUCTION AND MAINTENANCE Force Account Construction § 635.202 Applicability. This subpart applies to all Federal-aid and...
48 CFR 9903.202-3 - Amendments and revisions.
Code of Federal Regulations, 2010 CFR
2010-10-01
.... 9903.202-3 Section 9903.202-3 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD... ACCOUNTING STANDARDS CONTRACT COVERAGE CAS Program Requirements 9903.202-3 Amendments and revisions..., Disclosure Statements is discouraged except when extensive changes require it to assist the review process. ...
48 CFR 813.202 - Purchase guidelines.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Purchase guidelines. 813.202 Section 813.202 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACTING... Threshold 813.202 Purchase guidelines. Open market micro-purchases shall be equitably distributed among all...
40 CFR 240.202 - Site selection.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Site selection. 240.202 Section 240.202 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.202 Site...
48 CFR 2406.202 - Establishing or maintaining alternative sources.
Code of Federal Regulations, 2010 CFR
2010-10-01
... alternative sources. 2406.202 Section 2406.202 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT COMPETITION AND ACQUISITION PLANNING COMPETITION REQUIREMENTS Full and Open Competition After Exclusion of Sources 2406.202 Establishing or maintaining alternative sources. (b)(1) The...
48 CFR 606.202 - Establishing or maintaining alternate sources.
Code of Federal Regulations, 2010 CFR
2010-10-01
... maintaining alternate sources. 606.202 Section 606.202 Federal Acquisition Regulations System DEPARTMENT OF STATE COMPETITION AND ACQUISITION PLANNING COMPETITION REQUIREMENTS Full and Open Competition After Exclusion of Sources 606.202 Establishing or maintaining alternate sources. The Procurement Executive is the...
14 CFR 1212.202 - Identification procedures.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Identification procedures. 1212.202 Section 1212.202 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS Access to Records § 1212.202 Identification procedures. (a) The system manager will release...
14 CFR 1212.202 - Identification procedures.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Identification procedures. 1212.202 Section 1212.202 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS Access to Records § 1212.202 Identification procedures. (a) The system manager will release...
48 CFR 430.202-8 - Subcontractor Disclosure Statements.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Subcontractor Disclosure Statements. 430.202-8 Section 430.202-8 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 430.202...
48 CFR 30.202-2 - Impracticality of submission.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Impracticality of submission. 30.202-2 Section 30.202-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 30.202...
48 CFR 30.202-1 - General requirements.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false General requirements. 30.202-1 Section 30.202-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 30.202-1 General...
48 CFR 430.202-2 - Impracticality of submission.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Impracticality of submission. 430.202-2 Section 430.202-2 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 430.202...
48 CFR 30.202-8 - Subcontractor disclosure statements.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Subcontractor disclosure statements. 30.202-8 Section 30.202-8 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 30.202...
48 CFR 30.202-5 - Filing disclosure statements.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Filing disclosure statements. 30.202-5 Section 30.202-5 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 30.202...
48 CFR 30.202-3 - Amendments and revisions.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Amendments and revisions. 30.202-3 Section 30.202-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 30.202...
47 CFR 15.202 - Certified operating frequency range.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 47 Telecommunication 1 2010-10-01 2010-10-01 false Certified operating frequency range. 15.202 Section 15.202 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Intentional Radiators § 15.202 Certified operating frequency range. Client devices that operate in a master...
48 CFR 1442.202 - Assignment of contract administration.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Assignment of contract administration. 1442.202 Section 1442.202 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Contract Administration Services 1442.202...
48 CFR 48.202 - Clause for construction contracts.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Clause for construction contracts. 48.202 Section 48.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT VALUE ENGINEERING Contract Clauses 48.202 Clause for construction contracts. The...
Genotoxicity of 11 heavy metals detected as food contaminants in two human cell lines.
Kopp, B; Zalko, D; Audebert, M
2018-04-01
Heavy metals, such as arsenic (As), antimony (Sb), barium (Ba), cadmium (Cd), cobalt (Co), germanium (Ge), lead (Pb), nickel (Ni), tellurium (Te), and vanadium (V) are widely distributed in the environment and in the food chain. Human exposure to heavy metals through water and food has been reported by different international agencies. Although some of these heavy metals are essential elements for human growth and development, they may also be toxic at low concentrations due to indirect mechanisms. In this study, the genotoxic and cytotoxic properties of 15 different oxidation statuses of 11 different heavy metals were investigated using high-throughput screening (γH2AX assay) in two human cell lines (HepG2 and LS-174T) representative of target organs (liver and colon) for food contaminants. Base on their lowest observed adverse effect concentration, the genotoxic potency of each heavy metal in each cell line was ranked in decreasing order, NaAsO 2 > CdCl 2 > PbCl 2 (only in LS-174T cells) > As 2 O 5 > SbCl 3 > K 2 TeO 3 > As 2 O 3 . No significant genotoxicity was observed with the other heavy metals tested. Cell viability data indicate that several heavy metals (As, Cd, Co, Ni, Sb, and Te) induce cytotoxicity at high concentrations, whereas an increase in the number of cells was observed for lead concentrations >100 µM in both cell lines tested, suggesting that lead stimulates cell growth. All these results highlight the possible human health hazards associated with the presence of heavy metals present in food. Environ. Mol. Mutagen. 59:202-210, 2018. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.
Pharmaceuticals and other contaminants of emerging concern in landfill leachate of the United States
Kolpin, Dana W.; Masoner, Jason R.; Furlong, Edward T.; Cozzarelli, Isabelle M.; Gray, James L.; Schwab, Eric A.
2015-01-01
Landfills are commonly the final respository for a heterogeneous mixture of waste from residential, commercial, and industrial sources. The use of landfills as a means of waste disposal will likely increase as the global population increases and nations develop. Thus, landfills receiving such waste have the potential to produce leachate containing numerous organic chemicals including contaminants of emerging concern (CECs) such as pharmaceuticals, personal care products, and hormones. This leachate is often discharged to pathways that lead directly (e.g. groundwater, streams) or indirectly (e.g. wastewater treament plants) to the environment. Limited research, however, has been conducted regarding the characterisation of landfill leachate for CECs.To provide the first national-scale assessment of CECs in landfill leachate across the United States, fresh leachate samples (i.e. prior to onsite treatment) from 19 landfills in 16 states were collected in 2011 and analysed for 202 CECs [1]. The targeted CECs were selected for analysis because they were expected to be persistent in the environment; are used, excreted, or disposed of in substantial quantities; may have human or environmental health effects; or are potential indicators of environmentally relevant classes of chemicals or source materials.
Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells.
Boice, Michael; Salloum, Darin; Mourcin, Frederic; Sanghvi, Viraj; Amin, Rada; Oricchio, Elisa; Jiang, Man; Mottok, Anja; Denis-Lagache, Nicolas; Ciriello, Giovanni; Tam, Wayne; Teruya-Feldstein, Julie; de Stanchina, Elisa; Chan, Wing C; Malek, Sami N; Ennishi, Daisuke; Brentjens, Renier J; Gascoyne, Randy D; Cogné, Michel; Tarte, Karin; Wendel, Hans-Guido
2016-10-06
The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in germinal center lymphomas. We report that loss of HVEM leads to cell-autonomous activation of B cell proliferation and drives the development of GC lymphomas in vivo. HVEM-deficient lymphoma B cells also induce a tumor-supportive microenvironment marked by exacerbated lymphoid stroma activation and increased recruitment of T follicular helper (T FH ) cells. These changes result from the disruption of inhibitory cell-cell interactions between the HVEM and BTLA (B and T lymphocyte attenuator) receptors. Accordingly, administration of the HVEM ectodomain protein (solHVEM (P37-V202) ) binds BTLA and restores tumor suppression. To deliver solHVEM to lymphomas in vivo, we engineered CD19-targeted chimeric antigen receptor (CAR) T cells that produce solHVEM locally and continuously. These modified CAR-T cells show enhanced therapeutic activity against xenografted lymphomas. Hence, the HVEM-BTLA axis opposes lymphoma development, and our study illustrates the use of CAR-T cells as "micro-pharmacies" able to deliver an anti-cancer protein. Copyright © 2016 Elsevier Inc. All rights reserved.
Defense Transportation Regulation Part 2, Cargo Movement.
1998-08-01
Stop-Off Unloading Point (DD Form 1371) 202-18 202-7 Route Order Amendment (DD Form 2017 ) 202-19 204-1 Hazardous Materials Classification...DRO/IRO/SRO amendments will be submitted to the appropriate MTMC routing authority or theater CINC using DD Form 2017 , Route Order Amendment...Figure 202-5. 7. An example of a DD Form 2017 , Route Order Amendment, is provided in Figure 202.7. D. EXCEPTION Exceptions to assignment of routing
48 CFR 9903.202-4 - Privileged and confidential information.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Privileged and confidential information. 9903.202-4 Section 9903.202-4 Federal Acquisition Regulations System COST ACCOUNTING... AND COST ACCOUNTING STANDARDS CONTRACT COVERAGE CAS Program Requirements 9903.202-4 Privileged and...
40 CFR 240.202-1 - Requirement.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirement. 240.202-1 Section 240.202-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.202-1 Requirement...
40 CFR 240.202-1 - Requirement.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirement. 240.202-1 Section 240.202-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.202-1 Requirement...
7 CFR 1580.202 - Hearings, petition reviews, and amendments.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 7 Agriculture 10 2011-01-01 2011-01-01 false Hearings, petition reviews, and amendments. 1580.202 Section 1580.202 Agriculture Regulations of the Department of Agriculture (Continued) FOREIGN AGRICULTURAL SERVICE, DEPARTMENT OF AGRICULTURE TRADE ADJUSTMENT ASSISTANCE FOR FARMERS § 1580.202 Hearings, petition...
40 CFR 265.202 - Air emission standards.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Air emission standards. 265.202 Section 265.202 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... DISPOSAL FACILITIES Tank Systems § 265.202 Air emission standards. The owner or operator shall manage all...
40 CFR 265.202 - Air emission standards.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Air emission standards. 265.202 Section 265.202 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... DISPOSAL FACILITIES Tank Systems § 265.202 Air emission standards. The owner or operator shall manage all...
19 CFR 202.3 - Preliminary inquiry.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 19 Customs Duties 3 2010-04-01 2010-04-01 false Preliminary inquiry. 202.3 Section 202.3 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.3 Preliminary inquiry. Upon the receipt of an application properly filed, the...
19 CFR 202.3 - Preliminary inquiry.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 19 Customs Duties 3 2011-04-01 2011-04-01 false Preliminary inquiry. 202.3 Section 202.3 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.3 Preliminary inquiry. Upon the receipt of an application properly filed, the...
19 CFR 202.3 - Preliminary inquiry.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 19 Customs Duties 3 2014-04-01 2014-04-01 false Preliminary inquiry. 202.3 Section 202.3 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.3 Preliminary inquiry. Upon the receipt of an application properly filed, the...
19 CFR 202.3 - Preliminary inquiry.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 19 Customs Duties 3 2012-04-01 2012-04-01 false Preliminary inquiry. 202.3 Section 202.3 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.3 Preliminary inquiry. Upon the receipt of an application properly filed, the...
19 CFR 202.3 - Preliminary inquiry.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 19 Customs Duties 3 2013-04-01 2013-04-01 false Preliminary inquiry. 202.3 Section 202.3 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.3 Preliminary inquiry. Upon the receipt of an application properly filed, the...
Code of Federal Regulations, 2010 CFR
2010-07-01
... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Definitions. 20.2 Section 20.2 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MINE LAMPS OTHER THAN STANDARD CAP LAMPS § 20.2 Definitions. (a) Adequate...
Federal Register 2010, 2011, 2012, 2013, 2014
2010-11-09
... Independence Avenue, SW., Washington, DC 20250-0781 or by telephone at (202) 720-1094 or (202) 720-1610, TDD... Loan Division, Multi- Family Housing STOP 0781 (Room 1263-S) or by telephone at (202) 720- 1094 or (202...
48 CFR 43.202 - Authority to issue change orders.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Authority to issue change orders. 43.202 Section 43.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 43.202 Authority to issue change orders. Change...
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 3 2010-01-01 2010-01-01 false Definitions. 202.2 Section 202.2 Agriculture... RULES OF PRACTICE General § 202.2 Definitions. For the purposes of this part, the following terms shall... 20250. (j) The term person includes any individual, partnership, corporation, company, society...
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 1 2010-01-01 2010-01-01 false Administration. 20.2 Section 20.2 Agriculture Office of the Secretary of Agriculture EXPORT SALES REPORTING REQUIREMENTS § 20.2 Administration. The regulations of this part will be administered by the Foreign Agricultural Service (FAS) under the general...
40 CFR 265.202 - Air emission standards.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Air emission standards. 265.202 Section 265.202 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... DISPOSAL FACILITIES Tank Systems § 265.202 Air emission standards. The owner or operator shall manage all...
40 CFR 265.202 - Air emission standards.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Air emission standards. 265.202 Section 265.202 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... DISPOSAL FACILITIES Tank Systems § 265.202 Air emission standards. The owner or operator shall manage all...
40 CFR 246.202-5 - Recommended procedures: Transportation.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Recommended procedures: Transportation. 246.202-5 Section 246.202-5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... § 246.202-5 Recommended procedures: Transportation. Transportation to market may be supplied by either...
40 CFR 246.202-5 - Recommended procedures: Transportation.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Recommended procedures: Transportation. 246.202-5 Section 246.202-5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... § 246.202-5 Recommended procedures: Transportation. Transportation to market may be supplied by either...
