Science.gov

Sample records for lentes tecnis z-9000

  1. Clinical Outcomes after Uncomplicated Cataract Surgery with Implantation of the Tecnis Toric Intraocular Lens

    PubMed Central

    Lubiński, Wojciech; Kaźmierczak, Beata; Gronkowska-Serafin, Jolanta; Podborączyńska-Jodko, Karolina

    2016-01-01

    Purpose. To evaluate the clinical outcomes after uncomplicated cataract surgery with implantation of an aspheric toric intraocular lens (IOL) during a 6-month follow-up. Methods. Prospective study including 27 consecutive eyes of 18 patients (mean age: 66.1 ± 11.4 years) with a visually significant cataract and corneal astigmatism ≥ 0.75 D and undergoing uncomplicated cataract surgery with implantation of the Tecnis ZCT toric IOL (Abbott Medical Optics). Visual, refractive, and keratometric outcomes as well as IOL rotation were evaluated during a 6-month follow-up. At the end of the follow-up, patient satisfaction and perception of optical/visual disturbances were also evaluated using a subjective questionnaire. Results. At 6 months after surgery, mean LogMAR uncorrected (UDVA) and corrected distance visual acuity (CDVA) were 0.19 ± 0.12 and 0.14 ± 0.10, respectively. Postoperative UDVA of 20/40 or better was achieved in 92.6% of eyes. Mean refractive cylinder decreased significantly from −3.73 ± 1.96 to −1.42 ± 0.88 D (p < 0.001), while keratometric cylinder did not change significantly (p = 0.44). Mean absolute IOL rotation was 1.1 ± 2.4°, with values of more than 5° in only 2 eyes (6.9%). Mean patient satisfaction score was 9.70 ± 0.46, using a scale from 0 (not at all satisfied) to 10 (very satisfied). No postoperative optical/visual disturbances were reported. Conclusion. Cataract surgery with implantation of the Tecnis toric IOL is an effective method of refractive correction in eyes with corneal astigmatism due to the good IOL positional stability, providing high levels of patient's satisfaction. PMID:27022478

  2. Simplificando a luneta com lente de óculos

    NASA Astrophysics Data System (ADS)

    Canalle, J. B. G.; de Souza, A. C. F.

    2003-08-01

    A principal ferramenta de trabalho do astrônomo é o telescópio. O manuseio do mesmo é sempre motivo de enorme curiosidade por parte de alunos do ensino fundamental ou médio e até mesmo dos respectivos professores. Visando propiciar o acesso de alunos e professores ou interessados em geral a uma luneta de fácil construção, com materiais alternativos, de fácil localização no comércio, de baixo custo, resistente ao manuseio de alunos, simplificamos a montagem de uma luneta construída com lente de óculos, de 1 ou 2 graus positivos, e monóculo de fotografia, publicado por este autor no CCEF, vol.11(3), 212, 1994. Esta luneta, a qual permite ver as crateras lunares, apresentava como maior dificuldade de construção o tripé e o local de formação da imagem. Substituímos o tripé de madeira por uma simples garrafa PET de 2 litros cheia d'água. No lugar da ocular usamos a lente do monóculo de fotografia (ou visor de fotografia) encaixado dentro de uma bucha de redução curta, de 40 x 32 mm, e esta não mais dentro de uma luva (conexão hidráulica) de 40 mm de diâmetro, mas sim encostada no próprio tubo de PVC móvel (o qual permite o ajuste do foco) de 40 mm de diâmetro e presa a este por outro tubo de 40 mm de diâmetro e 10 cm de comprimento, serrado ao longo do seu comprimento. Com isto podemos ajustar a posição deste tubo de 10 cm também para que uma das suas extremidades coincida com o local de formação da imagem. Desta forma o observador saberá o local exato da formação da imagem, o que não era evidente na montagem anterior e causava uma dificuldade inicial até se descobrir a posição exata em que se deveria colocar o olho. Deste maneira, a montagem inicial que já era simples ficou ainda mais simples, mais barata e mais confortável para o uso. Um exemplar da mesma será exposto durante a XXIX Reunião Anual da Sociedade Astronômica Brasileira para inspeção e uso dos participantes.

  3. Stochastic fluctuations and chiral symmetry breaking: exact solution of Lente model.

    PubMed

    Shao, Jiushu; Liu, Lan

    2007-09-27

    The stochastic description for the autocatalytic process has been proposed by Lente (J. Phys. Chem. A 2004, 108, 9475) to demonstrate chiral symmetry breaking. He assumed that the number of reacting molecules is macroscopic and that no products are present initially. The Lente model consisting of a finite number of molecules that may include the product molecules as chiral seeds is explored and the characteristics of stochastic distributions of the product are examined. It is shown that the presence of racemic product in the substrate reduces the possibility of chiral symmetry breaking while a few more molecules of a specific enantiomer added can yield chiral dominance for strong autocatalysis. Besides, small reactive volumes or dense reactant concentrations have a preference for chiral symmetric breaking.

  4. 12 CFR 7.1003 - Money lent at banking offices or at other than banking offices.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...(j) and 12 CFR 5.30, “money” is deemed to be “lent” only at the place, if any, where the borrower in... without violating 12 U.S.C. 36, 12 U.S.C. 81 and 12 CFR 5.30, provided that a third party is used to... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Money lent at banking offices or at other...

  5. 12 CFR 7.1003 - Money lent at banking offices or at other than banking offices.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...(j) and 12 CFR 5.30, “money” is deemed to be “lent” only at the place, if any, where the borrower in... without violating 12 U.S.C. 36, 12 U.S.C. 81 and 12 CFR 5.30, provided that a third party is used to... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Money lent at banking offices or at other...

  6. 12 CFR 7.1003 - Money lent at banking offices or at other than banking offices.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...(j) and 12 CFR 5.30, “money” is deemed to be “lent” only at the place, if any, where the borrower in... without violating 12 U.S.C. 36, 12 U.S.C. 81 and 12 CFR 5.30, provided that a third party is used to... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Money lent at banking offices or at other...

  7. 12 CFR 7.1003 - Money lent at banking offices or at other than banking offices.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...(j) and 12 CFR 5.30, “money” is deemed to be “lent” only at the place, if any, where the borrower in... without violating 12 U.S.C. 36, 12 U.S.C. 81 and 12 CFR 5.30, provided that a third party is used to... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Money lent at banking offices or at other...

  8. 12 CFR 7.1003 - Money lent at banking offices or at other than banking offices.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...(j) and 12 CFR 5.30, “money” is deemed to be “lent” only at the place, if any, where the borrower in... without violating 12 U.S.C. 36, 12 U.S.C. 81 and 12 CFR 5.30, provided that a third party is used to... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Money lent at banking offices or at other...

  9. Estatística de lentes gravitacionais e o gás de chaplygin generalizado

    NASA Astrophysics Data System (ADS)

    Oliveira, A. L. S.

    2003-08-01

    A estatística de lentes gravitacionais constitui uma poderosa ferramenta utilizada na obtenção de vínculos sobre parâmetros cosmológicos, principalmente sobre modelos com uma constante cosmológica. Embora de forma às vezes controversa, antes de 1998, a análise tradicional mostrava que modelos com o parâmetro de densidade da matéria da ordem da unidade são preferidos. Esse resultado começou a ser questionado, alguns anos atrás, com as indicações, advindas da análise de supernovas com alto valor de desvio para o vermelho, de que nosso Universo está acelerando. Atualmente há enorme interesse em saber qual é a natureza da componente responsável pela aceleração cósmica. Energia escura é a denominação usual dessa componente e sua característica principal é possuir pressão negativa. Nos modelos cosmológicos tradicionais, além da energia escura, considera-se também uma outra componente de origem desconhecida. Ela é denominada matéria escura e possui pressão nula. Mais recentemente modelos unificadores em que energia escura e matéria escura são manifestações distintas de um mesmo fluido (altas densidades matéria escura, baixas densidades energia escura) foram sugeridos. Um desses modelos é conhecido como Gás de Chaplygin Generalizado que é o modelo que investigaremos. Em nosso trabalho apresentamos vínculos sobre parâmetros desse modelo usando a estatística de lentes gravitacionais. Usamos observações de quasares na faixa do visível e consideramos extinção em nosso estudo. Análises semelhantes anteriores com esse tipo de objetos e que não consideram extinção são inconsistentes. Comparação dos vínculos obtidos através de lentes gravitacionais com outros advindos de outros testes será também apresentada.

  10. Assessment of the insecticidal potential of Eucalyptus urograndis essential oil against Rhodnius neglectus Lent (Hemiptera: Reduviidae).

    PubMed

    Gomes, S P; Favero, S

    2013-08-01

    The resistance of triatomines to pyrethroids has been reported in several Latin American countries, including Brazil, indicating the need for the development of new approaches for the control of vectors of the Chagas disease. In here, we evaluated the insecticidal potential of the essential oil of Eucalyptus urograndis (Myrtaceae) against unsexed third and fourth instars of Rhodnius neglectus Lent (Hemiptera: Reduviidae) in topical application, fumigation, surface contact, and repellency . The insecticidal activity of the essential oil tested was detected by topical application (LD50 = 0.1731 μL/insect and LD99 = 0.2948 μL/insect for 24 h), fumigation (LC50 = 0.021 mL/mL air and LC99 = 0.1525 mL/mL air for 24 h) and surface contact (LC50 = 0.7073 μL/cm(2) and LC99 = 4.59 μL/cm(2) for 24 h). Mortality observed after 48-72-h exposure was very high and did not allow for any adjustment of the mortality curve. In the repellency assay, an effect was observed on 80% of tested nymphs. However, no repellency was observed after 24 h of exposure. Eucalyptus urograndis essential oil has a high insecticidal and repellent potential for R. neglectus nymphs, whether serving as a molecular model for new substances or as an alternative for the control of these insects.

  11. Assessment of the insecticidal potential of Eucalyptus urograndis essential oil against Rhodnius neglectus Lent (Hemiptera: Reduviidae).

    PubMed

    Gomes, S P; Favero, S

    2013-08-01

    The resistance of triatomines to pyrethroids has been reported in several Latin American countries, including Brazil, indicating the need for the development of new approaches for the control of vectors of the Chagas disease. In here, we evaluated the insecticidal potential of the essential oil of Eucalyptus urograndis (Myrtaceae) against unsexed third and fourth instars of Rhodnius neglectus Lent (Hemiptera: Reduviidae) in topical application, fumigation, surface contact, and repellency . The insecticidal activity of the essential oil tested was detected by topical application (LD50 = 0.1731 μL/insect and LD99 = 0.2948 μL/insect for 24 h), fumigation (LC50 = 0.021 mL/mL air and LC99 = 0.1525 mL/mL air for 24 h) and surface contact (LC50 = 0.7073 μL/cm(2) and LC99 = 4.59 μL/cm(2) for 24 h). Mortality observed after 48-72-h exposure was very high and did not allow for any adjustment of the mortality curve. In the repellency assay, an effect was observed on 80% of tested nymphs. However, no repellency was observed after 24 h of exposure. Eucalyptus urograndis essential oil has a high insecticidal and repellent potential for R. neglectus nymphs, whether serving as a molecular model for new substances or as an alternative for the control of these insects. PMID:23949865

  12. Apport de l’IRM dans la prise en charge des compressions médullaires lentes non traumatiques

    PubMed Central

    Badji, Nfally; Deme, Hamidou; Akpo, Geraud; Ndong, Boucar; Toure, Mouhamadou Hamine; Diop, Sokhna Ba; Niang, El Hadji

    2016-01-01

    Les compressions médullaires lentes sont dues au développement dans le canal médullaire d’une lésion expansive. C’est une pathologie très fréquente dont le diagnostic est essentiellement clinique. L’imagerie par résonnance magnétique occupe une place incontournable dans le diagnostic de localisation et la recherche étiologique. En Europe l’étiologie tumorale est prépondérante. Le but de cette étude était de décrire les aspects IRM des compressions médullaires lentes et de déterminer le profil étiologique. Il s’agit d’une étude rétrospective portant sur 97 observations colligées au service de radiologie du CHUN de Fann sur une période de 30 mois (du 08/03/10 au 29/09/12). On été inclus dans l’étude, tous les patients adressés pour un tableau de compression médullaire lente survenu dans un contexte non traumatique. L’âge moyen des patients était de 42,6 ans avec des extrêmes compris entre 04 mois et 85 ans. Nous avons étudié la topographie des lésions (étage rachidien, compartiments canalaires) leur rehaussement et les critères d’orientation étiologique. Le protocole d’examen permettait la réalisation de séquence pondérées T1 sans avec injection de gado, T2, STIR et T2 DRIVE centrées sur les niveaux lésionnels ou les zones suspectes. L’IRM a permis de préciser le siège exact et l’étendue des lésions. L’atteinte du rachis dorsal représentait 42% des cas, suivi du rachis cervical avec 32% des cas. Les atteintes lombo-sacrées et pluri-étagées représentaient respectivement 18% et 08% des cas. Les lésions extradurales représentaient 87% des cas, suivi des lésions intradurales extramédullaires avec 08% des cas et des lésions intramédullaires dans 05% des cas. La particularité du profil étiologique de notre étude est la prédominance des épidurites infectieuses et la fréquence relative des épidurites métastatiques comparée aux séries occidentales. L’IRM vertébro-médullaire occupe

  13. Detecção inesperada de efeitos de lentes fracas em grupos de galáxias pouco luminosos em raios-X

    NASA Astrophysics Data System (ADS)

    Carrasco, R.; Mendes de Oliveira, C.; Sodrã©, L., Jr.; Lima Neto, G. B.; Cypriano, E. S.; Lengruber, L. L.; Cuevas, H.; Ramirez, A.

    2003-08-01

    Obtivemos, como parte do programa de verificação científica do GMOS Sul, imagens profundas de três grupos de galáxias: G97 e G102 (z~0,4) e G124 (z = 0,17). Esses alvos foram selecionados a partir do catálogo de fontes extensas de Vikhlinin (1998), por terem luminosidades em raios X menores que 3´1043 ergs s-1, valor cerca de uma ou duas ordens de grandeza inferior ao de aglomerados de galáxias. O objetivo primário dessas observações é o estudo da evolução de galáxias em grupos. Grupos são ambientes menos densos que aglomerados, contêm a grande maioria das galáxias do Universo mas que, até o momento, foram estudados detalhadamente apenas no Universo local (z~0). Com esses dados efetuamos uma análise estatística da distorção na forma das galáxias de fundo (lentes gravitacionais fracas) como forma de inferir o conteúdo e a distribuição de massa nesses grupos apesar de que, em princípio, esse efeito não deveria ser detectado uma vez que os critérios de seleção adotados previlegiam sistemas de baixa massa. De fato, para G124 obtivemos apenas um limite superior para sua massa que é compatível com sua luminosidade em raios X. De modo contrário e surpreendente, os objetos G102 e G097, aparentam ter massas que resultariam em dispersões de velocidade maiores que 1000 km s-1, muito maiores do que se espera para grupos de galáxias. Com efeito, para G097 obtivemos, a partir de dados do satélite XMM, uma estimativa para a temperatura do gás intragrupo de kT = 2,6 keV, que é tipica de sistemas com dispersões de velocidade de ~ 600 km s-1, bem característica de grupos. Essas contradições aparentes entre lentes fracas e raios X podem ser explicadas de dois modos: i) a massa obtida por lentes estaria sobreestimada devido à superposição de estruturas massivas ao longo da linha de visada ou ii) a temperatura do gás do meio intra-grupo reflete o potencial gravitacional de estruturas menores que estariam se fundindo para formar uma

  14. Description of the male genitalia of Belminus rugulosus Stål and Belminus corredori Galvão & Angulo, and comments on the holotype of Parabelminus yurupucu Lent & Wygodzinsky (Hemiptera: Heteroptera: Reduviidae: Triatominae: Bolboderini).

    PubMed

    Gil-Santana, Hélcio R; Galvão, Cleber

    2013-12-13

    The male genitalia of Belminus rugulosus Stål and Belminus corredori Galvão & Angulo are described and illustrated for the first time. Comments on the holotype of Parabelminus yurupucu Lent & Wygodzinsky are presented (Hemiptera: Heteroptera: Reduviidae: Triatominae: Bolboderini). A discussion on previous data in the literature on male genitalia of species of Belminus Stål is provided.

  15. Long-term results of adjuvant imatinib mesylate in localized, high-risk, primary gastrointestinal stromal tumor (GIST): ACOSOG Z9000 (Alliance) intergroup phase 2 trial

    PubMed Central

    DeMatteo, Ronald P.; Ballman, Karla V.; Antonescu, Cristina R.; Corless, Christopher; Kolesnikova, Violetta; von Mehren, Margaret; McCarter, Martin D.; Norton, Jeffrey; Maki, Robert G.; Pisters, Peter W.T.; Demetri, George D.; Brennan, Murray F.; Owzar, Kouros

    2014-01-01

    Objective To conduct the first adjuvant trial of imatinib mesylate for treatment of gastrointestinal stromal tumor (GIST). Summary Background Data GIST is the most common sarcoma. While surgical resection has been the mainstay of therapy for localized, primary GIST, postoperative tumor recurrence is common. The KIT proto-oncogene or, less frequently, platelet-derived growth factor receptor alpha (PDGFRA) is mutated in GIST; the gene products of both are inhibited by imatinib mesylate. Methods This was a phase II, intergroup trial led by the American College of Surgeons Oncology Group (ACOSOG), registered at ClinicalTrials.gov as NCT00025246. From 09/2001 to 09/2003, we accrued 106 patients who had undergone complete gross tumor removal but were deemed at high risk for recurrence. Patients were prescribed imatinib 400 mg/day for 1 year and followed with serial radiologic evaluation. The primary endpoint was overall survival (OS). Results After a median follow-up of 7.7 years, the 1-, 3-, and 5-year OS rate was 99, 97, and 83%, which compared favorably with a historical 5 year OS rate of 35%. The 1-, 3-, and 5-year RFS rate was 96, 60, and 40%. On univariable analysis, age and mitotic rate were associated with OS. On multivariable analysis, the RFS rate was lower with increasing tumor size, small bowel site, KIT exon 9 mutation, high mitotic rate, and older age. Conclusion Adjuvant imatinib in patients with primary GIST who are at high risk of recurrence prolongs OS compared to that of historical controls. Optimal duration of adjuvant therapy remains undefined. (NCT00025246) PMID:23860199

  16. An Excel-lent Card Trick

    ERIC Educational Resources Information Center

    Zullo, Holly S.

    2011-01-01

    Card tricks based on mathematical principles can be a great way to get students interested in exploring some important mathematical ideas. In this article, the author discusses a simple spreadsheet implementation that shows students why the card trick works and allows them to explore several variations. As an added bonus, students are introduced…

  17. Etude de l'effet de la température de dépôt ou de recuit sur la formation de l'interface Au/GaSb(100) par diffraction d'électrons lents et spectroscopies d'électrons Auger ou de pertes d'énergies

    NASA Astrophysics Data System (ADS)

    Rouanet, M.; Oueini, W.; Nouaoura, M.; Bertru, N.; Bonnet, J.; Lassabatere, L.

    1995-05-01

    Auger electron spectroscopy (AES), energy electron loss spectroscopy (EELS) and low energy electron diffraction (LEED) are used to precise the interaction of gold with GaSb(100) surfaces grown on GaSb substrates by molecular beam epitaxy (MBE). After the growth, the GaSb layers, produced in the laboratory, were transferred by the mean of an ultra vacuum lock chamber, into an other ultra vacuum devoted to the deposit of gold and to the physical studies. Measurements were first performed on the clean surfaces and then on surfaces covered by increasing amounts of gold (6 × 10^{13} 1.8 × 10^{16} atoms cm^{-2}) deposited on substrates brought at room temperature or at low temperature (220 K). The samples were then studied during the annealing up to 520 K. The results show, at the beginning of the deposition, gold was adsorbed on the MBE GaSb(100) surface. When the gold coverage increases and becomes higher than 10^{15} atomes cm^{-2}, Au diffuses into the bulk and forms alloys. Nous étudions par spectroscopie d'électrons Auger (SEA), spectroscopie de pertes d'énergies d'électrons lents (SPEEL) et diffraction d'électrons lents (DEL), l'adsorption de l'or sur des surfaces (100) de couches de GaSb obtenues au laboratoire par épitaxie par jets moléculaires (EJM) sur des substrats de GaSb, puis transférées pour dépôt et étude dans l'enceinte à ultravvide de dépôt métallique par l'intermédiaire d'un sas sous ultravide. Les mesures sont effectuées avant et après dépôts d'or (6 × 10^{13} 1,8 × 10^{16} atomes cm^{-2}) réalisés sur un substrat à la température ambiante ou refroidi à 220 K. Les échantillons sont ensuite étudiés pendant lerecuit jusqu'à 520 K. Les résultats obtenues montrent que l'or, dans un premier temps s'adsorbe sur la surface, puis, lorsque le dépôt augmente, diffuse dans le volume du matériau. cette diffusion, qui peut s'acompagner de la formation d'alliages, n'est cependant notable dans la gamme de température utilis

  18. "I Gave up MySpace for Lent": New Teachers and Social Networking Sites

    ERIC Educational Resources Information Center

    Kist, William

    2008-01-01

    This Digital Literacies column describes the dilemma many new teachers feel as their uses of social networking sites pose conflicts with institutional cautions regarding educators' participation in these kinds of online activities. Pre-service teachers discuss the challenges of marrying their own out-of-school literacies to mandated professional…

  19. Prominence lent by rising and falling pitch movements: Testing two models.

    PubMed

    Rump, H H; Hermes, D J

    1996-08-01

    Two experiments are reported in which a pitch-level difference (PLD) model for prominence perception [Hermes and Rump, J. Acoust. Soc. Am. 96, 83-92 (1994)] is subjected to further tests. The model holds that the contribution of pitch to the perceived degree of prominence is proportional to the difference in pitch level between the vocalic nuclei of the accented and the previous syllable. In experiment I, the influence of stretching and compressing the utterance in time was assessed. It was found that the predictions made by the model were not fully supported by the data. An alternative model was developed according to which pitch movements resynthesized in the same register lend equal prominence when pitch levels on the upper declination lines in the stimuli are equal. These two models gave different predictions when the lower declination lines are different. This was tested in experiment II. The results which are more or less between the predictions by the two models suggest that low pitch levels play a smaller role in prominence perception than high pitch levels do. PMID:8759965

  20. School-Wide Success Builds on 'ExCEL'lent Program

    ERIC Educational Resources Information Center

    Boutelle, Marsha

    2008-01-01

    It's not often that the goals of closing the achievement gap, providing professional development opportunities to teachers, and benefiting children by using innovative and effective instructional methods coincide. But at Sutterville Elementary School in Sacramento, CA, they do. This article describes the School-Wide Success (SWS) program, its…

  1. 48 CFR 252.223-7008 - Prohibition of Hexava-lent Chromium.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the Contracting Officer, the Contractor shall not provide any deliverable or construction material... chromium materials during subsequent sustainment phases of the deliverable or construction material. (2... services, or construction materials. (End of clause)...

  2. New record and cytogenetic analysis of Psammolestes tertius Lent & Jurberg, 1965 (Hemiptera, Reduviidae, Triatominae) from Bahia State, Brazil.

    PubMed

    Oliveira, J; Alevi, K C C; Fonseca, E O L; Souza, O M F; Santos, C G S; Azeredo-Oliveira, M T V; da Rosa, J A

    2016-06-20

    This paper reports on the first occurrence of Psammolestes tertius in the Chapada Diamantina region, located in the city of Seabra, Bahia State, in northeastern Brazil. Following an active search, 24 P. tertius specimens were collected from Phacellodomus rufifrons (rufous-fronted thornbird) nests. The insects did not present any symptoms of infection by Trypanosoma cruzi. P. tertius males were cytogenetically analyzed, and the results were compared with those of other specimens from the Brazilian State of Ceará. Triatomines from both locations presented the same cytogenetic characteristics: 22 chromosomes, little variation in the size of the autosomes, Y chromosomes that were larger than the X chromosomes, a chromocenter formed only by the sex chromosomes during prophase, and autosomes lacking constitutive heterochromatin. However, it is important to note that this species shows intraspecific chromosomal variation. In light of the results obtained, it is recommended that more studies be performed to characterize P. tertius. These studies will be particularly helpful in understanding this species in ecological, biological, biogeographical, and phylogenetic terms.

  3. New record and cytogenetic analysis of Psammolestes tertius Lent & Jurberg, 1965 (Hemiptera, Reduviidae, Triatominae) from Bahia State, Brazil.

    PubMed

    Oliveira, J; Alevi, K C C; Fonseca, E O L; Souza, O M F; Santos, C G S; Azeredo-Oliveira, M T V; da Rosa, J A

    2016-01-01

    This paper reports on the first occurrence of Psammolestes tertius in the Chapada Diamantina region, located in the city of Seabra, Bahia State, in northeastern Brazil. Following an active search, 24 P. tertius specimens were collected from Phacellodomus rufifrons (rufous-fronted thornbird) nests. The insects did not present any symptoms of infection by Trypanosoma cruzi. P. tertius males were cytogenetically analyzed, and the results were compared with those of other specimens from the Brazilian State of Ceará. Triatomines from both locations presented the same cytogenetic characteristics: 22 chromosomes, little variation in the size of the autosomes, Y chromosomes that were larger than the X chromosomes, a chromocenter formed only by the sex chromosomes during prophase, and autosomes lacking constitutive heterochromatin. However, it is important to note that this species shows intraspecific chromosomal variation. In light of the results obtained, it is recommended that more studies be performed to characterize P. tertius. These studies will be particularly helpful in understanding this species in ecological, biological, biogeographical, and phylogenetic terms. PMID:27420943

  4. ?La Maétresse dit que je suis lent?: Représentation de l'école française dans le discours d'élèves immigrés

    NASA Astrophysics Data System (ADS)

    Vasquez, Ana; Proux, Michelle B.

    1984-06-01

    The difficulties of immigrant children at school have generally been studied with the emphasis either on their deficiencies or on the schemes which they devise to enable them to adapt. The study which is presented here, however, aims at a radically different approach by viewing the problem within the theoretical framework of transculturation and by examining the way in which the pupils themselves perceive the French school system. A study is made of the outcome of 101 interviews which were conducted in their mother tongue with Spanish- or Portuguese-speaking boys and girls aged between 10 and 17 years old. On the basis of statistical analysis by computer, indices were formulated with the intention of establishing (a) the relationship between the researcher and the subject during the interview; (b) the links between the subject as an individual and his/her peer-group (`me' — `us'); (c) his/her perception of `others'; and (d) the way in which he/she relates to his/her experience (as something to be positively accepted — or to be suffered; `active' or `passive'). Keywords illustrate and underline the difficulties encountered both by pupils and by the school to grasp the idea of time norms as a cultural shaping and to perceive how relative they are.

  5. Ultrastructure and morphometry of eggs of Triatoma rubrovaria (Blanchard, 1843), Triatoma carcavalloi Juberg, Rocha & Lent, 1998 and Triatoma circummaculata (Stål, 1859) (Hemiptera-Reduviidae-Triatominae).

    PubMed

    Cardozo-de-Almeida, Margareth; Castro-de-Souza, Simone; De Oliveira, Maria Luiza Ribeiro; De Almeida, Sérgio Antônio Silva; Gonçalves, Teresa Cristina Monte; Dos Santos-Mallet, Jacenir Reis

    2013-12-20

    This study analyzed the body and the operculum of eggs of Triatoma rubrovaria, T. carcavalloi and T. circummaculata, considered sylvatic species that live in sympatry.Triatoma rubrovaria is currently considered the most important vector of Trypanosoma cruzi in the rural areas of the state of Rio Grande do Sul, followed by T.circummaculata. Significant differences other than morphometry have been observed in the egg structures of the three species using traditional microscopy and scanning electron microscopy. Triatoma circummaculata eggs are smaller than those of T.rubrovaria and T. carcavalloi. The average number of perforations in corionic cells in the egg body is higher for the T. rubrovaria. The average number of perforations in the operculum cell is higher in T. circummaculata. This is the first morpho-structural description of T. carcavalloi eggs. These results widen the concept of these three species and create new subsidies for the entomological monitoring in areas in which these vectors may infest human living quarters.

  6. El rol de Ia colaboracion y el Modelo de Aprendizaje Basado en Proyectos (ABPr) mediante el lente de la Teoria de Actividad (CHAT): un estudio de caso con estudiantes de 9no grado

    NASA Astrophysics Data System (ADS)

    Delgado, Isabel C.

    Los modelos de eensenanza y aprendizaje constructivistas conceptualizan el aprendizaje como un proceso activo. El modelo de Aprendizaje Basado en Proyectos (ABPr) se distingue por una serie de componentes, entre los cuales se destaca el aspecto colaborativo y cooperativo como un reto al momento de su implantacion. Son pocas las investigaciones que se concentran en este aspecto del modelo. En este estudio, se analizaron las diversas interacciones que surgen durante la implantacion de una unidad curricular sobre el tema de Geologia de Puerto Rico, la cual se diseno con el modelo ABPr cuyo enfoque es orientacion a proyectos. Particularmente, se examinaron las interacciones sociales que surgen entre los pares y entre pares y docente durante el proceso de planificacion y desarrollo de los productos finales, al igual que las interacciones entre los estudiantes y el material didactico en estas etapas del modelo. La investigacion es de tipo cualitativo e incorpora como diseno el estudio de caso. Las diversas interacciones constituyen la unidad de analisis. En el estudio participaron 19 estudiantes de 9no grado, a quienes se organizaron en 5 grupos colaborativos por temas de interes (Pangea, Placas tectonicas, Volcanes, Tsunamis y Terremotos). Las tecnicas que se utilizaron para recopilar los datos fueron: observaciones participativas, grupos focales y analisis de documentos (cuadernos reflexivos y respuestas de los estudiantes a la pregunta central del proyecto). Para el analisis de los datos se aplico la teoria de actividad (CHAT) que concentra la unidad de analisis en la actividad humana en un contexto particular. Los resultados del estudio senalan que las interacciones entre pares, entre pares y docente, asi como entre estudiantes y material didactico son fundamentales en el proceso de aprendizaje. Una mayor interaccion entre pares durante las etapas de planificar y desarrollar los productos finales de la unidad, promueve una mejor comprension de los conceptos de la unidad, segun evidencia los productos finales del ABPr. La interaccion con el docente es muy importante para mediar los conflictos y desacuerdos que surgen como parte de las interacciones entre pares. Por lo tanto, el uso de diversas estrategias de andamiaje por parte del docente durante las reuniones de los grupos colaborativos es esencial para el exito del modelo ABPr.

  7. Early clinical experience with a new preloaded one-piece intraocular lens in paediatric cataract surgery.

    PubMed

    Gosling, D B; Chan, T K J

    2016-09-01

    PurposeTo report the clinical experience of using the Tecnis PCB00 (Abbott Medical Optics, Santa Ana, CA, USA) preloaded one-piece intraocular lens (IOL) in the setting of a tertiary referral centre for paediatric cataract.MethodsA retrospective case note review of all paediatric cataract surgeries using the Tecnis PCB00 IOL, at a single UK paediatric ophthalmology department.ResultsNine eyes in seven patients received the IOL between December 2014 and January 2016. All patients underwent lens aspiration and insertion of the IOL 'in the bag.' The indications for surgery included developmental cataract (8/9) and traumatic cataract (1/9). Mean age at the time of surgery was 7 years (range 2-14). The median improvement in logMAR best-corrected visual acuity was 0.475 (range 0.250-1.500). The mean follow-up duration was 5 months (range 1-13). No operative or post-operative complications occurred as a result of using the device.ConclusionThe Tecnis PCB00 preloaded IOL appears to be a safe and effective device in treating paediatric cataract.

  8. 12 CFR 303.41 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... office, or any branch place of business located in any State of the United States or in any territory of... lent. A branch does not include an automated teller machine, an automated loan machine, a remote... relating to transactions in which deposits are received or checks paid or money lent. A messenger...

  9. Social Cognitive Influences on Mexican Americans' Career Choices across Holland's Themes

    ERIC Educational Resources Information Center

    Flores, Lisa Y.; Robitschek, Chris; Celebi, Elif; Andersen, Christie; Hoang, Uyen

    2010-01-01

    This study examined several propositions of social cognitive career theory ([Lent et al., 1994] and [Lent et al., 2000]) with a sample of 393 Mexican American college students. It was hypothesized that person input (i.e., age) and background contextual variables (i.e., Anglo orientation, Mexican orientation, familism, instrumentality, and…

  10. Test of a Social Cognitive Model of Work Satisfaction in Teachers

    ERIC Educational Resources Information Center

    Duffy, Ryan D.; Lent, Robert W.

    2009-01-01

    Lent and Brown [Lent, R. W., & Brown, S. D. (2006). "Integrating person and situation perspectives on work satisfaction: A social-cognitive view." "Journal of Vocational Behavior,69", 236-247] recently proposed an integrative model of work satisfaction linked to social cognitive career theory. The model posits that work satisfaction is predicted…

  11. A Social Cognitive Perspective on Well-Being in Educational and Work Settings: Cross-Cultural Considerations

    ERIC Educational Resources Information Center

    Sheu, Hung-Bin; Lent, Robert W.

    2009-01-01

    The article gives an overview of a social cognitive perspective on psychosocial well-being and adjustment (Lent, 2004), along with a model of educational and work-related satisfaction (Lent & Brown, 2006) that has been derived from it. The theoretical perspective integrates cognitive, behavioural, social, and personality variables hypothesized to…

  12. Toric intraocular lens orientation and residual refractive astigmatism: an analysis

    PubMed Central

    Potvin, Rick; Kramer, Brent A; Hardten, David R; Berdahl, John P

    2016-01-01

    Purpose To analyze intraocular lens (IOL) orientation data from an online toric back-calculator (astigmatismfix.com) for determining if differences were apparent by lens type. Methods A retrospective review of astigmatismfix.com toric back-calculations that included IOL identification and intended orientation axis. Results Of 12,812 total validated calculation records, 8,229 included intended orientation and lens identification data. Of the latter, 5,674 calculations (69%) involved lenses oriented 5° or more from their intended position. Using estimated toric lens usage data, the percentage of lenses with orientation ≥5° from intended was 0.89% overall, but the percentage varied significantly between specific toric lens brands (P<0.05). The percentage of back-calculations related to lenses that were not oriented as intended was also statistically significantly different by lens brand (P<0.05). When IOLs were misoriented, they were significantly more likely to be misoriented in a counterclockwise direction (P<0.05). This was found to be due to a bias toward counterclockwise orientation observed with one specific brand, a bias that was not observed with the other three brands analyzed here. Conclusion The percentage of eyes with lens orientation ≥5° from intended in the Toric Results Analyzer data set was <1% of toric IOLs in general, with the relative percentage of Tecnis® Toric IOLs significantly higher than AcrySof® Toric IOLs. Both of these had higher rates than the Staar® Toric and Trulign® Toric lenses, with the availability of higher Tecnis and AcrySof cylinder powers a likely contributing factor. The AcrySof Toric IOL appears to be less likely than the Tecnis Toric IOL to cause residual astigmatism as a result of misorientation. The Tecnis Toric IOL appears more likely to be misoriented in a counterclockwise direction; no such bias was observed with the AcrySof Toric, the Trulign® Toric, or the Staar Toric IOLs. PMID:27703323

  13. 2. West and south elevation. Copied from an old print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. West and south elevation. Copied from an old print by Joseph Hill, lent to survey by Evelyn S. Craig. - Jansonist Colony, Steeple Building, Main & Bishop Hill Streets, Bishop Hill, Henry County, IL

  14. 3. West and south elevations. Joseph Hill, photographer, copied from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. West and south elevations. Joseph Hill, photographer, copied from photo lent by Evelyn S. Craig. August 1936. - Jansonist Colony, Steeple Building, Main & Bishop Hill Streets, Bishop Hill, Henry County, IL

  15. 1. Historic American Buildings Survey Joseph Hill, Photographer August 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer August 1936 FIRST ORIGINAL STORE AND POSTOFFICE, COPY OF AN EARLY PHOTOGRAPH. LENT BY EVELYN S. CRAIG - Jansonist Colony, Colony Store & Post Office, Main & Bishop Hill Streets, Bishop Hill, Henry County, IL

  16. Visual acuity and patient satisfaction at varied distances and lighting conditions after implantation of an aspheric diffractive multifocal one-piece intraocular lens

    PubMed Central

    Chang, Daniel H

    2016-01-01

    Purpose The aim of the study is to evaluate the visual acuity and patient satisfaction at varied distances under photopic and mesopic lighting conditions in patients bilaterally implanted with aspheric diffractive multifocal one-piece intraocular lenses. Methods In this retrospective–prospective study, 16 patients with a mean age of 66.2±9.2 years (range: 50–81 years) who had undergone bilateral phacoemulsification surgery with implantation of a Tecnis multifocal one-piece intraocular lens (ZMB00) were evaluated. Monocular and binocular uncorrected and distance-corrected visual acuities were measured at distance (20 ft), intermediate (70–80 cm), and near (35–40 cm) under photopic (85 cd/m2) and mesopic (3 cd/m2) lighting conditions and were compared using the paired t-test. All patients also completed a subjective questionnaire. Results At a mean follow-up of 9.5±3.9 months, distance, near, and intermediate visual acuity improved significantly from preoperative acuity. Under photopic and mesopic conditions, 93.8% and 62.5% of patients, respectively, had binocular uncorrected intermediate visual acuity of 20/40 or better, and 62.5% and 31.3% of patients had binocular uncorrected near visual acuity of 20/20 or better. All patients were satisfied with their overall vision without using glasses and/or contact lenses when compared with before surgery. A total of 87.5% of patients reported no glare and 68.8% of patients reported no halos around lights at night. Conclusion Tecnis multifocal one-piece intraocular lenses provide good distance, intermediate, and near visual acuity under photopic as well as mesopic lighting conditions. High levels of spectacle independence with low levels of photic phenomenon were achieved, resulting in excellent patient satisfaction. PMID:27536061

  17. Simultaneous direct determination of aluminum, calcium and iron in silicon carbide and silicon nitride powders by slurry-sampling graphite furnace AAS.

    PubMed

    Minami, Hirotsugu; Yada, Masako; Yoshida, Tomomi; Zhang, Qiangbin; Inoue, Sadanobu; Atsuya, Ikuo

    2004-03-01

    A fast and accurate analytical method was established for the simultaneous direct determination of aluminum, calcium and iron in silicon carbide and silicon nitride powders by graphite furnace atomic absorption spectrometry using a slurry sampling technique and a Hitachi Model Z-9000 atomic absorption spectrometer. The slurry samples were prepared by the ultrasonication of silicon carbide or silicon nitride powders with 0.1 M nitric acid. Calibration curves were prepared by using a mixed standard solution containing aluminum, calcium, iron and 0.1 M nitric acid. The analytical results of the proposed method for aluminum, calcium and iron in silicon carbide and silicon nitride reference materials were in good agreement with the reference values. The detection limits for aluminum, calcium and iron were 0.6 microg/g, 0.15 microg/g and 2.5 microg/g, respectively, in solid samples, when 200 mg of powdered samples were suspended in 20 ml of 0.1 M nitric acid and a 10 microl portion of the slurry sample was then measured. The relative standard deviation of the determination of aluminum, calcium and iron was 5 - 33%.

  18. Adolescents on the Edge: Stories and Lessons to Transform Learning

    ERIC Educational Resources Information Center

    Lent, ReLeah Cossett; Baca, Jimmy Santiago

    2010-01-01

    Fusing Jimmy Santiago Baca's talents as a writer of memoir with ReLeah Cossett Lent's expertise in building and empowering classroom communities, this book offers a completely new approach to reaching at-risk adolescents. Centered around conflicts and life-altering choices, Baca's gripping personal narratives--delivered through short stories and…

  19. Effects of Social Supports on the Career Choice Consideration of Chinese Farmers: A Social Cognitive Perspective

    ERIC Educational Resources Information Center

    Zhao, Li

    2012-01-01

    Drawing from social cognitive career theory (Lent, Brown, & Hackett, 1994), this study explored social supports' influence on the career choice consideration of farmers during China's current process of urbanization. A questionnaire was designed based on interviews with 140 people and a pretest with a sample of 419 participants. A total of 628…

  20. The Development and Initial Validation of Social Cognitive Career Theory Instruments to Measure Choice of Medical Specialty and Practice Location

    ERIC Educational Resources Information Center

    Rogers, Mary E.; Creed, Peter A.; Searle, Judy

    2009-01-01

    Social cognitive career theory served as the basis for the instrument development for scales assessing self-efficacy, outcome expectations, and goals to predict medical career choice. Lent and Brown's conceptualization of social cognitive constructs guided the development of items to measure choice of medical specialty and practice location. Study…

  1. Vocational Interests and Career Efficacy Expectations in Relation to Occupational Sex-Typing Beliefs for Eighth Grade Students

    ERIC Educational Resources Information Center

    Ji, Peter Y.; Lapan, Richard T.; Tate, Kevin

    2004-01-01

    Following the recommendations of Lent, Brown and Hackett's Social Cognitive Career Theory (2000), we measured eighth grade boys' and girls' perception of the proportion of men and women employed in occupations and their level of interest and self-efficacy for those occupations. Results indicated that eighth grade boys and girls expressed stronger…

  2. A Longitudinal Examination of the Social-Cognitive Model Applied to High School Girls' Choices of Nontraditional College Majors and Aspirations

    ERIC Educational Resources Information Center

    Nauta, Margaret M.; Epperson, Douglas L.

    2003-01-01

    This study tested a partial version of R. W. Lent, S. D. Brown, and G. Hackett's (1994) social-cognitive career theory model. Among 204 high school girls who attended science, math, and engineering (SME) career conferences, the authors used a 4-year longitudinal design to predict the choice of an SME college major and SME self-efficacy and outcome…

  3. The Impact of Life Role Salience on Life Satisfaction

    ERIC Educational Resources Information Center

    Perrone, Kristin M.; Civiletto, Christine L.

    2004-01-01

    The authors examined the relationships among life role salience, role strain, coping efficacy, and life satisfaction for adults (N = 125) who combine multiple life roles. Causal modeling procedures were used to test hypotheses based on D. E. Super's (1980, 1990) life-span, life-space theory and the social cognitive career theory (R. W. Lent, S. D.…

  4. Applying Social Cognitive Career Theory to Predict Interests and Choice Goals in Statistics among Spanish Psychology Students

    ERIC Educational Resources Information Center

    Blanco, Angeles

    2011-01-01

    This study investigated the usefulness of social cognitive career theory--SCCT (Lent, Brown, and Hackett, 1994) in predicting interests and goals relating to statistics among psychology students. The participants were 1036 Spanish students who completed measurements of statistics-related mastery experiences, self-efficacy, outcome expectations,…

  5. A Longitudinal Examination of Adolescent Career Planning and Exploration Using a Social Cognitive Career Theory Framework

    ERIC Educational Resources Information Center

    Rogers, Mary E.; Creed, Peter A.

    2011-01-01

    This study used social cognitive career theory (Lent, Brown, & Hackett, 1994), as a framework to investigate predictors of career choice actions, operationalised as career planning and career exploration. The model was tested cross-sectionally and longitudinally with 631 high school students enrolled in Grades 10-12. Students completed measures of…

  6. Pick a Pair. Pancake Pairs

    ERIC Educational Resources Information Center

    Miller, Pat

    2005-01-01

    Cold February weather and pancakes are a traditional pairing. Pancake Day began as a way to eat up the foods that were abstained from in Lent--traditionally meat, fat, eggs and dairy products. The best-known pancake event is The Pancake Day Race in Buckinghamshire, England, which has been run since 1445. This column describes pairs of books that…

  7. Game-Based Learning: How to Delight and Instruct in The 21st Century

    ERIC Educational Resources Information Center

    Foreman, Joel

    2004-01-01

    Not long after he completed his Ph.D. at the University of Michigan, Mike Van Lent used his interest in videogames and artificial intelligence to land a research professorship at the University of Southern California (USC). There he edits the Journal of Game Development and conducts studies for the Institute for Creative Technologies, a $45…

  8. Teaching Petrarchan and Anti-Petrarchan Discourses in Early Modern English Lyrics

    ERIC Educational Resources Information Center

    Ribes, Purificación

    2012-01-01

    The aim of the present article is to help students realize that Petrarchism has been an influential source of inspiration for Early Modern English lyrics. Its topics and conventions have lent themselves to a wide variety of appropriations which the present selection of texts for analysis tries to illustrate. A few telling examples from Spenser,…

  9. In the Company of Critical Thinkers

    ERIC Educational Resources Information Center

    Lent, ReLeah

    2006-01-01

    What if we could truly engage high schools students in learning by actively involving them in research and discussion leading to concrete actions on issues that interest them? Lent describes her experiences working with student study groups composed of high school students and teachers or adult community members. Study groups differ from…

  10. Mexican American Middle School Students' Goal Intentions in Mathematics and Science: A Test of Social Cognitive Career Theory

    ERIC Educational Resources Information Center

    Navarro, Rachel L.; Flores, Lisa Y.; Worthington, Robert L.

    2007-01-01

    This study examined whether sociocontextual and sociocognitive variables explained the math/science goals of 409 Mexican American youth using a modified version of R. W. Lent, S. D. Brown, and G. Hackett's (1994) social cognitive career theory. Results from structural equation modeling indicated that the hypothesized model explained a significant…

  11. Predicting the Math/Science Career Goals of Low-Income Prospective First-Generation College Students

    ERIC Educational Resources Information Center

    Garriott, Patton O.; Flores, Lisa Y.; Martens, Matthew P.

    2013-01-01

    The present study used social cognitive career theory (SCCT; Lent, Brown, & Hackett, 1994) to predict the math/science goal intentions of a sample of low-income prospective first-generation college students (N = 305). Structural equation modeling was used to test a model depicting relationships between contextual (i.e., social class, learning…

  12. Math and Science Social Cognitive Variables in College Students: Contributions of Contextual Factors in Predicting Goals

    ERIC Educational Resources Information Center

    Byars-Winston, Angela M.; Fouad, Nadya A.

    2008-01-01

    This study investigated the influence of two contextual factors, parental involvement and perceived career barriers, on math/science goals. Using social cognitive career theory (SCCT; Lent, Brown, & Hackett, 1994), a path model was tested to investigate hypothesized relationships between math- and science-related efficacy beliefs (i.e., task and…

  13. Desirability of Personality Dimensions: Auto- and Heteroperceptions by American and German College Students

    ERIC Educational Resources Information Center

    Crott, Helmut W.; Baltes, Paul B.

    1973-01-01

    The results of this study seem to support the usefulness of desirability judgments and personality items as vehicles for intercultural research. Findings lent support to the suggestion that the German student population has been subjected to marked cultural or generational change with regard to evaluative aspects of core personality dimensions.…

  14. Career Counseling as an Environmental Support: Exploring Influences on Career Choice, Career Decision-Making Self-Efficacy, and Career Barriers

    ERIC Educational Resources Information Center

    Makela, Julia Panke

    2011-01-01

    This study was motivated by concerns regarding the difficult academic and career choices facing today's college students as they navigate higher education and encounter career barriers along their paths. Using Social Cognitive Career Theory (SCCT; Lent, Brown, & Hackett, 1994) as a primary framework, the study sought to understand the role that…

  15. Relation of Social-Cognitive Factors to Academic Satisfaction in Engineering Students

    ERIC Educational Resources Information Center

    Lent, Robert W.; Singley, Daniel; Sheu, Hung-Bin; Schmidt, Janet A.; Schmidt, Linda C.

    2007-01-01

    Lent (2004) posited a model of domain-specific and overall life satisfaction in which social-cognitive variables (self-efficacy, outcome expectations, environmental supports, and perceived goal progress) play key roles. In this study, the authors examined the relation of these variables to academic satisfaction. Participants were 153 engineering…

  16. Racial Ideology in Predicting Social Cognitive Career Variables for Black Undergraduates

    ERIC Educational Resources Information Center

    Byars-Winston, Angela M.

    2006-01-01

    This exploratory study expanded Social Cognitive Career Theory (SCCT; Lent, Brown, & Hackett, 1994) by incorporating the personal variable of racial ideology (Sellers, Rowley, Chavous, Shelton, & Smith, 1997). The association of racial ideology (i.e., nationalist, humanist, assimilationist, and oppressed minority) to self-efficacy variables,…

  17. Social Cognitive and Cultural Orientation Predictors of Well-Being in Asian American College Students

    ERIC Educational Resources Information Center

    Hui, Kayi; Lent, Robert W.; Miller, Matthew J.

    2013-01-01

    This study examined the predictive utility of Lent and Brown's social cognitive model of educational and work well-being with a sample of Asian American college students, indexing well-being in terms of academic and social domain satisfaction. In addition, we examined the role of acculturation and enculturation as culture-specific predictors…

  18. The acquisition process of musical tonal schema: implications from connectionist modeling

    PubMed Central

    Matsunaga, Rie; Hartono, Pitoyo; Abe, Jun-ichi

    2015-01-01

    Using connectionist modeling, we address fundamental questions concerning the acquisition process of musical tonal schema of listeners. Compared to models of previous studies, our connectionist model (Learning Network for Tonal Schema, LeNTS) was better equipped to fulfill three basic requirements. Specifically, LeNTS was equipped with a learning mechanism, bound by culture-general properties, and trained by sufficient melody materials. When exposed to Western music, LeNTS acquired musical ‘scale’ sensitivity early and ‘harmony’ sensitivity later. The order of acquisition of scale and harmony sensitivities shown by LeNTS was consistent with the culture-specific acquisition order shown by musically westernized children. The implications of these results for the acquisition process of a tonal schema of listeners are as follows: (a) the acquisition process may entail small and incremental changes, rather than large and stage-like changes, in corresponding neural circuits; (b) the speed of schema acquisition may mainly depend on musical experiences rather than maturation; and (c) the learning principles of schema acquisition may be culturally invariant while the acquired tonal schemas are varied with exposed culture-specific music. PMID:26441725

  19. Evidence of an Adaptive Level Grading Practice through a Causal Approach.

    ERIC Educational Resources Information Center

    Gallini, Joan

    1982-01-01

    The adaptation level theory in grading implies that students select major programs whose grading practices are realistic with their ability. A causal approach using a system of multiple equations was used to investigate this theory. The results lent support to occurrence of the adaptive grading practice. (Author/CM)

  20. Freshman Engineering Students At-Risk of Non-Matriculation: Self-Efficacy for Academic Learning

    ERIC Educational Resources Information Center

    Ernst, Jeremy V.; Bowen, Bradley D.; Williams, Thomas O.

    2016-01-01

    Students identified as at-risk of non-academic continuation have a propensity toward lower academic self-efficacy than their peers (Lent, 2005). Within engineering, self-efficacy and confidence are major markers of university continuation and success (Lourens, 2014 Raelin, et al., 2014). This study explored academic learning self-efficacy specific…

  1. Do Personality Traits Contribute to Vocational Self-Efficacy?

    ERIC Educational Resources Information Center

    Larson, Lisa M.; Borgen, Fred H.

    2006-01-01

    Although personality is viewed as a precursor to self-efficacy and interest development (e.g., Lent, Brown, & Hackett, 1994), little research concerns linkages between personality and self-efficacy. This article bridges the relation by presenting the pattern of findings across four university samples. Three general and 11 specific personality…

  2. Evaluating the Student Loan Fund of Thailand

    ERIC Educational Resources Information Center

    Tangkitvanich, Somkiat; Manasboonphempool, Areeya

    2010-01-01

    The Thai higher education sector has expanded quickly during the past decade, making a transition from an elitist to a mass institution. A driving force behind the expansion was believed to be the Student Loan Fund (SLF), introduced in 1996. During the first 10 years of its operation, the SLF has lent to more than 2.6 million students, with the…

  3. Prospective First-Generation College Students: A Social-Cognitive Perspective

    ERIC Educational Resources Information Center

    Gibbons, Melinda M.; Borders, L. DiAnne

    2010-01-01

    The authors investigated differences in college-going expectations of middle school students who would be the 1st in their families to attend college. Social-cognitive career theory (SCCT; R. W. Lent, S. D. Brown, & G. Hackett, 1994) was used to examine college-related expectations in 272 seventh-grade students. Differences were found between…

  4. Examining a Model of Life Satisfaction among Unemployed Adults

    ERIC Educational Resources Information Center

    Duffy, Ryan D.; Bott, Elizabeth M.; Allan, Blake A.; Torrey, Carrie L.

    2013-01-01

    The present study examined a model of life satisfaction among a diverse sample of 184 adults who had been unemployed for an average of 10.60 months. Using the Lent (2004) model of life satisfaction as a framework, a model was tested with 5 hypothesized predictor variables: optimism, job search self-efficacy, job search support, job search…

  5. Fitting the Bill: Commissioned Theatre Projects on Human Rights in Pakistan--The Work of Karachi-Based Theatre Group "Tehrik e Niswan"

    ERIC Educational Resources Information Center

    Mundrawala, Asma

    2007-01-01

    Theatre practitioners in Pakistan's southern city Karachi have seen a recent surge of interest in the past two decades by donor agencies from the Western world to fund theatre companies and employ various forms of theatre for development to service their agendas and areas of interest within their target communities. This trend may have lent a…

  6. Attending to Place, Race, and Community: Trans-Local Partnering between Scholars and Activists in Central Appalachia and the Black Belt South

    ERIC Educational Resources Information Center

    Harris, Rosalind; Bernard, Marcus; Mullinax, Maureen; Worthen, Dreamal; Finch, Sokoya; Womack, Veronica

    2012-01-01

    The communities in the Black Belt South and Central Appalachian regions in the United States share long histories of persistent subjugation. Both regions also have strong traditions of partnerships between grassroots activists and scholars--partnerships that have, at times, lent resilient responses to political, economic and cultural challenges,…

  7. 12 CFR 208.100 - Sale of bank's money orders off premises as establishment of branch office.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Sale of bank's money orders off premises as... SYSTEM (REGULATION H) Interpretations § 208.100 Sale of bank's money orders off premises as establishment... deposits are received, or checks paid, or money lent.” The basic question is whether the sale of a...

  8. Two Tests of the Social Cognitive Model of Well-Being in Portuguese College Students

    ERIC Educational Resources Information Center

    Lent, Robert W.; Taveira, Maria do Ceu; Lobo, Cristina

    2012-01-01

    A social cognitive model of well-being (Lent & Brown, 2006, 2008) was tested in two studies (one cross-sectional, one longitudinal) with Portuguese college students. Participants in Study 1 (N = 366) completed measures of academic self-efficacy, environmental support, goal progress, academic satisfaction and stress, trait positive affect, and…

  9. The Career Development of Mexican American Adolescent Women: A Test of Social Cognitive Career Theory

    ERIC Educational Resources Information Center

    Flores, Lisa Y.; O'Brien, Karen M.

    2002-01-01

    This study tested R. W. Lent, S. D. Brown, and G. Hackett's (1994) model of career choice with 364 Mexican American adolescent women. Path analyses were run to determine the influence of contextual and social cognitive variables on career aspiration, career choice prestige, and traditionality. Partial support for the model was evidenced as…

  10. College Students' Social Justice Interest and Commitment: A Social-Cognitive Perspective

    ERIC Educational Resources Information Center

    Miller, Matthew J.; Sendrowitz, Kerrin; Connacher, Christopher; Blanco, Susana; de La Pena, Cristina Muniz; Bernardi, Shaina; Morere, Lauren

    2009-01-01

    In this study, the authors examined the degree to which social-cognitive career theory (SCCT; R. W. Lent, S. D. Brown, & G. Hackett, 1994) explained the development of social justice interest and commitment. Data from 274 college students and latent variable path modeling were used to test theoretically and empirically derived SCCT direct and…

  11. Predicting the Job and Life Satisfaction of Italian Teachers: Test of a Social Cognitive Model

    ERIC Educational Resources Information Center

    Lent, Robert W.; Nota, Laura; Soresi, Salvatore; Ginevra, Maria C.; Duffy, Ryan D.; Brown, Steven D.

    2011-01-01

    This study tested a social cognitive model of work and life satisfaction (Lent & Brown, 2006, 2008) in a sample of 235 Italian school teachers. The model offered good overall fit to the data, though not all individual path coefficients were significant. Three of five predictors (favorable work conditions, efficacy-relevant supports, and…

  12. Social Cognitive Predictors of Mexican American College Students' Academic and Life Satisfaction

    ERIC Educational Resources Information Center

    Ojeda, Lizette; Flores, Lisa Y.; Navarro, Rachel L.

    2011-01-01

    In this study, we used Lent's (2004) social cognitive model of well being to examine the academic and life satisfaction of 457 Mexican American college students attending a Hispanic-Serving Institution. Using structural equation modeling, results indicated that the model provided a good fit to the data. Specifically, we found positive relations…

  13. 12 CFR 211.21 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... permissible for an agency, and engages in the business of making commercial loans. Commercial lending company... means any place of business of a foreign bank, located in any state, at which credit balances are maintained, checks are paid, money is lent, or, to the extent not prohibited by state or federal...

  14. 12 CFR 221.116 - Bank loans to replenish working capital used to purchase mutual fund shares.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... considered by the Board of Governors, a business concern (X) proposed to purchase mutual fund shares, from... to secure working capital. The bank was prepared to lend amounts equal to 70 percent of the current... of the current market value of the shares could be lent. (b) The immediate purpose of the loans...

  15. 12 CFR 9.2 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... which deposits are received, or checks paid, or money lent. (k) Trust representative office means an... activities ancillary to its fiduciary business, but does not engage in any of the activities specified in § 9... business; contacting existing or potential customers, answering questions, and providing information...

  16. 12 CFR 208.110 - Sale of bank's money orders off premises as establishment of branch office.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... bank, branch office, branch agency, additional office, or any branch place of business * * * at which deposits are received, or checks paid, or money lent.” The basic question is whether the sale of a bank's money orders by an agent amounts to the receipt of deposits at a branch place of business within...

  17. The Moral Impotence of Contemporary Experts

    ERIC Educational Resources Information Center

    Filion, Yves R.

    2004-01-01

    Technological growth in developed and developing countries in the 20th century has lent a great deal of importance to scientific reasoning in the management of human affairs. An important outgrowth has been the development of systems thinking to organize the workplace. The business reengineering process and the enterprise resource planning system…

  18. The Revenue Imperative: Finding New Funding Streams in the Face of Budget Cuts

    ERIC Educational Resources Information Center

    Fernandez, Kim

    2011-01-01

    By all accounts, 2010 was a watershed year for community colleges. President Obama touted the role these institutions play in putting Americans back to work, and widespread enrollment increases lent credibility to the notion that students at long last are realizing the benefits of two-year quality and value compared with the higher price of…

  19. Influence of Social Cognitive and Ethnic Variables on Academic Goals of Underrepresented Students in Science and Engineering: A Multiple-Groups Analysis

    ERIC Educational Resources Information Center

    Byars-Winston, Angela; Estrada, Yannine; Howard, Christina; Davis, Dalelia; Zalapa, Juan

    2010-01-01

    In this study we investigated the academic interests and goals of 223 African American, Latino/a, Southeast Asian, and Native American undergraduate students in 2 groups: biological science (BIO) and engineering (ENG) majors. Using social cognitive career theory (Lent, Brown, & Hackett, 1994), we examined the relationships of social cognitive…

  20. Longitudinal Relations of Self-Efficacy to Outcome Expectations, Interests, and Major Choice Goals in Engineering Students

    ERIC Educational Resources Information Center

    Lent, Robert W.; Sheu, Hung-Bin; Singley, Daniel; Schmidt, Janet A.; Schmidt, Linda C.; Gloster, Clay S.

    2008-01-01

    We examined the nature of the temporal relations among the core person variables in the social cognitive model of academic and career choice [Lent, R. W., Brown, S. D., & Hackett, G. (1994). Toward a unifying social cognitive theory of career and academic interest, choice, and performance [Monograph]. "Journal of Vocational Behavior," 45,…

  1. Social Cognitive Career Theory and the Prediction of Interests and Choice Goals in the Computing Disciplines

    ERIC Educational Resources Information Center

    Lent, Robert W.; Lopez, Antonio M., Jr.; Lopez, Frederick G.; Sheu, Hung-Bin

    2008-01-01

    We tested the fit of the social cognitive choice model [Lent, R.W., Brown, S.D., & Hackett, G. (1994). "Toward a unifying social cognitive theory of career and academic interest, choice, and performance [Monograph]." "Journal of Vocational Behavior," 45, 79-122] to the data across gender, educational level, and type of university among students in…

  2. Role of Family Background, Student Behaviors, and School-Related Beliefs in Predicting High School Dropout

    ERIC Educational Resources Information Center

    Parr, Alyssa K.; Bonitz, Verena S.

    2015-01-01

    The authors' purpose was to test a parsimonious model derived from social cognitive career theory (R. W. Lent, S. D. Brown, & G. Hackett, 1994) and expectancy value theory (J. S. Eccles & A. Wigfield, 2002) that integrates groups of variables (demographic background, student behaviors, and school-related beliefs) with the goal of…

  3. Perceived Social Status and Learning Experiences in Social Cognitive Career Theory

    ERIC Educational Resources Information Center

    Thompson, Mindi N.; Dahling, Jason J.

    2012-01-01

    The purpose of this study was to test a model based on Social Cognitive Career Theory (Lent, Brown, & Hackett, 1994) that placed perceived social status as an antecedent of career-related learning experiences, self-efficacy, and outcome expectations. Gender was included in the present model and results indicated that gender related as expected to…

  4. College-Level Choice of Latino High School Students: A Social-Cognitive Approach

    ERIC Educational Resources Information Center

    Gonzalez, Laura M.

    2012-01-01

    Latino students attend 2-year colleges more often than 4-year colleges. This has an impact on the rate of bachelor's degree attainment, because the transfer rate between the 2 levels is low. The author uses national data to identify predictors associated with college-level choice and then uses social-cognitive career theory (Lent, Brown, &…

  5. Social Cognitive Predictors of the Interests and Choices of Computing Majors: Applicability to Underrepresented Students

    ERIC Educational Resources Information Center

    Lent, Robert W.; Lopez, Frederick G.; Sheu, Hung-Bin; Lopez, Antonio M., Jr.

    2011-01-01

    In a replication and extension of earlier research, we examined the explanatory adequacy of the social cognitive choice model (Lent, Brown, & Hackett, 1994) in a sample of 1404 students majoring in a variety of computing disciplines at 23 historically Black and 27 predominantly White universities. Participants completed measures of self-efficacy,…

  6. Career Counseling for Women Preparing to Leave Abusive Relationships: A Social Cognitive Career Theory Approach

    ERIC Educational Resources Information Center

    Wachter Morris, Carrie A.; Shoffner, Marie F.; Newsome, Deborah W.

    2009-01-01

    Career counselors work with people from varied segments of society. For battered women, some of the challenges they face from intimate partner violence may significantly influence their career exploration and decision making. Social cognitive career theory (SCCT; R. W. Lent, S. D. Brown, & G. Hackett, 1994) is a framework that has important…

  7. 20 CFR 416.1103 - What is not income?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... receive on money you have lent is income. Buying on credit is treated as though you were borrowing money and what you purchase this way is not income. (g) Bills paid for you. Payment of your bills by someone... food; the food is in-kind income to you. Similarly, if you buy food on credit and your son later...

  8. 20 CFR 416.1103 - What is not income?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... receive on money you have lent is income. Buying on credit is treated as though you were borrowing money and what you purchase this way is not income. (g) Bills paid for you. Payment of your bills by someone... food; the food is in-kind income to you. Similarly, if you buy food on credit and your son later...

  9. 20 CFR 416.1103 - What is not income?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... receive on money you have lent is income. Buying on credit is treated as though you were borrowing money and what you purchase this way is not income. (g) Bills paid for you. Payment of your bills by someone... food; the food is in-kind income to you. Similarly, if you buy food on credit and your son later...

  10. Modeling College Women's Perceptions of Elite Leadership Positions with Social Cognitive Career Theory

    ERIC Educational Resources Information Center

    Yeagley, Emily E.; Subich, Linda M.; Tokar, David M.

    2010-01-01

    The utility of Social Cognitive Career Theory (SCCT; Lent, Brown, & Hackett, 1994) for predicting college women's interests and goals for positions of elite leadership was examined with 156 undergraduate women at a public university. They completed measures of elite leadership self-efficacy expectations, outcome expectations, interests, and goals.…

  11. Precursors of Learning Experiences in Social Cognitive Career Theory

    ERIC Educational Resources Information Center

    Tokar, David M.; Thompson, Mindi N.; Plaufcan, Melissa R.; Williams, Christine M.

    2007-01-01

    This study extended the research on Social Cognitive Career Theory (SCCT; [Lent, R. W., Brown, S. D., & Hackett, G. (1994). Toward a unifying social cognitive theory of career and academic interest, choice, and performance. "Journal of Vocational Behavior," 45, 79-122]) by examining the contributions of 3 person inputs (personality, gender, and…

  12. Relation of Contextual Supports and Barriers to the Choice Goals of Engineering Majors: A Multigroup Analysis

    ERIC Educational Resources Information Center

    Cardenas, Christine Benitez

    2009-01-01

    The study examined whether sociocontextual and sociocognitive variables explained the choice goals of 339 Racial Ethnic Minority and White engineering undergraduate students using a modified version of Lent et al.'s (1994) social cognitive career theory. Results from structural equation modeling indicated that the hypothesized model did not…

  13. Where Are the Women in Women's Sports? Predictors of Female Athletes' Interest in a Coaching Career

    ERIC Educational Resources Information Center

    Moran-Miller, Kelli; Flores, Lisa Y.

    2011-01-01

    In this study, we used social cognitive career theory (Lent, Brown, & Hackett, 1994) to examine the development of female athletes' career interest in coaching and, specifically, the impact of contextual factors (female coaching role models, working hours, and perceived discrimination) on coaching self-efficacy and outcome expectations.…

  14. Initial Scale Development of the Contextual Support for Post-Secondary Planning Scales

    ERIC Educational Resources Information Center

    Ali, Saba Rasheed; Martens, Jessica Kelly; Button, Christopher; Larma, Nicholas C.

    2011-01-01

    Vocational psychologists and career theorists have articulated the importance of social support in the development of career plans for high school youth. More recently, Lent, Brown, and Hackett carefully articulated the location of contextual supports in the Social Cognitive Career Theory (SCCT) framework. However, there is a paucity of research…

  15. The Ongoing Social Construction of the Counseling for Work and Relationship Perspective

    ERIC Educational Resources Information Center

    Richardson, Mary Sue

    2012-01-01

    This rejoinder to the three reactions papers by Blustein (2012), Byars-Winston (2012), and Lent (2012) focuses first on the issue of what is old and what is new about the counseling for work and relationship perspective. This includes the issue of holism, the influence of contextualism, and the designation of new categories and a new discourse for…

  16. The Development and Validation of an Instrument to Assess Student Attitudes Towards Work.

    ERIC Educational Resources Information Center

    Maguire, Thomas O.; And Others

    1982-01-01

    A 75-item instrument was developed to assess high school students' attitudes toward work. Fifteen scales were derived. Analysis of responses from 1,035 students showed high reliabilities. Group differences based on age, sex, previous work experiences, and vocational ambitions lent support to the validity of the scales. (Author/CM)

  17. Developing Effective Managers.

    ERIC Educational Resources Information Center

    Roberts, T.J.

    In this introductory work, the main principles on which British companies are basing management development programs are presented, and stages in assuring a supply of effective managerial talent are set forth: stages in assuring a supply of effective managerial t"lent are set forth: program planning based on clear objectives and communication;…

  18. Facing the Issues: Challenges, Censorship, and Reflection through Dialogue

    ERIC Educational Resources Information Center

    Lent, ReLeah Cossett

    2008-01-01

    ReLeah Cossett Lent provides practical advice for ensuring that books are kept on shelves and in classrooms for students to read. She outlines steps for creating professional learning communities that engage with censorship issues and prepare schools to deal with book challenges in thoughtful, supportive ways. (Contains 4 figures.)

  19. Career Goals, Preferences, and Support for Students in Psychology

    ERIC Educational Resources Information Center

    Miles, Belva A.

    2013-01-01

    Bandura's (1986) social cognitive theory has been adapted by Lent, Brown, and Hackett (1994) to form social cognitive career theory (SCCT). The theory posits three interlocking steps in academic and career development: interest, choice goal, and choice goal action. Self-efficacy, outcome expectations, barriers, and supports are hypothesized to…

  20. Integrating Person and Situation Perspectives on Work Satisfaction: A Social-Cognitive View

    ERIC Educational Resources Information Center

    Lent, Robert W.; Brown, Steven D.

    2006-01-01

    Social cognitive career theory (Lent, Brown, & Hackett, 1994) was originally designed to help explain interest development, choice, and performance in career and educational domains. These three aspects of career/academic development were presented in distinct but overlapping segmental models. This article presents a fourth social cognitive model…

  1. Family Quality of Life Empowered by Family-Oriented Support

    ERIC Educational Resources Information Center

    Schippers, Alice; van Boheemen, Marleen

    2009-01-01

    Professional services for persons with intellectual disabilities (ID) have begun to attach more importance to their environment. The concept of (family-related) quality of life proved to link very well with this idea and lent itself to constructing and evaluating services. One outcome was the emergence of equal partnerships between families,…

  2. Relationships between College Knowledge and College-Going Beliefs of Eighth Grade Students

    ERIC Educational Resources Information Center

    Wisely, Lynn Woodward

    2013-01-01

    This study examined the relationships of college knowledge and parent education level with these college-going beliefs: (a) self-efficacy, (b) outcome expectations, (c) likelihood both to go to and graduate from college, (d) choice intentions, and (e) educational goals. Social Cognitive Career Theory (Lent, Brown, & Hackett, 1994) provided the…

  3. Social Cognitive Career Theory, Conscientiousness, and Work Performance: A Meta-Analytic Path Analysis

    ERIC Educational Resources Information Center

    Brown, Steven D.; Lent, Robert W.; Telander, Kyle; Tramayne, Selena

    2011-01-01

    We performed a meta-analytic path analysis of an abbreviated version of social cognitive career theory's (SCCT) model of work performance (Lent, Brown, & Hackett, 1994). The model we tested included the central cognitive predictors of performance (ability, self-efficacy, performance goals), with the exception of outcome expectations. Results…

  4. Feeling the Threat: Stereotype Threat as a Contextual Barrier to Women's Science Career Choice Intentions

    ERIC Educational Resources Information Center

    Deemer, Eric D.; Thoman, Dustin B.; Chase, Justin P.; Smith, Jessi L.

