ISLE (Image and Signal Processing LISP Environment) reference manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sherwood, R.J.; Searfus, R.M.

1990-01-01

ISLE is a rapid prototyping system for performing image and signal processing. It is designed to meet the needs of a person doing development of image and signal processing algorithms in a research environment. The image and signal processing modules in ISLE form a very capable package in themselves. They also provide a rich environment for quickly and easily integrating user-written software modules into the package. ISLE is well suited to applications in which there is a need to develop a processing algorithm in an interactive manner. It is straightforward to develop the algorithms, load it into ISLE, apply themore » algorithm to an image or signal, display the results, then modify the algorithm and repeat the develop-load-apply-display cycle. ISLE consists of a collection of image and signal processing modules integrated into a cohesive package through a standard command interpreter. ISLE developer elected to concentrate their effort on developing image and signal processing software rather than developing a command interpreter. A COMMON LISP interpreter was selected for the command interpreter because it already has the features desired in a command interpreter, it supports dynamic loading of modules for customization purposes, it supports run-time parameter and argument type checking, it is very well documented, and it is a commercially supported product. This manual is intended to be a reference manual for the ISLE functions The functions are grouped into a number of categories and briefly discussed in the Function Summary chapter. The full descriptions of the functions and all their arguments are given in the Function Descriptions chapter. 6 refs.« less

Field Philosophy: Environmental Learning and Moral Development in Isle Royale National Park

ERIC Educational Resources Information Center

Goralnik, Lissy; Nelson, Michael Paul

2017-01-01

We conducted a qualitative analysis of 5 years of student writing data to understand learning and moral development on a field philosophy course in Isle Royale National Park. We were interested in the connection between physical experiences in the natural world and the way students care about or value nonhuman beings, natural systems, and place.…

ISLE (Image and Signal LISP Environment): A functional language interface for signal and image processing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Azevedo, S.G.; Fitch, J.P.

1987-10-21

Conventional software interfaces that use imperative computer commands or menu interactions are often restrictive environments when used for researching new algorithms or analyzing processed experimental data. We found this to be true with current signal-processing software (SIG). As an alternative, ''functional language'' interfaces provide features such as command nesting for a more natural interaction with the data. The Image and Signal LISP Environment (ISLE) is an example of an interpreted functional language interface based on common LISP. Advantages of ISLE include multidimensional and multiple data-type independence through dispatching functions, dynamic loading of new functions, and connections to artificial intelligence (AI)more » software. 10 refs.« less

Annotated Bibliography for Lake Erie. Volume IV. Physical,

DTIC Science & Technology

1974-10-01

Presque Isle Bay, Erie , Pennsylvania - interim report. Environ- mental Sciences Inc. Pittsburg, Pa. 235 P. The factors... Presque Isle Peninsula, Erie , Pennsylvania , indicates apparent correlation of initial high erosion rates of placed beach fill with sand size character...changes since 1854. (CE) 777. U. S. Army Corps of Engineers. 1960. Presque Isle Peninsula, Erie , Pennsylvania , beach erosion con- trol study.

Isle Royale National Park transportation study

DOT National Transportation Integrated Search

2015-04-02

Isle Royale National Park is a remote archipelago located in western Lake Superior, fourteen miles from the closest mainland and 60 : miles from the parks headquarters in Houghton, MI. While visitors treasure the parks pristine environment and sol...

Exploring international clinical education in US-based programs: identifying common practices and modifying an existing conceptual model of international service-learning.

PubMed

Pechak, Celia M; Black, Jill D

2014-02-01

Increasingly physical therapist students complete part of their clinical training outside of their home country. This trend is understudied. The purposes of this study were to: (1) explore, in depth, various international clinical education (ICE) programs; and (2) determine whether the Conceptual Model of Optimal International Service-Learning (ISL) could be applied or adapted to represent ICE. Qualitative content analysis was used to analyze ICE programs and consider modification of an existing ISL conceptual model for ICE. Fifteen faculty in the United States currently involved in ICE were interviewed. The interview transcriptions were systematically analyzed by two researchers. Three models of ICE practices emerged: (1) a traditional clinical education model where local clinical instructors (CIs) focus on the development of clinical skills; (2) a global health model where US-based CIs provide the supervision in the international setting, and learning outcomes emphasized global health and cultural competency; and (3) an ICE/ISL hybrid where US-based CIs supervise the students, and the foci includes community service. Additionally the data supported revising the ISL model's essential core conditions, components and consequence for ICE. The ICE conceptual model may provide a useful framework for future ICE program development and research.

How gender and reformed introductory physics impacts student success in advanced physics courses and continuation in the physics major

NASA Astrophysics Data System (ADS)

Rodriguez, Idaykis; Potvin, Geoff; Kramer, Laird H.

2016-12-01

[This paper is part of the Focused Collection on Gender in Physics.] Active-learning approaches to teaching introductory physics have been found to improve student learning and affective gains on short-term outcomes [S. Freeman et al., Proc. Natl. Acad. Sci. U.S.A. 111, 8410 (2014)]; however, whether or not the benefits of active learning impact women to the same degree as men has been a point of concern [A. Madsen, S. B. McKagan, and E. C. Sayre, Phys. Rev. ST Phys. Educ. Res. 9, 020121 (2013)]. Further, the long-term impacts of active-learning experiences are also understudied. At Florida International University, a Hispanic-majority institution, we have implemented Modeling Instruction (MI) and the Integrated Science Learning Environment (ISLE) in introductory physics classes for the past decade. In this empirical paper, we report on a longitudinal investigation of student performance and persistence in upper level physics courses after having previously experienced MI or ISLE in their introductory physics courses, and disaggregate students by gender. Using survival analysis methods, we find women who declare physics as a major are more likely than men to graduate with a physics degree. Women are also just as likely as men to pass through the upper division courses, with the highest failure risk for both men and women occurring in the first semester of upper-division course taking. These results reinforce the need to expand considerations of performance outcomes to be longitudinal to measure the effectiveness of the entire physics experience.

International service learning and interprofessional education in Ecuador: Findings from a phenomenology study with students from four professions.

PubMed

Johnson, Audrey M; Howell, Dana M

2017-03-01

Combined international service learning (ISL) and interprofessional education (IPE) experiences can move health professional student learning beyond the traditional confines of the classroom and outside uniprofessional ethos. The purpose of this transcendental phenomenological study was to describe the shared experience of health professional students participating in an ISL trip to a small community in Ecuador. The study focused on the learning and collaboration that occurred among students from multiple health professions during the trip and the cross-cultural exchange between the students and the patients in Ecuador. Participants included 15 students from 4 health professional programmes (pharmacy, medicine, physical therapy, and nursing). Data included interviews, focus groups, observation, and written documents. The essential meaning that emerged from this study was that the ISL/IPE learning opportunity created a practical opportunity for demystifying other healthcare professions in the context of a resource-limited international patient care setting, while supporting students' personal and professional development. Four structural themes emerged to describe the student experiences. Students had to negotiate the language barrier, limited resources, and unexpected diagnoses, while simultaneously learning about the roles and scope of other professions on the team and how to communicate effectively. Student's perseverance when facing the challenges resulted in their personal growth. The interprofessional component strengthened the students' knowledge of interprofessional collaboration and communication through real-world application.

76 FR 60525 - Final Wilderness and Backcountry Management Plan and Environmental Impact Statement for Isle...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-29

... and Environmental Impact Statement for Isle Royale National Park, MI AGENCY: National Park Service... the availability of a Final Wilderness and Backcountry Management Plan and Environmental Impact... the Internet through the NPS Planning, Environment, and Public Comment Web site ( http://parkplanning...

Transformative Education through International Service-­Learning: Realising an Ethical Ecology of Learning. Routledge Research in International and Comparative Education

ERIC Educational Resources Information Center

Bamber, Philip M.

2016-01-01

Transformative learning is a compelling approach to learning that is becoming increasingly popular in a diverse range of educational settings and encounters. This book reconceptualises transformative learning through an investigation of the learning process and outcomes of International Service-Learning (ISL), a pedagogical approach that blends…

Research on Internet-Supported Learning: A Review

ERIC Educational Resources Information Center

Bekele, Teklu Abate; Menchaca, Michael Paul

2008-01-01

How did the Internet affect learning in higher education? What methodological and theoretical issues characterized research on Internet-Supported Learning (ISL)? What implications existed for future research? A constant comparative, qualitative analysis of 29 studies indicated grade achievement was the prime measure of effectiveness in ISL…

Analysis of an Interactive Technology Supported Problem-Based Learning STEM Project Using Selected Learning Sciences Interest Areas (SLSIA)

ERIC Educational Resources Information Center

Kumar, David Devraj

2017-01-01

This paper reports an analysis of an interactive technology-supported, problem-based learning (PBL) project in science, technology, engineering and mathematics (STEM) from a Learning Sciences perspective using the Selected Learning Sciences Interest Areas (SLSIA). The SLSIA was adapted from the "What kinds of topics do ISLS [International…

Act Local or Global?: Comparing Student Experiences in Domestic and International Service-Learning Programs

ERIC Educational Resources Information Center

Niehaus, Elizabeth; Crain, Léna Kavaliauskas

2013-01-01

International service-learning (ISL) is a popular way to facilitate student growth in the areas of cross-cultural learning and civic engagement. However, many have questioned whether international trips provide any added value compared to domestic service-learning. Using the context of Alternative Break programs, this study compares student…

Participation in Informal Science Learning Experiences: The Rich Get Richer?

ERIC Educational Resources Information Center

DeWitt, Jennifer; Archer, Louise

2017-01-01

Informal science learning (ISL) experiences have been found to provide valuable opportunities to engage with and learn about science and, as such, form a key part of the STEM learning ecosystem. However, concerns remain around issues of equity and access. The Enterprising Science study builds upon previous research in this area and uses the…

A mixed methods evaluation of an international service learning program in the Dominican Republic.

PubMed

Curtin, Alicia J; Martins, Diane C; Schwartz-Barcott, Donna

2015-01-01

To examine the impact of an international service learning experience (ISL) using a quantitative and qualitative approach. A descriptive study was used to explore the impact of an ISL experience on global awareness, professional and personal growth with 11 baccalaureate nursing students in the Dominican Republic. Students participated in a three credit ISL program in the Dominican Republic which included pre- and postexperience seminars and a 2-week, on-site immersion experience. The International Education Survey (IES) was used as the quantitative measure. Content analysis of Critical Reflective Inquiry (CRI) narratives was used as the qualitative method. Students reported a high overall impact (M = 5.9) using the IES with high means for the Professional Student Nurse Role (M = 6.10, SD: 0.74), Personal Development (M = 6.08, SD: 0.76), International Perspectives (M = 6.03, SD: 0.71), and a lower mean for Intellectual Development (M = 5.40, SD: 0.69). CRI narratives revealed specific areas of impact, for example, increased empathy and ability to communicate effectively with patients from life situations very different from their own. Further exploration of the usefulness of various evaluation tools and methodological designs is warranted to understand this type of pedagogy and its' impact on student learning outcomes short- and long-term. © 2014 Wiley Periodicals, Inc.

ISLE (Image and Signal Lisp Environment): A functional language interface for signal and image processing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Azevedo, S.G.; Fitch, J.P.

1987-05-01

Conventional software interfaces which utilize imperative computer commands or menu interactions are often restrictive environments when used for researching new algorithms or analyzing processed experimental data. We found this to be true with current signal processing software (SIG). Existing ''functional language'' interfaces provide features such as command nesting for a more natural interaction with the data. The Image and Signal Lisp Environment (ISLE) will be discussed as an example of an interpreted functional language interface based on Common LISP. Additional benefits include multidimensional and multiple data-type independence through dispatching functions, dynamic loading of new functions, and connections to artificial intelligencemore » software.« less

Islet-1 Controls the Differentiation of Retinal Bipolar and Cholinergic Amacrine Cells

PubMed Central

Elshatory, Yasser; Everhart, Drew; Deng, Min; Xie, Xiaoling; Barlow, Robert B.; Gan, Lin

2010-01-01

Whereas the mammalian retina possesses a repertoire of factors known to establish general retinal cell types, these factors alone cannot explain the vast diversity of neuronal subtypes. In other CNS regions, the differentiation of diverse neuronal pools is governed by coordinately acting LIM-homeodomain proteins including the Islet-class factor Islet-1 (Isl1). We report that deletion of Isl1 profoundly disrupts retinal function as assessed by electroretinograms and vision as assessed by optomotor behavior. These deficits are coupled with marked reductions in mature ON- and OFF-bipolar (>76%), cholinergic amacrine (93%), and ganglion (71%) cells. Mosaic deletion of Isl1 permitted a chimeric analysis of “wild-type” cells in a predominantly Isl1-null environment, demonstrating a cell-autonomous role for Isl1 in rod bipolar and cholinergic amacrine development. Furthermore, the effects on bipolar cell development appear to be dissociable from the preceding retinal ganglion cell loss, because Pou4f2-null mice are devoid of similar defects in bipolar cell marker expression. Expression of the ON- and OFF-bipolar cell differentiation factors Bhlhb4 and Vsx1, respectively, requires the presence of Isl1, whereas the early bipolar cell marker Prox1 initially did not. Thus, Isl1 is required for engaging bipolar differentiation pathways but not for general bipolar cell specification. Spatiotemporal expression analysis of additional LIM-homeobox genes identifies a LIM-homeobox gene network during bipolar cell development that includes Lhx3 and Lhx4. We conclude that Isl1 has an indispensable role in retinal neuron differentiation within restricted cell populations and this function may reflect a broader role for other LIM-homeobox genes in retinal development, and perhaps in establishing neuronal subtypes. PMID:18003851

Methods and Strategies:Students as Authors

ERIC Educational Resources Information Center

Varelas, Maria; Pappas, Christine C.; Kokkino, Sofia; Ortiz, Ibett

2008-01-01

Are you looking for ways to effectively integrate--and assess--science and literacy learning? Try having your students create their own books! The Integrated Science Literacy Enactments (ISLE) approach to teaching and learning science is one way to develop students' science understandings while simultaneously enhancing their communication skills.…

Service user preferences for diabetes education in remote and rural areas of the Highlands and Islands of Scotland.

PubMed

Hall, Jenny; Skinner, Fiona; Tilley, Phil; MacRury, Sandra

2018-03-01

Diabetes prevalence in Scotland is 5.3%, with type 2 diabetes accounting for 86.7% of all cases in the National Health Service Highlands health board area and 85.7% in the Western Isles. Structured education is a key component in the management of this chronic disease. However, current group session models are less feasible in lower-population non-urban environments due to distance, participant numbers and access to appropriately trained healthcare professionals. Group sessions may also be a less attractive option in small communities, where people tend to have close day-to-day personal contact. This study assesses the access and delivery preferences of remote and rural service users in the Highlands and Western Isles to structured diabetes education programs. The study used a mixed methods approach of focus groups and questionnaires with people with type 2 diabetes in the Highlands and Islands of Scotland. Both modes of participation were designed to explore perception of diabetes knowledge, diabetes education and use of technology. One-to-one delivery was the delivery method of choice; however, there was a preference for a digital approach over group education sessions. Service users expressed a strong desire to be able to learn at their own pace, when and where they wanted to, and with no requirement to travel. To address these requirements an online resource, providing access to both learning sessions and trusted sources of information, was the preferred mode of delivery. People with type 2 diabetes living in remote and rural areas of the Scottish Highlands and Islands who already use the internet are receptive to the use of digital technology for delivery of diabetes education and are interested in learning more about management of their condition through this medium. They believe that a technology approach will provide them with more control over the pace of learning, and where and when this learning can take place.

Survival at Isle Royale.

ERIC Educational Resources Information Center

Ballone, Lena M.

2001-01-01

Describes a simulation based on the popular television show "Survivor" in which students work in groups and study physiological needs for human survival. Focuses on communication skills, problem solving, and cooperative learning. (YDS)

Can common measures of core stability distinguish performance in a shoulder pressing task under stable and unstable conditions?

PubMed

Keogh, Justin W L; Aickin, Sam E; Oldham, Anthony R H

2010-02-01

The primary purpose of this study was to determine whether a range of static core stability (CS) measures could distinguish shoulder press performance in unstable vs. stable conditions. Thirty resistance-trained men gave informed consent to participate in this study. One-repetition maximum strength (from < 6 repetitions) was predicted in the seated shoulder dumbbell press performed in unstable (Swiss ball[SB]) and stable (back-support bench) environments. Three CS muscle endurance tests were performed, with 4 CS ratios also calculated. The degree of strength decrement, referred to as the instability strength level (ISL), was calculated by dividing the predicted 1RM Unstable score by the 1RM Stable score. All subjects were categorized as high (ISL > 0.90), moderate (0.85 < or = ISL < or = 0.90), or low (ISL < 0.85). Between-group differences for the high- and low-ISL groups were assessed using analysis of variance and effect sizes. Pearson product moment correlations were then performed to examine the relationships between the CS measures and the ISL for the entire group. No significant between-group differences (p = 0.132-0.999) or large effect sizes were observed for any of the CS measures. Trunk flexion endurance was the only CS measure significantly correlated to the ISL (r = 0.477). In line with muscular strength research, these results suggest that CS exhibits relatively high levels of task specificity and that CS performance in static single-joint exercises may not be highly related to that in more dynamic multijoint activities. Core stability training (with or without a SB) may therefore only lead to significant improvements in functional dynamic performance if the postures, mode and velocity of contraction performed in training, are similar to the competitive tasks.

In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images.

PubMed

Christiansen, Eric M; Yang, Samuel J; Ando, D Michael; Javaherian, Ashkan; Skibinski, Gaia; Lipnick, Scott; Mount, Elliot; O'Neil, Alison; Shah, Kevan; Lee, Alicia K; Goyal, Piyush; Fedus, William; Poplin, Ryan; Esteva, Andre; Berndl, Marc; Rubin, Lee L; Nelson, Philip; Finkbeiner, Steven

2018-04-19

Microscopy is a central method in life sciences. Many popular methods, such as antibody labeling, are used to add physical fluorescent labels to specific cellular constituents. However, these approaches have significant drawbacks, including inconsistency; limitations in the number of simultaneous labels because of spectral overlap; and necessary perturbations of the experiment, such as fixing the cells, to generate the measurement. Here, we show that a computational machine-learning approach, which we call "in silico labeling" (ISL), reliably predicts some fluorescent labels from transmitted-light images of unlabeled fixed or live biological samples. ISL predicts a range of labels, such as those for nuclei, cell type (e.g., neural), and cell state (e.g., cell death). Because prediction happens in silico, the method is consistent, is not limited by spectral overlap, and does not disturb the experiment. ISL generates biological measurements that would otherwise be problematic or impossible to acquire. Copyright © 2018 Elsevier Inc. All rights reserved.

University Service-Learning Partnership with a Foreign Government: A Case Study

ERIC Educational Resources Information Center

Guseh, James S.

2015-01-01

The purpose of this research is to assess the process of establishing, implementing, and evaluating an international service-learning (ISL) partnership between an American university and a foreign government. The partnership is between North Carolina Central University and the Civil Service Agency of Liberia. In order to facilitate an in-depth…

A Case Study of Partnerships in International Service Learning: Exploring Reciprocity and Bi-Directional Benefits

ERIC Educational Resources Information Center

Healey-Walsh, Judith

2016-01-01

Based on demographic shifts toward more diversity and increasing health care disparities in the United States, nursing educators have been called upon to find innovative pedagogies to teach cultural competence and social justice concepts. International service-learning programs (ISL) are proliferating, as there is evidence that these experiences…

A Partnership Approach to Action Learning within a Masters Educational Programme

ERIC Educational Resources Information Center

Harrison, Patricia; Edwards, Carys

2012-01-01

This account of practice provides a practical example of the use of action learning within a masters educational programme, an MA in Change Management designed and delivered by a collaborative partnership between the Isle of Anglesey County Council (ACC) and Liverpool Business School (LBS), Liverpool John Moores University. The account has been…

Incremental social learning in particle swarms.

PubMed

de Oca, Marco A Montes; Stutzle, Thomas; Van den Enden, Ken; Dorigo, Marco

2011-04-01

Incremental social learning (ISL) was proposed as a way to improve the scalability of systems composed of multiple learning agents. In this paper, we show that ISL can be very useful to improve the performance of population-based optimization algorithms. Our study focuses on two particle swarm optimization (PSO) algorithms: a) the incremental particle swarm optimizer (IPSO), which is a PSO algorithm with a growing population size in which the initial position of new particles is biased toward the best-so-far solution, and b) the incremental particle swarm optimizer with local search (IPSOLS), in which solutions are further improved through a local search procedure. We first derive analytically the probability density function induced by the proposed initialization rule applied to new particles. Then, we compare the performance of IPSO and IPSOLS on a set of benchmark functions with that of other PSO algorithms (with and without local search) and a random restart local search algorithm. Finally, we measure the benefits of using incremental social learning on PSO algorithms by running IPSO and IPSOLS on problems with different fitness distance correlations.

Using Web 2.0 for Learning in the Community

ERIC Educational Resources Information Center

Mason, Robin; Rennie, Frank

2007-01-01

This paper describes the use of a range of Web 2.0 technologies to support the development of community for a newly formed Land Trust on the Isle of Lewis, in NW Scotland. The application of social networking tools in text, audio and video has several purposes: informal learning about the area to increase tourism, community interaction,…

The Role of International Service-Learning in Facilitating Undergraduate Students' Self-Exploration

ERIC Educational Resources Information Center

Yang, Min; Luk, Lillian Yun Yung; Webster, Beverley Joyce; Chau, Albert Wai-lap; Ma, Carol Hok Ka

2016-01-01

This article examines the role of international service-learning (ISL) in facilitating undergraduates' exploration of their conceptions of self (i.e., self-exploration). Conception of self refers to the use of values to define one's role in a social/cultural group or organization and in society, and to determine current actions and future…

LA SAFE and Isle de Jean Charles: Regional Adaptation and Community Resettlement Planning

NASA Astrophysics Data System (ADS)

Sanders, M.

2017-12-01

LA SAFE, or Louisiana's Strategic Adaptations for Future Environments, is a strategic framework for community development utilizing future projections of coastal land loss and flood risk as a determining factor in regional growth management and local planning initiatives along a 10, 25, and 50 year timeline. LA SAFE utilizes the input of passionate local citizen leaders and organizations committed to enabling community members to take proactive steps towards mitigating risk and increasing resilience against coastal issues. The project aims to acknowledge that adaptation and restoration must go hand-in-hand with addressing community growth and contraction, as well as realizing Louisiana's most vulnerable coastal communities will need to contemplate resettlement over the next 50 years. The project's outlook is to become a global leader for adaptation and cultural design and restoration. Connecting a global interest with the project and offering extensive ways for people to learn about the issues and get involved will provide an immense amount of support necessary for future coastal environments around the world. This presentation will focus on the output of a year-long planning effort across a six-parish target area encompassing several vulnerable coastal Louisiana locales. The Resettlement of Isle de Jean Charles is a federally-funded and first-of-its kind initiative marking Louisiana's first attempt to relocate a vulnerable coastal community at-scale and as a group. Due to a myriad of environmental factors, the Island has experienced 98 percent land loss since 1955, leading to many of the Island's historical inhabitants to retreat to higher, drier landscapes. In moving the community at-scale, the project seeks to inject new life into the community and its residents in relocating the community to higher, safer ground, while also developing the new community in such a way that it maximizes economic development, job training, and educational opportunities and can be a locale that is not only a model for future resettlement projects, but also attracts new and former residents of the Isle de Jean Charles community. This presentation will recap planning work completed to date, as well as provide a highlight of how the project is developing as a scalable, replicable model.

Phylogenetic analysis and antifouling potentials of culturable fungi in mangrove sediments from Techeng Isle, China.

PubMed

Zhang, Xiao-Yong; Fu, Wen; Chen, Xiao; Yan, Mu-Ting; Huang, Xian-De; Bao, Jie

2018-06-09

To search for more microbial resources for screening environment-friendly antifoulants, we investigated the phylogenetic diversity and antifouling potentials of culturable fungi in mangrove sediments from Techeng Isle, China. A total of 176 isolates belonging to 57 fungal taxa were recovered and identified. The high levels of diversity and abundance of mangrove fungi from Techeng Isle were in accordance with previous studies on fungi from other mangrove ecosystems. Fifteen of the 176 isolates demonstrated high divergence (87-93%) from the known fungal taxa in GenBank. Moreover, 26 isolates recorded in mangrove ecosystems for the first time. These results suggested that mangrove sediments from Techeng Isle harbored some new fungal communities compared with other mangrove ecosystems. The antifouling activity of 57 representative isolates (belonging to 57 different fungal taxa) was tested against three marine bacteria (Loktanella hongkongensis, Micrococcus luteus and Pseudoalteromonas piscida) and two marine macrofoulers (bryozoan Bugula neritina and barnacle Balanus amphitrite). Approximately 40% of the tested isolates displayed distinct antifouling activity. Furthermore, 17 fungal isolates were found to display strong or a wide spectrum of antifouling activity in this study, suggesting that these isolates deserve further study as potential sources of novel antifouling metabolites. To our knowledge, this is the first report on the investigation of the phylogenetic diversity and antifouling potential of culturable fungi in mangrove sediments from Techeng Isle, China. These results contribute to our knowledge of mangrove fungi and further increases the pool of fungi available for natural bioactive product screening.

A positive feedback regulation of ISL-1 in DLBCL but not in pancreatic β-cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Qiao, E-mail: zhangqiao200824@126.com; Yang, Zhe, E-mail: zheyang@bjmu.edu.cn; Wang, Weiping, E-mail: wwp@bjmu.edu.cn

2014-07-04

Highlights: • ISL-1 is highly expressed in human pancreatic β-cells and DLBCL. • ISL-1 accelerates the tumorigenesis of DLBCL in vivo. • c-Myc positively regulates ISL-1 expression in DLBCL but not in pancreatic β-cells. • ISL-1 and c-Myc forms an ISL-1/c-Myc transcriptional complex only in DLBCL. • Positive feedback regulation of ISL-1 does not exist in normal pancreatic β-cell. - Abstract: Insulin enhancer binding protein-1 (ISL-1), a LIM-homeodomain transcription factor, has been reported to play essential roles in promoting adult pancreatic β-cells proliferation. Recent studies indicate that ISL-1 may also involve in the occurrence of a variety of tumors. However,more » whether ISL-1 has any functional effect on tumorigenesis, and what are the differences on ISL-1 function in distinct conditions, are completely unknown. In this study, we found that ISL-1 was highly expressed in human pancreatic β-cells, as well as in diffuse large B cell lymphoma (DLBCL), but to a much less extent in other normal tissues or tumor specimens. Further study revealed that ISL-1 promoted the proliferation of pancreatic β-cells and DLBCL cells, and also accelerated the tumorigenesis of DLBCL in vivo. We also found that ISL-1 could activate c-Myc transcription not only in pancreatic β-cells but also in DLBCL cells. However, a cell-specific feedback regulation was detectable only in DLBCL cells. This auto-regulatory loop was established by the interaction of ISL-1 and c-Myc to form an ISL-1/c-Myc transcriptional complex, and synergistically to promote ISL-1 transcription through binding on the ISL-1 promoter. Taken together, our results demonstrate a positive feedback regulation of ISL-1 in DLBCL but not in pancreatic β-cells, which might result in the functional diversities of ISL-1 in different physiological and pathological processes.« less

Isl-1 down-regulates DRG cell proliferation during chicken embryo development.

PubMed

Chen, Dawei; Wang, Guoxin; Luo, Haoshu; Liu, Jiali; Cui, Sheng

2010-01-01

Protein Isl-1 RNA interference and over expression in early chicken embryo dorsal root ganglia (DRG) were used to investigate the function of Isl-1 in DRG cell proliferation. Isl-1 targeted shRNA expression vector and Isl-1 over-expression vector were transfected into chicken embryo DRG by in ovo electroporation. Then, the DRG proliferation rate was detected by BrdU immunohistochemistry. The rate of DRG cell proliferation increased after Isl-1 knock-down and decreased after Isl-1 over-expression. In this study, we found that Isl-1 negatively modulates DRG cell proliferation.

Isl1 Is required for multiple aspects of motor neuron development

PubMed Central

Liang, Xingqun; Song, Mi-Ryoung; Xu, ZengGuang; Lanuza, Guillermo M.; Liu, Yali; Zhuang, Tao; Chen, Yihan; Pfaff, Samuel L.; Evans, Sylvia M.; Sun, Yunfu

2011-01-01

The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in multiple organs and plays essential roles during embryogenesis. Isl1 is required for the survival and specification of spinal cord motor neurons. Due to early embryonic lethality and loss of motor neurons, the role of Isl1 in other aspects of motor neuron development remains unclear. In this study, we generated Isl1 mutant mouse lines expressing graded doses of Isl1. Our study has revealed essential roles of Isl1 in multiple aspects of motor neuron development, including motor neuron cell body localization, motor column formation and axon growth. In addition, Isl1 is required for survival of cranial ganglia neurons. PMID:21569850

Intercultural Education and Communication in Second Language Interactions

ERIC Educational Resources Information Center

Baraldi, Claudio

2012-01-01

This article analyses intercultural education outcomes produced in the setting of teaching Italian as a second language (ISL) in an Italian school. Intercultural education is produced in interactions which are based on specific cultural presuppositions, i.e. expectations regarding learning, role hierarchy and evaluation of student performances.…

Isl1 is required for multiple aspects of motor neuron development.

PubMed

Liang, Xingqun; Song, Mi-Ryoung; Xu, ZengGuang; Lanuza, Guillermo M; Liu, Yali; Zhuang, Tao; Chen, Yihan; Pfaff, Samuel L; Evans, Sylvia M; Sun, Yunfu

2011-07-01

The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in multiple organs and plays essential roles during embryogenesis. Isl1 is required for the survival and specification of spinal cord motor neurons. Due to early embryonic lethality and loss of motor neurons, the role of Isl1 in other aspects of motor neuron development remains unclear. In this study, we generated Isl1 mutant mouse lines expressing graded doses of Isl1. Our study has revealed essential roles of Isl1 in multiple aspects of motor neuron development, including motor neuron cell body localization, motor column formation and axon growth. In addition, Isl1 is required for survival of cranial ganglia neurons. Copyright © 2011 Elsevier Inc. All rights reserved.

Microwave vs optical crosslink study

NASA Technical Reports Server (NTRS)

Kwong, Paulman W.; Bruno, Ronald C.; Marshalek, Robert G.

1992-01-01

The intersatellite links (ISL's) at geostationary orbit is currently a missing link in commercial satellite services. Prior studies have found that potential application of ISL's to domestic, regional, and global satellites will provide more cost-effective services than the non-ISL's systems (i.e., multiple-hop systems). In addition, ISL's can improve and expand the existing satellite services in several aspects. For example, ISL's can conserve the scarce spectrum allocated for fixed satellite services (FSS) by avoiding multiple hopping of the relay stations. ISL's can also conserve prime orbit slot by effectively expanding the geostationary arc. As a result of the coverage extension by using ISL's more users will have direct access to the satellite network, thus providing reduced signal propagation delay and improved signal quality. Given the potential benefits of ISL's system, it is of interest to determine the appropriate implementations for some potential ISL architectures. Summary of the selected ISL network architecture as supplied by NASA are listed. The projected high data rate requirements (greater than 400 Mbps) suggest that high frequency RF or optical implementations are natural approaches. Both RF and optical systems have their own merits and weaknesses which make the choice between them dependent on the specific application. Due to its relatively mature technology base, the implementation risk associated with RF (at least 32 GHz) is lower than that of the optical ISL's. However, the relatively large antenna size required by RF ISL's payload may cause real-estate problems on the host spacecraft. In addition, because of the frequency sharing (for duplex multiple channels communications) within the limited bandwidth allocated, RF ISL's are more susceptible to inter-system and inter-channel interferences. On the other hand, optical ISL's can offer interference-free transmission and compact sized payload. However, the extremely narrow beam widths (on the order of 10 micro-rad) associated with optical ISL's impose very stringent pointing, acquisition, and tracking requirements on the system. Even if the RF and optical systems are considered separately, questions still remain as to selection of RF frequency, direct versus coherent optical detection, etc. in implementing an ISL for a particular network architecture. These and other issues are studied.

Single Event Effects and Total Dose Testing of the Intersil ISL 70003SEH Integrated Point of Load Converter

NASA Astrophysics Data System (ADS)

van Vonno, N. W.; White, J. D.; Pearce, L. G.; Thomson, E. J.; Gill, J. S.; Mansilla, O. E.

2014-08-01

Single-event transient (SET) phenomena in power management applications has evolved into a key issue, particularly in point of load (POL) buck regulators, as the loads driven by these devices are sensitive to even short-term overvoltage conditions. We preface this paper by a discussion of earlier destructive and nondestructive SEE testing of Intersil integrated point of load regulators, with emphasis on SET phenomena and some of the lessons learned in this work. We then report recent results of SET and destructive SEE testing of the ISL70003SEH POL converter, together with a brief discussion of the part's electrical and radiation hardness specifications. We conclude with a brief overview of low and high dose rate total dose testing of the part.

78 FR 11094 - Drawbridge Operation Regulation; James River, Between Isle of Wight and Newport News, VA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-15

... Operation Regulation; James River, Between Isle of Wight and Newport News, VA AGENCY: Coast Guard, DHS... River, mile 5.0, between Isle of Wight and Newport News, VA. This deviation is necessary to facilitate... Isle of Isle and Newport News, VA opens on signal. The James River Bridge has vertical clearances in...

LIM homeobox transcription factor Isl1 is required for melatonin synthesis in the pig pineal gland.

PubMed

Zhang, Jinglin; Qiu, Jingtao; Zhou, Yewen; Wang, Yue; Li, Hongjiao; Zhang, Taojie; Jiang, Ying; Gou, Kemian; Cui, Sheng

2018-02-26

Melatonin is a key hormone that regulates circadian rhythms, metabolism, and reproduction. However, the mechanisms of melatonin synthesis and secretion have not been fully defined. The purpose of this study was to investigate the functions of the LIM homeobox transcription factor Isl1 in regulating melatonin synthesis and secretion in porcine pineal gland. We found that Isl1 is highly expressed in the melatonin-producing cells in the porcine pineal gland. Further functional studies demonstrate that Isl1 knockdown in cultured primary porcine pinealocytes results in the decline of melatonin and arylalkylamine N-acetyltransferase (AANAT) mRNA levels by 29.2% and 72.2%, respectively, whereas Isl1 overexpression raised by 1.3-fold and 2.7-fold. In addition, the enhancing effect of norepinephrine (NE) on melatonin synthesis was abolished by Isl1 knockdown. The in vivo intracerebroventricular NE injections upregulate Isl1 mRNA and protein levels by about threefold and 4.5-fold in the porcine pineal gland. We then examined the changes in Isl1 expression in the pineal gland and global melatonin levels throughout the day. The results show that Isl1 protein level at 24:00 is 2.5-fold higher than that at 12:00, which is parallel to melatonin levels. We further found that Isl1 increases the activity of AANAT promoter, and the effect of NE on Isl1 expression was blocked by an ERK inhibitor. Collectively, the results presented here demonstrate that Isl1 positively modulates melatonin synthesis by targeting AANAT, via the ERK signaling pathway of NE. These suggest that Isl1 plays important roles in maintaining the daily circadian rhythm. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Implicit learning of sequential bias in a guessing task: failure to demonstrate effects of dopamine administration and paranormal belief.

PubMed

Palmer, John; Mohr, Christine; Krummenacher, Peter; Brugger, Peter

2007-06-01

Previous research suggests that implicit sequence learning (ISL) is superior for believers in the paranormal and individuals with increased cerebral dopamine. Thirty-five healthy participants performed feedback-guided anticipations of four arrow directions. A 100-trial random sequence preceded two 100-trial biased sequences in which visual targets (arrows) on trial t tended to be displaced 90 degrees clockwise (CW) or counter-clockwise (CCW) from those on t - 1. ISL was defined as a positive change during the course of the biased run in the difference between pro-bias and counter-bias responses. It was hypothesized that this difference would be greater for believers in the paranormal than for skeptics, for those who received dopamine than for those who received placebo, and for believers who received dopamine than for the other groups. None of the hypotheses were supported by the data. It is suggested that a simple binary guessing task with a focus on prediction accuracy during early trials should be considered for future explorations.

Intersatellite Link (ISL) application to commercial communications satellites. Volume 2: Technical final report

NASA Technical Reports Server (NTRS)

Young, S. Lee

1987-01-01

Intersatellite Link (ISL) applications can improve and expand communication satellite services in a number of ways. As the demand for orbital slots within prime regions of the geostationary arc increases, attention is being focused on ISLs as a method to utilize this resource more efficiently and circumvent saturation. Various GEO-to-GEO applications were determined that provide potential benefits over existing communication systems. A set of criteria was developed to assess the potential applications. Intersatellite link models, network system architectures, and payload configurations were developed. For each of the chosen ISL applications, ISL versus non-ISL satellite systems architectures were derived. Both microwave and optical ISL implementation approaches were evaluated for payload sizing and cost analysis. The technological availability for ISL implementations was assessed. Critical subsystems technology areas were identified, and an estamate of the schedule and cost to advance the technology to the requiered state of readiness was made.

Intersatellite Link (ISL) application to commercial communications satellites. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

Young, S. Lee

1987-01-01

Based on a comprehensive evaluation of the fundamental Intersatellite Link (ISL) systems characteristics, potential applications of ISLs to domestic, regional, and global commercial satellite communications were identified, and their cost-effectiveness and other systems benefits quantified wherever possible. Implementation scenarios for the cost-effective communications satellite systems employing ISLs were developed for the first launch in 1993 to 1994 and widespread use of ISLs in the early 2000's. Critical technology requirements for both the microwave (60 GHz) and optical (0.85 micron) ISL implementations were identified, and their technology development programs, including schedule and cost estimates, were derived.

Isoliquiritigenin exhibits anti-proliferative properties in the pituitary independent of estrogen receptor function

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weis, Karen E.; Raetzman, Lori T., E-mail: raetzma

The plant flavonoid isoliquiritigenin (ISL) is a botanical estrogen widely taken as an herbal supplement to ease the symptoms of menopause. ISL has been also shown to have anti-tumor properties in a number of cancer cell backgrounds. However, the effects of ISL on normal cells are less well known and virtually unstudied in the context of the pituitary gland. We have established a pituitary explant culture model to screen chemical agents for gene expression changes within the pituitary gland during a period of active proliferation and differentiation. Using this whole-organ culture system we found ISL to be weakly estrogenic basedmore » on its ability to induce Cckar mRNA expression, an estrogen receptor (ER) mediated gene. Using a range of ISL from 200 nM to 200 μM, we discovered that ISL promoted cell proliferation at a low concentration, yet potently inhibited proliferation at the highest concentration. ICI 182,780 failed to antagonize ISL's repression of pituitary cell proliferation, indicating the effect is independent of ER signaling. Coincident with a decrease in proliferating cells, we observed down-regulation of transcript for cyclin D2 and E2 and a strong induction of mRNA and protein for the cyclin dependent kinase inhibitor Cdkn1a (p21). Importantly, high dose ISL did not alter the balance of progenitor vs. differentiated cell types within the pituitary explants and they seemed otherwise healthy; however, TUNEL staining revealed an increase in apoptotic cell death in ISL treated cultures. Our results merit further examination of ISL as an anti-tumor agent in the pituitary gland. - Highlights: • Isoliquiritigenin possesses weak estrogenic activity based on induction of Cckar. • ISL can be anti-proliferative in pituitary explants without altering cell lineages. • Anti-proliferative behavior of ISL is not estrogen receptor mediated. • ISL induces p21 expression leading to cell cycle arrest and apoptosis.« less

Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE{sub 2} and IL-6

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, Haixia; Zhang, Xinhua; Chen, Xuewei

M2 macrophage polarization is implicated in colorectal cancer development. Isoliquiritigenin (ISL), a flavonoid from licorice, has been reported to prevent azoxymethane (AOM) induced colon carcinogenesis in animal models. Here, in a mouse model of colitis-associated tumorigenesis induced by AOM/dextran sodium sulfate (DSS), we investigated the chemopreventive effects of ISL and its mechanisms of action. Mice were treated with AOM/DSS and randomized to receive either vehicle or ISL (3, 15 and 75 mg/kg). Tumor load, histology, immunohistochemistry, and gene and protein expressions were determined. Intragastric administration of ISL for 12 weeks significantly decreased colon cancer incidence, multiplicity and tumor size bymore » 60%, 55.4% and 42.6%, respectively. Moreover, ISL inhibited M2 macrophage polarization. Such changes were accompanied by downregulation of PGE{sub 2} and IL-6 signaling. Importantly, depletion of macrophages by clodronate (Clod) or zoledronic acid (ZA) reversed the effects of ISL. In parallel, in vitro studies also demonstrated that ISL limited the M2 polarization of RAW264.7 cells and mouse peritoneal macrophages with concomitant inactivation of PGE{sub 2}/PPARδ and IL-6/STAT3 signaling. Conversely, exogenous addition of PGE{sub 2} or IL-6, or overexpression of constitutively active STAT3 reversed ISL-mediated inhibition of M2 macrophage polarization. In summary, dietary flavonoid ISL effectively inhibits colitis-associated tumorigenesis through hampering M2 macrophage polarization mediated by the interplay between PGE{sub 2} and IL-6. Thus, inhibition of M2 macrophage polarization is likely to represent a promising strategy for chemoprevention of colorectal cancer. - Highlights: • Isoliquiritigenin (ISL) prevents colitis-associated tumorigenesis. • ISL inhibits M2 macrophage polarization in vivo and in vitro. • ISL inhibits PGE{sub 2} and IL-6 signaling in colitis-associated tumorigenesis. • ISL may be an attractive candidate agent for chemoprevention of colorectal cancer.« less

77 FR 35903 - Safety Zone, Atlantic Intracoastal Waterway; Emerald Isle, NC

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-15

... 1625-AA00 Safety Zone, Atlantic Intracoastal Waterway; Emerald Isle, NC AGENCY: Coast Guard, DHS... zone on the waters of the Atlantic Intracoastal Waterway at Emerald Isle, North Carolina. The safety... Intracoastal Waterway, mile 226, at Emerald Isle, North Carolina. [[Page 35904

Single Sex Math Classes: What and for Whom? One School's Experiences.

ERIC Educational Resources Information Center

Durost, Richard A.

1996-01-01

Presque Isle (Maine) High School has offered a section of all-girls algebra for seven years. The intent was to narrow the gap between 11th-grade boys' and girls' math achievement scores and create a more comfortable learning atmosphere for girls. The achievement score gap has decreased from 72 to 16 points. (MLH)

75 FR 65514 - Columbia Forest Products, Inc., Presque Isle Division, Presque Isle, ME; Notice of Affirmative...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-25

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-70,110] Columbia Forest Products, Inc., Presque Isle Division, Presque Isle, ME; Notice of Affirmative Determination Regarding Application for Reconsideration By application dated February 16, 2010, workers requested administrative...

77 FR 44463 - Safety Zone, Atlantic Intracoastal Waterway; Emerald Isle, NC

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-30

... 1625-AA00 Safety Zone, Atlantic Intracoastal Waterway; Emerald Isle, NC AGENCY: Coast Guard, DHS... waters of the Atlantic Intracoastal Waterway at Emerald Isle, North Carolina. The safety zone is... Bridge crossing the Atlantic Intracoastal Waterway, mile 226, at Emerald Isle, North Carolina. The safety...

77 FR 64906 - Safety Zone, Atlantic Intracoastal Waterway; Emerald Isle, NC

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-24

... 1625-AA00 Safety Zone, Atlantic Intracoastal Waterway; Emerald Isle, NC AGENCY: Coast Guard, DHS... zone on the waters of the Atlantic Intracoastal Waterway at Emerald Isle, North Carolina. The safety... NC 58 Fixed Bridge crossing the Atlantic Intracoastal Waterway, mile 226, at Emerald Isle, North...

77 FR 57063 - Safety Zone, Atlantic Intracoastal Waterway; Emerald Isle, NC

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-17

... 1625-AA00 Safety Zone, Atlantic Intracoastal Waterway; Emerald Isle, NC AGENCY: Coast Guard, DHS... zone on the waters of the Atlantic Intracoastal Waterway at Emerald Isle, North Carolina. The safety... NC 58 Fixed Bridge crossing the Atlantic Intracoastal Waterway, mile 226, at Emerald Isle, North...

Evidence of Atlantic salmon Salmo salar fry movement between fresh water and a brackish environment.

PubMed

Taal, I; Rohtla, M; Saks, L; Svirgsden, R; Kesler, M; Matetski, L; Vetemaa, M

2017-08-01

This study reports descent of Atlantic salmon Salmo salar fry from their natal streams to brackish waters of the Baltic Sea and their use of this environment as an alternative rearing habitat before ascending back to freshwater streams. To the authors' knowledge, residency in a brackish environment has not previously been demonstrated in S. salar fry. Recruitment success and evolutionary significance of this alternative life-history strategy are presently not known. © 2017 The Fisheries Society of the British Isles.

27 CFR 9.51 - Isle St. George.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Isle St. George. 9.51... St. George. (a) Name. The name of the viticultural area described in this section is “Isle St. George.” (b) Approved maps. The approved map for determining the boundary of the Isle St. George viticultural...

Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation.

PubMed

Wang, Neng; Wang, Zhiyu; Wang, Yu; Xie, Xiaoming; Shen, Jiangang; Peng, Cheng; You, Jieshu; Peng, Fu; Tang, Hailin; Guan, Xinyuan; Chen, Jianping

2015-01-01

Breast cancer stem cells (CSCs) are considered as the root of mammary tumorigenesis. Previous studies have demonstrated that ISL efficiently limited the activities of breast CSCs. However, the cancer prevention activities of ISL and its precise molecular mechanisms remain largely unknown. Here, we report a novel function of ISL as a natural demethylation agent targeting WIF1 to prevent breast cancer. ISL administration suppressed in vivo breast cancer initiation and progression, accompanied by reduced CSC-like populations. A global gene expression profile assay further identified WIF1 as the main response gene of ISL treatment, accompanied by the simultaneous downregulation of β-catenin signaling and G0/G1 phase arrest in breast CSCs. In addition, WIF1 inhibition significantly relieved the CSC-limiting effects of ISL and methylation analysis further revealed that ISL enhanced WIF1 gene expression via promoting the demethylation of its promoter, which was closely correlated with the inhibition of DNMT1 methyltransferase. Molecular docking analysis finally revealed that ISL could stably dock into the catalytic domain of DNMT1. Taken together, our findings not only provide preclinical evidence to demonstrate the use of ISL as a dietary supplement to inhibit mammary carcinogenesis but also shed novel light on WIF1 as an epigenetic target for breast cancer prevention.

Investigation of Breakwater Stability at Presque Isle Peninsula Erie, Pennsylvania

DTIC Science & Technology

1989-05-01

PRESQUE ISLE PENINSULA AD-A208 528 ERIE , PENNSYLVANIA by Peter J. Grace...STABILITY AT PRESQUE ISLE PENINSULA, ERIE . PENNSYLVANIA PART I: INTRODUCTION The Prototype 1. Harbor facilities at Erie , Pennsylvania , are protected...at Presque Isle Beaches, Erie , Pennsylvania ," Technical Report HL-83-15, US Army Engineer Waterways Experiment Station, Vicksburg, MS. Stevens, J.

75 FR 36292 - Safety Zone; Bay Swim III, Presque Isle Bay, Erie, PA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-25

... of Presque Isle Bay, Lake Erie, near Erie, Pennsylvania between 9 a.m. to 11 a.m. on June 26, 2010.... The safety zone will encompass specified waters of Presque Isle Bay, Erie, Pennsylvania starting at...-AA00 Safety Zone; Bay Swim III, Presque Isle Bay, Erie, PA AGENCY: Coast Guard, DHS. ACTION: Temporary...

Presque Isle Peninsula, Erie, Pennsylvania. Volume I. Main Report. Revised.

DTIC Science & Technology

1980-11-01

PRESQUE ISLE PENINSULA, ERIE , PENNSYLVANIA . Memorandum includimg~nviron- 1.6... Pennsylvania THE SECRETARY OF THE ARMY 1. I submit for transmission to Congress my report on Presque Isle Peninsula, Erie , Pennsylvania . It is...advanced engineering and design of the project for beach erosion control for Presque Isle Peninsula at Erie , Pennsylvania . 2. The District and

76 FR 15366 - Additional Designation of Entities Pursuant to Executive Order 13382

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-21

..., Manning House, 21 Bucks Road, Douglas IM1 3DA, Man, Isle of; Business Registration Document 003648V (Man..., Man, Isle of; Business Registration Document 003645V (Man, Isle of) issued 2 Mar 2009 [NPWMD] Neuman...] Springthorpe Limited, Manning House, 21 Bucks Road, Douglas IM1 3DA, Man, Isle of; Business Registration...

Forest Resources of Isle Royale National Park 2010

Treesearch

Wilfred J. Previant; Linda M. Nagel; Scott A. Pugh; Christopher W. Woodall

2012-01-01

This publication provides a baseline overview of forest resources for Isle Royale National Park (Isle Royale) using data from the Forest Inventory and Analysis (FIA) Program of the U.S. Department of Agriculture, Forest Service. The availability of permanent FIA plots allows for the first-ever comparison of Isle Royale's forest conditions (2006-2010) to reserved...

"The Isle Is Full of Noises": Using Wiki Software to Establish a Discourse Community in a Shakespeare Classroom

ERIC Educational Resources Information Center

Farabaugh, Robin

2007-01-01

For the last four semesters my courses in Shakespeare have used QwikiWiki and MediaWiki, two versions of the wiki software, for writing exercises and directed reflection on language--including both by the students about Shakespeare's language, and by the teacher/researcher regarding the students' performance in "Writing to Learn". In experimenting…

Detached Breakwaters for Shore Protection.

DTIC Science & Technology

1986-01-01

Presque Isle , Pennsylvania 23. At Presque Isle on Lake Erie , a segmented system of over 50 de- tached breakwaters is planned...Erosion at Presque Isle , Erie , Pennsylvania ," CERC Technical Report HL-83-15, US Army Engineer Waterways Experiment Station, Vicksburg, Miss. Seelig...by Seabergh (1983) on Presque Isle Pen- insula, Erie , Pennsylvania , which is a recurved sandspit protecting Erie Har- bor. The peninsula has

Do future commercial broadband communication satellites really need laser-communication intersatellite links (ISLs)?

NASA Astrophysics Data System (ADS)

Freidell, James E.

1997-04-01

Large commercial satellite programs requiring ISLs are growing in number and maturing. An important segment of the commercial satellite market, and its ISL needs, is discussed in the paper. ISL value will increase as long-haul terrestrial backbones become increasingly congested. Providing interregional and intercontinental connectivity via ISL presents far lower cost and fewer problems than relying on terrestrial fiber-optic networks. To demonstrate this, a new metric is proposed which allows 'apples-to- apples' cost/performance comparisons between laser communications in GEO, LEO, and terrestrial fiber-optics. ISL requirements in to the next decade are predicted >= 50-100 Gb/s full duplex. Many attitudinal changes must be embraced among those who choose to focus on this new commercial business. Foremost among these is a preponderance to delivering fully acceptable hardware fast and at low cost, as opposed to merely designing such. Considerable attention must be given business considerations foreign to professionals who have spent time in the government or government contracting sectors. Successful ISL customers will come to recognize that ISLs are not commodity products. Failure to embrace these attitudes will nonetheless constitute decision to which the commercial market, and particularly the financial market, will appropriately respond.

The individual supported living (ISL) manual: a planning and review instrument for individual supported living arrangements for adults with intellectual and developmental disabilities.