40 CFR 246.202-5 - Recommended procedures: Transportation.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Recommended procedures: Transportation. 246.202-5 Section 246.202-5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... § 246.202-5 Recommended procedures: Transportation. Transportation to market may be supplied by either...
40 CFR 246.202-5 - Recommended procedures: Transportation.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Recommended procedures: Transportation. 246.202-5 Section 246.202-5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... § 246.202-5 Recommended procedures: Transportation. Transportation to market may be supplied by either...
30 CFR 202.352 - Minimum royalty.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Minimum royalty. 202.352 Section 202.352 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT ROYALTIES Geothermal Resources § 202.352 Minimum royalty. In no event shall the lessee's annual royalty...
40 CFR 272.202-272.249 - [Reserved
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 27 2014-07-01 2014-07-01 false [Reserved] 272.202-272.249 Section 272.202-272.249 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Arkansas §§ 272.202-272.249 [Reserved] ...
40 CFR 272.202-272.249 - [Reserved
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 27 2011-07-01 2011-07-01 false [Reserved] 272.202-272.249 Section 272.202-272.249 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Arkansas §§ 272.202-272.249 [Reserved] ...
40 CFR 272.202-272.249 - [Reserved
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 28 2012-07-01 2012-07-01 false [Reserved] 272.202-272.249 Section 272.202-272.249 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Arkansas §§ 272.202-272.249 [Reserved] ...
40 CFR 272.202-272.249 - [Reserved
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 28 2013-07-01 2013-07-01 false [Reserved] 272.202-272.249 Section 272.202-272.249 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Arkansas §§ 272.202-272.249 [Reserved] ...
40 CFR 240.202-1 - Requirement.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirement. 240.202-1 Section 240.202-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.202-1 Requirement...
48 CFR 214.202-5 - Descriptive literature.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Descriptive literature. 214.202-5 Section 214.202-5 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... 214.202-5 Descriptive literature. (c) Requirements of invitation for bids. When brand name or equal...
48 CFR 214.202-5 - Descriptive literature.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Descriptive literature. 214.202-5 Section 214.202-5 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... 214.202-5 Descriptive literature. (c) Requirements of invitation for bids. When brand name or equal...
48 CFR 214.202-5 - Descriptive literature.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Descriptive literature. 214.202-5 Section 214.202-5 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... 214.202-5 Descriptive literature. (c) Requirements of invitation for bids. When brand name or equal...
48 CFR 214.202-5 - Descriptive literature.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Descriptive literature. 214.202-5 Section 214.202-5 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... 214.202-5 Descriptive literature. (c) Requirements of invitation for bids. When brand name or equal...
48 CFR 214.202-5 - Descriptive literature.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Descriptive literature. 214.202-5 Section 214.202-5 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... 214.202-5 Descriptive literature. (c) Requirements of invitation for bids. When brand name or equal...
40 CFR 240.202-1 - Requirement.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Requirement. 240.202-1 Section 240.202-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.202-1 Requirement...
48 CFR 206.202 - Establishing or maintaining alternative sources.
Code of Federal Regulations, 2010 CFR
2010-10-01
... Open Competition After Exclusion of Sources 206.202 Establishing or maintaining alternative sources. (a) Agencies may use this authority to totally or partially exclude a particular source from a contract action... maintaining alternative sources. 206.202 Section 206.202 Federal Acquisition Regulations System DEFENSE...
18 CFR 270.202 - Definition of determination.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Definition of determination. 270.202 Section 270.202 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... PROCEDURES Determinations by Jurisdictional Agencies § 270.202 Definition of determination. For purposes of...
7 CFR 1580.202 - Hearings, petition reviews, and amendments.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 10 2010-01-01 2010-01-01 false Hearings, petition reviews, and amendments. 1580.202 Section 1580.202 Agriculture Regulations of the Department of Agriculture (Continued) FOREIGN AGRICULTURAL SERVICE, DEPARTMENT OF AGRICULTURE TRADE ADJUSTMENT ASSISTANCE FOR FARMERS § 1580.202 Hearings, petition...
46 CFR 308.202 - Issuance of interim binder; terms and conditions.
Code of Federal Regulations, 2011 CFR
2011-10-01
....202 Section 308.202 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.202 Issuance of interim... terms, conditions, and warranties contained in the application for war risk protection and indemnity...
46 CFR 308.202 - Issuance of interim binder; terms and conditions.
Code of Federal Regulations, 2013 CFR
2013-10-01
....202 Section 308.202 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.202 Issuance of interim... terms, conditions, and warranties contained in the application for war risk protection and indemnity...
46 CFR 308.202 - Issuance of interim binder; terms and conditions.
Code of Federal Regulations, 2012 CFR
2012-10-01
....202 Section 308.202 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.202 Issuance of interim... terms, conditions, and warranties contained in the application for war risk protection and indemnity...
46 CFR 308.202 - Issuance of interim binder; terms and conditions.
Code of Federal Regulations, 2010 CFR
2010-10-01
....202 Section 308.202 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.202 Issuance of interim... terms, conditions, and warranties contained in the application for war risk protection and indemnity...
46 CFR 308.202 - Issuance of interim binder; terms and conditions.
Code of Federal Regulations, 2014 CFR
2014-10-01
....202 Section 308.202 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.202 Issuance of interim... terms, conditions, and warranties contained in the application for war risk protection and indemnity...
40 CFR 272.202-272.249 - [Reserved
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 26 2010-07-01 2010-07-01 false [Reserved] 272.202-272.249 Section 272.202-272.249 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Arkansas §§ 272.202-272.249 [Reserved] ...
Code of Federal Regulations, 2010 CFR
2010-10-01
... 42 Public Health 1 2010-10-01 2010-10-01 false Definitions. 66.202 Section 66.202 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Institutional Grants § 66.202 Definitions. The definitions in § 66.102 of...
Code of Federal Regulations, 2012 CFR
2012-10-01
... 42 Public Health 1 2012-10-01 2012-10-01 false Definitions. 66.202 Section 66.202 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Institutional Grants § 66.202 Definitions. The definitions in § 66.102 of...
Code of Federal Regulations, 2011 CFR
2011-10-01
... 42 Public Health 1 2011-10-01 2011-10-01 false Definitions. 66.202 Section 66.202 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Institutional Grants § 66.202 Definitions. The definitions in § 66.102 of...
48 CFR 9903.202-8 - Subcontractor Disclosure Statements.
Code of Federal Regulations, 2010 CFR
2010-10-01
... Statements. 9903.202-8 Section 9903.202-8 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS... COST ACCOUNTING STANDARDS CONTRACT COVERAGE CAS Program Requirements 9903.202-8 Subcontractor.... Instead, the ACO cognizant of the subcontractor shall (i) Notify the auditor that the adequacy review will...
Code of Federal Regulations, 2011 CFR
2011-01-01
... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Coverage. 531.202 Section 531.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY UNDER THE GENERAL SCHEDULE Determining Rate of Basic Pay General Provisions § 531.202 Coverage. This subpart covers employees who occupy...
Code of Federal Regulations, 2010 CFR
2010-01-01
... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Coverage. 430.202 Section 430.202... Performance Appraisal for General Schedule, Prevailing Rate, and Certain Other Employees § 430.202 Coverage..., coverage includes, but is not limited to, senior-level and scientific and professional employees paid under...
Code of Federal Regulations, 2011 CFR
2011-01-01
... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Coverage. 9901.202 Section 9901.202... (NSPS) Classification General § 9901.202 Coverage. (a) This subpart applies to eligible DoD employees... functional units are eligible for coverage under this subpart: (1) Employees and positions that would...
Code of Federal Regulations, 2014 CFR
2014-01-01
... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Coverage. 430.202 Section 430.202... Performance Appraisal for General Schedule, Prevailing Rate, and Certain Other Employees § 430.202 Coverage..., coverage includes, but is not limited to, senior-level and scientific and professional employees paid under...
Code of Federal Regulations, 2010 CFR
2010-01-01
... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Coverage. 9901.202 Section 9901.202... (NSPS) Classification General § 9901.202 Coverage. (a) This subpart applies to eligible DoD employees... functional units are eligible for coverage under this subpart: (1) Employees and positions that would...
Code of Federal Regulations, 2013 CFR
2013-01-01
... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Coverage. 531.202 Section 531.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY UNDER THE GENERAL SCHEDULE Determining Rate of Basic Pay General Provisions § 531.202 Coverage. This subpart covers employees who occupy...
Code of Federal Regulations, 2011 CFR
2011-01-01
... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Coverage. 430.202 Section 430.202... Performance Appraisal for General Schedule, Prevailing Rate, and Certain Other Employees § 430.202 Coverage..., coverage includes, but is not limited to, senior-level and scientific and professional employees paid under...
Code of Federal Regulations, 2013 CFR
2013-01-01
... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Coverage. 430.202 Section 430.202... Performance Appraisal for General Schedule, Prevailing Rate, and Certain Other Employees § 430.202 Coverage..., coverage includes, but is not limited to, senior-level and scientific and professional employees paid under...
Code of Federal Regulations, 2012 CFR
2012-01-01
... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Coverage. 531.202 Section 531.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY UNDER THE GENERAL SCHEDULE Determining Rate of Basic Pay General Provisions § 531.202 Coverage. This subpart covers employees who occupy...
Code of Federal Regulations, 2012 CFR
2012-01-01
... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Coverage. 430.202 Section 430.202... Performance Appraisal for General Schedule, Prevailing Rate, and Certain Other Employees § 430.202 Coverage..., coverage includes, but is not limited to, senior-level and scientific and professional employees paid under...
Code of Federal Regulations, 2010 CFR
2010-01-01
... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Coverage. 531.202 Section 531.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY UNDER THE GENERAL SCHEDULE Determining Rate of Basic Pay General Provisions § 531.202 Coverage. This subpart covers employees who occupy...
Code of Federal Regulations, 2014 CFR
2014-01-01
... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Coverage. 531.202 Section 531.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY UNDER THE GENERAL SCHEDULE Determining Rate of Basic Pay General Provisions § 531.202 Coverage. This subpart covers employees who occupy...
24 CFR 888.202 - Manner of publication.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false Manner of publication. 888.202 Section 888.202 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT... ADJUSTMENT FACTORS Contract Rent Annual Adjustment Factors § 888.202 Manner of publication. Adjustment...
48 CFR 46.202-4 - Higher-level contract quality requirements.
Code of Federal Regulations, 2013 CFR
2013-10-01
... quality requirements. 46.202-4 Section 46.202-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Quality Requirements 46.202-4 Higher-level contract quality requirements. (a) Requiring compliance with higher-level quality standards is appropriate in...
48 CFR 46.202-4 - Higher-level contract quality requirements.
Code of Federal Regulations, 2012 CFR
2012-10-01
... quality requirements. 46.202-4 Section 46.202-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Quality Requirements 46.202-4 Higher-level contract quality requirements. (a) Requiring compliance with higher-level quality standards is appropriate in...
48 CFR 46.202-4 - Higher-level contract quality requirements.
Code of Federal Regulations, 2011 CFR
2011-10-01
... quality requirements. 46.202-4 Section 46.202-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Quality Requirements 46.202-4 Higher-level contract quality requirements. (a) Requiring compliance with higher-level quality standards is appropriate in...
48 CFR 46.202-4 - Higher-level contract quality requirements.
Code of Federal Regulations, 2014 CFR
2014-10-01
... quality requirements. 46.202-4 Section 46.202-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Quality Requirements 46.202-4 Higher-level contract quality requirements. (a) Requiring compliance with higher-level quality standards is appropriate in...
48 CFR 43.202 - Authority to issue change orders.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Authority to issue change orders. 43.202 Section 43.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 43.202 Authority to issue change orders. Change...
5 CFR 891.202 - Change of election.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Change of election. 891.202 Section 891.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIRED FEDERAL EMPLOYEES HEALTH BENEFITS Election and Change of Election § 891.202 Change of...
Schottelius, Margret; Osl, Theresa; Poschenrieder, Andreas; Hoffmann, Frauke; Beykan, Seval; Hänscheid, Heribert; Schirbel, Andreas; Buck, Andreas K.; Kropf, Saskia; Schwaiger, Markus; Keller, Ulrich; Lassmann, Michael; Wester, Hans-Jürgen
2017-01-01
Purpose: Based on the clinical relevance of the chemokine receptor 4 (CXCR4) as a molecular target in cancer and on the success of [68Ga]pentixafor as an imaging probe for high-contrast visualization of CXCR4-expression, the spectrum of clinical CXCR4-targeting was expanded towards peptide receptor radionuclide therapy (PRRT) by the development of [177Lu]pentixather. Experimental design: CXCR4 affinity, binding specificity, hCXCR4 selectivity and internalization efficiency of [177Lu]pentixather were evaluated using different human and murine cancer cell lines. Biodistribution studies (1, 6, 48, 96h and 7d p.i.) and in vivo metabolite analyses were performed using Daudi-lymphoma bearing SCID mice. Extrapolated organ doses were cross-validated with human dosimetry (pre-therapeutic and during [177Lu]pentixather PRRT) in a patient with multiple myeloma (MM). Results: [177Lu]pentixather binds with high affinity, specificity and selectivity to hCXCR4 and shows excellent in vivo stability. Consequently, and supported by >96% plasma protein binding and a logP=-1.76, delaying whole-body clearance of [177Lu]pentixather, tumor accumulation was high and persistent, both in the Daudi model and the MM patient. Tumor/background ratios (7d p.i.) in mice were 499±202, 33±7, 4.0±0.8 and 116±22 for blood, intestine, kidney and muscle, respectively. In the patient, high tumor/kidney and tumor/liver dose ratios of 3.1 and 6.4 were observed during [177Lu]pentixather PRRT (7.8 GBq), with the kidneys being the dose-limiting organs. Conclusions: [177Lu]pentixather shows excellent in vivo CXCR4-targeting characteristics and a suitable pharmacokinetic profile, leading to high tumor uptake and retention and thus high radiation doses to tumor tissue during PRRT, suggesting high clinical potential of this [68Ga]pentixafor/[177Lu]pentixather based CXCR4-targeted theranostic concept. PMID:28744319
Lithium-Ion Battery Failure: Effects of State of Charge and Packing Configuration
2016-08-22
Naval Research Laboratory Washington, DC 20375-5320 NRL/MR/6180--16-9689 Lithium - Ion Battery Failure: Effects of State of Charge and Packing...PAGES 17. LIMITATION OF ABSTRACT Lithium - Ion Battery Failure: Effects of State of Charge and Packing Configuration Neil S. Spinner,* Katherine M. Hinnant...Steven G. Tuttle (202) 404-3419 Lithium - ion battery safety remains a significant concern, as battery failure leads to ejection of hazardous materials
20 CFR 202.14 - Service incidental to railroad transportation.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Service incidental to railroad transportation. 202.14 Section 202.14 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT EMPLOYERS UNDER THE ACT § 202.14 Service incidental to railroad transportation. An...