    2014-01-01

    Social cognitive career theory (SCCT; Lent, Brown, & Hackett, 1994, 2000) holds that contextual barriers inhibit self-efficacy and goal choice intentions from points both near and far from the active career development situation. The current study examined the influence of one such proximal barrier, stereotype threat, on attainment of these…

  5. High order aberration and straylight evaluation after cataract surgery with implantation of an aspheric, aberration correcting monofocal intraocular lens

    PubMed Central

    Kretz, Florian T A; Tandogan, Tamer; Khoramnia, Ramin; Auffarth, Gerd U

    2015-01-01

    AIM To evaluate the quality of vision in respect to high order aberrations and straylight perception after implantation of an aspheric, aberration correcting, monofocal intraocular lens (IOL). METHODS Twenty-one patients (34 eyes) aged 50 to 83y underwent cataract surgery with implantation of an aspheric, aberration correcting IOL (Tecnis ZCB00, Abbott Medical Optics). Three months after surgery they were examined for uncorrected (UDVA) and corrected distance visual acuity (CDVA), contrast sensitivity (CS) under photopic and mesopic conditions with and without glare source, ocular high order aberrations (HOA, Zywave II) and retinal straylight (C-Quant). RESULTS Postoperatively, patients achieved a postoperative CDVA of 0.0 logMAR or better in 97.1% of eyes. Mean values of high order abberations were +0.02±0.27 (primary coma components) and -0.04±0.16 (spherical aberration term). Straylight values of the C-Quant were 1.35±0.44 log which is within normal range of age matched phakic patients. The CS measurements under mesopic and photopic conditions in combination with and without glare did not show any statistical significance in the patient group observed (P≥0.28). CONCLUSION The implantation of an aspherical aberration correcting monofocal IOL after cataract surgery resulted in very low residual higher order aberration (HOA) and normal straylight. PMID:26309872

  6. Interaction of intraocular lenses with fibronectin and human lens epithelial cells: Effect of chemical composition and aging.

    PubMed

    Tortolano, Lionel; Serrano, Carole; Jubeli, Emile; Saunier, Johanna; Yagoubi, Najet

    2015-12-01

    The aim of this study is to investigate in vitro interactions between hydrophobic acrylate intraocular lenses (IOLs) and their biological environment. The influence of lens chemical composition and aging on fibronectin (FN) adsorption and on IOLs cytotoxicity on human lens epithelial cells was examined. Cytotoxicity of acrylate monomers used in IOLs manufacture was also investigated. Four different IOLs were included in the study: Acrysof(®), Tecnis(®), EnVista(®), and iSert(®). Implants were artificially aged in a xenon arc chamber to simulate 2 years of light exposure. Fibronectin adsorption on IOL surface was quantified using ELISA and correlated to surface roughness determined with AFM. Direct contact cytotoxicity was determined with the MTT assay and cell morphology was observed with light microscopy. Results showed that fibronectin adsorption did not differ significantly among IOLs, whatever their chemical composition. Moreover, aging conditions did not impact fibronectin adsorption. All IOLs were biocompatible even after applying 2-year aging conditions, with cell viability higher than 70%. Five acrylate monomers appeared to be toxic in the range of concentrations tested, but no monomer release from the IOLs could be detected during accelerated 2-year incubation with saline solution. This study did not reveal an influence of chemical composition and aging on protein adsorption and on biocompatibility.

  7. Toric intraocular lenses for correction of astigmatism in keratoconus and after corneal surgery

    PubMed Central

    Mol, Ilse EMA; Van Dooren, Bart TH

    2016-01-01

    Purpose To describe the results of cataract extraction with toric intraocular lens (IOL) implantation in patients with preexisting astigmatism from three corneal conditions (keratoconus, postkeratoplasty, and postpterygium surgery). Methods Cataract patients with topographically stable, fairly regular (although sometimes very high) corneal astigmatism underwent phacoemulsification with implantation of a toric IOL (Zeiss AT TORBI 709, Alcon Acrysof IQ toric SN6AT, AMO Tecnis ZCT). Postoperative astigmatism and refractive outcomes, as well as visual acuities, vector reduction, and complications were recorded for all eyes. Results This study evaluated 17 eyes of 16 patients with a mean age of 60 years at the time of surgery. Mean follow-up in this study was 12 months. The corrected distance Snellen visual acuity (with spectacles or contact lenses) 12 months postoperatively was 20/32 or better in 82% of eyes. The mean corneal astigmatism was 6.7 diopters (D) preoperatively, and 1.5 D of refractive cylinder at 1-year follow-up. No vision-compromising intra- or postoperative complications occurred and decentration or off-axis alignment of toric IOLs were not observed. Conclusion Phacoemulsification with toric IOL implantation was a safe and effective procedure in the three mentioned corneal conditions. Patient selection, counseling, and IOL placement with optimal astigmatism correction are crucial. PMID:27382249

  8. Comparison of pseudophakic retinal straylight in spherical/aspherical and hydrophobic/hydrophilic intraocular lens

    PubMed Central

    Tang, Yong; Song, Hui; Chen, Jing; Tang, Xin

    2015-01-01

    AIM To study the potential reasons of increased straylight in pseudophakic eyes. METHODS Cross-sectional study. Seventy patients diagnosed as bilateral age-related cataract and implanted with Tecnis ZA9003, Sensar AR40e, SA60AT, XLSTABI ZO or Akeros AO intraocular lens (IOL) were enrolled in this research. Straylight was measured by a C-Quant straylight meter three to four weeks postoperatively. Five different modalities of IOL, including spherical/aspherical optics and hydrophobic/hydrophilic material were tested in this study. Normal as well as dilated pupils were used. The main outcome variable for straylight measurement was the logarithmic straylight parameter, log(s). RESULTS The straylight parameter increased significantly after pupil dilation (P<0.05). Straylight of aspherical IOL was significantly higher after pupil dilation (P<0.05) compared to spherical IOL. In normal pupil, straylight of hydrophobic IOL was significant higher when compared with hydrophilic IOL (P<0.05). CONCLUSION Straylight and visual acuity stand for the different aspects of visual function. Several factors including pupil diameter, optic material, aspherical design of IOL influence intraocular light scattering in pseudophakic eyes. Further investigation was needed to study the impact of optic material and optic surface design on pseudophakic straylight. PMID:26682163

  9. New Directions for Early Literacy in a Digital Age: The iPad

    ERIC Educational Resources Information Center

    Flewitt, Rosie; Messer, David; Kucirkova, Natalia

    2015-01-01

    In this paper, we discuss how iPads offer innovative opportunities for early literacy learning but also present challenges for teachers and children. We lent iPads to a Children's Centre nursery (3- to 4-year-olds), a primary school reception class (4- to 5-year-olds) and a Special School (7- to 13-year-olds), discussed their potential uses with…

  10. Parhadjelia cairinae n. sp. (Nematoda: Habronematoidea: Habronematidae) in the Muscovy duck, Cairina moschata (Linnaeus, 1758) (Aves: Anseriformes: Anatidae), from the area de conservacion Guanacaste, Costa Rica.

    PubMed

    Zhang, Luping; Brooks, Daniel R

    2005-04-01

    A new species of Parahadjelia occurs in the muscovy duck, Cairina moschata (Linnaeus, 1758), from the Area de Conservacion Guanacaste, Costa Rica. The new species differs from Parhadjelia neglecta Lent and Freitas, 1939, in the body size, in the spicules shape and ratio of spicules, and in having 2 pairs of sessile papillae near the tail tip of the male. The characters exhibited by P. neglecta and the new species validate its generic status distinct from Hadjelia.

  11. Frosch Awarded Goddard Memorial Trophy

    NASA Technical Reports Server (NTRS)

    1980-01-01

    Former President Jimmy Carter presents the National Space Club's Goddard Memorial Trophy to NASA Administrator Dr. Robert A. Frosch on behalf of the team that planned and executed the Voyager mission to Jupiter and beyond. The trophy is America's most prestigious space award, presented annually to an individual or group for outstanding acheivement in space, contributing to U.S. leadership in astronautics. From left to right: John Lent, Martin Marietta Company President Jimmy Carter NASA Administrator Robert A. Frosch

  12. Rediscovery and New Morphological Data on Two Hassalstrongylus (Nematoda: Heligmonellidae) Coparasitic in the Marsh Rat Holochilus chacarius (Rodentia: Cricetidae) from Argentina.

    PubMed

    Digiani, María Celina; Notarnicola, Juliana; Navone, Graciela T

    2015-10-01

    Two species of Hassalstrongylus Durette-Desset, 1971, coparasitic in Holochilus chacarius Thomas (Rodentia, Cricetidae) and not recorded since their original description in 1937, were newly found in their type host and locality. Hassalstrongylus mazzai (Freitas, Lent and Almeida, 1937) and Hassalstrongylus argentinus (Freitas, Lent and Almeida, 1937) were obtained from Ho. chacarius from 2 different populations: one from Salta Province (northwest Argentina) and another from Chaco Province (northeast Argentina). The species described as Heligmonoides mazzai Freitas, Lent and Almeida, 1937 had been transferred to Hassalstrongylus even though its synlophe had never been studied. We provide the first descriptions and illustrations of the synlophe of males and females of Hassalstrongylus mazzai and the female of H. argentinus and account for morphological and metrical variability. We confirm, through the study of the synlophe, the placement of Hassalstrongylus mazzai in the genus Hassalstrongylus and designate neotypes for the species because the type material deposited by the authors could not be found. Females of both species were morphologically very similar, and a principal components analysis (PCA) performed on some morphometrical characters showed that the body length, uterus length, and an unexpected character as the number of eggs were useful characters in the discrimination of both species.

  13. Rediscovery and New Morphological Data on Two Hassalstrongylus (Nematoda: Heligmonellidae) Coparasitic in the Marsh Rat Holochilus chacarius (Rodentia: Cricetidae) from Argentina.

    PubMed

    Digiani, María Celina; Notarnicola, Juliana; Navone, Graciela T

    2015-10-01

    Two species of Hassalstrongylus Durette-Desset, 1971, coparasitic in Holochilus chacarius Thomas (Rodentia, Cricetidae) and not recorded since their original description in 1937, were newly found in their type host and locality. Hassalstrongylus mazzai (Freitas, Lent and Almeida, 1937) and Hassalstrongylus argentinus (Freitas, Lent and Almeida, 1937) were obtained from Ho. chacarius from 2 different populations: one from Salta Province (northwest Argentina) and another from Chaco Province (northeast Argentina). The species described as Heligmonoides mazzai Freitas, Lent and Almeida, 1937 had been transferred to Hassalstrongylus even though its synlophe had never been studied. We provide the first descriptions and illustrations of the synlophe of males and females of Hassalstrongylus mazzai and the female of H. argentinus and account for morphological and metrical variability. We confirm, through the study of the synlophe, the placement of Hassalstrongylus mazzai in the genus Hassalstrongylus and designate neotypes for the species because the type material deposited by the authors could not be found. Females of both species were morphologically very similar, and a principal components analysis (PCA) performed on some morphometrical characters showed that the body length, uterus length, and an unexpected character as the number of eggs were useful characters in the discrimination of both species. PMID:26193068

  14. Comparison of Through-Focus Image Quality Across Five Presbyopia-Correcting Intraocular Lenses (An American Ophthalmological Society Thesis)

    PubMed Central

    Pepose, Jay S.; Wang, Daozhi; Altmann, Griffith E.

    2011-01-01

    Purpose To assess through-focus polychromatic image sharpness of five US Food and Drug Administration–approved presbyopia-correcting intraocular lenses (IOLs) through a range of object vergences and pupil diameters utilizing an image sharpness algorithm. Methods A 1951 US Air Force resolution target was imaged through a Crystalens AO (AO) (Bausch & Lomb Surgical, Aliso Viejo, California), Crystalens HD (HD) (Bausch & Lomb Surgical, Aliso Viejo, California), aspheric ReSTOR +4.0 (R4) (Alcon Laboratories, Fort Worth, Texas), aspheric ReSTOR +3.0 (R3) (Alcon Laboratories, Fort Worth, Texas), and Tecnis Multifocal Acrylic (TMF) (Abbott Medical Optics, Irvine, California) IOL in an anatomically and optically accurate model eye and captured digitally for each combination of pupil diameter and object vergence. The sharpness of each digital image was objectively scored using a two-dimensional gradient function. Results The AO lens had the best distance image sharpness for all pupil diameters, followed by the HD. With a 5-mm pupil, the R4 lens achieved distance image quality similar to the HD, but inferior to the AO. The R3 successfully moved the near focal point farther from the patient compared to the R4, but did not improve image sharpness at intermediate distances and showed worse distance and near image sharpness. Consistent with apodization, the ReSTOR IOLs displayed better distance and poorer near image sharpness as pupil diameter increased. The TMF lens showed consistent distance and near image sharpness across pupil diameters and exhibited the best near image sharpness for all pupil diameters. Conclusions Differing IOL design strategies to increase depth of field are associated with quantifiable differences in image sharpness at varying vergences and pupil sizes. An objective comparison of the imaging properties of specific presbyopia-correcting IOLs, in conjunction with patients’ pupil sizes, can be useful in selecting the most appropriate IOL for each patient

  15. Espectroscopia multi-objeto e imageamento de Abell 586 com GMOS - o estado dinâmico de um aglomerado de galáxias com arcos gravitacionais

    NASA Astrophysics Data System (ADS)

    Cypriano, E. S.; Sodrã©, L., Jr.; Kneib, J.-P.; Campusano, L.

    2003-08-01

    Nesse trabalho é apresentado um estudo do conteúdo de massa do aglomerado de galáxias A586 (z = 0.171) bem como sua distribuição espacial. Isso foi feito a partir de dados de espectroscopia multi-objeto e imageamento obtidos com o instrumento GMOS acoplado ao telescópio Gemini-Norte. A massa desse aglomerado foi estudada a partir da posição dos seus arcos gravitacionais (lentes fortes), da medida estatística da distorção na forma das galáxias de fundo (lentes fracas) e através da dispersão de velocidades de uma amostra de cerca de 30 galáxias pertencentes ao aglomerado (teorema do virial). Os dois primeiros métodos não dependem do estado dinâmico do aglomerado, enquanto que o terceiro sim. Desse modo, comparando seus resultados pode-se estimar o grau de relaxamento desse sistema. Dados de raios X presentes na literatura também serão incluídos nessa análise. Nossos resultados preliminares a partir das técnicas de lentes fracas, mostram que, supondo que a distribuição de massa desse aglomerado seja a de uma esfera isotérmica, espera-se que ele apresente uma dispersão de velocidades de 1330+/-78 km s-1, em contradicao com medidas similares feitas por Dahle et al. 2002 que encontram valores tão altos quanto 1680 km s-1. Já o estudo dinâmico resultou numa dispersão de velocidades de ~950 km s-1.

  16. Protection of Salivary Function by Concomitant Pilocarpine During Radiotherapy: A Double-Blind, Randomized, Placebo-Controlled Study

    SciTech Connect

    Burlage, Fred R. Roesink, Judith M.; Kampinga, Harm H.; Coppes, Rob P.; Terhaard, Chris; Langendijk, Johannes A.; Luijk, Peter van; Stokman, Monique A.; Vissink, Arjan

    2008-01-01

    Purpose: To investigate the effect of concomitant administration of pilocarpine during radiotherapy for head-and-neck squamous cell carcinoma (HNSCC) on postradiotherapy xerostomia. Methods and Materials: A prospective, double blind, placebo-controlled randomized trial including 170 patients with HNSCC was executed to study the protective effect of pilocarpine on radiotherapy-induced parotid gland dysfunction. The primary objective endpoint was parotid flow rate complication probability (PFCP) scored 6 weeks, 6 months, and 12 months after radiotherapy. Secondary endpoints included Late Effects of Normal Tissue/Somatic Objective Management Analytic scale (LENT SOMA) and patient-rated xerostomia scores. For all parotid glands, dose-volume histograms were assessed because the dose distribution in the parotid glands is considered the most important prognostic factor with regard to radiation-induced salivary dysfunction. Results: Although no significant differences in PFCP were found for the two treatments arms, a significant (p = 0.03) reduced loss of parotid flow 1 year after radiotherapy was observed in those patients who received pilocarpine and a mean parotid dose above 40 Gy. The LENT SOMA and patient-rated xerostomia scores showed similar trends toward less dryness-related complaints for the pilocarpine group. Conclusions: Concomitant administration of pilocarpine during radiotherapy did not improve the PFCP or LENT SOMA and patient-rated xerostomia scores. In a subgroup of patients with a mean dose above 40 Gy, pilocarpine administration resulted in sparing of parotid gland function. Therefore, pilocarpine could be provided to patients in whom sufficient sparing of the parotid is not achievable.

  17. Syringe exchange as a social movement: a case study of harm reduction in Oakland, California.

    PubMed

    Bluthenthal, R N

    1998-04-01

    The federal ban on funding for syringe exchange programs (SEPs) has greatly hampered attempts to prevent the spread of HIV among injection drug users in the United States. State laws prohibiting the possession and/or distribution of syringes have made SEPs illegal. These factors have lent a unique social movement quality to harm reduction efforts in the United States. Using a social movement perspective, this paper explores dynamics of the implementation and defense of the syringe exchange program in Oakland, California. The advantages and disadvantages of the social movement aspects of harm reduction are discussed. PMID:9596381

  18. Lise Meitner and the beta-ray energy controversy: An historical perspective

    NASA Astrophysics Data System (ADS)

    Watkins, Sallie A.

    1983-06-01

    Much has been written about the early history of beta-ray research and the controversy it provoked. Many prominent physicists lent their talents to the solution of this puzzling problem. One of the foremost of these was Lise Meitner, conspicuous in the fray not only because of her creative experimental work, but also because of her attachment to a physical principle—the simplicity of nature. This article reviews the sequence of events as they preceded, coincided with, and followed her work on the subject.

  19. Lise Meitner and the beta-ray energy controversy: An historical perspective

    SciTech Connect

    Watkins, S.A.

    1983-06-01

    Much has been written about the early history of beta-ray research and the controversy it provoked. Many prominent physicists lent their talents to the solution of this puzzling problem. One of the foremost of these was Lise Meitner, conspicuous in the fray not only because of her creative experimental work, but also because of her attachment to a physical principle: the simplicity of nature. This article reviews the sequence of events as they preceded, coincided with, and followed her work on the subject.

  20. Developing a Vision: Incorporating Ecosystem Services into Decision Making - Proceedings of a Workshop

    USGS Publications Warehouse

    Hogan, Dianna; Arthaud, Greg; Goodman, Iris; Pattison, Malka; Sayre, Roger G.; Shapiro, Carl; Van Horne, Bea

    2009-01-01

    The production, location, use, and value of ecosystem services have become an important factor in resource management. Decisions relating to resource conservation and restoration, as well as development, require an understanding of the services provided by natural systems and the response of these systems to natural and human-induced change. Increased demands for development and the resulting pressures on ecosystem services have lent urgency to the need for an improved understanding of the value of natural capital. However, resource management decisions are often made without considering the importance and value of services resulting from natural systems.

  1. Synaptic and non-synaptic mechanisms of amygdala recruitment into temporolimbic epileptiform activities.

    PubMed

    Klueva, Julia; Munsch, Thomas; Albrecht, Doris; Pape, Hans-Christian

    2003-11-01

    Lateral amygdala (LA) activity during synchronized-epileptiform discharges in temporolimbic circuits was investigated in rat horizontal slices containing the amygdala, hippocampus (Hip), perirhinal (Prh) and lateral entorhinal (LEnt) cortex, through multiple-site extra- and intracellular recording techniques and measurement of the extracellular K+ concentration. Application of 4-aminopyridine (50 microm) induced epileptiform discharges in all regions under study. Slow interictal-like burst discharges persisted in the Prh/LEnt/LA after disconnection of the Hip, seemed to originate in the Prh as shown from time delay analyses, and often preceded the onset of ictal-like activity. Disconnection of the amygdala resulted in de-synchronization of epileptiform discharges in the LA from those in the Prh/LEnt. Interictal-like activity was intracellularly reflected in LA projection neurons as gamma-aminobutyric acid (GABA)A/B receptor-mediated synaptic responses, and depolarizing electrogenic events (spikelets) residing on the initial phase of the GABA response. Spikelets were considered antidromically conducted ectopic action potentials generated at axon terminals, as they were graded in amplitude, were not abolished through hyperpolarizing membrane responses (which effectively blocked evoked orthodromic action potentials), lacked a clear prepotential or synaptic potential, were not affected through blockers of gap junctions, and were blocked through remote application of tetrodotoxin at putative target areas of LA projection neurons. Remote application of a GABAB receptor antagonist facilitated spikelet generation. A transient elevation in the extracellular K+ level averaging 3 mm above baseline occurred in conjunction with interictal-like activity in all areas under study. We conclude that interictal-like discharges in the LA/LEnt/Prh spread in a predictable manner through the synaptic network with the Prh playing a leading role. The rise in extracellular K+ may provide a

  2. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2002-09-01

    Jeunes étoiles et vieilles galaxies; Chiens de Chasse; Des images en partie belges; Détection chimique de planètes?; Amas cannibale; Le pulsar œil de bœuf; Supernova 2002 DJ; Centaurus A; Et de cent; Près du trou noir; Un cratère sous la Merdu Nord; Des astéroï des frôlent la Terre; Photons fatigués; Taches solaires; Un grand lac martien; Les naines brunes en infrarouge; Bourrelet équatorial; Fusion de trous noirs; Le hamburger de Gomez; Matière sombre; Non aux étoiles à quarks

  3. Thubunaea dactyluris Sensu Fabio and Rolas, a synonym of Physalopteroides venancioi (Spirurida, Physalopteridae).

    PubMed

    Vrcibradic, D; Vicente, J J; Bursey, C R

    2000-10-01

    Specimens of Thubunaea dactyluris Karve, 1938 sensu Fabio and Rolas, 1974 from the lizard Ameiva ameiva of Brazil and types of Physalopteroides venancioi (Lent, Freitas, and Proença, 1946) from the toad Bufo paracnemis of Paraguay were re-examined. The male caudal papillae and the tooth arrangement demonstrated that these specimens were conspecific and are all assigned to P. venancioi. The occurrence of Physalopteroides dactyluris (Karve, 1938), a nematode parasite of lizards of India and Turkmenistan, is invalidated for Brazil. PMID:11128504

  4. Triatoma jatai sp. nov. in the state of Tocantins, Brazil (Hemiptera: Reduviidae: Triatominae)

    PubMed Central

    Gonçalves, Teresa Cristina Monte; Teves-Neves, Simone Caldas; dos Santos-Mallet, Jacenir Reis; Carbajal-de-la-Fuente, Ana Laura; Lopes, Catarina Macedo

    2013-01-01

    Triatoma jatai sp. nov. is the first new species of triatomine to be described in the state of Tocantins, in the northern region of Brazil. It was caught on rock outcrops in the wild environment and, more recently, invading homes. While T. jatai sp. nov. is morphologically similar to Triatoma costalimai, it is distinguished by its general colouring, differences in the blotches on the connexivum, wing size in females and external structures of the male genitalia. The type series has been deposited in the Entomological Collection and Herman Lent Collection, Oswaldo Cruz Institute-Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. PMID:23828010

  5. Laser cooling of a trapped two-component Fermi gas

    SciTech Connect

    Idziaszek, Z.; Santos, L.; Lewenstein, M.; Baranov, M.

    2003-04-01

    We study the collective Raman cooling of a trapped two-component Fermi gas using quantum master equation in the festina lente regime, where the heating due to photon reabsorption can be neglected. The Monte Carlo simulations show that three-dimensional temperatures of the order of 0.008T{sub F} can be achieved. We analyze the heating related to background losses, and show that our laser-cooling scheme can maintain the temperature of the gas without significant additional losses.

  6. Syringe exchange as a social movement: a case study of harm reduction in Oakland, California.

    PubMed

    Bluthenthal, R N

    1998-04-01

    The federal ban on funding for syringe exchange programs (SEPs) has greatly hampered attempts to prevent the spread of HIV among injection drug users in the United States. State laws prohibiting the possession and/or distribution of syringes have made SEPs illegal. These factors have lent a unique social movement quality to harm reduction efforts in the United States. Using a social movement perspective, this paper explores dynamics of the implementation and defense of the syringe exchange program in Oakland, California. The advantages and disadvantages of the social movement aspects of harm reduction are discussed.

  7. Triatoma jatai sp. nov. in the state of Tocantins, Brazil (Hemiptera: Reduviidae: Triatominae).

    PubMed

    Gonçalves, Teresa Cristina Monte; Teves-Neves, Simone Caldas; Santos-Mallet, Jacenir Reis dos; Carbajal-de-la-Fuente, Ana Laura; Lopes, Catarina Macedo

    2013-06-01

    Triatoma jatai sp. nov. is the first new species of triatomine to be described in the state of Tocantins, in the northern region of Brazil. It was caught on rock outcrops in the wild environment and, more recently, invading homes. While T. jatai sp. nov. is morphologically similar to Triatoma costalimai, it is distinguished by its general colouring, differences in the blotches on the connexivum, wing size in females and external structures of the male genitalia. The type series has been deposited in the Entomological Collection and Herman Lent Collection, Oswaldo Cruz Institute-Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

  8. Is Crohn's disease due to defective immunity?

    PubMed Central

    Korzenik, J R

    2007-01-01

    The understanding of the pathophysiology of Crohn's disease is currently undergoing a reassessment. The concept of this disease as a primary T cell disorder is being questioned, with a new emphasis on the role of innate immunity in initiating early events and in perpetuating the inflammatory state. Crohn's disease has been proposed instead to result from impaired innate immunity, encompassing the mucosal barrier and cellular elements including neutrophils and macrophages. Recent advances in genetics, functional studies on innate immunity and therapeutic trials on patients with Crohn's disease have lent support to this evolving hypothesis. PMID:17172582

  9. Schulzia chiribita n. sp. (Nematoda, Trichostrongylina, Molineoidea) parasite of Leptodactylus rhodonotus (Amphibian) from Peru.

    PubMed

    Durette-Desset, M C; Florindez, D T; Morales, E

    2000-03-01

    A third species of the genus Schulzia Travassos, 1937 a parasite of Leptodactylus rhodonotus (Amphibian, Leptodactylidae) originating from Peru is described. By the pattern of the caudal bursa, the specimens are closely related to the two other species. They are distinguished from Schulzia uzu Lent & Santos, 1989, parasite from Atelopus oxyrhynchus in Venezuela, by the shape of the ovejector and from Schulzia travassosi Durette-Desset, Baker & Vaucher, 1985, parasite from Bufo crucifer in Brasil, Bufo granulosus and Leptodactylus bufonius in Paraguay, by the shape of the spicules. The presence of a new species in Peru points out the wide geographic distribution of the genus in the Neotropical region. PMID:10743644

  10. U.S. POSTDOCS: Report Urges Better Treatment, Status.

    PubMed

    Mervis, J

    2000-09-15

    For years, U.S. postdocs have been complaining about paltry salaries, lack of benefits, and lowly status. This week, a committee of the National Academies of Sciences and Engineering and the Institute of Medicine validated many of their complaints and lent its considerable weight to efforts to provide greater institutional support for postdocs. At the same time, however, the panel sidestepped two burning issues by explicitly declining to recommend a boost in postdoc salaries or take a position on whether to curtail the size of the postdoc workforce, which has more than doubled in the past 20 years to an estimated 52,000.

  11. [Mothers, children, and the policies of Chile's Servicio Nacional de Salud (1952-1964)].

    PubMed

    Zárate Campos, María Soledad; Godoy Catalán, Lorena

    2011-12-01

    This description and exploration of the early years of Servicio Nacional de Salud, founded in 1952, analyzes the agency's progress and challenges, as well as the role of the Programa de Salud Materno-Infantil. The latter program lent continuity to a variety of sanitary protection policies for mothers and children dating to the 1920s, while also improving and expanding on existing policies and devising new ones within the framework of social medicine. The program recorded successes but also encountered limitations, which derived not only from agency-specific problems but also from the social and economic ills afflicting the country as a whole.

  12. Differentiation between Triatoma arthurneivai and Triatoma wygodzinskyi (Hemiptera: Reduviidae: Triatominae) using cytotaxonomy.

    PubMed

    Alevi, K C C; Imperador, C H L; Moreira, F F F; Jurberg, J; Azeredo-Oliveira, M T V

    2016-01-01

    Using classic morphometric techniques to examine the head and thorax of Triatoma specimens, researchers identified a possible taxonomic problem involving T. arthurneivai (Lent & Martins) and T. wygodzinskyi (Lent). A recent geometric morphometric study indicated that the insects captured outside the Serra do Cipó region, State of Minas Gerais, Brazil, were T. wygodzinskyi. The misidentification of T. arthurneivai as T. wygodzinskyi could result in several problems associated with entoepidemiological lifting, the biological characterization of the species, and phylogenetic reconstruction. For the first time, we describe the use of cytogenetic analysis as a tool for differentiation between T. arthurneivai and T. wygodzinskyi. The results indicated that both species had the same number of chromosomes 2n = 22 (20A + XY). However, analyses of spermatocytes during early prophase indicated that it was possible to differentiate T. arthurneivai and T. wygodzinskyi, because only T. arthurneivai exhibited heteropycnotic blocks distributed in the chromatin. Therefore, we highlight the analysis of spermatocytes as a taxonomic tool for the characterization of T. arthurneivai and T. wygodzinskyi, and suggest that the technique can be used for entoepidemiological lifting in vector control programs. Thus, the results presented here, in conjunction with morphometric analyses, are of utmost taxonomic and epidemiological importance for the identification of T. arthurneivai and T. wygodzinskyi specimens. PMID:27420940

  13. Differentiation between Triatoma arthurneivai and Triatoma wygodzinskyi (Hemiptera: Reduviidae: Triatominae) using cytotaxonomy.

    PubMed

    Alevi, K C C; Imperador, C H L; Moreira, F F F; Jurberg, J; Azeredo-Oliveira, M T V

    2016-06-20

    Using classic morphometric techniques to examine the head and thorax of Triatoma specimens, researchers identified a possible taxonomic problem involving T. arthurneivai (Lent & Martins) and T. wygodzinskyi (Lent). A recent geometric morphometric study indicated that the insects captured outside the Serra do Cipó region, State of Minas Gerais, Brazil, were T. wygodzinskyi. The misidentification of T. arthurneivai as T. wygodzinskyi could result in several problems associated with entoepidemiological lifting, the biological characterization of the species, and phylogenetic reconstruction. For the first time, we describe the use of cytogenetic analysis as a tool for differentiation between T. arthurneivai and T. wygodzinskyi. The results indicated that both species had the same number of chromosomes 2n = 22 (20A + XY). However, analyses of spermatocytes during early prophase indicated that it was possible to differentiate T. arthurneivai and T. wygodzinskyi, because only T. arthurneivai exhibited heteropycnotic blocks distributed in the chromatin. Therefore, we highlight the analysis of spermatocytes as a taxonomic tool for the characterization of T. arthurneivai and T. wygodzinskyi, and suggest that the technique can be used for entoepidemiological lifting in vector control programs. Thus, the results presented here, in conjunction with morphometric analyses, are of utmost taxonomic and epidemiological importance for the identification of T. arthurneivai and T. wygodzinskyi specimens.

  14. History of diabetes: from ants to analogs.

    PubMed

    Das, A K; Shah, Siddharth

    2011-04-01

    The earliest description of diabetes was documented in the writings of Hindu scholars as long as in 1500 BC. In 1921 the Canadian scientists Fredrick G. Banting, Charles H. Best, J. J. R. Macleod and James B. Collip discovered insulin, a peptide (small protein hormone) which lowers blood sugar. They extracted insulin from the islets of animal pancreases. A year later, in January 1922, bovine insulin was first given to humans by injection. The co-discoverers, in particular James Collip, continued their work to purify the insulin extract to make it safer and more effective. In 1936, protamine, a low-weight protein, was used to develop a suspension. In 1951 the amorphous 'lente' insulins- semilente, lente and ultralente were developed. After several years of laboratory work during the years 1963-1966 human insulin was chemically synthesized. In 1975, fully synthetic insulin was synthesized. Since 1996, different insulin analogues have been introduced worldwide. Insulin therapy is undergoing a paradigm shift now a days and at this hour we need to focus on the cardinal principles of initiating, optimizing, and intensifying the treatment for achieving adequate control.

  15. Hyperbaric Oxygen Therapy for Radiation-Induced Cystitis and Proctitis

    SciTech Connect

    Oliai, Caspian; Fisher, Brandon; Jani, Ashish; Wong, Michael; Poli, Jaganmohan; Brady, Luther W.; Komarnicky, Lydia T.

    2012-11-01

    Purpose: To provide a retrospective analysis of the efficacy of hyperbaric oxygen therapy (HBOT) for treating hemorrhagic cystitis (HC) and proctitis secondary to pelvic- and prostate-only radiotherapy. Methods and Materials: Nineteen patients were treated with HBOT for radiation-induced HC and proctitis. The median age at treatment was 66 years (range, 15-84 years). The range of external-beam radiation delivered was 50.0-75.6 Gy. Bleeding must have been refractory to other therapies. Patients received 100% oxygen at 2.0 atmospheres absolute pressure for 90-120 min per treatment in a monoplace chamber. Symptoms were retrospectively scored according to the Late Effects of Normal Tissues-Subjective, Objective, Management, Analytic (LENT-SOMA) scale to evaluate short-term efficacy. Recurrence of hematuria/hematochezia was used to assess long-term efficacy. Results: Four of the 19 patients were lost to follow-up. Fifteen patients were evaluated and received a mean of 29.8 dives: 11 developed HC and 4 proctitis. All patients experienced a reduction in their LENT-SOMA score. After completion of HBOT, the mean LENT-SOMA score was reduced from 0.78 to 0.20 in patients with HC and from 0.66 to 0.26 in patients with proctitis. Median follow-up was 39 months (range, 7-70 months). No cases of hematuria were refractory to HBOT. Complete resolution of hematuria was seen in 81% (n = 9) and partial response in 18% (n = 2). Recurrence of hematuria occurred in 36% (n = 4) after a median of 10 months. Complete resolution of hematochezia was seen in 50% (n = 2), partial response in 25% (n = 1), and refractory bleeding in 25% (n = 1). Conclusions: Hyperbaric oxygen therapy is appropriate for radiation-induced HC once less time-consuming therapies have failed to resolve the bleeding. In these conditions, HBOT is efficacious in the short and long term, with minimal side effects.

  16. Angiosarcoma of the liver: an epidemiologic survey.

    PubMed

    Brady, J; Liberatore, F; Harper, P; Greenwald, P; Burnett, W; Davies, J N; Bishop, M; Polan, A; Vianna, N

    1977-11-01

    Diagnosed from 1970 through 1975, the annual incidence rate for angiosarcoma of the liver among residents of New York State (excluding New York City) was 0.25 per million. A case-control study indicated that direct exposure to arsenic, vinyl chloride (VC), and thorium dioxide was a significantly important factor in the etiology of this disorder (P less than 0.02). Direct exposure to these chemicals could not be demonstrated for 19 (73%) of the 26 study patients. The fact that 5 of these patients lived nearer to VC fabrication or polymerization plants than did their matched controls lent some support to the hypothesis that indirect modes of exposure, not specifically related to occupation, might be important in the etiology of this disorder.

  17. Empowering the Community to Manage Diabetes Better: An Integrated Partnership-Based Model

    PubMed Central

    Bamne, Arun; Shah, Daksha; Palkar, Sanjivani; Uppal, Shweta; Majumdar, Anurita; Naik, Rohan

    2016-01-01

    Context Rising number of diabetes cases in India calls for collaboration between the public and private sectors. Aims: Municipal Corporation of Greater Mumbai (MCGM) partnered with Eli Lilly and Company (India) [Eli Lilly] to strengthen the capacity of their diabetes clinics. Materials and Methods Medical Officers, dispensaries and Assistant Medical Officers (AMOs) located at attached health posts were trained on an educational tool, Diabetes Conversation Map™ (DCM) by a Master Trainer. This tool was then used to educate patients and caregivers visiting the MCGM diabetes clinics. Results Twenty-eight centers conducted 168 sessions, and 1616 beneficiaries availed the education over six months. General feedback from health providers was that DCM helps clear misconceptions among patients and caregivers in an interactive way and also improves compliance of patients. Conclusions This communication highlights a unique public-private partnership where the sincere efforts of public sector organization (MCGM) were complemented by the educational expertise lent by a private firm. PMID:27051094

  18. Role of momentum and velocity for radiating electrons

    NASA Astrophysics Data System (ADS)

    Capdessus, Rémi; Noble, Adam; McKenna, Paul; Jaroszynski, Dino A.

    2016-02-01

    Radiation reaction remains one of the most fascinating open questions in electrodynamics. The development of multi-petawatt laser facilities capable of reaching extreme intensities has lent this topic a new urgency, and it is now more important than ever to properly understand it. Two models of radiation reaction, due to Landau and Lifshitz and due to Sokolov, have gained prominence, but there has been little work exploring the relation between the two. We show that in the Sokolov theory, electromagnetic fields induce a Lorentz transformation between momentum and velocity, which eliminates some of the counterintuitive results of Landau-Lifshitz. In particular, the Lorentz boost in a constant electric field causes the particle to lose electrostatic potential energy more rapidly than it otherwise would, explaining the longstanding mystery of how an electron can radiate while experiencing no radiation reaction force. These ideas are illustrated in examples of relevance to astrophysics and laser-particle interactions, where radiation reaction effects are particularly prominent.

  19. Project to design and develop an energy-related program: For public housing residents and renters: Volume 1, Final report

    SciTech Connect

    Not Available

    1988-05-01

    This demonstration project was undertaken as a result of an unsolicited proposal submitted by THE ASSIGNMENT GROUP (TAG) to the Office of Minority Economic Impact, Department of Energy (DOE). The problem to which the proposal responded was how to minimize the costs associated with public housing tenants in standard public housing as well as under homeownership transfers. A related problem was how to graduate the tenants to another level of responsibility and self-sufficiency through resident business developments and training in energy-related fields. The size and gravity of the problem necessitated a purpose or aim that had nationwide application, yet lent itself to a microscopic look. Consequently, the goal that emanated was the design and development of an energy-related demonstration program that educates public housing residents, facilitates indigenous business development where appropriate, and trains residents to provide needed services.

  20. Affective reactions to pictures of ingroup and outgroup members.

    PubMed

    Brown, Lisa M; Bradley, Margaret M; Lang, Peter J

    2006-03-01

    A pervasive form of social categorization among humans is between us and them. In this study, we assessed emotional reactions when people viewed pictures depicting members of the same or different ethnic group. African American and European American participants viewed a series of pleasant and unpleasant pictures portraying either ingroup or outgroup members, while physiological, behavioral, and evaluative judgments were measured. Two hypotheses were assessed. The outgroup antipathy hypothesis predicts that people will respond to outgroup pictures with more negative affect than to ingroup pictures. In contrast, the ingroup empathy hypothesis predicts that people will show exaggerated (pleasant and unpleasant) affective responses to pictures of ingroup members, due to group identification or personal relevance. The data provided no support for the antipathy hypothesis, whereas facial EMG, skin conductance, rating, and viewing time data lent support to the ingroup empathy hypothesis, in which greater pleasure and displeasure were apparent when viewing ingroup pictures.

  1. Academic satisfaction among Latino/a and White men and women engineering students.

    PubMed

    Flores, Lisa Y; Navarro, Rachel L; Lee, Hang Shim; Addae, Dorothy A; Gonzalez, Rebecca; Luna, Laura L; Jacquez, Ricardo; Cooper, Sonya; Mitchell, Martha

    2014-01-01

    The current study tests a model of academic satisfaction in engineering based on Lent, Brown, and Hackett's (1994, 2000) social cognitive career theory among a sample of 527 engineering majors attending a Hispanic serving institution. The findings indicated that (a) an alternative bidirectional model fit the data for the full sample; (b) all of the hypothesized relations were significant for the full sample, except the path from engineering interests to goals; (c) social cognitive career theory predictors accounted for a significant amount of variance in engineering goals (26.6%) and academic satisfaction (45.1%); and (d) the model parameters did not vary across men and women or across Latino/a and White engineering undergraduate students. Implications for research and practice are discussed in relation to persistence in engineering among women and Latinos/as.

  2. AN AUTOPSIC ART: DRAWINGS OF 'DR GRANVILLE'S MUMMY' IN THE ROYAL SOCIETY ARCHIVES.

    PubMed

    Riggs, Christina

    2016-06-20

    In 1821 Augustus Bozzi Granville FRS unwrapped and dissected an ancient Egyptian mummy, presenting the results of his examination to the Royal Society in 1825. He commissioned artist Henry Perry to draw the process in stages; these drawings were subsequently engraved by James Basire for publication in Philosophical Transactions. This article presents the original drawings for the first time, allowing comparison with their engravings. Taken together with Granville's accounts of the unwrapping of the mummy, the drawings demonstrate the significant role of illustration and other visual practices in anatomical argumentation in the early nineteenth century, as well as the prestige that commissioned illustrations lent to the performance and dissemination of scientific expertise. Moreover, the drawings include one of the key visual tropes of race science--a skull in left-facing profile, mapped with a facial angle--and thus indicate the early incorporation of Egyptian mummies into typologies of race.

  3. Processing-structure characterization of rheocast IN-100 superalloy

    NASA Technical Reports Server (NTRS)

    Cheng, Jung-Jen Allen; Apelian, Diran; Doherty, Roger D.

    1986-01-01

    The rheocasting solidification process was applied in the production of IN-100 nickel base superalloy, and the effects of processing variables, such as stirring speed, isothermal stirring time, and volume fraction solid during isothermal stirring, on the resultant rheocast structure were investigated. Ingots that were furnace cooled at the same rate but without stirring were compared with the rheocast ingots. Rheocasting yielded fine-grained structures, where the extent of microsegregation, the variation in macrostructure, and the solidification-induced porosity and ingot cracking were found to be reduced in comparison to the unstirred ingots. The grain size and nonuniformity were reduced by increasing the stirring speed, isothermal stirring time, or the volume fraction solid during stirring; decreased microsegregation was achieved by an increase in the volume fraction solid. The structures of grain boundaries lent support to the grain boundary mechanism proposed by Vogel et al. (1977) for rheocasting.

  4. Sheet silicon cell/module technology

    NASA Technical Reports Server (NTRS)

    Morrison, A. D.

    1983-01-01

    The cost involved in the performance of the standard operations for the manufacture of silicon wafers is insignificant in the case of space photovoltaics applications. It is, however, a decisive factor with respect to terrestrial applications of silicon photovoltaic devices. In 1975, a program was, therefore, begun to develop low cost silicon solar arrays for terrestrial applications. The goal was silicon-based photovoltaic (PV) modules ready for installation at a selling price of $0.50/watt (1975 dollars). Sheet and ribbon silicon growth held out the promise of reduced cost through continuous operation, high material throughput, high material utilization efficiency, and a product whose shape lent itself to the assembly of high packing density modules. Attention is given to ribbon growth technologies, sheet technology generic problems, and ribbon cell and module technology status. It is concluded that the potential for crystalline ribbon silicon appears to be better today than ever before.

  5. Optimization of Orchestral Layouts Based on Instrument Directivity Patterns

    NASA Astrophysics Data System (ADS)

    Stroud, Nathan Paul

    The experience of hearing an exceptional symphony orchestra perform in an excel- lent concert hall can be profound and moving, causing a level of excitement not often reached for listeners. Romantic period style orchestral music, recognized for validating the use of intense emotion for aesthetic pleasure, was the last significant development in the history of the orchestra. In an age where orchestral popularity is waning, the possibil- ity of evolving the orchestral sound in our modern era exists through the combination of our current understanding of instrument directivity patterns and their interaction with architectural acoustics. With the aid of wave field synthesis (WFS), newly proposed variations on orchestral layouts are tested virtually using a 64-channel WFS array. Each layout is objectively and subjectively compared for determination of which layout could optimize the sound of the orchestra and revitalize the excitement of the performance.

  6. Social cognitive predictors of Mexican American college students' academic and life satisfaction.

    PubMed

    Ojeda, Lizette; Flores, Lisa Y; Navarro, Rachel L

    2011-01-01

    In this study, we used Lent's (2004) social cognitive model of well being to examine the academic and life satisfaction of 457 Mexican American college students attending a Hispanic-Serving Institution. Using structural equation modeling, results indicated that the model provided a good fit to the data. Specifically, we found positive relations from positive affect to enculturation, acculturation, college self-efficacy, academic satisfaction, and life satisfaction; from enculturation to college self-efficacy; from acculturation to college self-efficacy and college outcome expectations; from college self-efficacy to college outcome expectations, academic goal progress, academic satisfaction, and life satisfaction; from college outcome expectations to academic satisfaction; from academic goal progress to academic and life satisfaction; and from academic satisfaction to life satisfaction. Findings indicated the model was invariant across gender groups, and overall, 38% and 14% of the variance in academic satisfaction and life satisfaction, respectively, were explained by the predictor variables. Implications for research and practice are discussed.

  7. [José Lima Pedreira de Freitas and the redefinition and control of Chagas disease].

    PubMed

    Rocha, Juan Stuardo Yazlle

    2016-08-01

    A brief overview of the evolution of knowledge about Chagas disease since its discovery by Carlos Chagas in 1909 until the mid-1940s is presented. The trajectory of physician Pedreira de Freitas and his growing involvement in research in the area led to his contributions to laboratory diagnosis - which lent consistency and security to epidemiological surveys of Chagas disease - and the redefinition of the scale of the disease in Brazil and the Americas with its terrible social and economic impact. His proposal for the disease prevention model - based on selective purging in the application of insecticide - was adopted nationally and internationally and made it possible to bring the disease under control in Brazil and other countries. He devoted himself with equal intensity to enhancing the teaching of medical practices in the community and was a pioneer in the implementation of preventive medicine in medical education in Brazil. PMID:27557035

  8. Building the new schoolhouse: the Massachusetts school building authority.

    PubMed

    Ames, Jennifer; Levenstein, Charles

    2013-01-01

    In a 2010 special issue of New Solutions on school health and environment, Paulson and Barnett asked who is responsible for the environmental health of schools. The Massachusetts School Building Authority (MSBA), the product of liberals trying to bring organization and efficiency to school construction, is an "off-label" and only partial answer to the question. The MSBA, established in 2004, lent its ear to health and safety advocates who seized an opportunity to implement regulations, guidelines, and education reforms at the level of school construction. The MSBA's progressiveness is a model to localities and states across the United States facing the dual crisis of attacks on public education and financial inefficiency. However, the MSBA is still in its infancy. Time will tell whether the MSBA, viewed as a limited state pilot program, can survive and expand its environmental health programs or whether its initiative is only as good as its current leadership.

  9. From a pump handle to oral rehydration therapy: a model of translational research.

    PubMed

    Schultz, Stanley G

    2007-12-01

    Few afflictions have attracted as much attention and impacted on as many societal and biomedical areas as cholera. Dr. John Snow's studies launched the field of epidemiology, were early applications of medical cartography, and promoted the use of statistical methods in medicine. The finding that cholera was due to the ingestion of contaminated water lent to the demise of the prevalent "miasmatic theory of contagion," set the platform for the "germ theory of disease," and promoted the growth of public health concerns for water purification and sanitation. More recent attention to this disease led to the notion of "secretory diarrhea" and the translation of basic principles to the development of oral rehydration therapy and its "spin-offs" (Gatorade and Pedilyte).

  10. AN AUTOPSIC ART: DRAWINGS OF 'DR GRANVILLE'S MUMMY' IN THE ROYAL SOCIETY ARCHIVES.

    PubMed

    Riggs, Christina

    2016-06-20

    In 1821 Augustus Bozzi Granville FRS unwrapped and dissected an ancient Egyptian mummy, presenting the results of his examination to the Royal Society in 1825. He commissioned artist Henry Perry to draw the process in stages; these drawings were subsequently engraved by James Basire for publication in Philosophical Transactions. This article presents the original drawings for the first time, allowing comparison with their engravings. Taken together with Granville's accounts of the unwrapping of the mummy, the drawings demonstrate the significant role of illustration and other visual practices in anatomical argumentation in the early nineteenth century, as well as the prestige that commissioned illustrations lent to the performance and dissemination of scientific expertise. Moreover, the drawings include one of the key visual tropes of race science--a skull in left-facing profile, mapped with a facial angle--and thus indicate the early incorporation of Egyptian mummies into typologies of race. PMID:27386713

  11. Longwall Guidance and Control Development

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The longwall guidance and control (G&C) system was evaluated to determine which systems and subsystems lent themselves to automatic control in the mining of coal. The upper coal/shale interface was identified as the reference for a vertical G&C system, with two sensors (the natural backgound and the sensitized pick) being used to locate and track this boundary. In order to insure a relatively smooth recession surface (roof and floor of the excavated seam), a last and present cut measuring instrument (acoustic sensor) was used. Potentiometers were used to measure elevations of the shearer arms. The intergration of these components comprised the vertical control system (pitch control). Yaw and roll control were incorporated into a face alignment system which was designed to keep the coal face normal to its external boundaries. Numerous tests, in the laboratory and in the field, have confirmed the feasibility of automatic horizon control, as well as determining the face alignment.

  12. R. A. Fisher: a faith fit for eugenics.

    PubMed

    Moore, James

    2007-03-01

    In discussions of 'religion-and-science', faith is usually emphasized more than works, scientists' beliefs more than their deeds. By reversing the priority, a lingering puzzle in the life of Ronald Aylmer Fisher (1890-1962), statistician, eugenicist and founder of the neo-Darwinian synthesis, can be solved. Scholars have struggled to find coherence in Fisher's simultaneous commitment to Darwinism, Anglican Christianity and eugenics. The problem is addressed by asking what practical mode of faith or faithful mode of practice lent unity to his life? Families, it is argued, with their myriad practical, emotional and intellectual challenges, rendered a mathematically-based eugenic Darwinian Christianity not just possible for Fisher, but vital.

  13. Applications of finite element and wave envelope element approximations to turbofan engine noise radiation including flight effects

    NASA Technical Reports Server (NTRS)

    Parrett, A. V.; Eversman, W.

    1984-01-01

    The problem of acoustic radiation from turbofan engine inlets in flow has not lent itself fully to analysis by numerical means because of the large domains and high frequencies involved. The current work has extended the use of finite elements and wave envelope elements, elements which simulate decay and wavelike behaviour in their interpolation functions, from the no-flow case in which they have been proven, to cases incorporating mean flow. By employing an irrotational mean flow assumption, the acoustics problem has been posed in an axisymmetric formulation in terms of acoustic velocity potential, thus minimizing computer solution storage requirements. The results obtained from the numerical procedures agree well with known analytical solutions, static experimental jet engines inflow data, and also with flight test results.

  14. Applications of finite and wave envelope element approximations to acoustic radiation from turbofan engine inlets in flight

    NASA Astrophysics Data System (ADS)

    Parrett, A. V.

    1984-12-01

    The problem of acoustic radiation from turbofan engine inlets in flow has not lent itself fully to analysis by numerical means because of the large domains and high frequencies involved. The use of finite elements and wave envelope elements, elements which simulate decay and wavelike behavior in their interpolation functions were extended from the no-flow case in which they were proven, to cases incorporating mean flow. By employing an irrotational mean flow assumption, the acoustics problem was posed in axisymmetric formulation in terms of acoustic velocity potential, thus minimizing computer solution storage requirements. The results obtained from the numerical procedures agree well with known analytical solutions and static jet engine inflow experimental data. Some discrepancy with flight test data exists but the combined finite element-wave envelope element solution radiation directivity trends are in good agreement with analytical predictions.

  15. Applications of finite element and wave envelope element approximations to turbofan engine noise radiation including flight effects

    NASA Astrophysics Data System (ADS)

    Parrett, A. V.; Eversman, W.

    1984-10-01

    The problem of acoustic radiation from turbofan engine inlets in flow has not lent itself fully to analysis by numerical means because of the large domains and high frequencies involved. The current work has extended the use of finite elements and wave envelope elements, elements which simulate decay and wavelike behaviour in their interpolation functions, from the no-flow case in which they have been proven, to cases incorporating mean flow. By employing an irrotational mean flow assumption, the acoustics problem has been posed in an axisymmetric formulation in terms of acoustic velocity potential, thus minimizing computer solution storage requirements. The results obtained from the numerical procedures agree well with known analytical solutions, static experimental jet engines inflow data, and also with flight test results.

  16. Laser-induced fluorescence of space-exposed polyurethane

    NASA Technical Reports Server (NTRS)

    Hill, Ralph H., Jr.

    1993-01-01

    The object of this work was to utilize laser-induced fluorescence technique to characterize several samples of space-exposed polyurethane. These samples were flown on the Long Duration Exposure Facility (LDEF), which was in a shuttle-like orbit for nearly 6 years. Because of our present work to develop laser-induced-fluorescence inspection techniques for polymers, space-exposed samples and controls were lent to us for evaluation. These samples had been attached to the outer surface of LDEF; therefore, they were subjected to thermal cycling, solar ultraviolet radiation, vacuum, and atomic oxygen. It is well documented that atomic oxygen and ultraviolet exposure have detrimental effects on many polymers. This was a unique opportunity to make measurements on material that had been naturally degraded by an unusual environment. During our past work, data have come from artificially degraded samples and generally have demonstrated a correlation between laser-induced fluorescence and tensile strength or elasticity.

  17. Chinese College Test Takers' Individual Differences and Reading Test Performance: A Structural Equation Modeling Approach.

    PubMed

    Zhang, Limei

    2016-06-01

    This study reports on the relationships between test takers' individual differences and their performance on a reading comprehension test. A total of 518 Chinese college students (252 women and 256 men; M age = 19.26 year, SD = 0.98) answered a questionnaire and sit for a reading comprehension test. The study found that test takers' L2 language proficiency was closely linked to their test performance. Test takers' employment of strategies was significantly and positively associated with their performance on the test. Test takers' motivation was found to be significantly associated with reading test performance. Test anxiety was negatively related to their use of reading strategies and test performance. The results of the study lent support to the threshold hypothesis of language proficiency. The implications for classroom teaching were provided.

  18. [Trust as a fundamental key for management in the service of people: Robert Spaemann's work].

    PubMed

    Marco Perles, Ginés Santiago

    2008-01-01

    In the present paper, we analyse the role of trust in the search for truthful health management in the service of people, bearing in mind the considerations of Robert Spaemann, Emeritus Professor of Ethics and Politics at the University of Munich. According to this author, trust is an intangible asset which helps the transmission of knowledge and the voluntary assumption of responsibility. In the first place, the transfer of knowledge, because the credibility of any professional involved in health management is threatened when such activity is carried out in a scenario in which managers may provide incentives for just the opposite of cooperative knowledge, so that transparency in the transmission of truth and "getting on" in one's career may appear in conflict. Secondly, the voluntary assumption of responsibilities, because the credibility of a health manager is lent weight when, in any contingency, he/she regularly puts the interests of patients before personal interests.

  19. Carcinome papillaire intra-kystique du sein: à propos de trois cas

    PubMed Central

    El Mazghi, Abderrahman; Bouhafa, Touria; Loukili, Kaoutar; El Kacemi, Hanan; Lalya, Issam; Kebdani, Taieb; Hassouni, Khalid

    2014-01-01

    Le Carcinome papillaire intra-kystique du sein est une entité très rare et représente 0,5 à 1% de l'ensemble des carcinomes mammaires. Il se caractérise généralement par une croissance lente avec un bon pronostic. Nous rapportons 03 nouveaux cas prouvés histologiquement, chez des patientes traitées par chirurgie radicale ou conservatrice, suivie d'une radiothérapie sur le sein en place et une hormonothérapie à base de tamoxifen chez les deux patientes avec des récepteurs hormonaux positifs. Les trois patientes sont en bon contrôle locorégionale avec des suivis post-thérapeutiques de 12 à 18 mois. PMID:25419333

  20. Examining the career development of Mexican American middle school students: A test of social cognitive career theory

    NASA Astrophysics Data System (ADS)

    Navarro, Rachel Leah

    This study tested portions of Lent, Brown, and Hackett's (1994) Social Cognitive Career Theory (SCCT) in the domain of mathematics and science with a sample of Mexican American middle school students. Results supported a modified path model. This study's findings supported several SCCT propositions regarding the positive relationships among background contextual affordances, learning experiences, self-efficacy, outcome expectations, interests, and goals. However, findings suggested that the influence of person inputs (i.e., gender and generational status) and some background contextual affordances (i.e., acculturation level) on learning experiences may be not be direct; instead, an indirect effect via a relationship with other background contextual affordances (i.e., perceived social support and social class) was found. Furthermore, results supported direct effects of gender on self-efficacy and learning experiences on goal intentions---two relationships not posited in SCCT. Implications for future research and counseling with Mexican American adolescents are discussed.

  1. Media Use, Cognitive Performance, and Life Satisfaction of the Chinese Elderly.

    PubMed

    Sun, Shaojing; Zhang, Shuangyue; Fan, Xitao

    2016-10-01

    Media use and aging is an important interdisciplinary topic pertaining to communication, gerontology, and psychology, among others. Integrating research on media-induced recovery and life satisfaction, the present study examined media uses and effects in the context of health and aging. Specifically, data from a large random sample were analyzed to investigate the relationships between media use, cognitive performance, and life satisfaction among the Chinese elderly. Results, in general, lent support to the slightly modified structural model. Specifically, media-induced recovery outcomes can be categorized into proximate (e.g., cognitive performance), intermediate (e.g., health satisfaction), and distal levels (e.g., life satisfaction). Also, situational factors (e.g., disease history) had statistically significant effects on media-induced recovery outcomes. Theoretical and practical implications of the research findings were discussed, and future research directions were suggested. PMID:26933791

  2. [Prominence in the media, renown in the sciences: the construction of a paradigmatic feminist and a scientist at Rio de Janeiro's Museu Nacional].

    PubMed

    Lopes, Maria Margaret

    2008-06-01

    Bertha Lutz was one of the women of her generation who enjoyed indisputable political and scientific authority. She wrote much and even more was written about her, especially during her day. The newspaper chronicles by Lima Barreto, countless letters, scientific papers, and unpublished texts by Bertha herself that are surveyed in this article indicate how much her feminism--inseparable from other dimensions of her life--fostered her professional career. Her feminism earned her a carefully constructed renown and visibility that interlocked with her professional performance. Science lent her social prestige and guaranteed legitimacy for her causes. During a period when the scientific community itself was engaged in publicizing its own activities, Bertha's feminist prominence in the media helped her make a name in the sciences. PMID:19397030

  3. Ancient trans-Acting siRNAs Confer Robustness and Sensitivity onto the Auxin Response.

    PubMed

    Plavskin, Yevgeniy; Nagashima, Akitomo; Perroud, Pierre-François; Hasebe, Mitsuyasu; Quatrano, Ralph S; Atwal, Gurinder S; Timmermans, Marja C P

    2016-02-01

    Novel developmental programs often evolve via cooption of existing genetic networks. To understand this process, we explored cooption of the TAS3 tasiRNA pathway in the moss Physcomitrella patens. We find an ancestral function for this repeatedly redeployed pathway in the spatial regulation of a conserved set of Auxin Response Factors. In moss, this results in stochastic patterning of the filamentous protonemal tissue. Through modeling and experimentation, we demonstrate that tasiRNA regulation confers sensitivity and robustness onto the auxin response. Increased auxin sensitivity parallels increased developmental sensitivity to nitrogen, a key environmental signal. We propose that the properties lent to the auxin response network, along with the ability to stochastically modulate development in response to environmental cues, have contributed to repeated cooption of the tasiRNA-ARF module during evolution. The signaling properties of a genetic network, and not just its developmental output, are thus critical to understanding evolution of multicellular forms.

  4. Healing and the invention of metaphor: the effectiveness of symbols revisited.

    PubMed

    Kirmayer, L J

    1993-06-01

    In this essay, I argue that a theory of meaning adequate to account for the effectiveness of symbolic healing and psychotherapy requires some variant of the three concepts of myth, metaphor and archetype. Myth stands for the overarching narrative structures of the self produced and lent authority by cultural tradition. Archetype stands not for performed ideas or images, but for the bodily-given in meaning. Metaphor occupies an intermediate realm, linking narrative and bodily-given experience through imaginative constructions and enactments that allow movement in sensory-affective quality space. This pluralistic perspective itself constitutes a middle-ground between constructivist and realist approaches to meaning that can integrate causal and interpretive models of symbolic healing.

  5. Building the new schoolhouse: the Massachusetts school building authority.

    PubMed

    Ames, Jennifer; Levenstein, Charles

    2013-01-01

    In a 2010 special issue of New Solutions on school health and environment, Paulson and Barnett asked who is responsible for the environmental health of schools. The Massachusetts School Building Authority (MSBA), the product of liberals trying to bring organization and efficiency to school construction, is an "off-label" and only partial answer to the question. The MSBA, established in 2004, lent its ear to health and safety advocates who seized an opportunity to implement regulations, guidelines, and education reforms at the level of school construction. The MSBA's progressiveness is a model to localities and states across the United States facing the dual crisis of attacks on public education and financial inefficiency. However, the MSBA is still in its infancy. Time will tell whether the MSBA, viewed as a limited state pilot program, can survive and expand its environmental health programs or whether its initiative is only as good as its current leadership. PMID:23896077

  6. Productivity --- 8 for 8. [Labor Relations at Gulf Oil

    SciTech Connect

    Breaux, M.P.

    1983-03-01

    According to the author, a spokesman for Gulf Oil Corporation, the petroleum industry in the United States has reason to be proud of its record in labor relations, in labor negotiations, and in the success of its bargaining. For many years, this industry found itself alone in advocating noncompliance with COLAs and not participating in fully paid medical plans and other labor programs other industries felt it necessary to adopt and underwrite. This staunch resistance lent the petroleum industry, over the years, the reputation of an industrial dinosaur, but this has lately changed as industry at large, especially during an economic recession, has seen the wisdom behind the motives of the petroleum industry. The author goes on to state that Gulf's employees are well paid and that the last contract, stipulating a 9 percent and 7 percent increase over the next two years, was a bilaterally fair settlement.

  7. From closed ranks to open doors: Elaine and John Cummings' mental health education experiment in 1950s Saskatchewan.

    PubMed

    Kendall, Kathleen

    2011-01-01

    During late 1951 and early 1952, married couple, social biologist Elaine Cumming and psychiatrist John Cumming, led a mental health education experiment in Indian Head, Saskatchewan. The study, which was intended to inform strategies toward deinstitutionalization, sought to determine if attitudes regarding mental illness could be changed through commonly used educational practices. It was shaped by the shared interests of powerful philanthropic, charitable, psychiatric, academic and governmental bodies to create healthier citizens and a stronger democratic nation through expert knowledge. However, in addition to the disappointing findings indicating that attitudes remained unchanged, the town appeared to close ranks against the research team. Nonetheless, the Cummings' later association with sociologists at Harvard University enabled them to interpret the results in a way that lent the study credibility and themselves legitimacy, thus opening the door to their careers as very successful researchers and policy-makers. PMID:22514867

  8. The role of personal practice theories in the professional development of a beginning high school chemistry teacher

    NASA Astrophysics Data System (ADS)

    Sweeney, Aldrin E.; Bula, Oleh A.; Cornett, Jeffrey W.

    2001-04-01

    The notion of deliberated teacher reflection as a means of improving professional teaching practice has become one of the most pervasive concepts to influence science teacher education during the past decade. In this case study, we use the notion of teacher reflection and Lytle and Cochran-Smith's ([1990]) typology of teacher research to examine the relationships between a beginning high school chemistry teacher's articulated personal practice theories and his actions as demonstrated by his curricular decisions and instructional practices. In so doing, we describe the ways in which the formal articulations of this teacher's personal practice theories lent themselves to his development as a teacher/researcher and propose this development as a useful model of science teacher practitioner professionalism.

  9. High-energy nearshore processes

    USGS Publications Warehouse

    1986-01-01

    The problem of shoreline erosion has become a matter of much interest in the recent press. To some extent this interest has been driven by the slow rise in sea level that has lent an air of inevitabilty to matters. However, the discussions certainly become more focused by the approach of a major storm or hurricane: for instance, the 1985 scare associated with Hurricane Gloria. In fact, it is these major events that dominate the episodic erosion history of an area, and so it is on the basis of knowledge of these events that decisions are made on the development and management of our shorelines. Unfortunately, both our understanding of the fundamental processes and the extent to which our knowledge is transmitted to coastal planners is less than we might hope.

  10. High-energy nearshore processes

    NASA Astrophysics Data System (ADS)

    Holman, R. A.; Sallenger, A. H., Jr.

    The problem of shoreline erosion has become a matter of much interest in the recent press. To some extent this interest has been driven by the slow rise in sea level that has lent an air of inevitabilty to matters. However, the discussions certainly become more focused by the approach of a major storm or hurricane: for instance, the 1985 scare associated with Hurricane Gloria. In fact, it is these major events that dominate the episodic erosion history of an area, and so it is on the basis of knowledge of these events that decisions are made on the development and management of our shorelines. Unfortunately, both our understanding of the fundamental processes and the extent to which our knowledge is transmitted to coastal planners is less than we might hope.

  11. Through-the-earth communication: Experiment results from Billie Mine and Mississippi Chemical Mine

    NASA Astrophysics Data System (ADS)

    Buettner, H. M.; Didwall, E. M.; Bukofzer, D. C.

    1988-06-01

    As part of the Lawrence Livermore National Laboratory (LLNL) effort to evaluate Through-the-Earth Communication (TEC) as an option for military communication systems, experiments were conducted involving transmission, reception, and performance monitoring of digital electromagnetic communication signals propagating through the earth. The two experiments reported on here not only demonstrated that TEC is useful for transmissions at digital rates above a few bits per second, but also provided data on performance parameters with which to evaluate TEC in various military applications. The most important aspect of these experiments is that the bit error rate (BER) is measured rather than just estimated from purely analytic developments. By measuring this important parameter, not only has more credibility been lent to the proof of concept goals of the experiment, but also a means for judging the effects of assumptions in BER theoretical models has been provided.

  12. A SYNCHRONIZED FIR/VUV LIGHT SOURCE AT JEFFERSON LAB

    SciTech Connect

    Stephen Benson, David Douglas, George Neil, Michelle D. Shinn, Gwyn Williams

    2012-07-01

    We describe a dual free-electron laser (FEL) configuration on the UV Demo FEL at Jefferson Lab that allows simultaneous lasing at FIR/THz and UV wavelengths. The FIR/THz source would be an FEL oscillator with a short wiggler providing nearly diffraction-limited pulses with pulse energy exceeding 50 microJoules. The FIR source would use the exhaust beam from a UVFEL. The coherent harmonics in the VUV from the UVFEL are out-coupled through a hole. The FIR source uses a shorter resonator with either hole or edge coupling to provide very high power FIR pulses. Simulations indicate excel-lent spectral brightness in the FIR region with over 100 W/cm-1 output.

  13. Effects of natural and anneal-induced oxides on atomic-layer-deposition Al2O3/In0.53Ga0.47As interfaces

    NASA Astrophysics Data System (ADS)

    Yoshida, Toshiyuki

    2015-01-01

    To investigate the effects of the surface residual oxide on the interface properties of atomic-layer-deposition (ALD) Al2O3/In0.53Ga0.47As structures, we prepared various types of pre-ALD surfaces with different ratios and amounts of oxide components. All of the surfaces showed high mid-gap state densities, and the existence of the As5+ component lent a small advantage to the capacitance-voltage (C-V) behavior. By interrupting the ALD process and applying the annealing process in N2 or O2 atmosphere, additional oxide components were introduced extrinsically, which increased the mid-gap state density. The post-metallization annealing process was effective for removing the mid-gap states originating from both the native and extrinsic oxide components.

  14. Media Use, Cognitive Performance, and Life Satisfaction of the Chinese Elderly.

    PubMed

    Sun, Shaojing; Zhang, Shuangyue; Fan, Xitao

    2016-10-01

    Media use and aging is an important interdisciplinary topic pertaining to communication, gerontology, and psychology, among others. Integrating research on media-induced recovery and life satisfaction, the present study examined media uses and effects in the context of health and aging. Specifically, data from a large random sample were analyzed to investigate the relationships between media use, cognitive performance, and life satisfaction among the Chinese elderly. Results, in general, lent support to the slightly modified structural model. Specifically, media-induced recovery outcomes can be categorized into proximate (e.g., cognitive performance), intermediate (e.g., health satisfaction), and distal levels (e.g., life satisfaction). Also, situational factors (e.g., disease history) had statistically significant effects on media-induced recovery outcomes. Theoretical and practical implications of the research findings were discussed, and future research directions were suggested.

  15. Toward Proof of Concept of a One Health Approach to Disease Prediction and Control

    PubMed Central

    Kock, Richard; Kachani, Malika; Kunkel, Rebekah; Thomas, Jason; Gilbert, Jeffrey; Wallace, Robert; Blackmore, Carina; Wong, David; Karesh, William; Natterson, Barbara; Dugas, Raymond; Rubin, Carol

    2013-01-01

    A One Health approach considers the role of changing environments with regard to infectious and chronic disease risks affecting humans and nonhuman animals. Recent disease emergence events have lent support to a One Health approach. In 2010, the Stone Mountain Working Group on One Health Proof of Concept assembled and evaluated the evidence regarding proof of concept of the One Health approach to disease prediction and control. Aspects examined included the feasibility of integrating human, animal, and environmental health and whether such integration could improve disease prediction and control efforts. They found evidence to support each of these concepts but also identified the need for greater incorporation of environmental and ecosystem factors into disease assessments and interventions. The findings of the Working Group argue for larger controlled studies to evaluate the comparative effectiveness of the One Health approach. PMID:24295136

  16. [My 25th anniversary with the academy. An excuse to remember some old friends who have disapeared].

    PubMed

    Cruz Hermida, Julio

    2005-01-01

    As the author reaches his 25th anniversary with R.A.N.M., he remembers the academics therein, whom he found in the year of his entry (November, 1980), in the midst of life and work, and with whom he closely spent the following years, yielding anecdotal and human brush strokes through our brief pesonal encounters. Before remembering the academics now gone, we note another of those relationships, begun like the others in the some year and, happily, still maintaining today the precious gift of life. This exercise in historical reporting in which the memory does justice to those names that lent their prestige to Spanish Medicine, is not meant -in the words of Profesor Cruz y Hermida- to be a chapter in the history of medicine, but rather a page in the history of the National Royal Academy of Medicine.

  17. Sexual networks and housing stability.

    PubMed

    Davey-Rothwell, Melissa A; Latimore, Amanda; Hulbert, Alicia; Latkin, Carl A

    2011-08-01

    Unstable housing is related to a range of health problems including substance abuse, poor mental health, and HIV. Little is known about how sexual partners' attributes influence access to resources such as housing. The purpose of the present study was to examine the relationship between sexual network characteristics and improvements in housing situation among a sample of drug users using a longitudinal design. Size of one's sex network was not associated with housing change. However, having a main partner and having a sex partner who lent money was associated with moving from a homeless state at baseline to being housed at follow-up. Also, having a sex partner who was a drug user was associated with decrease in the odds of improving one's housing situation.

  18. Status of SOFCo SOFC technology development

    SciTech Connect

    Privette, R.; Perna, M.A.; Kneidel, K.