PubMed

Cocks, E; Thoresen, S; Williamson, M; Boaden, R

2014-07-01

Following the closure of large residential facilities over the past several decades, emphasis on community living for adults with developmental disabilities has strengthened. However, the concept of community living is ambiguous. The term is often associated with congregation of people with disabilities in ordinary houses 'in' the community. Group homes, the most common contemporary formal expression of 'community living', may use ordinary houses and accommodate a small number of residents comparable to a large family. Individual supported living (ISL) arrangements around a single person with a disability using person-centred principles are occurring with increasing frequency. The ISL manual was developed over 4 years in two sequential research projects to produce a quality framework articulating ISL and operationalising the framework into a review and planning instrument for ISL arrangements. The ISL manual was developed in three stages and overseen by a reference group of key stakeholders purposively recruited as well-versed in ISL. The first stage operationalised the quality framework over two half-day workshops with a group of key informants. Participants identified indicators and sources of evidence for each attribute of the quality framework. The quality framework, indicators, and sources of evidence were compiled into an initial evaluation instrument of nine themes consisting of 27 attributes. This was piloted in two rounds to enhance the utility of the instrument and develop the final manual which contained eight themes and 21 attributes. A comprehensive literature search was carried out to identify relevant empirical ISL studies. The literature search identified four empirical studies that incorporated ISL over the preceding 3 years. A previous literature search from the first research project that produced the quality framework spanned 27 years and identified five empirical studies. We concluded that the empirical base for developing evidence for the nature and outcomes of ISL arrangements was sparse. The ISL manual and scoring booklet developed in the current research project includes six illustrative case studies of ISL, instructions for potential users to review living arrangements or set up a new arrangement, and the review framework consisting of descriptions of themes and attributes, indicators, and sources of evidence. The dearth of empirical studies of ISL arrangements for people with developmental disabilities, despite increased policy emphasis on individualised options, underscores the importance of planning and review tools to promote quality outcomes. The ISL manual can assist adults with developmental disabilities, families, carers, and service providers to plan and review ISL arrangements. Further research will enhance the properties of this instrument and establish the relationship between quality of ISL arrangements and outcomes such as quality of life, and participation and inclusion. © 2013 MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley & Sons Ltd.

Report of Accomplishments under the Airport Improvement Program.

DTIC Science & Technology

1982-09-30

Acquire snow removal equipment; conduct City of Portland feasibility study. Portland International (PRIMARY) Presque Isle 01 $ 15,840 Airport Master Plan...update to terminal City of Presque Isle area plan). Northern Maine Regional (PRIMARY) Presque Isle 02 $ 118,869 Rehabilitate terminal access road...City of Presque Isle Northern Maine Regional (PRIMARY) Rockland 01 $ 40,252 Airport Master Plan (update). Knox County Knox County Regional (COMMERCIAL

Microwave intersatellite links for communications satellites

NASA Technical Reports Server (NTRS)

Welti, G. R.

1982-01-01

Applications and interface requirements for intersatellite links (ISLs) between commercial communications satellites are reviewed, ranging from ISLs between widely separated satellites to ISLs between clustered satellites. On-board processing architectures for ISLs employing a variety of modulation schemes are described. These schemes include FM remodulation and QPSK regeneration in combination with switching and buffering. The various architectures are compared in terms of complexity, required performance, antenna size, mass, and power.

Sims to Teen Second Life: Transition of the SimSavvy Girls to Tech Savvy Isle

ERIC Educational Resources Information Center

Johnson, Barbara Z.; King, Elizabeth; Hayes, Elisabeth

2008-01-01

In its second year, the Tech Savvy Girls Project adopted "Teen Second Life" as a platform for interest-driven learning and designed projects and objects around themes important to them and their futures as technology-using, creative people. By using the building tools in an open-ended virtual world, they were able to pursue interests common to…

Voluntary emergence and water detection in a newly recognized amphibious fish.

PubMed

Magellan, K

2015-06-01

Galaxias 'nebula', a small fish which has adaptations for air-breathing but is not known to be amphibious, voluntarily emerged from water and, in an unfamiliar environment, moved preferentially towards an alternative water source. Nebula may thus be considered one of the few truly amphibious fishes, and their ability to detect water provides a selective advantage which aids their survival in unpredictable natural environments. © 2015 The Fisheries Society of the British Isles.

Annotated Bibliography for Lake Erie. Volume II. Chemical,

DTIC Science & Technology

1974-10-01

on the ecology of Presque Isle Bay, Erie , Pennsylvania . Environmental Sciences, Inc. Pittsburg, Pa. 232 p. Water quality in Presque Isle Bay is...Gottschall, Russell Y. 1930. Preliminary report on the phytoplankton and pollution in Presque Isle Bay, Lake Erie . Proc. Pa. Acad. Sci. 4:69-74. The...waters of Presque Isle Bay and vicinity are contaminated with sewage from the city of Erie . No evidence to date has been found of anaerobic respiration or

Endocrine Secretory Reserve and Proinsulin Processing in Recipients of Islet of Langerhans Versus Whole Pancreas Transplants

PubMed Central

Elkhafif, Nabeel M.; Borot, Sophie; Morel, Philippe; Demuylder-Mischler, Sandrine; Giovannoni, Laurianne; Toso, Christian; Bosco, Domenico; Berney, Thierry

2013-01-01

OBJECTIVE β-Cells have demonstrated altered proinsulin processing after islet transplantation. We compare β-cell metabolic responses and proinsulin processing in pancreas and islet transplant recipients with respect to healthy control subjects. RESEARCH DESIGN AND METHODS We studied 15 islet and 32 pancreas transplant recipients. Islet subjects were subdivided into insulin-requiring (IR-ISL, n = 6) and insulin-independent (II-ISL, n = 9) groups. Ten healthy subjects served as control subjects. Subjects were administered an intravenous arginine stimulation test, and insulin, C-peptide, total proinsulin, intact proinsulin, and proinsulin fragment levels were determined from serum samples. Acute insulin response (AIR) and proinsulin processing rates were calculated. RESULTS We found that basal insulin and C-peptide levels were higher in the pancreas group than in all other groups. II-ISL patients had basal insulin and C-peptide levels similar to healthy control subjects. The IR-ISL group had significantly lower AIRs than all other groups. Basal processing rates were higher in the pancreas and II-ISL groups than in healthy control subjects and the IR-ISL group. After arginine stimulation, all groups had elevated processing rates, with the exception of the IR-ISL group. CONCLUSIONS Our data suggest that II-ISL transplant recipients can maintain basal metabolic parameters similar to healthy control subjects at the cost of a higher rate of proinsulin processing. IR-ISL transplant recipients, on the other hand, demonstrate both lower insulin response and lower basal rates of proinsulin processing even after arginine stimulation. PMID:24041681

Environmental impact of the MV CITA on the foreshore of Porth Hellick, Isles of Scilly.

PubMed

Smith, Nicola A

2004-12-01

The grounding of the container feeder vessel MV CITA on Newfoundland Rocks, Isles of Scilly, had an effect on the surrounding biota and benthic environment. Included in the CITA's cargo were five 40 ft containers holding pallets of polyester film used in the production of audio and visual recording tapes. The wreckage presented a minor but potentially chronic source of pollution through the delayed release of polythene film, which was left on the seabed as it was considered insufficiently valuable to warrant salvage. The polythene disintegrated and was washed upon the foreshore of Porth Hellick in minute shreds. The adjacent foreshore and two control sites within the islands were analysed using a 5-strand line and vegetation survey with 10 random quadrats within each line to determine the environmental impact of the polythene.

Intersatellite link application to commercial communications satellites

NASA Technical Reports Server (NTRS)

Lee, Young S.; Atia, Ali E.; Ponchak, Denise S.

1988-01-01

The fundamental characteristics of intersatellite link (ISL) systems, and their application to domestic, regional, and global satellite communications, are described. The quantitative advantages of using ISLs to improve orbit utilization, spectrum occupancy, transmission delay (compared to multi-hop links), coverage, and connectivity, and to reduce the number of earth station antennas, are also presented. Cost-effectiveness and other systems benefits of using ISLs are identified, and the technical and systems planning aspects of ISL systems implementation are addressed.

Isoliquiritigenin protects against sepsis-induced lung and liver injury by reducing inflammatory responses.

PubMed

Chen, Xiong; Cai, Xueding; Le, Rongrong; Zhang, Man; Gu, Xuemei; Shen, Feixia; Hong, Guangliang; Chen, Zimiao

2018-02-05

Sepsis, one of the most fatal diseases worldwide, often leads to multiple organ failure, mainly due to uncontrolled inflammatory responses. Despite accumulating knowledge obtained in recent years, effective drugs to treat sepsis in the clinic are still urgently needed. Isoliquiritigenin (ISL), a chalcone compound, has been reported to exert anti-inflammatory properties. However, little is known about the effects of ISL on sepsis and its related complications. In this study, we investigated the potential protective effects of ISL on lipopolysaccharide (LPS)-induced injuries and identified the mechanisms underlying these effects. ISL inhibited inflammatory cytokine expression in mouse primary peritoneal macrophages (MPMs) exposed to LPS. In an acute lung injury (ALI) mouse model, ISL prevented LPS-induced structural damage and inflammatory cell infiltration. Additionally, pretreatment with ISL attenuated sepsis-induced lung and liver injury, accompanied by a reduction in inflammatory responses. Moreover, these protective effects were mediated by the nuclear factor kappa B (NF-κB) pathway-mediated inhibition of inflammatory responses in vitro and in vivo. Our study suggests that ISL may be a potential therapeutic agent for sepsis-induced injuries. Copyright © 2017. Published by Elsevier Inc.

27 CFR 9.51 - Isle St. George.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Isle St. George. 9.51 Section 9.51 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.51 Isle...

27 CFR 9.51 - Isle St. George.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Isle St. George. 9.51 Section 9.51 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.51 Isle...

27 CFR 9.51 - Isle St. George.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Isle St. George. 9.51 Section 9.51 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.51 Isle...

Genetic variability among lake whitefish from Isle Royale and the Upper Great Lakes

USGS Publications Warehouse

Stott, Wendylee; Todd, Thomas N.; Kallemeyn, Larry

2004-01-01

The coregonine fishes from Isle Royale National Park represent a unique group that has escaped the successional changes observed elsewhere in North America. Analysis of microsatellite DNA loci revealed significant genetic differences among samples of lake whitefish (Coregonus clupeaformis) from Isle Royale, Lake Superior, and Lake Huron. The amount of genetic variation observed is consistent with that seen in other studies of whitefishes from North America. The lake whitefish from Isle Royale had previously been assigned sub-species status, but no evidence was found to support this. The effects of common ancestry and demographics both play a role in determining the relatedness of the populations. As with other fish species from Isle Royale and the upper Great Lakes, the lake whitefish have their origins in the Mississippi refugium.

ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells

PubMed Central

Pan, Ling; Deng, Min; Xie, Xiaoling; Gan, Lin

2009-01-01

SUMMARY LIM-homeodomain (HD) and POU-HD transcription factors play critical roles in neurogenesis. However, it remains largely unknown how they cooperate in this process and what downstream target genes they regulate. Here we show that ISL1, a LIM-HD protein, is co-expressed with BRN3B, a POU-HD factor, in nascent, post-mitotic retinal ganglion cells (RGCs). Similar to the Brn3b-null retinas, retina-specific deletion of Isl1 results in the apoptosis of a majority of RGCs and in RGC axon guidance defects. The Isl1 and Brn3b double null mice display more severe retinal abnormalities with a near complete loss of RGCs, indicating the synergistic functions of these two factors. Furthermore, we show that both Isl1 and Brn3b function downstream of Math5 to regulate the expression of a common set of RGC-specific genes. Whole retina chromatin immunoprecipitation and in vitro transactivation assays reveal that ISL1 and BRN3B concurrently bind to and synergistically regulate the expression of a common set of RGC-specific genes. Thus, our results uncover a novel regulatory mechanism of BRN3B and ISL1 in RGC differentiation. PMID:18434421

Expression of the LIM-Homeodomain Protein Isl1 in the Developing and Mature Mouse Retina

PubMed Central

Elshatory, Yasser; Deng, Min; Xie, Xiaoling; Gan, Lin

2010-01-01

The mammalian retina is comprised of six major neuronal cell types and is subdivided into more morphological and physiological subtypes. The transcriptional machinery underlying these subtype fate choices is largely unknown. The LIM-homeodomain protein, Isl1, plays an essential role in central nervous system (CNS) differentiation but its relationship to retinal neurogenesis remains unknown. We report here its dynamic spatiotemporal expression in the mouse retina. Among bipolar interneurons, Isl1 expression commences at postnatal day (P)5 and is later restricted to ON-bipolar cells. The intensity of Isl1 expression is found to segregate the pool of ON-bipolar cells into rod and ON-cone bipolar cells with higher expression in rod bipolar cells. As bipolar cell development proceeds from P5–10 the colocalization of Isl1 and the pan-bipolar cell marker Chx10 reveals the organization of ON-center bipolar cell nuclei to the upper portion of the inner nuclear layer. Further, whereas Isl1 is predominantly a ganglion cell marker prior to embryonic day (E)15.5, at E15.5 and later its expression in nonganglion cells expands. We demonstrate that these Isl1-positive, nonganglion cells acquire the expression of amacrine cell markers embryonically, likely representing nascent cholinergic amacrine cells. Taken together, Isl1 is expressed during the maturation of and is later maintained in retinal ganglion cells and subtypes of amacrine and bipolar cells where it may function in the maintenance of these cells into adulthood. J. Comp. Neurol. 503: 182–197, 2007. PMID:17480014

A wind tunnel study of flows over idealised urban surfaces with roughness sublayer corrections

NASA Astrophysics Data System (ADS)

Ho, Yat-Kiu; Liu, Chun-Ho

2017-10-01

Dynamics in the roughness (RSLs) and inertial (ISLs) sublayers in the turbulent boundary layers (TBLs) over idealised urban surfaces are investigated analytically and experimentally. In this paper, we derive an analytical solution to the mean velocity profile, which is a continuous function applicable to both RSL and ISL, over rough surfaces in isothermal conditions. Afterwards, a modified mixing-length model for RSL/ISL transport is developed that elucidates how surface roughness affects the turbulence motions. A series of wind tunnel experiments are conducted to measure the vertical profiles of mean and fluctuating velocities, together with momentum flux over various configurations of surface-mounted ribs in cross flows using hot-wire anemometry (HWA). The analytical solution agrees well with the wind tunnel result that improves the estimate to mean velocity profile over urban surfaces and TBL dynamics as well. The thicknesses of RSL and ISL are calculated by monitoring the convergence/divergence between the temporally averaged and spatio-temporally averaged profiles of momentum flux. It is found that the height of RSL/ISL interface is a function of surface roughness. Examining the direct, physical influence of roughness elements on near-surface RSL flows reveals that the TBL flows over rough surfaces exhibit turbulence motions of two different length scales which are functions of the RSL and ISL structure. Conclusively, given a TBL, the rougher the surface, the higher is the RSL intruding upward that would thinner the ISL up to 50 %. Therefore, the conventional ISL log-law approximation to TBL flows over urban surfaces should be applied with caution.

Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution

PubMed Central

Kim, Namhee; Park, Chungoo; Jeong, Yongsu; Song, Mi-Ryoung

2015-01-01

Functional diversification of motor neurons has occurred in order to selectively control the movements of different body parts including head, trunk and limbs. Here we report that transcription of Isl1, a major gene necessary for motor neuron identity, is controlled by two enhancers, CREST1 (E1) and CREST2 (E2) that allow selective gene expression of Isl1 in motor neurons. Introduction of GFP reporters into the chick neural tube revealed that E1 is active in hindbrain motor neurons and spinal cord motor neurons, whereas E2 is active in the lateral motor column (LMC) of the spinal cord, which controls the limb muscles. Genome-wide ChIP-Seq analysis combined with reporter assays showed that Phox2 and the Isl1-Lhx3 complex bind to E1 and drive hindbrain and spinal cord-specific expression of Isl1, respectively. Interestingly, Lhx3 alone was sufficient to activate E1, and this may contribute to the initiation of Isl1 expression when progenitors have just developed into motor neurons. E2 was induced by onecut 1 (OC-1) factor that permits Isl1 expression in LMCm neurons. Interestingly, the core region of E1 has been conserved in evolution, even in the lamprey, a jawless vertebrate with primitive motor neurons. All E1 sequences from lamprey to mouse responded equally well to Phox2a and the Isl1-Lhx3 complex. Conversely, E2, the enhancer for limb-innervating motor neurons, was only found in tetrapod animals. This suggests that evolutionarily-conserved enhancers permit the diversification of motor neurons. PMID:26447474

Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution.

PubMed

Kim, Namhee; Park, Chungoo; Jeong, Yongsu; Song, Mi-Ryoung

2015-10-01

Functional diversification of motor neurons has occurred in order to selectively control the movements of different body parts including head, trunk and limbs. Here we report that transcription of Isl1, a major gene necessary for motor neuron identity, is controlled by two enhancers, CREST1 (E1) and CREST2 (E2) that allow selective gene expression of Isl1 in motor neurons. Introduction of GFP reporters into the chick neural tube revealed that E1 is active in hindbrain motor neurons and spinal cord motor neurons, whereas E2 is active in the lateral motor column (LMC) of the spinal cord, which controls the limb muscles. Genome-wide ChIP-Seq analysis combined with reporter assays showed that Phox2 and the Isl1-Lhx3 complex bind to E1 and drive hindbrain and spinal cord-specific expression of Isl1, respectively. Interestingly, Lhx3 alone was sufficient to activate E1, and this may contribute to the initiation of Isl1 expression when progenitors have just developed into motor neurons. E2 was induced by onecut 1 (OC-1) factor that permits Isl1 expression in LMCm neurons. Interestingly, the core region of E1 has been conserved in evolution, even in the lamprey, a jawless vertebrate with primitive motor neurons. All E1 sequences from lamprey to mouse responded equally well to Phox2a and the Isl1-Lhx3 complex. Conversely, E2, the enhancer for limb-innervating motor neurons, was only found in tetrapod animals. This suggests that evolutionarily-conserved enhancers permit the diversification of motor neurons.

33 CFR 100.912 - Detroit Bell Isle Grand Prix, Detroit, MI.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Detroit Bell Isle Grand Prix, Detroit, MI. 100.912 Section 100.912 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.912 Detroit Bell Isle Grand...

36 CFR 7.38 - Isle Royale National Park.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a) Aircraft...

36 CFR 7.38 - Isle Royale National Park.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a) Aircraft...

36 CFR 7.38 - Isle Royale National Park.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a) Aircraft...

36 CFR 7.38 - Isle Royale National Park.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a) Aircraft...

36 CFR 7.38 - Isle Royale National Park.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a) Aircraft...

33 CFR 110.179 - Skidaway River, Isle of Hope, Ga.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Skidaway River, Isle of Hope, Ga. 110.179 Section 110.179 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.179 Skidaway River, Isle of Hope, Ga. (a) The...

Conservation genetics of the endangered Isle Royale gray wolf

USGS Publications Warehouse

Wayne, R.K.; Lehman, N.; Girman, D.; Gogan, P.J.P.; Gilbert, D.A.; Hansen, K.; Peterson, R.O.; Seal, U.S.; Eisenhawer, Andrew; Mech, L.D.; Krumenaker, R.J.

1991-01-01

The small group of wolves on Isle Royale has been studied for over three decades as a model of the relationship between large carnivores and their prey. During the last ten years the population declined from 50 individuals to as few as 12 individuals. The causes of this decline may be food shortages, disease, or reduced genetic variability. We address the issues of genetic variability and relationships of Isle Royale wolves using allozyme electrophoresis, mtDNA restriction-site analysis, and multilocus hypervariable minisatellite DNA analysis (genetic fingerprinting). Our results indicate that approximately 50% of the allozyme heterozygosity has been lost in the island population, a decline similar to that expected if no immigration had occurred from the mainland. The genetic fingerprinting data indicate that the seven sampled Isle Royale wolves are as similar as captive populations of siblings. Surprisingly, the Isle Royale wolves have an mtDNA genotype that is very rare on the mainland, being found in only one of 144 mainland wolves. This suggests that the remaining Isle Royale wolves are probably derived from a single female founder.

Erosion and deterioration of the Isles Dernieres Barrier Island Arc, Louisiana, U.S.A.: 1853 to 1988

USGS Publications Warehouse

McBride, Randolph A.; Penland, Shea; Jaffe, Bruce E.; Williams, S. Jeffress; Sallenger, Asbury H.; Westphal, Karen A.

1989-01-01

Using cartographic and aerial photography data from the years 1853, 1890, 1934, 1956, 1978, 1984, and 1988, shoreline change maps of the Isles Dernieres barrier island arc were constructed. These data were accurately superimposed, using a computer mapping system, which removed projection, datum, scale, and other cartographic inconsistencies. Linear, areal, and perimeter measurements indicate that the Isles Dernieres are suffering rapid rates of coastal erosion, land loss, and breakup. Bayside and gulfside erosion, in combination with sediment shortage and subsidence, have caused the Isles Dernieres to narrow through time. In addition, the core of the barrier island arc does not migrate landward and instead, breaks up in place as a result of inlet breaching and development. This is in contrast to other models of landward barrier island migration during transgression. If these trends continue, the Isles Dernieres will likely evolve into a subaqueous inner-shelf shoal by the early 21st century. Loss of the Isles Dernieres barrier island arc will severely impact the Terrebonne parish estuary, resulting in decreased environmental quality and increased public risk from storms and hurricanes.

Time synchronization of new-generation BDS satellites using inter-satellite link measurements

NASA Astrophysics Data System (ADS)

Pan, Junyang; Hu, Xiaogong; Zhou, Shanshi; Tang, Chengpan; Guo, Rui; Zhu, Lingfeng; Tang, Guifeng; Hu, Guangming

2018-01-01

Autonomous satellite navigation is based on the ability of a Global Navigation Satellite System (GNSS), such as Beidou, to estimate orbits and clock parameters onboard satellites using Inter-Satellite Link (ISL) measurements instead of tracking data from a ground monitoring network. This paper focuses on the time synchronization of new-generation Beidou Navigation Satellite System (BDS) satellites equipped with an ISL payload. Two modes of Ka-band ISL measurements, Time Division Multiple Access (TDMA) mode and the continuous link mode, were used onboard these BDS satellites. Using a mathematical formulation for each measurement mode along with a derivation of the satellite clock offsets, geometric ranges from the dual one-way measurements were introduced. Then, pseudoranges and clock offsets were evaluated for the new-generation BDS satellites. The evaluation shows that the ranging accuracies of TDMA ISL and the continuous link are approximately 4 cm and 1 cm (root mean square, RMS), respectively. Both lead to ISL clock offset residuals of less than 0.3 ns (RMS). For further validation, time synchronization between these satellites to a ground control station keeping the systematic time in BDT was conducted using L-band Two-way Satellite Time Frequency Transfer (TWSTFT). System errors in the ISL measurements were calibrated by comparing the derived clock offsets with the TWSTFT. The standard deviations of the estimated ISL system errors are less than 0.3 ns, and the calibrated ISL clock parameters are consistent with that of the L-band TWSTFT. For the regional BDS network, the addition of ISL measurements for medium orbit (MEO) BDS satellites increased the clock tracking coverage by more than 40% for each orbital revolution. As a result, the clock predicting error for the satellite M1S was improved from 3.59 to 0.86 ns (RMS), and the predicting error of the satellite M2S was improved from 1.94 to 0.57 ns (RMS), which is a significant improvement by a factor of 3-4.

Stage 2 Report for Reformulation Phase I General Design Memorandum, Cleveland Harbor, Ohio. Volume II. Appendices. Revision.

DTIC Science & Technology

1983-02-01

Harbor Lighthouse Pointe Betsie Light Station Pennsylvania Port Sanilac Light Station Presque Isle Light Station Presque Isle Light Rock of Ages Light...Marquette, MI : 0.6 : 0.4 0.1 0 : 0 : 0 : 0 : : 0 : 0 : - Presque Isle , MI: 2.4 1.4 1.4 1.3 : 1.4 1.5 1.0 : 0.9 : 0.4 1.3 8.6 Silver Bay, MN 5.0 : 4.1...conditions. The long distance sourcing patterns of Outer Harbor iron ore (Silver Bay, Duluth-Superior, Escanaba, Presque Isle ) also favors the use of

Geological Character and Mineral Resources of South Central Lake Erie.

DTIC Science & Technology

1982-10-01

Presque Isle Peninsula, Erie , Pennsylvania , being conducted by the U.S. Army Engineer District...the Pennsylvania shoreline. Because of its position and morphology, Presque Isle acts as a natural offshore breakwater for Erie Harbor, blocking the...Research Center, Fort Belvoir, Va. (in preparation, 1982). U.S. ARMY ENGINEER DISTRICT, BUFFALO, " Presque Isle Peninsula, Erie , Pennsylvania ,"

The case for watchful waiting with Isle Royale's wolf population

USGS Publications Warehouse

Mech, L. David

2013-01-01

In "Should Isle Royale Wolves be Reintroduced? A Case Study on Wilderness Management in a Changing World," Vucetich et al. concluded with the hope that their analysis “motivates broader discussion that deepens understanding of the specifics on Isle Royale and the underlying principles” (2012: 137). This article represents an attempt to continue that discussion.

75 FR 51379 - Safety Zone; Celebrate Erie, Presque Isle Bay, Erie, PA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-20

... display. DATES: This rule is effective from 9:30 p.m. until 10:30 p.m. on August 22, 2010. ADDRESSES...: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on Presque Isle Bay... Presque Isle Bay in Erie, PA during the Celebrate Erie fireworks display, August 22, 2010. This temporary...

An instrumented spatial linkage for measuring knee joint kinematics.

PubMed

Rosvold, Joshua M; Atarod, Mohammad; Frank, Cyril B; Shrive, Nigel G

2016-01-01

In this study, the design and development of a highly accurate instrumented spatial linkage (ISL) for kinematic analysis of the ovine stifle joint is described. The ovine knee is a promising biomechanical model of the human knee joint. The ISL consists of six digital rotational encoders providing six degrees of freedom (6-DOF) to its motion. The ISL makes use of the complete and parametrically continuous (CPC) kinematic modeling method to describe the kinematic relationship between encoder readings and the relative positions and orientation of its two ends. The CPC method is useful when calibrating the ISL, because a small change in parameters corresponds to a small change in calculated positions and orientations and thus a smaller optimization error, compared to other kinematic models. The ISL is attached rigidly to the femur and the tibia for motion capture, and the CPC kinematic model is then employed to transform the angle sensor readings to relative motion of the two ends of the linkage, and thereby, the stifle joint motion. The positional accuracy for ISL after calibration and optimization was 0.3±0.2mm (mean +/- standard deviation). The ISL was also evaluated dynamically to ensure that accurate results were maintained, and achieved an accuracy of 0.1mm. Compared to the traditional motion capture methods, this system provides increased accuracy, reduced processing time, and ease of use. Future work will be on the application of the ISL to the ovine gait and determination of in vivo joint motions and tissue loads. Accurate measurement of knee joint kinematics is essential in understanding injury mechanisms and development of potential preventive or treatment strategies. Copyright © 2015 Elsevier B.V. All rights reserved.

Erosion and deterioration of Isles Dernieres Barrier Island arc, Louisiana: 1842-1988

DOE Office of Scientific and Technical Information (OSTI.GOV)

McBride, R.A.; Westphal, K.; Penland, S.

1989-09-01

The Isles Dernieres barrier island arc is the most rapidly eroding coastline in the US. Located on the Mississippi River delta plain in Terrebonne Parish, Louisiana, the Isles Dernieres consists of four smaller islands in a 32-km long chain. From west to east, these islands are known as Raccoon Island, Whiskey Island, Trinity Island, and East Island. The barrier island arc is separated from the mainland by Caillou Bay, Boca Caillou, and Lake Pelto lagoonal systems. The abandonment and transgression of the Bayou Petit Caillou delta (part of the larger Lafourche delta complex) over the last 600 years, along withmore » sea level rise, repeated storm impacts, and rapid shoreface erosion, have led to the formation of the Isles Dernieres. Continued transgressive submergence combined with a diminishing sediment supply are driving the extreme coastal erosion found in the Isles Dernieres.« less

Ranging Consistency Based on Ranging-Compensated Temperature-Sensing Sensor for Inter-Satellite Link of Navigation Constellation

PubMed Central

Meng, Zhijun; Yang, Jun; Guo, Xiye; Zhou, Yongbin

2017-01-01

Global Navigation Satellite System performance can be significantly enhanced by introducing inter-satellite links (ISLs) in navigation constellation. The improvement in position, velocity, and time accuracy as well as the realization of autonomous functions requires ISL distance measurement data as the original input. To build a high-performance ISL, the ranging consistency among navigation satellites is an urgent problem to be solved. In this study, we focus on the variation in the ranging delay caused by the sensitivity of the ISL payload equipment to the ambient temperature in space and propose a simple and low-power temperature-sensing ranging compensation sensor suitable for onboard equipment. The experimental results show that, after the temperature-sensing ranging compensation of the ISL payload equipment, the ranging consistency becomes less than 0.2 ns when the temperature change is 90 °C. PMID:28608809

Cattaraugus Creek Harbor, New York General Design Memorandum. Phase II. (Detailed Design). Volume II. Appendix E. Littoral Processes and Sedimentation in the Cattaraugus Embayment, New York. Appendix F. Sediment Transport in Cattaraugus Creek.

DTIC Science & Technology

1976-03-01

beaches than any other part of the southeastern shoreline of Lake Erie . It is the only major sand accumulation zone with the exception of Presque Isle , in...52 20. Photographs of zonal site #10. 54 21. Photograph and map of zonal site #11, Presque Isle , Pa. 57 F22. Photographs and beach profiles at zonal...site #11. 59 23. Photograph of zonal site #12, the recurved spit area on Presque Isle , Pa. 62 24. Block diagram of recurved spit area of Presque Isle

Optical Studies of CaS:Eu, Sm Infrared Stimulable Phosphors

NASA Astrophysics Data System (ADS)

Tamura, Yasuaki; Shibukawa, Atsushi

1993-07-01

The photoluminescence (PL) and infrared stimulated luminescence (ISL) spectra of CaS:Eu,Sm infrared stimulable phosphors (ISPs) are studied. In addition, the concentration dependence of ISL intensity is examined. Sm3+- and Eu2+-related structures are found in both the PL excitation and emission spectra. Two types of Sm3+ are found, one of which exhibits strong emission at around 650 nm and the other, weak emission compared to the other emissions at around 565 nm and 605 nm. These are assigned to an asymmetric and a symmetric site, respectively. ISL excitation spectra coincide with the Eu2+ 4f7 to 4f65d1 and 4f66s1 transitions and range from 220 to 650 nm. ISL emission spectra coincide with the Eu2+ 4f65d1 to 4f7 transition and range from 550 to 750 nm. ISL stimulation spectra range from 0.8 μm to 1.7 μm and are thought to indicate the Sm2+ ion transition from 4f6 to 4f55d1. The maximum ISL intensity is obtained from a sample with Eu and Sm concentrations of 500 and 130 ppm, respectively.

Autophagy participates in isoliquiritigenin-induced melanin degradation in human epidermal keratinocytes through PI3K/AKT/mTOR signaling.

PubMed

Yang, Zhibo; Zeng, Biyun; Pan, Yi; Huang, Pan; Wang, Chang

2018-01-01

Melanin is the pigment responsible for the color of human skin and hair. Melanin serves as a double-edge sword which can exert both protective and spot-causing effects on skin. Although melanin has an important role in protecting the skin against UV damage, an excessive or uneven melanin production can lead to the formation of freckles and age spots. Isoliquiritigenin (ISL) has been reported to inhibit melanin synthesis; however, its role in melanin degradation remains unclear. In the present study, we evaluated the detailed function of ISL in melanin degradation in human epidermal keratinocytes. Since autophagy has been reported to be related to melanin degradation, we also examined the activation of autophagy by ISL treatment in keratinocytes by measurement of autophagy-related proteins, ATG7, LC3 and p62. Moreover, si-ATG7-induced ATG7 knockdown and autophagy inhibitor 3-MA decreased LC3 II protein levels and increased PMEL17, p62 and melanin levels in HaCaT cells, which could be partially reversed by ISL treatment, indicating that autophagy participated in melanin degradation. The decreased p-AKT and p-mTOR proteins upon ISL treatment indicated the involvement of PI3K/AKT/mTOR signaling in ISL-induced melanin degradation. Taken together, we demonstrated that autophagy participates in ISL-induced melanin degradation in human epidermal keratinocytes through PI3K/AKT/mTOR signaling. Copyright © 2017. Published by Elsevier Masson SAS.

Beach Nourishment Techniques. Report 3. Typical U.S. Beach Nourishment Projects Using Offshore Sand Deposits.

DTIC Science & Technology

1981-05-01

Cooperative Beach Erosion Control Project at Presque Isle Peninsula, Erie , Pennsylvania ," Buffalo, N. Y. U. S. Army Engineer District, Charleston. 1963 (Mar...104 Presque Isle , Pa .. .. ..................... 109 REFERENCES .. ............................ 115 2A BEACH NOURISHMENT...RIVER COUNTY, FL T PRESQUE ISLE . PA Figure 1. Beach fill projects location map ...../ ...... studies have been authorized, or which are publicly owned

33 CFR 334.40 - Atlantic Ocean in vicinity of Duck Island, Maine, Isles of Shoals; naval aircraft bombing target...

Code of Federal Regulations, 2012 CFR

2012-07-01

... Duck Island, Maine, Isles of Shoals; naval aircraft bombing target area. 334.40 Section 334.40... AND RESTRICTED AREA REGULATIONS § 334.40 Atlantic Ocean in vicinity of Duck Island, Maine, Isles of... yards having its center on Shag Rock in the vicinity of Duck Island at latitude 43°00′12″, longitude 70...

33 CFR 334.40 - Atlantic Ocean in vicinity of Duck Island, Maine, Isles of Shoals; naval aircraft bombing target...

Code of Federal Regulations, 2014 CFR

2014-07-01

... Duck Island, Maine, Isles of Shoals; naval aircraft bombing target area. 334.40 Section 334.40... AND RESTRICTED AREA REGULATIONS § 334.40 Atlantic Ocean in vicinity of Duck Island, Maine, Isles of... yards having its center on Shag Rock in the vicinity of Duck Island at latitude 43°00′12″, longitude 70...

33 CFR 334.40 - Atlantic Ocean in vicinity of Duck Island, Maine, Isles of Shoals; naval aircraft bombing target...

Code of Federal Regulations, 2013 CFR

2013-07-01

... Duck Island, Maine, Isles of Shoals; naval aircraft bombing target area. 334.40 Section 334.40... AND RESTRICTED AREA REGULATIONS § 334.40 Atlantic Ocean in vicinity of Duck Island, Maine, Isles of... yards having its center on Shag Rock in the vicinity of Duck Island at latitude 43°00′12″, longitude 70...

33 CFR 334.40 - Atlantic Ocean in vicinity of Duck Island, Maine, Isles of Shoals; naval aircraft bombing target...

Code of Federal Regulations, 2011 CFR

2011-07-01

... Duck Island, Maine, Isles of Shoals; naval aircraft bombing target area. 334.40 Section 334.40... AND RESTRICTED AREA REGULATIONS § 334.40 Atlantic Ocean in vicinity of Duck Island, Maine, Isles of... yards having its center on Shag Rock in the vicinity of Duck Island at latitude 43°00′12″, longitude 70...

33 CFR 334.40 - Atlantic Ocean in vicinity of Duck Island, Maine, Isles of Shoals; naval aircraft bombing target...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Duck Island, Maine, Isles of Shoals; naval aircraft bombing target area. 334.40 Section 334.40... AND RESTRICTED AREA REGULATIONS § 334.40 Atlantic Ocean in vicinity of Duck Island, Maine, Isles of... yards having its center on Shag Rock in the vicinity of Duck Island at latitude 43°00′12″, longitude 70...

76 FR 52266 - Safety Zone; Coast Guard Exercise, Detroit River, Ambassador Bridge to the Western Tip of Belle Isle

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-22

...-AA00 Safety Zone; Coast Guard Exercise, Detroit River, Ambassador Bridge to the Western Tip of Belle... Bridge to the western tip of Belle Isle. This safety zone is intended to restrict vessels from portions.... on August 23, 2011. The safety zone will begin at Ambassador Bridge to the western tip of Belle Isle...

The geologic story of Isle Royale National Park

USGS Publications Warehouse

Huber, N. King

1975-01-01

Isle Royale is an outstanding example of relatively undisturbed northwoods lake wilderness. But more than simple preservation of such an environment is involved in its inclusion in our National Park System. Its isolation from the mainland provides an almost untouched laboratory for research in the natural sciences, especially those studies whose very nature depends upon such isolation. One excellent example of such research is the intensive study of the predator-prey relationship of the timber wolf and moose, long sponsored by the National Park Service and Purdue University. In probably no other place in North America are the necessary ecological conditions for such a study so admirably fulfilled as on Isle Royale. The development of a natural laboratory with such conditions is ultimately dependent upon geologic processes and events that although not unique in themselves, produced in their interplay a unique result, the island archipelago as we know it today, with its hills and valleys, swamps and bogs the ecological framework of the plant and animal world. Even the most casual visitor can hardly fail to be struck by the fiordlike nature of many of the bays, the chains of fringing islands, the ridge-and-valley topography, and the linear nature of all these features. The distinctive topography of the archipelago is, of course, only the latest manifestation of geologic processes in operation since time immemorial. Fragments of geologic history going back over a billion years can be read from the rocks of the island, and with additional data from other parts of the Lake Superior region, we can fill in some of the story of Isle Royale. After more than a hundred years of study by man, the story is still incomplete. But then, geologic stories are seldom complete, and what we do know allows a deeper appreciation of one of our most naturally preserved parks and whets our curiosity about the missing fragments.

Erie Harbor, Pennsylvania, Channel Shoaling Analysis

DTIC Science & Technology

2011-07-01

Presque Isle is located on the southern shore of Lake Erie and shelters the federal harbor at Erie , Pennsylvania . The US Army...the evaluation of the shoaling and dredging of sediment materials from Erie Harbor as part of the Presque Isle , Pennsylvania 204 feasibility study...ERDC TR-11-4 1 1 Introduction Problem statement Presque Isle is located on the southern shore of Lake Erie , Pennsylvania at the city of Erie

History of the Coastal Engineering Research Center 1963-1983, Volume 1

DTIC Science & Technology

1991-01-01

jn the groin and sand replenishment projects at Newport Beach, California; Presque Isle Peninsu la on Lake Erie at Erie , Pennsyl - varua; and...of Environmental Resources in dune building field tests at Ludington State Park, Michigan, and Presque Isle State Park. Pennsylvania . After the...Shelf." 3 . Dennis W. Berg ... J- actor’> Affecting Beach Nourishmem Requirements. Presque Isle Peninsula, Erie , Pennsy lvania,’’ Great Lakes

Changes in Sea Levels around the British Isles Revisited (Invited)

NASA Astrophysics Data System (ADS)

Teferle, F. N.; Hansen, D. N.; Bingley, R. M.; Williams, S. D.; Woodworth, P. L.; Gehrels, W. R.; Bradley, S. L.; Stocchi, P.

2009-12-01

Recently a number of new and/or updated sources for estimates of vertical land movements for the British Isles have become available allowing the relative and average changes in sea levels for this region to be revisited. The geodetic data set stems from a combination of re-processed continuous Global Positioning System (GPS) measurements from stations in the British Isles and from a global reference frame network, and absolute gravity (AG) measurements from two stations in the British Isles. The geologic data set of late Holocene sea level indicators has recently been updated, now applying corrections for the 20th century sea level rise, syphoning effect and late Holocene global ice melt, and expanded to Northern Ireland and Ireland. Several new model predictions of the glacial isostatic adjustment (GIA) process active in this region form the modelling data set of vertical land movements for the British Isles. Correcting the updated revised local reference (RLR) trends from the Permanent Service for Mean Sea Level (PSMSL) with these vertical land movement data sets, regional and averaged changes in sea levels around the British Isles have been investigated. Special focus is thereby also given to the coastal areas that have recently been identified within the UK Climate Projections 2009.

Isoliquiritigenin-Induced Differentiation in Mouse Melanoma B16F0 Cell Line

PubMed Central

Chen, Xiaoyu; Zhang, Bo; Yuan, Xuan; Yang, Fan; Liu, Jinglei; Zhao, Hong; Liu, Liangliang; Wang, Yanming; Wang, Zhenhua; Zheng, Qiusheng

2012-01-01

The chemotherapeutical treatment is very limited for malignant melanoma, a highly lethal disease occurs globally. Natural products derived from traditional Chinese medicine licorice are attractive in quest new treatments due to their anti-tumor activities. A new dietary flavonoid isoliquiritigenin (ISL) were thus investigated to indentify its anti-melanoma activities on mouse melanoma B16F0 cells in present study. Using biochemical and free radical biological experiments in vitro, we identified the pro-differentiated profiles of ISL and evaluated the role of reactive oxygen species (ROS) during B16F0 cell differentiation. The data showed a strong dose-response relationship between ISL exposure and the characteristics of B16F0 differentiation in terms of morphology changes and melanogenesis. The accumulated intercellular ROS during exposure are necessary to support ISL-induced differentiation, which was proven by additional redox modulators. It was confirmed further by the relative activities of enzymes and genes modulated melanogenesis in ISL-treatments with or without ROS modulators. The tumorigenicity of ISL-treated cells was limited significantly by using the colony formation assay in vitro and an animal model assay in vivo respectively. Our research demonstrated that isoliquiritigenin is a differentiation-inducing agent, and its mechanisms involve ROS accumulation facilitating melanogenesis. PMID:23304254

Isoliquiritigenin-induced differentiation in mouse melanoma B16F0 cell line.

PubMed

Chen, Xiaoyu; Zhang, Bo; Yuan, Xuan; Yang, Fan; Liu, Jinglei; Zhao, Hong; Liu, Liangliang; Wang, Yanming; Wang, Zhenhua; Zheng, Qiusheng

2012-01-01

The chemotherapeutical treatment is very limited for malignant melanoma, a highly lethal disease occurs globally. Natural products derived from traditional Chinese medicine licorice are attractive in quest new treatments due to their anti-tumor activities. A new dietary flavonoid isoliquiritigenin (ISL) were thus investigated to indentify its anti-melanoma activities on mouse melanoma B16F0 cells in present study. Using biochemical and free radical biological experiments in vitro, we identified the pro-differentiated profiles of ISL and evaluated the role of reactive oxygen species (ROS) during B16F0 cell differentiation. The data showed a strong dose-response relationship between ISL exposure and the characteristics of B16F0 differentiation in terms of morphology changes and melanogenesis. The accumulated intercellular ROS during exposure are necessary to support ISL-induced differentiation, which was proven by additional redox modulators. It was confirmed further by the relative activities of enzymes and genes modulated melanogenesis in ISL-treatments with or without ROS modulators. The tumorigenicity of ISL-treated cells was limited significantly by using the colony formation assay in vitro and an animal model assay in vivo respectively. Our research demonstrated that isoliquiritigenin is a differentiation-inducing agent, and its mechanisms involve ROS accumulation facilitating melanogenesis.

Optical studies of CaS:Eu,Sm infrared stimulable phosphors

NASA Astrophysics Data System (ADS)

Tamura, Yasuaki; Shibukawa, Atsushi

1993-07-01

The photoluminescence (PL) and infrared stimulated luminescence (ISL) spectra of CaS:Eu,Sm infrared stimulable phosphors (ISPs) are studied. In addition, the concentration dependence of ISL intensity is examined. Sm(3+) and Eu(2+) related structures are found in both the PL excitation and emission spectra. Two types of Sm(3+) are found, one of which exhibits strong emission at around 650 nm and the other weak emission compared to the other emissions at around 565 nm and 605 nm. These are assigned to an asymmetric and a symmetric site, respectively. ISL excitation spectra coincide with the Eu(2+) 4f(sup 7) to 4f(sup 6)5d(sup 1) and 4f(sup 6)6s(sup 1) transitions and range from 220 to 650 nm. ISL emission spectra coincide with the Eu(2+) 4f(sup 6)5d(sup 1) to 4f(sup 7) transition and range from 550 to 750 nm. ISL stimulation spectra range from 0.8 micron to 1.7 micron and are thought to indicate the Sm(2+) ion transition from 4f(sup 6) to 4f(sup 5)5d(sup 1). The maximum ISL intensity is obtained from a sample with Eu and Sm concentrations of 500 and 130 ppm, respectively.

Special challenges in the conservation of fishes and aquatic environments of South America.

PubMed

Costa, M F; Barletta, M

2016-07-01

In South America, the conservation of natural resources, particularly in relation to water and aquatic fauna, is an often-discussed issue. Unfortunately, there is still a large gap between thoughts and action. Scientists from different countries of the continent have however, produced a significant body of literature that should finally become the basis of emerging managerial models. © 2016 The Fisheries Society of the British Isles.

Design, calibration and validation of a novel 3D printed instrumented spatial linkage that measures changes in the rotational axes of the tibiofemoral joint.

PubMed

Bonny, Daniel P; Hull, M L; Howell, S M

2014-01-01

An accurate axis-finding technique is required to measure any changes from normal caused by total knee arthroplasty in the flexion-extension (F-E) and longitudinal rotation (LR) axes of the tibiofemoral joint. In a previous paper, we computationally determined how best to design and use an instrumented spatial linkage (ISL) to locate the F-E and LR axes such that rotational and translational errors were minimized. However, the ISL was not built and consequently was not calibrated; thus the errors in locating these axes were not quantified on an actual ISL. Moreover, previous methods to calibrate an ISL used calibration devices with accuracies that were either undocumented or insufficient for the device to serve as a gold-standard. Accordingly, the objectives were to (1) construct an ISL using the previously established guidelines,(2) calibrate the ISL using an improved method, and (3) quantify the error in measuring changes in the F-E and LR axes. A 3D printed ISL was constructed and calibrated using a coordinate measuring machine, which served as a gold standard. Validation was performed using a fixture that represented the tibiofemoral joint with an adjustable F-E axis and the errors in measuring changes to the positions and orientations of the F-E and LR axes were quantified. The resulting root mean squared errors (RMSEs) of the calibration residuals using the new calibration method were 0.24, 0.33, and 0.15 mm for the anterior-posterior, medial-lateral, and proximal-distal positions, respectively, and 0.11, 0.10, and 0.09 deg for varus-valgus, flexion-extension, and internal-external orientations, respectively. All RMSEs were below 0.29% of the respective full-scale range. When measuring changes to the F-E or LR axes, each orientation error was below 0.5 deg; when measuring changes in the F-E axis, each position error was below 1.0 mm. The largest position RMSE was when measuring a medial-lateral change in the LR axis (1.2 mm). Despite the large size of the ISL, these calibration residuals were better than those for previously published ISLs, particularly when measuring orientations, indicating that using a more accurate gold standard was beneficial in limiting the calibration residuals. The validation method demonstrated that this ISL is capable of accurately measuring clinically important changes (i.e. 1 mm and 1 deg) in the F-E and LR axes.

Annotated Bibliography for Lake Erie. Volume I. Biological,

DTIC Science & Technology

1974-10-01

varieties of naiades from I Lake Erie . Nautilus. 32(l):9-12. Three new varieties of naiades collected at Presque Isle , Pennsylvania are carefully...E. 1909. A botanical survey of Presque Isle , Erie County, Pennsylvania . Annals Carnegie Mus. Pittsburgh, Penn. Pub. 53. 5(l):2 9-421. This study...of vegetation on Presque Isle . (SM) 401. Jennings, Otto E. 1930. A survey of the phytoplankton at Erie , Pennsylvania . Science. 71(1848):560-61. A

Beach Erosional Hot Spots: Types, Causes, and Solutions

DTIC Science & Technology

2001-09-01

Pope, and McClung (1999) showed that variable erosion rates along a beach nourishment project on Presque Isle , Pennsylvania (Lake Erie ) were related to...and McClung, J. K. (1999). “Coastal response to a detached breakwater system: Presque Isle , Erie , PA, U.S.A,” Proc. Coastal Sediments ’99, ASCE...borrow pits located too close to shore at Grand Isle , LA. The resultant cuspate shoreline was subsequently predicted by refraction analysis

Disposal of Vessel Wastes: Shipboard and Shoreside Facilities. Phase 2. Graywater

DTIC Science & Technology

1979-07-01

Increase in Concentration Resulting from Daily Loadings and Vessel-Induced Mixing 45 3-7 Annual Loadings to Presque Isle - Marquette Harbor from...in port for 24 hours (Upper Lakes Reference Group, 1977a). Two harbors were considered for case studies. The first harbor, Presque Isle -Marquette...harbor. Presque Isle -Marquette The existing conditions of the harbor are considered to be of high quality with respect to coastal waters, the open waters

Operational Art in Pontiac’s War

DTIC Science & Technology

2015-05-23

and Fort Presque Isle lay along the supply route connecting Fort Pitt over land to Lake Erie further linking across the water to major forts through...expedition in early August. Traveling south along the coast of Lake Erie , Bradstreet first stopped at Presque Isle . Bradstreet was hesitant to initiate...destroyed Fort Presque Isle . The next stop was Sandusky Bay, where Dalyell took some men several miles inland to rout Huron warriors from the village of

Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zheng, Hao; Li, Ying; Wang, Yuzhong

Flavonoids exert extensive in vitro anti-invasive and in vivo anti-metastatic activities. Anoikis resistance occurs at multiple key stages of the metastatic cascade. Here, we demonstrate that isoliquiritigenin (ISL), a flavonoid from Glycyrrhiza glabra, inhibits human breast cancer metastasis by preventing anoikis resistance, migration and invasion through downregulating cyclooxygenase (COX)-2 and cytochrome P450 (CYP) 4A signaling. ISL induced anoikis in MDA-MB-231 and BT-549 human breast cancer cells as evidenced by flow cytometry and the detection of caspase cleavage. Moreover, ISL inhibited the mRNA expression of phospholipase A2, COX-2 and CYP 4A and decreased the secretion of prostaglandin E{sub 2} (PGE{sub 2})more » and 20-hydroxyeicosatetraenoic acid (20-HETE) in detached MDA-MB-231 cells. In addition, it decreased the levels of phospho-PI3K (Tyr{sup 458}), phospho-PDK (Ser{sup 241}) and phospho-Akt (Thr{sup 308}). Conversely, the exogenous addition of PGE{sub 2}, WIT003 (a 20-HETE analog) and an EP4 agonist (CAY10580) or overexpression of constitutively active Akt reversed ISL-induced anoikis. ISL exerted the in vitro anti-migratory and anti-invasive activities, whereas the addition of PGE{sub 2}, WIT003 and CAY10580 or overexpression of constitutively active Akt reversed the in vitro anti-migratory and anti-invasive activities of ISL in MDA-MB-231 cells. Notably, ISL inhibited the in vivo lung metastasis of MDA-MB-231 cells, together with decreased intratumoral levels of PGE{sub 2}, 20-HETE and phospho-Akt (Thr{sup 308}). In conclusion, ISL inhibits breast cancer metastasis by preventing anoikis resistance, migration and invasion via downregulating COX-2 and CYP 4A signaling. It suggests that ISL could be a promising multi-target agent for preventing breast cancer metastasis, and anoikis could represent a novel mechanism through which flavonoids may exert the anti-metastatic activities. - Highlights: • Isoliquiritigenin induces anoikis and suppresses metastasis in breast cancer. • COX-2 and CYP4A signaling plays crucial roles in isoliquiritigenin-induced anoikis. • PI3K/Akt deactivation is asssociated with isoliquiritigenin-induced anoikis. • Isoliquiritigenin is a promising multi-target agent for therapy of breast cancer.« less

Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood

PubMed Central

Nasif, Sofia; de Souza, Flavio S. J.; González, Laura E.; Yamashita, Miho; Orquera, Daniela P.; Rubinstein, Marcelo

2015-01-01

Food intake and body weight regulation depend on proper expression of the proopiomelanocortin gene (Pomc) in a group of neurons located in the mediobasal hypothalamus of all vertebrates. These neurons release POMC-encoded melanocortins, which are potent anorexigenic neuropeptides, and their absence from mice or humans leads to hyperphagia and severe obesity. Although the pathophysiology of hypothalamic POMC neurons is well understood, the genetic program that establishes the neuronal melanocortinergic phenotype and maintains a fully functional neuronal POMC phenotype throughout adulthood remains unknown. Here, we report that the early expression of the LIM-homeodomain transcription factor Islet 1 (ISL1) in the developing hypothalamus promotes the terminal differentiation of melanocortinergic neurons and is essential for hypothalamic Pomc expression since its initial onset and throughout the entire lifetime. We detected ISL1 in the prospective hypothalamus just before the onset of Pomc expression and, from then on, Pomc and Isl1 coexpress. ISL1 binds in vitro and in vivo to critical homeodomain binding DNA motifs present in the neuronal Pomc enhancers nPE1 and nPE2, and mutations of these sites completely disrupt the ability of these enhancers to drive reporter gene expression to hypothalamic POMC neurons in transgenic mice and zebrafish. ISL1 is necessary for hypothalamic Pomc expression during mouse and zebrafish embryogenesis. Furthermore, conditional Isl1 inactivation from POMC neurons impairs Pomc expression, leading to hyperphagia and obesity. Our results demonstrate that ISL1 specifies the identity of hypothalamic melanocortin neurons and is required for melanocortin-induced satiety and normal adiposity throughout the entire lifespan. PMID:25825735

iss012e15918

NASA Image and Video Library

2006-01-24

ISS012-E-15918 (24 Jan. 2006) --- Belle Isle and a portion of Newfoundland, Canada are featured in this image photographed by an Expedition 12 crew member on the International Space Station. Belle Isle (center) is surrounded by sea ice in this recent winter view. Belle Isle lies in the strait between the Island of Newfoundland and Labrador (the mainland portion of Canada’s province of Newfoundland). Small islands along the coast of Labrador appear in the top left corner. In this key location Belle Isle lies on the shortest shipping lanes between the Great Lakes and Europe, and also on the main north-south shipping route to Hudson Bay and the Northwest Territories. Snow and ice in this recent winter view obliterate the dozens of glacier-scoured lakes that dot the surface of the island. The single community of Belle Isle Landing on the southeast tip is equally hard to see. Ice patterns also show that the island lies at the meeting point of two sea currents. The Labrador Current flows from the northwest (top left), and a smaller current, driven by dominant westerly winds, flows from the southwest (lower left) out of the narrow Belle Isle Strait (out of frame lower left). Flow lines in sea ice indicate the sense of movement of the ice. Ice floes embedded in the Labrador Current appear in the upper part of the image as a relatively open pattern. Sea ice with a denser pattern enters from the lower left corner, banking against the west side of Belle Isle. Tendrils flow around capes at either end of the island, with an ice-free “shadow” on the opposite, downstream side. Eddies (center) in the ice patterns show where the currents interact, north and west of the island.

