Sample records for leon van speybroeck

  1. Leon Van Speybroeck Wins Astrophysics Bruno Rossi Prize

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Leon Van Speybroeck of the Harvard-Smithsonian Center for Astrophysics in Cambridge Massachusetts was awarded the 2002 Bruno Rossi Prize of the High-Energy Astrophysics Division of the American Astronomy Society. The Rossi Prize is an arnual recognition of significant contributions in high-energy astrophysics in honor of the Massachusetts Institute of Technology's late Professor Bruno Rossi, an authority on cosmic ray physics and a pioneer in the field of x-ray astronomy. Van Speybroeck, who led the effort to design and make the x-ray mirrors for NASA's premier Chandra X-Ray Observatory, was recognized for a career of stellar achievements in designing precision x-ray optics. As Telescope Scientist for Chandra, he has worked for more than 20 years with a team that includes scientists and engineers from the Harvard-Smithsonian, NASA's Marshall Space Flight Center, TRW, Inc., Huhes-Danbury (now B.F. Goodrich Aerospace), Optical Coating Laboratories, Inc., and Eastman-Kodak on all aspects of the x-ray mirror assembly that is the heart of the observatory.

  2. History of Chandra X-Ray Observatory

    NASA Image and Video Library

    2002-01-23

    Leon Van Speybroeck of the Harvard-Smithsonian Center for Astrophysics in Cambridge Massachusetts was awarded the 2002 Bruno Rossi Prize of the High-Energy Astrophysics Division of the American Astronomy Society. The Rossi Prize is an arnual recognition of significant contributions in high-energy astrophysics in honor of the Massachusetts Institute of Technology's late Professor Bruno Rossi, an authority on cosmic ray physics and a pioneer in the field of x-ray astronomy. Van Speybroeck, who led the effort to design and make the x-ray mirrors for NASA's premier Chandra X-Ray Observatory, was recognized for a career of stellar achievements in designing precision x-ray optics. As Telescope Scientist for Chandra, he has worked for more than 20 years with a team that includes scientists and engineers from the Harvard-Smithsonian, NASA's Marshall Space Flight Center, TRW, Inc., Huhes-Danbury (now B.F. Goodrich Aerospace), Optical Coating Laboratories, Inc., and Eastman-Kodak on all aspects of the x-ray mirror assembly that is the heart of the observatory.

  3. Leon X-1, the First Chandra Source

    NASA Technical Reports Server (NTRS)

    Weisskopf, Martin C.; Aldcroft, Tom; Cameron, Robert A.; Gandhi, Poshak; Foellmi, Cedric; Elsner, Ronald F.; Patel, Sandeep K.; ODell, Stephen L.

    2004-01-01

    Here we present an analysis of the first photons detected with the Chandra X-ray Observatory and an identification of the brightest source in the field which we named Leon X-1 to honor the momentous contributions of the Chandra Telescope Scientist, Leon Van Speybroeck. The observation took place immediately following the opening of the last door protecting the X-ray telescope. We discuss the unusual operational conditions as the first extra-terrestrial X-ray photons reflected from the telescope onto the ACIS camera. One bright source was a p parent to the team at the control center and the small collection of photons that appeared on the monitor were sufficient to indicate that the telescope had survived the launch and was approximately in focus, even prior to any checks and subsequent adjustments.

  4. Obituary: Leon Van Speybroeck, 1935-2002

    NASA Astrophysics Data System (ADS)

    Gorenstein, Paul; Tananbaum, Harvey Dale

    2003-12-01

    Leon Van Speybroeck, a master designer of X-ray telescope mirrors and the telescope scientist for the Chandra X-ray Observatory, died in Newton, Massachusetts, on 25 December 2002, shortly after learning that he had metastatic melanoma. Leon was born on 27 August 1935 in Wichita, Kansas. His father, Paul, was Assistant Treasurer and head of the accounting department at Beech Aircraft, and his mother, Anna Florence (Utley), was a homemaker. Both parents died in 1996. Leon's younger sister, Saundra, is a nurse and his younger brother, John, is a surgeon. Leon received a BS in 1957 and a PhD in 1965, both in physics, from MIT. His PhD thesis, ``Elastic Electron-Deuteron Scattering at High Momentum Transfer," was carried out under the supervision of Henry Kendall and Jerome Friedman. Leon spent two more years at MIT as a research associate. In 1967, he was hired by American Science and Engineering (AS&E) in Cambridge, Massachusetts, and joined the X-ray astronomy group led by Riccardo Giacconi, who received the 2002 Nobel Prize in Physics for contributions to astrophysics that led to the discovery of cosmic X-ray sources. Leon soon became involved in the design and construction of high-resolution, grazing-incidence X-ray telescopes, starting with the Apollo Telescope Mount flown on NASA's Skylab from 1973 to 1974. A series of high-resolution X-ray images of the solar corona led to dramatic changes in ideas about the solar corona, with new emphasis on magnetic dynamo processes. When the Smithsonian Astrophysical Observatory and the Harvard College Observatory morphed into the Harvard-Smithsonian Center for Astrophysics (CfA) in 1973, Leon, with Giacconi and other senior X-ray astronomers from AS&E, joined the CfA and formed the high-energy astrophysics division. Leon guided the design and development of the X-ray mirrors on NASA's Einstein Observatory, which was flown from 1978 to 1981 as the first cosmic X-ray observatory with an imaging telescope. Along the way, he helped the team to solve numerous technical challenges-for example, floating the heavy optics in a mercury bath so that their roundness could be measured without gravitational distortion. The Einstein data, which showed that virtually all classes of astronomical sources are X-ray emitters, opened the door for X-ray astronomy to join the other wavelength domains as an equally important discipline. In recognition of his accomplishments, Leon received the George W. Goddard Award in 1985 from the International Society for Optical Engineering. While the Einstein Observatory was still operating, work began on a successor with a larger effective area and substantially higher angular resolution. Leon led the technology development and then the flight program for the optics on this Advanced X-ray Astrophysics Facility (AXAF). He insisted on systematic analyses and thorough understanding of all the processing steps and metrology data. He negotiated the establishment of incentives and goals for mirror smoothness, and achieved an increase in the fraction of 6-keV X-rays encircled in a 1-arcsecond diameter from 20% to 60%. With his guidance and the efforts of many superb engineers and scientists, polishing and metrology equipment was designed, built, tested, and used at Hughes Danbury Optical Systems Inc, located in Danbury, Connecticut. The equipment was utilized to fabricate X-ray mirrors at the 0.5-arcsecond level of performance-10 times better than any previous X-ray optic. Following the successful fabrication of the optics, Leon worked with the team at Optical Coating Laboratory Inc, in Santa Rosa, California, to establish a process for depositing iridium coatings that provide a relatively high efficiency up to 10 keV and a very stable final surface. The AXAF telescope comprises four pairs of mirrors nested one inside another to increase the collecting area. A major challenge involved assembling the eight cylindrical optics into a single high-resolution telescope. Leon and the team at Eastman Kodak Company in Rochester, New York, designed a 50-foot-high vertical assembly tower that satisfied demanding environmental controls. The mirror elements were held as stress free as possible, maneuvered into alignment, and bonded into place with a slow-curing epoxy to a precision of a few tenths of an arcsecond. Following its launch aboard the space shuttle Columbia in July 1999, AXAF was renamed the Chandra X-ray Observatory. Up to the time of his death, Leon had been leading a team that used Chandra, plus microwave observations of galaxy clusters, to determine the cosmic distance scale. His colleagues expect to publish their results in late 2003. In recognition of his leadership and extraordinary contributions to Chandra, Leon received the 2002 Bruno Rossi Prize of the American Astronomical Society's high-energy astrophysics division. He died two weeks before he was scheduled to deliver his acceptance speech. Despite his illness, he had crafted a marvelous talk illustrating the tremendous advances enabled by the Chandra telescope. One of us (Tananbaum) presented his talk, which received an enthusiastic response from approximately 1000 AAS members. Leon married Erin Harrington in 1959. She survives him along with their daughter Elaine and her husband Lane Kendig; son David, his wife Jennifer Hanson, and their twin daughters Madeline and Nina; and son Alexander and his companion Sherie Davis. When not involved with X-ray telescopes or family trips to National Parks, Leon designed and built exquisite furniture in his elaborate workshop, where every tool hung neatly from its pegboard hook. On 8 February 2003 more than 200 friends and family members gathered at the Harvard Science Center for a Remembrance Service. Many smiles and more than a few tears were seen as people recalled and celebrated Leon's life. Leon was an amazing individual, respected by his colleagues as an outstanding physicist, mathematician, programmer, and engineer who could solve just about any problem. He set and met incredibly high standards in his professional and personal endeavors. He was modest about his accomplishments, but would acknowledge that ``Chandra has a pretty good mirror" when colleagues would share exciting new results made possible by his dedicated efforts and unique skills. It was a privilege to know him.

  5. Formula for the rms blur circle radius of Wolter telescope based on aberration theory

    NASA Technical Reports Server (NTRS)

    Shealy, David L.; Saha, Timo T.

    1990-01-01

    A formula for the rms blur circle for Wolter telescopes has been derived using the transverse ray aberration expressions of Saha (1985), Saha (1984), and Saha (1986). The resulting formula for the rms blur circle radius over an image plane and a formula for the surface of best focus based on third-, fifth-, and seventh-order aberration theory predict results in good agreement with exact ray tracing. It has also been shown that one of the two terms in the empirical formula of VanSpeybroeck and Chase (1972), for the rms blur circle radius of a Wolter I telescope can be justified by the aberration theory results. Numerical results are given comparing the rms blur radius and the surface of best focus vs the half-field angle computed by skew ray tracing and from analytical formulas for grazing incidence Wolter I-II telescopes and a normal incidence Cassegrain telescope.

  6. So Many Rockets - The Road to High Resolution Imaging in X-rays

    NASA Astrophysics Data System (ADS)

    Murray, Stephen S.

    2013-01-01

    When I first begin to work on new imaging detectors for X-ray Astronomy I was at AS&E and I worked with Leon Van Speybroeck and Ed Kellogg on a sounding rocket project. We starting by using a microchannel plate image intensifier to detect X-ray photons and convert them to flashes of light that were recorded on 35 mm film frames. Simultaneously there was a 16 mm star camera taking frames so we could tell where the X-rays were coming from. I spent about 6 years working on this payload, eventually becoming the PI and evolving the detector from a film readout to an electronic readout (the crossed grid charge detector) that was the basis for the Einstein, ROSAT and Chandra High Resolution Imagers and Cameras. We had a series of about 6 or so rocket flights culminating in the 1978 flight that actually worked. We detected three photons from Sco X1, and background data from that flight allowed us to set the detector front bias voltage to minimize non-X-ray background for the Einstein HRI. Just about everything that could go wrong on those rockets did go wrong, from a switch not closing to a rocket misfire, to pointing 180 degrees off target. But we learned something each flight and kept coming back to try again. The worse thing for me was having to stay up all night at White Sands in a small darkroom where I could avoid the night crawlers and scorpions that frightened me to death. Not to mention the daredevil helicopter pilots who flew us to the recovery site hugging the ground at top speed all the way there! None-the-less, in the end we succeeded in our goals, and there is nothing so exciting as watching your payload being launched at night (even it did mean sneaking out from the bunker to do it!). Thanks to NASA and the US Navy's White Sands USS Desert Ship (LLS-1; Land Locked Ship - 1) for all the support.

  7. The Smokey Hollow Community, Informal boundaries by street name: North ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    The Smokey Hollow Community, Informal boundaries by street name: North to South: East Jefferson Street to East Van Buren Street. West to East: South Gadsden Street to Marvin Street., Tallahassee, Leon County, FL

  8. Distance Education in Southern Africa Conference, 1987. Papers 4.2: Professional Education and Practical Training at a Distance.

    ERIC Educational Resources Information Center

    Adey, David, Comp.; And Others

    Fifteen papers from the University of South Africa's Conference on Distance Education are presented on professional education and practical training. They include: "The Art Work: From Concept to Realization" (Leon du Plessis and Koos van der Watt); "Distance Education for Industrial, Professional, and Practical Training" (Jacob…

  9. Advanced X-Ray Telescope Mirrors Provide Sharpest Focus Ever

    NASA Astrophysics Data System (ADS)

    1997-03-01

    Performing beyond expectations, the high- resolution mirrors for NASA's most powerful orbiting X-ray telescope have successfully completed initial testing at Marshall Space Flight Center's X-ray Calibration Facility, Huntsville, AL. "We have the first ground test images ever generated by the telescope's mirror assembly, and they are as good as -- or better than -- expected," said Dr. Martin Weisskopf, Marshall's chief scientist for NASA's Advanced X-ray Astrophysics Facility (AXAF). The mirror assembly, four pairs of precisely shaped and aligned cylindrical mirrors, will form the heart of NASA's third great observatory. The X-ray telescope produces an image by directing incoming X-rays to detectors at a focal point some 30 feet beyond the telescope's mirrors. The greater the percentage of X-rays brought to focus and the smaller the size of the focal spot, the sharper the image. Tests show that on orbit, the mirror assembly of the Advanced X-ray Astrophysics Facility will be able to focus approximately 70 percent of X-rays from a source to a spot less than one-half arc second in radius. The telescope's resolution is equivalent to being able to read the text of a newspaper from half a mile away. "The telescope's focus is very clear, very sharp," said Weisskopf. "It will be able to show us details of very distant sources that we know are out there, but haven't been able to see clearly." In comparison, previous X-ray telescopes -- Einstein and Rosat -- were only capable of focusing X- rays to five arc seconds. The Advanced X-ray Telescope's resolving power is ten times greater. "Images from the new telescope will allow us to make major advances toward understanding how exploding stars create and disperse many of the elements necessary for new solar systems and for life itself," said Dr. Harvey Tananbaum, director of the Advanced X- ray Astrophysics Facility Science Center at the Smithsonian Astrophysical Observatory, in Cambridge, MA -- responsible for the telescope's science mission. "We will observe X-rays generated when stars are torn apart by the incredibly strong gravity around massive black holes in the centers of galaxies," added Tananbaum. On a larger scale, the telescope will play a vital role in answering fundamental questions about the universe. "The superior quality of the mirrors will allow us to see and measure the details of hot gas clouds in clusters of galaxies, giving us a much better idea of the age and size of the universe," said Dr. Leon Van Speybroeck, Telescope Scientist at the Smithsonian Observatory. "These same observations also will measure the amount of dark matter present, providing unique insight into one of nature's great puzzles," said Van Speybroeck. A second phase of testing is now underway at Marshall. Calibration of the observatory's science instruments began in mid-February. "This phase of testing," said Weisskopf, "includes two focal plane instruments and two sets of gratings used to analyze images and energy distributions from cosmic sources seen by the telescope." Working around the clock, test teams are taking measurements and studying results. "It is very exciting," said Weisskopf. "With more than 1,200 measurements taken, there is already a tremendous amount of information for study." The calibration process will end around late April. The mirror assembly then will be shipped to TRW Space and Electronics Group, Redondo Beach, CA -- NASA's prime contractor for the program -- for integration into the spacecraft. The science instruments will remain at Marshall for several more weeks of testing before being shipped to Ball Aerospace and Technologies Corporation in Boulder, CO, where they will be integrated into the science instrument module before being shipped to TRW. The Advanced X-ray Astrophysics Facility is scheduled for launch in August 1998 and will join NASA's Hubble Space Telescope and Compton Gamma-ray Observatory in exploring the universe. Marshall manages development of the observatory for the Office of Space Science, NASA Headquarters, Washington, DC. Using glass purchased from Schott Glaswerke, Mainz, Germany, the telescope's mirrors were built by Hughes Danbury Optical Systems, Danbury, CT. The mirrors were coated by Optical Coating Laboratory, Inc., Santa Rosa, CA; and assembled by Eastman-Kodak Company, Rochester, NY. The AXAF CCD Imaging Spectrometer instrument was developed by Pennsylvania State University, University Park, and the Massachusetts Institute of Technology (MIT), Cambridge, MA. One of the two gratings was developed by MIT. The other was developed by the Space Research Organization Netherlands, Utrecht, Netherlands, in collaboration with the Max Planck Institute, Garching, Germany. The High Resolution Camera instrument was built by the Smithsonian Astrophysical Observatory. Note to editors: Digital images to accompany this release are available via the World Wide Web at the following URL: http://chandra.harvard.edu/press/images.html A photograph is available from the NASA Headquarters Audio Imaging Branch to news media to illustrate this story. The Photograph number is 97-HC-138. Photographs also are available from the Marshall Public Affairs office at 205/544-0034.

  10. Two-sided Topp-Leone Weibull distribution

    NASA Astrophysics Data System (ADS)

    Podeang, Krittaya; Bodhisuwan, Winai

    2017-11-01

    In this paper, we introduce a general class of lifetime distributions, called the two-sided Topp-Leone generated family of distribution. A special case of new family is the two-sided Topp-Leone Weibull distribution. This distribution used the two-sided Topp-Leone distribution as a generator for the Weibull distribution. The two-sided Topp-Leone Weibull distribution is presented in several shapes of distributions such as decreasing, unimodal, and bimodal which make this distribution more than flexible than the Weibull distribution. Its quantile function is presented. The parameter estimation method by using maximum likelihood estimation is discussed. The proposed distribution is applied to the strength data set, remission times of bladder cancer patients data set and time to failure of turbocharger data set. We compare the proposed distribution to the Topp-Leone Generated Weibull distribution. In conclusion, the two-sided Topp-Leone Weibull distribution performs similarly as the Topp-Leone Generated Weibull distribution in the first and second data sets. However, the proposed distribution can perform better than fit to Topp-Leone Generated Weibull distribution for the other.

  11. 77 FR 31372 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-25

    ... West Baxter Avenue, Knoxville, TN 37917. Leon County, Texas, and Incorporated Areas Maps Available for.... Unincorporated Areas of Leon County.... Leon County Judge's Office, 130 East St. Marys, Centerville, TX 75833...

  12. VxWorks 6.9 for LEON

    NASA Astrophysics Data System (ADS)

    Cederman, Daniel; Hellstrom, Daniel

    2016-08-01

    The VxWorks operating system together with the Cobham Grislier LEON architectural port provides an efficient platform for the development of software for space applications. It supports both uni-and multiprocessor mode (SMP or AMP) and comes with an integrated development environment with several debugging and analysis tools. The LEON architectural port from Cobham Grislier supports LEON2/3/4 systems and includes drivers for all standard on-chip peripherals, as well as support for RASTA boards. In this paper we will highlight some the many features of VxWorks and the LEON architectural port. The latest version of the architectural port now supports VxWorks 6.9 (the previous version was for VxWorks 6.7) and has the support for the GR740, the commercially available quad-core LEON system, designed as the European Space Agency's Next Generation Microprocessor (NGMP).

  13. Analysis of Security Sector Reform in Post-Conflict Sierra Leone: A Comparison of Current versus Historical Capabilities

    DTIC Science & Technology

    2010-03-01

    6 A. M. Fitz -Gerald, Security Sector Reform in Sierra Leone. Shrivenham, GFN-SSR. 8–10. Osman Gbla...34Security Sector Reform: Bringing the Private in.", 1– 23; Peter Albrecht and Paul Jackson, eds. Security System Transformation in Sierra Leone, 1997–2007...veterans.38 33 John R. Cartwright, Political leadership in Sierra Leone (Toronto: University of

  14. USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin.

    PubMed

    Wang, Chien-Hsiang; Huang, Yi-Chun; Chen, Pei-Yi; Cheng, Ying-Ju; Kao, Hsiu-Hua; Pi, Haiwei; Chien, Cheng-Ting

    2017-05-10

    Synapse formation and growth are tightly controlled processes. How synaptic growth is terminated after reaching proper size remains unclear. Here, we show that Leon, the Drosophila USP5 deubiquitinase, controls postsynaptic growth. In leon mutants, postsynaptic specializations of neuromuscular junctions are dramatically expanded, including the subsynaptic reticulum, the postsynaptic density, and the glutamate receptor cluster. Expansion of these postsynaptic features is caused by a disruption of ubiquitin homeostasis with accumulation of free ubiquitin chains and ubiquitinated substrates in the leon mutant. Accumulation of Ubiquilin (Ubqn), the ubiquitin receptor whose human homolog ubiquilin 2 is associated with familial amyotrophic lateral sclerosis, also contributes to defects in postsynaptic growth and ubiquitin homeostasis. Importantly, accumulations of postsynaptic proteins cause different aspects of postsynaptic overgrowth in leon mutants. Thus, the deubiquitinase Leon maintains ubiquitin homeostasis and proper Ubqn levels, preventing postsynaptic proteins from accumulation to confine postsynaptic growth.

  15. Exhaustion: The African Way of War

    DTIC Science & Technology

    2014-04-23

    Agony of a Nation (Freetown, Sierra Leone: Andromeda Publications, 1996), 144. 150Dorman, Blair’s Successful War, 119. 151Keen, Conflict and...Cases. Westport, CT: Praeger, 2002. Koroma, Abdul K. Sierra Leone: The Agony of a Nation. Freetown. Sierra Leone: Andromeda Publications, 1996

  16. 40 CFR 81.310 - Florida.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... County Indian River County Jackson County Jefferson County Lafayette County Lake County Lee County Leon... County Lee County Leon County Levy County Liberty County Madison County Manatee County Marion County... Indian River County Jackson County Jefferson County Lafayette County Lake County Lee County Leon County...

  17. 40 CFR 81.310 - Florida.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... County Indian River County Jackson County Jefferson County Lafayette County Lake County Lee County Leon... Lafayette County Lake County Lee County Leon County Levy County Liberty County Madison County Manatee County... Indian River County Jackson County Jefferson County Lafayette County Lake County Lee County Leon County...

  18. 78 FR 43904 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-22

    ...: Community map repository Community address Leon County, Texas, and Incorporated Areas Docket No.: FEMA-B... of Oakwood Town Hall, 135 East Broad Street, Oakwood, TX 75855. Unincorporated Areas of Leon County.... Leon County Judge's Office, 130 East St. Marys, Centerville, TX 75833. (Catalog of Federal Domestic...

  19. 78 FR 65882 - Suspension of Community Eligibility

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ..., 1982, Reg; November 20, 2013, Susp. Region VI Texas: Leon County, Unincorporated 480903 November 24, 1995, ......do Do. Areas. Emerg; N/A, Reg; November 20, 2013, Susp. Normangee, City of, Leon 480436..., Leon 480437 October 13, 1995, ......do Do. County. Emerg; N/A, Reg; November 20, 2013, Susp. Region...

  20. Curriculum Diversification Re-examined--A Case Study of Sierra Leone.

    ERIC Educational Resources Information Center

    Wright, Cream A. H.

    This paper deals with a case study of secondary curriculum diversification as a vocationalization strategy in Sierra Leone. It explores diversification issues from four crucial standpoints that are distinct but highly interrelated. First, diversification is dealt with as a policy that was adopted and actively pursued by Sierra Leone for over a…

  1. Landsat-Derived Estimates of Mangrove Extents in the Sierra Leone Coastal Landscape Complex during 1990-2016.

    PubMed

    Mondal, Pinki; Trzaska, Sylwia; de Sherbinin, Alex

    2017-12-21

    This study provides the first assessment of decadal changes in mangrove extents in Sierra Leone. While significant advances have been made in mangrove mapping using remote sensing, no study has documented long-term changes in mangrove extents in Sierra Leone-one of the most vulnerable countries in West Africa. Such understanding is critical for devising regional management strategies that can support local livelihoods. We utilize multi-date Landsat data and cloud computational techniques to quantify spatiotemporal changes in land cover, with focus on mangrove ecosystems, for 1990-2016 along the coast of Sierra Leone. We specifically focus on four estuaries-Scarcies, Sierra Leone, Yawri Bay, and Sherbro. We relied on the k-means approach for an unsupervised classification, and validated the classified map from 2016 using ground truth data collected from Sentinel-2 and high-resolution images and during field research (accuracy: 95%). Our findings indicate that the Scarcies river estuary witnessed the greatest mangrove loss since 1990 (45%), while the Sierra Leone river estuary experienced mangrove gain over the last 26 years (22%). Overall, the Sierra Leone coast lost 25% of its mangroves between 1990 and 2016, with the lowest coverage in 2000, during the period of civil war (1991-2002). However, natural mangrove dynamics, as supported by field observations, indicate the potential for regeneration and sustainability under carefully constructed management strategies.

  2. My Great Migration from Sierra Leone

    ERIC Educational Resources Information Center

    Harvard Educational Review, 2011

    2011-01-01

    This article presents the author's personal narrative as an immigrant from Sierra Leone who has undergone so many challenges in life and ended up turning all these obstacles into opportunities. In this article, the author describes his life growing up in Sierra Leone, his first experience of the horrors of war, his life as a student, and his dream…

  3. Attracting, Recruiting, and Retaining Qualified Faculty at Community Colleges in Sierra Leone

    ERIC Educational Resources Information Center

    Betts, Gloria

    2017-01-01

    This case study was designed to explore policies that were in place to attract, recruit, and retain qualified faculty for 4 community colleges in Sierra Leone. The research was necessitated by the apparent inability of Sierra Leone educators to train and retain faculty possessing the required academic credentials. The research questions were…

  4. Systematics and faunistics of Neotropical Eucosmini. 1. Chimoptesis Powell, 1964 (Lepidoptera: Tortricidae).

    PubMed

    Razowski, Ózef; Becker, Vitor Osmar

    2015-03-31

    Twenty-one new species of Chimoptesis are described and illustrated: C. costaricae (TL: Costa Rica: San José), C. phanera (TL: Mexico: Chiapas), C. rubigo (TL: Mexico: Chiapas), C. rosariana (TL: Cuba: Pinar Rio), C. miniaula (TL: Mexico: Chiapas), C. kallion (TL: Mexico: Chiapas), C. potosiana (TL: Mexico: Nuevo Leon), C. obliquaria (TL: Mexico: Nuevo Leon), C. angulata (TL: Mexico: Chiapas), C. dentitia (TL: Mexico: Chiapas), C. faceta (TL: Mexico: Nuevo Leon), C. caera (TL: Mexico: Chiapas), C. castanescens (TL: Mexico: Chiapas), C. albomixta (TL: Mexico: Distrito Federal), C. cornigera (TL: Mexico: Nuevo Leon), C. mitrion (TL: Mexico: Nuevo Leon), C. setoses (TL: Cuba: Santiago), C. juniptesis (TL: Mexico: Chiapas), C. tamaulipasia (TL: Mexico: Tamaulipas), C. zoquiapana (Mexico: Distrito Federal), and C. rufobrunnea (TL: Costa Rica: San José). Formerly known only from the U.S., Chimoptesis is recorded south to Costa Rica in Central America and Cuba in the Caribbean.

  5. Non-Governmental Organizations in Africa: The Leonenet Street Children Project in Sierra Leone

    ERIC Educational Resources Information Center

    Hinton, Samuel

    2005-01-01

    The purpose of this paper is to provide snapshots of observations, interventions, and processes in the day to day working of a child charity in Sierra Leone. There were 114 local and 49 overseas funded Non Governmental Organizations (NGOs) in Sierra Leone in 2002. The Leonenet Street Children Project was founded in 1996 by the membership of the…

  6. Assessment of Anemia Knowledge, Attitudes and Behaviors among Pregnant Women in Sierra Leone

    ERIC Educational Resources Information Center

    M'Cormack, Fredanna A. D.; Drolet, Judy C.

    2012-01-01

    Introduction: Iron deficiency anemia prevalence of pregnant Sierra Leone women currently is reported to be 59.7%. Anemia is considered to be a direct cause of 3-7% of maternal deaths and an indirect cause of 20-40% of maternal deaths. This study explores knowledge, attitudes, and behaviors of urban pregnant Sierra Leone women regarding anemia.…

  7. Ebola Virus Disease--Sierra Leone and Guinea, August 2015.

    PubMed

    Hersey, Sara; Martel, Lise D; Jambai, Amara; Keita, Sakoba; Yoti, Zabulon; Meyer, Erika; Seeman, Sara; Bennett, Sarah; Ratto, Jeffrey; Morgan, Oliver; Akyeampong, Mame Afua; Sainvil, Schabbethai; Worrell, Mary Claire; Fitter, David; Arnold, Kathryn E

    2015-09-11

    The Ebola virus disease (Ebola) outbreak in West Africa began in late 2013 in Guinea (1) and spread unchecked during early 2014. By mid-2014, it had become the first Ebola epidemic ever documented. Transmission was occurring in multiple districts of Guinea, Liberia, and Sierra Leone, and for the first time, in capital cities (2). On August 8, 2014, the World Health Organization (WHO) declared the outbreak to be a Public Health Emergency of International Concern (3). Ministries of Health, with assistance from multinational collaborators, have reduced Ebola transmission, and the number of cases is now declining. While Liberia has not reported a case since July 12, 2015, transmission has continued in Guinea and Sierra Leone, although the numbers of cases reported are at the lowest point in a year. In August 2015, Guinea and Sierra Leone reported 10 and four confirmed cases, respectively, compared with a peak of 526 (Guinea) and 1,997 (Sierra Leone) in November 2014. This report details the current situation in Guinea and Sierra Leone, outlines strategies to interrupt transmission, and highlights the need to maintain public health response capacity and vigilance for new cases at this critical time to end the outbreak.

  8. Comparison of surgical care deficiencies between US civil war hospitals and present-day hospitals in Sierra Leone.

    PubMed

    Crompton, Joseph; Kingham, T Peter; Kamara, T B; Brennan, Murray F; Kushner, Adam L

    2010-08-01

    Surgery is rapidly becoming a part of public health initiatives in developing countries. In collaboration with the Sierra Leone Ministry of Health and Sanitation, a team of local surgeons and surgeons from the organization Surgeons OverSeas (SOS) used the WHO Tool for Situational Analysis to Assess Emergency Surgical Care to quantify surgical capacity in Sierra Leone. These data were then compared to data collected from the Medical and Surgical History of the Civil War, a work documenting surgical care and hospitals during the US Civil War. There are 0.2 government hospital surgeons/100,000 people in Sierra Leone compared to 300 surgeons/100,000 soldiers in the Union Army. In Sierra Leone it is rare to have running water, fuel, anesthesia, and reliable X-rays. In comparison, US Civil War hospitals had reliable running water, fuel, and anesthesia. It is rare to manage open fractures, limb dislocations, amputations, and conditions requiring chest tubes in Sierra Leone, while these procedures were commonly employed in US Civil War hospitals. Government hospitals in present day Sierra Leone lack the infrastructure, personnel, supplies, and equipment to adequately provide emergency and essential surgical care. In a comparison of present day Sierra Leonean and US Civil War hospitals, the US Civil War facilities are equivalent and in many ways superior. It is hoped that such a comparison will aid advocacy efforts so that greater resources are devoted to improving emergency and essential surgical care in low- and middle-income countries.

  9. The Met Needs for Pediatric Surgical Conditions in Sierra Leone: Estimating the Gap.

    PubMed

    Burgos, Carmen Mesas; Bolkan, Håkon Angell; Bash-Taqi, Donald; Hagander, Lars; Von Screeb, Johan

    2018-03-01

    In low- and middle-income countries, there is a gap between the need for surgery and its equitable provision, and a lack of proxy indicators to estimate this gap. Sierra Leone is a West African country with close to three million children. It is unknown to what extent the surgical needs of these children are met. To describe a nationwide provision of pediatric surgical procedures and to assess pediatric hernia repair as a proxy indicator for the shortage of surgical care in the pediatric population in Sierra Leone. We analyzed results from a nationwide facility survey in Sierra Leone that collected data on surgical procedures from operation and anesthesia logbooks in all facilities performing surgery. We included data on all patients under the age of 16 years undergoing surgery. Primary outcomes were rate and volume of surgical procedures. We calculated the expected number of inguinal hernia in children and estimated the unmet need for hernia repair. In 2012, a total of 2381 pediatric surgical procedures were performed in Sierra Leone. The rate of pediatric surgical procedures was 84 per 100,000 children 0-15 years of age. The most common pediatric surgical procedure was hernia repair (18%), corresponding to a rate of 16 per 100,000 children 0-15 years of age. The estimated unmet need for inguinal hernia repair was 88%. The rate of pediatric surgery in Sierra Leone was very low, and inguinal hernia was the single most common procedure noted among children in Sierra Leone.

  10. 48 CFR 25.003 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Principe, Senegal, Sierra Leone, Solomon Islands, Somalia, Tanzania, Togo, Tuvalu, Uganda, Vanuatu, Yemen..., Rwanda, Samoa, Sao Tome and Principe, Senegal, Sierra Leone, Solomon Islands, Somalia, Tanzania, Togo...

  11. 48 CFR 25.003 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... and Principe, Senegal, Sierra Leone, Solomon Islands, Somalia, South Sudan, Tanzania, Timor-Leste..., Sierra Leone, Solomon Islands, Somalia, South Sudan, Tanzania, Timor-Leste, Togo, Tuvalu, Uganda, Vanuatu...

  12. 48 CFR 25.003 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., Mauritania, Mozambique, Nepal, Niger, Rwanda, Samoa, Sao Tome and Principe, Senegal, Sierra Leone, Solomon... Leone, Solomon Islands, Somalia, Tanzania, Togo, Tuvalu, Uganda, Vanuatu, Yemen, or Zambia. Least...

  13. 48 CFR 25.003 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., Mauritania, Mozambique, Nepal, Niger, Rwanda, Samoa, Sao Tome and Principe, Senegal, Sierra Leone, Solomon... Leone, Solomon Islands, Somalia, Tanzania, Togo, Tuvalu, Uganda, Vanuatu, Yemen, or Zambia. Least...

  14. The Children's War: Towards Peace in Sierra Leone. A Field Report Assessing the Protection and Assistance Needs of Sierra Leonean Children and Adolescents.

    ERIC Educational Resources Information Center

    Sommers, Marc

    Based on a 3-week field visit to Sierra Leone and Guinea, this report investigates why children (ages 0-17) have become key figures in Sierra Leone's civil war, and explores the problems that war has caused them. The report describes significant new effects of violence on three groups of Sierra Leonean children, very few of whom have received any…

  15. International Criminal Court Cases in Africa: Status and Policy Issues

    DTIC Science & Technology

    2009-07-14

    court, such as the one established for Sierra Leone.31 These courts and tribunals are distinct from the ICC. International Court of Justice The...African International Courts and Tribunals” website, at http://www.aict-cita.org. 31 The Special Court for Sierra Leone (SCSL), a hybrid international...domestic court based in Sierra Leone’s capital, Freetown, was set up jointly by the Government of Sierra Leone and the United Nations under Security

  16. 48 CFR 25.003 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., Sierra Leone, Solomon Islands, Somalia, South Sudan, Tanzania, Timor-Leste, Togo, Tuvalu, Uganda, Vanuatu..., Nepal, Niger, Rwanda, Samoa, Sao Tome and Principe, Senegal, Sierra Leone, Solomon Islands, Somalia...

  17. South African Ebola diagnostic response in Sierra Leone: A modular high biosafety field laboratory

    PubMed Central

    Jansen van Vuren, Petrus; Meier, Gunther H.; le Roux, Chantel; Conteh, Ousman S.; Kemp, Alan; Fourie, Cardia; Naidoo, Prabha; Naicker, Serisha; Ohaebosim, Phumza; Storm, Nadia; Hellferscee, Orienka; Ming Sun, Lisa K.; Mogodi, Busisiwe; Prabdial-Sing, Nishi; du Plessis, Desiree; Greyling, Deidre; Loubser, Shayne; Goosen, Mark; McCulloch, Stewart D.; Scott, Terence P.; Moerdyk, Alexandra; Dlamini, Wesley; Konneh, Kelfala; Kamara, Idrissa L.; Sowa, Dauda; Sorie, Samuel; Kargbo, Brima; Madhi, Shabir A.

    2017-01-01

    Background In August 2014, the National Institute for Communicable Diseases (NICD) in South Africa established a modular high-biosafety field Ebola diagnostic laboratory (SA FEDL) near Freetown, Sierra Leone in response to the rapidly increasing number of Ebola virus disease (EVD) cases. Methods and findings The SA FEDL operated in the Western Area of Sierra Leone, which remained a “hotspot” of the EVD epidemic for months. The FEDL was the only diagnostic capacity available to respond to the overwhelming demand for rapid EVD laboratory diagnosis for several weeks in the initial stages of the EVD crisis in the capital of Sierra Leone. Furthermore, the NICD set out to establish local capacity amongst Sierra Leonean nationals in all aspects of the FEDL functions from the outset. This led to the successful hand-over of the FEDL to the Sierra Leone Ministry of Health and Sanitation in March 2015. Between 25 August 2014 and 22 June 2016, the laboratory tested 11,250 specimens mostly from the Western Urban and Western Rural regions of Sierra Leone, of which 2,379 (21.14%) tested positive for Ebola virus RNA. Conclusions The bio-safety standards and the portability of the SA FEDL, offered a cost-effective and practical alternative for the rapid deployment of a field-operated high biocontainment facility. The SA FEDL teams demonstrated that it is highly beneficial to train the national staff in the course of formidable disease outbreak and accomplished their full integration into all operational and diagnostic aspects of the laboratory. This initiative contributed to the international efforts in bringing the EVD outbreak under control in Sierra Leone, as well as capacitating local African scientists and technologists to respond to diagnostic needs that might be required in future outbreaks of highly contagious pathogens. PMID:28628619

  18. South African Ebola diagnostic response in Sierra Leone: A modular high biosafety field laboratory.

    PubMed

    Paweska, Janusz T; Jansen van Vuren, Petrus; Meier, Gunther H; le Roux, Chantel; Conteh, Ousman S; Kemp, Alan; Fourie, Cardia; Naidoo, Prabha; Naicker, Serisha; Ohaebosim, Phumza; Storm, Nadia; Hellferscee, Orienka; Ming Sun, Lisa K; Mogodi, Busisiwe; Prabdial-Sing, Nishi; du Plessis, Desiree; Greyling, Deidre; Loubser, Shayne; Goosen, Mark; McCulloch, Stewart D; Scott, Terence P; Moerdyk, Alexandra; Dlamini, Wesley; Konneh, Kelfala; Kamara, Idrissa L; Sowa, Dauda; Sorie, Samuel; Kargbo, Brima; Madhi, Shabir A

    2017-06-01

    In August 2014, the National Institute for Communicable Diseases (NICD) in South Africa established a modular high-biosafety field Ebola diagnostic laboratory (SA FEDL) near Freetown, Sierra Leone in response to the rapidly increasing number of Ebola virus disease (EVD) cases. The SA FEDL operated in the Western Area of Sierra Leone, which remained a "hotspot" of the EVD epidemic for months. The FEDL was the only diagnostic capacity available to respond to the overwhelming demand for rapid EVD laboratory diagnosis for several weeks in the initial stages of the EVD crisis in the capital of Sierra Leone. Furthermore, the NICD set out to establish local capacity amongst Sierra Leonean nationals in all aspects of the FEDL functions from the outset. This led to the successful hand-over of the FEDL to the Sierra Leone Ministry of Health and Sanitation in March 2015. Between 25 August 2014 and 22 June 2016, the laboratory tested 11,250 specimens mostly from the Western Urban and Western Rural regions of Sierra Leone, of which 2,379 (21.14%) tested positive for Ebola virus RNA. The bio-safety standards and the portability of the SA FEDL, offered a cost-effective and practical alternative for the rapid deployment of a field-operated high biocontainment facility. The SA FEDL teams demonstrated that it is highly beneficial to train the national staff in the course of formidable disease outbreak and accomplished their full integration into all operational and diagnostic aspects of the laboratory. This initiative contributed to the international efforts in bringing the EVD outbreak under control in Sierra Leone, as well as capacitating local African scientists and technologists to respond to diagnostic needs that might be required in future outbreaks of highly contagious pathogens.