    1996-12-31

    SOFCo, a Babcock & Wilcox/Ceramatec Research & Development Limited Partnership, is a collaborative research and development venture to develop technologies related to planar, solid-oxide fuel cells (SOFCs). SOFCo has successfully demonstrated a kW-class, solid-oxide fuel cell module operating on pipeline natural gas. The SOFC system design integrates the air preheater and the fuel processor with the fuel cell stacks into a compact test unit; this is the platform for multi-kW modules. The cells, made of tape-cast zirconia electrolyte and conventional electrode materials, exhibit excel lent stability in single-cell tests approaching 40,000 hours of operation. Stack tests using 10-cm and 15-cm cells with ceramic interconnects also show good performance and stability in tests for many thousands of hours.

  19. The search for protection against HIV infection.

    PubMed

    Detels, Roger

    2009-04-01

    More than 25 years after the recognition of AIDS and the isolation of the causative agent, human immunodeficiency virus (HIV), we have been unable to develop a vaccine to protect against infection. The major obstacle to development of a vaccine has been the absence of naturally acquired protective immunity, which is characteristic of most infectious agents. We and others, however, have identified individuals who appear to be resistant to infection. Using a combination of epidemiology, molecular biology, and genetics, we hypothesize that these individuals are able to resist infection by clearing low doses of HIV from their systems. We further hypothesize that they are able to clear the virus through a highly efficient system of processing and presentation of HIV epitopes (antigens) to CD8+ cytotoxic cells, which activate them to remove virally infected cells. Subsequent studies have lent support to this hypothesis. PMID:19344863

  20. From closed ranks to open doors: Elaine and John Cummings' mental health education experiment in 1950s Saskatchewan.

    PubMed

    Kendall, Kathleen

    2011-01-01

    During late 1951 and early 1952, married couple, social biologist Elaine Cumming and psychiatrist John Cumming, led a mental health education experiment in Indian Head, Saskatchewan. The study, which was intended to inform strategies toward deinstitutionalization, sought to determine if attitudes regarding mental illness could be changed through commonly used educational practices. It was shaped by the shared interests of powerful philanthropic, charitable, psychiatric, academic and governmental bodies to create healthier citizens and a stronger democratic nation through expert knowledge. However, in addition to the disappointing findings indicating that attitudes remained unchanged, the town appeared to close ranks against the research team. Nonetheless, the Cummings' later association with sociologists at Harvard University enabled them to interpret the results in a way that lent the study credibility and themselves legitimacy, thus opening the door to their careers as very successful researchers and policy-makers.

  1. A longitudinal examination of adolescent career planning and exploration using a social cognitive career theory framework.

    PubMed

    Rogers, Mary E; Creed, Peter A

    2011-02-01

    This study used social cognitive career theory (Lent, Brown, & Hackett, 1994), as a framework to investigate predictors of career choice actions, operationalised as career planning and career exploration. The model was tested cross-sectionally and longitudinally with 631 high school students enrolled in Grades 10-12. Students completed measures of self-efficacy, outcome expectations, goals, supports and personality. Results of the hierarchical regression analyses indicated strong support for self-efficacy and goals predicting career planning and exploration across all grades at T1, and predicting change in career planning and exploration from T1 to T2. Whilst support for pathways among other predictor variables (personality, contextual influences and biographic variables) to choice actions was found, these pathways varied across grades at T1, and also from T1 to T2. Implications for social cognitive career theory, career counselling practice and future research are discussed.

  2. Mitoepigenetics: The different shades of grey.

    PubMed

    Ghosh, Sourav; Singh, Keshav K; Sengupta, Shantanu; Scaria, Vinod

    2015-11-01

    Epigenetic modifications of the nuclear genome have been well studied and it is established that these modifications play a key role in nuclear gene expression. However, the status of mitochondrial epigenetic modifications has not been delved in detail. The recent technological advancements in the genome analyzing tools and techniques, have helped in investigating mitochondrial epigenetic modifications with greater resolution and studies have indicated a regulatory role of the mitochondrial epigenome. Association of mitochondrial DNA methylation with various disease conditions, drug treatment, aging, exposure to environmental pollutants etc. has lent credence to this belief. Herein, we have reviewed studies on mitochondrial epigenetic modifications with a focus to comprehend its regulatory role in gene expression and disease association.

  3. World Bank's support for science and technology

    SciTech Connect

    Weiss, C. Jr.

    1985-01-18

    The World Bank, the largest aid-granting agency in the world, has played a substantial but largely unsung role in helping the scientific and technological development of developing countries. Its investments, totaling $15.5 billion in fiscal year 1984, involve choosing appropriate technology and financing local technological development. Since 1980, the Bank has lent $0.5 billion for agricultural research and about $1 billion for scientific and technological education. It contributes to and mobilizes finances for large international research programs in agriculture and the health sciences. It supports research on labor-based construction, low-cost sanitation, renewable energy resources, and control of traffic congestion. It provides training in the technological aspects of development policy. As funds for aid become scarce, the Bank is reexamining its approach to science and technology.

  4. Chinese College Test Takers' Individual Differences and Reading Test Performance: A Structural Equation Modeling Approach.

    PubMed

    Zhang, Limei

    2016-06-01

    This study reports on the relationships between test takers' individual differences and their performance on a reading comprehension test. A total of 518 Chinese college students (252 women and 256 men; M age = 19.26 year, SD = 0.98) answered a questionnaire and sit for a reading comprehension test. The study found that test takers' L2 language proficiency was closely linked to their test performance. Test takers' employment of strategies was significantly and positively associated with their performance on the test. Test takers' motivation was found to be significantly associated with reading test performance. Test anxiety was negatively related to their use of reading strategies and test performance. The results of the study lent support to the threshold hypothesis of language proficiency. The implications for classroom teaching were provided. PMID:27173665

  5. Brain Injury After Proton Therapy or Carbon Ion Therapy for Head-and-Neck Cancer and Skull Base Tumors

    SciTech Connect

    Miyawaki, Daisuke Murakami, Masao; Demizu, Yusuke; Sasaki, Ryohei; Niwa, Yasue; Terashima, Kazuki; Nishimura, Hideki; Hishikawa, Yoshio; Sugimura, Kazuro

    2009-10-01

    Purpose: To assess the incidence of early delayed or late morbidity of Brain after particle therapy for skull base tumors and head-and-neck cancers. Methods and Materials: Between May 2001 and December 2005, 59 patients with cancerous invasion of the skull base were treated with proton or carbon ion therapy at the Hyogo Ion Beam Medical Center. Adverse events were assessed according to the magnetic resonance imaging findings (late effects of normal tissue-subjective, objective, management, analytic [LENT-SOMA]) and symptoms (Common Terminology Criteria for Adverse Events [CTCAE], version 3.0). Dose-volume histograms were used to analyze the relationship between the dose and volume of the irradiated brain and the occurrence of brain injury. The median follow-up time was 33 months. Results: Of the 48 patients treated with proton therapy and 11 patients treated with carbon ion radiotherapy, 8 (17%) and 7 (64%), respectively, developed radiation-induced brain changes (RIBCs) on magnetic resonance imaging (LENT-SOMA Grade 1-3). Four patients (7%) had some clinical symptoms, such as vertigo and headache (CTCAE Grade 2) or epilepsy (CTCAE Grade 3). The actuarial occurrence rate of RIBCs at 2 and 3 years was 20% and 39%, respectively, with a significant difference in the incidence between the proton and carbon ion radiotherapy groups. The dose-volume histogram analyses revealed significant differences between Brain lobes with and without RIBCs in the actuarial volume of brain lobes receiving high doses. Conclusion: Particle therapies produced minimal symptomatic brain toxicities, but sequential evaluation with magnetic resonance imaging detected a greater incidence of RIBCs. Significant differences were observed in the irradiated brain volume between Brain lobes with and without RIBCs.

  6. Imagerie Resolue dans le Temps des Photons et Neutres Metastables Emis D'une Surface Par Stimulation Electronique

    NASA Astrophysics Data System (ADS)

    Leclerc, Gregoire

    L'appareil que nous presentons ici a ete mis au point pour permettre d'accumuler des images numeriques, resolues dans le temps, de la desorption par stimulation electronique (DSE) d'ions positifs et negatifs, de photons et de neutres metastables, tout en conservant des capacites de base de diffraction d'electrons lents (DEL) et de transmission d'electrons lents (TEL). Le spectrometre comporte un monochromateur d'electrons a secteur cylindrique de 127^ circ dont l'optique de sortie permet la focalisation du faisceau d'electrons sur une large gamme d'energies. Le detecteur consiste en un empilement de galettes de microcanaux et d'une anode resistive a encodage de division de charges. La reponse spatiale du detecteur a ete calibree et plusieurs causes de non-linearite ont ete localisees et corrigees. Des methodes de correction materielle et logicielle des distorsions spatiales sont presentees. La resolution temporelle des evenements est obtenue en pulsant le faisceau d'electrons, et de facon synchrone la detection, laquelle est couplee a un micro-ordinateur. La premiere partie de ce travail est consacree a la caracterisation du spectrometre et la presentation de nombreux parametres operationnels, obtenus soit au moment de la conception, soit experimentalement. Suit la presentation de donnees de DEL et de DSE pour le systeme Ar/Pt(111) en films minces a 15K. Les sequences temporelles d'images de metastables d'Ar desorbes ont revele la presence de plusieurs populations distinctes, ayant des distributions angulaires et distributions d'energie cinetique que nous avons pu separer. Les fonctions d'excitation de l'emission de photons et de la desorption de differentes composantes de metastables, ainsi que la dependance de ces signaux sur l'epaisseur des films d'Ar, sont aussi presentees et analysees. Les techniques que nous avons developpees ont permis de cerner les mecanismes en jeu pour la desorption et la luminescence.

  7. Quality of Life Assessment After Concurrent Chemoradiation for Invasive Bladder Cancer: Results of a Multicenter Prospective Study (GETUG 97-015)

    SciTech Connect

    Lagrange, Jean-Leon; Bascoul-Mollevi, Caroline; Geoffrois, Lionnel; Beckendorf, Veronique; Ferrero, Jean-Marc; Joly, Florence; Allouache, Nedjila; Bachaud, Jean-Marc; Chevreau, Christine; Kramar, Andrew; Chauvet, Bruno

    2011-01-01

    Purpose: To evaluate bladder preservation and functional quality after concurrent chemoradiotherapy for muscle-invasive cancer in 53 patients included in a Phase II trial. Patient and Methods: Pelvic irradiation delivered 45Gy, followed by an 18-Gy boost. Concurrent chemotherapy with cisplatin and 5-fluorouracil by continuous infusion was performed at Weeks 1, 4, and 7 during radiotherapy. Patients initially suitable for surgery were evaluated with macroscopically complete transurethral resection after 45Gy, followed by radical cystectomy in case of incomplete response. The European Organization for Research and Treatment of Cancer quality of life questionnaire QLQ-C30, specific items on bladder function, and the Late Effects in Normal Tissues-Subjective, Objective, Management, and Analytic (LENT-SOMA) symptoms scale were used to evaluate quality of life before treatment and 6, 12, 24, and 36 months after treatment. Results: Median age was 68 years for 51 evaluable patients. Thirty-two percent of patients had T2a tumors, 46% T2b, 16% T3, and 6% T4. A visibly complete transurethral resection was possible in 66%. Median follow-up was 8 years. Bladder was preserved in 67% (95% confidence interval, 52-79%) of patients. Overall survival was 36% (95% confidence interval, 23-49%) at 8 years for all patients, and 45% (28-61%) for the 36 patients suitable for surgery. Satisfactory bladder function, according to LENT-SOMA, was reported for 100% of patients with preserved bladder and locally controlled disease 6-36 months after the beginning of treatment. Satisfactory bladder function was reported for 35% of patients before treatment and for 43%, 57%, and 29%, respectively, at 6, 18, and 36 months. Conclusions: Concurrent chemoradiation therapy allowed bladder preservation with tumor control for 67% patients at 8 years. Quality of life and quality of bladder function were satisfactory for 67% of patients.

  8. Predicting the STEM outcomes of academically qualified women: A longitudinal examination of social cognitive career theory

    NASA Astrophysics Data System (ADS)

    Wasson, Jillian Woodford

    There is a well-documented gender disparity in science, technology, engineering, and mathematics (STEM) fields, which has been the focus of research for several decades (i.e., Betz & Hackett, 1981; Ceci & Williams, 2009, 2010; Wang, Eccles, & Kenny, 2013). Questions as to why this is the case are not new; however, with the growing body of research, there seem to be more questions than answers. This study drew primarily from the vocational psychology literature, particularly Social Cognitive Career Theory, building on previous literature in this area by examining differences in career choices made over time by qualified women across different stages in the education-to-career pathway. The results of the present study indicate that among qualified women many of the SCCT personal and contextual variables are relevant to STEM career development. Moreover, findings from the present study support the hypothesis (Lent et al., 1994) that personal, environmental, and behavioral variables affect one another. An important aspect of the SCCT model is the acknowledgment that at any given point in time, certain variables will carry different weight (Lent et al., 1994). The current study provides further support for this and underscores the necessity of understanding and framing career development as a process, unfolding across several developmental stages. These findings, their generalizability, and implications for practice should be carefully considered in the context of several limitations that this sample was influenced by: limitations in reliability and selection of variables, lack of diversity within the sample, as well as the extraneous variables related to overall economic and political backdrop.

  9. Hyperbaric Oxygen Treatment of Chronic Refractory Radiation Proctitis: A Randomized and Controlled Double-Blind Crossover Trial With Long-Term Follow-Up

    SciTech Connect

    Clarke, Richard E. Tenorio, L. M. Catalina; Hussey, James R.; Toklu, Akin S.; Cone, D. Lindsie; Hinojosa, Jose G.; Desai, Samir P.; Dominguez Parra, Luis; Rodrigues, Sylvia D.; Long, Robert J.; Walker, Margaret B.

    2008-09-01

    Purpose: Cancer patients who undergo radiotherapy remain at life-long risk of radiation-induced injury to normal tissues. We conducted a randomized, controlled, double-blind crossover trial with long-term follow-up to evaluate the effectiveness of hyperbaric oxygen for refractory radiation proctitis. Methods and Materials: Patients with refractory radiation proctitis were randomized to hyperbaric oxygen at 2.0 atmospheres absolute (Group 1) or air at 1.1 atmospheres absolute (Group 2). The sham patients were subsequently crossed to Group 1. All patients were re-evaluated by an investigator who was unaware of the treatment allocation at 3 and 6 months and Years 1-5. The primary outcome measures were the late effects normal tissue-subjective, objective, management, analytic (SOMA-LENT) score and standardized clinical assessment. The secondary outcome was the change in quality of life. Results: Of 226 patients assessed, 150 were entered in the study and 120 were evaluable. After the initial allocation, the mean SOMA-LENT score improved in both groups. For Group 1, the mean was lower (p 0.0150) and the amount of improvement nearly twice as great (5.00 vs. 2.61, p = 0.0019). Similarly, Group 1 had a greater portion of responders per clinical assessment than did Group 2 (88.9% vs. 62.5%, respectively; p 0.0009). Significance improved when the data were analyzed from an intention to treat perspective (p = 0.0006). Group 1 had a better result in the quality of life bowel bother subscale. These differences were abolished after the crossover. Conclusion: Hyperbaric oxygen therapy significantly improved the healing responses in patients with refractory radiation proctitis, generating an absolute risk reduction of 32% (number needed to treat of 3) between the groups after the initial allocation. Other medical management requirements were discontinued, and advanced interventions were largely avoided. Enhanced bowel-specific quality of life resulted.

  10. 70 Gy Versus 80 Gy in Localized Prostate Cancer: 5-Year Results of GETUG 06 Randomized Trial;Prostate cancer; Dose escalation; Conformal radiotherapy; Randomized trial

    SciTech Connect

    Beckendorf, Veronique; Guerif, Stephane; Le Prise, Elisabeth; Cosset, Jean-Marc; Bougnoux, Agnes; Chauvet, Bruno; Salem, Naji; Chapet, Olivier; Bourdain, Sylvain; Bachaud, Jean-Marc; Maingon, Philippe; Hannoun-Levi, Jean-Michel; Malissard, Luc; Simon, Jean-Marc; Pommier, Pascal; Hay, Men; Dubray, Bernard; Lagrange, Jean-Leon; Luporsi, Elisabeth; Bey, Pierre

    2011-07-15

    Purpose: To perform a randomized trial comparing 70 and 80 Gy radiotherapy for prostate cancer. Patients and Methods: A total of 306 patients with localized prostate cancer were randomized. No androgen deprivation was allowed. The primary endpoint was biochemical relapse according to the modified 1997-American Society for Therapeutic Radiology and Oncology and Phoenix definitions. Toxicity was graded using the Radiation Therapy Oncology Group 1991 criteria and the late effects on normal tissues-subjective, objective, management, analytic scales (LENT-SOMA) scales. The patients' quality of life was scored using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30-item cancer-specific and 25-item prostate-specific modules. Results: The median follow-up was 61 months. According to the 1997-American Society for Therapeutic Radiology and Oncology definition, the 5-year biochemical relapse rate was 39% and 28% in the 70- and 80-Gy arms, respectively (p = .036). Using the Phoenix definition, the 5-year biochemical relapse rate was 32% and 23.5%, respectively (p = .09). The subgroup analysis showed a better biochemical outcome for the higher dose group with an initial prostate-specific antigen level >15 ng/mL. At the last follow-up date, 26 patients had died, 10 of their disease and none of toxicity, with no differences between the two arms. According to the Radiation Therapy Oncology Group scale, the Grade 2 or greater rectal toxicity rate was 14% and 19.5% for the 70- and 80-Gy arms (p = .22), respectively. The Grade 2 or greater urinary toxicity was 10% at 70 Gy and 17.5% at 80 Gy (p = .046). Similar results were observed using the LENT-SOMA scale. Bladder toxicity was more frequent at 80 Gy than at 70 Gy (p = .039). The quality-of-life questionnaire results before and 5 years after treatment were available for 103 patients with no differences found between the 70- and 80-Gy arms. Conclusion: High-dose radiotherapy provided a

  11. Neutron spin echo study of the dynamics of undercooled selenium

    NASA Astrophysics Data System (ADS)

    Simon, Ch.; Faivre, G.; Zorn, R.; Batallan, F.; Legrand, J. F.

    1992-03-01

    We present neutron spin echo measurements on the structural relaxation of undercooled liquid selenium above glass transition. We find a two-stage relaxation process essentially similar to that generally observed in liquids, except for the fact that the slow-stage characteristic time tau_1 varies with the temperature T more slowly than η(T)/T, where η(T) is the macroscopic viscosity. We interpret this apparent discrepancy with respect to the usually found scaling law as the manifestation of the equilibrium-polymer nature of liquid selenium. On the other hand, the data suggest that the Kohlrausch exponent of the slow stage is temperature dependent. Concerning the rapid stage of the relaxation, we show that a possible alternative to the mode-coupling interpretation is to attribute it to the existence of local inhomogeneities of the density close to the glass transition. Nous présentons des résultats de mesures au spectromètre à écho de spin sur la relaxation structurale du sélenium en surfusion près de la transition vitreuse. Nous trouvons une relaxation en deux étapes, essentiellement conforme à celle trouvée antérieurement dans d'autres liquides, à ceci près que le temps caractéristique tau_1 du stade lent varie avec la température T plus lentement que η(T)/T, où η(T) est la viscosité macroscopique. Nous interprétons cet écart apparent à la loi d'échelle généralement observée comme la manifestation du fait que le sélénium liquide est un polymère d'équilibre. L'analyse des données suggège d'autre part que l'exposant de Kohlrausch du stade lent dépend de la température. Quant au stade rapide de la relaxation, nous montrons qu'il peut être interprété, sans recourir à la théorie du couplage de modes, par l'existance d'hétérogénéités locales de la densité au voisinage de la transition vitreuse.

  12. Martian Mixed Layer during Pathfinder Mission

    NASA Astrophysics Data System (ADS)

    Martinez, G. M.; Valero, F.; Vazquez, L.

    2008-09-01

    In situ measurements of the Martian Planetary Boundary Layer (MPBL) encompass only the sur- face layer. Therefore, in order to fully address the MPBL, it becomes necessary to simulate somehow the behaviour of the martian mixed layer. The small-scale processes that happen in the MPBL cause GCM's ([1], [2]) to describe only partially the turbulent statistics, height, convective scales, etc, of the surface layer and the mixed layer. For this reason, 2D and 3D martian mesoscale models ([4], [5]), and large eddy simulations ([4], [6], [7], [8]) have been designed in the last years. Although they are expected to simulate more accurately the MPBL, they take an extremely expensive compu- tational time. Alternatively, we have derived the main turbu- lent characteristics of the martian mixed layer by using surface layer and mixed layer similarity ([9], [10]). From in situ temperature and wind speed measurements, together with quality-tested simu- lated ground temperature [11], we have character- ized the martian mixed layer during the convective hours of Pathfinder mission Sol 25. Mean mixed layer turbulent statistics like tem- perature variance < σ? >, horizontal wind speed variance < σu,v >, vertical wind speed variance < σw >, viscous dissipation rate < ǫ >, and turbu- lent kinetic energy < e > have been calculated, as well as the mixed layer height zi, and the convective scales of wind w? and temperature θ?. Our values, obtained with negligible time cost, match quite well with some previously obtained results via LES's ([4] and [8]). A comparisson between the above obtained mar- tian values and the typical Earth values are shown in Table 1. Convective velocity scale w doubles its counterpart terrestrial typical value, as it does the mean wind speed variances < σu,v > and < σw >. On the other hand, the temperature scale θ? and the mean temperature variance < σ > are virtually around one order higher on Mars. The limitations of these results concern the va- lidity

  13. Risk and markets for ecosystem services.

    PubMed

    Bendor, Todd K; Riggsbee, J Adam; Doyle, Martin

    2011-12-15

    Market-based environmental regulations (e.g., cap and trade, "payments for ecosystem services") are increasingly common. However, few detailed studies of operating ecosystem markets have lent understanding to how such policies affect incentive structures for improving environmental quality. The largest U.S. market stems from the Clean Water Act provisions requiring ecosystem restoration to offset aquatic ecosystems damaged during development. We describe and test how variations in the rules governing this ecosystem market shift risk between regulators and entrepreneurs to promote ecological restoration. We analyze extensive national scale data to assess how two critical aspects of market structure - (a) the geographic scale of markets and (b) policies dictating the release of credits - affect the willingness of entrepreneurs to enter specific markets and produce credits. We find no discernible relationship between policies attempting to ease market entry and either the number of individual producers or total credits produced. Rather, market entry is primarily related to regional geography (the prevalence of aquatic ecosystems) and regional economic growth. Any improvements to policies governing ecosystem markets require explicit evaluation of the interplay between policy and risk elements affecting both regulators and entrepreneurial credit providers. Our findings extend to emerging, regulated ecosystem markets, including proposed carbon offset mechanisms, biodiversity banking, and water quality trading programs. PMID:22044319

  14. Resolving Presynaptic Structure by Electron Tomography

    PubMed Central

    Perkins, Guy A.; Jackson, Dakota R.; Spirou, George A.

    2016-01-01

    A key goal in neurobiology is to generate a theoretical framework that merges structural, physiological and molecular explanations of brain function. These categories of explanation do not advance in synchrony; advances in one category define new experiments in other categories. For example, the synapse was defined physiologically and biochemically before it was visualized using electron microscopy. Indeed, the original descriptions of synapses in the 1950s were lent credence by the presence of spherical vesicles in presynaptic terminals that were considered to be the substrate for quantal neurotransmission. In the last few decades, our understanding of synaptic function has again been driven by physiological and molecular techniques. The key molecular players for synaptic vesicle structure, mobility and fusion were identified and applications of the patch clamp technique permitted physiological estimation of neurotransmitter release and receptor properties. These advances demand higher resolution structural images of synapses. During the 1990s a second renaissance in cell biology driven by EM was fueled by improved techniques for electron tomography (ET) with the ability to compute virtual images with nm resolution between image planes. Over the last fifteen years, ET has been applied to the presynaptic terminal with special attention to the active zone and organelles of the nerve terminal. In this review, we first summarize the technical improvements that have led to a resurgence in utilization of ET and then we summarize new insights gained by the application of ET to reveal the high-resolution structure of the nerve terminal. PMID:25683026

  15. The center-cut solution.

    PubMed

    Firnstahl, T W

    1993-01-01

    Timothy Firnstahl owns five successful restaurants in Seattle, but he recently came very close to owning none. In the early 1990s, he found himself, like so many restauranteurs, facing rising costs, inefficient management, and a recession. Confronting financial annihilation, Firnstahl had to act quickly: since he had no peripherals to trim, he cut off the head of his company. Remarkably, it worked. Firnstahl's problem was his new and innovative restaurant, Sharps Fresh Roasting. The heart of the Sharps concept was a unique long-roasting technique that made lean, inexpensive meats taste as juicy and delicious as fattier, expensive cuts. The process also lent itself to faster service and lower labor costs. But it wasn't working. Sharps wasn't breaking even, and his other restaurants couldn't make up the difference. He needed a solution fast. Firnstahl got his answer from Mikhail Gorbachev: slash the centralized command and liberate the company. In doing so, he would also transfer virtually all power and responsibility to his line managers. And after five months of intensive study and planning, he accomplished what he set out to do. He fired most of his corporate staff, empowered his restaurant managers with "100% Power and Responsibility," and, finally, undertook a massive promotion campaign. A year later, Sharps Fresh Roasting is the gold mine Firnstahl always believed it could be. He's done away with bureaucracy and turned business around in a down market. All this because his managers are managing themselves. PMID:10126155

  16. Exploring the work lives of adults with serious mental illness from a vocational psychology perspective.

    PubMed

    Millner, Uma Chandrika; Rogers, Erna Sally; Bloch, Philippe; Costa, William; Pritchett, Sharon; Woods, Tracy

    2015-10-01

    Current vocational services for adults with serious mental illness remain largely atheoretical and disconnected from mainstream vocational psychology research and practice. This study explored the perspectives on work of adults with serious mental illness, compared perspectives of young and older adults, and assessed these perspectives for the applicability of a well-established theory of vocational psychology. A national sample of 76 individuals with mental illness engaged in the workforce completed a semistructured questionnaire. We applied the principles of a participatory approach to consensual qualitative research methodology in the study design and data analysis. Results yielded a large number of categories, which clustered under domains representative of the primary constructs of social cognitive career theory (SCCT; Lent, 2013). These domains included the antecedents of self-efficacy, namely, personal accomplishments, vicarious learning, social persuasion, and physical or emotional states as well as additional constructs of outcome expectations, personal goals, and contextual barriers. The SCCT model will likely provide a useful framework to bridge the gap between career development theory and vocational services for individuals with mental illness. PMID:26460981

  17. Investigation of social cognitive career theory for minority recruitment in school psychology.

    PubMed

    Bocanegra, Joel O; Gubi, Aaron A; Cappaert, Kevin J

    2016-06-01

    School psychology trainers have historically struggled to adequately increase the number of professionals from diverse backgrounds. An increase in diverse providers is important in meeting the needs of a burgeoning racial/ethnic minority student population. Previous research suggests that minority undergraduate psychology students have less knowledge and exposure to school psychology than for counseling and clinical psychology, and that students with greater exposure or knowledge of school psychology reported significantly greater choice intentions for school psychology. The purpose of this study is to test the applicability of the Social Cognitive Career Theory (SCCT; Lent, Brown, & Hackett, 1994) in explaining minority undergraduate psychology students' choice intentions for school psychology. This study is an analysis of existing data and is based on a national sample of 283 minority undergraduate psychology students. All instruments used in this study were found to have internal consistency ranging from .83 to .91. Students' learning experiences, self-efficacy, outcome expectations, and choice intentions for school psychology were evaluated by way of a mediator analysis. Results from a path analysis suggest that outcome expectations mediated the relationship between exposure and choice intentions for school psychology. Implications for minority recruitment practices are discussed. (PsycINFO Database Record PMID:27243246

  18. Now we know our AZTs, is it safe for kids and me?

    PubMed

    Parks, V E

    1995-01-01

    The National Institute of Allergies and Infectious Diseases (NIAID) has altered its pediatric HIV study (ACTG 152) to eliminate the AZT only arm because children taking AZT alone were progressing faster to opportunistic infections and death than children in the other drug groups. This has caused similar alterations in other trials using AZT alone, but it has also lent credence to the notion that AZT has little or no benefit used as a single agent in children. Additionally, the ACTG 152 results will most likely mean a stronger emphasis on individualized care that depends less on clinical trial data and more on clinical practice. No clinical trials directly compare to the results of ACTG 152, however. In adults, AZT generally appeared either equivalent or better than the AZT/ddI combination. Several questions about ddI therapy in children, such as dosage tolerance, convenience, cost, and choosing the right therapy for the child, remain unanswered. ACTG 152 results (available in 1995) will not provide all the answers that parents of HIV-infected children will need. There is hope that experts in pediatric HIV infection who previously met to develop anti-HIV and prophylaxis guidelines for children will reconvene in anticipation of final ACTG 152 analysis.

  19. The influence of dust grain morphology on H2 formation and desorption in the interstellar medium

    NASA Astrophysics Data System (ADS)

    Hornekaer, Liv; Baurichter, A.; Petrunin, V. V.; Luntz, A. C.

    2005-01-01

    The formation of molecular hydrogen in interstellar dust and molecular clouds is a key step towards formation of new stars and the development of molecular complexity. Since there is no known effective gas phase route for H2 formation in these regions it is the generally accepted view that H2 is formed on the surface of interstellar dust grains. During recent years laboratory experiments have lent further credence to this view by confirming that H2 can indeed be formed efficiently on various dust grain analog surfaces under interstellar conditions (Katz et al. 1999; Manico et al. 2001; Roser et al. 2002; Hornekaer et al. 2003). These experiments have aimed at identifying the formation mechanism and determining its efficiency, as well as determining how the 4.5 eV which is liberated in the formation process is distributed between grain surface heating and translational and ro-vibrational degrees of freedom of the formed molecule. In the present paper we will briefly review a series of experiments performed by the authors and reported on in Hornekaer et al. (2003) aimed at determining the influence of grain surface morphology on molecular hydrogen formation in the interstellar medium. Furthermore, we will examine the implications of surface morphology on the residence time of molecular hydrogen on grain surfaces.

  20. Altered colonic environment, a possible predisposition to colorectal cancer and colonic inflammatory bowel disease: rationale of dietary manipulation with emphasis on disaccharides.

    PubMed

    Szilagyi, A

    1998-03-01

    A recurrent theme in the schema of pathogenetic mechanisms attributed to colorectal cancer (CRC) and inflammatory bowel disease (IBD) is the interaction between genes and environment. Dietary and other environmental factors, and lower intestinal flora and their chemical interactions occur in the pathogenesis of both. Events at the mucosal surface may be influenced by factors in the luminal environment and by contributions of the host. In addition, both forms of IBD--Crohn's disease (CD) and ulcerative colitis (UC)--have distinctive associated host events. Even within CD and UC, different clinical patterns and prognoses may have different specific host mechanisms. Some of the current putative pathogenetic processes in CRC and IBD are reviewed. Particular attention is given to hypotheses relating to the role of dietetic substances, mainly fibre and dairy products, and how they may affect disease formation. It is argued that within the context of hypotheses proposed for possible beneficial effects of these two dietetic factors, CRC and IBD may be considered together. Further support is lent to arguments that similar and additional hypothetical features ascribed to beneficial effects of fibre may be attributed to disaccharides, lactose and its derivatives, lactulose and lactitol. PMID:9559208

  1. Electron microscopy of virulent phages for Streptococcus lactis.

    PubMed Central

    Tsaneva, K P

    1976-01-01

    Electron microscopic studies were made on eight virulent Streptococcus lactis bacteriophages. These phages were taken as representative of eight host range groups established in a study of 75 phage isolates and 253 hosts (213 S. lactis, 22 S. cremoris, 18 S. diacetilactis). The phages studied were shown to have an isometric hexagonal head and noncontractile tails, usually several times longer than the head diameter. The virus heads were octahedral. The phages investigated represented three morphological types on the basis of head diameter , tail thickness, and tail length. These dimensions were approximately: for type I phages, 63, 172, and 11 nm, respectively; type II, 73, 200, and 20 nm, respectively; and type III, represented here by a single phage, 98, 551, and 12 nm, respectively. The tail surface revealed a different arrangment of the structural subunits which lent a helical appearance to the tails of type I and II phages and a guaffered tube appearance to the tail of type III phage. The number of turns along the tail axis, turn length, axial pitch, and helix angle were: type I, 32, 12 to 13 nm, 7.14 nm, and 11 degrees 43', respectively; type II, 24, 24, to 28 nm, 40.00 nm, and 32 degrees 30', respectively; and type III, 120, 12 nm, and no visible slope towards the axis. The morphology types showed complete correlation with serological groups, but not with groups based on host range pattern. Images PMID:817668

  2. Le système opioïde endogène et l’addiction aux drogues1

    PubMed Central

    Maldonado, Rafael

    2010-01-01

    Résumé L’addiction aux drogues est une maladie psychiatrique chronique qui conduit à d’importantes altérations adaptatives dans les circuits de récompense du cerveau. Plusieurs systèmes de neurotransmission sont impliqués dans ces modifications. Cependant, un des systèmes neurochimiques qui joue un rôle essentiel dans l’addiction est le système opioïde endogène. Les récepteurs opioïdes et les peptides opioïdes endogènes sont très largement présents dans les structures cérébrales qui contrôlent les phénomènes de récompense, en particulier le système mésolimbique. Ces récepteurs et peptides opioïdes participent d’une manière sélective à plusieurs aspects des processus addictifs induits par les opiacés, les cannabinoïdes, les psychostimulants, l’alcool et la nicotine. Cette revue rend compte de l’état actuel des connaissances sur la participation de chaque composante du système opioïde endogène dans les propriétés addictives des différentes drogues. PMID:20176158

  3. ANALYSIS OF SULFONATES IN AQUEOUS SAMPLES BY ION-PAIR LC/ESI-MS/MS WITH IN-SOURCE CID FOR ADDUCT PEAK ELIMINATION

    SciTech Connect

    OUYANG,S.; VAIRAVAMURTHY,M.A.

    1999-06-13

    Determination of low-molecular-weight organic sulfonates (e.g. taurine and cysteic acid) in aqueous solutions is important in many applications of biological, environmental and pharmaceutical sciences. These compounds are difficult to be determined by commonly used reversed-phase liquid chromatographic separation combined with UV-Visible detection because of their high solubility and the lack chromophoric moieties. Here the authors report a method combining ion-pair liquid chromatography and electrospray ionization tandem mass spectrometry (IPLC/ESI-MS/MS)for determining sulfonates. The ability of low-molecular-weight sulfonates to form ion-pairs with quaternary ammonium cations in aqueous solutions allowed LC separation with a C{sub 18} column. Detection of the sulfonates was accomplished with ESI-MS that lends a universal mode of mass detection for polar, water soluble compounds. An in-source collision induced dissociation (CID) was applied to eliminate the adduct peaks in mass spectra. Characteristic marker ions showed in the second stage mass spectra lent a method for identifying sulfonates.

  4. New records of bat ectoparasites (Diptera, Hemiptera and Siphonaptera) from northern Argentina.

    PubMed

    Autino, Analía G; Claps, Guillermo L; Sánchez, Mariano S; Barquez, Rubén M

    2009-01-01

    New species of bat-ectoparasite insects are added to the fauna of Argentina and distributional limits are extended for others, based on information obtained from 21 species of bats collected. New data is reported for the distribution of 23 species of bat ectoparasites, of which 17 belong to the Order Diptera [14 Streblidae: Anastrebla caudiferae Wenzel, Anatrichobius scorzai Wenzel, Aspidoptera phyllostomatis (Perty), Megistopoda aranea (Coquillett), M. proxima (Sèguy), Metelasmus pseudopterus Coquillett, Noctiliostrebla aitkeni Wenzel, N. dubia (Rudow), Paradyschiria fusca Speiser, Paradyschiria sp., Strebla chrotopteri Wenzel, Strebla diaemi Wenzel, Trichobius parasiticus Gervais y Xenotrichobius noctilionis Wenzel, and three Nycteribiidae: Basilia carteri Scott, B. plaumanni Scott y B.neamericana Schuurmans Stekhoven (Jr)], three belong to the Order Siphonaptera [one Ischnopsyllidae: Myodopsylla isidori (Weyenbergh), one Tungidae: Rhynchopsyllus pulex Haller, and one Stephanocircidae: Craneopsylla m. minerva (Rothschild)] and three belong to Order Hemiptera [two Polyctenidae: Hesperoctenes fumarius (Westwood) and H. vicinus Jordan, and one Cimicidae: Latrocimex spectans Lent]. Some records are new for Argentina, while others are new for the provinces of Corrientes, Chaco, Entre Ríos, Jujuy, Misiones and Salta. Also new host-parasite relationships are reported. PMID:19488504

  5. [Sudeck disease].

    PubMed

    Enderle, A; Gregl, A

    1990-12-01

    In 1900, the Hamburg surgeon P.H.M. Sudeck was the first to describe the clinical and radiological symptomatology of the disorder to which he later lent his name. He devoted his scientific career to this disorder, "acute inflammatory atrophy" of bone and soft-tissue as he called it. He elaborated the histology of the disorder with his students and advocated the pathogenic peripheral humoral theory. In later years seven further attempts to explain the pathogenesis were published. The present paper notes that this disorder, which can be divided into three distinct stages, is diagnosed mainly on the basis of clinical factors, above all in the early stage, and that x-rays in the early stages are difficult to differentiate from those of immobilisation osteoporosis since both disorders can manifest as patchy rare fraction and fibrous osteolysis in subchondral bone and old growth plates. Moreover, the author also notes that 10% of all Sudeck cases are not preceded by trauma; these must be understood as spontaneous Sudeck or as Sudeck after distant disturbances. A few sources also refer to Sudeck's dystrophy in the presence of lymphatic congestion. Another, special form of Sudeck's atrophy, is the shoulder-hand syndrome which, however, cannot always be differentiated precisely from rheumatic disorders or dystrophic contractures. PMID:1708182

  6. [Dipetalonema lineage. New attempt at classification].

    PubMed

    Chabaud, A G; Bain, O

    1976-01-01

    Through comparing the morphological evolution to the host range and the geographical distribution we can suggest Dipetalonema sensu-largo may be interpreted as a gondwanian lineage which may have evolved after the three main austral continents drifted apart. Therefore, we propose the following systematic splitting: --Sprattia n.gen., type species: S. venacavincola parasite of Australian Marsupials, which may be related to Litomosa; --Breinlia Yorke and Maplestone, 1926, and Breinlia (Johnstonema) (Yeh, 1957), parasite of Australian Marsupials; --Skrjabinofilaria (Travassos, 1925), parasite of American Marsupials; --Macdonaldius (Khanna, 1933), parasite of American Reptiles; --Dipetalonema (Orihelia) n.sub. gen., type species: D. (O.) anticlava, parasite of Dasypodidae; --Dipetalonema (Acanthocheilonema) (Cobbold, 1870), parasite of Insectivora, Carnivora, Pinnipedia, sometimes Rodents; --Dipetalonema (Molinema) (Freitas and Lent, 1939), parasite of Caviomorpha and Beavers; --Dipetalonema (Loxodontofilaria) (Berghe and Gillain, 1939), parasite of Ethiopian Ungulates; --Dipetalonema (Chenofilaria) (Kou, 1958), parasite of Asiatic Pholidota and Australian Marsupials; --Dipetalonema (Dipetalonema) (Diesing, 1861), parasite of American Primates; --Monanema Anteson, 1968, parasite of Rodents other than Cariomorpha; --Ackertia (Vaz, 1934), parasite of Caviomorpha; --Tetrapetalonema (Sandnema) n.sub.gen., type species: T. (S.) digitata, parasite of Asiatic Insectivora and Primates; --Tetrapetalonema (Tetrapetalonema) (Faust, 1935), parasite of Tupaidae, Platyrhinii, and, sometimes, American Rodents and Carnivora; --Tetrapetalonema (Esslingeria) n. sub.gen., type species: T. (E.) perstans, parasite of African African Anthropoidea and Humans; --Filarissima (Chabaud, 1974), parasite of Caviomorpha.

  7. Predicting the math/science career goals of low-income prospective first-generation college students.

    PubMed

    Garriott, Patton O; Flores, Lisa Y; Martens, Matthew P

    2013-04-01

    The present study used social cognitive career theory (SCCT; Lent, Brown, & Hackett, 1994) to predict the math/science goal intentions of a sample of low-income prospective first-generation college students (N = 305). Structural equation modeling was used to test a model depicting relationships between contextual (i.e., social class, learning experiences, proximal supports and barriers) and person-cognitive (i.e., self-efficacy, outcome expectations, interests, goals) variables as hypothesized in SCCT and based on previous literature on low-income first-generation college students. Results indicated that the hypothesized model provided the best representation of the data. All paths in the model were statistically significant, with the exceptions of paths from self-efficacy to goals, outcome expectations to interests, and perceived barriers to self-efficacy. Bootstrapping procedures revealed that the relationships between social class, self-efficacy, and outcome expectations were mediated through learning experiences. Furthermore, the relationship between social supports and goals was mediated by self-efficacy and interests and the relationships between self-efficacy, outcome expectations, and goals were mediated by interests. Contrary to hypotheses, the relationship between barriers and goals was not mediated by self-efficacy and interests. The hypothesis that proximal contextual supports and barriers would moderate the relationship between interests and goals was not supported. The final model explained 66% and 55% of the variance in math/science interests and goals, respectively. Implications for future research and practice are discussed.

  8. Bioinformatics Identification of Drug Resistance-Associated Gene Pairs in Mycobacterium tuberculosis

    PubMed Central

    Cui, Ze-Jia; Yang, Qing-Yong; Zhang, Hong-Yu; Zhu, Qiang; Zhang, Qing-Ye

    2016-01-01

    Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis (Mtb). Due to the extensive use of anti-tuberculosis drugs and the development of mutations, the emergence and spread of multidrug-resistant tuberculosis is recognized as one of the most dangerous threats to global tuberculosis control. Some single mutations have been identified to be significantly linked with drug resistance. However, the prior research did not take gene-gene interactions into account, and the emergence of transmissible drug resistance is connected with multiple genetic mutations. In this study we use the bioinformatics software GBOOST (The Hong Kong University, Clear Water Bay, Kowloon, Hong Kong, China) to calculate the interactions of Single Nucleotide Polymorphism (SNP) pairs and identify gene pairs associated with drug resistance. A large part of the non-synonymous mutations in the drug target genes that were included in the screened gene pairs were confirmed by previous reports, which lent sound solid credits to the effectiveness of our method. Notably, most of the identified gene pairs containing drug targets also comprise Pro-Pro-Glu (PPE) family proteins, suggesting that PPE family proteins play important roles in the drug resistance of Mtb. Therefore, this study provides deeper insights into the mechanisms underlying anti-tuberculosis drug resistance, and the present method is useful for exploring the drug resistance mechanisms for other microorganisms. PMID:27618895

  9. Un kyste hydatique osseux: une localisation rare au niveau de l’os iliaque

    PubMed Central

    Nhamoucha, Yassine; Alaoui, Othmane; Doumbia, Aliou; Oukhoya, Mohammed; Abdellaoui, Hicham; Tazi, Mohammed; Chater, Lamyae; Atarraf, Karima; Arroud, Mounir; Afifi, Abderahman

    2016-01-01

    L'hydatidose est une affection parasitaire liée au développement chez l'homme de la forme larvaire d'un cestode, à savoir un tænia de très petite taille dénommé Echinococcus Granulosus. Cette anthropozoonose présente une diversité de formes anatomoradiologiques lié aux nombreux aspects topographiques et évolutifs des kystes. L'hydatidose osseuse est rare, elle ne représente que 0,9 à 2,5% de l'ensemble des localisations. Nous rapportons l'observation d'un enfant de 9 ans, qui a été admis chez nous pour une boiterie fébrile avec une masse au niveau de la fosse iliaque droite, révélant un kyste hydatique au dépend de l'os iliaque. Le bilan lésionnel avait objectivé un kyste hydatique de l'os iliaque avec extension aux parties molles adjacentes. Le traitement chirurgical conclu a un kyste surinfecté d'ou la réalisation d'une exérèse chirurgicale du kyste avec drainage. L'ostéopathie hydatique est infiltrante, diffuse, lente et progressive, ce qui rend le diagnostic tardif et qui compromet la qualité du traitement. PMID:27800081

  10. Psychological considerations of man in space: Problems & solutions

    NASA Astrophysics Data System (ADS)

    Kass, J.; Kass, R.; Samaltedinov, I.

    With concrete plans for long duration flight taking form a new impetus is lent to preparing man for this hostile and unnatural environment. Cramped conditions, isolation from family and loved ones, work stress, fear, and incompatibility with fellow crew, are but a few of the problems suffered by astronauts and cosmonauts during their long missions in orbit about the earth. Although criteria for selection of crew is one aspect of attacking the problem, it has not solved it Notwithstanding good selection, team combination, and counselling before flight, problems have still occurred with unwanted consequences. Incompatibility of team members, far from being the exception, has been frequent. This has been detrímental both physiologically and psychologically for the individual as well as for the operational success and safety of the missions. Because problems will inevitably occur in future long duration missions, especially when they are of international and multi-cultural nature, the importance of dealing with them is underlined. This paper takes a different approach towards ameliorating these problems, namely that of psychological group training before a mission.

  11. Ethical considerations of mobile phone use by patients in KwaZulu-Natal: Obstacles for mHealth?

    PubMed Central

    Mars, Maurice

    2014-01-01

    Abstract Background mHealth has the potential to facilitate telemedicine services, particularly in the developing world. Concern has been expressed about the confidentiality of health information that is relayed by mobile phone. Aim We examined the habits and practices of mobile phone use by patients in KwaZulu-Natal, South Africa. Methods We conducted a descriptive survey of two patient populations: 137 urban patients attending private practitioners and 139 patients in remote rural areas attending outpatient departments in Government-funded hospitals. The questionnaire covered several domains: demographics, mobile phone use, privacy and confidentiality and future use for health-related matters. Results Two hundred and seventy-six patients completed the questionnaire. We found that a third of our participants shared their mobile phone with others, 24% lent their phone to others and more than half received health-related messages for other people. Mobile phone theft was common, as was number changing. Thirty-eight percent of the people were not able to afford airtime for more than a week in the past year and 22% of rural patients were unable to keep their phone charged. Mobile phone signal coverage was significantly worse in the rural areas than in urban areas. Conclusion This study highlights the legal and ethical ramifications that these practices and findings will have on mHealth programmes in our setting. Healthcare providers and regulators will need to consider how patients use and manage their mobile phones when developing services and regulations. PMID:26245406

  12. Compression of thick laminated composite beams with initial impact-like damage

    NASA Technical Reports Server (NTRS)

    Breivik, N. L.; Guerdal, Z.; Griffin, O. H., Jr.

    1992-01-01

    While the study of compression after impact of laminated composites has been under consideration for many years, the complexity of the damage initiated by low velocity impact has not lent itself to simple predictive models for compression strength. The damage modes due to non-penetrating, low velocity impact by large diameter objects can be simulated using quasi-static three-point bending. The resulting damage modes are less coupled and more easily characterized than actual impact damage modes. This study includes the compression testing of specimens with well documented initial damage states obtained from three-point bend testing. Compression strengths and failure modes were obtained for quasi-isotropic stacking sequences from 0.24 to 1.1 inches thick with both grouped and interspersed ply stacking. Initial damage prior to compression testing was divided into four classifications based on the type, extent, and location of the damage. These classifications are multiple through-thickness delaminations, isolated delamination, damage near the surface, and matrix cracks. Specimens from each classification were compared to specimens tested without initial damage in order to determine the effects of the initial damage on the final compression strength and failure modes. A finite element analysis was used to aid in the understanding and explanation of the experimental results.

  13. Development of the Multi-Trait Personality Inventory (MTPI): comparison among four Chinese populations.

    PubMed

    Cheung, P C; Conger, A J; Hau, K T; Lew, W J; Lau, S

    1992-12-01

    Anemic approach was adopted to develop a culture-specific instrument for the assessment of Chinese personality. The Multi-Trial Personality Inventory (MTPI) was administered to 1,673 men and 944 women in four major Chinese populations. It was found that Chinese in mainland China, Taiwan, Hong Kong, and the United States possess some common traits deeply rooted in the Chinese culture characterized by Confucian thoughts (e.g., self-discipline and moderation) and some additional traits nurtured by their respective environments. Consequently, findings of this study lent support to the hypothesis that, in spite of superficial discontinuities, there are basic continuities in the personality traits of mainland and overseas Chinese. The cross-cultural differences in personality were examined from a political-social perspective and also explained with a cultural-ecological model. In the development of the MTPI, a new methodology that relies on forming factor-consistent clusters was employed to deal successfully with the problem of complex factor space.

  14. Thanks, but I'm used to better: a relative rank model of gratitude.

    PubMed

    Wood, Alex M; Brown, Gordon D A; Maltby, John

    2011-02-01

    We argue that more help does not necessarily lead to more gratitude. Rather, gratitude depends on how a given instance of help compares with the help that a person is used to receiving. Participants read vignettes detailing an event in which 11 different friends either lent them varying amounts of money or spent varying amounts of time providing help. The amount of gratitude elicited by a given amount of help (e.g., a loan of £36 [about $56] or 49 min help) differed substantially depending on how this amount ranked among the help they were getting from their other friends. Comparison across four experimental conditions suggested that these judgments operated via the same general cognitive mechanisms used to judge other social events and psychophysical stimuli (as outlined by range frequency theory). Although more help does lead to more gratitude, people appear to be sensitive to how that help compares with what others are providing, and experienced gratitude depends on these relative judgments.

  15. Sci—Thur AM: YIS - 11: Estimation of Bladder-Wall Cumulative Dose in Multi-Fraction Image-Based Gynaecological Brachytherapy Using Deformable Point Set Registration

    SciTech Connect

    Zakariaee, R; Brown, C J; Hamarneh, G; Parsons, C A; Spadinger, I

    2014-08-15

    Dosimetric parameters based on dose-volume histograms (DVH) of contoured structures are routinely used to evaluate dose delivered to target structures and organs at risk. However, the DVH provides no information on the spatial distribution of the dose in situations of repeated fractions with changes in organ shape or size. The aim of this research was to develop methods to more accurately determine geometrically localized, cumulative dose to the bladder wall in intracavitary brachytherapy for cervical cancer. The CT scans and treatment plans of 20 cervical cancer patients were used. Each patient was treated with five high-dose-rate (HDR) brachytherapy fractions of 600cGy prescribed dose. The bladder inner and outer surfaces were delineated using MIM Maestro software (MIM Software Inc.) and were imported into MATLAB (MathWorks) as 3-dimensional point clouds constituting the “bladder wall”. A point-set registration toolbox for MATLAB, Coherent Point Drift (CPD), was used to non-rigidly transform the bladder-wall points from four of the fractions to the coordinate system of the remaining (reference) fraction, which was chosen to be the emptiest bladder for each patient. The doses were accumulated on the reference fraction and new cumulative dosimetric parameters were calculated. The LENT-SOMA toxicity scores of these patients were studied against the cumulative dose parameters. Based on this study, there was no significant correlation between the toxicity scores and the determined cumulative dose parameters.

  16. Injury to the lung from cancer therapy: Clinical syndromes, measurable endpoints, and potential scoring systems

    SciTech Connect

    McDonald, S.; Rubin, P.; Phillips, T.L.

    1995-03-30

    Toxicity of the respiratory system is a common side effect and complication of anticancer therapy that can result in significant morbidity. The range of respiratory compromise can extend from acute lethal events to degrees of chronic pulmonary decompensation, manifesting years after the initial cancer therapy. This review examines the anatomic-histologic background of the lung and the normal functional anatomic unit. The pathophysiology of radiation and chemotherapy induced lung injury is discussed as well as the associated clinical syndromes. Radiation tolerance doses and volumes are assessed in addition to chemotherapy tolerance and risk factors and radiation-chemotherapy interactions. There are a variety of measurable endpoints for detection and screening. Because of the wide range of available quantitative tests, it would seem that the measurement of impaired lung function is possible. The development of staging systems for acute and late toxicity is discussed an a new staging system for Late Effects in Normal Tissues :(LENT) is proposed. 115 refs., 2 figs., 9 tabs.

  17. [Natural history and eighteenth-century ideas regarding generation and heredity: Buffon and Bonnet].

    PubMed

    Castañeda, L A

    1995-01-01

    The intellectual course of natural history reveals three conceptual approaches. The first was the taxonomic point of view, where naturalists worked to name and classify the living beings created by God. The second approach was provided by the eighteenth century's philosophical doctrine of mechanism, which lent natural history its method of endeavoring to comprehend the workings of organisms, inasmuch as the world "ran". Calling into question the adequacy of prior message, the third approach argued that living things display characteristics quite distinct from those of non-living matter, making it necessary to understand processes rather than simply decompose phenomena to then analyze them. This inadequacy became apparent at the moment when ideas of generation and heredity ascribed a reproductive history to living things, a history where the act of one fellow creature being formed by another plays an important role in coming to understand the workings of life. The paper analyzes these conceptual approaches from the perspective of Buffon's and Bonnet's ideas on reproduction and heredity, which represented opposite schools of thought: epigenesis and preformation. PMID:16688895

  18. Influence of Social Cognitive and Ethnic Variables on Academic Goals of Underrepresented Students in Science and Engineering: A Multiple-Groups Analysis

    PubMed Central

    Byars-Winston, Angela; Estrada, Yannine; Howard, Christina; Davis, Dalelia; Zalapa, Juan

    2010-01-01

    This study investigated the academic interests and goals of 223 African American, Latino/a, Southeast Asian, and Native American undergraduate students in two groups: biological science and engineering (S/E) majors. Using social cognitive career theory (Lent, Brown, & Hackett, 1994), we examined the relationships of social cognitive variables (math/science academic self-efficacy, math/science outcome expectations), along with the influence of ethnic variables (ethnic identity, other-group orientation) and perceptions of campus climate to their math/science interests and goal commitment to earn an S/E degree. Path analysis revealed that the hypothesized model provided good overall fit to the data, revealing significant relationships from outcome expectations to interests and to goals. Paths from academic self-efficacy to S/E goals and from interests to S/E goals varied for students in engineering and biological science. For both groups, other-group orientation was positively related to self-efficacy and support was found for an efficacy-mediated relationship between perceived campus climate and goals. Theoretical and practical implications of the study’s findings are considered as well as future research directions. PMID:20495610

  19. Multi-resolution voxel phantom modeling: a high-resolution eye model for computational dosimetry

    NASA Astrophysics Data System (ADS)

    Caracappa, Peter F.; Rhodes, Ashley; Fiedler, Derek

    2014-09-01

    Voxel models of the human body are commonly used for simulating radiation dose with a Monte Carlo radiation transport code. Due to memory limitations, the voxel resolution of these computational phantoms is typically too large to accurately represent the dimensions of small features such as the eye. Recently reduced recommended dose limits to the lens of the eye, which is a radiosensitive tissue with a significant concern for cataract formation, has lent increased importance to understanding the dose to this tissue. A high-resolution eye model is constructed using physiological data for the dimensions of radiosensitive tissues, and combined with an existing set of whole-body models to form a multi-resolution voxel phantom, which is used with the MCNPX code to calculate radiation dose from various exposure types. This phantom provides an accurate representation of the radiation transport through the structures of the eye. Two alternate methods of including a high-resolution eye model within an existing whole-body model are developed. The accuracy and performance of each method is compared against existing computational phantoms.

  20. Morphological specializations of baleen whales associated with hydrodynamic performance and ecological niche.

    PubMed

    Woodward, Becky L; Winn, Jeremy P; Fish, Frank E

    2006-11-01

    Feeding behavior, prey type, and habitat appear to be associated with the morphological design of body, fluke, and flippers in baleen whales. Morphometric data from whaling records and recent stranding events were compiled, and morphometric parameters describing the body length, and fluke and flipper dimensions for an "average" blue whale Balaenoptera musculus, humpback whale Megaptera novaeangliae, gray whale Eschrichtius robustus, and right whale Eubalaena glacialis were determined. Body mass, body volume, body surface area, and fluke and flipper surface areas were estimated. The resultant morphological configurations lent themselves to the following classifications based on hydrodynamic principles: fast cruiser, slow cruiser, fast maneuverer, and slow maneuverer. Blue whales have highly streamlined bodies with small, high aspect ratio flippers and flukes for fast efficient cruising in the open ocean. On the other hand, the rotund right whale has large, high aspect ratio flukes for efficient slow speed cruising that is optimal for their continuous filter feeding technique. Humpbacks have large, high aspect ratio flippers and a large, low aspect ratio tail for quick acceleration and high-speed maneuvering which would help them catch their elusive prey, while gray whales have large, low aspect ratio flippers and flukes for enhanced low-speed maneuvering in complex coastal water habitats.

  1. Educational Outreach That Any Project Can Implement on a Limited Budget: Lessons From the KT

    NASA Astrophysics Data System (ADS)

    Mladenov, N.

    2005-12-01

    When projects are faced with a limited budget, providing an educational component can be difficult and often overlooked. The Kalahari Transect (KT) project of 2005, a NASA-funded investigation of hydrologic and nutrient controls on savanna ecosystem productivity, operated under such constraints. Yet with the assistance of in-country contacts in Botswana and Zambia and with interest from US high school teachers, the KT project implemented several successful educational outreach activities. The broad scientific coverage of the wet season field campaign in southern Africa lent itself to a diversity of educational opportunities for students and teachers, including participation in soil and vegetation sampling, spectral measurements, and surveying. Post-campaign educational efforts took advantage of the field experience gained by University of Virginia graduate students and postdocs and allowed for the establishment of a 'Graduate Student Lecture Series' for area high school science classes. Here we present the successes and challenges of 1) preparing and funding US graduate students on international field campaigns, 2) integrating undergraduate students in the host country and in the USA, 3) collaborating with US high school teachers, and 4) planning future collaborations with Batswana and Zambian high school teachers.

  2. Use of two surface analyzers to evaluate the surface roughness of four esthetic restorative materials after polishing.

    PubMed

    Joniot, Sabine; Salomon, Jean Pierre; Dejou, Jacques; Grégoire, Geneviève

    2006-01-01

    This study had two aims: determine how well four esthetic restorative materials lent themselves to polishing and compare the results obtained using two different techniques for evaluating surface roughness. The four materials used were two composites modified by the addition of resin, Dyract AP (Dentsply) and Dyract Flow (Dentsply); one composite designed for posterior restorations, SureFil (Dentsply) and one universal micromatrix composite, Esthet-X (Dentsply). Five test pieces were made with each product by inserting the material into cylindrical molds and polymerizing it layer by layer. A single operator polished the specimens on the same day using the Enhance system (Dentsply) and two aluminum oxide pastes. The surfaces were studied successively by means of two surface analyzers: a high-resolution optical profilometer (Nanosurf 488, SAS Technology) and a mechanical profilometer (Mitutoyo Surftest-SV 402). These measurements gave the mean roughness of the surface (Ra). Ten zones were examined for each specimen, and the specimens were observed under an optical microscope (PMG3 inverted metallographic microscope) at 50x magnification. The qualitative and quantitative analyses of the results showed good surface states for all materials. However, the composites based on nano- and micro-filler technology gave the smoothest surfaces after polishing. A comparison of the values obtained with each method of observation showed that mechanical profilometry tended to show roughness caused by polishing, while optical profilometry brought out roughness due to the structure of the material itself.

  3. Social cognitive determinants of ecstasy use to target in evidence-based interventions: a meta-analytical review

    PubMed Central

    Peters, Gjalt-Jorn Y; Kok, Gerjo; Abraham, Charles

    2008-01-01

    Aims The health hazards and prevalence of ecstasy use have been documented in two decades of research, but no review reporting on potentially modifiable antecedents of use is available. The aim of this study was to integrate systematically research identifying cognitive correlates of ecstasy use. Such research has the potential to identify targets for evidence-based interventions designed to discourage use. Methods The databases PsycINFO and MedLine were searched, inclusion criteria applied to resulting hits, and descendency and ancestry approaches applied to the selected publications. Reported associations between cognitive determinants, including intention to use and ecstasy use measures, were synthesized by calculating a weighted mean effect size, r. Results The pattern of associations lent support both to the theory of planned behaviour (TPB) and the expectancy approach as descriptions of potentially useful determinants. Attitudes were associated most strongly with intention and use, followed by subjective norm and perceived behavioural control. Conclusions Consideration of the strength of associations and the potential modifiability of identified cognitions suggests that evidence-based interventions to discourage ecstasy use should target negative expectancies, perceived behavioural control and anticipated regret, and consider tailoring perceived behavioural control elements. PMID:17999706

  4. Incorporation of Estimated Community Viral Load Before HIV Diagnosis for Enhancing Epidemiologic Investigations: A Comparison Between Men Who Have Sex With Men and Heterosexual Men in Hong Kong.

    PubMed

    Wong, Ngai Sze; Wong, Ka Hing; Wong, Philip K H; Lee, Shui Shan

    2015-10-01

    Currently, no studies have specifically incorporated population-level viral load measures for analyzing temporal trends of HIV infection in the Asia Pacific. With the use of longitudinal data from 950 HIV-infected heterosexual male and 1331 men who have sex with men managed at a major HIV clinic in Hong Kong between 1985 and 2012, viral load changes at population levels were compared. We back-calculated seroconversion year of each diagnosed patient and estimated the population-level viral load under the framework recommended by the Centers for Disease Control and Prevention. Full community viral load, a newly designed measure incorporating diagnosed and undiagnosed HIV-infected patients, was 3 to 8 times higher than community viral load derived from diagnosed patients only. The growth curve of full community viral load was 5 years ahead of other viral load measures, the shape of which lent support to the phenomenon of local transmission of men who have sex with men but not among heterosexual male in the predominantly Chinese HIV community in Hong Kong.

  5. The twopenny library: the book trade, working-class readers, and 'middlebrow' novels in Britain, 1930-42.

    PubMed

    Hilliard, Christopher

    2014-01-01

    Twopenny libraries first appeared in North London in 1930 and quickly spread throughout urban Britain. Their innovation was to dispense with subscription fees and charge per loan. Unlike older commercial libraries such as Mudie's, twopenny libraries served a working-class clientele. Some twopenny libraries were standalone businesses. Many more were sidelines to existing businesses such as tobacconists' and newsagents' shops. Library services could be profitable in their own right, but often their main value to their proprietors was to bring customers into the shop more regularly. Established players in the book trade initially responded to twopenny libraries with alarm, but the threat they posed was limited. Their market was not the same as those of booksellers. Some public librarians made arguments along these lines about the twopenny libraries' impact on public libraries; certainly, the two types of institution coexisted. Twopenny libraries carried a lot of so-called light fiction, but they also lent working-class readers the 'middlebrow' bestsellers of the 1920s and 1930s. The wider significance of the twopenny library lies in the way it problematizes the distinction commonly made between a middle-class public for new hardcover novels and a working-class readership of fiction that appeared in cheap papers and magazines. PMID:24988694

  6. What Is Ego Depletion? Toward a Mechanistic Revision of the Resource Model of Self-Control.

    PubMed

    Inzlicht, Michael; Schmeichel, Brandon J

    2012-09-01

    According to the resource model of self-control, overriding one's predominant response tendencies consumes and temporarily depletes a limited inner resource. Over 100 experiments have lent support to this model of ego depletion by observing that acts of self-control at Time 1 reduce performance on subsequent, seemingly unrelated self-control tasks at Time 2. The time is now ripe, therefore, not only to broaden the scope of the model but to start gaining a precise, mechanistic account of it. Accordingly, in the current article, the authors probe the particular cognitive, affective, and motivational mechanics of self-control and its depletion, asking, "What is ego depletion?" This study proposes a process model of depletion, suggesting that exerting self-control at Time 1 causes temporary shifts in both motivation and attention that undermine self-control at Time 2. The article highlights evidence in support of this model but also highlights where evidence is lacking, thus providing a blueprint for future research. Though the process model of depletion may sacrifice the elegance of the resource metaphor, it paints a more precise picture of ego depletion and suggests several nuanced predictions for future research.

  7. Bioinformatics Identification of Drug Resistance-Associated Gene Pairs in Mycobacterium tuberculosis.

    PubMed

    Cui, Ze-Jia; Yang, Qing-Yong; Zhang, Hong-Yu; Zhu, Qiang; Zhang, Qing-Ye

    2016-01-01

    Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis (Mtb). Due to the extensive use of anti-tuberculosis drugs and the development of mutations, the emergence and spread of multidrug-resistant tuberculosis is recognized as one of the most dangerous threats to global tuberculosis control. Some single mutations have been identified to be significantly linked with drug resistance. However, the prior research did not take gene-gene interactions into account, and the emergence of transmissible drug resistance is connected with multiple genetic mutations. In this study we use the bioinformatics software GBOOST (The Hong Kong University, Clear Water Bay, Kowloon, Hong Kong, China) to calculate the interactions of Single Nucleotide Polymorphism (SNP) pairs and identify gene pairs associated with drug resistance. A large part of the non-synonymous mutations in the drug target genes that were included in the screened gene pairs were confirmed by previous reports, which lent sound solid credits to the effectiveness of our method. Notably, most of the identified gene pairs containing drug targets also comprise Pro-Pro-Glu (PPE) family proteins, suggesting that PPE family proteins play important roles in the drug resistance of Mtb. Therefore, this study provides deeper insights into the mechanisms underlying anti-tuberculosis drug resistance, and the present method is useful for exploring the drug resistance mechanisms for other microorganisms. PMID:27618895

  8. Malignant Tumors of the Nasal Cavity and Paranasal Sinuses: Long-Term Outcome and Morbidity With Emphasis on Hypothalamic-Pituitary Deficiency

    SciTech Connect

    Snyers, An Janssens, Geert; Twickler, Marcel B.; Hermus, Ad R.; Takes, Robert P.; Kappelle, Arnoud C.; Merkx, Matthias A.W.; Dirix, Piet; Kaanders, Johannes H.A.M.

    2009-04-01

    Purpose: To evaluate the long-term outcome after surgery and radiotherapy for patients with sinonasal cancer and assess late toxicity, with special emphasis on hypothalamic-pituitary dysfunction. Methods and Materials: A retrospective analysis of 168 patients treated for sinonasal cancer in a single institute between 1986 and 2006. A more detailed analysis was performed on a subgroup of 76 patients with adenocarcinoma or squamous cell carcinoma treated with curative intent. Long-term survivors were evaluated for late toxicity by a multidisciplinary team using the late effects of normal tissues (LENT SOMA) scoring system. Additional endocrinologic tests were performed for assessment of hypothalamic-pituitary function. Results: Five-year actuarial local control and overall survival rates were 62% and 35% for all patients and 64% and 42% for the subgroup with squamous cell carcinoma and adenocarcinoma. In multivariate analysis, T stage was the only significant factor predicting local relapse (79% at 5 years for T1-T3 vs. 53% for T4; p = 0.006). Sinonasal mucosal melanomas had the highest rate of regional failure (33% at 5 years). Thirteen of 21 patients (62%) evaluated at the late morbidity clinic had hormonal disturbances, of whom 5 (24%) had definitive evidence of hypopituitarism with multiple hormonal deficiencies. Conclusion: Local failure is the dominant cause of treatment failure for patients with sinonasal cancer, with T4 stage the only independent predictor. Because of a high rate of radiation-induced hypopituitarism, we recommend endocrinologic surveillance for these patients.

  9. Ascaridoid nematodes of South American mammals, with a definition of a new genus.

    PubMed

    Sprent, J F

    1982-09-01

    Ascaridoid nematodes occurring in South American mammals are divided into categories based on their possible origin. The affinities are discussed of five species so far known only from the Neotropical Region. Toxocara alienata (Rudolphi 1819) is reported from Nasua rufa socialis, Procyon cancrivorus, and Tayassus torquatus. The specimens from T. torquatus are described and found most closely to resemble Toxocara mackerrasae from south-east Asian and Austrialian rodents. Anisakis insignis from Inia geoffrensis is transferred back to Peritrachelius Diesing, 1851, on account of the structure of the lips and spicules. P. insignis is shown to exhibit remarkable convergence of lip structure with Lagochilascaris turgida from Didelphis marsupialis. Galeiceps longispiculum (Freitas & Lent, 1941) from Pteronura brasiliensis is confirmed as a species distinct from G. cucullus (Linstow, 1899) and G. spinicollis (Baylis, 1923), but G. simiae (Mosgovoy, 1951) is considered to be a synonym of G. spinicollis. An error in the host record of G. spinicollis is corrected from Cercopithecus leucampyx kandti to Lutra maculicollis kivuana. Ascaris dasypodina Baylis, 1922 from armadillos, including Cabassous unicinctus and Tolypeutes matacos, is redescribed and placed in a new genus Bairdascaris. The question is raised as to whether some species in Lagochilascaris, Galeiceps, and Toxocara may have crossed directly by sea from Africa to South America, rather than entering via North America.

  10. UV photography of the earth and the moon

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The fundamental aim of this experiment was the acquisition of ultraviolet photographs of the earth and the moon that could be used to interpret similar imagery of Mars and Venus. Venus shows no markings whatever when viewed in visible light, a phenomenon that is in keeping with its immensely thick atmosphere and perpetual cloud cover, but in the near ultraviolet, the planet exhibits low contrast markings which vary in position and appearance with time. Mars posed just the opposite problem from Venus at wavelengths below 4500 A, Mars shows very little detail, sometimes none at all, whereas at longer wavelengths, the surface is clearly visible. Occasionally observers have reported that this obscuration has lifted and the ground has become visible at the shorter wavelengths as well. Such events have been labeled blue clearings and led to the suggestion that the ultraviolet obscuration was caused by an atmospheric haze. Mariner 6 and 7 observations of Mars failed to find such a haze and lent support to the alternative view that ascribed the absence of detail on UV photographs to a simple lack of contrast between Martian surface features at these wavelengths.

  11. If exposure to aluminium in antiperspirants presents health risks, its content should be reduced.

    PubMed

    Pineau, Alain; Fauconneau, Bernard; Sappino, André-Pascal; Deloncle, Roger; Guillard, Olivier

    2014-04-01

    Since aluminium (Al) pervades our environment, the scientific community has for many years raised concerns regarding its safety in humans. Al is present in numerous cosmetics such as antiperspirants, lipsticks and sunscreens. Al chlorohydrate is the active antiperspirant agent in underarm cosmetics and may constitute for Al a key exposure route to the human body and a potential source of damage. An in vitro study has demonstrated that Al from antiperspirant can be absorbed through viable human stripped skin. The potential toxicity of Al has been clearly shown and recent works convincingly argue that Al could be involved in cancerogenic processes. Nowadays, for example, Al is suspected of being involved in breast cancer. Recent work in cells in culture has lent credence to the hypothesis that this metal could accumulate in the mammary gland and selectively interfere with the biological properties of breast epithelial cells, thereby promoting a cascade of alterations reminiscent of the early phases of malignant transformation. In addition, several studies suggest that the presence of Al in human breast could influence metastatic process. As a consequence, given that the toxicity of Al has been widely recognized and that it is not a physiological component in human tissues, reducing the concentration of this metal in antiperspirants is a matter of urgency.