Comparative expression analysis of POU4F1, POU4F2 and ISL1 in developing mouse cochleovestibular ganglion neurons

PubMed Central

Deng, Min; Yang, Hua; Xie, Xiaoling; Liang, Guoqing; Gan, Lin

2014-01-01

POU-homeodomain and LIM-homeodomain transcription factors are expressed in developing projection neurons within retina, inner ear, dorsal root ganglion, and trigeminal ganglion, and play synergistic roles in their differentiation and survival. Here, using immunohistochemistry, we present a comparative analysis of the spatiotemporal expression pattern of POU4F1, POU4F2, and ISL1 during the development of cochleovestibular ganglion (CVG) neurons in mouse inner ear. At early stages, when otic neurons are first detected in the otic epithelium (OE) and migrate into periotic mesenchyme to form the CVG, POU4F1 and ISL1 are co-expressed in a majority of the delaminated CVG neurons, which are marked by NEUROD1 expression, but POU4F1 is absent in the otic epithelium. The onset of POU4F2 expression starts after that of POU4F1 and ISL1, and is observed in the NEUROD1-negative, post-mitotic CVG neurons. When the CVG neurons innervate the vestibular and cochlear sensory organs, the expression of POU4F1, POU4F2, and ISL1 continues in both vestibular and spiral ganglion cells. Later in development, POU4F1 expression becomes down-regulated in a majority of spiral ganglion (SG) neurons and more neurons express POU4F2 expression while ISL1 expression is maintained. The differential as well as overlapping expression of POU4F1, POU4F2, and ISL1 combined with previous studies suggests possible functional interaction and regulatory relationship of these transcription factors in the development of inner ear neurons. PMID:24709358

Unusual July 10, 1996, rock fall at Happy Isles, Yosemite National Park, California

USGS Publications Warehouse

Wieczorek, G.F.; Snyder, J.B.; Waitt, R.B.; Morrissey, M.M.; Uhrhammer, R.A.; Harp, E.L.; Norris, R.D.; Bursik, M.I.; Finewood, L.G.

2000-01-01

Effects of the July 10, 1996, rock fall at Happy Isles in Yosemite National Park, California, were unusual compared to most rock falls. Two main rock masses fell about 14 s apart from a 665-m-high cliff southeast of Glacier Point onto a talus slope above Happy Isles in the eastern part of Yosemite Valley. The two impacts were recorded by seismographs as much as 200 km away. Although the impact area of the rock falls was not particularly large, the falls generated an airblast and an abrasive dense sandy cloud that devastated a larger area downslope of the impact sites toward the Happy Isles Nature Center. Immediately downslope of the impacts, the airblast had velocities exceeding 110 m/s and toppled or snapped about 1000 trees. Even at distances of 0.5 km from impact, wind velocities snapped or toppled large trees, causing one fatality and several serious injuries beyond the Happy Isles Nature Center. A dense sandy cloud trailed the airblast and abraded fallen trunks and trees left standing. The Happy Isles rock fall is one of the few known worldwide to have generated an airblast and abrasive dense sandy cloud. The relatively high velocity of the rock fall at impact, estimated to be 110-120 m/s, influenced the severity and areal extent of the airblast at Happy Isles. Specific geologic and topographic conditions, typical of steep glaciated valleys and mountainous terrain, contributed to the rock-fall release and determined its travel path, resulting in a high velocity at impact that generated the devastating airblast and sandy cloud. The unusual effects of this rock fall emphasize the importance of considering collateral geologic hazards, such as airblasts from rock falls, in hazard assessment and planning development of mountainous areas.

Lake Erie Water Level Study. Appendix F. Environmental Effects.

DTIC Science & Technology

1981-07-01

were reevaluated with weight being placed on the most recent data. The wetland area in Pennsylvania was limited to that area on and around Presque Isle ...and East Harbor, Sandusky Bay, Northeast Yacht Club, Mentor Harbor, Presque Isle Bay, Port Dover, and Sturgeon Creek. In Lake Ontario the regulation...valued at close to 4 million dollars (Melski 1973), and the winter ice fishery was valued at 1.1 million dollars. Presque Isle Bay (which is on the

Ice Engineering: Ice Jams, Winter 2002-2003

DTIC Science & Technology

2004-07-01

located between Caribou and Fort Fairfield, and from Presque Isle and Washburn (NWS 2003i). Of the seven, four were reported in December and three...the towns of Washburn and Presque Isle ) was estimated to be one-quarter of a mile long in December. This jam remained in place until 21 April 2003...then appeared to break in half, sending the downstream floe of ice southeast through the town of Presque Isle while the most upstream section of

Changes in Rates of Shore Retreat, Lake Michigan, 1967-1976.

DTIC Science & Technology

1979-12-01

D.C., Apr. 1946. BERG, D.W., "Factors Affecting Beach Nourishment at Presque Isle Peninsula, Erie , Pennsylvania ," Proceedings of the Ninth Conference on...concern the behavior of beach fill at Presque Isle Peninsula on Lake Erie . Guidelines for moni- toring the effect of shore protection works in the Great...NTIS AD 631 520). BERG, D.W., and DUANE, D.B., "Effects of Particle Size and Distribution on Stability of Artificially Filled Beach, Presque Isle

Movements of brown bullheads in Presque Isle Bay, Lake Erie, Pennsylvania

USGS Publications Warehouse

Millard, M.J.; Smith, D.R.; Obert, E.; Grazio, J.; Bartron, M.L.; Wellington, C.; Grise, S.; Rafferty, S.; Wellington, R.; Julian, S.

2009-01-01

Presque Isle Bay, Lake Erie, was listed as an Area of Concern (AOC) by the International Joint Commission in part because of the high incidence of external tumor in brown bullheads. Verifying the source of the possible contaminant exposure is critical to addressing the AOC designation. We used telemetry tracking (n = 49 fish) to test the hypothesis that adult bullheads captured within the bay during spawning season do not exit the bay during the post-spawning summer and fall months. We analyzed genetic variation at 15 microsatellite loci for 112 adult fish from 5 locations, 4 inside the bay and 1 outside, in order to test for possible differences. Data from fixed-station receivers suggested fish did not leave Presque Isle Bay during the study period. Predicted locations outside Presque Isle Bay were only 0.1% of all predicted locations and were below the 0.2% error rate based on known manual relocations. However, there was evidence for movement within Presque Isle Bay. Most movement was between Misery Bay or Lagoons and the open bay area. Whereas telemetry results showed tendency for adult site fidelity, genetic results showed no differences among locations, indicating that there is a single panmictic population. Our telemetry data suggest that brown bullheads are likely a useful indicator species for environmental conditions in Presque Isle Bay, since adults likely are retained in the system.

Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhati, Mugdha; Lee, Christopher; Nancarrow, Amy L.

2008-09-03

LIM-homeodomain (LIM-HD) transcription factors form a combinatorial 'LIM code' that contributes to the specification of cell types. In the ventral spinal cord, the binary LIM homeobox protein 3 (Lhx3)/LIM domain-binding protein 1 (Ldb1) complex specifies the formation of V2 interneurons. The additional expression of islet-1 (Isl1) in adjacent cells instead specifies the formation of motor neurons through assembly of a ternary complex in which Isl1 contacts both Lhx3 and Ldb1, displacing Lhx3 as the binding partner of Ldb1. However, little is known about how this molecular switch occurs. Here, we have identified the 30-residue Lhx3-binding domain on Isl1 (Isl1{sub LBD}).more » Although the LIM interaction domain of Ldb1 (Ldb1{sub LID}) and Isl1{sub LBD} share low levels of sequence homology, X-ray and NMR structures reveal that they bind Lhx3 in an identical manner, that is, Isl1{sub LBD} mimics Ldb1{sub LID}. These data provide a structural basis for the formation of cell type-specific protein-protein interactions in which unstructured linear motifs with diverse sequences compete to bind protein partners. The resulting alternate protein complexes can target different genes to regulate key biological events.« less

Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons

PubMed Central

Pan, Y. Albert; Choy, Margaret; Prober, David A.; Schier, Alexander F.

2012-01-01

How neurons connect to form functional circuits is central to the understanding of the development and function of the nervous system. In the somatosensory system, perception of sensory stimuli to the head requires specific connections between trigeminal sensory neurons and their many target areas in the central nervous system. Different trigeminal subtypes have specialized functions and downstream circuits, but it has remained unclear how subtype-specific axonal projection patterns are formed. Using zebrafish as a model system, we followed the development of two trigeminal sensory neuron subtypes: one that expresses trpa1b, a nociceptive channel important for sensing environmental chemicals; and a distinct subtype labeled by an islet1 reporter (Isl1SS). We found that Trpa1b and Isl1SS neurons have overall similar axon trajectories but different branching morphologies and distributions of presynaptic sites. Compared with Trpa1b neurons, Isl1SS neurons display reduced branch growth and synaptogenesis at the hindbrain-spinal cord junction. The subtype-specific morphogenesis of Isl1SS neurons depends on the guidance receptor Robo2. robo2 is preferentially expressed in the Isl1SS subset and inhibits branch growth and synaptogenesis. In the absence of Robo2, Isl1SS afferents acquire many of the characteristics of Trpa1b afferents. These results reveal that subtype-specific activity of Robo2 regulates subcircuit morphogenesis in the trigeminal sensory system. PMID:22190641

Expression of Terminal Effector Genes in Mammalian Neurons Is Maintained by a Dynamic Relay of Transient Enhancers.

PubMed

Rhee, Ho Sung; Closser, Michael; Guo, Yuchun; Bashkirova, Elizaveta V; Tan, G Christopher; Gifford, David K; Wichterle, Hynek

2016-12-21

Generic spinal motor neuron identity is established by cooperative binding of programming transcription factors (TFs), Isl1 and Lhx3, to motor-neuron-specific enhancers. How expression of effector genes is maintained following downregulation of programming TFs in maturing neurons remains unknown. High-resolution exonuclease (ChIP-exo) mapping revealed that the majority of enhancers established by programming TFs are rapidly deactivated following Lhx3 downregulation in stem-cell-derived hypaxial motor neurons. Isl1 is released from nascent motor neuron enhancers and recruited to new enhancers bound by clusters of Onecut1 in maturing neurons. Synthetic enhancer reporter assays revealed that Isl1 operates as an integrator factor, translating the density of Lhx3 or Onecut1 binding sites into transient enhancer activity. Importantly, independent Isl1/Lhx3- and Isl1/Onecut1-bound enhancers contribute to sustained expression of motor neuron effector genes, demonstrating that outwardly stable expression of terminal effector genes in postmitotic neurons is controlled by a dynamic relay of stage-specific enhancers. Copyright © 2016 Elsevier Inc. All rights reserved.

Does among-population variation in burst swimming performance of sockeye salmon Oncorhynchus nerka fry reflect early life migrations?

PubMed

Sopinka, N M; Hinch, S G; Lotto, A G; Whitney, C K; Patterson, D A

2013-11-01

Using a fixed-speed test, burst swimming performance was found to vary among nine populations of emergent sockeye salmon Oncorhynchus nerka fry reared in a common-garden environment. No consistent relationship was, however, detected between difficulty of fry migration (upstream v. downstream) to rearing areas and total burst swimming duration or bursting rate. © 2013 The Fisheries Society of the British Isles.

The Emerging Shield. The Air Force and the Evolution of Continental Air Defense 1945-1960

DTIC Science & Technology

1991-01-01

flight plans other than those reported to the Presque Isle site. No one blamed the pilots; they had reported their changes in flighit to Canadian flight...monitor stations. Communications between the stations and ADC’s Presque Isle radar site had failed, and the course changes were not identified in the...Identification Zone: 134 "Pregnant Goose": 20 GOC on coast of: 156 Presque Isle , Maine: 170-71 Northw st emergency air defense for: Project CHARLEs: 145

76 FR 18938 - Changes in Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-06

... Isles Beach, 18070 Review. Collins Avenue, Sunny Isles Beach, FL 33160. Monroe (FEMA Docket No.: B.... Jim Schmidt, December 24, 2010 460277 No.: B-1156) of Lincoln County August 26, 2010; Chairman...

APM for a Constellation Intersatellite Link - EM Qualification and Lessons Learned

NASA Technical Reports Server (NTRS)

Hartel, Frank; Kozilek, Horst

2016-01-01

For an Intersatellite Link (ISL) of a future constellation program, a study phase was initiated by ESA to design a mechanism for Radio Frequency communication. Airbus DS Friedrichshafen (ADSF) proposed a design based on the Antenna Pointing Mechanism (APM) family with modifications that met the stated needs of the constellation. A qualification program was started beginning in September 2015 to verify the launch and thermal loads and the equipment performance (Radio Frequency, Pointing, Microvibration and Magnetic Moment). Technical challenges identified with the Engineering Model will be discussed within this paper.

Can simple tank changes benefit the welfare of laboratory zebrafish Danio rerio?

PubMed

Lee, C J; Tyler, C R; Paull, G C

2018-03-01

This study examined the effects of simple changes in the tank environment on the wellbeing of laboratory-maintained zebrafish Danio rerio. Groups of D. rerio were either housed in stable environments (where they were maintained in the same tanks throughout the study) or in environments subject to change (where they were periodically moved to novel but identical tanks) and the effects of these treatments on morphometry, reproductive success and aggressive behaviour assessed. No effect of simple tank changes was found on body condition, reproductive output or aggression, for the periods of time studied, indicating that more complex scenarios in housing tank conditions are required for significant welfare benefits for captive D. rerio. © 2018 The Fisheries Society of the British Isles.

Multiple births by a captive swellshark Cephaloscyllium ventriosum via facultative parthenogenesis.

PubMed

Feldheim, K A; Clews, A; Henningsen, A; Todorov, L; McDermott, C; Meyers, M; Bradley, J; Pulver, A; Anderson, E; Marshall, A

2017-03-01

Using a novel set of 12 microsatellites, a captive, adult female swellshark Cephaloscyllium ventriosum that produced five pups via parthenogenesis is described; naturally occurring parthenogenesis has been observed in every vertebrate class with the exception of mammals. As demonstrated in this study, a captive environment is ideal for long-term monitoring of animals under controlled conditions, and easily allows the detection of particular facets of their biology. © 2016 The Fisheries Society of the British Isles.

Experimental and Numerical Investigation of Vortical Structures in Lean Premixed Swirl-Stabilized Combustion

NASA Astrophysics Data System (ADS)

Taamallah, Soufien; Chakroun, Nadim; Shanbhogue, Santosh; Kewlani, Gaurav; Ghoniem, Ahmed

2015-11-01

A combined experimental and LES investigation is performed to identify the origin of major flow dynamics and vortical structures in a model gas turbine's swirl-stabilized turbulent combustor. Swirling flows in combustion lead to the formation of complex flow dynamics and vortical structures that can interact with flames and influence its stabilization. Our experimental results for non-reacting flow show the existence of large scale precession motion. The precessing vortex core (PVC) dynamics disappears with combustion but only above a threshold of equivalence ratio. In addition, large scale vortices along the inner shear layer (ISL) are observed. These structures interact with the ISL stabilized flame and contribute to its wrinkling. Next, the LES setup is validated against the flow field's low-order statistics and point temperature measurement in relevant areas of the chamber. Finally, we show that LES is capable of predicting the precession motion as well as the ISL vortices in the reacting case: we find that ISL vortices originate from a vortex core that is formed right downstream of the swirler's centerbody. The vortex core has a conical spiral shape resembling a corkscrew that interacts - as it winds out - with the flame when it reaches the ISL.

FAA Air Traffic Activity. Fiscal Year 1984.

DTIC Science & Technology

1984-09-30

ZRC 2 0 0 2 0 PRESCOTT A? N ZAB 111 2 36 66 7 PRESQUE ISLE ME N I TBW 249 9 80 P5 67 PRESQUE ISLE ME N low 1831 6 1186 51C 129 _ PRESTON NJ N I WRI...FTS 226-7816, Commerical Commercial 202-472-7478. 313-226-7816. Int’l Communication Agency, 1776 Pennsylvania Houston Bookstore, 45 College Center...OPERATIONS 211137 105151 13288 67476 25222 SALEM "CNARY FIELD ISLE ) N40 ITINERANT OPERATIONS 44167 0 2029 37960 6178 LOCAL OPERATIONS 19359 15697 3662

Microplastic in beach sediments of the Isle of Rügen (Baltic Sea) - Implementing a novel glass elutriation column.

PubMed

Hengstmann, Elena; Tamminga, Matthias; Vom Bruch, Constantin; Fischer, Elke Kerstin

2018-01-01

To extent the understanding on microplastics in the marine environment we performed a case study at four beaches on the Isle of Rügen considering abundance and spatial distribution of microplastics in beach sediments. For the analysis, density separation via a glass elutriation column was implemented. In advance, efficiencies were tested for two polymers, being not buoyant in water. Recovery rates of 80% for PET and 72% for PVC particles in sandy samples were achieved. A median abundance of 88.10 (Q 1 =55.01/Q 3 =114.72) microplastic particles per kg dry sediment or 2862.56 (Q 1 =1787.34/Q 3 =3727.28) particles per m 2 was found at the beaches on Rügen. Fibers were more abundant than fragments at all beaches. In this study, no statistically significant differences but only tendencies were determined between the beaches with different exposition and anthropogenic activity as well as for distribution patterns which showed that microplastic fragments accumulate in topographic depressions, similar to macrolitter items. Copyright © 2017 Elsevier Ltd. All rights reserved.

A Smart City Application: A Fully Controlled Street Lighting Isle Based on Raspberry-Pi Card, a ZigBee Sensor Network and WiMAX

PubMed Central

Leccese, Fabio; Cagnetti, Marco; Trinca, Daniele

2014-01-01

A smart city application has been realized and tested. It is a fully remote controlled isle of lamp posts based on new technologies. It has been designed and organized in different hierarchical layers, which perform local activities to physically control the lamp posts and transmit information with another for remote control. Locally, each lamp post uses an electronic card for management and a ZigBee tlc network transmits data to a central control unit, which manages the whole isle. The central unit is realized with a Raspberry-Pi control card due to its good computing performance at very low price. Finally, a WiMAX connection was tested and used to remotely control the smart grid, thus overcoming the distance limitations of commercial Wi-Fi networks. The isle has been realized and tested for some months in the field. PMID:25529206

A smart city application: a fully controlled street lighting isle based on Raspberry-Pi card, a ZigBee sensor network and WiMAX.

PubMed

Leccese, Fabio; Cagnetti, Marco; Trinca, Daniele

2014-12-18

A smart city application has been realized and tested. It is a fully remote controlled isle of lamp posts based on new technologies. It has been designed and organized in different hierarchical layers, which perform local activities to physically control the lamp posts and transmit information with another for remote control. Locally, each lamp post uses an electronic card for management and a ZigBee tlc network transmits data to a central control unit, which manages the whole isle. The central unit is realized with a Raspberry-Pi control card due to its good computing performance at very low price. Finally, a WiMAX connection was tested and used to remotely control the smart grid, thus overcoming the distance limitations of commercial Wi-Fi networks. The isle has been realized and tested for some months in the field.

An oasis of fertility on a barren island: earthworms at Papadil, Isle of Rum

Treesearch

K.R. Butt; C.N.  Lowe; Mac Callaham; V.  Nuutinen

2016-01-01

The Isle of Rum, Inner Hebrides, has an impoverished earthworm fauna as the soils are generally acidic and nutrient-poor. Species associated with human habitation are found around deserted crofting settlements subjected to

76 FR 19474 - Columbia Forest Products, Inc., Presque Isle Division; Presque Isle, Maine; Notice of Revised...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-07

... does not include leased workers or workers supplied from a temporary staffing agency. A careful review... investigation, including U.S. aggregate imports of like or directly competitive articles and other available...

Low cardiac and aerobic scope in a coastal population of sockeye salmon Oncorhynchus nerka with a short upriver migration.

PubMed

Eliason, E J; Wilson, S M; Farrell, A P; Cooke, S J; Hinch, S G

2013-06-01

This study showed that a coastal population (Harrison) of Fraser River sockeye salmon Oncorhynchus nerka had a lower aerobic and cardiac scope compared with interior populations with more challenging upriver spawning migrations, providing additional support to the idea that Fraser River O. nerka populations have adapted physiologically to their local migratory environment. © 2013 The Authors. Journal of Fish Biology © 2013 The Fisheries Society of the British Isles.

Exploring Global Change In Place-Based Case Studies

NASA Astrophysics Data System (ADS)

Moosavi, S. C.

2011-12-01

The complexity of global climate change makes the subject challenging for the average student, particularly given the nuanced feedbacks and exceptions to the general "warming" or "drying" trend that may be experienced at the local and regional level at which most people experience geologic processes. Geoscience educators can reduce these barriers and draw in student learners by adopting a place-based approach to teaching and researching geologic principles that relate to global change. Assisting students in recognizing and understanding the geologic environment in which they live and study has the side benefit of making the potential effect of climate change tangible. This presentation will review several approaches for using place-based case studies to explore global climate change issues in large lecture, small seminar, field research and service learning environments. The special place project used in large introductory physical geology courses requires each student to select a place familiar and unique to them for an in depth study of the common course content as the semester progresses. Students are specifically tasked with identifying how their site came to be, the geologic processes that act upon it today, how the site may have been different during the last glacial advance and how global climate change (specifically warming of 3OC over 50 years) might impact the site. The concept that change has occurred at the student's site in the past, even far from glacial environments, opens students to the scale of potential anthropogenic climate change. A freshman seminar Global Warming & Climate Change - Service in Preparation for Climate Change: The Second Battle of New Orleans focused on the environmental threats to New Orleans and southeastern Louisiana resulting from regional land use decisions in the centuries before Hurricane Katrina, and the threat that global change relating to sea level rise, acceleration of the hydrologic cycle and intensification of hurricanes poses to this region specifically and as a model for similar coastal regions around the world. The small seminar format is an excellent approach to target a specific topic and audience for examining global climate change on the ground where students stand. The Grand Isle Project began as a service learning option for students in a large introductory physical geology course. The initial goal of the project was to expose general education students to a rapidly eroding and subsiding barrier island whose loss threatens national oil and gas infrastructure and storm surge defenses of New Orleans. The battle fought by the Army Corps of Engineers and local officials to defend the beach on Grand Isle against the ravages of 2 hurricanes and the BP oil spill brought together issues of human manipulation of river/sediment systems, continued energy dependence on fossil fuels, changes to the severity of natural weather events and the inevitable natural subsidence demonstrating the complexity of global change in a specific place familiar to all members of the class. A subset of these students were afforded the opportunity to engage in undergraduate research, contributing to decisions guiding the clean up and preservation of this portion of the coast.

Transportation Lines on the Great Lakes System; Transportation Series 3; 1980.

DTIC Science & Technology

1982-05-01

I 94 24 29 O 22. SPAR NONE CALCITE, 1952 ELECTRIC, STEEL MICH. (221 LITTON GREAT LA ES CORP, MJV PRESQUE ISLE TOWBOAT; STEEL 107 141 IS S4 5 2 21...1464 - -6 LIGHT NONE ERIE , PA, 1973PRESQUE ISLE BARGE, STEEL 22251 94 974 104 104 . 12 - 5720 7 6, LIGHT SE4F-UNLOADIN- DO 1973 ELEC., 250’ BOOM- 10,000...MOTOR, DIESEL. 1 37 41 I t 230 -, PAST NONE LGONAC. 1948 STEEL NIC. (23) PARKER BOAT 4INI ERIE ISLE MOTOR, DIESEL, 4 6 6 24 2 9 330 2 16014o LIGHT

Great Lakes and St. Lawrence Seaway Navigation Season Extension. Volume 1. Main Report and Final Environmental Impact Statement

DTIC Science & Technology

1979-08-01

MN - Taconite, MN - Silver Bay, MN - Presque Isle , MI - Marquette, MI 30 iC V.)Lake Michigan - Burns Harbor, IN - Gary, IN - Indiana, IN - Milwaukee...14,263 3.7 Presque Isle , MI 1,703 516 3.3 Marquette, MI 159 192 0.8 Taconite, MN 5,640 1,723 3.3 Silver Bay, MN 5,623 1,744 3.2 Ash-and, WI 250 668 0.4...required -for Taconite, Two Harbors, and Presque Isle and that only a single line of bubblers would be required in Ashland, MaLquette, and Silver Bay

MicroRNA-31 suppresses the self-renewal capability of α2δ1+ liver tumor-initiating cells by targeting ISL1.

PubMed

Zhang, Yuan; Zhao, Wei; Han, Haibo; Li, Sheng; Chen, Dongji; Zhang, Zhiqian

2017-10-20

Accumulating evidence demonstrates that miRNAs, a class of small non-coding RNAs, are involved in the regulation of tumor-initiating cells (TICs) which are considered to be the origin of cancer development according to the cancer stem cell hypothesis. We have previously identified that miR-31 may play suppressive roles in α2δ1 + hepatocellular carcinoma (HCC) TICs. Here, we confirm that the expression of miR-31 is significantly downregulated in α2δ1 + HCC TICs. Overexpression of miR-31 in α2δ1 + HCC TICs results in significant suppression of the self-renewal and tumorigenicity abilities of these cells. Conversely, knockdown the expression of miR-31 in PLC/PRF/5 cells is able to reprogram them into TICs with stem cell-like properties. Furthermore, the expression of ISL LIM Homeobox 1(ISL1), a transcription factor involved in recognition of undifferentiated cardiac progenitors, is negatively regulated by miR-31, and the luciferase reporters' activities with the 3'-UTRs of ISL1 are inhibited significantly by miR-31. Collectively, our results suggest that miR-31 can negatively regulate the self-renewal ability of α2δ1 + liver TICs via silencing ISL1 .

Military uses of groundwater: a driver of innovation?

NASA Astrophysics Data System (ADS)

Robins, N. S.; Rose, E. P. F.

2009-07-01

Military need has been a positive driver to the development of the modern day, and now mature, science of hydrogeology. The important synergy between geology and water supply was appreciated by military men in the mid-nineteenth century but the first real test of this learning only took place in the First World War. German, British and American geologists then mapped water resources and the potential for exploiting groundwater in Belgium and northern France. Technical innovations included deployment of rapid drilling techniques and the promotion of well screens for use in unconsolidated sediments. The mapping techniques were developed further during the Second World War when innovative remote mapping of enemy-occupied territory became an important planning tool to both Allied and German armies. Work in North Africa and other arid and semi-arid terrains promoted insight into the occurrence of groundwater in fresh-water aquifers little replenished by recharge. Mapping of hard rock basement-type environments in the islands of Jersey and Guernsey by German geologists was a concept new to the British Isles. Collectively, these varied initiatives provided part of the foundation for post-Second World War development of modern-day applied hydrogeology.

The paleohydrology of Lower Cretaceous seasonal wetlands, Isle of Wight, southern England

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wright, V.P.; Taylor, K.G.; Beck, V.H.

2000-05-01

The floodplain deposits of the Wealden Group (Lower Cretaceous) of the Isle of Wight, southern England, were formed in a seasonal wetland setting, a type of environment widespread today along higher-order tropical and subtropical river systems but rarely identified in the geological record. The unit consists of four main lithofacies: sheet sandstones with dinosaur footprint casts; green-gray mudstones with vertebrate remains, abundant lignite, pyrite, and siderite; spectacularly color-mottled mudstones with goethite and locally pseudo-anticlines; and red mudstones with pseudo-anticlines, hematite, and carbonate nodules. The sheet sandstones are interpreted as crevasse deposits; the green-gray mudstones were deposited in shallow ponds onmore » the floodplain, which acted as sinks for debris released by local floods following wildfires; the mottled mudstones represent surface-water gley soils formed in seasonally waterlogged areas; and the red mudstones resemble present-day Vertisols that formed on topographically elevated areas only intermittently flooded. These mudstones show vertical transitions from one to another, and although they could be interpreted as components of simple catenas, the absence of associated facies changes implies that topographic differences were not the only control. It is proposed that these three mudstone types formed as seasonal wetland catenas, in which differences in soil drainage conditions resulted from variations in the flooding hydroperiod affecting areas with minor relief differences, rather than drainage variability simply reflecting static topographic differences. Such seasonal wetland systems are rarely documented in the stratigraphic record despite being a widespread environment in present-day tropical regions, and the Wealden deposits are used to identify criteria for the recognition of this important environment in the rock record. These southern English wetlands are compared with other Lower Cretaceous wetlands from northern Spain, enabling hydrological factors which controlled deposition to be recognized.« less

ISLE: Intelligent Selection of Loop Electronics. A CLIPS/C++/INGRES integrated application

NASA Technical Reports Server (NTRS)

Fischer, Lynn; Cary, Judson; Currie, Andrew

1990-01-01

The Intelligent Selection of Loop Electronics (ISLE) system is an integrated knowledge-based system that is used to configure, evaluate, and rank possible network carrier equipment known as Digital Loop Carrier (DLC), which will be used to meet the demands of forecasted telephone services. Determining the best carrier systems and carrier architectures, while minimizing the cost, meeting corporate policies and addressing area service demands, has become a formidable task. Network planners and engineers use the ISLE system to assist them in this task of selecting and configuring the appropriate loop electronics equipment for future telephone services. The ISLE application is an integrated system consisting of a knowledge base, implemented in CLIPS (a planner application), C++, and an object database created from existing INGRES database information. The embedibility, performance, and portability of CLIPS provided us with a tool with which to capture, clarify, and refine corporate knowledge and distribute this knowledge within a larger functional system to network planners and engineers throughout U S WEST.

Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity

PubMed Central

Mazzoni, Esteban O; Mahony, Shaun; Closser, Michael; Morrison, Carolyn A; Nedelec, Stephane; Williams, Damian J; An, Disi; Gifford, David K; Wichterle, Hynek

2013-01-01

Efficient transcriptional programming promises to open new frontiers in regenerative medicine. However, mechanisms by which programming factors transform cell fate are unknown, preventing more rational selection of factors to generate desirable cell types. Three transcription factors, Ngn2, Isl1 and Lhx3, were sufficient to program rapidly and efficiently spinal motor neuron identity when expressed in differentiating mouse embryonic stem cells. Replacement of Lhx3 by Phox2a led to specification of cranial, rather than spinal, motor neurons. Chromatin immunoprecipitation–sequencing analysis of Isl1, Lhx3 and Phox2a binding sites revealed that the two cell fates were programmed by the recruitment of Isl1-Lhx3 and Isl1-Phox2a complexes to distinct genomic locations characterized by a unique grammar of homeodomain binding motifs. Our findings suggest that synergistic interactions among transcription factors determine the specificity of their recruitment to cell type–specific binding sites and illustrate how a single transcription factor can be repurposed to program different cell types. PMID:23872598

Orbit determination of the Next-Generation Beidou satellites with Intersatellite link measurements and a priori orbit constraints

NASA Astrophysics Data System (ADS)

Ren, Xia; Yang, Yuanxi; Zhu, Jun; Xu, Tianhe

2017-11-01

Intersatellite Link (ISL) technology helps to realize the auto update of broadcast ephemeris and clock error parameters for Global Navigation Satellite System (GNSS). ISL constitutes an important approach with which to both improve the observation geometry and extend the tracking coverage of China's Beidou Navigation Satellite System (BDS). However, ISL-only orbit determination might lead to the constellation drift, rotation, and even lead to the divergence in orbit determination. Fortunately, predicted orbits with good precision can be used as a priori information with which to constrain the estimated satellite orbit parameters. Therefore, the precision of satellite autonomous orbit determination can be improved by consideration of a priori orbit information, and vice versa. However, the errors of rotation and translation in a priori orbit will remain in the ultimate result. This paper proposes a constrained precise orbit determination (POD) method for a sub-constellation of the new Beidou satellite constellation with only a few ISLs. The observation model of dual one-way measurements eliminating satellite clock errors is presented, and the orbit determination precision is analyzed with different data processing backgrounds. The conclusions are as follows. (1) With ISLs, the estimated parameters are strongly correlated, especially the positions and velocities of satellites. (2) The performance of determined BDS orbits will be improved by the constraints with more precise priori orbits. The POD precision is better than 45 m with a priori orbit constrain of 100 m precision (e.g., predicted orbits by telemetry tracking and control system), and is better than 6 m with precise priori orbit constraints of 10 m precision (e.g., predicted orbits by international GNSS monitoring & Assessment System (iGMAS)). (3) The POD precision is improved by additional ISLs. Constrained by a priori iGMAS orbits, the POD precision with two, three, and four ISLs is better than 6, 3, and 2 m, respectively. (4) The in-plane link and out-of-plane link have different contributions to observation configuration and system observability. The POD with weak observation configuration (e.g., one in-plane link and one out-of-plane link) should be tightly constrained with a priori orbits.

33 CFR 80.707 - Cape Romain, SC to Sullivans Island, SC.

Code of Federal Regulations, 2010 CFR

2010-07-01

... from Dewees Island to Isle of Palms. (f) A line formed by the centerline of the highway bridge between Isle of Palms and Sullivans Island over Breach Inlet. ... Island, SC. 80.707 Section 80.707 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND...

33 CFR 80.707 - Cape Romain, SC to Sullivans Island, SC.

Code of Federal Regulations, 2011 CFR

2011-07-01

... from Dewees Island to Isle of Palms. (f) A line formed by the centerline of the highway bridge between Isle of Palms and Sullivans Island over Breach Inlet. ... Island, SC. 80.707 Section 80.707 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND...

CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy.

PubMed

Huang, Zhan-Peng; Young Seok, Hee; Zhou, Bin; Chen, Jinghai; Chen, Jian-Fu; Tao, Yazhong; Pu, William T; Wang, Da-Zhi

2012-03-16

Mammalian heart has minimal regenerative capacity. In response to mechanical or pathological stress, the heart undergoes cardiac remodeling. Pressure and volume overload in the heart cause increased size (hypertrophic growth) of cardiomyocytes. Whereas the regulatory pathways that activate cardiac hypertrophy have been well-established, the molecular events that inhibit or repress cardiac hypertrophy are less known. To identify and investigate novel regulators that modulate cardiac hypertrophy. Here, we report the identification, characterization, and functional examination of a novel cardiac Isl1-interacting protein (CIP). CIP was identified from a bioinformatic search for novel cardiac-expressed genes in mouse embryonic hearts. CIP encodes a nuclear protein without recognizable motifs. Northern blotting, in situ hybridization, and reporter gene tracing demonstrated that CIP is highly expressed in cardiomyocytes of developing and adult hearts. Yeast two-hybrid screening identified Isl1, a LIM/homeodomain transcription factor essential for the specification of cardiac progenitor cells in the second heart field, as a cofactor of CIP. CIP directly interacted with Isl1, and we mapped the domains of these two proteins, which mediate their interaction. We show that CIP represses the transcriptional activity of Isl1 in the activation of the myocyte enhancer factor 2C. The expression of CIP was dramatically reduced in hypertrophic cardiomyocytes. Most importantly, overexpression of CIP repressed agonist-induced cardiomyocyte hypertrophy. Our studies therefore identify CIP as a novel regulator of cardiac hypertrophy.

76 FR 61472 - Culturally Significant Objects Imported for Exhibition

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-04

... DEPARTMENT OF STATE [Public Notice: 7634] Culturally Significant Objects Imported for Exhibition Determinations: ``The Game of Kings: Medieval Ivory Chessmen From the Isle of Lewis'' SUMMARY: Notice is hereby... objects to be included in the exhibition ``The Game of Kings: Medieval Ivory Chessmen from the Isle of...

33 CFR 110.206 - Detroit River, Michigan.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Detroit River, Michigan. 110.206... ANCHORAGE REGULATIONS Anchorage Grounds § 110.206 Detroit River, Michigan. (a) The Anchorage grounds. Belle Isle Anchorage. The area is in the Detroit River immediately downstream from Belle Isle on the U.S...

75 FR 31505 - Bureau of Political-Military Affairs: Directorate of Defense Trade Controls; Notifications to the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-03

... Satellite from the Baikonur Cosmodrome in Kazakhstan. The United States Government is prepared to license... support the transfer of the ProtoStarII satellite Commercial Communication Satellite from ProtoStar Satellite Systems, Inc., Bermuda to SES Satellite Leasing Limited, Isle of Man, British Isles. The United...

Natural resources interpretation: the role of researchers a new-old approach

Treesearch

Mark Gleason

2002-01-01

For the past several years interpretive programs for visitors at Isle Royale National Park have included presentations by natural resources researchers. These researchers are presenting the findings of their Lake Superior and Isle Royale National Park research directly to the public. This cooperative and developing project involves many individuals representing many...

British Isles Field Experience: An Initiative in International Education.

ERIC Educational Resources Information Center

Martin, William J.

The British Isles Field Experience (BIFE) program was initiated at Williamsport Area Community College (WACC) to provide a group of WACC faculty and staff members with individual and group activities of a personal, professional, and cultural nature in order to promote an international perspective that can be infused into student, collegiate, and…

A Multi-step Transcriptional and Chromatin State Cascade Underlies Motor Neuron Programming from Embryonic Stem Cells.

PubMed

Velasco, Silvia; Ibrahim, Mahmoud M; Kakumanu, Akshay; Garipler, Görkem; Aydin, Begüm; Al-Sayegh, Mohamed Ahmed; Hirsekorn, Antje; Abdul-Rahman, Farah; Satija, Rahul; Ohler, Uwe; Mahony, Shaun; Mazzoni, Esteban O

2017-02-02

Direct cell programming via overexpression of transcription factors (TFs) aims to control cell fate with the degree of precision needed for clinical applications. However, the regulatory steps involved in successful terminal cell fate programming remain obscure. We have investigated the underlying mechanisms by looking at gene expression, chromatin states, and TF binding during the uniquely efficient Ngn2, Isl1, and Lhx3 motor neuron programming pathway. Our analysis reveals a highly dynamic process in which Ngn2 and the Isl1/Lhx3 pair initially engage distinct regulatory regions. Subsequently, Isl1/Lhx3 binding shifts from one set of targets to another, controlling regulatory region activity and gene expression as cell differentiation progresses. Binding of Isl1/Lhx3 to later motor neuron enhancers depends on the Ebf and Onecut TFs, which are induced by Ngn2 during the programming process. Thus, motor neuron programming is the product of two initially independent transcriptional modules that converge with a feedforward transcriptional logic. Copyright © 2017 Elsevier Inc. All rights reserved.

CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy

PubMed Central

Huang, Zhan-Peng; Seok, Hee Young; Zhou, Bin; Chen, Jinghai; Chen, Jian-Fu; Tao, Yazhong; Pu, William T.; Wang, Da-Zhi

2012-01-01

Rationale Mammalian heart has minimal regenerative capacity. In response to mechanical or pathological stress, the heart undergoes cardiac remodeling. Pressure and volume overload in the heart cause increased size (hypertrophic growth) of cardiomyocytes. Whereas the regulatory pathways that activate cardiac hypertrophy have been well established, the molecular events that inhibit or repress cardiac hypertrophy are less known. Objective To identify and investigate novel regulators that modulate cardiac hypertrophy. Methods and Results Here, we report the identification, characterization and functional examination of CIP, a novel cardiac Isl1-interacting protein. CIP was identified from a bioinformatic search for novel cardiac-expressed genes in mouse embryonic hearts. CIP encodes a nuclear protein without recognizable motifs. Northern blotting, in situ hybridization and reporter gene tracing demonstrated that CIP is highly expressed in cardiomyocytes of developing and adult hearts. Yeast-two-hybrid screening identified Isl1, a LIM/homeodomain transcription factor essential for the specification of cardiac progenitor cells in the second heart field, as a co-factor of CIP. CIP directly interacted with Isl1 and we mapped the domains of these two proteins which mediate their interaction. We show that CIP represses the transcriptional activity of Isl1 in the activation of the MEF2C enhancer. The expression of CIP was dramatically reduced in hypertrophic cardiomyocytes. Most importantly, overexpression of CIP repressed agonist-induced cardiomyocyte hypertrophy. Conclusions Our studies therefore identify CIP a novel regulator of cardiac hypertrophy. PMID:22343712

Measurement of impulse peak insertion loss from two acoustic test fixtures and four hearing protector conditions with an acoustic shock tube

PubMed Central

Murphy, William J.; Fackler, Cameron J.; Berger, Elliott H.; Shaw, Peter B.; Stergar, Mike

2015-01-01

Impulse peak insertion loss (IPIL) was studied with two acoustic test fixtures and four hearing protector conditions at the E-A-RCAL Laboratory. IPIL is the difference between the maximum estimated pressure for the open-ear condition and the maximum pressure measured when a hearing protector is placed on an acoustic test fixture (ATF). Two models of an ATF manufactured by the French-German Research Institute of Saint-Louis (ISL) were evaluated with high-level acoustic impulses created by an acoustic shock tube at levels of 134 decibels (dB), 150 dB, and 168 dB. The fixtures were identical except that the E-A-RCAL ISL fixture had ear canals that were 3 mm longer than the National Institute for Occupational Safety and Health (NIOSH) ISL fixture. Four hearing protection conditions were tested: Combat Arms earplug with the valve open, ETYPlugs® earplug, TacticalPro headset, and a dual-protector ETYPlugs earplug with TacticalPro earmuff. The IPILs measured for the E-A-RCAL fixture were 1.4 dB greater than the National Institute for Occupational Safety and Health (NIOSH) ISL ATF. For the E-A-RCAL ISL ATF, the left ear IPIL was 2.0 dB greater than the right ear IPIL. For the NIOSH ATF, the right ear IPIL was 0.3 dB greater than the left ear IPIL. PMID:26356380

Slit and semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube

PubMed Central

Lee, Hojae; Kim, Minkyung; Kim, Namhee; Macfarlan, Todd; Pfaff, Samuel L.; Mastick, Grant S.; Song, Mi-Ryoung

2015-01-01

Motor neurons send out axons to peripheral muscles while their cell bodies remain in the ventral spinal cord. The unique configuration of motor neurons spanning the border between the CNS and PNS has been explained by structural barriers such as boundary cap (BC) cells, basal lamina and radial glia. However, mechanisms in motor neurons that retain their position have not been addressed yet. Here we demonstrate that the Islet1 (Isl1) and Islet2 (Isl2) transcription factors, which are essential for acquisition of motor neuron identity, also contribute to restrict motor neurons within the neural tube. In mice that lack both Isl1 and Isl2, large numbers of motor neurons exited the neural tube, even prior to the appearance of BC cells at the ventral exit points. Transcriptional profiling of motor neurons derived from Isl1 null embryonic stem cells revealed that transcripts of major genes involved in repulsive mechanisms were misregulated. Particularly, expression of Neuropilin1 (Npr1) and Slit2 mRNA was diminished in Islet mutant mice, and these could be target genes of the Islet proteins. Consistent with this mechanism, Robo and Slit mutations in mice and knockdown of Npr1 and Slit2 in chick embryos caused motor neurons to migrate to the periphery. Together, our study suggests that Islet genes engage Robo-Slit and Neuropilin-Semaphorin signaling in motor neurons to retain motor somata within the CNS. PMID:25843547

Functional morphology of the tetra fish Astyanax lacustris differs between divergent habitats in the Pantanal wetlands.

PubMed

Costa-Pereira, R; Araújo, M S; Paiva, F; Tavares, L E R

2016-08-01

This study investigated whether the body morphology of the tetra fish Astyanax lacustris (previously Astyanax asuncionensis) varied between populations inhabiting one lagoon (a lentic, shallow environment, with great habitat complexity created by aquatic macrophytes) and an adjacent river (a deeper, lotic environment where aquatic macrophytes are scarce) in a seasonally flooded wetland, despite population mixing during the wet season. Morphological differences matched a priori predictions of the theory relating functional body morphology and swimming performance in fishes between lagoon and river habitats. Observed morphological variation could have resulted from adaptive habitat choice by tetras, predation by piscivores and adaptive phenotypic plasticity during development. © 2016 The Fisheries Society of the British Isles.

ISS Local Environment Spectrometers (ISLES)

NASA Technical Reports Server (NTRS)

Krause, Linda Habash; Gilchrist, Brian E.

2014-01-01

In order to study the complex interactions between the space environment surrounding the ISS and the ISS surface materials, we propose to use lowcost, high-TRL plasma sensors on the ISS robotic arm to probe the ISS space environment. During many years of ISS operation, we have been able to condut effective (but not perfect) extravehicular activities (both human and robotic) within the perturbed local ISS space environment. Because of the complexity of the interaction between the ISS and the LEO space environment, there remain important questions, such as differential charging at solar panel junctions (the so-called "triple point" between conductor, dielectric, and space plasma), increased chemical contamination due to ISS surface charging and/or thruster activation, water dumps, etc, and "bootstrap" charging of insulating surfaces. Some compelling questions could synergistically draw upon a common sensor suite, which also leverages previous and current MSFC investments. Specific questions address ISS surface charging, plasma contactor plume expansion in a magnetized drifting plasma, and possible localized contamination effects across the ISS.

Earth observations taken by the Expedition 14 crew

NASA Image and Video Library

2007-03-10

ISS014-E-16597 (10 March 2007) --- Isles of Scilly, United Kingdom is featured in this image photographed by an Expedition 14 crewmember on the International Space Station. The Isles of Scilly, an archipelago of approximately 150 islands, is located some 44 kilometers southwest of the westernmost point of England (Land's End). According to scientists, the islands are an erosional remnant of an ancient granite intrusion, and are notable because they have been inhabited for over 4000 years. Historical and geological evidence cited by NASA scientists on the Isles indicates that many of the islands were larger and/or connected in the recent past--this could be due to local subsidence, rising sea levels, or a combination of both factors. Even today, it is possible to walk between certain islands during low tides. The Isles have been designated a United Kingdom Area of Outstanding Natural Beauty due to their unique landscape, ecology, and historical significance. The potential effect of rising sea level on the Isles is a primary concern for both long-term ecosystem health and human habitability. This image illustrates the geographic configuration of the archipelago, and its effect on ocean wave patterns. Long linear swells oriented northeast-southwest and moving to the southeast (from upper left to lower right) are diffracted (bent) as they approach the coastlines and small shoals of the Isles. The wave diffraction forms complex interacting surface patterns--this is most clearly visible southwest of St. Mary's island (left). The dominant ocean wave pattern resumes to the southeast of St. Mary's, but with an additional northwest-southeast oriented pattern superimposed, possibly due to winds originating in the English channel to the east (not shown). Suspended, tan-colored sediments visible within and around the archipelago are locally derived from continuing wave erosion of the granite forming the islands and remobilization of beach sands. Bright white areas in the photograph are waves breaking on shoals.

Body concentration of caesium-137 in patients from Western Isles of Scotland.

PubMed Central

Isles, C G; Robertson, I; Macleod, J A; Preston, T; East, B W; Hole, D J; Lever, A F

1991-01-01

OBJECTIVES--To compare caesium-137 concentrations in patients from the Western Isles Health Board, Glasgow area, and other parts of the Scottish mainland, and to investigate the source of 137Cs in patients from the Western Isles. DESIGN--Study of hypertensive patients having electrolyte concentrations measured, including 137Cs. Interview by questionnaire of island subjects about intake of foods likely to contain radiocaesium and the source of these foods. Measurement of 137Cs and 134Cs in food, urine, and vegetation. SETTING--Scottish mainland and Western Isles, 1979-86. All measurements before Chernobyl nuclear accident. PATIENTS--413 consecutive patients referred to the blood pressure unit for investigation of hypertension. 60 from the Western Isles, including 44 from North Uist; 32 from North Uist participated in the dietary analysis. MAIN OUTCOME MEASURES--Concentration of radiocaesium in the body, urine, food, and vegetation. Islanders' consumption of local produce. RESULTS--Patients from the Western Isles had five times higher body concentrations of 137Cs (median 2.54 (interquartile range 1.25-3.73)) Bq/gK) than did patients from around Glasgow (0.47 (0.26-0.66) Bq/gK) and other parts of the Scottish mainland (0.42 (0.24-0.71) Bq/gK). Islanders often consumed local milk and mutton, but ate local fish rarely. 137Cs and 134Cs were present in coastal (21.6 Bq/kg 137Cs, 0.25 Bq/kg 134Cs) and moorland (135.9, 0.65 Bq/kg) grasses and in islanders' urine (2.01, 0.013 Bq/l). Lower concentrations (0.336, 0.004 Bq/l), were found in the urine of Glasgow controls (p less than 0.001 for both isotopes). CONCLUSIONS--Islanders have excess body 137Cs concentrations, most of which probably comes from local milk and lamb. The radioactivity is not above the recommended safety limit. The presence of 134Cs suggests that nuclear reprocessing is the source of some of the radiocaesium. PMID:1906765

Initial results of centralized autonomous orbit determination of the new-generation BDS satellites with inter-satellite link measurements

NASA Astrophysics Data System (ADS)

Tang, Chengpan; Hu, Xiaogong; Zhou, Shanshi; Liu, Li; Pan, Junyang; Chen, Liucheng; Guo, Rui; Zhu, Lingfeng; Hu, Guangming; Li, Xiaojie; He, Feng; Chang, Zhiqiao

2018-01-01

Autonomous orbit determination is the ability of navigation satellites to estimate the orbit parameters on-board using inter-satellite link (ISL) measurements. This study mainly focuses on data processing of the ISL measurements as a new measurement type and its application on the centralized autonomous orbit determination of the new-generation Beidou navigation satellite system satellites for the first time. The ISL measurements are dual one-way measurements that follow a time division multiple access (TDMA) structure. The ranging error of the ISL measurements is less than 0.25 ns. This paper proposes a derivation approach to the satellite clock offsets and the geometric distances from TDMA dual one-way measurements without a loss of accuracy. The derived clock offsets are used for time synchronization, and the derived geometry distances are used for autonomous orbit determination. The clock offsets from the ISL measurements are consistent with the L-band two-way satellite, and time-frequency transfer clock measurements and the detrended residuals vary within 0.5 ns. The centralized autonomous orbit determination is conducted in a batch mode on a ground-capable server for the feasibility study. Constant hardware delays are present in the geometric distances and become the largest source of error in the autonomous orbit determination. Therefore, the hardware delays are estimated simultaneously with the satellite orbits. To avoid uncertainties in the constellation orientation, a ground anchor station that "observes" the satellites with on-board ISL payloads is introduced into the orbit determination. The root-mean-square values of orbit determination residuals are within 10.0 cm, and the standard deviation of the estimated ISL hardware delays is within 0.2 ns. The accuracy of the autonomous orbits is evaluated by analysis of overlap comparison and the satellite laser ranging (SLR) residuals and is compared with the accuracy of the L-band orbits. The results indicate that the radial overlap differences between the autonomous orbits are less than 15.0 cm for the inclined geosynchronous orbit (IGSO) satellites and less than 10.0 cm for the MEO satellites. The SLR residuals are approximately 15.0 cm for the IGSO satellites and approximately 10.0 cm for the MEO satellites, representing an improvement over the L-band orbits.