  19. Can SOF Assist USPACOM in Building a Stronger Link to China’s PLA?

    DTIC Science & Technology

    2014-05-15

    April 27, 2014. 7 Leon E . Panetta, Sustaining U.S. Global Leadership: Priorities for 21 st Century Defense (Washington DC: Office of the Secretary...9 Leon E . Panetta, Sustaining U.S. Global Leadership: Priorities for 21 st Century Defense, p. 2. 10 Ibid, pp. 1-3. 11 Chuck Hagel...20 Leon E . Panetta, Military and Security Developments Involving the People’s Republic of China 2013 (Washington DC: Office of the Secretary

  20. Landsat-Derived Estimates of Mangrove Extents in the Sierra Leone Coastal Landscape Complex during 1990–2016

    PubMed Central

    Trzaska, Sylwia

    2017-01-01

    This study provides the first assessment of decadal changes in mangrove extents in Sierra Leone. While significant advances have been made in mangrove mapping using remote sensing, no study has documented long-term changes in mangrove extents in Sierra Leone—one of the most vulnerable countries in West Africa. Such understanding is critical for devising regional management strategies that can support local livelihoods. We utilize multi-date Landsat data and cloud computational techniques to quantify spatiotemporal changes in land cover, with focus on mangrove ecosystems, for 1990–2016 along the coast of Sierra Leone. We specifically focus on four estuaries—Scarcies, Sierra Leone, Yawri Bay, and Sherbro. We relied on the k-means approach for an unsupervised classification, and validated the classified map from 2016 using ground truth data collected from Sentinel-2 and high-resolution images and during field research (accuracy: 95%). Our findings indicate that the Scarcies river estuary witnessed the greatest mangrove loss since 1990 (45%), while the Sierra Leone river estuary experienced mangrove gain over the last 26 years (22%). Overall, the Sierra Leone coast lost 25% of its mangroves between 1990 and 2016, with the lowest coverage in 2000, during the period of civil war (1991–2002). However, natural mangrove dynamics, as supported by field observations, indicate the potential for regeneration and sustainability under carefully constructed management strategies. PMID:29267247

  1. Reference-free compression of high throughput sequencing data with a probabilistic de Bruijn graph.

    PubMed

    Benoit, Gaëtan; Lemaitre, Claire; Lavenier, Dominique; Drezen, Erwan; Dayris, Thibault; Uricaru, Raluca; Rizk, Guillaume

    2015-09-14

    Data volumes generated by next-generation sequencing (NGS) technologies is now a major concern for both data storage and transmission. This triggered the need for more efficient methods than general purpose compression tools, such as the widely used gzip method. We present a novel reference-free method meant to compress data issued from high throughput sequencing technologies. Our approach, implemented in the software LEON, employs techniques derived from existing assembly principles. The method is based on a reference probabilistic de Bruijn Graph, built de novo from the set of reads and stored in a Bloom filter. Each read is encoded as a path in this graph, by memorizing an anchoring kmer and a list of bifurcations. The same probabilistic de Bruijn Graph is used to perform a lossy transformation of the quality scores, which allows to obtain higher compression rates without losing pertinent information for downstream analyses. LEON was run on various real sequencing datasets (whole genome, exome, RNA-seq or metagenomics). In all cases, LEON showed higher overall compression ratios than state-of-the-art compression software. On a C. elegans whole genome sequencing dataset, LEON divided the original file size by more than 20. LEON is an open source software, distributed under GNU affero GPL License, available for download at http://gatb.inria.fr/software/leon/.

  2. Chandra Independently Determines Hubble Constant

    NASA Astrophysics Data System (ADS)

    2006-08-01

    A critically important number that specifies the expansion rate of the Universe, the so-called Hubble constant, has been independently determined using NASA's Chandra X-ray Observatory. This new value matches recent measurements using other methods and extends their validity to greater distances, thus allowing astronomers to probe earlier epochs in the evolution of the Universe. "The reason this result is so significant is that we need the Hubble constant to tell us the size of the Universe, its age, and how much matter it contains," said Max Bonamente from the University of Alabama in Huntsville and NASA's Marshall Space Flight Center (MSFC) in Huntsville, Ala., lead author on the paper describing the results. "Astronomers absolutely need to trust this number because we use it for countless calculations." Illustration of Sunyaev-Zeldovich Effect Illustration of Sunyaev-Zeldovich Effect The Hubble constant is calculated by measuring the speed at which objects are moving away from us and dividing by their distance. Most of the previous attempts to determine the Hubble constant have involved using a multi-step, or distance ladder, approach in which the distance to nearby galaxies is used as the basis for determining greater distances. The most common approach has been to use a well-studied type of pulsating star known as a Cepheid variable, in conjunction with more distant supernovae to trace distances across the Universe. Scientists using this method and observations from the Hubble Space Telescope were able to measure the Hubble constant to within 10%. However, only independent checks would give them the confidence they desired, considering that much of our understanding of the Universe hangs in the balance. Chandra X-ray Image of MACS J1149.5+223 Chandra X-ray Image of MACS J1149.5+223 By combining X-ray data from Chandra with radio observations of galaxy clusters, the team determined the distances to 38 galaxy clusters ranging from 1.4 billion to 9.3 billion light years from Earth. These results do not rely on the traditional distance ladder. Bonamente and his colleagues find the Hubble constant to be 77 kilometers per second per megaparsec (a megaparsec is equal to 3.26 million light years), with an uncertainty of about 15%. This result agrees with the values determined using other techniques. The Hubble constant had previously been found to be 72, give or take 8, kilometers per second per megaparsec based on Hubble Space Telescope observations. The new Chandra result is important because it offers the independent confirmation that scientists have been seeking and fixes the age of the Universe between 12 and 14 billion years. Chandra X-ray Image of CL J1226.9+3332 Chandra X-ray Image of CL J1226.9+3332 "These new results are entirely independent of all previous methods of measuring the Hubble constant," said team member Marshall Joy also of MSFC. The astronomers used a phenomenon known as the Sunyaev-Zeldovich effect, where photons in the cosmic microwave background (CMB) interact with electrons in the hot gas that pervades the enormous galaxy clusters. The photons acquire energy from this interaction, which distorts the signal from the microwave background in the direction of the clusters. The magnitude of this distortion depends on the density and temperature of the hot electrons and the physical size of the cluster. Using radio telescopes to measure the distortion of the microwave background and Chandra to measure the properties of the hot gas, the physical size of the cluster can be determined. From this physical size and a simple measurement of the angle subtended by the cluster, the rules of geometry can be used to derive its distance. The Hubble constant is determined by dividing previously measured cluster speeds by these newly derived distances. Chandra X-ray Image of Abell 1689 Chandra X-ray Image of Abell 1689 This project was championed by Chandra's telescope mirror designer, Leon Van Speybroeck, who passed away in 2002. The foundation was laid when team members John Carlstrom (University of Chicago) and Marshall Joy obtained careful radio measurements of the distortions in the CMB radiation using radio telescopes at the Berkeley-Illinois-Maryland Array and the Caltech Owens Valley Radio Observatory. In order to measure the precise X-ray properties of the gas in these distant clusters, a space-based X-ray telescope with the resolution and sensitivity of Chandra was required. "It was one of Leon's goals to see this project happen, and it makes me very proud to see this come to fruition," said Chandra Project Scientist Martin Weisskopf of MSFC. The results are described in a paper appearing in the August 10th issue of The Astrophysical Journal. MSFC manages the Chandra program for the agency's Science Mission Directorate. The Smithsonian Astrophysical Observatory controls science and flight operations from the Chandra X-ray Center, Cambridge, Mass. Additional information and images can be found at: http://chandra.harvard.edu and http://chandra.nasa.gov

  3. 6. SOUTHEAST ABUTMENT AT CALVERT STREET, SHOWING LEON HERMANT ALLEGORICAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. SOUTHEAST ABUTMENT AT CALVERT STREET, SHOWING LEON HERMANT ALLEGORICAL RELIEF OF TRANSPORTATION BY AUTOMOBILE - Calvert Street Bridge, Spanning Rock Creek & Potomac Parkway, Washington, District of Columbia, DC

  4. Scaling up family planning in Sierra Leone: A prospective cost-benefit analysis.

    PubMed

    Keen, Sarah; Begum, Hashina; Friedman, Howard S; James, Chris D

    2017-12-01

    Family planning is commonly regarded as a highly cost-effective health intervention with wider social and economic benefits. Yet use of family planning services in Sierra Leone is currently low and 25.0% of married women have an unmet need for contraception. This study aims to estimate the costs and benefits of scaling up family planning in Sierra Leone. Using the OneHealth Tool, two scenarios of scaling up family planning coverage to currently married women in Sierra Leone over 2013-2035 were assessed and compared to a 'no-change' counterfactual. Our costing included direct costs of drugs, supplies and personnel time, programme costs and a share of health facility overhead costs. To monetise the benefits, we projected the cost savings of the government providing five essential social services - primary education, child immunisation, malaria prevention, maternal health services and improved drinking water - in the scale-up scenarios compared to the counterfactual. The total population, estimated at 6.1 million in 2013, is projected to reach 8.3 million by 2035 in the high scenario compared to a counterfactual of 9.6 million. We estimate that by 2035, there will be 1400 fewer maternal deaths and 700 fewer infant deaths in the high scenario compared to the counterfactual. Our modelling suggests that total costs of the family planning programme in Sierra Leone will increase from US$4.2 million in 2013 to US$10.6 million a year by 2035 in the high scenario. For every dollar spent on family planning, Sierra Leone is estimated to save US$2.10 in expenditure on the five selected social sector services over the period. There is a strong investment case for scaling up family planning services in Sierra Leone. The ambitious scale-up scenarios have historical precedent in other sub-Saharan African countries, but the extent to which they will be achieved depends on a commitment from both the government and donors to strengthening Sierra Leone's health system post-Ebola.

  5. American Society of Hand Therapists

    MedlinePlus

    ... Seychelles Sierra Leone Singapore Sint Maarten Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the ... Seychelles Sierra Leone Singapore Sint Maarten Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the ...

  6. Sierra Leone Estuary

    NASA Image and Video Library

    2014-02-05

    This image acquired by NASA Terra spacecraft is of the Sierra Leone estuary, which became a focal point for trade and interaction between Africans and Europeans because of its exceptional harbor, starting in the mid-15th century.

  7. Interagency technical consultation on improving mortality reporting in Sierra Leone: meeting report

    PubMed Central

    Asfaw, Yonas; Boateng, Isaac; Calderon, Mauricio; Caleo, Grazia; Conteh, Allan; Conteh, Salifu; Dafae, Foday; Dey, Achintya; Duffy, Nadia; Davies, Daffney; Fatoma, Patrick; Fleming, John; Gogra, Boima; Gorina, Yelena; Grigoryan, Anna; Hersey, Sara; Hoare, Sam; Jabbi, Sonnia-Magba Bu-Buakei; Jambai, Amara; Jasperse, Joseph; Kaiser, Reinhard; Kallon, Gandi; Kamara, Ansumana; Kamara, Fatmata Zara; Kamara, Isata Pamela; Kamara, Wogba; Kandeh, Joseph; Kanu, Mustapha; Kargbo, Mabinty; Kargbo, Samuel; Konie, Richard; Kuyembeh, Simeon; Lansana, Patrick; Mclysaght, Fiona; McCann, Sheena; Nallo, Alhaji Samuka; Ngai, Stephanie; Nichols, Erin; Njuguna, Charles; O-Tipo, Shikanga; Parker, Sulaiman; Rafique, Nuzhat; Redd, John; Samba, Thomas; Souza, Kerry; Tran, Alex; Younge, Chief Mathew Gibao

    2017-01-01

    By the end of the Ebola epidemic, death reporting in Sierra Leone (SL) became more acceptable amongst local populations, with nearly all deaths being reported to the Ebola hot line alert centers. To continue the positive momentum generated by the epidemic, the Sierra Leone Ministry of Health and Sanitation (MoHS) and the US Centers for Disease Control and Prevention (CDC) organized and conducted the two-day Inter-agency Consultations on Improving Mortality Reporting in Sierra Leone (Consultations). In conjunction with the Consultations, participants were also offered a one-day, in-person training on the major components, characteristics, and uses of a national Civil Registration and Vital Statistics (CRVS) system. To understand processes used by governmental and non-governmental organizations in collection of death data before and during the Ebola epidemic, and to develop recommendations on improving death reporting and CRVS in Sierra Leone. The Inter-agency Consultations were conducted in person over two days in October, 2015. Real-time notes were kept by CDC staff for later abstraction and summarizing. Presenters agreed to share their materials (usually PowerPoint presentations) and approved the summaries. Challenges to implementation and suggestions for improving death reporting were drawn from the presentations and from anonymous suggestions collected at the end of each of three days of the Consultations. The Consultations attracted more than 80 participants from 28 Sierra Leone governmental, business, and other non-governmental organizations. Over the course of 18 presentations, participants presented and discussed the ways deaths were reported before and during the Ebola epidemic and ways in which the CRVS in Sierra Leone might be improved. The presentations made clear the need to improve death reporting in order to improve the health status of Sierra Leone. Many presenters and participants discussed the challenges to improvements, including lack of infrastructure and country diversity. In addition, participants generally agreed upon the need for improving the government’s understanding of the benefits of death reporting at multiple levels: from local chiefdom authorities and councils to the community and individual families. Despite the many challenges identified, all participants stressed the need for modernizing and improving death registration in Sierra Leone. The recommendations from the presentations and notes collected at the end of each day can be categorized within the following five domains: capacity building (organizational, staffing, infrastructure, policies, guidelines and tools), awareness and sensitization (including strategies to use best practices and emerging technologies), political will (governmental support and prioritization), funding (providing resources to achieve sustainability), and monitoring and evaluation (developing charts of existing death reporting pathways and identifying challenges).

  8. First record of Tenuipalpus uvae De Leon, 1962 (Acari: Tenuipalpidae) in Brazil

    USDA-ARS?s Scientific Manuscript database

    This is the first record of Tenuipalpus uvae De Leon (Tenuipalpidae) in Brazil. Specimens were collected from Spondias mombin L. (Anacardiaceae) in the states of Amapa (Northern Brazil) and Pernambuco (northeast)....

  9. Initiatives for Sustainable Community Development in Sierra Leone.

    ERIC Educational Resources Information Center

    Kamara, John M.; Kargbo, Stephen B.

    1999-01-01

    In Sierra Leone, two church-sponsored programs are focused on sustainable development. The Wesleyan Development Education and Awareness Programme trains people to initiate community projects. Women's Loan Scheme encourages development of small-scale enterprises. (SK)

  10. 48 CFR 52.225-23 - Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act-Construction...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Principe, Senegal, Sierra Leone, Solomon Islands, Somalia, Tanzania, Togo, Tuvalu, Uganda, Vanuatu, Yemen..., Rwanda, Samoa, Sao Tome and Principe, Senegal, Sierra Leone, Solomon Islands, Somalia, Tanzania, Togo...

  11. 48 CFR 52.225-23 - Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act-Construction...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Principe, Senegal, Sierra Leone, Solomon Islands, Somalia, Tanzania, Togo, Tuvalu, Uganda, Vanuatu, Yemen..., Rwanda, Samoa, Sao Tome and Principe, Senegal, Sierra Leone, Solomon Islands, Somalia, Tanzania, Togo...

  12. 48 CFR 52.225-23 - Required Use of American Iron, Steel, and Manufactured Goods-Buy American Statute-Construction...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., Mozambique, Nepal, Niger, Rwanda, Samoa, Sao Tome and Principe, Senegal, Sierra Leone, Solomon Islands... Leone, Solomon Islands, Somalia, South Sudan, Tanzania, Timor-Leste, Togo, Tuvalu, Uganda, Vanuatu...

  13. Macroeconomic costs of the unmet burden of surgical disease in Sierra Leone: a retrospective economic analysis

    PubMed Central

    Kamara, Thaim B; Lavy, Christopher B D; Leather, Andy J M; Bolkan, Håkon A

    2018-01-01

    Objectives The Lancet Commission on Global Surgery estimated that low/middle-income countries will lose an estimated cumulative loss of US$12.3 trillion from gross domestic product (GDP) due to the unmet burden of surgical disease. However, no country-specific data currently exist. We aimed to estimate the costs to the Sierra Leone economy from death and disability which may have been averted by surgical care. Design We used estimates of total, met and unmet need from two main sources—a cluster randomised, cross-sectional, countrywide survey and a retrospective, nationwide study on surgery in Sierra Leone. We calculated estimated disability-adjusted life years from morbidity and mortality for the estimated unmet burden and modelled the likely economic impact using three different methods—gross national income per capita, lifetime earnings foregone and value of a statistical life. Results In 2012, estimated, discounted lifetime losses to the Sierra Leone economy from the unmet burden of surgical disease was between US$1.1 and US$3.8 billion, depending on the economic method used. These lifetime losses equate to between 23% and 100% of the annual GDP for Sierra Leone. 80% of economic losses were due to mortality. The incremental losses averted by scale up of surgical provision to the Lancet Commission target of 80% were calculated to be between US$360 million and US$2.9 billion. Conclusion There is a large economic loss from the unmet need for surgical care in Sierra Leone. There is an immediate need for massive investment to counteract ongoing economic losses. PMID:29540407

  14. 48 CFR 52.225-23 - Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act-Construction...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., Mozambique, Nepal, Niger, Rwanda, Samoa, Sao Tome and Principe, Senegal, Sierra Leone, Solomon Islands..., Mauritania, Mozambique, Nepal, Niger, Rwanda, Samoa, Sao Tome and Principe, Senegal, Sierra Leone, Solomon...

  15. 48 CFR 52.225-23 - Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act-Construction...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., Rwanda, Samoa, Sao Tome and Principe, Senegal, Sierra Leone, Solomon Islands, Somalia, South Sudan..., Mozambique, Nepal, Niger, Rwanda, Samoa, Sao Tome and Principe, Senegal, Sierra Leone, Solomon Islands...

  16. 76 FR 46209 - Importation of Tomatoes From the Economic Community of West African States Into the Continental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-02

    ..., Gambia, Ghana, Guinea, Guinea-Bissau, Ivory Coast, Liberia, Mali, Niger, Nigeria, Senegal, Sierra Leone..., Liberia, Mali, Niger, Nigeria, Senegal, Sierra Leone, and Togo Republic. These conditions are designed to...

  17. Symposium on Turbulent Shear Flows (8th) Held in Munich, Germany on 9-11 September 1991. Volume 2. Sessions 19-31, Poster Sessions

    DTIC Science & Technology

    1991-09-01

    FLAMES IN THE ATrR)S1]1 IERE USING A SECOND MOMNT TURBULENCE MODEL Hermilo RAMIREZ -LEON, Claude REY and Jean-Frangois SINI LABORATOIRE DE MECANIQUE DES...65 directly satisfied by an extended version of the C= F , ax6 aX5 artificial compressibility implicit method ( Ramirez -Leon et al,, 1991). 08 2 IR ap...the isotropization-of-production concept. For the compressible fluid case, Ramirez -Leon et al (1990) With regard to Eq (2), the right-hand side of

  18. A tool and index to assess surgical capacity in low income countries: an initial implementation in Sierra Leone.

    PubMed

    Groen, Reinou S; Kamara, Thaim B; Dixon-Cole, Richmond; Kwon, Steven; Kingham, T Peter; Kushner, Adam L

    2012-08-01

    A first step toward improving surgical care in many low and middle income countries is to document the need. To facilitate the collection and analysis of surgical capacity data and measure changes over time, Surgeons OverSeas (SOS) developed a tool and index based on personnel, infrastructure, procedures, equipment, and supplies (PIPES). A follow-up assessment of 10 government hospitals in Sierra Leone was completed 42 months after an initial survey in 2008 using the PIPES tool. An index based on number of operating rooms, personnel, infrastructure, procedures, equipment, and supplies was calculated. An index was also calculated, using the 2008 data for comparison. Most hospitals demonstrated an increased index that correlated with site visits that verified improved conditions. Connaught Hospital in Sierra Leone had the highest score (9.2), consistent with its being the best equipped and staffed Ministry of Health and Sanitation facility. Makeni District Hospital had the greatest increase, from 3.8 to 7.5, consistent with a newly constructed facility. The PIPES tool was easily administered at hospitals in Sierra Leone and an index was found useful. Surgical capacity in Sierra Leone improved between 2008 and 2011, as demonstrated by an increase in the overall PIPES indices.

  19. Areas Contributing Recharge to Wells in the Tafuna-Leone Plain, Tutuila, American Samoa

    USGS Publications Warehouse

    Izuka, Scot K.; Perreault, Jeff A.; Presley, Todd K.

    2007-01-01

    To address the concerns about the potential for contamination of drinking-water wells in the Tafuna-Leone Plain, Tutuila, American Samoa, a numerical ground-water flow model was developed and used to delineate areas contributing recharge to the wells (ACRWs). Surveys and analyses were conducted to obtain or compile certain essential hydrogeologic information needed for the model, such as groundwater production statistics, ground-water levels under current production, and an assessment of the distribution of groundwater recharge. The ground-water surveys indicate that total production from all wells in the Tafuna-Leone Plain between 1985 and 2005 averaged 6.1 Mgal/d and showed a gradual increase. A synoptic survey indicates that current water levels in the Tafuna-Leone Plain are highest near its inland boundary, decrease toward the coast, and are slightly depressed in high-production well fields. Ground-water levels showed little effect from the increased production because hydraulic conductivites are high and withdrawal is small relative to recharge. Analysis of ground-water recharge using a soil water-budget analysis indicates that the Tafuna-Leone Plain and adjacent areas receive about 280 Mgal/d of water from rainfall, of which 24 percent runs off to the ocean, 26 percent is removed by evapotranspiration, and 50 percent goes to ground-water recharge. Ground-water recharge per unit area is generally higher at the mountain crests than at the coast, but the highest recharge per unit area is in the mountain-front recharge zone at the juncture between the Tafuna-Leone Plain and the adjacent mountains. Surface water from the mountains also contributes to ground-water recharge in the eastern Tafuna-Leone Plain, in a process analogous to mountain-front recharge described in arid areas. Analysis of stream-gage data indicates that in the mountains of Tutuila, ground water discharges and contributes substantially to the total flow of the streams. In contrast, multiple lines of evidence indicate that in the eastern Tafuna-Leone Plain, surface water recharges the highly permeable underlying aquifer. Steady-state model simulations representing current ground-water production conditions in the Tafuna-Leone Plain indicate that most ACRWs extend less than a mile from the production wells; thus, travel distance between any point within an ACRW and its well is short. A simulation representing a condition in which all wells are operating at maximum capacity resulted in larger ACRWs, which demonstrates that increasing ground-water withdrawal from existing wells, or building and developing new wells, increases the surface area that could potentially contribute contaminants. In some places, such as in Malaeimi Valley, water can travel quickly via surface-water routes to an area where the water can infiltrate within the ACRWs of a well field.

  20. 77 FR 63314 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... (E. Ann Worthy, Vice President) 2200 North Pearl Street, Dallas, Texas 75201-2272: 1. James Leon... Irrevocable Trust; Diana McBay Bradley, James Leon Bradley, Jr.; and Christopher Richard Bradley, all of...

  1. RTEMS SMP and MTAPI for Efficient Multi-Core Space Applications on LEON3/LEON4 Processors

    NASA Astrophysics Data System (ADS)

    Cederman, Daniel; Hellstrom, Daniel; Sherrill, Joel; Bloom, Gedare; Patte, Mathieu; Zulianello, Marco

    2015-09-01

    This paper presents the final result of an European Space Agency (ESA) activity aimed at improving the software support for LEON processors used in SMP configurations. One of the benefits of using a multicore system in a SMP configuration is that in many instances it is possible to better utilize the available processing resources by load balancing between cores. This however comes with the cost of having to synchronize operations between cores, leading to increased complexity. While in an AMP system one can use multiple instances of operating systems that are only uni-processor capable, a SMP system requires the operating system to be written to support multicore systems. In this activity we have improved and extended the SMP support of the RTEMS real-time operating system and ensured that it fully supports the multicore capable LEON processors. The targeted hardware in the activity has been the GR712RC, a dual-core core LEON3FT processor, and the functional prototype of ESA's Next Generation Multiprocessor (NGMP), a quad core LEON4 processor. The final version of the NGMP is now available as a product under the name GR740. An implementation of the Multicore Task Management API (MTAPI) has been developed as part of this activity to aid in the parallelization of applications for RTEMS SMP. It allows for simplified development of parallel applications using the task-based programming model. An existing space application, the Gaia Video Processing Unit, has been ported to RTEMS SMP using the MTAPI implementation to demonstrate the feasibility and usefulness of multicore processors for space payload software. The activity is funded by ESA under contract 4000108560/13/NL/JK. Gedare Bloom is supported in part by NSF CNS-0934725.

  2. Lassa fever in post-conflict sierra leone.

    PubMed

    Shaffer, Jeffrey G; Grant, Donald S; Schieffelin, John S; Boisen, Matt L; Goba, Augustine; Hartnett, Jessica N; Levy, Danielle C; Yenni, Rachael E; Moses, Lina M; Fullah, Mohammed; Momoh, Mambo; Fonnie, Mbalu; Fonnie, Richard; Kanneh, Lansana; Koroma, Veronica J; Kargbo, Kandeh; Ottomassathien, Darin; Muncy, Ivana J; Jones, Abigail B; Illick, Megan M; Kulakosky, Peter C; Haislip, Allyson M; Bishop, Christopher M; Elliot, Deborah H; Brown, Bethany L; Zhu, Hu; Hastie, Kathryn M; Andersen, Kristian G; Gire, Stephen K; Tabrizi, Shervin; Tariyal, Ridhi; Stremlau, Mathew; Matschiner, Alex; Sampey, Darryl B; Spence, Jennifer S; Cross, Robert W; Geisbert, Joan B; Folarin, Onikepe A; Happi, Christian T; Pitts, Kelly R; Geske, F Jon; Geisbert, Thomas W; Saphire, Erica Ollmann; Robinson, James E; Wilson, Russell B; Sabeti, Pardis C; Henderson, Lee A; Khan, S Humarr; Bausch, Daniel G; Branco, Luis M; Garry, Robert F

    2014-03-01

    Lassa fever (LF), an often-fatal hemorrhagic disease caused by Lassa virus (LASV), is a major public health threat in West Africa. When the violent civil conflict in Sierra Leone (1991 to 2002) ended, an international consortium assisted in restoration of the LF program at Kenema Government Hospital (KGH) in an area with the world's highest incidence of the disease. Clinical and laboratory records of patients presenting to the KGH Lassa Ward in the post-conflict period were organized electronically. Recombinant antigen-based LF immunoassays were used to assess LASV antigenemia and LASV-specific antibodies in patients who met criteria for suspected LF. KGH has been reestablished as a center for LF treatment and research, with over 500 suspected cases now presenting yearly. Higher case fatality rates (CFRs) in LF patients were observed compared to studies conducted prior to the civil conflict. Different criteria for defining LF stages and differences in sensitivity of assays likely account for these differences. The highest incidence of LF in Sierra Leone was observed during the dry season. LF cases were observed in ten of Sierra Leone's thirteen districts, with numerous cases from outside the traditional endemic zone. Deaths in patients presenting with LASV antigenemia were skewed towards individuals less than 29 years of age. Women self-reporting as pregnant were significantly overrepresented among LASV antigenemic patients. The CFR of ribavirin-treated patients presenting early in acute infection was lower than in untreated subjects. Lassa fever remains a major public health threat in Sierra Leone. Outreach activities should expand because LF may be more widespread in Sierra Leone than previously recognized. Enhanced case finding to ensure rapid diagnosis and treatment is imperative to reduce mortality. Even with ribavirin treatment, there was a high rate of fatalities underscoring the need to develop more effective and/or supplemental treatments for LF.

  3. Macroeconomic costs of the unmet burden of surgical disease in Sierra Leone: a retrospective economic analysis.

    PubMed

    Grimes, Caris E; Quaife, Matthew; Kamara, Thaim B; Lavy, Christopher B D; Leather, Andy J M; Bolkan, Håkon A

    2018-03-14

    The Lancet Commission on Global Surgery estimated that low/middle-income countries will lose an estimated cumulative loss of US$12.3 trillion from gross domestic product (GDP) due to the unmet burden of surgical disease. However, no country-specific data currently exist. We aimed to estimate the costs to the Sierra Leone economy from death and disability which may have been averted by surgical care. We used estimates of total, met and unmet need from two main sources-a cluster randomised, cross-sectional, countrywide survey and a retrospective, nationwide study on surgery in Sierra Leone. We calculated estimated disability-adjusted life years from morbidity and mortality for the estimated unmet burden and modelled the likely economic impact using three different methods-gross national income per capita, lifetime earnings foregone and value of a statistical life. In 2012, estimated, discounted lifetime losses to the Sierra Leone economy from the unmet burden of surgical disease was between US$1.1 and US$3.8 billion, depending on the economic method used. These lifetime losses equate to between 23% and 100% of the annual GDP for Sierra Leone. 80% of economic losses were due to mortality. The incremental losses averted by scale up of surgical provision to the Lancet Commission target of 80% were calculated to be between US$360 million and US$2.9 billion. There is a large economic loss from the unmet need for surgical care in Sierra Leone. There is an immediate need for massive investment to counteract ongoing economic losses. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  4. Manure nutrient management effects in the Leon River Watershed

    USDA-ARS?s Scientific Manuscript database

    The Leon River Watershed (LRW) in central Texas is a Benchmark and Special Emphasis watershed within the Conservation Effects Assessment Project (CEAP) located in central Texas. Model simulations from 1977 through 2006 were used to evaluate six manure nutrient management scenarios that reflect reali...

  5. Comparison of social resistance to Ebola response in Sierra Leone and Guinea suggests explanations lie in political configurations not culture

    PubMed Central

    Wilkinson, Annie; Fairhead, James

    2017-01-01

    Abstract Sierra Leone and Guinea share broadly similar cultural worlds, straddling the societies of the Upper Guinea Coast with Islamic West Africa. There was, however, a notable difference in their reactions to the Ebola epidemic. As the epidemic spread in Guinea, acts of violent or everyday resistance to outbreak control measures repeatedly followed, undermining public health attempts to contain the crisis. In Sierra Leone, defiant resistance was rarer. Instead of looking to ‘culture’ to explain patterns of social resistance (as was common in the media and in the discourse of responding public health authorities) a comparison between Sierra Leone and Guinea suggests that explanations lie in divergent political practice and lived experiences of the state. In particular the structures of state authority through which the national epidemic response were organised integrated very differently with trusted institutions in each country. Predicting and addressing social responses to epidemic control measures should assess such political-trust configurations when planning interventions. PMID:28366999

  6. Trends in Lung Cancer Incidence in a Healthcare Area.

    PubMed

    Molina, Antonio J; García-Martínez, Lidia; Zapata-Alvarado, Julio; Alonso-Orcajo, Nieves; Fernández-Villa, Tania; Martín, Vicente

    2015-11-01

    The aim of this study was to identify trends in the incidence of lung cancer in the Leon Healthcare Area. All cases of cancer among residents of the Leon healthcare catchment area listed in the hospital-based tumor registry of the Centro Asistencial Universitario de Leon (CAULE) between 1996 and 2010 were included. Gross incidence rates over 3-year intervals were calculated and adjusted for the worldwide and European populations. A total of 2,491 cases were included. In men, incidence adjusted for the European population rose from 40.1 new cases per 100,000 population (1996-1998) to 61.8 (2005-2007), and then fell to 54.6 (2008-2010). In women, incidence tripled from 3.0 (1996-1998) to 9.2 new cases per 100,000 (2008-2010). Although lung cancer is an avoidable disease, it is a serious problem in the Leon Healthcare Area. Of particular concern is the rising incidence among women. Copyright © 2015 SEPAR. Published by Elsevier Espana. All rights reserved.

  7. Utilization of respondent-driven sampling among a population of child workers in the diamond-mining sector of Sierra Leone.

    PubMed

    Bjørkhaug, I; Hatløy, A

    2009-01-01

    This article describes the implementation of respondent driven sampling (RDS) in a study conducted in Kono District, Sierra Leone. RDS was used to identify children, under the age of 18 years old, working in the diamond sector of Sierra Leone. This includes children working directly as diamond miners as well as children working in the informal sector connected to the diamond field. The article seeks to postulate that RDS is a suitable method for a rapid approach to a population that is unidentified in size and demonstrate how RDS can reach a study population within a limited period.

  8. Interviews with Exemplary Teachers: Leon F. Litwack.

    ERIC Educational Resources Information Center

    Rosenzweig, Roy

    2001-01-01

    Presents an interview with Leon F. Litwack, a professor of U.S. history at the University of California, Berkeley. Covers topics such as what led him to teaching history, his lectures at Berkeley, themes covered in his U.S. history surveys, and his perception of good teaching. (CMK)

  9. Military Interventions in Sierra Leone: Lessons from a Failed State

    DTIC Science & Technology

    2008-01-01

    enslaved from Sierra Leone were shipped to the Caribbean and Brazil . This heinous trade lasted for over 100 years. Competing religious...Bana. Map 6. Operation BARRAS area of operations. 67 Magbeni and Gberi Bana were surrounded by dense jungle vegeta­ tion, mangrove swamps, murky

  10. Developmental Differences in Motor Task Integration: A Test of Pascual-Leone's Theory of Constructive Operators.

    ERIC Educational Resources Information Center

    Todor, John I.

    1979-01-01

    Assesses the ability of Pascual-Leone's Theory of Constructive Operators to predict the minimum age or maturational level at which integration of a motor task could be achieved. Subjects were 114 elementary school children ranging in age from 5 to 12. (Author/MP)

  11. 78 FR 65302 - Notice of Public Meetings for the Draft Environmental Impact Statement/Overseas Environmental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-31

    ... of Guam, Leon Guerrero School of Business and Public Administration Building, Anthony Leon Guerrero... DEPARTMENT OF DEFENSE Department of the Navy Notice of Public Meetings for the Draft Environmental... Islands Training and Testing Study Area; Correction and Public Comment Period Extension AGENCY: Department...

  12. 77 FR 4380 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ... POSTAL REGULATORY COMMISSION [Docket No. A2012-114; Order No. 1157] Post Office Closing AGENCY... the closing of the Ponce de Leon, Missouri post office has been filed. It identifies preliminary steps... petition for review of the Postal Service's determination to close the Ponce de Leon Post Office in Ponce...

  13. Susu Language Manual: Sierra Leone.

    ERIC Educational Resources Information Center

    Peace Corps, Freetown (Sierra Leone).

    A teacher's guide for Susu is designed for Peace Corps volunteer language instruction and geared to the daily language needs of volunteers in Sierra Leone. It contains a section on Susu phonology and 28 lessons on these topics: situation-specific greetings, basic greetings, introducing a friend, the market, travel and getting directions, visiting…

  14. Leon Cooper's Perspective on Teaching Science: An Interview Study

    ERIC Educational Resources Information Center

    Niaz, Mansoor; Klassen, Stephen; McMillan, Barbara; Metz, Don

    2010-01-01

    The authors of this paper portray the perspective of Professor Leon Cooper, a theoretical physicist, Nobel laureate, active researcher, and physics textbook author, on teaching science and on the nature of science (NOS). The views presented emerged from an interview prepared by the authors and responded to in writing by Professor Cooper. Based on…

  15. Home Alone: Children as Caretakers in Leon, Nicaragua

    ERIC Educational Resources Information Center

    Dahlblom, Kjerstin; Herrara, Andres Rodriguez; Pena, Rodolfo; Dahlgren, Lars

    2009-01-01

    This article seeks to explore and understand the life situations of sibling caretakers in poor areas in Leon, Nicaragua. The every day lives for caretakers were studied through observations and interviews with children, informants and parents. The children themselves were satisfied and proud to be trusted as caretakers and felt useful in…

  16. Training for Innovation: Capacity-Building in Agricultural Research in Post-War Sierra Leone

    ERIC Educational Resources Information Center

    Gboku, Matthew L. S.; Bebeley, Jenneh F.

    2016-01-01

    This paper examines how the Sierra Leone Agricultural Research Institute (SLARI) used training and development to build capacity for innovation in agricultural research following the country's civil war which ended in 2002. The Institute's training for innovation addressed different agricultural product value chains (APVCs) within the framework of…

  17. Fermilab Science Education Office - Educators/Teachers

    Science.gov Websites

    - FAQ - Fermilab Friends - Fermilab Home Fermilab Office of Education & Public Outreach Fermilab MS Prairie Exhibits Leon M. Lederman Science Adventures Teacher Resource Center The Leon M. Lederman Science Education Center houses hands-on exhibits for ages 10+, technology and science labs, a store and the K-12

  18. The Great War and Remembrance in Jose Leon Machado's "Memoria das Estrelas sem Brilho"

    ERIC Educational Resources Information Center

    Azevedo, Milton M.

    2011-01-01

    This article analyzes Jose Leon Machado's novel, "Memoria das Estrelas sem Brilho," as a multilayered historical novel in which a war story provides a background for comments on aspects of early twentieth-century Portuguese society, such as male bonding, religion, sexual mores, and social stratification. (Contains 11 notes.)

  19. Food Deserts in Leon County, FL: Disparate Distribution of Supplemental Nutrition Assistance Program-Accepting Stores by Neighborhood Characteristics

    ERIC Educational Resources Information Center

    Rigby, Samantha; Leone, Angela F.; Kim, Hwahwan; Betterley, Connie; Johnson, Mary Ann; Kurtz, Hilda; Lee, Jung Sun

    2012-01-01

    Objective: Examine whether neighborhood characteristics of racial composition, income, and rurality were related to distribution of Supplemental Nutrition Assistance Program (SNAP)-accepting stores in Leon County, Florida. Design: Cross-sectional; neighborhood and food store data collected in 2008. Setting and Participants: Forty-eight census…

  20. Phylogenetic analysis of West Nile virus, Nuevo Leon State, Mexico.

    PubMed

    Blitvich, Bradley J; Fernández-Salas, Ildefonso; Contreras-Cordero, Juan F; Loroño-Pino, María A; Marlenee, Nicole L; Díaz, Francisco J; González-Rojas, José I; Obregón-Martínez, Nelson; Chiu-García, Jorge A; Black, William C; Beaty, Barry J

    2004-07-01

    West Nile virus RNA was detected in brain tissue from a horse that died in June 2003 in Nuevo Leon State, Mexico. Nucleotide sequencing and phylogenetic analysis of the premembrane and envelope genes showed that the virus was most closely related to West Nile virus isolates collected in Texas in 2002.

  1. Phylogenetic Analysis of West Nile Virus, Nuevo Leon State, Mexico

    PubMed Central

    Blitvich, Bradley J.; Fernández-Salas, Ildefonso; Contreras-Cordero, Juan F.; Loroño-Pino, María A.; Marlenee, Nicole L.; Díaz, Francisco J.; González-Rojas, José I.; Obregón-Martínez, Nelson; Chiu-García, Jorge A.; Black, William C.

    2004-01-01

    West Nile virus RNA was detected in brain tissue from a horse that died in June 2003 in Nuevo Leon State, Mexico. Nucleotide sequencing and phylogenetic analysis of the premembrane and envelope genes showed that the virus was most closely related to West Nile virus isolates collected in Texas in 2002. PMID:15324558

  2. The Auto-Bäcklund transformations for the (2+1)-dimensional Boiti-Leon-Manna-Pempinelli equation

    NASA Astrophysics Data System (ADS)

    Kaplan, Melike; Akbulut, Arzu; Bekir, Ahmet

    2017-01-01

    In this work, the homogeneous balance method is used to construct Auto-Bäcklund transformation of the Boiti-Leon-Manna-Pempinelli (BLMP) equation. With the aid of the transformations founded in this paper and Maple packet programme, abundant exact and explicit solutions to the BLMP equation are constructed.