22 CFR 202.10 - Participation by faith-based organizations.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Participation by faith-based organizations. 202.10 Section 202.10 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT OVERSEAS SHIPMENTS OF SUPPLIES BY VOLUNTARY NON-PROFIT RELIEF AGENCIES § 202.10 Participation by faith-based organizations. The...
22 CFR 202.10 - Participation by faith-based organizations.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Participation by faith-based organizations. 202.10 Section 202.10 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT OVERSEAS SHIPMENTS OF SUPPLIES BY VOLUNTARY NON-PROFIT RELIEF AGENCIES § 202.10 Participation by faith-based organizations. The...
22 CFR 202.10 - Participation by faith-based organizations.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Participation by faith-based organizations. 202.10 Section 202.10 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT OVERSEAS SHIPMENTS OF SUPPLIES BY VOLUNTARY NON-PROFIT RELIEF AGENCIES § 202.10 Participation by faith-based organizations. The...
22 CFR 202.10 - Participation by faith-based organizations.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Participation by faith-based organizations. 202.10 Section 202.10 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT OVERSEAS SHIPMENTS OF SUPPLIES BY VOLUNTARY NON-PROFIT RELIEF AGENCIES § 202.10 Participation by faith-based organizations. The...
22 CFR 202.10 - Participation by faith-based organizations.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Participation by faith-based organizations. 202.10 Section 202.10 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT OVERSEAS SHIPMENTS OF SUPPLIES BY VOLUNTARY NON-PROFIT RELIEF AGENCIES § 202.10 Participation by faith-based organizations. The...
50 CFR 217.202 - Permissible methods of taking.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 50 Wildlife and Fisheries 10 2012-10-01 2012-10-01 false Permissible methods of taking. 217.202 Section 217.202 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC... Redevelopment Project § 217.202 Permissible methods of taking. (a) Under Letters of Authorization issued...
50 CFR 217.202 - Permissible methods of taking.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 50 Wildlife and Fisheries 10 2013-10-01 2013-10-01 false Permissible methods of taking. 217.202 Section 217.202 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC... Redevelopment Project § 217.202 Permissible methods of taking. (a) Under Letters of Authorization issued...
24 CFR 941.202 - Site and neighborhood standards.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false Site and neighborhood standards. 941.202 Section 941.202 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN... URBAN DEVELOPMENT PUBLIC HOUSING DEVELOPMENT PHA Eligibility and Program Requirements § 941.202 Site and...
24 CFR 941.202 - Site and neighborhood standards.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false Site and neighborhood standards. 941.202 Section 941.202 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN... URBAN DEVELOPMENT PUBLIC HOUSING DEVELOPMENT PHA Eligibility and Program Requirements § 941.202 Site and...
75 FR 10794 - Clean Air Act Advisory Committee (CAAAC) Request for Nominations to the CAAAC
Federal Register 2010, 2011, 2012, 2013, 2014
2010-03-09
... Ave., Washington, DC 20004, T: 202 564-1082, F: 202 564- 1352, e-mail [email protected] . FOR... (202) 564-1082, FAX (202) 564-1352 or by mail at US EPA, Office of Air and Radiation (Mail code 6102 A...
30 CFR 202.53 - Minimum royalty.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Minimum royalty. 202.53 Section 202.53 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT ROYALTIES Oil, Gas, and OCS Sulfur, General § 202.53 Minimum royalty. For leases that provide for minimum royalty...
32 CFR 202.5 - Creating a mission statement.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 32 National Defense 2 2010-07-01 2010-07-01 false Creating a mission statement. 202.5 Section 202.5 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS RESTORATION ADVISORY BOARDS Operating Requirements § 202.5 Creating a mission statement. The...
42 CFR 460.202 - Participant health outcomes data.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 42 Public Health 4 2010-10-01 2010-10-01 false Participant health outcomes data. 460.202 Section 460.202 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... FOR THE ELDERLY (PACE) Data Collection, Record Maintenance, and Reporting § 460.202 Participant health...
42 CFR 460.202 - Participant health outcomes data.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 42 Public Health 4 2014-10-01 2014-10-01 false Participant health outcomes data. 460.202 Section 460.202 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... FOR THE ELDERLY (PACE) Data Collection, Record Maintenance, and Reporting § 460.202 Participant health...
42 CFR 460.202 - Participant health outcomes data.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 42 Public Health 4 2011-10-01 2011-10-01 false Participant health outcomes data. 460.202 Section 460.202 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... FOR THE ELDERLY (PACE) Data Collection, Record Maintenance, and Reporting § 460.202 Participant health...
42 CFR 460.202 - Participant health outcomes data.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 42 Public Health 4 2013-10-01 2013-10-01 false Participant health outcomes data. 460.202 Section 460.202 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... FOR THE ELDERLY (PACE) Data Collection, Record Maintenance, and Reporting § 460.202 Participant health...
42 CFR 460.202 - Participant health outcomes data.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 42 Public Health 4 2012-10-01 2012-10-01 false Participant health outcomes data. 460.202 Section 460.202 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... FOR THE ELDERLY (PACE) Data Collection, Record Maintenance, and Reporting § 460.202 Participant health...
7 CFR 3560.202 - Establishing rents and utility allowances.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 15 2010-01-01 2010-01-01 false Establishing rents and utility allowances. 3560.202 Section 3560.202 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF AGRICULTURE DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS Rents § 3560.202...
17 CFR 202.8 - Small entity compliance guides.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Small entity compliance guides. 202.8 Section 202.8 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION INFORMAL AND OTHER PROCEDURES § 202.8 Small entity compliance guides. The following small entity compliance guides...
17 CFR 202.8 - Small entity compliance guides.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Small entity compliance guides. 202.8 Section 202.8 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION INFORMAL AND OTHER PROCEDURES § 202.8 Small entity compliance guides. The following small entity compliance guides...
19 CFR 202.4 - Public hearing.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 19 Customs Duties 3 2010-04-01 2010-04-01 false Public hearing. 202.4 Section 202.4 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.4 Public hearing. A public hearing will be held in connection with each full investigation...
19 CFR 202.4 - Public hearing.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 19 Customs Duties 3 2012-04-01 2012-04-01 false Public hearing. 202.4 Section 202.4 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.4 Public hearing. A public hearing will be held in connection with each full investigation...
19 CFR 202.4 - Public hearing.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 19 Customs Duties 3 2014-04-01 2014-04-01 false Public hearing. 202.4 Section 202.4 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.4 Public hearing. A public hearing will be held in connection with each full investigation...
19 CFR 202.4 - Public hearing.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 19 Customs Duties 3 2013-04-01 2013-04-01 false Public hearing. 202.4 Section 202.4 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.4 Public hearing. A public hearing will be held in connection with each full investigation...
19 CFR 202.4 - Public hearing.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 19 Customs Duties 3 2011-04-01 2011-04-01 false Public hearing. 202.4 Section 202.4 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF COSTS OF PRODUCTION § 202.4 Public hearing. A public hearing will be held in connection with each full investigation...
30 CFR 202.350 - Scope and definitions.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Scope and definitions. 202.350 Section 202.350 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE ROYALTIES Geothermal Resources § 202.350 Scope and definitions. (a) This subpart is applicable to...
49 CFR 384.202 - Test standards.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 49 Transportation 5 2011-10-01 2011-10-01 false Test standards. 384.202 Section 384.202... COMMERCIAL DRIVER'S LICENSE PROGRAM Minimum Standards for Substantial Compliance by States § 384.202 Test... driving skills test for the operation of a CMV in accordance with part 383 of this title. ...
49 CFR 199.202 - Alcohol misuse plan.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 49 Transportation 3 2011-10-01 2011-10-01 false Alcohol misuse plan. 199.202 Section 199.202... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY DRUG AND ALCOHOL TESTING Alcohol Misuse Prevention Program § 199.202 Alcohol misuse plan. Each operator must maintain and follow a written alcohol...
49 CFR 199.202 - Alcohol misuse plan.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 49 Transportation 3 2010-10-01 2010-10-01 false Alcohol misuse plan. 199.202 Section 199.202... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY DRUG AND ALCOHOL TESTING Alcohol Misuse Prevention Program § 199.202 Alcohol misuse plan. Each operator must maintain and follow a written alcohol...
48 CFR 1816.202-70 - NASA contract clause.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false NASA contract clause. 1816.202-70 Section 1816.202-70 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 1816.202-70 NASA...
48 CFR 1816.202-70 - NASA contract clause.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false NASA contract clause. 1816.202-70 Section 1816.202-70 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 1816.202-70 NASA...
48 CFR 1816.202-70 - NASA contract clause.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true NASA contract clause. 1816.202-70 Section 1816.202-70 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 1816.202-70 NASA...
48 CFR 1816.202-70 - NASA contract clause.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false NASA contract clause. 1816.202-70 Section 1816.202-70 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 1816.202-70 NASA...
48 CFR 1816.202-70 - NASA contract clause.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false NASA contract clause. 1816.202-70 Section 1816.202-70 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 1816.202-70 NASA...
48 CFR 9903.202-6 - Adequacy of Disclosure Statement.
Code of Federal Regulations, 2010 CFR
2010-10-01
... COST ACCOUNTING STANDARDS CONTRACT COVERAGE CAS Program Requirements 9903.202-6 Adequacy of Disclosure... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Adequacy of Disclosure Statement. 9903.202-6 Section 9903.202-6 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS...
20 CFR 404.202 - Other regulations related to this subpart.
Code of Federal Regulations, 2010 CFR
2010-04-01
.... 404.202 Section 404.202 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Computing Primary Insurance Amounts General § 404.202 Other... describe how you become insured for social security benefits as a result of your work in covered employment...
48 CFR 232.202-4 - Security for Government financing.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Security for Government financing. 232.202-4 Section 232.202-4 Federal Acquisition Regulations System DEFENSE ACQUISITION... Purchase Financing 232.202-4 Security for Government financing. (a)(2) When determining whether an offeror...
48 CFR 232.202-4 - Security for Government financing.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Security for Government financing. 232.202-4 Section 232.202-4 Federal Acquisition Regulations System DEFENSE ACQUISITION... Purchase Financing 232.202-4 Security for Government financing. (a)(2) When determining whether an offeror...
31 CFR 592.202 - Evasions; attempts; conspiracies.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 592.202 Section 592.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued... Prohibitions § 592.202 Evasions; attempts; conspiracies. (a) Notwithstanding the existence of any rights or...
Code of Federal Regulations, 2010 CFR
2010-10-01
... 42 Public Health 4 2010-10-01 2010-10-01 false Audits. 457.202 Section 457.202 Public Health...-Reviews and Audits; Withholding for Failure to Comply; Deferral and Disallowance of Claims; Reduction of Federal Medical Payments § 457.202 Audits. (a) Purpose. The Department's Office of Inspector General (OIG...
Code of Federal Regulations, 2010 CFR
2010-01-01
... 4 Accounts 1 2010-01-01 2010-01-01 false Description. 202.1 Section 202.1 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD OFFICIAL SEAL § 202.1 Description. (a) The official seal of the Recovery Accountability and Transparency Board (Board) is described as follows: The American Eagle, right facing, with...
40 CFR 266.202 - Definition of solid waste.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Definition of solid waste. 266.202 Section 266.202 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... MANAGEMENT FACILITIES Military Munitions § 266.202 Definition of solid waste. (a) A military munition is not...
40 CFR 266.202 - Definition of solid waste.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Definition of solid waste. 266.202 Section 266.202 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... MANAGEMENT FACILITIES Military Munitions § 266.202 Definition of solid waste. (a) A military munition is not...
Code of Federal Regulations, 2010 CFR
2010-07-01
... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Authority. 20.2 Section 20.2 Judicial Administration DEPARTMENT OF JUSTICE CRIMINAL JUSTICE INFORMATION SYSTEMS General Provisions § 20.2 Authority. These regulations are issued pursuant to sections 501 and 524(b) of the Omnibus Crime Control and Safe...
48 CFR 3006.202 - Establishing or maintaining alternative sources.
Code of Federal Regulations, 2010 CFR
2010-10-01
... COMPETITION REQUIREMENTS Full and Open Competition After Exclusion of Sources 3006.202 Establishing or maintaining alternative sources. (b)(1) The HCA is delegated authority to approve a D&F in support of a... maintaining alternative sources. 3006.202 Section 3006.202 Federal Acquisition Regulations System DEPARTMENT...