Manx Gaelic: The Manx Gaelic Language in Education in the Isle of Man. Regional Dossiers Series

ERIC Educational Resources Information Center

McArdle, Fiona, Comp.; Teare, Robert, Comp.

2016-01-01

This regional dossier aims at providing a concise description of and basic statistics on minority language education in a specific region of Europe--the Isle of Man. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative…

Rocks at Belle-Isle, Port-Domois, Claude Monet

ERIC Educational Resources Information Center

Rauch, Marion Cosgrove

2004-01-01

This article is a description of the artist Claude Monet. The article describes the life and art of Claude Monet, focusing in on his work, Rocks at Bell-Isle, Port-Domois. A brief discussion of the significant elements of the painting is provided. The article also includes a list of discussion questions and suggested classroom activities.

Rural Governance, Community Empowerment and the New Institutionalism: A Case Study of the Isle of Wight

ERIC Educational Resources Information Center

Clark, David; Southern, Rebekah; Beer, Julian

2007-01-01

This article compares two different institutional models--state-sponsored rural partnerships and community-based development trusts--for engaging and empowering local communities in area-based regeneration, using the Isle of Wight as a case study. Following a critical review of the literature on community governance, we evaluate the effectiveness…

76 FR 72920 - Notification of a Public Teleconference of the Chartered Science Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-28

... Document ``Considerations Related to Post-Closure Monitoring of Uranium In-Situ ISL/ISR Sites.'' DATES: The... Monitoring of Uranium In-Situ ISL/ISR Sites.'' The SAB will comply with the provisions of FACA and all... Environmental Protection Standards for Uranium and Thorium Mill Tailings in regard to underground In-Situ Leach...

The Transcription Factors Islet and Lim3 Combinatorially Regulate Ion Channel Gene Expression

PubMed Central

Wolfram, Verena; Southall, Tony D.; Günay, Cengiz; Prinz, Astrid A.; Brand, Andrea H.

2014-01-01

Expression of appropriate ion channels is essential to allow developing neurons to form functional networks. Our previous studies have identified LIM-homeodomain (HD) transcription factors (TFs), expressed by developing neurons, that are specifically able to regulate ion channel gene expression. In this study, we use the technique of DNA adenine methyltransferase identification (DamID) to identify putative gene targets of four such TFs that are differentially expressed in Drosophila motoneurons. Analysis of targets for Islet (Isl), Lim3, Hb9, and Even-skipped (Eve) identifies both ion channel genes and genes predicted to regulate aspects of dendritic and axonal morphology. Significantly, some ion channel genes are bound by more than one TF, consistent with the possibility of combinatorial regulation. One such gene is Shaker (Sh), which encodes a voltage-dependent fast K+ channel (Kv1.1). DamID reveals that Sh is bound by both Isl and Lim3. We used body wall muscle as a test tissue because in conditions of low Ca2+, the fast K+ current is carried solely by Sh channels (unlike neurons in which a second fast K+ current, Shal, also contributes). Ectopic expression of isl, but not Lim3, is sufficient to reduce both Sh transcript and Sh current level. By contrast, coexpression of both TFs is additive, resulting in a significantly greater reduction in both Sh transcript and current compared with isl expression alone. These observations provide evidence for combinatorial activity of Isl and Lim3 in regulating ion channel gene expression. PMID:24523544

Large brown seaweeds of the British Isles: Evidence of changes in abundance over four decades

NASA Astrophysics Data System (ADS)

Yesson, Chris; Bush, Laura E.; Davies, Andrew J.; Maggs, Christine A.; Brodie, Juliet

2015-03-01

The large brown seaweeds (macroalgae) are keystone species in intertidal and shallow subtidal marine ecosystems and are harvested for food and other products. Recently, there have been sporadic, often anecdotal, reports of local abundance declines around the British Isles, but regional surveys have rarely revisited sites to determine possible changes. An assessment was undertaken of changes in the abundance of large brown seaweeds around the British Isles using historical survey data, and determination of whether any changes were linked with climate change. Data were analysed from multiple surveys for 14 habitat-forming and commercially important species of Phaeophyceae, covering orders Laminariales, Fucales and Tilopteridales. Changes in abundance were assessed for sites over the period 1974-2010. Trends in distribution were compared to summer and winter sea surface temperatures (SST). Results revealed regional patterns of both increase and decrease in abundance for multiple species, with significant declines in the south for kelp species and increases in northern and central areas for some kelp and wracks. Abundance patterns of 10 of the 14 species showed a significant association with SSTs, but there was a mixture of positive and negative responses. This is the first British Isles-wide observation of declining abundance of large brown seaweeds. Historical surveys provide useful data to examine trends in abundance, but the ad hoc nature of these studies limit the conclusions that can be drawn. Although the British Isles remains a stronghold for large brown algae, it is imperative that systematic surveys are undertaken to monitor changes.

Genomic evaluation, breed identification, and population structure of Guernsey cattle in North America, Great Britain, and the Isle of Guernsey

USDA-ARS?s Scientific Manuscript database

Genomic evaluations of dairy cattle in the United States have been available for Brown Swiss, Holsteins, and Jerseys since 2009 and for Ayrshire since 2013. As of January 2015, 2,263 Guernsey bulls and cows had genotypes from collaboration between the United States, Canada, England and the Isle of G...

Implementing a sustainable clinical supervision model for Isles nurses in Orkney.

PubMed

Hall, Ian

2018-03-02

The Isles Network of Care (INOC) community nurses work at the extreme of the remote and rural continuum, working mostly as lone practitioners. Following the development of sustainable clinical supervision model for Isles nurses in Orkney, clinical supervision was found to improve both peer support and governance for this group of isolated staff. A literature overview identified the transition of clinical supervision in general nursing over 24 years from 'carrot' to 'stick'. The study included a questionnaire survey that was sent to the 2017 Queen's Nursing Institute Scotland cohort to elicit information about the nurses' experience of clinical supervision. The survey found that 55% provide supervision and 40% receive it. Health board encouragement of its use was found to be disappointingly low at 40%. The INOC nurses were surveyed about the new peer-support (restorative) model, which relies on video-conference contact to allow face to face interaction between isolated isles nurses. Feedback prompted a review of clinical supervision pairings, and the frequency and methods of meeting. The need for supervisor training led to agreement with the Remote and Rural Health Education Alliance to provide relevant support. The perceived benefits of supervision included increased support and reflection, and improved relationships with isolated colleagues.

The Availability of Space Service for Inter-Satellite Links in Navigation Constellations

PubMed Central

Tang, Yinyin; Wang, Yueke; Chen, Jianyun

2016-01-01

Global navigation satellite systems (GNSS) are widely used in low Earth orbit (LEO) satellite navigation; however, their availability is poor for users in medium Earth orbits (MEO), and high Earth orbits (HEO). With the increasing demand for navigation from MEO and HEO users, the inadequate coverage of GNSS has emerged. Inter-satellite links (ISLs) are used for ranging and communication between navigation satellites and can also serve space users that are outside the navigation constellation. This paper aims to summarize their application method and analyze their service performance. The mathematical model of visibility is proposed and then the availability of time division ISLs is analyzed based on global grid points. The BeiDou navigation constellation is used as an example for numerical simulation. Simulation results show that the availability can be enhanced by scheduling more satellites and larger beams, while the presence of more users lowers the availability. The availability of navigation signals will be strengthened when combined with the signals from the ISLs. ISLs can improve the space service volume (SSV) of navigation constellations, and are therefore a promising method for navigation in MEO/HEO spacecraft. PMID:27548181

Cod Gadus morhua and climate change: processes, productivity and prediction.

PubMed

Brander, K M

2010-11-01

Environmental factors act on individual fishes directly and indirectly. The direct effects on rates and behaviour can be studied experimentally and in the field, particularly with the advent of ever smarter tags for tracking fishes and their environment. Indirect effects due to changes in food, predators, parasites and diseases are much more difficult to estimate and predict. Climate can affect all life-history stages through direct and indirect processes and although the consequences in terms of growth, survival and reproductive output can be monitored, it is often difficult to determine the causes. Investigation of cod Gadus morhua populations across the whole North Atlantic Ocean has shown large-scale patterns of change in productivity due to lower individual growth and condition, caused by large-scale climate forcing. If a population is being heavily exploited then a drop in productivity can push it into decline unless the level of fishing is reduced: the idea of a stable carrying capacity is a dangerous myth. Overexploitation can be avoided by keeping fishing mortality low and by monitoring and responding rapidly to changes in productivity. There are signs that this lesson has been learned and that G. morhua will continue to be a mainstay of the human diet. © 2010 The Author. Journal of Fish Biology © 2010 The Fisheries Society of the British Isles.

The use of an aeration system to prevent thermal stratification of a freshwater impoundment and its effect on downstream fish assemblages.

PubMed

Miles, N G; West, R J

2011-03-01

Warm-water riverine fish assemblages were investigated downstream of an impoundment before and after thermal stratification and the associated cold-water pollution was prevented using an aeration system. Temperatures below the dam significantly increased after installation of the aeration system and this correlated with an increased abundance and greater number of species downstream. Overall, aeration appeared to be beneficial for both the lake (upstream) and the downstream riverine environments. © 2011 The Authors. Journal of Fish Biology © 2011 The Fisheries Society of the British Isles.

Contour Digitizing and Tagging Software (CONTAGRID).

DTIC Science & Technology

1980-04-01

TYPE TO TYPE FROM # * DELETE TYPE #1 #, #1 #1 #, e JOYN TYPE #, # * REORDER TYPE #, #1 #1 TYPE = INDEX, NON, DEPRESSION, CUT, FILL, # NUMBER Figure B...ERRCOD.N’.0)C’ TO 8020 SIZE - IOR( IAN ;D(4ZOIFE,ISL(mJF(1),-7)), + lAND(4ZFEOO,ISL(BUr(1),9))) iF(SIZE.GT.390)GO TO 8030 LM- 0 DO 110 I-1,SIZE CALL

Wolf research in the Isle Royale wilderness: do the ends justify the means?

Treesearch

Jack G. Oelfke; Rolf O. Peterson; John A. Vucetich; Leah M. Vucetich

2000-01-01

Isle Royale National Park is a remote island ecosystem in Lake Superior. A long-term research program investigating the wolf and moose populations in the Park has provided the public and scientific community with valuable information on the ecology of these species in this wilderness setting. A persistent decline within the wolf population led to a change in the...

Short-range inverse-square law experiment in space

NASA Technical Reports Server (NTRS)

Strayer, D.; Paik, H. J.; Moody, M. V.

2002-01-01

The objective of ISLES (Inverse-Square Law Experiment in Space) is to perform a null test ofNewton's law on the ISS with a resolution of one part in lo5 at ranges from 100 pm to 1 mm. ISLES will be sensitive enough to detect axions with the strongest allowed coupling and to test the string-theory prediction with R z 5 pm.

Age, growth, and maturity of round whitefish of the Apostle Islands and Isle Royale Regions, Lake Superior

USGS Publications Warehouse

Bailey, Merryll M.

1963-01-01

The round whitefish has been of some commercial importance in the upper Great Lakes but production in Lake Superior has generally been small; the United States average was 26,600 pounds for 1929-59. This study is based on 1,173 fish collected in the Apostle Islands in 1958-60 and 103 collected at Isle Royale in 1958 and 1960. The average age of 6.0 years at Isle Royale was concluded to be significantly higher than the mean of 4.2 years in the Apostle Islands. The body-scale relation is a straight line with an intercept of 1.1 inches on the length axis. Weight of Apostle Islands round whitefish captured in several months increased as the 3.22 power of the length. Growth in length was relatively slow; nearly or fully 7 years were required to reach an acceptable commercial length of 14 inches in both the Apostle Islands and at Isle Royale. The calculated weights at the end of the seventh year were 12.6 ounces in the Apostle Islands and 13.8 ounces at Isle Royale. Minimum length at maturity of male round whitefish (7.0-7.4 inches) was less than that of females (8.5-8.9 inches). At age-group II, 11.1 percent of male round whitefish, but only 1.5 percent of the females were mature. All males were mature as age-group V and all females as age-group VI. Males dominated the younger age groups but females were more numerous in the older ones. Estimates of the number of eggs in 37 round whitefish ovaries yielded an average of 5,330 eggs for fish 10.5-17.4 inches long.

Assessing the British Isles CH4 flux using aircraft and ground-based sampling: a case study on 12 May 2015

NASA Astrophysics Data System (ADS)

Pitt, Joseph

2017-04-01

Aircraft and ground-based sampling of atmospheric greenhouse gas composition over the British Isles was conducted between 2014 and 2016 as part of the Greenhouse gAs UK and Global Emissions (GAUGE) project. We report a case study focussing on two research aircraft flights conducted on 12 May 2015 to sample inflow and outflow across the British Isles. We have employed the NAME Lagrangian dispersion model to simulate CH4 mole fraction enhancements corresponding to aircraft and ground-based sample times and locations, using CH4 surface fluxes derived from a composite flux inventory, which included both anthropogenic and natural sources. For each sampling location, variations in the baseline CH4 mole fraction were derived using the MOZART global chemical transport model, and added to the NAME enhancements to produce a dataset of modelled CH4 mole fractions which can be compared to the measurements. Using a multiple variable regression technique, we derive CH4 fluxes for the British Isles region from both aircraft and ground-based datasets. We discuss the applicability of our approach for both datasets, and conclude that in this case the assumptions inherent in our method are much better satisfied for the aircraft data than for the ground-based data. Using the aircraft data we derive a possible range of scale factors for the prior inventory flux of 0.53 - 0.97, with a central estimate of 0.82 based on our assessment of the most likely apportionment of model uncertainty. This leads to a posterior estimate of the British Isles CH4 flux of 67 kg s-1 - 121 kg s-1, with a central value of 103 kg s-1.

Cloud computing and validation of expandable in silico livers.

PubMed

Ropella, Glen E P; Hunt, C Anthony

2010-12-03

In Silico Livers (ISLs) are works in progress. They are used to challenge multilevel, multi-attribute, mechanistic hypotheses about the hepatic disposition of xenobiotics coupled with hepatic responses. To enhance ISL-to-liver mappings, we added discrete time metabolism, biliary elimination, and bolus dosing features to a previously validated ISL and initiated re-validated experiments that required scaling experiments to use more simulated lobules than previously, more than could be achieved using the local cluster technology. Rather than dramatically increasing the size of our local cluster we undertook the re-validation experiments using the Amazon EC2 cloud platform. So doing required demonstrating the efficacy of scaling a simulation to use more cluster nodes and assessing the scientific equivalence of local cluster validation experiments with those executed using the cloud platform. The local cluster technology was duplicated in the Amazon EC2 cloud platform. Synthetic modeling protocols were followed to identify a successful parameterization. Experiment sample sizes (number of simulated lobules) on both platforms were 49, 70, 84, and 152 (cloud only). Experimental indistinguishability was demonstrated for ISL outflow profiles of diltiazem using both platforms for experiments consisting of 84 or more samples. The process was analogous to demonstration of results equivalency from two different wet-labs. The results provide additional evidence that disposition simulations using ISLs can cover the behavior space of liver experiments in distinct experimental contexts (there is in silico-to-wet-lab phenotype similarity). The scientific value of experimenting with multiscale biomedical models has been limited to research groups with access to computer clusters. The availability of cloud technology coupled with the evidence of scientific equivalency has lowered the barrier and will greatly facilitate model sharing as well as provide straightforward tools for scaling simulations to encompass greater detail with no extra investment in hardware.

ISLES: Probing Extra Dimensions Using a Superconducting Accelerometer

NASA Technical Reports Server (NTRS)

Paik, Ho Jung; Moody, M. Vol; Prieto-Gortcheva, Violeta A.

2003-01-01

In string theories, extra dimensions must be compactified. The possibility that gravity can have large radii of compactification leads to a violation of the inverse square law at submillimeter distances. The objective of ISLES is to perform a null test of Newton s law in space with a resolution of one part in 10(exp 5) or better at 100 microns. The experiment will be cooled to less than or equal to 2 K, which permits superconducting magnetic levitation of the test masses. To minimize Newtonian errors, ISLES employs a near null source, a circular disk of large diameter-to-thickness ratio. Two test masses, also disk-shaped, are suspended on the two sides of the source mass at a nominal distance of 100 microns. The signal is detected by a superconducting differential accelerometer. A ground test apparatus is under construction.

In-Suit Light Exercise (ISLE) Prebreathe Protocol Peer Review Assessment. Part 2; Appendices

NASA Technical Reports Server (NTRS)

Brady, Timothy K.; Polk, James D.

2011-01-01

The performance of extravehicular activity (EVA) by National Aeronautics and Space Administration astronauts involves the risk of decompression sickness. This risk has been mitigated by the use of oxygen "prebreathe" to effectively wash out tissue nitrogen prior to each EVA. Now that the Space Shuttle Program (SSP) is being retired, high-pressure oxygen will become a limited resource. The In-Suit Light Exercise (ISLE) Prebreathe Protocol offers several potential benefits including its potential to save 6 pounds of oxygen per EVA. At the request of the NASA Engineering and Safety Center, the peer review convened on October 14, 2010. The major recommendation of the Review Committee was that the ISLE protocol was acceptable for operational use as a prebreathe option prior to EVA. The appendices to Volume I of the report are contained in this document.

In-Suit Light Exercise (ISLE) Prebreathe Protocol Peer Review Assessment. Volume 1

NASA Technical Reports Server (NTRS)

Brady, Timothy K.; Polk, James D.

2011-01-01

The performance of extravehicular activity (EVA) by National Aeronautics and Space Administration astronauts involves the risk of decompression sickness. This risk has been mitigated by the use of oxygen "prebreathe" to effectively wash out tissue nitrogen prior to each EVA. Now that the Space Shuttle Program (SSP) is being retired, high-pressure oxygen will become a limited resource. The In-Suit Light Exercise (ISLE) Prebreathe Protocol offers several potential benefits including its potential to save 6 pounds of oxygen per EVA. At the request of the NASA Engineering and Safety Center, the peer review convened on October 14, 2010. The major recommendation of the Review Committee was that the ISLE protocol was acceptable for operational use as a prebreathe option prior to EVA. The results from the peer review are contained in this document.

Annual Report of the Chief of Engineers, U.S. Army, on Civil Works Activities 1959

DTIC Science & Technology

1959-01-01

822, 093 Port of Sault Ste. Marie, Mich-------------------------------- 330, 764 Presque Isle Harbor, Mich -------------------------------- 3, 176, 834... Pennsylvania and West Virginia in July and August 1958 took 11 lives. Estimates indicate that in the Ohio Basin from Illinois to New York, in January and...operation Isle Au Haut Thoroughfare, Maine_ Cape Cod Canal (Onset Bay), Mass_ Gloucester Harbor (Lobster Cove), Mass. Newburyport Harbor, Mass

77 FR 4897 - Safety Zone; M/V Del Monte Live-Fire Gun Exercise, James River, Isle of Wight, VA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-01

...-AA00 Safety Zone; M/V Del Monte Live-Fire Gun Exercise, James River, Isle of Wight, VA AGENCY: Coast... provide for the safety of life on navigable waters during the live-fire gun exercises on the M/V Del Monte... associated with the live-fire gun exercise. DATES: This rule is effective in the CFR on February 1, 2012...

76 FR 31848 - Safety Zone; M/V Del Monte Live-Fire Gun Exercise, James River, Isle of Wight, Virginia

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-02

...-AA00 Safety Zone; M/V Del Monte Live-Fire Gun Exercise, James River, Isle of Wight, Virginia AGENCY... provide for the safety of life on navigable waters during the live-fire gun exercises on the M/V Del Monte... associated with the live-fire gun exercise. DATES: This rule will be effective from 11 a.m. June 6, 2011...

Camping impact management at Isle Royale National Park: An evaluation of visitor activity containment policies from the perspective of social conditions

Treesearch

Tracy A. Farrell; Jeffrey L. Marion

2000-01-01

A survey of backcountry and wilderness campsites at Isle Royale National Park reveals that the park’s policies for managing visitor impacts have been remarkably effective in limiting the areal extent of camping-related disturbance. However, the dense spatial arrangement of designated campsites within backcountry campgrounds has also contributed to problems with visitor...

Characterisation of a serotype O1 Yersinia ruckeri isolate from the Isle of Man: further evidence that O antigen serotype is not a reliable indicator of virulence

USDA-ARS?s Scientific Manuscript database

As part of a routine disease surveillance exercise, a culture of the Gram negative bacterial pathogen Yersinia ruckeri was obtained from one of 150 largely asymptomatic rainbow trout from a farm on the Isle of Man, an island off the North West coast of Great Britain. This is the first reported isol...

Food of young-of-the-year lake trout (Salvelinus namaycush) in Presque Isle Harbor, Lake Superior

USGS Publications Warehouse

Swedberg, Donald V.; Peck, James W.

1984-01-01

The food habits of young lake trout (Salvelinus namaycush) were studied by examining the digestive tracts of 293 young-of-the-year collected in Presque Isle Harbor, Lake Superior. Lake trout in the 25 to 27-mm length range started to eat food organisms before all of their yolk material was absorbed. Organisms consumed by the 25 to 27-mm young-of-the-year included Chironomidae, Copepoda (Harpacticoida, Calanoida, Cyclopoida), and Cladocerea (Daphnia spp., Bosmina sp., Chydorus sp.). Chironomid pupae and chironomid larvae accounted for 74% and 5%, respectively, of the total volume of food eaten by the young lake trout in Presque Isle Harbor. Although copepods, cladocerans, and mysids were present in many stomachs, their contribution to the total volume of food was only 15%. Some lake trout in the 32 to 54-mm length range had consumed fry of sculpin (Cottus spp.) or rainbow smelt (Osmerus mordax), but the overall contribution of fish fry to the total volume of food was only 4% (frequency of occurrence, 10%). The lake trout in Presque Isle Harbor fed heavily on planktonic organisms, sparingly on benthic organisms, and were opportunistic feeders that appeared to prey on whatever forage organisms were available in the shallow nearshore waters.

Production and Electrical Characterization Tests of the ISL Detector and a Trigger Design for Higgs Boson Searches at CDF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Munar Ara, Antoni

2002-01-01

This thesis is structured as follows: Chapter 1. gives a brief review of the Higgs mechanism in the Standard Model and the electroweak symmetry breaking. The Standard Model Higgs boson phenomenology at Tevatron energies is reviewed. Chapter 2. describes the upgraded Fermilab laboratory accelerator complex, and the upgraded CDF detector. Chapter 3. gives a brief overview of the more relevant aspects of the silicon detectors, and the ISL is described in detail. Chapter 4. describes the construction of the ISL ladders, the full custom testing setup (functionality tests, laser test, burn-in test andmore » $$\\beta$$-source measurements), and the problems encountered during the ISL ladders construction. The procedures for ladder grading are also discussed. Chapter 5. describes the multilevel trigger system of the CDF detector, and the trigger primitives available at each level. The most relevant offine event observables are briefly discussed. In Chapter 6 the procedures to estimate the trigger rate and trigger effciency calculation are described. The particularities of triggering in $$p\\bar{p}$$ collisions at high luminosities are discussed. Chapter 7. and Chapter 8. are dedicated to study an effcient trigger strategy for the $$H + W/Z \\to b\\bar{b}jj$$ channel and the $$H + Z \\to b\\bar{b} \

Lake Erie Water Level Study. Main Report.

DTIC Science & Technology

1981-07-01

of recreational beach activities. Examples include: Rondeau, Long Point and Sandbanks in Canada and Hamlin (New York), Presque Isle ( Pennsylvania ...be most affected by lake level changes. Long Point, Rondeau, Sandusky, and Presque Isle Bays are, due to their shallow nature and sand spit formation...AD-AI14 582 INTERNATIONAL LAKE ERIE REGULATION STUDY BOARD F/9 13/2 LAKE ERIE WATER LEVEL STUDY. MAIN REPORT.(U) UNCLASSIFIED N1.3 iE~hE

Population limitation and the wolves of Isle Royale

USGS Publications Warehouse

Peterson, Rolf O.; Thomas, Nancy J.; Thurber, Joanne M.; Vucetich, John A.; Waite, Thomas A.

1998-01-01

Population regulation for gray wolves in Isle Royale National Park, Michigan, was examined in 1987-1995 when wolves were in chronic decline following a crash of the population in 1981-1982. Canine parvovirus (CPV-2) was probably influential during the crash, but it disappeared by the late 1980s. High mortality abruptly ceased after 1988, but low recruitment in the absence of disease and obvious shortage of food prevented recovery of the wolf population. In 1983-1995, with a comparable number of moose '10 years old as potential prey, wolves were only half as numerous as in 1959-1980. A simulation of annual fluctuations in effective population size (Ne) for wolves on Isle Royale suggests that their genetic heterozygosity has declined ca. 13% with each generation and ca. 80% in the 50- year history of this population. Inbreeding depression and stochastic demographic variation both remain possible explanations for recent low recruitment.

Reconnaissance Study for the Western Lake Huron Basin, Watershed Study, Michigan, Section 905(b)

DTIC Science & Technology

2012-05-01

Isle, Alpena , Alcona, Iosco, Arenac, Bay, Tuscola, Huron, Sanilac, St. Clair, Midland, and Saginaw. With the exception of Midland and Saginaw Counties...Cheboygan, Presque Isle, Alpena , Alcona, Iosco, Arenac, Bay, Midland, Saginaw, Tuscola, Huron, Sanilac, and St. Clair. The study area includes the... Alpena Harbor. Alpena Harbor is at the mouth of the Thunder Bay River, which empties into Thunder Bay, Lake Huron. The harbor is 100 miles southeast of

Great Lakes and St. Lawrence Seaway Navigation Season Extension. Volume 6. Appendixes H - L

DTIC Science & Technology

1979-08-01

Great Lakes Shipping *Includes integrated tug-barge ’ Presque Isle " of 5Z.000 DWT. which. for operations purposes, is considered a vessel. As part of...Oniario, and Erie , Pennsylvania . Data collected from Under the National Oil and Haiardous Sub- these stations included solar radiation measurcments...individuals have As with other groups, they asked for more information 103 4 Presque Isle workv tender winter conditions. IM T 46! -- --qJ.,i~j

Great Lakes and St. Lawrence Seaway Navigation Season Extension. Volume 4. Appendixes D - F

DTIC Science & Technology

1979-08-01

the American additions Fort Presque Isle Rique Archaeological Somewhere unknown Palisaded Erie site within the princi- town destroyed by present city...7) 2.285 Rochester, New York (8) 2.173 Buffalo, New York (9) 2.520 Erie , Pennsylvania (10) 2.172 Cleveland, Ohio (68) 2.720 Toledo, Ohio (70) 2.370...Two Harbors, Duluth, Presque Isle , Marquette, Taconite, Silver Bay, Ashland, Escanaba, Port Dolomite, Port Inland, Drummond Island, other Lake

Erosional patterns of the Isles Dernieres, Louisiana, in relation to meteorological influences

USGS Publications Warehouse

Dingler, J.R.; Reiss, T.E.; Plant, N.G.

1993-01-01

Over the past 100 years, the Isles Dernieres, a low-lying barrier-island chain along the central Louisiana coast, has eroded extensively. This erosion has resulted in more than 1 km of northward beach-face retreat and the loss of 71% of the total island area. The primary causes for the erosion are wind and wave attack, diminished sand supply, and relative sea-level rise. Five years of detailed topographic surveys show that a beach on the central Isles Dernieres changed significantly in both shape and sediment volume; however, the pattern of change was not the same each year. In contrast to the relatively slow erosion caused by cold fronts, hurricane Gilbert, a category 5 hurricane that passed about 800 km south of the Isles Dernieres in September 1988, produced differential beach-face retreat of about 9 m at mean sea level and 40 m at an elevation of 0.5 m. Most of the sediment eroded from the beach face was deposited on the backshore, which resulted in only a small loss of sediment from the beach and a noteworthy decrease in beach-face slope. During the two years following hurricane Gilbert, the mean-sea-level contour remained stationary while the beach face slowly returned to its pre-Gilbert shape. "Cold-front' magnitude of retreat is expected to continue until another large hurricane alters the erosional pattern. -from Authors

Quantification of the indirect effects of scallop dredge fisheries on a brown crab fishery.

PubMed

Öndes, Fikret; Kaiser, Michel J; Murray, Lee G

2016-08-01

This study aimed to describe the characteristics of the by-catch of Cancer pagurus in king scallop dredges in the Isle of Man, and to determine the damage, immediate mortality and estimated mortality during fishing seasons associated with scallop dredges. Based on dredge surveys, spatial and seasonal variations were observed, with the highest number of crabs found off the west coast of the Isle of Man in the autumn when berried females crabs were most frequently caught. In general, female crabs comprised 84% of the catch. The damage levels of crabs was high with 45% of crabs recorded as crushed or dead or with severe damage, whilst 24% of crabs exhibited missing limbs. Estimates of the potential mortality associated with scallop dredging led to a lower and upper estimate of possible crab by-catch mortality of 15t and 24t respectively which represented 3.0-4.8% of the commercial landings of brown crab for the Isle of Man. Heaviest mortalities of crabs occurred in autumn to the west of the Isle of Man when female berried crabs move offshore into deeper water. The use of a temporary and spatially restricted scallop dredging closure could provide a simple solution to mitigate additional crab mortality in the event that scallop dredging increased beyond current levels in the future. Copyright © 2016 Elsevier Ltd. All rights reserved.

Impact of 1985 hurricanes on Isles Dernieres, Louisiana: Temporal and spatial analysis of coastal geomorphic changes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Debusshere, K.; Westphal, K.; Penland, S.

1989-09-01

Catastrophic geomorphic changes occurred in the Isles Dernieres barrier island arc as a result of the direct impact of three hurricanes in 1985. The severity of the impact of hurricanes Danny, Elena, and Juan had not been equaled since the landfall of hurricanes Betsy and Camille in the late 1960s. The Isles Dernieres had not been subjected to a direct hurricane landfall since hurricane Bob in 1979. The recent hurricane impacts provided the USGS/LGS Louisiana Cooperative Barrier Island and Land Loss Study the opportunity to examine the process-response characteristics of this low-profile transgressive barrier island arc to multiple hurricane impactsmore » in a single hurricane season. The geomorphic changes along the Isles Dernieres were determined using four sequential airborne videotape surveys acquired in July 1984, July 1985 (pre-storm), August 1985 (post-Danny) and November 1985 (post-Juan) and mapped on 1:24,000 base maps produced from concurrent vertical aerial photography. A coastal geomorphic classification was developed to describe, quantify, and map the alongshore geomorphic, sedimentologic , and vegetative character of this barrier shoreline. The classification consists of three levels of descriptors: (1) primary morphology to define the predominant longshore morphology, (2) modifiers to depict the small-scale longshore features, and (3) variants to locate and quantify important coastal features, not mappable at the scale used.« less

ExoMars Entry Demonstrator Module Dynamic Stability

NASA Astrophysics Data System (ADS)

Dormieux, Marc; Gulhan, Ali; Berner, Claude

2011-05-01

In the frame of ExoMars DM aerodynamics characterization, pitch damping derivatives determination is required as it drives the parachute deployment conditions. Series of free-flight and free- oscillation tests (captive model) have been conducted with particular attention for data reduction. 6 Degrees- of-Freedom (DoF) analysis tools require the knowledge of local damping derivatives. In general ground tests do not provide them directly but only effective damping derivatives. Free-flight (ballistic range) tests with full oscillations around trim angle have been performed at ISL for 0.5

Life history variation among four lake trout morphs at Isle Royale, Lake Superior

USGS Publications Warehouse

Hansen, Michael J.; Nate, Nancy A.; Muir, Andrew M.; Bronte, Charles R.; Zimmerman, Mara S.; Krueger, Charles C.

2016-01-01

Life history traits were compared among four morphs of lake trout at Isle Royale, Lake Superior. Of 738 lake trout caught at Isle Royale, 701 were assigned to a morph (119 humpers, 160 leans, 85 redfins, and 337 siscowets) using a combination of statistical analysis of head and body shape and visual assignment. On average, redfins were longer (544 mm), heavier (1,481 g), heavier at length (Wr = 94), more buoyant, and older (22 years) than siscowets (519 mm; 1,221 g; 90; 19 years), leans (479 mm; 854 g; 82; 13 years), and humpers (443 mm; 697 g; 87; 17 years). On average, leans grew from a younger age at length = 0 and shorter length at age = 0, at a faster early growth rate to a longer asymptotic length than the other three morphs, while redfins grew at a slower instantaneous rate and humpers grew to a shorter asymptotic length than other morphs. On average, leans were longer (562 mm) and older (15 years) at 50% maturity than redfins (427 mm, 12 years), siscowets (401 mm, 11 years), or humpers (394 mm, 13 years). Life history parameters did not differ between males and females within each morph. We conclude that differences in life history attributes of lean, humper, redfin, and siscowet morphs of lake trout are consistent with differential habitat use in waters around Isle Royale, Lake Superior.

General Review On The Investigations Conducted At Institute Saint-Louis (ISL) In The Field Of Holographic Nondestructive Testing

NASA Astrophysics Data System (ADS)

Smigielski, P.

1982-10-01

Among the various methods presently used in the field of nondestructive testing, optical holography is expected to become a very useful and promising tool in the near future. In fact, holography offers a number of advantages which should be briefly outlined here : direct and overall visualization of defects (disbonding, formation of cracks, inhomogeneities...) on large sufaces (of several square meters). Furthermore there is no interaction with the object under test and the surface to be studied has not to be treated. Finally holography is characterized by a high spatial resolution and a great sensitivity (it is possible to detect deformations as small as a few microns). In contrast to other modern techniques,holography is relatively unexpensive and can be used on-site with pulsed lasers. The general principles of holography and of methods using holographic interferometry will be recalled (double-exposure holographic interferometry, real-time holographic interferometry, "time-average" holographic interferometry). Thereafter the activities in which ISL is presently engaged will be reported briefly, that is laboratory feasibility tests and experiments conducted on-site in an industrial environment with the aid, in general, of pulsed ruby lasers : testing of adhesive bonding in solid propellant rockers and in aircraft structures, detection and observation of cracking in fatigue tests, visua-lization of the modes of vibration of mechanical structures, experiments conducted on air-craft subjected to maintenance checking, etc.

Optical data communication for Earth observation satellite systems

NASA Astrophysics Data System (ADS)

Fischer, J.; Loecherbach, E.

1991-10-01

The current development status of optical communication engineering in comparison to the conventional microwave systems and the different configurations of the optical data communication for Earth observation satellite systems are described. An outlook to future optical communication satellite systems is given. During the last decade Earth observation became more and more important for the extension of the knowledge about our planet and the human influence on nature. Today pictures taken by satellites are used, for example, to discover mineral resources or to predict harvest, crops, climate, and environment variations and their influence on the population. A new and up to date application for Earth observation satellites can be the verification of disarmament arrangements and the control of crises areas. To solve these tasks a system of Earth observing satellites with sensors tailored to the envisaged mission is necessary. Besides these low Earth orbiting satellites, a global Earth observation system consists of at least two data relay satellites. The communication between the satellites will be established via Inter-Satellite Links (ISL) and Inter-Orbit Links (IOL). On these links, bitrates up to 1 Gbit/s must be taken into account. Due to the increasing scarcity of suitable frequencies, higher carrier frequencies must probably be considered, and possible interference with terrestrial radio relay systems are two main problems for a realization in microwave technique. One important step to tackle these problems is the use of optical frequencies for IOL's and ISL's.

Cloud computing and validation of expandable in silico livers

PubMed Central

2010-01-01

Background In Silico Livers (ISLs) are works in progress. They are used to challenge multilevel, multi-attribute, mechanistic hypotheses about the hepatic disposition of xenobiotics coupled with hepatic responses. To enhance ISL-to-liver mappings, we added discrete time metabolism, biliary elimination, and bolus dosing features to a previously validated ISL and initiated re-validated experiments that required scaling experiments to use more simulated lobules than previously, more than could be achieved using the local cluster technology. Rather than dramatically increasing the size of our local cluster we undertook the re-validation experiments using the Amazon EC2 cloud platform. So doing required demonstrating the efficacy of scaling a simulation to use more cluster nodes and assessing the scientific equivalence of local cluster validation experiments with those executed using the cloud platform. Results The local cluster technology was duplicated in the Amazon EC2 cloud platform. Synthetic modeling protocols were followed to identify a successful parameterization. Experiment sample sizes (number of simulated lobules) on both platforms were 49, 70, 84, and 152 (cloud only). Experimental indistinguishability was demonstrated for ISL outflow profiles of diltiazem using both platforms for experiments consisting of 84 or more samples. The process was analogous to demonstration of results equivalency from two different wet-labs. Conclusions The results provide additional evidence that disposition simulations using ISLs can cover the behavior space of liver experiments in distinct experimental contexts (there is in silico-to-wet-lab phenotype similarity). The scientific value of experimenting with multiscale biomedical models has been limited to research groups with access to computer clusters. The availability of cloud technology coupled with the evidence of scientific equivalency has lowered the barrier and will greatly facilitate model sharing as well as provide straightforward tools for scaling simulations to encompass greater detail with no extra investment in hardware. PMID:21129207

Rayleigh wave tomography of the British Isles from ambient seismic noise

NASA Astrophysics Data System (ADS)

Nicolson, Heather; Curtis, Andrew; Baptie, Brian

2014-08-01

We present the first Rayleigh wave group speed maps of the British Isles constructed from ambient seismic noise. The maps also constitute the first surface wave tomography study of the crust under the British Isles at a relatively high resolution. We computed interferometric, interstation Rayleigh waves from vertical component records of ambient seismic noise recorded on 63 broad-band and short-period stations across the UK and Ireland. Group velocity measurements were made from the resulting surface wave dispersion curves between 5 and 25 s using a multiple phase-matched filter method. Uncertainties in the group velocities were computed by calculating the standard deviation of four dispersion curves constructed by stacking a random selection of daily cross-correlations. Where an uncertainty could not be obtained for a ray path using this method, we estimated it as a function of the interreceiver distance. Group velocity maps were computed for 5-25-s period using the Fast Marching forward solution of the eikonal equation and iterative, linearized inversion. At short and intermediate periods, the maps show remarkable agreement with the major geological features of the British Isles including: terrane boundaries in Scotland; regions of late Palaeozoic basement uplift; areas of exposed late Proterozoic/early Palaeozoic rocks in southwest Scotland, northern England and northwest Wales and, sedimentary basins formed during the Mesozoic such as the Irish Sea Basin, the Chester Basin, the Worcester Graben and the Wessex Basin. The maps also show a consistent low-velocity anomaly in the region of the Midlands Platform, a Proterozoic crustal block in the English Midlands. At longer periods, which are sensitive velocities in the lower crustal/upper mantle, the maps suggest that the depth of Moho beneath the British Isles decreases towards the north and west. Areas of fast velocity in the lower crust also coincide with areas thought to be associated with underplating of the lower crust such as Northern Ireland, the eastern Irish Sea and northwest Wales.

Accuracy evaluation of distance inverse square law in determining virtual electron source location in Siemens Primus linac.

PubMed

Douk, Hamid Shafaei; Aghamiri, Mahmoud Reza; Ghorbani, Mahdi; Farhood, Bagher; Bakhshandeh, Mohsen; Hemmati, Hamid Reza

2018-01-01

The aim of this study is to evaluate the accuracy of the inverse square law (ISL) method for determining location of virtual electron source ( S Vir ) in Siemens Primus linac. So far, different experimental methods have presented for determining virtual and effective electron source location such as Full Width at Half Maximum (FWHM), Multiple Coulomb Scattering (MCS), and Multi Pinhole Camera (MPC) and Inverse Square Law (ISL) methods. Among these methods, Inverse Square Law is the most common used method. Firstly, Siemens Primus linac was simulated using MCNPX Monte Carlo code. Then, by using dose profiles obtained from the Monte Carlo simulations, the location of S Vir was calculated for 5, 7, 8, 10, 12 and 14 MeV electron energies and 10 cm × 10 cm, 15 cm × 15 cm, 20 cm × 20 cm and 25 cm × 25 cm field sizes. Additionally, the location of S Vir was obtained by the ISL method for the mentioned electron energies and field sizes. Finally, the values obtained by the ISL method were compared to the values resulted from Monte Carlo simulation. The findings indicate that the calculated S Vir values depend on beam energy and field size. For a specific energy, with increase of field size, the distance of S Vir increases for most cases. Furthermore, for a special applicator, with increase of electron energy, the distance of S Vir increases for most cases. The variation of S Vir values versus change of field size in a certain energy is more than the variation of S Vir values versus change of electron energy in a certain field size. According to the results, it is concluded that the ISL method can be considered as a good method for calculation of S Vir location in higher electron energies (14 MeV).

Great Lakes/St. Lawrence Seaway Regional Transportation Study; Great Lakes Area Industries.

DTIC Science & Technology

1981-11-01

integrated mill at Nanticoke on Lake Erie , directly north of Erie , Pennsylvania . Almost all iron ore is received at these plants by water. 111-23II Ia...Generating Co. Decker, MT 613 Presque Isle Plant (MI) Absaloka, MT 307 Roseloud, MT 307 Pevler, KY 301 Wolverine, KY 192 All Sources 2120 Note...Pub. Works Holland, MI 160 Grand Haven Bd. of L&P Grand Haven, MI 90 Marquette Bd. of L&P Marquette, MI 125 Upper Penin. Gen. Co. Presque Isle

Henry Bouquet: a Study of Three Military Campaigns in North America, 1758-1764

DTIC Science & Technology

1991-06-07

blocking the English westward advancement.1 3 By the fall of 1753 the French succeeded in establishing three forts, one at Presqu ’ Isle , on the south...side of Lake Erie , near present Erie , Pennsylvania , a second at Le Boeuf, present Waterford, Pennsylvania , and a third at Venango, Pennsylvania . (See...another detachment under De Lignery traveled overland north to the French forts of Venango and Presque ’ Isle . 4 8 The victory had come none too

Requirements for Information/Education Programs on Hypothermia.

DTIC Science & Technology

1979-10-23

NY (NBC) WEZF - Burlington, VT (ABC) Bangor, ME: 112,800 WLBZ - Bangor, ME (NBC) WABI - Bangor, ME (CBS) WVII - Bangor, ME (ABC) Presque Isle , ME...28,700 WAGM - Presque Isle , ME CBS(ABC-NBC) A-2 MID-ATLANTIC: 18,885,600 New York, NY: 6,375,500 Raleigh-Durham, NC: 451,800 WCBS - New York, NY (CBS...NY (ABC) WICZ - Binghamton, NY (NBC) WilingonNC: 135,300 WWAY -IWilmington, NC (ABC) WECT - Wilmington, NC NBC (CBS) Erie , PA: 132,600 WICU - Erie , PA

Buffalo Harbor Study. Preliminary Feasibility Report. Volume II. Appendices.

DTIC Science & Technology

1983-04-01

699,342:2,382,250:2,581,741: 88 332 :Silver Bay, HN 593,609: 151,635: - : - : :Escanaba, MI :550,189: - : - : - : : Presque Isle , MI : 25,245... PRESQUE ISLE 1,000.0 Self Unloader 1973 ROESCH, WILLIAM R. 630.0 Self Unloader 1973 THAYER, PAUL . 630.0 Self Unloader 1973 WILSON, CHARLES E. 680.0 Self...of Deep Water Wave Angle Classes A3 Frequency Curve for Annual Mean Levels of Lake Erie A4 Frequency of Occurrence of Short Period Fluctuations on

Distribution of Personnel by State-by Installation, FY-62

DTIC Science & Technology

1962-06-30

Strategic-Air Defense) 6,125 46 5,693 46 432 43 Presque Isle AFB (Missile) 59 * 13 * 46 4 Subtotal 1,832 11,023 890 STATE TOTAL 1332 100 12&326 100...49 eOklahoa . . . . . . . . . . . .......... . . . 52 e Oregon s . . . . . . . . . . . . . . . . . 53 Pennsylvania ...631 6 631 33 0 0 Subtotal 9 A 1,705 7,594 91 STATE TOTAL 10.234 100 1,914 100 8lo010 ___ I 0___ io l~O - NAVY Grosse Isle NAS 732 60 644 56 88 68

The Caribbean Basin: A Climatological Study

DTIC Science & Technology

1989-12-01

40 to200 km). A ridge in the center of theislanrises toI 1,017 feet (310 meters), but most of the island is mangrove swamp. The Isle of Pines (or Isle...The highest port of Plymouth . The southern range rises to 3,000 feet (914 point is 669 feet (204 meters). meters) in the Soufriere Hills. LES SAINTES...and de Margarita aft. from west to est: Islas de Ayes, Islas Ins barren . r; -ing from sea level to 617 feet (188 metes). Roques. La Orchila, Isla Is

Ground water for public water supply at Windigo, Isle Royale National Park, Michigan

USGS Publications Warehouse

Grannemann, N.G.; Twenter, F.R.

1982-01-01

Three test holes drilled at Windigo in Isle Royale National Park in 1981 indicate that the ophitic basaltic lava flows underlying the area contain little water and cannot be considered a source for public water supply. The holes were 135, 175, and 71 feet deep. One hole yielded about 1 gallon of water perminute; the other two yielded less. Glacial deposits seem to offer the best opportunity for developing a ground-water supply of 5 to 10 gallons per minute.

Imaging a fossil oolitic system with GPR, insights into the exposures of the Isle of Portland (UK)

NASA Astrophysics Data System (ADS)

Moreau, Julien; Hansen, Trine L.; Nielsen, Lars

2015-04-01

The Isle of Portland shows exposure of uppermost Jurassic oolitic carbonate all along its coast. The stone of Portland properties are famous as standards for concrete composition, as building material but also for sculpture. As a consequence, the Isle has been quarried intensively for hundreds of years. The regional exposure quality is very high with a potential 3D control. The site has seen generations of geologist trainees coming for field work. The Wessex Basin where the Isle is sitting contains an active petroleum system and the geologists visiting/training there use the carbonates of Portland as an analogue to equivalent Middle-East oil and gas reservoir. Surprisingly, although the site has a tremendous potential to understand the 3D architecture and the sedimentary dynamic of an oolitic system, only punctual observations of logs (1D), sometimes correlated have been published. Several studies place a shore line between the Isle and the continent striking NEE-SWW and facing towards the Channel. Facies changes are attributed to rapid sea-level variations and Walter's Law. We have collected an extensive GPR survey of the same stratigraphic interval (The Portland Freestone). With a total of 99 GPR profiles, we have produced grids on top of most of the coastal cliffs and quarry faces. We have encountered 3 main architectures: 2-m-high bars with steep clinoforms, 10s of metres-wide channels plugged with a variety of organisms and stacked aggrading bundles of multidirectional dunesets. Our dataset does not illustrate any major unconformity which could be attributed to a sharp sea-level drop. We have interpreted our sedimentary architecture to be the result of various hydrodynamic conditions associated with a mix of wave and tide influences. The Isle shows an island barrier complex which progrades into the basin but also expands laterally filling up the available space and cannibalising itself. More proximal facies are effectively observed in the north of the island towards the former continent or lagoon. However, the survey clearly shows that the shore zone progrades broadly towards the SW, partially away from the channel, at > 90 deg. from the former reconstructions. This result suggests as we know that the Channel contain deeper facies that the oolitic shore zone system must form a large spit platform, pointing south. Illustrating a contorted and complex shoreline/barrier, contrasting with the former cylindrical view of the depositional system. The combination of sedimentology and geophysics allowed to reevaluate the depositional system of the Isle of Portland oolitic deposits. It also challenges the sea-level reconstruction of this interval and the palaeogeographic reconstructions in the basin by showing shoreline trajectories. The multidisciplinary approach permitted to view and analyse a Jurassic depositional system almost alike what can be done on active oolitic systems. The approach has a tremendous potential to better understand cliff exposures and in particular to produce analogues of hydrocarbon reservoirs.

Shyness and boldness differences across contexts in juvenile three-spined stickleback Gasterosteus aculeatus from an anadromous population.

PubMed

Dzieweczynski, T L; Crovo, J A

2011-09-01

To examine if a behavioural syndrome is present in juvenile three-spined stickleback Gasterosteus aculeatus from anadromous populations, individuals were repeatedly exposed to a variety of conditions to assess behavioural consistency and determine if a shyness-boldness syndrome occurred. The degree of exploration in a novel environment was positively correlated with boldness in all other test conditions. Activity level in all contexts, foraging, predator inspection and shoaling were found to be repeatable while other behaviours such as latency to respond appeared more plastic. Both similarities and differences were found for behavioural correlations within and across contexts when compared to prior studies on freshwater populations of G. aculeatus. This suggests that selection pressures may vary across ontogeny and environments. © 2011 The Authors. Journal of Fish Biology © 2011 The Fisheries Society of the British Isles.

Redescription of Strombidium oculatum Gruber 1884 (Ciliophora, Oligotrichia).

PubMed

Montagnes, David J S; Lowe, Chris D; Poultonb, Alex; Jonsson, Per R

2002-01-01

The marine, tide pool-dwelling ciliate Stombidium oculatum was redescribed using live, stained, SEM, and TEM material prepared from samples collected from pools on the Isle of Man (Irish Sea) and Brittany (France). Also, we reviewed the older German and French works that reported on ciliates collected in the Mediterranean and Brittany, respectively. The Brittany and Isle of Man populations of the ciliate were considered identical. Some morphological and behavioural differences exist between the Brittany-Isle of Man populations and the Mediterranean populations, but they were insufficient to distinguish different taxa. Thus, taxa from all three locations were considered to be conspecific. Key features used to describe the ciliate were: morphology and ultrastructure of the free-swimming ciliate; cyst morphology; presence of mixotrophic-chloroplasts; presence of an eye spot composed of stigma obtained from chlorophyte prey; division, morphogenesis, and nuclear structure; live observations and behaviour, including the encystment-excystment cycle. Based on morphological and behavioural characteristics the taxon was distinguished from other similar species, and a neotype has been designated as no type material exists.

Tidal inlet development and migration in Isles Dernieres Barrier Island Arc, Louisiana

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jaffe, B.E.; Sallenger, A.H.; List, J.H.

The Isles Dernieres barrier arc formed about 420 years ago in response to the abandonment of the Bayou Petit Caillou delta of the Mississippi River. Over the past 100 years, the arc has undergone rapid erosion, with much of the Gulf shorelines retreating more than 1 km (10 m/year). Today, the island area is less than 25% of what it was 100 years ago. Most of this areal loss is from a narrowing of the islands as both the bay and Gulf shorelines retreated. A significant portion, however, is due to development of two large tidal inlets that segmented themore » 32 km long arc into three groups of islands from what was a nearly continuous island in 1890. The presence of these inlets and two recently formed smaller ones alters longshore transport and island erosion patterns. To predict the future of the Isles Dernieres, the authors must understand the history and processes of tidal inlet development.« less

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis.

PubMed

Pathania, Rajneesh; Ramachandran, Sabarish; Elangovan, Selvakumar; Padia, Ravi; Yang, Pengyi; Cinghu, Senthilkumar; Veeranan-Karmegam, Rajalakshmi; Arjunan, Pachiappan; Gnana-Prakasam, Jaya P; Sadanand, Fulzele; Pei, Lirong; Chang, Chang-Sheng; Choi, Jeong-Hyeon; Shi, Huidong; Manicassamy, Santhakumar; Prasad, Puttur D; Sharma, Suash; Ganapathy, Vadivel; Jothi, Raja; Thangaraju, Muthusamy

2015-04-24

Mammary stem/progenitor cells (MaSCs) maintain self-renewal of the mammary epithelium during puberty and pregnancy. DNA methylation provides a potential epigenetic mechanism for maintaining cellular memory during self-renewal. Although DNA methyltransferases (DNMTs) are dispensable for embryonic stem cell maintenance, their role in maintaining MaSCs and cancer stem cells (CSCs) in constantly replenishing mammary epithelium is unclear. Here we show that DNMT1 is indispensable for MaSC maintenance. Furthermore, we find that DNMT1 expression is elevated in mammary tumours, and mammary gland-specific DNMT1 deletion protects mice from mammary tumorigenesis by limiting the CSC pool. Through genome-scale methylation studies, we identify ISL1 as a direct DNMT1 target, hypermethylated and downregulated in mammary tumours and CSCs. DNMT inhibition or ISL1 expression in breast cancer cells limits CSC population. Altogether, our studies uncover an essential role for DNMT1 in MaSC and CSC maintenance and identify DNMT1-ISL1 axis as a potential therapeutic target for breast cancer treatment.