  3. GT-10 - EARTH SKY - COAHUILA & NUEVO LEON, MEXICO

    NASA Image and Video Library

    1966-07-18

    S66-45763 (18-21 July 1966) --- Don Martin Reservoir and Sabinas River Valley area of the States of Coahuila and Nuevo Leon, Mexico, as seen from the Gemini-10 spacecraft. Taken with a J. A. Maurer 70mm camera, using Eastman Kodak, Ektachrome, MS (S.O. 217) color film. Photo credit: NASA

  4. Youth Reintegration Training and Education for Peace (YRTEP) Program: Sierra Leone, 2000-2001. Impact Evaluation.

    ERIC Educational Resources Information Center

    Fauth, Gloria; Daniels, Bonnie

    Management Systems International (MSI), with funding from United States Agency for International Development Office of Transition Initiatives (USAID/OTI) and in coordination with other partners, is implementing a program in Sierra Leone entitled "Youth Reintegration Training and Education for Peace" (YRTEP). The object is to provide…

  5. Power in Practice: Trade Union Education in Sierra Leone

    ERIC Educational Resources Information Center

    Stirling, John

    2013-01-01

    This article presents an analysis of the development of a trade union education program in Sierra Leone in the geo-historical context of British colonialism. It places the argument in relation to the contradictory trends of trade unionism more generally and alongside their antagonistic cooperation with capitalism. It discusses the limits and…

  6. Linking Research, Extension and Farmers: The Case of Mangrove Swamp Rice Cultivation in Sierra Leone.

    ERIC Educational Resources Information Center

    Zinnah, Moses Moroe

    1994-01-01

    Interviews with 124 rice farmers in Sierra Leone revealed that farmers and extension staff have minimal participation and input in testing of new cultivation technologies. The top-down research approach has limited contact among researchers, extension staff, and farmers and affected the utility and application of research. (SK)

  7. Why High School Must Go: An Interview with Leon Botstein

    ERIC Educational Resources Information Center

    Epstein, Robert

    2007-01-01

    This article presents an interview with Leon Botstein, longtime president of Bard College, as well as music director and conductor of the American and Jerusalem symphony orchestras. Botstein talks about his book entitled "Jefferson's Children: Education and the Promise of American Culture" and his views about teens and high schools in America.…

  8. A previously undiscovered group of chimpanzees (Pan troglodytes verus) is observed living in the Tonkolili district of Sierra Leone.

    PubMed

    Halloran, Andrew R; Cloutier, Christina T; Sesay, Papanie Bai

    2013-06-01

    A previously undocumented group of wild chimpanzees (Pan troglodytes verus) was recently discovered along the Pampana River in the Tonkolili District of Sierra Leone. Based on interviews from local residents (N = 6), we estimate the group size to be approximately 30 individuals. Though this population does not show up in the most recent census of chimpanzees in Sierra Leone, it concurs with findings that indicate most of the chimpanzees in Sierra Leone live scattered throughout the country alongside villages, rather than in protected areas. During a three-week observation in the area, two chimpanzees were hunted and killed. The reason for these deaths, along with other reported instances of hunting in the area, are primarily due to crop-raiding and competition for resources between chimpanzees and humans. We conclude that this is a heavily imperiled population. Based on the ecology of the area and composition of local villages, we propose a number of conservation strategies that will promote a symbiotic relationship between the chimpanzees and human populations residing in the area. © 2013 Wiley Periodicals, Inc.

  9. Swimming with the Shoal

    NASA Astrophysics Data System (ADS)

    Childs, Ann

    2017-10-01

    This article responds to Yuli Rahmawati and Peter Charles Taylor's piece and explores my role as a science teacher, science teacher educator and researcher in two contexts, Sierra Leone and Bhutan. In the first part of the article I reflect on my 3 years as a science teacher in Sierra Leone and demonstrate resonances with Yuli's accounts of culture shock and with her positioning of herself in a third space. I also reflect on the importance of colleagues in helping me reshape my identity as a science teacher in this new context. The second part of the article reflects on much shorter periods of time in Bhutan and my work as a teacher educator and researcher where, unlike Sierra Leone, it was not possible because of the short periods I worked there, to occupy a third space. I close by discussing how in Bhutan, but also Sierra Leone, collaboration with colleagues allowed me to contribute my own expertise, despite my lack of a deep understanding of the cultural context, in a way that was as valuable as possible. I liken this way of collaborative working in my professional life as `swimming with the shoal'.

  10. Analysis of water-surface profiles in Leon County and the city of Tallahassee, Florida

    USGS Publications Warehouse

    Franklin, M.A.; Orr, R.A.

    1987-01-01

    Water surface profiles for the 10-, 25-, 50-, and 100-yr recurrence interval floods for most of the streams that drain developing areas of Leon County and the city of Tallahassee are presented. The principal streams studied are in the Lake Munson, Lake Lafayette, and Lake Jackson basins Peak discharges were computed from regression equations based on information gained from 15 streamflow stations in the area. Standard step-backwater procedures were used to determine the water-surface elevations for the streams. The flood elevations were generally higher than those in the Flood Insurance Studies for Tallahassee (1976) and Leon County (1982). The primary reason for the higher profiles is that peak discharges used in this report are larger than those used previously, largely due to changes in land use. The flood profiles for Bradford Brook, North Branch Gum Creek, and West Branch Gum Creek generally match those in the Leon County Flood Insurance Studies. Channel improvements in some areas would lower the flood elevation in that area, but would probably increase flooding downstream. (Lantz-PTT)

  11. Good laboratory practices guarantee biosafety in the Sierra Leone-China friendship biosafety laboratory.

    PubMed

    Wang, Qin; Zhou, Wei-Min; Zhang, Yong; Wang, Huan-Yu; Du, Hai-Jun; Nie, Kai; Song, Jing-Dong; Xiao, Kang; Lei, Wen-Wen; Guo, Jian-Qiang; Wei, He-Jiang; Cai, Kun; Wang, Yan-Hai; Wu, Jiang; Kamara, Gerard; Kamara, Idrissa; Wei, Qiang; Liang, Mi-Fang; Wu, Gui-Zhen; Dong, Xiao-Ping

    2016-06-23

    The outbreak of Ebola virus disease (EVD) in West Africa between 2014 and 2015 was the largest EDV epidemic since the identification of Ebola virus (EBOV) in 1976, and the countries most strongly affected were Sierra Leone, Guinea, and Liberia. The Sierra Leone-China Friendship Biological Safety Laboratory (SLE-CHN Biosafety Lab), a fixed Biosafety Level 3 laboratory in the capital city of Sierra Leone, was established by the Chinese government and has been active in EBOV detection since 11 March 2015. Complete management and program documents were created for the SLE-CHN Biosafety Lab, and it was divided into four zones (the green, yellow, brown, and red zones) based on the risk assessment. Different types of safe and appropriate personnel protection equipment (PPE) are used in different zones of the laboratory, and it fully meets the Biosafety Level 3 laboratory standards of the World Health Organization. Good preparedness, comprehensive risk assessment and operation documents, appropriate PPE, effective monitoring and intensive training, together with well-designed and reasonable laboratory sectioning are essential for guaranteeing biosafety.

  12. Individual and community perceptions of surgical care in Sierra Leone.

    PubMed

    Groen, Reinou S; Sriram, Veena M; Kamara, Thaim B; Kushner, Adam L; Blok, Lucie

    2014-01-01

    To determine themes and beliefs that influence health-seeking behaviour and barriers to accessing surgical care. In January 2012 in Western Area Province of Sierra Leone, six Focus Group Discussions (FGDs) were conducted. The FDGs consisted of three male only and three female only groups in an urban, a slum and a rural setting. Researchers investigated a wide range of topics including definitions of surgery, types of surgical procedures, trust, quality of care, human resources, post-operative care, permission-seeking and traditional beliefs. Although many individual beliefs were expressed, common fears were as follows: becoming half human after surgery; complications from procedures; stigma from having a scar; and financial burdens resulting from the cost of care. Participants also expressed concern about the quality of the care available in Sierra Leone. The concept of being half human after surgery, previously not documented in the literature, is noteworthy and should be explored more fully. Qualitative research in other parts of Sierra Leone and other LMICs into beliefs of the local population could improve programmes for access and delivery of surgical care. © 2013 John Wiley & Sons Ltd.

  13. When free healthcare is not free. Corruption and mistrust in Sierra Leone's primary healthcare system immediately prior to the Ebola outbreak.

    PubMed

    Pieterse, Pieternella; Lodge, Tom

    2015-11-01

    Sierra Leone is one of three countries recently affected by Ebola. In debates surrounding the circumstances that contributed to the initial failure to contain the outbreak, the word 'trust' is often used: In December 2014, WHO director Margret Chan used 'lack of trust in governments'; The Lancet's Editor-in-Chief, wrote how Ebola has exposed the '… breakdown of trust between communities and their governments.' This article explores the lack of trust in public healthcare providers in Sierra Leone, predating the Ebola outbreak, apparently linked to widespread petty corruption in primary healthcare facilities. It compares four NGO-supported accountability interventions targeting Sierra Leone's primary health sector. Field research was conducted in Kailahun, Kono and Tonkolili Districts, based on interviews with health workers and focus group discussions with primary healthcare users. Field research showed that in most clinics, women and children entitled to free care routinely paid for health services. A lack of accountability in Sierra Leone's health sector appears pervasive at all levels. Petty corruption is rife. Understaffing leads to charging for free care in order to pay clinic-based 'volunteers' who function as vaccinators, health workers and birth attendants. Accountability interventions were found to have little impact on healthworker (mis)behaviour. © The Author 2015. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  14. Lassa Fever in Post-Conflict Sierra Leone

    PubMed Central

    Hartnett, Jessica N.; Levy, Danielle C.; Yenni, Rachael E.; Moses, Lina M.; Fullah, Mohammed; Momoh, Mambo; Fonnie, Mbalu; Fonnie, Richard; Kanneh, Lansana; Koroma, Veronica J.; Kargbo, Kandeh; Ottomassathien, Darin; Muncy, Ivana J.; Jones, Abigail B.; Illick, Megan M.; Kulakosky, Peter C.; Haislip, Allyson M.; Bishop, Christopher M.; Elliot, Deborah H.; Brown, Bethany L.; Zhu, Hu; Hastie, Kathryn M.; Andersen, Kristian G.; Gire, Stephen K.; Tabrizi, Shervin; Tariyal, Ridhi; Stremlau, Mathew; Matschiner, Alex; Sampey, Darryl B.; Spence, Jennifer S.; Cross, Robert W.; Geisbert, Joan B.; Folarin, Onikepe A.; Happi, Christian T.; Pitts, Kelly R.; Geske, F. Jon; Geisbert, Thomas W.; Saphire, Erica Ollmann; Robinson, James E.; Wilson, Russell B.; Sabeti, Pardis C.; Henderson, Lee A.; Khan, S. Humarr; Bausch, Daniel G.; Branco, Luis M.; Garry, Robert F.

    2014-01-01

    Background Lassa fever (LF), an often-fatal hemorrhagic disease caused by Lassa virus (LASV), is a major public health threat in West Africa. When the violent civil conflict in Sierra Leone (1991 to 2002) ended, an international consortium assisted in restoration of the LF program at Kenema Government Hospital (KGH) in an area with the world's highest incidence of the disease. Methodology/Principal Findings Clinical and laboratory records of patients presenting to the KGH Lassa Ward in the post-conflict period were organized electronically. Recombinant antigen-based LF immunoassays were used to assess LASV antigenemia and LASV-specific antibodies in patients who met criteria for suspected LF. KGH has been reestablished as a center for LF treatment and research, with over 500 suspected cases now presenting yearly. Higher case fatality rates (CFRs) in LF patients were observed compared to studies conducted prior to the civil conflict. Different criteria for defining LF stages and differences in sensitivity of assays likely account for these differences. The highest incidence of LF in Sierra Leone was observed during the dry season. LF cases were observed in ten of Sierra Leone's thirteen districts, with numerous cases from outside the traditional endemic zone. Deaths in patients presenting with LASV antigenemia were skewed towards individuals less than 29 years of age. Women self-reporting as pregnant were significantly overrepresented among LASV antigenemic patients. The CFR of ribavirin-treated patients presenting early in acute infection was lower than in untreated subjects. Conclusions/Significance Lassa fever remains a major public health threat in Sierra Leone. Outreach activities should expand because LF may be more widespread in Sierra Leone than previously recognized. Enhanced case finding to ensure rapid diagnosis and treatment is imperative to reduce mortality. Even with ribavirin treatment, there was a high rate of fatalities underscoring the need to develop more effective and/or supplemental treatments for LF. PMID:24651047

  15. Hydrology, Water Quality, and Aquatic Communities of Selected Springs in the St. Johns River Water Management District, Florida

    USGS Publications Warehouse

    Walsh, Stephen J.; Knowles, Leel; Katz, Brian G.; Strom, Douglas G.

    2009-01-01

    Hydrologic, physicochemical, and aquatic community data were collected and compiled by the U.S. Geological Survey for selected springs within the St. Johns River Water Management District from January 2004 to October 2007. Nine springs were included in this study: Alexander, Apopka, Bugg, De Leon, Gemini, Green, Rock, Silver Glen, and Wekiwa. Urban lands increased in Alexander, Apopka, De Leon, Gemini, Green, and Wekiwa springsheds between 1973 and 2004, accompanied by a loss of forested and/or agricultural lands in most springsheds. Forested cover increased and open surface waters and wetlands decreased in the Bugg and Rock springsheds. Although rainfall did not change significantly over time in each springshed, spring discharge decreased significantly in De Leon, Fern Hammock, Rock, Silver, and Wekiwa Springs. Nitrate concentrations increased significantly with time in Apopka, Fern Hammock, Gemini Springs run, and Juniper Springs, and decreased significantly in Alexander Spring, Bugg Spring run, Rock Springs, and Wekiwa Springs. Phosphorus increased significantly with time in Juniper Springs and decreased significantly in Apopka, De Leon, Rock, Silver Glen, and Wekiwa Springs. Benthic macroinvertebrate communities ranged from relatively low diversity assemblages (Green Spring) to assemblages with high taxonomic richness, diversity, and dominance (Rock and De Leon Springs). Shannon-Wiener diversity index averages among samples pooled by spring were lowest for Apopka Spring and greatest for Rock, Bugg, and Silver Glen Springs. Mean Stream Condition Index for pooled samples per spring was lowest for De Leon and Gemini Springs and highest for Rock and Wekiwa Springs. Mean percentages of very tolerant taxa were lowest for Alexander Spring and highest for Bugg and Green Springs. Fish community richness was lowest for Green Spring, and greatest for Alexander Spring run and Silver Glen Springs. Forty five fish species representing 35 genera and 23 families were collected or observed from all springs in this study. Samples were dominated by centrarchids, cyprinids, fundulids, atherinopsids, and poeciliids.

  16. Defense.gov - Special Report: Travels with Panetta

    Science.gov Websites

    Flag of Japan Japan Flag of China China Flag of New Zealand New Zealand Top Stories Secretary Honors Past, Present New Zealand Troops Defense Secretary Leon E. Panetta placed a wreath in memory of New Memorial Museum. Story Panetta Eases Restrictions on New Zealand Ship Visits Defense Secretary Leon E

  17. Binational Teacher Development: Teacher Ambassador Exchange Program, New Mexico, USA and Nuevo Leon, Mexico.

    ERIC Educational Resources Information Center

    Habermann, Mary Jean

    The report describes the rationale for and history of an exchange program for Nuevo Leon (Mexico) and New Mexico bilingual education teachers. The program evolved from the need to help Spanish-speaking students maintain their own language and culture while in the United States. New Mexico's state policy concerning language-minority children and…

  18. Situation Report--Australia, Burundi, Cambodia, Mexico, Montserrat, Nicaragua, Papua & New Guinea, Republic of Vietnam, Sabah, Sarawak, Sierra Leone, Tahiti, Tonga.

    ERIC Educational Resources Information Center

    International Planned Parenthood Federation, London (England).

    Data relating to population and family planning in fourteen foreign countries are presented in these situation reports. Countries included are Australia, Burundi, Cambodia, Mexico, Montserrat, Nicaragua, Papua and New Guines, Republic of Vietnam, Sabah, Sarawak, Sierra Leone, Tahiti (French Polynesia), and Tonga. Information is provided under two…

  19. Situation Report--Algeria, Bangladesh, Fiji, Gilbert and Ellice Islands, Iran, Jordan, New Zealand, Rwanda, and Sierra Leone.

    ERIC Educational Resources Information Center

    International Planned Parenthood Federation, London (England).

    Data relating to population and family planning in nine foreign countries are presented in these situation reports. Countries included are Algeria, Bangledesh, Fiji, Gilbert and Ellice Islands, Iran, Jordan, New Zealand, Rwanda, and Sierra Leone. Information is provided under two topics, general background and family planning situation, where…

  20. Socio-Ecological Factors Affecting Pregnant Women's Anemia Status in Freetown, Sierra Leone

    ERIC Educational Resources Information Center

    M'Cormack, Fredanna; Drolet, Judy

    2012-01-01

    Background: Sierra Leone has high maternal mortality. Socio-ecological factors are considered contributing factors to this high mortality. Anemia is considered to be a direct cause of 4% of maternal deaths and an indirect cause of 20-40% of maternal deaths. Purpose: The current study explores socio-ecological contributing factors to the anemia…

  1. The Violence of Peace and the Role of Education: Insights from Sierra Leone

    ERIC Educational Resources Information Center

    Novelli, Mario; Higgins, Sean

    2017-01-01

    Research on peacebuilding has mushroomed over the last decade and there is a growing interest in the role of education in supporting peacebuilding processes. This paper engages with these debates, UN peacebuilding activities and the location of education initiatives therein, through a case study of Sierra Leone. In the first part, we explore the…

  2. Reconstruction versus Transformation: Post-War Education and the Struggle for Gender Equity in Sierra Leone

    ERIC Educational Resources Information Center

    Maclure, Richard; Denov, Myriam

    2009-01-01

    In post-war contexts, education is widely regarded as essential not only for civic reconciliation, but also as a key force for gender equity. In Sierra Leone, however, despite enhanced educational opportunities for girls, much of the emphasis on post-war educational reconstruction is unlikely to rectify gender inequities that remain entrenched…

  3. School Persistence in the Wake of War: Wartime Experiences, Reintegration Supports, and Dropout in Sierra Leone

    ERIC Educational Resources Information Center

    Zuilkowski, Stephanie Simmons; Betancourt, Theresa S.

    2014-01-01

    This article examines the relationship of wartime experience and reintegration supports to students' risk of school dropout. It draws on longitudinal, mixed-methods data collected among children and youth in Sierra Leone from 2002 through 2008. The study finds that family financial support and perceived social support are positively associated…

  4. The Hispanic Heritage of North America: Commemorating 500 Years

    ERIC Educational Resources Information Center

    Cruz, Barbara C.

    2013-01-01

    In April 2013, Florida will commemorate Juan Ponce de Leon's historic voyage. Yet Ponce de Leon's arrival was, in several important ways, not just the beginning of Spain's presence in Florida, but in North America as a whole. Today, the historical Spanish influence on America is palpable--in culture, language, politics, and more. This year marks…

  5. Prevalence of Autism Spectrum Disorders in Guanajuato, Mexico: The Leon Survey

    ERIC Educational Resources Information Center

    Fombonne, Eric; Marcin, Carlos; Manero, Ana Cecilia; Bruno, Ruth; Diaz, Christian; Villalobos, Michele; Ramsay, Katrina; Nealy, Benjamin

    2016-01-01

    There are no epidemiological data on autism for Mexico. This study was conducted to generate a first estimate of ASD prevalence in Mexico. We surveyed children age eight in Leon (Guanajuato). The sample was stratified in two strata: (1) children having special education and medical records (SEMR; N = 432) and (2) children attending regular schools…

  6. Leon Foucault: His Life, Times and Achievements

    ERIC Educational Resources Information Center

    Aczel, Amir D.

    2004-01-01

    Leon Foucault's dramatic demonstration of the rotation of the Earth using a freely-rotating pendulum in 1850 shocked the world of science. Scientists were stunned that such a simple proof of our planet's rotation had to wait so long to be developed. Foucault's public demonstration, which was repeated at many locations around the world, put an end…

  7. Comprehensive Yet Scalable Health Information Systems for Low Resource Settings: A Collaborative Effort in Sierra Leone

    PubMed Central

    Braa, Jørn; Kanter, Andrew S.; Lesh, Neal; Crichton, Ryan; Jolliffe, Bob; Sæbø, Johan; Kossi, Edem; Seebregts, Christopher J.

    2010-01-01

    We address the problem of how to integrate health information systems in low-income African countries in which technical infrastructure and human resources vary wildly within countries. We describe a set of tools to meet the needs of different service areas including managing aggregate indicators, patient level record systems, and mobile tools for community outreach. We present the case of Sierra Leone and use this case to motivate and illustrate an architecture that allows us to provide services at each level of the health system (national, regional, facility and community) and provide different configurations of the tools as appropriate for the individual area. Finally, we present a, collaborative implementation of this approach in Sierra Leone. PMID:21347003

  8. The oldest old and the 90+ Study

    PubMed Central

    Kawas, Claudia H.

    2012-01-01

    Memories are the gifts from friends and family that stay with us forever, unless a person develops Alzheimer's disease. Leon J. Thal left many, many memories, along with his desire to create a world where people did not lose them to the ravages of dementing illnesses. Working from the bench to the clinic, he was an incomparable leader, scientist, and educator to whom many, including myself, owe much. The present description of a clinical, genetic, and pathologic study of the oldest old contains much of Leon's influence. With data from >950 subjects, a brain repository, and our collection of DNA, the investigators of the 90+ Study are receptive to collaborations. Through our collective efforts, we will continue the scientific work that Leon so strongly supported. PMID:18632002

  9. The oldest old and the 90+ Study.

    PubMed

    Kawas, Claudia H

    2008-01-01

    Memories are the gifts from friends and family that stay with us forever, unless a person develops Alzheimer's disease. Leon J. Thal left many, many memories, along with his desire to create a world where people did not lose them to the ravages of dementing illnesses. Working from the bench to the clinic, he was an incomparable leader, scientist, and educator to whom many, including myself, owe much. The present description of a clinical, genetic, and pathologic study of the oldest old contains much of Leon's influence. With data from >950 subjects, a brain repository, and our collection of DNA, the investigators of the 90+ Study are receptive to collaborations. Through our collective efforts, we will continue the scientific work that Leon so strongly supported.

  10. The Topp-Leone generalized Rayleigh cure rate model and its application

    NASA Astrophysics Data System (ADS)

    Nanthaprut, Pimwarat; Bodhisuwan, Winai; Patummasut, Mena

    2017-11-01

    Cure rate model is one of the survival analysis when model consider a proportion of the censored data. In clinical trials, the data represent time to recurrence of event or death of patients are used to improve the efficiency of treatments. Each dataset can be separated into two groups: censored and uncensored data. In this work, the new mixture cure rate model is introduced based on the Topp-Leone generalized Rayleigh distribution. The Bayesian approach is employed to estimate its parameters. In addition, a breast cancer dataset is analyzed for model illustration purpose. According to the deviance information criterion, the Topp-Leone generalized Rayleigh cure rate model shows better result than the Weibull and exponential cure rate models.

  11. Identity with Jesus Christ: the case of Leon Gabor.

    PubMed

    Capps, Donald

    2010-12-01

    From July 1, 1959 to August 15, 1961, Milton Rokeach studied three male patients at Ypsilanti State Hospital who believed that they were Jesus Christ. They met regularly together with Rokeach and his research staff, a procedure designed to challenge their delusional systems. He believed that Leon Gabor, the youngest of the three, would be the most likely to abandon his delusional beliefs. Instead, Leon met the challenges that the procedure posed by creative elaborations of his delusional system, especially through the adoption of a new name that gave the initial appearance of the abandonment of his Christ identity but in fact drew on aspects of the real Jesus Christ's identity that were missing from his earlier self-representation.

  12. Transmission dynamics of Ebola virus disease and intervention effectiveness in Sierra Leone

    PubMed Central

    Fang, Li-Qun; Yang, Yang; Jiang, Jia-Fu; Yao, Hong-Wu; Kargbo, David; Li, Xin-Lou; Jiang, Bao-Gui; Kargbo, Brima; Tong, Yi-Gang; Wang, Ya-Wei; Liu, Kun; Kamara, Abdul; Dafae, Foday; Kanu, Alex; Jiang, Rui-Ruo; Sun, Ye; Sun, Ruo-Xi; Chen, Wan-Jun; Ma, Mai-Juan; Dean, Natalie E.; Thomas, Harold; Longini, Ira M.; Halloran, M. Elizabeth; Cao, Wu-Chun

    2016-01-01

    Sierra Leone is the most severely affected country by an unprecedented outbreak of Ebola virus disease (EVD) in West Africa. Although successfully contained, the transmission dynamics of EVD and the impact of interventions in the country remain unclear. We established a database of confirmed and suspected EVD cases from May 2014 to September 2015 in Sierra Leone and mapped the spatiotemporal distribution of cases at the chiefdom level. A Poisson transmission model revealed that the transmissibility at the chiefdom level, estimated as the average number of secondary infections caused by a patient per week, was reduced by 43% [95% confidence interval (CI): 30%, 52%] after October 2014, when the strategic plan of the United Nations Mission for Emergency Ebola Response was initiated, and by 65% (95% CI: 57%, 71%) after the end of December 2014, when 100% case isolation and safe burials were essentially achieved, both compared with before October 2014. Population density, proximity to Ebola treatment centers, cropland coverage, and atmospheric temperature were associated with EVD transmission. The household secondary attack rate (SAR) was estimated to be 0.059 (95% CI: 0.050, 0.070) for the overall outbreak. The household SAR was reduced by 82%, from 0.093 to 0.017, after the nationwide campaign to achieve 100% case isolation and safe burials had been conducted. This study provides a complete overview of the transmission dynamics of the 2014−2015 EVD outbreak in Sierra Leone at both chiefdom and household levels. The interventions implemented in Sierra Leone seem effective in containing the epidemic, particularly in interrupting household transmission. PMID:27035948

  13. Rapid assessment of knowledge, attitudes, practices, and risk perception related to the prevention and control of Ebola virus disease in three communities of Sierra Leone.

    PubMed

    Jiang, Hai; Shi, Guo-Qing; Tu, Wen-Xiao; Zheng, Can-Jun; Lai, Xue-Hui; Li, Xin-Xu; Wei, Qiang; Li, Mei; Deng, Li-Quan; Huo, Xiang; Chen, Ming-Quan; Xu, Feng; Ye, Long-Jie; Bai, Xi-Chen; Chen, Tong-Nian; Yin, Shao-Hua; Samba, Thomas T; Liang, Xiao-Feng

    2016-06-06

    The recent outbreak of the Ebola virus disease (EVD) in Sierra Leone has been characterized by the World Health Organization as one of the most challenging EVD outbreaks to date. The first confirmed case in Sierra Leone was a young woman who was admitted to a government hospital in Kenema following a miscarriage on 24 May 2014. On 5 January 2015, intensified training for an EVD response project was initiated at the medical university of Sierra Leone in Jui. To understand the knowledge, attitudes, practices, and perceived risk of EVD among the public, especially after this training, a rapid assessment was conducted from 10 to 16 March 2015. Interviews were conducted with 466 participants based on questionnaires that were distributed from 10 to 16 March 2015 by cluster sampling in three adjacent communities, namely Jui, Grafton, and Kossoh Town, in the Western Area Rural District of Sierra Leone. It was found that knowledge about EVD was comprehensive and high. Positive attitude towards prevention was found to be satisfactory. Nearly all participants knew the reporting phone number 117 and had reported some change in behavior since learning about Ebola. More than half (62 %) of the participants had a history of travelling to urban areas, which increases the risk of infection. The multivariable logistic regression analysis showed that community and occupation were variables associated with perceived risk of EVD. Our study showed that community level social mobilization and community engagement were an effective strategy in the special context.

  14. Quantifying surgical capacity in Sierra Leone: a guide for improving surgical care.

    PubMed

    Kingham, T Peter; Kamara, Thaim B; Cherian, Meena N; Gosselin, Richard A; Simkins, Meghan; Meissner, Chris; Foray-Rahall, Lynda; Daoh, Kisito S; Kabia, Soccoh A; Kushner, Adam L

    2009-02-01

    Lack of access to surgical care is a public health crisis in developing countries. There are few data that describe a nation's ability to provide surgical care. This study combines information quantifying the infrastructure, human resources, interventions (ie, procedures), emergency equipment and supplies for resuscitation, and surgical procedures offered at many government hospitals in Sierra Leone. Site visits were performed in 2008 at 10 of the 17 government civilian hospitals in Sierra Leone. The World Health Organization's Tool for Situational Analysis to Assess Emergency and Essential Surgical Care was used to assess surgical capacity. There was a paucity of electricity, running water, oxygen, and fuel at the government hospitals in Sierra Leone. There were only 10 Sierra Leonean surgeons practicing in the surveyed government hospitals. Many procedures performed at most of the hospitals were cesarean sections, hernia repairs, and appendectomies. There were few supplies at any of the hospitals, forcing patients to provide their own. There was a disparity between conditions at the government hospitals and those at the private and mission hospitals. There are severe shortages in all aspects of infrastructure, personnel, and supplies required for delivering surgical care in Sierra Leone. While it will be difficult to improve the infrastructure of government hospitals, training additional personnel to deliver safe surgical care is possible. The situational analysis tool is a valuable mechanism to quantify a nation's surgical capacity. It provides the background data that have been lacking in the discussion of surgery as a public health problem and will assist in gauging the effectiveness of interventions to improve surgical infrastructure and care.

  15. Standing at Sinai with Autism: A Young Man's Bar Mitzvah Journey

    ERIC Educational Resources Information Center

    Hyman, Mia

    2009-01-01

    This article describes the journey that a family and community took to prepare Leon, a young man with autism, for his Bar Mitzvah. A positive behavior support (PBS) intervention was used to prepare Leon for this symbolic rite of passage into the Jewish culture. He had specific problem behaviors that needed to be addressed for him to participate in…

  16. A Comprehensive Vocational Education Program for Career Development in Leon County. Final Report. Volume 1. Program Performance Report.

    ERIC Educational Resources Information Center

    Leon County Schools, Tallahassee, FL.

    The document presents an account of project activities that evolved around the development and implementation of career education in Leon County School District, Florida. The purpose of the project was to begin effecting needed educational changes at the K-14 level by developing a comprehensive career education program designed to increase student…

  17. Examining Internet Usage Demographic Differences and the Relationship between Internet Usage and Business Outcomes in Sierra Leone

    ERIC Educational Resources Information Center

    Kamara, Mohamed K.

    2013-01-01

    This study utilized the unified theory of acceptance and use of technology (UTAUT) to determine Internet users' perceptions and behavioral intentions to accept Wi-Fi technology deployment in Sierra Leone. The study sought to investigate (a) the Internet usage rates before and after Wi-Fi adaption in Freetown; (b) differences in Internet usage…

  18. Learning Styles and Attitudes toward Online Education in Four Universities in the State of Nuevo Leon, Mexico

    ERIC Educational Resources Information Center

    Martinez de Monarrez, Patricia; Korniejczuk, Victor

    2013-01-01

    The purpose of this research was to find the relation-ship between the predominant learning styles among university online students and their attitude toward online education. Data were collected from 385 students enrolled in undergraduate and graduate programs from four universities in the state of Nuevo Leon, Mexico. Significant effects of…

  19. Empowering Women through Education: Evidence from Sierra Leone. NBER Working Paper No. 18016

    ERIC Educational Resources Information Center

    Mocan, Naci H.; Cannonier, Colin

    2012-01-01

    We use data from Sierra Leone where a substantial education program provided increased access to education for primary-school age children but did not benefit children who were older. We exploit the variation in access to the program generated by date of birth and the variation in resources between various districts of the country. We find that…

  20. Rural-Urban Migration in Sierra Leone: Determinants and Policy Implications. African Rural Economy Paper No. 13.

    ERIC Educational Resources Information Center

    Byerlee, Derek; And Others

    Study objectives were to: increase the understanding of rural to urban migration processes in Africa and Sierra Leone; develop and test a theoretical schema and survey methodology for migration research; and evaluate the effects of policy on migration. The migration survey was conducted in rural areas, urban areas, and again in the rural areas…

  1. War and deforestation in Sierra Leone

    NASA Astrophysics Data System (ADS)

    Burgess, Robin; Miguel, Edward; Stanton, Charlotte

    2015-09-01

    The impact of armed conflict on the environment is of major public policy importance. We use a geographically disaggregated dataset of civil war violence together with satellite imagery of land cover to test whether war facilitated or prevented forest loss in Sierra Leone. The conflict data set allows us to establish where rebel groups were stationed and where battles and attacks occurred. The satellite data enables to us to monitor the change in forest cover (total, primary, and secondary) in all of Sierra Leone’s 151 chiefdoms, between 1990 (prior to the war) and 2000 (just prior to its end). The results suggest that conflict in Sierra Leone acted as a brake on local deforestation: conflict-ridden areas experienced significantly less forest loss relative to their more conflict-free counterparts.

  2. An Introduction to Isaac Leon Kandel: Who He Was and Why He Matters

    ERIC Educational Resources Information Center

    Null, J. Wesley

    2007-01-01

    Few professors of education in the 21st century know the name Isaac Leon Kandel. A Kappa Delta Pi Laureate and author of more than 20 books, Kandel may be known to scholars who specialize in comparative education or educational history; however, Kandel is known to very few beyond these two fields. This article is a testament to Kandel, his…

  3. Risk Assessments for the Insect Repellents DEET and Picaridin

    DTIC Science & Technology

    2008-01-01

    aDepartment of Land Resources and Environmental Sciences, Montana State University, 334 Leon Johnson Hall, Bozeman, MT 59717-3120, USA b Sacramento...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Montana State University,Department of Land Resources and Environmental Sciences,334 Leon Johnson...2007), Macedo et al. (2007), and Schleier et al. (2008) have estimated hu- man health and environmental risks from other mosquito manage- ment and

  4. "Farming Miners" or "Mining Farmers"?: Diamond Mining and Rural Development in Post-Conflict Sierra Leone

    ERIC Educational Resources Information Center

    Maconachie, Roy; Binns, Tony

    2007-01-01

    Sierra Leone is currently emerging from a brutal civil war that lasted most of the 1990s, and now has the dubious distinction of being ranked among the world's poorest countries. As thousands of displaced people move back to their villages, a large proportion of the predominantly farm-based rural population are growing food crops for the first…

  5. Sierra Leone's Former Child Soldiers: A Follow-Up Study of Psychosocial Adjustment and Community Reintegration

    ERIC Educational Resources Information Center

    Betancourt, Theresa Stichick; Borisova, Ivelina Ivanova; Williams, Timothy Philip; Brennan, Robert T.; Whitfield, Theodore H.; de la Soudiere, Marie; Williamson, John; Gilman, Stephen E.

    2010-01-01

    This is the first prospective study to investigate psychosocial adjustment in male and female former child soldiers (ages 10-18; n = 156, 12% female). The study began in Sierra Leone in 2002 and was designed to examine both risk and protective factors in psychosocial adjustment. Over the 2-year period of follow-up, youth who had wounded or killed…

  6. Implementing an Ebola Vaccine Study - Sierra Leone.

    PubMed

    Widdowson, Marc-Alain; Schrag, Stephanie J; Carter, Rosalind J; Carr, Wendy; Legardy-Williams, Jennifer; Gibson, Laura; Lisk, Durodami R; Jalloh, Mohamed I; Bash-Taqi, Donald A; Kargbo, Samuel A Sheku; Idriss, Ayesha; Deen, Gibrilla F; Russell, James B W; McDonald, Wendi; Albert, Alison P; Basket, Michelle; Callis, Amy; Carter, Victoria M; Ogunsanya, Kelli R Clifton; Gee, Julianne; Pinner, Robert; Mahon, Barbara E; Goldstein, Susan T; Seward, Jane F; Samai, Mohamed; Schuchat, Anne

    2016-07-08

    In October 2014, the College of Medicine and Allied Health Sciences of the University of Sierra Leone, the Sierra Leone Ministry of Health and Sanitation, and CDC joined the global effort to accelerate assessment and availability of candidate Ebola vaccines and began planning for the Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE). STRIVE was an individually randomized controlled phase II/III trial to evaluate efficacy, immunogenicity, and safety of the recombinant vesicular stomatitis virus Ebola vaccine (rVSV-ZEBOV). The study population was health care and frontline workers in select chiefdoms of the five most affected districts in Sierra Leone. Participants were randomized to receive a single intramuscular dose of rVSV-ZEBOV at enrollment or to receive a single intramuscular dose 18-24 weeks after enrollment. All participants were followed up monthly until 6 months after vaccination. Two substudies separately assessed detailed reactogenicity over 1 month and immunogenicity over 12 months. During the 5 months before the trial, STRIVE and partners built a research platform in Sierra Leone comprising participant follow-up sites, cold chain, reliable power supply, and vaccination clinics and hired and trained at least 350 national staff. Wide-ranging community outreach, informational sessions, and messaging were conducted before and during the trial to ensure full communication to the population of the study area regarding procedures and current knowledge about the trial vaccine. During April 9-August 15, 2015, STRIVE enrolled 8,673 participants, of whom 453 and 539 were also enrolled in the safety and immunogenicity substudies, respectively. As of April 28, 2016, no Ebola cases and no vaccine-related serious adverse events, which by regulatory definition include death, life-threatening illness, hospitalization or prolongation of hospitalization, or permanent disability, were reported in the study population. Although STRIVE will not produce an estimate of vaccine efficacy because of low case frequency as the epidemic was controlled, data on safety and immunogenicity will support decisions on licensure of rVSV-ZEBOV.The activities summarized in this report would not have been possible without collaboration with many U.S. and international partners (http://www.cdc.gov/vhf/ebola/outbreaks/2014-west-africa/partners.html).

  7. Distance, accessibility and costs. Decision-making during childbirth in rural Sierra Leone: A qualitative study.

    PubMed

    Treacy, Laura; Bolkan, Håkon A; Sagbakken, Mette

    2018-01-01

    Sierra Leone has one of the highest maternal mortality ratios in the world. Efforts to reduce maternal mortality have included initiatives to encourage more women to deliver at health facilities. Despite the introduction of the free health care initiative for pregnant women, many women still continue to deliver at home, with few having access to a skilled birth attendant. In addition, inequalities between rural and urban areas in accessing and utilising health facilities persist. Further insight into how and why women make decisions around childbirth will help guide future plans and initiatives in improving maternal health in Sierra Leone. The objective of this study was to explore the perceptions and decision-making processes of women and their communities during childbirth in rural Sierra Leone. Data were collected through seven focus group discussions and 22 in-depth interviews with recently pregnant women and their community members in two rural villages. Data were analysed using systematic text condensation. Findings revealed that decision-making processes during childbirth are dynamic, intricate and need to be understood within the broader social context that they take place. Factors such as distance and lack of transport, perceived negative behaviour of hospital staff, direct and indirect financial obstacles, as well as the position of women in society all interact and influence how and what decisions are made. Pregnant women face multiple interacting vulnerabilities that influence their healthcare-seeking decisions during pregnancy and childbirth. Future initiatives to improve access and utilisation of safe healthcare services for pregnant women need to be based on adequate knowledge of structural constraints and health inequities that affect women in rural Sierra Leone.

  8. Nationally representative household survey of surgery and mortality in Sierra Leone.

    PubMed

    Kwon, Steve; Groen, Reinou S; Kamara, Thaim B; Cassidy, Laura D; Samai, Mohamed; Yambasu, Sahr E; Kushner, Adam L

    2013-08-01

    There is limited evidence to characterize the burden of unmet need of surgical diseases in low- and middle-income countries. The purpose of this study was to determine rate of deaths attributable to a surgical condition and reasons for not seeking surgical care in Sierra Leone. The Surgeons OverSeas Assessment of Surgical Need (SOSAS) is a survey tool developed collaboratively to be used for cross-sectional data collection of the prevalence of surgical conditions in any country. A population-weighted cluster-sample household survey was conducted throughout Sierra Leone in 2012 using the SOSAS survey tool. Total of 1,840 households (11,870 individuals) were sampled, yielding a 98.3 % response rate. Overall, there were 709 total deaths reported (6.0 %). The mean age at death was 36.4 ± 30.1 years: 330 (46.6 %) were female. Most deaths occurred at home (58.1 % vs. 34.1 % in hospitals). Of the 709 deaths, 237 (33.4 %) were associated with conditions included in our predefined surgical disease category. Abdominal distension/pain was the most commonly associated surgical condition (13.9 %) followed by perinatal bleeding/illness (6.0 %). Among the 237 with surgical conditions, 51 (21.9 %) did not seek medical care, most commonly because of a lack of money (35.3 %) or inability to provide timely care (37.3 %). A large proportion of deaths in Sierra Leone was associated with surgical conditions, the majority of which did not undergo surgical intervention. Our results indicate that to remove barriers to effective surgical care in Sierra Leone policymakers should first focus on relieving financial burdens and increasing access to timely surgical care.