  12. Proteogenomic Discovery of a Small, Novel Protein in Yeast Reveals a Strategy for the Detection of Unannotated Short Open Reading Frames.

    PubMed

    Yagoub, Daniel; Tay, Aidan P; Chen, Zhiliang; Hamey, Joshua J; Cai, Curtis; Chia, Samantha Z; Hart-Smith, Gene; Wilkins, Marc R

    2015-12-01

    In recent years, proteomic data have contributed to genome annotation efforts, most notably in humans and mice, and spawned a field termed "proteogenomics". Yeast, in contrast with higher eukaryotes, has a small genome, which has lent itself to simpler ORF prediction. Despite this, continual advances in mass spectrometry suggest that proteomics should be able to improve genome annotation even in this well-characterized species. Here we applied a proteogenomics workflow to yeast to identify novel protein-coding genes. Specific databases were generated, from intergenic regions of the genome, which were then queried with MS/MS data. This suggested the existence of several putative novel ORFs of <100 codons, one of which we chose to validate. Synthetic peptides, RNA-Seq analysis, and evidence of evolutionary conservation allowed for the unequivocal definition of a new protein of 78 amino acids encoded on chromosome X, which we dub YJR107C-A. It encodes a new type of domain, which ab initio modeling suggests as predominantly α-helical. We show that this gene is nonessential for growth; however, deletion increases sensitivity to osmotic stress. Finally, from the above discovery process, we discuss a generalizable strategy for the identification of short ORFs and small proteins, many of which are likely to be undiscovered. PMID:26554900

  13. Violin

    NASA Astrophysics Data System (ADS)

    Curtin, Joseph; Rossing, Thomas D.

    The first known violins were built in Italy in the early 1500s. While not much is yet known about the instrument's prior development, European forebears include the rebec and the Renaissance fiddle, which themselves evolved from instruments found in the ancient Eastern world. The violin brought together in a particularly happy way features seen in a variety of earlier stringed instruments. Arched plates increased the stiffness-to-mass ratio of the body, creating a more brilliant sound and helping resist long-term deformation. A pronounced waist gave the bow access to the outermost strings, while the precisely calibrated curves of fingerboard and bridge enabled the strings to be played individually as well as in two-, three-, and even four-part chords. In contrast to the viola da gamba and guitar, the violin's top and back plates overhung the ribs, allowing easy removal for repairs, thus contributing to the instrument's fabled longevity. A graceful outline, harmonious proportions, and the minimal use of ornamentation together lent the violin a timeless beauty - explaining in part why it has resisted significant stylistic modification to this day. For a discussion of historical string instruments, see Chap. 17.

  14. Evaluation of LANDSAT-1 image applications to geologic mapping, structural analysis and mineral resource inventory of South America with special emphasis on the Andes Mountain region

    NASA Technical Reports Server (NTRS)

    Carter, W. D. (Principal Investigator)

    1976-01-01

    The author has identified the following significant results. The discovery of copper mineralization along a lineament mapped in Area 7 (La Paz) has lent credence to the use of LANDSAT 1 data as a basic step in mineral exploration. In Area 9 (Copiapo Region), a number of lineaments were found to be associated with the largest copper deposits of the region. In Area 12 (Magallanes), the identification of what is believed to be a tertiary basin from LANDSAT 1 data has resulted in a new area for petroleum exploration. Band 7 images, as black and white transparencies, were found to be the most useful for geologic interpretation in both tropical vegetated areas and desert regions. Color composites made by the diazochrome process, chromaline process, and from color additive viewers provided additional information. Mosaics of LANDSAT 1 data covering 4 x 6 degrees of latitude and longitude compiled at the 1:1,000,000 scale were found to be an ideal size and format for most users.

  15. Radial Internal Material Handling System (RIMS) for Circular Habitat Volumes

    NASA Technical Reports Server (NTRS)

    Howe, A. Scott; Haselschwardt, Sally

    2012-01-01

    A Radial Internal Material Handling System (RIMS) has been developed to service a circular floor area in variable gravity. On planetary surfaces, pressurized human habitable volumes will require a means to carry heavy equipment between various locations within the volume of the habitat, regardless of the partial gravity (Earth, moon, Mars, etc). On the NASA Habitat Demonstration Unit (HDU), a vertical cylindrical volume, it was determined that a variety of heavy items would need to be carried back and forth from deployed locations to the General Maintenance Work Station (GMWS) when in need of repair, and other equipment may need to be carried inside for repairs, such as rover parts and other external equipment. The vertical cylindrical volume of the HDU lent itself to a circular overhead track and hoist system that allows lifting of heavy objects from anywhere in the habitat to any other point in the habitat interior. In addition, the system is able to hand off lifted items to other material handling systems through the side hatches, such as through an airlock. This paper describes the RIMS system which is scalable for application in a variety of circular habitat volumes.

  16. Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings

    PubMed Central

    2011-01-01

    Considerable interest has been shown in the ability of caloric restriction (CR) to improve multiple parameters of health and to extend lifespan. CR is the reduction of caloric intake - typically by 20 - 40% of ad libitum consumption - while maintaining adequate nutrient intake. Several alternatives to CR exist. CR combined with exercise (CE) consists of both decreased caloric intake and increased caloric expenditure. Alternate-day fasting (ADF) consists of two interchanging days; one day, subjects may consume food ad libitum (sometimes equaling twice the normal intake); on the other day, food is reduced or withheld altogether. Dietary restriction (DR) - restriction of one or more components of intake (typically macronutrients) with minimal to no reduction in total caloric intake - is another alternative to CR. Many religions incorporate one or more forms of food restriction. The following religious fasting periods are featured in this review: 1) Islamic Ramadan; 2) the three principal fasting periods of Greek Orthodox Christianity (Nativity, Lent, and the Assumption); and 3) the Biblical-based Daniel Fast. This review provides a summary of the current state of knowledge related to CR and DR. A specific section is provided that illustrates related work pertaining to religious forms of food restriction. Where available, studies involving both humans and animals are presented. The review includes suggestions for future research pertaining to the topics of discussion. PMID:21981968

  17. Corrosion of structural materials by lead-based reactor coolants.

    SciTech Connect

    Abraham, D. P.; Leibowitz, L.; Maroni, V. A.; McDeavitt, S. M.; Raraz, A. G.

    2000-11-16

    Advanced nuclear reactor design has, in recent years, focused increasingly on the use of heavy-liquid-metal coolants, such as lead and lead-bismuth eutectic. Similarly, programs on accelerator-based transmutation systems have also considered the use of such coolants. Russian experience with heavy-metal coolants for nuclear reactors has lent credence to the validity of this approach. Of significant concern is the compatibility of structural materials with these coolants. We have used a thermal convection-based test method to allow exposure of candidate materials to molten lead and lead-bismuth flowing under a temperature gradient. The gradient was deemed essential in evaluating the behavior of the test materials in that should preferential dissolution of components of the test material occur we would expect dissolution in the hotter regions and deposition in the colder regions, thus promoting material transport. Results from the interactions of a Si-rich mild steel alloy, AISI S5, and a ferritic-martensitic stainless steel, HT-9, with the molten lead-bismuth are presented.

  18. Eltgol acutelly improves airway clearance and reduces static pulmonary volumes in adult cystic fibrosis patients.

    PubMed

    Guimarães, Fernando Silva; Lopes, Agnaldo José; Moço, Vanessa Joaquim Ribeiro; Cavalcanti de Souza, Felipe; Silveira de Menezes, Sara Lúcia

    2014-06-01

    Chest physical therapy techniques are essential in order to reduce the frequency of recurrent pulmonary infections that progressively affect lung function in cystic fibrosis patients. Recently, ELTGOL (L'Expiration Lente Totale Glotte Ouverte en décubitus Latéral) emerged as an inexpensive and easy to perform therapeutic option. The aim of this study was to compare the acute effects of ELTGOL and the Flutter valve in stable adult patients with cystic fibrosis. [Subjects and Methods] This was a randomized, crossover study with a sample of cystic fibrosis outpatients. The subjects underwent two protocols (Flutter Valve and ELTGOL interventions, referred to as ELTGOL and FLUTTER) in a randomized order with a one-week washout interval between them. The main outcomes were pulmonary function variables and expectorated sputum dry weight. [Results] ELTGOL cleared 0.34 g more of secretions than FLUTTER (95% CI 0.11 to 0.57). When comparing the physiological effects of ELTGOL and FLUTTER, the first was superior in improving airway resistance (-0.51 cmH2O/L/s; 95% CI -0.88 to -0.14) and airway conductance (0.016 L/s/cmH2O; 95% CI 0.008 to 0.023). [Conclusion] ELTGOL promoted higher secretion removal and improvement in airway resistance and conductance than the Flutter valve. These techniques were equivalent in reducing the pulmonary hyperinflation and air trapping in cystic fibrosis patients. PMID:25013273

  19. Cytotaxonomy of the Brasiliensis subcomplex and the Triatoma brasiliensis complex (Hemiptera: Reduviidae: Triatominae).

    PubMed

    Alevi, Kaio C C; Rosa, João A; Azeredo-Oliveira, Maria Tercília V

    2014-07-22

    We analyzed the classical cytotaxonomy of the Brasiliensis subcomplex (Triatoma brasiliensis Neiva, T. juazeirensis Costa & Felix, T. melanica Costa, Argolo & Felix, T. melanocephala Neiva & Pinto, T. petrochiae Pinto & Barreto, T. lenti Sherlock & Serafim, T. sherlocki Papa, Jurberg, Carcavallo, Cerqueira & Barata, T. tibiamaculata Pinto and T. vitticeps Stal) and the T. brasiliensis complex (T. b. brasiliensis, T. b. macromelasoma Neiva & Lent, T. juazeirensis, T. melanica and T. sherlocki). The five members of the T. brasiliensis complex share the same cytogenetic characteristics. Merely T. sherlocki show differences in spermatids, which confirms the status of more differentiated member of the complex. T. lenti also presented the same cytogenetic characteristics described for the species of the T. brasiliensis complex, which supports possible grouping of the species as sixth member of the complex, although further analysis as molecular and experimental crosses are needed to corroborate this hypothesis. T. petrochiae, T. vitticeps, T. tibiamaculata and T. melanocephala presented one or more characteristics that allow questioning grouping in the proposed Brasiliensis subcomplex. Thus, we suggested that Brasiliensis subcomplex and T. brasiliensis complex should be constituted by the same triatomines (T. b. brasiliensis, T. b. macromelasoma, T. juazeirensis, T. melanica and T. sherlocki). However, we draw attention to T. lenti and suggest that although new analyzes should be performed, possibly this species is the sixth member of the T. brasiliensis complex. 

  20. Alkaline phosphatase activity in salivary gland cells of Rhodnius neglectus and R. prolixus (Hemiptera, Triatominae).

    PubMed

    Lima-Oliveira, A P M; Alevi, K C C; Anhê, A C B; Azeredo-Oliveira, M T V

    2016-07-29

    Alkaline phosphatase activity was detected in salivary gland cells of the Rhodnius neglectus Lent, 1954, and R. prolixus Stal, 1859, vectors of Trypanosoma cruzi Chagas, 1909 (etiological agent of Chagas disease) and T. rangeli Tejera, 1920 (pathogenic to insect). The Gomori technique was used to demonstrate alkaline phosphatase activity. Alkaline phosphatase activity was observed throughout the entire gland, with an increased activity in the posterior region of the principal gland. In particular, phosphatase activity was found in the nucleolar corpuscles, suggesting a relationship with the rRNA transcription and ribosomal biogenesis. Alkaline phosphatase was also detected in the nuclear membrane and nuclear matrix, suggesting an association with the nucleo-cytoplasmic transport of ribonucleoproteins and the mechanisms of cell cycle and DNA replication, respectively. This study highlights the importance of alkaline phosphatase in the salivary gland of R. prolixus and R. neglectus and emphasizes its importance in secretory activity. Secretory activity is directly involved in hematophagy and, consequently, in development during metamorphosis. The observed presence of alkaline phosphatase suggests its involvement in the production of saliva allowing feeding of these insects that are important vectors of Chagas disease.

  1. Implementing Innovative Technologies Through Lesson Plans: What Kind of Support Do Teachers Prefer?

    NASA Astrophysics Data System (ADS)

    Janssen, Noortje; Lazonder, Ard W.

    2015-12-01

    Lesson plans are a potentially powerful means to facilitate teachers' use of technology in the classroom. This study investigated which supplementary information is preferred by teachers when integrating a new technology into the classroom. Forty-six high school biology teachers (23 pre-service and 23 in-service) received a technology-infused lesson plan and were asked to choose between two sets of support materials that differed with regard to the extensiveness and integration of pedagogical and content information. Based on the technological, pedagogical, and content knowledge (TPACK) framework, pre-service teachers ( n = 23) were expected to prefer the appendix containing extensive and separate information, whereas in-service teachers ( n = 23) were predicted to prefer the succinct and integrated version. Teachers' responses to a forced-choice question confirmed the latter expectation, but lent insufficient support to the former. Semi-structured interviews further showed that the justifications of in-service teachers were generally consistent with the TPACK framework. Most pre-service teachers, by contrast, were future-oriented and preferred support that would help increase their proficiency rather than consolidate their existing knowledge base.

  2. Social cognitive predictors of first- and non-first-generation college students' academic and life satisfaction.

    PubMed

    Garriott, Patton O; Hudyma, Aaron; Keene, Chesleigh; Santiago, Dana

    2015-04-01

    The present study tested Lent's (2004) social-cognitive model of normative well-being in a sample (N = 414) of first- and non-first-generation college students. A model depicting relationships between: positive affect, environmental supports, college self-efficacy, college outcome expectations, academic progress, academic satisfaction, and life satisfaction was examined using structural equation modeling. The moderating roles of perceived importance of attending college and intrinsic goal motivation were also explored. Results suggested the hypothesized model provided an adequate fit to the data while hypothesized relationships in the model were partially supported. Environmental supports predicted college self-efficacy, college outcome expectations, and academic satisfaction. Furthermore, college self-efficacy predicted academic progress while college outcome expectations predicted academic satisfaction. Academic satisfaction, but not academic progress predicted life satisfaction. The structural model explained 44% of the variance in academic progress, 56% of the variance in academic satisfaction, and 28% of the variance in life satisfaction. Mediation analyses indicated several significant indirect effects between variables in the model while moderation analyses revealed a 3-way interaction between academic satisfaction, intrinsic motivation for attending college, and first-generation college student status on life satisfaction. Results are discussed in terms of applying the normative model of well-being to promote first- and non-first-generation college students' academic and life satisfaction.

  3. The twopenny library: the book trade, working-class readers, and 'middlebrow' novels in Britain, 1930-42.

    PubMed

    Hilliard, Christopher

    2014-01-01

    Twopenny libraries first appeared in North London in 1930 and quickly spread throughout urban Britain. Their innovation was to dispense with subscription fees and charge per loan. Unlike older commercial libraries such as Mudie's, twopenny libraries served a working-class clientele. Some twopenny libraries were standalone businesses. Many more were sidelines to existing businesses such as tobacconists' and newsagents' shops. Library services could be profitable in their own right, but often their main value to their proprietors was to bring customers into the shop more regularly. Established players in the book trade initially responded to twopenny libraries with alarm, but the threat they posed was limited. Their market was not the same as those of booksellers. Some public librarians made arguments along these lines about the twopenny libraries' impact on public libraries; certainly, the two types of institution coexisted. Twopenny libraries carried a lot of so-called light fiction, but they also lent working-class readers the 'middlebrow' bestsellers of the 1920s and 1930s. The wider significance of the twopenny library lies in the way it problematizes the distinction commonly made between a middle-class public for new hardcover novels and a working-class readership of fiction that appeared in cheap papers and magazines.

  4. The Association of Academic Health Sciences Libraries Annual Statistics: an exploratory twenty-five-year trend analysis.

    PubMed

    Byrd, Gary D; Shedlock, James

    2003-04-01

    This paper presents an exploratory trend analysis of the statistics published over the past twenty-four editions of the Annual Statistics of Medical School Libraries in the United States and Canada. The analysis focuses on the small subset of nineteen consistently collected data variables (out of 656 variables collected during the history of the survey) to provide a general picture of the growth and changing dimensions of services and resources provided by academic health sciences libraries over those two and one-half decades. The paper also analyzes survey response patterns for U.S. and Canadian medical school libraries, as well as osteopathic medical school libraries surveyed since 1987. The trends show steady, but not dramatic, increases in annual means for total volumes collected, expenditures for staff, collections and other operating costs, personnel numbers and salaries, interlibrary lending and borrowing, reference questions, and service hours. However, when controlled for inflation, most categories of expenditure have just managed to stay level. The exceptions have been expenditures for staff development and travel and for collections, which have both outpaced inflation. The fill rate for interlibrary lending requests has remained steady at about 75%, but the mean ratio of items lent to items borrowed has decreased by nearly 50%.

  5. The pleasures and perils of prophetic advocacy: Henry E. Sigerist and the politics of medical reform.

    PubMed Central

    Fee, E

    1996-01-01

    Henry E. Sigerist, an internationally renowned medical historian, played a surprisingly important and visible role in American medical politics in the 1930s and 1940s. Born in Paris of Swiss parents, he was professor in Leipzig, Germany, before coming to the United States in 1932 as professor of the history of medicine at Johns Hopkins University. Once in America. Sigerist became deeply involved in medical politics and the campaign for national health insurance. He argued that individualized medical practice was outdated and should gradually be superseded by state-run and state-financed health services. National health insurance was but one step in this historical progression. Sigerist thus lent the weight of history itself to the cause of medical care reform. The charming and erudite Sigerist was welcomed by the leaders of academic medicine in America. Soon, he emerged as a spokesman of the left wing of the medical profession, an effective and popular speaker and an impassioned advocate of socialized medicine. This paper traces Sigerist's political ideas and activities, and his contributions toward medical care reform in the United States. Images p1639-a p1642-a PMID:8916536

  6. [The real philanthropic expedition of the smallpox vaccine: monarchy and modernity in 1803].

    PubMed

    Rigau-Pérez, José G

    2004-09-01

    Smallpox resulted in the death of 30 % of those who acquired it, so the preventive method discovered by Edward Jenner (London, 1798) spread very quickly. At the request in 1803 of Carlos IV, king of Spain, his government evaluated offers to carry smallpox vaccine to the colonies. The selected proposal, by doctor Francisco Xavier de Balmis, sought to take the lymph to America and Asia in a chain of arm to arm vaccination of foundlings. The Expedition set sail from Corunna on November 30, 1803, stopped in the Canary Isles, Puerto Rico, and Venezuela and after Caracas (1804) split in two groups. Balmis led some members of the Expedition to Cuba and Mexico. For the trip to the Philippines, in 1805, parents lent their children in exchange for economic compensation and the promise that the boys would be returned home. The Expedition returned to Mexico in August, 1807, but Balmis separately took vaccine to China and returned to Spain. Another contingent of the Expedition, under vice-director José Salvany, took vaccine to what we know as Colombia, Ecuador, Peru and Bolivia. His assistant Manuel Grajales reached the Chilean Patagonia in 1811. This article also comments on three principal themes - the institutional management of the scientific project, the conflicts that characterized its course, and the children's experience. The Vaccine Expedition was a brave and humanitarian endeavor, but also an extraordinary sanitary and administrative success. It was not until the twentieth century that a global eradication campaign eliminated smallpox in the world. PMID:15631178

  7. Active transport of 131I across the blood—brain barrier

    PubMed Central

    Davson, Hugh; Hollingsworth, Jillian R.

    1973-01-01

    The ventricular space of rabbits was perfused with a low-viscosity silicone oil for the purpose of (1) collecting freshly secreted cerebrospinal fluid (c.s.f.) uninfluenced by diffusional exchanges with the brain and (2) studying passage of solutes from the blood into the brain, uncomplicated by exchanges with c.s.f. The freshly secreted c.s.f. appeared as fine droplets suspended in the less dense silicone, and accumulated at the bottom of the collected silicone. Studies on the penetration of 24Na from blood into this fluid indicated that considerable exchanges with the brain had occurred between its secretion and collection, in spite of this method of collection. The second objective was attained, in that the exchanges between the freshly secreted fluid and the brain were quantitatively insufficient to affect the measure of kinetics of uptake by brain from the blood. In consequence, it was possible to demonstrate unequivocally that the increased uptake by brain of 131I, when treated with perchlorate, was due to inhibition of an active process occurring across the blood—brain barrier. Other studies, involving ventriculo-cisternal perfusion with artificial c.s.f., lent further support to this concept. 131I distribution is some 32% of the brain weight, a figure close to the `chloride-space'. PMID:4355804

  8. Risk and markets for ecosystem services.

    PubMed

    Bendor, Todd K; Riggsbee, J Adam; Doyle, Martin

    2011-12-15

    Market-based environmental regulations (e.g., cap and trade, "payments for ecosystem services") are increasingly common. However, few detailed studies of operating ecosystem markets have lent understanding to how such policies affect incentive structures for improving environmental quality. The largest U.S. market stems from the Clean Water Act provisions requiring ecosystem restoration to offset aquatic ecosystems damaged during development. We describe and test how variations in the rules governing this ecosystem market shift risk between regulators and entrepreneurs to promote ecological restoration. We analyze extensive national scale data to assess how two critical aspects of market structure - (a) the geographic scale of markets and (b) policies dictating the release of credits - affect the willingness of entrepreneurs to enter specific markets and produce credits. We find no discernible relationship between policies attempting to ease market entry and either the number of individual producers or total credits produced. Rather, market entry is primarily related to regional geography (the prevalence of aquatic ecosystems) and regional economic growth. Any improvements to policies governing ecosystem markets require explicit evaluation of the interplay between policy and risk elements affecting both regulators and entrepreneurial credit providers. Our findings extend to emerging, regulated ecosystem markets, including proposed carbon offset mechanisms, biodiversity banking, and water quality trading programs.

  9. The Incidence of Sixteenth Century Cosmic Models in Modern Texts

    NASA Astrophysics Data System (ADS)

    Maene, S. A.; Best, J. S.; Usher, P. D.

    1999-12-01

    In the sixteenth century, the bounded cosmological models of Copernicus (1543) and Tycho Brahe (1588), and the unbounded model of Thomas Digges (1576), vied with the bounded geocentric model of Ptolemy (c. 140 AD). The work of the philosopher Giordano Bruno in 1584 lent further support to the Digges model. Despite the eventual acceptance of the unbounded universe, analysis of over 100 modern introductory astronomy texts reveals that these early unbounded models are mentioned infrequently. The ratio of mentions of Digges' model to Copernicus' model has the surprisingly low value of R = 0.08. The philosophical speculation of Bruno receives mention more than twice as often (R = 0.17). The expectation that these early unbounded models warrant inclusion in astronomy texts is supported both by modern hindsight and by the literature of the time. In Shakespeare's "Hamlet" of c. 1601, Prince Hamlet suffers from two transformations. According to the cosmic allegorical model, one transformation changes the bounded geocentricism of Ptolemy to the bounded heliocentricism of Copernicus, while the other completes the change to Digges' model of the infinite universe of suns. This interpretation and the modern world view suggest that both transformations should receive equal mention and thus that the ratio R in introductory texts should be close to unity. This work was supported in part by the NASA West Virginia Space Grant Consortium.

  10. Maslow and the motivation hierarchy: measuring satisfaction of the needs.

    PubMed

    Taormina, Robert J; Gao, Jennifer H

    2013-01-01

    For each of the 5 needs in Maslow's motivational hierarchy (physiological, safety-security, belongingness, esteem, and self-actualization), operational definitions were developed from Maslow's theory of motivation. New measures were created based on the operational definitions (1) to assess the satisfaction of each need, (2) to assess their expected correlations (a) with each of the other needs and (b) with four social and personality measures (i.e., family support, traditional values, anxiety/worry, and life satisfaction), and (3) to test the ability of the satisfaction level of each need to statistically predict the satisfaction level of the next higher-level need. Psychometric tests of the scales conducted on questionnaire results from 386 adult respondents from the general population lent strong support for the validity and reliability of all 5 needs measures. Significant positive correlations among the scales were also found; that is, the more each lower-level need was satisfied, the more the next higher-level need was satisfied. Additionally, as predicted, family support, traditional values, and life satisfaction had significant positive correlations with the satisfaction of all 5 needs, and the anxiety/worry facet of neuroticism had significant negative correlations with the satisfaction of all the needs. Multiple regression analyses revealed that the satisfaction of each higher-level need was statistically predicted by the satisfaction of the need immediately below it in the hierarchy, as expected from Maslow's theory.

  11. Miniaturized and high-throughput assays for analysis of T-cell immunity specific for opportunistic pathogens and HIV.

    PubMed

    Li Pira, Giuseppina; Ivaldi, Federico; Starc, Nadia; Landi, Fabiola; Locatelli, Franco; Rutella, Sergio; Tripodi, Gino; Manca, Fabrizio

    2014-04-01

    Monitoring of antigen-specific T-cell responses is valuable in numerous conditions that include infectious diseases, vaccinations, and opportunistic infections associated with acquired or congenital immune defects. A variety of assays that make use of peripheral lymphocytes to test activation markers, T-cell receptor expression, or functional responses are currently available. The last group of assays calls for large numbers of functional lymphocytes. The number of cells increases with the number of antigens to be tested. Consequently, cells may be the limiting factor, particularly in lymphopenic subjects and in children, the groups that more often require immune monitoring. We have developed immunochemical assays that measure secreted cytokines in the same wells in which peripheral blood mononuclear cells (PBMC) are cultured. This procedure lent itself to miniaturization and automation. Lymphoproliferation and the enzyme-linked immunosorbent spot (ELISPOT) assay have been adapted to a miniaturized format. Here we provide examples of immune profiles and describe a comparison between miniaturized assays based on cytokine secretion or proliferation. We also demonstrate that these assays are convenient for use in testing antigen specificity in established T-cell lines, in addition to analysis of PBMC. In summary, the applicabilities of miniaturization to save cells and reagents and of automation to save time and increase accuracy were demonstrated in this study using different methodological approaches valuable in the clinical immunology laboratory.

  12. Miniaturized and High-Throughput Assays for Analysis of T-Cell Immunity Specific for Opportunistic Pathogens and HIV

    PubMed Central

    Ivaldi, Federico; Starc, Nadia; Landi, Fabiola; Locatelli, Franco; Rutella, Sergio; Tripodi, Gino; Manca, Fabrizio

    2014-01-01

    Monitoring of antigen-specific T-cell responses is valuable in numerous conditions that include infectious diseases, vaccinations, and opportunistic infections associated with acquired or congenital immune defects. A variety of assays that make use of peripheral lymphocytes to test activation markers, T-cell receptor expression, or functional responses are currently available. The last group of assays calls for large numbers of functional lymphocytes. The number of cells increases with the number of antigens to be tested. Consequently, cells may be the limiting factor, particularly in lymphopenic subjects and in children, the groups that more often require immune monitoring. We have developed immunochemical assays that measure secreted cytokines in the same wells in which peripheral blood mononuclear cells (PBMC) are cultured. This procedure lent itself to miniaturization and automation. Lymphoproliferation and the enzyme-linked immunosorbent spot (ELISPOT) assay have been adapted to a miniaturized format. Here we provide examples of immune profiles and describe a comparison between miniaturized assays based on cytokine secretion or proliferation. We also demonstrate that these assays are convenient for use in testing antigen specificity in established T-cell lines, in addition to analysis of PBMC. In summary, the applicabilities of miniaturization to save cells and reagents and of automation to save time and increase accuracy were demonstrated in this study using different methodological approaches valuable in the clinical immunology laboratory. PMID:24477854

  13. Investigation of social cognitive career theory for minority recruitment in school psychology.

    PubMed

    Bocanegra, Joel O; Gubi, Aaron A; Cappaert, Kevin J

    2016-06-01

    School psychology trainers have historically struggled to adequately increase the number of professionals from diverse backgrounds. An increase in diverse providers is important in meeting the needs of a burgeoning racial/ethnic minority student population. Previous research suggests that minority undergraduate psychology students have less knowledge and exposure to school psychology than for counseling and clinical psychology, and that students with greater exposure or knowledge of school psychology reported significantly greater choice intentions for school psychology. The purpose of this study is to test the applicability of the Social Cognitive Career Theory (SCCT; Lent, Brown, & Hackett, 1994) in explaining minority undergraduate psychology students' choice intentions for school psychology. This study is an analysis of existing data and is based on a national sample of 283 minority undergraduate psychology students. All instruments used in this study were found to have internal consistency ranging from .83 to .91. Students' learning experiences, self-efficacy, outcome expectations, and choice intentions for school psychology were evaluated by way of a mediator analysis. Results from a path analysis suggest that outcome expectations mediated the relationship between exposure and choice intentions for school psychology. Implications for minority recruitment practices are discussed. (PsycINFO Database Record

  14. A public health physician named Walter Leser.

    PubMed

    Mello, Guilherme Arantes; Bonfim, José Ruben de Alcântara

    2015-09-01

    A brief review of the career of the public health physician Walter Sidney Pereira Leser, who died in 2004 aged 94. Self-taught, from his 1933 doctoral thesis he became a country reference in the field of statistics and epidemiology, with dozens of studies and supervisions. In the clinical field he is one of the founders of Fleury Laboratory, and participates in the creation of CREMESP. As an academic, Leser was a professor at the Escola de Sociologia e Política de São Paulo, Escola Paulista de Medicina e Faculdade de Farmácia e Odontologia da USP. Also, Leser introduced objective tests in the college entrance examination, and led the creation of CESCEM and Carlos Chagas Foundation. In the Escola Paulista de Medicina he created the first Preventive Medicine Department of the country. As a public official, he was secretary of the State Department of Health of São Paulo between 1967 and 1971 and between 1975 and 1979, responsible for extensive reforms and innovations. Among the most remembered, the creation of sanitary medical career. Throughout this legacy, he lent his name to the "Medal of Honor and Merit Public Health Management" of the State of São Paulo.

  15. NF-κB Signaling Pathway, Inflammation and Colorectal Cancer

    PubMed Central

    Wang, Soly; Liu, Zhanjie; Wang, Lunshan; Zhang, Xiaoren

    2009-01-01

    There is growing evidence for a connection between inflammation and tumor development, and the nuclear factor kappa B (NF-κB), a proinflammatory transcription factor, is hypothesized to promote tumorigenesis. Although the genetic evidence for the hypothesis has been lacking, recent papers have lent credence to this hypothesis. It has been reported that constitutive NF-κB activation in inflammatory bowel diseases (IBDs) increases risk of colorectal cancer (CRC) in the patients with the number of years of active disease. NF-κB activation might induce cellular transformation, mediate cellular proliferation, prevent the elimination of pre-neoplastic and fully malignant cells by up-regulating the anti-apoptosis proteins. Furthermore, NF-κB may contribute to the progression of CRC by regulating the expression of diverse target genes that are involved in cell proliferation (Cyclin D1), angiogenesis (VEGF, IL-8, COX2), and metastasis (MMP9). These findings implicate NF-κB inhibition as an important therapeutic target in CRC. However, due to lack of knowledge about the specific roles of different NF-κB subunits in different stage of carcinogenesis, and compounds to block specific subunits of NF-κB family, it will be a long time before the coming of targeting NF-κB in CRC therapy. PMID:19887045

  16. Electrisation

    PubMed Central

    Chaibdraa, A.; Medjellekh, M.S.; Bentakouk, M.C.

    2009-01-01

    Summary La qualité de la prise en charge en urgence des patients atteints d'accidents d'électrisation dépend du degré de compréhension des données physiopathologiques à l'origine des nombreuses manifestations cliniques, dominées par la mort subite. La connaissance des rôles respectifs des différentes caractéristiques de l'électricité (les ampères tuent, les volts brûlent, le risque potentiellement élevé de traumatisme associé), de l'électrothermie et des mécanismes à l'échelon cellulaire a permis de mieux appréhender son extrême gravité. Les conséquences fonctionnelles, esthétiques et psychologiques, avec de lourdes séquelles, expliquent le caractère multidisciplinaire de la prise en charge au long cours. Face à une morbidité importante, la prévention est fondamentale, en particulier pour les professions exposées et pour ce qui concerne les accidents domestiques chez l'enfant. PMID:21991147

  17. The Cyclic Peptide Ecumicin Targeting ClpC1 Is Active against Mycobacterium tuberculosis In Vivo

    PubMed Central

    Gao, Wei; Kim, Jin-Yong; Anderson, Jeffrey R.; Akopian, Tatos; Hong, Seungpyo; Jin, Ying-Yu; Kandror, Olga; Kim, Jong-Woo; Lee, In-Ae; Lee, Sun-Young; McAlpine, James B.; Mulugeta, Surafel; Sunoqrot, Suhair; Wang, Yuehong; Yang, Seung-Hwan; Yoon, Tae-Mi; Goldberg, Alfred L.; Pauli, Guido F.; Cho, Sanghyun

    2014-01-01

    Drug-resistant tuberculosis (TB) has lent urgency to finding new drug leads with novel modes of action. A high-throughput screening campaign of >65,000 actinomycete extracts for inhibition of Mycobacterium tuberculosis viability identified ecumicin, a macrocyclic tridecapeptide that exerts potent, selective bactericidal activity against M. tuberculosis in vitro, including nonreplicating cells. Ecumicin retains activity against isolated multiple-drug-resistant (MDR) and extensively drug-resistant (XDR) strains of M. tuberculosis. The subcutaneous administration to mice of ecumicin in a micellar formulation at 20 mg/kg body weight resulted in plasma and lung exposures exceeding the MIC. Complete inhibition of M. tuberculosis growth in the lungs of mice was achieved following 12 doses at 20 or 32 mg/kg. Genome mining of lab-generated, spontaneous ecumicin-resistant M. tuberculosis strains identified the ClpC1 ATPase complex as the putative target, and this was confirmed by a drug affinity response test. ClpC1 functions in protein breakdown with the ClpP1P2 protease complex. Ecumicin markedly enhanced the ATPase activity of wild-type (WT) ClpC1 but prevented activation of proteolysis by ClpC1. Less stimulation was observed with ClpC1 from ecumicin-resistant mutants. Thus, ClpC1 is a valid drug target against M. tuberculosis, and ecumicin may serve as a lead compound for anti-TB drug development. PMID:25421483

  18. 'Who is the ideal candidate?': decisions and issues relating to visual neuroprosthesis development, patient testing and neuroplasticity

    NASA Astrophysics Data System (ADS)

    Merabet, Lotfi B.; Rizzo, Joseph F., III; Pascual-Leone, Alvaro; Fernandez, Eduardo

    2007-03-01

    Appropriate delivery of electrical stimulation to intact visual structures can evoke patterned sensations of light in individuals who have been blind for many years. This pivotal finding has lent credibility to the concept of restoring functional vision by artificial means. As numerous groups worldwide pursue human clinical testing with visual prosthetic devices, it is becoming increasingly clear that there remains a considerable gap between the challenges of prosthetic device development and the rehabilitative strategies needed to implement this new technology in patients. An important area of future work will be the development of appropriate pre- and post-implantation measures of performance and establishing candidate selection criteria in order to quantify technical advances, guide future device design and optimize therapeutic success. We propose that the selection of an 'ideal' candidate should also be considered within the context of the variable neuroplastic changes that follow vision loss. Specifically, an understanding of the adaptive and compensatory changes that occur within the brain could assist in guiding the development of post-implantation rehabilitative strategies and optimize behavioral outcomes.

  19. Deaf students and scientists side-by-side: Self-efficacy and modeling in real-world earth science research

    NASA Astrophysics Data System (ADS)

    Jepson, Patricia Jane

    Deaf and hard of hearing students from five high schools were involved in an earth science project on geological faults. Variables of interest were self-efficacy in science and self-efficacy in career decision-making. The influence and characteristics of role models for deaf and hard of hearing students were also examined. Social cognitive career theory (Lent, Brown, & Hackett, 1994) was used as the theoretical base in this mixed method study. The fault curriculum unit was a collaborative project between Geosciences faculty at the University of Massachusetts and SOAR-High, an earth science program coordinated by the Clerc Center at Gallaudet University. Students participated in three interconnected learning components: (a) classroom experiments using a specially designed sandbox unit to model changes that take place in the earth's crust; (b) videoconferences with geoscientists; and (c) a five-day field trip where students, teachers, and scientists worked side-by-side in the field studying faults in Utah. Quantitative and qualitative data focused on science self-efficacy, career decision-making self-efficacy, and the influence of role models. Results suggested that active, student-centered learning activities had a positive impact on science self-efficacy and career decision making self-efficacy.

  20. The fate of a progressive science: the Harvard Fatigue Laboratory, athletes, the science of work and the politics of reform.

    PubMed

    Scheffler, Robin Wolfe

    2011-06-01

    In the early twentieth century, fatigue research marked a site of conflicting scientific, industrial, and cultural understandings of working bodies. Many fatigue researchers understood fatigue to be a physiological fact and allied themselves with Progressive-era reformers in urging industrial regulation. Reformers clashed with advocates of Taylorism, who held that productivity could be perpetually increased through managerial efficiency. Histories of this conflict typically cease with the end of the First World War. I examine the work of the Harvard Fatigue Laboratory in the 1920s and 1930s to explore the impact that the introduction of biochemical methods had on the relationship between science and reform. The Laboratory developed sophisticated techniques to study the blood of exercising individuals. In particular, it found that exercising individuals could attain a biochemically "steady state," or equilibrium, and extrapolated from this to assert that fatigue was psychological, not physiological, in nature. In contrast to Progressive-era research, the Laboratory reached this conclusion through laboratory examination, not of workers, but of Laboratory staff members and champion marathon runners. I present the Laboratory's institutional history, scientific work, and finally how common cultural understandings of athletes and work lent plausibility to its efforts to make authoritative statements about industrial conditions.

  1. A public health physician named Walter Leser.

    PubMed

    Mello, Guilherme Arantes; Bonfim, José Ruben de Alcântara

    2015-09-01

    A brief review of the career of the public health physician Walter Sidney Pereira Leser, who died in 2004 aged 94. Self-taught, from his 1933 doctoral thesis he became a country reference in the field of statistics and epidemiology, with dozens of studies and supervisions. In the clinical field he is one of the founders of Fleury Laboratory, and participates in the creation of CREMESP. As an academic, Leser was a professor at the Escola de Sociologia e Política de São Paulo, Escola Paulista de Medicina e Faculdade de Farmácia e Odontologia da USP. Also, Leser introduced objective tests in the college entrance examination, and led the creation of CESCEM and Carlos Chagas Foundation. In the Escola Paulista de Medicina he created the first Preventive Medicine Department of the country. As a public official, he was secretary of the State Department of Health of São Paulo between 1967 and 1971 and between 1975 and 1979, responsible for extensive reforms and innovations. Among the most remembered, the creation of sanitary medical career. Throughout this legacy, he lent his name to the "Medal of Honor and Merit Public Health Management" of the State of São Paulo. PMID:26331506

  2. INTERLIBRARY LOAN, 1952-62: TEN YEARS OF PROGRESS?

    PubMed

    KEENAN, E L

    1964-01-01

    Although the revised General Interlibrary Loan Code of 1952 was designed to alleviate the "crisis" in interlibrary loan services existing at the time, libraries today find that they are still facing the same problems as they did in 1952, namely, excessive use of large, distant libraries for materials available locally, unverified references, stringent restrictions on the materials lent and their subsequent use, and the rising cost of operating interlibrary loan programs. A brief description of the use and abuse of interlibrary loans at the National Library of Medicine is followed by consideration of the alternatives to the concept of interlibrary loan presently under study in various regions. To relieve the current situation, it is proposed that federal funds be made available to medical and scientific libraries on the basis of the percentage of interlibrary loan transactions handled (2 percent of their total circulation figure), that present lending restrictions on materials be relaxed, that photocopying of articles in lieu of loan of the original be done to a greater extent, and that standardized procedures in handling requests be instituted.

  3. Neuroimaging of Fear-Associated Learning.

    PubMed

    Greco, John A; Liberzon, Israel

    2016-01-01

    Fear conditioning has been commonly used as a model of emotional learning in animals and, with the introduction of functional neuroimaging techniques, has proven useful in establishing the neurocircuitry of emotional learning in humans. Studies of fear acquisition suggest that regions such as amygdala, insula, anterior cingulate cortex, and hippocampus play an important role in acquisition of fear, whereas studies of fear extinction suggest that the amygdala is also crucial for safety learning. Extinction retention testing points to the ventromedial prefrontal cortex as an essential region in the recall of the safety trace, and explicit learning of fear and safety associations recruits additional cortical and subcortical regions. Importantly, many of these findings have implications in our understanding of the pathophysiology of psychiatric disease. Recent studies using clinical populations have lent insight into the changes in regional activity in specific disorders, and treatment studies have shown how pharmaceutical and other therapeutic interventions modulate brain activation during emotional learning. Finally, research investigating individual differences in neurotransmitter receptor genotypes has highlighted the contribution of these systems in fear-associated learning.

  4. [Pathogenesis of diabetic microangiopathy. Fluoroangioretinal observations during monocomponent insulin therapy].

    PubMed

    Anselmetti, G; Antoniotti, V; Barbero, P L; Castellazzi, R; Gamba, S; Bruni, B

    1978-01-01

    Current theories on the pathogenesis of diabetic microangiopathy and their effective therapeutical implications are reviewed. The possible role of insulin antibody production in insulin-treated diabetics concerning development and progression of retinopathy is particularly discussed. Thus the opportunity of a monocomponent (MC) insulin treatment in all newly diagnosed insulin-dependent diabetics is considered. The authors have carried out fluorescein angiography in two groups of subjects with JOD comparable for age, sex, diabetes duration (5-7 years), insulin requirement, metabolic control, absence of diabetic heredity as well as of clinical (ophtalmoscopic) signs of microangiopathy (retinopathy). The first group had been treated from the beginning with MC porcine insulin (Monotard) only; the second one with conventional Lente only. Early fluoroangiographic signs of retinopathy ("pre-retinopathy") as increased capillary filling, ischaemic areas, alterations in capillary permeability, microangioaneurysms, "primary exudation" had to be detected. In 2 out of 10 cases in the first group one isolated sign was found; one or more signs were found in the second group. In the first group the insulin antibody titer (IB) was under or nearly above the detection limit; in the second group insulin antibody titer was significantly positive. These preliminary findings suggest a larger prospective study. PMID:756200

  5. Couches minces de phosphates de titane par voie sol-gel

    NASA Astrophysics Data System (ADS)

    Schmutz, C.; Basset, E.; Barboux, P.

    1993-04-01

    Colloidal solutions of ferroelectrics (KTiOPO4) or ionic conductors (LiTi2(PO4)3) materials have been synthetized. These solutions have been used for thin film synthesis. They are obtained by polycondensation reactions between phosphoric acid esters PO(OH){3-x}(OR)x (with 0 < x < 3 and R = Et, ^nBu, ...) and titanium alkoxides. The ratio POH/Ti and the amount of hydrolysis and the parameters which control the condensation. Nous avons synthétisé des solutions colloïdales de précurseurs de phosphates tels que des ferroélectriques (KTiOPO4) ou des conducteurs ioniques (LiTi2(PO4)3) adaptées au dépôt en couches minces. Elles sont obtenues par des réactions de polycondensation contrôlées entre les esters de l'acide phosphorique PO(OH){3-x}(OR)x (avec 0lent la condensation.

  6. Light and/or atomic beams to detect ultraweak gravitational effects

    NASA Astrophysics Data System (ADS)

    Tartaglia, Angelo; Belfi, Jacopo; Beverini, Nicolò; Di Virgilio, Angela; Ortolan, Antonello; Porzio, Alberto; Ruggiero, Matteo Luca

    2014-06-01

    We shall review the opportunities lent by ring lasers and atomic beams interferometry in order to reveal gravitomagnetic effects on Earth. Both techniques are based on the asymmetric propagation of waves in the gravitational field of a rotating mass; actually the times of flight for co- or counter-rotating closed paths turn out to be different. After discussing properties and limitations of the two approaches we shall describe the proposed GINGER experiment which is being developed for the Gran Sasso National Laboratories in Italy. The experimental apparatus will consist of a three-dimensional array of square rings, 6m × 6m, that is planned to reach a sensitivity in the order of 1prad/√Hertz or better. This sensitivity would be one order of magnitude better than the best existing ring, which is the G-ring in Wettzell, Bavaria, and would allow for the terrestrial detection of the Lense-Thirring effect and possibly of deviations from General Relativity. The possibility of using either the ring laser approach or atomic interferometry in a space mission will also be considered. The technology problems are under experimental study using both the German G-ring and the smaller G-Pisa ring, located at the Gran Sasso.

  7. Development of radiation damage during in-situ Kr++ irradiation of Fesbnd Nisbnd Cr model austenitic steels

    NASA Astrophysics Data System (ADS)

    Desormeaux, M.; Rouxel, B.; Motta, A. T.; Kirk, M.; Bisor, C.; de Carlan, Y.; Legris, A.

    2016-07-01

    In situ irradiations of 15Cr/15Nisbnd Ti and 15Cr/25Nisbnd Ti model austenitic steels were performed at the Intermediate Voltage Electron Microscope (IVEM)-Tandem user Facility (Argonne National Laboratory) at 600 °C using 1 MeV Kr++. The experiment was designed in the framework of cladding development for the GEN IV Sodium Fast Reactors (SFR). It is an extension of previous high dose irradiations on those model alloys at JANNuS-Saclay facility in France, aimed at investigating swelling mechanisms and microstructure evolution of these alloys under irradiation [1]. These studies showed a strong influence of Ni in decreasing swelling. In situ irradiations were used to continuously follow the microstructure evolution during irradiation using both diffraction contrast imaging and recording of diffraction patterns. Defect analysis, including defect size, density and nature, was performed to characterize the evolving microstructure and the swelling. Comparison of 15Cr/15Nisbnd Ti and 15Cr/25Nisbnd Ti irradiated microstructure has lent insight into the effect of nickel content in the development of radiation damage caused by heavy ion irradiation. The results are quantified and discussed in this paper.

  8. [Responding to patients with home mechanical ventilation after the Great East Japan Earthquake and during the planned power outages. How should we be prepared for a future disaster ?].

    PubMed

    Takechi, Yukako

    2011-12-01

    The unprecedented earthquake(magnitude-9 in the Japanese seismic intensity scale)hit off the east coast of Japan on March 11, 2011. Consequently, there were planned power outages in the area nearby Tokyo to avoid massive blackouts caused by a stoppage of Fukushima nuclear plants.Our clinic located in Kawasaki city was also hit by the earthquake(magnitude- 5).During the period of two months(March and April 2011), we had a total of 52 patients with home respiratory care (5-TPPV, 11-NPPV and 36-HOT)at that time.Two out of three 24 hour-TPPV users had no external battery.After the earthquake, there was a 7-hour electricity failure in some areas, and a patient with ASV(adaptive servo ventilator)was living there.Moreover, 3-hour/day power outages were carried out from March 14 to March 28, affecting people's everyday lives. However, the patient had no harmful influences from the power failure because a ventilation company lent us an external battery(4-9 hour life capacity)for the patients, and we were able to avoid an emergency situation caused by the power failure.In conclusion, we ought to be prepared for patients with home mechanical ventilation in the future toward unforeseen large scale power outages.

  9. Expansion of the supernova remnant 3C 10 /Tycho/ and its implications for models of young remnants

    NASA Astrophysics Data System (ADS)

    Strom, R. G.; Goss, W. M.; Shaver, P. A.

    1982-08-01

    The remnant of Tycho Brahe's supernova (3C 10) was observed with the Westerbork telescope at 21 cm in 1971 and 1979, and these measurements have been used to determine the radial expansion rate. The average value obtained is within 0.026 of 0.256 arcsec/yg, with the individual radio and optical data points agreeing well within the errors. The apparent discrepancy in average values is primarily the result of a low expansion speed at the position of the most prominent nebulosity, and this is attributed to deceleration caused by the higher density of material. While the expansion speed only marginally exceeds that predicted by the Sedov solution, the confirmation lent by the optical data suggests a possible real effect. Either the remnant is not yet fully in the adiabatic phase, or the dynamics are being modified by the evaporation of neutral material behind the shock front. It is clear that swept-up material now dominates the dynamics of 3C 10. No significant change in flux density was detected at a level which favors models where particle acceleration/field amplification are occurring over that of simple adiabatic expansion.

  10. A Decade of Short-duration Gamma-ray Burst Afterglows

    NASA Astrophysics Data System (ADS)

    Fong, Wen-fai

    2014-10-01

    The afterglows of gamma-ray bursts (GRBs) provide a unique way to study the explosion properties and sub-parsec environments of these catastrophic events. Indeed, observational campaigns to characterize the afterglows of long GRBs (duration > 2 sec) have lent crucial insight to their massive star progenitors. Short GRBs, which are linked to the mergers of two compact objects, are discovered at a significantly lower rate and have faint afterglows, thus making an understanding of their basic explosion properties more challenging. In this talk, I describe an observational campaign to characterize the afterglows of short GRBs over the past decade, spanning radio to X-ray wavelengths. I use the temporal and spectral behavior of their afterglows to quantify their kinetic energy scales, circumburst densities, and jet opening angles for the first time. I explore any trends between these explosion properties and their host galaxies. Finally, since compact object mergers are the premier candidates for Advanced LIGO detection, I assess the implications for electromagnetic counterparts to gravitational waves.

  11. Understanding the gender gap: Social cognitive changes during an introductory stem course.

    PubMed

    Hardin, Erin E; Longhurst, Melanie O

    2016-03-01

    Despite robust support for the basic theoretical model of social cognitive career theory (Lent, Brown, & Hackett, 1994) and predictions that, for example, increases (or declines) in self-efficacy would lead to subsequent increases (or declines) in interest, there has been surprisingly little longitudinal research that has directly examined the extent to which members of different groups (e.g., women and men) actually do experience changes in critical social-cognitive variables over time early in their curricula in the fields of science, technology, engineering, and mathematics (STEM). Knowing the extent to which such changes occur in typical introductory undergraduate courses is important for targeting interventions to increase persistence of underrepresented groups in STEM. We measured social-cognitive-career-theory-relevant variables near the middle and at the end of the 1st semester of a gateway introductory chemistry course and found that women had lower STEM self-efficacy, coping self-efficacy, and STEM interest than did men, even after controlling for actual course performance. Although there were no detrimental changes across the semester for women or men, men experienced a small but significant increase in their perceived support for pursuing a STEM degree, whereas women did not.

  12. Interaction between heat acclimation and exogenous insulin in brown adipose tissue of rats

    NASA Astrophysics Data System (ADS)

    Ohno, H.; Yamashita, H.; Sato, N.; Habara, Y.; Gasa, S.; Nagasawa, J.; Sato, Y.; Ishikawa, M.; Segawa, M.; Yamamoto, M.

    1992-09-01

    Seventy-one male Wistar strain rats (7 weeks old) were kept at 5, 25, or 34° C, respectively, for 2 weeks with or without insulin administration. Insulin (Novo Lente MC) was given subcutaneously in a dose of 3.62 nmol/125 µl saline per 100 g body weight. An apparent effect of insulin treatment was noted only in heat-exposed rats, resulting in a remarkable gain in inter-scapular brown adipose tissue (BAT) mass of heat-acclimated, insulin-treated rats in terms of weight or weight per unit body weight. The BAT from heat-acclimated, insulin-treated rats had significantly higher levels of protein, DNA, RNA, and triglyceride than BAT from heat-acclimated, saline-treated rats. Therefore, it seems likely that the growth of BAT in heat-acclimated, insulin-treated rats was mostly due to the anabolic effects of insulin. The uncoupling protein mRNA was, however, present in BAT of heat-acclimated, insulin-treated rats at rather a depressed level, explaining a corresponding decrease in cold tolerance. On the other hand, the expression of insulin receptor mRNA was attenuated in BAT of rats from all the insulin-treated groups, possibly due to the down-regulation of insulin. Thus, there appeared to be some linkage among BAT, heat acclimation, and insulin.

  13. Indicators of science, technology, engineering, and math (STEM) career interest among middle school students in the USA

    NASA Astrophysics Data System (ADS)

    Mills, Leila A.

    This study examines middle school students' perceptions of a future career in a science, math, engineering, or technology (STEM) career field. Gender, grade, predispositions to STEM contents, and learner dispositions are examined for changing perceptions and development in career-related choice behavior. Student perceptions as measured by validated measurement instruments are analyzed pre and post participation in a STEM intervention energy-monitoring program that was offered in several U.S. middle schools during the 2009-2010, 2010-2011 school years. A multiple linear regression (MLR) model, developed by incorporating predictors identified by an examination of the literature and a hypothesis-generating pilot study for prediction of STEM career interest, is introduced. Theories on the career choice development process from authors such as Ginzberg, Eccles, and Lent are examined as the basis for recognition of career concept development among students. Multiple linear regression statistics, correlation analysis, and analyses of means are used to examine student data from two separate program years. Study research questions focus on predictive ability, RSQ, of MLR models by gender/grade, and significance of model predictors in order to determine the most significant predictors of STEM career interest, and changes in students' perceptions pre and post program participation. Analysis revealed increases in the perceptions of a science career, decreases in perceptions of a STEM career, increase of the significance of science and mathematics to predictive models, and significant increases in students' perceptions of creative tendencies.

  14. Alkaline phosphatase activity in salivary gland cells of Rhodnius neglectus and R. prolixus (Hemiptera, Triatominae).

    PubMed

    Lima-Oliveira, A P M; Alevi, K C C; Anhê, A C B; Azeredo-Oliveira, M T V

    2016-01-01

    Alkaline phosphatase activity was detected in salivary gland cells of the Rhodnius neglectus Lent, 1954, and R. prolixus Stal, 1859, vectors of Trypanosoma cruzi Chagas, 1909 (etiological agent of Chagas disease) and T. rangeli Tejera, 1920 (pathogenic to insect). The Gomori technique was used to demonstrate alkaline phosphatase activity. Alkaline phosphatase activity was observed throughout the entire gland, with an increased activity in the posterior region of the principal gland. In particular, phosphatase activity was found in the nucleolar corpuscles, suggesting a relationship with the rRNA transcription and ribosomal biogenesis. Alkaline phosphatase was also detected in the nuclear membrane and nuclear matrix, suggesting an association with the nucleo-cytoplasmic transport of ribonucleoproteins and the mechanisms of cell cycle and DNA replication, respectively. This study highlights the importance of alkaline phosphatase in the salivary gland of R. prolixus and R. neglectus and emphasizes its importance in secretory activity. Secretory activity is directly involved in hematophagy and, consequently, in development during metamorphosis. The observed presence of alkaline phosphatase suggests its involvement in the production of saliva allowing feeding of these insects that are important vectors of Chagas disease. PMID:27525888

  15. Maslow and the motivation hierarchy: measuring satisfaction of the needs.

    PubMed

    Taormina, Robert J; Gao, Jennifer H

    2013-01-01

    For each of the 5 needs in Maslow's motivational hierarchy (physiological, safety-security, belongingness, esteem, and self-actualization), operational definitions were developed from Maslow's theory of motivation. New measures were created based on the operational definitions (1) to assess the satisfaction of each need, (2) to assess their expected correlations (a) with each of the other needs and (b) with four social and personality measures (i.e., family support, traditional values, anxiety/worry, and life satisfaction), and (3) to test the ability of the satisfaction level of each need to statistically predict the satisfaction level of the next higher-level need. Psychometric tests of the scales conducted on questionnaire results from 386 adult respondents from the general population lent strong support for the validity and reliability of all 5 needs measures. Significant positive correlations among the scales were also found; that is, the more each lower-level need was satisfied, the more the next higher-level need was satisfied. Additionally, as predicted, family support, traditional values, and life satisfaction had significant positive correlations with the satisfaction of all 5 needs, and the anxiety/worry facet of neuroticism had significant negative correlations with the satisfaction of all the needs. Multiple regression analyses revealed that the satisfaction of each higher-level need was statistically predicted by the satisfaction of the need immediately below it in the hierarchy, as expected from Maslow's theory. PMID:23858951

  16. Rupture utérine spontanée sur léiomyosarcome utérin

    PubMed Central

    Boussouni, Khouloud; Benoulaid, Meryem; Dafiri, Rachida

    2016-01-01

    Les sarcomes utérins sont des cancers rares caractérisés par leur polymorphisme clinique et histologique. Ce sont des tumeurs malignes de mauvais pronostic. Ils se révèlent, généralement, par des symptômes non spécifiques à type de douleurs pelviennes, métrorragies. Un tableau d'abdomen aigu avec hémopneumopéritoine est une présentation rare. Nous rapportons le cas d'un léiomyosarcome utérin qui s'est manifesté par une péritonite aigue généralisée inaugurale chez une femme de 43 ans. Le diagnostic de perforation utérine sur tumeur maligne a été suspecté par l'imagerie préopératoire en urgence (échographie et TDM) et confirmé histologiquement. PMID:27642425

  17. Exophtalmie de l’œil gauche en faveur d'un carcinome adénoide kystique orbitaire: à propos d'un cas

    PubMed Central

    Bouzidi, Adil; Iferkhass, Said; El Abidine Hansali, Zine; Elmallaoui, Mohammed; Laktaoui, Abdelkader

    2015-01-01

    Le Cylindrome orbitaire (carcinome adénoide kystique) est une tumeur maligne d'agressivité locale et d’évolution lente. Sa localisation orbitaire aux dépens des glandes lacrymales est exceptionnelle. Nous rapportons le cas d'un patient de 51 ans consultant pour une exophtalmie gauche non axile irréductible, douloureuse; avec ptosis modéré et baisse d'acuité visuelle. Une biopsie de la tumeur par voie palpébrale supérieure a été faite, en faveur d'un un carcinome adénoïde kystique cribriforme de la glande lacrymale. Après trois mois d'un traitement conservateur chirurgical, une exentération totale a été effectuée suivie d'une radiothérapie complémentaire. Le patient a été revu tout les 3 mois en consultation durant la première année. Sur un recul de six ans, le patient ne présente pas de signe en faveur d'une récidive. PMID:26893802

  18. A comparison of pet and purpose-bred research dog (Canis familiaris) performance on human-guided object-choice tasks.

    PubMed

    Lazarowski, Lucia; Dorman, David C

    2015-01-01

    Several studies have shown that domestic dogs respond to human social cues such as pointing. Some experiments have shown that pet dogs outperformed wolves in following a momentary distal point. These findings have lent support to the hypothesis that domestication is responsible for domestic dogs' ability to utilize human gestures. Other studies demonstrating comparable performance in human-socialized wolves suggest this skill depends on experience with relevant human stimuli. However, domestic dogs lacking thorough exposure to humans are underrepresented in the comparative literature. The goal of this study was to evaluate pet and kennel-reared research domestic dogs on their ability to follow two types of point in an object-choice task. This study used young adult, intact male research dogs (n=11) and a comparison group of pet dogs living in human homes (n=9). We found that while pet dogs followed the momentary distal point above chance levels, research dogs did not. Both groups followed the simpler dynamic proximal point; however, pet dogs outperformed research dogs on this task. Our results indicate that ontogenetic experiences may influence a domestic dog's ability to use human gestures, highlighting the importance of testing different sub-populations of domestic dogs. PMID:25245303

  19. Influence of social cognitive and ethnic variables on academic goals of underrepresented students in science and engineering: a multiple-groups analysis.

    PubMed

    Byars-Winston, Angela; Estrada, Yannine; Howard, Christina; Davis, Dalelia; Zalapa, Juan

    2010-04-01

    This study investigated the academic interests and goals of 223 African American, Latino/a, Southeast Asian, and Native American undergraduate students in two groups: biological science and engineering (S/E) majors. Using social cognitive career theory (Lent, Brown, & Hackett, 1994), we examined the relationships of social cognitive variables (math/science academic self-efficacy, math/science outcome expectations), along with the influence of ethnic variables (ethnic identity, other-group orientation) and perceptions of campus climate to their math/science interests and goal commitment to earn an S/E degree. Path analysis revealed that the hypothesized model provided good overall fit to the data, revealing significant relationships from outcome expectations to interests and to goals. Paths from academic self-efficacy to S/E goals and from interests to S/E goals varied for students in engineering and biological science. For both groups, other-group orientation was positively related to self-efficacy and support was found for an efficacy-mediated relationship between perceived campus climate and goals. Theoretical and practical implications of the study's findings are considered as well as future research directions.

  20. The spatiotemporal organization of cerebellar network activity resolved by two-photon imaging of multiple single neurons

    PubMed Central

    Gandolfi, Daniela; Pozzi, Paolo; Tognolina, Marialuisa; Chirico, Giuseppe; Mapelli, Jonathan; D'Angelo, Egidio

    2014-01-01

    In order to investigate the spatiotemporal organization of neuronal activity in local microcircuits, techniques allowing the simultaneous recording from multiple single neurons are required. To this end, we implemented an advanced spatial-light modulator two-photon microscope (SLM-2PM). A critical issue for cerebellar theory is the organization of granular layer activity in the cerebellum, which has been predicted by single-cell recordings and computational models. With SLM-2PM, calcium signals could be recorded from different network elements in acute cerebellar slices including granule cells (GrCs), Purkinje cells (PCs) and molecular layer interneurons. By combining WCRs with SLM-2PM, the spike/calcium relationship in GrCs and PCs could be extrapolated toward the detection of single spikes. The SLM-2PM technique made it possible to monitor activity of over tens to hundreds neurons simultaneously. GrC activity depended on the number of spikes in the input mossy fiber bursts. PC and molecular layer interneuron activity paralleled that in the underlying GrC population revealing the spread of activity through the cerebellar cortical network. Moreover, circuit activity was increased by the GABA-A receptor blocker, gabazine, and reduced by the AMPA and NMDA receptor blockers, NBQX and APV. The SLM-2PM analysis of spatiotemporal patterns lent experimental support to the time-window and center-surround organizing principles of the granular layer. PMID:24782707

  1. The metaphor of epigenesis: Kant, Blumenbach and Herder.

    PubMed

    Helbig, Daniela; Nassar, Dalia

    2016-08-01

    Over the last few decades, the meaning of the scientific theory of epigenesis and its significance for Kant's critical philosophy have become increasingly central questions. Most recently, scholars have argued that epigenesis is a key factor in the development of Kant's understanding of reason as self-grounding and self-generating. Building on this work, our claim is that Kant appealed to not just any epigenetic theory, but specifically Johann Friedrich Blumenbach's account of generation, and that this appeal must be understood not only in terms of self-organization, but also in terms of the demarcation of a specific domain of inquiry: for Blumenbach, the study of life; for Kant, the study of reason. We argue that Kant adopted this specific epigenetic model as a result of his dispute with Herder regarding the independence of reason from nature. Blumenbach's conception of epigenesis and his separation of a domain of the living from the non-living lent Kant the tools to demarcate metaphysics, and to guard reason against Herder's attempts to naturalize it. PMID:27474190

  2. Job characteristics, recovery experiences and occupational well-being: testing cross-lagged relationships across 1 year.

    PubMed

    Kinnunen, Ulla; Feldt, Taru

    2013-12-01

    The aim of the present study conducted among 274 Finnish employees was to examine the relationships between job characteristics, recovery experiences and occupational well-being across 1 year. We hypothesized that these relationships would follow normal causation, that is, job characteristics at T1 predict recovery experiences (detachment, relaxation, mastery and control at off-job time) and well-being (fatigue at work and work engagement) at T2, and recovery experiences at T1 predict well-being at T2. The structural equation modelling analyses lent support to the hypothesized normal causation model compared with the reversed causation and reciprocal models. However, only the longitudinal relationships between job characteristics and recovery experiences were significant. More specifically, high job demands at T1 predicted poor detachment, relaxation and control during off-job time at T2; and high job resources at T1 predicted high mastery experiences in off-job time at T2. Thus, our study showed that job demands in particular inhibited recovery experiences in the long term, but this was not reflected in employee well-being across 1 year.

  3. Captain Cook's beer: the antiscorbutic use of malt and beer in late 18th century sea voyages.

    PubMed

    Stubbs, Brett J

    2003-01-01

    The custom of allowing British seamen the regular use of fermented liquor is an old one. Ale was a standard article of the sea ration as early as the fourteenth century. By the late eighteenth century, beer was considered to be at once a food (a staple beverage and essential part of the sea diet), a luxury (helping to ameliorate the hardship and irregularity of sea life) and a medicine (conducive to health at sea). In particular, beer and its precursors, wort and malt, were administered with the aim of preventing and curing scurvy. This paper examines the use of malt and beer during late eighteenth century British sea voyages, particularly their use as antiscorbutic agents, focusing on James Cook's three voyages during the period 1768-1780. Cook administered sweet wort (an infusion of malt), beer (prepared from an experimental, concentrated malt extract), and spruce beer (prepared mainly from molasses), among many other items, in his attempts to prevent and to cure scurvy. Despite the inconclusive nature of his own experiments, he reported favourably after his second voyage (1772-1775) on the use of wort as an antiscorbutic sea medicine (for which purpose it is now known to be useless). Cook thereby lent credibility to erroneous medical theories about scurvy, helping to perpetuate the use of ineffective treatments and to delay the discovery of a cure for the disorder. PMID:12810402

  4. Exploring the work lives of adults with serious mental illness from a vocational psychology perspective.

    PubMed

    Millner, Uma Chandrika; Rogers, Erna Sally; Bloch, Philippe; Costa, William; Pritchett, Sharon; Woods, Tracy

    2015-10-01

    Current vocational services for adults with serious mental illness remain largely atheoretical and disconnected from mainstream vocational psychology research and practice. This study explored the perspectives on work of adults with serious mental illness, compared perspectives of young and older adults, and assessed these perspectives for the applicability of a well-established theory of vocational psychology. A national sample of 76 individuals with mental illness engaged in the workforce completed a semistructured questionnaire. We applied the principles of a participatory approach to consensual qualitative research methodology in the study design and data analysis. Results yielded a large number of categories, which clustered under domains representative of the primary constructs of social cognitive career theory (SCCT; Lent, 2013). These domains included the antecedents of self-efficacy, namely, personal accomplishments, vicarious learning, social persuasion, and physical or emotional states as well as additional constructs of outcome expectations, personal goals, and contextual barriers. The SCCT model will likely provide a useful framework to bridge the gap between career development theory and vocational services for individuals with mental illness.

  5. Computerized Techniques for Calibrating Pressure Balances

    NASA Astrophysics Data System (ADS)

    Simpson, D. I.

    1994-01-01

    Pressure balances are generally calibrated by the cross-floating technique, where the forces acting on two similar devices in hydrostatic equilibrium are compared. It is a skilled and time-consuming process which has not previously lent itself to significant automation; computers have mostly been used only to calculate results after measurements have been taken. The objective of the present work was to develop real-time computerized measurement techniques to ease the calibration task, which would fully integrate into a single package with versatile software for calculating and displaying results. The calibration process is now conducted by studying graphical computer displays which derive their inputs from differential-pressure transducers and capacitance or optical displacement sensors. The mass imbalance between oil-operated pressure balances is calculated by interpolating between changes in piston rate-of-fall. Differential-pressure transducers are used to estimate mass imbalances between gas-operated balances, and a quick in situ method for determining their sensitivity has been developed. The new techniques have been successfully applied to a variety of pressure balance designs and substantial reductions in calibration times have been achieved. Reduced levels of scatter have revealed small systematic differences between gauge and absolute modes of operation.

  6. A study of the fracture process and factors that control toughness variability in Charpy V-notch specimens

    NASA Astrophysics Data System (ADS)

    Bouchard, Real

    La presente etude a ete initiee pour developper une comprehension quantitative du processus de rupture avec les facteurs qui controlent la dispersion des mesures de tenacite lorsque des eprouvettes Charpy entaillees en V sont utilisees. Un grand nombre d'essais ont ete realises pour un acier C-Mn: eprouvettes Charpy testees sous impact, eprouvettes Charpy testees en flexion lente, eprouvettes axisymetriques entaillees et sollicitees en traction et essais de tenacite sur eprouvettes prefissurees. Base sur le concept de la statistique de Weibull, l'approche locale developpee par le groupe Beremin a ete utilisee pour decrire la probabilite de rupture par clivage en fonction de la contrainte appliquee aussi bien qu'en fonction de l'energie Charpy obtenue. Le calcul par elements finis a ete realise pour determiner la distribution de la deformation et des contraintes en pointe d'entaille et de fissure. La nouvelle approche introduite decrit bien les resultats experimentaux. Les points d'initiation du clivage ont ete identifies au MEB et par la suite, avec la technique de faisceau d'ions focalise, sectionnes, polis et examines. L'examen de la microstructure sous le point d'initiation revele clairement que le clivage s'initie par un mecanisme d'empilement de dislocations ou les dislocations sont arretees aux joints de grain, aux interfaces de perlite/ferrite ou de perlite qui agissent comme barrieres physiques.

  7. EDITORIAL: Quantum phenomena in Nanotechnology Quantum phenomena in Nanotechnology

    NASA Astrophysics Data System (ADS)

    Loss, Daniel

    2009-10-01

    of quantum cellular automata, a new paradigm for computing as reported by Craig S Lent and colleagues (Lent C S, Tougaw P D, Porod W and Bernstein G H 1993 Nanotechnology 4 49-57). The increasingly sophisticated manipulation of spin has been an enduring theme of research throughout this decade, providing a number of interesting developments such as spin pumping (Cota E, Aguado R, Creffield C E and Platero G 2003 Nanotechnology 14 152-6). The idea of spin qubits, proposed by D Loss and D P DiVincenzo (1998 Phys. Rev. A 57 120), developed into an established option for advancing research in quantum computing and continues to drive fruitful avenues of research, such as the integrated superconductive magnetic nanosensor recently devised by researchers in Italy (Granata C, Esposito E, Vettoliere A, Petti L and Russo M 2008 Nanotechnology 19 275501). The device has a spin sensitivity in units of the Bohr magneton of 100 spin Hz-1/2 and has large potential for applications in the measurement of nanoscale magnetization and quantum computing. The advance of science and technology at the nanoscale is inextricably enmeshed with advances in our understanding of quantum effects. As Nanotechnology celebrates its 20th volume, research into fundamental quantum phenomena continues to be an active field of research, providing fertile pasture for developing nanotechnologies.