United States Air Force Statistical Digest (Abridged), Fiscal Year 1991 Estimate

DTIC Science & Technology

1990-01-01

AS OF: 30 APRIL 1990 0 USAF ACTIVE INSTALLATIONS m I.I.l IV FIGURE E-6 •..•o , ••o MARIANA ISLS 8 GUAM c.e ANDERSEN AFB o o o ,. BONIN ISLS o o o...Byron, Beverly B. (MD) Mavroules, Nicholas (MA) Hutto, Earl D. (Fl) Skelton, Ike (MO) leath, Marvin (TX) McCurdy, Dave (OK) Foglletta, T.M. (PA) Dyson...34 ’: :..:;"’, :.;..: ’ "".:.:..’:.::.’. DEMOCRATS Dellums, Ronald (CA) Chmn. McCurdy, Dave (OK) Foglletta, Thomas (PA) Hertel, Dennis (MI) Darden, George

List of Publications of the US Army Engineer Waterways Experiment Station. Volume 1.

DTIC Science & Technology

1986-12-01

Leo R 3-06 Feb 1960 Factors Affectin6 Beach Nourishment Requirements, AD 631 520 Presque Isle Peninsula, Erie , Pennsylvania , by D. W. Berg H 4-66 Jun...962 Pressures TM 3-377 Jan 1954 Heat and Blast Effects on Tar and Tar-Rubber Pavements, AD 030 247 Presque Isle Air Force Base, Maine TM 3-379...G. Aubrev, and J. Karpen MR 80-10 Nov 1980 Sand Resources of Southern Lake Erie , Conneaut to AD A097 984 Toledo, Ohio - A Seismic Reflection and

An Avatar-Based Italian Sign Language Visualization System

NASA Astrophysics Data System (ADS)

Falletto, Andrea; Prinetto, Paolo; Tiotto, Gabriele

In this paper, we present an experimental system that supports the translation from Italian to Italian Sign Language (ISL) of the deaf and its visualization through a virtual character. Our objective is to develop a complete platform useful for any application and reusable on several platforms including Web, Digital Television and offline text translation. The system relies on a database that stores both a corpus of Italian words and words coded in the ISL notation system. An interface for the insertion of data is implemented, that allows future extensions and integrations.

A Lower Carboniferous two-stage extensional basin along the Avalon-Meguma terrane boundary: Evidence from southeastern Isle Madame, Nova Scotia

USGS Publications Warehouse

Force, E.R.; Barr, S.M.

2006-01-01

Anomalously thick and coarse clastic sedimentary successions, including over 5000 m of conglomerate, are exposed on Isle Madame off the southern coast of Cape Breton Island. Two steeply to moderately dipping stratigraphic packages are recognized: one involving Horton and lower Windsor groups (Tournasian-Visean); the other involving upper Windsor and Mabou (Visean-Namurian) groups. Also anomalous on Isle Madame are three long narrow belts of "basement" rocks, together with voluminous chloritic microbreccia and minor semi-ductile mylonite, which are separated from the conglomerate-dominated successions by faults. The angular relations between the cataclastic rocks and the conglomerate units, combined with the presence of cataclasite clasts in the conglomerate units and evidence of dip-slip faults within the basin, suggest an extensional setting, where listric normal faults outline detachment allochthons. Allochthon geometry requires two stages of extension, the older stage completed in early Windsor Group time and including most of the island, and the more local younger stage completed in Mabou Group time. Domino-style upper-plate faulting in the younger stage locally repeated the older detachment relation of basement and conglomerate to form the observed narrow belts. Re-rotation of older successions in the younger stage also locally overturned the Horton Group. These features developed within a broad zone of Carboniferous dextral transcurrent faulting between already-docked Avalon and Meguma terranes. Sites of transpression and transtension alternated along the Cobequid-Chedabucto fault zone that separated these terranes. The earlier extensional features in Isle Madame likely represent the northern headwall and associated clastic debris of a pull-apart or other type of transtensional basin developed along part of this fault zone that had become listric; they were repeated and exposed by being up-ended in the second stage of extension, also on listric faults. The two-stage history on Isle Madame exposes the deeper parts of one of the Horton-age extensional basins of the Maritimes, others of which have been described as half-grabens based on their shallower exposures.

Nearshore habitat and fish community associations of coaster brook trout in Isle Royale, Lake Superior

USGS Publications Warehouse

Gorman, O.T.; Moore, S.A.; Carlson, A.J.; Quinlan, H.R.

2008-01-01

We characterized the nearshore habitat and fish community composition of approximately 300 km of shoreline within and adjacent to the major embayments of Isle Royale, Lake Superior. Sampling yielded 17 species, of which 12 were widespread and represented a common element of the Lake Superior fish community, including cisco Coregonus artedi, lake whitefish C. clupeaformis, round whitefish Prosopium cylindraceum, lake trout Salvelinus namaycush, rainbow smelt Osmerus mordax, lake chub Couesius plumbeus, longnose sucker Catostomus catostomus, white sucker C. commersonii, trout-perch Percopsis omiscomaycus, ninespine stickleback Pungitius pungitius, burbot Lota lota, and slimy sculpin Cottus cognatus. The presence of brook trout S. fontinalis in an embayment was associated with the common species of the Isle Royale nearshore fish community, particularly cisco, longnose sucker, and round whitefish. However, brook trout were present in only five embayments and were common only in Tobin Harbor. Most Isle Royale embayments had broadly overlapping ranges of nearshore habitats. Within embayments, fish were distributed along a habitat gradient from less-protected rocky habitat near the mouth to highly protected habitat with mixed and finer substrates at the head. Embayments with brook trout had greater mean protection from the open lake, greater variation in depth, greater mean cover, and higher mean frequencies of large substrates (cobble, boulder, and bedrock). Within those embayments, brook trout were associated with habitat patches with higher mean frequencies of small substrates (particularly sand and coarse gravel). Within Tobin Harbor, brook trout were associated with midembayment habitat and species assemblages, especially those locations with a mixture of sand, gravel, and cobble substrates, an absence of bedrock, and the presence of round whitefish, white sucker, and trout-perch. Comparison of embayments with the model, Tobin Harbor, showed that six embayments without brook trout had very similar arrays of habitat. However, four embayments with brook trout had relatively different arrays of habitat from Tobin Harbor. These results suggest that there is potential for further recovery of brook trout populations across Isle Royale nearshore habitats. ?? Copyright by the American Fisheries Society 2008.

Networked localization of sniper shots using acoustics

NASA Astrophysics Data System (ADS)

Hengy, S.; Hamery, P.; De Mezzo, S.; Duffner, P.

2011-06-01

The presence of snipers in modern conflicts leads to high insecurity for the soldiers. In order to improve the soldier's protection against this threat, the French German Research Institute of Saint-Louis (ISL) initiated studies in the domain of acoustic localization of shots. Mobile antennas mounted on the soldier's helmet were initially used for real-time detection, classification and localization of sniper shots. It showed good performances in land scenarios, but also in urban scenarios if the array was in the shot corridor, meaning that the microphones first detect the direct wave and then the reflections of the Mach and muzzle waves. As soon as the acoustic arrays were not near to the shot corridor (only reflections are detected) this solution lost its efficiency and erroneous estimated position were given. In order to estimate the position of the shooter in every kind of urban scenario, ISL started studying time reversal techniques. Knowing the position of every reflective object in the environment (buildings, walls, ...) it should be possible to estimate the position of the shooter. First, a synthetic propagation algorithm has been developed and validated for real scale applications. It has then been validated for small scale models, allowing us to test our time reversal based algorithms in our laboratory. In this paper we discuss all the challenges that are induced by the application of sniper detection using time reversal techniques. We will discuss all the hard points that can be encountered and try to find some solutions in order to optimize the use of this technique.

Improved age constraints for the retreat of the Irish Sea Ice Stream

NASA Astrophysics Data System (ADS)

Smedley, Rachel; Chiverrell, Richard; Duller, Geoff; Scourse, James; Small, David; Fabel, Derek; Burke, Matthew; Clarke, Chris; McCarroll, Danny; McCarron, Stephen; O'Cofaigh, Colm; Roberts, David

2016-04-01

BRITICE-CHRONO is a large (> 45 researchers) consortium project working to provide an extensive geochronological dataset constraining the rate of retreat of a number of ice streams of the British-Irish Ice Sheet following the Last Glacial Maximum. When complete, the large empirical dataset produced by BRITICE-CHRONO will be integrated into model simulations to better understand the behaviour of the British-Irish Ice Sheet in response to past climate change, and provide an analogue for contemporary ice sheets. A major feature of the British-Irish Ice Sheet was the dynamic Irish Sea Ice Stream, which drained a large proportion of the ice sheet and extended to the proposed southern limit of glaciation upon the Isles of Scilly (Scourse, 1991). This study will focus on a large suite of terrestrial samples that were collected along a transect of the Irish Sea basin, covering the line of ice retreat from the Isles of Scilly (50°N) in the south, to the Isle of Man (54°N) in the north; a distance of 500 km. Ages are determined for both the eastern and western margins of the Irish Sea using single-grain luminescence dating (39 samples) and terrestrial cosmogenic nuclide dating (10 samples). A Bayesian sequence model is then used in combination with the prior information determined for deglaciation to integrate the geochronological datasets, and assess retreat rates for the Irish Sea Ice Stream. Scourse, J.D., 1991. Late Pleistocene stratigraphy and palaeobotany of the Isles of Scilly. Philosophical Transactions of the Royal Society of London B334, 405 - 448.

Optimization of the Medium for the Production of Extracellular Amylase by the Pseudomonas stutzeri ISL B5 Isolated from Municipal Solid Waste

PubMed Central

Dutta, Prajesh; Deb, Akash

2016-01-01

The management of municipal solid waste is one of the major problems of the present world. The use of microbial enzymes for sustainable management of the solid waste is the need of the time. In the present study, we have isolated a potent amylase producing strain (ISL B5) from municipal solid waste. The strain was identified as Pseudomonas stutzeri (P. stutzeri) both biochemically and by 16S rDNA sequencing. The optimization studies revealed that the strain ISL B5 exhibited maximum activity in the liquid media containing 2% starch (2.77 U/ml), 0.8% peptone (2.77 U/ml), and 0.001% Ca2+ ion (2.49 U/ml) under the pH 7.5 (2.59 U/ml), temperature 40°C (2.63 U/ml), and 25 h of incubation period (2.49 U/ml). The highest activity of crude enzyme has also been optimized at the pH 8 (2.49 U/ml). PMID:28096816

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

PubMed Central

Pathania, Rajneesh; Ramachandran, Sabarish; Elangovan, Selvakumar; Padia, Ravi; Yang, Pengyi; Cinghu, Senthilkumar; Veeranan-Karmegam, Rajalakshmi; Arjunan, Pachiappan; Gnana-Prakasam, Jaya P.; Fulzele, Sadanand; Pei, Lirong; Chang, Chang-Sheng; Choi, Hyeon; Shi, Huidong; Manicassamy, Santhakumar; Prasad, Puttur D.; Sharma, Suash; Ganapathy, Vadivel; Jothi, Raja; Thangaraju, Muthusamy

2015-01-01

Mammary stem/progenitor cells (MaSCs) maintain self-renewal of the mammary epithelium during puberty and pregnancy. DNA methylation provides a potential epigenetic mechanism for maintaining cellular memory during self-renewal. Although DNA methyltransferases (DNMTs) are dispensable for embryonic stem cell maintenance, their role in maintaining MaSCs and cancer stem cells (CSCs) in constantly replenishing mammary epithelium is unclear. Here we show that DNMT1 is indispensable for MaSC maintenance. Furthermore, we find that DNMT1 expression is elevated in mammary tumors, and mammary gland-specific DNMT1 deletion protects mice from mammary tumorigenesis by limiting the CSC pool. Through genome-scale methylation studies, we identify ISL1 as a direct DNMT1 target, hypermethylated and downregulated in mammary tumors and CSCs. DNMT inhibition or ISL1 expression in breast cancer cells limits CSC population. Altogether, our studies uncover an essential role for DNMT1 in MaSC and CSC maintenance and identify DNMT1-ISL1 axis as a potential therapeutic target for breast cancer treatment. PMID:25908435

Optical intersatellite links - Application to commercial satellite communications

NASA Technical Reports Server (NTRS)

Paul, D.; Faris, F.; Garlow, R.; Inukai, T.; Pontano, B.; Razdan, R.; Ganz, Aura; Caudill, L.

1992-01-01

Application of optical intersatellite links for commercial satellite communications services is addressed in this paper. The feasibility of commercialization centers around basic issues such as the need and derived benefits, implementation complexity and overall cost. In this paper, commercialization of optical ISLs is assessed in terms of the services provided, systems requirements and feasibility of appropriate technology. Both long- and short-range ISLs for GEO-GEO, GEO-LEO and LEO applications are considered. Impact of systems requirements on the payload design and use of advanced technology in reducing its mass, power, and volume requirements are discussed.

Pulsed Holographic Nondestructive Testing On Aircraft

NASA Astrophysics Data System (ADS)

Fagot, Hubert; Smigielski, Paul; Albe, Felix; Arnaud, Jean-Louis

1983-06-01

An holographic camera composed of two ruby lasers was built at ISL. It provides double exposure holograms with an adjustable time interval ranging from few ns to infinity. Various aircraft structures were first tested at ISL in laboratory conditions: honeycomb panels, wings ... The industrial tests on a military aircraft in maintenance checking were performed in a hangar of the SNIAS at Saint-Nazaire: wings, trap-door of the rear landing gear, air-brake... Electromechanical shocks were used to make the structure vibrate and to allow a fast trigger of the lasers. This avoids disturbance due to ambiant noises and vibrations.

List of Publications of the U.S. Army Engineer Waterways Experiment Station. Volume 2

DTIC Science & Technology

1990-06-01

Presque Isle AD A135 394 Beaches, Erie , Pennsylvania ; Hydraulic Model Investi- gation, by W. C. Seabergh TR HL-83-16 Columbia River Estuary Hybrid Model...November 1982 NP EL-68 Presque Isle , Pennsylvania TR CERC-89-3 CERC-17 17-19 October 1983 MP EL-68 Beaches TR HL-83-15 HL-1i 30-31 October 1984 NP EL-68...AD A208 528 Peninsula, Erie , Pennsylvania , by P. J. Grace TR CERC-89-4 May 1989 Stability of Stone- and Dolos-Armored Rubble-Mound AD A208 527

Lorain Harbor, Ohio. Preliminary Feasibility Study (Stage 2). Review of Reports. Volume II. Appendices.

DTIC Science & Technology

1980-10-01

looked all the way from the west to all the way down to Erie , Pennsylvania . We made some initial cuts and got it down to five different ports...Harbor, MN Presque Isle :Two Harbors, MN :Gary, IN 1,721,920 25 (Litton Great Lakes):Two Harbors, MN :Calumet Harbor, IN 178,080 3 :Two Harbors, MN...WI : 2 :11 : 0: 0 : 0: 2: 3 Silver Bay, MN : 82 :67 : 96 :87 : 85 : 88: 89 Taconite, MN : 0 : 0 : 0: 0 : 0: 4: 0 Presque Isle , MI : 6 2 : 1 0.5: 2 1

Preliminary clinical results with the ISL laser

NASA Astrophysics Data System (ADS)

Hoppeler, Thomas; Gloor, Balder

1992-08-01

The ISL laser (Intelligent Surgical Lasers, Inc.), a Nd:YLF picosecond pulse laser, is currently being used under investigational device exemption to perform microsurgery of the anterior segment of the eye. At different study sites procedures for cataract fragmentation and iridotomy, as well as for posterior capsulotomy after cataract surgery, are under evaluation. Other potential applications include: sclerostomy ab interno, the cutting of membranes in the anterior and posterior segment of the eye; corneal incisions; and corneal intrastromal effects. We discuss various clinically relevant aspects of the use of this picosecond laser. An overview of different computer controlled laser patterns is given.

Stress and welfare in ornamental fishes: what can be learned from aquaculture?

PubMed

Stevens, C H; Croft, D P; Paull, G C; Tyler, C R

2017-08-01

The ornamental fish trade is estimated to handle up to 1·5 billion fishes. Transportation and handling of fishes imposes a range of stressors that can result in mortality at rates of up to 73%. These rates vary hugely, however, and can be as low as 2%, because they are generally estimated rather than based on experimental work. Given the numbers of ornamental fishes traded, any of the estimated mortality rates potentially incur significant financial losses and serious welfare issues. Industry bodies, such as the Ornamental Aquatic Trade Association (OATA), have established standards and codes of best practice for handling fishes, but little scientific research has been conducted to understand the links between stress, health and welfare in ornamental species. In aquaculture, many of the same stressors occur as those in the ornamental trade, including poor water quality, handling, transportation, confinement, poor social and physical environment and disease and in this sector directed research and some resulting interventions have resulted in improved welfare standards. This review considers the concept of welfare in fishes and evaluates reported rates of mortality in the ornamental trade. It assesses how the stress response can be quantified and used as a welfare indicator in fishes. It then analyses whether lessons from aquaculture can be usefully applied to the ornamental fish industry to improve welfare. Finally, this analysis is used to suggest how future research might be directed to help improve welfare in the ornamental trade. © 2017 The Fisheries Society of the British Isles.

Boldness and aggressiveness in early and late hatched three-spined sticklebacks Gasterosteus aculeatus.

PubMed

Ruiz-Gomez, M L; Huntingford, F A

2012-08-01

Levels of boldness and the degree of aggressiveness were compared in juvenile three-spined sticklebacks Gasterosteus aculeatus that had hatched early and late in the breeding season. The most striking result found in this study was that early hatched individuals were bolder when exploring a novel environment than were late-hatched individuals. No differences in levels of aggression between early and late hatchlings were found, but a relationship between boldness and aggressiveness was present regardless of hatching date. The implications of these findings are discussed in the light of research on individual variation in behaviour and the development of behavioural syndromes. © 2012 The Authors. Journal of Fish Biology © 2012 The Fisheries Society of the British Isles.

Unionid bivalves (Mollusca: Bivalvia: Unionidae) of Presque Isle Bay, Erie, Pennsylvania

USGS Publications Warehouse

Masteller, E.C.; Maleski, K.R.; Schloesser, D.W.

1993-01-01

The purpose of this study was to determine species composition and relative abundance of unionid bivalves (Mollusca: Bivalvia: Unionidae) in Presque Isle Bay, Erie, Pennsylvania 1990-1992. This information was compared with data from the only other extensive survey of unionids in the bay conducted in 1909-1911 (Ortmann 1919) to assess changes over the 80 years preceding the present study. A total of 1,540 individuals representing 18 species were collected in 1990-1992. Five relatively common species (between 7 and 42% of total individuals), six uncommon species (2 and 6%), and seven rare species (<1%) were found. The rare species were Anodontoides ferussacianus, Lasmigona costata, Ligumia recta, Ptychobranchus fasciolaris, Quadrula pustulosa pustulosa, Strophitus undaulatus, and Truncilla donaciformis. Five of the species found in Presque Isle Bay (Leptodea fragilis, Ligumia nasuta, Potamilus alatus, Quadrula quadrula, and Truncilla donaciformis) are listed as critically imperiled and one species (Truncilla truncata) as extirpated in the State of Pennsylvania by the Western Pennsylvania Conservancy. Comparisons between unionid populations in 1909-1911 and 1990-1992 indicate few substantial changes occurred during the past 80 years. A total of 22 species were found; 21 in 1909-1911 and 18 in 1990-1992. Seventeen species were found in both studies, an additional four in 1909-1911 and one in 1990-1992. The relative abundance of 11 of the 17 species found in both studies remained stable (i.e., common or uncommon) over the past 80 years. Only four species listed as uncommon in 1909-1911 were listed as rare in 1990-1992. However, the invasion of the zebra mussel (Dreissena polymorpha) is considered a threat to the continued existence of the entire Unionidae fauna in Presque Isle Bay, a unique habitat of the Great Lakes.

Insights into hydrologic and hydrochemical processes based on concentration-discharge and end-member mixing analyses in the mid-Merced River Basin, Sierra Nevada, California

NASA Astrophysics Data System (ADS)

Liu, Fengjing; Conklin, Martha H.; Shaw, Glenn D.

2017-01-01

Both concentration-discharge relation and end-member mixing analysis were explored to elucidate the connectivity of hydrologic and hydrochemical processes using chemical data collected during 2006-2008 at Happy Isles (468 km2), Pohono Bridge (833 km2), and Briceburg (1873 km2) in the snowmelt-fed mid-Merced River basin, augmented by chemical data collected by the USGS during 1990-2014 at Happy Isles. Concentration-discharge (C-Q) in streamflow was dominated by a well-defined power law relation, with the magnitude of exponent (0.02-0.6) and R2 values (p < 0.001) lower on rising than falling limbs. Concentrations of conservative solutes in streamflow resulted from mixing of two end-members at Happy Isles and Pohono Bridge and three at Briceburg, with relatively constant solute concentrations in end-members. The fractional contribution of groundwater was higher on rising than falling limbs at all basin scales. The relationship between the fractional contributions of subsurface flow and groundwater and streamflow (F-Q) followed the same relation as C-Q as a result of end-member mixing. The F-Q relation was used as a simple model to simulate subsurface flow and groundwater discharges to Happy Isles from 1990 to 2014 and was successfully validated by solute concentrations measured by the USGS. It was also demonstrated that the consistency of F-Q and C-Q relations is applicable to other catchments where end-members and the C-Q relationships are well defined, suggesting hydrologic and hydrochemical processes are strongly coupled and mutually predictable. Combining concentration-discharge and end-member mixing analyses could be used as a diagnostic tool to understand streamflow generation and hydrochemical controls in catchment hydrologic studies.

Seismic stratigraphy of barrier-island arc retreat paths in Mississippi River delta

DOE Office of Scientific and Technical Information (OSTI.GOV)

Penland, S.; Suter, J.R.

1983-09-01

The stratigraphic record preserved in the retreat path of Mississippi delta barrier-island arcs is controlled by erosional shoreface retreat processes, relative sea level rise, and sediment supply. More than 500 km (300 mi) of high resolution shallow seismic profiles correlated with vibracores from retreat paths fronting the Isles Dernieres and Chandeleur barrier-island arcs, show contrasting stratigraphic sequences preserved on the inner continental shelf (Mississippian delta). The Isles Dernieres barrier-island arc developed as a consequence of the Caillou Headland abandonment in the early Lafourche delta approximately 800 years B.P. On the lower shoreface, channels can be seen projecting seaward under themore » central part of the island arc; associated with it is a beach-ridge plain extending eastward. On the inner shelf, a sand sheet up to 60 cm (2 ft) thick marks the retreat path of the Isles Dernieres. The Chandeleur barrier-island arc was generated by abandonment of the St. Bernard delta complex 1,500 years ago. Scattered outcrops of shell reefs and lagoonal deposits occur on the lower shoreface. Beyond the shoreface, a 1 to 5 m (3 to 16 ft) thick sand sheet, caps tidal inlet scars up to 10 m (33 ft) thick, as well as the basal portions of migrating barrier-island sequences associated with earlier shoreline positions. Differences seen in the two stratigraphic sequences are a function of distributary size and depositional history of each barrier-island arc. The Isles Dernieres developed from a series of small sand-deficient distributaries in the Lafourche delta complex, whereas the Chandeleur Islands developed from large sand-rich distributaries of the St. Bernard delta complex.« less

Processes controlling the retreat of the Isles Dernieres, a Louisiana barrier-island chain

USGS Publications Warehouse

Dingler, John R.; Reiss, Thomas E.

1991-01-01

The Isles Dernieres is a low-lying, transgressive barrier-island chain situated about 150 km west of the modern Mississippi delta. Much of the Isles Dernieres consists of highly dissected salt-marsh muds that lie at or slightly above sea level and are covered by a veneer of sand along the shoreline facing the Gulf of Mexico. Maximum berm elevations are generally less than 1.5 m above mean sea level. Since the mid-1800s, the initial island has been fragmented into four islands, and the beach face has retreated landward at a rate of more than 10 m/yr. The dominant processes controlling degradation of the chain are cold fronts that pass through the area several times each year and occasional hurricanes. Beach surveys over a 2-year period on the Isles Dernieres document irreversible beach-face retreat in conjunction with multiple cold fronts and one major hurricane (Gilbert). Although both the hurricane and the cold fronts caused the island to erode, the erosional patterns of the two storm types differed from each other. During the two years, over 60 cold fronts collectively caused about 37 m of beach-face retreat, whereas Gilbert itself produced more than 40 m of retreat. A major difference between the two storm types was in the percentage of washover sand produced by each. Commonly, the cold fronts did not create enough of a storm surge to overtop the berm, so most of the material removed from the beach face must have moved offshore or alongshore. Gilbert, in contrast, inundated the study site, and essentially all the sand removed from the beach face moved to the backshore.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Montemayor, Eric J.; Didychuk, Allison L.; Liao, Honghong

U6 small nuclear RNA (snRNA) is a key component of the active site of the spliceosome, a large ribonucleoprotein complex that catalyzes the splicing of precursor messenger RNA. Prior to its incorporation into the spliceosome, U6 is bound by the protein Prp24, which facilitates unwinding of the U6 internal stem-loop (ISL) so that it can pair with U4 snRNA. A previously reported crystal structure of the `core' of the U6 small nuclear ribonucleoprotein (snRNP) contained an ISL-stabilized A62G mutant of U6 bound to all four RNA-recognition motif (RRM) domains of Prp24 [Montemayoret al.(2014),Nature Struct. Mol. Biol.21, 544–551]. The structure revealedmore » a novel topology containing interlocked rings of protein and RNA that was not predicted by prior biochemical and genetic data. Here, the crystal structure of the U6 snRNP core with a wild-type ISL is reported. This complex crystallized in a new space group, apparently owing in part to the presence of an intramolecular cross-link in RRM1 that was not observed in the previously reported U6-A62G structure. The structure exhibits the same protein–RNA interface and maintains the unique interlocked topology. However, the orientation of the wild-type ISL is altered relative to the A62G mutant structure, suggesting inherent structural dynamics that may facilitate its pairing with U4. Consistent with their similar architectures in the crystalline state, the wild-type and A62G variants of U6 exhibit similar Prp24-binding affinities and electrophoretic mobilities when analyzed by gel-shift assay.« less

Investigation on scalable high-power lasers with enhanced 'eye-safety' for future weapon systems

NASA Astrophysics Data System (ADS)

Bigotta, S.; Diener, K.; Eichhorn, M.; Galecki, L.; Geiss, L.; Ibach, T.; Scharf, H.; von Salisch, M.; Schöner, J.; Vincent, G.

2016-10-01

The possible use of lasers as weapons becomes more and more interesting for military forces. Besides the generation of high laser power and good beam quality, also safety considerations, e. g. concerning eye hazards, are of importance. The MELIAS (medium energy laser in the "eye-safe" spectral domain) project of ISL addresses these issues, and ISL has developed the most powerful solid-state laser in the "eye-safe" wavelength region up to now. "Eye safety" in this context means that light at a wavelength of > 1.4 μm does not penetrate the eye and thus will not be focused onto the retina. The basic principle of this technology is that a laser source needs to be scalable in power to far beyond 100 kW without a significant deterioration in beam quality. ISL has studied a very promising laser technology: the erbium heat-capacity laser. This type of laser is characterised by a compact design, a simple and robust technology and a scaling law which, in principle, allows the generation of laser power far beyond megawatts at small volumes. Previous investigations demonstrated the scalability of the SSHCL and up to 4.65 kW and 440 J in less than 800 ms have been obtained. Opticalto- optical efficiencies of over 41% and slope efficiencies of over 51% are obtained. The residual thermal gradients, due to non perfect pumping homogeneity, negatively affect the performance in terms of laser pulse energy, duration and beam quality. In the course of the next two years, ISL will be designing a 25 to 30 kW erbium heat-capacity laser.

Improving niche projections of plant species under climate change: Silene acaulis on the British Isles as a case study

NASA Astrophysics Data System (ADS)

Ferrarini, Alessandro; Alsafran, Mohammed H. S. A.; Dai, Junhu; Alatalo, Juha M.

2018-04-01

Empirical works to assist in choosing climatically relevant variables in the attempt to predict climate change impacts on plant species are limited. Further uncertainties arise in choice of an appropriate niche model. In this study we devised and tested a sharp methodological framework, based on stringent variable ranking and filtering and flexible model selection, to minimize uncertainty in both niche modelling and successive projection of plant species distributions. We used our approach to develop an accurate, parsimonious model of Silene acaulis (L.) presence/absence on the British Isles and to project its presence/absence under climate change. The approach suggests the importance of (a) defining a reduced set of climate variables, actually relevant to species presence/absence, from an extensive list of climate predictors, and (b) considering climate extremes instead of, or together with, climate averages in projections of plant species presence/absence under future climate scenarios. Our methodological approach reduced the number of relevant climate predictors by 95.23% (from 84 to only 4), while simultaneously achieving high cross-validated accuracy (97.84%) confirming enhanced model performance. Projections produced under different climate scenarios suggest that S. acaulis will likely face climate-driven fast decline in suitable areas on the British Isles, and that upward and northward shifts to occupy new climatically suitable areas are improbable in the future. Our results also imply that conservation measures for S. acaulis based upon assisted colonization are unlikely to succeed on the British Isles due to the absence of climatically suitable habitat, so different conservation actions (seed banks and/or botanical gardens) are needed.

Tidal flow dynamics and background fluorescence of the Atlantic Intracoastal Waterway in the vicinity of Sullivan’s Island and the Isle of Palms, South Carolina, 2011-12

USGS Publications Warehouse

Conrads, Paul; Journey, Celeste A.; Clark, Jimmy M.; Levesque, Victor A.

2013-01-01

To effectively plan site-specific studies to understand the connection between wastewater effluent and shellfish beds, data are needed concerning flow dynamics and background fluorescence in the Atlantic Intracoastal Waterway near the effluent outfalls on Sullivan’s Island and the Isle of Palms. Tidal flows were computed by the U.S. Geological Survey for three stations and longitudinal water-quality profiles were collected at high and low tide. Flows for the three U.S. Geological Survey stations, the Atlantic Intracoastal Waterway by the Isle of Palms Marina, the Atlantic Intracoastal Waterway by the Ben M. Sawyer Memorial Bridge at Sullivan’s Island, and Breach Inlet, were computed for the 53-day period from December 4, 2011, to January 26, 2012. The largest flows occurred at Breach Inlet and ranged from -58,600 cubic feet per second (ft3/s) toward the Atlantic Intracoastal Waterway to 63,300 ft3/s toward the Atlantic Ocean. Of the two stations on the Atlantic Intracoastal Waterway, the Sullivan’s Island station had the larger flows and ranged from -6,360 ft3/s to the southwest (toward Charleston Harbor) to 8,930 ft3/s to the northeast. Computed tidal flow at the Isle of Palms station ranged from -3,460 ft3/s toward the southwest to 6,410 ft3/s toward the northeast. The synoptic water-quality study showed that the stations were well mixed vertically and horizontally. All fluorescence measurements (recorded as rhodamine concentration) were below the accuracy of the sensor and the background fluorescence would not likely interfere with a dye-tracer study.

First description of the neuro-anatomy of a larval coral reef fish Amphiprion ocellaris.

PubMed

Jacob, H; Metian, M; Brooker, R M; Duran, E; Nakamura, N; Roux, N; Masanet, P; Soulat, O; Lecchini, D

2016-09-01

The present study described the neuro-anatomy of a larval coral reef fish Amphiprion ocellaris and hypothesized that morphological changes during the transition from the oceanic environment to a reef environment (i.e. recruitment) have the potential to be driven by changes to environmental conditions and associated changes to cognitive requirements. Quantitative comparisons were made of the relative development of three specific brain areas (telencephalon, mesencephalon and cerebellum) between 6 days post-hatch (dph) larvae (oceanic phase) and 11 dph (at reef recruitment). The results showed that 6 dph larvae had at least two larger structures (telencephalon and mesencephalon) than 11 dph larvae, while the size of cerebellum remained identical. These results suggest that the structure and organization of the brain may reflect the cognitive demands at every stage of development. This study initiates analysis of the relationship between behavioural ecology and neuroscience in coral reef fishes. © 2016 The Fisheries Society of the British Isles.

Metacognitive components in smart learning environment

NASA Astrophysics Data System (ADS)

Sumadyo, M.; Santoso, H. B.; Sensuse, D. I.

2018-03-01

Metacognitive ability in digital-based learning process helps students in achieving learning goals. So that digital-based learning environment should make the metacognitive component as a facility that must be equipped. Smart Learning Environment is the concept of a learning environment that certainly has more advanced components than just a digital learning environment. This study examines the metacognitive component of the smart learning environment to support the learning process. A review of the metacognitive literature was conducted to examine the components involved in metacognitive learning strategies. Review is also conducted on the results of study smart learning environment, ranging from design to context in building smart learning. Metacognitive learning strategies certainly require the support of adaptable, responsive and personalize learning environments in accordance with the principles of smart learning. The current study proposed the role of metacognitive component in smart learning environment, which is useful as the basis of research in building environment in smart learning.

Wireless acoustic modules for real-time data fusion using asynchronous sniper localization algorithms

NASA Astrophysics Data System (ADS)

Hengy, S.; De Mezzo, S.; Duffner, P.; Naz, P.

2012-11-01

The presence of snipers in modern conflicts leads to high insecurity for the soldiers. In order to improve the soldier's protection against this threat, the French German Research Institute of Saint-Louis (ISL) has been conducting studies in the domain of acoustic localization of shots. Mobile antennas mounted on the soldier's helmet were initially used for real-time detection, classification and localization of sniper shots. It showed good performances in land scenarios, but also in urban scenarios if the array was in the shot corridor, meaning that the microphones first detect the direct wave and then the reflections of the Mach and muzzle waves (15% distance estimation error compared to the actual shooter array distance). Fusing data sent by multiple sensor nodes distributed on the field showed some of the limitations of the technologies that have been implemented in ISL's demonstrators. Among others, the determination of the arrays' orientation was not accurate enough, thereby degrading the performance of data fusion. Some new solutions have been developed in the past year in order to obtain better performance for data fusion. Asynchronous localization algorithms have been developed and post-processed on data measured in both free-field and urban environments with acoustic modules on the line of sight of the shooter. These results are presented in the first part of the paper. The impact of GPS position estimation error is also discussed in the article in order to evaluate the possible use of those algorithms for real-time processing using mobile acoustic nodes. In the frame of ISL's transverse project IMOTEP (IMprovement Of optical and acoustical TEchnologies for the Protection), some demonstrators are developed that will allow real-time asynchronous localization of sniper shots. An embedded detection and classification algorithm is implemented on wireless acoustic modules that send the relevant information to a central PC. Data fusion is then processed and the estimated position of the shooter is sent back to the users. A SWIR active imaging system is used for localization refinement. A built-in DSP is related to the detection/classification tasks for each acoustic module. A GPS module is used for time difference of arrival and module's position estimation. Wireless communication is supported using ZigBee technology. These acoustic modules are described in the article and first results of real-time asynchronous sniper localization using those modules are discussed.

Cleveland Harbor, Ohio Draft Reformulation Phase I General Design Memorandum and Draft Supplement to the Final Environmental Impact Statement. Revision.

DTIC Science & Technology

1984-02-01

OH :0 0 :0 : 0 : 0 :0 : 0 : 0 :0 :0.3: - Marquette, MI :0.1: 0 :0 :0 :0 :0 :0 :0 :0 0 Presque Isle , MI : 1.4 : 1.3 : 1.4 : 1.5 : 1.0 : 0.9 : 0.4...680.0 Self Unloader 1973 MESABI MINER 1,004.0 Self Unloader 1973 PRESQUE ISLE 1,000.0 Self Unloader 1973 ROESCH, WILLIAM R. 630.0 Self Unloader 1973...Island Light Station " West Sister Island Light Marquette Harbor Lighthouse Pointe Betsie Light Station Pennsylvania Port Sanilac Light Station Presque

Temporal genetic variation of the red fox, Vulpes vulpes, across western Europe and the British Isles

NASA Astrophysics Data System (ADS)

Edwards, Ceiridwen J.; Soulsbury, Carl D.; Statham, Mark J.; Ho, Simon Y. W.; Wall, Dave; Dolf, Gaudenz; Iossa, Graziella; Baker, Phillip J.; Harris, Stephen; Sacks, Benjamin N.; Bradley, Daniel G.

2012-12-01

Quaternary climatic fluctuations have had profound effects on the phylogeographic structure of many species. Classically, species were thought to have become isolated in peninsular refugia, but there is limited evidence that large, non-polar species survived outside traditional refugial areas. We examined the phylogeographic structure of the red fox (Vulpes vulpes), a species that shows high ecological adaptability in the western Palaearctic region. We compared mitochondrial DNA sequences (cytochrome b and control region) from 399 modern and 31 ancient individuals from across Europe. Our objective was to test whether red foxes colonised the British Isles from mainland Europe in the late Pleistocene, or whether there is evidence that they persisted in the region through the Last Glacial Maximum. We found red foxes to show a high degree of phylogeographic structuring across Europe and, consistent with palaeontological and ancient DNA evidence, confirmed via phylogenetic indicators that red foxes were persistent in areas outside peninsular refugia during the last ice age. Bayesian analyses and tests of neutrality indicated population expansion. We conclude that there is evidence that red foxes from the British Isles derived from central European populations that became isolated after the closure of the landbridge with Europe.

Temporal genetic variation of the red fox, Vulpes vulpes, across western Europe and the British Isles.

PubMed

Edwards, Ceiridwen J; Soulsbury, Carl D; Statham, Mark J; Ho, Simon Y W; Wall, Dave; Dolf, Gaudenz; Iossa, Graziella; Baker, Phillip J; Harris, Stephen; Sacks, Benjamin N; Bradley, Daniel G

2012-12-04

Quaternary climatic fluctuations have had profound effects on the phylogeographic structure of many species. Classically, species were thought to have become isolated in peninsular refugia, but there is limited evidence that large, non-polar species survived outside traditional refugial areas. We examined the phylogeographic structure of the red fox ( Vulpes vulpes ), a species that shows high ecological adaptability in the western Palaearctic region. We compared mitochondrial DNA sequences (cytochrome b and control region) from 399 modern and 31 ancient individuals from across Europe. Our objective was to test whether red foxes colonised the British Isles from mainland Europe in the late Pleistocene, or whether there is evidence that they persisted in the region through the Last Glacial Maximum. We found red foxes to show a high degree of phylogeographic structuring across Europe and, consistent with palaeontological and ancient DNA evidence, confirmed via phylogenetic indicators that red foxes were persistent in areas outside peninsular refugia during the last ice age. Bayesian analyses and tests of neutrality indicated population expansion. We conclude that there is evidence that red foxes from the British Isles derived from central European populations that became isolated after the closure of the landbridge with Europe.

Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages

PubMed Central

Laugwitz, Karl-Ludwig; Moretti, Alessandra; Lam, Jason; Gruber, Peter; Chen, Yinhong; Woodard, Sarah; Lin, Li-Zhu; Cai, Chen-Leng; Lu, Min Min; Reth, Michael; Platoshyn, Oleksandr; Yuan, Jason X.-J.; Evans, Sylvia; Chien, Kenneth R.

2017-01-01

The purification, renewal and differentiation of native cardiac progenitors would form a mechanistic underpinning for unravelling steps for cardiac cell lineage formation, and their links to forms of congenital and adult cardiac diseases1–3. Until now there has been little evidence for native cardiac precursor cells in the postnatal heart4. Herein, we report the identification of isl1+ cardiac progenitors in postnatal rat, mouse and human myocardium. A cardiac mesenchymal feeder layer allows renewal of the isolated progenitor cells with maintenance of their capability to adopt a fully differentiated cardiomyocyte phenotype. Tamoxifen-inducible Cre/lox technology enables selective marking of this progenitor cell population including its progeny, at a defined time, and purification to relative homogeneity. Co-culture studies with neonatal myocytes indicate that isl1+ cells represent authentic, endogenous cardiac progenitors (cardioblasts) that display highly efficient conversion to a mature cardiac phenotype with stable expression of myocytic markers (25%) in the absence of cell fusion, intact Ca2+-cycling, and the generation of action potentials. The discovery of native cardioblasts represents a genetically based system to identify steps in cardiac cell lineage formation and maturation in development and disease. PMID:15703750

The O and H stable isotope composition of freshwaters in the British Isles. 2. Surface waters and groundwater

NASA Astrophysics Data System (ADS)

Darling, W. G.; Bath, A. H.; Talbot, J. C.

The utility of stable isotopes as tracers of the water molecule has a long pedigree. The study reported here is part of an attempt to establish a comprehensive isotopic "baseline" for the British Isles as background data for a range of applications. Part 1 of this study (Darling and Talbot, 2003) considered the isotopic composition of rainfall in Britain and Ireland. The present paper is concerned with the composition of surface waters and groundwater. In isotopic terms, surface waters (other than some upland streams) are poorly characterised in the British Isles; their potential variability has yet to be widely used as an aid in hydrological research. In what may be the first study of a major British river, a monthly isotopic record of the upper River Thames during 1998 was obtained. This shows high damping of the isotopic variation compared to that in rainfall over most of the year, though significant fluctuations were seen for the autumn months. Smaller rivers such as the Stour and Darent show a more subdued response to the balance between runoff and baseflow. The relationship between the isotopic composition of rainfall and groundwater is also considered. From a limited database, it appears that whereas Chalk groundwater is a representative mixture of weighted average annual rainfall, for Triassic sandstone groundwater there is a seasonal selection of rainfall biased towards isotopically-depleted winter recharge. This may be primarily the result of physical differences between the infiltration characteristics of rock types, though other factors (vegetation, glacial history) could be involved. In the main, however, groundwaters appear to be representative of bulk rainfall within an error band of 0.5‰ δ18O. Contour maps of the δ18O and δ2H content of recent groundwaters in the British Isles show a fundamental SW-NE depletion effect modified by topography. The range of measured values, while much smaller than those for rainfall, still covers some ‰ for δ18O and 30‰ for δ2H. Over lowland areas the "altitude effect" is of little significance, but in upland areas is consistent with a range of -0.2 to -0.3‰ per 100 m increase in altitude. Groundwaters dating from the late Pleistocene are usually modified in δ18O and δ2H owing to the effects of climate change on the isotopic composition of rainfall and thus of recharge. Contour maps of isotopic variability prior to 10 ka BP, based on the relatively limited information available from the British Isles, allow a first comparison between groundwaters now and at the end of the last Ice Age. The position of the British Isles in the context of the stable isotope systematics of NW Europe is reviewed briefly.

Decompression Sickness During Simulated Low Pressure Exposure is Increased with Mild Ambulation Exercise

NASA Technical Reports Server (NTRS)

Pollock, N. W.; Natoli, M. J.; Martina, S. D.; Conkin, J.; Wessel, J. H., III; Gernhardt, M. L.

2016-01-01

Musculoskeletal activity accelerates inert gas elimination during oxygen breathing prior to decompression (prebreathe), but may also promote bubble formation (nucleation) and increase the risk of decompression sickness (DCS). The timing, pattern and intensity of musculoskeletal activity are likely critical to the net effect. The NASA Prebreathe Reduction Program (PRP) combined oxygen prebreathe and exercise preceding a 4.3 psia exposure in non-ambulatory subjects (a microgravity analog) to produce two protocols now used by astronauts preparing for extravehicular activity - one employing cycling and non-cycling exercise (CEVIS: 'cycle ergometer vibration isolation system') and one relying on non-cycling exercise only (ISLE: 'in-suit light exercise'). Current efforts investigate whether light exercise normal to 1 G environments increases the risk of DCS over microgravity simulation.

Habitat-related specialization of lateral-line system morphology in a habitat-generalist and a habitat-specialist New Zealand eleotrid.

PubMed

Vanderpham, J P; Nakagawa, S; Senior, A M; Closs, G P

2016-04-01

An investigation of intraspecific habitat-related patterns of variation in oculoscapular lateral-line superficial neuromasts (SN) identified a decrease in the ratio of total SNs to pores, and a trend towards decreased asymmetry in SNs in the habitat-generalist common bully Gobiomorphus cotidianus from fluvial habitats compared to lacustrine habitats, suggesting habitat-related phenotypic variability. A greater ratio of pores to SNs, as well as less variation in the total number and asymmetry of SNs observed in the fluvial habitat-specialist redfin bully Gobiomorphus huttoni may provide further evidence of variations in the oculoscapular lateral-line morphology of fluvial habitat G. cotidianus individuals serving as adaptations to more turbulent environments. © 2016 The Fisheries Society of the British Isles.

Effects of congruence between preferred and perceived learning environments in nursing education in Taiwan: a cross-sectional study.

PubMed

Yeh, Ting-Kuang; Huang, Hsiu-Mei; Chan, Wing P; Chang, Chun-Yen

2016-05-20

To investigate the effects of congruence between preferred and perceived learning environments on learning outcomes of nursing students. A nursing course at a university in central Taiwan. 124 Taiwanese nursing students enrolled in a 13-week problem-based Fundamental Nursing curriculum. Students' preferred learning environment, perceptions about the learning environment and learning outcomes (knowledge, self-efficacy and attitudes) were assessed. On the basis of test scores measuring their preferred and perceived learning environments, students were assigned to one of two groups: a 'preferred environment aligned with perceived learning environment' group and a 'preferred environment discordant with perceived learning environment' group. Learning outcomes were analysed by group. Most participants preferred learning in a classroom environment that combined problem-based and lecture-based instruction. However, a mismatch of problem-based instruction with students' perceptions occurred. Learning outcomes were significantly better when students' perceptions of their instructional activities were congruent with their preferred learning environment. As problem-based learning becomes a focus of educational reform in nursing, teachers need to be aware of students' preferences and perceptions of the learning environment. Teachers may also need to improve the match between an individual student's perception and a teacher's intention in the learning environment, and between the student's preferred and actual perceptions of the learning environment. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

iCollections methodology: workflow, results and lessons learned

PubMed Central

Penn, Malcolm; Sadka, Mike; Hine, Adrian; Brooks, Stephen; Siebert, Darrell J.; Sleep, Chris; Cafferty, Steve; Cane, Elisa; Martin, Geoff; Toloni, Flavia; Wing, Peter; Chainey, John; Duffell, Liz; Huxley, Rob; Ledger, Sophie; McLaughlin, Caitlin; Mazzetta, Gerardo; Perera, Jasmin; Crowther, Robyn; Douglas, Lyndsey; Durant, Joanna; Scialabba, Elisabetta; Honey, Martin; Huertas, Blanca; Howard, Theresa; Carter, Victoria; Albuquerque, Sara; Paterson, Gordon; Kitching, Ian J.

2017-01-01

Abstract The Natural History Museum, London (NHMUK) has embarked on an ambitious programme to digitise its collections. The first phase of this programme was to undertake a series of pilot projects to develop the workflows and infrastructure needed to support mass digitisation of very large scientific collections. This paper presents the results of one of the pilot projects – iCollections. This project digitised all the lepidopteran specimens usually considered as butterflies, 181,545 specimens representing 89 species from the British Isles and Ireland. The data digitised includes, species name, georeferenced location, collector and collection date - the what, where, who and when of specimen data. In addition, a digital image of each specimen was taken. A previous paper explained the way the data were obtained and the background to the collections that made up the project. The present paper describes the technical, logistical, and economic aspects of managing the project. PMID:29104442

iCollections methodology: workflow, results and lessons learned

PubMed Central

Penn, Malcolm; Sadka, Mike; Hine, Adrian; Brooks, Stephen; Siebert, Darrell J.; Sleep, Chris; Cafferty, Steve; Cane, Elisa; Martin, Geoff; Toloni, Flavia; Wing, Peter; Chainey, John; Duffell, Liz; Huxley, Rob; Ledger, Sophie; McLaughlin, Caitlin; Mazzetta, Gerardo; Perera, Jasmin; Crowther, Robyn; Douglas, Lyndsey; Durant, Joanna; Honey, Martin; Huertas, Blanca; Howard, Theresa; Carter, Victoria; Albuquerque, Sara; Paterson, Gordon; Kitching, Ian J.

2017-01-01

Abstract The Natural History Museum, London (NHMUK) has embarked on an ambitious programme to digitise its collections. The first phase of this programme was to undertake a series of pilot projects to develop the workflows and infrastructure needed to support mass digitisation of very large scientific collections. This paper presents the results of one of the pilot projects – iCollections. This project digitised all the lepidopteran specimens usually considered as butterflies, 181,545 specimens representing 89 species from the British Isles and Ireland. The data digitised includes, species name, georeferenced location, collector and collection date - the what, where, who and when of specimen data. In addition, a digital image of each specimen was taken. A previous paper explained the way the data were obtained and the background to the collections that made up the project. The present paper describes the technical, logistical, and economic aspects of managing the project. PMID:29104435

iCollections methodology: workflow, results and lessons learned.

PubMed

Blagoderov, Vladimir; Penn, Malcolm; Sadka, Mike; Hine, Adrian; Brooks, Stephen; Siebert, Darrell J; Sleep, Chris; Cafferty, Steve; Cane, Elisa; Martin, Geoff; Toloni, Flavia; Wing, Peter; Chainey, John; Duffell, Liz; Huxley, Rob; Ledger, Sophie; McLaughlin, Caitlin; Mazzetta, Gerardo; Perera, Jasmin; Crowther, Robyn; Douglas, Lyndsey; Durant, Joanna; Honey, Martin; Huertas, Blanca; Howard, Theresa; Carter, Victoria; Albuquerque, Sara; Paterson, Gordon; Kitching, Ian J

2017-01-01

The Natural History Museum, London (NHMUK) has embarked on an ambitious programme to digitise its collections. The first phase of this programme was to undertake a series of pilot projects to develop the workflows and infrastructure needed to support mass digitisation of very large scientific collections. This paper presents the results of one of the pilot projects - iCollections. This project digitised all the lepidopteran specimens usually considered as butterflies, 181,545 specimens representing 89 species from the British Isles and Ireland. The data digitised includes, species name, georeferenced location, collector and collection date - the what, where, who and when of specimen data. In addition, a digital image of each specimen was taken. A previous paper explained the way the data were obtained and the background to the collections that made up the project. The present paper describes the technical, logistical, and economic aspects of managing the project.

Distinctive Feature Extraction for Indian Sign Language (ISL) Gesture using Scale Invariant Feature Transform (SIFT)

NASA Astrophysics Data System (ADS)

Patil, Sandeep Baburao; Sinha, G. R.

2017-02-01

India, having less awareness towards the deaf and dumb peoples leads to increase the communication gap between deaf and hard hearing community. Sign language is commonly developed for deaf and hard hearing peoples to convey their message by generating the different sign pattern. The scale invariant feature transform was introduced by David Lowe to perform reliable matching between different images of the same object. This paper implements the various phases of scale invariant feature transform to extract the distinctive features from Indian sign language gestures. The experimental result shows the time constraint for each phase and the number of features extracted for 26 ISL gestures.

Population structure and abundance of arsenite-oxidizing bacteria along an arsenic pollution gradient in waters of the upper isle River Basin, France.

PubMed

Quéméneur, Marianne; Cébron, Aurélie; Billard, Patrick; Battaglia-Brunet, Fabienne; Garrido, Francis; Leyval, Corinne; Joulian, Catherine

2010-07-01

Denaturing gradient gel electrophoresis (DGGE) and quantitative real-time PCR (qPCR) were successfully developed to monitor functional aoxB genes as markers of aerobic arsenite oxidizers. DGGE profiles showed a shift in the structure of the aoxB-carrying bacterial population, composed of members of the Alpha-, Beta- and Gammaproteobacteria, depending on arsenic (As) and E(h) levels in Upper Isle River Basin waters. The highest aoxB gene densities were found in the most As-polluted oxic surface waters but without any significant correlation with environmental factors. Arsenite oxidizers seem to play a key role in As mobility in As-impacted waters.