  9. Improving access to surgery in a developing country: experience from a surgical collaboration in Sierra Leone.

    PubMed

    Kushner, Adam L; Kamara, Thaim B; Groen, Reinou S; Fadlu-Deen, Betsy D; Doah, Kisito S; Kingham, T Peter

    2010-01-01

    Although surgery is increasingly recognized as an essential component of primary health care, there has been little documentation of surgical programs in low- and middle-income countries. Surgeons OverSeas (SOS) is a New York-based organization with a mission to save lives in developing countries by improving surgical care. This article highlights the surgical program in Sierra Leone as a possible model to improve access to surgery. An SOS team conducted a needs assessment of surgical capacity in Sierra Leone in February 2008. Interventions were then developed and programs were implemented. A follow-up assessment was conducted in December 2009, which included interviews of key Sierra Leone hospital personnel and a review of operating room log books. Based on an initial needs assessment, a program was developed that included training, salary support, and the provision of surgical supplies and equipment. Two 3-day workshops were conducted for a total of 44 health workers, salary support given to over 100 staff, and 2 containers of supplies and equipment were donated. Access to surgery, as measured by the number of major operations at Connaught Hospital, increased from 460 cases in 2007 to 768 cases in 2009. The SOS program in Sierra Leone highlights a method for improving access to surgery that incorporates an initial needs assessment with minimal external support and local staff collaboration. The program functions as a catalyst by providing training, salary support, and supplies. The beneficial results of the program can then be used to advocate for additional resources for surgery from policy makers. This model could be beneficial in other resource-poor countries in which improved access to surgery is desired. Copyright 2010 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

  10. Lie symmetry analysis, Bäcklund transformations, and exact solutions of a (2 + 1)-dimensional Boiti-Leon-Pempinelli system

    NASA Astrophysics Data System (ADS)

    Zhao, Zhonglong; Han, Bo

    2017-10-01

    In this paper, the Lie symmetry analysis method is employed to investigate the Lie point symmetries and the one-parameter transformation groups of a (2 + 1)-dimensional Boiti-Leon-Pempinelli system. By using Ibragimov's method, the optimal system of one-dimensional subalgebras of this system is constructed. Truncated Painlevé analysis is used for deriving the Bäcklund transformation. The method of constructing lump-type solutions of integrable equations by means of Bäcklund transformation is first presented. Meanwhile, the lump-type solutions of the (2 + 1)-dimensional Boiti-Leon-Pempinelli system are obtained. The lump-type wave is one kind of rogue wave. The fusion-type N-solitary wave solutions are also constructed. In addition, this system is integrable in terms of the consistent Riccati expansion method.

  11. [Adverse reactions to mosquito bites in scholars from Monterrey, Nuevo Leon, Mexico].

    PubMed

    Manrique López, María Amelia; González Díaz, Sandra N; Arias Cruz, Alfredo; Sedó Mejía, Giovanni A; Canseco Villarreal, José Ignacio; Gómez Retamoza, Ernesto Antonio; Padrón López, Olga Magdalena; Cruz Moreno, Miguel Angel; Cisneros Salazar, Guillermo Daniel

    2010-01-01

    Allergic reactions to insect bites are a global problem, the true incidence and prevalence of morbidity from adverse reactions to mosquito bites are unknown. To describe the adverse reactions to mosquito bites in school-age children of Monterrey, Nuevo Leon. A cross-sectional descriptive study was made via a randomized application of questionnaires to children from public elementary schools in the metropolitan area of Monterrey, Nuevo Leon. A total of 11 public schools randomly selected were included in the study. One thousand questionnaires were submitted, of which 506 fulfilled the inclusion criteria; 55% were females. Seventy-six percent referred adverse reactions to mosquito bites, itching (75%) and rash (72%) being the most frequent ones, in the last 12 months. Adverse reactions to mosquito bites occur frequently. Early detection is important to establish a prompt treatment.

  12. Exceptional suffering? Enumeration and vernacular accounting in the HIV-positive experience.

    PubMed

    Benton, Adia

    2012-01-01

    Drawing on 17 months of ethnographic fieldwork in Freetown, Sierra Leone, I highlight the recursive relationship between Sierra Leone as an exemplary setting and HIV as an exceptional disease. Through this relationship, I examine how HIV-positive individuals rely on both enumerative knowledge (seroprevalence rates) and vernacular accounting (NGO narratives of vulnerability) to communicate the uniqueness of their experience as HIV sufferers and to demarcate the boundaries of their status. Various observers' enumerative and vernacular accounts of Sierra Leone's decade-long civil conflict, coupled with global health accounts of HIV as exceptional, reveal the calculus of power through which global health projects operate. The contradictions between the exemplary and the exceptional-and the accompanying tension between quantitative and qualitative facts-are mutually constituted in performances and claims made by HIV-positive individuals themselves.

  13. Undiagnosed Acute Viral Febrile Illnesses, Sierra Leone

    DTIC Science & Technology

    2014-07-01

    Sierra Leone in West Africa is in a Lassa fever – hyperendemic region that also includes Guinea and Li- beria. Each year...suspected Lassa fever cases result in submission of ≈500–700 samples to the Kenema Govern- ment Hospital Lassa Diagnostic Laboratory in eastern Si- erra...patients have acute diseases of unknown origin. To investigate what other ar- thropod-borne and hemorrhagic fever viral diseases might cause serious

  14. An Examination of Primary School Attendance and Completion among Secondary School Age Adolescents in Post-Conflict Sierra Leone

    ERIC Educational Resources Information Center

    Moyi, Peter

    2013-01-01

    Sierra Leone was ravaged by a civil war between 1991 and 2002. Since the end of the war, it has witnessed an unprecedented increase in school enrollments. Although school enrollment has increased, the number of school age children who are out of school remains high. The focus of international agencies is on children of primary school age, yet a…

  15. Does Community Poverty Reduce Children's School Attendance More at Primary Education than at Secondary Education? Evidence from Post-Conflict Sierra Leone

    ERIC Educational Resources Information Center

    Kamanda, Mamusu

    2016-01-01

    In Sierra Leone, the number of primary schools is almost seven times more than junior-secondary schools (JSS). Living in a poor community has been shown to reduce children's school attendance because of lower access and poorer quality of education in these communities. However, it is unclear whether living in a poor community reduces attendance at…

  16. The Role of Non-Governmental Organisations and Faith-Based Organisations in Achieving Education for All: The Case of Sierra Leone

    ERIC Educational Resources Information Center

    Nishimuko, Mikako

    2009-01-01

    Sierra Leone, one of the world's poorest countries, experienced a civil war from 1991 to 2002. The government's capacity to provide educational services remains weak, and still over 30% of children in the country are hard to reach and do not have access to primary education. This paper discusses the role of non-governmental organisations (NGOs)…

  17. Notes from the Field: Ebola Virus Disease Response Activities During a Mass Displacement Event After Flooding--Freetown, Sierra Leone, September-November, 2015.

    PubMed

    Ratto, Jeffrey; Ivy, Wade; Purfield, Anne; Bangura, James; Omoko, Anthony; Boateng, Isaac; Duffy, Nadia; Sims, George; Beamer, Bryan; Pi-Sunyer, Teresa; Kamara, Sarian; Conteh, Sulaiman; Redd, John

    2016-02-26

    Since the start of the Ebola virus disease (Ebola) outbreak in West Africa, Sierra Leone has reported 8,706 confirmed Ebola cases and 3,956 deaths. During September 15-16, 2015, heavy rains flooded the capital, Freetown, resulting in eight deaths, home and property destruction, and thousands of persons in need of assistance. By September 27, approximately 13,000 flood-affected persons registered for flood relief services from the government. On September 17, two stadiums in Freetown were opened to provide shelter and assistance to flood-affected residents; a total of approximately 3,000 persons stayed overnight in both stadiums (Sierra Leone Ministry of Health and Sanitation, personal communication, September 2015). On the same day the stadiums were opened to flood-affected persons, the Ministry of Health and Sanitation (MoHS) and Western Area Ebola Response Center (WAERC) staff members from CDC, the World Health Organization (WHO), and the African Union evaluated the layout, logistics, and services at both stadiums and identified an immediate need to establish Ebola response activities. The patient in the last Ebola case in the Western Area, which includes Freetown, had died 37 days earlier, on August 11; however, transmission elsewhere in Sierra Leone was ongoing, and movement of persons throughout the country was common.

  18. [Establishment of Quality Control System of Nucleic Acid Detection for Ebola Virus in Sierra Leone-China Friendship Biological Safety Laboratory].

    PubMed

    Wang, Qin; Zhang, Yong; Nie, Kai; Wang, Huanyu; Du, Haijun; Song, Jingdong; Xiao, Kang; Lei, Wenwen; Guo, Jianqiang; Wei, Hejiang; Cai, Kun; Wang, Yanhai; Wu, Jiang; Gerald, Bangura; Kamara, Idrissa Laybohr; Liang, Mifang; Wu, Guizhen; Dong, Xiaoping

    2016-03-01

    The quality control process throughout the Ebola virus nucleic acid detection in Sierra Leone-China Friendship Biological Safety Laboratory (SLE-CHN Biosafety Lab) was described in detail, in order to comprehensively display the scientific, rigorous, accurate and efficient practice in detection of Ebola virus of first batch detection team in SLE-CHN Biosafety Lab. Firstly, the key points of laboratory quality control system was described, including the managements and organizing, quality control documents and information management, instrument, reagents and supplies, assessment, facilities design and space allocation, laboratory maintenance and biosecurity. Secondly, the application of quality control methods in the whole process of the Ebola virus detection, including before the test, during the test and after the test, was analyzed. The excellent and professional laboratory staffs, the implementation of humanized management are the cornerstone of the success; High-level biological safety protection is the premise for effective quality control and completion of Ebola virus detection tasks. And professional logistics is prerequisite for launching the laboratory diagnosis of Ebola virus. The establishment and running of SLE-CHN Biosafety Lab has landmark significance for the friendship between Sierra Leone and China, and the lab becomes the most important base for Ebola virus laboratory testing in Sierra Leone.

  19. Mission Planning for Heterogeneous UxVs Operating in a Post-Disaster Urban Environment

    DTIC Science & Technology

    2017-09-01

    FOR HETEROGENEOUS UxVs OPERATING IN A POST -DISASTER URBAN ENVIRONMENT by Choon Seng Leon Mark Tan September 2017 Thesis Advisor: Oleg...September 2017 3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE MISSION PLANNING FOR HETEROGENEOUS UxVs OPERATING IN A POST ...UxVs OPERATING IN A POST -DISASTER URBAN ENVIRONMENT Choon Seng Leon Mark Tan Civilian Engineer, ST Aerospace Ltd., Singapore B. Eng (Hons

  20. Rice Production. A Training Manual and Field Guide to Small-Farm Irrigated Rice Production. Appropriate Technologies for Development. Reprint No. R-40.

    ERIC Educational Resources Information Center

    Morris, Michael L., Ed.

    This manual presents a simple, step-by-step description of irrigated rice production in Sierra Leone. It is geared specifically to the role and needs of Peace Corps volunteers who, since the mid-1970s, have worked as agricultural extension agents in the Sierra Leone Ministry of Agriculture and Forestry. The manual is designed to serve both as a…

  1. Sequence Variability and Geographic Distribution of Lassa Virus, Sierra Leone

    PubMed Central

    Stockelman, Michael G.; Moses, Lina M.; Park, Matthew; Stenger, David A.; Ansumana, Rashid; Bausch, Daniel G.; Lin, Baochuan

    2015-01-01

    Lassa virus (LASV) is endemic to parts of West Africa and causes highly fatal hemorrhagic fever. The multimammate rat (Mastomys natalensis) is the only known reservoir of LASV. Most human infections result from zoonotic transmission. The very diverse LASV genome has 4 major lineages associated with different geographic locations. We used reverse transcription PCR and resequencing microarrays to detect LASV in 41 of 214 samples from rodents captured at 8 locations in Sierra Leone. Phylogenetic analysis of partial sequences of nucleoprotein (NP), glycoprotein precursor (GPC), and polymerase (L) genes showed 5 separate clades within lineage IV of LASV in this country. The sequence diversity was higher than previously observed; mean diversity was 7.01% for nucleoprotein gene at the nucleotide level. These results may have major implications for designing diagnostic tests and therapeutic agents for LASV infections in Sierra Leone. PMID:25811712

  2. Bioaccumulation of lead, copper, iron, and zinc by fish in a transect of the Santa Catarina River in Cadereyta Jimenez, Nuevo Leon, Mexico

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1986-09-01

    Changes have been observed in the ichthyic species community, upriver in the San Juan River in Nuevo Leon, Mexico. A disappearance of Notropis amabilis, Notropis stramineus, Dionda episcopa and Campostoma anomalum and an increased mortality of Astyanax mexicanus, Lepomis macrochirus and Cichlasoma cyanoguttatum have been found. These changes were probably due to industrial and domestic discharges which produced high levels of lead, copper, iron and detergents in the water. The investigation reported here was done in order to detect the possible presence of lead, copper, iron and zinc in the river waters and also, to determine a probable bioaccumulation ofmore » these metals in fish species of the Santa Catarina River in the state of Nuevo Leon in northeastern Mexico, since this river transports domestic and industrial wastes of urban and suburban zones.« less

  3. The burden of musculoskeletal disease in Sierra Leone.

    PubMed

    Elliott, Iain S; Groen, Reinou S; Kamara, Thaim B; Ertl, Allison; Cassidy, Laura D; Kushner, Adam L; Gosselin, Richard A

    2015-01-01

    Musculoskeletal disease is a major cause of disability in the global burden of disease, yet data regarding the magnitude of this burden in developing countries are lacking. The Surgeons OverSeas Assessment of Surgical Need (SOSAS) survey was designed to measure the incidence and prevalence of surgically treatable conditions, including musculoskeletal conditions, in patients in low- and middle-income countries, and was administered in the West African nation of Sierra Leone in 2012. We attempted to quantify the burden of potentially treatable musculoskeletal conditions in patients in Sierra Leone. A cross-sectional two-stage cluster-based survey was performed in Sierra Leone using the SOSAS. Two individuals from each randomly selected household underwent a verbal head to toe examination. The musculoskeletal-related questions from the SOSAS survey in Sierra Leone were analyzed to determine the prevalence of musculoskeletal problems in the study population. Prevalence is reported as the number of respondents with a musculoskeletal problem now and number of respondents with a musculoskeletal problem during the past year. Respondents had "no need" for care, they "received care", or they faced a barrier that prevented them from receiving care. One thousand eight hundred seventy-five households were targeted, with 1843 undergoing the survey, which yielded 3645 individual respondents. Of the individual respondents, 462 (n=3645; 12.6% of total; 95% CI, 12%-13%) had a traumatic musculoskeletal problem during the past year, and 236 (n=3645; 6% of total; 95% CI, 5%-7%) respondents had a musculoskeletal problem of nontraumatic etiology. Of respondents with either a traumatic or nontraumatic musculoskeletal problem, 359 (n=562; 63.9% of total; 95% CI, 59.5-68.3%) needed care but were unable to receive it with the major barrier reported as financial. Resource allocation decisions in global health are made based on burden of disease data in low- and middle-income countries. The data provided here for Sierra Leone may offer some generalizable insight into the scope of the burden of musculoskeletal disease for low- and middle-income countries, especially in Sub-Saharan Africa, and provide concrete evidence that musculoskeletal health should be included in the global health discussion. However, there may be important differences across countries in this region, and further study to elucidate these differences seems critical given the large burden of disease and the limited resources available in these regions to manage it.

  4. AN ANTHOLOGY OF KRIO FOLKLORE AND LITERATURE, WITH NOTES AND INTERLINEAR TRANSLATION IN ENGLISH. VOLUME 1 OF THE KRIO LANGUAGE OF SIERRA LEONE, WEST AFRICA, IN TWO VOLUMES.

    ERIC Educational Resources Information Center

    TURNER, LORENZO D.

    MOST OF THE KRIO FOLKLORE AND LITERATURE TRANSCRIBED IN THIS VOLUME HAS NEVER BEFORE APPEARED IN PRINT. IT IS INTENDED FOR THE PEOPLE OF SIERRA LEONE THEMSELVES, AS WELL AS FOR PERSONS WHO WISH TO LEARN MORE ABOUT WEST AFRICAN CULTURE AND THE KRIO LANGUAGE. INCLUDED IN THE FOLKLORE RECORDED HERE ARE PROVERBS, RIDDLES, AND FOLK TALES GATHERED IN…

  5. R2PL 2005 - Proceedings of the First International Workshop on Reengineering towards Product Lines

    DTIC Science & Technology

    2006-03-01

    thinking. Other domain engineer- ing approaches are FODA [6] and FORM [7]. Typically these approaches are based on the analysis of high-level...November 1998. [6] Kyo C. Kang, Sholom G. Cohen, James A. Hess, William E. Novak, and A. Spencer Peterson. Feature-oriented do- main analysis ( FODA ... Analysis � by Bas Graaf, Bas Cornelissen, and Leon Moonen. © 2006 by Bas Graaf, Bas Cornelissen, and Leon Moonen. �Identifying Domain-Specific

  6. Few Mode Multicore Photonic Lantern Multiplexer

    DTIC Science & Technology

    2016-01-01

    2015, Valencia (2015). [6] S. G. Leon-Saval, T. A. Birks, J. Bland- Hawthorn , and M. Englund, “Multimode fiber devices with single-mode performance...Opt. Lett. 30, 2545–2547 (2005). [7] D. Noordegraaf, P. M. W. Skovgaard, M. D. Nielsen, and J. Bland- Hawthorn , “Efficient multi-mode to single mode...coupling in a photonic lantern,” Opt. Express 17, 1988–1994 (2009). [8] S. G. Leon-Saval, A. Argyros, and J. Bland- Hawthorn , “Photonic lanterns: a

  7. Virtual Platform for See Robustness Verification of Bootloader Embedded Software on Board Solar Orbiter's Energetic Particle Detector

    NASA Astrophysics Data System (ADS)

    Da Silva, A.; Sánchez Prieto, S.; Polo, O.; Parra Espada, P.

    2013-05-01

    Because of the tough robustness requirements in space software development, it is imperative to carry out verification tasks at a very early development stage to ensure that the implemented exception mechanisms work properly. All this should be done long time before the real hardware is available. But even if real hardware is available the verification of software fault tolerance mechanisms can be difficult since real faulty situations must be systematically and artificially brought about which can be imposible on real hardware. To solve this problem the Alcala Space Research Group (SRG) has developed a LEON2 virtual platform (Leon2ViP) with fault injection capabilities. This way it is posible to run the exact same target binary software as runs on the physical system in a more controlled and deterministic environment, allowing a more strict requirements verification. Leon2ViP enables unmanned and tightly focused fault injection campaigns, not possible otherwise, in order to expose and diagnose flaws in the software implementation early. Furthermore, the use of a virtual hardware-in-the-loop approach makes it possible to carry out preliminary integration tests with the spacecraft emulator or the sensors. The use of Leon2ViP has meant a signicant improvement, in both time and cost, in the development and verification processes of the Instrument Control Unit boot software on board Solar Orbiter's Energetic Particle Detector.

  8. Too Far to Care? Measuring Public Attention and Fear for Ebola Using Twitter.

    PubMed

    van Lent, Liza Gg; Sungur, Hande; Kunneman, Florian A; van de Velde, Bob; Das, Enny

    2017-06-13

    In 2014, the world was startled by a sudden outbreak of Ebola. Although Ebola infections and deaths occurred almost exclusively in Guinea, Sierra Leone, and Liberia, few potential Western cases, in particular, caused a great stir among the public in Western countries. This study builds on the construal level theory to examine the relationship between psychological distance to an epidemic and public attention and sentiment expressed on Twitter. Whereas previous research has shown the potential of social media to assess real-time public opinion and sentiment, generalizable insights that further the theory development lack. Epidemiological data (number of Ebola infections and fatalities) and media data (tweet volume and key events reported in the media) were collected for the 2014 Ebola outbreak, and Twitter content from the Netherlands was coded for (1) expressions of fear for self or fear for others and (2) psychological distance of the outbreak to the tweet source. Longitudinal relations were compared using vector error correction model (VECM) methodology. Analyses based on 4500 tweets revealed that increases in public attention to Ebola co-occurred with severe world events related to the epidemic, but not all severe events evoked fear. As hypothesized, Web-based public attention and expressions of fear responded mainly to the psychological distance of the epidemic. A chi-square test showed a significant positive relation between proximity and fear: χ 2 2 =103.2 (P<.001). Public attention and fear for self in the Netherlands showed peaks when Ebola became spatially closer by crossing the Mediterranean Sea and Atlantic Ocean. Fear for others was mostly predicted by the social distance to the affected parties. Spatial and social distance are important predictors of public attention to worldwide crisis such as epidemics. These factors need to be taken into account when communicating about human tragedies. ©Liza GG van Lent, Hande Sungur, Florian A Kunneman, Bob van de Velde, Enny Das. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 13.06.2017.

  9. Health complications of female genital mutilation in Sierra Leone

    PubMed Central

    Bjälkander, Owolabi; Bangura, Laurel; Leigh, Bailah; Berggren, Vanja; Bergström, Staffan; Almroth, Lars

    2012-01-01

    Sierra Leone has one of the highest rates of female genital mutilation (FGM) in the world, and yet little is known about the health consequences of the practice. Purpose To explore whether and what kind of FGM-related health complications girls and women in Sierra Leone experience, and to elucidate their health care-seeking behaviors. Patients and methods A feasibility study was conducted to test and refine questionnaires and methods used for this study. Thereafter, a cross-section of girls and women (n = 258) attending antenatal care and Well Women Clinics in Bo Town, Bo District, in the southern region and in Makeni Town, Bombali District, in the northern region of Sierra Leone were randomly selected. Participants answered interview-administrated pretested structured questionnaires with open- ended-questions, administrated by trained female personnel. Results All respondents had undergone FGM, most between 10 and 14 years of age. Complications were reported by 218 respondents (84.5%), the most common ones being excessive bleeding, delay in or incomplete healing, and tenderness. Fever was significantly more often reported by girls who had undergone FGM before 10 years of age compared with those who had undergone the procedure later. Out of those who reported complications, 187 (85.8%) sought treatment, with 89 of them visiting a traditional healer, 75 a Sowei (traditional circumciser), and 16 a health professional. Conclusion The high prevalence rate of FGM and the proportion of medical complications show that FGM is a matter for public health concern in Sierra Leone. Girls who undergo FGM before 10 years of age seem to be more vulnerable to serious complications than those who are older at the time of FGM. It is important that health care personnel are aware of, and look for possible complications from FGM, and encourage girls and women to seek medical care for their problems. PMID:22870046

  10. Assessment on the Knowledge and Reported Practices of Women on Maternal and Child Health in Rural Sierra Leone: A Cross-Sectional Survey

    PubMed Central

    Kanu, Joseph Sam; Tang, Yuan; Liu, Yawen

    2014-01-01

    Background Globally, Sierra Leone is ranked among the countries with the worst maternal and child health indicators. The mortality of women and children is significantly higher compared with other developing countries. The death of women and children can be prevented by simple cost-effective community-based interventions. The aim of this present study was to learn the knowledge levels of women on maternal and child health, and treatment-seeking and preventive behaviours in rural Sierra Leone and provide appropriate suggestions for policy makers. Moreover, the study also aimed to evaluate the effect of a husband’s involvement on health knowledge and practices of women in rural Sierra Leone. Methods Women with at least a child of five years or below were interviewed in their households through a structured questionnaire. Characteristics of the households and of the respondents were collected and the number of correct answers given to the health knowledge and practice questions and their percentage distributions were tabulated and an overall health knowledge score was calculated. Results The mean score of the derived overall health-related knowledge was 61.6% (maximum of 91% and a minimum of 18%) with a standard deviation of 14.7% and a median of 63.3%. Multivariable regression analyses showed education and number of pregnancies are associated with knowledge score, with significantly improved health knowledge scores amongst those who accessed higher education. There were some inappropriate practices in hygiene and sanitation. However, vaccination coverage was high with almost 100% coverage for BCG. Conclusions Based on the findings of this study, women’s knowledge on maternal and child health care are inadequate in rural Sierra Leone. Health promotion activities focusing on prevention of diarrhoea, malaria and pneumonia, improvement in health-related knowledge on pregnancy, delivery, neonatal care and environmental sanitation would be invaluable. PMID:25166504

  11. Prevalence and Risk Factors for Human Immunodeficiency Virus (HIV) and Syphilis Infections Among Military Personnel in Sierra Leone.

    PubMed

    Djibo, Djeneba Audrey; Sahr, Foday; McCutchan, J Allen; Jain, Sonia; Araneta, Maria Rosario G; Brodine, Stephanie K; Shaffer, Richard A

    2017-01-01

    HIV and syphilis infections are common in military personnel in sub-Saharan Africa, which impact combat preparedness and increase demands on the military health care system. The prevalence of HIV is estimated at 1.5% among the general population (15-49 years of age) of Sierra Leone, and the estimated syphilis prevalence ranged from 1.5% to 5.2% based on regional studies. We examined the prevalence and risk factors for these two common sexually transmitted infections in the Sierra Leone military personnel. This cross-sectional study examined 1157 randomly selected soldiers from the Republic of Sierra Leone Armed Forces in 2013 using computer-assisted personal interviews and rapid testing algorithms. Descriptive statistics and logistic regression models were implemented to identify risk factors for HIV and syphilis separately. The mean age of participants was 38 years, 11.1% were female, and 86.5% were married. The seroprevalence of HIV and syphilis were 3.3% (95% confidence interval [CI]: 2.3%-4.3%) and 7.3% (95% CI: 5.9%-8.8%), respectively. Lower educational attainment in women, multiple sexual partners, unintended sex after alcohol use and use of condoms were independently associated with HIV status (p<0.05). After adjustment, HIV infection was associated with female gender, unintended sex after alcohol use, condom use at last sex, having multiple sexual partnerships in the same week and HIV testing outside of military facilities (p<0.05). Increasing age, positive HIV status and rural regions of residence were associated with syphilis seropositivity. The prevalence of sexually transmitted infections among military personnel was higher than the general population of Sierra Leone. Several high-risk sexual behaviors that expose soldiers to HIV and syphilis could be addressed through prevention interventions. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  12. Geoheritage value of the UNESCO site at Leon Viejo and Momotombo volcano, Nicaragua

    NASA Astrophysics Data System (ADS)

    van Wyk de Vries, Benjamin; Navarro, Martha; Espinoza, Eveling; Delgado, Hugo

    2017-04-01

    The Momotombo volcano has a special place in the history of Nicaragua. It is perfectly visible from the Capital, Managua, and from the major city of Leon. The old capital "Leon Viejo", founded in 1524 was abandoned in 1610, after a series of earthquakes and some major eruptions from Momotombo. The site was subsequently covered by Momotombo ash. A major geothermal power plant stands at the base of the volcano. Momotombo had been dormant for a hundred years, but had maintained high fumarole temperatures (900°C), indicating magma had been close to the surface for decades. In recent years, seismic activity has increased around the volcano. In December 2015, after a short ash eruption phase the volcano erupted lava, then a string of Vulcanian explosions. The volcano is now in a phase of small Vulcanian explosions and degassing. The Leon Viejo World Heritage site is at risk to mainly ash fall from the volcano, but the abandonment of the old city was primarily due to earthquakes. Additional risks come from high rainfall during hurricanes. There is an obvious link between the cultural site (inscribed under UNESCO cultural criteria) and the geological environment. First, the reactivation of Momotombo volcano makes it more important to revise the hazard of the site. At the same time, Leon Viejo can provide a portal for outreach related to the volcano and for geological risk in general. To maximise this, we provide a geosite inventory of the main features of Momotombo, and it's environs, that can be used as the first base for such studies. The volcano was visited by many adventure tourists before the 2015/2016 eruption, but is out of bounds at present. Alternative routes, around the volcano could be made, to adapt to the new situation and to show to visitors more of the geodiversity of this fascinating volcano-tectonic and cultural area.

  13. Risk in the "Red Zone": Outcomes for Children Admitted to Ebola Holding Units in Sierra Leone Without Ebola Virus Disease.

    PubMed

    Fitzgerald, F; Wing, K; Naveed, A; Gbessay, M; Ross, J C G; Checchi, F; Youkee, D; Jalloh, M B; Baion, D; Mustapha, A; Jah, H; Lako, S; Oza, S; Boufkhed, S; Feury, R; Bielicki, J; Williamson, E; Gibb, D M; Klein, N; Sahr, F; Yeung, S

    2017-07-01

    We collected data on 1054 children admitted to Ebola Holding Units in Sierra Leone and describe outcomes of 697/1054 children testing negative for Ebola virus disease (EVD) and accompanying caregivers. Case-fatality was 9%; 3/630 (0.5%) children discharged testing negative were readmitted EVD-positive. Nosocomial EVD transmission risk may be lower than feared. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

  14. Characterization of the dengue outbreak in Nuevo Leon state, Mexico, 2010.

    PubMed

    Leduc-Galindo, D; Gloria-Herrera, U; Rincón-Herrera, U; Ramos-Jiménez, J; Garcia-Luna, S; Arellanos-Soto, D; Mendoza-Tavera, N; Tavitas-Aguilar, I; Garcia-Garcia, E; Galindo-Galindo, E; Villarreal-Perez, J; Fernandez-Salas, I; Santiago, G A; Muñoz-Jordan, J; Rivas-Estilla, A M

    2015-04-01

    We studied serotypes circulating dengue virus (DENV) cases, entomological Breteau index, rain-fall index and epidemiology of groups affected during the 2010 outbreak in Nuevo Leon, Mexico. From 2,271 positive cases, 94% were dengue classic and 6% dengue hemorrhagic fever; DENV1 was mainly isolated (99%) (Central-American lineage of American-African-genotype). We found correlation between two environmental phenomena (Increment of rainfall and vector-indexes) (p ≤ 0.05) with epidemiological, clinical and risk of DENV-1 ongoing transmission.

  15. Undiagnosed Acute Viral Febrile Illnesses, Sierra Leone

    PubMed Central

    Rossi, Cynthia A.; Khan, Sheik H.; Goba, Augustine; Fair, Joseph N.

    2014-01-01

    Sierra Leone in West Africa is in a Lassa fever–hyperendemic region that also includes Guinea and Liberia. Each year, suspected Lassa fever cases result in submission of ≈500–700 samples to the Kenema Government Hospital Lassa Diagnostic Laboratory in eastern Sierra Leone. Generally only 30%–40% of samples tested are positive for Lassa virus (LASV) antigen and/or LASV-specific IgM; thus, 60%–70% of these patients have acute diseases of unknown origin. To investigate what other arthropod-borne and hemorrhagic fever viral diseases might cause serious illness in this region and mimic Lassa fever, we tested patient serum samples that were negative for malaria parasites and LASV. Using IgM-capture ELISAs, we evaluated samples for antibodies to arthropod-borne and other hemorrhagic fever viruses. Approximately 25% of LASV-negative patients had IgM to dengue, West Nile, yellow fever, Rift Valley fever, chikungunya, Ebola, and Marburg viruses but not to Crimean-Congo hemorrhagic fever virus. PMID:24959946

  16. Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone

    PubMed Central

    Park, Daniel J.; Dudas, Gytis; Wohl, Shirlee; Goba, Augustine; Whitmer, Shannon L.M.; Andersen, Kristian G.; Sealfon, Rachel S.; Ladner, Jason T.; Kugelman, Jeffrey R.; Matranga, Christian B.; Winnicki, Sarah M.; Qu, James; Gire, Stephen K.; Gladden-Young, Adrianne; Jalloh, Simbirie; Nosamiefan, Dolo; Yozwiak, Nathan L.; Moses, Lina M.; Jiang, Pan-Pan; Lin, Aaron E.; Schaffner, Stephen F.; Bird, Brian; Towner, Jonathan; Mamoh, Mambu; Gbakie, Michael; Kanneh, Lansana; Kargbo, David; Massally, James L.B.; Kamara, Fatima K.; Konuwa, Edwin; Sellu, Josephine; Jalloh, Abdul A.; Mustapha, Ibrahim; Foday, Momoh; Yillah, Mohamed; Erickson, Bobbie R.; Sealy, Tara; Blau, Dianna; Paddock, Christopher; Brault, Aaron; Amman, Brian; Basile, Jane; Bearden, Scott; Belser, Jessica; Bergeron, Eric; Campbell, Shelley; Chakrabarti, Ayan; Dodd, Kimberly; Flint, Mike; Gibbons, Aridth; Goodman, Christin; Klena, John; McMullan, Laura; Morgan, Laura; Russell, Brandy; Salzer, Johanna; Sanchez, Angela; Wang, David; Jungreis, Irwin; Tomkins-Tinch, Christopher; Kislyuk, Andrey; Lin, Michael F.; Chapman, Sinead; MacInnis, Bronwyn; Matthews, Ashley; Bochicchio, James; Hensley, Lisa E.; Kuhn, Jens H.; Nusbaum, Chad; Schieffelin, John S.; Birren, Bruce W.; Forget, Marc; Nichol, Stuart T.; Palacios, Gustavo F.; Ndiaye, Daouda; Happi, Christian; Gevao, Sahr M.; Vandi, Mohamed A.; Kargbo, Brima; Holmes, Edward C.; Bedford, Trevor; Gnirke, Andreas; Ströher, Ute; Rambaut, Andrew; Garry, Robert F.; Sabeti, Pardis C.

    2015-01-01

    Summary The 2013–2015 Ebola virus disease (EVD) epidemic is caused by the Makona variant of Ebola virus (EBOV). Early in the epidemic, genome sequencing provided insights into virus evolution and transmission and offered important information for outbreak response. Here, we analyze sequences from 232 patients sampled over 7 months in Sierra Leone, along with 86 previously released genomes from earlier in the epidemic. We confirm sustained human-to-human transmission within Sierra Leone and find no evidence for import or export of EBOV across national borders after its initial introduction. Using high-depth replicate sequencing, we observe both host-to-host transmission and recurrent emergence of intrahost genetic variants. We trace the increasing impact of purifying selection in suppressing the accumulation of nonsynonymous mutations over time. Finally, we note changes in the mucin-like domain of EBOV glycoprotein that merit further investigation. These findings clarify the movement of EBOV within the region and describe viral evolution during prolonged human-to-human transmission. PMID:26091036

  17. Control of Ebola hemorrhagic fever: vaccine development and our Ebola project in Sierra Leone.

    PubMed

    Watanabe, Tokiko; Kawaoka, Yoshihiro

    2016-01-01

    Since December 2013, West Africa has experienced the worst Ebola virus outbreak in recorded history. Of the 28,639 cases reported to the World Health Organization as of March 2016, nearly half (14,124) occurred in Sierra Leone. With a case fatality rate of approximately 40%, this outbreak has claimed the lives of 11,316 individuals. No FDA-approved vaccines or drugs are available to prevent or treat Ebola virus infection. Experimental vaccines and therapies are being developed; however, their safety and efficacy are still being evaluated. Therefore, there is an urgent need to develop control measures to prevent or limit future Ebola virus outbreaks.Previously, we developed a replication-defective Ebola virus that lacks the coding region for the essential viral transcription activator VP30 (Ebola ΔVP30 virus). Here, we evaluated the vaccine efficacy of Ebola ΔVP30 virus in a non-human primate model and describe our collaborative Ebola project in Sierra Leone.

  18. Performance analysis of the GR712RC dual-core LEON3FT SPARC V8 processor in an asymmetric multi-processing environment

    NASA Astrophysics Data System (ADS)

    Giusi, Giovanni; Liu, Scige J.; Galli, Emanuele; Di Giorgio, Anna M.; Farina, Maria; Vertolli, Nello; Di Lellis, Andrea M.

    2016-07-01

    In this paper we present the results of a series of performance tests carried out on a prototype board mounting the Cobham Gaisler GR712RC Dual Core LEON3FT processor. The aim was the characterization of the performances of the dual core processor when used for executing a highly demanding lossless compression task, acting on data segments continuously copied from the static memory to the processor RAM. The selection of the compression activity to evaluate the performances was driven by the possibility of a comparison with previously executed tests on the Cobham/Aeroflex Gaisler UT699 LEON3FT SPARC™ V8. The results of the test activity have shown a factor 1.6 of improvement with respect to the previous tests, which can easily be improved by adopting a faster onboard board clock, and provided indications on the best size of the data chunks to be used in the compression activity.

  19. Strengthening Health Systems While Responding to a Health Crisis: Lessons Learned by a Nongovernmental Organization During the Ebola Virus Disease Epidemic in Sierra Leone

    PubMed Central

    Cancedda, Corrado; Davis, Sheila M.; Dierberg, Kerry L.; Lascher, Jonathan; Kelly, J. Daniel; Barrie, Mohammed Bailor; Koroma, Alimamy Philip; George, Peter; Kamara, Adikali Alpha; Marsh, Ronald; Sumbuya, Manso S.; Nutt, Cameron T.; Scott, Kirstin W.; Thomas, Edgar; Bollbach, Katherine; Sesay, Andrew; Barrie, Ahmidu; Barrera, Elizabeth; Barron, Kathryn; Welch, John; Bhadelia, Nahid; Frankfurter, Raphael G.; Dahl, Ophelia M.; Das, Sarthak; Rollins, Rebecca E.; Eustis, Bryan; Schwartz, Amanda; Pertile, Piero; Pavlopoulos, Ilias; Mayfield, Allan; Marsh, Regan H.; Dibba, Yusupha; Kloepper, Danielle; Hall, Andrew; Huster, Karin; Grady, Michael; Spray, Kimberly; Walton, David A.; Daboh, Fodei; Nally, Cora; James, Sahr; Warren, Gabriel S.; Chang, Joyce; Drasher, Michael; Lamin, Gina; Bangura, Sherry; Miller, Ann C.; Michaelis, Annie P.; McBain, Ryan; Broadhurst, M. Jana; Murray, Megan; Richardson, Eugene T.; Philip, Ted; Gottlieb, Gary L.; Mukherjee, Joia S.; Farmer, Paul E.

    2016-01-01

    An epidemic of Ebola virus disease (EVD) beginning in 2013 has claimed an estimated 11 310 lives in West Africa. As the EVD epidemic subsides, it is important for all who participated in the emergency Ebola response to reflect on strengths and weaknesses of the response. Such reflections should take into account perspectives not usually included in peer-reviewed publications and after-action reports, including those from the public sector, nongovernmental organizations (NGOs), survivors of Ebola, and Ebola-affected households and communities. In this article, we first describe how the international NGO Partners In Health (PIH) partnered with the Government of Sierra Leone and Wellbody Alliance (a local NGO) to respond to the EVD epidemic in 4 of the country's most Ebola-affected districts. We then describe how, in the aftermath of the epidemic, PIH is partnering with the public sector to strengthen the health system and resume delivery of regular health services. PIH's experience in Sierra Leone is one of multiple partnerships with different stakeholders. It is also one of rapid deployment of expatriate clinicians and logistics personnel in health facilities largely deprived of health professionals, medical supplies, and physical infrastructure required to deliver health services effectively and safely. Lessons learned by PIH and its partners in Sierra Leone can contribute to the ongoing discussion within the international community on how to ensure emergency preparedness and build resilient health systems in settings without either. PMID:27688219

  20. Tertiary carbonate-dissolution cycles on the Sierra Leone Rise, eastern equatorial Atlantic Ocean

    USGS Publications Warehouse

    Dean, W.E.; Gardner, J.V.; Cepek, P.

    1981-01-01

    Most of the Tertiary section on Sierra Leone Rise off northwest Africa consists of chalk, marl, and limestone that show cyclic alterations of clay-rich and clay-poor beds about 20-60 cm thick. On the basis of biostratigraphic accumulation rates, the cycles in Oligocene and Miocene chalk have periods which average about 44,000 years, and those in Eocene siliceous limestone have periods of 4000-27,000 years. Several sections were sampled in detail to further define the cycles in terms of content of CaCO3, clay minerals, and relative abundances of calcareous nannofossils. Extending information gained by analyses of Pleistocene cores from the continental margin of northwest Africa to the Tertiary cycles on Sierra Leone Rise, both dilution by noncarbonate material and dissolution of CaCO3 could have contributed to the observed relative variations in clay and CaCO3. However, dissolution of CaCO3 as the main cause of the carbonate-clay cycles on the Sierra Leone Rise, rather than dilution by clay, is suggested by the large amount of change (several thousand percent) in terrigenous influx required to produce the observed variations in amount of clay and by the marked increase in abundance of dissolution-resistant discoasters relative to more easily dissolved coccoliths in low-carbonate parts of cycles. The main cause of dissolution of CaCO3 was shoaling of the carbonate compensation depth (CCD) during the early Neogene and climatically induced fluctuations in the thickness of Antarctic Bottom Water. ?? 1981.