33 CFR 117.202 - Cold Spring Brook.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Cold Spring Brook. 117.202 Section 117.202 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.202 Cold Spring Brook. The draw of...
33 CFR 117.202 - Cold Spring Brook.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Cold Spring Brook. 117.202 Section 117.202 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.202 Cold Spring Brook. The draw of...
33 CFR 117.202 - Cold Spring Brook.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Cold Spring Brook. 117.202 Section 117.202 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.202 Cold Spring Brook. The draw of...
33 CFR 117.202 - Cold Spring Brook.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Cold Spring Brook. 117.202 Section 117.202 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.202 Cold Spring Brook. The draw of...
33 CFR 117.202 - Cold Spring Brook.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Cold Spring Brook. 117.202 Section 117.202 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.202 Cold Spring Brook. The draw of...
5 CFR 890.202 - Minimum standards for health benefits carriers.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 5 Administrative Personnel 2 2013-01-01 2013-01-01 false Minimum standards for health benefits carriers. 890.202 Section 890.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Health Benefits Plans § 890.202...
5 CFR 890.202 - Minimum standards for health benefits carriers.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 5 Administrative Personnel 2 2014-01-01 2014-01-01 false Minimum standards for health benefits carriers. 890.202 Section 890.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Health Benefits Plans § 890.202...
5 CFR 890.202 - Minimum standards for health benefits carriers.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Minimum standards for health benefits carriers. 890.202 Section 890.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Health Benefits Plans § 890.202...
18 CFR 706.202 - Gifts, entertainment, and favors.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Gifts, entertainment, and favors. 706.202 Section 706.202 Conservation of Power and Water Resources WATER RESOURCES COUNCIL EMPLOYEE RESPONSIBILITIES AND CONDUCT Conduct and Responsibilities of Employees § 706.202 Gifts...
18 CFR 706.202 - Gifts, entertainment, and favors.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Gifts, entertainment, and favors. 706.202 Section 706.202 Conservation of Power and Water Resources WATER RESOURCES COUNCIL EMPLOYEE RESPONSIBILITIES AND CONDUCT Conduct and Responsibilities of Employees § 706.202 Gifts...
18 CFR 706.202 - Gifts, entertainment, and favors.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Gifts, entertainment, and favors. 706.202 Section 706.202 Conservation of Power and Water Resources WATER RESOURCES COUNCIL EMPLOYEE RESPONSIBILITIES AND CONDUCT Conduct and Responsibilities of Employees § 706.202 Gifts...
18 CFR 706.202 - Gifts, entertainment, and favors.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Gifts, entertainment, and favors. 706.202 Section 706.202 Conservation of Power and Water Resources WATER RESOURCES COUNCIL EMPLOYEE RESPONSIBILITIES AND CONDUCT Conduct and Responsibilities of Employees § 706.202 Gifts...
18 CFR 706.202 - Gifts, entertainment, and favors.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Gifts, entertainment, and favors. 706.202 Section 706.202 Conservation of Power and Water Resources WATER RESOURCES COUNCIL EMPLOYEE RESPONSIBILITIES AND CONDUCT Conduct and Responsibilities of Employees § 706.202 Gifts...
37 CFR 41.202 - Suggesting an interference.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Suggesting an interference. 41.202 Section 41.202 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE PRACTICE BEFORE THE PATENT TRIAL AND APPEAL BOARD Patent Interferences § 41.202...
37 CFR 41.202 - Suggesting an interference.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Suggesting an interference. 41.202 Section 41.202 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE PRACTICE BEFORE THE PATENT TRIAL AND APPEAL BOARD Patent Interferences § 41.202...
Code of Federal Regulations, 2013 CFR
2013-04-01
... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Intervention. 70.202 Section 70.202 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... Excise and Special (Occupational) Tax Judicial Proceedings § 70.202 Intervention. If the United States is...
Code of Federal Regulations, 2012 CFR
2012-04-01
... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Intervention. 70.202 Section 70.202 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... Excise and Special (Occupational) Tax Judicial Proceedings § 70.202 Intervention. If the United States is...
Code of Federal Regulations, 2010 CFR
2010-04-01
... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Intervention. 70.202 Section 70.202 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... Excise and Special (Occupational) Tax Judicial Proceedings § 70.202 Intervention. If the United States is...
Code of Federal Regulations, 2014 CFR
2014-04-01
... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Intervention. 70.202 Section 70.202 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... Excise and Special (Occupational) Tax Judicial Proceedings § 70.202 Intervention. If the United States is...
Code of Federal Regulations, 2011 CFR
2011-04-01
... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Intervention. 70.202 Section 70.202 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... Excise and Special (Occupational) Tax Judicial Proceedings § 70.202 Intervention. If the United States is...
Code of Federal Regulations, 2010 CFR
2010-04-01
... 19 Customs Duties 3 2010-04-01 2010-04-01 false Reports. 202.6 Section 202.6 Customs Duties UNITED... PRODUCTION § 202.6 Reports. After the completion of its investigation, the Commission will incorporate its findings in a report, and the report will be transmitted to the President. ...
Code of Federal Regulations, 2013 CFR
2013-04-01
... 19 Customs Duties 3 2013-04-01 2013-04-01 false Reports. 202.6 Section 202.6 Customs Duties UNITED... PRODUCTION § 202.6 Reports. After the completion of its investigation, the Commission will incorporate its findings in a report, and the report will be transmitted to the President. ...
Code of Federal Regulations, 2014 CFR
2014-04-01
... 19 Customs Duties 3 2014-04-01 2014-04-01 false Reports. 202.6 Section 202.6 Customs Duties UNITED... PRODUCTION § 202.6 Reports. After the completion of its investigation, the Commission will incorporate its findings in a report, and the report will be transmitted to the President. ...
Code of Federal Regulations, 2011 CFR
2011-01-01
... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Coverage. 9701.202 Section 9701.202... MANAGEMENT SYSTEM Classification General § 9701.202 Coverage. (a) This subpart applies to eligible DHS... or designee under § 9701.102(b). (b) The following employees and positions are eligible for coverage...
Code of Federal Regulations, 2013 CFR
2013-01-01
... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Coverage. 351.202 Section 351.202... Provisions § 351.202 Coverage. (a) Employees covered. Except as provided in paragraph (b) of this section... administrative body to be covered hereunder. Coverage includes administrative law judges except as modified by...
Code of Federal Regulations, 2012 CFR
2012-01-01
... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Coverage. 9701.202 Section 9701.202... MANAGEMENT SYSTEM Classification General § 9701.202 Coverage. (a) This subpart applies to eligible DHS... or designee under § 9701.102(b). (b) The following employees and positions are eligible for coverage...
Code of Federal Regulations, 2014 CFR
2014-01-01
... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Coverage. 351.202 Section 351.202... Provisions § 351.202 Coverage. (a) Employees covered. Except as provided in paragraph (b) of this section... administrative body to be covered hereunder. Coverage includes administrative law judges except as modified by...
Code of Federal Regulations, 2012 CFR
2012-01-01
... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Coverage. 351.202 Section 351.202... Provisions § 351.202 Coverage. (a) Employees covered. Except as provided in paragraph (b) of this section... administrative body to be covered hereunder. Coverage includes administrative law judges except as modified by...
Code of Federal Regulations, 2014 CFR
2014-01-01
... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Coverage. 9701.202 Section 9701.202... MANAGEMENT SYSTEM Classification General § 9701.202 Coverage. (a) This subpart applies to eligible DHS... or designee under § 9701.102(b). (b) The following employees and positions are eligible for coverage...
Code of Federal Regulations, 2013 CFR
2013-01-01
... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Coverage. 9701.202 Section 9701.202... MANAGEMENT SYSTEM Classification General § 9701.202 Coverage. (a) This subpart applies to eligible DHS... or designee under § 9701.102(b). (b) The following employees and positions are eligible for coverage...
7 CFR 1260.202 - Books and records.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 7 Agriculture 10 2012-01-01 2012-01-01 false Books and records. 1260.202 Section 1260.202 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Promotion and Research Order Reports, Books and Records § 1260.202 Books and records. Each person subject to...
7 CFR 1260.202 - Books and records.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 7 Agriculture 10 2011-01-01 2011-01-01 false Books and records. 1260.202 Section 1260.202 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Promotion and Research Order Reports, Books and Records § 1260.202 Books and records. Each person subject to...
7 CFR 1260.202 - Books and records.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 7 Agriculture 10 2013-01-01 2013-01-01 false Books and records. 1260.202 Section 1260.202 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Promotion and Research Order Reports, Books and Records § 1260.202 Books and records. Each person subject to...
7 CFR 1260.202 - Books and records.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 10 2014-01-01 2014-01-01 false Books and records. 1260.202 Section 1260.202 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Promotion and Research Order Reports, Books and Records § 1260.202 Books and records. Each person subject to...
30 CFR 202.350 - Scope and definitions.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Scope and definitions. 202.350 Section 202.350 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT ROYALTIES Geothermal Resources § 202.350 Scope and definitions. (a) This subpart is applicable to all...
48 CFR 13.202 - Purchase guidelines.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Purchase guidelines. 13.202 Section 13.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SIMPLIFIED ACQUISITION PROCEDURES Actions at or Below the Micro-Purchase Threshold 13.202 Purchase guidelines. (a)...
Pizzimenti, Stefania; Ferracin, Manuela; Sabbioni, Silvia; Toaldo, Cristina; Pettazzoni, Piergiorgio; Dianzani, Mario Umberto; Negrini, Massimo; Barrera, Giuseppina
2009-01-15
4-Hydroxynonenal (HNE) is one of several lipid oxidation products that may have an impact on human pathophysiology. It is an important second messenger involved in the regulation of various cellular processes and exhibits antiproliferative and differentiative properties in various tumor cell lines. The mechanisms by which HNE affects cell growth and differentiation are only partially clarified. Because microRNAs (miRNAs) have the ability to regulate several cellular processes, we hypothesized that HNE, in addition to other mechanisms, could affect miRNA expression. Here, we present the results of a genome-wide miRNA expression profiling of HNE-treated HL-60 leukemic cells. Among 470 human miRNAs, 10 were found to be differentially expressed between control and HNE-treated cells (at p<0.05). Six miRNAs were down-regulated (miR-181a*, miR-199b, miR-202, miR-378, miR-454-3p, miR-575) and 4 were up-regulated (miR-125a, miR-339, miR-663, miR-660). Three of these regulated miRNAs (miR-202, miR-339, miR-378) were further assayed and validated by quantitative real-time RT-PCR. Moreover, consistent with the down-regulation of miR-378, HNE also induced the expression of the SUFU protein, a tumor suppressor recently identified as a target of miR-378. The finding that HNE could regulate the expression of miRNAs and their targets opens new perspectives on the understanding of HNE-controlled pathways. A functional analysis of 191 putative gene targets of miRNAs modulated by HNE is discussed.
Mapping of Crowdsourcing in Health: Systematic Review
Mansouri, Ghizlène; Benchoufi, Mehdi; Vivot, Alexandre; Ravaud, Philippe
2018-01-01
Background Crowdsourcing involves obtaining ideas, needed services, or content by soliciting Web-based contributions from a crowd. The 4 types of crowdsourced tasks (problem solving, data processing, surveillance or monitoring, and surveying) can be applied in the 3 categories of health (promotion, research, and care). Objective This study aimed to map the different applications of crowdsourcing in health to assess the fields of health that are using crowdsourcing and the crowdsourced tasks used. We also describe the logistics of crowdsourcing and the characteristics of crowd workers. Methods MEDLINE, EMBASE, and ClinicalTrials.gov were searched for available reports from inception to March 30, 2016, with no restriction on language or publication status. Results We identified 202 relevant studies that used crowdsourcing, including 9 randomized controlled trials, of which only one had posted results at ClinicalTrials.gov. Crowdsourcing was used in health promotion (91/202, 45.0%), research (73/202, 36.1%), and care (38/202, 18.8%). The 4 most frequent areas of application were public health (67/202, 33.2%), psychiatry (32/202, 15.8%), surgery (22/202, 10.9%), and oncology (14/202, 6.9%). Half of the reports (99/202, 49.0%) referred to data processing, 34.6% (70/202) referred to surveying, 10.4% (21/202) referred to surveillance or monitoring, and 5.9% (12/202) referred to problem-solving. Labor market platforms (eg, Amazon Mechanical Turk) were used in most studies (190/202, 94%). The crowd workers’ characteristics were poorly reported, and crowdsourcing logistics were missing from two-thirds of the reports. When reported, the median size of the crowd was 424 (first and third quartiles: 167-802); crowd workers’ median age was 34 years (32-36). Crowd workers were mainly recruited nationally, particularly in the United States. For many studies (58.9%, 119/202), previous experience in crowdsourcing was required, and passing a qualification test or training was seldom needed (11.9% of studies; 24/202). For half of the studies, monetary incentives were mentioned, with mainly less than US $1 to perform the task. The time needed to perform the task was mostly less than 10 min (58.9% of studies; 119/202). Data quality validation was used in 54/202 studies (26.7%), mainly by attention check questions or by replicating the task with several crowd workers. Conclusions The use of crowdsourcing, which allows access to a large pool of participants as well as saving time in data collection, lowering costs, and speeding up innovations, is increasing in health promotion, research, and care. However, the description of crowdsourcing logistics and crowd workers’ characteristics is frequently missing in study reports and needs to be precisely reported to better interpret the study findings and replicate them. PMID:29764795
Baptista-Salazar, Carluvy; Hintelmann, Holger; Biester, Harald
2018-04-25
Mercury (Hg) released by mining activities can be dispersed in the environment, where it is subject to species transformations. Hg isotope ratios have been used to track sources in Hg contaminated areas, although it is unclear to what extent variations in δ-values are attributed to distinct Hg species. Hg was mined as Hg sulphide (cinnabar) in Idrija, Slovenia for centuries. Sediments are loaded with mining-residues (cinnabar and calcine), whereas contaminated soils mainly contain Hg bound to natural organic matter (NOM-Hg) related to atmospheric Hg deposition. Hg released from soils and sediments is transported as suspended matter (SM) in the Idrijca river to the Gulf of Trieste (GT), Italy. We determine Hg isotope ratios in river SM, sediments and soils from the Idrijca-catchment to decipher the Hg isotope ratio variability related to Hg species distribution in different grain-size fractions. δ202Hg values of SM collected from tributaries corresponded to those found in soils ranging from -2.58 to 0.19‰ and from -2.27 to -0.88‰, respectively. Speciation measurements reveal that fine fractions (0.45-20 μm) are dominated by NOM-Hg, while larger fractions contain more cinnabar. More negative δ202Hg values were related to higher proportions of NOM-Hg, which are predominant in soils and SM. Rain events increase SM-loads in the river, mainly due to resuspension of coarse grain-size fractions of bottom sediments bearing larger proportions of cinnabar, which leads to more positive δ202Hg values. The large magnitude of variation in δ202Hg and the smaller magnitude of variation in Δ199Hg (-0.37 to 0.09‰) are likely related to fractionation during ore roasting. Soil samples with high NOM-Hg content show more negative δ202Hg values and larger variation of Δ199Hg. More negative δ202Hg values in GT sediments were rather linked to distant sedimentation of soil derived NOM-Hg than to sedimentation of autochthonous marine material. Heterogeneity in the Idrija ore and ore processing likely produce large variations in the Hg isotopic composition of cinnabar and released metallic Hg, which complicate the differentiation of Hg sources. Combining Hg isotope measurements with solid phase Hg speciation reveals that Hg isotope ratios rather indicate different Hg species and are not necessarily symptomatic for Hg pollution sources.