Effects of congruence between preferred and perceived learning environments in nursing education in Taiwan: a cross-sectional study

PubMed Central

Yeh, Ting-Kuang; Huang, Hsiu-Mei; Chan, Wing P; Chang, Chun-Yen

2016-01-01

Objective To investigate the effects of congruence between preferred and perceived learning environments on learning outcomes of nursing students. Setting A nursing course at a university in central Taiwan. Participants 124 Taiwanese nursing students enrolled in a 13-week problem-based Fundamental Nursing curriculum. Design and methods Students' preferred learning environment, perceptions about the learning environment and learning outcomes (knowledge, self-efficacy and attitudes) were assessed. On the basis of test scores measuring their preferred and perceived learning environments, students were assigned to one of two groups: a ‘preferred environment aligned with perceived learning environment’ group and a ‘preferred environment discordant with perceived learning environment’ group. Learning outcomes were analysed by group. Outcome measures Most participants preferred learning in a classroom environment that combined problem-based and lecture-based instruction. However, a mismatch of problem-based instruction with students' perceptions occurred. Learning outcomes were significantly better when students' perceptions of their instructional activities were congruent with their preferred learning environment. Conclusions As problem-based learning becomes a focus of educational reform in nursing, teachers need to be aware of students' preferences and perceptions of the learning environment. Teachers may also need to improve the match between an individual student's perception and a teacher's intention in the learning environment, and between the student's preferred and actual perceptions of the learning environment. PMID:27207620

Science Learning Outcomes in Alignment with Learning Environment Preferences

NASA Astrophysics Data System (ADS)

Chang, Chun-Yen; Hsiao, Chien-Hua; Chang, Yueh-Hsia

2011-04-01

This study investigated students' learning environment preferences and compared the relative effectiveness of instructional approaches on students' learning outcomes in achievement and attitude among 10th grade earth science classes in Taiwan. Data collection instruments include the Earth Science Classroom Learning Environment Inventory and Earth Science Learning Outcomes Inventory. The results showed that most students preferred learning in a classroom environment where student-centered and teacher-centered instructional approaches coexisted over a teacher-centered learning environment. A multivariate analysis of covariance also revealed that the STBIM students' cognitive achievement and attitude toward earth science were enhanced when the learning environment was congruent with their learning environment preference.

High speed micro scanner for 3D in-volume laser micro processing

NASA Astrophysics Data System (ADS)

Schaefer, D.; Gottmann, J.; Hermans, M.; Ortmann, J.; Kelbassa, I.

2013-03-01

Using an in-house developed micro scanner three-dimensional micro components and micro fluidic devices in fused silica are realized using the ISLE process (in-volume selective laser-induced etching). With the micro scanner system the potential of high average power femtosecond lasers (P > 100 W) is exploited by the fabrication of components with micrometer precision at scan speeds of several meters per second. A commercially available galvanometer scanner is combined with an acousto-optical and/or electro-optical beam deflector and translation stages. For focusing laser radiation high numerical aperture microscope objectives (NA > 0.3) are used generating a focal volume of a few cubic micrometers. After laser exposure the materials are chemically wet etched in aqueous solution. The laser-exposed material is etched whereas the unexposed material remains nearly unchanged. Using the described technique called ISLE the fabrication of three-dimensional micro components, micro holes, cuts and channels is possible with high average power femtosecond lasers resulting in a reduced processing time for exposure. By developing the high speed micro scanner up-scaling of the ISLE process is demonstrated. The fabricated components made out of glass can be applied in various markets like biological and medical diagnostics as well as in micro mechanics.

Of mice and (Viking?) men: phylogeography of British and Irish house mice.

PubMed

Searle, Jeremy B; Jones, Catherine S; Gündüz, Islam; Scascitelli, Moira; Jones, Eleanor P; Herman, Jeremy S; Rambau, R Victor; Noble, Leslie R; Berry, R J; Giménez, Mabel D; Jóhannesdóttir, Fríoa

2009-01-22

The west European subspecies of house mouse (Mus musculus domesticus) has gained much of its current widespread distribution through commensalism with humans. This means that the phylogeography of M. m. domesticus should reflect patterns of human movements. We studied restriction fragment length polymorphism (RFLP) and DNA sequence variations in mouse mitochondrial (mt) DNA throughout the British Isles (328 mice from 105 localities, including previously published data). There is a major mtDNA lineage revealed by both RFLP and sequence analyses, which is restricted to the northern and western peripheries of the British Isles, and also occurs in Norway. This distribution of the 'Orkney' lineage fits well with the sphere of influence of the Norwegian Vikings and was probably generated through inadvertent transport by them. To form viable populations, house mice would have required large human settlements such as the Norwegian Vikings founded. The other parts of the British Isles (essentially most of mainland Britain) are characterized by house mice with different mtDNA sequences, some of which are also found in Germany, and which probably reflect both Iron Age movements of people and mice and earlier development of large human settlements. MtDNA studies on house mice have the potential to reveal novel aspects of human history.

Of mice and (Viking?) men: phylogeography of British and Irish house mice

PubMed Central

Searle, Jeremy B.; Jones, Catherine S.; Gündüz, İslam; Scascitelli, Moira; Jones, Eleanor P.; Herman, Jeremy S.; Rambau, R. Victor; Noble, Leslie R.; Berry, R.J.; Giménez, Mabel D.; Jóhannesdóttir, Fríða

2008-01-01

The west European subspecies of house mouse (Mus musculus domesticus) has gained much of its current widespread distribution through commensalism with humans. This means that the phylogeography of M. m. domesticus should reflect patterns of human movements. We studied restriction fragment length polymorphism (RFLP) and DNA sequence variations in mouse mitochondrial (mt) DNA throughout the British Isles (328 mice from 105 localities, including previously published data). There is a major mtDNA lineage revealed by both RFLP and sequence analyses, which is restricted to the northern and western peripheries of the British Isles, and also occurs in Norway. This distribution of the ‘Orkney’ lineage fits well with the sphere of influence of the Norwegian Vikings and was probably generated through inadvertent transport by them. To form viable populations, house mice would have required large human settlements such as the Norwegian Vikings founded. The other parts of the British Isles (essentially most of mainland Britain) are characterized by house mice with different mtDNA sequences, some of which are also found in Germany, and which probably reflect both Iron Age movements of people and mice and earlier development of large human settlements. MtDNA studies on house mice have the potential to reveal novel aspects of human history. PMID:18826939

Ischemia-reperfusion injury and pregnancy initiate time-dependent and robust signs of up-regulation of cardiac progenitor cells.

PubMed

Genead, Rami; Fischer, Helene; Hussain, Alamdar; Jaksch, Marie; Andersson, Agneta B; Ljung, Karin; Bulatovic, Ivana; Franco-Cereceda, Anders; Elsheikh, Elzafir; Corbascio, Matthias; Smith, C I Edvard; Sylvén, Christer; Grinnemo, Karl-Henrik

2012-01-01

To explore how cardiac regeneration and cell turnover adapts to disease, different forms of stress were studied for their effects on the cardiac progenitor cell markers c-Kit and Isl1, the early cardiomyocyte marker Nkx2.5, and mast cells. Adult female rats were examined during pregnancy, after myocardial infarction and ischemia-reperfusion injury with/out insulin like growth factor-1(IGF-1) and hepatocyte growth factor (HGF). Different cardiac sub-domains were analyzed at one and two weeks post-intervention, both at the mRNA and protein levels. While pregnancy and myocardial infarction up-regulated Nkx2.5 and c-Kit (adjusted for mast cell activation), ischemia-reperfusion injury induced the strongest up-regulation which occurred globally throughout the entire heart and not just around the site of injury. This response seems to be partly mediated by increased endogenous production of IGF-1 and HGF. Contrary to c-Kit, Isl1 was not up-regulated by pregnancy or myocardial infarction while ischemia-reperfusion injury induced not a global but a focal up-regulation in the outflow tract and also in the peri-ischemic region, correlating with the up-regulation of endogenous IGF-1. The addition of IGF-1 and HGF did boost the endogenous expression of IGF and HGF correlating to focal up-regulation of Isl1. c-Kit expression was not further influenced by the exogenous growth factors. This indicates that there is a spatial mismatch between on one hand c-Kit and Nkx2.5 expression and on the other hand Isl1 expression. In conclusion, ischemia-reperfusion injury was the strongest stimulus with both global and focal cardiomyocyte progenitor cell marker up-regulations, correlating to the endogenous up-regulation of the growth factors IGF-1 and HGF. Also pregnancy induced a general up-regulation of c-Kit and early Nkx2.5+ cardiomyocytes throughout the heart. Utilization of these pathways could provide new strategies for the treatment of cardiac disease.

Morphologic and biomechanical comparison of spinous processes and ligaments from scoliotic and kyphotic patients.

PubMed

Beaubien, Brian P; Freeman, Andrew L; Buttermann, Glenn R

2016-01-25

The spinous processes and supraspinous and interspinous ligaments (SSL and ISL, respectively) limit flexion and may relate to spinal curvature. Spinous process angles and mechanical properties of explanted human thoracic posterior SSL/ISL complexes were compared for scoliosis (n=14) vs. kyphosis (n=8) patients. The median thoracic coronal Cobb angle for scoliosis patients was 48°, and sagittal angles for kyphosis patients was 78°. Spinous processes were gripped and four strain steps of 4% were applied and held. Percent relaxation was calculated over each step, equilibrium load data were fit to an exponential equation, and a Kelvin model was fit to the load from all four curves. Failure testing was also performed. Median ligament complex dimensions from scoliosis and kyphosis patients were, respectively: ISL width=16.5mm and 16.0mm; SSL width=4.3mm and 3.8mm; ISL+SSL area=17.2mm and 25.7mm; these differences were not significant. Significant differences did exist in terms of spinous process angle vs. spine axis (47° for scoliosis and 32° for kyphosis) and SSL thickness (2.1mm for scoliosis and 3.0mm for kyphosis). Fourth-step median relaxation was 42% for scoliosis and 49% for kyphosis. Median linear region stiffness was 42N/mm for scoliosis and 51N/mm for kyphosis. Median failure load was 191N for scoliotic and 175N for kyphotic ligaments. Differences in loading, relaxation, viscoelastic and failure parameters were not statistically significant, except for a trend for greater initial rate of relaxation (T1) for scoliosis ligaments. However, we found significant morphological differences related to the spinous processes, which suggests a need for future biomechanical studies related to the musculoskeletal aspects of spinal alignment and posture. Copyright © 2015 Elsevier Ltd. All rights reserved.

Differentiation-inducing and anti-proliferative activities of isoliquiritigenin and all-trans-retinoic acid on B16F0 melanoma cells: Mechanisms profiling by RNA-seq.

PubMed

Chen, Xiaoyu; Yang, Ming; Hao, Wenjin; Han, Jichun; Ma, Jun; Wang, Caixia; Sun, Shiguo; Zheng, Qiusheng

2016-10-30

Melanoma is a cancer that arises from melanocytes, specialized pigmented cells that are found predominantly in the skin. The incidence of malignant melanoma has significantly increased over the last decade. With the development of therapy, the survival rate of some kind of cancer has been improved greatly. But the treatment of melanoma remains unsatisfactory. Much of melanoma's resistance to traditional chemotherapy is believed to arise intrinsically, by virtue of potent growth and cell survival-promoting genetic alteration. Therefore, significant attention has recently been focused on differentiation therapy, as well as differentiation inducer compounds. In previous study, we found isoliquiritigenin (ISL), a natural product extracted from licorice, could induce B16F0 melanoma cell differentiation. Here we investigated the transcriptional response of melanoma differentiation process induced by ISL and all-trans-retinoic acid (RA). Results showed that 390 genes involves in 201 biochemical pathways were differentially expressed in ISL treatment and 304 genes in 193 pathways in RA treatment. Differential expressed genes (DGEs, fold-change (FC)≥10) with the function of anti-proliferative and differentiation inducing indicated a loss of grade malignancy characteristic. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis indicated glutathione metabolism, glycolysis/gluconeogenesis and pentose phosphate pathway were the top three relative pathway perturbed by ISL, and mitogen-activated protein kinase (MAPK) signaling pathway was the most important pathway in RA treatment. In the analysis of hierarchical clustering of DEGs, we discovered 72 DEGs involved in the process of drug action. We thought Cited1, Tgm2, Xaf1, Cd59a, Fbxo2, Adh7 may have critical role in the differentiation of melanoma. The evidence displayed herein confirms the critical role of reactive oxygen species (ROS) in melanoma pathobiology and provides evidence for future targets in the development of next-generation biomarkers and therapeutics. Copyright © 2016 Elsevier B.V. All rights reserved.

Methylation of HOXA9 and ISL1 Predicts Patient Outcome in High-Grade Non-Invasive Bladder Cancer

PubMed Central

Kitchen, Mark O.; Bryan, Richard T.; Haworth, Kim E.; Emes, Richard D.; Luscombe, Christopher; Gommersall, Lyndon; Cheng, K. K.; Zeegers, Maurice P.; James, Nicholas D.; Devall, Adam J.; Fryer, Anthony A.; Farrell, William E.

2015-01-01

Introduction Inappropriate DNA methylation is frequently associated with human tumour development, and in specific cases, is associated with clinical outcomes. Previous reports of DNA methylation in low/intermediate grade non-muscle invasive bladder cancer (NMIBC) have suggested that specific patterns of DNA methylation may have a role as diagnostic or prognostic biomarkers. In view of the aggressive and clinically unpredictable nature of high-grade (HG) NMIBC, and the current shortage of the preferred treatment option (Bacillus:Calmette-Guerin), novel methylation analyses may similarly reveal biomarkers of disease outcome that could risk-stratify patients and guide clinical management at initial diagnosis. Methods Promoter-associated CpG island methylation was determined in primary tumour tissue of 36 initial presentation high-grade NMIBCs, 12 low/intermediate-grade NMIBCs and 3 normal bladder controls. The genes HOXA9, ISL1, NKX6-2, SPAG6, ZIC1 and ZNF154 were selected for investigation on the basis of previous reports and/or prognostic utility in low/intermediate-grade NMIBC. Methylation was determined by Pyrosequencing of sodium-bisulphite converted DNA, and then correlated with gene expression using RT-qPCR. Methylation was additionally correlated with tumour behaviour, including tumour recurrence and progression to muscle invasive bladder cancer or metastases. Results The ISL1 genes’ promoter-associated island was more frequently methylated in recurrent and progressive high-grade tumours than their non-recurrent counterparts (60.0% vs. 18.2%, p = 0.008). ISL1 and HOXA9 showed significantly higher mean methylation in recurrent and progressive tumours compared to non-recurrent tumours (43.3% vs. 20.9%, p = 0.016 and 34.5% vs 17.6%, p = 0.017, respectively). Concurrent ISL1/HOXA9 methylation in HG-NMIBC reliably predicted tumour recurrence and progression within one year (Positive Predictive Value 91.7%), and was associated with disease-specific mortality (DSM). Conclusions In this study we report methylation differences and similarities between clinical sub-types of high-grade NMIBC. We report the potential ability of methylation biomarkers, at initial diagnosis, to predict tumour recurrence and progression within one year of diagnosis. We found that specific biomarkers reliably predict disease outcome and therefore may help guide patient treatment despite the unpredictable clinical course and heterogeneity of high-grade NMIBC. Further investigation is required, including validation in a larger patient cohort, to confirm the clinical utility of methylation biomarkers in high-grade NMIBC. PMID:26332997

Toward a critical approach to the study of learning environments in science classrooms

NASA Astrophysics Data System (ADS)

Lorsbach, Anthony; Tobin, Kenneth

1995-03-01

Traditional learning environment research in science classrooms has been built on survey methods meant to measure students' and teachers' perceptions of variables used to define the learning environment. This research has led mainly to descriptions of learning environments. We argue that learning environment research should play a transformative role in science classrooms; that learning environment research should take into account contemporary post-positivist ways of thinking about learning and teaching to assist students and teachers to construct a more emancipatory learning environment. In particular, we argue that a critical perspective could lead to research playing a larger role in the transformation of science classroom learning environments. This argument is supplemented with an example from a middle school science classroom.

Distribution of the invasive bryozoan Schizoporella japonica in Great Britain and Ireland and a review of its European distribution.

PubMed

Loxton, J; Wood, C A; Bishop, J D D; Porter, J S; Spencer Jones, M; Nall, C R

2017-01-01

The bryozoan Schizoporella japonica Ortmann (1890) was first recorded in European waters in 2010 and has since been reported from further locations in Great Britain (GB) and Norway. This paper provides a new earliest European record for the species from 2009, a first record from Ireland and presence and absence records from a total of 231 marinas and harbours across GB, Ireland, the Isle of Man, France and Portugal. This species is typically associated with human activity, including commercial and recreational vessels, aquaculture equipment, and both wave and tidal energy devices. It has also been observed in the natural environment, fouling rocks and boulders. The species has an extensive but widely discontinuous distribution in GB and Ireland. Although found frequently in marinas and harbours in Scotland, it inhabits only a few sites in England, Wales and Ireland, interspersed with wide gaps that are well documented as genuine absences. This appears to be a rare example of a southward-spreading invasion in GB and Ireland. The species has been reported from the Isle of Man and Norway but has not been found in France or Portugal. In the future we expect S. japonica to spread into suitable sections of the English, Welsh and Irish coasts, and further within Europe. The species' capability for long-distance saltatory spread and potential for negative impact on native ecosystems and economic activity suggests that S. japonica should now be considered invasive in GB and Ireland. As such, it is recommended that biosecurity procedures alongside effective surveillance and monitoring should be prioritised for regions outside the species' current distribution.

Low {delta}{sup 18}O magma, Isle of Skye, Scotland: Evidence from zircons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gilliam, C.E.; Valley, J.W.

1997-12-01

Zircons in Tertiary granitic rocks from the Isle of Skye, Scotland were resistant to measurable oxygen isotope exchange during intense hydrothermal activity in the subvolcanic environment. Five granite bodies from the Western Red Hills complex were investigated; four have {sup 18}O (Zrc) = 4.1 {+-} 0.2{per_thousand} (VSMOW) while the fifth, which intruded before major cauldron subsidence, is 2{per_thousand} lower. Zircons from Lewisian gneiss are visually and isotopically distinct indicating that zircons in the granite are not xenocrysts from the Lewisian basement. Analysis of different magnetic and size fractions of zircon shows no significant correlation to {delta}{sup 18}O supporting the conclusionmore » that these values represent the true magmatic compositions and that the Western Red Hills granites intruded as low {delta}{sup 18}O magmas with a whole rock {delta}{sup 18}O {le} 6.0%. Quartz separates from four granites are close to the calculated magmatic values in {delta}{sup 18}O, but in the fifth, values are 5% lower indicating variable exchange of quartz with low {delta}{sup 18}O heated meteoric waters. These results might be explained by magmatic interaction with hydrothermally altered crust early in the evolution of the granites, before crystallization of zircon, followed by interaction with later hydrothermal fluids. Alternatively, independent evidence for low {delta}{sup 18}O mafic magmatism in NW Scotland suggests the presence of large quantities of low {delta}{sup 18}O subducted ocean crust in the subcontinental lithosphere that could contaminate or be the source of low {delta}{sup 18}O mantle-derived melts. 31 refs., 4 figs., 1 tab.« less

An Examination through Conjoint Analysis of the Preferences of Students Concerning Online Learning Environments According to Their Learning Styles

ERIC Educational Resources Information Center

Daghan, Gökhan; Akkoyunlu, Buket

2012-01-01

This study examines learning styles of students receiving education via online learning environments, and their preferences concerning the online learning environment. Maggie McVay Lynch Learning Style Inventory was used to determine learning styles of the students. The preferences of students concerning online learning environments were detected…

Archive of digital CHIRP seismic reflection data collected during USGS cruise 06SCC01 offshore of Isles Dernieres, Louisiana, June 2006

USGS Publications Warehouse

Harrison, Arnell S.; Dadisman, Shawn V.; Ferina, Nick F.; Wiese, Dana S.; Flocks, James G.

2007-01-01

In June of 2006, the U.S. Geological Survey conducted a geophysical survey offshore of Isles Dernieres, Louisiana. This report serves as an archive of unprocessed digital CHIRP seismic reflection data, trackline maps, navigation files, GIS information, Field Activity Collection System (FACS) logs, observer's logbook, and formal FGDC metadata. Gained digital images of the seismic profiles are also provided. The archived trace data are in standard Society of Exploration Geophysicists (SEG) SEG-Y format (Barry and others, 1975) and may be downloaded and processed with commercial or public domain software such as Seismic UNIX (SU). Example SU processing scripts and USGS software for viewing the SEG-Y files (Zihlman, 1992) are also provided.

Camping impact management at Isle Royale National Park: an evaluation of visitor activity containment policies from the perspective of social conditions

USGS Publications Warehouse

Farrell, T.A.; Marion, J.L.

2000-01-01

A survey of backcountry and wilderness campsites at Isle Royale National Park reveals that the park?s policies for managing visitor impacts have been remarkably effective in limiting the areal extent of camping-related disturbance. However, the dense spatial arrangement of designated campsites within backcountry campgrounds has also contributed to problems with visitor crowding and conflict. Only 9% of the sites had no other sites visible, while 22% had three or more other sites visible. Mean intersite distance was only 76 feet, and 34% of the sites are within 50 feet of another site. Visitor education programs and selected relocation of sites could reduce these social problems.

Digital Photonic Production of Micro Structures in Glass by In-Volume Selective Laser-Induced Etching using a High Speed Micro Scanner

NASA Astrophysics Data System (ADS)

Gottmann, Jens; Hermans, Martin; Ortmann, Jürgen

Digital photonic production of 3D microfluidic devices and assembled micro mechanics inside fused silica glass is carried out using ISLE directly from digital CAD data. To exploit the potential productivity of new high average power fs-lasers >150 W a modular high speed scanning system has been developed. Acousto-optical beam deflection, galvo-scanners and translation stages are controlled by CAM software. Using a lens with 10 mm focal length a focus radius of 1 μm is scanned with a velocity of 12 m/s on 400 μm track radius enabling the up-scaling of the ISLE- process using fs-laser radiation with up to 30 W.

Caudal dysgenesis in islet-1 transgenic mice

PubMed Central

Muller, Yunhua Li; Yueh, Yir Gloria; Yaworsky, Paul J.; Salbaum, J. Michael; Kappen, Claudia

2014-01-01

Maternal diabetes during pregnancy is responsible for the occurrence of diabetic embryopathy, a spectrum of birth defects that includes heart abnormalities, neural tube defects, and caudal dysgenesis syndromes. Here, we report that mice transgenic for the homeodomain transcription factor Isl-1 develop profound caudal growth defects that resemble human sacral/caudal agenesis. Isl-1 is normally expressed in the pancreas and is required for pancreas development and endocrine cell differentiation. Aberrant regulation of this pancreatic transcription factor causes increased mesodermal cell death, and the severity of defects is dependent on transgene dosage. Together with the finding that mutation of the pancreatic transcription factor HLXB9 causes sacral agenesis, our results implicate pancreatic transcription factors in the pathogenesis of birth defects associated with diabetes. PMID:12738808

Population Structure and Abundance of Arsenite-Oxidizing Bacteria along an Arsenic Pollution Gradient in Waters of the Upper Isle River Basin, France▿ †

PubMed Central

Quéméneur, Marianne; Cébron, Aurélie; Billard, Patrick; Battaglia-Brunet, Fabienne; Garrido, Francis; Leyval, Corinne; Joulian, Catherine

2010-01-01

Denaturing gradient gel electrophoresis (DGGE) and quantitative real-time PCR (qPCR) were successfully developed to monitor functional aoxB genes as markers of aerobic arsenite oxidizers. DGGE profiles showed a shift in the structure of the aoxB-carrying bacterial population, composed of members of the Alpha-, Beta- and Gammaproteobacteria, depending on arsenic (As) and Eh levels in Upper Isle River Basin waters. The highest aoxB gene densities were found in the most As-polluted oxic surface waters but without any significant correlation with environmental factors. Arsenite oxidizers seem to play a key role in As mobility in As-impacted waters. PMID:20453153

Analysis of the nucleoprotein gene identifies three distinct lineages of viral haemorrhagic septicemia virus (VHSV) within the European marine environment

USGS Publications Warehouse

Snow, M.; Cunningham, C.O.; Melvin, W.T.; Kurath, G.

1999-01-01

A ribonuclease (RNase) protection assay (RPA) has been used to detect nucleotide sequence variation within the nucleoprotein gene of 39 viral haemorrhagic septicaemia virus (VHSV) isolates of European marine origin. The classification of VHSV isolates based on RPA cleavage patterns permitted the identification of ten distinct groups of viruses based on differences at the molecular level. The nucleotide sequence of representatives of each of these groupings was determined and subjected to phylogenetic analysis. This revealed grouping of the European marine isolates of VHSV into three genotypes circulating within distinct geographic areas. A fourth genotype was identified comprising isolates originating from North America. Phylogenetic analyses indicated that VHSV isolates recovered from wild caught fish around the British Isles were genetically related to isolates responsible for losses in farmed turbot. Furthermore, a relationship between naturally occurring marine isolates and VHSV isolates causing mortality among rainbow trout in continental Europe was demonstrated. Analysis of the nucleoprotein gene identifies distinct lineages of viral haemorrhagic septicaemia virus within the European marine environment. Virus Res. 63, 35-44. Available from: 

Ambulation During Periods of Supersaturation Increase Decompression Stress in Spacewalk Simulations

NASA Technical Reports Server (NTRS)

Pollock, N. W.; Natoli, M. J.; Martina, S. D.; Conkin, J.; Wessel, J. H., III; Gernhardt, M. L.

2016-01-01

Musculoskeletal activity accelerates inert gas elimination during oxygen breathing prior to decompression (prebreathe), but may also promote bubble formation (nucleation) and increase the risk of decompression sickness (DCS). The timing, pattern and intensity of musculoskeletal activity and the level of tissue supersaturation are likely critical to the net effect. Understanding the relationships is important to evaluate exercise prebreathe protocols and quantify decompression risk in gravity and microgravity environments. The NASA Prebreathe Reduction Program (PRP) combined oxygen prebreathe and exercise preceding a low pressure (4.3 psia; altitude equivalent of 30,300 ft [9,235 m]) simulation exposure of non-ambulatory subjects (a microgravity analog) to produce two protocols now used by astronauts preparing for extravehicular activity. One protocol included both upright cycling and non-cycling exercise (CEVIS: 'cycle ergometer vibration isolation system') and one protocol relied on non-cycling exercise only (ISLE: 'in-suit light exercise'). CEVIS trial data serve as control data for the current study to investigate the influence of ambulation exercise in 1G environments on bubble formation and the subsequent risk of DCS.

Pre-Service English Teachers in Blended Learning Environment in Respect to Their Learning Approaches

ERIC Educational Resources Information Center

Yilmaz, M. Betul; Orhan, Feza

2010-01-01

Blended learning environment (BLE) is increasingly used in the world, especially in university degrees and it is based on integrating web-based learning and face-to-face (FTF) learning environments. Besides integrating different learning environments, BLE also addresses to students with different learning approaches. The "learning…

Toxecon Retrofit for Mercury and Mulit-Pollutant Control on Three 90-MW Coal-Fired Boilers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steven Derenne; Robin Stewart

2009-09-30

This U.S. Department of Energy (DOE) Clean Coal Power Initiative (CCPI) project was based on a cooperative agreement between We Energies and the DOE Office of Fossil Energy's National Energy Technology Laboratory (NETL) to design, install, evaluate, and demonstrate the EPRI-patented TOXECON{trademark} air pollution control process. Project partners included Cummins & Barnard, ADA-ES, and the Electric Power Research Institute (EPRI). The primary goal of this project was to reduce mercury emissions from three 90-MW units that burn Powder River Basin coal at the We Energies Presque Isle Power Plant in Marquette, Michigan. Additional goals were to reduce nitrogen oxide (NO{submore » x}), sulfur dioxide (SO{sub 2}), and particulate matter emissions; allow reuse and sale of fly ash; advance commercialization of the technology; demonstrate a reliable mercury continuous emission monitor (CEM) suitable for use at power plants; and demonstrate recovery of mercury from the sorbent. Mercury was controlled by injection of activated carbon upstream of the TOXECON{trademark} baghouse, which achieved more than 90% removal on average over a 44-month period. During a two-week test involving trona injection, SO{sub 2} emissions were reduced by 70%, although no coincident removal of NOx was achieved. The TOXECON{trademark} baghouse also provided enhanced particulate control, particularly during startup of the boilers. On this project, mercury CEMs were developed and tested in collaboration with Thermo Fisher Scientific, resulting in a reliable CEM that could be used in the power plant environment and that could measure mercury as low as 0.1 {micro}g/m{sup 3}. Sorbents were injected downstream of the primary particulate collection device, allowing for continued sale and beneficial use of captured fly ash. Two methods for recovering mercury using thermal desorption on the TOXECON{trademark} PAC/ash mixture were successfully tested during this program. Two methods for using the TOXECON{trademark} PAC/ash mixture in structural concrete were also successfully developed and tested. This project demonstrated a significant reduction in the rate of emissions from Presque Isle Units 7, 8, and 9, and substantial progress toward establishing the design criteria for one of the most promising mercury control retrofit technologies currently available. The Levelized Cost for 90% mercury removal at this site was calculated at $77,031 per pound of mercury removed with a capital cost of $63,189 per pound of mercury removed. Mercury removal at the Presque Isle Power Plant averages approximately 97 pounds per year.« less

Integrating Learning, Problem Solving, and Engagement in Narrative-Centered Learning Environments

ERIC Educational Resources Information Center

Rowe, Jonathan P.; Shores, Lucy R.; Mott, Bradford W.; Lester, James C.

2011-01-01

A key promise of narrative-centered learning environments is the ability to make learning engaging. However, there is concern that learning and engagement may be at odds in these game-based learning environments. This view suggests that, on the one hand, students interacting with a game-based learning environment may be engaged but unlikely to…

Factors Influencing Learning Environments in an Integrated Experiential Program

NASA Astrophysics Data System (ADS)

Koci, Peter

The research conducted for this dissertation examined the learning environment of a specific high school program that delivered the explicit curriculum through an integrated experiential manner, which utilized field and outdoor experiences. The program ran over one semester (five months) and it integrated the grade 10 British Columbian curriculum in five subjects. A mixed methods approach was employed to identify the students' perceptions and provide richer descriptions of their experiences related to their unique learning environment. Quantitative instruments were used to assess changes in students' perspectives of their learning environment, as well as other supporting factors including students' mindfulness, and behaviours towards the environment. Qualitative data collection included observations, open-ended questions, and impromptu interviews with the teacher. The qualitative data describe the factors and processes that influenced the learning environment and give a richer, deeper interpretation which complements the quantitative findings. The research results showed positive scores on all the quantitative measures conducted, and the qualitative data provided further insight into descriptions of learning environment constructs that the students perceived as most important. A major finding was that the group cohesion measure was perceived by students as the most important attribute of their preferred learning environment. A flow chart was developed to help the researcher conceptualize how the learning environment, learning process, and outcomes relate to one another in the studied program. This research attempts to explain through the consideration of this case study: how learning environments can influence behavioural change and how an interconnectedness among several factors in the learning process is influenced by the type of learning environment facilitated. Considerably more research is needed in this area to understand fully the complexity learning environments and how they influence learning and behaviour. Keywords: learning environments; integrated experiential programs; environmental education.

Hypermedia in Vocational Learning: A Hypermedia Learning Environment for Training Management Skills

ERIC Educational Resources Information Center

Konradt, Udo

2004-01-01

A learning environment is defined as an arrangement of issues, methods, techniques, and media in a given domain. Besides temporal and spatial features a learning environment considers the social situation in which learning takes place. In (hypermedia) learning environments the concept of exploration and the active role of the learner is…

Using Wikis as a Support and Assessment Tool in Collaborative Digital Game-Based Learning Environments

ERIC Educational Resources Information Center

Samur, Yavuz

2011-01-01

In computer-supported collaborative learning (CSCL) environments, there are many researches done on collaborative learning activities; however, in game-based learning environments, more research and literature on collaborative learning activities are required. Actually, both game-based learning environments and wikis enable us to use new chances…

Assessing culturally sensitive factors in the learning environment of science classrooms

NASA Astrophysics Data System (ADS)

Fisher, Darrell L.; Waldrip, Bruce G.

1997-03-01

As schools are becoming increasingly diverse in their scope and clientele, any examination of the interaction of culturally sensitive factors of students' learning environments with learning science assumes critical importance. The purpose of this exploratory study was to develop an instrument to assess learning environment factors that are culturally sensitive, to provide initial validation information on the instrument and to examine associations between students' perceptions of their learning environments and their attitudes towards science and achievement of enquiry skills. A measure of these factors of science student's learning environment, namely the Cultural Learning Environment Questionnaire (CLEQ), was developed from past learning environment instruments and influenced by Hofstede's four dimensions of culture (Power Distance, Uncertainty Avoidance, Individualism, and Masculinity/Femininity). The reliability and discriminant validity for each scale were obtained and associations between learning environment, attitude to science and enquiry skills achievement were found.

Massive sediment bypassing on the lower shoreface offshore of a wide tidal inlet: Cat Island Pass, Louisiana

USGS Publications Warehouse

Jaffe, B.E.; List, J.H.; Sallenger, A.H.

1997-01-01

Analysis of a series of historical bathymetric and shoreline surveys along the Louisiana coast west of the Mississippi River mouth detected a large area of deposition in water depths of 2.0–8.5 m offshore of a 9-km-wide tidal inlet, the Cat Island Pass/Wine Island Pass system. A 59.9 · 106 m3 sandy deposit formed from the 1930s–1980s, spanning 27 km in the alongshore direction, delineating the transport pathway for sediment bypassing offshore of the inlet on the shoreface. Bypassing connected the shorefaces of two barrier island systems, the Isles Dernieres and the Bayou Lafourche.The processes responsible for formation of this deposit are not well understood, but sediment-transport modeling suggests that sediment is transported primarily by wind-driven coastal currents during large storms and hurricanes. Deposition appears to be related to changes in shoreline orientation, closing of transport pathways into a large bay to the east and the presence of tidal inlets. This newly documented type of bypassing, an offshore bypassing of the inlet system, naturally nourished the immediate downdrift area, the eastern Isles Dernieres, where shoreface and shoreline erosion rates are about half of pre-bypassing rates. Erosion rates remained the same farther downdrift, where bypassing has not yet reached. As this offshore bypassing continues, the destruction of the Isles Dernieres will be slowed.

Factoring uncertainty into restoration modeling of in-situ leach uranium mines

USGS Publications Warehouse

Johnson, Raymond H.; Friedel, Michael J.

2009-01-01

Postmining restoration is one of the greatest concerns for uranium in-situ leach (ISL) mining operations. The ISL-affected aquifer needs to be returned to conditions specified in the mining permit (either premining or other specified conditions). When uranium ISL operations are completed, postmining restoration is usually achieved by injecting reducing agents into the mined zone. The objective of this process is to restore the aquifer to premining conditions by reducing the solubility of uranium and other metals in the ground water. Reactive transport modeling is a potentially useful method for simulating the effectiveness of proposed restoration techniques. While reactive transport models can be useful, they are a simplification of reality that introduces uncertainty through the model conceptualization, parameterization, and calibration processes. For this reason, quantifying the uncertainty in simulated temporal and spatial hydrogeochemistry is important for postremedial risk evaluation of metal concentrations and mobility. Quantifying the range of uncertainty in key predictions (such as uranium concentrations at a specific location) can be achieved using forward Monte Carlo or other inverse modeling techniques (trial-and-error parameter sensitivity, calibration constrained Monte Carlo). These techniques provide simulated values of metal concentrations at specified locations that can be presented as nonlinear uncertainty limits or probability density functions. Decisionmakers can use these results to better evaluate environmental risk as future metal concentrations with a limited range of possibilities, based on a scientific evaluation of uncertainty.

Melanocortin 1 receptor (MC1R) gene sequence variation and melanism in the gray (Sciurus carolinensis), fox (Sciurus niger), and red (Sciurus vulgaris) squirrel.

PubMed

McRobie, Helen R; King, Linda M; Fanutti, Cristina; Coussons, Peter J; Moncrief, Nancy D; Thomas, Alison P M

2014-01-01

Sequence variations in the melanocortin 1 receptor (MC1R) gene are associated with melanism in many different species of mammals, birds, and reptiles. The gray squirrel (Sciurus carolinensis), found in the British Isles, was introduced from North America in the late 19th century. Melanism in the British gray squirrel is associated with a 24-bp deletion in the MC1R. To investigate the origin of this mutation, we sequenced the MC1R of 95 individuals including 44 melanic gray squirrels from both the British Isles and North America. Melanic gray squirrels of both populations had the same 24-bp deletion associated with melanism. Given the significant deletion associated with melanism in the gray squirrel, we sequenced the MC1R of both wild-type and melanic fox squirrels (Sciurus niger) (9 individuals) and red squirrels (Sciurus vulgaris) (39 individuals). Unlike the gray squirrel, no association between sequence variation in the MC1R and melanism was found in these 2 species. We conclude that the melanic gray squirrel found in the British Isles originated from one or more introductions of melanic gray squirrels from North America. We also conclude that variations in the MC1R are not associated with melanism in the fox and red squirrels.

Locum tenens consultant doctors in a rural general hospital - an essential part of the medical workforce or an expensive stopgap?

PubMed

Sim, Andrew Jw

2011-01-01

Maintaining hospital consultant staffing levels often requires the employment of locum tenens to meet service needs. This is particularly so in hospitals where core clinical services are run by a small number of permanently appointed consultants. The problems associated with locum employment are underestimated and little attention has been directed towards addressing the issue in the rural general hospitals of Scotland. This study looked at the permanent and short- and long-term locum consultant usage over an 8 year period in one Scottish rural general hospital, the Western Isles Hospital in Stornoway. Data were extracted from the Human Resources Department of NHS Western Isles' list of locum consultants for most weeks from the beginning of January 2002 to the end of December 2009. The Western Isles Hospital in Stornoway has an establishment of 17 permanent consultants. During the 8 year study period 239 different consultants were employed, 20 held substantive permanent positions, 31 were long-term locums (employed >3 months) and 188 were short-term locums. The short-term locums worked for 535 different locum episodes. The pattern of usage varied according to service configuration. Study data revealed the alarming scope of the locum tenens issue, which will increase unless action is taken. For sustainable medical services to continue in the rural general hospitals of Scotland, staffing models must minimise the need to employ locum consultants.

Abnormal chemical element concentrations in lichens of Isle Royale National Park

USGS Publications Warehouse

Bennett, J.P.

1995-01-01

Lichens have been used for many years to monitor changes in deposited airborne chemical elements in many areas, but few studies have focused on areas suspected of experiencing slightly elevated pollution. Detection of subtle patterns of slightly elevated pollutants calls for developing several lines of evidence as opposed to single line studies used in heavily polluted areas. This study of two lichen species, Hypogymnia physodes and Evernia mesomorpha, in Isle Royale National Park, Michigan compares the concentrations and ranks of elements with the concentrations and ranks of the elements in the earth's crust, changes in element concentrations over a nine year period, and the geography of element concentrations in the park. S, Zn, Pb, Cd and Se were elevated in both species and higher in rank compared to the concentrations and ranks in the earth's crust. Toxic elements increased 123% in Hypogymnia and 62% in Evernia over 9 years, compared to increases of 45% and 59% for non-toxic elements in each species, respectively. Geographically, the lichens at certain localities with higher exposures experienced higher than average element concentrations. Finally, tissue concentrations of Mn, S and Se at some localities were above levels known to be either toxic or similar to those found in polluted areas. These four lines of evidence suggest that Isle Royale National Park is experiencing the onset of chronic air pollution stress from a number of sources.

Perceived nuisance of mosquitoes on the Isle of Sheppey, Kent, UK.

PubMed

Hutchinson, Robert A; Lindsay, Steve W

2006-09-01

Little is known about the biting nuisance of mosquitoes in the UK, despite the high numbers found in some locations. A telephone questionnaire survey was used to determine the perceived nuisance of biting insects on the Isle of Sheppey, Kent, a place notorious for mosquitoes. Two hundred randomly selected individuals were interviewed and asked if they suffered from mosquito bites. If they answered yes, they were asked to describe where and when they were bitten, and what measures they took against mosquitoes. Forty-six percent of respondents completed the questionnaire. Of those, 50% reported being bitten by mosquitoes, mostly outside during the summer. Seventy percent said that most biting occurred during the evening and night. Of those respondents who protected themselves against biting (27), most used repellents (70%), with the remainder changing their behaviour to avoid mosquitoes, including closing or screening windows (33%), wearing thicker clothes (7%) and spraying insecticide (4%). One person slept under a bednet in summer (4%). This study provides evidence that on the Isle of Sheppey mosquitoes are considered a major nuisance by a sizeable proportion of the population. Since there is growing interest in the threat posed by new and emerging diseases in the UK, health authorities will need to make substantial efforts to inform and reassure the public about the threats posed by mosquitoes in areas where they are common.

Relationship between learning environment characteristics and academic engagement.

PubMed

Opdenakker, Marie-Christine; Minnaert, Alexander

2011-08-01

The relationship between learning environment characteristics and academic engagement of 777 Grade 6 children located in 41 learning environments was explored. Questionnaires were used to tap learning environment perceptions of children, their academic engagement, and their ethnic-cultural background. The basis of the learning environment questionnaire was the International System for Teacher Observation and Feedback (ISTOF). Factor analysis indicated three factors: the teacher as a helpful and good instructor (having good instructional skills, clear instruction), the teacher as promoter of active learning and differentiation, and the teacher as manager and organizer of classroom activities. Multilevel analysis indicated that about 12% of the differences in engagement between children was related to the learning environment. All the mentioned learning environment characteristics mattered, but the teacher as a helpful, good instructor was most important followed by the teacher as promoter of active learning and differentiation.

Nigerian Physiotherapy Clinical Students' Perception of Their Learning Environment Measured by the Dundee Ready Education Environment Measure Inventory

ERIC Educational Resources Information Center

Odole, Adesola C.; Oyewole, Olufemi O.; Ogunmola, Oluwasolape T.

2014-01-01

The identification of the learning environment and the understanding of how students learn will help teacher to facilitate learning and plan a curriculum to achieve the learning outcomes. The purpose of this study was to investigate undergraduate physiotherapy clinical students' perception of University of Ibadan's learning environment. Using the…

Environmental effects on fish neural plasticity and cognition.

PubMed

Ebbesson, L O E; Braithwaite, V A

2012-12-01

Most fishes experiencing challenging environments are able to adjust and adapt their physiology and behaviour to help them cope more effectively. Much of this flexibility is supported and influenced by cognition and neural plasticity. The understanding of fish cognition and the role played by different regions of the brain has improved significantly in recent years. Techniques such as lesioning, tract tracing and quantifying changes in gene expression help in mapping specialized brain areas. It is now recognized that the fish brain remains plastic throughout a fish's life and that it continues to be sensitive to environmental challenges. The early development of fish brains is shaped by experiences with the environment and this can promote positive and negative effects on both neural plasticity and cognitive ability. This review focuses on what is known about the interactions between the environment, the telencephalon and cognition. Examples are used from a diverse array of fish species, but there could be a lot to be gained by focusing research on neural plasticity and cognition in fishes for which there is already a wealth of knowledge relating to their physiology, behaviour and natural history, e.g. the Salmonidae. © 2012 The Authors. Journal of Fish Biology © 2012 The Fisheries Society of the British Isles.

Supporting cognitive engagement in a learning-by-doing learning environment: Case studies of participant engagement and social configurations in Kitchen Science Investigators

NASA Astrophysics Data System (ADS)

Gardner, Christina M.

Learning-by-doing learning environments support a wealth of physical engagement in activities. However, there is also a lot of variability in what participants learn in each enactment of these types of environments. Therefore, it is not always clear how participants are learning in these environments. In order to design technologies to support learning in these environments, we must have a greater understanding of how participants engage in learning activities, their goals for their engagement, and the types of help they need to cognitively engage in learning activities. To gain a greater understanding of participant engagement and factors and circumstances that promote and inhibit engagement, this dissertation explores and answers several questions: What are the types of interactions and experiences that promote and /or inhibit learning and engagement in learning-by-doing learning environments? What are the types of configurations that afford or inhibit these interactions and experiences in learning-by-doing learning environments? I explore answers to these questions through the context of two enactments of Kitchen Science Investigators (KSI), a learning-by-doing learning environment where middle-school aged children learn science through cooking from customizing recipes to their own taste and texture preferences. In small groups, they investigate effects of ingredients through the design of cooking and science experiments, through which they experience and learn about chemical, biological, and physical science phenomena and concepts (Clegg, Gardner, Williams, & Kolodner, 2006). The research reported in this dissertation sheds light on the different ways participant engagement promotes and/or inhibits cognitive engagement in by learning-by-doing learning environments through two case studies. It also provides detailed descriptions of the circumstances (social, material, and physical configurations) that promote and/or inhibit participant engagement in these learning environments through cross-case analyses of these cases. Finally, it offers suggestions about structuring activities, selecting materials and resources, and designing facilitation and software-realized scaffolding in the design of these types of learning environments. These design implications focus on affording participant engagement in science content and practices learning. Overall, the case studies, cross-case analyses, and empirically-based design implications begin to bridge the gap between theory and practice in the design and implementation of these learning environments. This is demonstrated by providing detailed and explanatory examples and factors that affect how participants take up the affordances of the learning opportunities designed into these learning environments.

Musics of Oceania

ERIC Educational Resources Information Center

Kennedy, Raymond F.

1972-01-01

Article examines the music and musical instruments of an area commonly referred to as the South Sea Isles. Author also points out the musical function and cultural meaning of specific musical styles. (RK)

Self-adaptive demodulation for polarization extinction ratio in distributed polarization coupling.

PubMed

Zhang, Hongxia; Ren, Yaguang; Liu, Tiegen; Jia, Dagong; Zhang, Yimo

2013-06-20

A self-adaptive method for distributed polarization extinction ratio (PER) demodulation is demonstrated. It is characterized by dynamic PER threshold coupling intensity (TCI) and nonuniform PER iteration step length (ISL). Based on the preset PER calculation accuracy and original distribution coupling intensity, TCI and ISL can be made self-adaptive to determine contributing coupling points inside the polarizing devices. Distributed PER is calculated by accumulating those coupling points automatically and selectively. Two different kinds of polarization-maintaining fibers are tested, and PERs are obtained after merely 3-5 iterations using the proposed method. Comparison experiments with Thorlabs commercial instrument are also conducted, and results show high consistency. In addition, the optimum preset PER calculation accuracy of 0.05 dB is obtained through many repeated experiments.

Narratives of Girls and Boys with Autism Spectrum Disorders: Gender Differences in Narrative Competence and Internal State Language.

PubMed

Kauschke, Christina; van der Beek, Bettina; Kamp-Becker, Inge

2016-03-01

Since gender differences in the symptomatology of autism spectrum disorder (ASD) are not well understood, the current study examines the communicative skills of males and females with ASD. Narrative competence and internal state language (ISL) was investigated using narrations elicited by a wordless picture book. 11 girls and 11 boys with ASD and 11 typically developing girls were individually matched. Although results demonstrate largely comparable narrative skills across groups, the groups differed with respect to the size and use of ISL: Girls with ASD verbalized and motivated internal states more often than boys, and both groups with ASD fell behind typically developing children in production of affective words. Implications for the clinical presentation of males and females with ASD are discussed.

Hostile fire indicator threat data collection for helicopter-mounted applications

NASA Astrophysics Data System (ADS)

Naz, P.; Hengy, S.; De Mezzo, S.

2013-05-01

This paper briefly describes the set-up of the sensors and the instrumentation deployed by the French-German Research Institute of Saint-Louis (ISL) during the last NATO/ACG3/SG2 HFI Threat Data Collection (Trial PROTEUS which has been conducted during the summer 2012 in Slovenia). The main purpose of this trial was the measurements of weapon and ammunition signatures for threat warning and hostile fire indicator (HFI) system development. The used weapons vary from small caliber rifles to anti-tank rockets in ground-to-ground shooting configurations. For the ISL team, the objectives consisted in measuring the acoustic signals for detection and localization of weapon firing events. Experimental results of sound localization obtained by using ground based sensors are presented and analyzed under various conditions.

How People Learn in an Asynchronous Online Learning Environment: The Relationships between Graduate Students' Learning Strategies and Learning Satisfaction

ERIC Educational Resources Information Center

Choi, Beomkyu

2016-01-01

The purpose of this study was to examine the relationships between learners' learning strategies and learning satisfaction in an asynchronous online learning environment. In an attempt to shed some light on how people learn in an online learning environment, one hundred and sixteen graduate students who were taking online learning courses…

Scaffolding in Connectivist Mobile Learning Environment

ERIC Educational Resources Information Center

Ozan, Ozlem

2013-01-01

Social networks and mobile technologies are transforming learning ecology. In this changing learning environment, we find a variety of new learner needs. The aim of this study is to investigate how to provide scaffolding to the learners in connectivist mobile learning environment: (1) to learn in a networked environment; (2) to manage their…

Online Resource-Based Learning Environment: Case Studies in Primary Classrooms

ERIC Educational Resources Information Center

So, Winnie Wing Mui; Ching, Fiona Ngai Ying

2012-01-01

This paper discusses the creation of learning environments with online resources by three primary school teachers for pupil's learning of science-related topics with reference to the resource-based e-learning environments (RBeLEs) framework. Teachers' choice of contexts, resources, tools, and scaffolds in designing the learning environments are…

The Predicaments of Language Learners in Traditional Learning Environments

ERIC Educational Resources Information Center

Shafie, Latisha Asmaak; Mansor, Mahani

2009-01-01

Some public universities in developing countries have traditional language learning environments such as classrooms with only blackboards and furniture which do not provide conducive learning environments. These traditional environments are unable to cater for digital learners who need to learn with learning technologies. In order to create…

The Integration of Personal Learning Environments & Open Network Learning Environments

ERIC Educational Resources Information Center

Tu, Chih-Hsiung; Sujo-Montes, Laura; Yen, Cherng-Jyh; Chan, Junn-Yih; Blocher, Michael

2012-01-01

Learning management systems traditionally provide structures to guide online learners to achieve their learning goals. Web 2.0 technology empowers learners to create, share, and organize their personal learning environments in open network environments; and allows learners to engage in social networking and collaborating activities. Advanced…

Experiential Learning and Learning Environments: The Case of Active Listening Skills

ERIC Educational Resources Information Center

Huerta-Wong, Juan Enrique; Schoech, Richard

2010-01-01

Social work education research frequently has suggested an interaction between teaching techniques and learning environments. However, this interaction has never been tested. This study compared virtual and face-to-face learning environments and included active listening concepts to test whether the effectiveness of learning environments depends…

The Role of the Constructivist Learning Theory and Collaborative Learning Environment on Wiki Classroom, and the Relationship between Them

ERIC Educational Resources Information Center

Alzahrani, Ibraheem; Woollard, John

2013-01-01

This paper seeks to discover the relationship between both the social constructivist learning theory and the collaborative learning environment. This relationship can be identified by giving an example of the learning environment. Due to wiki characteristics, Wiki technology is one of the most famous learning environments that can show the…

Practice education learning environments: the mismatch between perceived and preferred expectations of undergraduate health science students.

PubMed

Brown, Ted; Williams, Brett; McKenna, Lisa; Palermo, Claire; McCall, Louise; Roller, Louis; Hewitt, Lesley; Molloy, Liz; Baird, Marilyn; Aldabah, Ligal

2011-11-01

Practical hands-on learning opportunities are viewed as a vital component of the education of health science students, but there is a critical shortage of fieldwork placement experiences. It is therefore important that these clinical learning environments are well suited to students' perceptions and expectations. To investigate how undergraduate students enrolled in health-related education programs view their clinical learning environments and specifically to compare students' perception of their 'actual' clinical learning environment to that of their 'preferred/ideal' clinical learning environment. The Clinical Learning Environment Inventory (CLEI) was used to collect data from 548 undergraduate students (55% response rate) enrolled in all year levels of paramedics, midwifery, radiography and medical imaging, occupational therapy, pharmacy, nutrition and dietetics, physiotherapy and social work at Monash University via convenience sampling. Students were asked to rate their perception of the clinical learning environment at the completion of their placements using the CLEI. Satisfaction of the students enrolled in the health-related disciplines was closely linked with the five constructs measured by the CLEI: Personalization, Student Involvement, Task Orientation, Innovation, and Individualization. Significant differences were found between the student's perception of their 'actual' clinical learning environment and their 'ideal' clinical learning environment. The study highlights the importance of a supportive clinical learning environment that places emphasis on effective two-way communication. A thorough understanding of students' perceptions of their clinical learning environments is essential. Copyright © 2010 Elsevier Ltd. All rights reserved.