  1. Potential human health risk by 234,238U and 210Po due to consumption of fish from the "Luis L. Leon" reservoir (Northern Mexico)

    NASA Astrophysics Data System (ADS)

    Luna-Porres, M. Y.; Rodríguez-Villa, M. A.; Herrera-Peraza, E.; Cabral-Lares, M.; Renteria-Villalobos, M.; Montero-Cabrera, M. E.

    2014-07-01

    The Conchos River is one of the most important in northern Mexico and the main surface waterway in the arid state of Chihuahua. The Luis L. Leon dam produces the Luis L. Leon Reservoir, which is the last major reservoir before the Conchos River enters the Rio Grande at the Texas-Chihuahua border. Activity concentrations (AC) of 234,238U and 210Po in fillet and liver of three stocked fish species (Lepomis cyanellus, Cyprinus carpio and Ictalurus furcatus), as well as in water from the Luis L. Leon reservoir were determined. 238U and 234U ACs in fillet samples showed values of 0.007-0.014 and 0.01-0.02 Bq kg-1 wet weight (ww), respectively. Liver samples for Lepomis cyanellus, Cyprinus carpio and Ictalurus furcatus species, present 210Po AC of 1.16-3.26 0.70-1.13 and 0.93-1.37 Bqṡkg-1 ww. The elemental Bioaccumulation Factor (BAF) for fish tissues respect to their concentrations in water was determined. Lepomis cyanellus species showed the highest BAF for total uranium in fillet, with value 1.5. The annual effective dose for uranium in adults by fish consumption in this work ranged from 4.46×10-3 to 3.68×10-2 μSvṡyear-1. The difference in concentrations of uranium in fillet among the studied species is likely primarily due to their differences in diet and habitat.

  2. American Colony in Africa: Lessons Learned from Other Former Colonial Powers in West Africa That Can Be Applied to the United States’ Relationship with Liberia

    DTIC Science & Technology

    2016-06-10

    ultimate success or failure of Liberia in post -colonial Africa. Liberia’s three neighboring countries: Côte d’Ivoire, Sierra Leone, and Guinea all...Liberia in post -colonial Africa. Liberia’s three neighboring countries: Côte d’Ivoire, Sierra Leone, and Guinea all have unique relationships with...between Liberia and the US, both countries have had significant issues defining their post -colonial relationship with each other. Though the US has many

  3. Detection of a typhus group Rickettsia in Amblyomma ticks in the state of Nuevo Leon, Mexico.

    PubMed

    Medina-Sanchez, Aaron; Bouyer, Donald H; Alcantara-Rodriguez, Virginia; Mafra, Claudio; Zavala-Castro, Jorge; Whitworth, Ted; Popov, Vsevolod L; Fernandez-Salas, Ildefonso; Walker, David H

    2005-12-01

    The state of Nuevo Leon, Mexico has had outbreaks of typhus group rickettsiosis, most recently recognized in 1997. Evaluation of the sera of 345 patients with a dengue-like illness revealed that 25.5% had antibodies reactive with typhus group rickettsiae and 16% had antibodies to Rickettsia parkeri. Rickettsiae were detected by PCR and shell-vial isolations in the field-collected Amblyomma ticks. Molecular characterization by DNA sequence analysis of the gltA, ompB, and 17-kDa gene identified the organisms to be R. prowazekii.

  4. Maternal health, war, and religious tradition: authoritative knowledge in Pujehun District, Sierra Leone.

    PubMed

    Jambai, A; MacCormack, C

    1996-06-01

    In Sierra Leone constraints to ideal maternal health require a primary health care approach that includes collaboration with traditional midwives. They are authoritative figures embedded within local political structures and a powerful women's religion. The local causes of maternal risk are described, including civil war and refugee camp life. Traditional midwives provide vital services in the camp, are respected for their social status, and learn additional skills. Biomedical and traditional systems of authoritative knowledge, based on different kinds of legitimacy to heal, are in a complementary relationship.

  5. Border Environmental Education Resource Guide: Southern New Mexico, South Texas, Northern Chihuahua, Northern Coahuila, Northern Nuevo Leon, Northern Tamaulipas = Guia de Recursos de Educacion Ambiental en la Frontera: Sur de Nuevo Mexico, Sur de Texas, Norte de Chihuahua, Norte de Coahuila, Norte de Nuevo Leon, Norte de Tamaulipas.

    ERIC Educational Resources Information Center

    Meissner, David, Comp.

    This guide provides educators and residents of the border with useful information about environmental education program offerings along the eastern half of the United States-Mexico border. The programs listed in the guide represent a broad range of educational efforts focused on understanding the environment and solving environmental problems in…

  6. Modeling the 2014 Ebola Virus Epidemic - Agent-Based Simulations, Temporal Analysis and Future Predictions for Liberia and Sierra Leone.

    PubMed

    Siettos, Constantinos; Anastassopoulou, Cleo; Russo, Lucia; Grigoras, Christos; Mylonakis, Eleftherios

    2015-03-09

    We developed an agent-based model to investigate the epidemic dynamics of Ebola virus disease (EVD) in Liberia and Sierra Leone from May 27 to December 21, 2014. The dynamics of the agent-based simulator evolve on small-world transmission networks of sizes equal to the population of each country, with adjustable densities to account for the effects of public health intervention policies and individual behavioral responses to the evolving epidemic. Based on time series of the official case counts from the World Health Organization (WHO), we provide estimates for key epidemiological variables by employing the so-called Equation-Free approach. The underlying transmission networks were characterized by rather random structures in the two countries with densities decreasing by ~19% from the early (May 27-early August) to the last period (mid October-December 21). Our estimates for the values of key epidemiological variables, such as the mean time to death, recovery and the case fatality rate, are very close to the ones reported by the WHO Ebola response team during the early period of the epidemic (until September 14) that were calculated based on clinical data. Specifically, regarding the effective reproductive number Re, our analysis suggests that until mid October, Re was above 2.3 in both countries; from mid October to December 21, Re dropped well below unity in Liberia, indicating a saturation of the epidemic, while in Sierra Leone it was around 1.9, indicating an ongoing epidemic. Accordingly, a ten-week projection from December 21 estimated that the epidemic will fade out in Liberia in early March; in contrast, our results flashed a note of caution for Sierra Leone since the cumulative number of cases could reach as high as 18,000, and the number of deaths might exceed 5,000, by early March 2015. However, by processing the reported data of the very last period (December 21, 2014-January 18, 2015), we obtained more optimistic estimates indicative of a remission of the epidemic in Sierra Leone, as reflected by the derived Re (~0.82, 95% CI: 0.81-0.83).

  7. Evaluating the use of cell phone messaging for community Ebola syndromic surveillance in high risked settings in Southern Sierra Leone.

    PubMed

    Jia, Kangbai; Mohamed, Koroma

    2015-09-01

    Most underdeveloped countries do not meet core disease outbreak surveillance because of the lack of human resources, laboratory and infrastructural facilities. The use of cell phone technology for disease outbreak syndromic surveillance is a new phenomenon in Sierra Leone despite its successes in other developing countries like Sri Lanka. In this study we set to evaluate the effectiveness of using cell phone technology for Ebola hemorrhagic fever syndromic surveillance in a high risked community in Sierra Leone. This study evaluated the effectiveness of using cell phone messaging (text and calls) for community Ebola hemorrhagic fever syndromic surveillance in high risked community in southern Sierra Leone. All cell phone syndromic surveillance data used for this study was reported as cell phone alert messages-texts and voice calls; by the Moyamba District Health Management Team for both Ebola hemorrhagic fever suspect and mortalities. We conducted a longitudinal data analysis of the monthly cumulative confirmed Ebola hemorrhagic fever cases and mortalities collected by both the traditional sentinel and community cell phone syndromic surveillance from August 2014 to October 2014. A total of 129 and 49 Ebola hemorrhagic fever suspect and confirmed cases respectively were recorded using the community Ebola syndromic surveillance cell phone alert system by the Moyamba District Health Management Team in October 2014. The average number of Ebola hemorrhagic fever suspects and confirmed cases for October 2014 were 4.16 (Std.dev 3.76) and 1.58 (Std.dev 1.43) respectively. Thirty-four percent (n=76) of the community Ebola syndromic surveillance cell phone alerts that were followed-up within 24 hours reported Ebola hemorrhagic fever suspect cases while 65.92% (n=147) reported mortality. Our study suggests some form of underreporting by the traditional sentinel Ebola hemorrhagic fever disease surveillance system in Moyamba District southern Sierra Leone for August-September 2014. Cell phone messaging technology can be effectively use as a tool for community epidemic surveillance from peripheral health care facilities to higher levels.

  8. [Western area surge for controlling Ebola hemorrhagic fever outbreak in Sierra Leone and evaluation of its effect].

    PubMed

    Chen, Yong; Wu, Dan; Zhang, Wenyi; Chen, Zeliang; Chang, Guohui; Tian, Shuguang; Yang, Ruifu; Liu, Chao

    2015-10-01

    To investigate the Western Area Surge (WAS) program in the Ebola outbreak of Sierra Leone, and to analyze its implementing effect. The subject of this study was 3,813 laboratory confirmed Ebola hemorrhagic fever (EHF) cases reported in Sierra Leone from November 19, 2014 through January 27, 2015, a period before and after the implementation of the WAS program. To analyze and make conclusions according to the working experience of China Mobile Laboratory Reponses Team in the fight of Ebola outbreak, using WHO published EHF case definition to make diagnosis and compare the number of bed numbers, confirmed EHF cases, samples tested, and positive rates before and after implementation of WAS program. From the implementation of WAS program on 17th December 2014 to half a month later, the total numbers of Ebola holding and treatment centers increased from 640 to 960, six additional laboratories were established. On January, 2015, another two laboratories from America and The Netherlands were established. The numbers of samples tested one month before and after WAS program were 7,891 and 9,783, respectively, with an increase of 24.0 percent, while the positive rate of Ebola virus decreased from 22.2% (1,752/7,891) to 11.0% (1,077/9,783). The positive rate of blood samples decreased from 39.6% (248/626) in the month before WAS program to 27.4% (131/478) (χ2=17.93, P<0.001) in the mother after WAS program, the positive rate of blood samples 22.7% (103/454) to 10% (62/609) (χ2=31.03, P<0.001), accordingly. After 3 weeks of WAS program, in addition to Western Area, another four hotspots in Sierra Leone had also reported a significant decrease of the numbers of confirmed EVD cases. Forty-two days after implementation of WAS program, the daily number of laboratory confirmed EHF cases decreased from 63 to 10. WAS program played a vital role in controlling the EHF outbreak rapidly in Sierra Leone. It could also provide guidance for the control similar large infectious diseases outbreak in the future.

  9. Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone.

    PubMed

    Tong, Yi-Gang; Shi, Wei-Feng; Liu, Di; Qian, Jun; Liang, Long; Bo, Xiao-Chen; Liu, Jun; Ren, Hong-Guang; Fan, Hang; Ni, Ming; Sun, Yang; Jin, Yuan; Teng, Yue; Li, Zhen; Kargbo, David; Dafae, Foday; Kanu, Alex; Chen, Cheng-Chao; Lan, Zhi-Heng; Jiang, Hui; Luo, Yang; Lu, Hui-Jun; Zhang, Xiao-Guang; Yang, Fan; Hu, Yi; Cao, Yu-Xi; Deng, Yong-Qiang; Su, Hao-Xiang; Sun, Yu; Liu, Wen-Sen; Wang, Zhuang; Wang, Cheng-Yu; Bu, Zhao-Yang; Guo, Zhen-Dong; Zhang, Liu-Bo; Nie, Wei-Min; Bai, Chang-Qing; Sun, Chun-Hua; An, Xiao-Ping; Xu, Pei-Song; Zhang, Xiang-Li-Lan; Huang, Yong; Mi, Zhi-Qiang; Yu, Dong; Yao, Hong-Wu; Feng, Yong; Xia, Zhi-Ping; Zheng, Xue-Xing; Yang, Song-Tao; Lu, Bing; Jiang, Jia-Fu; Kargbo, Brima; He, Fu-Chu; Gao, George F; Cao, Wu-Chun

    2015-08-06

    A novel Ebola virus (EBOV) first identified in March 2014 has infected more than 25,000 people in West Africa, resulting in more than 10,000 deaths. Preliminary analyses of genome sequences of 81 EBOV collected from March to June 2014 from Guinea and Sierra Leone suggest that the 2014 EBOV originated from an independent transmission event from its natural reservoir followed by sustained human-to-human infections. It has been reported that the EBOV genome variation might have an effect on the efficacy of sequence-based virus detection and candidate therapeutics. However, only limited viral information has been available since July 2014, when the outbreak entered a rapid growth phase. Here we describe 175 full-length EBOV genome sequences from five severely stricken districts in Sierra Leone from 28 September to 11 November 2014. We found that the 2014 EBOV has become more phylogenetically and genetically diverse from July to November 2014, characterized by the emergence of multiple novel lineages. The substitution rate for the 2014 EBOV was estimated to be 1.23 × 10(-3) substitutions per site per year (95% highest posterior density interval, 1.04 × 10(-3) to 1.41 × 10(-3) substitutions per site per year), approximating to that observed between previous EBOV outbreaks. The sharp increase in genetic diversity of the 2014 EBOV warrants extensive EBOV surveillance in Sierra Leone, Guinea and Liberia to better understand the viral evolution and transmission dynamics of the ongoing outbreak. These data will facilitate the international efforts to develop vaccines and therapeutics.

  10. Population mobility reductions associated with travel restrictions during the Ebola epidemic in Sierra Leone: use of mobile phone data.

    PubMed

    Peak, Corey M; Wesolowski, Amy; Zu Erbach-Schoenberg, Elisabeth; Tatem, Andrew J; Wetter, Erik; Lu, Xin; Power, Daniel; Weidman-Grunewald, Elaine; Ramos, Sergio; Moritz, Simon; Buckee, Caroline O; Bengtsson, Linus

    2018-06-26

    Travel restrictions were implementeded on an unprecedented scale in 2015 in Sierra Leone to contain and eliminate Ebola virus disease. However, the impact of epidemic travel restrictions on mobility itself remains difficult to measure with traditional methods. New 'big data' approaches using mobile phone data can provide, in near real-time, the type of information needed to guide and evaluate control measures. We analysed anonymous mobile phone call detail records (CDRs) from a leading operator in Sierra Leone between 20 March and 1 July in 2015. We used an anomaly detection algorithm to assess changes in travel during a national 'stay at home' lockdown from 27 to 29 March. To measure the magnitude of these changes and to assess effect modification by region and historical Ebola burden, we performed a time series analysis and a crossover analysis. Routinely collected mobile phone data revealed a dramatic reduction in human mobility during a 3-day lockdown in Sierra Leone. The number of individuals relocating between chiefdoms decreased by 31% within 15 km, by 46% for 15-30 km and by 76% for distances greater than 30 km. This effect was highly heterogeneous in space, with higher impact in regions with higher Ebola incidence. Travel quickly returned to normal patterns after the restrictions were lifted. The effects of travel restrictions on mobility can be large, targeted and measurable in near real-time. With appropriate anonymization protocols, mobile phone data should play a central role in guiding and monitoring interventions for epidemic containment.

  11. Rapid assessment of Ebola infection prevention and control needs--six districts, Sierra Leone, October 2014.

    PubMed

    Pathmanathan, Ishani; O'Connor, Katherine A; Adams, Monica L; Rao, Carol Y; Kilmarx, Peter H; Park, Benjamin J; Mermin, Jonathan; Kargbo, Brima; Wurie, Alie H; Clarke, Kevin R

    2014-12-12

    As of October 31, 2014, the Sierra Leone Ministry of Health and Sanitation had reported 3,854 laboratory-confirmed cases of Ebola virus disease (Ebola) since the outbreak began in May 2014; 199 (5.2%) of these cases were among health care workers. Ebola infection prevention and control (IPC) measures are essential to interrupt Ebola virus transmission and protect the health workforce, a population that is disproportionately affected by Ebola because of its increased risk of exposure yet is essential to patient care required for outbreak control and maintenance of the country's health system at large. To rapidly identify existing IPC resources and high priority outbreak response needs, an assessment by CDC Ebola Response Team members was conducted in six of the 14 districts in Sierra Leone, consisting of health facility observations and structured interviews with key informants in facilities and government district health management offices. Health system gaps were identified in all six districts, including shortages or absence of trained health care staff, personal protective equipment (PPE), safe patient transport, and standardized IPC protocols. Based on rapid assessment findings and key stakeholder input, priority IPC actions were recommended. Progress has since been made in developing standard operating procedures, increasing laboratory and Ebola treatment capacity and training the health workforce. However, further system strengthening is needed. In particular, a successful Ebola outbreak response in Sierra Leone will require an increase in coordinated and comprehensive district-level IPC support to prevent ongoing Ebola virus transmission in household, patient transport, and health facility settings.

  12. Uranium series isotopes concentration in sediments at San Marcos and Luis L. Leon reservoirs, Chihuahua, Mexico

    NASA Astrophysics Data System (ADS)

    Méndez-García, C.; Renteria-Villalobos, M.; García-Tenorio, R.; Montero-Cabrera, M. E.

    2014-07-01

    Spatial and temporal distribution of the radioisotopes concentrations were determined in sediments near the surface and core samples extracted from two reservoirs located in an arid region close to Chihuahua City, Mexico. At San Marcos reservoir one core was studied, while from Luis L. Leon reservoir one core from the entrance and another one close to the wall were investigated. 232Th-series, 238U-series, 40K and 137Cs activity concentrations (AC, Bq kg-1) were determined by gamma spectrometry with a high purity Ge detector. 238U and 234U ACs were obtained by liquid scintillation and alpha spectrometry with a surface barrier detector. Dating of core sediments was performed applying CRS method to 210Pb activities. Results were verified by 137Cs AC. Resulting activity concentrations were compared among corresponding surface and core sediments. High 238U-series AC values were found in sediments from San Marcos reservoir, because this site is located close to the Victorino uranium deposit. Low AC values found in Luis L. Leon reservoir suggest that the uranium present in the source of the Sacramento - Chuviscar Rivers is not transported up to the Conchos River. Activity ratios (AR) 234U/overflow="scroll">238U and 238U/overflow="scroll">226Ra in sediments have values between 0.9-1.2, showing a behavior close to radioactive equilibrium in the entire basin. 232Th/overflow="scroll">238U, 228Ra/overflow="scroll">226Ra ARs are witnesses of the different geological origin of sediments from San Marcos and Luis L. Leon reservoirs.

  13. Support services for survivors of ebola virus disease - Sierra Leone, 2014.

    PubMed

    Lee-Kwan, Seung Hee; DeLuca, Nickolas; Adams, Monica; Dalling, Matthew; Drevlow, Elizabeth; Gassama, Gladys; Davies, Tina

    2014-12-19

    As of December 6, 2014, Sierra Leone reported 6,317 laboratory-confirmed cases of Ebola virus disease (Ebola), the highest number of reported cases in the current West Africa epidemic. The Sierra Leone Ministry of Health and Sanitation reported that as of December 6, 2014, there were 1,181 persons who had survived and were discharged. Survivors from previous Ebola outbreaks have reported major barriers to resuming normal lives after release from treatment, such as emotional distress, health issues, loss of possessions, and difficulty regaining their livelihoods. In August 2014, a knowledge, attitude, and practice survey regarding the Ebola outbreak in Sierra Leone, administered by a consortium of partners that included the Ministry of Health and Sanitation, UNICEF, CDC, and a local nongovernmental organization, Focus 1000, found that 96% of the general population respondents reported some discriminatory attitude towards persons with suspected or known Ebola. Access to increased psychosocial support, provision of goods, and family and community reunification programs might reduce these barriers. Survivors also have unique potential to contribute to the Ebola response, particularly because survivors might have some immunity to the same virus strain. In previous outbreaks, survivors served as burial team members, contact tracers, and community educators promoting messages that seeking treatment improves the chances for survival and that persons who survived Ebola can help their communities. As caregivers in Ebola treatment units, survivors have encouraged patients to stay hydrated and eat and inspired them to believe that they, too, can survive. Survivors regaining livelihood through participation in the response might offset the stigma associated with Ebola.

  14. Strengthening Health Systems While Responding to a Health Crisis: Lessons Learned by a Nongovernmental Organization During the Ebola Virus Disease Epidemic in Sierra Leone.

    PubMed

    Cancedda, Corrado; Davis, Sheila M; Dierberg, Kerry L; Lascher, Jonathan; Kelly, J Daniel; Barrie, Mohammed Bailor; Koroma, Alimamy Philip; George, Peter; Kamara, Adikali Alpha; Marsh, Ronald; Sumbuya, Manso S; Nutt, Cameron T; Scott, Kirstin W; Thomas, Edgar; Bollbach, Katherine; Sesay, Andrew; Barrie, Ahmidu; Barrera, Elizabeth; Barron, Kathryn; Welch, John; Bhadelia, Nahid; Frankfurter, Raphael G; Dahl, Ophelia M; Das, Sarthak; Rollins, Rebecca E; Eustis, Bryan; Schwartz, Amanda; Pertile, Piero; Pavlopoulos, Ilias; Mayfield, Allan; Marsh, Regan H; Dibba, Yusupha; Kloepper, Danielle; Hall, Andrew; Huster, Karin; Grady, Michael; Spray, Kimberly; Walton, David A; Daboh, Fodei; Nally, Cora; James, Sahr; Warren, Gabriel S; Chang, Joyce; Drasher, Michael; Lamin, Gina; Bangura, Sherry; Miller, Ann C; Michaelis, Annie P; McBain, Ryan; Broadhurst, M Jana; Murray, Megan; Richardson, Eugene T; Philip, Ted; Gottlieb, Gary L; Mukherjee, Joia S; Farmer, Paul E

    2016-10-15

    An epidemic of Ebola virus disease (EVD) beginning in 2013 has claimed an estimated 11 310 lives in West Africa. As the EVD epidemic subsides, it is important for all who participated in the emergency Ebola response to reflect on strengths and weaknesses of the response. Such reflections should take into account perspectives not usually included in peer-reviewed publications and after-action reports, including those from the public sector, nongovernmental organizations (NGOs), survivors of Ebola, and Ebola-affected households and communities. In this article, we first describe how the international NGO Partners In Health (PIH) partnered with the Government of Sierra Leone and Wellbody Alliance (a local NGO) to respond to the EVD epidemic in 4 of the country's most Ebola-affected districts. We then describe how, in the aftermath of the epidemic, PIH is partnering with the public sector to strengthen the health system and resume delivery of regular health services. PIH's experience in Sierra Leone is one of multiple partnerships with different stakeholders. It is also one of rapid deployment of expatriate clinicians and logistics personnel in health facilities largely deprived of health professionals, medical supplies, and physical infrastructure required to deliver health services effectively and safely. Lessons learned by PIH and its partners in Sierra Leone can contribute to the ongoing discussion within the international community on how to ensure emergency preparedness and build resilient health systems in settings without either. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.

  15. Housing equity for health equity: a rights-based approach to the control of Lassa fever in post-war Sierra Leone.

    PubMed

    Kelly, J Daniel; Barrie, M Bailor; Ross, Rachel A; Temple, Brian A; Moses, Lina M; Bausch, Daniel G

    2013-01-02

    Poor quality housing is an infringement on the rights of all humans to a standard of living adequate for health. Among the many vulnerabilities of those without adequate shelter is the risk of disease spread by rodents and other pests. One such disease is Lassa fever, an acute and sometimes severe viral hemorrhagic illness endemic in West Africa. Lassa virus is maintained in the rodent Mastomys natalensis, commonly known as the "multimammate rat," which frequently invades the domestic environment, putting humans at risk of Lassa fever. The highest reported incidence of Lassa fever in the world is consistently in the Kenema District of Sierra Leone, a region that was at the center of Sierra Leone's civil war in which tens of thousands of lives were lost and hundreds of thousands of dwellings destroyed. Despite the end of the war in 2002, most of Kenema's population still lives in inadequate housing that puts them at risk of rodent invasion and Lassa fever. Furthermore, despite years of health education and village hygiene campaigns, the incidence of Lassa fever in Kenema District appears to be increasing. We focus on Lassa fever as a matter of human rights, proposing a strategy to improve housing quality, and discuss how housing equity has the potential to improve health equity and ultimately economic productivity in Sierra Leone. The manuscript is designed to spur discussion and action towards provision of housing and prevention of disease in one of the world's most vulnerable populations.

  16. [Social and economic impact of chicken pox vaccine at 15 months of age. Castile and Leon, Spain, 2004].

    PubMed

    Pérez-Rubio, A; Castrodeza Sanz, J J; Gil Costa, M; Luquero Alcalde, F J; Eiros Bouza, J; Ortiz de Lejarazu, R

    2008-01-01

    Chicken pox is a mainly childhood contagious disease caused by the Varicella Zoster Virus which gives rise to major healthcare and social costs. In 2005, Castile and Leon added chicken pox vaccine injections to its childhood vaccination schedule for eleven year-olds subject to coming down with this disease. This strategy does not modify the major mobility generated thereby at younger ages. This study is aimed at evaluating the profitability of systematic vaccination for chicken pox in infants 15 months of age in Castile and Leon. An economic cost-benefit evaluation has been set out by jeans of a decision-making tree. A fictitious cohort of 100,000 children in Castile and Leon having reached 15 months of age in 2004 is studied, to whom the chicken pox vaccine would be administered in conjunction with the mumps, measles, rubella vaccines. This study is approached from the social standpoint. The time horizon selected was that of up until the study cohort was to reach 15 years of age, applying a 3% discount rate. A sensitivity analysis was made for evaluating the uncertainty of some variables... The cost-benefit ratio of adding this vaccine to the childhood vaccination schedule amounts to 1.23. From the social standpoint, administering chicken pox vaccine in conjunction with the mumps, measles, rubella vaccines show itself to be profitable. The profitability is modified both if a second dose of vaccine is added as well as if only the direct healthcare costs are analyzed.

  17. High and equitable mass vitamin A supplementation coverage in Sierra Leone: a post-event coverage survey.

    PubMed

    Hodges, Mary H; Sesay, Fatmata F; Kamara, Habib I; Turay, Mohamed; Koroma, Aminata S; Blankenship, Jessica L; Katcher, Heather I

    2013-08-01

    In Sierra Leone, children ages 6-59 months receive twice-yearly vitamin A supplementation (VAS) through Maternal and Child Health Week (MCHW) events. VAS coverage in 2011 was calculated using government tally sheets of vitamin A capsule distribution and outdated population projections from the 2004 census. We conducted a national post-event coverage (PEC) survey to validate coverage and inform strategies to reach universal coverage of VAS in Sierra Leone. Immediately following the November 2011 MCHW event, we conducted a national PEC survey by interviewing caregivers with children ages 6-59 months using a randomized 30X30 cluster design (N = 900). We also interviewed one health worker and one community health worker in each cluster to determine their knowledge about VAS (N = 60). VAS coverage was 91.8% among children ages 6-59 months, which was lower than the 105.1% reported through tally sheets. Coverage was high and equitable among all districts and between age groups (98.5% for infants ages 6-11 months and 90.5% for children ages 12-59 months). Major reasons for not receiving VAS were that the child was out of the area (42.4%), the household was not visited by community health workers (28.0%), and the caretaker was not aware of the event (11.9%). Twice-yearly delivery of VAS through MCHW events achieved consistently high and equitable coverage in Sierra Leone. Universal coverage may be achieved through continued focus on communication and targeted outreach to hard-to-reach areas during the MCHWs.

  18. The update of resist outgas testing for metal containing resists at EIDEC

    NASA Astrophysics Data System (ADS)

    Shiobara, Eishi; Mikami, Shinji

    2017-10-01

    The metal containing resist is one of the candidates for high sensitivity resists. EIDEC has prepared the infrastructure for outgas testing in hydrogen environment for metal containing resists at High Power EUV irradiation tool (HPEUV). We have experimentally obtained the preliminary results of the non-cleanable metal contamination on witness sample using model material by HPEUV [1]. The metal contamination was observed at only the condition of hydrogen environment. It suggested the generation of volatile metal hydrides by hydrogen radicals. Additionally, the metal contamination on a witness sample covered with Ru was not removed by hydrogen radical cleaning. The strong interaction between the metal hydride and Ru was confirmed by the absorption simulation. Recently, ASML announced a resist outgassing barrier technology using Dynamic Gas Lock (DGL) membrane located between projection optics and wafer stage [2], [3]. DGL membrane blocks the diffusion of all kinds of resist outgassing to the projection optics and prevents the reflectivity loss of EUV mirrors. The investigation of DGL membrane for high volume manufacturing is just going on. It extends the limitation of material design for EUV resists. However, the DGL membrane has an impact for the productivity of EUV scanners due to the transmission loss of EUV light and the necessity of periodic maintenance. The well understanding and control of the outgassing characteristics of metal containing resists may help to improve the productivity of EUV scanner. We consider the outgas evaluation for the resists still useful. For the improvement of resist outgas testing by HPEUV, there are some issues such as the contamination limited regime, the optimization of exposure dose to obtain the measurable contamination film thickness and the detection of minimum amount of metal related outgas species generated. The investigation and improvement for these issues are ongoing. The updates will be presented in the conference. This work was supported by Ministry of Economy, Trade and Industry (METI) and New Energy and Industrial Technology Development Organization (NEDO). [1] Eishi Shiobara, Shinji Mikami, Satoshi Tanaka, International Symposium on EUV Lithography, Hiroshima, Japan, P-RE-01, (2016). [2] Mark van de Kerkhof, Hans Jasper, Leon Levasier, Rudy Peeters, Roderik van Es, Jan-Willem Bosker, Alexander Zdravkov, Egbert Lenderink, Fabrizio Evangelista, Par Broman, Bartosz Bilski, Thorsten Last, Proc. of SPIE Vol. 10143, 101430D (2017). [3] Oktay Yildirim, Elizabeth Buitrago, Rik Hoefnagels, Marieke Meeuwissen, Sander Wuister, Gijsbert Rispens, Anton van Oosten, Paul Derks, Jo Finders, Michaela Vockenhuber, Yasin Ekinci, Proc. of SPIE Vol. 10143, 101430Q (2017).

  19. Survivors' perceptions of public health messages during an Ebola crisis in Liberia and Sierra Leone: An exploratory study.

    PubMed

    Schwerdtle, Patricia; De Clerck, Veronique; Plummer, Virginia

    2017-12-01

    The outbreak of Ebola virus disease in Guinea, Liberia, and Sierra Leone was the largest epidemic of Ebola ever recorded. The healthcare workforce was diminished and exhausted as the region emerged from civil war. Few qualitative, descriptive studies have been conducted to date that concentrate on the voices of Ebola survivors and their perceptions of health messages. In this study, we employed an interpretive, qualitative design to explore participant experiences. Twenty five survivors who had recovered from Ebola were recruited from three villages in Liberia and Sierra Leone in August 2015. Data were collected using semistructured interviews. Data analysis revealed four themes: (i) degrees of mistrust; (ii) messages conflicting with life and culture; (iii) seeing is believing; and (iv) recovery inspires hope. The findings were explored in the context of the relevant literature. The themes highlight the need to develop culturally-appropriate messages, underpinned by a sound understanding of the community and a willingness to work with the culture and trusted leaders. © 2017 John Wiley & Sons Australia, Ltd.

  20. Laryngologist Leon Zamenhof--brother of Dr. Esperanto.

    PubMed

    Wincewicz, Andrzej; Sulkowska, Mariola; Musiatowicz, Marcin; Sulkowski, Stanislaw

    2009-06-01

    To reconstruct the biography of the Polish otorhinolaryngologist Leon Zamenhof (1875-1934), a brother of Ludwik Zamenhof, who is famous for invention of the international language Esperanto. Biographical information was collected from pre-World War II resources. Zamenhof developed several important new forms of treatment to help the hearing impaired. Zamenhof was especially interested in the education of deaf children and the therapy necessary to facilitate their integration into society. His significant achievements were a phonetic method of therapy for the hearing impaired and an automatic device for ear insufflation that was considered indispensable in the management of pyorrhea. In addition, Zamenhof initiated various forms of social support among physicians within the medical community of Warsaw, Poland; made health care available to children with hearing impairments; and organized a Jewish school for deaf children. Zamenhof tried to change public attitudes toward deafness, working to promote the integration of the deaf into wider society. He also translated Polish literature into Esperanto. With similar aims to his brother Ludwik, Leon Zamenhof strived to enhance and broaden communication among people who could not hear and to persuade people to change their attitudes about deafness.

  1. Review: Leon N. Cooper's Science and Human Experience: Values, Culture, and the Mind.

    PubMed

    Lynch, Gary S

    2015-01-01

    Why are we reviewing a book written by someone who shared in the 1972 Nobel Prize in Physics for work on superconductivity? Because shortly after winning the prize, Leon N. Cooper transitioned into brain research-specifically, the biological basis of memory. He became director of the Brown University Institute for Brain and Neural Systems, whose interdisciplinary program allowed him to integrate research on the brain, physics, and even philosophy. His new book tackles a diverse spectrum of topics and questions, including these: Does science have limits? Where does order come from? Can we understand consciousness?

  2. Review: Leon N. Cooper’s Science and Human Experience: Values, Culture, and the Mind

    PubMed Central

    Lynch, Gary S.

    2015-01-01

    Why are we reviewing a book written by someone who shared in the 1972 Nobel Prize in Physics for work on superconductivity? Because shortly after winning the prize, Leon N. Cooper transitioned into brain research—specifically, the biological basis of memory. He became director of the Brown University Institute for Brain and Neural Systems, whose interdisciplinary program allowed him to integrate research on the brain, physics, and even philosophy. His new book tackles a diverse spectrum of topics and questions, including these: Does science have limits? Where does order come from? Can we understand consciousness? PMID:27358665

  3. The Ebola virus disease outbreak and the mineral sectors of Guinea, Liberia, and Sierra Leone

    USGS Publications Warehouse

    Bermúdez-Lugo, Omayra; Menzie, William D.

    2015-01-01

    In response to the uncertainty surrounding the status of mineral projects in Guinea, Liberia, and Sierra Leone, the National Minerals Information Center compiled information on the distribution of mines, mineral facilities, and mineral projects under development in the three countries. This fact sheet provides information on the role that the mineral sector plays in their respective economies, on the operating status of mining projects through yearend 2014, and on the coordinated actions by mining companies to support governments and international relief organizations in their efforts to contain the EVD outbreak.

  4. The Complex Kinematics of Galaxies in Hickson 67

    NASA Astrophysics Data System (ADS)

    Bettoni, D.; Buson, L. M.

    The kinematics of galaxies belonging to the Hickson compact group HCG67 are investigated. The latter consists of four galaxies, three of which (a, c, d) are embedded in a common envelope. The fourth galaxy (b) is a spiral that is detected both in radio and in IR wave-bands. Our observations show that the three galaxies in apparent interaction are probably caught during an ongoing merger process. Z Balcells, M., Morganti, R., Oosterloo, T., Peréz-Fournon, I. González Serrano, J. I. 1995, aap, 302, 665. Bertola, F., Bettoni, D., Rusconi, L., Sedmak, G. 1984, aj, 89, 356 Barnes, J. 1985, mnras, 215, 517 Hickson, P. 1982, apj, 255, 382 Hickson, P. 1993, Astrophys. Lett. Commun., 29, 1 Hickson, P., Menon, T. K., Palumbo, G. G. C., Persic, M. 1989, apj, 341,679 Leon, S., Combes, F., Menon, T. K. 1998, aap, 330, 37 Mamon, G. A. 1992, in "Physics of Nearby Galaxies: Nature or Nurture?", ed. T. X6. Thuan, C. Balkowski & Thran Thanh Van (12th Moriond Astrophysics Meeting)(Editions Frontiéres), p.367. Mendes de Oliveira, C., Hickson, P. 1991, apj, 380, 30 Mendes de Oliveira, C., Plana, H, Amram, P., Bolte, M., Boulesteix, J. 1998, apj, 507, 691 Menon, T. K. 1995, mnras, 274, 845 Rabaça, C. R., Sulentic, J. W. 1991, baas, 23, 1338 Zepf, S. E., Whitmore, B. C., Levison, H. F. 1991, apj, 383, 524

  5. Characterization of the hydrology, water chemistry, and aquatic communities of selected springs in the St. Johns River Water Management District, Florida, 2004

    USGS Publications Warehouse

    Phelps, G.G.; Walsh, Stephen J.; Gerwig, Robert M.; Tate, William B.

    2006-01-01

    The hydrology, water chemistry, and aquatic communities of Silver Springs, De Leon Spring, Gemini Springs, and Green Spring in the St. Johns River Water Management District, Florida, were studied in 2004 to provide a better understanding of each spring and to compile data of potential use in future water-management decisions. Ground water that discharges from these and other north-central Florida springs originates from the Upper Floridan aquifer of the Floridan aquifer system, a karstic limestone aquifer that extends throughout most of the State's peninsula. This report summarizes data about flow, water chemistry, and aquatic communities, including benthic invertebrates, fishes, algae, and aquatic macrophytes collected by the U.S. Geological Survey, the St. Johns River Water Management District, and the Florida Department of Environmental Protection during 2004, as well as some previously collected data. Differences in water chemistry among these springs reflect local differences in water chemistry in the Upper Floridan aquifer. The three major springs sampled at the Silver Springs group (the Main Spring, Blue Grotto, and the Abyss) have similar proportions of cations and anions but vary in nitrate and dissolved oxygen concentrations. Water from Gemini Springs and Green Spring has higher proportions of sodium and chloride than the Silver Springs group. Water from De Leon Spring also has higher proportions of sodium and chloride than the Silver Springs group but lower proportions of calcium and bicarbonate. Nitrate concentrations have increased over the period of record at all of the springs except Green Spring. Compounds commonly found in wastewater were found in all the springs sampled. The most commonly detected compound was the insect repellant N,N'-diethyl-methyl-toluamide (DEET), which was found in all the springs sampled except De Leon Spring. The pesticide atrazine and its degradate 2-chloro-4-isopropylamino-6-amino-s-triazine (CIAT) were detected in water from the Silver Springs group and in both boils at Gemini Springs. No pesticides were detected in water samples from De Leon Spring and Green Spring. Evidence of denitrification was indicated by the presence of excess nitrogen gas in water samples from most of the springs. Aquatic communities varied among the springs. Large floating mats of cyanobacteria (blue-green algae), identified as Lyngbya wollei, were observed in De Leon Spring during all sampling events in 2004. At Gemini Springs, the dominant periphyton was Rhizoclonium sp. Of the three springs sampled for benthic invertebrates, De Leon Spring had the highest overall species richness and most disturbance intolerant species (Florida Index = 4). Green Spring had the lowest species richness of the springs sampled. Based on qualitative comparisons, overall macroinvertebrate species richness seemed to be negatively related to magnesium, potassium, sodium, and specific conductance. Invertebrate abundance was greatest when dissolved oxygen and nitrate were high but phosphorus and potassium concentrations were low. Dipteran abundance seemed to be positively associated with specific conductance and total organic carbon but negatively associated with nitrate-N. Amphipods were the numerically dominant group collected in most (six of nine) collections. Shifts in amphipod abundance of the two species collected (Gammarus sp. and Hyalella azteca) varied by season among the three springs, but there were no trends evident in the variation. Fish populations were relatively species-rich at the Silver Springs group, De Leon Spring, and Gemini Springs, but not at Green Spring. Nonindigenous fish species were observed at all springs except Green Spring.