48 CFR 3452.202-1 - Definitions-Department of Education.
Code of Federal Regulations, 2011 CFR
2011-10-01
... Education. 3452.202-1 Section 3452.202-1 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION... Clauses 3452.202-1 Definitions—Department of Education. As prescribed in 3402.201, insert the following...—Department of Education (MAR 2011) (a) The definitions at FAR 2.101 are appended with those contained in...
31 CFR 598.202 - Blocking of assets.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Blocking of assets. 598.202 Section 598.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... Prohibitions § 598.202 Blocking of assets. Except to the extent provided in regulations, orders, instructions...
31 CFR 598.202 - Blocking of assets.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Blocking of assets. 598.202 Section 598.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... Prohibitions § 598.202 Blocking of assets. Except to the extent provided in regulations, orders, instructions...
31 CFR 598.202 - Blocking of assets.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Blocking of assets. 598.202 Section 598.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... Prohibitions § 598.202 Blocking of assets. Except to the extent provided in regulations, orders, instructions...
31 CFR 598.202 - Blocking of assets.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Blocking of assets. 598.202 Section 598.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... Prohibitions § 598.202 Blocking of assets. Except to the extent provided in regulations, orders, instructions...
31 CFR 598.202 - Blocking of assets.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Blocking of assets. 598.202 Section 598.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... Prohibitions § 598.202 Blocking of assets. Except to the extent provided in regulations, orders, instructions...
15 CFR 280.202 - Penalties, remedies, and sanctions.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Penalties, remedies, and sanctions. 280.202 Section 280.202 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... PROGRAMS FASTENER QUALITY Enforcement § 280.202 Penalties, remedies, and sanctions. (a) Civil remedies. The...
4 CFR 202.3 - Prohibitions against misuse of seal.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 4 Accounts 1 2010-01-01 2010-01-01 false Prohibitions against misuse of seal. 202.3 Section 202.3 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD OFFICIAL SEAL § 202.3 Prohibitions against misuse of seal. (a) Falsely making, forging, counterfeiting, mutilating, or altering the Board seal or...
4 CFR 202.2 - Authority to affix seal.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 4 Accounts 1 2010-01-01 2010-01-01 false Authority to affix seal. 202.2 Section 202.2 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD OFFICIAL SEAL § 202.2 Authority to affix seal. (a) The following officials of the Board are authorized to affix the official seal (including reproductions) to...
4 CFR 202.2 - Authority to affix seal.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 4 Accounts 1 2011-01-01 2011-01-01 false Authority to affix seal. 202.2 Section 202.2 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD OFFICIAL SEAL § 202.2 Authority to affix seal. (a) The following officials of the Board are authorized to affix the official seal (including reproductions) to...
4 CFR 202.3 - Prohibitions against misuse of seal.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 4 Accounts 1 2011-01-01 2011-01-01 false Prohibitions against misuse of seal. 202.3 Section 202.3 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD OFFICIAL SEAL § 202.3 Prohibitions against misuse of seal. (a) Falsely making, forging, counterfeiting, mutilating, or altering the Board seal or...
Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-11
... Childers, U.S. EPA at 202-564-1082 or 202- 564-1352 (Fax), mailing address: Office of Air and Radiation.../index.html or by contacting Mr. Pat Childers, U.S. EPA at 202-564-1082 or 202-564-1352 (Fax), mailing...
Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-21
... 202-564-1082 or 202- 564-1352 (Fax), mailing address: Office of Air and Radiation (6102A), 1200.../caaac by clicking on Awards Program or by contacting Mr. Pat Childers, U.S. EPA at 202-564-1082 or 202...
37 CFR 202.22 - Acquisition and deposit of unpublished audio and audiovisual transmission programs.
Code of Federal Regulations, 2011 CFR
2011-07-01
... unpublished audio and audiovisual transmission programs. 202.22 Section 202.22 Patents, Trademarks, and... REGISTRATION OF CLAIMS TO COPYRIGHT § 202.22 Acquisition and deposit of unpublished audio and audiovisual... and copies of unpublished audio and audiovisual transmission programs by the Library of Congress under...
37 CFR 202.22 - Acquisition and deposit of unpublished audio and audiovisual transmission programs.
Code of Federal Regulations, 2012 CFR
2012-07-01
... unpublished audio and audiovisual transmission programs. 202.22 Section 202.22 Patents, Trademarks, and... REGISTRATION OF CLAIMS TO COPYRIGHT § 202.22 Acquisition and deposit of unpublished audio and audiovisual... and copies of unpublished audio and audiovisual transmission programs by the Library of Congress under...
37 CFR 202.22 - Acquisition and deposit of unpublished audio and audiovisual transmission programs.
Code of Federal Regulations, 2013 CFR
2013-07-01
... unpublished audio and audiovisual transmission programs. 202.22 Section 202.22 Patents, Trademarks, and... REGISTRATION OF CLAIMS TO COPYRIGHT § 202.22 Acquisition and deposit of unpublished audio and audiovisual... and copies of unpublished audio and audiovisual transmission programs by the Library of Congress under...
37 CFR 202.22 - Acquisition and deposit of unpublished audio and audiovisual transmission programs.
Code of Federal Regulations, 2014 CFR
2014-07-01
... unpublished audio and audiovisual transmission programs. 202.22 Section 202.22 Patents, Trademarks, and... REGISTRATION OF CLAIMS TO COPYRIGHT § 202.22 Acquisition and deposit of unpublished audio and audiovisual... and copies of unpublished audio and audiovisual transmission programs by the Library of Congress under...
32 CFR 202.11 - Documenting RAB activities.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 32 National Defense 2 2010-07-01 2010-07-01 false Documenting RAB activities. 202.11 Section 202.11 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS RESTORATION ADVISORY BOARDS Operating Requirements § 202.11 Documenting RAB activities. (a) The installation shall document information...
Code of Federal Regulations, 2010 CFR
2010-07-01
... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Royalties. 202.52 Section 202.52 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT ROYALTIES Oil, Gas, and OCS Sulfur, General § 202.52 Royalties. (a) Royalties on oil, gas, and OCS sulfur shall be at...
32 CFR 202.8 - Training RAB members.
Code of Federal Regulations, 2010 CFR
2010-07-01
... provide in-house assistance to discuss technical issues. Funding for training activities must be within... 32 National Defense 2 2010-07-01 2010-07-01 false Training RAB members. 202.8 Section 202.8...) MISCELLANEOUS RESTORATION ADVISORY BOARDS Operating Requirements § 202.8 Training RAB members. Training is not...
20 CFR 655.202 - Contents of job offers.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Contents of job offers. 655.202 Section 655.202 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR TEMPORARY...-H-2A Agricultural Employment § 655.202 Contents of job offers. (a) So that the employment of aliens...
Code of Federal Regulations, 2010 CFR
2010-10-01
... 42 Public Health 1 2010-10-01 2010-10-01 false Application. 56.202 Section 56.202 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR MIGRANT HEALTH SERVICES Grants for Planning and Developing Migrant Health Centers § 56.202 Application. To be approved by the...
29 CFR 1650.202 - Past-due legally enforceable debt.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 29 Labor 4 2010-07-01 2010-07-01 false Past-due legally enforceable debt. 1650.202 Section 1650.202 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION DEBT COLLECTION Procedures for the Collection of Debts by Federal Tax Refund Offset § 1650.202 Past-due legally...
50 CFR 223.202 - Steller sea lion.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Steller sea lion. 223.202 Section 223.202... Threatened Marine and Anadromous Species § 223.202 Steller sea lion. (a) General prohibitions. The... the eastern population of Steller sea lions: (1) No discharge of firearms. Except as provided in...
50 CFR 223.202 - Steller sea lion.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 50 Wildlife and Fisheries 10 2013-10-01 2013-10-01 false Steller sea lion. 223.202 Section 223.202... Threatened Marine and Anadromous Species § 223.202 Steller sea lion. (a) General prohibitions. The... the eastern population of Steller sea lions: (1) No discharge of firearms. Except as provided in...
50 CFR 223.202 - Steller sea lion.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Steller sea lion. 223.202 Section 223.202... Threatened Marine and Anadromous Species § 223.202 Steller sea lion. (a) General prohibitions. The... the eastern population of Steller sea lions: (1) No discharge of firearms. Except as provided in...
50 CFR 223.202 - Steller sea lion.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 50 Wildlife and Fisheries 10 2012-10-01 2012-10-01 false Steller sea lion. 223.202 Section 223.202... Threatened Marine and Anadromous Species § 223.202 Steller sea lion. (a) General prohibitions. The... the eastern population of Steller sea lions: (1) No discharge of firearms. Except as provided in...
24 CFR 100.202 - General prohibitions against discrimination because of handicap.
Code of Federal Regulations, 2012 CFR
2012-04-01
... discrimination because of handicap. 100.202 Section 100.202 Housing and Urban Development Regulations Relating to... Against Discrimination Because of Handicap § 100.202 General prohibitions against discrimination because of handicap. (a) It shall be unlawful to discriminate in the sale or rental, or to otherwise make...
24 CFR 100.202 - General prohibitions against discrimination because of handicap.
Code of Federal Regulations, 2010 CFR
2010-04-01
... discrimination because of handicap. 100.202 Section 100.202 Housing and Urban Development Regulations Relating to... Against Discrimination Because of Handicap § 100.202 General prohibitions against discrimination because of handicap. (a) It shall be unlawful to discriminate in the sale or rental, or to otherwise make...
24 CFR 100.202 - General prohibitions against discrimination because of handicap.
Code of Federal Regulations, 2013 CFR
2013-04-01
... discrimination because of handicap. 100.202 Section 100.202 Housing and Urban Development Regulations Relating to... Against Discrimination Because of Handicap § 100.202 General prohibitions against discrimination because of handicap. (a) It shall be unlawful to discriminate in the sale or rental, or to otherwise make...
24 CFR 100.202 - General prohibitions against discrimination because of handicap.
Code of Federal Regulations, 2011 CFR
2011-04-01
... discrimination because of handicap. 100.202 Section 100.202 Housing and Urban Development Regulations Relating to... Against Discrimination Because of Handicap § 100.202 General prohibitions against discrimination because of handicap. (a) It shall be unlawful to discriminate in the sale or rental, or to otherwise make...
24 CFR 100.202 - General prohibitions against discrimination because of handicap.
Code of Federal Regulations, 2014 CFR
2014-04-01
... discrimination because of handicap. 100.202 Section 100.202 Housing and Urban Development Regulations Relating to... Against Discrimination Because of Handicap § 100.202 General prohibitions against discrimination because of handicap. (a) It shall be unlawful to discriminate in the sale or rental, or to otherwise make...
Code of Federal Regulations, 2010 CFR
2010-07-01
... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Powers. 20.202 Section 20.202... § 20.202 Powers. The ALJ shall have all powers necessary to the conduct of fair, fast, and impartial hearings, including the powers to— (a) Administer oaths and affirmations; (b) Issue subpoenas authorized by...
5 CFR 591.202 - Why does the Government pay COLAs?
Code of Federal Regulations, 2012 CFR
2012-01-01
... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Why does the Government pay COLAs? 591.202 Section 591.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS... Allowances and Post Differentials § 591.202 Why does the Government pay COLAs? The Government pays COLAs as...
5 CFR 591.202 - Why does the Government pay COLAs?
Code of Federal Regulations, 2014 CFR
2014-01-01
... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Why does the Government pay COLAs? 591.202 Section 591.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS... Allowances and Post Differentials § 591.202 Why does the Government pay COLAs? The Government pays COLAs as...