  8. Expression-based and co-localization detection of arabinogalactan protein 6 and arabinogalactan protein 11 interactors in Arabidopsis pollen and pollen tubes

    PubMed Central

    2013-01-01

    Background Arabinogalactan proteins (AGPs) are cell wall proteoglycans that have been shown to be important for pollen development. An Arabidopsis double null mutant for two pollen-specific AGPs (agp6 agp11) showed reduced pollen tube growth and compromised response to germination cues in vivo. A microarray experiment was performed on agp6 agp11 pollen tubes to search for genetic interactions in the context of pollen tube growth. A yeast two-hybrid experiment for AGP6 and AGP11 was also designed. Results The lack of two specific AGPs induced a meaningful shift in the gene expression profile. In fact, a high number of genes showed altered expression levels, strengthening the case that AGP6 and AGP11 are involved in complex phenomena. The expression levels of calcium- and signaling-related genes were found to be altered, supporting the known roles of the respective proteins in pollen tube growth. Although the precise nature of the proposed interactions needs further investigation, the putative involvement of AGPs in signaling cascades through calmodulin and protein degradation via ubiquitin was indicated. The expression of stress-, as well as signaling- related, genes was also changed; a correlation that may result from the recognized similarities between signaling pathways in both defense and pollen tube growth. The results of yeast two-hybrid experiments lent further support to these signaling pathways and revealed putative AGP6 and AGP11 interactors implicated in recycling of cell membrane components via endocytosis, through clathrin-mediated endosomes and multivesicular bodies. Conclusions The data presented suggest the involvement of AGP6 and AGP11 in multiple signaling pathways, in particular those involved in developmental processes such as endocytosis-mediated plasma membrane remodeling during Arabidopsis pollen development. This highlights the importance of endosomal trafficking pathways which are rapidly emerging as fundamental regulators of the wall

  9. Putting leadership back into strategy.

    PubMed

    Montgomery, Cynthia A

    2008-01-01

    In recent decades an infusion of economics has lent the study of strategy much needed theory and empirical evidence. Strategy consultants, armed with frameworks and techniques, have stepped forward to help managers analyze their industries and position their companies for strategic advantage. Strategy has come to be seen as an analytical problem to be solved. But, says Montgomery, the Timken Professor of Business Administration at Harvard Business School, the benefits of this rigorous approach have attendant costs: Strategy has become a competitive game plan, separate from the company's larger sense of purpose. The CEO's unique role as arbiter and steward of strategy has been eclipsed. And an overemphasis on sustainable competitive advantage has obscured the importance of making strategy a dynamic tool for guiding the company's development over time. For any company, intelligent guidance requires a clear sense of purpose, of what makes the organization truly distinctive. Purpose, Montgomery says, serves as both a constraint on activity and a guide to behavior. Creativity and insight are key to forging a compelling organizational purpose; analysis alone will never suffice. As the CEO--properly a company's chief strategist--translates purpose into practice, he or she must remain open to the possibility that the purpose itself may need to change. Lou Gerstner did this in the 1990s, when he decided that IBM would evolve to focus on applying technology rather than on inventing it. So did Steve Jobs, when he rescued Apple from a poorly performing strategy and expanded the company into attractive new businesses. Watching over strategy day in and day out is the CEO's greatest opportunity to shape the firm as well as outwit the competition.

  10. Susceptibility genes and overall pathogenesis of inflammatory bowel disease: where do we stand?

    PubMed

    Fiocchi, Claudio

    2009-01-01

    The rapid accumulation of new knowledge on the genes, gene variations and genetic loci associated with both forms of inflammatory bowel disease (IBD), e.g. Crohn's disease (CD) and ulcerative colitis (UC), is shedding new light on the immunopathogenic mechanisms underlying these conditions. After the initial report of the association of NOD2 mutations with ileal CD, a large number of additional genetic variants and loci has been found to be associated with both CD and UC, CD alone and, quite recently, UC-associated variants have also emerged. Much of this progress is due to the use of methods such as genome-wide associations (GWA) based on large numbers of reasonably well-characterized patient groups. Among several others, some of the most pathophysiologically relevant associations reported so far are with gene variants related to innate immunity, autophagy, apoptosis, Th1 and Th17 responses, T cell activation, and immunosuppression. Some of these associations have lent further support to previously construed disease mechanisms or disclosed brand new mechanisms, like in the case of the autophagy pathway. While this much progress is obviously welcome, it also brings new challenges. These include the fact that all the gene mutations uncovered so far only account for a minority of all IBD cases, the variable distribution of gene mutations among worldwide IBD populations, and the still unknown effects of gene-gene and gene-environment interactions. Nevertheless, there is no question that genetic information will be quickly utilized not only for a better understanding of IBD pathogenesis, but it will also soon be incorporated into the armamentarium of better diagnostic and therapeutic tools. PMID:19786745

  11. Are bedtime nutritional strategies effective in preventing nocturnal hypoglycaemia in patients with type 1 diabetes?

    PubMed

    Desjardins, K; Brazeau, A-S; Strychar, I; Rabasa-Lhoret, R

    2014-07-01

    Hypoglycaemia remains the major limiting factor for adequate diabetes control for patients with type 1 diabetes (T1D), especially during the night-time. Although nutritional strategies for nocturnal hypoglycaemia (NH) prevention are regularly suggested in clinical practice, there is no evidence-based recommendation for the usefulness and optimal composition of a bedtime snack. The aim of this narrative review was to analyse the current state of knowledge on nutritional strategies to prevent NH in individuals with T1D. A literature search was conducted, using PubMed and Medline (1946 to 2013); 16 studies were retrieved. Overall, the level of evidence was low. Results indicated that a calibrated bedtime snack based on bedtime blood glucose (BG) level could be effective to reduce NH occurrence for patients treated with human or animal insulin (short-acting combined with lente, ultralente and/or intermediate-acting insulin), but there is no evidence for patients treated with insulin analogues as part of multiple daily injections or insulin pump regimen. Some evidence suggests that including uncooked cornstarch or alanine in the bedtime snack composition could provide some benefits for the prevention of NH. Individualized recommendations of a bedtime snack intake for patients or situations at high risk for NH (long standing diabetes, hypoglycaemia unawareness, prior physical activity, alcohol consumption, bedtime BG close to hypoglycaemia threshold) appear as a prudent recommendation. On the basis of the available evidence, a bedtime snack cannot be recommended systematically but it might be useful if prescribed in an individualized fashion; further research is needed to evaluate these strategies.

  12. Muscimol prevents long-lasting potentiation of dorsal horn field potentials in rats with chronic constriction injury exhibiting decreased levels of the GABA transporter GAT-1.

    PubMed

    Miletic, Gordana; Draganic, Pero; Pankratz, Matthew T; Miletic, Vjekoslav

    2003-09-01

    The inhibitory activity of gamma-aminobutyric acid (GABA) is considered critical in setting the conditions for synaptic plasticity, and many studies support an important role of GABA in the suppression of nociceptive transmission in the dorsal horn. Consequently, any injury-induced modification of the GABA action has the potential to critically modify spinal synaptic plasticity. We have previously reported that chronic constriction injury of the sciatic nerve was accompanied by long-lasting potentiation of superficial spinal dorsal horn field potentials following high-frequency tetanus. In this study we examined whether the GABA-A receptor agonist muscimol would modify post-tetanic responses in rats with chronic constriction injury. In animals exhibiting maximal thermal hyperalgesia as one sign of neuropathic pain 7 days after loose ligation of the sciatic nerve, spinal application of muscimol (5, 10 or 20 microg) before the high-frequency (50 Hz) tetanus produced a long-lasting depression (rather than potentiation) of spinal dorsal horn field potentials. In separate but related Western immunoblot experiments, we also established that the chronic constriction injury was accompanied by significant decreases in the content of the GABA transporter GAT-1. These data demonstrated that GABA-A receptor agonists may effectively influence the expression of long-lasting synaptic plasticity in the spinal dorsal horn, and that an injury-induced loss in GABA transporter content may have contributed to a depletion of GABA from its terminals within the spinal dorsal horn. These data lent further support to the notion that the loss of GABA inhibition may have important consequences for the development of neuropathic pain. PMID:14499453

  13. A brisk walk, compared with being sedentary, reduces attentional bias and chocolate cravings among regular chocolate eaters with different body mass.

    PubMed

    Oh, Hwajung; Taylor, Adrian H

    2013-12-01

    Poor self-regulation of high energy snacking has been linked to weight gain. Physical activity can acutely reduce chocolate consumption and cravings but the effects on attentional bias (AB) are unknown. The study aimed to test the effects of exercise among normal and overweight/obese individuals during temporary and longer abstinence. Participants were 20 normal and 21 overweight regular female chocolate eaters (after 24 h abstinence), and 17 females (after ≥1 week abstinence during Lent). They were randomly assigned to engage in 15 min brisk walking or rest, on separate days. AB was assessed using an adapted dot probe task pre and post-treatment at each session, with chocolate/neutral paired images presented for 200 ms (initial AB; IAB) or 1000 ms (maintained AB; MAB). Chocolate craving was assessed pre, during, immediately after, and 5 min and 10 min after treatment, using a 0-100 visual analogue score. Three-way mixed ANOVAs revealed that there was no significant interaction effect between group (i.e., BMI status, or abstinence status) and condition × time for craving and AB to chocolate cues. Fully repeated 2-way ANOVAS revealed a significant condition × time interaction for IAB (F(1,57)=6.39) and chocolate craving (F(2.34,133.19)=14.44). After exercise IAB (t(57)=2.78, p<0.01) was significantly lower than after the rest condition. Craving was significantly lower than the rest condition at all assessments post-baseline. A short bout of physical activity reduces cravings and AB to chocolate cues, relative to control, irrespective of BMI or abstinence period.

  14. Resistant starches and health.

    PubMed

    Kendall, Cyril W C; Emam, Azadeh; Augustin, Livia S A; Jenkins, David J A

    2004-01-01

    It was initially hypothesized that resistant starches, i.e., starch that enters the colon, would have protective effects on chronic colonic diseases, including reduction of colon cancer risk and in the treatment of ulcerative colitis. Recent studies have confirmed the ability of resistant starch to increase fecal bulk, increase the molar ratio of butyrate in relation to other short-chain fatty acids, and dilute fecal bile acids. However the ability of resistant starch to reduce luminal concentrations of compounds that are damaging to the colonic mucosa, including fecal ammonia, phenols, and N-nitroso compounds, still requires clear demonstration. As such, the effectiveness of resistant starch in preventing or treating colonic diseases remains to be assessed. Nevertheless, there is a fraction of what has been termed resistant (RS1) starch, which enters the colon and acts as slowly digested or lente carbohydrate in the small intestine. Foods in this class are low glycemic index and have been shown to reduce the risk of chronic disease. They have been associated with systemic physiological effects such as reduced postprandial insulin levels and higher HDL cholesterol levels. Consumption of low glycemic index foods has been shown to be related to reductions in risk of coronary heart disease and Type 2 diabetes. Type 2 diabetes has in turn been related to a higher risk of colon cancer. If carbohydrates have a protective role in colon cancer prevention this may lie partly in the systemic effects of low glycemic index foods. The colonic advantages of different carbohydrates, varying in their glycemic index and resistant starch content, therefore, remain to be determined. However, as recent positive research findings continue to mount, there is reason for optimism over the possible health advantages of those resistant starches, which are slowly digested in the small intestine. PMID:15287678

  15. Probing the debromination of the flame retardant decabromodiphenyl ether in sediments of a boreal lake.

    PubMed

    Orihel, Diane M; Bisbicos, Tommy; Darling, Colin T R; Dupuis, Alain P; Williamson, Mary; Muir, Derek C G

    2016-03-01

    After decades of use of polybrominated diphenyl ethers (PBDEs) as flame retardants, a large reservoir of these toxins has accumulated in ecosystems worldwide. The present study used an innovative approach to examine whether the fully brominated PBDE decabromodiphenyl ether (decaBDE) degrades to more toxic congeners in aquatic environments. The authors incubated intact sediment microcosms with high-purity [(13)C]decaBDE in a remote boreal lake to assess its debromination under ambient conditions. Although the addition of [(13)C]decaBDE increased total PBDE concentrations in sediment more than 10-fold, the relative amount of [(13)C]decaBDE in sediment did not change significantly over a 1-mo incubation. However, observation of small quantities of lower-brominated [(13)C]BDEs lent support to the hypothesis that decaBDE is slowly debrominated. The authors observed a significant increase in octaBDEs and nonaBDEs in profundal, but not littoral, sediment over 30 d. A second experiment in which sediment was incubated under different light and oxygen regimes yielded a surprising result-oxygen significantly stimulated the formation of octaBDEs and nonaBDEs. The authors also conducted a large-scale in situ enclosure experiment in which they followed the fate of experimentally added decaBDE in sediment over 26 mo, but that study yielded little evidence of decaBDE debromination. Overall, the authors suggest that the debromination of decaBDE occurs very slowly, if at all, in natural sediment of boreal lakes, in contrast to the rapid degradation kinetics reported by most laboratory-based studies, which are usually conducted by dissolving decaBDE in organic solvents. The findings reinforce the need for field studies on contaminant fate to inform environmental policy decisions. PMID:26332257

  16. The core microprocessor component DiGeorge syndrome critical region 8 (DGCR8) is a nonspecific RNA-binding protein.

    PubMed

    Roth, Braden M; Ishimaru, Daniella; Hennig, Mirko

    2013-09-13

    MicroRNA (miRNA) biogenesis follows a conserved succession of processing steps, beginning with the recognition and liberation of an miRNA-containing precursor miRNA hairpin from a large primary miRNA transcript (pri-miRNA) by the Microprocessor, which consists of the nuclear RNase III Drosha and the double-stranded RNA-binding domain protein DGCR8 (DiGeorge syndrome critical region protein 8). Current models suggest that specific recognition is driven by DGCR8 detection of single-stranded elements of the pri-miRNA stem-loop followed by Drosha recruitment and pri-miRNA cleavage. Because countless RNA transcripts feature single-stranded-dsRNA junctions and DGCR8 can bind hundreds of mRNAs, we explored correlations between RNA binding properties of DGCR8 and specific pri-miRNA substrate processing. We found that DGCR8 bound single-stranded, double-stranded, and random hairpin transcripts with similar affinity. Further investigation of DGCR8/pri-mir-16 interactions by NMR detected intermediate exchange regimes over a wide range of stoichiometric ratios. Diffusion analysis of DGCR8/pri-mir-16 interactions by pulsed field gradient NMR lent further support to dynamic complex formation involving free components in exchange with complexes of varying stoichiometry, although in vitro processing assays showed exclusive cleavage of pri-mir-16 variants bearing single-stranded flanking regions. Our results indicate that DGCR8 binds RNA nonspecifically. Therefore, a sequential model of DGCR8 recognition followed by Drosha recruitment is unlikely. Known RNA substrate requirements are broad and include 70-nucleotide hairpins with unpaired flanking regions. Thus, specific RNA processing is likely facilitated by preformed DGCR8-Drosha heterodimers that can discriminate between authentic substrates and other hairpins.

  17. Patient-Assessed Late Toxicity Rates and Principal Component Analysis After Image-Guided Radiation Therapy for Prostate Cancer

    SciTech Connect

    Skala, Marketa; Rosewall, Tara; Dawson, Laura; Divanbeigi, Lorella; Lockwood, Gina; Thomas, Christopher; Crook, Juanita; Chung, Peter; Warde, Padraig; Catton, Charles . E-mail: charles.catton@rmp.uhn.on.ca

    2007-07-01

    Purpose: The aims of this study were to determine the incidence of patient-assessed late toxicity after high-dose, image-guided radiation therapy in a cohort of men with prostate cancer; and to correlate toxicity with conventional dosimetric parameters and rectal and bladder dose-volume histograms (DVH) reduced using principal component analysis. Methods and Materials: Toxicity questionnaires were sent to 690 men treated for localized prostate cancer to 75.6 Gy or 79.8 Gy using three-dimensional conformal radiation therapy (3DCRT) or intensity-modulated radiation therapy (IMRT) between 1997 and 2003 at the Princess Margaret Hospital. Toxicity was graded according to the modified Radiation Therapy Oncology Group (RTOG)-late effects normal tissue (LENT) scoring system. Late rectal and bladder toxicity scores were dichotomized as < Grade 2 and {>=} Grade 2, and correlated with dosimetric parameters and with the first three principal components of rectal and bladder DVHs. Results: In all, 63% of the patients completed the questionnaire. At a median follow-up of 37 months, the incidence of late rectal toxicity RTOG Grades 1, 2, and 3 was 25.2%, 2.5%, and 0.7% respectively. The incidence of late urinary toxicity RTOG Grade 1, 2, and 3 was 16.5%, 8.8%, and 0.9% respectively. Maintenance of erectile function sufficient for intercourse was reported in 68%. No dosimetric parameter analyzed, including principal component analysis reduction of DVHs, correlated with late toxicity. Conclusions: Postal questionnaire was effective for collection of patient-assessed late toxicity data. The incidence of late toxicity was low, with a lack of correlation to dosimetric parameters. We attribute this to the use of conformal techniques and daily image guidance.

  18. Sécurité de la plus récente classe d’antagonistes des opioïdes durant la grossesse

    PubMed Central

    Poon, Shirley; Pupco, Anna; Koren, Gideon; Bozzo, Pina

    2014-01-01

    Résumé Question J’ai une patiente dont 6 semaines de grossesse viennent d’être confirmées. Depuis 6 mois, elle suit une thérapie pour une dépendance aux opioïdes à l’aide d’une combinaison de buprénorphine et de naloxone. Devrais-je m’inquiéter qu’elle ait été exposée à cette combinaison de médicaments jusqu’à ce stade de sa grossesse? Faudrait-il que je change sa médication pour de la méthadone maintenant qu’elle est enceinte? Réponse Les données limitées sur l’exposition à la buprénorphine durant la grossesse ne révèlent pas d’augmentation du risque de résultats indésirables chez le nouveau-né. Il y a peu de données sur la naloxone durant la grossesse; par ailleurs, on ne s’attendrait pas à ce que l’administration par voie orale soit associée avec un risque accru de résultats de grossesse défavorables. On conseille aux médecins qui traitent des femmes enceintes ou qui deviennent enceintes et dont l’état est stable en prenant une thérapie à la buprénorphine et naloxone de continuer ce traitement mais d’envisager une transition à une monothérapie à la buprénorphine.

  19. Dose Effect Relationship for Late Side Effects of the Rectum and Urinary Bladder in Magnetic Resonance Image-Guided Adaptive Cervix Cancer Brachytherapy

    SciTech Connect

    Georg, Petra; Poetter, Richard; Georg, Dietmar; Lang, Stefan; Dimopoulos, Johannes C.A.; Sturdza, Alina E.; Berger, Daniel; Kirisits, Christian; Doerr, Wolfgang

    2012-02-01

    Purpose: To establish dose-response relationships for late side effects of the rectum and bladder in cervix cancer patients after magnetic resonance image-guided adaptive brachytherapy (IGABT). Methods and Materials: A cohort of 141 patients was treated with 45 to 50.4 Gy with or without cisplatin plus 4 fractions of 7 Gy IGABT. Doses for the most exposed 2, 1, and 0.1-cm{sup 3} (D{sub 2cc}, D{sub 1cc}, D{sub 0.1cc}) volumes of the rectum and bladder were converted into the equivalent dose in 2 Gy fractions (EQD2), using a linear quadratic model ({alpha}/{beta} = 3 Gy). Late side effects were prospectively assessed (using late effects in normal tissues subjective, objective, management and analytic [LENT SOMA]) scales. Dose-response relationships were determined by logit analyses. Results: Eleven patients developed rectal side effects, and 23 patients had urinary side effects. A significant dose effect was found for all rectal dose-volume histogram (DVH) parameters for patients with side effect grades of 1 to 4 but was only significant for D{sub 2cc} and D{sub 1cc} for grades {>=}2. The ED10 values for D{sub 2cc} were 73 Gy for grades 1 to 4 and 78 Gy for grades 2 to 4 rectal morbidity. For bladder side effects, a significant dose effect was shown for all DVH parameters for complication grades {>=}2; the respective ED10 was 101 Gy. Conclusions: Well-defined dose-response curves could be established for D{sub 2cc} in the rectum and the urinary bladder.

  20. Entitativity and intergroup bias: How belonging to a cohesive group allows people to express their prejudices.

    PubMed

    Effron, Daniel A; Knowles, Eric D

    2015-02-01

    We propose that people treat prejudice as more legitimate when it seems rationalistic-that is, linked to a group's pursuit of collective interests. Groups that appear to be coherent and unified wholes (entitative groups) are most likely to have such interests. We thus predicted that belonging to an entitative group licenses people to express prejudice against outgroups. Support for this idea came from 3 correlational studies and 5 experiments examining racial, national, and religious prejudice. The first 4 studies found that prejudice and discrimination seemed more socially acceptable to third parties when committed by members of highly entitative groups, because people could more easily explain entitative groups' biases as a defense of collective interests. Moreover, ingroup entitativity only lent legitimacy to outgroup prejudice when an interests-based explanation was plausible-namely, when the outgroup could possibly threaten the ingroup's interests. The last 4 studies found that people were more willing to express private prejudices when they perceived themselves as belonging to an entitative group. Participants' perceptions of their own race's entitativity were associated with a greater tendency to give explicit voice to their implicit prejudice against other races. Furthermore, experimentally raising participants' perceptions of ingroup entitativity increased explicit expressions of outgroup prejudice, particularly among people most likely to privately harbor such prejudices (i.e., highly identified group members). Together, these findings demonstrate that entitativity can lend a veneer of legitimacy to prejudice and disinhibit its expression. We discuss implications for intergroup relations and shifting national demographics. (PsycINFO Database Record (c) 2015 APA, all rights reserved). PMID:25603374

  1. Self-other relations in social development and autism: multiple roles for mirror neurons and other brain bases.

    PubMed

    Williams, Justin H G

    2008-04-01

    Mirror neuron system dysfunction may underlie a self-other matching impairment, which has previously been suggested to account for autism. Embodied Cognition Theory, which proposes that action provides a foundation for cognition has lent further credence to these ideas. The hypotheses of a self-other matching deficit and impaired mirror neuron function in autism have now been well supported by studies employing a range of methodologies. However, underlying mechanisms require further exploration to explain how mirror neurons may be involved in attentional and mentalizing processes. Impairments in self-other matching and mirror neuron function are not necessarily inextricably linked and it seems possible that different sub-populations of mirror neurons, located in several regions, contribute differentially to social cognitive functions. It is hypothesized that mirror neuron coding for action-direction may be required for developing attentional sensitivity to self-directed actions, and consequently for person-oriented, stimulus-driven attention. Mirror neuron networks may vary for different types of social learning such as "automatic" imitation and imitation learning. Imitation learning may be more reliant on self-other comparison processes (based on mirror neurons) that identify differences as well as similarities between actions. Differential connectivity with the amygdala-orbitofrontal system may also be important. This could have implications for developing "theory of mind," with intentional self-other comparison being relevant to meta-representational abilities, and "automatic" imitation being more relevant to empathy. While it seems clear that autism is associated with impaired development of embodied aspects of cognition, the ways that mirror neurons contribute to these brain-behavior links are likely to be complex. PMID:19360654

  2. An Integrated Solid-State LED Luminaire for General Lighting

    SciTech Connect

    Kevin Dowling; Fritz Morgan Ihor Lys; Mike Datta; Bernd Keller; Thomas Yuan

    2009-03-31

    A strong systems approach to designing and building practical LED-based replacement lamps is lacking. The general method of taking high-performance LEDs and marrying them to standard printed circuit boards, drivers and a heat sink has fallen short of the promise of LED lighting. In this program, a top-down assessment of requirements and a bottom-up reinvention of LED sources, electronics, optics and mechanics have resulted in the highest performance lamp possible. The team, comprised of Color Kinetics, the leaders in LED lighting and Cree, the leaders in LED devices took an approach to reinvent the package, the driver and the overall form and aesthetic of a replacement source. The challenge was to create a new benchmark in LED lighting - the resultant lamp, a PAR38 equivalent, met the light output, color, color quality and efficacy marks set out in the program as well as being dimmable, which is important for market acceptance. The approach combined the use of multiple source die, a chip-on-board approach, a very efficient driver topology, the use of both direct emission and phosphor conversion, and a unique faceted optic to avoid the losses, artifacts and hotspots of lensed approaches. The integral heat sink provided a mechanical base and airflow using a chimney-effect for use in a wide variety of locations and orientations. These research results led to a much better understanding of the system effects of component level technologies. It was clear that best-of-breed sub-system results do not necessarily result in the best end result for the complete system. In doing this work, we did not neglect the practical aspects of these systems. These were not rarified results and commercially impractical but lent themselves to eventual commercial products in the marketplace. The end result - a high performance replacement lamp - will save significant energy while providing a high-quality light source.

  3. Beliefs and attitudes of male and female adolescents and the risk of smoking behavior

    PubMed Central

    Kasim, K; Al-Zalabani, A; Abd El-Moneim, ES; Amer, S

    2016-01-01

    Background: Adolescent smoking relates to numerous risk factors, of which beliefs and attitudes toward smoking may play a role. The study aimed to investigate the association between beliefs and attitudes and the risk of adolescent smoking. Materials and Methods: In a school-based cross-sectional study, 3,400 students were recruited from 34 intermediate and secondary schools in Madinah City, Al Madinah Region, Saudi Arabia. Data about sociodemographics, smoking-related factors, and beliefs and attitudes toward smoking were collected using a valid and reliable self-administered questionnaire. Prevalence of smoking was estimated and the studied beliefs and attitudes were compared by smoking status and sex using appropriate statistical analyses including multivariate logistic regression. Results: Of the 3,322 respondents, 33.02% (38.9% males and 26.4% females) were current smokers. Beliefs and attitudes toward smoking significantly differed between smokers and nonsmokers in the studied male and female students. The adjusted risk of smoking was significantly increased among female adolescents who believed that male smokers were more attractive [odds ratio (OR) = 2.2; 95% confidence interval (CI) = 1.6-2.9] and among male smokers who believed that female smokers are more attractive (OR = 1.7; 95% CI = 1.2-2.2). The risk was also increased among all adolescents who believed that smoking lent comfort in social gatherings. Belief that smoking is harmful, however, was negatively associated with the risk of smoking, particularly among females (OR = 0.55; 95% CI = 0.35-0.91). Conclusions: The study revealed a considerable high prevalence of smoking among male and female adolescents. Addressing the beliefs and knowledge about smoking during childhood is crucial in any antismoking program. PMID:27089105

  4. Combined Adjuvant Radiochemotherapy With IMRT/XELOX Improves Outcome With Low Renal Toxicity in Gastric Cancer

    SciTech Connect

    Boda-Heggemann, Judit; Hofheinz, Ralf-Dieter; Weiss, Christel; Mennemeyer, Philipp; Mai, Sabine K.; Hermes, Petra; Wertz, Hansjoerg; Post, Stefan; Massner, Bernd; Hieber, Udo; Hochhaus, Andreas; Wenz, Frederik; Lohr, Frank

    2009-11-15

    Objectives: Adjuvant radiochemotherapy improves survival of patients with advanced gastric cancer. We assessed in two sequential cohorts whether improved radiotherapy technique (IMRT) together with intensified chemotherapy improves outcome vs. conventional three-dimensional conformal radiotherapy (3D-CRT) and standard chemotherapy in these patients while maintaining or reducing renal toxicity. Materials and Methods: Sixty consecutive patients treated for gastric cancer either with 3D-CRT (n = 27) and IMRT (n = 33) were evaluated. More than 70% had undergone D2 resection. Although there was a slight imbalance in R0 status between cohorts, N+ status was balanced. Chemotherapy consisted predominantly of 5-fluorouracil/folinic acid (n = 36) in the earlier cohort and mostly of oxaliplatin/capecitabine (XELOX, n = 24) in the later cohort. Primary end points were overall survival (OS), disease-free survival (DFS), and renal toxicity based on creatinine levels. Results: Median follow-up (FU) of all patients in the 3D-CRT group was 18 months and in the IMRT group 22 months (median FU of surviving patients 67 months in the 3D-CRT group and 25 months in the IMRT group). Overall median survival (and DFS) were 18 (13) months in the 3D-CRT group and both not reached in the IMRT group (p = 0.0492 and 0.0216). Actuarial 2-year survival was 37% and 67% in the 3D-CRT and IMRT groups, respectively. No late renal toxicity >Grade 2 (LENT-SOMA scale) was observed in either cohort. Conclusion: When comparing sequentially treated patient cohorts with similar characteristics, OS and DFS improved with the use of IMRT and intensified chemotherapy without signs of increased renal toxicity.

  5. Development of Advanced Continuum Models that Incorporate Nanomechanical Deformation into Engineering Analysis.

    SciTech Connect

    Zimmerman, Jonathan A.; Jones, Reese E.; Templeton, Jeremy Alan; McDowell, David L.; Mayeur, Jason R.; Tucker, Garritt J.; Bammann, Douglas J.; Gao, Huajian

    2008-09-01

    Materials with characteristic structures at nanoscale sizes exhibit significantly different mechani-cal responses from those predicted by conventional, macroscopic continuum theory. For example,nanocrystalline metals display an inverse Hall-Petch effect whereby the strength of the materialdecreases with decreasing grain size. The origin of this effect is believed to be a change in defor-mation mechanisms from dislocation motion across grains and pileup at grain boundaries at mi-croscopic grain sizes to rotation of grains and deformation within grain boundary interface regionsfor nanostructured materials. These rotational defects are represented by the mathematical conceptof disclinations. The ability to capture these effects within continuum theory, thereby connectingnanoscale materials phenomena and macroscale behavior, has eluded the research community.The goal of our project was to develop a consistent theory to model both the evolution ofdisclinations and their kinetics. Additionally, we sought to develop approaches to extract contin-uum mechanical information from nanoscale structure to verify any developed continuum theorythat includes dislocation and disclination behavior. These approaches yield engineering-scale ex-pressions to quantify elastic and inelastic deformation in all varieties of materials, even those thatpossess highly directional bonding within their molecular structures such as liquid crystals, cova-lent ceramics, polymers and biological materials. This level of accuracy is critical for engineeringdesign and thermo-mechanical analysis is performed in micro- and nanosystems. The researchproposed here innovates on how these nanoscale deformation mechanisms should be incorporatedinto a continuum mechanical formulation, and provides the foundation upon which to develop ameans for predicting the performance of advanced engineering materials.4 AcknowledgmentThe authors acknowledge helpful discussions with Farid F. Abraham, Youping Chen, Terry J

  6. Testing for shared biogeographic history in the lower Central American freshwater fish assemblage using comparative phylogeography: concerted, independent, or multiple evolutionary responses?

    PubMed Central

    Bagley, Justin C; Johnson, Jerald B

    2014-01-01

    A central goal of comparative phylogeography is determining whether codistributed species experienced (1) concerted evolutionary responses to past geological and climatic events, indicated by congruent spatial and temporal patterns (“concerted-response hypothesis”); (2) independent responses, indicated by spatial incongruence (“independent-response hypothesis”); or (3) multiple responses (“multiple-response hypothesis”), indicated by spatial congruence but temporal incongruence (“pseudocongruence”) or spatial and temporal incongruence (“pseudoincongruence”). We tested these competing hypotheses using DNA sequence data from three livebearing fish species codistributed in the Nicaraguan depression of Central America (Alfaro cultratus, Poecilia gillii, and Xenophallus umbratilis) that we predicted might display congruent responses due to co-occurrence in identical freshwater drainages. Spatial analyses recovered different subdivisions of genetic structure for each species, despite shared finer-scale breaks in northwestern Costa Rica (also supported by phylogenetic results). Isolation-with-migration models estimated incongruent timelines of among-region divergences, with A. cultratus and Xenophallus populations diverging over Miocene–mid-Pleistocene while P. gillii populations diverged over mid-late Pleistocene. Approximate Bayesian computation also lent substantial support to multiple discrete divergences over a model of simultaneous divergence across shared spatial breaks (e.g., Bayes factor [B10] = 4.303 for Ψ [no. of divergences] > 1 vs. Ψ = 1). Thus, the data support phylogeographic pseudoincongruence consistent with the multiple-response hypothesis. Model comparisons also indicated incongruence in historical demography, for example, support for intraspecific late Pleistocene population growth was unique to P. gillii, despite evidence for finer-scale population expansions in the other taxa. Empirical tests for phylogeographic congruence

  7. α-Synuclein inclusions in the skin of Parkinson's disease and parkinsonism

    PubMed Central

    Rodríguez-Leyva, Ildefonso; Calderón-Garcidueñas, Ana Laura; Jiménez-Capdeville, María E; Rentería-Palomo, Ana Arely; Hernandez-Rodriguez, Héctor Gerardo; Valdés-Rodríguez, Rodrigo; Fuentes-Ahumada, Cornelia; Torres-Álvarez, Bertha; Sepúlveda-Saavedra, Julio; Soto-Domínguez, Adolfo; Santoyo, Martha E; Rodriguez-Moreno, José Ildefonso; Castanedo-Cázares, Juan Pablo

    2014-01-01

    Objective The presence in the brain of α-synuclein containing Lewy neurites, or bodies, is the histological hallmark of Parkinson's disease (PD). The discovery of α-synuclein aggregates in nerve endings of the heart, digestive tract, and skin has lent support to the concept of PD as a systemic disease. Our goals were, first, to demonstrate the presence of α-synuclein inclusions in the skin and, second, to detect quantitative differences between patients with PD and atypical parkinsonism (AP). Methods Skin biopsies were taken from 67 patients and 20 controls. The biopsies underwent immunohistochemistry (IHC) and immunofluorescence (IF) testing for α-synuclein, whereupon its presence was quantified as the percentage of positive cells. Patients were divided into those with PD and those with AP. AP patients included AP with neurodegenerative disease (proteinopathies) and secondary AP. Results Sixty-seven patients (34 with PD) and 20 controls were recruited. In the PD group, α-synuclein was detected in 58% of the cells in the spinous cell layer (SCL), 62% in the pilosebaceous unit (PSU), and 58% in the eccrine glands (EG). The AP-proteinopathies group showed 7%, 7%, and 0% expression of α-synuclein, respectively. No expression was found in the skin of the control group. Conclusions The expression of α-synuclein in the skin was relatively high in the PD group, scarce in AP, and null for the individuals in the control group. While these findings require further confirmation, this minimally invasive technique may aid in the improvement of the accuracy of PD diagnoses. PMID:25356418

  8. Application de la diffraction des rayons X in situ à haute température pour l'identification d'une nouvelle phase lors de l'oxydation à 900circC de l'acier 304

    NASA Astrophysics Data System (ADS)

    Riffard, F.; Buscail, H.; Caudron, E.; Cueff, R.; Issartel, C.; El Messki, S.; Perrier, S.

    2004-11-01

    Une nouvelle interprétation du comportement atypique couramment appelé "breakaway" observé lors de l'oxydation à haute température d'alliages chromino-formeurs est proposée grâce à l'utilisation de la diffraction des rayons X in situ à haute température. L'acier chromino-formeur AISI 304 doit établir une couche d'oxyde superficielle généralement dense et majoritairement, constituée de chromine, dont la vitesse de croissance est lente, afin d'assurer sa protection contre la corrosion à haute température. Cette faible vitesse de croissance de la couche d'oxyde est effectivement observée à 1000circC. Elle serait favorisée par l'établissement d'une couche de chromine induite par la présence d'une sous-couche continue de silice à l'interface interne. Cette dernière limiterait la diffusion du fer. Le phénomène du "breakaway" est observé à la température de 900circC après 40 heures d'oxydation. Ce phénomène serait lié à la croissance initiale d'oxydes contenant du fer. L'oxyde Fe{7}SiO{10, }a été identifié{ }pour la première fois grâce à la technique de diffraction des rayons X in situ à haute température. Cet oxyde semble piéger le silicium dans la couche d'oxyde, empêchant son accumulation à l'interface interne et la formation d'une couche continue de silice.

  9. Late Side Effects and Quality of Life After Radiotherapy for Rectal Cancer

    SciTech Connect

    Bruheim, Kjersti; Guren, Marianne G.; Skovlund, Eva; Hjermstad, Marianne J.; Dahl, Olav; Frykholm, Gunilla; Carlsen, Erik; Tveit, Kjell Magne

    2010-03-15

    Purpose: There is little knowledge on long-term morbidity after radiotherapy (50 Gy) and total mesorectal excision for rectal cancer. Therefore, late effects on bowel, anorectal, and urinary function, and health-related quality of life (QoL), were studied in a national cohort (n = 535). Methods and Materials: All Norwegian patients who received pre- or postoperative (chemo-)radiotherapy for rectal cancer from 1993 to 2003 were identified. Patients treated with surgery alone served as controls. Patients were without recurrence or metastases. Bowel and urinary function was scored with the LENT SOMA scale and the St. Marks Score for fecal incontinence and QoL with the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30). Results: Median time since surgery was 4.8 years. Radiation-treated (RT+) patients (n = 199) had increased bowel frequency compared with non-radiation-treated (RT-) patients (n = 336); 19% vs. 6% had more than eight daily bowel movements (p < 0.001). In patients without stoma, a higher proportion of RT+ (n = 69) compared with RT- patients (n = 240), were incontinent for liquid stools (49% vs. 15%, p < 0.001), needed a sanitary pad (52% vs. 13%, p < 0.001), and lacked the ability to defer defecation (44% vs. 16%, p < 0.001). Daily urinary incontinence occurred more frequently after radiotherapy (9% vs. 2%, p = 0.001). Radiation-treated patients had worse social function than RT- patients, and patients with fecal or urinary incontinence had impaired scores for global quality of life and social function (p < 0.001). Conclusions: Radiotherapy for rectal cancer is associated with considerable long-term effects on anorectal function, especially in terms of bowel frequency and fecal incontinence. RT+ patients have worse social function, and fecal incontinence has a negative impact on QoL.

  10. Entitativity and intergroup bias: How belonging to a cohesive group allows people to express their prejudices.

    PubMed

    Effron, Daniel A; Knowles, Eric D

    2015-02-01

    We propose that people treat prejudice as more legitimate when it seems rationalistic-that is, linked to a group's pursuit of collective interests. Groups that appear to be coherent and unified wholes (entitative groups) are most likely to have such interests. We thus predicted that belonging to an entitative group licenses people to express prejudice against outgroups. Support for this idea came from 3 correlational studies and 5 experiments examining racial, national, and religious prejudice. The first 4 studies found that prejudice and discrimination seemed more socially acceptable to third parties when committed by members of highly entitative groups, because people could more easily explain entitative groups' biases as a defense of collective interests. Moreover, ingroup entitativity only lent legitimacy to outgroup prejudice when an interests-based explanation was plausible-namely, when the outgroup could possibly threaten the ingroup's interests. The last 4 studies found that people were more willing to express private prejudices when they perceived themselves as belonging to an entitative group. Participants' perceptions of their own race's entitativity were associated with a greater tendency to give explicit voice to their implicit prejudice against other races. Furthermore, experimentally raising participants' perceptions of ingroup entitativity increased explicit expressions of outgroup prejudice, particularly among people most likely to privately harbor such prejudices (i.e., highly identified group members). Together, these findings demonstrate that entitativity can lend a veneer of legitimacy to prejudice and disinhibit its expression. We discuss implications for intergroup relations and shifting national demographics. (PsycINFO Database Record (c) 2015 APA, all rights reserved).

  11. Self-other relations in social development and autism: multiple roles for mirror neurons and other brain bases.

    PubMed

    Williams, Justin H G

    2008-04-01

    Mirror neuron system dysfunction may underlie a self-other matching impairment, which has previously been suggested to account for autism. Embodied Cognition Theory, which proposes that action provides a foundation for cognition has lent further credence to these ideas. The hypotheses of a self-other matching deficit and impaired mirror neuron function in autism have now been well supported by studies employing a range of methodologies. However, underlying mechanisms require further exploration to explain how mirror neurons may be involved in attentional and mentalizing processes. Impairments in self-other matching and mirror neuron function are not necessarily inextricably linked and it seems possible that different sub-populations of mirror neurons, located in several regions, contribute differentially to social cognitive functions. It is hypothesized that mirror neuron coding for action-direction may be required for developing attentional sensitivity to self-directed actions, and consequently for person-oriented, stimulus-driven attention. Mirror neuron networks may vary for different types of social learning such as "automatic" imitation and imitation learning. Imitation learning may be more reliant on self-other comparison processes (based on mirror neurons) that identify differences as well as similarities between actions. Differential connectivity with the amygdala-orbitofrontal system may also be important. This could have implications for developing "theory of mind," with intentional self-other comparison being relevant to meta-representational abilities, and "automatic" imitation being more relevant to empathy. While it seems clear that autism is associated with impaired development of embodied aspects of cognition, the ways that mirror neurons contribute to these brain-behavior links are likely to be complex.

  12. Putting leadership back into strategy.

    PubMed

    Montgomery, Cynthia A

    2008-01-01

    In recent decades an infusion of economics has lent the study of strategy much needed theory and empirical evidence. Strategy consultants, armed with frameworks and techniques, have stepped forward to help managers analyze their industries and position their companies for strategic advantage. Strategy has come to be seen as an analytical problem to be solved. But, says Montgomery, the Timken Professor of Business Administration at Harvard Business School, the benefits of this rigorous approach have attendant costs: Strategy has become a competitive game plan, separate from the company's larger sense of purpose. The CEO's unique role as arbiter and steward of strategy has been eclipsed. And an overemphasis on sustainable competitive advantage has obscured the importance of making strategy a dynamic tool for guiding the company's development over time. For any company, intelligent guidance requires a clear sense of purpose, of what makes the organization truly distinctive. Purpose, Montgomery says, serves as both a constraint on activity and a guide to behavior. Creativity and insight are key to forging a compelling organizational purpose; analysis alone will never suffice. As the CEO--properly a company's chief strategist--translates purpose into practice, he or she must remain open to the possibility that the purpose itself may need to change. Lou Gerstner did this in the 1990s, when he decided that IBM would evolve to focus on applying technology rather than on inventing it. So did Steve Jobs, when he rescued Apple from a poorly performing strategy and expanded the company into attractive new businesses. Watching over strategy day in and day out is the CEO's greatest opportunity to shape the firm as well as outwit the competition. PMID:18271318

  13. Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conserving surgery enhances late toxicities: Long-term results of the ARCOSEIN multicenter randomized study

    SciTech Connect

    Toledano, Alain . E-mail: alain.toledano@gmail.com; Garaud, Pascal; Serin, Daniel; Fourquet, Alain; Bosset, Jean-Francois; Breteau, Noel; Body, Gilles; Azria, David; Le Floch, Olivier; Calais, Gilles

    2006-06-01

    Purpose: In 1996, a multicenter randomized study was initiated that compared sequential vs. concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) after breast-conserving surgery (ARCOSEIN study). After a median follow-up of 6.7 years (range, 4.3-9 years), we decided to prospectively evaluate the late effects of these 2 strategies. Methods and Materials: A total of 297 patients from the 5 larger participating institutions were asked to report for a follow-up examination. Seventy-two percent (214 patients) were eligible for evaluation of late toxicity. After breast-conserving surgery, patients were treated either with sequential treatment with CT first followed by RT (Arm A) or CT administered concurrently with RT (Arm B). In all patients, CT regimen consisted of mitoxantrone (12 mg/m{sup 2}), 5-FU (500 mg/m{sup 2}), and cyclophosphamide (500 mg/m{sup 2}), 6 cycles (Day 1 to Day 21). Conventional RT was delivered to the whole breast by administration of a 2 Gy per fraction protocol to a total dose of 50 Gy ({+-} boost to the primary tumor bed). The assessment of toxicity was blinded to treatment and was graded by the radiation oncologist, according to the LENT/SOMA scale. Skin pigmentation was also evaluated according to a personal 5-points scoring system (excellent, good, moderate, poor, very poor). Results: Among the 214 evaluable patients, 107 were treated in each arm. The 2 populations were homogeneous for patient, tumor, and treatment characteristics. Subcutaneous fibrosis (SF), telangectasia (T), skin pigmentation (SP), and breast atrophy (BA) were significantly increased in Arm B. No statistical difference was observed between the 2 arms of the study concerning Grade 2 or higher pain, breast edema, or lymphedema. No deaths were caused by late toxicity. Conclusion: After breast-conserving surgery, the concurrent use of CT with RT is significantly associated with an increase incidence of Grade 2 or greater late side effects.

  14. Hypofractionated Versus Conventionally Fractionated Radiotherapy for Prostate Carcinoma: Final Results of Phase III Randomized Trial

    SciTech Connect

    Yeoh, Eric E.; Botten, Rochelle J.; Butters, Julie; Di Matteo, Addolorata C.; Holloway, Richard H.; Fowler, Jack

    2011-12-01

    Purpose: To evaluate the long-term efficacy and toxicity of a hypofractionated (55 Gy in 20 fractions within 4 weeks) vs. a conventionally fractionated (64 Gy in 32 fractions within 6.5 weeks) dose schedule for radiotherapy (RT) for localized carcinoma of the prostate. Methods and Materials: A total of 217 patients were randomized to either the hypofractionated (n = 108) or the conventional (n = 109) dose schedule. Most patients (n = 156) underwent RT planning and RT using a two-dimensional computed tomography method. Efficacy using the clinical, radiologic, and prostate-specific antigen data in each patient was evaluated before RT and at predetermined intervals after RT until death. Gastrointestinal and genitourinary toxicity using the modified Late Effect in Normal Tissue - Subjective Objective Management Analytic (LENT-SOMA) scales was also evaluated before and at intervals after RT to 60 months. Results: The whole group has now been followed for a median of 90 months (range, 3-138). Of the 217 patients, 85 developed biochemical relapse (nadir prostate-specific antigen level + 2 {mu}g/L), 36 in the hypofractionated and 49 in the conventional group. The biochemical relapse-free, but not overall, survival at 90 months was significantly better with the hypofractionated (53%) than with the conventional (34%) schedule. Gastrointestinal and genitourinary toxicity persisted 60 months after RT and did not differ between the two dose schedules. Multivariate analyses revealed that the conventional schedule was of independent prognostic significance, not only for biochemical failure, but also for an increased risk of worse genitourinary symptoms at 4 years. Conclusions: A therapeutic advantage of the hypofractionated compared with the conventional dose schedule for RT of prostate cancer was evident at 90 months in the present study.

  15. Late Patient-Reported Toxicity After Preoperative Radiotherapy or Chemoradiotherapy in Nonresectable Rectal Cancer: Results From a Randomized Phase III Study

    SciTech Connect

    Braendengen, Morten; Tveit, Kjell Magne; Bruheim, Kjersti; Cvancarova, Milada; Berglund, Ake; Glimelius, Bengt

    2011-11-15

    Purpose: Preoperative chemoradiotherapy (CRT) is superior to radiotherapy (RT) in locally advanced rectal cancer, but the survival gain is limited. Late toxicity is, therefore, important. The aim was to compare late bowel, urinary, and sexual functions after CRT or RT. Methods and Materials: Patients (N = 207) with nonresectable rectal cancer were randomized to preoperative CRT or RT (2 Gy Multiplication-Sign 25 {+-} 5-fluorouracil/leucovorin). Extended surgery was often required. Self-reported late toxicity was scored according to the LENT SOMA criteria in a structured telephone interview and with questionnaires European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30), International Index of Erectile Function (IIEF), and sexual function -vaginal changes questionnaire (SVQ). Results: Of the 105 patients alive in Norway and Sweden after 4 to 12 years of follow-up, 78 (74%) responded. More patients in the CRT group had received a stoma (73% vs. 52%, p = 0.09). Most patients without a stoma (7 of 12 in CRT group and 9 of 16 in RT group) had incontinence for liquid stools or gas. No stoma and good anal function were seen in 5 patients (11%) in the CRT group and in 11 (30%) in the RT group (p = 0.046). Of 44 patients in the CRT group, 12 (28%) had had bowel obstruction compared with 5 of 33 (15%) in the RT group (p = 0.27). One-quarter of the patients reported urinary incontinence. The majority of men had severe erectile dysfunction. Few women reported sexual activity during the previous month. However, the majority did not have concerns about their sex life. Conclusions: Fecal incontinence and erectile dysfunction are frequent after combined treatment for locally advanced rectal cancer. There was a clear tendency for the problems to be more common after CRT than after RT.

  16. The Global S_1 Tide in Earth's Nutation

    NASA Astrophysics Data System (ADS)

    Schindelegger, Michael; Einšpigel, David; Salstein, David; Böhm, Johannes

    2016-05-01

    Diurnal S_1 tidal oscillations in the coupled atmosphere-ocean system induce small perturbations of Earth's prograde annual nutation, but matching geophysical model estimates of this Sun-synchronous rotation signal with the observed effect in geodetic Very Long Baseline Interferometry (VLBI) data has thus far been elusive. The present study assesses the problem from a geophysical model perspective, using four modern-day atmospheric assimilation systems and a consistently forced barotropic ocean model that dissipates its energy excess in the global abyssal ocean through a parameterized tidal conversion scheme. The use of contemporary meteorological data does, however, not guarantee accurate nutation estimates per se; two of the probed datasets produce atmosphere-ocean-driven S_1 terms that deviate by more than 30 μ as (microarcseconds) from the VLBI-observed harmonic of -16.2+i113.4 μ as. Partial deficiencies of these models in the diurnal band are also borne out by a validation of the air pressure tide against barometric in situ estimates as well as comparisons of simulated sea surface elevations with a global network of S_1 tide gauge determinations. Credence is lent to the global S_1 tide derived from the Modern-Era Retrospective Analysis for Research and Applications (MERRA) and the operational model of the European Centre for Medium-Range Weather Forecasts (ECMWF). When averaged over a temporal range of 2004 to 2013, their nutation contributions are estimated to be -8.0+i106.0 μ as (MERRA) and -9.4+i121.8 μ as (ECMWF operational), thus being virtually equivalent with the VLBI estimate. This remarkably close agreement will likely aid forthcoming nutation theories in their unambiguous a priori account of Earth's prograde annual celestial motion.

  17. Geothermal Exploration in Hot Springs, Montana

    SciTech Connect

    Toby McIntosh, Jackola Engineering

    2012-09-26

    The project involves drilling deeper in the Camp Aqua well dri lled in June 1982 as part of an effort to develop an ethanol plant. The purpose of the current drill ing effort is to determine if water at or above 165°F exists for the use in low temperature resource power generation. Previous geothermal resource study efforts in and around Hot Springs , MT and the Camp Aqua area (NE of Hot Springs) have been conducted through the years. A confined gravel aquifer exists in deep alluvium overlain by approximately 250 of si lt and c lay deposits from Glacial Lake Missoula. This gravel aquifer overlies a deeper bedrock aquifer. In the Camp Aqua area several wel l s exist in the gravel aquifer which receives hot water f rom bedrock fractures beneath the area. Prior to this exploration, one known well in the Camp Aqua area penetrated into the bedrock without success in intersecting fractures transporting hot geothermal water. The exploration associated with this project adds to the physical knowledge database of the Camp Aqua area. The dri l l ing effort provides additional subsurface information that can be used to gain a better understanding of the bedrock formation that i s leaking hot geothermal water into an otherwise cold water aquifer. The exi s t ing well used for the explorat ion is located within the center of the hottest water within the gravel aquifer. This lent i t sel f as a logical and economical location to continue the exploration within the existing well. Faced with budget constraints due to unanticipated costs, changing dril l ing techniques stretched the limited project resources to maximize the overa l l well depth which f e l l short of original project goals. The project goal of finding 165°F or hotter water was not achieved; however the project provides additional information and understanding of the Camp Aqua area that could prove valuable in future exploration efforts

  18. Radial Internal Material Handling System (RIMS) for Circular Habitat Volumes

    NASA Technical Reports Server (NTRS)

    Howe, Alan S.; Haselschwardt, Sally; Bogatko, Alex; Humphrey, Brian; Patel, Amit

    2013-01-01

    On planetary surfaces, pressurized human habitable volumes will require a means to carry equipment around within the volume of the habitat, regardless of the partial gravity (Earth, Moon, Mars, etc.). On the NASA Habitat Demonstration Unit (HDU), a vertical cylindrical volume, it was determined that a variety of heavy items would need to be carried back and forth from deployed locations to the General Maintenance Work Station (GMWS) when in need of repair, and other equipment may need to be carried inside for repairs, such as rover parts and other external equipment. The vertical cylindrical volume of the HDU lent itself to a circular overhead track and hoist system that allows lifting of heavy objects from anywhere in the habitat to any other point in the habitat interior. In addition, the system is able to hand-off lifted items to other material handling systems through the side hatches, such as through an airlock. The overhead system consists of two concentric circle tracks that have a movable beam between them. The beam has a hoist carriage that can move back and forth on the beam. Therefore, the entire system acts like a bridge crane curved around to meet itself in a circle. The novelty of the system is in its configuration, and how it interfaces with the volume of the HDU habitat. Similar to how a bridge crane allows coverage for an entire rectangular volume, the RIMS system covers a circular volume. The RIMS system is the first generation of what may be applied to future planetary surface vertical cylinder habitats on the Moon or on Mars.

  19. Two species of Acuaria Bremser, 1811 (Nematoda: Acuarioidea: Acuariidae) in passerine birds from the Area de Conservacion Guanacaste, Costa Rica.

    PubMed

    Zhang, Luping; Brooks, Daniel R; Causey, Douglas

    2003-10-01

    Two species of Acuaria were collected from passerine birds from the Area de Conservacion Guanacaste, Costa Rica. Acuaria mayori Lent, Freitas and Proenca, 1945, was collected from Myiarchus nuttingi. Specimens from Costa Rica differ from the original description by having a spicule ratio of 1:1.5-1.7 versus 1:1.43-1.47, as well as shorter spicules and female tails. Acuaria wangi n. sp. in Hylophylax naevioides and Gymnopithys leucaspis resembles A. alii, A. crami, A. cyanocitta, A. minuta, A. pattoni, and A. cissae by having cordons extending posteriorly to the anterior portion of the glandular esophagus. The new species differs from A. alii by having 4 pairs of preanal and 6 pairs of postanal papillae rather than 2 pairs of preanal and 7 pairs of postanal papillae, a shorter left spicule, a spicule ratio of 1:1.6-1.8 versus 1:1.1 and in having spicules with blunt rather than pointed distal ends. Acuaria crami and A. minuta differ from A. wangi by having 7 pairs of postanal papillae and spicule ratios of 1:1.6-1.8 versus 1:1.3 in A. crami and 1:1.1 in A. minuta; in addition, A. minuta has spatulate-shaped spicules and a tricupsid-shaped distal end of the right spicule. The new species can be distinguished from A. pattoni by having a longer left spicule and a spicule ratio of 1:1.6-1.8 versus 1:1 and from A. cissae by having a shorter left spicule and a spicule ratio of 1:1.6-1.8 versus 1:2.5-2.7. Acuaria wangi is similar to A. cyanocitta, which has similarly shaped spicules, including a very pointed distal end of the left spicule, but differs in body length, in having shorter spicules, in the arrangement of postanal papillae, and in having smaller eggs.

  20. Acceptance patterns and decision-making for human papillomavirus vaccination among parents in Vietnam: an in-depth qualitative study post-vaccination

    PubMed Central

    2012-01-01

    Background The GAVI Alliance’s decision in late 2011 to invite developing countries to apply for funding for human papillomavirus (HPV) vaccine introduction underscores the importance of understanding levels of HPV vaccine acceptance in developing country settings. In this paper, we present findings from qualitative research on parents’ rationales for vaccinating or not vaccinating their daughters (vaccine acceptance) and their decision-making process in the context of an HPV vaccination demonstration project in Vietnam (2008–2009). Methods We designed a descriptive qualitative study of HPV vaccine acceptability among parents of girls eligible for vaccination in four districts of two provinces in Vietnama. The study was implemented after each of two years of vaccinations was completed. In total, 133 parents participated in 16 focus group discussions and 27 semi-structured interviews. Results Focus group discussions and in-depth interviews with parents of girls vaccinated revealed that they were generally very supportive of immunization for disease prevention and of vaccinating girls against HPV. The involvement of the National Expanded Program of Immunization in the demonstration project lent credibility to the HPV vaccine, contributing to high levels of acceptance. For parents who declined participation, concerns about side effects, the possibility that the vaccine was experimental, and the possible impact of the vaccine on future fertility rose to the surface. In terms of the decision-making process, many parents exhibited ‘active decision-making,’ reaching out to friends, family, and opinion leaders for guidance prior to making their decision. Conclusion Vietnam’s HPV vaccination experience speaks to the importance of close collaboration with the government to make the most of high levels of trust, and to reduce suspicions about new vaccines that may arise in the context of vaccine introduction in developing country settings. PMID:22877158

  1. Metabolic responses to starch in bread containing intact kernels versus milled flour.

    PubMed

    Liljeberg, H; Granfeldt, Y; Björck, I

    1992-08-01

    In the present study, the potential of including intact kernels from different cereals was evaluated as a means of developing bread with 'lente' characteristics. Postprandial glucose and insulin responses to bread products were studied in healthy subjects. In parallel, the in-vitro enzymic starch availability was investigated. Also studied were the contents of in-vitro indigestible starch. Coarse bread (CB) products composed of 80% pre-boiled kernels from wheat, rye, oats or barley and 20% white wheat flour were baked. In the case of barley, two forms for pre-treatments was used, boiling and scalding. A bread with 80% wholemeal barley flour and 20% white wheat flour (WMB) was also included and a white wheat bread (WWB) was used as reference. The glycaemic and insulinaemic indexes (GI and II, respectively) were calculated from the 95 and 120 min incremental blood glucose and insulin areas. The GIs were significantly lower with CB from wheat, rye and barley than with WWB. In contrast, the GIs with CB from oats and WMB from barley were similar to that with WWB. The GIs and IIs were generally closely correlated. However, the II with CB from oats was significantly lower than with WWB despite similar GI. The GIs, and in particular IIs, were closely correlated with the hydrolysis rate index (HI) obtained in vitro, and this procedure can be recommended as a tool for ranking of starchy food. It is concluded that the botanical structure is an important determinant of the enzymic availability and hence of the metabolic responses. The in-vitro indigestible starch content was highest in CB from barley (1.2% dry weight basis) and lowest in CB from oats (0.5%).

  2. Neuropeptide S facilitates mice olfactory function through activation of cognate receptor-expressing neurons in the olfactory cortex.

    PubMed

    Shao, Yu-Feng; Zhao, Peng; Dong, Chao-Yu; Li, Jing; Kong, Xiang-Pan; Wang, Hai-Liang; Dai, Li-Rong; Hou, Yi-Ping

    2013-01-01

    Neuropeptide S (NPS) is a newly identified neuromodulator located in the brainstem and regulates various biological functions by selectively activating the NPS receptors (NPSR). High level expression of NPSR mRNA in the olfactory cortex suggests that NPS-NPSR system might be involved in the regulation of olfactory function. The present study was undertaken to investigate the effects of intracerebroventricular (i.c.v.) injection of NPS or co-injection of NPSR antagonist on the olfactory behaviors, food intake, and c-Fos expression in olfactory cortex in mice. In addition, dual-immunofluorescence was employed to identify NPS-induced Fos immunereactive (-ir) neurons that also bear NPSR. NPS (0.1-1 nmol) i.c.v. injection significantly reduced the latency to find the buried food, and increased olfactory differentiation of different odors and the total sniffing time spent in olfactory habituation/dishabituation tasks. NPS facilitated olfactory ability most at the dose of 0.5 nmol, which could be blocked by co-injection of 40 nmol NPSR antagonist [D-Val(5)]NPS. NPS administration dose-dependently inhibited food intake in fasted mice. Ex-vivo c-Fos and NPSR immunohistochemistry in the olfactory cortex revealed that, as compared with vehicle-treated mice, NPS markedly enhanced c-Fos expression in the anterior olfactory nucleus (AON), piriform cortex (Pir), ventral tenia tecta (VTT), the anterior cortical amygdaloid nucleus (ACo) and lateral entorhinal cortex (LEnt). The percentage of Fos-ir neurons that also express NPSR were 88.5% and 98.1% in the AON and Pir, respectively. The present findings demonstrated that NPS, via selective activation of the neurons bearing NPSR in the olfactory cortex, facilitates olfactory function in mice.

  3. [Sex workers: from stigma to political consciousness].

    PubMed

    Lamas, M

    1996-01-01

    This work provides an overview of the different types of female sex workers in Mexico City, and discusses the recent trend toward politicizing of female sex workers. The sex industry, traditionally known as prostitution, encompasses a variety of activities that are economically and socially hierarchical, and that may be clandestine, public, or semiofficial. The penal code in Mexico does not outlaw prostitution as such, but specifies procuring as an infraction, while the police regulations contain a category of offenses against morals and good customs, which is used to control prostitution. The laws have lent themselves to exploitation and mistreatment of prostitutes, who are also systematically exploited by their "representatives." The stigma of prostitution has prevented political organization of sex industry workers. In Mexico, the AIDS epidemic directly affected prostitutes' lives and initiated their political awakening. In some AIDS-control campaigns, prostitution came to be spoken of as a means of earning a living rather than as a sin, vice, or destiny. AIDS control activities also gave some indication of preoccupation with the human rights of prostitutes. Efforts are underway to form a national organization of prostitutes that would seek to improve their working conditions and social status. To the extent that prostitutes reflect on their circumstances and organize to defend their basic rights, including recognition of their work, they redefine the symbolic terms of gender in which female sexuality is repressed and women are dichotomized as good women or prostitutes. Prostitution is a social institution reflecting the hierarchy of gender. Prostitution should be analyzed as a political problem and not just a personal or individual problem. It should also be studied as a problem of social relations, with attention to the demand side as well as the supply.

  4. Are bedtime nutritional strategies effective in preventing nocturnal hypoglycaemia in patients with type 1 diabetes?

    PubMed

    Desjardins, K; Brazeau, A-S; Strychar, I; Rabasa-Lhoret, R

    2014-07-01

    Hypoglycaemia remains the major limiting factor for adequate diabetes control for patients with type 1 diabetes (T1D), especially during the night-time. Although nutritional strategies for nocturnal hypoglycaemia (NH) prevention are regularly suggested in clinical practice, there is no evidence-based recommendation for the usefulness and optimal composition of a bedtime snack. The aim of this narrative review was to analyse the current state of knowledge on nutritional strategies to prevent NH in individuals with T1D. A literature search was conducted, using PubMed and Medline (1946 to 2013); 16 studies were retrieved. Overall, the level of evidence was low. Results indicated that a calibrated bedtime snack based on bedtime blood glucose (BG) level could be effective to reduce NH occurrence for patients treated with human or animal insulin (short-acting combined with lente, ultralente and/or intermediate-acting insulin), but there is no evidence for patients treated with insulin analogues as part of multiple daily injections or insulin pump regimen. Some evidence suggests that including uncooked cornstarch or alanine in the bedtime snack composition could provide some benefits for the prevention of NH. Individualized recommendations of a bedtime snack intake for patients or situations at high risk for NH (long standing diabetes, hypoglycaemia unawareness, prior physical activity, alcohol consumption, bedtime BG close to hypoglycaemia threshold) appear as a prudent recommendation. On the basis of the available evidence, a bedtime snack cannot be recommended systematically but it might be useful if prescribed in an individualized fashion; further research is needed to evaluate these strategies. PMID:24320159

  5. Carbon Dioxide Separation with Supported Ionic Liquid Membranes

    SciTech Connect

    Luebke, D.R.; Ilconich, J.B.; Myers, C.R.; Pennline, H.W.

    2007-04-01

    Supported liquid membranes are a class of materials that allow the researcher to utilize the wealth of knowledge available on liquid properties as a direct guide in the development of a capture technology. These membranes also have the advantage of liquid phase diffusivities higher than those observed in polymeric membranes which grant proportionally greater permeabilities. The primary shortcoming of the supported liquid membranes demonstrated in past research has been the lack of stability caused by volatilization of the transport liquid. Ionic liquids, which possess high carbon dioxide solubility relative to light gases such as hydrogen, are an excellent candidate for this type of membrane since they have negligible vapor pressure and are not susceptible to evaporation. A study has been conducted evaluating the use of several ionic liquids, including 1-hexyl-3-methyl-imidazolium bis(trifuoromethylsulfonyl)imide, 1-butyl-3-methyl-imidazolium nitrate, and 1-ethyl-3-methyl-imidazolium sulfate in supported ionic liquid membranes for the capture of carbon dioxide from streams containing hydrogen. In a joint project, researchers at the University of Notre Dame lent expertise in ionic liquid synthesis and characterization, and researchers at the National Energy Technology Laboratory incorporated candidate ionic liquids into supports and evaluated the resulting materials for membrane performance. Initial results have been very promising with carbon dioxide permeabilities as high as 950 barrers and significant improvements in carbon dioxide/hydrogen selectivity over conventional polymers at 37C and at elevated temperatures. Results include a comparison of the performance of several ionic liquids and a number of supports as well as a discussion of innovative fabrication techniques currently under development.

  6. Costing the scaling-up of human resources for health: lessons from Mozambique and Guinea Bissau

    PubMed Central

    2010-01-01

    Introduction In the context of the current human resources for health (HRH) crisis, the need for comprehensive Human Resources Development Plans (HRDP) is acute, especially in resource-scarce sub-Saharan African countries. However, the financial implications of such plans rarely receive due consideration, despite the availability of much advice and examples in the literature on how to conduct HRDP costing. Global initiatives have also been launched recently to standardise costing methodologies and respective tools. Methods This paper reports on two separate experiences of HRDP costing in Mozambique and Guinea Bissau, with the objective to provide an insight into the practice of costing exercises in information-poor settings, as well as to contribute to the existing debate on HRH costing methodologies. The study adopts a case-study approach to analyse the methodologies developed in the two countries, their contexts, policy processes and actors involved. Results From the analysis of the two cases, it emerged that the costing exercises represented an important driver of the HRDP elaboration, which lent credibility to the process, and provided a financial framework within which HRH policies could be discussed. In both cases, bottom-up and country-specific methods were designed to overcome the countries' lack of cost and financing data, as well as to interpret their financial systems. Such an approach also allowed the costing exercises to feed directly into the national planning and budgeting process. Conclusions The authors conclude that bottom-up and country-specific costing methodologies have the potential to serve adequately the multi-faceted purpose of the exercise. It is recognised that standardised tools and methodologies may help reduce local governments' dependency on foreign expertise to conduct the HRDP costing and facilitate regional and international comparisons. However, adopting pre-defined and insufficiently flexible tools may undermine the credibility

  7. Impingement and Dislocation in Total HIP Arthroplasty: Mechanisms and Consequences

    PubMed Central

    Brown, Thomas D; Elkins, Jacob M; Pedersen, Douglas R; Callaghan, John J

    2014-01-01

    In contemporary total hip arthroplasty, instability has been a complication in approximately 2% to 5% of primary surgeries and 5% to 10% of revisions. Due to the reduction in the incidence of wear-induced osteolysis that has been achieved over the last decade, instability now stands as the single most common reason for revision surgery. Moreover, even without frank dislocation, impingement and subluxation are implicated in a set of new concerns arising with advanced bearings, associated with the relatively unforgiving nature of many of those designs. Against that backdrop, the biomechanical factors responsible for impingement, subluxation, and dislocation remain under-investigated relative to their burden of morbidity. This manuscript outlines a 15-year program of laboratory and clinical research undertaken to improve the scientific basis for understanding total hip impingement and dislocation. The broad theme has been to systematically evaluate the role of surgical factors, implant design factors, and patient factors in predisposing total hip constructs to impinge, sublux, and/or dislocate. Because this class of adverse biomechanical events had not lent itself well to study with existing approaches, it was necessary to develop (and validate) a series of new research methodologies, relying heavily on advanced finite element formulations. Specific areas of focus have included identifying the biomechanical challenges posed by dislocation-prone patient activities, quantifying design parameter effects and component surgical positioning effects for conventional metal-on-polyethylene implant constructs, and the impingement/dislocation behavior of non-conventional constructs, quantifying the stabilizing role of the hip capsule (and of surgical repairs of capsule defects), and systematically studying impingement and edge loading of hard-on-hard bearings, fracture of ceramic liners, confounding effects of patient obesity, and subluxation-mediated worsening of third body

  8. Adiabatic pipelining: a key to ternary computing with quantum dots.

    PubMed

    Pečar, P; Ramšak, A; Zimic, N; Mraz, M; Lebar Bajec, I

    2008-12-10

    The quantum-dot cellular automaton (QCA), a processing platform based on interacting quantum dots, was introduced by Lent in the mid-1990s. What followed was an exhilarating period with the development of the line, the functionally complete set of logic functions, as well as more complex processing structures, however all in the realm of binary logic. Regardless of these achievements, it has to be acknowledged that the use of binary logic is in computing systems mainly the end result of the technological limitations, which the designers had to cope with in the early days of their design. The first advancement of QCAs to multi-valued (ternary) processing was performed by Lebar Bajec et al, with the argument that processing platforms of the future should not disregard the clear advantages of multi-valued logic. Some of the elementary ternary QCAs, necessary for the construction of more complex processing entities, however, lead to a remarkable increase in size when compared to their binary counterparts. This somewhat negates the advantages gained by entering the ternary computing domain. As it turned out, even the binary QCA had its initial hiccups, which have been solved by the introduction of adiabatic switching and the application of adiabatic pipeline approaches. We present here a study that introduces adiabatic switching into the ternary QCA and employs the adiabatic pipeline approach to successfully solve the issues of elementary ternary QCAs. What is more, the ternary QCAs presented here are sizewise comparable to binary QCAs. This in our view might serve towards their faster adoption.

  9. Identifying Potential Regions of Copy Number Variation for Bipolar Disorder

    PubMed Central

    Chen, Yi-Hsuan; Lu, Ru-Band; Hung, Hung; Kuo, Po-Hsiu

    2014-01-01

    Bipolar disorder is a complex psychiatric disorder with high heritability, but its genetic determinants are still largely unknown. Copy number variation (CNV) is one of the sources to explain part of the heritability. However, it is a challenge to estimate discrete values of the copy numbers using continuous signals calling from a set of markers, and to simultaneously perform association testing between CNVs and phenotypic outcomes. The goal of the present study is to perform a series of data filtering and analysis procedures using a DNA pooling strategy to identify potential CNV regions that are related to bipolar disorder. A total of 200 normal controls and 200 clinically diagnosed bipolar patients were recruited in this study, and were randomly divided into eight control and eight case pools. Genome-wide genotyping was employed using Illumina Human Omni1-Quad array with approximately one million markers for CNV calling. We aimed at setting a series of criteria to filter out the signal noise of marker data and to reduce the chance of false-positive findings for CNV regions. We first defined CNV regions for each pool. Potential CNV regions were reported based on the different patterns of CNV status between cases and controls. Genes that were mapped into the potential CNV regions were examined with association testing, Gene Ontology enrichment analysis, and checked with existing literature for their associations with bipolar disorder. We reported several CNV regions that are related to bipolar disorder. Two CNV regions on chromosome 11 and 22 showed significant signal differences between cases and controls (p < 0.05). Another five CNV regions on chromosome 6, 9, and 19 were overlapped with results in previous CNV studies. Experimental validation of two CNV regions lent some support to our reported findings. Further experimental and replication studies could be designed for these selected regions.