Applying a Framework for Student Modeling in Exploratory Learning Environments: Comparing Data Representation Granularity to Handle Environment Complexity

ERIC Educational Resources Information Center

Fratamico, Lauren; Conati, Cristina; Kardan, Samad; Roll, Ido

2017-01-01

Interactive simulations can facilitate inquiry learning. However, similarly to other Exploratory Learning Environments, students may not always learn effectively in these unstructured environments. Thus, providing adaptive support has great potential to help improve student learning with these rich activities. Providing adaptive support requires a…

A Simultaneous Mobile E-Learning Environment and Application

ERIC Educational Resources Information Center

Karal, Hasan; Bahcekapili, Ekrem; Yildiz, Adil

2010-01-01

The purpose of the present study was to design a mobile learning environment that enables the use of a teleconference application used in simultaneous e-learning with mobile devices and to evaluate this mobile learning environment based on students' views. With the mobile learning environment developed in the study, the students are able to follow…

Using Scenarios to Design Complex Technology-Enhanced Learning Environments

ERIC Educational Resources Information Center

de Jong, Ton; Weinberger, Armin; Girault, Isabelle; Kluge, Anders; Lazonder, Ard W.; Pedaste, Margus; Ludvigsen, Sten; Ney, Muriel; Wasson, Barbara; Wichmann, Astrid; Geraedts, Caspar; Giemza, Adam; Hovardas, Tasos; Julien, Rachel; van Joolingen, Wouter R.; Lejeune, Anne; Manoli, Constantinos C.; Matteman, Yuri; Sarapuu, Tago; Verkade, Alex; Vold, Vibeke; Zacharia, Zacharias C.

2012-01-01

Science Created by You (SCY) learning environments are computer-based environments in which students learn about science topics in the context of addressing a socio-scientific problem. Along their way to a solution for this problem students produce many types of intermediate products or learning objects. SCY learning environments center the entire…

Construction of a 40-mile long roadside scale model of the solar system in northern Maine

NASA Astrophysics Data System (ADS)

McCartney, K.

2001-05-01

The Maine Solar System Model is currently under construction along Route 1 between Houlton and Presque Isle, in Aroostook County, northern Maine. The scale is 1:93,000,000, or 1 mile equals an astronomical unit. There is a 40 mile distance between the Sun (diameter 49.5 feet) and Pluto (diameter 1 inch). The model will include the Sun, nine planets and seven moons, with diameters and distances all to the same scale. Except for the Sun, all components will be three-dimensional and built to withstand the northern Maine climate. Construction is generally of steel with fiberglass globes positioned on steel posts at least ten feet above ground and 55 feet off the roadway. Road safety concerns require that the Jupiter and Saturn sites include parking lots. Educational information associated with the model will be provided on brochures, since textual information at the sites would require excessive stops and parking problems. Learning exercises will also be provided by travelling trunks prepared by Maine teachers to support the State of Maine Learning Results. This is a community project with the various components being built by ten area schools and with active assistance from many community members and organizations. It is being built with with very little money, with most materials and labor donated.

Learning Environments Designed According to Learning Styles and Its Effects on Mathematics Achievement

ERIC Educational Resources Information Center

Özerem, Aysen; Akkoyunlu, Buket

2015-01-01

Problem Statement: While designing a learning environment it is vital to think about learner characteristics (learning styles, approaches, motivation, interests… etc.) in order to promote effective learning. The learning environment and learning process should be designed not to enable students to learn in the same manner and at the same level,…

Web-Based Learning Environment Based on Students’ Needs

NASA Astrophysics Data System (ADS)

Hamzah, N.; Ariffin, A.; Hamid, H.

2017-08-01

Traditional learning needs to be improved since it does not involve active learning among students. Therefore, in the twenty-first century, the development of internet technology in the learning environment has become the main needs of each student. One of the learning environments to meet the needs of the teaching and learning process is a web-based learning environment. This study aims to identify the characteristics of a web-based learning environment that supports students’ learning needs. The study involved 542 students from fifteen faculties in a public higher education institution in Malaysia. A quantitative method was used to collect the data via a questionnaire survey by randomly. The findings indicate that the characteristics of a web-based learning environment that support students’ needs in the process of learning are online discussion forum, lecture notes, assignments, portfolio, and chat. In conclusion, the students overwhelmingly agreed that online discussion forum is the highest requirement because the tool can provide a space for students and teachers to share knowledge and experiences related to teaching and learning.

Measuring plume-related exhumation of the British Isles in Early Cenozoic times

NASA Astrophysics Data System (ADS)

Cogné, Nathan; Doepke, Daniel; Chew, David; Stuart, Finlay M.; Mark, Chris

2016-12-01

Mantle plumes have been proposed to exert a first-order control on the morphology of Earth's surface. However, there is little consensus on the lifespan of the convectively supported topography. Here, we focus on the Cenozoic uplift and exhumation history of the British Isles. While uplift in the absence of major regional tectonic activity has long been documented, the causative mechanism is highly controversial, and direct exhumation estimates are hindered by the near-complete absence of onshore post-Cretaceous sediments (outside Northern Ireland) and the truncated stratigraphic record of many offshore basins. Two main hypotheses have been developed by previous studies: epeirogenic exhumation driven by the proto-Iceland plume, or multiple phases of Cenozoic compression driven by far-field stresses. Here, we present a new thermochronological dataset comprising 43 apatite fission track (AFT) and 102 (U-Th-Sm)/He (AHe) dates from the onshore British Isles. Inverse modelling of vertical sample profiles allows us to define well-constrained regional cooling histories. Crucially, during the Paleocene, the thermal history models show that a rapid exhumation pulse (1-2.5 km) occurred, focused on the Irish Sea. Exhumation is greatest in the north of the Irish Sea region, and decreases in intensity to the south and west. The spatial pattern of Paleocene exhumation is in agreement with the extent of magmatic underplating inferred from geophysical studies, and the timing of uplift and exhumation is synchronous with emplacement of the plume-related British and Irish Paleogene Igneous Province (BIPIP). Prior to the Paleocene exhumation pulse, the Mesozoic onshore exhumation pulse is mainly linked to the uplift and erosion of the hinterland during the complex and long-lived rifting history of the neighbouring offshore basins. The extent of Neogene exhumation is difficult to constrain due to the poor sensitivity of the AHe and AFT systems at low temperatures. We conclude that the Cenozoic topographic evolution of the British Isles is the result of plume-driven uplift and exhumation, with inversion under compressive stress playing a secondary role.

Distributing vs. Blocking Learning Questions in a Web-Based Learning Environment

ERIC Educational Resources Information Center

Kapp, Felix; Proske, Antje; Narciss, Susanne; Körndle, Hermann

2015-01-01

Effective studying in web-based learning environments (web-LEs) requires cognitive engagement and demands learners to regulate their learning activities. One way to support learners in web-LEs is to provide interactive learning questions within the learning environment. Even though research on learning questions has a long tradition, there are…

Learning with Collaborative Inquiry: A Science Learning Environment for Secondary Students

ERIC Educational Resources Information Center

Sun, Daner; Looi, Chee-Kit; Xie, Wenting

2017-01-01

When inquiry-based learning is designed for a collaborative context, the interactions that arise in the learning environment can become fairly complex. While the learning effectiveness of such learning environments has been reported in the literature, there have been fewer studies on the students' learning processes. To address this, the article…

Learning in a u-Museum: Developing a Context-Aware Ubiquitous Learning Environment

ERIC Educational Resources Information Center

Chen, Chia-Chen; Huang, Tien-Chi

2012-01-01

Context-awareness techniques can support learners in learning without time or location constraints by using mobile devices and associated learning activities in a real learning environment. Enrichment of context-aware technologies has enabled students to learn in an environment that integrates learning resources from both the real world and the…

Assessing the Impact of Student Learning Style Preferences

NASA Astrophysics Data System (ADS)

Davis, Stacey M.; Franklin, Scott V.

2004-09-01

Students express a wide range of preferences for learning environments. We are trying to measure the manifestation of learning styles in various learning environments. In particular, we are interested in performance in an environment that disagrees with the expressed learning style preference, paying close attention to social (group vs. individual) and auditory (those who prefer to learn by listening) environments. These are particularly relevant to activity-based curricula which typically emphasize group-work and de-emphasize lectures. Our methods include multiple-choice assessments, individual student interviews, and a study in which we attempt to isolate the learning environment.

Construction of a Digital Learning Environment Based on Cloud Computing

ERIC Educational Resources Information Center

Ding, Jihong; Xiong, Caiping; Liu, Huazhong

2015-01-01

Constructing the digital learning environment for ubiquitous learning and asynchronous distributed learning has opened up immense amounts of concrete research. However, current digital learning environments do not fully fulfill the expectations on supporting interactive group learning, shared understanding and social construction of knowledge.…

A Well Designed School Environment Facilitates Brain Learning.

ERIC Educational Resources Information Center

Chan, Tak Cheung; Petrie, Garth

2000-01-01

Examines how school design facilitates learning by complementing how the brain learns. How the brain learns is discussed and how an artistic environment, spaciousness in the learning areas, color and lighting, and optimal thermal and acoustical environments aid student learning. School design suggestions conclude the article. (GR)

Students' perception of the learning environment in a distributed medical programme.

PubMed

Veerapen, Kiran; McAleer, Sean

2010-09-24

The learning environment of a medical school has a significant impact on students' achievements and learning outcomes. The importance of equitable learning environments across programme sites is implicit in distributed undergraduate medical programmes being developed and implemented. To study the learning environment and its equity across two classes and three geographically separate sites of a distributed medical programme at the University of British Columbia Medical School that commenced in 2004. The validated Dundee Ready Educational Environment Survey was sent to all students in their 2nd and 3rd year (classes graduating in 2009 and 2008) of the programme. The domains of the learning environment surveyed were: students' perceptions of learning, students' perceptions of teachers, students' academic self-perceptions, students' perceptions of the atmosphere, and students' social self-perceptions. Mean scores, frequency distribution of responses, and inter- and intrasite differences were calculated. The perception of the global learning environment at all sites was more positive than negative. It was characterised by a strongly positive perception of teachers. The work load and emphasis on factual learning were perceived negatively. Intersite differences within domains of the learning environment were more evident in the pioneer class (2008) of the programme. Intersite differences consistent across classes were largely related to on-site support for students. Shared strengths and weaknesses in the learning environment at UBC sites were evident in areas that were managed by the parent institution, such as the attributes of shared faculty and curriculum. A greater divergence in the perception of the learning environment was found in domains dependent on local arrangements and social factors that are less amenable to central regulation. This study underlines the need for ongoing comparative evaluation of the learning environment at the distributed sites and interaction between leaders of these sites.

75 FR 28250 - Ocean Transportation Intermediary License Applicants

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-20

... C. Aitchison, CEO. Application Type: New OFF License. Dapex Inc. (NVO), 83-77 Woodhaven Blvd., Apt.... dba Lars International Freight Forwarders (NVO), 16900 North Bay Road, Apt. 1906, Sunny Isles, FL...

And the Top Honor Goes to Voc Ed.

ERIC Educational Resources Information Center

Hettinger, James

1998-01-01

Ray Chelewski is the first vocational-technical educator to win Walt Disney's top teaching honor. Chelewski is an agriculture teacher at the Presque Isle Regional Technology Center in northeast Maine. (JOW)

Personal Learning Environments: A Solution for Self-Directed Learners

ERIC Educational Resources Information Center

Haworth, Ryan

2016-01-01

In this paper I discuss "personal learning environments" and their diverse benefits, uses, and implications for life-long learning. Personal Learning Environments (PLEs) are Web 2.0 and social media technologies that enable individual learners the ability to manage their own learning. Self-directed learning is explored as a foundation…

Ubiquitous Learning Environments in Higher Education: A Scoping Literature Review

ERIC Educational Resources Information Center

Virtanen, Mari Aulikki; Haavisto, Elina; Liikanen, Eeva; Kääriäinen, Maria

2018-01-01

Ubiquitous learning and the use of ubiquitous learning environments heralds a new era in higher education. Ubiquitous learning environments enhance context-aware and seamless learning experiences available from any location at any time. They support smooth interaction between authentic and digital learning resources and provide personalized…

Co-Regulation of Learning in Computer-Supported Collaborative Learning Environments: A Discussion

ERIC Educational Resources Information Center

Chan, Carol K. K.

2012-01-01

This discussion paper for this special issue examines co-regulation of learning in computer-supported collaborative learning (CSCL) environments extending research on self-regulated learning in computer-based environments. The discussion employs a socio-cognitive perspective focusing on social and collective views of learning to examine how…

Trajectories of the home learning environment across the first 5 years: associations with children's vocabulary and literacy skills at prekindergarten.

PubMed

Rodriguez, Eileen T; Tamis-LeMonda, Catherine S

2011-01-01

Children's home learning environments were examined in a low-income sample of 1,852 children and families when children were 15, 25, 37, and 63 months. During home visits, children's participation in literacy activities, the quality of mothers' engagements with their children, and the availability of learning materials were assessed, yielding a total learning environment score at each age. At 63 months, children's vocabulary and literacy skills were assessed. Six learning environment trajectories were identified, including environments that were consistently low, environments that were consistently high, and environments characterized by varying patterns of change. The skills of children at the extremes of learning environment trajectories differed by more than 1 SD and the timing of learning experiences related to specific emerging skills. © 2011 The Authors. Child Development © 2011 Society for Research in Child Development, Inc.

The Interplay of Perceptions of the Learning Environment, Personality and Learning Strategies: A Study amongst International Business Studies Students

ERIC Educational Resources Information Center

Nijhuis, Jan; Segers, Mien; Gijselaers, Wim

2007-01-01

Previous research on students' learning strategies has examined the relationships between either perceptions of the learning environment or personality and learning strategies. The focus of this study was on the joint relationships between the students' perceptions of the learning environment, their personality, and the learning strategies they…

CLEW: A Cooperative Learning Environment for the Web.

ERIC Educational Resources Information Center

Ribeiro, Marcelo Blois; Noya, Ricardo Choren; Fuks, Hugo

This paper outlines CLEW (collaborative learning environment for the Web). The project combines MUD (Multi-User Dimension), workflow, VRML (Virtual Reality Modeling Language) and educational concepts like constructivism in a learning environment where students actively participate in the learning process. The MUD shapes the environment structure.…

Evaluating and Implementing Learning Environments: A United Kingdom Experience.

ERIC Educational Resources Information Center

Ingraham, Bruce; Watson, Barbara; McDowell, Liz; Brockett, Adrian; Fitzpatrick, Simon

2002-01-01

Reports on ongoing work at five universities in northeastern England that have been evaluating and implementing online learning environments known as virtual learning environments (VLEs) or managed learning environments (MLEs). Discusses do-it-yourself versus commercial systems; transferability; Web-based versus client-server; integration with…

Overhead Door Company of Charleston Information Sheet

EPA Pesticide Factsheets

Overhead Door Company of Charleston (the Company) is located in North Charleston, South Carolina. The settlement involves renovation activities conducted at a property constructed prior to 1978, located in Isle of Palms, South Carolina.

Detonation Product EOS Studies: Using ISLS to Refine Cheetah

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zaug, J M; Howard, W M; Fried, L E

2001-08-08

Knowledge of an effective interatomic potential function underlies any effort to predict or rationalize the properties of solids and liquids. The experiments we undertake are directed towards determination of equilibrium and dynamic properties of simple fluids at densities sufficiently high that traditional computational methods and semi-empirical forms successful at ambient conditions may require reconsideration. In this paper we present high-pressure and temperature experimental sound speed data on a simple fluid, methanol. Impulsive Stimulated Light Scattering (ISLS) conducted on diamond-anvil cell (DAC) encapsulated samples offers an experimental approach to determine cross-pair potential interactions through equation of state determinations. In addition themore » kinetics of structural relaxation in fluids can be studied. We compare our experimental results with our thermochemical computational model Cheetah. Computational models are systematically improved with each addition of experimental data.« less

Trauma on the Isle of Man.

PubMed Central

Hackney, R G; Varley, G; Stevens, D; Green, A

1993-01-01

The Isle of Man Tourist Trophy motorcycle races remain one of the most popular venues for motorcycle races. This is despite the reduced status of the event. The reason for the loss of world championship and formula one status is the nature of the road racing circuit itself. The twisting narrow roads are only closed to the public at certain times during the practice and race weeks. Motorcycling visitors to the event attempt to emulate their heroes on machines capable of high speeds. Casualties from both visitors and racers are dealt with efficiently by an expanded medical service. This includes the use of an aeromedical evacuation helicopter. Casualties from the visitors exceeded those from the racers themselves during the period reported. Images Figure 1 Figure 2 Figure 4 Figure 3 Figure 5 Figure 6 Figure 7 Figure 8 PMID:8457818

Deposition and cycling of sulfur controls mercury accumulation in Isle Royale fish

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paul E. Drevnick; Donald E. Canfield; Patrick R. Gorski

2007-11-01

Mercury contamination of fish is a global problem. Consumption of contaminated fish is the primary route of methylmercury exposure in humans and is detrimental to health. Newly mandated reductions in anthropogenic mercury emissions aim to reduce atmospheric mercury deposition and thus mercury concentrations in fish. However, factors other than mercury deposition are important for mercury bioaccumulation in fish. In the lakes of Isle Royale, U.S.A., reduced rates of sulfate deposition since the Clean Air Act of 1970 have caused mercury concentrations in fish to decline to levels that are safe for human consumption, even without a discernible decrease in mercurymore » deposition. Therefore, reductions in anthropogenic sulfur emissions may provide a synergistic solution to the mercury problem in sulfate-limited freshwaters. 71 refs., 3 figs., 1 tab.« less

Winter Snowfall Turns an Emerald White

NASA Technical Reports Server (NTRS)

2001-01-01

Ireland's climate is normally mild due to the nearby Gulf Stream, but the waning days of 2000 saw the Emerald Isle's green fields swathed in an uncommon blanket of white. The contrast between summer and winter is apparent in this pair of images of southwestern Ireland acquired by MISR's vertical-viewing (nadir) camera on August 23, 2000 (left) and December 29, 2000 (right). The corresponding Terra orbit numbers are 3628 and 5492, respectively.

The year 2000 brought record-breaking weather to the British Isles. England and Wales experienced the wettest spring and autumn months since 1766. Despite being one of the warmest years in recent history, a cold snap arrived between Christmas and New Year's Day. According to the UK Meteorological Office, the 18 centimeters (7 inches) of snow recorded at Aldergrove, Northern Ireland, on December 27-28 was the deepest daily fall since 1930.

Prominent geographical features visible in the MISR images include Galway Bay near the top left. Further south, the mouth of the River Shannon, the largest river in the British Isles, meets the Atlantic Ocean. In the lower portions of the images are the counties of Limerick, Kerry and Cork.

MISR was built and is managed by NASA's Jet Propulsion Laboratory, Pasadena, CA, for NASA's Office of Earth Science, Washington, DC. The Terra satellite is managed by NASA's Goddard Space Flight Center, Greenbelt, MD. JPL is a division of the California Institute of Technology

Group Modeling in Social Learning Environments

ERIC Educational Resources Information Center

Stankov, Slavomir; Glavinic, Vlado; Krpan, Divna

2012-01-01

Students' collaboration while learning could provide better learning environments. Collaboration assumes social interactions which occur in student groups. Social theories emphasize positive influence of such interactions on learning. In order to create an appropriate learning environment that enables social interactions, it is important to…

The clinical learning environment in nursing education: a concept analysis.

PubMed

Flott, Elizabeth A; Linden, Lois

2016-03-01

The aim of this study was to report an analysis of the clinical learning environment concept. Nursing students are evaluated in clinical learning environments where skills and knowledge are applied to patient care. These environments affect achievement of learning outcomes, and have an impact on preparation for practice and student satisfaction with the nursing profession. Providing clarity of this concept for nursing education will assist in identifying antecedents, attributes and consequences affecting student transition to practice. The clinical learning environment was investigated using Walker and Avant's concept analysis method. A literature search was conducted using WorldCat, MEDLINE and CINAHL databases using the keywords clinical learning environment, clinical environment and clinical education. Articles reviewed were written in English and published in peer-reviewed journals between 1995-2014. All data were analysed for recurring themes and terms to determine possible antecedents, attributes and consequences of this concept. The clinical learning environment contains four attribute characteristics affecting student learning experiences. These include: (1) the physical space; (2) psychosocial and interaction factors; (3) the organizational culture and (4) teaching and learning components. These attributes often determine achievement of learning outcomes and student self-confidence. With better understanding of attributes comprising the clinical learning environment, nursing education programmes and healthcare agencies can collaborate to create meaningful clinical experiences and enhance student preparation for the professional nurse role. © 2015 John Wiley & Sons Ltd.

Educational environment and approaches to learning of undergraduate nursing students in an Indonesian school of nursing.

PubMed

Rochmawati, Erna; Rahayu, Gandes Retno; Kumara, Amitya

2014-11-01

The aims of this study were to assess students' perceptions of their educational environment and approaches to learning, and determine if perceptions of learning environment associates with approaches to learning. A survey was conducted to collect data from a regional private university in Indonesia. A total of 232 nursing students completed two questionnaires that measured their perceptions of educational environment and approaches to learning. The measurement was based on Dundee Ready Education Environment Measurement (DREEM) and Approaches and Study Skills Inventory for Students (ASSIST). Five learning environments dimensions and three learning approaches dimensions from two measures were measured. The overall score of DREEM was 131.03/200 (SD 17.04), it was in the range considered to be favourable. The overall score is different significantly between years of study (p value = 0.01). This study indicated that the majority of undergraduate nursing students' adopt strategic approach (n = 139. 59.9%). The finding showed that perceived educational environment significantly associated with approaches to learning. This study implicated the need to maintain conducive learning environment. There is also a need to improve the management of learning activities that reflect the use of student-centered learning. Copyright © 2014 Elsevier Ltd. All rights reserved.

Learning with Hypertext Learning Environments: Theory, Design, and Research.

ERIC Educational Resources Information Center

Jacobson, Michael J.; And Others

1996-01-01

Studied 69 undergraduates who used conceptually-indexed hypertext learning environments with differently structured thematic criss-crossing (TCC) treatments: guided and learner selected. Found that students need explicit modeling and scaffolding support to learn complex knowledge from these learning environments, and considers implications for…

Facilitative and obstructive factors in the clinical learning environment: Experiences of pupil enrolled nurses.

PubMed

Lekalakala-Mokgele, Eucebious; Caka, Ernestine M

2015-03-31

The clinical learning environment is a complex social entity that influences student learning outcomes in the clinical setting. Students can experience the clinical learning environment as being both facilitative and obstructive to their learning. The clinical environment may be a source of stress, creating feelings of fear and anxiety which in turn affect the students' responses to learning. Equally, the environment can enhance learning if experienced positively. This study described pupil enrolled nurses' experiences of facilitative and obstructive factors in military and public health clinical learning settings. Using a qualitative, contextual, exploratory descriptive design, three focus group interviews were conducted until data saturation was reached amongst pupil enrolled nurses in a military School of Nursing. Data analysed provided evidence that acceptance by clinical staff and affordance of self-directed learning facilitated learning. Students felt safe to practise when they were supported by the clinical staff. They felt a sense of belonging when the staff showed an interest in and welcomed them. Learning was obstructed when students were met with condescending comments. Wearing of a military uniform in the public hospital and horizontal violence obstructed learning in the clinical learning environment. Students cannot have effective clinical preparation if the environment is not conducive to and supportive of clinical learning, The study shows that military nursing students experience unique challenges as they are trained in two professions that are hierarchical in nature. The students experienced both facilitating and obstructing factors to their learning during their clinical practice. Clinical staff should be made aware of factors which can impact on students' learning. Policies need to be developed for supporting students in the clinical learning environment.

Science Learning Outcomes in Alignment with Learning Environment Preferences

ERIC Educational Resources Information Center

Chang, Chun-Yen; Hsiao, Chien-Hua; Chang, Yueh-Hsia

2011-01-01

This study investigated students' learning environment preferences and compared the relative effectiveness of instructional approaches on students' learning outcomes in achievement and attitude among 10th grade earth science classes in Taiwan. Data collection instruments include the Earth Science Classroom Learning Environment Inventory and Earth…

Exploring Collaborative Learning Effect in Blended Learning Environments

ERIC Educational Resources Information Center

Sun, Z.; Liu, R.; Luo, L.; Wu, M.; Shi, C.

2017-01-01

The use of new technology encouraged exploration of the effectiveness and difference of collaborative learning in blended learning environments. This study investigated the social interactive network of students, level of knowledge building and perception level on usefulness in online and mobile collaborative learning environments in higher…

A Preliminary Investigation of Self-Directed Learning Activities in a Non-Formal Blended Learning Environment

ERIC Educational Resources Information Center

Schwier, Richard A.; Morrison, Dirk; Daniel, Ben K.

2009-01-01

This research considers how professional participants in a non-formal self-directed learning environment (NFSDL) made use of self-directed learning activities in a blended face-to-face and on line learning professional development course. The learning environment for the study was a professional development seminar on teaching in higher education…

Students' Reflections on the Relationships between Safe Learning Environments, Learning Challenge and Positive Experiences of Learning in a Simulated GP Clinic

ERIC Educational Resources Information Center

Young, J. E.; Williamson, M. I.; Egan, T. G.

2016-01-01

Learning environments are a significant determinant of student behaviour, achievement and satisfaction. In this article we use students' reflective essays to identify key features of the learning environment that contributed to positive and transformative learning experiences. We explore the relationships between these features, the students'…

Personal Learning Environments in the Workplace: An Exploratory Study into the Key Business Decision Factors

ERIC Educational Resources Information Center

Chatterjee, Arunangsu; Law, Effie Lai-Chong; Mikroyannidis, Alexander; Owen, Glyn; Velasco, Karen

2013-01-01

Personal Learning Environments (PLEs) have emerged as a solution to the need of learners for open and easily customisable learning environments. PLEs essentially hand complete control over the learning process to the learner. However, this learning model is not fully compatible with learning in the workplace, which is influenced by certain…

Argumentative Knowledge Construction in Online Learning Environments in and across Different Cultures: A Collaboration Script Perspective

ERIC Educational Resources Information Center

Weinberger, A.; Clark, D. B.; Haekkinen, P.; Tamura, Y.; Fischer, F.

2007-01-01

In recent years, information and communication technology has established new opportunities to participate in online learning environments around the globe. These opportunities include the dissemination of specific online learning environments as well as opportunities for learners to connect to online learning environments in distant locations.…

Turkish High School Student's Perceptions of Learning Environment in Biology Classrooms and Their Attitudes toward Biology.

ERIC Educational Resources Information Center

Cakiroglu, Jale; Telli, Sibel; Cakiroglu, Erdinc

The purpose of this study was to examine Turkish high school students' perceptions of learning environment in biology classrooms and to investigate relationships between learning environment and students' attitudes toward biology. Secondly, the study aimed to investigate the differences in students' perceptions of learning environments in biology…

Growth hormone transgenesis does not influence territorial dominance or growth and survival of first-feeding Atlantic salmon Salmo salar in food-limited stream microcosms.

PubMed

Moreau, D T R; Fleming, I A; Fletcher, G L; Brown, J A

2011-03-01

This study explored the relative competitive ability and performance of first-feeding growth hormone (GH) transgenic and non-transgenic Atlantic salmon Salmo salar fry under low food conditions. Pair-wise dominance trials indicated a strong competitive advantage for residents of a contested foraging territory. Transgenic and non-transgenic individuals, however, were equally likely to be dominant. Similarly, in stream environments with limited food, the transgene did not influence the growth in mass or survival at high or low fry densities. Fry in low-density treatments, however, performed better than fry in high-density treatments. These results indicate that, under the environment examined, the growth performance of GH-transgenic and non-transgenic S. salar may be similar during first feeding, an intense period of selection in their life history. Similarities in competitive ability and growth performance with wild-type fish suggest that the capacity of transgenic S. salar to establish in natural streams may not be inhibited during early life history. © 2011 The Authors. Journal of Fish Biology © 2011 The Fisheries Society of the British Isles.

Does academic performance or personal growth share a stronger association with learning environment perception?

PubMed

Colbert-Getz, Jorie M; Tackett, Sean; Wright, Scott M; Shochet, Robert S

2016-08-28

This study was conducted to characterize the relative strength of associations of learning environment perception with academic performance and with personal growth. In 2012-2014 second and third year students at Johns Hopkins University School of Medicine completed a learning environment survey and personal growth scale. Hierarchical linear regression analysis was employed to determine if the proportion of variance in learning environment scores accounted for by personal growth was significantly larger than the proportion accounted for by academic performance (course/clerkship grades). The proportion of variance in learning environment scores accounted for by personal growth was larger than the proportion accounted for by academic performance in year 2 [R(2)Δ of 0.09, F(1,175) = 14.99,  p < .001] and year 3 [R(2)Δ of 0.28, F(1,169) = 76.80, p < .001]. Learning environment scores shared a small amount of variance with academic performance in years 2 and 3.  The amount of variance between learning environment scores and personal growth was small in year 2 and large in year 3. Since supportive learning environments are essential for medical education, future work must determine if enhancing personal growth prior to and during the clerkship year will increase learning environment perception.

Does academic performance or personal growth share a stronger association with learning environment perception?

PubMed Central

Tackett, Sean; Wright, Scott M.; Shochet, Robert S.

2016-01-01

Objectives This study was conducted to characterize the relative strength of associations of learning environment perception with academic performance and with personal growth. Methods In 2012-2014 second and third year students at Johns Hopkins University School of Medicine completed a learning environment survey and personal growth scale. Hierarchical linear regression analysis was employed to determine if the proportion of variance in learning environment scores accounted for by personal growth was significantly larger than the proportion accounted for by academic performance (course/clerkship grades). Results The proportion of variance in learning environment scores accounted for by personal growth was larger than the proportion accounted for by academic performance in year 2 [R2Δ of 0.09, F(1,175) = 14.99,  p < .001] and year 3 [R2Δ of 0.28, F(1,169) = 76.80, p < .001]. Learning environment scores shared a small amount of variance with academic performance in years 2 and 3.  The amount of variance between learning environment scores and personal growth was small in year 2 and large in year 3. Conclusions Since supportive learning environments are essential for medical education, future work must determine if enhancing personal growth prior to and during the clerkship year will increase learning environment perception. PMID:27570912

2. Historic American Buildings Survey Branan Sanders, Photographer March 1934 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey Branan Sanders, Photographer March 1934 FORT WYMBERLY- NORTH Also reproduced in 'Garden History of Georgia', page 19. - Wormsloe, Isle of Hope, Savannah Vicinity, Savannah, Chatham County, GA

75 FR 29205 - Changes in Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-25

... Business Review. Collins Avenue, Suite 250, Sunny Isles Beach, FL 33160. Osceola City of St. Cloud (09... Morrow (09-04- February 12, 2010; The Honorable Jim June 21, 2010 130045 4735P). Februrary 19, 2010...

4. Light tower and keeper's house ,view west, southeast and ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Light tower and keeper's house ,view west, southeast and northeast sides - Baker Island Light, Lightkeeper's House, Just east of Cranberry Isles, at entrance to Frenchman Bay, Bar Harbor, Hancock County, ME

1. Keeper's house and light tower, view northeast, northwest and ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Keeper's house and light tower, view northeast, northwest and southwest sides - Baker Island Light, Lightkeeper's House, Just east of Cranberry Isles, at entrance to Frenchman Bay, Bar Harbor, Hancock County, ME

77 FR 35860 - Safety Zone; Bay Swim V, Presque Isle Bay, Erie, PA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-15

... and the boating public. Discussion of Proposed Rule With the aforementioned hazards in mind, the... management systems practices) that are developed or adopted by voluntary consensus standards bodies. This...

Developing Learning Theory by Refining Conjectures Embodied in Educational Designs

ERIC Educational Resources Information Center

Sandoval, William A.

2004-01-01

Designed learning environments embody conjectures about learning and instruction, and the empirical study of learning environments allows such conjectures to be refined over time. The construct of embodied conjecture is introduced as a way to demonstrate the theoretical nature of learning environment design and to frame methodological issues in…

Virtual Learning Environment for Interactive Engagement with Advanced Quantum Mechanics

ERIC Educational Resources Information Center

Pedersen, Mads Kock; Skyum, Birk; Heck, Robert; Müller, Romain; Bason, Mark; Lieberoth, Andreas; Sherson, Jacob F.

2016-01-01

A virtual learning environment can engage university students in the learning process in ways that the traditional lectures and lab formats cannot. We present our virtual learning environment "StudentResearcher," which incorporates simulations, multiple-choice quizzes, video lectures, and gamification into a learning path for quantum…

Issues of Learning Games: From Virtual to Real

ERIC Educational Resources Information Center

Carron, Thibault; Pernelle, Philippe; Talbot, Stéphane

2013-01-01

Our research work deals with the development of new learning environments, and we are particularly interested in studying the different aspects linked to users' collaboration in these environments. We believe that Game-based Learning can significantly enhance learning. That is why we have developed learning environments grounded on graphical…

Agent-Based Learning Environments as a Research Tool for Investigating Teaching and Learning.

ERIC Educational Resources Information Center

Baylor, Amy L.

2002-01-01

Discusses intelligent learning environments for computer-based learning, such as agent-based learning environments, and their advantages over human-based instruction. Considers the effects of multiple agents; agents and research design; the use of Multiple Intelligent Mentors Instructing Collaboratively (MIMIC) for instructional design for…

Student-Centred Learning Environments: An Investigation into Student Teachers' Instructional Preferences and Approaches to Learning

ERIC Educational Resources Information Center

Baeten, Marlies; Dochy, Filip; Struyven, Katrien; Parmentier, Emmeline; Vanderbruggen, Anne

2016-01-01

The use of student-centred learning environments in education has increased. This study investigated student teachers' instructional preferences for these learning environments and how these preferences are related to their approaches to learning. Participants were professional Bachelor students in teacher education. Instructional preferences and…

Active Learning Environment with Lenses in Geometric Optics

ERIC Educational Resources Information Center

Tural, Güner

2015-01-01

Geometric optics is one of the difficult topics for students within physics discipline. Students learn better via student-centered active learning environments than the teacher-centered learning environments. So this study aimed to present a guide for middle school teachers to teach lenses in geometric optics via active learning environment…

Practical Applications and Experiences in K-20 Blended Learning Environments

ERIC Educational Resources Information Center

Kyei-Blankson, Lydia, Ed.; Ntuli, Esther, Ed.

2014-01-01

Learning environments continue to change considerably and is no longer confined to the face-to-face classroom setting. As learning options have evolved, educators must adopt a variety of pedagogical strategies and innovative technologies to enable learning. "Practical Applications and Experiences in K-20 Blended Learning Environments"…

Students' perception of the learning environment in a distributed medical programme

PubMed Central

Veerapen, Kiran; McAleer, Sean

2010-01-01

Background The learning environment of a medical school has a significant impact on students' achievements and learning outcomes. The importance of equitable learning environments across programme sites is implicit in distributed undergraduate medical programmes being developed and implemented. Purpose To study the learning environment and its equity across two classes and three geographically separate sites of a distributed medical programme at the University of British Columbia Medical School that commenced in 2004. Method The validated Dundee Ready Educational Environment Survey was sent to all students in their 2nd and 3rd year (classes graduating in 2009 and 2008) of the programme. The domains of the learning environment surveyed were: students' perceptions of learning, students' perceptions of teachers, students' academic self-perceptions, students' perceptions of the atmosphere, and students' social self-perceptions. Mean scores, frequency distribution of responses, and inter- and intrasite differences were calculated. Results The perception of the global learning environment at all sites was more positive than negative. It was characterised by a strongly positive perception of teachers. The work load and emphasis on factual learning were perceived negatively. Intersite differences within domains of the learning environment were more evident in the pioneer class (2008) of the programme. Intersite differences consistent across classes were largely related to on-site support for students. Conclusions Shared strengths and weaknesses in the learning environment at UBC sites were evident in areas that were managed by the parent institution, such as the attributes of shared faculty and curriculum. A greater divergence in the perception of the learning environment was found in domains dependent on local arrangements and social factors that are less amenable to central regulation. This study underlines the need for ongoing comparative evaluation of the learning environment at the distributed sites and interaction between leaders of these sites. PMID:20922033

The effects of different learning environments on students' motivation for learning and their achievement.

PubMed

Baeten, Marlies; Dochy, Filip; Struyven, Katrien

2013-09-01

Research in higher education on the effects of student-centred versus lecture-based learning environments generally does not take into account the psychological need support provided in these learning environments. From a self-determination theory perspective, need support is important to study because it has been associated with benefits such as autonomous motivation and achievement. The purpose of the study is to investigate the effects of different learning environments on students' motivation for learning and achievement, while taking into account the perceived need support. First-year student teachers (N= 1,098) studying a child development course completed questionnaires assessing motivation and perceived need support. In addition, a prior knowledge test and case-based assessment were administered. A quasi-experimental pre-test/post-test design was set up consisting of four learning environments: (1) lectures, (2) case-based learning (CBL), (3) alternation of lectures and CBL, and (4) gradual implementation with lectures making way for CBL. Autonomous motivation and achievement were higher in the gradually implemented CBL environment, compared to the CBL environment. Concerning achievement, two additional effects were found; students in the lecture-based learning environment scored higher than students in the CBL environment, and students in the gradually implemented CBL environment scored higher than students in the alternated learning environment. Additionally, perceived need support was positively related to autonomous motivation, and negatively to controlled motivation. The study shows the importance of gradually introducing students to CBL, in terms of their autonomous motivation and achievement. Moreover, the study emphasizes the importance of perceived need support for students' motivation. © 2012 The British Psychological Society.

Understanding teacher responses to constructivist learning environments: Challenges and resolutions

NASA Astrophysics Data System (ADS)

Rosenfeld, Melodie; Rosenfeld, Sherman

2006-05-01

The research literature is just beginning to uncover factors involved in sustaining constructivist learning environments, such as Project-Based Learning (PBL). Our case study investigates teacher responses to the challenges of constructivist environments, since teachers can play strong roles in supporting or undermining even the best constructivist environments or materials. We were invited to work as mediators with a middle-school science staff that was experiencing conflicts regarding two learning environments, PBL (which was the school's politically correc learning environment) and traditional. With mediated group workshops, teachers were sensitized to their own and colleagues' individual learning differences (ILDs), as measured by two styles inventories (the LSI - Kolb, 1976; and the LCI - Johnston & Dainton, 1997). Using these inventories, a learning-environment questionnaire, field notes, and delayed interviews a year later, we found that there was a relationship between teachers' preferred styles, epistemological beliefs, and their preferred teaching environment. Moreover, when the participating teachers, including early-adopters and nonvolunteers to PBL, became more sensitive to their colleagues' preferences, many staff conflicts were resolved and some mismatched teachers expressed more openness to PBL. We argue that having teachers understand their own ILDs and related responses to constructivist learning environments can contribute to resolving staff conflicts and sustaining such environments. We present a cognitive model and a strategy which illustrate this argument.

Use of Heuristics to Facilitate Scientific Discovery Learning in a Simulation Learning Environment in a Physics Domain

ERIC Educational Resources Information Center

Veermans, Koen; van Joolingen, Wouter; de Jong, Ton

2006-01-01

This article describes a study into the role of heuristic support in facilitating discovery learning through simulation-based learning. The study compares the use of two such learning environments in the physics domain of collisions. In one learning environment (implicit heuristics) heuristics are only used to provide the learner with guidance…

The Impacts of Network Centrality and Self-Regulation on an E-Learning Environment with the Support of Social Network Awareness

ERIC Educational Resources Information Center

Lin, Jian-Wei; Huang, Hsieh-Hong; Chuang, Yuh-Shy

2015-01-01

An e-learning environment that supports social network awareness (SNA) is a highly effective means of increasing peer interaction and assisting student learning by raising awareness of social and learning contexts of peers. Network centrality profoundly impacts student learning in an SNA-related e-learning environment. Additionally,…

Students' Conception of Learning Environment and Their Approach to Learning and Its Implication on Quality Education

ERIC Educational Resources Information Center

Belaineh, Matheas Shemelis

2017-01-01

Quality of education in higher institutions can be affected by different factors. It partly rests on the learning environment created by teachers and the learning approach students are employing during their learning. The main purpose of this study is to examine the learning environment at Mizan Tepi University from students' perspective and their…

Review of Opinions of Math Teachers Concerning the Learning Environment That They Design

ERIC Educational Resources Information Center

Aydin, Bünyamin; Yavuz, Ayse

2016-01-01

Design of appropriate learning environment has a significant importance in creation of aims of the math teaching. In the design of learning environments, teachers play a significant role. The aim of this study is determination of opinions of the math teachers concerning the learning environment that they design. In accordance with this aim, an…

An Effect of the Learning Environment Management System toward Student Quality of Thai Secondary School

ERIC Educational Resources Information Center

Wirussawa, Seatuch; Tesaputa, Kowat; Duangpaeng, Amporn

2016-01-01

This study aimed at 1) investigating the element of the learning environment management system in the secondary schools, 2) exploring the current states and problems of the system on the learning environment management in the secondary schools, 3) designing the learning environment management system for the secondary schools, and 4) identifying…

Authoring Adaptive 3D Virtual Learning Environments

ERIC Educational Resources Information Center

Ewais, Ahmed; De Troyer, Olga

2014-01-01

The use of 3D and Virtual Reality is gaining interest in the context of academic discussions on E-learning technologies. However, the use of 3D for learning environments also has drawbacks. One way to overcome these drawbacks is by having an adaptive learning environment, i.e., an environment that dynamically adapts to the learner and the…

Assessing the Quality of Learning Environments in Swedish Schools: Development and Analysis of a Theory-Based Instrument

ERIC Educational Resources Information Center

Westling Allodi, Mara

2007-01-01

The Goals, Attitudes and Values in School (GAVIS) questionnaire was developed on the basis of theoretical frameworks concerning learning environments, universal human values and studies of students' experience of learning environments. The theory hypothesises that learning environments can be described and structured in a circumplex model using…

Students' Perceptions of Computer-Based Learning Environments, Their Attitude towards Business Statistics, and Their Academic Achievement: Implications from a UK University

ERIC Educational Resources Information Center

Nguyen, ThuyUyen H.; Charity, Ian; Robson, Andrew

2016-01-01

This study investigates students' perceptions of computer-based learning environments, their attitude towards business statistics, and their academic achievement in higher education. Guided by learning environments concepts and attitudinal theory, a theoretical model was proposed with two instruments, one for measuring the learning environment and…

Blackboard as an Online Learning Environment: What Do Teacher Education Students and Staff Think?

ERIC Educational Resources Information Center

Heirdsfield, Ann; Walker, Susan; Tambyah, Mallihai; Beutel, Denise

2011-01-01

As online learning environments now have an established presence in higher education we need to ask the question: How effective are these environments for student learning? Online environments can provide a different type of learning experience than traditional face-to-face contexts (for on-campus students) or print-based materials (for distance…

Effects of the Physical Environment on Cognitive Load and Learning: Towards a New Model of Cognitive Load

ERIC Educational Resources Information Center

Choi, Hwan-Hee; van Merriënboer, Jeroen J. G.; Paas, Fred

2014-01-01

Although the theoretical framework of cognitive load theory has acknowledged a role for the learning environment, the specific characteristics of the physical learning environment that could affect cognitive load have never been considered, neither theoretically nor empirically. In this article, we argue that the physical learning environment, and…

Context Aware Ubiquitous Learning Environments for Peer-to-Peer Collaborative Learning

ERIC Educational Resources Information Center

Yang, Stephen J. H.

2006-01-01

A ubiquitous learning environment provides an interoperable, pervasive, and seamless learning architecture to connect, integrate, and share three major dimensions of learning resources: learning collaborators, learning contents, and learning services. Ubiquitous learning is characterized by providing intuitive ways for identifying right learning…

[The use of virtual learning environment in teaching basic and advanced life support].

PubMed

Cogo, Ana Luísa Petersen; Silveira, Denise Tolfo; Lírio, Aline de Morais; Severo, Carolina Lopes

2003-12-01

The present paper is the result of an experiment conducted as part of the Nursing: basic and advanced life support course, which was offered as a semi-online course using the virtual learning environment called Learning Space. The virtual learning environment optimizes classroom dynamics, since in the classroom setting, practical activities may be privileged; besides, learning is customized as students may access the environment whenever and wherever they wish.

Smile: Student Modification in Learning Environments. Establishing Congruence between Actual and Preferred Classroom Learning Environment.

ERIC Educational Resources Information Center

Yarrow, Allan; Millwater, Jan

1995-01-01

This study investigated whether classroom psychosocial environment, as perceived by student teachers, could be improved to their preferred level. Students completed the College and University Classroom Environment Inventory, discussed interventions, then completed it again. Significant deficiencies surfaced in the learning environment early in the…

Integrating Model-Driven and Data-Driven Techniques for Analyzing Learning Behaviors in Open-Ended Learning Environments

ERIC Educational Resources Information Center

Kinnebrew, John S.; Segedy, James R.; Biswas, Gautam

2017-01-01

Research in computer-based learning environments has long recognized the vital role of adaptivity in promoting effective, individualized learning among students. Adaptive scaffolding capabilities are particularly important in open-ended learning environments, which provide students with opportunities for solving authentic and complex problems, and…

A Comparison of Participation Patterns in Selected Formal, Non-Formal, and Informal Online Learning Environments

ERIC Educational Resources Information Center

Schwier, Richard A.; Seaton, J. X.

2013-01-01

Does learner participation vary depending on the learning context? Are there characteristic features of participation evident in formal, non-formal, and informal online learning environments? Six online learning environments were chosen as epitomes of formal, non-formal, and informal learning contexts and compared. Transcripts of online…

Student-Teachers' Approaches to Learning, Academic Performance and Teaching Efficacy

ERIC Educational Resources Information Center

Swee-Choo, Pauline Goh; Kung-Teck, Wong; Osman, Rosma

2012-01-01

Purpose: It is argued that the approaches to learning of students undergoing teacher training are likely to be related to their teaching and learning environment, especially as they move from a more regimented, structured learning environment in school to a tertiary learning environment that encourages more independent thinking and perhaps…

Visits to Cultural Learning Places in the Early Childhood

ERIC Educational Resources Information Center

Mudiappa, Michael; Kluczniok, Katharina

2015-01-01

Studies show the important role of the home learning environment in early childhood for later school success. This article focuses on a particular aspect of the home learning environment: visits to cultural learning places (e.g. museums) as a component of the quality of the home learning environment. Therefore the educational concept of…

Investigating Learning through Work: Learning Environment Scale & User Guide to the Provider. Support Document

ERIC Educational Resources Information Center

Hawke, Geof; Chappell, Clive

2008-01-01

This Support Document was produced by the authors based on their research for the report, "Investigating Learning through Work: The Development of the 'Provider Learning Environment Scale'" (ED503392). It provides readers with a complete copy of the "Provider Learning Environment Scale" (version 2.0); and an accompanying user…

Assessing and Monitoring Student Progress in an E-Learning Personnel Preparation Environment.

ERIC Educational Resources Information Center

Meyen, Edward L.; Aust, Ronald J.; Bui, Yvonne N.; Isaacson, Robert

2002-01-01

Discussion of e-learning in special education personnel preparation focuses on student assessment in e-learning environments. It includes a review of the literature, lessons learned by the authors from assessing student performance in e-learning environments, a literature perspective on electronic portfolios in monitoring student progress, and the…

A Context-Adaptive Teacher Training Model in a Ubiquitous Learning Environment

ERIC Educational Resources Information Center

Chen, Min; Chiang, Feng Kuang; Jiang, Ya Na; Yu, Sheng Quan

2017-01-01

In view of the discrepancies in teacher training and teaching practice, this paper put forward a context-adaptive teacher training model in a ubiquitous learning (u-learning) environment. The innovative model provides teachers of different subjects with adaptive and personalized learning content in a u-learning environment, implements intra- and…

Medical Student Perceptions of the Learning Environment in Medical School Change as Students Transition to Clinical Training in Undergraduate Medical School.

PubMed

Dunham, Lisette; Dekhtyar, Michael; Gruener, Gregory; CichoskiKelly, Eileen; Deitz, Jennifer; Elliott, Donna; Stuber, Margaret L; Skochelak, Susan E

2017-01-01

Phenomenon: The learning environment is the physical, social, and psychological context in which a student learns. A supportive learning environment contributes to student well-being and enhances student empathy, professionalism, and academic success, whereas an unsupportive learning environment may lead to burnout, exhaustion, and cynicism. Student perceptions of the medical school learning environment may change over time and be associated with students' year of training and may differ significantly depending on the student's gender or race/ethnicity. Understanding the changes in perceptions of the learning environment related to student characteristics and year of training could inform interventions that facilitate positive experiences in undergraduate medical education. The Medical School Learning Environment Survey (MSLES) was administered to 4,262 students who matriculated at one of 23 U.S. and Canadian medical schools in 2010 and 2011. Students completed the survey at the end of each year of medical school as part of a battery of surveys in the Learning Environment Study. A mixed-effects longitudinal model, t tests, Cohen's d effect size, and analysis of variance assessed the relationship between MSLES score, year of training, and demographic variables. After controlling for gender, race/ethnicity, and school, students reported worsening perceptions toward the medical school learning environment, with the worst perceptions in the 3rd year of medical school as students begin their clinical experiences, and some recovery in the 4th year after Match Day. The drop in MSLES scores associated with the transition to the clinical learning environment (-0.26 point drop in addition to yearly change, effect size = 0.52, p < .0001) is more than 3 times greater than the drop between the 1st and 2nd year (0.07 points, effect size = 0.14, p < .0001). The largest declines were from items related to work-life balance and informal student relationships. There was some, but not complete, recovery in perceptions of the medical school learning environment in the 4th year. Insights: Perceptions of the medical school learning environment worsen as students continue through medical school, with a stronger decline in perception scores as students' transition to the clinical learning environment. Students reported the greatest drop in finding time for outside activities and students helping one another in the 3rd year. Perceptions differed based on gender and race/ethnicity. Future studies should investigate the specific features of medical schools that contribute most significantly to student perceptions of the medical school learning environment, both positive and negative, to pinpoint potential interventions and improvements.

76 FR 4148 - Notice of Opportunity for Public Comment on Surplus Property Release at Brunswick-Golden Isles...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-24

... at the following address: Atlanta Airports District Office, Attn: Aimee A. McCormick, Program Manager.... FOR FURTHER INFORMATION CONTACT: Aimee McCormick, Program Manager, Atlanta Airports District Office...

The chorion ultrastructure of ova of Lophius spp.

PubMed

Colmenero, A I; Tuset, V M; Fortuño, J-M; Sánchez, P

2015-06-01

The chorion surface ultrastructure of unfertilized eggs of black anglerfish Lophius budegassa and white anglerfish Lophius piscatorius was examined by scanning electron microscopy. Species-specific differences were observed. © 2015 The Fisheries Society of the British Isles.

6. Light tower, detail of stairs leading from first landing ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Light tower, detail of stairs leading from first landing to cupola, looking east - Baker Island Light, Lightkeeper's House, Just east of Cranberry Isles, at entrance to Frenchman Bay, Bar Harbor, Hancock County, ME

5. Light tower and corner of keeper's house, view northeast, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Light tower and corner of keeper's house, view northeast, northwest and southwest sides - Baker Island Light, Lightkeeper's House, Just east of Cranberry Isles, at entrance to Frenchman Bay, Bar Harbor, Hancock County, ME

Management practices that concentrate visitor activities: Camping impact management at Isle Royale National Park, USA

USGS Publications Warehouse

Marion, J.L.; Farrell, T.A.

2002-01-01

This study assessed campsite conditions and the effectiveness of campsite impact management strategies at Isle Royale National Park, USA. Protocols for assessing indicators of vegetation and soil conditions were developed and applied to 156 campsites and 88 shelters within 36 backcountry campgrounds. The average site was 68 m2 and 83% of sites lost vegetation over areas less than 47 m2. Results reveal that management actions to spatially concentrate camping activities and reduce camping disturbance have been highly successful. Comparisons of disturbed area/overnight stay among other protected areas reinforces this assertion. These reductions in area of camping disturbance are attributed to a designated site camping policy, limitation on site numbers, construction of sites in sloping terrain, use of facilities, and an ongoing program of campsite maintenance. Such actions are most appropriate in higher use backcountry and wilderness settings.