  6. Child mental health in Sierra Leone: a survey and exploratory qualitative study.

    PubMed

    Yoder, Hélène N C; Tol, Wietse A; Reis, Ria; de Jong, Joop T V M

    2016-01-01

    This study complements the growing amount of research on the psychosocial impact of war on children in Sierra Leone by examining local perceptions of child mental health, formal and informal care systems, help-seeking behaviour and stigma. The study combined: (1) a nationwide survey of mental health care providers, with (2) exploratory qualitative research among service users and providers and other stakeholders concerned with child and adolescent mental health, with a particular emphasis on local explanations and stigma. Formal mental health care services are extremely limited resulting in an estimated treatment gap of over 99.8 %. Local explanations of child mental health problems in Sierra Leone are commonly spiritual or supernatural in nature, and associated with help-seeking from traditional healers or religious institutions. There is a considerable amount of stigma related to mental disorders, which affects children, their caregivers and service providers, and may lead to discrimination and abuse. Child and Adolescent Mental Health (CAMH) care development in Sierra Leone should cater to the long-term structural effects of war-violence and an Ebola epidemic. Priorities for development include: (1) the strengthening of legal structures and the development of relevant policies that strengthen the health system and specifically include children and adolescents, (2) a clearer local distinction between children with psychiatric, neurological, developmental or psychosocial problems and subsequent channelling into appropriate services (3) supplementary CAMH training for a range of professionals working with children across various sectors, (4) specialist training in CAMH, (5) integration of CAMH care into primary health care, education and the social welfare system, (6) further research on local explanations of child mental disorders and the effect they have on the well-being of the child, and (7) a careful consideration of the role of religious healers as care providers.

  7. The Impact of the West Africa Ebola Outbreak on Obstetric Health Care in Sierra Leone.

    PubMed

    Brolin Ribacke, Kim J; van Duinen, Alex J; Nordenstedt, Helena; Höijer, Jonas; Molnes, Ragnhild; Froseth, Torunn Wigum; Koroma, A P; Darj, Elisabeth; Bolkan, Håkon Angel; Ekström, AnnaMia

    2016-01-01

    As Sierra Leone celebrates the end of the Ebola Virus Disease (EVD) outbreak, we can begin to fully grasp its impact on already weak health systems. The EVD outbreak in West Africa forced many hospitals to close down or reduce their activity, either to prevent nosocomial transmission or because of staff shortages. The aim of this study is to assess the potential impact of EVD on nationwide access to obstetric care in Sierra Leone. Community health officers collected weekly data between January 2014-May 2015 on in-hospital deliveries and caesarean sections (C-sections) from all open facilities (public, private for-profit and private non-profit sectors) offering emergency obstetrics in Sierra Leone. This was compared to official data of EVD cases per district. Logistic and Poisson regression analyses were used to compute risk and rate estimates. Nationwide, the number of in-hospital deliveries and C-sections decreased by over 20% during the EVD outbreak. The decline occurred early on in the EVD outbreak and was mainly attributable to the closing of private not-for-profit hospitals rather than government facilities. Due to difficulties in collecting data in the midst of an epidemic, limitations of this study include some missing data points. Both the number of in-hospital deliveries and C-sections substantially declined shortly after the onset of the EVD outbreak. Since access to emergency obstetric care, like C-sections, is associated with decreased maternal mortality, many women are likely to have died due to the reduced access to appropriate care during childbirth. Future research on indirect health effects of health system breakdown should ideally be nationwide and continue also into the recovery phase. It is also important to understand the mechanisms behind the deterioration so that important health services can be reestablished.

  8. Uranium series isotopes concentration in sediments at San Marcos and Luis L. Leon reservoirs, Chihuahua, Mexico

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Méndez-García, C.; Montero-Cabrera, M. E., E-mail: elena.montero@cimav.edu.mx; Renteria-Villalobos, M.

    2008-01-01

    Spatial and temporal distribution of the radioisotopes concentrations were determined in sediments near the surface and core samples extracted from two reservoirs located in an arid region close to Chihuahua City, Mexico. At San Marcos reservoir one core was studied, while from Luis L. Leon reservoir one core from the entrance and another one close to the wall were investigated. ²³²Th-series, ²³⁸U-series, ⁴⁰K and ¹³⁷Cs activity concentrations (AC, Bq kg⁻¹) were determined by gamma spectrometry with a high purity Ge detector. ²³⁸U and ²³⁴U ACs were obtained by liquid scintillation and alpha spectrometry with a surface barrier detector. Dating ofmore » core sediments was performed applying CRS method to ²¹⁰Pb activities. Results were verified by ¹³⁷Cs AC. Resulting activity concentrations were compared among corresponding surface and core sediments. High ²³⁸U-series AC values were found in sediments from San Marcos reservoir, because this site is located close to the Victorino uranium deposit. Low AC values found in Luis L. Leon reservoir suggest that the uranium present in the source of the Sacramento – Chuviscar Rivers is not transported up to the Conchos River. Activity ratios (AR) ²³⁴U/²³⁸U and ²³⁸U/²²⁶Ra in sediments have values between 0.9–1.2, showing a behavior close to radioactive equilibrium in the entire basin. ²³²Th/²³⁸U, ²²⁸Ra/²²⁶Ra ARs are witnesses of the different geological origin of sediments from San Marcos and Luis L. Leon reservoirs.« less

  9. Gross hematuria and urinary retention among men from a nationally representative survey in Sierra Leone.

    PubMed

    Patel, Hiten D; Kamara, Thaim B; Kushner, Adam L; Groen, Reinou S; Allaf, Mohamad E

    2014-06-01

    To estimate the prevalence of gross hematuria and urinary retention among men in Sierra Leone and report on barriers to care and associated disability. Gross hematuria and urinary retention are classic urologic complaints that require medical attention for significant underlying pathology, but their burden has not been quantified in a developing country. A cluster randomized, cross-sectional household survey was administered in Sierra Leone using the Surgeons OverSeas Assessment of Surgical need tool as a verbal head-to-toe examination. A total of 2 respondents in each of 25 households in 75 clusters were surveyed to assess surgical needs. Data on questions related to blood from the penis and the inability to urinate for men>12 years were included in the present analysis to determine the period and point prevalence of hematuria and urinary retention. From 3645 total respondents, 1054 (28.9%) were men>12 years included in the analysis. Period and point prevalence of gross hematuria were 21.8 per 1000 (95% confidence interval [CI] 13.0-30.7) and 12.3 per 1000 (95% CI 5.7-19.0), respectively, and for urinary retention, they were 19.9 per 1000 (95% CI 11.5-28.4) and 4.7 per 1000 (95% CI 0.5-8.9), respectively. Lack of financial resources was the major barrier to care. Disability assessment showed 19.1% were not able to work as a result of urinary retention, and 34.8% felt ashamed of their gross hematuria. The results provide a prevalence estimate of gross hematuria and urinary retention for men in Sierra Leone. Accessible medical and surgical care will be critical for early intervention and management. Copyright © 2014 Elsevier Inc. All rights reserved.

  10. Untreated head and neck surgical disease in Sierra Leone: a cross-sectional, countrywide survey.

    PubMed

    Van Buren, Nicholas C; Groen, Reinou S; Kushner, Adam L; Samai, Mohamed; Kamara, Thaim B; Ying, Jian; Meier, Jeremy D

    2014-10-01

    Demonstrate how the Surgeons OverSeas Assessment of Surgical Need (SOSAS) can be used to determine the burden of head and neck (H&N) surgical disease in developing countries and identify reasons for untreated disease. Cluster randomized, cross-sectional, countrywide survey. Sierra Leone. The survey was administered to 75 of 9671 enumeration areas in Sierra Leone between January 9 and February 3, 2012, with 25 households in each cluster randomly selected for the survey. A household representative and 2 randomly selected household members were interviewed. Need for surgical care was based on participants' responses to whether they had an H&N condition that they believed needed surgical care. Of 1875 households, data were analyzed for 1843 (98%), with 3645 total respondents. Seven hundred and one H&N surgical conditions were reported as occurring during the lifetime of the 3645 respondents (19.2%).The current prevalence of H&N conditions in need of a surgical consultation was 11.8%. No money (60.1%) was the most common reason respondents reported for not receiving medical care. A bivariate analysis demonstrated that age, village type, education, and type of condition may be predictors for seeking health care and/or receiving surgical care. These results show limited access for patients to be evaluated for a potential H&N surgical condition in Sierra Leone. The true incidence of untreated surgical disease is unknown as most respondents were not evaluated by a surgeon. This survey could be used in other countries as health care professionals assess surgical needs throughout the world. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2014.

  11. Safety of a condom uterine balloon tamponade (ESM-UBT) device for uncontrolled primary postpartum hemorrhage among facilities in Kenya and Sierra Leone.

    PubMed

    Ramanathan, Aparna; Eckardt, Melody J; Nelson, Brett D; Guha, Moytrayee; Oguttu, Monica; Altawil, Zaid; Burke, Thomas

    2018-05-15

    Postpartum hemorrhage is the leading cause of maternal mortality in low- and middle-income countries. While evidence on uterine balloon tamponade efficacy for severe hemorrhage is encouraging, little is known about safety of this intervention. The objective of this study was to evaluate the safety of an ultra-low-cost uterine balloon tamponade package (named ESM-UBT) for facility-based management of uncontrolled postpartum hemorrhage (PPH) in Kenya and Sierra Leone. Data were collected on complications/adverse events in all women who had an ESM-UBT device placed among 92 facilities in Sierra Leone and Kenya, between September 2012 and December 2015, as part of a multi-country study. Three expert maternal health investigator physicians analyzed each complication/adverse event and developed consensus on whether there was a potential causal relationship associated with use of the ESM-UBT device. Adverse events/complications specifically investigated included death, hysterectomy, uterine rupture, perineal or cervical injury, serious or minor infection, and latex allergy/anaphylaxis. Of the 201 women treated with an ESM-UBT device in Kenya and Sierra Leone, 189 (94.0%) survived. Six-week or longer follow-up was recorded in 156 of the 189 (82.5%). A causal relationship between use of an ESM-UBT device and one death, three perineal injuries and one case of mild endometritis could not be completely excluded. Three experts found a potential association between these injuries and an ESM-UBT device highly unlikely. The ESM-UBT device appears safe for use in women with uncontrolled PPH. Trial registration was not completed as data was collected as a quality assurance measure for the ESM-UBT kit.

  12. Factors for success in mental health advocacy

    PubMed Central

    Hann, Katrina; Pearson, Heather; Campbell, Doris; Sesay, Daniel; Eaton, Julian

    2015-01-01

    Background Mental health advocacy groups are an effective way of pushing the mental health agenda and putting pressure on national governments to observe the right to health; however, there is limited research that highlights best practices for such groups in low-resource settings. In an effort to improve the scaling up of mental health in Sierra Leone, stakeholders came together to form the country's first mental health advocacy group: the Mental Health Coalition – Sierra Leone. Since its inception, the group has worked towards raising the profile of mental health in Sierra Leone and developing as an advocacy organisation. Design The study's aim was to investigate views on enabling factors and barriers associated with mental health advocacy in a low-income country using a community-based participatory approach and qualitative methodology. Focus groups (N=9) were held with mental health stakeholders, and key informant interviews (N=15) were conducted with advocacy targets. Investigators analysed the data collaboratively using coding techniques informed by grounded theory. Results Investigators reveal viewpoints on key factors in networking, interacting with government actors, and awareness raising that enabled mental health advocacy aims of supporting policy, service delivery, service user rights, training for service delivery, and awareness raising. The investigators outline viewpoints on barriers for advocacy aims in framing the issue of mental health, networking, interacting with government actors, resource mobilization, and awareness raising. Conclusions The findings outline enabling factors, such as networking with key stakeholders, and barriers, such as lack of political will, for achieving mental health advocacy aims within a low-resource setting, Sierra Leone. Stakeholder coalitions can further key policy development aims that are essential to strengthen mental health systems in low-resource settings. PMID:26689456

  13. Factors for success in mental health advocacy.

    PubMed

    Hann, Katrina; Pearson, Heather; Campbell, Doris; Sesay, Daniel; Eaton, Julian

    2015-01-01

    Mental health advocacy groups are an effective way of pushing the mental health agenda and putting pressure on national governments to observe the right to health; however, there is limited research that highlights best practices for such groups in low-resource settings. In an effort to improve the scaling up of mental health in Sierra Leone, stakeholders came together to form the country's first mental health advocacy group: the Mental Health Coalition - Sierra Leone. Since its inception, the group has worked towards raising the profile of mental health in Sierra Leone and developing as an advocacy organisation. The study's aim was to investigate views on enabling factors and barriers associated with mental health advocacy in a low-income country using a community-based participatory approach and qualitative methodology. Focus groups (N=9) were held with mental health stakeholders, and key informant interviews (N=15) were conducted with advocacy targets. Investigators analysed the data collaboratively using coding techniques informed by grounded theory. Investigators reveal viewpoints on key factors in networking, interacting with government actors, and awareness raising that enabled mental health advocacy aims of supporting policy, service delivery, service user rights, training for service delivery, and awareness raising. The investigators outline viewpoints on barriers for advocacy aims in framing the issue of mental health, networking, interacting with government actors, resource mobilization, and awareness raising. The findings outline enabling factors, such as networking with key stakeholders, and barriers, such as lack of political will, for achieving mental health advocacy aims within a low-resource setting, Sierra Leone. Stakeholder coalitions can further key policy development aims that are essential to strengthen mental health systems in low-resource settings.

  14. Medical Officers in Sierra Leone: Surgical Training Opportunities, Challenges and Aspirations.

    PubMed

    Wilks, Lucy; Leather, Andrew; George, Peter Matthew; Kamara, Thaim Bay

    2018-02-05

    The critical shortage of human resources for healthcare falls most heavily on sub-Saharan nations such as Sierra Leone, where such workforce deficits have grave impacts on its burden of surgical disease. An important aspect in retention and development of the workforce is training. This study focuses on postgraduate surgical training (formal and short course) and perceptions of opportunities, challenges and aspirations, in a country where more than half of surgical procedures are performed by medical officers. The study presents findings from 12 in-depth semi-structured interviews conducted with medical officers by the primary investigator in Sierra Leone between April and June 2017. Each interview was transcribed alongside an introspective reflexive journal to acknowledge and account for researcher biases. Two interviewees had accessed postgraduate surgical training and 10 (83%) had accessed short course surgically relevant training. The number of short courses accessed grew higher the more recently the medical officers had graduated. Supervision, short length and international standards were the most appreciated aspects of short training courses. Some medical officers perceived the formal postgraduate surgical training programme to be ill-equipped, doubting its credibility. This demotivated some from applying. Training is an essential aspect of developing an adequate surgical workforce. Faith must be restored in the capabilities of Sierra Leone's Ministry of Health and Sanitation to provide adequate and sustainable training. This study advocates for the use of short courses to restore this faith and the expansion of postgraduate surgical training to the districts through developing a regional teaching complex to provide short courses and eventually formal postgraduate training in the future. Copyright © 2018 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

  15. [Leon Daraszkiewicz and his monograph on hebephrenia].

    PubMed

    Marcinowski, Filip

    2012-01-01

    Leon Daraszkiewicz (1866-1931) was a Polish psychiatrist, a pupil and co-worker of E. Kraepelin and V. Tsiz on the University of Dorpat (now Tartu, Estonia), the author of highly regarded monograph on hebephrenia (1891). In his work on the basis of over 20 case histories, he described a natural history of hebephrenia and his own views on its aetiology and prognosis. Hebephrenia as described by Daraszkiewicz, served as a clinical model for the Kraepelinian concept of dementia praecox. In the article, the life and career of Daraszkiewicz is covered, with particular emphasis on the role of his doctoral dissertation on hebephrenia in the history of the concept of schizophrenia.

  16. Habitat preferences of butterflies in the Bumbuna Forest, Northern Sierra Leone.

    PubMed

    Sundufu, Abu James; Dumbuya, Rashida

    2008-01-01

    The habitat preferences of the butterfly fauna were studied in the Bumbuna Forest Reserve in northern Sierra Leone. The intact forest reserve and a secondary forest regrowth, disturbed as a result of slash-and-burn agriculture, were compared to savanna habitats. Of the 290 specimens collected, 195 butterfly species were included, of which significant proportion were Nymphalidae. Of the 147 forest species, 111 (75.5%) showed preferences for the forest habitats, while 70 (47.6%) and 34 (23.1%) preferred disturbed and savannah habitats, respectively. Numerically, a comparable proportion of savannah species were recorded in the 18 disturbed (73.9%) and 16 savannah habitats (63.2%). Accumulated species richness and diversity indices were lower in the disturbed habitats compared to the forest reserve, but lowest in the savanna habitats. However, a large proportion of forest species, especially those with either a more restricted geographic range or species for which no information on geographic distribution was available, were exclusively captured in the forest patches. The survey indicated the presence of a rich butterfly fauna, which should be systematically collected for further research and study in order to build a good taxonomic database for Sierra Leone.

  17. Water quality associated public health risk in Bo, Sierra Leone.

    PubMed

    Jimmy, David H; Sundufu, Abu J; Malanoski, Anthony P; Jacobsen, Kathryn H; Ansumana, Rashid; Leski, Tomasz A; Bangura, Umaru; Bockarie, Alfred S; Tejan, Edries; Lin, Baochuan; Stenger, David A

    2013-01-01

    Human health depends on reliable access to safe drinking water, but in many developing countries only a limited number of wells and boreholes are available. Many of these water resources are contaminated with biological or chemical pollutants. The goal of this study was to examine water access and quality in urban Bo, Sierra Leone. A health census and community mapping project in one neighborhood in Bo identified the 36 water sources used by the community. A water sample was taken from each water source and tested for a variety of microbiological and physicochemical substances. Only 38.9% of the water sources met World Health Organization (WHO) microbial safety requirements based on fecal coliform levels. Physiochemical analysis indicated that the majority (91.7%) of the water sources met the requirements set by the WHO. In combination, 25% of these water resources met safe drinking water criteria. No variables associated with wells were statistically significant predictors of contamination. This study indicated that fecal contamination is the greatest health risk associated with drinking water. There is a need to raise hygiene awareness and implement inexpensive methods to reduce fecal contamination and improve drinking water safety in Bo, Sierra Leone.

  18. Treatment Seeking and Ebola Community Care Centers in Sierra Leone: A Qualitative Study.

    PubMed

    Carter, Simone E; O'Reilly, Marion; Frith-Powell, Jack; Umar Kargbo, Alpha; Byrne, Daniel; Niederberger, Eva

    2017-01-01

    Ebola Treatment Units were able to provide only 60% of necessary treatment beds in Sierra Leone. As a result, the Government of Sierra Leone decided to construct Community Care Centers. These were intended to increase treatment-seeking behavior and reduce the community-level spread of Ebola by facilitating access to care closer to communities. Through qualitative data collection in 3 districts, this study seeks to understand the perceived impact that proximity to such Centers had on treatment-seeking behavior. Feedback from community members and Community Health Volunteers indicates that proximity to treatment reduced fears, especially those arising from the use of ambulances, lack of familiarity with medical Centers, and loss of contact with family members taken for treatment. Participants report that having a Center close to their home enables them to walk to treatment and witness survivors being discharged. Living close to Centers also enables communities to be involved in their design and daily operation, helping to build trust in them as acceptable treatment facilities. Further research is required to understand the appropriate design, operation, and epidemiological impact of Centers. Further investigation should incorporate the effect of an outbreak's severity and the stage (duration) of the outbreak on potential acceptance of Centers.

  19. Identifying spatio-temporal dynamics of Ebola in Sierra Leone using virus genomes

    PubMed Central

    Proctor, Joshua L.

    2017-01-01

    Containing the recent West African outbreak of Ebola virus (EBOV) required the deployment of substantial global resources. Despite recent progress in analysing and modelling EBOV epidemiological data, a complete characterization of the spatio-temporal spread of Ebola cases remains a challenge. In this work, we offer a novel perspective on the EBOV epidemic in Sierra Leone that uses individual virus genome sequences to inform population-level, spatial models. Calibrated to phylogenetic linkages of virus genomes, these spatial models provide unique insight into the disease mobility of EBOV in Sierra Leone without the need for human mobility data. Consistent with other investigations, our results show that the spread of EBOV during the beginning and middle portions of the epidemic strongly depended on the size of and distance between populations. Our phylodynamic analysis also revealed a change in model preference towards a spatial model with power-law characteristics in the latter portion of the epidemic, correlated with the timing of major intervention campaigns. More generally, we believe this framework, pairing molecular diagnostics with a dynamic model selection procedure, has the potential to be a powerful forecasting tool along with offering operationally relevant guidance for surveillance and sampling strategies during an epidemic. PMID:29187639

  20. [Remarks on Leon Popielski's manuscript of his review of January Zubrzycki's qualifying thesis for professorship dating from 1915].

    PubMed

    Heimrath, T

    1994-01-01

    A review written by professor Leon Popielski from Lvov of the qualifying thesis for professorship of January Zubrzycki from Cracow is presented. The manuscript has been kept by professor Popielski's family. Zubrzycki finished his medical studies in Cracow in 1909. While writing his qualifying thesis entitled Placental Albumin Derivatives and their Toxic Properties in 1915 he was an assistant of Aleksander Rosner in the department of maternity and gynaecology of Jagiellonian University. In 1931 as a professor he became the head of the clinic and following the Second World War he was a professor at several faculties of medicine in Poland. He was an outstanding gynaecological surgeon, an author of a five volume atlas of gynaecological surgery. Professor Leon Popielski studied in S. Petersburg. He specialized in physiology. Since 1904 he was the head of the Chair of Pharmacologoy and Pharmacognosy at the Universitiy of Lvov. Popielski's intrest in Zubrzycki's work ensued his research on albumin metabolite effect. His appreciation of the work is expressed by the phrase "I read it with satisfaction". The review was written in 1919, belated by the war.

  1. Habitat Preferences of Butterflies in the Bumbuna Forest, Northern Sierra Leone

    PubMed Central

    Sundufu, Abu James; Dumbuya, Rashida

    2008-01-01

    The habitat preferences of the butterfly fauna were studied in the Bumbuna Forest Reserve in northern Sierra Leone. The intact forest reserve and a secondary forest regrowth, disturbed as a result of slash-and-burn agriculture, were compared to savanna habitats. Of the 290 specimens collected, 195 butterfly species were included, of which significant proportion were Nymphalidae. Of the 147 forest species, 111 (75.5%) showed preferences for the forest habitats, while 70 (47.6%) and 34 (23.1%) preferred disturbed and savannah habitats, respectively. Numerically, a comparable proportion of savannah species were recorded in the 18 disturbed (73.9%) and 16 savannah habitats (63.2%). Accumulated species richness and diversity indices were lower in the disturbed habitats compared to the forest reserve, but lowest in the savanna habitats. However, a large proportion of forest species, especially those with either a more restricted geographic range or species for which no information on geographic distribution was available, were exclusively captured in the forest patches. The survey indicated the presence of a rich butterfly fauna, which should be systematically collected for further research and study in order to build a good taxonomic database for Sierra Leone. PMID:20302525

  2. Getting the 'blues': the existence, diffusion and influence of pornography on young peoples' sexual health in Sierra Leone.

    PubMed

    Day, Andrea

    2014-01-01

    While substantial research has examined the effects of pornography on young people in developed societies, existing studies fall short in addressing how sexually-explicit material affects young people in developing countries. The importance of such knowledge increases as the globalising effects of technology expand young peoples' access and exposure to pornography. During the summer of 2012, a study was undertaken in Sierra Leone examining factors affecting young peoples' sexual and reproductive health. The research assessed the influence of HIV knowledge, communication about sex, civil war and contraception myths on sexual behaviours, while remaining open to unanticipated factors. During data collection, respondents identified pornography, also called blues, as an influential factor, detailing its newfound accessibility driven by improved access to information and communication technologies in the country. Respondents also addressed several presumed ways in which pornography impacts young peoples' decisions about sexual health. The following study examines perceived effects of young peoples' exposure to pornography based on existing literature. It then outlines the findings of research conducted in Sierra Leone, drawing on primary data from the respondents and relevant published literature and concludes with proposals for addressing its negative effects.

  3. Assessment of the potential for international dissemination of Ebola virus via commercial air travel during the 2014 west African outbreak

    PubMed Central

    Bogoch, Isaac I; Creatore, Maria I; Cetron, Martin S; Brownstein, John S; Pesik, Nicki; Miniota, Jennifer; Tam, Theresa; Hu, Wei; Nicolucci, Adriano; Ahmed, Saad; Yoon, James W; Berry, Isha; Hay, Simon I; Anema, Aranka; Tatem, Andrew J; MacFadden, Derek; German, Matthew; Khan, Kamran

    2015-01-01

    Summary Background The WHO declared the 2014 west African Ebola epidemic a public health emergency of international concern in view of its potential for further international spread. Decision makers worldwide are in need of empirical data to inform and implement emergency response measures. Our aim was to assess the potential for Ebola virus to spread across international borders via commercial air travel and assess the relative efficiency of exit versus entry screening of travellers at commercial airports. Methods We analysed International Air Transport Association data for worldwide flight schedules between Sept 1, 2014, and Dec 31, 2014, and historic traveller flight itinerary data from 2013 to describe expected global population movements via commercial air travel out of Guinea, Liberia, and Sierra Leone. Coupled with Ebola virus surveillance data, we modelled the expected number of internationally exported Ebola virus infections, the potential effect of air travel restrictions, and the efficiency of airport-based traveller screening at international ports of entry and exit. We deemed individuals initiating travel from any domestic or international airport within these three countries to have possible exposure to Ebola virus. We deemed all other travellers to have no significant risk of exposure to Ebola virus. Findings Based on epidemic conditions and international flight restrictions to and from Guinea, Liberia, and Sierra Leone as of Sept 1, 2014 (reductions in passenger seats by 51% for Liberia, 66% for Guinea, and 85% for Sierra Leone), our model projects 2·8 travellers infected with Ebola virus departing the above three countries via commercial flights, on average, every month. 91 547 (64%) of all air travellers departing Guinea, Liberia, and Sierra Leone had expected destinations in low-income and lower-middle-income countries. Screening international travellers departing three airports would enable health assessments of all travellers at highest risk of exposure to Ebola virus infection. Interpretation Decision makers must carefully balance the potential harms from travel restrictions imposed on countries that have Ebola virus activity against any potential reductions in risk from Ebola virus importations. Exit screening of travellers at airports in Guinea, Liberia, and Sierra Leone would be the most efficient frontier at which to assess the health status of travellers at risk of Ebola virus exposure, however, this intervention might require international support to implement effectively. Funding Canadian Institutes of Health Research. PMID:25458732

  4. Bacterial Activity and Geochemical Reactions in Submerged Cave Development -- Impact on Karst Aquifers in Florida

    NASA Astrophysics Data System (ADS)

    Herman, J. S.; Franklin, R. B.; Mills, A. L.; Giannotti, A. L.; Tysall, T. N.

    2008-05-01

    Elucidation of coupled mechanisms of sulfide oxidation and biomass generation supports an improved understanding the driving forces behind acid production, calcite dissolution, cave development, and karst aquifers characterization. Wekiwa Springs Cave and DeLeon Springs Cave, located in central Florida, both contain prolific bacterial mats from which sulfur-oxidizing bacteria have been identified. Wekiwa Springs Cave, a submerged cave developed in the Hawthorne Formation and located near Orlando, Florida, has groundwater discharge from the Floridian aquifer system, with some contribution from surficial and intermediate aquifers. The spring is the headwater of the Wekiwa River and releases a total of 170,000 m3 of water per day. The ceiling and walls are heavily covered (10 cm thick) with three morphologically distinct types of microbial mats largely comprising sulfur-oxidizing bacteria. Analysis of nearby groundwater collected from wells confirms sulfide concentrations in the regional groundwater of ~ 1.5 mg/L, though sulfide concentrations for water collected in the cave are below detection. Dissolved oxygen concentration in the water is low (<0.5 mg/L). DeLeon Springs Cave, a submerged cave located in Volusia County, Florida, is a single conduit with an average discharge of ~ 70,000 m3 of water per day, and water chemistry data suggest the presence of a saline seep in the system. Dense microbial mats cover the rock surfaces of the cave; the mats are highly filamentous, with long white streamers that often extend 1-2 feet from the cave wall. Microscopic analysis has confirmed the presence of sulfur granules within these bacterial cells, similar to those observed in the Wekiwa cave organisms. The water chemistry in DeLeon Springs Cave, however, is distinct from that of Wekiwa Springs Cave. Though DO, Fetotal, and HS- values are similar for the two sites, the concentration of ions such as Cl-, Na+, and SO42- are considerably higher at DeLeon. A similar contrast exists for the other major cations (Ca2+, Mg2+, K+), although the difference is less pronounced. An important difference between the two cave systems is the considerable spatial variability associated with water chemistry along the flowpath in the DeLeon system, whereas water chemistry is fairly constant at all locations sampled in Wekiwa Springs Cave. Microbial communities were characterized based on the on overall genetic similarity between whole-community DNA samples as compared using T-RFLP analysis of 16S rRNA genes. The microbial communities found at each sampling station in the Wekiwa Springs Cave are relatively similar to one another, while the communities found at the different sampling stations in the DeLeon Springs Cave are distinct from one another and from the Wekiwa community. This examination of submerged caves with respect to the specific speleogenic mechanisms and the importance of biological processes in their generation informs our understanding of caves and karst environments.

  5. [Molecular detection of hepatitis E virus in pig livers destined for human consumption in the state of Nuevo Leon, Mexico].

    PubMed

    Cantú-Martínez, Marco Antonio; Roig-Sagués, Artur Xavier; Cedillo-Rosales, Sibilina; Zamora-Ávila, Diana Elisa; Avalos-Ramírez, Ramiro

    2013-04-01

    Molecular detection of HEV in pig livers destined for human consumption in Nuevo Leon, Mexico. 87 livers were collected from pigs slaughtered in TIF and 40 livers from butchers. A 212 pb fragment of HEV ORF2 gene was amplified by semi-nested RT-PCR. 19.54% (17) of tif's and 22.5% (9) of butcher's livers were positive for HEV. Sequencing of the amplified products showed a 94%-95% homology with the sequences reported for genotype 3. Our results indicate that HEV is circulating in swine herds in the state, constituting a probable source of contamination of pig meat products.

  6. Effectiveness of spinosad and temephos for the control of mosquito larvae at a tire dump in Allende, Nuevo Leon, Mexico.

    PubMed

    Garza-Robledo, Argentina A; Martínez-Perales, Juan F; Rodríguez-Castro, Violeta A; Quiroz-Martínez, Humberto

    2011-12-01

    The effectiveness of spinosad and temephos for the control of mosquito larvae was evaluated in a tire dump in Allende, Nuevo Leon, Mexico. Three groups of 12 to 17 tires located in tree shade were utilized for this study. After the larvicides were applied, samples were collected weekly from 7 randomly chosen tires. The data showed a significant difference between the larvicides and control. Under the conditions of the present study, the effectiveness of spinosad against mosquito larvae was similar to that of temephos, both being effective for up to 91 days postapplication. In addition, spinosad allowed the establishment of the mosquito predator Toxorhynchites sp.

  7. A qualitative evaluation of the choice of traditional birth attendants for maternity care in 2008 Sierra Leone: implications for universal skilled attendance at delivery.

    PubMed

    Oyerinde, Koyejo; Harding, Yvonne; Amara, Philip; Garbrah-Aidoo, Nana; Kanu, Rugiatu; Oulare, Macoura; Shoo, Rumishael; Daoh, Kizito

    2013-07-01

    Maternal and newborn death is common in Sierra Leone; significant reductions in both maternal and newborn mortality require universal access to a skilled attendant during labor and delivery. When too few women use health facilities MDGs 4 and 5 targets will not be met. Our objectives were to identify why women use services provided by TBAs as compared to health facilities; and to suggest strategies to improve utilization of health facilities for maternity and newborn care services. Qualitative data from focus group discussions in communities adjacent to health facilities collected during the 2008 Emergency Obstetric and Newborn Care Needs Assessment were analyzed for themes relating to decision-making on the utilization of TBAs or health facilities. The prohibitive cost of services, and the geographic inaccessibility of health facilities discouraged women from using them while trust in the vast experience of TBAs as well as their compassionate care drew patients to them. Poor facility infrastructure, often absent staff, and the perception that facilities were poorly stocked and could not provide continuum of care services were barriers to facility utilization for maternity and newborn care. Improvements in infrastructure and the 24-hour provision of free, quality, comprehensive, and respectful care will minimize TBA preference in Sierra Leone.

  8. Food deserts in Leon County, FL: disparate distribution of Supplemental Nutrition Assistance Program-accepting stores by neighborhood characteristics.

    PubMed

    Rigby, Samantha; Leone, Angela F; Kim, Hwahwan; Betterley, Connie; Johnson, Mary Ann; Kurtz, Hilda; Lee, Jung Sun

    2012-01-01

    Examine whether neighborhood characteristics of racial composition, income, and rurality were related to distribution of Supplemental Nutrition Assistance Program (SNAP)-accepting stores in Leon County, Florida. Cross-sectional; neighborhood and food store data collected in 2008. Forty-eight census tracts as proxy of neighborhoods in Leon County, Florida. All stores and SNAP-accepting stores were identified from a commercial business directory and a United States Department of Agriculture SNAP-accepting store list, respectively (n = 288). Proportion of SNAP-accepting stores across neighborhoods. Descriptive statistics to describe distribution of SNAP-accepting stores by neighborhood characteristics. Proportions of SNAP-accepting stores were compared by neighborhood characteristics with Wilcoxon-Mann-Whitney and Kruskal-Wallis tests. Of 288 available stores, 45.1% accepted SNAP benefits. Of the 48 neighborhoods, 16.7% had no SNAP-accepting stores. Proportions of SNAP-accepting grocery stores were significantly different by neighborhood racial composition and income. Primarily black neighborhoods did not have any supermarkets. Results were mixed with regard to distribution of food stores and SNAP-accepting stores by neighborhood racial composition, income, and rurality. This study suggests disparities in distribution of SNAP-accepting stores across neighborhood characteristics of racial composition, income, and rurality. Copyright © 2012 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

  9. Transmission network of the 2014-2015 Ebola epidemic in Sierra Leone.

    PubMed

    Yang, Wan; Zhang, Wenyi; Kargbo, David; Yang, Ruifu; Chen, Yong; Chen, Zeliang; Kamara, Abdul; Kargbo, Brima; Kandula, Sasikiran; Karspeck, Alicia; Liu, Chao; Shaman, Jeffrey

    2015-11-06

    Understanding the growth and spatial expansion of (re)emerging infectious disease outbreaks, such as Ebola and avian influenza, is critical for the effective planning of control measures; however, such efforts are often compromised by data insufficiencies and observational errors. Here, we develop a spatial-temporal inference methodology using a modified network model in conjunction with the ensemble adjustment Kalman filter, a Bayesian inference method equipped to handle observational errors. The combined method is capable of revealing the spatial-temporal progression of infectious disease, while requiring only limited, readily compiled data. We use this method to reconstruct the transmission network of the 2014-2015 Ebola epidemic in Sierra Leone and identify source and sink regions. Our inference suggests that, in Sierra Leone, transmission within the network introduced Ebola to neighbouring districts and initiated self-sustaining local epidemics; two of the more populous and connected districts, Kenema and Port Loko, facilitated two independent transmission pathways. Epidemic intensity differed by district, was highly correlated with population size (r = 0.76, p = 0.0015) and a critical window of opportunity for containing local Ebola epidemics at the source (ca one month) existed. This novel methodology can be used to help identify and contain the spatial expansion of future (re)emerging infectious disease outbreaks. © 2015 The Author(s).

  10. Female Genital Mutilation in Sierra Leone: Forms, Reliability of Reported Status, and Accuracy of Related Demographic and Health Survey Questions

    PubMed Central

    Grant, Donald S.; Berggren, Vanja

    2013-01-01

    Objective. To determine forms of female genital mutilation (FGM), assess consistency between self-reported and observed FGM status, and assess the accuracy of Demographic and Health Surveys (DHS) FGM questions in Sierra Leone. Methods. This cross-sectional study, conducted between October 2010 and April 2012, enrolled 558 females aged 12–47 from eleven antenatal clinics in northeast Sierra Leone. Data on demography, FGM status, and self-reported anatomical descriptions were collected. Genital inspection confirmed the occurrence and extent of cutting. Results. All participants reported FGM status; 4 refused genital inspection. Using the WHO classification of FGM, 31.7% had type Ib; 64.1% type IIb; and 4.2% type IIc. There was a high level of agreement between reported and observed FGM prevalence (81.2% and 81.4%, resp.). There was no correlation between DHS FGM responses and anatomic extent of cutting, as 2.7% reported pricking; 87.1% flesh removal; and 1.1% that genitalia was sewn closed. Conclusion. Types I and II are the main forms of FGM, with labia majora alterations in almost 5% of cases. Self-reports on FGM status could serve as a proxy measurement for FGM prevalence but not for FGM type. The DHS FGM questions are inaccurate for determining cutting extent. PMID:24204384

  11. Study of the Wall Paintings of the Cenador Del Leon in the Real Alcazar of Seville

    NASA Astrophysics Data System (ADS)

    Robador, Maria Dolores; Mancera, Inmaculada; Perez-Maqueda, Rafael; Albardonedo, Antonio

    2017-10-01

    The paintings on the walls of the Cenador del Leon located in the gardens of the Real Alcazar in Seville next to the Pabellon de Carlos V in the Jardin Ingles area have been studied. The components of the wall paintings cross-sections, which were prepared using small samples taken from the walls of Cenador del Leon, were characterized using infrared spectroscopy (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM) with energy dispersive X-ray (EDX) analysis. The cross-sections of the collected samples indicated that the paint layer is well adhered to the preparation layer without any discontinuity, and only one carbonation layer exists at the top of the sequence of layers. These data suggest that the paint was applied on a fresco surface, and therefore, the adopted technique was fresco. Based on the different elements detected by EDX analysis of the cross-sections, the detected pigments included iron oxides accompanied by clay minerals (or earths) in the red pink, golden yellow and yellow colours, blue smelt for the blue colour and basic copper chloride (atacamite) for the green colour. In one sample, the particles were composed of Ba and S from barium sulphate and Ti and O from rutile titanium oxide due to a modern pigment.

  12. Traumatic injuries in developing countries: report from a nationwide cross-sectional survey of Sierra Leone.

    PubMed

    Stewart, Kerry-Ann A; Groen, Reinou S; Kamara, Thaim B; Farahzad, Mina M; Samai, Mohamed; Cassidy, Laura D; Kushner, Adam L; Wren, Sherry M

    2013-05-01

    To use a nationwide household survey tool to provide an estimate of injury prevalence, mechanisms of traumatic injuries, and number of injury-related deaths in a low-income country. A randomized, cross-sectional nationwide survey using the Surgeons OverSeas Assessment of Surgical Need tool was conducted in 2012. Sierra Leone, Africa. Three thousand seven hundred fifty randomly selected participants throughout Sierra Leone. Mechanisms of injury based on age, sex, anatomic location, cause, and sociodemographic factors as well as mechanisms of injury-related deaths in the previous year were the primary outcome measures. Data were collected and analyzed from 1843 households and 3645 respondents (98% response rate). Four hundred fifty-two respondents (12%) reported at least 1 traumatic injury in the preceding year. Falls were the most common cause of nonfatal injuries (40%). The extremities were the most common injury site regardless of age or sex. Traffic injuries were the leading cause of injury-related deaths (32% of fatal injuries). This study provides baseline data on the mechanisms of traumatic injuries as well as the sociodemographic factors affecting injury prevalence in one of the world's poorest nations. It is anticipated that these data will provide an impetus for further studies to determine injury severity, associated disability, and barriers to accessing care in these resource-poor areas.

  13. No Evidence for Lymphatic Filariasis Transmission in Big Cities Affected by Conflict Related Rural-Urban Migration in Sierra Leone and Liberia

    PubMed Central

    de Souza, Dziedzom K.; Sesay, Santigie; Moore, Marnijina G.; Ansumana, Rashid; Narh, Charles A.; Kollie, Karsor; Rebollo, Maria P.; Koudou, Benjamin G.; Koroma, Joseph B.; Bolay, Fatorma K.; Boakye, Daniel A.; Bockarie, Moses J.