  10. Origin of the Words Denoting Some of the Most Ancient Old World Pulse Crops and Their Diversity in Modern European Languages

    PubMed Central

    Mikić, Aleksandar

    2012-01-01

    This preliminary research was aimed at finding the roots in various Eurasian proto-languages directly related to pulses and giving the words denoting the same in modern European languages. Six Proto-Indo-European roots were indentified, namely arnk(')- (‘a leguminous plant’), *bhabh- (‘field bean’), * (‘a kernel of leguminous plant’, ‘pea’), ghArs- (‘a leguminous plant’), *kek- (‘pea’) and *lent- (‘lentil’). No Proto-Uralic root was attested save hypothetically *kača (‘pea’), while there were two Proto-Altaic roots, *bŭkrV (‘pea’) and * (‘lentil’). The Proto-Caucasianx root * denoted pea, while another one, *hōwł(ā) (‘bean’, ‘lentil’) and the Proto-Basque root *iłha-r (‘pea’, ‘bean’, ‘vetch’) could have a common Proto-Sino-Caucasian ancestor, *hVwłV (‘bean’) within the hypothetic Dené-Caucasian language superfamily. The Modern Maltese preserved the memory of two Proto-Semitic roots, *'adaš- (‘lentil’) and *pūl- (‘field bean’). The presented results prove that the most ancient Eurasian pulse crops were well-known and extensively cultivated by the ancestors of all modern European nations. The attested lexicological continuum witnesses the existence of a millennia-long links between the peoples of Eurasia to their mutual benefit. This research is meant to encourage interdisciplinary concerted actions between plant scientists dealing with crop evolution and biodiversity, archaeobotanists and language historians. PMID:22973458

  11. TU-F-BRF-06: 3D Pancreas MRI Segmentation Using Dictionary Learning and Manifold Clustering

    SciTech Connect

    Gou, S; Rapacchi, S; Hu, P; Sheng, K

    2014-06-15

    Purpose: The recent advent of MRI guided radiotherapy machines has lent an exciting platform for soft tissue target localization during treatment. However, tools to efficiently utilize MRI images for such purpose have not been developed. Specifically, to efficiently quantify the organ motion, we develop an automated segmentation method using dictionary learning and manifold clustering (DLMC). Methods: Fast 3D HASTE and VIBE MR images of 2 healthy volunteers and 3 patients were acquired. A bounding box was defined to include pancreas and surrounding normal organs including the liver, duodenum and stomach. The first slice of the MRI was used for dictionary learning based on mean-shift clustering and K-SVD sparse representation. Subsequent images were iteratively reconstructed until the error is less than a preset threshold. The preliminarily segmentation was subject to the constraints of manifold clustering. The segmentation results were compared with the mean shift merging (MSM), level set (LS) and manual segmentation methods. Results: DLMC resulted in consistently higher accuracy and robustness than comparing methods. Using manual contours as the ground truth, the mean Dices indices for all subjects are 0.54, 0.56 and 0.67 for MSM, LS and DLMC, respectively based on the HASTE image. The mean Dices indices are 0.70, 0.77 and 0.79 for the three methods based on VIBE images. DLMC is clearly more robust on the patients with the diseased pancreas while LS and MSM tend to over-segment the pancreas. DLMC also achieved higher sensitivity (0.80) and specificity (0.99) combining both imaging techniques. LS achieved equivalent sensitivity on VIBE images but was more computationally inefficient. Conclusion: We showed that pancreas and surrounding normal organs can be reliably segmented based on fast MRI using DLMC. This method will facilitate both planning volume definition and imaging guidance during treatment.

  12. Development of a Short-Form Measure of Science and Technology Self-efficacy Using Rasch Analysis

    NASA Astrophysics Data System (ADS)

    Lamb, Richard L.; Vallett, David; Annetta, Leonard

    2014-10-01

    Despite an increased focus on science, technology, engineering, and mathematics (STEM) in U.S. schools, today's students often struggle to maintain adequate performance in these fields compared with students in other countries (Cheek in Thinking constructively about science, technology, and society education. State University of New York, Albany, 1992; Enyedy and Goldberg 2004; Mandinach and Lewis 2006). In addition, despite considerable pressure to promote the placement of students into STEM career fields, U.S. placement is relatively low (Sadler et al. in Sci Educ 96(3):411-427, 2012; Subotnik et al. in Identifying and developing talent in science, technology, engineering, and mathematics (STEM): an agenda for research, policy and practice. International handbook, part XII, pp 1313-1326, 2009). One explanation for the decline of STEM career placement in the U.S. rests with low student affect concerning STEM concepts and related content, especially in terms of self-efficacy. Researchers define self-efficacy as the internal belief that a student can succeed in learning, and that understanding student success lies in students' externalized actions or behaviors (Bandura in Psychol Rev 84(2):191-215, 1977). Evidence suggests that high self-efficacy in STEM can result in student selection of STEM in later educational endeavors, culminating in STEM career selection (Zeldin et al. in J Res Sci Teach 45(9):1036-1058, 2007). However, other factors such as proficiency play a role as well. The lack of appropriate measures of self-efficacy can greatly affect STEM career selection due to inadequate targeting of this affective trait and loss of opportunity for early intervention by educators. Lack of early intervention decreases selection of STEM courses and careers (Valla and Williams in J Women Minor Sci Eng 18(1), 2012; Lent et al. in J Couns Psychol 38(4), 1991). Therefore, this study developed a short-form measure of self-efficacy to help identify students in need of

  13. PREFACE: 9th International Conference on Magnetic and Superconducting Materials (MSM15)

    NASA Astrophysics Data System (ADS)

    Eyyuphan Yakinci, M.; Tanatar, Bilal

    2016-01-01

    The Magnetic and Superconducting Materials (MSM) Conference, which is held biannually in many countries, started in 1999 as a scientific conference on magnetism and superconductivity and their application in materials. Today MSM conferences aim to bring together regional and international research groups and technologists of related companies to discuss new materials, their results and current problems in the areas of superconductivity, magnetism, novel materials and also in the general field of Low Temperature Physics. The main goal of the MSM conference series is to increase collaboration within the region and the third world countries, and with the international community among the scientists from the developed countries. It is only through the sharing of experience with scientists around the world that one could fully benefit from natural and human resources. During the MSM15 conference we have received more than 250 abstracts from 22 different countries, plenary, invited and contributed talks were presented and many scientific subjects were widely discussed. The contributions in this volume have been reviewed by the eminent international scientists and represent some of the invited and contributed talks presented during MSM15 conference. We would like to thank to all of the participants attending the conference and also international scientific committee for their contribution to a high level conference and its overall success. We also would like to thank to our sponsors İnönü University, Gazi University, Çukurova University, Abant İzzet Baysal University and Bülent Ecevit University and more than eight scientific companies during the conference. M. Eyyuphan Yakinci, Bilal Tanatar Editors

  14. Tritium breeding measurements in a lithium blanket module with Pb/Be multipliers at the LOTUS facility

    SciTech Connect

    Azam, S.; Kumar, A.

    1987-01-01

    The lithium blanket module (LBM) was lent for a fixed duration in 1985 to Ecole Polytechnique Federale de Lausanne under an agreement with the Electric Power Research Institute and Princeton Plasma Physics Laboratory. The first tritium breeding measurements in the central rod of the LBM and their analysis have been reported previously. Some time ago, we carried out additional experiments wherein the Li/sub 2/O sample disk, each having a theoretical density of /approx/85% and dimensions of 17.8-mm diam x 0.9-mm thickness, were placed in four removable rods. In addition to the central rod, the other rods were at /approx/6-, 18-, and 39-cm radial distances from the axis of the central one. The sample disks wee kept at every 3 cm inside each of these rods up to a length of 30 cm in the Li/sub 2/O part of the LBM. The choice of the off-axis rods resulted from our interest in investigating the effect of room return on tritium breeding in the LBM. We chose two of the leading neutron multipliers: (a) a 5-cm-thick (/approx/100- x 110-cm) lead slab and (b) a 6-cm-thick (/approx/66- x 66-cm) beryllium slab. The experimental assembly, consisting of the multiplier followed by the LBM, was kept at 10 cm from the generator. A packet of three foils, zirconium, indium, and aluminum, was placed at the center of the flat face of the generator to monitor the source intensity during the 10-h operation for the experiments with each multiplier. The source intensity is deduced to be /approx/1.9 x 10/sup 12/ n/s for both the experiments. 5 refs., 3 figs.

  15. [Preparation and evaluation of pepsin affinity organic polymer capillary monolithic column].

    PubMed

    Chi, Cuijie; Wang, Wei; Ji, Yibing

    2014-08-01

    The protein modified monolithic column in affinity capillary electrochromatography (CEC) has attracted considerable attention over the past decades because of its great enantioseparation ability. A porous polymethacrylate ester-based capillary monolithic column poly (glycidyl methacrylate-co-ethyleneglycol dimethacrylate) (poly (GMA-co-EDMA)) was prepared by in situ co-polymerization. The process was initiated thermally by azobisisobutyronitrile (AIBN). The polymerization mixture contained GMA as the function monomer and EDMA as the crosslinking agent with 1,4-butanediol and 1-propanol as the binary porogen solvent. Under the optimized reaction conditions, including the proportion of monomer and porogens, reaction temperature etc, the column exhibited a uniform structure, sufficient permeability and excel- lent pressure resistance. The separation of alkyl benzenes on the column was mainly based on typical reversed-phase chromatographic retention mechanism. The reproducibility and stability were good with RSDs less than 9. 0%. A pepsin functionalized organic polymer monolith was prepared by covalently bonded pepsin to poly(GMA-co-EDMA) monolith with glutaraldehyde as a spacer based on the activity of epoxide group. The enantioseparation performance of the pepsin affinity monolith for basic enantiomers has been investigated by CEC. Nefopam, amlodipine, citalopram and chlorpheniramine were resolved, and baseline separations of nefopam, amlodipine, citalopram were achieved. The influences of pH, operating voltage, temperature and sample quantity used on the chiral separation were studied. The chiral recognition mechanism of enantiomers on the monolithic column in CEC is discussed. This work developed a new method for the prepataion and application of protein affinity monolith in CEC.

  16. Perturbation of the Monomer-Monomer Interfaces of the Benzoylformate Decarboxylase Tetramer

    SciTech Connect

    Andrews, Forest H.; Rogers, Megan P.; Paul, Lake N.; McLeish, Michael J.

    2014-08-14

    The X-ray structure of benzoylformate decarboxylase (BFDC) from Pseudomonas putida ATCC 12633 shows it to be a tetramer. This was believed to be typical of all thiamin diphosphate-dependent decarboxylases until recently when the structure of KdcA, a branched-chain 2-keto acid decarboxylase from Lactococcus lactis, showed it to be a homodimer. This lent credence to earlier unfolding experiments on pyruvate decarboxylase from Saccharomyces cerevisiae that indicated that it might be active as a dimer. To investigate this possibility in BFDC, we sought to shift the equilibrium toward dimer formation. Point mutations were made in the noncatalytic monomer–monomer interfaces, but these had a minimal effect on both tetramer formation and catalytic activity. Subsequently, the R141E/Y288A/A306F variant was shown by analytical ultracentrifugation to be partially dimeric. It was also found to be catalytically inactive. Further experiments revealed that just two mutations, R141E and A306F, were sufficient to markedly alter the dimer–tetramer equilibrium and to provide an ~450-fold decrease in kcat. Equilibrium denaturation studies suggested that the residual activity was possibly due to the presence of residual tetramer. The structures of the R141E and A306F variants, determined to <1.5 Å resolution, hinted that disruption of the monomer interfaces will be accompanied by movement of a loop containing Leu109 and Leu110. As these residues contribute to the hydrophobicity of the active site and the correct positioning of the substrate, it seems that tetramer formation may well be critical to the catalytic activity of BFDC.

  17. Analysis of Hypothetical Promoter Domains of DKFZp564A1164, NPHS1 and HSPOX1 Genes

    SciTech Connect

    Hammond, S S

    2003-11-29

    For this study, a high throughput method for identifying and testing regulatory elements was examined. In addition, the validity of promoters predicted by FirstEF was tested. It was found that by combining computer based promoter and first exon predictions from FirstEF (Davuluri et al., 2001) with PCR-based cloning to generate luciferase reporter constructs, and by testing reporter activity in cultured mammalian cells plated in a 96 well format one could identify promoter activity in a relatively high throughput manner. The data generated in this study suggest that FirstEF predictions are sometimes incorrect. Therefore, having a strategy for defining which FirstEF predicted promoters to test first may accelerate the process. Initially testing promoters that are at a confirmed transcription start site for a gene, at a possible alternate transcription start site or in a region of conserved sequence would be the best candidates, while promoters predicted in gene desert regions may not be as easy to confirm. The luciferase assay lent itself very well to the high throughput search, however the subcloning did not always go smoothly. The numerous steps that this traditional subcloning method requires were time consuming and increased the opportunities for errors. A faster method that skips many of the traditional subcloning steps, such as the Creator{trademark} system by Clontech is currently being investigated by our lab. The development and testing of substantially larger enhancer/silencer regulatory elements may not be possible at this time using these high throughput methods. These regulatory elements are generally GC rich making them more difficult to PCR and subclone. Additionally, confirming upstream untranslated first exons was not possible within this time scale using the SMART RACE protocol. It will be necessary to further explore the limitations within these procedures in order to confirm these and future regulatory elements. Alterations and modifications to

  18. Implications of a New Global Picture of Land Degradation (Invited)

    NASA Astrophysics Data System (ADS)

    Olsson, L.; Dent, D.

    2009-12-01

    Effective responses to desertification have always been hampered by a lack of a scientific understanding and reliable data on the extent and severity of land degradation. We also argue that the poor scientific understanding of desertification is partly a consequence of the lack of reliable data. Policy development has to a large extent relied upon data from the 1990 GLASOD assessment that was compiled from expert judgements. This is a map of perceptions, not measurements, that doesn't stand scrutiny and lent itself to selective interpretations. Based on the GLASOD assessment, land degradation in arid and semi-arid regions have been emphasised over other regions as hotspots of land degradation. A recent analysis of consistent, remotely-sensed data and climatic observations, using clearly-defined methods, makes allowance for droughts and global warming. It indicates that 24 per cent of land has suffered declining net primary productivity over the last 25 years; this area is home to a quarter of the world's people. When adjusted for climatic variations, the loss of primary productivity is interpreted as land degradation. In contrast to received wisdom, dry lands don't feature strongly. Forests and croplands are most affected by land degradation and protected areas fare no better than anywhere else. Unprecedented land use change is being driven not only by local processes but also by external pressures related to burgeoning population, economic & technology developments and globalisation; and unsustainable land use is causing land degradation. This suggests a need for a policy shift from desertification in dry lands to land degradation globally, and from environmental protection to developmental initiatives. The paper will discuss potential responses to land degradation that are informed by the new insights into the extent and severity of land degradation globally.

  19. Evaluation of Parotid Gland Function following Intensity Modulated Radiation Therapy for Head and Neck Cancer

    PubMed Central

    Lee, Seok Ho; Kim, Tae Hyun; Kim, Joo Young; Park, Sung Yong; Pyo, Hong Ryull; Shin, Kyung Hwan; Kim, Dae Yong; Kim, Joo Young

    2006-01-01

    Purpose This study was undertaken to determine the parotid gland tolerance dose levels following intensity modulated radiation therapy (IMRT) for treating patients who suffered with head and neck cancer. Materials and Methods From February 2003 through June 2004, 34 head and neck patients with 6 months of follow-up were evaluated for xerostomia after being treated by IMRT. Their median age was 59 years (range: 29~78). Xerostomia was assessed using a 4-question xerostomia questionnaire score (XQS) and a test for the salivary flow rates (unstimulated and stimulated: USFR and SSFR, respectively). The patients were also given a validated LENT SOMA scale (LSS) questionnaire. Evaluations were performed before IMRT and at 1, 3 and 6 months after IMRT. Results All 34 patients showed significant changes in the XQS, LSS and Salivary Flow rates (USFR and SSFR) after IMRT. No significant changes in the XQS or LSS were noted in 12 patients who received a total parotid mean dose of ≤3,100 cGy at 1, 3 and 6 months post-IMRT relative to the baseline values. However, for the 22 patients who received >3,100 cGy, significant increases in the XQS and LSS were observed. The USFR and SSFR from the parotid glands in 7 patients who received ≤2,750 cGy were significantly preserved at up to 6 months after IMRT. However, the USFR and SSFR in 27 patients who were treated with >2,750 cGy were significantly lower than the baseline values at all times after IMRT. Conclusion We suggest that the total parotid mean dose should be limited to ≤2,750 cGy to preserve the USFR and SSFR and so improve the subsequent quality of life. PMID:19771265

  20. Geospatial Analysis Using Remote Sensing Images: Case Studies of Zonguldak Test Field

    NASA Astrophysics Data System (ADS)

    Bayık, Çağlar; Topan, Hüseyin; Özendi, Mustafa; Oruç, Murat; Cam, Ali; Abdikan, Saygın

    2016-06-01

    Inclined topographies are one of the most challenging problems for geospatial analysis of air-borne and space-borne imageries. However, flat areas are mostly misleading to exhibit the real performance. For this reason, researchers generally require a study area which includes mountainous topography and various land cover and land use types. Zonguldak and its vicinity is a very suitable test site for performance investigation of remote sensing systems due to the fact that it contains different land use types such as dense forest, river, sea, urban area; different structures such as open pit mining operations, thermal power plant; and its mountainous structure. In this paper, we reviewed more than 120 proceeding papers and journal articles about geospatial analysis that are performed on the test field of Zonguldak and its surroundings. Geospatial analysis performed with imageries include elimination of systematic geometric errors, 2/3D georeferencing accuracy assessment, DEM and DSM generation and validation, ortho-image production, evaluation of information content, image classification, automatic feature extraction and object recognition, pan-sharpening, land use and land cover change analysis and deformation monitoring. In these applications many optical satellite images are used i.e. ASTER, Bilsat-1, IKONOS, IRS-1C, KOMPSAT-1, KVR-1000, Landsat-3-5-7, Orbview-3, QuickBird, Pleiades, SPOT-5, TK-350, RADARSAT-1, WorldView-1-2; as well as radar data i.e. JERS-1, Envisat ASAR, TerraSAR-X, ALOS PALSAR and SRTM. These studies are performed by Departments of Geomatics Engineering at Bülent Ecevit University, at İstanbul Technical University, at Yıldız Technical University, and Institute of Photogrammetry and GeoInformation at Leibniz University Hannover. These studies are financially supported by TÜBİTAK (Turkey), the Universities, ESA, Airbus DS, ERSDAC (Japan) and Jülich Research Centre (Germany).

  1. The effect of animation and concreteness of visuals on immediate recall and long-term comprehension when learning the basic principles and laws of motion

    NASA Astrophysics Data System (ADS)

    Weiss, Renee Elizabeth

    A study was conducted involving 118 undergraduate college students to determine the form of instruction that would result in better understanding and retention of an abstract subject involving motion. It was found, as had been hypothesized, that instruction with animated concrete graphics resulted in statistically significant higher achievement compared with concrete static, abstract static, abstract animated or text only instruction. This finding held true for all three levels of difficulty of the posttest questions. The reasons for this result are proposed to be concrete animation's attention-gaining quality resulting in its inclusion in the selective perception process, reduction in the level of abstraction to aid the short term memory in clearly encoding the information in long-term memory, and because the subject lent itself to imaging, thus dual coding was used beneficially. The animation alone or the concreteness of the illustration alone did not explain the result as shown by the lesson performance of these groups. It was only the combination of animation and concreteness of visual that resulted in higher achievement. There was no relationship between the time spent on task and achievement. There was a weak correlation between the number of times the animation button was used and achievement on the immediate posttest. This did not hold true for the delayed posttest. It was concluded that the difference in achievement was due to the nature of the graphic and not the result of time spent on task. The majority (86%) of the participants found graphics to be useful in their understanding of the subject, and 41% of the text only group commented that graphics would have helped in their understanding. Most of the participants used some form of mental imagery in answering the posttest questions, although a few claimed they did not use mental images.

  2. Effects of Hydrologic Restoration on Flood Resilience and Sediment Dynamics of Urban Creeks in the UK and USA

    NASA Astrophysics Data System (ADS)

    Wright, N.

    2015-12-01

    Hydrologic restoration in urban creeks is increasingly regarded as a more sustainable option than traditional grey infrastructures in many countries including the UK and USA. Hydrologic restoration aims to recreate naturally oriented hydro-morphodynamic processes while adding ecological and amenity value to a river corridor. Nevertheless, the long-term hydraulic performance of river restorations is incompletely understood. The aim of this research was to investigate the long-term effects of river restoration on the water storage, flood attenuation and sediment dynamics of two urban creeks through detailed hydro-morphodynamic modelling. The first case study is based on Johnson Creek located at Portland, Oregon, USA, and the second case based on Ouseburn River in Newcastle upon Tyne, N.E. England. This study focuses on the downstream of the Johnson Creek, where creek is reconnected to a restored East Lents floodplain of 0.28 km2. In order to offset the increased urban runoff in the Ouseburn catchment, a number of attenuation ponds were implemented along the river. In this study, an integrated 1D and 2D flood model (ISIS - TUFLOW) and the recently updated layer-based hydro-morphodynamic model have been used to understand the long-term impacts of these restorations on the flood and sediment dynamics. The event-based simulations (500 year, 100 year, 50 year, 10 year and 5 year), as well as the continuous simulations based on the historical flow datasets were systematically undertaken. Simulation results showed that the flood storage as a result of river restoration attenuate the flood peak by up to 25% at the downstream. Results also indicated that about 30% of the sediments generated from the upstream deposited in the resorted regions. The spatial distribution and amount of short and long-term sediment deposition on the floodplain and pond are demonstrated, and the resulting potential loss of the flood storage capacity are analysed and discussed.

  3. Long-term toxicity of an intraoperative radiotherapy boost using low energy X-rays during breast-conserving surgery

    SciTech Connect

    Kraus-Tiefenbacher, Uta . E-mail: uta.kraus-tiefenbacher@radonk.ma.uni-heidelberg.de; Bauer, Lelia; Scheda, Antonella; Fleckenstein, Katharina; Keller, Anke; Herskind, Carsten; Steil, Volker; Melchert, Frank; Wenz, Frederik

    2006-10-01

    Purpose: Intraoperative radiotherapy (IORT) as a boost for breast cancer delivers a high single dose of radiation to a late-reacting tissue; therefore late toxicity is of particular interest, and long-term follow-up is warranted. To date there are only limited data available on breast cancer patients treated with IORT using low energy X-rays. We analyzed toxicity and cosmesis after IORT as a boost with a minimum follow-up of 18 months. Methods and Materials: A total of 73 patients treated with IORT (20 Gy/50 kV X-rays; INTRABEAM [Carl Zeiss Surgical, Oberkochen, Germany]) to the tumor bed during breast-conserving surgery as a boost followed by whole-breast radiotherapy (WBRT, 46 Gy) underwent a prospective, predefined follow-up (median, 25 months; range 18-44 months), including clinical examination and breast ultrasound at 6-months and mammographies at 1-year intervals. Toxicities were documented using the common toxicity criteria (CTC)/European Organization for Research and Treatment of Cancer and the LENT-SOMA score. Cosmesis was evaluated with a score from 1 to 4. Results: The IORT in combination with WBRT was well tolerated, with no Grade 3 or 4 skin toxicities and no telangiectasias. Fibrosis of the entire breast was observed in 5% of the patients. A circumscribed fibrosis around the tumor bed was palpable in up to 27% with a peak around 18 months after therapy and a decline thereafter. The observed toxicitiy rates were not influenced by age, tumor stage, or systemic therapy. The cosmetic outcome was good to excellent in {>=}90% of cases. Conclusions: After IORT of the breast using low-energy X-rays, no unexpected toxicity rates were observed during long-term-follow-up.

  4. Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer: results from the randomized phase III trial TARGIT A.

    PubMed

    Sperk, Elena; Welzel, Grit; Keller, Anke; Kraus-Tiefenbacher, Uta; Gerhardt, Axel; Sütterlin, Marc; Wenz, Frederik

    2012-08-01

    The randomized phase III trial TARGIT A showed non-inferiority regarding local control after intraoperative radiotherapy (IORT 20 Gy which was followed by whole breast radiotherapy (WBRT) in patients with risk factors only) in comparison to standard WBRT (50-56 Gy) after breast-conserving surgery in selected patients. This is the first analysis of long-term toxicities in the setting of TARGIT. Between 02/2002 and 12/2008, 305 patients were treated within TARGIT A (Arm A: n = 34 IORT, n = 20 IORT + WBRT for risk factors; Arm B WBRT: n = 55) or received IORT as a planned boost (control group: n = 196) at a single center. Toxicity was assessed according to the LENT SOMA scales. No significant differences were seen between Arm A and Arm B regarding fibrosis, breast edema, retraction, ulceration, lymphedema, hyperpigmentation, and pain. Arm A had significantly less telangiectases compared to Arm B (p = 0.049). In the subanalysis (Arm A IORT vs. Arm A IORT + WBRT vs. Arm B), fibrosis had a cumulative rate of 5.9 versus 37.5 versus 18.4 %, respectively (38.2 % IORT boost control group), at 3 years. No telangiectases were seen after IORT alone (0 % Arm A IORT vs. 17.5 % Arm A IORT + WBRT vs. 17.7 % Arm B). The hazard ratio of higher grade toxicity as first event was 0.46 (95 % CI, 0.26-0.83) for Arm A IORT as compared to Arm B (p = 0.010). No recurrences were seen after a median follow-up of 40 months (Arm A) and 42 months (Arm B). With its very low chronic skin toxicity rates and outstanding long-term results regarding toxicity and local control, IORT with 50 kV X-rays is a safe and effective method for treatment of selected breast cancer patients. PMID:22842984

  5. Experiences with Lab-on-a-chip Technology in Support of NASA Supported Research

    NASA Technical Reports Server (NTRS)

    Monaco, Lisa

    2003-01-01

    Under the auspices of the Microgravity Sciences and Application Department at Marshall Space Flight Center, we have custom designed and fabricated a lab-on-a-chip (LOC) device, along with Caliper Technologies, for macromolecular crystal growth. The chip has been designed to deliver specified proportions of up-to five various constituents to one of two growth wells (on-chip) for crystal growth. To date, we have grown crystals of thaumatin, glucose isomerase and appoferitin on the chip. The LOC approach offered many advantages that rendered it highly suitable for space based hardware to perform crystal growth on the International Space Station. The same hardware that was utilized for the crystal growth investigations, has also been used by researchers at Glenn Research Center to investigate aspects of microfluidic phenomenon associated with two-phase flow. Additionally, our LOCAD (Lab-on-a-chip Application Development) team has lent its support to Johnson Space Center s Modular Assay for Solar System Exploration project. At present, the LOCAD team is working on the design and build of a unique lab-on-a-chip breadboard control unit whose function is not commercially available. The breadboard can be used as a test bed for the development of chip size labs for environmental monitoring, crew health monitoring assays, extended flight pharmacological preparations, and many more areas. This unique control unit will be configured for local use and/or remote operation, via the Internet, by other NASA centers. The lab-on-a-chip control unit is being developed with the primary goal of meeting Agency level strategic goals.

  6. Gastrointestinal Dose-Histogram Effects in the Context of Dose-Volume–Constrained Prostate Radiation Therapy: Analysis of Data From the RADAR Prostate Radiation Therapy Trial

    SciTech Connect

    Ebert, Martin A.; Foo, Kerwyn; Haworth, Annette; Gulliford, Sarah L.; Kennedy, Angel; Joseph, David J.; Denham, James W.

    2015-03-01

    Purpose: To use a high-quality multicenter trial dataset to determine dose-volume effects for gastrointestinal (GI) toxicity following radiation therapy for prostate carcinoma. Influential dose-volume histogram regions were to be determined as functions of dose, anatomical location, toxicity, and clinical endpoint. Methods and Materials: Planning datasets for 754 participants in the TROG 03.04 RADAR trial were available, with Late Effects of Normal Tissues (LENT) Subjective, Objective, Management, and Analytic (SOMA) toxicity assessment to a median of 72 months. A rank sum method was used to define dose-volume cut-points as near-continuous functions of dose to 3 GI anatomical regions, together with a comprehensive assessment of significance. Univariate and multivariate ordinal regression was used to assess the importance of cut-points at each dose. Results: Dose ranges providing significant cut-points tended to be consistent with those showing significant univariate regression odds-ratios (representing the probability of a unitary increase in toxicity grade per percent relative volume). Ranges of significant cut-points for rectal bleeding validated previously published results. Separation of the lower GI anatomy into complete anorectum, rectum, and anal canal showed the impact of mid-low doses to the anal canal on urgency and tenesmus, completeness of evacuation and stool frequency, and mid-high doses to the anorectum on bleeding and stool frequency. Derived multivariate models emphasized the importance of the high-dose region of the anorectum and rectum for rectal bleeding and mid- to low-dose regions for diarrhea and urgency and tenesmus, and low-to-mid doses to the anal canal for stool frequency, diarrhea, evacuation, and bleeding. Conclusions: Results confirm anatomical dependence of specific GI toxicities. They provide an atlas summarizing dose-histogram effects and derived constraints as functions of anatomical region, dose, toxicity, and endpoint for

  7. Sequence and Ionomic Analysis of Divergent Strains of Maize Inbred Line B73 with an Altered Growth Phenotype

    PubMed Central

    Gahrtz, Manfred; Bucher, Marcel; Scholz, Uwe; Dresselhaus, Thomas

    2014-01-01

    Maize (Zea mays) is the most widely grown crop species in the world and a classical model organism for plant research. The completion of a high-quality reference genome sequence and the advent of high-throughput sequencing have greatly empowered re-sequencing studies in maize. In this study, plants of maize inbred line B73 descended from two different sets of seed material grown for several generations either in the field or in the greenhouse were found to show a different growth phenotype and ionome under phosphate starvation conditions and moreover a different responsiveness towards mycorrhizal fungi of the species Glomus intraradices (syn: Rhizophagus irregularis). Whole genome re-sequencing of individuals from both sets and comparison to the B73 reference sequence revealed three cryptic introgressions on chromosomes 1, 5 and 10 in the line grown in the greenhouse summing up to a total of 5,257 single-nucleotide polymorphisms (SNPs). Transcriptome sequencing of three individuals from each set lent further support to the location of the introgression intervals and confirmed them to be fixed in all sequenced individuals. Moreover, we identified >120 genes differentially expressed between the two B73 lines. We thus have found a nearly-isogenic line (NIL) of maize inbred line B73 that is characterized by an altered growth phenotype under phosphate starvation conditions and an improved responsiveness towards symbiosis with mycorrhizal fungi. Through next-generation sequencing of the genomes and transcriptomes we were able to delineate exact introgression intervals. Putative de novo mutations appeared approximately uniformly distributed along the ten maize chromosomes mainly representing G:C -> A:T transitions. The plant material described in this study will be a valuable tool both for functional studies of genes differentially expressed in both B73 lines and for research on growth behavior especially in response to symbiosis between maize and mycorrhizal fungi. PMID

  8. Karl Abraham, Sigmund Freud, and the fate of the seduction theory.

    PubMed

    Good, M I

    1995-01-01

    Even after Freud had turned his attention away from the seduction theory of neurosogenesis, his close pupil and colleague, Karl Abraham, initially sought to investigate child sexual trauma further. In two of the very first articles on child sexual molestation, Abraham proposed that sexual abuse was particularly common among neurotic and psychotic patients as a result of a "traumatophilic diathesis," a trauma-related conceptual precursor of the repetition compulsion. In their correspondence, Freud trenchantly criticized many aspects of Abraham's papers on the subject of sexual trauma, in contrast to his public endorsement of Abraham's work in this area. For largely transferential reasons that this paper attempts to elucidate, Abraham did not encourage dialogue regarding persistent questions on the seduction issue, ceased publishing on that topic, and for some time controlled his apparently deep rankle over Freud's criticisms and failure to acknowledge Abraham's contribution to the concept of the repetition compulsion. Despite their close friendship and shared intellectual enthusiasm, Freud's response to Abraham's 1907 papers, as well as Abraham's almost uniformly positive disposition toward Freud, apparently prevented Abraham from further developing his observations and ideas on seduction and also lent background to their later clash. Subsequently, there was virtually no further psychoanalytic investigation of the subject of child sexual abuse until the issue arose briefly with Ferenczi in the early 1930s, and only occasionally after that for the next fifty years. The death of Abraham, and then Ferenczi, shortly after disputes with Freud may be among the factors that had an inhibiting effect on an earlier reconsideration of the seduction theory by others. Abraham's previously unheralded concept of traumatophilia has relevance to current clinical controversy regarding constitution and sexual trauma.

  9. Use of DOE SGP Radars in Support of ASR Modeling Activities

    SciTech Connect

    Rutledge, Steven A.

    2015-12-13

    The objective of this work was to use the DOE Southern Great Plains (SGP) precipitation radars to investigate physical characteristics of clouds and precipitation, and use this knowledge in support of DOE ASR modeling efforts. The goal was to develop an integrated data set based on the SGP instrumentation to yield statistically robust fields to aid in the task of verifying simulated cloud dynamical and microphysical fields. For this effort we relied heavily on the ARM scanning precipitation radars, X-SAPR’s and C-SAPR, and also incorporating data from wind profilers, surface disdrometers and the nearby WSR-88D radar, KVNX. Initially we lent our expertise to quality controlling the data from the newly installed ARM radars, particularly the X-band polarimetric data, and additionally assessed automatic radial velocity unfolding algorithms developed by other ASR researchers. We focused our efforts on four cases from the MC3E field campaign in 2011 and developed a dataset including microphysical information derived from hydrometeor identification and kinematic analysis using multiple-Doppler retrieval techniques. This dataset became a PI product and was released to the community in 2014. This analysis was used to investigate the source of big drops (> 5 mm) observed with disdrometers at the surface. It was found that the big drops were coincident with the strongest updrafts, suggesting they resulted from the melting of large precipitation ice, likely hail. We teamed up with W-K Tao and T. Matsui to statistically compare radar-derived observational kinematics and microphysics to WRF model output for the 25 April 2011. Comparisons highlighted some areas where the model may need improvement, such as generating too much hail and big drops, as well as overly-strong updrafts and overly-weak of downdrafts.

  10. Greek Orthodox fasting rituals: a hidden characteristic of the Mediterranean diet of Crete.

    PubMed

    Sarri, Katerina O; Linardakis, Manolis K; Bervanaki, Frosso N; Tzanakis, Nikolaos E; Kafatos, Anthony G

    2004-08-01

    The longevity and excellent health status of the population of Crete has been attributed to its lifestyle and dietary habits. The impact of Greek Orthodox Christian Church fasting on these dietary habits has never been studied. One hundred and twenty Greek Orthodox Christians living in Crete participated in a 1-year prospective study. One half of the subjects, who fasted regularly (fasters), and sixty non-faster controls were followed longitudinally for the three main fasting periods over 1 year; Christmas (40 d), Lent (48 d) and the Assumption (15 d). Pre- and end-holy days measurements were performed in each fasting period including: 24 h dietary recall, blood collection and anthropometric measurements. Based on the 24 h recall, fasters as compared with controls had lower intakes of end-holy days dietary cholesterol, total fat, saturated fatty acids, trans-fatty acids and protein (P < 0.001). Fasters presented a decrease of 753 kJ (180 kcal) in end-holy days energy intake (P < 0.05) compared with an increase of 573 kJ (137 kcal) in the controls (P < 0.05). Fasters had a decrease in end-holy days Ca intake (P < 0.001) and an increase in end-holy days total dietary fibre (P < 0.001) and folate (P < 0.05), attributed to their higher consumption of fruit and vegetables in end-holy periods (P < 0.001). There were no differences for other vitamins or minerals between pre- and end-holy periods in both groups except for vitamin B2. The Orthodox Christian dietary regulations are an important component of the Mediterranean diet of Crete characterised by low levels of dietary saturated fatty acids, high levels of fibre and folate, and a high consumption of fruit, vegetables and legumes.

  11. The impact of religious fasting on human health.

    PubMed

    Trepanowski, John F; Bloomer, Richard J

    2010-01-01

    The past two decades have seen a rise in the number of investigations examining the health-related effects of religiously motivated fasts. Islamic Ramadan is a 28 - 30 day fast in which food and drink are prohibited during the daylight hours. The majority of health-specific findings related to Ramadan fasting are mixed. The likely causes for these heterogeneous findings are the differences between studies in the following: 1) the amount of daily fasting time; 2) the percentage of subjects who smoke, take oral medications, and/or receive intravenous fluids; and 3) the subjects' typical food choices and eating habits. Greek Orthodox Christians fast for a total of 180 - 200 days each year, and their main fasting periods are the Nativity Fast (40 days prior to Christmas), Lent (48 days prior to Easter), and the Assumption (15 days in August). The fasting periods are more similar than dissimilar, and they can each be described as a variant of vegetarianism. Some of the more favorable effects of these fasts include the lowering of body mass, total cholesterol, LDL-C, and the LDL-C/HDL-C ratio. The Biblical-based Daniel Fast prohibits the consumption of animal products, refined carbohydrates, food additives, preservatives, sweeteners, flavorings, caffeine, and alcohol. It is most commonly partaken for 21 days, although fasts of 10 and 40 days have been observed. Our initial investigation of the Daniel Fast noted favorable effects on several health-related outcomes, including: blood pressure, blood lipids, insulin sensitivity, and biomarkers of oxidative stress. This review summarizes the health-specific effects of these fasts and provides suggestions for future research.

  12. UNITED NATION'S RESOLUTION ON ELIMINATION OF FEMALE GENITAL RITUAL: A LEGITIMATE RESPONSE TO A HUMAN RIGHTS PROBLEM OR WHAT?

    PubMed

    Nnamuchi, Obiajulu

    2014-12-01

    A recent United Nations' (U.N.) Resolution, "Intensifying Global Efforts for the Elimination of Female Genital Mutilations," urging all countries to enact legislation outlawing female circumcision or female genital ritual (FGR) signals a disturbingly new frontier in the polemic surrounding the ancient cultural practice. Never before has the apex global institution lent its imprimatur to a project whose foundation is profoundly muddled in uncertainties and murkiness. That the Resolution received an instantaneous and near-universal acclaim as a necessary protective weapon against supposed assault on the human rights of women is not news. After all, aside from essentially validating extant legislative frameworks in several countries, the proclamation fits seamlessly with decades-long agitations of activists, scholars and media pundits of one stripe or the other. What is absurd--indeed, the real news--is continued neglect of calls for a rethinking of the criminalization fervor currently gripping the world, for a reassessment of the evidence trumpeted by abolitionists as justificatory of their unbridled interference in what practicing communities revere as a sacred cultural rite. Relying on the premise that claims regarding harmful impact of FGR, the fulcrum upon which eradication forces depend for their activism, cannot be substantiated, this paper argues that prohibitory regimes based thereon, whether at the U.N. or country level, is per se a violation of the human rights of the women purportedly sought to be protected. Human rights (including, in this case, its self-appointed "apostles"), cannot, as a popular Igbo maxim admonishes, become "outsiders who wept louder than the bereaved." This is the prism from which this paper analyzes the on-going supranational crusade to suppress FGR. It is a critique of extant FGR legal and policy regimes, an instance of which is the U.N. Resolution, as unrepresentative of legitimate advancement of human rights.

  13. The Space Science Suitcase - Instruments for Exploring Space Weather From the Classroom

    NASA Astrophysics Data System (ADS)

    Olafsson, K.; Ostgaard, N.

    2008-12-01

    The aurora and other phenomena in near Earth space are becoming a considerable part of the science curriculum in upper secondary school (high school - age 16 to 19) in Norway. Introducing scientific methods to the young students is an important task of the education, but experimental science experience is to a great extent restricted to simple laboratory exercises under controlled conditions; observations of uncontrollable natural phenomena are generally left to academic scientists and researchers. The Space Physics Group and The Science Education and Outreach Group at The Department of Physics and Technology, University of Bergen, have constructed a "Space Science Suitcase" with a set of simple versions of instruments for monitoring solar and geophysical activity in near Earth space. The contents of the suitcase are: Two solar telescopes, commercial SLR digital camera with a fisheye lens for photographing the aurora, tri-axial magnetometer, Geiger counter, two spectroscopes, GPS-receiver, a laptop for collecting the pictures and measurements, and a manual with suggestions for some relevant experiments. The suitcase is lent to physics classes in upper secondary schools for 3-4 weeks at each school, allowing the students to do their own quantitative observations of sunspots, magnetic disturbances, optical aurora, background radiation etc. Comparison of these observations with online observations from ground based observatories and satellites is an integrated part of the project. The purpose of the experiment is to promote scientific literacy, bring excitement about space phenomena into the classroom, and, finally, to recruit enthusiastic students to university studies in physic and geophysics in general, and space science in particular.

  14. Doctors and baldness: a five thousand year old challenge.

    PubMed

    Campo, Daniele; D'Acunzo, Valeria

    2016-02-01

    The history of trichology follows a thread that continually intersects with that of the history of medicine in general. Even Hippocrates believed that the approach to baldness should be of a medical nature. This confrontation between doctors and hair loss, which has lasted for five thousand years, begins with the invocations of the head physicians in the Egyptian era and ends with the recent institution of postgraduate Master's degrees at Faculties of Medicine and Surgery. The biggest names in medicine concerned themselves with trichology beginning with Hippocrates, who dealt with the topic in his most famous work: the Aphorisms. Even the most celebrated doctors of the Roman era, such as Galen and Pliny the Elder, did not disdain considering hair loss, leaving important scientific contributions before passing on the baton to their distinguished colleagues of the Byzantine Empire. The narrative then flows through the most prestigious institutions of the Middle Ages, such as the Salerno School of Medicine and the Siena Accademia del Fisiocritici where, at the end of the 1600s, the distinguished anatomical describer Marcello Malpighi also taught trichology, and left his contribution to "Hair Science" with a fine description of the hair follicle in the pages of his Opera Posthuma. At the turn of the late Middle Ages and the early modern era, barbers formed the primordial nucleus of surgery and at the same time became the ones to concern themselves with hair loss. In the 1800s, several doctors published the first texts dealing with the anatomy and physiology of the hair and taking into account the principal forms of alopecia, but at the therapeutic level did not yet propose anything scientifically valid. Until a few decades ago trichology still lent itself to various commercial speculations. It was not until the twentieth century that the pathogenetic mechanisms of baldness were clarified in a scientific manner. With this knowledge, the pharmaceutical industry has been

  15. Advanced glycation end products promote differentiation of CD4(+) T helper cells toward pro-inflammatory response.

    PubMed

    Han, Xiao-qun; Gong, Zuo-jiong; Xu, San-qing; Li, Xun; Wang, Li-kun; Wu, Shi-min; Wu, Jian-hong; Yang, Hua-fen

    2014-02-01

    This study investigated the effect of advanced glycation end products (AGEs) on differentiation of naïve CD4(+) T cells and the role of the receptor of AGEs (RAGE) and peroxisome proliferator-activated receptors (PPARs) activity in the process in order to gain insight into the mechanism of immunological disorders in diabetes. AGEs were prepared by the reaction of bovine serum albumin (BSA) with glucose. Human naïve CD4(+) T cells, enriched from blood of healthy adult volunteers with negative selection assay, were cultured in vitro and treated with various agents including AGEs, BSA, high glucose, PGJ2 and PD68235 for indicated time. In short hairpin (sh) RNA knock-down experiment, naïve CD4(+) T cells were transduced with media containing shRNA-lentivirus generated from lentiviral packaging cell line, Lent-X(TM) 293 T cells. Surface and intracellular cytokine stainings were used for examination of CD4(+) T cell phenotypes, and real-time PCR and Western blotting for detection of transcription factor mRNA and protein expression, respectively. The suppressive function of regulatory T (Treg) cells was determined by a [(3)H]-thymidine incorporation assay. The results showed that AGEs induced higher pro-inflammatory Th1/Th17 cells differentiated from naïve CD4(+) T cells than the controls, whereas did not affect anti-inflammatory Treg cells. However, AGEs eliminated suppressive function of Treg cells. In addition, AGEs increased RAGE mRNA expression in naïve CD4(+) T cells, and RAGE knock-down by shRNA eliminated the effect of AGEs on the differentiation of CD4(+) T cells and the reduction of suppressive function of Treg cells. Furthermore, AGEs inhibited the mRNA expression of PPARγ, not PPARα PPARγ agonist, PGJ2, inhibited the effect of AGEs on naïve CD4(+) T cell differentiation and reversed the AGE-reduced suppressive function of Treg cells; on the other hand, PPARγ antagonist, PD68235, attenuated the blocking effect of RAGE shRNA on the role of AGEs. It

  16. Innovations from the Integrated Family Planning and Parasite Control Project: PDA experience.

    PubMed

    Phawaphutanond, P

    1990-04-01

    Since 1976, the Integrated Family Planning and Parasite Control (IP) has been conducted by the Population and Community Development Association (PDA) through the financial support of the Japanese Organization for International Cooperation in Family Planning (JOICFP). Family planning was integrated with other activities starting with parasite control and then environmental sanitation. In 1976, PDAs activities were focused on a community-based delivery (CBD) system for contraception in rural Thailand. In the IPs first years, the PDA conducted mass treatment campaigns using both the local plant "maklua" and modern medicines. Various motivational activities were included, such as letting children see the parasites under a microscope. Many villagers showed up for treatment. Later, however, they were reinfected and failed to get further treatment. Since 1981, the major emphasis of the IP rural program has been to push building of latrines and improved water resources. PDA has started a major project for safe storage of rainwater. Some 11,300 liter bamboo-reinforced concrete rainwater storage tanks are being built in northeast Thailand. Giant water jars for rainwater catchment with a 2000-liter capacity are produced. The financing of PDAs environmental sanitation construction activities is unique. Villagers pay back the cost of the raw materials of the tank, latrine, or jar they received. Repayments go into a revolving fund which can be lent to other families. Peer pressure has made repayment levels approach or exceed 100% in target districts. Villagers are trained to produce the casings, bricks, and other things needed for building. Individuals from building crews are selected and given special training in construction techniques and are taught the potential health benefits of each activity. These people become village sanitation engineers. Villagers can engage in income-generating activities and receive technical assistance from the PDA. The IP has taken on a community

  17. Clinical practice guideline: management of acute pancreatitis

    PubMed Central

    Greenberg, Joshua A.; Hsu, Jonathan; Bawazeer, Mohammad; Marshall, John; Friedrich, Jan O.; Nathens, Avery; Coburn, Natalie; May, Gary R.; Pearsall, Emily; McLeod, Robin S.

    2016-01-01

    There has been an increase in the incidence of acute pancreatitis reported worldwide. Despite improvements in access to care, imaging and interventional techniques, acute pancreatitis continues to be associated with significant morbidity and mortality. Despite the availability of clinical practice guidelines for the management of acute pancreatitis, recent studies auditing the clinical management of the condition have shown important areas of noncompliance with evidence-based recommendations. This underscores the importance of creating understandable and implementable recommendations for the diagnosis and management of acute pancreatitis. The purpose of the present guideline is to provide evidence-based recommendations for the management of both mild and severe acute pancreatitis as well as the management of complications of acute pancreatitis and of gall stone–induced pancreatitis. Une hausse de l’incidence de pancréatite aiguë a été constatée à l’échelle mondiale. Malgré l’amélioration de l’accès aux soins et aux techniques d’imagerie et d’intervention, la pancréatite aiguë est toujours associée à une morbidité et une mortalité importantes. Bien qu’il existe des guides de pratique clinique pour la prise en charge de la pancréatite aiguë, des études récentes sur la vérification de la prise en charge clinique de cette affection révèlent des lacunes importantes dans la conformité aux recommandations fondées sur des données probantes. Ces résultats mettent en relief l’importance de formuler des recommandations compréhensibles et applicables pour le diagnostic et la prise en charge de la pancréatite aiguë. La présente ligne directrice vise à fournir des recommandations fondées sur des données probantes pour la prise en charge de la pancréatite aiguë, qu’elle soit bénigne ou grave, ainsi que de ses complications et de celles de la pancréatite causée par un calcul biliaire. PMID:27007094

  18. Doctors and baldness: a five thousand year old challenge.

    PubMed

    Campo, Daniele; D'Acunzo, Valeria

    2016-02-01

    The history of trichology follows a thread that continually intersects with that of the history of medicine in general. Even Hippocrates believed that the approach to baldness should be of a medical nature. This confrontation between doctors and hair loss, which has lasted for five thousand years, begins with the invocations of the head physicians in the Egyptian era and ends with the recent institution of postgraduate Master's degrees at Faculties of Medicine and Surgery. The biggest names in medicine concerned themselves with trichology beginning with Hippocrates, who dealt with the topic in his most famous work: the Aphorisms. Even the most celebrated doctors of the Roman era, such as Galen and Pliny the Elder, did not disdain considering hair loss, leaving important scientific contributions before passing on the baton to their distinguished colleagues of the Byzantine Empire. The narrative then flows through the most prestigious institutions of the Middle Ages, such as the Salerno School of Medicine and the Siena Accademia del Fisiocritici where, at the end of the 1600s, the distinguished anatomical describer Marcello Malpighi also taught trichology, and left his contribution to "Hair Science" with a fine description of the hair follicle in the pages of his Opera Posthuma. At the turn of the late Middle Ages and the early modern era, barbers formed the primordial nucleus of surgery and at the same time became the ones to concern themselves with hair loss. In the 1800s, several doctors published the first texts dealing with the anatomy and physiology of the hair and taking into account the principal forms of alopecia, but at the therapeutic level did not yet propose anything scientifically valid. Until a few decades ago trichology still lent itself to various commercial speculations. It was not until the twentieth century that the pathogenetic mechanisms of baldness were clarified in a scientific manner. With this knowledge, the pharmaceutical industry has been

  19. Prevalence of Antibodies to Hepatitis E Virus in Veterinarians Working with Swine and in Normal Blood Donors in the United States and Other Countries

    PubMed Central

    Meng, X. J.; Wiseman, B.; Elvinger, F.; Guenette, D. K.; Toth, T. E.; Engle, R. E.; Emerson, S. U.; Purcell, R. H.

    2002-01-01

    Hepatitis E virus (HEV) is endemic in many developing and some industrialized countries. It has been hypothesized that animals may be the source of infection. The recent identification of swine HEV in U.S. pigs and the demonstration of its ability to infect across species have lent credence to this hypothesis. To assess the potential risk of zoonotic HEV infection, we tested a total of 468 veterinarians working with swine (including 389 U.S. swine veterinarians) and 400 normal U.S. blood donors for immunoglobulin G anti-HEV. Recombinant capsid antigens from a U.S. strain of swine HEV and from a human HEV strain (Sar-55) were each used in an enzyme-linked immunosorbent assay. The anti-HEV prevalence assayed with the swine HEV antigen showed 97% concordance with that obtained with the human HEV antigen (κ = 92%). Among the 295 swine veterinarians tested from the eight U.S. states (Minnesota, Indiana, Nebraska, Iowa, Illinois, Missouri, North Carolina, and Alabama) from which normal blood donor samples were available, 26% were positive with Sar-55 antigen and 23% were positive with swine HEV antigen. In contrast, 18% of the blood donors from the same eight U.S. states were positive with Sar-55 antigen and 17% were positive with swine HEV antigen. Swine veterinarians in the eight states were 1.51 times more likely when tested with swine HEV antigen (95% confidence interval, 1.03 to 2.20) and 1.46 times more likely when tested with Sar-55 antigen (95% confidence interval, 0.99 to 2.17) to be anti-HEV positive than normal blood donors. We did not find a difference in anti-HEV prevalence between veterinarians who reported having had a needle stick or cut and those who had not or between those who spent more time (≥80% of the time) and those who spent less time (≤20% of the time) working with pigs. Similarly, we did not find a difference in anti-HEV prevalence according to four job categories (academic, practicing, student, and industry veterinarians). There was a

  20. MERIS albedo data set with improved spatial resolution for SCIAMACHY NO2 retrieval over the European Alpine region

    NASA Astrophysics Data System (ADS)

    Popp, Christoph; Brunner, Dominik; Zhou, Yipin; Wang, Ping; Stammes, Piet

    Despite NOx emissions have been reduced in the past two decades in Switzerland, the NO2 concentrations today still occasionally exceed their threshold as in most other European coun-tries. In addition, the neighboring Po Valley in Northern Italy is well known for generally high levels of air pollutants which are often transported to the southern part of Switzerland. Vertical tropospheric column (VTC) densities of NO2 obtained from spaceborne UV/VIS sensors pro-vide spatially homogeneous information complementing local ground-based measurements. For instance, SCIAMACHY (Scanning Imaging Absorption SpectroMeter for Atmospheric Cartog-raphY) derived NO2-VTC are available from 2002 onward potentially enabling trend analysis as well as monitoring of air quality in our region of interest. In general, a large part of the NO2-VTC retrieval uncertainty can be assigned to the air mass factor which, in turn, depends on model parameters such as surface albedo, surface pressure, cloud fraction and cloud pres-sure. Previous studies indicated that improving the spatial resolution of these forward param-eters can lead to more accurate estimates of NO2-VTC. Herein, we concentrate on the surface albedo. In ESA's TEMIS (Tropospheric Emission Monitoring Internet Service) project, the SCIAMACHY NO2-VTC retrieval makes use of combined GOME/TOMS Lambertian equiva-lent reflectance data mapped onto a grid with a spatial resolution of 1x1. However, variations of surface albedo at the scale of individual satellite pixels (30x60km2 for SCIAMACHY) are difficult to be resolved with this grid size, especially in areas like the European Alps and ad-jacent regions characterized by heterogeneous land cover. For these reasons, we compiled a new land surface albedo climatology for each month of the year from MERIS (The Medium Resolution Imaging Spectrometer) Albedomap data covering the period October 2002 to Oc-tober 2006 with a spatial resolution of 0.25x0.25. The wavelength bands considered are

  1. Final Project Report for project titled "Fluoroalkylphosphonic-acid-based proton conductors"

    SciTech Connect

    Stephen Creager

    2011-12-08

    unexpected polymer crosslinking effect of acidic groups having two P-OH groups. The project has lent insight into how FPA groups transport protons in both liquid and polymeric forms, which provides guidance to future efforts to design and prepare future generations of proton-conducting polymer electrolytes for hydrogen fuel cells and other types of electrochemical energy conversion and storage devices.

  2. Detecting Macroevolutionary Self-Destruction from Phylogenies.

    PubMed

    Bromham, Lindell; Hua, Xia; Cardillo, Marcel

    2016-01-01

    Phylogenetic analyses have lent support to the concept of lineage selection: that biological lineages can have heritable traits that influence their capacity to persist and diversify, and thereby affect their representation in biodiversity. While many discussions have focused on "positive" lineage selection, where stably heritable properties of lineages enhance their diversification rate, there are also intriguing examples that seem to represent "negative" lineage selection, where traits reduce the likelihood that a lineage will persist or speciate. In this article, we test whether a particular pattern of negative lineage selection is detectable from the distributions of the trait on a phylogeny. "Self-destructive" traits are those that arise often but then disappear again because they confer either a raised extinction rate or they are prone to a high rate of trait loss. For such a trait, the reconstructed origins will tend to be dispersed across the tips of the phylogeny, rather than defining large clades of related lineages that all share the trait. We examine the utility of four possible measures of "tippiness" as potential indicators of macroevolutionary self-destruction, applying them to phylogenies on which trait evolution has been simulated under different combinations of parameters for speciation, extinction, trait gain, and trait loss. We use an efficient simulation approach that starts with the required number of tips with and without the trait and uses a model to work "backwards" to construct different possible trees that result in that set of tips. We then apply these methods to a number of case studies: salt tolerance in grasses, color polymorphism in birds of prey, and selfing in nightshades. We find that the relative age of species, measured from tip length, can indicate a reduced speciation rate but does not identify traits that increase the extinction rate or the trait loss rate. We show that it is possible to detect cases of macroevolutionary self

  3. Molecular, genetic and transcriptional evidence for a role of VvAGL11 in stenospermocarpic seedlessness in grapevine

    PubMed Central

    2011-01-01

    Background Stenospermocarpy is a mechanism through which certain genotypes of Vitis vinifera L. such as Sultanina produce berries with seeds reduced in size. Stenospermocarpy has not yet been characterized at the molecular level. Results Genetic and physical maps were integrated with the public genomic sequence of Vitis vinifera L. to improve QTL analysis for seedlessness and berry size in experimental progeny derived from a cross of two seedless genotypes. Major QTLs co-positioning for both traits on chromosome 18 defined a 92-kb confidence interval. Functional information from model species including Vitis suggested that VvAGL11, included in this confidence interval, might be the main positional candidate gene responsible for seed and berry development. Characterization of VvAGL11 at the sequence level in the experimental progeny identified several SNPs and INDELs in both regulatory and coding regions. In association analyses performed over three seasons, these SNPs and INDELs explained up to 78% and 44% of the phenotypic variation in seed and berry weight, respectively. Moreover, genetic experiments indicated that the regulatory region has a larger effect on the phenotype than the coding region. Transcriptional analysis lent additional support to the putative role of VvAGL11's regulatory region, as its expression is abolished in seedless genotypes at key stages of seed development. These results transform VvAGL11 into a functional candidate gene for further analyses based on genetic transformation. For breeding purposes, intragenic markers were tested individually for marker assisted selection, and the best markers were those closest to the transcription start site. Conclusion We propose that VvAGL11 is the major functional candidate gene for seedlessness, and we provide experimental evidence suggesting that the seedless phenotype might be caused by variations in its promoter region. Current knowledge of the function of its orthologous genes, its expression

  4. Carbide derived carbon from MAX-phases and their separation applications

    NASA Astrophysics Data System (ADS)

    Hoffman, Elizabeth N.

    Improved sorbents with increased selectivity and permeability are needed to meet growing energy and environmental needs. New forms of carbon based sorbents have been discovered recently, including carbons produced by etching metals from metal carbides, known as carbide derived carbons (CDCs). A common method for the synthesis of CDC is by chlorination at elevated temperatures. The goal of this work is to synthesize CDC from ternary carbides and to explore the links between the initial carbide chemistry and structure with the resulting CDCs properties, including porosity. CDC was produced from MAX-phase carbides, in particular Ti3SiC 2, Ti3AlC2, Ti2AlC, and Ta2AlC. Additionally, CDC was produced from Ta-based binary carbides, TaC and Ta 2C, and one carbo-nitride Ti2AlC0.5N0.5. The CDC structure was characterized using XRD, Raman microspectroscopy, and HRTEM. Porosity characterization was performed using sorption analysis with both Ar and N2 as adsorbates. It was determined the microporosity of CDC is related to the density of the initial carbide. The layered structure of the MAX-phase carbides lent toward the formation of larger mesopores within the resulting CDCs, while the amount of mesopores was dependent on the chemistry of the carbide. Furthermore, CDC produced from carbides with extremely high theoretical porosity resulted in small specific surface areas due to a collapse of the carbon structure. To expand the potential applications for CDC beyond powder and bulk forms, CDC membranes were produced from a thin film of TiC deposited by magnetron sputtering onto porous ceramic substrates. The TiC thin film was subsequently chlorinated to produce a bilayer membrane with CDC as the active layer. Both gases and liquids are capable of passing the membrane. The membrane separates based on selective adsorption, rather than a size separation molecular sieving effect. Two applications for CDC produced from MAX-phases were investigated: protein adsorption and gas

  5. Magnetic Flux Concentrations in Stratified Turbulent Plasma Due to Negative Effective Magnetic Pressure Instability

    NASA Astrophysics Data System (ADS)

    Jabbari, Sarah

    2015-08-01

    We study a system of a highly stratified turbulent plasma. In such a system, when the magnetic Reynolds number is large enough and there is a background field of suitable strength, a new effect will play role in con- centrating magnetic fields such that it leads to the formation of magnetic spots and bipolar regions. This effect is due to the fact that the turbu- lent pressure is suppressed by the large-scale magnetic field, which adds a negative term to the total mean-field (effective) pressure. This leads to an instability, which is known as the negative effective magnetic pressure instability (NEMPI). Direct numerical simulations (DNS) of isothermally forced turbulence have shown that NEMPI leads to the formation of spots in the presence of an imposed field. Our main aim now is to use NEMPI to explain the formation of active regions and sunspots. To achieve this goal, we need to move progressively to more realistic models. Here we extend our model by allowing the magnetic field to be generated by a dy- namo. A dynamo plays an important role in solar activity. Therefore, it is of interest to investigate NEMPI in the presence of dynamo-generated magnetic fields. Mean-field simulations (MFS) of such systems in spheri- cal geometry have shown how these two instabilities work in concert. In fact NEMPI will be activated as long as the strength of the magnetic field generated by the dynamo is in a proper range (for more detail see Jab- bari et al. 2013). In our new study, we use DNS to investigate a similar system. The turbulence is forced in the entire spherical shell, but the forc- ing is made helical in the lower 30% of the shell, similar to the model of Mitra et al. (2014). We perform simulations using the Pencil Code for different density contrasts and other input parameters. We applied ver- tical field boundary conditions in the r direction. The results show that, when the stratification is high enough, intense bipolar regions form and as time passes, they expand

  6. Photonic band gap materials

    NASA Astrophysics Data System (ADS)

    Cassagne, D.

    Photonic band gap materials Photonic band gap materials are periodic dielectric structures that control the propagation of electromagnetic waves. We describe the plane wave method, which allows to calculate the band structures of photonic crystals. By symmetry analysis and a perturbative approach, we predict the appearance of the low energy photonic band gaps of hexagonal structures. We propose new two-dimensional structures called graphite and boron nitride. Using a transfer matrix method, we calculate the transmission of the graphite structure and we show the crucial role of the coupling with external modes. We study the appearance of allowed modes in the photonic band gap by the introduction of localized defects in the periodicity. Finally, we discuss the properties of opals formed by self-organized silica microspheres, which are very promising for the fabrication of three-dimensional photonic crystals. Les matériaux à bandes interdites photoniques sont des structures diélectriques périodiques qui contrôlent la propagation des ondes électromagnétiques. Nous décrivons la méthode des ondes planes qui permet de calculer les structures de bandes des cristaux photoniques. Par une analyse de la symétrie et une approche perturbative, nous précisons les conditions d'existence des bandes interdites de basse énergie. Nous proposons de nouvelles structures bidimensionnelles appelées graphite et nitrure de bore. Grâce à une méthode de matrices de transfert, nous calculons la transmission de la structure graphite et nous mettons en évidence le rôle fondamental du couplage avec les modes extérieurs. Nous étudions l'apparition de modes permis dans la bande interdite grâce à l'introduction de défauts dans la périodicité. Enfin, nous discutons les propriétés des opales constituées de micro-billes de silice auto-organisées, qui sont très prometteuses pour la fabrication de cristaux photoniques tridimensionnels.

  7. Do seasonal patterns of rat snake (Pantherophis obsoletus) and black racer (Coluber constrictor) activity predict avian nest predation?

    PubMed

    DeGregorio, Brett A; Weatherhead, Patrick J; Ward, Michael P; Sperry, Jinelle H

    2016-04-01

    Avian nest success often varies seasonally and because predation is the primary cause of nest failure, seasonal variation in predator activity has been hypothesized to explain seasonal variation in nest success. Despite the fact that nest predator communities are often diverse, recent evidence from studies of snakes that are nest predators has lent some support to the link between snake activity and nest predation. However, the strength of the relationship has varied among studies. Explaining this variation is difficult, because none of these studies directly identified nest predators, the link between predator activity and nest survival was inferred. To address this knowledge gap, we examined seasonal variation in daily survival rates of 463 bird nests (of 17 bird species) and used cameras to document predator identity at 137 nests. We simultaneously quantified seasonal activity patterns of two local snake species (N = 30 individuals) using manual (2136 snake locations) and automated (89,165 movements detected) radiotelemetry. Rat snakes (Pantherophis obsoletus), the dominant snake predator at the site (~28% of observed nest predations), were most active in late May and early June, a pattern reported elsewhere for this species. When analyzing all monitored nests, we found no link between nest predation and seasonal activity of rat snakes. When analyzing only nests with known predator identities (filmed nests), however, we found that rat snakes were more likely to prey on nests during periods when they were moving the greatest distances. Similarly, analyses of all monitored nests indicated that nest survival was not linked to racer activity patterns, but racer-specific predation (N = 17 nests) of filmed nests was higher when racers were moving the greatest distances. Our results suggest that the activity of predators may be associated with higher predation rates by those predators, but that those effects can be difficult to detect when nest predator communities

  8. Kinematics of I Zwicky 18 and Companion Galaxy

    NASA Astrophysics Data System (ADS)

    Dufour, R. J.; Shopbell, P. L.

    1998-05-01

    We present preliminary results of deep Fabry-Perot imaging of ionized gas in the most metal-poor starburst galaxy known, I Zwicky 18, and of an emission ring in the possible companion Im galaxy to the NW. The observations were made in 1997 February using the Maryland-Caltech Fabry-Perot interferometer on the Palomar 200-inch telescope. Using an etalon kindly lent us by J. Bland-Hawthorn of the AAO, we were able to obtain ~ 14 km s(-1) velocity resolution imagery of the Hα emission in I Zw 18 over a +/-250 km s(-1) velocity range around its mean radial velocity (+750 km s(-1) ). This velocity resolution is higher than in recent optical studies of the kinematics of this galaxy. We present maps of the spatial velocity structure at roughly 0.8'' seeing-limited resolution and compare the kinematics with the morphology of the ionized gas and young stars evident from HST WFPC2 images in Hα , [O iii], and BVR bandpasses. We interpret the complex velocity components resolved in terms of the interplay between starbursts, local stellar winds, large superbubbles, and the possible tidal effects from a nearby companion Im galaxy of comparable mass. We also compare and contrast our results to those of two other recent investigations. Ultimately, our goal is to construct a model relating the observed ionized gas kinematics to the recent star formation history of I Zw 18 evident from analysis of the HST imagery. In addition, we present medium resolution optical spectra of the faint ring nebula in the companion galaxy obtained in 1998 March with the Keck II telescope. We confirm previous reports that the emission lines appear only to be Balmer H i lines with no [O ii] or [O iii] detected. The likelyhood that it is a non-radiative SNR is suggested. This study was supported in part by AURA/STScI grants GO-5434, GO-5915, and GO-6826 to Rice University and/or Caltech.

  9. Hypofractionated Intensity-Modulated Arc Therapy for Lymph Node Metastasized Prostate Cancer

    SciTech Connect

    Fonteyne, Valerie; De Gersem, Werner; De Neve, Wilfried; Jacobs, Filip; Lumen, Nicolaas; Vandecasteele, Katrien; Villeirs, Geert; De Meerleer, Gert

    2009-11-15

    Purpose: To determine the planning results and acute toxicity after hypofractionated intensity-modulated arc radiotherapy and androgen deprivation for lymph node metastasized (Stage N1) prostate cancer. Methods and Materials: A total of 31 patients with Stage T1-T4N1M0 prostate cancer were treated with intensity-modulated arc radiotherapy and 3 years of androgen deprivation as primary treatment. The clinical target volume (CTV{sub p}) was the prostate and seminal vesicles. Elective lymph node areas ({sub e}) were delineated and expanded by 2 mm to create the CTV{sub e}. The planning target volumes (PTV{sub p} and PTV{sub e}) were created using a three-dimensional expansion of the CTV{sub p} and CTV{sub e}, respectively, of 7 mm. A median dose of 69.3 Gy and 50 Gy was prescribed to the PTV{sub p} and PTV{sub e} respectively, to be delivered in 25 fractions. Upper and lower gastrointestinal toxicity was scored using the Radiation Therapy Oncology Group toxicity and radiotherapy-induced lower intestinal toxicity scoring system. Genitourinary toxicity was scored using a combined Radiation Therapy Oncology Group, LENT-SOMA (late effects normal tissue-subjective, objective, management, analytic), and Common Toxicity Criteria toxicity scoring system. Results: The median follow-up time was 3 months. The mean prescription dose to the CTV{sub p} and PTV{sub p} was 70.4 Gy and 68.6 Gy, respectively. The minimal dose to the CTV{sub e} and PTV{sub e} was 49.0 Gy and 47.0 Gy, respectively. No acute Grade 2 or greater gastrointestinal toxicity occurred. Fourteen patients developed acute Grade 2 lower gastrointestinal toxicity. Acute Grade 3 and 2 genitourinary toxicity developed in 2 and 14 patients, respectively. Conclusion: The results of our study have shown that hypofractionated intensity-modulated arc radiotherapy as primary therapy for N1 prostate cancer is feasible with low toxicity.