5 CFR 591.202 - Why does the Government pay COLAs?
Code of Federal Regulations, 2011 CFR
2011-01-01
... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Why does the Government pay COLAs? 591.202 Section 591.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS... Allowances and Post Differentials § 591.202 Why does the Government pay COLAs? The Government pays COLAs as...
5 CFR 591.202 - Why does the Government pay COLAs?
Code of Federal Regulations, 2013 CFR
2013-01-01
... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Why does the Government pay COLAs? 591.202 Section 591.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS... Allowances and Post Differentials § 591.202 Why does the Government pay COLAs? The Government pays COLAs as...
5 CFR 591.202 - Why does the Government pay COLAs?
Code of Federal Regulations, 2010 CFR
2010-01-01
... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Why does the Government pay COLAs? 591.202 Section 591.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS... Allowances and Post Differentials § 591.202 Why does the Government pay COLAs? The Government pays COLAs as...
7 CFR 1738.202 - Elements of a complete application.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 11 2014-01-01 2014-01-01 false Elements of a complete application. 1738.202 Section 1738.202 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE... Underwriting § 1738.202 Elements of a complete application. An applicant must submit to the Agency a complete...
7 CFR 1738.202 - Elements of a complete application.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 7 Agriculture 11 2013-01-01 2013-01-01 false Elements of a complete application. 1738.202 Section 1738.202 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE... Underwriting § 1738.202 Elements of a complete application. An applicant must submit to the Agency a complete...
7 CFR 1738.202 - Elements of a complete application.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 7 Agriculture 11 2012-01-01 2012-01-01 false Elements of a complete application. 1738.202 Section 1738.202 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE... Underwriting § 1738.202 Elements of a complete application. An applicant must submit to the Agency a complete...
10 CFR 1707.202 - Factors DNFSB will consider.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 10 Energy 4 2012-01-01 2012-01-01 false Factors DNFSB will consider. 1707.202 Section 1707.202 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD TESTIMONY BY DNFSB EMPLOYEES AND PRODUCTION OF OFFICIAL RECORDS IN LEGAL PROCEEDINGS Requests for Testimony and Production of Documents § 1707.202 Factors DNFSB...
10 CFR 1707.202 - Factors DNFSB will consider.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 10 Energy 4 2011-01-01 2011-01-01 false Factors DNFSB will consider. 1707.202 Section 1707.202 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD TESTIMONY BY DNFSB EMPLOYEES AND PRODUCTION OF OFFICIAL RECORDS IN LEGAL PROCEEDINGS Requests for Testimony and Production of Documents § 1707.202 Factors DNFSB...
10 CFR 1707.202 - Factors DNFSB will consider.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 10 Energy 4 2014-01-01 2014-01-01 false Factors DNFSB will consider. 1707.202 Section 1707.202 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD TESTIMONY BY DNFSB EMPLOYEES AND PRODUCTION OF OFFICIAL RECORDS IN LEGAL PROCEEDINGS Requests for Testimony and Production of Documents § 1707.202 Factors DNFSB...
10 CFR 1707.202 - Factors DNFSB will consider.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 10 Energy 4 2010-01-01 2010-01-01 false Factors DNFSB will consider. 1707.202 Section 1707.202 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD TESTIMONY BY DNFSB EMPLOYEES AND PRODUCTION OF OFFICIAL RECORDS IN LEGAL PROCEEDINGS Requests for Testimony and Production of Documents § 1707.202 Factors DNFSB...
10 CFR 1707.202 - Factors DNFSB will consider.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 10 Energy 4 2013-01-01 2013-01-01 false Factors DNFSB will consider. 1707.202 Section 1707.202 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD TESTIMONY BY DNFSB EMPLOYEES AND PRODUCTION OF OFFICIAL RECORDS IN LEGAL PROCEEDINGS Requests for Testimony and Production of Documents § 1707.202 Factors DNFSB...
48 CFR 3452.202-1 - Definitions-Department of Education.
Code of Federal Regulations, 2014 CFR
2014-10-01
... Education. 3452.202-1 Section 3452.202-1 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION... Clauses 3452.202-1 Definitions—Department of Education. As prescribed in 3402.201, insert the following...—Department of Education (MAR 2011) (a) The definitions at FAR 2.101 are appended with those contained in...
48 CFR 3452.202-1 - Definitions-Department of Education.
Code of Federal Regulations, 2012 CFR
2012-10-01
... Education. 3452.202-1 Section 3452.202-1 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION... Clauses 3452.202-1 Definitions—Department of Education. As prescribed in 3402.201, insert the following...—Department of Education (MAR 2011) (a) The definitions at FAR 2.101 are appended with those contained in...
48 CFR 3452.202-1 - Definitions-Department of Education.
Code of Federal Regulations, 2013 CFR
2013-10-01
... Education. 3452.202-1 Section 3452.202-1 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION... Clauses 3452.202-1 Definitions—Department of Education. As prescribed in 3402.201, insert the following...—Department of Education (MAR 2011) (a) The definitions at FAR 2.101 are appended with those contained in...
5 CFR 892.202 - Are retirees eligible for the premium conversion plan?
Code of Federal Regulations, 2010 CFR
2010-01-01
... conversion plan? 892.202 Section 892.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL FLEXIBLE BENEFITS PLAN: PRE-TAX PAYMENT OF HEALTH BENEFITS PREMIUMS Eligibility and Participation § 892.202 Are retirees eligible for the premium conversion plan? No...
5 CFR 582.202 - Service of legal process.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Service of legal process. 582.202 Section 582.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS COMMERCIAL GARNISHMENT OF FEDERAL EMPLOYEES' PAY Service of Legal Process § 582.202 Service of legal process. (a) A...
5 CFR 582.202 - Service of legal process.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Service of legal process. 582.202 Section 582.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS COMMERCIAL GARNISHMENT OF FEDERAL EMPLOYEES' PAY Service of Legal Process § 582.202 Service of legal process. (a) A...
40 CFR 246.202-3 - Recommended procedures: Market study.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Recommended procedures: Market study. 246.202-3 Section 246.202-3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... § 246.202-3 Recommended procedures: Market study. An investigation of markets should be made by the...
40 CFR 246.202-3 - Recommended procedures: Market study.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recommended procedures: Market study. 246.202-3 Section 246.202-3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... § 246.202-3 Recommended procedures: Market study. An investigation of markets should be made by the...
31 CFR 537.202 - Prohibited exportation or reexportation of financial services to Burma.
Code of Federal Regulations, 2010 CFR
2010-07-01
... reexportation of financial services to Burma. 537.202 Section 537.202 Money and Finance: Treasury Regulations... permit granted prior to July 29, 2003, the exportation or reexportation of financial services to Burma... BURMESE SANCTIONS REGULATIONS Prohibitions § 537.202 Prohibited exportation or reexportation of financial...
5 CFR 315.202 - Conversion from career-conditional to career tenure.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Conversion from career-conditional to career tenure. 315.202 Section 315.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL... § 315.202 Conversion from career-conditional to career tenure. A career-conditional employee becomes a...
20 CFR 202.13 - Electric railways.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Electric railways. 202.13 Section 202.13... THE ACT § 202.13 Electric railways. (a) The Deputy General Counsel will require the submission of information pertaining to the history and operations of an electric railway with a view to determining whether...
20 CFR 202.13 - Electric railways.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Electric railways. 202.13 Section 202.13... THE ACT § 202.13 Electric railways. (a) The Deputy General Counsel will require the submission of information pertaining to the history and operations of an electric railway with a view to determining whether...
20 CFR 202.13 - Electric railways.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Electric railways. 202.13 Section 202.13... THE ACT § 202.13 Electric railways. (a) The Deputy General Counsel will require the submission of information pertaining to the history and operations of an electric railway with a view to determining whether...
20 CFR 202.13 - Electric railways.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Electric railways. 202.13 Section 202.13... THE ACT § 202.13 Electric railways. (a) The Deputy General Counsel will require the submission of information pertaining to the history and operations of an electric railway with a view to determining whether...
Code of Federal Regulations, 2011 CFR
2011-07-01
... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Powers. 20.202 Section 20.202... § 20.202 Powers. The ALJ shall have all powers necessary to the conduct of fair, fast, and impartial hearings, including the powers to— (a) Administer oaths and affirmations; (b) Issue subpoenas authorized by...
48 CFR 1832.202-1 - Policy. (NASA supplements paragraph (b))
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Policy. (NASA supplements paragraph (b)) 1832.202-1 Section 1832.202-1 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND... Financing 1832.202-1 Policy. (NASA supplements paragraph (b)) (b)(6) Advance payment limitations do not...
48 CFR 1832.202-1 - Policy. (NASA supplements paragraph (b))
Code of Federal Regulations, 2013 CFR
2013-10-01
... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Policy. (NASA supplements paragraph (b)) 1832.202-1 Section 1832.202-1 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND... Financing 1832.202-1 Policy. (NASA supplements paragraph (b)) (b)(6) Advance payment limitations do not...
48 CFR 1832.202-1 - Policy. (NASA supplements paragraph (b))
Code of Federal Regulations, 2014 CFR
2014-10-01
... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Policy. (NASA supplements paragraph (b)) 1832.202-1 Section 1832.202-1 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND... Financing 1832.202-1 Policy. (NASA supplements paragraph (b)) (b)(6) Advance payment limitations do not...
48 CFR 1832.202-1 - Policy. (NASA supplements paragraph (b))
Code of Federal Regulations, 2012 CFR
2012-10-01
... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Policy. (NASA supplements paragraph (b)) 1832.202-1 Section 1832.202-1 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND... Financing 1832.202-1 Policy. (NASA supplements paragraph (b)) (b)(6) Advance payment limitations do not...
48 CFR 1832.202-1 - Policy. (NASA supplements paragraph (b))
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Policy. (NASA supplements paragraph (b)) 1832.202-1 Section 1832.202-1 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND... Financing 1832.202-1 Policy. (NASA supplements paragraph (b)) (b)(6) Advance payment limitations do not...
41 CFR 301-51.202 - When must I account for my advance?
Code of Federal Regulations, 2014 CFR
2014-07-01
... my advance? 301-51.202 Section 301-51.202 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ARRANGING FOR TRAVEL SERVICES, PAYING TRAVEL EXPENSES, AND CLAIMING REIMBURSEMENT 51-PAYING TRAVEL EXPENSES Receiving Travel Advances § 301-51.202 When...
41 CFR 301-51.202 - When must I account for my advance?
Code of Federal Regulations, 2012 CFR
2012-07-01
... my advance? 301-51.202 Section 301-51.202 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ARRANGING FOR TRAVEL SERVICES, PAYING TRAVEL EXPENSES, AND CLAIMING REIMBURSEMENT 51-PAYING TRAVEL EXPENSES Receiving Travel Advances § 301-51.202 When...
41 CFR 301-51.202 - When must I account for my advance?
Code of Federal Regulations, 2011 CFR
2011-07-01
... my advance? 301-51.202 Section 301-51.202 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ARRANGING FOR TRAVEL SERVICES, PAYING TRAVEL EXPENSES, AND CLAIMING REIMBURSEMENT 51-PAYING TRAVEL EXPENSES Receiving Travel Advances § 301-51.202 When...
41 CFR 301-51.202 - When must I account for my advance?
Code of Federal Regulations, 2010 CFR
2010-07-01
... my advance? 301-51.202 Section 301-51.202 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ARRANGING FOR TRAVEL SERVICES, PAYING TRAVEL EXPENSES, AND CLAIMING REIMBURSEMENT 51-PAYING TRAVEL EXPENSES Receiving Travel Advances § 301-51.202 When...
41 CFR 301-51.202 - When must I account for my advance?
Code of Federal Regulations, 2013 CFR
2013-07-01
... my advance? 301-51.202 Section 301-51.202 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ARRANGING FOR TRAVEL SERVICES, PAYING TRAVEL EXPENSES, AND CLAIMING REIMBURSEMENT 51-PAYING TRAVEL EXPENSES Receiving Travel Advances § 301-51.202 When...
26 CFR 601.202 - Closing agreements.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 26 Internal Revenue 20 2011-04-01 2011-04-01 false Closing agreements. 601.202 Section 601.202... STATEMENT OF PROCEDURAL RULES Rulings and Other Specific Matters § 601.202 Closing agreements. (a) General..., may enter into and approve a written agreement with a person relating to the liability of such person...
7 CFR 956.202 - Assessment rate.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 7 Agriculture 8 2011-01-01 2011-01-01 false Assessment rate. 956.202 Section 956.202 Agriculture... VALLEY OF SOUTHEAST WASHINGTON AND NORTHEAST OREGON Rules and Regulations § 956.202 Assessment rate. On and after January 1, 2008, an assessment rate of $0.22 per 50-pound bag or equivalent is established...
7 CFR 956.202 - Assessment rate.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 7 Agriculture 8 2012-01-01 2012-01-01 false Assessment rate. 956.202 Section 956.202 Agriculture... VALLEY OF SOUTHEAST WASHINGTON AND NORTHEAST OREGON Rules and Regulations § 956.202 Assessment rate. On and after January 1, 2008, an assessment rate of $0.22 per 50-pound bag or equivalent is established...
7 CFR 956.202 - Assessment rate.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 8 2010-01-01 2010-01-01 false Assessment rate. 956.202 Section 956.202 Agriculture... VALLEY OF SOUTHEAST WASHINGTON AND NORTHEAST OREGON Rules and Regulations § 956.202 Assessment rate. On and after January 1, 2008, an assessment rate of $0.22 per 50-pound bag or equivalent is established...