    2014-01-01

    Background In West Africa, the principal vectors of lymphatic filariasis (LF) are Anopheles species with Culex species playing only a minor role in transmission, if any. Being a predominantly rural disease, the question remains whether conflict-related migration of rural populations into urban areas would be sufficient for active transmission of the parasite. Methodology/Principal Findings We examined LF transmission in urban areas in post-conflict Sierra Leone and Liberia that experienced significant rural-urban migration. Mosquitoes from Freetown and Monrovia, were analyzed for infection with Wuchereria bancrofti. We also undertook a transmission assessment survey (TAS) in Bo and Pujehun districts in Sierra Leone. The majority of the mosquitoes collected were Culex species, while Anopheles species were present in low numbers. The mosquitoes were analyzed in pools, with a maximum of 20 mosquitoes per pool. In both countries, a total of 1731 An. gambiae and 14342 Culex were analyzed for W. bancrofti, using the PCR. Two pools of Culex mosquitoes and 1 pool of An. gambiae were found infected from one community in Freetown. Pool screening analysis indicated a maximum likelihood of infection of 0.004 (95% CI of 0.00012–0.021) and 0.015 (95% CI of 0.0018–0.052) for the An. gambiae and Culex respectively. The results indicate that An. gambiae is present in low numbers, with a microfilaria prevalence breaking threshold value not sufficient to maintain transmission. The results of the TAS in Bo and Pujehun also indicated an antigen prevalence of 0.19% and 0.67% in children, respectively. This is well below the recommended 2% level for stopping MDA in Anopheles transmission areas, according to WHO guidelines. Conclusions We found no evidence for active transmission of LF in cities, where internally displaced persons from rural areas lived for many years during the more than 10 years conflict in Sierra Leone and Liberia. PMID:24516686

  14. Gastro Enteritis in a military population deployed in West Africa in the UK Ebola response; was the observed lower disease burden due to handwashing?

    PubMed

    Tuck, J J H; Williams, J R; Doyle, A L

    2016-01-01

    Travellers' diarrhoea in military populations is reported ranging from 50 to 70 cases per thousand person months. The UK personnel deployed to the Ebola Outbreak in Sierra Leone during the Ebola outbreak adopted standard measures associated with disease prevention. As part of the infection control measures against transmission of Ebola, personnel also rinsed their hands frequently in 0.05% hypochlorite. This was felt to have reduced the incidence of travellers' diarrhoea in the population and an audit was carried out to test this hypothesis. Routine data identified diarrhoea and vomiting cases. A questionnaire sought information on traveller's diarrhoea and hand hygiene in Sierra Leone and Afghanistan. The incidence of Gastro Intestinal Disease for the population ranged from 23.9 Per thousand personnel per month to 74.4 per thousand personnel per month (mean 55.1 cases per thousand personnel per month). This included 4 headline outbreaks which accounted for 156 of the total number of 243 cases in the period of the deployment. The mean daily number of hand washes in Sierra Leone as reported in a survey was 17.02 (SD 8.2) and for Afghanistan was 9.06 (6.88). The mean difference was 7.94 (t 0.64 p < 0.0001.) The gastro intestinal disease incidence appeared to be at the lower end of the range reported by other groups in an environment with, arguably, a greater risk of infection. Force health protection policies were similar between Sierra Leone and Afghanistan excepting the frequency with which hands were rinsed or washed. We recommend that hand washing stations are placed at every office and communal area and not just at the dining facility in order to minimise the incidence of travellers' diarrhoea on future operations. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Technical efficiency of peripheral health units in Pujehun district of Sierra Leone: a DEA application

    PubMed Central

    Renner, Ade; Kirigia, Joses M; Zere, Eyob A; Barry, Saidou P; Kirigia, Doris G; Kamara, Clifford; Muthuri, Lenity HK

    2005-01-01

    Background The Data Envelopment Analysis (DEA) method has been fruitfully used in many countries in Asia, Europe and North America to shed light on the efficiency of health facilities and programmes. There is, however, a dearth of such studies in countries in sub-Saharan Africa. Since hospitals and health centres are important instruments in the efforts to scale up pro-poor cost-effective interventions aimed at achieving the United Nations Millennium Development Goals, decision-makers need to ensure that these health facilities provide efficient services. The objective of this study was to measure the technical efficiency (TE) and scale efficiency (SE) of a sample of public peripheral health units (PHUs) in Sierra Leone. Methods This study applied the Data Envelopment Analysis approach to investigate the TE and SE among a sample of 37 PHUs in Sierra Leone. Results Twenty-two (59%) of the 37 health units analysed were found to be technically inefficient, with an average score of 63% (standard deviation = 18%). On the other hand, 24 (65%) health units were found to be scale inefficient, with an average scale efficiency score of 72% (standard deviation = 17%). Conclusion It is concluded that with the existing high levels of pure technical and scale inefficiency, scaling up of interventions to achieve both global and regional targets such as the MDG and Abuja health targets becomes far-fetched. In a country with per capita expenditure on health of about US$7, and with only 30% of its population having access to health services, it is demonstrated that efficiency savings can significantly augment the government's initiatives to cater for the unmet health care needs of the population. Therefore, we strongly recommend that Sierra Leone and all other countries in the Region should institutionalise health facility efficiency monitoring at the Ministry of Health headquarter (MoH/HQ) and at each health district headquarter. PMID:16354299

  16. Clinical illness and outcomes in patients with Ebola in Sierra Leone.

    PubMed

    Schieffelin, John S; Shaffer, Jeffrey G; Goba, Augustine; Gbakie, Michael; Gire, Stephen K; Colubri, Andres; Sealfon, Rachel S G; Kanneh, Lansana; Moigboi, Alex; Momoh, Mambu; Fullah, Mohammed; Moses, Lina M; Brown, Bethany L; Andersen, Kristian G; Winnicki, Sarah; Schaffner, Stephen F; Park, Daniel J; Yozwiak, Nathan L; Jiang, Pan-Pan; Kargbo, David; Jalloh, Simbirie; Fonnie, Mbalu; Sinnah, Vandi; French, Issa; Kovoma, Alice; Kamara, Fatima K; Tucker, Veronica; Konuwa, Edwin; Sellu, Josephine; Mustapha, Ibrahim; Foday, Momoh; Yillah, Mohamed; Kanneh, Franklyn; Saffa, Sidiki; Massally, James L B; Boisen, Matt L; Branco, Luis M; Vandi, Mohamed A; Grant, Donald S; Happi, Christian; Gevao, Sahr M; Fletcher, Thomas E; Fowler, Robert A; Bausch, Daniel G; Sabeti, Pardis C; Khan, S Humarr; Garry, Robert F

    2014-11-27

    Limited clinical and laboratory data are available on patients with Ebola virus disease (EVD). The Kenema Government Hospital in Sierra Leone, which had an existing infrastructure for research regarding viral hemorrhagic fever, has received and cared for patients with EVD since the beginning of the outbreak in Sierra Leone in May 2014. We reviewed available epidemiologic, clinical, and laboratory records of patients in whom EVD was diagnosed between May 25 and June 18, 2014. We used quantitative reverse-transcriptase-polymerase-chain-reaction assays to assess the load of Ebola virus (EBOV, Zaire species) in a subgroup of patients. Of 106 patients in whom EVD was diagnosed, 87 had a known outcome, and 44 had detailed clinical information available. The incubation period was estimated to be 6 to 12 days, and the case fatality rate was 74%. Common findings at presentation included fever (in 89% of the patients), headache (in 80%), weakness (in 66%), dizziness (in 60%), diarrhea (in 51%), abdominal pain (in 40%), and vomiting (in 34%). Clinical and laboratory factors at presentation that were associated with a fatal outcome included fever, weakness, dizziness, diarrhea, and elevated levels of blood urea nitrogen, aspartate aminotransferase, and creatinine. Exploratory analyses indicated that patients under the age of 21 years had a lower case fatality rate than those over the age of 45 years (57% vs. 94%, P=0.03), and patients presenting with fewer than 100,000 EBOV copies per milliliter had a lower case fatality rate than those with 10 million EBOV copies per milliliter or more (33% vs. 94%, P=0.003). Bleeding occurred in only 1 patient. The incubation period and case fatality rate among patients with EVD in Sierra Leone are similar to those observed elsewhere in the 2014 outbreak and in previous outbreaks. Although bleeding was an infrequent finding, diarrhea and other gastrointestinal manifestations were common. (Funded by the National Institutes of Health and others.).

  17. Building capacity for skilled birth attendance: An evaluation of the Maternal and Child Health Aides training programme in Sierra Leone.

    PubMed

    Jones, Susan; Ameh, Charles A; Gopalakrishnan, Somasundari; Sam, Betty; Bull, Florence; Labicane, Roderick R; Dabo, Fatmata; van den Broek, Nynke

    2015-12-01

    Maternal and Child Health Aides (MCH Aide) in Sierra Leone provide the majority of maternity services at primary care level. To formulate recommendations for improving the quality and scale-up of MCH Aides training an evaluation of all schools across Sierra Leone was undertaken. Structured, direct observation of two randomly selected teaching sessions per school using pre-tested standardised review forms. Event sampling with random selection of timetabled sessions across all 14 MCH Aide Training Schools. All MCH Aide training schools across Sierra Leone. Tutors across 14 MCH Aide training schools observed in August 2013. Assessment of four key elements of teaching and learning: (1) teaching style, (2) use of visual aids, (3) teaching environment and (4) student involvement. In the majority of teaching schools there was over-crowding (11/14), lack of furniture and inconsistent electricity supply. Ten of 26 tutors used lesson plans and teaching was mostly tutor- rather than student-focused. Majority of tutors use a didactic approach rather than active learning methods. Teaching aides were rarely available (15% of lessons). Tutors were knowledgeable in their subject area and there was evidence of an excellent tutor-student relationship. Training for Maternal and Child health Aides relies on teacher focused didactic methods, which may hinder student learning. Teaching and learning within the schools needs to be enhanced by a combination of tutor development and improvements in the learning environment. Interventions to improve the quality of teaching are urgently needed and should include training on teaching techniques and student assessment for tutors, provision of audio visual equipment and teaching aides such as posters and mannequins. Monitoring and Evaluation of interventions is critical to be able to amend the programmes approach and address further challenges at an early stage. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  18. Strengthening pre-service training for skilled birth attendance - An evaluation of the maternal and child health aide training programme in Sierra Leone.

    PubMed

    Jones, Susan A; Sam, Betty; Bull, Florence; James, Margaret; Ameh, Charles A; van den Broek, Nynke R

    2016-06-01

    The high maternal mortality rate in Sierra Leone combined with an ongoing shortage of midwives has led to the introduction of new cadres of healthcare workers. Maternal and Child Health Aides are one such cadre and now provide 56% of patient care. The quality of the education training programme for MCHA is therefore of paramount importance if high quality maternal care is to be provided. To conduct an evaluation of the MCHAide training programme in Sierra Leone. Mapping of programme and focus group discussions (FGDs) with key informants. Analysis of data using a thematic approach and formulation of recommendations for national, district and individual levels. All 14 MCHAide schools across Sierra Leone. The National Coordinator, Coordinators from 14 MCHAide schools and District Health Sisters from District Health Management Teams. Focus group discussions were held with tutors facilitated by a group member to encourage a free flowing discussion. Participants were divided into 4 groups, one for each province, with 5-8 participants per group and 50min for the discussion. Strengths, weaknesses and opportunities of the MCHAide training programme were identified. Four major themes were identified; the need for autonomy and support within the programme from stakeholders; the effect of poor infrastructure on teaching and student learning; the need to ensure rigorous academic quality including teaching quality, curricula content and the academic ability of the students; and the benefits of community support. It is important that the key personnel be involved in the development and introduction of training programmes for new cadres of staff from the earliest stages of development. On-going programme review and development is essential and those implementing the programme are the best placed to lead and contribute to this. Gathering the experiences and perceptions of key informants helps provide an in-depth examination that can inform recommendations. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  19. Traumatic Injuries in Developing Countries: Report from a Nationwide Cross-Sectional Survey of Sierra Leone

    PubMed Central

    Stewart, Kerry-Ann; Groen, Reinou S.; Kamara, Thaim B.; Farahzard, Mina; Samai, Mohamed; Yambasu, Sahr E.; Cassidy, Laura D.; Kushner, Adam L.; Wren, Sherry M.

    2014-01-01

    Objective Despite the tremendous disability and mortality caused by traumatic injuries worldwide, there is a relative dearth of information on the burden of injuries in developing countries. In an effort to document the surgical burden of disease in Sierra Leone, a nationwide survey was conducted utilizing the Surgeons OverSeas Assessment of Surgical Need (SOSAS) tool. Here, we report the injury data from this study with the aim to (1) provide an estimate of injury prevalence, (2) determine the mechanisms of injury, and (3) evaluate the degree of injury related deaths. Methods A population-based household survey was conducted in Sierra Leone in 2012. Participants were selected using a two-stage random sampling method, which generated a target population of 3750 participants across the 14 districts of Sierra Leone. Frequency distributions of mechanisms of injury based on age, sex, and urban versus rural residence were computed, and bivariate logistic regression models used to determine associations between sociodemographic factors and injury patterns. Results Data was analyzed from 1,843 households and 3,645 respondents, representing a response rate of 98.3%. Four hundred and fifty-two respondents (12.4%) reported at least one traumatic injury in the preceding year. Falls were the most common cause of non-fatal injuries, accounting for over 40% of injuries. The extremities were most commonly injured (55% of injuries) regardless of age or sex. Although motor vehicle related injuries were the 4th most common cause of injury overall, they were the leading cause of injury related deaths, accounting for almost 6% of fatal injuries. Conclusion This study provides baseline data on the burden of traumatic injuries in one of the world's poorest nations. In addition to injury prevention measures, immediate strategies to address current healthcare deficits are urgently needed in these resource poor areas. This report is an Original Article with Level I evidence. PMID:23325317

  20. Assessment of the potential for international dissemination of Ebola virus via commercial air travel during the 2014 west African outbreak.

    PubMed

    Bogoch, Isaac I; Creatore, Maria I; Cetron, Martin S; Brownstein, John S; Pesik, Nicki; Miniota, Jennifer; Tam, Theresa; Hu, Wei; Nicolucci, Adriano; Ahmed, Saad; Yoon, James W; Berry, Isha; Hay, Simon I; Anema, Aranka; Tatem, Andrew J; MacFadden, Derek; German, Matthew; Khan, Kamran

    2015-01-03

    The WHO declared the 2014 west African Ebola epidemic a public health emergency of international concern in view of its potential for further international spread. Decision makers worldwide are in need of empirical data to inform and implement emergency response measures. Our aim was to assess the potential for Ebola virus to spread across international borders via commercial air travel and assess the relative efficiency of exit versus entry screening of travellers at commercial airports. We analysed International Air Transport Association data for worldwide flight schedules between Sept 1, 2014, and Dec 31, 2014, and historic traveller flight itinerary data from 2013 to describe expected global population movements via commercial air travel out of Guinea, Liberia, and Sierra Leone. Coupled with Ebola virus surveillance data, we modelled the expected number of internationally exported Ebola virus infections, the potential effect of air travel restrictions, and the efficiency of airport-based traveller screening at international ports of entry and exit. We deemed individuals initiating travel from any domestic or international airport within these three countries to have possible exposure to Ebola virus. We deemed all other travellers to have no significant risk of exposure to Ebola virus. Based on epidemic conditions and international flight restrictions to and from Guinea, Liberia, and Sierra Leone as of Sept 1, 2014 (reductions in passenger seats by 51% for Liberia, 66% for Guinea, and 85% for Sierra Leone), our model projects 2.8 travellers infected with Ebola virus departing the above three countries via commercial flights, on average, every month. 91,547 (64%) of all air travellers departing Guinea, Liberia, and Sierra Leone had expected destinations in low-income and lower-middle-income countries. Screening international travellers departing three airports would enable health assessments of all travellers at highest risk of exposure to Ebola virus infection. Decision makers must carefully balance the potential harms from travel restrictions imposed on countries that have Ebola virus activity against any potential reductions in risk from Ebola virus importations. Exit screening of travellers at airports in Guinea, Liberia, and Sierra Leone would be the most efficient frontier at which to assess the health status of travellers at risk of Ebola virus exposure, however, this intervention might require international support to implement effectively. Canadian Institutes of Health Research. Copyright © 2015 Bogoch et al. Open Access article distributed under the terms of CC BY. Published by Elsevier Ltd. All rights reserved.

  1. GR712RC- Dual-Core Processor- Product Status

    NASA Astrophysics Data System (ADS)

    Sturesson, Fredrik; Habinc, Sandi; Gaisler, Jiri

    2012-08-01

    The GR712RC System-on-Chip (SoC) is a dual core LEON3FT system suitable for advanced high reliability space avionics. Fault tolerance features from Aeroflex Gaisler’s GRLIB IP library and an implementation using Ramon Chips RadSafe cell library enables superior radiation hardness.The GR712RC device has been designed to provide high processing power by including two LEON3FT 32- bit SPARC V8 processors, each with its own high- performance IEEE754 compliant floating-point-unit and SPARC reference memory management unit.This high processing power is combined with a large number of serial interfaces, ranging from high-speed links for data transfers to low-speed control buses for commanding and status acquisition.

  2. Population data of 24 STRs in Mexican-Mestizo population from Monterrey, Nuevo Leon (Northeast, Mexico) based on Powerplex(®) Fusion and GlobalFiler(®) kits.

    PubMed

    Ramos-González, Benito; Aguilar-Velázquez, José Alonso; Chávez-Briones, María de Lourdes; Delgado-Chavarría, Juan Ramón; Alfaro-Lopez, Elizabeth; Rangel-Villalobos, Héctor

    2016-03-01

    The STR loci included into new commercial human identification kits compels geneticists estimating forensic parameters for interpretation purposes in forensic casework. Therefore, we studied for the first time in Mexico the GlobalFiler(®) and Powerplex(®) Fusion systems in 326 and 682 unrelated individuals, respectively. These individuals are resident of the Monterrey City of the Nuevo Leon state (Northeast, Mexico). Population data from 23 autosomal STRs and the Y-STR locus DYS391 are reported and compared against available STR data from American ethnic groups and the unique Mexican population studied with Powerplex(®) Fusion. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  3. [The cultural psychiatry in Latin America].

    PubMed

    Villaseñor-Bayardo, Sergio J; Rojas-Malpica, Carlos; Aceves-Pulido, Martha P

    2014-01-01

    This paper presents only some of the most important contributions in the development of cultural psychiatry in Latin America. The continental efforts to understand the role that culture plays in the manifestation and treatment of mental disorders have been fruitful. The authors included are: Fernando Pagés of Argentina; Mario G. Hollweg of Bolivia; Rubim Alvaro de Pinho and Adalberto Barreto of Brazil; Carlos A. Leon and Carlos A. Uribe of Colombia; Antonio José A. Bustamante and Santa Cruz de Cuba, Carlos Leon Andrade of Ecuador, Guatemala Cristina Chavez; Sergio Villasenor J. Bayardo of Mexico; Carlos A. Seguin, Hermilio Valdizán and Javier Mariátegui in Peru; Y. Bespaldi of Consens of Uruguay; Rojas and Carlos Malpica and Jacqueline Briceño Clarac of Venezuela.

  4. Structural terranes and their relationships in Sierra Leone

    NASA Astrophysics Data System (ADS)

    Williams, Howard R.; Culver, Stephen J.

    Sierra Leone, composed mainly of Archaean granite-greenstone terrane, is bounded in the west by a westward dipping zone of intense, ductile, simple shear deformation which produced very fine-grained, high grade rocks. This zone has been interpreted as a possible Archaean suture developed following the collision of the Guyana Shield and the West African Craton. Granulite facies metamorphic supracrustals of the Kasila Group occur to the west of the sheared zone. Marampa Group lower grade metamorphics were thrust eastwards during the collision event. Late Precambrian rifting, well to the east of the mylonite zone and subsequent compression, preserved very low grade to unmetamorphosed Rokel River Group sediments and volcanics. Limited Pan-African tectonic transport of Archaean and late Precambrian material was again toward the east. All structural and stratigraphic units can be traced northward into Guinea where they disappear beneath the Paleozoic sediments of the Bové Basin. To the south, the Kasila Group, the granite-greenstone terrane and the mylonitized zone can be traced into Liberia. The Gibi Mountain Formation of Liberia is probably laterally equivalent to the lower portions of the Rokel River Group. This interpretation of the geology of Sierra Leone differs greatly from that of Guinea where the mylonitized zone, associated with a positive gravity anomaly, has been interpreted as a suture zone resulting from Pan-African continent-continent collision.

  5. Association between sickle cell and β-thalassemia genes and hemoglobin concentration and anemia in children and non-pregnant women in Sierra Leone: ancillary analysis of data from Sierra Leone's 2013 National Micronutrient Survey.

    PubMed

    Wirth, James P; Ansumana, Rashid; Woodruff, Bradley A; Koroma, Aminata S; Hodges, Mary H

    2018-01-17

    By measuring the associations between the presence of sickle cell and β-thalassemia genes, we assessed the extent to which these hemoglobinopathies contribute to the high prevalence of anemia observed in preschool-aged children and women of reproductive age in Sierra Leone. The prevalence of anemia was statistically significantly higher in children with homozygous sickle cell genes (HbSS) than in children with normal hemoglobin genes (HbAA or HbAC), but there was no difference in anemia prevalence in those with heterozygous sickle cell trait (HbAS or HbSC) compared with those with normal hemoglobin genes. In women, there was no difference in anemia prevalence by sickle cell status. In both children and women, there was no difference in the anemia prevalence for individuals with or without the β-thalassemia gene. For both sickle cell and β-thalassemia, there was no significant difference in hemoglobin concentrations by sickle cell or β-thalassemia status. Anemia prevalence was higher in children and women with homozygous sickle cell (HbSS). However, as the prevalence of HbSS children (5.4%) and women (1.6%) was quite small, it is unlikely that these hemoglobinopathies substantially contributed to the high anemia prevalence found in the 2013 national micronutrient survey.

  6. HIV/AIDS practice patterns, knowledge, and educational needs among Hispanic clinicians in Texas, USA, and Nuevo Leon, Mexico.

    PubMed

    Martinez, J L; Licea Serrato, J de D; Jimenez, R; Grimes, R M

    1998-07-01

    Hispanic clinicians in Texas, United States of America, and in the neighboring state of Nuevo Leon, Mexico, were surveyed to determine their educational needs in the area of HIV/AIDS. Two-thirds of the 74 Texan and 22% of the 104 Mexican physicians queried had seen at least one HIV/AIDS patient in the previous year. The majority of the respondents were primary care physicians who: 1) were in private practice; 2) saw more than 1,000 patients per year; 3) had been out of training for more than 10 years; 4) provided some HIV prevention education to patients based on their perceived risk of infection; 5) rated their own knowledge of HIV/AIDS as average but rated their knowledge of treatments for the disease below average; 6) received most of their information about HIV/AIDS from journals rather than formal continuing education programs; 7) thought Hispanic patients had special needs with regard to HIV/AIDS care; and 8) were willing to attend education programs to improve their HIV/AIDS management skills. The greatest barriers to caring for HIV patients were lack of clinical knowledge and fear of infection. These results point to a need for a large-scale training program to improve the HIV/AIDS management skills of Hispanic clinicians in Texas and Nuevo Leon.

  7. G6PD deficiency assessment in Freetown, Sierra Leone, reveals further insight into the molecular heterogeneity of G6PD A-.

    PubMed

    Jalloh, Amadu; Jalloh, Muctarr; Gamanga, Idrissa; Baion, David; Sahr, Foday; Gbakima, Aiah; Willoughby, Victor R; Matsuoka, Hiroyuki

    2008-01-01

    Glucose-6-phosphate dehydrogenase (G6PD) deficiency in Africa is of high prevalence, although precise data are lacking in many individual nations. We investigated 129 unrelated subjects (71 male subjects, 58 female subjects) visiting a teaching hospital in Freetown, Sierra Leone, to collect baseline data on the distribution of G6PD deficiency among respective ethnic groups in the country. We confirmed eight G6PD-deficient male subjects by two formazan-based blood tests (11.3% of the male subjects examined), and also detected the common 376A > G mutation in 11 male subjects and eight female subjects by sequencing exons 3-5 of the G6PD gene. Selected samples were further sequenced for exons 2-13 and introns 5, 7, 8, and 11. Among the deficient male subjects, six were G6PD A- carrying the double mutations (202G > A and 376A > G), all of whom were in the Temne and Mende ethnic groups. Others included A- Betica, and a novel variant having double mutations in exon 5 (311G > A and 376A > G forming 104 Arg > His and 126 Asn > Asp, respectively), which we designate as G6PD Sierra Leone. Subsequent haplotype analysis linked this novel variant to the G6PD A- "family".

  8. Influence of dental correction on nociceptive test responses, fecal appearance, body condition score, and apparent digestibility coefficient for dry matter of Zamorano-leones donkeys (Equus asinus).

    PubMed

    Rodrigues, J B; Ferreira, L M; Bastos, E; San Roman, F; Viegas, C; Santos, A S

    2013-10-01

    The influence of dental correction on nociceptive (pressure) test responses, fecal appearance, BCS, and apparent digestibility coefficient for DM was studied in 18 Zamorano-Leonés donkeys, an endangered local breed from the Zamora province in Spain. For this purpose, donkeys were divided into 2 homogeneous control and treatment groups, based on age, BCS, and dental findings. On d 1, 45, 90, and 135, BCS and nociceptive test responses were evaluated in all donkeys. Feed and fecal samples were collected from all donkeys for 3 consecutive days, starting at each of the aforementioned days. Apparent digestibility coefficient for DM was estimated, using ADL as an internal marker. A progressive decrease of positive nociceptive test responses was observed from d 1 up to 90 (P < 0.01) in the treatment group. No difference between groups was observed for BCS. However, BCS at d 90 was greater (P = 0.018) than observed on d 1 or 45, indicating a time influence. Concerning apparent digestibility coefficient for DM, there were differences among collection days in apparent digestibility coefficient for DM (P < 0.05). No differences in fecal appearance were observed between treatments or collection days. This study highlighted the importance of regular dental care for not only Zamorano-Leonés donkeys but also the equid population, in general, to improve their welfare.

  9. Training peers to treat Ebola centre workers with anxiety and depression in Sierra Leone.

    PubMed

    Waterman, Samantha; Hunter, Elaine Catherine Margaret; Cole, Charles L; Evans, Lauren Jayne; Greenberg, Neil; Rubin, G James; Beck, Alison

    2018-03-01

    Following the 2014 Ebola virus disease (EVD) outbreak in West Africa, the UK Department for International Development funded South London and Maudsley National Health Service (NHS) to develop a psychological intervention that ex-Ebola Treatment Centre (ETC) staff could be trained to deliver to their peers to improve mental health in Sierra Leone. The two key aims were to assess the feasibility of training a national team to deliver a cognitive behavioural therapy (CBT)-based group intervention, and to evaluate the effectiveness of the overall intervention within this population. UK clinicians travelled to Sierra Leone to train a small team of ex-ETC staff in a three-phased CBT-based intervention. Standardised clinical measures, as well as bespoke measures, were applied with participants through the intervention to assess changes in mental health symptomology, and the effectiveness of the intervention. The results found improvements across all factors of mental health in the bespoke measure from phase 1 to phase 3. Additionally, the majority of standardised clinical measures showed improvements between phase 2 and the start of phase 3, and pre- and post-phase 3. Overall, the findings suggest that it is possible to train staff from ETCs to deliver effective CBT interventions to peers. The implications of these results are discussed, including suggestions for future research and clinical intervention implementation within this population. The limitations of this research are also addressed.

  10. Iodine Status of Women of Reproductive Age in Sierra Leone and Its Association with Household Coverage with Adequately Iodized Salt

    PubMed Central

    Rohner, Fabian; Wirth, James P.; Woodruff, Bradley A.; Chiwile, Faraja; Yankson, Hannah; Sesay, Fatmata; Koroma, Aminata S.; Petry, Nicolai; Pyne-Bailey, Solade; Dominguez, Elisa; Kupka, Roland; Hodges, Mary H.; de Onis, Mercedes

    2016-01-01

    Salt iodization programs are a public health success in tackling iodine deficiency. Yet, a large proportion of the world’s population remains at risk for iodine deficiency. In a nationally representative cross-sectional survey in Sierra Leone, household salt samples and women’s urine samples were quantitatively analyzed for iodine content. Salt was collected from 1123 households, and urine samples from 817 non-pregnant and 154 pregnant women. Household coverage with adequately iodized salt (≥15 mg/kg iodine) was 80.7%. The median urinary iodine concentration (UIC) of pregnant women was 175.8 µg/L and of non-pregnant women 190.8 µg/L. Women living in households with adequately iodized salt had higher median UIC (for pregnant women: 180.6 µg/L vs. 100.8 µg/L, respectively, p < 0.05; and for non-pregnant women: 211.3 µg/L vs. 97.8 µg/L, p < 0.001). Differences in UIC by residence, region, household wealth, and women’s education were much smaller in women living in households with adequately iodized salt than in households without. Despite the high household coverage of iodized salt in Sierra Leone, it is important to reach the 20% of households not consuming adequately iodized salt. Salt iodization has the potential for increasing equity in iodine status even with the persistence of other risk factors for deficiency. PMID:26848685

  11. Occurrence and concentrations of selected trace elements and halogenated organic compounds in stream sediments and potential sources of polychlorinated biphenyls, Leon Creek, San Antonio, Texas, 2012–14

    USGS Publications Warehouse

    Wilson, Jennifer T.

    2016-06-23

    Sediment samples collected from Leon Creek by the USGS during 2007–9 and 2012–14 at a total of eight sites following identical field and laboratory methods were evaluated to determine if potential PCB sources could be identified. Total PCB concentrations in the sediment samples collected upstream from the Joint Base site were low or nondetections; while concentrations in the samples collected on and downstream from the Joint Base site were greater. Congeners 180 and 138 constituted the greatest proportion of the PCB mixture in samples collected upstream from, on, and downstream from the Joint Base site. Upstream from the Joint Base site, congeners 180 and 138 constituted 50 percent and 35 percent respectively of the PCBs congeners found in the samples. On and downstream from the Joint Base site, congeners 180 and 138 constituted 80 percent and 13 percent respectively of the PCBs congeners found in the samples. Chi-square (C2) tests also indicate that samples collected from the Loop 410 site were statistically different from samples collected from the Joint Base site and sites downstream. The PCB congener pattern in the Leon Creek samples is most like the congener mixture in Aroclor 1260, which is chemically similar to the PCBs detected in the fish samples that resulted in the 2003 fish consumption advisory.

  12. Bayesian inference in an extended SEIR model with nonparametric disease transmission rate: an application to the Ebola epidemic in Sierra Leone.

    PubMed

    Frasso, Gianluca; Lambert, Philippe

    2016-10-01

    SummaryThe 2014 Ebola outbreak in Sierra Leone is analyzed using a susceptible-exposed-infectious-removed (SEIR) epidemic compartmental model. The discrete time-stochastic model for the epidemic evolution is coupled to a set of ordinary differential equations describing the dynamics of the expected proportions of subjects in each epidemic state. The unknown parameters are estimated in a Bayesian framework by combining data on the number of new (laboratory confirmed) Ebola cases reported by the Ministry of Health and prior distributions for the transition rates elicited using information collected by the WHO during the follow-up of specific Ebola cases. The time-varying disease transmission rate is modeled in a flexible way using penalized B-splines. Our framework represents a valuable stochastic tool for the study of an epidemic dynamic even when only irregularly observed and possibly aggregated data are available. Simulations and the analysis of the 2014 Sierra Leone Ebola data highlight the merits of the proposed methodology. In particular, the flexible modeling of the disease transmission rate makes the estimation of the effective reproduction number robust to the misspecification of the initial epidemic states and to underreporting of the infectious cases. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  13. Assessing biodiversity in Nuevo Leon, Mexico: Are nature reserves the answer?

    USGS Publications Warehouse

    Cantu, C.; Wright, R.G.; Scott, J.M.; Strand, Espen

    2004-01-01

    The Mexican state of Nuevo Leon, located in the northeastern portion of the country, currently has 26 state and three federal nature reserves covering approximately 4.5% of its land area. These reserves were established for a variety of reasons not necessarily related to conservation purposes. In 2000 in response to a growing concern about the lack of organized conservation reserve planning to protect the important biological and physical features of Mexico, the Mexican Commission for Knowledge and Use of Biodiversity proposed 12 new terrestrial reserves for Nuevo Leon. The new reserves, if established, would increase the proportion of protected lands in the state to almost 24% of the state's land area. We compiled a Geographic Information System (GIS) analysis using digital thematic maps of physical and ecological features to examine how well the existing and proposed reserves incorporated the major biological and physical features of the state. The existing reserves are located primarily in regions with elevations > 1,000-1,500 m, on less productive soils, and are dominated by pine and oak forest cover types. As a result, the state's dominant biotic region - low elevation coastal plain with xeric scrub vegetation - is disproportionately under represented in the current reserve system. The new reserves would expand the protection of biophysical resources throughout the state. However, the inclusion of important resources in the low elevation coastal lands would still be limited.

  14. Monkeypox

    MedlinePlus

    ... Rohingya Democratic Republic of the Congo Ethiopia Iraq Nigeria Somalia South Sudan Syrian Arab Republic Yemen All ... Republic of the Congo, Cameroon, Central African Republic, Nigeria, Ivory Coast, Liberia, Sierra Leone, Gabon and South ...

  15. Onchocerciasis

    MedlinePlus

    ... Bangladesh Rohingya Democratic Republic of the Congo Iraq Nigeria Somalia South Sudan Syrian Arab Republic Yemen All ... Guinea-Bissau, Kenya, Liberia, Malawi, Mali, Mozambique, Niger, Nigeria, Rwanda, Senegal, Sierra Leone, South Sudan, Sudan, Togo, ...

  16. Combined 40Ar/39Ar and Fission-Track study of the Freetown Layered Igneous Complex, Freetown, Sierra Leone, West Africa: Implications for the Initial Break-up of Pangea to form the Central Atlantic Ocean and Insight into the Post-rift Evolution of the Sie

    NASA Astrophysics Data System (ADS)

    Barrie, Ibrahim; Wijbrans, Jan; Andriessen, Paul; Beunk, Frank; Strasser-King, Victor; Fode, Daniel

    2010-05-01

    Sierra Leone lies within the south-western part of the West African Craton and comprises two major Archaean structural divisions: a low-grade granite-greenstone terrane characterised by N-S striking structures and a NW-SE striking highly metamorphosed belt of strained rocks that form the coastal margin of the craton. Intruded into the belt is the Freetown Layered Igneous Complex (FLIC), a tholeiitic magamtic body emplaced prior to or during the break-up of Pangea to form the Central Atlantic Ocean and, forming today the high ground of the coastal outline of Sierra Leone which is one of the most distinctive features on the West African coast. The break-up of Pangaea to form the Central Atlantic and its passive margins began in the Early Jurassic. Geo-tectonically, the break-up was particularly characterised by the formation of the Central Atlantic Magmatic Province (CAMP), covering once-contiguous parts of North America, Europe, Africa and South America. The FLIC forming part of the heart of CAMP is the largest single layered igneous intrusive yet known on either side of the Central Atlantic, measuring on surface, 65 x 14 x 7 km. Geophysical investigations indicate that the intrusion extends offshore to a depth of about 20 km. Geologically the Complex is a rhythmically layered elongated ultramafic-mafic lopolith divisible into 4 major zones each comprising repeated sequences of troctolitic, gabbroic and anorthositic rocks. An idealised unit of layering is from base upwards: dunite, troctolite, olivine-gabbro, leuco-gabbro, gabbro-norite and anorthosite cumulates. 40Ar-39Ar age spectra and 40Ar/36Ar versus 39Ar/36Ar isochron plots obtained by stepwise-heating experiments on plagioclases, biotites and amphiboles from troctolites, olivine-gabbros, gabbro-norites and anorthosites of the four zones yield plateau and isochron ages that seem to depict the cooling history of the Complex after emplacement. The biotites and some of the plagioclases and amphiboles give very good plateaus that range from 196.3 ± 3 Ma to 232.1 ± 9 Ma with the best-fit isochron plots showing a range from 193.3± 10 Ma to 234.1 ± 11 Ma. Because these dates represent cooling ages, we interpret them as representing a minimum intrusion-age of the Complex implying that its true emplacement age might be somewhat older than 230 Ma. Given that most established CAMP ages revolve around 200 Ma or younger, we hypothesise that FLIC represents a hitherto unknown pre-CAMP magmatic event that might have thermally triggered the initial break-up of Pangaea to form the Central Atlantic. This view is consistent with field-observations that the Complex is cross-cut by predominantly coast-parallel mafic dykes attributed to the CAMP dyke-swarm. To ascertain the hypothesis, we are currently carrying out U-Pb zircon dating to establish, precisely, the true emplacement age of the Complex. The Fission-track ages vary from 91.7 ± 7 Ma to 114.6 ± 9 Ma. This age range shows that after emplacement and crystallisation, the FLIC underwent an extremely slow cooling for a long period of time. This in turn implies that after the break-up of Pangea to form, in part, the Sierra Leone margin, a late and slow uplift (Erosion/denudation) that took place during the Cretaceous was a very important geological process that characterised the post-rift evolution of the margin. References: Barrie, I.J., P.A.M. Andriessen, F.F. Beunk, J.R. Wijbrans, V.E.H. Strasser-King, D.V.A.Fode. (2006). Tectonothermal Evolution of the Sierra Leone Passive Continental Margin, West Africa: Constraints from Thermochronology. Geochemica et Cosmochemica Acta 70 (18): A36- A36 Suppl. S Aug-Sep 2006. Marzoli, A., P.R. Renne, E.M. Piccirillo, M. Ernesto, G. Bellieni, A De Min. (1999). Extensive 200-Million-Year-Old Continental Flood Basalts of the Central Atlantic Magmatic Province. Science284: 616-618. McHone, J.G. (2000). Non-plume magmatism and rifting during the opening of the central Atlantic Ocean. Tectonophysics, 316: 287-296. Umeji, A.C. (1983). Geochemistry and Mineralogy of the Freetown Layered Basic Igneous Complex of Sierra Leone. Chemical Geology, 39: 17-38. Wells, M.K. (1962). Structure and Petrology of the Freetown Layered Basic Complex of Sierra Leone. Overseas Geol. Mineral. Res. Bull. Suppl., 4, 115 pp. Williams, H.R. (1986). The Archaean Kaila Group of Western Sierra Leone: Geology and Relations with adjacent Granite-Greenstone Terrane. Precambrian Research, 38: 201-213.

  17. 7 CFR 1210.501 - Realignment of districts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., Gulf, Hamilton, Hernando, Holmes, Jackson, Jefferson, Lafayette, Leon, Levy, Liberty, Madison, Marion..., Virginia, Vermont, Wisconsin, West Virginia, and Washington, DC. (e) District 5—The State of California. (f...

  18. 7 CFR 1210.501 - Realignment of districts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., Gulf, Hamilton, Hernando, Holmes, Jackson, Jefferson, Lafayette, Leon, Levy, Liberty, Madison, Marion..., Virginia, Vermont, Wisconsin, West Virginia, and Washington, DC. (e) District 5—The State of California. (f...

  19. 7 CFR 1210.501 - Realignment of districts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., Gulf, Hamilton, Hernando, Holmes, Jackson, Jefferson, Lafayette, Leon, Levy, Liberty, Madison, Marion..., Virginia, Vermont, Wisconsin, West Virginia, and Washington, DC. (e) District 5—The State of California. (f...

  20. Map showing free-air gravity anomalies off the western coast of Africa Senegal (south of 15° north latitude) to Sierra Leone

    USGS Publications Warehouse

    Folger, D.W.; Irwin, B.J.; McCullough, J.R.; Driscoll, G.R.; Polloni, C.F.

    1990-01-01

    This map is one of six in a series presenting marine gravity data off the western coast of Africa (fig. 1).  The data, collected by the U.S. Geological Survey (USGS) in 1987 in response to a request from the Defense Mapping Agency, are intended to improve gravity coverage where it has been insufficient or inadequate.  The information shown on this and the other three maps that cover the African coast represents a total of approximately 32,000 line kilometers of marine gravity data from Western Sahara south to Gabon.  This map includes data collected off the coasts of Senegal, Gambia, Guinea-Bissau, Guinea, and Sierra Leone from July 22 to August 20, 1987.