  10. Arts-inspired students sync their assets to a nuts and bolts world: A career mentoring pilot progam

    NASA Astrophysics Data System (ADS)

    Hudson, Lynn

    This research examined how students who are arts-inspired feel about their futures in a STEM-based work climate. Science, Technology, Engineering, and Math are the nuts and bolts, and in education today, the only avenue touted for our country and our students' success in this 21st century economy. This can be disconcerting to those interested in other fields, like the arts. This study was guided by the following questions in an effort to understand if our artists and arts-inspired students realize their options and importance in this 21st century climate. The pilot study was designed to help improve the students' perception of their abilities or self-efficacy in the STEM areas by introducing STEM professionals as mentors who designed hands-on activities that simulate work in the STEM fields. Research Questions: 1. Do arts-inspired students have an interest in a STEM career area prior to participating in the career mentoring program? 2. Does participation in a STEM career mentoring program improve student's self-efficacy in STEM fields? 3. Does participation in STEM career mentoring program increase student's interest in pursuing STEM-related careers? Lent, Brown and Hackett's Social Cognitive Career Theory and Daniel Pink's, "A Whole New Mind: Why Left-Brainers Will Rule the Future" were used as the theoretical framework for this study. Seventeen African-American girls who were enrolled in the "I AM COMPLETE" summer program participated in the pilot study. Data was collected from the College Foundation of North Carolina Career Interest Explorer and the STEM Career Interest Survey, which served as a pre and post-test. This pilot offered limited support for the hypothesis, however, career mentoring and opportunities for young people to experience careers, especially in the STEM areas must continue to grow. The role that the arts play in this process is pivotal in galvanizing females and minorities to join these professions. It is the hope of this researcher that the

  11. Paleoclimatic modeling and phylogeography of least killifish, Heterandria formosa: insights into Pleistocene expansion-contraction dynamics and evolutionary history of North American Coastal Plain freshwater biota

    PubMed Central

    2013-01-01

    Background Climatic and sea-level fluctuations throughout the last Pleistocene glacial cycle (~130-0 ka) profoundly influenced present-day distributions and genetic diversity of Northern Hemisphere biotas by forcing range contractions in many species during the glacial advance and allowing expansion following glacial retreat ('expansion-contraction’ model). Evidence for such range dynamics and refugia in the unglaciated Gulf-Atlantic Coastal Plain stems largely from terrestrial species, and aquatic species Pleistocene responses remain relatively uninvestigated. Heterandria formosa, a wide-ranging regional endemic, presents an ideal system to test the expansion-contraction model within this biota. By integrating ecological niche modeling and phylogeography, we infer the Pleistocene history of this livebearing fish (Poeciliidae) and test for several predicted distributional and genetic effects of the last glaciation. Results Paleoclimatic models predicted range contraction to a single southwest Florida peninsula refugium during the Last Glacial Maximum, followed by northward expansion. We inferred spatial-population subdivision into four groups that reflect genetic barriers outside this refuge. Several other features of the genetic data were consistent with predictions derived from an expansion-contraction model: limited intraspecific divergence (e.g. mean mtDNA p-distance = 0.66%); a pattern of mtDNA diversity (mean Hd = 0.934; mean π = 0.007) consistent with rapid, recent population expansion; a lack of mtDNA isolation-by-distance; and clinal variation in allozyme diversity with higher diversity at lower latitudes near the predicted refugium. Statistical tests of mismatch distributions and coalescent simulations of the gene tree lent greater support to a scenario of post-glacial expansion and diversification from a single refugium than to any other model examined (e.g. multiple-refugia scenarios). Conclusions Congruent results from diverse data

  12. In the foot steps of Madame Curie: A cross-case study of female undergraduate physics majors

    NASA Astrophysics Data System (ADS)

    Jaladanki, Vani Savithri

    Females are disproportionately underrepresented in STEM (science, technology, engineering, and mathematics) majors. Further, the number of females who take physics in college has declined. While female students make up 61% of graduates in biological sciences and 50% in chemistry, the proportion of women completing physics degrees is only 21% (Sawtelle, 2011). In order to improve women's access to science and engineering education, research must focus on personal and environmental factors that motivate them to select these fields (AAUW, 2010). The purpose of this study was to explore how the educational experiences of three female undergraduate physics majors contribute to their current dispositions toward, interest in, and pursuit of physics as a major at a large southern research university. This qualitative study employs symbolic interactionism (Blumer, 1969) as its methodological framework and social cognitive career theory (Lent, Brown, & Hackett, 2002) as its theoretical framework. Case study methods (Yin, 2006) were implemented to investigate the experiences of three participants. The primary sources of data included critical incident interviews (Flanagan, 1954), photographs, documents, object elicitations, and the researcher's reflections. Narrative and arts-based techniques were employed to analyze and represent data. Findings are presented as co-constructed narratives of the participants' journeys to becoming undergraduate physics majors. Three major themes emerged from the cross case analysis: carving new spaces, authoring an empowered self, and show me you care and so will I. The direct experiences of engaging with science at a young age and social persuasions of family members, teachers, and peers strongly influenced the participants' interest in and pursuit of physics. Their current dispositions to physics result from vicarious experiences with professors and peers in combination with the social persuasions of the latter. This study informs science

  13. Stereotactic radiotherapy of meningiomas compressing optical pathways

    SciTech Connect

    Hamm, Klaus-Detlef . E-mail: khamm@erfurt.helios-kliniken.de; Henzel, Martin; Gross, Markus W.; Surber, Gunnar; Kleinert, Gabriele; Engenhart-Cabillic, Rita

    2006-11-15

    Purpose: Microsurgical resection is usually the treatment of choice for meningiomas, especially for those that compress the optical pathways. However, in many cases of skull-base meningiomas a high risk of neurological deficits and recurrences exist in cases where the complete tumor removal was not possible. In such cases (fractionated) stereotactic radiotherapy (SRT) can offer an alternative treatment option. We evaluated the local control rate, symptomatology, and toxicity. Patients and Methods: Between 1997 and 2003, 183 patients with skull-base meningiomas were treated with SRT, among them were 65 patients with meningiomas that compressed optical pathways (64 benign, 1 atypical). Of these 65 cases, 20 were treated with SRT only, 27 were subtotally resected before SRT, and 18 underwent multiple tumor resections before SRT. We investigated the results until 2005, with a median follow-up of 45 months (range, 22-83 months). The tumor volume (TV = gross tumor volume) ranged from 0.61 to 90.20 cc (mean, 18.9 cc). Because of the risk of new visual disturbances, the dose per fraction was either 2 or 1.8 Gy for all patients, to a total dose of 50 to 60 Gy. Results: The overall survival and the progression-free survival rates for 5 years were assessed to 100% in this patient group. To date, no progression for these meningiomas have been observed. Quantitatively, tumor shrinkage of more than 20%, or more than 2 mm in diameter, was proved in 35 of the 65 cases after SRT. In 29 of the 65 patients, at least 1 of the symptoms improved. On application of the Common Toxicity Criteria (CTC), acute toxicity (Grade 3) was seen in 1 case (worsening of conjunctivitis). Another 2 patients developed late toxicity by LENT-SOMA score, 1 x Grade 1 and 1 x Grade 3 (field of vision loss). Conclusion: As a low-risk and effective treatment option for tumor control, SRT with 1.8 to 2.0 Gy per fraction can also be recommended in case of meningiomas that compress optical pathways. An

  14. Effects of scalding and dehairing of pig carcasses at abattoirs on the visibility of welfare-related lesions.

    PubMed

    Carroll, G A; Boyle, L A; Teixeira, D L; van Staaveren, N; Hanlon, A; O'Connell, N E

    2016-03-01

    There is increasing interest in developing abattoir-based measures to assist in determining the welfare status of pigs. The primary aim of this study was to determine the most appropriate place on the slaughter line to conduct assessments of welfare-related lesions, namely apparent aggression-related skin lesions (hereafter referred to as 'skin lesions'), loin bruising and apparent tail biting damage. The study also lent itself to an assessment of the prevalence of these lesions, and the extent to which they were linked with production variables. Finishing pigs processed at two abattoirs on the Island of Ireland (n=1950 in abattoir A, and n=1939 in abattoir B) were used. Data were collected over 6 days in each abattoir in July 2014. Lesion scoring took place at two points on the slaughter line: (1) at exsanguination (slaughter stage 1 (SS1)), and (2) following scalding and dehairing of carcasses (slaughter stage 2 (SS2)). At both points, each carcass was assigned a skin and tail lesion score ranging from 0 (lesion absent) to 3 or 4 (severe lesions), respectively. Loin bruising was recorded as present or absent. Differences in the percentage of pigs with observable lesions of each type were compared between SS1 and SS2 using McNemar/McNemar-Bowker tests. The associations between each lesion type, and both cold carcass weight and condemnations, were examined at batch level using Pearson's correlations. Batch was defined as the group of animals with a particular farm identification code on a given day. The overall percentage of pigs with a visible skin lesion (i.e. score>0) decreased between SS1 and SS2 (P<0.001). However, the percentage of pigs with a severe skin lesion increased numerically from SS1 to SS2. The percentage of pigs with a visible tail lesion and with loin bruising also increased between SS1 and SS2 (P<0.001). There was a positive correlation between the percentage of carcasses that were partially condemned, and the percentage of pigs with skin lesions

  15. Examining the Effects of a STEM Career Video Intervention on the Interests and STEM Professional Identities of Rural, Minority Middle School Students

    NASA Astrophysics Data System (ADS)

    Kier, Meredith Weaver

    National efforts to interest students in STEM careers are intensifying around the globe, due to a shortage of professionals to fill the growing demands in these fields. Although some US studies find high interest in STEM in K-12 students, longitudinal studies show a decline in interest following middle school. Many students, particularly females and minorities, feel that they do not fit the image of a STEM professional. Little is known about perceptions held by students in rural areas, who have limited access to diverse STEM careers. This dissertation study employed an in school STEM career video intervention with eighty-five rural, minority, eighth grade students in a high poverty district in the southeastern US. Research questions explore students' STEM career interests before and after the STEM career video intervention, and analyze how students in this population negotiate a potential identity in STEM. Applying aspects of Lent, Brown, & Hackett's social cognitive career theory (SCCT), students' exploration sheets and video planning sheets were coded to understand positive or negative contributors to STEM career interests. Students' initial explorations were limited to careers to which they had been previously exposed at home or in class, and were influenced by their personal dispositions Over the course of the intervention, increased knowledge of careers increased the diversity of careers selected, attention to educational level, and the influence of more sophisticated career outcomes on interest. Students selected careers based on personal interests and outcome expectations, but were able to identify how their academic strengths, dispositions, and family support systems related to their career goals. Post survey analyses found the presence of role models and high self-efficacy were new predictors of interest. Study results imply that similar interventions can help students gain more sophisticated understandings of careers, can motivate students without

  16. Detecting Macroevolutionary Self-Destruction from Phylogenies.

    PubMed

    Bromham, Lindell; Hua, Xia; Cardillo, Marcel

    2016-01-01

    Phylogenetic analyses have lent support to the concept of lineage selection: that biological lineages can have heritable traits that influence their capacity to persist and diversify, and thereby affect their representation in biodiversity. While many discussions have focused on "positive" lineage selection, where stably heritable properties of lineages enhance their diversification rate, there are also intriguing examples that seem to represent "negative" lineage selection, where traits reduce the likelihood that a lineage will persist or speciate. In this article, we test whether a particular pattern of negative lineage selection is detectable from the distributions of the trait on a phylogeny. "Self-destructive" traits are those that arise often but then disappear again because they confer either a raised extinction rate or they are prone to a high rate of trait loss. For such a trait, the reconstructed origins will tend to be dispersed across the tips of the phylogeny, rather than defining large clades of related lineages that all share the trait. We examine the utility of four possible measures of "tippiness" as potential indicators of macroevolutionary self-destruction, applying them to phylogenies on which trait evolution has been simulated under different combinations of parameters for speciation, extinction, trait gain, and trait loss. We use an efficient simulation approach that starts with the required number of tips with and without the trait and uses a model to work "backwards" to construct different possible trees that result in that set of tips. We then apply these methods to a number of case studies: salt tolerance in grasses, color polymorphism in birds of prey, and selfing in nightshades. We find that the relative age of species, measured from tip length, can indicate a reduced speciation rate but does not identify traits that increase the extinction rate or the trait loss rate. We show that it is possible to detect cases of macroevolutionary self

  17. Pyrexia of unknown origin 90 years on: a paradigm of modern clinical medicine.

    PubMed

    Brown, Michael

    2015-12-01

    In 1925, Sir Thomas Horder, a leading physician of his day, gave a lecture, published in this journal, entitled 'Some cases of pyrexia without physical signs'. The paper highlighted what was already a familiar clinical presentation "which taxes our resources to the utmost". Fast-forward through 90 years of careful clinical description, technological innovation in diagnosis and treatment, emergent infections, novel diagnoses, demographic shifts, and radical changes in the health economy. Sir Thomas would find certain aspects familiar, and others revolutionary, in the differential diagnosis and management of the 21st century patient with pyrexia of unknown origin (PUO). Within high-income settings, the proportion of cases due to infection has declined, albeit unevenly. The era of untreated HIV, and the consequences of iatrogenic intervention and immunosuppression, led to Durack and Street's subclassification of the condition in the early 1990 s into classic, nosocomial, neutropenic and HIV-associated PUO. Shifts towards ambulatory care have driven a change in the definition of many diseases. An era of observant clinicians, who lent their names to eponymous syndromes, followed by meticulous serological, genetic and clinicopathological correlation, generated a battery of diagnoses that, along with malignancy, form a large proportion of diagnoses in more recent clinical care. In the current era, universal access to cross-sectional imaging and an infinite array of laboratory tests has undermined the attention paid to history and examination. In some areas of the clinical assessment, such as assessing the fever pattern, this shift is supported by research evidence. The issues that need to be addressed in the next 90 years of technological innovation, information sharing and health service transformation are likely to include: transcriptomic approaches to diagnosis; the place of positron emission tomography (PET) in the diagnostic pathway; the optimal management of high

  18. Ensino de astronomia e óptica: é possível fazê-lo de forma contextualizada no nível médio?

    NASA Astrophysics Data System (ADS)

    Sobrinho, A. A.; Jafelice, L. C.

    2003-08-01

    Discutimos nossa participação em um curso de treinamento para professores de diversas disciplinas do ensino médio. Nossa preocupação básica foi desenvolver instrumentos educacionais adequados para levar à sala de aula, nesse nível de ensino, de forma contextualizada, questionamentos freqüentes dos alunos sobre astronomia e sua relação com tecnologia e sociedade. Encaminhamos questões como: a evolução da astronomia, suas relações com outros ramos do conhecimento humano e conseqüentes aplicações; avanços na tecnologia dos instrumentos ópticos versus a importância da observação do céu a olho nu; a relação entre olho humano, luneta e telescópio; e desenvolvimento da tecnologia espacial e sua influência em nosso cotidiano. Objetivamos com isto fazer um resgate histórico e pedagógico das aplicações e observações do céu no cenário escolar, destacando a relação entre eventos astronômicos, olho humano, instrumentos mediadores e suas contextualizações históricas e sociais. Produtos desta abordagem foram o desenvolvimento e a adaptação de práticas e materiais instrucionais diversos (e.g., "espelhos" de isopor e "raios luminosos" de bolinhas de gude; montagens envolvendo velas, lasers, lentes e espelhos; desmonte e análise de peças de um telescópio; etc.). Além disto, como outro resultado deste trabalho, elaboramos textos sobre história da astronomia e da óptica para atividades em classe. Com estas ações visamos facilitar a concretização de conceitos físicos envolvidos, exemplificar um ensino contextualizado e interdisciplinar motivado por temas astronômicos e favorecer que práticas e discussões feitas com os treinandos possam ser transpostas para a sala de aula. A reação dos professores às práticas propostas foi bastante positiva. Todos esses aspectos são discutidos em detalhe neste trabalho. (PPGECNM/UFRN; PRONEX/FINEP; NUPA/USP; Temáticos/FAPESP)

  19. Exploring the experiences of female students in introductory project-based engineering courses at two- and four-year institutions

    NASA Astrophysics Data System (ADS)

    Swan, Amy K.

    2011-12-01

    This qualitative study explored the experiential and contextual factors that shaped female students' pathways into introductory project-based engineering classes at two community colleges and one four-year institution, as well as female students' experiences within and outside of these classes. The study was framed by Social Cognitive Career Theory (SCCT) (Lent, Brown & Hackett, 1996) and Bronfenbrenner's (1979) ecological systems theory. Findings were based on analyses of data gathered through multiple methods: observations; individual interviews with female students; focus group interviews with project teams; and document collection. The findings of this study revealed that while positive experiences with math or science were a likely pre-cursor to engineering interest, experiential learning appeared to be a more powerful force in fostering students' engineering interest. Specifically, participants developed an interest in engineering through academic, professional, and extracurricular engineering- and design-related activities that familiarized them with the tasks and skills involved in engineering work and helped them develop a sense of selfefficacy with regard to this work. Interest and self-efficacy, in turn, played a role in students' postsecondary educational decision-making processes, as did contextual factors including families and finances. This study's findings also showed that participants' project teams were a critically important microsystem within participants' ecological environments. Within this sometimes "chilly" microsystem, female students negotiated intrateam processes, which were in some cases affected by gender norms. Intrateam processes that influenced female students' project-based learning experiences included: interpersonal dynamics; leadership; and division of labor. This study also identified several ways in which the lived experiences of participants at the community colleges were different from, or similar to, those of participants

  20. Young, southern women's perceptions of STEM careers: Examining science, technology, engineering & mathematics as a gendered construct

    NASA Astrophysics Data System (ADS)

    Quinton, Jessica Elizabeth

    Career interests develop over a lifetime and tend to solidify during late adolescence and early adulthood (Lent, Brown, and Hackett, 2002). The primary purpose of the present qualitative study, which is framed in Feminist Standpoint Theory (Haraway, 1988; Harding, 2007; Naples, 2007; Richardson, 2007), is to understand how eighth-grade, young women in a suburban, public, southern, middle school the South Carolina County School District (CCSD) (pseudonym) perceive their accessibility to Science, Technology, Engineering, and Mathematics (STEM) courses and careers. The secondary purpose is to understand these young women's "perceptions and unconscious beliefs about gender in science and mathematics" and how their "perceptions and unconscious beliefs about gender" in the STEM fields may impact the careers that these young women may choose in the future (American Association of University Women, 2010, 9). Within the present study, the perceptions of young women who identified as "Interested in Science," "Somewhat Interested in Science" and "Uninterested in Science" were identified. STEM courses and careers are a major emphasis in education today. Increasing the numbers of Americans who pursue STEM careers is a government priority, as these careers will strengthen the economy (AAUW 2010). The present study reveals how young women who are highly motivated, talented students perceive STEM courses and careers and how they are influenced by their experiences, gendered messages, and knowledge of STEM careers. To analyze the data, four of Saldana's (2010) dramaturgical codes were utilized including: 1. OBJectives, or motives; 2. CONflicts the participants faced; 3. TACtics to dealing with obstacles; and 4. ATTitudes toward the setting, others, and the conflict. The InVivo Codes allowed the participants stories to emerge through the set of dramaturgical codes that allowed for viewing the girls' experience sin different ways that added depth to their stories. The young women in

  1. Safety, effectiveness, and cost effectiveness of long acting versus intermediate acting insulin for patients with type 1 diabetes: systematic review and network meta-analysis

    PubMed Central

    Tricco, Andrea C; Ashoor, Huda M; Antony, Jesmin; Beyene, Joseph; Veroniki, Areti Angeliki; Isaranuwatchai, Wanrudee; Harrington, Alana; Wilson, Charlotte; Tsouros, Sophia; Soobiah, Charlene; Yu, Catherine H; Hutton, Brian; Hoch, Jeffrey S; Hemmelgarn, Brenda R; Moher, David; Majumdar, Sumit R

    2014-01-01

    Objective To examine the safety, effectiveness, and cost effectiveness of long acting insulin for type 1 diabetes. Design Systematic review and network meta-analysis. Data sources Medline, Cochrane Central Register of Controlled Trials, Embase, and grey literature were searched through January 2013. Study selection Randomized controlled trials or non-randomized studies of long acting (glargine, detemir) and intermediate acting (neutral protamine Hagedorn (NPH), lente) insulin for adults with type 1 diabetes were included. Results 39 studies (27 randomized controlled trials including 7496 patients) were included after screening of 6501 titles/abstracts and 190 full text articles. Glargine once daily, detemir once daily, and detemir once/twice daily significantly reduced hemoglobin A1c compared with NPH once daily in network meta-analysis (26 randomized controlled trials, mean difference −0.39%, 95% confidence interval −0.59% to −0.19%; −0.26%, −0.48% to −0.03%; and −0.36%, −0.65% to −0.08%; respectively). Differences in network meta-analysis were observed between long acting and intermediate acting insulin for severe hypoglycemia (16 randomized controlled trials; detemir once/twice daily versus NPH once/twice daily: odds ratio 0.62, 95% confidence interval 0.42 to 0.91) and weight gain (13 randomized controlled trials; detemir once daily versus NPH once/twice daily: mean difference 4.04 kg, 3.06 to 5.02 kg; detemir once/twice daily versus NPH once daily: −5.51 kg, −6.56 to −4.46 kg; glargine once daily versus NPH once daily: −5.14 kg, −6.07 to −4.21). Compared with NPH, detemir was less costly and more effective in 3/14 cost effectiveness analyses and glargine was less costly and more effective in 2/8 cost effectiveness analyses. The remaining cost effectiveness analyses found that detemir and glargine were more costly but more effective than NPH. Glargine was not cost effective compared with detemir in 2/2 cost effectiveness analyses

  2. Hilbert problems for the geosciences in the 21st century

    NASA Astrophysics Data System (ADS)

    Ghil, M.

    The scientific problems posed by the Earth's fluid envelope, and its atmosphere, oceans, and the land surface that interacts with them are central to major socio-economic and political concerns as we move into the 21st century. It is natural, therefore, that a certain impatience should prevail in attempting to solve these problems. The point of this review paper is that one should proceed with all diligence, but not excessive haste: "festina lente," as the Romans said two thousand years ago, i.e. "hurry in a measured way." The paper traces the necessary progress through the solutions to the ten problems: 1. What is the coarse-grained structure of low-frequency atmospheric variability, and what is the connection between its episodic and oscillatory description? 2. What can we predict beyond one week, for how long, and by what methods? 3. What are the respective roles of intrinsic ocean variability, coupled ocean-atmosphere modes, and atmospheric forcing in seasonal-to-interannual variability? 4. What are the implications of the answer to the previous problem for climate prediction on this time scale? 5. How does the oceans' thermohaline circulation change on interdecadal and longer time scales, and what is the role of the atmosphere and sea ice in such changes? 6. What is the role of chemical cycles and biological changes in affecting climate on slow time scales, and how are they affected, in turn, by climate variations? 7. Does the answer to the question above give us some trigger points for climate control? 8. What can we learn about these problems from the atmospheres and oceans of other planets and their satellites? 9. Given the answer to the questions so far, what is the role of humans in modifying the climate? 10. Can we achieve enlightened climate control of our planet by the end of the century? A unified framework is proposed to deal with these problems in succession, from the shortest to the longest timescale, i.e. from weeks to centuries and millennia. The

  3. "How can I tell?" Consequences of HIV status disclosure among couples in eastern African communities in the context of an ongoing HIV "test-and-treat" trial.

    PubMed

    Maeri, Irene; El Ayadi, Alison; Getahun, Monica; Charlebois, Edwin; Akatukwasa, Cecilia; Tumwebaze, Dennis; Itiakorit, Harriet; Owino, Lawrence; Kwarisiima, Dalsone; Ssemmondo, Emmanuel; Sang, Norton; Kabami, Jane; Clark, Tamara D; Petersen, Maya; Cohen, Craig R; Bukusi, Elizabeth A; Kamya, Moses; Havlir, Diane; Camlin, Carol S

    2016-01-01

    People living with HIV/AIDS anticipate HIV-related stigma and fear disclosure to intimate partners. Yet, disclosure is critical to reducing HIV transmission and improving care engagement. This qualitative study characterized HIV disclosure experiences and normative beliefs among couples in communities participating in an HIV test-and-treat trial in Kenya and Uganda (Sustainable East Africa Research in Community Health, NCT#01864603). In-depth interviews were conducted with care providers (n = 50), leaders (n = 32) and members (n = 112) of eight communities. Data were analyzed using grounded theoretical approaches and Atlas.ti software. Findings confirmed gender differences in barriers to disclosure: while both men and women feared blame and accusation, women also feared violence and abandonment ("I did not tell my husband because [what if] I tell him and he abandons me at the last moment when I am in labor?"). Positive consequences included partner support for increased care-seeking and adherence ("My husband keeps on reminding me 'have you taken those drugs?'") Yet negative consequences included partnership dissolution, blame, and reports of violence ("some men beat their wives just because of that [bringing HIV medications home]"). Among HIV-infected individuals in discordant relationships, men more often reported supportive spouses ("we normally share [HIV-risk-reduction strategies] since I have been infected and she is HIV negative"), than did women ("my husband refused to use condoms and even threatened to marry another wife"). Care providers lent support for HIV-positive women who wanted to engage partners in testing but feared negative consequences: "They engaged the two of us in a session and asked him if we could all test." Findings demonstrate differing experiences and support needs of women and men living with HIV in eastern Africa, with HIV-positive women in discordant couples particularly vulnerable to negative consequences of disclosure

  4. Norming a VALUE rubric to assess graduate information literacy skills

    PubMed Central

    Turbow, David J.; Evener, Julie

    2016-01-01

    Objective The study evaluated whether a modified version of the information literacy Valid Assessment of Learning in Undergraduate Education (VALUE) rubric would be useful for assessing the information literacy skills of graduate health sciences students. Methods Through facilitated calibration workshops, an interdepartmental six-person team of librarians and faculty engaged in guided discussion about the meaning of the rubric criteria. They applied the rubric to score student work for a peer-review essay assignment in the “Information Literacy for Evidence-Based Practice” course. To determine inter-rater reliability, the raters participated in a follow-up exercise in which they independently applied the rubric to ten samples of work from a research project in the doctor of physical therapy program: the patient case report assignment. Results For the peer-review essay, a high level of consistency in scoring was achieved for the second workshop, with statistically significant intra-class correlation coefficients above 0.8 for 3 criteria: “Determine the extent of evidence needed,” “Use evidence effectively to accomplish a specific purpose,” and “Access the needed evidence.” Participants concurred that the essay prompt and rubric criteria adequately discriminated the quality of student work for the peer-review essay assignment. When raters independently scored the patient case report assignment, inter-rater agreement was low and statistically insignificant for all rubric criteria (kappa=−0.16, p>0.05–kappa=0.12, p>0.05). Conclusions While the peer-review essay assignment lent itself well to rubric calibration, scorers had a difficult time with the patient case report. Lack of familiarity among some raters with the specifics of the patient case report assignment and subject matter might have accounted for low inter-rater reliability. When norming, it is important to hold conversations about search strategies and expectations of performance. Overall

  5. Dermatofibrosarcome de Darier et Ferrand: à propos de 38 cas

    PubMed Central

    El Kacemi, Hanan; Aissa, Abdellah; Bazine, Amine; Kebdani, Tayeb; Bougtab, Abdeslam; Benjaafar, Noureddine

    2014-01-01

    Le dermatofibrosarcome protubérans de Darier et Ferrand est une tumeur cutanée rare. Le but de cette étude est de décrire les aspects épidémiologiques, cliniques, histologiques, thérapeutiques et évolutifs avec comparaison aux données de la littérature. Il s'agissait d'une étude rétrospective sur 10 ans à propos de 38 cas de dermatofibrosarcome de Darier et Ferrand pris en charge à l'Institut National d'Oncologie. Les données épidémiologiques, diagnostiques, thérapeutiques et évolutives ont été recueillies à partir des dossiers cliniques des patients et rapportées sur une fiche préétablie. L’âge médian des patients était de 41,5 ans. Tous les patients avaient une preuve histologique de dermatofibrosarcome. Seulement 30 patients ont été traités à l'Institut National d'Oncologie. L'exérèse chirurgicale de la tumeur était large, avec des marges de sécurité de 6-10 cm chez 6 patients (20%), 5 cm chez 16 patients (53%), 2-3 cm chez 4 patients (13%). En profondeur, l'exérèse emportait une barrière anatomique saine. 5 malades ont bénéficié d'une radiothérapie externe avec une dose médiane de 59,5 Gy. Le recul médian était de 64,4 mois (28- 138 mois). Le dermatofibrosarcome protubérans de Darier et Ferrand est une tumeur se distinguant par son évolution lente, son agressivité locale, son haut pouvoir de récidive et la rareté des métastases. Le traitement consiste en une exérèse large et profonde. Le pronostic dépend essentiellement de la qualité de l'exérèse initiale chirurgicale. La série étudiée présente des similitudes épidémiologiques, cliniques, et thérapeutiques avec les données de la littérature. PMID:25870729

  6. Sources of computer self-efficacy: The relationship to outcome expectations, computer anxiety, and intention to use computers

    NASA Astrophysics Data System (ADS)

    Antoine, Marilyn V.

    2011-12-01

    The purpose of this research was to extend earlier research on sources of selfefficacy (Lent, Lopez, & Biechke, 1991; Usher & Pajares, 2009) to the information technology domain. The principal investigator examined how Bandura's (1977) sources of self-efficacy information---mastery experience, vicarious experience, verbal persuasion, and physiological states---shape computer self-efficacy beliefs and influence the decision to use or not use computers. The study took place at a mid-sized Historically Black College or University in the South. A convenience sample of 105 undergraduates was drawn from students enrolled in multiple sections of two introductory computer courses. There were 67 females and 38 males. This research was a correlational study of the following variables: sources of computer self-efficacy, general computer self-efficacy, outcome expectations, computer anxiety, and intention to use computers. The principal investigator administered a survey questionnaire containing 52 Likert items to measure the major study variables. Additionally, the survey instrument collected demographic variables such as gender, age, race, intended major, classification, technology use, technology adoption category, and whether the student owns a computer. The results reveal the following: (1) Mastery experience and verbal persuasion had statistically significant relationships to general computer self-efficacy, while vicarious experience and physiological states had non-significant relationships. Mastery experience had the strongest correlation to general computer self-efficacy. (2) All of the sources of computer self-efficacy had statistically significant relationships to personal outcome expectations. Vicarious experience had the strongest correlation to personal outcome expectations. (3) All of the sources of self-efficacy had statistically significant relationships to performance outcome expectations. Vicarious experience had the strongest correlation to performance

  7. Observación y registro fotográfico del cometa HYAKUTAKE C/1996 B2

    NASA Astrophysics Data System (ADS)

    Arquiola, A. P.; Arquiola, F. E.

    Desde el momento en que nos llega la información del descubrimiento, comenzamos la observación de forma detallada a fin de apreciar y seguir su creciente actividad. La primera observación se realizó el 17 de febrero de 1996 a las 4h20m UT con nuestro telescopio de 300mm newtoniano de f/6.5, con una muy buena transparencia atmosférica, estimando una magnitud de 8.5. Realizábamos observaciones casi todas las noches, mientras nos lo permitían las condiciones climáticas. Ya el 26 de febrero el cometa presentaba un aspecto muy particular, ligeramente distinto a las primeras observaciones, ya que comenzamos a notar su gran actividad. En primer lugar se destacaba la cola de iones mucho mas extensa que la cola de polvo. Magnitud estimada 7.5. El 19 de marzo ya era visible a simple vista y en especial su cola muy abierta y extensa (3 grados) y no quedaba duda alguna que la última noche de observación del cometa en el horizonte de la Ciudad de Funes, que fue el 24 de marzo de 1996, un día antes del acercamiento a la Tierra, tendríamos una apreciación del cometa en su máximo esplendor. El 24 de marzo de 1996 a las 4hs UT, asomó el cometa por el horizonte NE, con su cola espectacular, llegando a medir 23 grados de longitud, muy recta y brillante, y su cabellera muy estelar. A este marco de observación se sumaron mas de 600 personas que participaron usando instrumentos, siendo la mayoría de los concurrentes de la vecina Ciudad de Rosario, ya que su observación era a muy baja atura sobre el horizonte norte. Instrumentos utilizados : Telescopio Newtoniano 300mm f/6.5, Telescopio Schmidt-Cassegrain 200mm , Binoculares 10 x 50, 7 x 50, Lente normal 50mm a f/1.8, Película 100 - 400 ASA Lugar de Observación : Ciudad de Funes, zona rural, ``Estancia La Polola" Latitud: - 32o 55' Longitud: 60o 40' Oeste

  8. Sistemas Correctores de Campo Para EL Telescopio Cassegrain IAC80

    NASA Astrophysics Data System (ADS)

    Galan, M. J.; Cobos, F. J.

    1987-05-01

    El proyecto de instrumentación de mayor importancia que ha tenido el Instituto de Astrofisica de Canarias en los últimos afios ha sido el diseflo y construcción del te1escopio IAC8O. Este requería del esfuerzo con junto en mec´nica, óptica y electrónica, lo que facilitó la estructuración y el crecimiento de los respectivos grupos de trabajo, que posteriormente se integraron en departamentos En su origen (1977), el telescopio IAC80 fue concebido como un sistema clásico tipo Cassegrain, con una razón focal F/i 1.3 para el sistema Casse grain y una razón focal F/20 para el sistema Coudé. Posteriormente, aunque se mantuvo la filosofia de que el sistema básico fuera el F/11.3, se consideró conveniente el diseño de secundarios para razones focales F/16 y F/32, y se eliminó el de F/20. Sin embargo, dada la importancia relativa que un foco estrictamente fotográfico tiene en un telescopio moderno, diseñado básicamente para fotometría fotoeléctrica y con un campo util mínimamente de 40 minutos de arco, se decídió Ilevar a cabo el diseño de un secundario F/8 con un sistema corrector de campo, pero que estuviera formado únicamente por lentes con superficies esféricas para que asl su construcción fuera posible en España ó en México. La creciente utilización de detectores bidimensionales para fines de investigación astron6mica y la viabilidad de que en un futuro cercano éstos tengan un área sensible cada vez mayor, hicieron atractiva la idea de tener diseñado un sistema corrector de campo para el foco primario (F/3), con un campo útil mínimo de un grado, y también con la limitante de que sus componentes tuvieron sólamente supérficies esféricas. Ambos diseños de los sis-temas correctores de campo se llevaron a cabo, en gran medida, como parte de un proyecto de colaboración e intercambio en el área de diseño y evaluación de sistemas ópticos.

  9. An electronic register for vital registration in a rural village with no electricity in Malawi.

    PubMed

    Gadabu, O J; Manjomo, R C; Mwakilama, S G; Douglas, G P; Harries, A D; Moyo, C; Makonokaya, L D; Kang'oma, S; Chitedze, P; Chinsinga, F B

    2014-09-21

    Contexte: Village de Chalasa, autorité traditionnelle de Mtema, district de Lilongwe, Malawi.Objectifs : Rapport sur le déploiement d'un registre électronique dans un village rural sans électricité. Les objectifs spécifiques consistaient à documenter 1) les défis de l'installation de ce registre électronique villageois (EVR), 2) la démographie des habitants du village, notamment en termes de naissances et décès pendant trois trimestres, et 3) le coût de l'installation.Schéma: Etude descriptive.Résultats: Les défis principaux ont été la lente adoption de l'EVR par le chef de village, l'absence de cartes de santé des habitants du village, les doubles comptages de certains habitants et les difficultés de connexion. Ces défis ont cependant été surmontés. En termes de données, sur 790 habitants dont 379 (48%) étaient des hommes, 417 (53%) avaient <15 ans et 29 (3.6%) avaient ⩾65 ans. D'avril à décembre 2013, il y a eu 18 naissances et 5 décès. Le coût de l'installation et de la maintenance du registre pendant 12 mois s'est élevé à 6210$US.Conclusion: Un EVR a été installé avec succès dans le village de Chalasa, dans le Malawi rural et il fournit maintenant des données sur la population du village ainsi que sur les naissances et les décès survenant chaque trimestre. Ceci constitue la première étape vers un système d'enregistrement d'état-civil villageois dans l'Afrique rurale.

  10. Identificação de variáveis cataclísmicas eruptivas na direção do bojo galáctico e Nuvens de Magalhães usando dados do OGLE

    NASA Astrophysics Data System (ADS)

    Cieslinski, D.; Diaz, M. P.; Mennickent, R.; Pietrzyski, G.

    2003-08-01

    Na década de 90 iniciaram-se vários programas para a pesquisa de matéria escura na Galáxia usando o efeito de microlentes gravitacionais. Entre os projetos mais bem conhecidos podemos mencionar o OGLE (Optical Gravitational Lensing Experiment) e o MACHO (MAssive Compact Halo Objects). A estratégia usada por eles consiste em fazer fotometria de banda larga (normalmente B, R e I) de um grande número de estrelas (dezenas de milhões) tão freqüentemente quanto possí vel e por longos perí odos de tempo (anos). Uma tal sistemática de observação, além de descobrir inúmeras lentes gravitacionais, é também muito apropriada para a descoberta de estrelas variáveis. De fato, inúmeras novas variáveis de vários tipos foram descobertas como subproduto. Exemplos podem ser encontrados nos endereços http://bulge.princeton.edu/~ogle/ e http://wwwmacho.mcmaster.ca/. As variáveis cataclí smicas eruptivas (novas clássicas, novas recorrentes e novas anãs) são objetos que apresentam variabilidade de grande amplitude com escalas de tempo de dias a centenas de dias e, por esta razão, devem ter sido detectadas em grande número nestes "surveys". Para testar esta possibilidade nós procuramos nos dados do OGLE por tais sistemas e o presente trabalho mostra os resultados desta pesquisa. Os objetos foram selecionados entre as variáveis detectadas usando a amplitude de variação de brilho como critério principal. Este critério forneceu 13756 objetos, sendo 2169 na direção da Grande Nuvem de Magalhães, 1162 na direção da Pequena Nuvem de Magalhães e o restante na direção do Bojo Galáctico. A análise foi feita inspecionando-se visualmente cada curva de luz por erupções com as características acima mencionadas. Os resultados obtidos podem ser sumarizados como: descoberta de duas novas clássicas e 33 novas anãs. Além disso, pode-se mencionar a identificação de candidatas a outros tipos de variáveis como: estrelas simbióticas, RV Tauri, R Coronae

  11. Mapping Self-Organized Criticality onto Criticality

    NASA Astrophysics Data System (ADS)

    Sornette, Didier; Johansen, Anders; Dornic, Ivan

    1995-03-01

    We present a general conceptual framework for self-organized criticality (SOC), based on the recognition that it is nothing but the expression, “unfolded" in a suitable parameter space, of an underlying unstable dynamical critical point. More precisely, SOC is shown to result from the tunning of the order parameter to a vanishingly small, but positive value, thus ensuring that the corresponding control parameter lies exactly at its critical value for the underlying transition. This clarifies the role and nature of the very slow driving rate common to all systems exhibiting SOC. This mechanism is shown to apply to models of sandpiles, earthquakes, depinning, fractal growth and forest fires, which have been proposed as examples of SOC. Nous proposons une stratégie générale pour identifier le mécanisme responsable des phénomènes critiques auto-organisés, basée, sur l'idée qu'ils sont simplement la traduction, dans un espace de paramètres choisis, d'un point critique dynamique instable standard. La criticalité auto-organisée résulte du contrôle du paramètre d'ordre ajusté à une valeur positive tendant vers zéro, ce qui assure automatiquement que le paramètre de contrôle correspondant se cale exactement sur sa valeur critique de la transition de critique sous-jacente. Ce résultat explique le rôle particulier joué par le forçage infiniment lent qui est un caractère commun à tous les systèmes critiques auto-organisés. Nous appliquons ces idées aux modèles de tas de sable, aux modèles de tremblements de terre, de feux de forêts, aux transitions de décrochage et aux modèles de croissance fractale, qui ont été proposés comme autant d'exemples caractéristiques de la criticalité auto-organisée.

  12. Development of a Set of Nomograms to Predict Acute Lower Gastrointestinal Toxicity for Prostate Cancer 3D-CRT

    SciTech Connect

    Valdagni, Riccardo; Rancati, Tiziana Fiorino, Claudio; Fellin, Gianni; Magli, Alessandro; Baccolini, Michela; Bianchi, Carla; Cagna, Emanuela; Greco, Carlo; Mauro, Flora A.; Monti, Angelo F.; Munoz, Fernando; Stasi, Michele; Franzone, Paola; Vavassori, Vittorio

    2008-07-15

    Purpose: To predict acute Radiation Therapy Oncology Group (RTOG)/European Organization for Research and Treatment of Cancer (EORTC) and Subjective Objective Signs Management and Analysis/Late Effect of Normal Tissue (SOMA/LENT) toxicities of the lower gastrointestinal (LGI) syndrome in patients with prostate cancer undergoing three-dimensional conformal radiotherapy using a tool (nomogram) that takes into account clinical and dosimetric variables that proved to be significant in the Italian Association for Radiation Oncology (AIRO) Group on Prostate Cancer (AIROPROS) 0102 trial. Methods and Materials: Acute rectal toxicity was scored in 1,132 patients by using both the RTOG/EORTC scoring system and a 10-item self-assessed questionnaire. Correlation between clinical variables/dose-volume histogram constraints and rectal toxicity was investigated by means of multivariate logistic analyses. Multivariate logistic analyses results were used to create nomograms predicting the symptoms of acute LGI syndrome. Results: Mean rectal dose was a strong predictor of Grade 2-3 RTOG/EORTC acute LGI toxicity (p 0.0004; odds ratio (OR) = 1.035), together with hemorrhoids (p = 0.02; OR 1.51), use of anticoagulants/antiaggregants (p = 0.02; OR = 0.63), and androgen deprivation (AD) (p = 0.04; OR = 0.65). Diabetes (p = 0.34; OR 1.28) and pelvic node irradiation (p = 0.11; OR = 1.56) were significant variables to adjust toxicity prediction. Bleeding was related to hemorrhoids (p = 0.02; OR = 173), AD (p = 0.17; OR = 0.67), and mean rectal dose (p 0.009; OR = 1.024). Stool frequency was related to seminal vesicle irradiation (p = 0.07; OR = 6.46), AD administered for more than 3 months (p = 0.002; OR = 0.32), and the percent volume of rectum receiving more than 60 Gy (V60Gy) V60 (p = 0.02; OR = 1.02). Severe fecal incontinence depended on seminal vesicle irradiation (p = 0.14; OR = 4.5) and V70 (p = 0.033; OR 1.029). Conclusions: To the best of our knowledge, this work presents the

  13. MEETING VENUS. A Collection of Papers presented at the Venus Transit Conference Tromsoe 2012

    NASA Astrophysics Data System (ADS)

    Sterken, Christiaan; Aspaas, Per Pippin

    2013-05-01

    On 2-3 June 2012, the University of Tromsoe hosted a conference about the cultural and scientific history of the transits of Venus. The conference took place in Tromsoe for two very specific reasons. First and foremost, the last transit of Venus of this century lent itself to be observed on the disc of the Midnight Sun in this part of Europe during the night of 5 to 6 June 2012. Second, several Venus transit expeditions in this region were central in the global enterprise of measuring the scale of the solar system in the eighteenth century. The site of the conference was the Nordnorsk Vitensenter (Science Centre of Northern Norway), which is located at the campus of the University of Tromsoe. After the conference, participants were invited to either stay in Tromsoe until the midnight of 5-6 June, or take part in a Venus transit voyage in Finnmark, during which the historical sites Vardoe, Hammerfest, and the North Cape were to be visited. The post-conference program culminated with the participants observing the transit of Venus in or near Tromsoe, Vardoe and even from a plane near Alta. These Proceedings contain a selection of the lectures delivered on 2-3 June 2012, and also a narrative description of the transit viewing from Tromsoe, Vardoe and Alta. The title of the book, Meeting Venus, refers the title of a play by the Hungarian film director, screenwriter and opera director Istvan Szabo (1938-). The autobiographical movie Meeting Venus (1991) directed by him is based on his experience directing Tannhauser at the Paris Opera in 1984. The movie brings the story of an imaginary international opera company that encounters a never ending series of difficulties and pitfalls that symbolise the challenges of any multicultural and international endeavour. As is evident from the many papers presented in this book, Meeting Venus not only contains the epic tales of the transits of the seventeenth, eighteenth and nineteenth centuries, it also covers the conference

  14. Meeting Venus

    NASA Astrophysics Data System (ADS)

    Sterken, Christiaan; Aspaas, Per Pippin

    2013-06-01

    On 2-3 June 2012, the University of Tromsoe hosted a conference about the cultural and scientific history of the transits of Venus. The conference took place in Tromsoe for two very specific reasons. First and foremost, the last transit of Venus of this century lent itself to be observed on the disc of the Midnight Sun in this part of Europe during the night of 5 to 6 June 2012. Second, several Venus transit expeditions in this region were central in the global enterprise of measuring the scale of the solar system in the eighteenth century. The site of the conference was the Nordnorsk Vitensenter (Science Centre of Northern Norway), which is located at the campus of the University of Tromsoe. After the conference, participants were invited to either stay in Tromsoe until the midnight of 5-6 June, or take part in a Venus transit voyage in Finnmark, during which the historical sites Vardoe, Hammerfest, and the North Cape were to be visited. The post-conference program culminated with the participants observing the transit of Venus in or near Tromsoe, Vardoe and even from a plane near Alta. These Proceedings contain a selection of the lectures delivered on 2-3 June 2012, and also a narrative description of the transit viewing from Tromsoe, Vardoe and Alta. The title of the book, Meeting Venus, refers the title of a play by the Hungarian film director, screenwriter and opera director Istvan Szabo (1938-). The autobiographical movie Meeting Venus (1991) directed by him is based on his experience directing Tannhauser at the Paris Opera in 1984. The movie brings the story of an imaginary international opera company that encounters a never ending series of difficulties and pitfalls that symbolise the challenges of any multicultural and international endeavour. As is evident from the many papers presented in this book, Meeting Venus not only contains the epic tales of the transits of the seventeenth, eighteenth and nineteenth centuries, it also covers the conference

  15. Formation and Evolution of Circumbinary Planets, and the Apparent Lack of CPBs Around Short-Period Binaries

    NASA Astrophysics Data System (ADS)

    Haghighipour, Nader

    2015-12-01

    The success of the Kepler space telescope in detecting planets in circumbinary orbits strongly suggests that planet formation around binary stars is robust and planets of a variety of sizes and orbital configurations may exist in such complex environments. Accurate modeling of Kepler data has also indicated that some of these planets orbit their central binaries in close proximity to the boundary of orbital stability. This finding, combined with the unsuccessful attempts in forming circumbinary planets (CBPs) close to the orbital stability limit has lent strong support to the idea that almost all currently known CBPs have formed at large distances and undergone substantial radial migration. A survey of the currently known CBPs further indicates that these planets are mainly Neptune-mass and there seems to be a lack of planets of Jupiter-mass or larger in P-type orbits. Furthermore, an examination of the observational data obtained by the Kepler telescope seems to suggest an absence of CBPs around short-period binaries. Finally, recent detections of episodic transits in the two newly discovered circumbinary systems, Kepler 413b and Kepler 453b, as well as the discovery of Kepler non-transiting CBPs, (please see the abstract by Fabrycky et al) have indicated that in general, the orbits of planets and their host binaries are not co-planar. We present a new model for the formation and evolution of CBPs in which the migration of CBPs has been studied for low and high eccentricity binaries, and for different values of binary period. Results of our extensive hydrodynamical simulations show that planet-disk interaction in low-eccentricity binaries can account for the migration of CBPs and the proximity of their final orbits to the boundary of stability. In eccentric binaries, the situation is, however, more complex and in order to explain the final orbital architecture of the system, other factors such as planet-planet interaction have to be taken into account. We show

  16. Some Observations on Naso-pharyngeal Epidemics in Public Schools.

    PubMed

    Glover, J A

    1928-07-01

    Over 80 per cent. of school sickness, whether judged by the number of cases or by the time lost, is transmitted by "droplet" infection.The alleged increase in sickness in public schools is partly apparent, due to increased attention to minor febricula and partly real, due (1) to increased influenza prevalence, the aftermath of the great epidemic of 1918, and (2) to the increased demand for public school education leading to pressure upon accommodation, and especially to overcrowding in dormitories.The bulk of the droplet infections are accounted for by (1) influenza; (2) feverish cold, chill, or P.U.O.; (3) tonsillitis; regular infectious diseases make a comparatively small showing. The incidence and bacteriological findings and the variations in the incidence of pneumonia and otitis media are discussed. Are these complications really secondary epidemics? Tonsillitis, bacteriological findings, milk.Prophylaxis.-Efficacy of vaccines uncertain. Some evidence that they may diminish the onset of complications. If given vaccines should be administered before the danger period, i.e., not later than November.Intensive prophylaxia other than vaccines during the first half of the Lent term would probably amply repay any trouble. It should include:-(a) Special efforts to prevent boys returning to school after the Christmas holidays infected with influenza or febricula.(b) Temperature taking for three weeks.(c) Immediate isolation of all pyrexias and catarrhs.(d) No work before breakfast for at least the first six weeks of the term.(e) All hot baths and showers taken during the day or after games to be followed by cold showers.(f) Prevention of chill in watching games, etc.(g) Increased provision for drying clothes, uniforms and boots.Infection mainly takes place in sleeping quarters, and proper spacing out of beds and thorough "cross" ventilation in dormitories is of paramount importance; instances of cross infection due to proximity of beds; illustrated by bed charts and

  17. Etat nutritionnel des enfants âgés de 6 à 59 mois infectés par le VIH mais non traités aux ARV à Lubumbashi

    PubMed Central

    Mwadianvita, Costa Kazadi; Kanyenze, Faustin Ngoy; Wembonyama, Cecile Watu; Mutomb, Florence Mujing A; Mupoya, Kalombo; Nkoy, Albert Mwembo–Tambwe A; Mwenze, Prosper Kalenga

    2014-01-01

    Introduction L'infection par le VIH provoque et/ou aggrave les déficits nutritionnels de l'enfant. Ce travail avait pour objectif d'analyser l’état nutritionnel des enfants infectés par le VIH à Lubumbashi. Méthodes Une étude transversale portant sur 83 enfants âgés de 6 à 60 mois s'est déroulée de mai 2010 à mai 2011 dans trois(3) centres de prise en charge des Personnes Vivant avec le VIH(PVV), notamment le Centre d'Excellence(CE) de l'hôpital Sendwe, le Centre Amo-Congo de la Kenya et le Centre de Référence de la Kenya. Les statistiques descriptives usuelles ont été utilisées. Résultats La prévalence de la malnutrition globale était de 60,2% (n = 50) dont 8,4% de malnutrition sévère. Le poids moyen était de 11,6±4,1 kg avec un minimum de 5 kg et un maximum de 22 kg. Le taux d'hémoglobine moyen était d'environ 9,8± 2,0 g/dl avec une prévalence globale de l'anémie (hémoglobine < 11g/dl) à 69,9%. L’émaciation concernait 20,5% des enfants et 8,4% avaient un retard de croissance. Le retard de croissance (p = 0,007), l'insuffisance pondérale (p = 0,002) et l’émaciation (p = 0,046) étaient associés de façon significative à l’état avancé de l'infection à VIH. La survenue de l'anémie n’était pas associée au déficit nutritionnel (p = 0,6). Conclusion Ces résultats révèlent que l'infection à VIH modifie l’état nutritionnel des enfants à Lubumbashi avec 60,2% de malnutrition globale et 8,4% de retard de croissance. Les enfants au stade avancé de l'infection à VIH en sont plus affectés. PMID:25574336

  18. "out of The Cold": On Late Neanderthal Population Dynamics In Central Europe

    NASA Astrophysics Data System (ADS)

    Jöris, O.

    During the last several years, analyses of fossil Neanderthal DNA have shown not only the degree to which the genetic fingerprints of Neanderthals differ from those of anatomically modern humans, but have also lent credibility to the hotly debated "Out- of-Africa" hypothesis. Perhaps more important than the observed genetic differences is the fact that Neanderthals - according to their reconstructed DNA sequences - were genetically highly homogeneous, indicating rapid population growth that may have followed a demographic 'bottleneck' during the first cold maximum (CM-1 = second part of OIS 4) of the last glacial, some 60 to 70 ka ago. Central European Middle Palaeolithic sites characterised by broad spectra of bifacially-worked tools, namely different forms of backed knives ("Keilmesser") com- monly attributed to Neanderthals, fall within the age-range 85 and 45 ka calBP and thus both pre- and post-date the proposed 'bottleneck' that occurred during CM-1. Di- rectly comparable sites dating within this critical period are lacking. Based on strati- graphic, palaeoenvironmental, and radiometric evidence, a series of sites can tenta- tively be age-calibrated with the high-resolution GISP2 Greenland ice core record of last glacial climate change. With the aid of improved chronological frameworks and additional palaeoenvironmen- tal information (e.g. glacier mass balance models), we have developed a three-step model with which to investigate this period. We begin with (1) pre-CM-1 populations in Central and northern Central Europe which (2) were forced into southern Euro- pean refugia (i.e. SW France and the Pannonian Basins) by the rapid expansion of the northern hemispheric ice-cover at the beginning of CM-1 (a process that could be named 'preglacial dislocation'). Finally, some 10 ka later, their descendants may have re-occupied the southern part of Central Europe during the climatic amelioration (OIS 3) following CM-1. Changes in lithic technology, as expressed in

  19. Étude de surface d'une poudre d'alliage d'aluminium

    NASA Astrophysics Data System (ADS)

    Trochim, D.; Bois, N.; Chermant, J. L.

    1997-04-01

    écapage superficiel des échantillons a permis une analyse en profondeur du matériau ; le rapport \\{I_MgO/(I_AlO + I_Al)\\} (I désigne l'intensité intégrée de raies photoélectronique) tend de façon asymptotique vers une valeur constante lorsque l'on progresse vers le cceur de l'échantillon. Ce rapport est égal à 5 % pour le matériau brut et celui chauffé à 410 °C. Qualitativement, on a mis en évidence l'existence d'une structure amorphe de l'alumine sans qu'il y ait une transformation sous la forme cristallisée γ{-}Al_2O_3 après chauffage du matériau. De ce fait, le phénomène physique inhérent à la présence croissante de MgO serait la sublimation lente du magnésium.

  20. Kuwait.

    PubMed

    1988-03-01

    ,000 barrels per day. Other industrial products include ammonia, chemical fertilizers, fishing and water desalinization (215 million gallons a day). Kuwait imports machinery, manufactured goods, and food. Nevertheless exports exceed imports by $2 billion, and the Kuwaiti dinar is a strong currency (1 KD=US$3.57). About $75 billion is kept in 2 reserve funds: the Fund for Future Generations and the General Reserve Fund. In addition to domestic expenditures and imports, Kuwait has extended $5 billion worth of loans to developing countries, made through the Kuwait Fund for Arab Economic Development. Kuwait has been engaged in continuing border disputes with Iraq since 1961, but the most immediate threat to Kuwait has been the Iran-Iraq war. Kuwait lent Iraq $6 billion, in retaliation for which Iran bombed a Kuwaiti oil depot, and Shi'a Muslim terrorists bombed the French and US embassies and hijacked a Kuwaiti airliner in 1984. Iran also attacked Kuwaiti tankers. In 1987 the US reflagged 11 Kuwaiti tankers to protect them from Iranian attacks. Kuwait has been modernizing its own military forces as well as purchasing sophisticated weapons from the UK, the US, France, and the USSR. In 1981 Kuwait, Saudi Arabia, Bahrain, Qatar, the United Arab Emirates and Oman formed the Gulf Cooperation Council (GCC) for mutual defense, and in 1987 Kuwait was elected chairman of the Organization of the Islamic Conference (OIC). Kuwait has diplomatic relations with the USSR and the People's Republic of China, as well as with the US, which has supplied Kuwait with $1.5 billion of sophisticated weaponry from foreign military sales (FMC). The US is Kuwait's largest supplier (after Japan), and Kuwait is the 5th largest market in the Middle East for US goods, despite the disincentives brought about by the Arab boycott of Israel.

  1. Spin glasses - A transition in plain ordinary space

    NASA Astrophysics Data System (ADS)

    Souletie, J.

    We are living a fascinating moment where theorists, faced to ample experimental and (more recent) simulation evidence seem to have little choice other than to accept that the transition which they described, actually occurs in our ordinary space at 3 d. We review here some of the experimental arguments, based on critical measurements performed at equilibrium in the high temperature phase, and we stress the similarities and the differences with superparamagnetism and with an ordinary phase transition. By contrast, the slow relaxations which are observed in the low temperature phase below Tc are interpreted in terms of activation over finite energy barriers and would suggest little more than ordinary superparamagnetism. Some features of the Fulcher law which describes the edge between the equilibrium and the non equilibrium regimes, would allow to conciliate both points of view : it is the critical divergence of the barrier heights, on approaching Tc from above, which is responsible for the fact that the system appears blocked at a temperature Tg(t) slightly larger than Tc for all experiments performed in a finite time t. Nous vivons un moment fascinant ou les théoriciens, confrontés aux résultats de l'expérience et (plus récemment) de la simulation semblent n'avoir guère d'autre choix que d'accepter que la transition qu'ils avaient décrite existe bien dans notre espace à trois dimensions. Nous discutons ici quelques-uns des arguments expérimentaux basés sur l'étude de l'approche critique à Tc dans l'état paramagnétique et nous soulignons les similitudes et les différences avec le superparamagnétisme et avec une transition de phase ordinaire. Quant aux relaxations lentes qui sont observxA9es dans la phase de basse température au-dessous de Tc, leur interprétation en termes d'activation thermique suggérerait des barrières finies et du superparamagnétisme. Quelques aspects de la loi de Fulcher qui décrit bien le comportement de la temp

  2. Rectal wall sparing by dosimetric effect of rectal balloon used during intensity-modulated radiation therapy (IMRT) for prostate cancer.

    PubMed

    Teh, Bin S; Dong, Lei; McGary, John E; Mai, Wei-Yuan; Grant, Walter; Butler, E Brian

    2005-01-01

    The use of an air-filled rectal balloon has been shown to decrease prostate motion during prostate radiotherapy. However, the perturbation of radiation dose near the air-tissue interfaces has raised clinical concerns of underdosing the prostate gland. The aim of this study was to investigate the dosimetric effects of an air-filled rectal balloon on the rectal wall/mucosa and prostate gland. Clinical rectal toxicity and dose-volume histogram (DVH) were also assessed to evaluate for any correlation. A film phantom was constructed to simulate the 4-cm diameter air cavity created by a rectal balloon. Kodak XV2 films were utilized to measure and compare dose distribution with and without air cavity. To study the effect in a typical clinical situation, the phantom was computed tomography (CT) scanned on a Siemens DR CT scanner for intensity-modulated radiation therapy (IMRT) treatment planning. A target object was drawn on the phantom CT images to simulate the treatment of prostate cancer. Because patients were treated in prone position, the air cavity was situated superiorly to the target. The treatment used a serial tomotherapy technique with the Multivane Intensity Modulating Collimator (MIMiC) in arc treatment mode. Rectal toxicity was assessed in 116 patients treated with IMRT to a mean dose of 76 Gy over 35 fractions (2.17-Gy fraction size). They were treated in the prone position, immobilized using a Vac-Loktrade mark bag and carrier-box system. Rectal balloon inflated with 100 cc of air was used for prostate gland immobilization during daily treatment. Rectal toxicity was assessed using modifications of the Radiation Therapy Oncology Group (RTOG) and late effects Normal Tissue Task Force (LENT) scales systems. DVH of the rectum was also evaluated. From film dosimetry, there was a dose reduction at the distal air-tissue interface as much as 60% compared with the same geometry without the air cavity for 15-MV photon beam and 2x2-cm field size. The dose beyond the

  3. Lignes directrices canadiennes sur l’utilisation sécuritaire et efficace des opioïdes pour la douleur chronique non cancéreuse

    PubMed Central

    Kahan, Meldon; Mailis-Gagnon, Angela; Wilson, Lynn; Srivastava, Anita

    2011-01-01

    Résumé Objectif Présenter aux médecins de famille un résumé clinique pratique des lignes directrices canadiennes sur l’utilisation sécuritaire et efficace des opioïdes pour la douleur chronique non cancéreuse, produites par le National Opioid Use Guideline Group. Qualité des données Pour produire les lignes directrices, les chercheurs ont effectué une synthèse critique de la littérature médicale sur l’efficacité et l’innocuité des opioïdes pour la douleur chronique non cancéreuse et ont rédigé une série de recommandations. Un panel de 49 cliniciens experts de toutes les régions du Canada ont passé en revue l’ébauche et ont atteint un consensus sur 24 recommandations. Message principal Il est recommandé de faire un dépistage du risque de dépendance avant de prescrire des opioïdes. On recommande des opioïdes faibles (codéine et tramadol) pour une douleur de légère à modérée qui n’a pas répondu aux traitements de première intention. On peut essayer l’oxycodone, l’hydromorphone et la morphine chez les patients qui n’ont pas eu de soulagement avec des opioïdes plus faibles. Une faible dose initiale et une lente hausse du titrage sont recommandées, ainsi qu’une étroite surveillance du patient qu’on a d’abord renseigné. Les médecins doivent surveiller l’apparition de complications comme l’apnée du sommeil. La dose optimale est celle qui améliore le fonctionnement ou atténue les cotes d’évaluation de la douleur d’au moins 30 %. Pour la grande majorité des patients, la dose optimale sera bien en deçà de l’équivalent de 200 mg de morphine par jour. On recommande le sevrage progressif pour les patients qui n’ont pas répondu à un essai d’opioïdes adéquat. Conclusion Les opioïdes jouent un rôle important dans la prise en charge de la douleur chronique non cancéreuse, mais il faut en prescrire avec prudence pour limiter les dommages potentiels. Les nouvelles lignes directrices

  4. Surfactant Saturation of Drops in Microgravity by Terrestrial Simulation

    NASA Astrophysics Data System (ADS)

    Viviani, Antonio

    It is well known that diffusion plays an appreciable role in mass transfer only in the case of weak gravitational convection. However, even under such conditions the use of a surfactant as a dif-fusing substance essentially complicates the mass transfer processes. The appearance of gas or liquid inclusions in the surfactant solution causes the development of solutocapillary motion on their surface, which may become a generator of the large-scale flows in the surrounding liquid, especially in microgravity conditions. The paper presents the results of terrestrial simulation of such flows during saturation of the drop of weakly soluble fluid by a surfactant from its water solution forming a thin ( 1 ) horizontal layer. In our experiments, we used chlorobenzene and water as the basic fluids of the drop and the surrounding medium, respectively, and isopropyl alcohol -as a surfactant. The initial concentration 0 of the alcohol in the solution ranged from 5 to 50%. This lent specific feature to the saturation process, manifesting itself in the fact that at concentration higher than 25% a mutual dissolution of water and chlorobenzene began to increase. Visualization of flow structures and concentration fields showed that in laboratory conditions even at maximum suppression of the gravitational convection the saturation of the surfactant is a rather complicated process specified by the initial surfactant concentration in the solution and by the degree of the solution homogeneity. In the case of initially homoge-neous solution, a complicated character of mass transfer between the drop and the surrounding medium is evidently due to the small values of surfactant diffusion coefficients in basic flu-ids. Penetration of the surfactant into the drop leads to the formation of local inhomigeneities of the solution density at both sides of the interface and to the development of a slow three-dimensional flow of gravitational nature. An increase in the concentration gives rise to a

  5. Large scale crystallization of protein pharmaceuticals in microgravity via temperature change

    NASA Technical Reports Server (NTRS)

    Long, Marianna M.

    1992-01-01

    The major objective of this research effort is the temperature driven growth of protein crystals in large batches in the microgravity environment of space. Pharmaceutical houses are developing protein products for patient care, for example, human insulin, human growth hormone, interferons, and tissue plasminogen activator or TPA, the clot buster for heart attack victims. Except for insulin, these are very high value products; they are extremely potent in small quantities and have a great value per gram of material. It is feasible that microgravity crystallization can be a cost recoverable, economically sound final processing step in their manufacture. Large scale protein crystal growth in microgravity has significant advantages from the basic science and the applied science standpoints. Crystal growth can proceed unhindered due to lack of surface effects. Dynamic control is possible and relatively easy. The method has the potential to yield large quantities of pure crystalline product. Crystallization is a time honored procedure for purifying organic materials and microgravity crystallization could be the final step to remove trace impurities from high value protein pharmaceuticals. In addition, microgravity grown crystals could be the final formulation for those medicines that need to be administered in a timed release fashion. Long lasting insulin, insulin lente, is such a product. Also crystalline protein pharmaceuticals are more stable for long-term storage. Temperature, as the initiation step, has certain advantages. Again, dynamic control of the crystallization process is possible and easy. A temperature step is non-invasive and is the most subtle way to control protein solubility and therefore crystallization. Seeding is not necessary. Changes in protein and precipitant concentrations and pH are not necessary. Finally, this method represents a new way to crystallize proteins in space that takes advantage of the unique microgravity environment. The results

  6. Révision systématique des effets de la fréquence des repas en famille sur les résultats psychosociaux chez les jeunes

    PubMed Central

    Harrison, Megan E.; Norris, Mark L.; Obeid, Nicole; Fu, Maeghan; Weinstangel, Hannah; Sampson, Margaret

    2015-01-01

    tudes révèlent des différences considérables dans les résultats chez les enfants et adolescents masculins et féminins, les sujets féminins ayant des résultats plus positifs. Conclusion Cette révision systématique vient confirmer davantage qu’il convient de préconiser de fréquents repas en famille. Tous les professionnels de la santé devraient renseigner les familles concernant les bienfaits de prendre régulièrement ensemble des repas.

  7. Etude des systèmes protoplanétaires

    NASA Astrophysics Data System (ADS)

    Augereau, Jean-Charles

    2000-11-01

    Les disques de poussières et de gaz autour des étoiles rejoignant la Séquence Principale sont les sites de formation des planètes extra-solaires dont l'existence s'est vu confirmée récemment. Cette thèse aborde l'étude de la poussière des environnements circumstellaires. Elle associe des observations spatiales à haute résolution angulaire, la modélisation des propriétés physico-chimiques des poussières et leur comportement optique, la modélisation des disques optiquement fins et la dynamique des planétésimaux à l'origine des grains observés autour des étoiles âgées. Les images obtenues avec le Télescope Spatial Hubble révèlent deux nouveaux disques circumstellaires autour des étoiles HD 141569 et HD 100546, parfois classées dans la catégorie des étoiles de Herbig. Bien que les systèmes présentent des âges proches (~10 millions d'années), les morphologies très différentes des disques mettent en évidence la difficulté pour élaborer un scénario unique d'évolution des systèmes protoplanétaires. L'anneau fin de poussières autour de HR 4796A, une étoile d'âge similaire aux précédentes, est marginalement résolu depuis le sol. La modélisation complète de ce disque permet de reproduire l'ensemble des observations disponibles. Ces résultats impliquent la présence de planétésimaux, à un âge aussi peu avancé, pour repeupler le disque en poussières poreuses et essentiellement amorphes qui sont soufflées par la pression de radiation. Une modélisation dynamique du prototypique disque autour de β Pictoris est proposée. Associée à une description réaliste du comportement optique des grains, cette approche reproduit les caractéristiques générales du disque ainsi que des asymétries plus fines en supposant la présence d'une planète dans un disque de planétésimaux et en tenant compte des effets différentiels de la pression de radiation sur les grains. Enfin, le modèle de disques que j'ai développé est exploit

  8. Inhomogeneites dans le Vent des Etoiles Wolf-Rayet

    NASA Astrophysics Data System (ADS)

    Robert, Carmelle

    1992-01-01

    Des mesures spectroscopiques effectuees avec un haut rapport signal sur bruit et une bonne resolution ont demontre l'existence de regions perturbees en mouvement dans le vent d'etoiles Wolf-Rayet (WR). L'echantillon d'objets etudies ici comprend 9 etoiles WR couvrant differents sous-types WN et WC. De nombreuses petites structures variables superposees au profil des raies d'emission formees dans le vent stellaire signalent la presence des perturbations. L'etude des variations globales des raies et l'examen des micro-structures individuelles ont permis de decrire plusieurs caracteristiques des perturbations. Entre autres, on observe des correlations significatives entre le niveau de variabilite des raies et certains parametres des etoiles qui confirment que le phenomene de variabilite est intrinseque au vent stellaire. En comparant les changements des vitesses radiales et des largeurs equivalentes des differentes raies d'une meme etoile, on conclut que les regions perturbees ont une etendue finie par rapport a l'enveloppe des etoiles. On peut facilement suivre les structures individuelles sur une periode de temps couvrant ~eq8 heures (et peut etre meme 24 heures) avant qu'elles ne disparaissent. Durant ce temps les structures se deplacent en s'eloignant du centre de la raie. A partir des differents comportements notes lors de l'analyse des variations globales et lors de l'examen des structures individuelles, on propose de representer les perturbations par un modele d'inhomogeneites discretes en expansion dans le vent. On suppose simplement que les inhomogeneites emettent comme le vent global (et absorbent aussi si le vent global montre un profil P Cyg). La superposition du graphique de l'acceleration radiale moyenne des inhomogeneites de WR140 en fonction de leur vitesse radiale et du modele theorique d'inhomogeneites qui suivent la loi generale de vitesse donne un taux d'acceleration lent, avec beta >= 3 pour les inhomogeneites de cette etoile. On obtient, entre

  9. The effect of systematic vocabulary instruction on the science achievement of fifth-grade students

    NASA Astrophysics Data System (ADS)

    Rosebrock, Melanie M.

    2007-12-01

    grade science teachers and approximately 700 fifth grade students in a medium-sized (approximately 16,000 students) school district in southeast Texas participated in the study. The model of systematic vocabulary instruction applied in this study combined best practice from the fields of reading and science instruction. While the results indicated a statistically significant F-ratio (F = 13.22, p < .001) substantiating the directional research hypothesis (in support of systematic vocabulary instruction in science), the effect size (d = +0.13) did not imply educational significance. Based on this somewhat unsettled outcome, the usefulness of this assemblage of strategies may yet be proven as a valuable instructional model, or it may simply be abandoned as a step in the evolutionary progression toward a genome for instructional effectiveness in elementary science. Understanding the extent to which best practice vocabulary instruction from the field of literacy education may be balanced with inquiry instruction from the field of science education may begin to improve the deficient state of science education. Most especially at the elementary level, where teachers are more likely to be familiar with the pedagogy of reading than any other content area, a familiar approach lent different content may render increased effectiveness in teaching elementary science students.

  10. La fragilité

    PubMed Central

    Lee, Linda; Heckman, George; Molnar, Frank J.

    2015-01-01

    , on a accordé peu d’attention au concept de la fragilité en médecine familiale. La fragilité peut aisément passer inaperçue parce que ses manifestations sont souvent subtiles, de progression lente et, par conséquent, elle peut être méprise pour un vieillissement normal. La formation des médecins a insisté sur des maladies médicales spécifiques plutôt que sur la vulnérabilité globale. Pour les médecins en soins primaires, la reconnaissance de la fragilité peut les aider à offrir un counseling approprié aux patients et aux membres de leur famille au sujet des risques des interventions médicales.

  11. Le dermatofibrosarcome de Darier et Ferrand, une tumeur cutanée particulière: à propos de 32 cas et revue de la littérature

    PubMed Central

    Elamrani, Driss; Droussi, Hatim; Boukind, Samira; Elatiqi, Keltoum; Dlimi, Meriem; Benchamkha, Yassine; Ettalbi, Saloua

    2014-01-01

    Le dermatofibrosarcome (DFS) est une tumeur fibreuse de la peau, de croissance lente, à très haut risque de récidive locale, mais à potentiel métastatique faible. A partir d'une étude rétrospective étalée sur une période de 5 ans (décembre 2008 - décembre 2013), nous avons analysé les caractéristiques épidémiologiques et cliniques, le délai de diagnostic, le type de thérapeutique et le devenir de 32 patients présentant des tumeurs de Darier et Ferrand histologiquement prouvées. Parmi les 32 patients, 10 se sont présentés initialement au service pour une récidive tumorale. Une discrète prédominance masculine a été notée. Les DFS touchent préférentiellement l'adulte jeune. Le délai diagnostique observé est en moyenne de 4 ans. Le tronc est la localisation préférentielle (60%), suivi par les extrémités proximales (30%). Les 32 patients ont été traités par exérèse chirurgicale avec une marge de 5cm en surface, emportant en profondeur une barrière anatomique saine. La couverture de la perte de substance (PDS) a été réalisée après confirmation anatomopathologique du caractère carcinologique de l'exérèse, et a fait appel à différents moyens allant de la greffe cutanée aux lambeaux musculo –cutanés libres. L’évolution a été marquée par la survenue d'une récidive tumorale chez 8 patients (3 cas parmi les tumeurs vues en première intention et 5 cas parmi les tumeurs vues en récidive) et les résultats ont été jugés satisfaisants sur le plan esthétique et fonctionnel. Le DFS de Darier et Ferrand est une tumeur dont le pronostic et le risque évolutif sont principalement liés au délai diagnostic et la qualité de la première exérèse. Le diagnostic tardif, rend difficile la chirurgie d'exérèse et de reconstruction Les possibilités de guérison en cas de chirurgie primaire bien conduite sont significativement supérieures à celles d'une chirurgie de rattrapage. L'amélioration du pronostic passe par

  12. Development 3D model of adaptation of the Azerbaijan coastal zone at the various levels of Caspian Sea

    NASA Astrophysics Data System (ADS)

    Mammadov, Ramiz

    2013-04-01

    The most characteristic feature of the Caspian Sea which difference it on relation other seas is its periodical fluctuating in its level. In many coastal regions of the world the problem of influence of change of a sea level on activities of the human is a problem of the long-term future, but in region of Caspian Sea, especially in its Azerbaijan sector, it is already actual. Also experience accumulated here, can be use at the decision of problems of optimization of wildlife management in conditions of significant change of a sea level as model of potential consequences of warming of a climate. Changeableness of the level of the Caspian sea over many years can be observed better on the basis of natural observations, a systematic basis of which has been put by the academician E. Lents in 1830 year in Baku coastal line. According these data in 1882 the average level has reached its level -25.2 m. the highest point over the observations, i.e. by 1.8 m. higher than today's level. The average level over 1830-1930 was about -25.83 m. In 1960 some stabilization in the level, about 28,4 meters, in 1970 was a sharp drop, in 1977 - sharp drop reached -29.00 rn. The drop over the whole period of observations totaled 3.8 m within diapason -25.2 -29.0 m. In 1978 the level of the sea began to increase and in 1995 its average yearly mark reach -26,62 rn. Intensiveness of the rise of the level ever that period totaled in average about 14 cm per year. As a result of this rise of a sea level about 800 km2 of a coastal zone it has been flooded, the ecological situation has worsened, and there were ecological refugees. The damage to a coastal zone of Azerbaijan was 2 billion USA dollars. Caspian sea also has within-year (seasonal) variability equal 32 sm and sleeve and pileup change of level. Its estimate in Azerbaijan coastal zone is 0.8-1.0 m. In the coastal zone also necessary take into height of the wave which in these coasts can be 3.0 m height. All these means that in the

  13. Structural study of CH4, CO2 and H2O clusters containing from several tens to several thousands of molecules

    NASA Astrophysics Data System (ADS)

    Torchet, G.; Farges, J.; de Feraudy, M. F.; Raoult, B.