7 CFR 956.202 - Assessment rate.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 7 Agriculture 8 2013-01-01 2013-01-01 false Assessment rate. 956.202 Section 956.202 Agriculture... VALLEY OF SOUTHEAST WASHINGTON AND NORTHEAST OREGON Rules and Regulations § 956.202 Assessment rate. On and after January 1, 2008, an assessment rate of $0.22 per 50-pound bag or equivalent is established...
Code of Federal Regulations, 2012 CFR
2012-10-01
... 42 Public Health 1 2012-10-01 2012-10-01 false Definitions. 59.202 Section 59.202 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR FAMILY PLANNING SERVICES Grants for Family Planning Service Training § 59.202 Definitions. As used in this subpart: (a) Act means...
Code of Federal Regulations, 2013 CFR
2013-10-01
... 42 Public Health 1 2013-10-01 2013-10-01 false Definitions. 59.202 Section 59.202 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR FAMILY PLANNING SERVICES Grants for Family Planning Service Training § 59.202 Definitions. As used in this subpart: (a) Act means...
Code of Federal Regulations, 2011 CFR
2011-10-01
... 42 Public Health 1 2011-10-01 2011-10-01 false Definitions. 59.202 Section 59.202 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR FAMILY PLANNING SERVICES Grants for Family Planning Service Training § 59.202 Definitions. As used in this subpart: (a) Act means...
Code of Federal Regulations, 2010 CFR
2010-10-01
... 42 Public Health 1 2010-10-01 2010-10-01 false Definitions. 59.202 Section 59.202 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR FAMILY PLANNING SERVICES Grants for Family Planning Service Training § 59.202 Definitions. As used in this subpart: (a) Act means...
Code of Federal Regulations, 2014 CFR
2014-10-01
... 42 Public Health 1 2014-10-01 2014-10-01 false Definitions. 59.202 Section 59.202 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR FAMILY PLANNING SERVICES Grants for Family Planning Service Training § 59.202 Definitions. As used in this subpart: (a) Act means...
7 CFR 956.202 - Assessment rate.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 8 2014-01-01 2014-01-01 false Assessment rate. 956.202 Section 956.202 Agriculture... VALLEY OF SOUTHEAST WASHINGTON AND NORTHEAST OREGON Rules and Regulations § 956.202 Assessment rate. On and after January 1, 2008, an assessment rate of $0.22 per 50-pound bag or equivalent is established...
41 CFR 109-38.202-50 - Security.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Security. 109-38.202-50 Section 109-38.202-50 Public Contracts and Property Management Federal Property Management Regulations....202-50 Security. Unissued license tags shall be stored in a locked drawer, cabinet, or storage area...
41 CFR 109-38.202-50 - Security.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Security. 109-38.202-50 Section 109-38.202-50 Public Contracts and Property Management Federal Property Management Regulations....202-50 Security. Unissued license tags shall be stored in a locked drawer, cabinet, or storage area...
41 CFR 109-38.202-50 - Security.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Security. 109-38.202-50 Section 109-38.202-50 Public Contracts and Property Management Federal Property Management Regulations....202-50 Security. Unissued license tags shall be stored in a locked drawer, cabinet, or storage area...
41 CFR 109-38.202-50 - Security.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Security. 109-38.202-50 Section 109-38.202-50 Public Contracts and Property Management Federal Property Management Regulations....202-50 Security. Unissued license tags shall be stored in a locked drawer, cabinet, or storage area...
49 CFR 1016.202 - Net worth exhibit.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 49 Transportation 8 2011-10-01 2011-10-01 false Net worth exhibit. 1016.202 Section 1016.202... BY PARTIES TO BOARD ADJUDICATORY PROCEEDINGS Information Required From Applicants § 1016.202 Net... worth of the applicant and any affiliates (as defined in § 1016.105(f) of this part) when the proceeding...
49 CFR 1016.202 - Net worth exhibit.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 49 Transportation 8 2010-10-01 2010-10-01 false Net worth exhibit. 1016.202 Section 1016.202... BY PARTIES TO BOARD ADJUDICATORY PROCEEDINGS Information Required From Applicants § 1016.202 Net... worth of the applicant and any affiliates (as defined in § 1016.105(f) of this part) when the proceeding...
17 CFR 202.9 - Small entity enforcement penalty reduction policy.
Code of Federal Regulations, 2010 CFR
2010-04-01
... penalty reduction policy. 202.9 Section 202.9 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION INFORMAL AND OTHER PROCEDURES § 202.9 Small entity enforcement penalty reduction policy. The Commission's policy with respect to whether to reduce or assess civil money penalties against a small entity...
7 CFR 330.202 - Consideration of applications for permits to move plant pests.
Code of Federal Regulations, 2010 CFR
2010-01-01
... plant pests. 330.202 Section 330.202 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FEDERAL PLANT PEST REGULATIONS; GENERAL; PLANT PESTS; SOIL, STONE, AND QUARRY PRODUCTS; GARBAGE Movement of Plant Pests § 330.202...
Code of Federal Regulations, 2011 CFR
2011-04-01
... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Control. 202.4 Section 202.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT EMPLOYERS UNDER THE ACT § 202.4 Control. A company or person is controlled by one or more carriers, whenever there exists in one...
Code of Federal Regulations, 2013 CFR
2013-04-01
... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Control. 202.4 Section 202.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT EMPLOYERS UNDER THE ACT § 202.4 Control. A company or person is controlled by one or more carriers, whenever there exists in one...
Code of Federal Regulations, 2012 CFR
2012-04-01
... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Control. 202.4 Section 202.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT EMPLOYERS UNDER THE ACT § 202.4 Control. A company or person is controlled by one or more carriers, whenever there exists in one...
Code of Federal Regulations, 2010 CFR
2010-04-01
... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Control. 202.4 Section 202.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT EMPLOYERS UNDER THE ACT § 202.4 Control. A company or person is controlled by one or more carriers, whenever there exists in one...
Code of Federal Regulations, 2014 CFR
2014-04-01
... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Control. 202.4 Section 202.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT EMPLOYERS UNDER THE ACT § 202.4 Control. A company or person is controlled by one or more carriers, whenever there exists in one...
26 CFR 601.202 - Closing agreements.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 26 Internal Revenue 20 2010-04-01 2010-04-01 false Closing agreements. 601.202 Section 601.202... STATEMENT OF PROCEDURAL RULES Rulings and Other Specific Matters § 601.202 Closing agreements. (a) General... fact, shall be final and conclusive. (2) Closing agreements under section 7121 of the Code may relate...
46 CFR 122.202 - Notice of marine casualty.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 46 Shipping 4 2014-10-01 2014-10-01 false Notice of marine casualty. 122.202 Section 122.202... THAN 150 PASSENGERS OR WITH OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS OPERATIONS Marine Casualties and Voyage Records § 122.202 Notice of marine casualty. (a) Immediately after addressing resultant...
46 CFR 122.202 - Notice of marine casualty.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 46 Shipping 4 2012-10-01 2012-10-01 false Notice of marine casualty. 122.202 Section 122.202... THAN 150 PASSENGERS OR WITH OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS OPERATIONS Marine Casualties and Voyage Records § 122.202 Notice of marine casualty. (a) Immediately after addressing resultant...
46 CFR 122.202 - Notice of marine casualty.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 46 Shipping 4 2011-10-01 2011-10-01 false Notice of marine casualty. 122.202 Section 122.202... THAN 150 PASSENGERS OR WITH OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS OPERATIONS Marine Casualties and Voyage Records § 122.202 Notice of marine casualty. (a) Immediately after addressing resultant...
46 CFR 122.202 - Notice of marine casualty.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 46 Shipping 4 2010-10-01 2010-10-01 false Notice of marine casualty. 122.202 Section 122.202... THAN 150 PASSENGERS OR WITH OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS OPERATIONS Marine Casualties and Voyage Records § 122.202 Notice of marine casualty. (a) Immediately after addressing resultant...
46 CFR 122.202 - Notice of marine casualty.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 46 Shipping 4 2013-10-01 2013-10-01 false Notice of marine casualty. 122.202 Section 122.202... THAN 150 PASSENGERS OR WITH OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS OPERATIONS Marine Casualties and Voyage Records § 122.202 Notice of marine casualty. (a) Immediately after addressing resultant...
17 CFR 202.11 - Public Company Accounting Oversight Board budget approval process.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Public Company Accounting Oversight Board budget approval process. 202.11 Section 202.11 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION INFORMAL AND OTHER PROCEDURES § 202.11 Public Company Accounting Oversight...
7 CFR 202.1 - Meaning of words.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 3 2010-01-01 2010-01-01 false Meaning of words. 202.1 Section 202.1 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... RULES OF PRACTICE General § 202.1 Meaning of words. As used in this part, words in the singular form...
Code of Federal Regulations, 2010 CFR
2010-10-01
... 42 Public Health 4 2010-10-01 2010-10-01 false Audits. 447.202 Section 447.202 Public Health... ASSISTANCE PROGRAMS PAYMENTS FOR SERVICES Payment Methods: General Provisions § 447.202 Audits. The Medicaid agency must assure appropriate audit of records if payment is based on costs of services or on a fee plus...
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Loan amount. 500.202 Section 500.202 Business Credit and Assistance EMERGENCY OIL AND GAS GUARANTEED LOAN BOARD EMERGENCY OIL AND GAS GUARANTEED LOAN PROGRAM Oil and Gas Guaranteed Loans § 500.202 Loan amount. The aggregate amount of loan...
36 CFR 905.735-202 - Gifts, entertainment, and favors.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Gifts, entertainment, and favors. 905.735-202 Section 905.735-202 Parks, Forests, and Public Property PENNSYLVANIA AVENUE..., entertainment, and favors. Pursuant to paragraph (b) of 5 CFR 735.202, the following exceptions to the...
36 CFR 905.735-202 - Gifts, entertainment, and favors.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Gifts, entertainment, and favors. 905.735-202 Section 905.735-202 Parks, Forests, and Public Property PENNSYLVANIA AVENUE..., entertainment, and favors. Pursuant to paragraph (b) of 5 CFR 735.202, the following exceptions to the...
36 CFR 905.735-202 - Gifts, entertainment, and favors.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Gifts, entertainment, and favors. 905.735-202 Section 905.735-202 Parks, Forests, and Public Property PENNSYLVANIA AVENUE..., entertainment, and favors. Pursuant to paragraph (b) of 5 CFR 735.202, the following exceptions to the...
78 FR 21497 - Publication of General Licenses Related to the Burma Sanctions Program
Federal Register 2010, 2011, 2012, 2013, 2014
2013-04-10
... General License No. 19. FOR FURTHER INFORMATION CONTACT: Assistant Director for Sanctions Compliance & Evaluation, tel.: 202-622-2490, Assistant Director for Licensing, tel.: 202-622-2480, Assistant Director for Regulatory Affairs, tel.: 202-622-4855, Assistant Director for Policy, tel.: 202- 622-2746, Office of Foreign...
48 CFR 19.202-6 - Determination of fair market price.
Code of Federal Regulations, 2010 CFR
2010-10-01
... market price. 19.202-6 Section 19.202-6 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 19.202-6 Determination of fair market price. (a) The fair market price shall be the price achieved in accordance with the reasonable price...
41 CFR 50-202.1 - Application and scope.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Application and scope. 50-202.1 Section 50-202.1 Public Contracts and Property Management Other Provisions Relating to Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 202-MINIMUM WAGE DETERMINATIONS Application and Scope § 50...
41 CFR 50-202.1 - Application and scope.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 41 Public Contracts and Property Management 1 2012-07-01 2009-07-01 true Application and scope. 50-202.1 Section 50-202.1 Public Contracts and Property Management Other Provisions Relating to Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 202-MINIMUM WAGE DETERMINATIONS Application and Scope § 50...
41 CFR 50-202.1 - Application and scope.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Application and scope. 50-202.1 Section 50-202.1 Public Contracts and Property Management Other Provisions Relating to Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 202-MINIMUM WAGE DETERMINATIONS Application and Scope § 50...
46 CFR 199.202 - Rescue boats.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 46 Shipping 7 2012-10-01 2012-10-01 false Rescue boats. 199.202 Section 199.202 Shipping COAST... SYSTEMS FOR CERTAIN INSPECTED VESSELS Additional Requirements for Passenger Vessels § 199.202 Rescue boats... least one rescue boat approved under approval series 160.156 that is equipped as specified in table 199...
46 CFR 199.202 - Rescue boats.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 46 Shipping 7 2010-10-01 2010-10-01 false Rescue boats. 199.202 Section 199.202 Shipping COAST... SYSTEMS FOR CERTAIN INSPECTED VESSELS Additional Requirements for Passenger Vessels § 199.202 Rescue boats... least one rescue boat approved under approval series 160.156 that is equipped as specified in table 199...
46 CFR 199.202 - Rescue boats.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 46 Shipping 7 2013-10-01 2013-10-01 false Rescue boats. 199.202 Section 199.202 Shipping COAST... SYSTEMS FOR CERTAIN INSPECTED VESSELS Additional Requirements for Passenger Vessels § 199.202 Rescue boats... least one rescue boat approved under approval series 160.156 that is equipped as specified in table 199...
46 CFR 199.202 - Rescue boats.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 46 Shipping 7 2011-10-01 2011-10-01 false Rescue boats. 199.202 Section 199.202 Shipping COAST... SYSTEMS FOR CERTAIN INSPECTED VESSELS Additional Requirements for Passenger Vessels § 199.202 Rescue boats... least one rescue boat approved under approval series 160.156 that is equipped as specified in table 199...