Detonation Product EOS Studies: Using ISLS to Refine Cheetah

NASA Astrophysics Data System (ADS)

Zaug, J. M.; Howard, W. M.; Fried, L. E.; Hansen, D. W.

2002-07-01

Knowledge of an effective interatomic potential function underlies any effort to predict or rationalize the properties of solids and liquids. The experiments we undertake are directed towards determination of equilibrium and dynamic properties of simple fluids at densities sufficiently high that traditional computational methods and semi-empirical forms successful at ambient conditions may require reconsideration. In this paper we present high-pressure and temperature experimental sound speed data on a simple fluid, methanol. Impulsive Stimulated Light Scattering (ISLS) conducted on diamond-anvil cell (DAC) encapsulated samples offers an experimental approach to determine cross-pair potential interactions through equation of state determinations. In addition the kinetics of structural relaxation in fluids can be studied. We compare our experimental results with our thermochemical computational model Cheetah. Experimentally grounded computational models provide a good basis to confidently understand the chemical nature of reactions at extreme conditions.

Lap time simulation and design optimisation of a brushed DC electric motorcycle for the Isle of Man TT Zero Challenge

NASA Astrophysics Data System (ADS)

Dal Bianco, N.; Lot, R.; Matthys, K.

2018-01-01

This works regards the design of an electric motorcycle for the annual Isle of Man TT Zero Challenge. Optimal control theory was used to perform lap time simulation and design optimisation. A bespoked model was developed, featuring 3D road topology, vehicle dynamics and electric power train, composed of a lithium battery pack, brushed DC motors and motor controller. The model runs simulations over the entire ? or ? of the Snaefell Mountain Course. The work is validated using experimental data from the BX chassis of the Brunel Racing team, which ran during the 2009 to 2015 TT Zero races. Optimal control is used to improve drive train and power train configurations. Findings demonstrate computational efficiency, good lap time prediction and design optimisation potential, achieving a 2 minutes reduction of the reference lap time through changes in final drive gear ratio, battery pack size and motor configuration.

Latent volcanic heat and further unique aspects of early diagenetic stratiform copper mineralization in the White Pine-Presque Isle District, northern Michigan

NASA Astrophysics Data System (ADS)

Brown, Alex C.

2018-06-01

The curious occurrence of copper-rich early diagenetic sediment-hosted stratiform copper mineralization in the finest-grained facies of Nonesuch greybeds in northern Michigan has been previously attributed to the warming of cupriferous brines in the footwall Copper Harbor Conglomerate by latent volcanic heat from the subjacent Porcupine Volcanics shield volcano. That anomalous footwall warming is employed here to explain other unique aspects of the White Pine-Presque Isle mineralization: the abrupt downward sulfide zoning from disseminated pyrite to chalcocite across the top of the cupriferous zone; the absence of bornite and chalcopyrite in the cupriferous zone proper; and the essential absence of pseudomorphs after pyrite euhedra and framboidal aggregates within the cupriferous zone proper, as well as the relatively coarse-grained character of disseminated chalcocite in the cupriferous zone.

Bone structure of the temporo-mandibular joint in the individuals aged 18-25.

PubMed

Parafiniuk, M; Gutsch-Trepka, A; Trepka, S; Sycz, K; Wolski, S; Parafiniuk, W

1998-01-01

Osteohistometric studies were performed in 15 female and 15 male cadavers aged 18-25. Condyloid process and right and left acetabulum of the temporo-mandibular joint have been studied. Density has been investigated using monitor screen linked with microscope (magnification 80x). Density in the spongy part of the condyloid process was 26.67-26.77%; in the subchondrial layer--72.13-72.72%, and in the acetabular wall 75.03-75.91%. Microscopic structure of the bones of the temporo-mandibular joint revealed no differences when compared with images of compact and cancellous bone shown in the histology textbooks. Sex and the side of the body had no influence on microscopic image and proportional bone density. Isles of chondrocytes in the trabeculae of the spongy structure of the condyloid process were found in 4 cases and isles of the condensed bone resembling the compact pattern in 7 cases.

Plague, pox and the physician in Aberdeen, 1495-1516.

PubMed

Jillings, K

2010-03-01

This article discusses responses to disease in Aberdeen during a formative period in the provision of healthcare within the city. The foundation of King's College was followed, in 1497, by the establishment of the first royally endowed university Chair of Medicine in the British Isles, and its first incumbent, James Cumming, was employed by the local government as the first city doctor in 1503. His appointment had been preceded in 1497 by another legislative innovation in Aberdeen, when its council became the first civic body in the British Isles to implement regulations against the threat of the Great Pox (usually considered to be syphilis). It had subsequently to pass measures to prevent the spread of plague to the city, and these were typical of those already imposed elsewhere in Scotland and on the continent. Their apparent success in staving off plague lasted until 1514, when the city was struck by a severe outbreak which lasted two years.

The Use of Deep and Surface Learning Strategies among Students Learning English as a Foreign Language in an Internet Environment

ERIC Educational Resources Information Center

Aharony, Noa

2006-01-01

Background: The learning context is learning English in an Internet environment. The examination of this learning process was based on the Biggs and Moore's teaching-learning model (Biggs & Moore, 1993). Aim: The research aims to explore the use of the deep and surface strategies in an Internet environment among EFL students who come from…

Virtual Workshop Environment (VWE): A Taxonomy and Service Oriented Architecture (SOA) Framework for Modularized Virtual Learning Environments (VLE)--Applying the Learning Object Concept to the VLE

ERIC Educational Resources Information Center

Paulsson, Fredrik; Naeve, Ambjorn

2006-01-01

Based on existing Learning Object taxonomies, this article suggests an alternative Learning Object taxonomy, combined with a general Service Oriented Architecture (SOA) framework, aiming to transfer the modularized concept of Learning Objects to modularized Virtual Learning Environments. The taxonomy and SOA-framework exposes a need for a clearer…

Pre-registration student nurses perception of the hospital-learning environment during clinical placements.

PubMed

Midgley, Kirsten

2006-05-01

If we subscribe to the notion that nursing is an action profession, that nurses learn by doing [Neary, M., 2000. Responsive assessment: assessing student nurses' clinical competence. Nurse Education Today 21, 3-17], then the mastery of fundamental clinical skills must be a key component of courses leading to registration. The last two decades have seen widespread changes to nurse education but the clinical field remains an invaluable resource in preparing students for the reality of their professional role supporting the integration of theory and practice and linking the 'knowing what' with the 'knowing how'. The clinical-learning environment represents an essential element of nurse education that needs to be measurable and warrants further investigation. This exploratory cohort study (n = 67) examined pre-registration student nurses' perception of the hospital-learning environment during clinical placements together with the key characteristics of the students' preferred learning environment utilising an established tool, the clinical-learning environment inventory (CLEI) tool [Chan, D., 2001a. Development of an innovative tool to assess hospital-learning environments. Nurse Education Today 21, 624-631; Chan, D., 2001b. Combining qualitative and quantitative methods in assessing hospital-learning environments. International Journal of Nursing Studies 3, 447-459]. The results demonstrated that in comparison with the actual hospital environment, students would prefer an environment with higher levels of individualisation, innovation in teaching and learning strategies, student involvement, personalisation and task orientation.

Nursing students' perceptions of factors influencing their learning environment in a clinical skills laboratory: A qualitative study.

PubMed

Haraldseid, Cecilie; Friberg, Febe; Aase, Karina

2015-09-01

The mastery of clinical skills learning is required to become a trained nurse. Due to limited opportunities for clinical skills training in clinical practice, undergraduate training at clinical skills laboratories (CSLs) is an essential part of nursing education. In a sociocultural learning perspective learning is situated in an environment. Growing student cohorts, rapid introduction of technology-based teaching methods and a shift from a teaching- to a learning-centered education all influence the environment of the students. These changes also affect CSLs and therefore compel nursing faculties to adapt to the changing learning environment. This study aimed to explore students' perceptions of their learning environment in a clinical skills laboratory, and to increase the knowledge base for improving CSL learning conditions identifying the most important environmental factors according to the students. An exploratory qualitative methodology was used. Nineteen second-year students enrolled in an undergraduate nursing program in Norway participated in the study. They took the same clinical skills course. Eight were part-time students (group A) and 11 were full-time students (group B). Focus group interviews and content analysis were conducted to capture the students' perception of the CSL learning environment. The study documents students' experience of the physical (facilities, material equipment, learning tools, standard procedures), psychosocial (expectations, feedback, relations) and organizational (faculty resources, course structure) factors that affect the CSL learning environment. Creating an authentic environment, facilitating motivation, and providing resources for multiple methods and repetitions within clinical skills training are all important for improving CSL learning environments from the student perspective. Copyright © 2015 Elsevier Ltd. All rights reserved.

Validation of the Clinical Learning Environment Inventory.

PubMed

Chan, Dominic S

2003-08-01

One hundred eight preregistration nursing students took part in this survey study, which assessed their perceptions of the clinical learning environment. Statistical data based on the sample confirmed the reliability and validity of the Clinical Learning Environment Inventory (CLEI), which was developed using the concept of classroom learning environment studies. The study also found that there were significant differences between students' actual and preferred perceptions of the clinical learning environments. In terms of the CLEI scales, students preferred a more positive and favorable clinical environment than they perceived as being actually present. The achievement of certain outcomes of clinical field placements might be enhanced by attempting to change the actual clinical environment in ways that make it more congruent with that preferred by the students.

Nursing students' perceptions of learning in practice environments: a review.

PubMed

Henderson, Amanda; Cooke, Marie; Creedy, Debra K; Walker, Rachel

2012-04-01

Effective clinical learning requires integration of nursing students into ward activities, staff engagement to address individual student learning needs, and innovative teaching approaches. Assessing characteristics of practice environments can provide useful insights for development. This study identified predominant features of clinical learning environments from nursing students' perspectives across studies using the same measure in different countries over the last decade. Six studies, from three different countries, using the Clinical Leaning Environment Inventory (CLEI) were reviewed. Studies explored consistent trends about learning environment. Students rated sense of task accomplishment high. Affiliation also rated highly though was influenced by models of care. Feedback measuring whether students' individual needs and views were accommodated consistently rated lower. Across different countries students report similar perceptions about learning environments. Clinical learning environments are most effective in promoting safe practice and are inclusive of student learners, but not readily open to innovation and challenges to routine practices. Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.

Influences of Formal Learning, Personal Learning Orientation, and Supportive Learning Environment on Informal Learning

ERIC Educational Resources Information Center

Choi, Woojae; Jacobs, Ronald L.

2011-01-01

While workplace learning includes formal and informal learning, the relationship between the two has been overlooked, because they have been viewed as separate entities. This study investigated the effects of formal learning, personal learning orientation, and supportive learning environment on informal learning among 203 middle managers in Korean…

Effects of Presence, Copresence, and Flow on Learning Outcomes in 3D Learning Spaces

ERIC Educational Resources Information Center

Hassell, Martin D.; Goyal, Sandeep; Limayem, Moez; Boughzala, Imed

2012-01-01

The level of satisfaction and effectiveness of 3D virtual learning environments were examined. Additionally, 3D virtual learning environments were compared with face-to-face learning environments. Students that experienced higher levels of flow and presence also experienced more satisfaction but not necessarily more effectiveness with 3D virtual…

Student Experiences on Interaction in an Online Learning Environment as Part of a Blended Learning Implementation: What Is Essential?

ERIC Educational Resources Information Center

Salmi, Laura

2013-01-01

Interaction and community building are essential elements of a well functioning online learning environment, especially in learning environments based on investigative learning with a strong emphasis on teamwork. In this paper, practical solutions covering quality criteria for interaction in online education are presented for a simple…

Investigating Learners' Attitudes toward Virtual Reality Learning Environments: Based on a Constructivist Approach

ERIC Educational Resources Information Center

Huang, Hsiu-Mei; Rauch, Ulrich; Liaw, Shu-Sheng

2010-01-01

The use of animation and multimedia for learning is now further extended by the provision of entire Virtual Reality Learning Environments (VRLE). This highlights a shift in Web-based learning from a conventional multimedia to a more immersive, interactive, intuitive and exciting VR learning environment. VRLEs simulate the real world through the…

Factors of Learner-Instructor Interaction Which Predict Perceived Learning Outcomes in Online Learning Environment

ERIC Educational Resources Information Center

Kang, M.; Im, T.

2013-01-01

Interaction in the online learning environment has been regarded as one of the most critical elements that affect learning outcomes. This study examined what factors in learner-instructor interaction can predict the learner's outcomes in the online learning environment. Learners in K Online University participated by answering the survey, and data…

Self-Regulated Learning in Technology Enhanced Learning Environments: An Investigation with University Students

ERIC Educational Resources Information Center

Lenne, Dominique; Abel, Marie-Helene; Trigano, Philippe; Leblanc, Adeline

2008-01-01

In Technology Enhanced Learning Environments, self-regulated learning (SRL) partly relies on the features of the technological tools. The authors present two environments they designed in order to facilitate SRL: the first one (e-Dalgo) is a website dedicated to the learning of algorithms and computer programming. It is structured as a classical…

Using Student-Centred Learning Environments to Stimulate Deep Approaches to Learning: Factors Encouraging or Discouraging Their Effectiveness

ERIC Educational Resources Information Center

Baeten, Marlies; Kyndt, Eva; Struyven, Katrien; Dochy, Filip

2010-01-01

This review outlines encouraging and discouraging factors in stimulating the adoption of deep approaches to learning in student-centred learning environments. Both encouraging and discouraging factors can be situated in the context of the learning environment, in students' perceptions of that context and in characteristics of the students…

Perceived Satisfaction, Perceived Usefulness and Interactive Learning Environments as Predictors to Self-Regulation in e-Learning Environments

ERIC Educational Resources Information Center

Liaw, Shu-Sheng; Huang, Hsiu-Mei

2013-01-01

The research purpose is to investigate learner self-regulation in e-learning environments. In order to better understand learner attitudes toward e-learning, 196 university students answer a questionnaire survey after use an e-learning system few months. The statistical results showed that perceived satisfaction, perceived usefulness, and…

Learning in a Changing Environment

ERIC Educational Resources Information Center

Speekenbrink, Maarten; Shanks, David R.

2010-01-01

Multiple cue probability learning studies have typically focused on stationary environments. We present 3 experiments investigating learning in changing environments. A fine-grained analysis of the learning dynamics shows that participants were responsive to both abrupt and gradual changes in cue-outcome relations. We found no evidence that…

Student-Teacher Interaction in Online Learning Environments

ERIC Educational Resources Information Center

Wright, Robert D., Ed.

2015-01-01

As face-to-face interaction between student and instructor is not present in online learning environments, it is increasingly important to understand how to establish and maintain social presence in online learning. "Student-Teacher Interaction in Online Learning Environments" provides successful strategies and procedures for developing…

Preferred-Actual Learning Environment "Spaces" and Earth Science Outcomes in Taiwan

ERIC Educational Resources Information Center

Chang, Chun-Yen; Hsiao, Chien-Hua; Barufaldi, James P.

2006-01-01

This study examines the possibilities of differential impacts on students' earth science learning outcomes between different preferred-actual learning environment spaces by using a newly developed ESCLEI (Earth Science Classroom Learning Environment Instrument). The instrument emphasizes three simultaneously important classroom components:…

Causal Model Progressions as a Foundation for Intelligent Learning Environments.

DTIC Science & Technology

1987-11-01

Foundation for Intelligent Learning Environments 3Barbara Y. White and John R. Frederiksen ~DTIC Novemr1987 ELECTE November1987 JUNO 9 88 Approved I )’I...Learning Environments 12. PERSONAL AUTHOR(S? Barbara Y. White and John R. Frederiksen 13a. TYPE OF REPORT 13b TIME COVERED 14. DATE OF REPORT (Year...architecture of a new type of learning environment that incorporates features of microworlds and of intelligent tutorng systems. The environment is based on

Determination and Quantification of metals in the shells of Crassostrea virginica after the Deepwater Horizon oil spill utilizing Atomic Absorption Spectrometry.

NASA Astrophysics Data System (ADS)

Roopnarine, D.; Patel, S.; Roopnarine, P.; Giarikos, D.; Anderson, L. C.

2017-12-01

The Deepwater Horizon (DWH) oil rig explosion on April 20, 2010 resulted in the release of 685,000 tons of crude oil into the Gulf of Mexico (GOM) over a period of three months. There were obvious immediate effects, but the long-term ramifications are still being studied. The primary constituent of crude oil is hydrocarbons with other organic compounds containing nitrogen, oxygen and sulfur. There are also a number of trace metals with the most abundant frequently being iron, nickel, copper and vanadium. These do not degrade like organic materials. However, the exact composition varies among the production sites. The oil from the DWH rig was classified as light crude which is moderately volatile. Natural oil seeps occur in the environment, but the DWH spill represented an acute impact. Trace amounts of heavy metals are a normal part of the composition of marine organisms, but can be toxic in high concentrations. Bivalved molluscs bioaccumulate heavy metals in their tissues and shells, and are therefore often useful as monitors of environmental pollution. We thus used the Eastern oyster Crassostrea virginica to determine the impact of the spill by measuring the concentrations of metals in the shells utilizing flame emission atomic absorption spectrometry. We focused on the hypothesis that DWH spill exposure resulted in an increase in metal uptake into the shells. Specimens spanned the years 2010 to 2014 and ranged from Grand Isle, LA to Apalachicola Bay, Fl. Vanadium had the greatest concentration in the shells, and along with copper, cadmium, zinc and iron displayed an upward trend of increase from 2010 to 2013, with a decline in 2014. However there was unexpected variability, as the specimens from Apalachicola Bay, Fl had higher levels of vanadium when compared to those from Grand Isle, LA. Ongoing work includes an increase of sample sizes from the same geographic localities and time period.

The use of deep and surface learning strategies among students learning English as a foreign language in an Internet environment.

PubMed

Aharony, Noa

2006-12-01

The learning context is learning English in an Internet environment. The examination of this learning process was based on the Biggs and Moore's teaching-learning model (Biggs & Moore, 1993). The research aims to explore the use of the deep and surface strategies in an Internet environment among EFL students who come from different socio-economic backgrounds. The results of the research may add an additional level to the understanding of students' functioning in the Internet environment. One hundred fourty-eight Israeli junior and high school students participated in this research. The methodology was based on special computer software: Screen Cam, which recorded the students' learning process. In addition, expert judges completed a questionnaire which examined and categorized the students' learning strategies. The research findings show a clear preference of participants from all socio-economic backgrounds towards the surface learning strategy. The findings also showed that students from the medium to high socio-economic background used both learning strategies more frequently than low socio-economic students. The results reflect the habits that students acquire during their adjustment process throughout their education careers. A brief encounter with the Internet learning environment apparently cannot change norms or habits, which were acquired in the non-Internet learning environment.

Trends in winter circulation over the British Isles and central Europe in twenty-first century projections by 25 CMIP5 GCMs

NASA Astrophysics Data System (ADS)

Stryhal, Jan; Huth, Radan

2018-03-01

Winter midlatitude atmospheric circulation has been extensively studied for its tight link to surface weather, and automated circulation classifications have often been used to this end. Here, eight such classifications are applied to daily sea level pressure patterns simulated by an ensemble of CMIP5 GCMs twenty-first century projections for the British Isles and central Europe in order to robustly estimate future changes in frequency, persistence, and strength of synoptic-scale circulation there. All methods are able to identify present-day biases of models reported before, such as an overestimated occurrence of zonal flow and underestimation of anticyclonic conditions and easterly advection, although the strength of these biases varies among the methods. In future, models show that the zonal flow will become more frequent while the strength of the mean flow is not projected to change. Over the British Isles, the models that better simulate the latitude of zonal flow over the historical period indicate a slight equatorward shift of westerlies in their projections, while the poleward expansion of circulation—expected in future at global scale—is apparent in those models that have large errors. Over central Europe, some classifications indicate an increase in persistence and especially in frequency of anticyclonic types, which is, however, shown to be rather an artifact of some methods than a real feature. On the other hand, the easterly flow is robustly projected to become markedly weaker in central Europe, which we hypothesize might be an important factor contributing to the projected decrease of cold extremes there.

Fast Algorithms for Designing Unimodular Waveform(s) With Good Correlation Properties

NASA Astrophysics Data System (ADS)

Li, Yongzhe; Vorobyov, Sergiy A.

2018-03-01

In this paper, we develop new fast and efficient algorithms for designing single/multiple unimodular waveforms/codes with good auto- and cross-correlation or weighted correlation properties, which are highly desired in radar and communication systems. The waveform design is based on the minimization of the integrated sidelobe level (ISL) and weighted ISL (WISL) of waveforms. As the corresponding optimization problems can quickly grow to large scale with increasing the code length and number of waveforms, the main issue turns to be the development of fast large-scale optimization techniques. The difficulty is also that the corresponding optimization problems are non-convex, but the required accuracy is high. Therefore, we formulate the ISL and WISL minimization problems as non-convex quartic optimization problems in frequency domain, and then simplify them into quadratic problems by utilizing the majorization-minimization technique, which is one of the basic techniques for addressing large-scale and/or non-convex optimization problems. While designing our fast algorithms, we find out and use inherent algebraic structures in the objective functions to rewrite them into quartic forms, and in the case of WISL minimization, to derive additionally an alternative quartic form which allows to apply the quartic-quadratic transformation. Our algorithms are applicable to large-scale unimodular waveform design problems as they are proved to have lower or comparable computational burden (analyzed theoretically) and faster convergence speed (confirmed by comprehensive simulations) than the state-of-the-art algorithms. In addition, the waveforms designed by our algorithms demonstrate better correlation properties compared to their counterparts.

Designing new collaborative learning spaces in clinical environments: experiences from a children's hospital in Australia.

PubMed

Bines, Julie E; Jamieson, Peter

2013-09-01

Hospitals are complex places that provide a rich learning environment for students, staff, patients and their families, professional groups and the community. The "new" Royal Children's Hospital opened in late 2011. Its mission is focused on improving health and well-being of children and adolescents through leadership in healthcare, research and education. Addressing the need to create "responsive learning environments" aligned with the shift to student-centred pedagogy, two distinct learning environments were developed within the new Royal Children's Hospital; (i) a dedicated education precinct providing a suite of physical environments to promote a more active, collaborative and social learning experience for education and training programs conducted on the Royal Children's Hospital campus and (ii) a suite of learning spaces embedded within clinical areas so that learning becomes an integral part of the daily activities of this busy Hospital environment. The aim of this article is to present the overarching educational principles that lead the design of these learning spaces and describe the opportunities and obstacles encountered in the development of collaborative learning spaces within a large hospital development.

Perceptions of Pre-Service Teachers on the Design of a Learning Environment Based on the Seven Principles of Good Practice

ERIC Educational Resources Information Center

Al-Furaih, Suad Abdul Aziz

2017-01-01

This study explored the perceptions of 88 pre-service teachers on the design of a learning environment using the Seven Principles of Good Practice and its effect on participants' abilities to create their Cloud Learning Environment (CLE). In designing the learning environment, a conceptual model under the name 7 Principles and Integrated Learning…

A Case Study of the Experiences of Instructors and Students in a Virtual Learning Environment (VLE) with Different Cultural Backgrounds

ERIC Educational Resources Information Center

Lim, Keol; Kim, Mi Hwa

2015-01-01

The use of virtual learning environments (VLEs) has become more common and educators recognized the potential of VLEs as educational environments. The learning community in VLEs can be a mixture of people from all over the world with different cultural backgrounds. However, despite many studies about the use of virtual environments for learning,…

Virtual Representations in 3D Learning Environments

ERIC Educational Resources Information Center

Shonfeld, Miri; Kritz, Miki

2013-01-01

This research explores the extent to which virtual worlds can serve as online collaborative learning environments for students by increasing social presence and engagement. 3D environments enable learning, which simulates face-to-face encounters while retaining the advantages of online learning. Students in Education departments created avatars…

33 CFR 80.707 - Cape Romain, SC to Sullivans Island, SC.

Code of Federal Regulations, 2013 CFR

2013-07-01

... the easternmost extremity of Capers Island. (d) A line formed by the overhead power cable from Capers Island to Dewees Island. (e) A line formed by the overhead power cable from Dewees Island to Isle of...

33 CFR 80.707 - Cape Romain, SC to Sullivans Island, SC.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the easternmost extremity of Capers Island. (d) A line formed by the overhead power cable from Capers Island to Dewees Island. (e) A line formed by the overhead power cable from Dewees Island to Isle of...

Cold-front driven storm erosion and overwash in the central part of the Isles Dernieres, a Louisiana barrier-island arc

USGS Publications Warehouse

Dingler, J.R.; Reiss, T.E.

1990-01-01

Tropical and extratropical storms produce significant erosion on the barrier islands of Louisiana. Over the past 100 years, such storms have produced at least 2 km of northward beach-face retreat and the loss of 63% of the surface area of the Isles Dernieres, a low-lying barrier-island arc along the central Louisiana coast. Elevations on the islands within the arc are typically less than 2 m above mean sea level. The islands typically have a washover-flat topography with occasional, poorly developed, dune-terrace topography consisting of low-lying and broken dunes. The central part of the arc consists of salt-marsh deposits overlain by washover sands along the Gulf of Mexico shoreline. Sand thicknesses range from zero behind the beach, to less than 2 m under the berm crest, and back to zero in the first nearshore trough. The sand veneer is sufficiently thin that storms can strip all the sand from the beach face, exposing the underlying marsh deposits. The geomorphic changes produced by cold fronts, a type of extratropical storm that commonly affect the Isles Dernieres between late fall and early spring are described. Between August 1986 and September 1987, repeated surveys along eleven shore-normal transects that covered 400 m of shoreline revealed the timing and extent of cold-front-produced beach change along a typical section of the central Isles Dernieres. During the study period, the beach face retreated approximately 20 m during the cold-front season but did not rebuild during the subsequent summer. Because the volume of sand deposited on the backshore (5600 m3) was less than the volume of material lost from the beach face (19,200 m3), approximately 13,600 m3 of material disappeared. Assuming that underlying marsh deposits decrease in volume in direct proportion to the amount of beach-face retreat, an estimate of the mud loss during the study period is 14,000 m3. Thus, the decrease in volume along the profiles can be accounted for without removing any sand from the area, suggesting that a major effect of cold fronts is first to strip the sand from the beach face and then to erode the underlying marsh deposits. After being eroded, the mud is lost from the islands because currents transport it away from the islands. ?? 1990.

Implementation of preventive strength training in residential geriatric care: a multi-centre study protocol with one year of interventions on multiple levels.

PubMed

Brach, Michael; Nieder, Frank; Nieder, Ulrike; Mechling, Heinz

2009-11-24

There is scientific evidence that preventive physical exercise is effective even in high age. In contrast, there are few opportunities of preventive exercise for highly aged people endangered by or actually in need of care. For example, they would not be able to easily go to training facilities; standard exercises may be too intensive and therefore be harmful to them; orientation disorders like dementia would exacerbate individuals and groups in following instructions and keeping exercises going. In order to develop appropriate interventions, these and other issues were assigned to different levels: the individual-social level (ISL), the organisational-institutional level (OIL) and the political-cultural level (PCL). Consequently, this conceptional framework was utilised for development, implementation and evaluation of a new strength and balance exercise programme for old people endangered by or actually in need of daily care. The present paper contains the development of this programme labeled "fit for 100", and a study protocol of an interventional single-arm multi-centre trial. The intervention consisted of (a) two group training sessions every week over one year, mainly resistance exercises, accompanied by sensorimotor and communicative group exercises and games (ISL), (b) a sustainable implementation concept, starting new groups by instructors belonging to the project, followed by training and supervision of local staff, who stepwise take over the group (OIL), (c) informing and convincing activities in professional, administrative and governmental contexts, public relation activities, and establishing an advisory council with renowned experts and public figures (PCL). Participating institutions of geriatric care were selected through several steps of quality criteria assessment. Primary outcome measures were continuous documentation of individual participation (ISL), number of groups continued without external financial support (at the end of the project, and after one year) (OIL). Secondary outcome was measured by sensorimotor tests and care-related assessments in the beginning and every 16 weeks (ISL), by qualitative outcome descriptions 12 months after group implementation (OIL) and by analysis of media response and structured interviews with stakeholders, also after 12 months (PCL). Exemplarily, preventive exercise has been established for a neglected target population. The multi-level approach used here seems to be helpful to overcome institutional and individual (attitude) barriers. Current Controlled Trials ISRCTN55213782.

Optimizing T-Learning Course Scheduling Based on Genetic Algorithm in Benefit-Oriented Data Broadcast Environments

ERIC Educational Resources Information Center

Huang, Yong-Ming; Chen, Chao-Chun; Wang, Ding-Chau

2012-01-01

Ubiquitous learning receives much attention in these few years due to its wide spectrum of applications, such as the T-learning application. The learner can use mobile devices to watch the digital TV based course content, and thus, the T-learning provides the ubiquitous learning environment. However, in real-world data broadcast environments, the…

Analysis of Means for Building Context-Aware Recommendation System for Mobile Learning

ERIC Educational Resources Information Center

Shcherbachenko, Larysa; Nowakowski, Samuel

2017-01-01

One of the rapidly developing tools for online learning is learning through a mobile environment. Therefore, developing and improving mobile learning environments is an active topic now. One of the ways to adapt the learning environment to the user's needs is to use his context. Context of the user consists of the current context in online…

Design Patterns for Learning and Assessment: Facilitating the Introduction of a Complex Simulation-Based Learning Environment into a Community of Instructors

ERIC Educational Resources Information Center

Frezzo, Dennis C.; Behrens, John T.; Mislevy, Robert J.

2010-01-01

Simulation environments make it possible for science and engineering students to learn to interact with complex systems. Putting these capabilities to effective use for learning, and assessing learning, requires more than a simulation environment alone. It requires a conceptual framework for the knowledge, skills, and ways of thinking that are…

Sustaining Teacher Control in a Blog-Based Personal Learning Environment

ERIC Educational Resources Information Center

Tomberg, Vladimir; Laanpere, Mart; Ley, Tobias; Normak, Peeter

2013-01-01

Various tools and services based on Web 2.0 (mainly blogs, wikis, social networking tools) are increasingly used in formal education to create personal learning environments, providing self-directed learners with more freedom, choice, and control over their learning. In such distributed and personalized learning environments, the traditional role…

Supporting the Transition of Learning Disabled Students to the Postsecondary Environment

ERIC Educational Resources Information Center

Gray, Patricia Jean

2012-01-01

Students with learning disabilities present a diverse spectrum of learning needs; research suggest they may have difficulty making the transition to the postsecondary environment. Learning disabled students at the subject high school were not successfully making the transition from the secondary to the postsecondary environment. This study was…

Utilizing Virtual and Personal Learning Environments for Optimal Learning

ERIC Educational Resources Information Center

Terry, Krista, Ed.; Cheney, Amy, Ed.

2016-01-01

The integration of emerging technologies in higher education presents a new set of challenges and opportunities for educators. With a growing need for customized lesson plans in online education, educators are rethinking the design and development of their learning environments. "Utilizing Virtual and Personal Learning Environments for…

Flipped Education: Transitioning to the Homeschool Environment

ERIC Educational Resources Information Center

Alamry, Adel; karaali, Abeer

2016-01-01

This paper seeks to introduce flipped learning as a viable learning method that can be used in the homeschool environment. Flipped learning can become a valuable aspect of homeschooling when the learning environment is conducive to the application of self-taught knowledge. In fact, the sessions evidently act as clarification bridges and…

Visualising Learning Design in LAMS: A Historical View

ERIC Educational Resources Information Center

Dalziel, James

2011-01-01

The Learning Activity Management System (LAMS) provides a web-based environment for the creation, sharing, running and monitoring of Learning Designs. A central feature of LAMS is the visual authoring environment, where educators use a drag-and-drop environment to create sequences of learning activities. The visualisation is based on boxes…

Determination of Science Teachers' Opinions about Outdoor Education

ERIC Educational Resources Information Center

Kubat, Ulas

2017-01-01

The aim of this research is to discover what science teachers' opinions about outdoor education learning environments are. Outdoor education learning environments contribute to problem-solving, critical and creative thinking skills of students. For this reason, outdoor education learning environments are very important for students to learn by…

Offering a Framework for Value Co-Creation in Virtual Academic Learning Environments

ERIC Educational Resources Information Center

Ranjbarfard, Mina; Heidari Sureshjani, Mahboobeh

2018-01-01

Purpose: This research aims to convert the traditional teacher-student models, in which teachers determine the learning resources, into a flexible structure and an active learning environment so that students can participate in the educational processes and value co-creation in virtual academic learning environments (VALEs).…

Constructivist Learning Environment among Palestinian Science Students

ERIC Educational Resources Information Center

Zeidan, Afif

2015-01-01

The purpose of this study was to investigate the constructivist learning environment among Palestinian science students. The study also aimed to investigate the effects of gender and learning level of these students on their perceptions of the constructivist learning environment. Data were collected from 125 male and 101 female students from the…

Disrupting a Learning Environment for Promotion of Geometry Teaching

ERIC Educational Resources Information Center

Jojo, Zingiswa

2017-01-01

Creating a classroom learning environment that is suitably designed for promotion of learners' performance in geometry, a branch of mathematics that addresses spatial sense and geometric reasoning, is a daunting task. This article focuses on how grade 8 teachers' action learning changed the learning environment for the promotion of geometry…

Criteria, Strategies and Research Issues of Context-Aware Ubiquitous Learning

ERIC Educational Resources Information Center

Hwang, Gwo-Jen; Tsai, Chin-Chung; Yang, Stephen J. H.

2008-01-01

Recent progress in wireless and sensor technologies has lead to a new development of learning environments, called context-aware ubiquitous learning environment, which is able to sense the situation of learners and provide adaptive supports. Many researchers have been investigating the development of such new learning environments; nevertheless,…

Kitchen Science Investigators: Promoting Identity Development as Scientific Reasoners and Thinkers

ERIC Educational Resources Information Center

Clegg, Tamara Lynnette

2010-01-01

My research centers upon designing transformative learning environments and supporting technologies. Kitchen Science Investigators (KSI) is an out-of-school transformative learning environment we designed to help young people learn science through cooking. My dissertation considers the question, "How can we design a learning environment in which…

Improving Collaborative Learning by Supporting Casual Encounters in Distance Learning.

ERIC Educational Resources Information Center

Contreras, Juan; Llamas, Rafael; Vizcaino, Aurora; Vavela, Jesus

Casual encounters in a learning environment are very useful in reinforcing previous knowledge and acquiring new knowledge. Such encounters are very common in traditional learning environments and can be used successfully in social environments in which students can discover and construct knowledge through a process of dialogue, negotiation, or…

Citizen Science as a REAL Environment for Authentic Scientific Inquiry

ERIC Educational Resources Information Center

Meyer, Nathan J.; Scott, Siri; Strauss, Andrea Lorek; Nippolt, Pamela L.; Oberhauser, Karen S.; Blair, Robert B.

2014-01-01

Citizen science projects can serve as constructivist learning environments for programming focused on science, technology, engineering, and math (STEM) for youth. Attributes of "rich environments for active learning" (REALs) provide a framework for design of Extension STEM learning environments. Guiding principles and design strategies…

Nursing Students' Qualitative Experiences in the Medical-Surgical Clinical Learning Environment: A Cross-Cultural Integrative Review.

PubMed

Hooven, Katie

2015-08-01

The nature of the clinical learning environment has a huge impact on student learning. For instance, research has supported the idea that a positive learning environment increases student learning. Therefore, the ability to gain information from the student perspective about the learning environment is essential to nursing education. This article reviews qualitative research on nursing students' experiences of the clinical learning environment. The significance of the issue, the purpose of the integrative review, the methods used in the literature search, and the results of the review are presented. Seventeen studies from 12 countries are identified for review, and six common themes are discussed. An exhaustive literature review revealed that among the 17 articles evaluated, six themes were common. The findings indicate the need to continue quality improvement to advance clinical education. Copyright 2015, SLACK Incorporated.

The Relationship among Self-Regulated Learning, Procrastination, and Learning Behaviors in Blended Learning Environment

ERIC Educational Resources Information Center

Yamada, Masanori; Goda, Yoshiko; Matsuda, Takeshi; Kato, Hiroshi; Miyagawa, Hiroyuki

2015-01-01

This research aims to investigate the relationship among the awareness of self-regulated learning (SRL), procrastination, and learning behaviors in blended learning environment. One hundred seventy nine freshmen participated in this research, conducted in the blended learning style class using learning management system. Data collection was…

Behavioral Feature Extraction to Determine Learning Styles in e-Learning Environments

ERIC Educational Resources Information Center

Fatahi, Somayeh; Moradi, Hadi; Farmad, Elaheh

2015-01-01

Learning Style (LS) is an important parameter in the learning process. Therefore, learning styles should be considered in the design, development, and implementation of e-learning environments. Consequently, an important capability of an e-learning system could be the automatic determination of a student's learning style. In this paper, a set of…

Effects of Collaborative Learning Styles on Performance of Students in a Ubiquitous Collaborative Mobile Learning Environment

ERIC Educational Resources Information Center

Fakomogbon, Michael Ayodele; Bolaji, Hameed Olalekan

2017-01-01

Collaborative learning is an approach employed by instructors to facilitate learning and improve learner's performance. Mobile learning can accommodate a variety of learning approaches. This study, therefore, investigated the effects of collaborative learning styles on performance of students in a mobile learning environment. The specific purposes…

Equitable Learning Outcomes: Supporting Economically and Culturally Disadvantaged Students in "Formative Learning Environments"

ERIC Educational Resources Information Center

Clark, Ian

2014-01-01

The central and distinguishing thesis of social and cultural perspectives on outcome equity is that public school classrooms are culturally biased environments. Such environments disaffect children who arrive at school from the economic or cultural margin. The "formative learning environment" (FoLE) establishes and sustains legitimate…

Characteristics of an Innovative Learning Environment According to Students' Perceptions: Actual versus Preferred

ERIC Educational Resources Information Center

Magen-Nagar, Noga; Steinberger, Pnina

2017-01-01

An innovative learning environment is the current outcome of the constructivist approach, the essence of which is co-construction of knowledge in an Information and Communication Technology (ICT) environment. We examined how Israeli students perceived 10 characteristics of their classroom learning environment--student cohesiveness, teacher…

Conducting and Supporting a Goal-Based Scenario Learning Environment.

ERIC Educational Resources Information Center

Montgomery, Joel; And Others

1994-01-01

Discussion of goal-based scenario (GBS) learning environments focuses on a training module designed to prepare consultants with new skills in managing clients, designing user-friendly graphical computer interfaces, and working in a client/server computing environment. Transforming the environment from teaching focused to learning focused is…

Anatomy Education Environment Measurement Inventory: A Valid Tool to Measure the Anatomy Learning Environment

ERIC Educational Resources Information Center

Hadie, Siti Nurma Hanim; Hassan, Asma'; Ismail, Zul Izhar Mohd; Asari, Mohd Asnizam; Khan, Aaijaz Ahmed; Kasim, Fazlina; Yusof, Nurul Aiman Mohd; Manan@Sulong, Husnaida Abdul; Tg Muda, Tg Fatimah Murniwati; Arifin, Wan Nor; Yusoff, Muhamad Saiful Bahri

2017-01-01

Students' perceptions of the education environment influence their learning. Ever since the major medical curriculum reform, anatomy education has undergone several changes in terms of its curriculum, teaching modalities, learning resources, and assessment methods. By measuring students' perceptions concerning anatomy education environment,…

Apprentissage et Environment (Learning and Environment)

ERIC Educational Resources Information Center

Care, Jean-Marc

1977-01-01

Detailed typical daily program in the life of an American and a Moroccan teenager introduces the discussion of the influence of the environment on the learning process, particularly on foreign language learning. A "kit" method for responding to needs determined by the environment is described. (Text is in French.) (AMH)

The Prepared Environment and Its Relationship to Learning.

ERIC Educational Resources Information Center

Loeffler, Margaret Howard

A "prepared environment" is a planned learning facility for young children which offers a supportive and stimulating environment. Current thinking on early learning and the resultant implications for the design of a physical environment which would encourage conceptual development are examined in this book. Each section considers a particular…

An Empirical Verification of a-priori Learning Models on Mailing Archives in the Context of Online Learning Activities of Participants in Free\\Libre Open Source Software (FLOSS) Communities

ERIC Educational Resources Information Center

Mukala, Patrick; Cerone, Antonio; Turini, Franco

2017-01-01

Free\\Libre Open Source Software (FLOSS) environments are increasingly dubbed as learning environments where practical software engineering skills can be acquired. Numerous studies have extensively investigated how knowledge is acquired in these environments through a collaborative learning model that define a learning process. Such a learning…

Directive versus Facilitative Peer Tutoring? A View on Students' Appraisal, Reported Learning Gains and Experiences within Two Differently-Tutored Learning Environments

ERIC Educational Resources Information Center

Berghmans, Inneke; Michiels, Lotte; Salmon, Sara; Dochy, Filip; Struyven, Katrien

2014-01-01

The present study aimed to shed light on students' appraisal and reported learning gains in two differently-tutored learning environments (i.e. directively and facilitatively tutored). In order to investigate this, a quasi-experimental study was set up in the context of a clinical skills learning environment. Not only were participating…

Smart Learning Adoption in Employees and HRD Managers

ERIC Educational Resources Information Center

Lee, Junghwan; Zo, Hangjung; Lee, Hwansoo

2014-01-01

The innovation of online technologies and the rapid diffusion of smart devices are changing workplace learning environment. Smart learning, as emerging learning paradigm, enables employees' learning to take place anywhere and anytime. Workplace learning studies, however, have focused on traditional e-learning environment, and they have failed…

Perception of hospital learning environment: a survey of Hong Kong nursing students.

PubMed

Chan, Dominic S K; Ip, Wan Y

2007-10-01

The last two decades have seen widespread changes to nurse education but the clinical field remains an essential and invaluable resource in preparing students for the reality of their professional role, supporting the integration of theory and practice, and linking the 'knowing what' to do with the 'knowing how' to deliver care. The clinical learning environment represents a vital element of nurse education that needs to be measurable and warrants further investigation. This survey study examined Hong Kong nursing students' perception of the social climate of the clinical learning environment. Participants were invited to complete the two versions, the Actual and Preferred Forms, of the Clinical Learning Environment Inventory following the completion of their clinical field placement. Two hundred eighty one Actual Forms and 243 Preferred Forms returned. SPPS version 11 was employed to analyse data with descriptive and inferential statistics. It was found that there were significant differences between students' perceptions of the actual clinical learning environment and the ideal clinical learning environment they desired. The study highlights the need for a supportive clinical learning environment which is of paramount importance for students in clinical practice.

Relationship between clinical fieldwork educator performance and health professional students' perceptions of their practice education learning environments.

PubMed

Brown, Ted; Williams, Brett; Lynch, Marty

2013-12-01

The Dundee Ready Education Environment Measure, Clinical Teaching Effectiveness Instrument, and Clinical Learning Environment Inventory were completed by 548 undergraduate students (54.5% response rate) enrolled in eight health professional bachelor degree courses. Regression analysis was used to investigate the significant predictors of the Clinical Teaching Effectiveness Instrument with the Dundee Ready Education Environment Measure and Clinical Learning Environment Inventory subscales as independent variables. The results indicated that the Dundee Ready Education Environment Measure and Clinical Learning Environment Inventory Actual version subscale scores explained 44% of the total variance in the Clinical Teaching Effectiveness Instrument score. The Dundee Ready Education Environment Measure subscale Academic Self-Perception explained 1.1% of the variance in the Clinical Teaching Effectiveness Instrument score. The Clinical Learning Environment Inventory Actual subscales accounted for the following variance percentages in the Clinical Teaching Effectiveness Instrument score: personalization, 1.1%; satisfaction, 1.7%; task orientation, 5.1%; and innovation, 6.2%. Aspects of the clinical learning environment appear to be predictive of the effectiveness of the clinical teaching that students experience. Fieldwork educator performance might be a significant contributing factor toward student skill development and practitioner success. © 2013 Wiley Publishing Asia Pty Ltd.

Nursing students' satisfaction of the clinical learning environment: a research study.

PubMed

Papastavrou, Evridiki; Dimitriadou, Maria; Tsangari, Haritini; Andreou, Christos

2016-01-01

The acquisition of quality clinical experience within a supportive and pedagogically adjusted clinical learning environment is a significant concern for educational institutions. The quality of clinical learning usually reflects the quality of the curriculum structure. The assessment of the clinical settings as learning environment is a significant concern within the contemporary nursing education. The nursing students' satisfaction is considered as an important factor of such assessment, contributing to any potential reforms in order to optimize the learning activities and achievements within clinical settings. The aim of the study was to investigate nursing students' satisfaction of the clinical settings as learning environments. A quantitative descriptive, correlational design was used. A sample of 463 undergraduate nursing students from the three universities in Cyprus were participated. Data were collected using the Clinical Learning Environment, Supervision and Nurse Teacher (CLES + T). Nursing students were highly satisfied with the clinical learning environment and their satisfaction has been positively related to all clinical learning environment constructs namely the pedagogical atmosphere, the Ward Manager's leadership style, the premises of Nursing in the ward, the supervisory relationship (mentor) and the role of the Nurse Teacher (p < 0.001). Students who had a named mentor reported more satisfied with the supervisory relationship. The frequency of meetings among the students and the mentors increased the students' satisfaction with the clinical learning environment. It was also revealed that 1st year students were found to be more satisfied than the students in other years. The supervisory relationship was evaluated by the students as the most influential factor in their satisfaction with the clinical learning environment. Student's acceptance within the nursing team and a well-documented individual nursing care is also related with students' satisfaction. The pedagogical atmosphere is considered pivotal, with reference to students' learning activities and competent development within the clinical setting. Therefore, satisfaction could be used as an important contributing factor towards the development of clinical learning environments in order to satisfy the needs and expectations of students. The value of the development of an organized mentorship system is illustrated in the study.

Implementing an Active Learning Environment to Influence Students' Motivation in Biochemistry

ERIC Educational Resources Information Center

Cicuto, Camila Aparecida Tolentino; Torres, Bayardo Baptista

2016-01-01

The Biochemistry: Biomolecules Structure and Metabolism course's goal is to promote meaningful learning through an active learning environment. Thus, study periods (SP) and discussion groups (DG) are used as a substitute for lecture classes. The goal of this study was to evaluate how this learning environment influences students' motivation (n =…

Using Coherence Analysis to Characterize Self-Regulated Learning Behaviours in Open-Ended Learning Environments

ERIC Educational Resources Information Center

Segedy, James R.; Kinnebrew, John S.; Biswas, Gautam

2015-01-01

Researchers have long recognized the potential benefits of open-ended computer- based learning environments (OELEs) to help students develop self-regulated learning (SRL) behaviours. However, measuring self-regulation in these environments is a difficult task. In this paper, we present our work in developing and evaluating "coherence…

Emotional Presence in Online Learning Scale: A Scale Development Study

ERIC Educational Resources Information Center

Sarsar, Firat; Kisla, Tarik

2016-01-01

Although emotions are not a new topic in learning environments, the emerging technologies have changed not only the type of learning environments but also the perspectives of emotions in learning environments. This study designed to develop a survey to assist online instructors to understand students' emotional statement in online learning…

Validation of a Spanish Version of the Distance Education Learning Environments Survey (DELES) in Spain

ERIC Educational Resources Information Center

Fernández-Pascual, Maria Dolores; Ferrer-Cascales, Rosario; Reig-Ferrer, Abilio; Albaladejo-Blázquez, Natalia; Walker, Scott L.

2015-01-01

The aim of this study was to examine the validity of the Spanish version of the Distance Education Learning Environments Survey (Sp-DELES). This instrument assesses students' perceptions of virtual learning environments using six scales: Instructor Support, Student Interaction and Collaboration, Personal Relevance, Authentic Learning, Active…

The Relationship between Motivation, Learning Strategies and Choice of Environment whether Traditional or Including an Online Component

ERIC Educational Resources Information Center

Clayton, Karen; Blumberg, Fran; Auld, Daniel P.

2010-01-01

This study examined how students' achievement goals, self-efficacy and learning strategies influenced their choice of an online, hybrid or traditional learning environment. One hundred thirty-two post-secondary students completed surveys soliciting their preferences for learning environments, reasons for their preference, their motivational…

Open Learning Environments and the Impact of a Pedagogical Agent

ERIC Educational Resources Information Center

Clarebout, Geraldine; Elen, Jan

2006-01-01

Research reveals that in highly structured learning environments pedagogical agents can act as tools to direct students' learning processes by providing content or problem solving guidance. It has not yet been addressed whether pedagogical agents have a similar impact in more open learning environments that aim at fostering students' acquisition…

Clinical Environment as a Learning Environment: Student Nurses' Perceptions Concerning Clinical Learning Experiences.

ERIC Educational Resources Information Center

Papp, Inkeri; Markkanen, Marjatta; von Bonsdorff, Mikaela

2003-01-01

Finnish student nurses (n=16) described their clinical learning experiences. Several themes were identified: feeling appreciated and supported, the quality of mentoring and patient care, and self-directedness. School and clinical staff cooperation helped create a good learning environment in which theory and practice complemented each other.…

Determinants of Computer Self-Efficacy--An Examination of Learning Motivations and Learning Environments

ERIC Educational Resources Information Center

Hsu, Wen-Kai K.; Huang, Show-Hui S.

2006-01-01

The purpose of this article is to discuss determinants of computer self-efficacy from the perspective of participant internal learning motivations and external learning environments. The former consisted of three motivations--interest, trend, and employment--while the latter comprised two environments--home and school. Through an intermediate…

Architecture and Children: Learning Environments and Design Education.

ERIC Educational Resources Information Center

Taylor, Anne, Ed.; Muhlberger, Joe, Ed.

1998-01-01

This issue addresses (1) growing international interest in learning environments and their effects on behavior, and (2) design education, an integrated model for visual-spatial lifelong learning. It focuses on this new and emerging integrated field which integrates elements in education, new learning environment design, and the use of more two-…

Learning System Design Consideration in Creating an Online Learning Environment.

ERIC Educational Resources Information Center

Schaffer, Scott

This paper describes the design of a Web-based learning environment for leadership facilitators in a United States military organization. The overall aim of this project was to design a prototype of an online learning environment that supports leadership facilitators' knowledge development in the content area of motivation. The learning…

Learning Environments as Basis for Cognitive Achievements of Students in Basic Science Classrooms in Nigeria

ERIC Educational Resources Information Center

Atomatofa, Rachel; Okoye, Nnamdi; Igwebuike, Thomas

2016-01-01

The nature of classroom learning environments created by teachers had been considered very important for learning to take place effectively. This study investigated the effect of creating constructivist and transmissive learning environments on achievements of science students of different ability levels. 243 students formed the entire study…

The Effects of Different Learning Environments on Students' Motivation for Learning and Their Achievement

ERIC Educational Resources Information Center

Baeten, Marlies; Dochy, Filip; Struyven, Katrien

2013-01-01

Background: Research in higher education on the effects of student-centred versus lecture-based learning environments generally does not take into account the psychological need support provided in these learning environments. From a self-determination theory perspective, need support is important to study because it has been associated with…

Preservice Teachers' Perception and Use of Personal Learning Environments (PLEs)

ERIC Educational Resources Information Center

Sahin, Sami; Uluyol, Çelebi

2016-01-01

Personal learning environments (PLEs) are Web 2.0 tools and services by which users' access, construct, manage, and share educational contents in order to meet their learning needs. These environments enable users to manage their learning according to their own personal preferences. They further promote socialization and collaboration with their…

Seamless Learning Environments in Higher Education with Mobile Devices and Examples

ERIC Educational Resources Information Center

Marín, Victoria I.; Jääskelä, Päivikki; Häkkinen, Päivi; Juntunen, Merja; Rasku-Puttonen, Helena; Vesisenaho, Mikko

2016-01-01

The use of seamless learning environments that have the potential to support lifelong learning anytime and anywhere has become a reality. In this sense, many educational institutions have started to consider introducing seamless learning environments into their programs. The aim of this study is to analyze how various educational university…