    CH4, phase solide unique pour CO2 ou phase cubique métastable pour H2O. Lorsque la taille des agrégats décroît, leurs comportements se révèlent très différents selon les molécules étudiées : les agrégats de CO2 conservent la même structure cristalline, les agrégats de CH4 adoptent la structure icosaédrique multicouche trouvée pour les agrégats de gaz rares, et les agrégats de glace adoptent une structure désordonnée différente des structures amorphes de la glace massive.

  14. Etude des lois de comportement a haute temperature en ``plasticite-fluage'', d'un acier inoxydable austenitique (12 17 SPH)

    NASA Astrophysics Data System (ADS)

    Delobelle, P.; Oytana, C.

    1986-07-01

    De façon à compléter une étude antérieure portant sur le fluage à haute température d'un acier inoxydable austénitique du Type 316 (12-17 SPH) et afin de comprendre les relations de couplage qui existent entre les grandes déformations quasiment indépendantes du temps (plasticité) et les petites déformations souvent trés lentes (viscoplasticité), toujours intimement liées pour cet alliage, nous avons réalisé différents essais à vitesse imposée: traction, traction-compression, torsion-alternée., Durant ces essais nous avons estimé l'ordre de grandeur de la contrainte visqueuse σzz = σv par la méthode de la relaxation inverse. De façon à révéler clairement les effets liés intrinsèquement au temps avons réalisé différentes séquences de vieillissement après écrouissage. Pour intégrer et décrire l'ensemble des phénonèmes observés, nous proposons un modèle unifié dont les caractéristiques principales sont les suivantes: (i) Unicité de l'équation d'état viscoplastique: ɛ = f¦σ - α¦, avec f fortement non linéaire, ce qui permet de traduire les effets dépendant et quasiment indépendant du temps. (ii) La distinction entre grande et petite déformations s'effectue à l'aide d'un critére de charge, active ou passive, portant sur la variable α. (iii) Dans l'état de microviscoplasticé, on a α = α1, tel que α 1 présente un fort coefficient d'écrouissage h0. Dans le cas inverse, on décompose α selon α = α1 = α2 + Y et tel que les coefficients d'écrouissage vérifient: H1 + Hα2 ≪ hα1 . (iv) L'effet du temps, permettant d'atteindre l'écoulement stationnaire, indifférent à l'état du système, est pris en compte par les termes de restauration dans les lois d'évolution des variables internes. On présente quelques simulations, réalisées avec le modèle développé, pour différents types de sollicitations.

  15. Basic elements of an international terrestrial reply following the detection of a signal from extraterrestrial intelligence

    NASA Astrophysics Data System (ADS)

    Reijnen, G. C. M.

    One of the most tantalizing questions human intelligence has posed itself since the beginnings of time is whether we are alone in the Universe. And if not, where are "the others," and is it possible that these "others" may contact us, with or without our knowledge? Scientific literature abounds with theories pro and con, and if any subject ever lent itself to make-believe it is this one. Connected with the scientific theories on the subject, which are so often misunderstood, popular belief has led to a steady stream of publications which have done nothing if they have not greatly hampered the real issue. In legal circles the subject of possible contacts with extraterrestrial intelligence was first discussed in the literature in the early 1960's when, among others, Andrew Haley wrote, in 1965, about "Space Law and Government." This publication appeared in the midst of the United Nations preparations for what was to become, in 1967, the Outer Space Treaty. Though the idea of an international protocol governing actions after the detection of a signal from extraterrestrial intelligence has never been on the agenda of the United Nations Committee on the Peaceful Uses of Outer Space, space lawyers continue to think and to write about that subject. Recent advances in spaceflight, in particular the Voyager missions to the outer planets of our solar system, give the subject a new impetus. The present paper is intended to dwell upon present scientific thoughts about the likelihood that a signal from extraterrestrial intelligence will be detected in the near future. Although this likelihood appears to be remote, it seems, nevertheless, worthwhile that discussion continues in space legal circles regarding the formulation of an international protocol for activities following the detection of a signal from extraterrestrial intelligence. Since the confirmed detection of a signal from extraterrestrial intelligence could well be of crucial importance for the continuing existence of

  16. Presumably bacterial remains in banded iron formations: beginning of investigations

    NASA Astrophysics Data System (ADS)

    Astafieva, M.

    2014-04-01

    enlargement are occurred under sediment ageing and abiogenic magnetite recrystallization [1]. That is why in nature in case of ancient sediments and metamorphic rocks it is almost impossible to reveal biogenic origin of magnetite [3]. We decided to begin studying problem of banded iron formations origin because of its great interest. Archaean (2.75 GA) banded iron formations of Olenegorsk deposit (Kola Peninsula) were chosen as a model object. Material was kindly lent us by our colleagues from Institute of Precambrian Geology and Geochronology - S. Felitsyn and N. Alfimova. Interesting results were received while bacterial-paleontological studying. Threadlike, coccoidal, dumbbell-like etc. forms presumably of bacterial nature were discovered. The most abundant and diverse forms are those close to coccoidal - the very cocci, oval, dumbbell-like etc. forms. Sizes of the most part of discovered objects about 1 μm. Thread-like forms are met less often and mainly are represented by long thin single threads. The most part of biogenic structures was found in ferruginous interlayers. The whole rock fragments often consist almost completely from such structures, biogenic forms sink into rock matrix, some images show their location inside rock sample. There are no reasons to doubt that these biogenic forms were found in situ. In siliceous interlayers presumably biogenic forms are very rare. There are mainly long thin thread-like forms merged with the rock. As can be seen from the above it is possible to make preliminary conclusion about Archaean of banded iron formations biogenic origin and about microorganism participation in the process of banded iron formations formation. Investigations are continuing.

  17. Hubble refurbished and ready for release

    NASA Astrophysics Data System (ADS)

    1993-12-01

    The deployment of the solar arrays came at the end of the fifth and final spacewalk of the mission. Story Musgrave and Jeff Hoffman spent seven-hours in the cargo bay fitting new electrical systems and installing covers over the telescope's old magnetometers. The first task was the installation of "SADE", a new ESA- supplied Solar Array Drive Electronics box. The box directs the twin solar panels at the Sun. The astronauts then lent a helping hand to lower the masts holding the solar arrays to their deployment position. Flight controllers decided to crank the masts out manually because of minor trouble with the latches. The next job was the installation of the Goddard High Resolution Spectrograph (GHRS) Redundancy Kit, a device that provides an alternate power and data route for the instrument. The ESA supplied solar blankets rolled off their canisters without incident between 4 and 4h35 a.m. CST (11 and 11h35 a.m. CET). An hour later the new SADE system turned the arrays towards the sun. "It is a tribute to the whole team, from the designers to the astronauts, that everything has gone so well", said Derek Eaton, ESA's HST project manager. "I only hope that the array will look so good when the shuttle returns to the telescope in 1997". The telescope's first set of solar arrays flexed in orbit because of the sudden swing in temperature as the telescope moved in and out of sunlight. The movement, known as jitter, affected the telescope's pointing system and disrupted observations at certain times. Special software compensated largely for the problem but this occupied a large amount of computer memory. The design of the new arrays was modified to eliminate the problem. Eaton said he was "101 per cent" confident that jitter from the arrays would no longer affect the work of the telescope. The deployment of the power-generating wings brought the servicing work to a close. If all goes according to plan, the telescope will return to orbital at 1.08 a.m. CST (8.08 a.m. CET

  18. First 3D thermal mapping of an active volcano using an advanced photogrammetric method

    NASA Astrophysics Data System (ADS)

    Antoine, Raphael; Baratoux, David; Lacogne, Julien; Lopez, Teodolina; Fauchard, Cyrille; Bretar, Frédéric; Arab-Sedze, Mélanie; Staudacher, Thomas; Jacquemoud, Stéphane; Pierrot-Deseilligny, Marc

    2014-05-01

    to extract 3D informations from thermal images taken from different positions. This paper presents the first 3D thermal map of an active volcano (Piton de la Fournaise, La Réunion Island) directly generated from 70 thermal images (so-called "stereothermogrammetric" DEM). The data were obtained above Dolomieu caldera by helicopter just before sunrise, during a clear weather in 2008. They were obtained before the eruptive events occurring within the Dolomieu caldera. We used a 28 mm focal FLIR Thermacam PM695 lent by the Piton de la Fournaise Observatory. The thermal images were acquired automatically every 30 seconds with the helicopter flying around the caldera at low altitude (less than 100 m height above the caldera). This survey led to the acquisition of images with a ground pixel size in the range of 1-3 m. A particular attention has been brought to the obtaining of a high overlap percentage (80 percents) for the localization of the maximum tie points on the image. Finally, the acquisition of 70 images allowed the generation of a 3D thermal model of the caldera containing more than 500000 points. i.e. 1 point each 2 m², considering a surface of 106 m² for the Dolomieu caldera. This model is then compared with a DEM recently obtained with the LIDAR method after the eruptive events occurring within Dolomieu. The comparison of these independent methods leads to the validation of the stereothermogrammetric method. It allows the quantification of the thickness of the lava flows within the Dolomieu collapse in 2008 and 2009, i.e. approximately 80 meters, as estimated by previous studies from field observations.

  19. Étude par spectroscopie d'admittance et MEB de la dégradation électrique des couches minces de CuAlS{2} non dopé déposées sous vide

    NASA Astrophysics Data System (ADS)

    Helali, N.; Bouricha, B.; Rezig, B.

    1998-07-01

    dissipation thermique qui peut augmenter notablement leur température (140 °C). Les spectres d'admittance révèlent, vers les basses fréquences, une boucle capacitive reliée à la formation d'une charge d'espace induite par la diffusion du cuivre. Une telle migration développe, sur la surface depuis la cathode, des arborescences de cuivre orientées vers l'anode. L'effet de ces structures sur les propriétés des couches dégradées a été discuté en mettant en cause le phénomène d'électromigration et ses mécanismes associés (whiskers, fracture, “healing", pontage, ...). De même, nous avons noté leur similarité avec des phénomènes fractals tels que l'électrodéposition ou le claquage diélectrique.

  20. The future of stochastic and upscaling methods in hydrogeology

    NASA Astrophysics Data System (ADS)

    Nœtinger, Benoît; Artus, Vincent; Zargar, Ghassem

    2005-03-01

    and sensitivity studies in a global multiscale framework is emphasized. In particular, upscaling can help in finding the parameters that control the overall behavior of the flow. Finally, upscaling approaches of non-linear transport equations appear as a new frontier in this area of research. Les formations géologiques sont des entités complexes résultant de processus géologiques, mécaniques et physico-chimiques, à de larges palettes d'échelles de temps et d'espace. Les phénomènes de transport, qui sont définis de l'échelle moléculaire à l'échelle pluri-kilométrique, peut influencer le comportement global des écoulements dans les formations. Les hétérogénéités qui recouvrent plusieurs échelles spatiales jouent un rôle essentiel pour les écoulements canaliser, et plus spécialement lorsque les écoulements sont couplés avec des non-linéarités inhérentes aux processus de transport dans les milieux poreux. Les problémes ont une importance pratique considérable sur la gestion de l'eau souterraine, et dans l'industrie du pétrole, et plus particulièrement pour la résolution de nouveaux problèmes po sés par les projets concernés par le piégeage du CO2 en subsurface. De manière à gérer cette complexité, il faut être capable de donner la priorité aux influences respectives des phénomènes géologiques et physico-chimiques utiles, intervenant à différentes échelles de temps et d'espace, et comprendre et utiliser les modèles géostatistiques, riches et complexes, permettant de se munir de simulations réalistes des conditions de sub-surface. Les simulations de l'écoulement à plusieurs échelles, dans ces formations, peuvent aider les ingénieurs à se focaliser sur les phénomènes cruciaux qui contrôlent l'écoulement. Ceci apporte un cadre de travail pour intégrer les données, résoudre les problèmes inverses impliquant une grande quantité de données, résultant en une réduction de l'incertitude de la description de la

  1. Lignes directrices canadiennes sur l’utilisation sécuritaire et efficace des opioïdes pour la douleur chronique non cancéreuse

    PubMed Central

    Kahan, Meldon; Wilson, Lynn; Mailis-Gagnon, Angela; Srivastava, Anita

    2011-01-01

    édation, les chutes et la surdose peuvent être minimisées en utilisant des doses initiales faibles, un titrage plus lent, un sevrage des benzodiazépines et une bonne éducation des patients. Dans le cas des femmes enceintes qui prennent des opioïdes chaque jour, il faut faire un sevrage progressif et cesser complètement. Si ce n’est pas possible, il faut administrer la dose efficace la plus faible. Les femmes enceintes qui ont une dépendance aux opioïdes devraient recevoir un traitement à la méthadone. Les adolescents sont à risque élevé de surdose d’opioïdes, d’usage abusif et de dépendance. Les patients qui ont des adolescents qui vivent à la maison devraient entreposer leurs opioïdes dans un lieu sûr. Les adolescents ont rarement besoin d’une thérapie à long terme aux opioïdes. Conclusion Les médecins de famille doivent tenir compte de l’âge, de la condition psychiatrique, du degré de risque de dépendance du patient et d’autres facteurs quand ils prescrivent des opioïdes pour la douleur chronique.

  2. Cavity Enhanced absorption spectroscopy with an Optical Comb: Detection of atmospheric radicals in the near UV.

    NASA Astrophysics Data System (ADS)

    Méjean, G.; Kassi, S.; Romanini, D.

    2009-04-01

    The atmospheric chemistry community suffers a lack of fast, reliable and space resolved measurement for a wide set of very reactive molecules (e.g. radicals such as OH, NO3, BrO, IO, etc.). Due to their high reactivity, these molecules largely control the lifetime and concentration of numerous key atmospheric species. The concentrations of radicals are extremely low (ppbv or less) and highly variable in time and space. Measuring their concentration is often extremely laborious, expensive and requires heavy equipment (chemical sampling and treatment followed by mass spectrometry and/or chromatography). We recently introduced an optical spectroscopy technique based on a femtosecond laser oscillator, "Mode-Locked Cavity-Enhanced Absorption Spectroscopy", that we propose to develop into an instrument for in situ measurement of local concentration of traces of reactive molecules [1-3]. We have already demonstrated the possibility of measuring part in 1E12 by volume concentrations of radicals of high atmospheric interest, such as IO or BrO [4], as needed for monitoring these species in the environment. We apply cavity-enhanced absorption spectroscopy in the near UV range using a frequency-doubled Ti:Sa modelocked femtosecond laser. Efficient broadband injection of a high finesse cavity is obtained by matching this optical frequency-comb source to the comb of cavity transmission resonances. A grating spectrograph and a detector array disperse and detect the spectrum transmitted by the cavity carrying the absorption features of intracavity molecules. IO traces were obtained by mixing together controlled flows of gaseous iodine and ozone inside a high finesse cavity (F~6000). A Chameleon Ultra II ML-Laser (gracefully lent during 1 month by Coherent Inc.) was frequency doubled to address an absorption band of IO at 436 nm. A locking scheme allowed the cavity transmission to be smooth and stable. The transmitted light was dispersed using a high resolution (0.07nm) grating

  3. Mise au point d'un reacteur epitaxial CBE

    NASA Astrophysics Data System (ADS)

    Pelletier, Hubert

    Ce projet de maîtrise consiste à l'asservissement et la mise en marche d'un réacteur d'épi-taxie par jets chimiques au Laboratoire d'Épitaxie Avancée de l'Université de Sherbrooke. Le réacteur sert à la croissance dans l'ultravide de matériaux semi-conducteurs tels que l'arséniure de gallium (GaAs) et le phosphure d'indium-gallium (GaInP). La programmation LabVIEW et du matériel informatique de National Instruments sont utilisés pour asservir le réacteur. Le contrôle de la température de l'échantillon et de la pression de contrôle des réactifs de croissance dans le réacteur est assuré par des boucles de rétroaction. Ainsi, la température de l'échantillon est stabilisée à ±0, 4 °C, alors que les pressions de contrôle de gaz peuvent être modulées sur un ordre de grandeur en 2 à 4 secondes, et stabilisées à ±0, 002 Torr. Le système de pompage du réacteur a été amélioré suite à des mesures de vitesse de pompage d'une pompe cryogénique. Ces mesures révèlent une dégradation sur plus d'un ordre de grandeur de son pompage d'hydrogène avec l'opération à long terme. Le remplacement de la pompe cryogénique par une pompe turbo-moléculaire comme pompe principale a permis d'améliorer la fiabilité du système de pompage du système sous vide. D'autre part, la conductance du système d'acheminement de gaz et d'injection a été augmentée afin de réduire un effet mémoire des sources le système et faciliter la croissance de matériaux ternaires. Ainsi, des croissances de GaAs (100) sur substrat de même nature ont été effectuées et ont révélé un matériau de bonne qualité. Sa rugosité moyenne de 0,17 nm, mesurée par microscopie à force atomique, est très faible selon la littérature. De plus, une mobilité élevée des porteurs est obtenue à fort dopage au silicium, au tellure et au carbone, notamment une mobilité de 42 ± 9 cm2V -1s-1 des porteurs majoritaires '(trous) lors du dopage au

  4. Assessing total nitrogen in surface-water samples--precision and bias of analytical and computational methods

    USGS Publications Warehouse

    Rus, David L.; Patton, Charles J.; Mueller, David K.; Crawford, Charles G.

    2013-01-01

    concentrations up to 750 mg/L (median of -4.4 percent). This lent support to the laboratory-experime

  5. Obituary: William K. Rose (1935-2010)

    NASA Astrophysics Data System (ADS)

    Trimble, Virginia

    2011-12-01

    shells in stars and the instabilities in each. Almost equally memorable, when the Roses had to depart a few days before the end of the school, they left behind a perfectly magnificent cake for the students to share at the closing party. During the first year that I was a visiting assistant professor at the University of Maryland, Bill and I team-taught the very first of the astronomy program's courses designed to fulfill a new, junior-level breadth requirement. It was called "The Inconstant Universe." I did cosmology and be did high-energy astrophysics. We were also two of the three authors of a short paper called "A low mass primary for Cygnus X-1?" It pointed out that, if the primary of HDE 226868 was a low-mass, hot, short-lived helium star (on which each of us had published previous papers) then the solution of the radial velocity orbit, which came only from the lines of the OB primary, could yield a companion mass small enough for the X-ray emitting component to be a neutron star rather than a black hole. Such a system would be intrinsically much fainter than one with an OB supergiant primary, and so must be much closer to us than a supergiant plus black hole system. Our prediction resulted in two serious observers rushing to telescopes to look for interstellar absorption features in the optical spectrum of HDE 226868. They found lines with the velocity signatures of two spiral arms, thus placing the system at a large distance, giving it high luminosity and large mass. It was and is a black hole. The paper had the distinction of being the only one either of us ever wrote that was accepted and typeset before the postcard arrived by seamail to announce its receipt. Bill Rose lent his expertise to a wide range of topics, including models of X-ray and radio sources, magnetic fields, pulsar radiation mechanisms, formation of stars and black holes, and nucleosynthesis. Another much-cited paper, with Beatrice M. Tinsley, had a pun for its title: "Late stages of stellar

  6. Hydrochemical evaluation of groundwater in the Blue Nile Basin, eastern Sudan, using conventional and multivariate techniques

    NASA Astrophysics Data System (ADS)

    Hussein, Mohammed Tahir

    des techniques multidimensionnelles ont été appliquées pour atteindre ces objectifs. Deux niveaux aquifères existent dans cette région, la formation des grès nubiens et la formation Al-Atshan. L'aquifère nubien est surtout rechargé par le Nil Bleu et la rivière Dinder grâce à des écoulements souterrains latéraux et par l'infiltration directe de la pluie sur les affleurements. L'aquifère Al-Atshan reçoit l'eau par un écoulement souterrain depuis la rivière Rahad et par infiltration de la pluie. Les processus hydrochimiques déterminants sont la simple dissolution, le mélange, l'échange ionique partiel et l'échange ionique. Un échange ionique inverse limité a été mis en évidence dans l'aquifère nubien. Trois facteurs contrôlent l'ensemble de la minéralisation et la qualité de l'eau du bassin du Nil Bleu. Le premier facteur rend compte des valeurs élevées de la minéralisation, de la conductivité électrique, du sodium, du potassium, des chlorures, des bicarbonates, des sulfates et du magnésium. Le second facteur rend compte du calcium et du pH. Le troisième facteur est lié à la concentration en fluorures des eaux souterraines. L'étude souligne les aptitudes descriptives des techniques conventionnelles et multidimensionnelles en tant qu'outils efficaces d'évaluation de la qualité des eaux souterraines. Resumen La evaluación hidroquímica de sistemas hidrogeológicos puede llevarse a cabo mediante técnicas convencionales y multivariadas, como las de agrupamiento (``cluster''), análisis factorial y otras, incluyendo el análisis de correspondencia. El objetivo principal de este estudio es investigar la calidad de las aguas subterráneas en la cuenca del Nilo Azul, al este de Sudán, y deducir la hidrogeoquímica del sistema acuífero. Se ha aplicado métodos convencionales y técnicas multivariadas para lograr dicho objetivo. Hay dos niveles acuíferos en la zona de estudio: la Formación Arenisca de Nubia y la Formación Al

  7. Aquifers and hyporheic zones: Towards an ecological understanding of groundwater

    NASA Astrophysics Data System (ADS)

    Hancock, Peter J.; Boulton, Andrew J.; Humphreys, William F.

    2005-03-01

    biotopes souterrains à des études multidisciplinaires qui intègrent l'écologie et l'hydrogéologie. L'approche multidisciplinaire cherche à élucider le fonctionnement des écosystèmes souterrains et leur rôle consistant à maintenir la qualité des eaux souterraines et de surface. Dans les écotones des eaux de la surfaces des aquifères, les gradients géochimiques et les biofilms microbiologiques contrôlent les transformations de la qualité de l'eau. La faune de subsurface (stygofauna) construisent les biofilms, altèrent la taille des pores interstitiels à travers leur mouvement, et transportent physiquement des matériaux à travers l'environnement des eaux souterraines. Par ailleurs, les changements de leur population signalent un déclin de la qualité de l'eau. Une meilleure intégration de l'écologie des eaux souterraines, de la biogeochimie, et de l'hydrogéologie pourra faire avancer de manière efficace de notre compréhension des écosystèmes souterrains, et spécialement en terme de bioremédiation des eaux souterraines contaminées, de maintenance et d'amélioration de la qualité des eaux de surface dépendant des écosystèmes souterrains, et l'amélioration de la protection des habitats des eaux souterraines durant l'extraction des ressources naturelles. En général, cela conduira à une meilleure compréhension de l'implication de l'hydrogéologie et de la géologie des aquifères à la distribution de la faune de subsurface et aux microbiota, aux processus écologiques tels que les cycles du carbone, et la gestion durable des eaux souterraines. Los entornos ecológicos en ambientes subsuperficiales están relacionados directamente con el flujo de agua subterránea, la conductividad hidráulica, biogeoquímica intersticial, tamaño de los poros, y vínculos hidrológicos con acuíferos adyacentes y ecosistemas superficiales. La ecología del agua subterránea ha evolucionado a partir de una ciencia que describe la biota subterránea única

  8. Assessing total nitrogen in surface-water samples--precision and bias of analytical and computational methods

    USGS Publications Warehouse

    Rus, David L.; Patton, Charles J.; Mueller, David K.; Crawford, Charles G.

    2013-01-01

    concentrations up to 750 mg/L (median of -4.4 percent). This lent support to the laboratory-experiment finding that some particulate nitrogen is sequestered during the digestion process, and demonstrated that negative TN-A bias was present in samples with very low suspended-sediment concentrations. At sediment concentrations above 750 mg/L, the negative TN-A bias became more likely and larger (median of -13.2 percent), suggesting a secondary mechanism of bias, such as reagent limitation. From a geospatial perspective, trends in TN-A bias were not explained by selected basin characteristics. Though variable, TN-K bias generally was positive in the synoptic-field study (median of 3.1 percent), probably as a result of the reduction of nitrate. Three alternative approaches for assessing TN in surface water were evaluated for their impacts on existing and future sampling programs. Replacing TN-A with TN-C would remove the bias from subsequent data, but this approach also would introduce discontinuity in historical records. Replacing TN-K with TN-C would lead to the removal of positive bias in TN-K in the presence of elevated nitrate. However, in addition to the issues that may arise from a discontinuity in the data record, this approach may not be applicable to regulatory programs that require the use of total Kjeldahl nitrogen for stream assessment. By adding TN-C to existing TN-A or TN-K analyses, historical-data continuity would be preserved and the transitional period could be used to minimize the impact of bias on data analyses. This approach, however, imposes the greatest burdens on field operations and in terms of analytical costs. The variation in these impacts on different sampling programs will challenge U.S. Geological Survey scientists attempting to establish uniform standards for TN sample collection and analytical determinations.

  9. Equation of State and Structure of Electrostatic Colloidal Crystals: Osmotic Pressure and Scattering Study

    NASA Astrophysics Data System (ADS)

    Reus, V.; Belloni, L.; Zemb, T.; Lutterbach, N.; Versmold, H.

    1997-04-01

    structure et les interactions interparticulaires en fonction de la fraction volumique à salinité constante de l'ordre de la micromole/l. Lorsque la cristallisation est lente, nous observons des cristaux parfaits cubiques centrés par diffusion de lumière pour des fractions volumiques comprises entre 0,04 et 0,7 % et cubiques faces centrées pax diffusion de rayons X aux petits angles pour des fractions volumiques plus élevées (2 12 %). Après cisaillement, des défauts apparaissent dans les cristaux ; ils sont caractérisés par la disparition de certaines raies de Bragg en diffusion de lumière pour des échantillons de fraction volumique comprise entre 0,1 et 0,3 % et par la présence d'un pré pic observé par diffusion de rayons X aux petits angles avant le premier pic de Bragg, pour des échantillons plus concentrés (2 12 %). Les pressions osmotiques ont été mesurées par différence de pression hydrostatique entre la solution et le réservoir séparés par une membrane hémiperméable. Les données expérimentales sont bien reproduites par la théorie Poisson Boltzmann Réseau (PBR) qui montre que les interactions sont purement répulsives. Aucune force attractive faible de longue portée n'a été détectée expérimentalement. En calculant le déplacement moyen d'une particule à l'intérieur de sa cage à l'aide du modèle PBR "excentré", nous avons vérifié que le critère de Lindemann était satisfait pour tous les cristaux observés. Cette étude a permis de déterminer l'équation d'état d'un cristal colloidal électrostatique. Les résultats sont équivalents à une mesure de force ultraprécise puisque les forces d'interaction mesurées entre particules sont de l'ordre de 10^{-12} N pour des distances centre à centre de l'ordre de 4000 Å.

  10. A Disturbed Galactic Duo

    NASA Astrophysics Data System (ADS)

    2011-04-01

    The galaxies in this cosmic pairing, captured by the Wide Field Imager on the MPG/ESO 2.2-metre telescope at the La Silla Observatory in Chile, display some curious features, demonstrating that each member of the duo is close enough to feel the distorting gravitational influence of the other. The gravitational tug of war has warped the spiral shape of one galaxy, NGC 3169, and fragmented the dust lanes in its companion NGC 3166. Meanwhile, a third, smaller galaxy to the lower right, NGC 3165, has a front-row seat to the gravitational twisting and pulling of its bigger neighbours. This galactic grouping, found about 70 million light-years away in the constellation Sextans (The Sextant), was discovered by the English astronomer William Herschel in 1783. Modern astronomers have gauged the distance between NGC 3169 (left) and NGC 3166 (right) as a mere 50 000 light-years, a separation that is only about half the diameter of the Milky Way galaxy. In such tight quarters, gravity can start to play havoc with galactic structure. Spiral galaxies like NGC 3169 and NGC 3166 tend to have orderly swirls of stars and dust pinwheeling about their glowing centres. Close encounters with other massive objects can jumble this classic configuration, often serving as a disfiguring prelude to the merging of galaxies into one larger galaxy. So far, the interactions of NGC 3169 and NGC 3166 have just lent a bit of character. NGC 3169's arms, shining bright with big, young, blue stars, have been teased apart, and lots of luminous gas has been drawn out from its disc. In NGC 3166's case, the dust lanes that also usually outline spiral arms are in disarray. Unlike its bluer counterpart, NGC 3166 is not forming many new stars. NGC 3169 has another distinction: the faint yellow dot beaming through a veil of dark dust just to the left of and close to the galaxy's centre [1]. This flash is the leftover of a supernova detected in 2003 and known accordingly as SN 2003cg. A supernova of this

  11. Comportement de frittés et de films d'oxyde de titane en présence d'atmosphères gazeuses, hors équilibre thermodynamique, en régime stationnaire; application aux capteurs résistifs d'oxygène

    NASA Astrophysics Data System (ADS)

    Jerisian, R.; Gautron, J.; Loup, J. P.

    1992-04-01

    mesurée, en régime stationnaire, en fonction du débit des gaz ; ces atmosphères sont d'autant plus éloignées de l'équilibre que le débit est élevé. On montre que les variations de résistance des échantillons, en fonction du débit, dépendent du domaine de pression partielle d'oxygène, de la température et de la structure des échantillons. La sensibilité à l'oxygène est accrue par un morphologie qui, à l'échelle macroscopique, favorise la diffusion de l'oxygène et qui, à l'échelle microscopique, permet la création de barrière de potentiel aux joints de grains. En milieu oxydant, à 870 K, un mécanisme de volume qui met en jeu la cinétique des échanges avec la phase gazeuse, détermine une variation de résistance en P_{O_2}^{1/4}/P_{CO}^{1/2}. En milieu réducteur, à la même température, la non-stœchiométrie en volume de l'oxyde est fixée par le couple redox CO/CO2 comme si l'atmosphère était en équilibre thermodynamique. Mais l'abondance des électrons de conduction, favorise la chimisorption de l'oxygène qui contrôle la résistance des couches selon une loi en P_{O_2}^{1/2} en créant des barrières de potentiel à la surface des grains. Des modèles, permettant le calcul du potentiel de surface ainsi que du taux de recouvrement, sont développés ; la comparaison des modèles indique une diffusion relativement lente des lacunes d'oxygène à 870 K. A 1 100 K, l'atmosphère tend à être à l'équilibre thermodynamique : i) en atmosphère oxydante, tous les capteurs sont en équilibre avec la pression partielle d'oxygène ; ii) en atmosphère réductrice, dominée par le couple redox CO/CO2, seules les couches sont sensibles à la présence de traces d'oxygène.

  12. Impacts of afforestation on groundwater resources and quality

    NASA Astrophysics Data System (ADS)

    Allen, Alistair; Chapman, Deborah

    2001-07-01

    que des pratiques forestières non coordonnées sont susceptibles d'exacerber les crues. La recharge des nappes est affectée par la foresterie, surtout à cause de prélèvements plus importants de l'eau du sol par les arbres et à cause de la capacité accrue des sols forestiers à retenir de l'eau, conduisant à de plus fortes teneurs en matières organiques. Les taux de recharge sous les forêts peuvent être réduits d'un dixième par rapport à la prairie ou à la lande. La qualité de l'eau souterraine peut être affectée par une acidification accrue et par une nitrification sous les forêts, provoquées pour une part par une fixation des polluants atmosphériques par le couvert forestier et pour une autre part par un dépôt plus important d'une litière plus fortement acide. Les taux de recharge plus lente des nappes sous les forêts conduisent à des retards importants dans la manifestation de la détérioration de la qualité de l'eau souterraine. Resumen. Se han iniciado los planes para duplicar la proporción de terrenos reforestados en Irlanda hacia el año 2035. El plan, impulsado por fines económicos, ignora los impactos potenciales medioambientales de la silvicultura, y, en particular, los impactos a los recursos de aguas subterráneas y a su calidad. Puesto que el 25 % del agua potable en Irlanda es suministrada por medio de aguas subterráneas, dichos impactos son importantes. Las investigaciones de campo indican que la reforestación lleva a una reducción de la escorrentía de hasta un 20 %, fundamentalmente por la interceptación de la lluvia en las copas de los árboles, mientras que la deforestación tiene el impacto opuesto. Las implicaciones son tales que las prácticas forestales descoordinadas pueden aumentar enormemente el riesgo de inundaciones. También la recarga a los acuíferos se ve afectada por la reforestación, debido, sobre todo, al uso del agua del suelo por los árboles y a la mayor capacidad de retención de los suelos en

  13. Aquifers and hyporheic zones: Towards an ecological understanding of groundwater

    NASA Astrophysics Data System (ADS)

    Hancock, Peter J.; Boulton, Andrew J.; Humphreys, William F.

    2005-03-01

    biotopes souterrains à des études multidisciplinaires qui intègrent l'écologie et l'hydrogéologie. L'approche multidisciplinaire cherche à élucider le fonctionnement des écosystèmes souterrains et leur rôle consistant à maintenir la qualité des eaux souterraines et de surface. Dans les écotones des eaux de la surfaces des aquifères, les gradients géochimiques et les biofilms microbiologiques contrôlent les transformations de la qualité de l'eau. La faune de subsurface (stygofauna) construisent les biofilms, altèrent la taille des pores interstitiels à travers leur mouvement, et transportent physiquement des matériaux à travers l'environnement des eaux souterraines. Par ailleurs, les changements de leur population signalent un déclin de la qualité de l'eau. Une meilleure intégration de l'écologie des eaux souterraines, de la biogeochimie, et de l'hydrogéologie pourra faire avancer de manière efficace de notre compréhension des écosystèmes souterrains, et spécialement en terme de bioremédiation des eaux souterraines contaminées, de maintenance et d'amélioration de la qualité des eaux de surface dépendant des écosystèmes souterrains, et l'amélioration de la protection des habitats des eaux souterraines durant l'extraction des ressources naturelles. En général, cela conduira à une meilleure compréhension de l'implication de l'hydrogéologie et de la géologie des aquifères à la distribution de la faune de subsurface et aux microbiota, aux processus écologiques tels que les cycles du carbone, et la gestion durable des eaux souterraines. Los entornos ecológicos en ambientes subsuperficiales están relacionados directamente con el flujo de agua subterránea, la conductividad hidráulica, biogeoquímica intersticial, tamaño de los poros, y vínculos hidrológicos con acuíferos adyacentes y ecosistemas superficiales. La ecología del agua subterránea ha evolucionado a partir de una ciencia que describe la biota subterránea única

  14. Etude des interdiffusions en phase solide dans le contact Ni/AlAs

    NASA Astrophysics Data System (ADS)

    Députier, S.; Guivarc'h, A.; Caulet, J.; Poudoulec, A.; Guenais, B.; Minier, M.; Guérin, R.

    1995-04-01

    éposée dans des conditions d'ultra-vide et des couches épaisses d'AlAs épitaxiées sur des substrats de GaAs orientés (001) et (111) ont été étudiées après des traitements thermiques d'une heure, sous balayage de gaz neutres, entre 200 et 600 ^{circ}C. L'utilisation de techniques complémentaires d'analyse (RBS, diffraction X, MET) a permis de mettre en évidence, en fonction de la température de recuit, plusieurs étapes successives d'interaction. Ces étapes correspondent soit à des phases ternaires, mises en évidence lors de la détermination expérimentale du diagramme Ni-Al-As et notées A, B, D par analogie avec celles du diagramme Ni-Ga-As, soit à des mélanges de phases constituées de binaires et/ou de ternaires, toutes ces phases étant plus ou moins fortement texturées sur le substrat. En fait, la nature des phases en présence dépend de l'orientation du substrat, la cinétique de réaction apparaissant plus lente pour l'interaction Ni/AlAs(111) que pour celle Ni/AlAs(001), les étapes successives sont observées : tout d'abord un mélange constitué de la phase ternaire B + NiAl puis un autre mélange : phase ternaire A + NiAl + NiAs et en fin d'interaction les deux binaires : NiAl + NiAs. Sur AlAs(111), seules deux étapes sont mises en évidence, la première correspond à la phase ternaire D, la seconde, en fin d'interaction, est constituée du mélange : phase B + NiAl + NiAs. On remarque dans ce cas le recuit à 600 ^{circ}C n'est pas suffisant pour atteindre le mélange des binaires NiAl et NiAs qui, selon le diagramme ternaire, est le stade ultime de l'interaction Ni/AlAs. L'analyse comparée des interdiffusions Ni/AlAs et Ni/GaAs montre que NiAl est le composé “clé” autour duquel pivote l'interaction Ni/AlAs alors que ce rôle était joué par NiAs lors des interdiffusions Ni/GaAs. Thermiquement stable et fortement texturé sur AlAs, le binaire NiAl apparaît comme un candidat prometteur pour la réalisation d'hétérostructures NiAl/AlAs/GaAs.

  15. Obituary: William K. Rose (1935-2010)

    NASA Astrophysics Data System (ADS)

    Trimble, Virginia

    2011-12-01

    shells in stars and the instabilities in each. Almost equally memorable, when the Roses had to depart a few days before the end of the school, they left behind a perfectly magnificent cake for the students to share at the closing party. During the first year that I was a visiting assistant professor at the University of Maryland, Bill and I team-taught the very first of the astronomy program's courses designed to fulfill a new, junior-level breadth requirement. It was called "The Inconstant Universe." I did cosmology and be did high-energy astrophysics. We were also two of the three authors of a short paper called "A low mass primary for Cygnus X-1?" It pointed out that, if the primary of HDE 226868 was a low-mass, hot, short-lived helium star (on which each of us had published previous papers) then the solution of the radial velocity orbit, which came only from the lines of the OB primary, could yield a companion mass small enough for the X-ray emitting component to be a neutron star rather than a black hole. Such a system would be intrinsically much fainter than one with an OB supergiant primary, and so must be much closer to us than a supergiant plus black hole system. Our prediction resulted in two serious observers rushing to telescopes to look for interstellar absorption features in the optical spectrum of HDE 226868. They found lines with the velocity signatures of two spiral arms, thus placing the system at a large distance, giving it high luminosity and large mass. It was and is a black hole. The paper had the distinction of being the only one either of us ever wrote that was accepted and typeset before the postcard arrived by seamail to announce its receipt. Bill Rose lent his expertise to a wide range of topics, including models of X-ray and radio sources, magnetic fields, pulsar radiation mechanisms, formation of stars and black holes, and nucleosynthesis. Another much-cited paper, with Beatrice M. Tinsley, had a pun for its title: "Late stages of stellar

  16. New Fragment Separation Technology for Superheavy Element Research

    SciTech Connect

    Shaughnessy, D A; Moody, K J; Henderson, R A; Kenneally, J M; Landrum, J H; Lougheed, R W; Patin, J B; Stoyer, M A; Stoyer, N J; Wild, J F; Wilk, P A

    2008-01-28

    found that the efficiency of transporting products from the target chamber to the detector array was much too low for applications in heavy element experiments where production rates are on the order of one atom per day or less. Work continues on the MASHA separator, and once the efficiency has been improved, we plan to continue our work on the Pu target for future element 114 experiments. Due to the delays of the MASHA separator, work on establishing the identity of heavy element species produced through nuclear reactions focused instead on chemical separations. In particular, element 115 decays through a series of alpha decays, terminating with an element 105 isotope with a long half-life ({approx} 1 day). By chemically separating the element 105 daughter and observing its subsequent fission decay, the identity of the original parent nucleus can be established through the genetic correlation of the initial series of alpha decays. Chemical separations of element 105 were developed in Switzerland, Russia, and at LLNL. Over the course of two experiments, reaction products from the {sup 243}Am+{sup 48}Ca reaction were collected in a copper block and subsequently processed for chemical separation of the Group Five elements [8,9,13,15]. The Group Five elements were initially separated from the Group Four species, and then the samples were sub-divided into tantalum and niobium fractions. All of the fission events were observed in the tantalum fractions, which implied that element 105 behaved more like tantalum under the chemical conditions of these experiments. These experiments were very successful, and not only demonstrated that chemical separation could be performed on single atoms of interest, but also lent proof to the identity of the parent nucleus as element 115. Subsequent analysis of the alpha spectra taken during the experiment further prove that the fission events observed during the two experiments came from element 105 as the decay daughter of element 115 and

  17. Hydrochemical evaluation of groundwater in the Blue Nile Basin, eastern Sudan, using conventional and multivariate techniques

    NASA Astrophysics Data System (ADS)

    Hussein, Mohammed Tahir

    des techniques multidimensionnelles ont été appliquées pour atteindre ces objectifs. Deux niveaux aquifères existent dans cette région, la formation des grès nubiens et la formation Al-Atshan. L'aquifère nubien est surtout rechargé par le Nil Bleu et la rivière Dinder grâce à des écoulements souterrains latéraux et par l'infiltration directe de la pluie sur les affleurements. L'aquifère Al-Atshan reçoit l'eau par un écoulement souterrain depuis la rivière Rahad et par infiltration de la pluie. Les processus hydrochimiques déterminants sont la simple dissolution, le mélange, l'échange ionique partiel et l'échange ionique. Un échange ionique inverse limité a été mis en évidence dans l'aquifère nubien. Trois facteurs contrôlent l'ensemble de la minéralisation et la qualité de l'eau du bassin du Nil Bleu. Le premier facteur rend compte des valeurs élevées de la minéralisation, de la conductivité électrique, du sodium, du potassium, des chlorures, des bicarbonates, des sulfates et du magnésium. Le second facteur rend compte du calcium et du pH. Le troisième facteur est lié à la concentration en fluorures des eaux souterraines. L'étude souligne les aptitudes descriptives des techniques conventionnelles et multidimensionnelles en tant qu'outils efficaces d'évaluation de la qualité des eaux souterraines. Resumen La evaluación hidroquímica de sistemas hidrogeológicos puede llevarse a cabo mediante técnicas convencionales y multivariadas, como las de agrupamiento (``cluster''), análisis factorial y otras, incluyendo el análisis de correspondencia. El objetivo principal de este estudio es investigar la calidad de las aguas subterráneas en la cuenca del Nilo Azul, al este de Sudán, y deducir la hidrogeoquímica del sistema acuífero. Se ha aplicado métodos convencionales y técnicas multivariadas para lograr dicho objetivo. Hay dos niveles acuíferos en la zona de estudio: la Formación Arenisca de Nubia y la Formación Al

  18. Occurrence of springs in massifs of crystalline rocks, northern Portugal

    NASA Astrophysics Data System (ADS)

    Pacheco, Fernando António Leal; Alencoão, Ana Maria Pires

    2002-02-01

    croisés, les distributions des sources par ensemble de fractures ont été comparées aux situations géologiques et aux écarts liés aux différences dans les structures des roches et, probablement, aux différences dans leurs histoires de déformations. Les relations entre la fréquence des sources et la structure des roches ont été étudiées ensuite par détermination spectrale, modèle présenté dans cette étude. Les données d'entrée sont les fréquences des sources et les longueurs des fractures dans chaque domaine géologique, en plus des angles entre directions de fractures et orientation du champ de contraintes actuel (θ). La sortie du modèle donne les densités dites intrinsèques, un paramètre indexant l'existence d'une source à des facteurs tels que le type de fracture et le régime et l'âge associés de la déformation. Les densités les plus fortes (12,2 sources par km de linéament) ont été associées à des fractures jeunes produites par des déformations lentes, et les plus faibles (0,1) aux fractures anciennes ductiles et de tension. La détermination spectrale associe également chaque classe d'orientation à un paramètre structural dominant: quand la présence d'une source est contrôlée par θ, la classe est parallèle à l'orientation actuelle du champ de contrainte; lorsque le contrôle est attribué à la longueur des fractures, la présence de sources suit le plan des failles normales à grande échelle traversant la région. Resumen. Se ha llevado a cabo un inventario de manantiales emergentes de fracturas (manantiales de fracturas) en la cuenca del Río Pinhão y en el Macizo de Morais. El área estudiada ocupa unos 650 km2 y se halla al Norte de Portugal. Se ha identificado más de 1.500 manantiales, los cuales han sido asociados con dominios geológicos y conjuntos de fracturas. Mediante el Análisis de la Tabulación Cruzada, se ha comparado la distribución de los manantiales por conjuntos de fracturas entre ambientes geol

  19. Kuwait.

    PubMed

    1988-03-01

    ,000 barrels per day. Other industrial products include ammonia, chemical fertilizers, fishing and water desalinization (215 million gallons a day). Kuwait imports machinery, manufactured goods, and food. Nevertheless exports exceed imports by $2 billion, and the Kuwaiti dinar is a strong currency (1 KD=US$3.57). About $75 billion is kept in 2 reserve funds: the Fund for Future Generations and the General Reserve Fund. In addition to domestic expenditures and imports, Kuwait has extended $5 billion worth of loans to developing countries, made through the Kuwait Fund for Arab Economic Development. Kuwait has been engaged in continuing border disputes with Iraq since 1961, but the most immediate threat to Kuwait has been the Iran-Iraq war. Kuwait lent Iraq $6 billion, in retaliation for which Iran bombed a Kuwaiti oil depot, and Shi'a Muslim terrorists bombed the French and US embassies and hijacked a Kuwaiti airliner in 1984. Iran also attacked Kuwaiti tankers. In 1987 the US reflagged 11 Kuwaiti tankers to protect them from Iranian attacks. Kuwait has been modernizing its own military forces as well as purchasing sophisticated weapons from the UK, the US, France, and the USSR. In 1981 Kuwait, Saudi Arabia, Bahrain, Qatar, the United Arab Emirates and Oman formed the Gulf Cooperation Council (GCC) for mutual defense, and in 1987 Kuwait was elected chairman of the Organization of the Islamic Conference (OIC). Kuwait has diplomatic relations with the USSR and the People's Republic of China, as well as with the US, which has supplied Kuwait with $1.5 billion of sophisticated weaponry from foreign military sales (FMC). The US is Kuwait's largest supplier (after Japan), and Kuwait is the 5th largest market in the Middle East for US goods, despite the disincentives brought about by the Arab boycott of Israel. PMID:12177972

  20. Groundwater recharge and chemical evolution in the southern High Plains of Texas, USA

    NASA Astrophysics Data System (ADS)

    Fryar, Alan; Mullican, William; Macko, Stephen

    2001-11-01

    The unconfined High Plains (Ogallala) aquifer is the largest aquifer in the USA and the primary water supply for the semiarid southern High Plains of Texas and New Mexico. Analyses of water and soils northeast of Amarillo, Texas, together with data from other regional studies, indicate that processes during recharge control the composition of unconfined groundwater in the northern half of the southern High Plains. Solute and isotopic data are consistent with a sequence of episodic precipitation, concentration of solutes in upland soils by evapotranspiration, runoff, and infiltration beneath playas and ditches (modified locally by return flow of wastewater and irrigation tailwater). Plausible reactions during recharge include oxidation of organic matter, dissolution and exsolution of CO2, dissolution of CaCO3, silicate weathering, and cation exchange. Si and 14C data suggest leakage from perched aquifers to the High Plains aquifer. Plausible mass-balance models for the High Plains aquifer include scenarios of flow with leakage but not reactions, flow with reactions but not leakage, and flow with neither reactions nor leakage. Mechanisms of recharge and chemical evolution delineated in this study agree with those noted for other aquifers in the south-central and southwestern USA. Résumé. L'aquifère libre des Hautes Plaines (Ogallala) est le plus vaste aquifère des états-Unis et la ressource de base pour l'eau potable de la région semi-aride du sud des Hautes Plaines du Texas et du Nouveau-Mexique. Des analyses de l'eau et des sols prélevés au nord-est d'Amarillo (Texas), associées à des données provenant d'autres études dans cette région, indiquent que des processus intervenant au cours de l'infiltration contrôlent la composition de l'eau de la nappe libre dans la moitié septentrionale du sud des Hautes Plaines. Les données chimiques et isotopiques sont compatibles avec une séquence de précipitation épisodique, avec la reconcentration en solut

  1. Hurricane Katrina as a "teachable moment"

    NASA Astrophysics Data System (ADS)

    Glantz, M. H.

    2008-04-01

    By American standards, New Orleans is a very old, very popular city in the southern part of the United States. It is located in Louisiana at the mouth of the Mississippi River, a river which drains about 40% of the Continental United States, making New Orleans a major port city. It is also located in an area of major oil reserves onshore, as well as offshore, in the Gulf of Mexico. Most people know New Orleans as a tourist hotspot; especially well-known is the Mardi Gras season at the beginning of Lent. People refer to the city as the "Big Easy". A recent biography of the city refers to it as the place where the emergence of modern tourism began. A multicultural city with a heavy French influence, it was part of the Louisiana Purchase from France in early 1803, when the United States bought it, doubling the size of the United States at that time. Today, in the year 2007, New Orleans is now known for the devastating impacts it withstood during the onslaught of Hurricane Katrina in late August 2005. Eighty percent of the city was submerged under flood waters. Almost two years have passed, and many individuals and government agencies are still coping with the hurricane's consequences. And insurance companies have been withdrawing their coverage for the region. The 2005 hurricane season set a record, in the sense that there were 28 named storms that calendar year. For the first time in hurricane forecast history, hurricane forecasters had to resort to the use of Greek letters to name tropical storms in the Atlantic and Gulf (Fig.~1). Hurricane Katrina was a Category 5 hurricane when it was in the middle of the Gulf of Mexico, after having passed across southern Florida. At landfall, Katrina's winds decreased in speed and it was relabeled as a Category 4. It devolved into a Category 3 hurricane as it passed inland when it did most of its damage. Large expanses of the city were inundated, many parts under water on the order of 20 feet or so. The Ninth Ward, heavily

  2. A Disturbed Galactic Duo

    NASA Astrophysics Data System (ADS)

    2011-04-01

    The galaxies in this cosmic pairing, captured by the Wide Field Imager on the MPG/ESO 2.2-metre telescope at the La Silla Observatory in Chile, display some curious features, demonstrating that each member of the duo is close enough to feel the distorting gravitational influence of the other. The gravitational tug of war has warped the spiral shape of one galaxy, NGC 3169, and fragmented the dust lanes in its companion NGC 3166. Meanwhile, a third, smaller galaxy to the lower right, NGC 3165, has a front-row seat to the gravitational twisting and pulling of its bigger neighbours. This galactic grouping, found about 70 million light-years away in the constellation Sextans (The Sextant), was discovered by the English astronomer William Herschel in 1783. Modern astronomers have gauged the distance between NGC 3169 (left) and NGC 3166 (right) as a mere 50 000 light-years, a separation that is only about half the diameter of the Milky Way galaxy. In such tight quarters, gravity can start to play havoc with galactic structure. Spiral galaxies like NGC 3169 and NGC 3166 tend to have orderly swirls of stars and dust pinwheeling about their glowing centres. Close encounters with other massive objects can jumble this classic configuration, often serving as a disfiguring prelude to the merging of galaxies into one larger galaxy. So far, the interactions of NGC 3169 and NGC 3166 have just lent a bit of character. NGC 3169's arms, shining bright with big, young, blue stars, have been teased apart, and lots of luminous gas has been drawn out from its disc. In NGC 3166's case, the dust lanes that also usually outline spiral arms are in disarray. Unlike its bluer counterpart, NGC 3166 is not forming many new stars. NGC 3169 has another distinction: the faint yellow dot beaming through a veil of dark dust just to the left of and close to the galaxy's centre [1]. This flash is the leftover of a supernova detected in 2003 and known accordingly as SN 2003cg. A supernova of this

  3. [Secondary hypothyroidism after cervical irradiation: systematic evaluation of thyroid function in follow-up].

    PubMed

    Gonçalves, Sara Monteiro; Ferreira, Brígida Costa; Guardado, Maria João; Marques, Rui; Serra, Tânia; Serra, Maria João; Roda, Domingos; Brandão, Joana; Melo, Gilberto; Lopes, Maria Carmo; Khouri, Leila

    2014-01-01

    Introdução: A disfunção tiroideia constitui uma consequência, por vezes subestimada, da exposição à radiação. O mecanismo subjacente não está claramente esclarecido, mas terá uma origem multifatorial. Os fatores de risco específicos para o desenvolvimento de hipotiroidismo secundário à radioterapia permanecem indeterminados. A irradiação direta da glândula tiroideia pode resultar, com maior frequência, em hipotiroidismo. Este é uma condição irreversível, requerendo monitorização e tratamento permanente. Objetivos: Avaliar a incidência de hipotiroidismo nos doentes portadores de neoplasias da cabeça e pescoço submetidos a irradiação cervical, a título intensivo ou adjuvante, bem como determinar se é justificável a integração no protocolo de seguimento Institucional, de parâmetros laboratoriais (TSH, T3 Livre e T4 Livre) para avaliação da função tiroideia neste grupo de doentes e qual a sua periodicidade. Material e Métodos: Este é um estudo observacional, descritivo, retrospetivo, que engloba um grupo de 376 doentes portadores de neoplasias da cabeça e pescoço, submetidos a tratamento de radioterapia, a título adjuvante ou intensivo, entre os anos de 2007 e 2012, no Instituto Português de Oncologia de Coimbra Francisco Gentil E.P.E. Cumpriram todos os critérios de inclusão 145 doentes. Foram utilizadas escalas de avaliação padronizadas para a definição de hipotiroidismo – LENT-SOMA scales (Late Effects Normal Tissues Subjective Objective Management Analysis). Foi considerada como complicação o hipotiroidismo Grau 1 ou superior. Resultados: Procedeu-se à análise de um grupo de 145 doentes. A localização tumoral mais frequente foi a Laringe (26,9%). Trinta e dois doentes efetuaram radioterapia adjuvante e 113 efetuaram esquemas intensivos. A técnica de radioterapia mais utilizada foi a intensidade modulada (IMRT), efetuada em 86,2% doentes. A taxa de incidência global de hipotiroidismo aos 12 meses foi de

  4. Simulation Training in Obstetrics and Gynaecology Residency Programs in Canada.

    PubMed

    Sanders, Ari; Wilson, R Douglas

    2015-11-01

    Objectif : L’intégration de la simulation aux programmes de résidence se déroule à un rythme plus lent en obstétrique-gynécologie que dans d’autres spécialités chirurgicales. Cette étude avait pour objectif d’évaluer l’utilisation actuelle de la simulation au sein des programmes canadiens de résidence en obstétrique-gynécologie. Méthodes : Nous avons conçu un sondage de 19 questions que nous avons distribué aux 16 programmes canadiens actifs et agréés de résidence en obstétrique-gynécologie. Le sondage a d’abord été transmis aux directeurs de programme; toutefois, nous l’avons occasionnellement redirigé vers d’autres membres du corps professoral participant à l’enseignement prodigué aux résidents ou vers des résidents de dernière année. Les réponses au sondage ont été recueillies sur une période de 18 mois. Résultats : Douze programmes ont répondu au sondage (11 d’entre eux ont fourni des réponses complètes). Onze programmes (92 %) ont signalé qu’ils intégraient un curriculum de simulation en obstétrique-gynécologie dans leurs cours offerts aux résidents. Tous les répondants (100 %) avaient accès à un centre de simulation. La simulation était utilisée pour l’enseignement de diverses compétences en obstétrique-gynécologie, par l’intermédiaire de différentes modalités de simulation. Parmi les obstacles à l’intégration de la simulation, on trouvait principalement les coûts du matériel et de l’espace requis, ainsi que la nécessité de réserver du temps aux fins de la simulation tant pour les résidents que pour les éducateurs. La majorité des programmes ont indiqué que l’amélioration de leur curriculum de simulation et la transition vers une évaluation des résidents fondée sur les compétences constituaient une priorité à leurs yeux. Conclusion : La formation au moyen de la simulation a gagné en popularité au sein des programmes de résidence en obst

  5. New Evidence from Silica Debris Exo-Systems for Planet Building Hypervelocity Impacts

    NASA Astrophysics Data System (ADS)

    Lisse, Carey

    2010-05-01

    versus re-condensation into a solid body like the Moon is short, though, ~ 103 to 104 yrs [5]. Credence is lent to this scenario by observations of the Jovian impact in July 2009 [6], where absorption features due to silica have been found superimposed on those of hot ammonia at the > 60 km/s impact site (Fig. 1). (2) Ongoing multiple small hypervelocity impacts continuously grinding down a distribution of large circumstellar particles above the blowout size limit (the 'rubble' identified in [4]) and releasing silica rich material and SiO gas. This model would require a massive (>1 MMoon) belt of 10 μm - 1 cm particles with inclinations spread out over at least ±45o [4] or dust on highly eccentric orbits [7]. The amount of material implied by the relative amplitude of the rubble spectral feature is consistent with the amount needed to collisionally produce the fine silica dust [4, 8]. A body rapidly re-accreting in a debris ring after collisional disruption (like the Moon) would have similar behavior (lots of impacts for some time, producing gas and little melt droplets). (3) A single impact onto a silica-rich object with already highly differentiated surface layers. For a very young system at 10 - 20 Myr when we expect planets to be rapidly accreting, a Mercury or larger-sized rocky body covered in an SiO rich magma ocean is very likely by the Jeans energy criterion [9], even without considering additional heating input by 26Al and other radioactives. For the lowest expected impact velocities,v MercuryEscape = 4 km/s, a pre-existing magma ocean in equilibrium with a surrounding SiO atmosphere would be required; at higher velocities the impacting body could be the formative mechanism for the magma ocean [10]. Further evidence for excess circumstellar emission due to silica dust have now been found. The youngest of these, HD154263, at ~20 Myr age shows evidence for SiO gas and amorphous + crystalline silica. The 2 older systems, HD23514 at ~100 Myr age, and HD15407 at

  6. Caractérisation des changements de phase développés dans un alliage AMF du type Cu Al Ni, par dilatométrie de trempe et microcalorimétrie différentielle

    NASA Astrophysics Data System (ADS)

    Bouabdallah, M.; Cizeron, G.

    1998-02-01

    température plus élevée, la phase β_1 se désordonne pour donner la phase β dont la structure est du type A_2. Au refroidissement, la mise en ordre βrightarrowβ_1 se développe en deux étapes, quelle que soit la vitesse V_r mise en œuvre. Par contre, à plus basse température, les points Ms et Mf associés à la transformation martensitique β_1rightarrowβ'_1 évoluent en fonction de V_r ; en particulier, ils diminuent significativement quand cette vitesse devient suffisamment élevée. D'autre part, des essais par analyse enthalpique différentielle, effectués avec V_c = V_r = 2 ^circC min^{-1} sur l'alliage à l'état trempé, ont révélé que des processus de vieillissement se développaient, entre 200 et 350 °C, dans la phase β_1 ; des précipités de très faible taille sont alors formés, qui se dissolvent ensuite partiellement lorsque le chauffage est poursuivi entre 380 et 440 °C. À température encore plus élevée (500-560 °C), la phase β_1 se décompose pour donner les phases d'équilibre α et γ_2, lesquelles à leur tour se combinent pour former la phase β stable à haute température. Par refroidissement assez lent (2 °C min^{-1}), l'alliage préalablement porté à 620 °C se retransforme en (α + γ_2) selon la réaction eutectoïde prévue par le diagramme d'équilibre.

  7. Evolution of Bacillus subtilis to enhanced hypobaric growth: global alterations in gene expression

    NASA Astrophysics Data System (ADS)

    Nicholson, Wayne; Robles-Martinez, Jose; Rivas-Castillo, Andrea; Schuerger, Andrew

    .L. (2006) Icarus, 158, 143-152. [6] Maughan, H. et al. (2006) Evolution, 60, 686-695. Acknowledgments: Thanks go to Galen Bruno, Jeff Fedenko, and José Orté ız-Lugo for excel-lent technical assistance. This work was supported by NASA grant NNX08AO15G.

  8. Reactive transport modeling of uranium 238 and radium 226 in groundwater of the Königstein uranium mine, Germany

    NASA Astrophysics Data System (ADS)

    Nitzsche, O.; Merkel, B.

    prises en compte pour obtenir des prédictions fiables concernant le transport des nucléides primaires dans les eaux souterraines. Ce papier montre la nécessité d'établir des stratégies de réhabilitation avant la fermeture de la mine d'uranium de Knigstein, près de Dresde (Allemagne). Des expériences de lessivage en colonne sur des carottes avec de l'eau enrichie en uranium fournissent des données sur le comportement de l'échange de l'uranium. La restitution de l'uranium a été observée après un lessivage par un volume supérieur à 20 fois celui des pores. Ce fort retard est dûà l'échange d'ions uranium positifs. Le code TReAC est un code de transport réactif en 1D, 2D et 3D, qui a été modifié pour prendre en compte la décroissance radioactive de l'uranium et les principaux nucléides descendants, et pour introduire l'écoulement dans un milieu à double porosité. TReAC a simulé de façon satisfaisante les courbes de restitution des expériences sur colonne et a fourni une première approche des paramètres de l'échange. L'écoulement souterrain dans la région de la mine de Knigstein a été simulé au moyen du code FLOWPATH. Le comportement du transport réactif a été simulé avec TReAC en une dimension, le long d'un axe d'écoulement long de 6000 m. Les résultats montrent que la migration de l'uranium est relativement lente ; mais du fait de la décroissance radioactive de l'uranium, la concentration en radium le long de cet axe augmente. Les résultats sont très sensibles à l'influence de l'écoulement en milieu à double porosité.

  9. Occurrence of springs in massifs of crystalline rocks, northern Portugal

    NASA Astrophysics Data System (ADS)

    Pacheco, Fernando António Leal; Alencoão, Ana Maria Pires

    2002-02-01

    croisés, les distributions des sources par ensemble de fractures ont été comparées aux situations géologiques et aux écarts liés aux différences dans les structures des roches et, probablement, aux différences dans leurs histoires de déformations. Les relations entre la fréquence des sources et la structure des roches ont été étudiées ensuite par détermination spectrale, modèle présenté dans cette étude. Les données d'entrée sont les fréquences des sources et les longueurs des fractures dans chaque domaine géologique, en plus des angles entre directions de fractures et orientation du champ de contraintes actuel (θ). La sortie du modèle donne les densités dites intrinsèques, un paramètre indexant l'existence d'une source à des facteurs tels que le type de fracture et le régime et l'âge associés de la déformation. Les densités les plus fortes (12,2 sources par km de linéament) ont été associées à des fractures jeunes produites par des déformations lentes, et les plus faibles (0,1) aux fractures anciennes ductiles et de tension. La détermination spectrale associe également chaque classe d'orientation à un paramètre structural dominant: quand la présence d'une source est contrôlée par θ, la classe est parallèle à l'orientation actuelle du champ de contrainte; lorsque le contrôle est attribué à la longueur des fractures, la présence de sources suit le plan des failles normales à grande échelle traversant la région. Resumen. Se ha llevado a cabo un inventario de manantiales emergentes de fracturas (manantiales de fracturas) en la cuenca del Río Pinhão y en el Macizo de Morais. El área estudiada ocupa unos 650 km2 y se halla al Norte de Portugal. Se ha identificado más de 1.500 manantiales, los cuales han sido asociados con dominios geológicos y conjuntos de fracturas. Mediante el Análisis de la Tabulación Cruzada, se ha comparado la distribución de los manantiales por conjuntos de fracturas entre ambientes geol

  10. Le Phénomène Wolf-Rayet au Sein des Etoiles chaudes de Populations I et II: Histoire des Vents stellaires et Impact sur la Structure nébulaire circumstellaire

    NASA Astrophysics Data System (ADS)

    Grosdidier, Yves

    2000-12-01

    -pics de BD +30 3639 suggère une anisotropie transitoire de la distribution des fragments dans le vent; (3) Le phénomène WR apparaît purement atmosphérique: la cinématique des sous-pics, les amplitudes et les échelles de temps caractéristiques des variations, ainsi que les accélérations observées sont similaires pour les deux populations. Mais, pour HD 826, une accélération maximale d'environ 70 m/s2 est détectée, valeur significativement plus importante que celles rapportées pour les autres étoiles WR pop. I & II (environ 15 m/s2). La petitesse du rayon de HD 826 en serait la cause; (4) Comme pour les WR pop. I, de grands paramètres (β supérieur ou égal à 3-10) sont requis pour ajuster les accélérations observées avec une loi de vitesse de type beta. La loi beta sous-estime systématiquement les gradients de vitesse au sein de la région de formation de la raie CIIIl5696; (5) Les vents WR pop. II étant fragmentés, l'estimation des taux de perte de masse actuels à partir de méthodes supposant les atmosphères homogènes conduit à une surestimation i) des taux de perte de masse eux-mêmes, et ii) des masses initiales des étoiles avant qu'elles n'entrent dans la phase WR. IMPACT DES VENTS: (1) Au périastre, de la poussière est détectée dans l'environnement de la binaire WC+OB WR 137. La formation de poussières est soit facilitée, soit provoquée par la collision des deux vents chauds; le rôle capital de la fragmentation des vents (fournissant une compression localisée supplémentaire du plasma) est suggéré (2) La nébuleuse M 1-67 affiche une interaction avec le milieu interstellaire (MIS) non-négligeable (``bow-shock''). Les champs de densité et de vitesse sont très perturbés. Ces perturbations sont reliées, d'une part, à l'histoire des vents issus de WR 124 durant sa propre évolution, d'autre part, à l'interaction avec le MIS. Les fonctions de structure des champs de densitéet de vitesse de M 1-67 ne révèlent aucun indice

  11. Avant-Propos

    NASA Astrophysics Data System (ADS)

    Ollivier, J.; Farhi, E.; Ferrand, M.; Benoit, M.

    2005-11-01

    solution (D. Lairez), en réflectométrie de neutrons pour l'étude de systèmes des membranes ou de protéines en interaction avec des membranes (G. Fragneto), ainsi qu'en diffraction de fibres appliquée à l'étude de l'ADN (T. Forsyth). - les simulations de dynamique moléculaire constituent une méthode théorique unique pour étudier, au niveau atomique, les mouvements internes des macromolécules biologiques, que ce soit à l'équilibre (G. Kneller, S. Crouzy) ou hors équilibre (B. Gilquin). Les trajectoires de dynamique moléculaire s'étendent aujourd'hui à la centaine de nanosecondes, et peuvent être de ce fait utilisées par certains programmes pour calculer les observables expérimentales fournies par la diffusion de neutrons (G. Kneller, T. Hinsen). - l'ouverture des neutrons à des techniques instrumentales permettant d'approcher, d'une part, des états hors-équilibre par le biais d'études cinétiques couplées à des mélanges rapides pour des études de croissance de phases (I. Grillo) ou de repliement de protéines, d'autre part, des conditions expérimentales extrèmes (hautes-pressions, M. Plazanet), nous ont semblé constituer des émergences prometteuses. À ce titre, une revue sur le repliement des protéines (V. Forge) a précisé l'importance de nombreuses techniques (fluorescence intrinsèque, dichroïsme, infra-rouge, RMN) dans le domaine, tout en permettant d'entrevoir l'intérêt des études par neutrons. - en marge des sessions purement “neutrons”, il nous semblait important de pouvoir présenter des techniques et méthodes souvent reconnues comme très complémentaires des neutrons, en privilégiant un volet “études structurales” et un volet “études dynamiques”. Côté méthodes dynamiques, la RMN (M. Blackledge) a été positionnée comme une technique permettant d'étudier la flexibilité moléculaire sur des echelles de temps plus lentes (ms). Côté méthodes structurales, la bio-cristallographie des RX appliquée à l

  12. Intrauterine growth restriction: screening, diagnosis, and management.

    PubMed

    Lausman, Andrea; Kingdom, John; Gagnon, Robert; Basso, Melanie; Bos, Hayley; Crane, Joan; Davies, Gregory; Delisle, Marie-France; Hudon, Lynda; Menticoglou, Savas; Mundle, William; Ouellet, Annie; Pressey, Tracy; Pylypjuk, Christy; Roggensack, Anne; Sanderson, Frank

    2013-08-01

    avère justifiée. (II-1) 9. Une fois mise en œuvre la surveillance d’un fœtus présentant un retard de croissance intra-utérin, les études Doppler de l’artère ombilicale et le score de profil biophysique peuvent être utilisés à titre de facteurs prédictifs à court terme du bien-être fœtal. (I) 10. En présence d’études Doppler anormales de l’artère ombilicale, une exploration approfondie du système circulatoire fœtal par examen Doppler de l’artère cérébrale moyenne, du canal d’Arantius et de la veine ombilicale peut être envisagée. (II-2) 11. Lorsque le fœtus présente un retard de croissance intra-utérin, la décision de procéder à une intervention obstétricale (y compris la césarienne, lorsque l’on constate une présentation ou une fréquence cardiaque fœtale anormale) est en grande partie fondée sur la viabilité fœtale, telle que déterminée par échographie. (II-2) 12. La mise en œuvre d’une surveillance maternelle visant l’apparition possible d’une prééclampsie est justifiée. (II-2) Recommandations 1. Les femmes devraient faire l’objet d’un dépistage visant les facteurs de risque cliniques du retard de croissance intra-utérin, et ce, au moyen d’une anamnèse exhaustive. (II-2B) 2. Les femmes devraient recevoir des conseils au sujet de l’abandon du tabagisme en tout temps au cours de la grossesse. (II-2A) 3. Les tests de dépistage de l’aneuploïdie au cours du premier et du deuxième trimestres pourraient constituer des tests utiles de la fonction placentaire. Lorsque deux résultats de test de dépistage se révèlent être anormaux, les fournisseurs de soins devraient savoir que le fœtus se trouve alors exposé à un risque accru de retard de croissance intra-utérin préterme et de mortinaissance connexe. (II-IA) 4. Lorsque la présence d’un retard de croissance intra-utérin est soupçonnée, la tenue d’autres évaluations peut contribuer à l’établissement d’un diagnostic. Lorsque cela s