46 CFR 199.202 - Rescue boats.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 46 Shipping 7 2014-10-01 2014-10-01 false Rescue boats. 199.202 Section 199.202 Shipping COAST... SYSTEMS FOR CERTAIN INSPECTED VESSELS Additional Requirements for Passenger Vessels § 199.202 Rescue boats... least one rescue boat approved under approval series 160.156 that is equipped as specified in table 199...
Code of Federal Regulations, 2014 CFR
2014-01-01
... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Coverage. 534.202 Section 534.202...-Employees in Government Hospitals § 534.202 Coverage. In addition to the student-employees specified in 5 U... this program whom the Office of Personnel Management approves for coverage as a student-employee under...
Code of Federal Regulations, 2013 CFR
2013-01-01
... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Coverage. 534.202 Section 534.202...-Employees in Government Hospitals § 534.202 Coverage. In addition to the student-employees specified in 5 U... this program whom the Office of Personnel Management approves for coverage as a student-employee under...
Code of Federal Regulations, 2011 CFR
2011-01-01
... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Coverage. 534.202 Section 534.202...-Employees in Government Hospitals § 534.202 Coverage. In addition to the student-employees specified in 5 U... this program whom the Office of Personnel Management approves for coverage as a student-employee under...
Code of Federal Regulations, 2012 CFR
2012-01-01
... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Coverage. 534.202 Section 534.202...-Employees in Government Hospitals § 534.202 Coverage. In addition to the student-employees specified in 5 U... this program whom the Office of Personnel Management approves for coverage as a student-employee under...
41 CFR 105-50.202-6 - Communications services.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Communications services. 105-50.202-6 Section 105-50.202-6 Public Contracts and Property Management Federal Property Management... § 105-50.202-6 Communications services. GSA will continue to make its bulk rate circuit ordering...
40 CFR 1065.202 - Data updating, recording, and control.
Code of Federal Regulations, 2011 CFR
2011-07-01
.... 1065.202 Section 1065.202 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Measurement Instruments § 1065.202 Data updating, recording... Intake-air or raw-exhaust flow rate N/A 1 Hz means. § 1065.530, § 1065.545 Dilution air if actively...
40 CFR 1065.202 - Data updating, recording, and control.
Code of Federal Regulations, 2014 CFR
2014-07-01
.... 1065.202 Section 1065.202 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Measurement Instruments § 1065.202 Data updating, recording...; § 1065.545 Intake-air or raw-exhaust flow rate 1 Hz means. § 1065.530; § 1065.545 Dilution air flow if...
40 CFR 1065.202 - Data updating, recording, and control.
Code of Federal Regulations, 2012 CFR
2012-07-01
.... 1065.202 Section 1065.202 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Measurement Instruments § 1065.202 Data updating, recording... Intake-air or raw-exhaust flow rate N/A 1 Hz means. § 1065.530, § 1065.545 Dilution air if actively...
40 CFR 1065.202 - Data updating, recording, and control.
Code of Federal Regulations, 2013 CFR
2013-07-01
.... 1065.202 Section 1065.202 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Measurement Instruments § 1065.202 Data updating, recording... Intake-air or raw-exhaust flow rate N/A 1 Hz means. § 1065.530, § 1065.545 Dilution air if actively...
30 CFR 202.152 - Standards for reporting and paying royalties on gas.
Code of Federal Regulations, 2010 CFR
2010-07-01
... same standards specified in paragraph (a) of this section. (3) Natural gas liquids (NGL) volumes shall... gas. 202.152 Section 202.152 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT ROYALTIES Federal Gas § 202.152 Standards for reporting and paying royalties on...
30 CFR 202.150 - Royalty on gas.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Royalty on gas. 202.150 Section 202.150 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT ROYALTIES Federal Gas § 202.150 Royalty on gas. (a) Royalties due on gas production from leases subject to the...
30 CFR 202.101 - Standards for reporting and paying royalties.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Standards for reporting and paying royalties. 202.101 Section 202.101 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT ROYALTIES Federal and Indian Oil § 202.101 Standards for reporting and paying...
12 CFR 268.202 - Equal Pay Act.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Equal Pay Act. 268.202 Section 268.202 Banks... REGARDING EQUAL OPPORTUNITY Provisions Applicable to Particular Complaints § 268.202 Equal Pay Act. Complaints alleging violations of the Equal Pay Act shall be processed under this part. ...
48 CFR 18.202 - Defense or recovery from certain attacks.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Defense or recovery from certain attacks. 18.202 Section 18.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Emergency Acquisition Flexibilities 18.202 Defense or recovery from certain...
48 CFR 819.202-70 - HCA responsibilities.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false HCA responsibilities. 819.202-70 Section 819.202-70 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 819.202-70 HCA responsibilities. An HCA must perform the following functions in support of the...
48 CFR 819.202-70 - HCA responsibilities.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false HCA responsibilities. 819.202-70 Section 819.202-70 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 819.202-70 HCA responsibilities. An HCA must perform the following functions in support of the...
48 CFR 819.202-70 - HCA responsibilities.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false HCA responsibilities. 819.202-70 Section 819.202-70 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 819.202-70 HCA responsibilities. An HCA must perform the following functions in support of the...
48 CFR 819.202-70 - HCA responsibilities.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false HCA responsibilities. 819.202-70 Section 819.202-70 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 819.202-70 HCA responsibilities. An HCA must perform the following functions in support of the...
48 CFR 819.202-70 - HCA responsibilities.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false HCA responsibilities. 819.202-70 Section 819.202-70 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 819.202-70 HCA responsibilities. An HCA must perform the following functions in support of the...
(C6H13N)2BiI5: A One-Dimensional Lead-Free Perovskite-Derivative Photoconductive Light Absorber.
Zhang, Weichuan; Tao, Kewen; Ji, Chengmin; Sun, Zhihua; Han, Shiguo; Zhang, Jing; Wu, Zhenyue; Luo, Junhua
2018-04-16
Lead-free organic-inorganic hybrid perovskites have recently attracted intense interest as environmentally friendly, low-cost, chemically stable light absorbers. Here, we reported a new one-dimensional (1D) zigzag chainlike light-absorbing hybrid material of (C 6 H 13 N) 2 BiI 5 , in which the corner-sharing octahedral bismuth halide chains are surrounded by organic cations of tetramethylpiperidinium. This unique zigzag 1D hybrid perovskite-derivative material shows a narrow direct band gap of 2.02 eV and long-lived photoluminescence, which is encouraging for optoelectronic applications. Importantly, it behaves as a typical semiconducting material and displays obvious photoresponse in the visible-light range. This work opens a potential pathway for the further application of 1D lead-free hybrids.
Draft genome sequence of the coccolithovirus Emiliania huxleyi virus 202.
Nissimov, Jozef I; Worthy, Charlotte A; Rooks, Paul; Napier, Johnathan A; Kimmance, Susan A; Henn, Matthew R; Ogata, Hiroyuki; Allen, Michael J
2012-02-01
Emiliania huxleyi virus 202 (EhV-202) is a member of the Coccolithoviridae, a group of viruses that infect the marine coccolithophorid Emiliania huxleyi. EhV-202 has a 160- to 180-nm-diameter icosahedral structure and a genome of approximately 407 kbp, consisting of 485 coding sequences (CDSs). Here we describe the genomic features of EhV-202, together with a draft genome sequence and its annotation, highlighting the homology and heterogeneity of this genome in comparison with the EhV-86 reference genome.
Towards the specification of consecutive steps in macromolecular lignin assembly.
Nose, M; Bernards, M A; Furlan, M; Zajicek, J; Eberhardt, T L; Lewis, N G
1995-05-01
When Pinus taeda cell suspension cultures are exposed to 8% sucrose solution, the cells undergo significant intracellular disruption, irregular wall thickening/lignification with concomitant formation of an 'extracellular lignin precipitate. However, addition of potassium iodide (KI), an H202 scavenger, inhibits this lignification response, while the ability to synthesize the monolignols, p-coumaryl and coniferyl alcohols, is retained. Lignin synthesis (i.e. polymerization) is thus temporarily correlated with H202 generation, strongly implying a regulatory role for the latter. Time course analyses of extracellular metabolites leading up to polymer formation reveal that coniferyl alcohol, but not p-coumaryl alcohol, undergoes substantial coupling reactions to give various lignans. Of these, the metabolites, dihydrodehydrodiconiferyl alcohol, shonanin (divanillyl tetrahydrofuran) and its apparent aryl tetralin derivative, cannot be explained simply on the basis of phenolic coupling. It is proposed that these moieties are the precursors of so-called reduced substructures in the lignin macromolecule. This adds a new perspective to the lignin assembly mechanism.
Towards the specification of consecutive steps in macromolecular lignin assembly
NASA Technical Reports Server (NTRS)
Nose, M.; Bernards, M. A.; Furlan, M.; Zajicek, J.; Eberhardt, T. L.; Lewis, N. G.
1995-01-01
When Pinus taeda cell suspension cultures are exposed to 8% sucrose solution, the cells undergo significant intracellular disruption, irregular wall thickening/lignification with concomitant formation of an 'extracellular lignin precipitate. However, addition of potassium iodide (KI), an H202 scavenger, inhibits this lignification response, while the ability to synthesize the monolignols, p-coumaryl and coniferyl alcohols, is retained. Lignin synthesis (i.e. polymerization) is thus temporarily correlated with H202 generation, strongly implying a regulatory role for the latter. Time course analyses of extracellular metabolites leading up to polymer formation reveal that coniferyl alcohol, but not p-coumaryl alcohol, undergoes substantial coupling reactions to give various lignans. Of these, the metabolites, dihydrodehydrodiconiferyl alcohol, shonanin (divanillyl tetrahydrofuran) and its apparent aryl tetralin derivative, cannot be explained simply on the basis of phenolic coupling. It is proposed that these moieties are the precursors of so-called reduced substructures in the lignin macromolecule. This adds a new perspective to the lignin assembly mechanism.
Peltier, Chad; Becker, Mark W
2017-05-01
Target prevalence influences visual search behavior. At low target prevalence, miss rates are high and false alarms are low, while the opposite is true at high prevalence. Several models of search aim to describe search behavior, one of which has been specifically intended to model search at varying prevalence levels. The multiple decision model (Wolfe & Van Wert, Current Biology, 20(2), 121--124, 2010) posits that all searches that end before the observer detects a target result in a target-absent response. However, researchers have found very high false alarms in high-prevalence searches, suggesting that prevalence rates may be used as a source of information to make "educated guesses" after search termination. Here, we further examine the ability for prevalence level and knowledge gained during visual search to influence guessing rates. We manipulate target prevalence and the amount of information that an observer accumulates about a search display prior to making a response to test if these sources of evidence are used to inform target present guess rates. We find that observers use both information about target prevalence rates and information about the proportion of the array inspected prior to making a response allowing them to make an informed and statistically driven guess about the target's presence.
48 CFR 1019.202-70 - The Treasury Mentor-Protégé Program.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false The Treasury Mentor-Protégé Program. 1019.202-70 Section 1019.202-70 Federal Acquisition Regulations System DEPARTMENT OF THE TREASURY SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 1019.202-70 The Treasury Mentor...
Code of Federal Regulations, 2012 CFR
2012-01-01
... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Hearing. 202.5 Section 202.5 Animals... STOCKYARDS ACT Rules of Practice Applicable to Rate Proceedings § 202.5 Hearing. The hearing will be oral unless all parties waive oral hearing. It will be written if not oral. Notice of the date, time and place...
Code of Federal Regulations, 2011 CFR
2011-01-01
... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Hearing. 202.5 Section 202.5 Animals... STOCKYARDS ACT Rules of Practice Applicable to Rate Proceedings § 202.5 Hearing. The hearing will be oral unless all parties waive oral hearing. It will be written if not oral. Notice of the date, time and place...
Code of Federal Regulations, 2014 CFR
2014-01-01
... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Hearing. 202.5 Section 202.5 Animals... STOCKYARDS ACT Rules of Practice Applicable to Rate Proceedings § 202.5 Hearing. The hearing will be oral unless all parties waive oral hearing. It will be written if not oral. Notice of the date, time and place...
78 FR 48152 - Advisory Committee on Student Financial Assistance; Meeting
Federal Register 2010, 2011, 2012, 2013, 2014
2013-08-07
..., 80 F Street NW., Suite 413, Washington DC 20202-7582, (202) 219- 2099. SUPPLEMENTARY INFORMATION: The... at (202) 219-3032. You may also contact the Advisory Committee staff directly at (202) 219-2099. The..., August 21, 2013 by contacting Ms. Tracy Jones at (202) 219-2099 or via email at [email protected
Code of Federal Regulations, 2010 CFR
2010-10-01
... for United States Agency for International Development (USAID) programs. 470.202 Section 470.202... ACQUISITIONS 470.202 Acquisition of commodities for United States Agency for International Development (USAID... organization to require, an ocean carrier to submit offers electronically through a Web-based system maintained...
10 CFR 830.202 - Safety basis.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 10 Energy 4 2011-01-01 2011-01-01 false Safety basis. 830.202 Section 830.202 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.202 Safety basis. (a) The contractor responsible for a hazard category 1, 2, or 3 DOE nuclear facility must establish and maintain the safety basis...
48 CFR 1019.202-70-12 - Agreement contents.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Agreement contents. 1019.202-70-12 Section 1019.202-70-12 Federal Acquisition Regulations System DEPARTMENT OF THE TREASURY SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 1019.202-70-12 Agreement contents. The contents of the agreement will contain: (a) Names and...