  1. Community Care Centre (CCC) as adjunct in the management of Ebola Virus Disease (EVD) cases during outbreaks: experience from Sierra Leone

    PubMed Central

    Olu, Olushayo; Cormican, Martin; Kamara, Kande-Bure; Butt, Waqar

    2015-01-01

    Community Care Centres (CCCs) represent an innovative response to the containment of infection and the care of those infected in the context of an an Ebola Virus Disease (EVD) outbreak of unprecedented scale. This paper describes the implementation of this response in the Port Loko district of Sierra Leone in the last quarter of 2014. CCCs were effective in encouraging EVD patients to come forward, thus removing risk of transmission to their families and communities however there is significant scope for improvement in care for patients in the centres if the model is applied in future outbreaks of infectious disease. Changes in lay out of the centres, in staff training and support, in logistics and patient education are recommended. PMID:26740842

  2. [The panorama of coccidioidomycosis in Nuevo León from 1978 to 1988].

    PubMed

    González-Benavides, J

    1991-01-01

    The coccidioidomycosis is an endemic illness in the southern United States and the Northern of Mexico, the state of Texas and Nuevo Leon are included in this area. In the city of Monterrey from 1978 to 1988 the hospitals have reported one hundred and fifty cases. One hundred eleven of them from the state of Nuevo Leon and the remaining from the neighboring states. The main clinical presentation was in the pulmonary form with one hundred and twelve cases, followed by the cutaneous with thirty-three in the later the most common presentation was the ulcerated form. Therapeutically two new medication have been tried a with encouraging results, the itraconazole and the fluconazole the differential diagnosis is made mainly with tuberculosis and deep mycosis.

  3. Community Care Centre (CCC) as adjunct in the management of Ebola Virus Disease (EVD) cases during outbreaks: experience from Sierra Leone.

    PubMed

    Olu, Olushayo; Cormican, Martin; Kamara, Kande-Bure; Butt, Waqar

    2015-01-01

    Community Care Centres (CCCs) represent an innovative response to the containment of infection and the care of those infected in the context of an an Ebola Virus Disease (EVD) outbreak of unprecedented scale. This paper describes the implementation of this response in the Port Loko district of Sierra Leone in the last quarter of 2014. CCCs were effective in encouraging EVD patients to come forward, thus removing risk of transmission to their families and communities however there is significant scope for improvement in care for patients in the centres if the model is applied in future outbreaks of infectious disease. Changes in lay out of the centres, in staff training and support, in logistics and patient education are recommended.

  4. Sierra Leone's Former Child Soldiers: A Follow-up Study of Psychosocial Adjustment and Community Reintegration

    PubMed Central

    Betancourt, Theresa Stichick; Borisova, Ivelina Ivanova; Williams, Timothy Philip; Brennan, Robert T.; Whitfield, T. Hatch; de la Soudiere, Marie; Williamson, John; Gilman, Stephen E.

    2009-01-01

    This is the first prospective study to investigate psychosocial adjustment in male and female former child soldiers (n=156, 12% female). The study began in Sierra Leone in 2002 and was designed to examine both risk and protective factors in psychosocial adjustment. Over the two-year period of follow up, youth who had wounded or killed others during the war demonstrated increases in hostility. Youth who survived rape had higher levels of anxiety and hostility, but also demonstrated greater confidence and prosocial attitudes at follow up. Of the potential protective resources examined, improved community acceptance was associated with reduced depression at follow up and improved confidence and prosocial attitudes regardless of levels of violence exposure. Retention in school was also associated with greater prosocial attitudes. PMID:20636683

  5. Simulation of streamflow and water quality in the Leon Creek watershed, Bexar County, Texas, 1997-2004

    USGS Publications Warehouse

    Ockerman, Darwin J.; Roussel, Meghan C.

    2009-01-01

    The U.S. Geological Survey, in cooperation with the U.S. Army Corps of Engineers and the San Antonio River Authority, configured, calibrated, and tested a Hydrological Simulation Program ? FORTRAN watershed model for the approximately 238-square-mile Leon Creek watershed in Bexar County, Texas, and used the model to simulate streamflow and water quality (focusing on loads and yields of selected constituents). Streamflow in the model was calibrated and tested with available data from five U.S. Geological Survey streamflow-gaging stations for 1997-2004. Simulated streamflow volumes closely matched measured streamflow volumes at all streamflow-gaging stations. Total simulated streamflow volumes were within 10 percent of measured values. Streamflow volumes are greatly influenced by large storms. Two months that included major floods accounted for about 50 percent of all the streamflow measured at the most downstream gaging station during 1997-2004. Water-quality properties and constituents (water temperature, dissolved oxygen, suspended sediment, dissolved ammonia nitrogen, dissolved nitrate nitrogen, and dissolved and total lead and zinc) in the model were calibrated using available data from 13 sites in and near the Leon Creek watershed for varying periods of record during 1992-2005. Average simulated daily mean water temperature and dissolved oxygen at the most downstream gaging station during 1997-2000 were within 1 percent of average measured daily mean water temperature and dissolved oxygen. Simulated suspended-sediment load at the most downstream gaging station during 2001-04 (excluding July 2002 because of major storms) was 77,700 tons compared with 74,600 tons estimated from a streamflow-load regression relation (coefficient of determination = .869). Simulated concentrations of dissolved ammonia nitrogen and dissolved nitrate nitrogen closely matched measured concentrations after calibration. At the most downstream gaging station, average simulated monthly mean concentrations of dissolved ammonia and nitrate concentrations during 1997-2004 were 0.03 and 0.37 milligram per liter, respectively. For the most downstream station, the measured and simulated concentrations of dissolved and total lead and zinc for stormflows during 1993-97 after calibration do not match particularly closely. For base-flow conditions during 1997-2004 at the most downstream station, the simulated/measured match is better. For example, median simulated concentration of total lead (for 2,041 days) was 0.96 microgram per liter, and median measured concentration (for nine samples) of total lead was 1.0 microgram per liter. To demonstrate an application of the Leon Creek watershed model, streamflow constituent loads and yields for suspended sediment, dissolved nitrate nitrogen, and total lead were simulated at the mouth of Leon Creek (outlet of the watershed) for 1997-2004. The average suspended-sediment load was 51,800 tons per year. The average suspended-sediment yield was 0.34 ton per acre per year. The average load of dissolved nitrate at the outlet of the watershed was 802 tons per year. The corresponding yield was 10.5 pounds per acre per year. The average load of lead at the outlet was 3,900 pounds per year. The average lead yield was 0.026 pound per acre per year. The degree to which available rainfall data represent actual rainfall is potentially the most serious source of measurement error associated with the Leon Creek model. Major storms contribute most of the streamflow loads for certain constituents. For example, the three largest stormflows contributed about 64 percent of the entire suspended-sediment load at the most downstream station during 1997-2004.

  6. Find a Hematologist

    MedlinePlus

    ... Serbia Seychelles Sierra Leone Singapore Slovak Republic Slovenia Solomon Islands Somalia South Africa South Georgia Spain Sri ... Job Center ASH Apps Share Your Idea Donate Research Research Programs and Awards ASH Agenda for Hematology ...

  7. Find a Diabetes Educator

    MedlinePlus

    ... SENEGAL SERBIA SEYCHELLES SIERRA LEONE SINGAPORE SLOVAKIA SLOVENIA SOLOMON ISLANDS SOMALIA SOMALILAND SOUTH AFRICA SOUTH KOREA SOUTH ... Links Practice Patient Resources Education & Career News & Publications Research Join AADE Join Now Member Benefits Member Types ...

  8. Defense.gov Special Report: Travels with Panetta

    Science.gov Websites

    in Australia Defense Secretary Leon E. Panetta and Australian Defense Minister Stephen Smith have , Secretary Clinton, Minister Carr and Minister Smith at AUSMIN Ministerial, Perth, Australia Media

  9. 7 CFR 301.81-3 - Quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... entire county. Lee County. The entire county. Lenoir County. The entire county. Lincoln County. That... County. The entire county. Lee County. The entire county. Leon County. The entire county. Liberty County...

  10. 7 CFR 301.81-3 - Quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... entire county. Lee County. The entire county. Lenoir County. The entire county. Lincoln County. That... County. The entire county. Lee County. The entire county. Leon County. The entire county. Liberty County...

  11. Contraception determinants in youths of Sierra Leone are largely behavioral.

    PubMed

    Labat, Aline; Medina, Marta; Elhassein, Mohammed; Karim, Afrina; Jalloh, Mohammad B; Dramaix, Michèle; Zhang, Wei-Hong; Alexander, Sophie; Dickson, Kim E

    2018-04-19

    Sexual initiation occurs early in Sierra Leone. This study aims to analyze the determinants of condom and/or contraceptive use among a representative sample of young persons (10 to 24 years) in Sierra Leone. This is a secondary analysis of data from a study conducted to monitor the implementation of a UNFPA package of interventions directed to improve SRH in young people of Sierra Leone. This assessment was conducted in 2016 at the end of the Ebola outbreak. In consequence, determinants linked to healthy lifestyle behaviors and UNFPA interventions were explored in addition to the usual determinants: socio demographic and sexual lifestyle. This study is a household quantitative survey with open ended questions used to illustrate and complete the analysis. A total of 1409 young people were interviewed: of these, 216 boys and 381 girls were sexually active. Those who were pregnant or wished for pregnancy were excluded, leaving 194 boys and 268 girls for the analysis of determinants. The proportion of young people using neither condom nor other contraception at their last sexual intercourse in the whole sample was 40.5% and there was no statistically significant difference between boys and girls (42.3 vs 39.2; P = 0.504). Determinants were assessed and, after multivariable analysis, results differed between boys and girls and showed the importance of behavioral aspects. Four determinants were common to boys and girls: literacy, distance, negotiation capacity and hand washing. However, the distance factor for girls was to the health facility and for boys it was to school. Three more determinants remained in the boy's model: sleeping under a bednet, number of sexual partners and knowledge of contraceptive methods. Opinions about condoms and contraception revealed important barriers; opposition to contraceptive use was the main reason for non-use for both boys and girls, while lack of access was an important reason for boys. There is a need to reach out to the 40% of young people who are sexually active and neither pregnant nor with pregnancy desire, and are not using condom or contraception.

  12. SAFARI digital processing unit: performance analysis of the SpaceWire links in case of a LEON3-FT based CPU

    NASA Astrophysics Data System (ADS)

    Giusi, Giovanni; Liu, Scige J.; Di Giorgio, Anna M.; Galli, Emanuele; Pezzuto, Stefano; Farina, Maria; Spinoglio, Luigi

    2014-08-01

    SAFARI (SpicA FAR infrared Instrument) is a far-infrared imaging Fourier Transform Spectrometer for the SPICA mission. The Digital Processing Unit (DPU) of the instrument implements the functions of controlling the overall instrument and implementing the science data compression and packing. The DPU design is based on the use of a LEON family processor. In SAFARI, all instrument components are connected to the central DPU via SpaceWire links. On these links science data, housekeeping and commands flows are in some cases multiplexed, therefore the interface control shall be able to cope with variable throughput needs. The effective data transfer workload can be an issue for the overall system performances and becomes a critical parameter for the on-board software design, both at application layer level and at lower, and more HW related, levels. To analyze the system behavior in presence of the expected SAFARI demanding science data flow, we carried out a series of performance tests using the standard GR-CPCI-UT699 LEON3-FT Development Board, provided by Aeroflex/Gaisler, connected to the emulator of the SAFARI science data links, in a point-to-point topology. Two different communication protocols have been used in the tests, the ECSS-E-ST-50-52C RMAP protocol and an internally defined one, the SAFARI internal data handling protocol. An incremental approach has been adopted to measure the system performances at different levels of the communication protocol complexity. In all cases the performance has been evaluated by measuring the CPU workload and the bus latencies. The tests have been executed initially in a custom low level execution environment and finally using the Real- Time Executive for Multiprocessor Systems (RTEMS), which has been selected as the operating system to be used onboard SAFARI. The preliminary results of the carried out performance analysis confirmed the possibility of using a LEON3 CPU processor in the SAFARI DPU, but pointed out, in agreement with previous similar studies, the need of carefully designing the overall architecture to implement some of the DPU functionalities on additional processing devices.

  13. Peer-driven quality improvement among health workers and traditional birth attendants in Sierra Leone: linkages between providers' organizational skills and relationships.

    PubMed

    Higgins-Steele, Ariel; Waller, Kathryn; Fotso, Jean Christophe; Vesel, Linda

    2015-01-01

    Sierra Leone has among the poorest maternal and child health indicators in the world and investments in public health have been predominately to increase demand for services, with fewer initiatives targeting supply side factors that influence health workers' work environment. This paper uses data from the Quality Circles project in a rural district of Sierra Leone to achieve three objectives. First, we examine the effect of the intervention on organizational skills and relationships among coworkers as well as between health workers and traditional birth attendants. Second, we examine whether changes in organizational skills are associated with changes in relationships among and between formal and informal health providers and between health providers and clients. Third, we aim to further understand these changes through the perspectives of health workers and traditional birth attendants. The Quality Circles project was implemented in Kailahun District in the Eastern province of Sierra Leone from August 2011 to June 2013, with adjacent Tonkolili District serving as the control site. Using a mixed-methods approach, the evaluation included a quantitative survey, in-depth interviews and focus group discussions with health workers and traditional birth attendants. Mean values of the variables of interest were compared across sub-populations, and correlation analyses were performed between changes in organizational skills and changes in relationships. The results demonstrate that the Quality Circles intervention had positive effects on organizational skills and relationships. Furthermore, improvements in all organizational skill variables - problem-solving, strategizing and negotiation skills - were strongly associated with a change in the overall relationship variable. The Quality Circles approach has the potential to support health workers to improve their organizational skills and relationships, which in turn can contribute to improving the interpersonal dimensions of the quality of care in low-resource contexts. This method brings together peers in a structured process for constructive group work and individual skill development, which are important in low-resource contexts where active participation and resourcefulness of health workers can also contribute to better health service delivery.

  14. Potential Exposure to Ebola Virus from Body Fluids due to Ambulance Compartment Permeability in Sierra Leone.

    PubMed

    Casey, Megan L; Nguyen, Duong T; Idriss, Barrie; Bennett, Sarah; Dunn, Angela; Martin, Stephen

    2015-12-01

    Prehospital care, including patient transport, is integral in the patient care process during the Ebola response. Transporting ill persons from the community to Ebola care facilities can stop community spread. Vehicles used for patient transport in infectious disease outbreaks should be evaluated for adequate infection prevention and control. An ambulance driver in Sierra Leone attributed his Ebola infection to exposure to body fluids that leaked from the patient compartment to the driver cabin of the ambulance. A convenience sample of 14 vehicles used to transport patients with suspected or confirmed Ebola in Sierra Leone were assessed. The walls separating the patient compartment and driver cabin in these vehicles were evaluated for structural integrity and potential pathways for body fluid leakage. Ambulance drivers and other staff were asked to describe their cleaning and decontamination practices. Ambulance construction and design standards from the National Fire Protection Association, US General Services Administration, and European Committee on Standardization (CEN) were reviewed. Many vehicles used by ambulance staff in Sierra Leone were not traditional ambulances, but were pick-up trucks or sport-utility vehicles that had been assembled or modified for patient transport. The wall separating the patient compartment and driver cabin in many vehicles did not have a waterproof seal around the edges. Staff responsible for cleaning and disinfection did not thoroughly clean bulk body fluids with disposable towels before disinfection of the patient compartment. Pressure from chlorine sprayers used in the decontamination process may have pushed body fluids from the patient compartment into the driver cabin through gaps around the wall. Ambulance design standards do not require a waterproof seal between the patient compartment and driver cabin. Sealing the wall by tightening or replacing existing bolts is recommended, followed by caulking of all seams with a sealant. Waterproof separation between the patient compartment and driver cabin may be essential for patient transport vehicles in infectious disease outbreaks, especially when chlorine sprayers are used for decontamination or in resource-limited settings where cleaning supplies may be limited.

  15. Psychosocial support and resilience building among health workers in Sierra Leone: interrelations between coping skills, stress levels, and interpersonal relationships.

    PubMed

    Vesel, Linda; Waller, Kathryn; Dowden, Justine; Fotso, Jean Christophe

    2015-01-01

    In low- and middle-income countries, a shortage of properly trained, supervised, motivated and equitably distributed health workers often hinder the delivery of lifesaving interventions. Various health workforce bottlenecks can be addressed by tackling well-being and interpersonal relationships of health workers with their colleagues and clients. This paper uses data from the Helping Health Workers Cope (HHWC) project in a rural district of Sierra Leone to achieve three objectives. First, we describe the effect of counseling and psychosocial training on coping skills, stress levels, and provider-provider and provider-client relationships. Second, we examine whether a change in coping skills is associated with a change in relationships. Finally, we qualitatively identify key ways through which the uptake of coping skills is linked to a change in relationships. The HHWC project was implemented from February 2012 to June 2013 in Kono district in the Eastern province of Sierra Leone, with the neighboring district of Tonkolili selected as the control site. The evaluation followed a mixed-methods approach, which included a quantitative survey, in-depth interviews and focus group discussions with health workers and clients. Mean values of the variables of interest were compared across sub-populations, and correlation analyses were performed between changes in coping skills, stress levels, and changes in relationships. Overall, the results demonstrate that the HHWC intervention had a positive effect on coping skills, stress levels and provider-provider and provider-client relationships. Furthermore, associations were observed between changes in coping skills and changes in relationships as well as changes in stress management skills and changes in relationships. Psychosocial education can have major impacts on health worker well-being and the quality of health care delivery. Integrating psychosocial counseling and training interventions into health worker pre-service and in-service curricula would allow the positive effects of the HHWC intervention to be scaled up across Sierra Leone and beyond. A roll out of the HHWC approach alongside health system strengthening initiatives could have major implications for improving health and chances of survival.

  16. Estimating the future number of cases in the Ebola epidemic--Liberia and Sierra Leone, 2014-2015.

    PubMed

    Meltzer, Martin I; Atkins, Charisma Y; Santibanez, Scott; Knust, Barbara; Petersen, Brett W; Ervin, Elizabeth D; Nichol, Stuart T; Damon, Inger K; Washington, Michael L

    2014-09-26

    The first cases of the current West African epidemic of Ebola virus disease (hereafter referred to as Ebola) were reported on March 22, 2014, with a report of 49 cases in Guinea. By August 31, 2014, a total of 3,685 probable, confirmed, and suspected cases in West Africa had been reported. To aid in planning for additional disease-control efforts, CDC constructed a modeling tool called EbolaResponse to provide estimates of the potential number of future cases. If trends continue without scale-up of effective interventions, by September 30, 2014, Sierra Leone and Liberia will have a total of approximately 8,000 Ebola cases. A potential underreporting correction factor of 2.5 also was calculated. Using this correction factor, the model estimates that approximately 21,000 total cases will have occurred in Liberia and Sierra Leone by September 30, 2014. Reported cases in Liberia are doubling every 15-20 days, and those in Sierra Leone are doubling every 30-40 days. The EbolaResponse modeling tool also was used to estimate how control and prevention interventions can slow and eventually stop the epidemic. In a hypothetical scenario, the epidemic begins to decrease and eventually end if approximately 70% of persons with Ebola are in medical care facilities or Ebola treatment units (ETUs) or, when these settings are at capacity, in a non-ETU setting such that there is a reduced risk for disease transmission (including safe burial when needed). In another hypothetical scenario, every 30-day delay in increasing the percentage of patients in ETUs to 70% was associated with an approximate tripling in the number of daily cases that occur at the peak of the epidemic (however, the epidemic still eventually ends). Officials have developed a plan to rapidly increase ETU capacities and also are developing innovative methods that can be quickly scaled up to isolate patients in non-ETU settings in a way that can help disrupt Ebola transmission in communities. The U.S. government and international organizations recently announced commitments to support these measures. As these measures are rapidly implemented and sustained, the higher projections presented in this report become very unlikely.

  17. Geographical distribution of intestinal schistosomiasis and soil-transmitted helminthiasis and preventive chemotherapy strategies in Sierra Leone.

    PubMed

    Koroma, Joseph B; Peterson, Jen; Gbakima, Aiah A; Nylander, Francis E; Sahr, Foday; Soares Magalhães, Ricardo J; Zhang, Yaobi; Hodges, Mary H

    2010-11-23

    A national baseline mapping of schistosomiasis and soil-transmitted helminthiasis (STH) was performed in Sierra Leone. The aim was to provide necessary tools for the Ministry of Health and Sanitation to plan the intervention strategies in the national integrated control program on neglected tropical diseases according to the World Health Organization (WHO) guidelines for preventative chemotherapy (PCT) and for future monitoring and evaluation. 53 primary schools were randomly selected through a two-staged random sampling throughout the country. Approximately one hundred children aged 5-16 years of age were systematically selected from each school and their stool samples examined in a field laboratory. A total of 5,651 samples were examined. Data were analyzed with multivariable logistic regression models using model-based geostatistics. Spatial analysis predicted that S. mansoni infection was positively associated with population density and elevation and that there was a large cluster of high risk of S. mansoni infection (prevalence >70%) in the north and most of the eastern areas of the country, in line with the observed prevalence in Kono (63.8-78.3%), Koinadugu (21.6-82.1%), Kailahun (43.5-52.6%), Kenema (6.1-68.9%) and Tonkolili (0-57.3%). Hookworm infection was negatively associated with population density and land surface temperature, and was high across Sierra Leone with a large cluster of high infection risk (prevalence >70%) in the north-eastern part of the country. Remarkably low prevalence of Ascaris lumbricoides (7.2%) and Trichuris trichiura (3.3%) was recorded when compared with results published in the 1990s. Results justify PCT for schistosomiasis for school age children and at-risk adults every year in high-risk communities in five districts and every two years in moderate-risk communities in one more district. The high prevalence of STH, particularly hookworm, coupled with widespread anemia according to a national report in Sierra Leone, suggests all but one district justifying biannual PCT for STH for pre-school children, school age children, and at-risk adults. PCT for STH in the remaining district, Kono is justified annually.

  18. Contact Tracing during an Outbreak of Ebola Virus Disease in the Western Area Districts of Sierra Leone: Lessons for Future Ebola Outbreak Response.

    PubMed

    Olu, Olushayo Oluseun; Lamunu, Margaret; Nanyunja, Miriam; Dafae, Foday; Samba, Thomas; Sempiira, Noah; Kuti-George, Fredson; Abebe, Fikru Zeleke; Sensasi, Benjamin; Chimbaru, Alexander; Ganda, Louisa; Gausi, Khoti; Gilroy, Sonia; Mugume, James

    2016-01-01

    Contact tracing is a critical strategy required for timely prevention and control of Ebola virus disease (EVD) outbreaks. Available evidence suggests that poor contact tracing was a driver of the EVD outbreak in West Africa, including Sierra Leone. In this article, we answered the question as to whether EVD contact tracing, as practiced in Western Area (WA) districts of Sierra Leone from 2014 to 2015, was effective. The goal is to describe contact tracing and identify obstacles to its effective implementation. Mixed methods comprising secondary data analysis of the EVD case and contact tracing data sets collected from WA during the period from 2014 to 2015, key informant interviews of contact tracers and their supervisors, and a review of available reports on contact tracing were implemented to obtain data for this study. During the study period, 3,838 confirmed cases and 32,706 contacts were listed in the viral hemorrhagic fever and contact databases for the district (mean 8.5 contacts per case). Only 22.1% (852) of the confirmed cases in the study area were listed as contacts at the onset of their illness, which indicates incomplete identification and tracing of contacts. Challenges associated with effective contact tracing included lack of community trust, concealing of exposure information, political interference with recruitment of tracers, inadequate training of contact tracers, and incomplete EVD case and contact database. While the tracers noted the usefulness of community quarantine in facilitating their work, they also reported delayed or irregular supply of basic needs, such as food and water, which created resistance from the communities. Multiple gaps in contact tracing attributed to a variety of factors associated with implementers, and communities were identified as obstacles that impeded timely control of the EVD outbreak in the WA of Sierra Leone. In future outbreaks, early community engagement and participation in contact tracing, establishment of appropriate mechanisms for selection, adequate training and supervision of qualified contact tracers, establishment of a well-managed and complete contact tracing database, and provision of basic needs to quarantined contacts are recommended as measures to enhance effective contact tracing.

  19. Geographical Distribution of Intestinal Schistosomiasis and Soil-Transmitted Helminthiasis and Preventive Chemotherapy Strategies in Sierra Leone

    PubMed Central

    Koroma, Joseph B.; Peterson, Jen; Gbakima, Aiah A.; Nylander, Francis E.; Sahr, Foday; Soares Magalhães, Ricardo J.; Zhang, Yaobi; Hodges, Mary H.

    2010-01-01

    Background A national baseline mapping of schistosomiasis and soil-transmitted helminthiasis (STH) was performed in Sierra Leone. The aim was to provide necessary tools for the Ministry of Health and Sanitation to plan the intervention strategies in the national integrated control program on neglected tropical diseases according to the World Health Organization (WHO) guidelines for preventative chemotherapy (PCT) and for future monitoring and evaluation. Methodology/Principal Findings 53 primary schools were randomly selected through a two-staged random sampling throughout the country. Approximately one hundred children aged 5–16 years of age were systematically selected from each school and their stool samples examined in a field laboratory. A total of 5,651 samples were examined. Data were analyzed with multivariable logistic regression models using model-based geostatistics. Spatial analysis predicted that S. mansoni infection was positively associated with population density and elevation and that there was a large cluster of high risk of S. mansoni infection (prevalence >70%) in the north and most of the eastern areas of the country, in line with the observed prevalence in Kono (63.8–78.3%), Koinadugu (21.6–82.1%), Kailahun (43.5–52.6%), Kenema (6.1–68.9%) and Tonkolili (0–57.3%). Hookworm infection was negatively associated with population density and land surface temperature, and was high across Sierra Leone with a large cluster of high infection risk (prevalence >70%) in the north-eastern part of the country. Remarkably low prevalence of Ascaris lumbricoides (7.2%) and Trichuris trichiura (3.3%) was recorded when compared with results published in the 1990s. Conclusions/Significance Results justify PCT for schistosomiasis for school age children and at-risk adults every year in high-risk communities in five districts and every two years in moderate-risk communities in one more district. The high prevalence of STH, particularly hookworm, coupled with widespread anemia according to a national report in Sierra Leone, suggests all but one district justifying biannual PCT for STH for pre-school children, school age children, and at-risk adults. PCT for STH in the remaining district, Kono is justified annually. PMID:21124881

  20. Low referral completion of rapid diagnostic test-negative patients in community-based treatment of malaria in Sierra Leone

    PubMed Central

    2011-01-01

    Background Malaria is hyper-endemic and a major public health problem in Sierra Leone. To provide malaria treatment closer to the community, Médecins Sans Frontières (MSF) launched a community-based project where Community Malaria Volunteers (CMVs) tested and treated febrile children and pregnant women for malaria using rapid diagnostic tests (RDTs). RDT-negative patients and severely ill patients were referred to health facilities. This study sought to determine the referral rate and compliance of patients referred by the CMVs. Methods In MSF's operational area in Bo and Pujehun districts, Sierra Leone, a retrospective analysis of referral records was carried out for a period of three months. All referral records from CMVs and referral health structures were reviewed, compared and matched for personal data. The eligible study population included febrile children between three and 59 months and pregnant women in their second or third trimester with fever who were noted as having received a referral advice in the CMV recording form. Results The study results showed a total referral rate of almost 15%. During the study period 36 out of 2,459 (1.5%) referred patients completed their referral. There was a significant difference in referral compliance between patients with fever but a negative RDT and patients with signs of severe malaria. Less than 1% (21/2,442) of the RDT-negative patients with fever completed their referral compared to 88.2% (15/17) of the patients with severe malaria (RR = 0.010 95% CI 0.006 - 0.015). Conclusions In this community-based malaria programme, RDT-negative patients with fever were referred to a health structure for further diagnosis and care with a disappointingly low rate of referral completion. This raises concerns whether use of CMVs, with referral as backup in RDT-negative cases, provides adequate care for febrile children and pregnant women. To improve the referral completion in MSF's community-based malaria programme in Sierra Leone, and in similar community-based programmes, a suitable strategy needs to be defined. PMID:21496333

  1. Low referral completion of rapid diagnostic test-negative patients in community-based treatment of malaria in Sierra Leone.

    PubMed

    Thomson, Anna; Khogali, Mohammed; de Smet, Martin; Reid, Tony; Mukhtar, Ahmed; Peterson, Stefan; von Schreeb, Johan

    2011-04-17

    Malaria is hyper-endemic and a major public health problem in Sierra Leone. To provide malaria treatment closer to the community, Médecins Sans Frontières (MSF) launched a community-based project where Community Malaria Volunteers (CMVs) tested and treated febrile children and pregnant women for malaria using rapid diagnostic tests (RDTs). RDT-negative patients and severely ill patients were referred to health facilities. This study sought to determine the referral rate and compliance of patients referred by the CMVs. In MSF's operational area in Bo and Pujehun districts, Sierra Leone, a retrospective analysis of referral records was carried out for a period of three months. All referral records from CMVs and referral health structures were reviewed, compared and matched for personal data. The eligible study population included febrile children between three and 59 months and pregnant women in their second or third trimester with fever who were noted as having received a referral advice in the CMV recording form. The study results showed a total referral rate of almost 15%. During the study period 36 out of 2,459 (1.5%) referred patients completed their referral. There was a significant difference in referral compliance between patients with fever but a negative RDT and patients with signs of severe malaria. Less than 1% (21/2,442) of the RDT-negative patients with fever completed their referral compared to 88.2% (15/17) of the patients with severe malaria (RR = 0.010 95% CI 0.006 - 0.015). In this community-based malaria programme, RDT-negative patients with fever were referred to a health structure for further diagnosis and care with a disappointingly low rate of referral completion. This raises concerns whether use of CMVs, with referral as backup in RDT-negative cases, provides adequate care for febrile children and pregnant women. To improve the referral completion in MSF's community-based malaria programme in Sierra Leone, and in similar community-based programmes, a suitable strategy needs to be defined.

  2. The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster.

    PubMed

    Wiley, Sandra E; Paddock, Mark L; Abresch, Edward C; Gross, Larry; van der Geer, Peter; Nechushtai, Rachel; Murphy, Anne N; Jennings, Patricia A; Dixon, Jack E

    2007-08-17

    The outer mitochondrial membrane protein mitoNEET was discovered as a binding target of pioglitazone, an insulin-sensitizing drug of the thiazolidinedione class used to treat type 2 diabetes (Colca, J. R., McDonald, W. G., Waldon, D. J., Leone, J. W., Lull, J. M., Bannow, C. A., Lund, E. T., and Mathews, W. R. (2004) Am. J. Physiol. 286, E252-E260). We have shown that mitoNEET is a member of a small family of proteins containing a 39-amino-acid CDGSH domain. Although the CDGSH domain is annotated as a zinc finger motif, mitoNEET was shown to contain iron (Wiley, S. E., Murphy, A. N., Ross, S. A., van der Geer, P., and Dixon, J. E. (2007) Proc. Natl. Acad. Sci. U. S. A. 104, 5318-5323). Optical and electron paramagnetic resonance spectroscopy showed that it contained a redox-active pH-labile Fe-S cluster. Mass spectrometry showed the loss of 2Fe and 2S upon cofactor extrusion. Spectroscopic studies of recombinant proteins showed that the 2Fe-2S cluster was coordinated by Cys-3 and His-1. The His ligand was shown to be involved in the observed pH lability of the cluster, indicating that loss of this ligand via protonation triggered release of the cluster. mitoNEET is the first identified 2Fe-2S-containing protein located in the outer mitochondrial membrane. Based on the biophysical data and domain fusion analysis, mitoNEET may function in Fe-S cluster shuttling and/or in redox reactions.

  3. Aplastic Anemia & MDS International Foundation

    MedlinePlus

    ... Seychelles Sierra Leone Singapore Sint Maarten Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the ... Tribute Of Individual Gifts Corporate Sponsorship Invest in Research Diseases Aplastic Anemia Causes Symptoms Diagnosis Types Treatments ...

  4. Find an Eye M.D.

    MedlinePlus

    ... Leone Singapore Sint Maarten Slovakia(Slovak Republic) Slovenia Solomon Islands Somalia South Africa South Georgia South Sudan ... treat all eye diseases. Many ophthalmologists conduct scientific research to improve treatment options and to find cures ...

  5. ARC-2010-ACD10-0052-064

    NASA Image and Video Library

    2010-03-20

    For Inspiration and Recognition of Science and Technology; FIRST Robotics Competition 2010 Silicon Valley Regional held at San Jose State University, San Jose, California Mark Leon, Ames Robotic Alliance fires up the contestants

  6. ARC-2009-ACD09-0049-016

    NASA Image and Video Library

    2009-03-14

    FIRST Robotics Competition 'Lunacy' hosted by NASA at San Jose State University Event Center. For Inspiration and Recognition of Science and Technology let the games begin. with Mark Leon, Ames Research Robotics Alliance Project Lead.

  7. Leon Cooper, Cooper Pairs, and the BCS Theory

    Science.gov Websites

    , psychology, mathematics, engineering, physics, linguistics and computer science. An Institute objective is to pave the way for the next generation of cognitive pharmaceuticals and intelligent systems for use in

  8. Find a Pediatrician or Pediatric Specialist

    MedlinePlus

    ... SENEGAL SERBIA SEYCHELLES SIERRA LEONE SINGAPORE SLOVAKIA SLOVENIA SOLOMON ISLANDS SOMALIA SOMALILAND SOUTH AFRICA SOUTH OSSETIA SPAIN ... Preventive Medicine Psychology/Psychiatry Public Health Pulmonology Radiology Research Rheumatology School Health Sleep Medicine Sports Medicine Surgery ...

  9. Some new traveling wave exact solutions of the (2+1)-dimensional Boiti-Leon-Pempinelli equations.

    PubMed

    Qi, Jian-ming; Zhang, Fu; Yuan, Wen-jun; Huang, Zi-feng

    2014-01-01

    We employ the complex method to obtain all meromorphic exact solutions of complex (2+1)-dimensional Boiti-Leon-Pempinelli equations (BLP system of equations). The idea introduced in this paper can be applied to other nonlinear evolution equations. Our results show that all rational and simply periodic traveling wave exact solutions of the equations (BLP) are solitary wave solutions, the complex method is simpler than other methods, and there exist some rational solutions ur,2 (z) and simply periodic solutions us,2-6(z) which are not only new but also not degenerated successively by the elliptic function solutions. We believe that this method should play an important role for finding exact solutions in the mathematical physics. For these new traveling wave solutions, we give some computer simulations to illustrate our main results.

  10. Collective Sexual Violence in Bosnia and Sierra Leone: A Comparative Case Study Analysis.

    PubMed

    Ten Bensel, Tusty; Sample, Lisa L

    2017-08-01

    Social scientists have long studied the patterns, motivations, and recidivism rates of sexual offenders; however, the majority of prior research has examined rape, where victims are assaulted by a single offender in isolated events. Often overlooked are sexually violent assaults committed during armed conflicts, which often exhibit group-level sexual offending. This oversight could be a result of perceived notions that sexual violence during conflict is a rare or regrettable event; however, it has been documented consistently throughout history. The purpose of this study was to improve our understanding of sexual violence during war by comparing and contrasting preconflict characteristics, conflict framing, and justifications for sexual violence in the Bosnian and Sierra Leone armed conflicts. This greater understanding can then be used to identify factors that may contribute to the collectivization of sexual violence during war.

  11. Sierra Leone's former child soldiers: a follow-up study of psychosocial adjustment and community reintegration.

    PubMed

    Betancourt, Theresa Stichick; Borisova, Ivelina Ivanova; Williams, Timothy Philip; Brennan, Robert T; Whitfield, Theodore H; de la Soudiere, Marie; Williamson, John; Gilman, Stephen E

    2010-01-01

    This is the first prospective study to investigate psychosocial adjustment in male and female former child soldiers (ages 10-18; n = 156, 12% female). The study began in Sierra Leone in 2002 and was designed to examine both risk and protective factors in psychosocial adjustment. Over the 2-year period of follow-up, youth who had wounded or killed others during the war demonstrated increases in hostility. Youth who survived rape not only had higher levels of anxiety and hostility but also demonstrated greater confidence and prosocial attitudes at follow-up. Of the potential protective resources examined, improved community acceptance was associated with reduced depression at follow-up and improved confidence and prosocial attitudes regardless of levels of violence exposure. Retention in school was also associated with greater prosocial attitudes.

  12. vanC Cluster of Vancomycin-Resistant Enterococcus gallinarum BM4174

    PubMed Central

    Arias, Cesar A.; Courvalin, Patrice; Reynolds, Peter E.

    2000-01-01

    Glycopeptide-resistant enterococci of the VanC type synthesize UDP-muramyl-pentapeptide[d-Ser] for cell wall assembly and prevent synthesis of peptidoglycan precursors ending in d-Ala. The vanC cluster of Enterococcus gallinarum BM4174 consists of five genes: vanC-1, vanXYC, vanT, vanRC, and vanSC. Three genes are sufficient for resistance: vanC-1 encodes a ligase that synthesizes the dipeptide d-Ala-d-Ser for addition to UDP-MurNAc-tripeptide, vanXYC encodes a d,d-dipeptidase–carboxypeptidase that hydrolyzes d-Ala-d-Ala and removes d-Ala from UDP-MurNAc-pentapeptide[d-Ala], and vanT encodes a membrane-bound serine racemase that provides d-Ser for the synthetic pathway. The three genes are clustered: the start codons of vanXYC and vanT overlap the termination codons of vanC-1 and vanXYC, respectively. Two genes which encode proteins with homology to the VanS-VanR two-component regulatory system were present downstream from the resistance genes. The predicted amino acid sequence of VanRC exhibited 50% identity to VanR and 33% identity to VanRB. VanSC had 40% identity to VanS over a region of 308 amino acids and 24% identity to VanSB over a region of 285 amino acids. All residues with important functions in response regulators and histidine kinases were conserved in VanRC and VanSC, respectively. Induction experiments based on the determination of d,d-carboxypeptidase activity in cytoplasmic extracts confirmed that the genes were expressed constitutively. Using a promoter-probing vector, regions upstream from the resistance and regulatory genes were identified that have promoter activity. PMID:10817725

  13. Health knowledge and health practices in Makeni, Sierra Leone: a community-based household survey.

    PubMed

    Abdelmalak, Mena J; Ahmed, Bilaal S; Mehta, Khanjan

    2016-05-01

    We characterize health knowledge and practices in urban and rural Makeni, Sierra Leone, drawing comparisons between areas served by community health workers (CHWs) with those that are not. We also inquire about causes of infant and maternal mortality and how they are understood in the local context. Our objective was to provide a baseline understanding of health knowledge and practices in Makeni during the implementation of a CHW program. We conducted 100 household interviews in Makeni City and rural villages in the surrounding area. We compared data between urban and rural areas to identify differences in health knowledge and practices. Our sample size covered 855 individuals. Insecticide treated bednet ownership was lower in urban settings compared to rural populations (58% vs 94%; p<.001). With regards to maternal mortality, most respondents indicated 'no clinic' (lack of clinical care or skipped antenatal care visits) as the primary cause (n=35), followed by bleeding (n=17), 'lack of blood' (anemia) (n=11) and 'will of God' (n=11). This initial survey of health knowledge and practices in rural and urban Makeni, Sierra Leone, highlights some simple opportunities for community health promotion, health education programming and behavioral interventions. Findings will inform future iterations of a CHW training module for community health education. © The Author 2015. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  14. [Effects of reforestation on tree pollen sensitization in inhabitants of Nuevo Leon, Mexico].

    PubMed

    Palma-Gómez, Samuel; González-Díaz, Sandra Nora; Arias-Cruz, Alfredo; Macías-Weinmann, Alejandra; Amaro-Vivian, Laura Elizabeth; Pérez-Vanzzini, Rafael; Gutiérrez-Mujica, José Julio; Yong-Rodríguez, Adrián

    2014-01-01

    Climate change has implications for health, ecology and society. Urban green areas are a key element in the planning of cities, promoting citizen interaction with the environment, as well as health. Lack of planning and design of these areas as well as the selection of ornamental trees can be a trigger of pollen allergy in the surrounding population. Reforestation is among the programs implemented by the government that have an impact on allergy. Environmental reforestation programs do not take into account the allergenic potential of some species. In the last 4 years, the government of Nuevo Leon, Mexico, has planted nearly 18,000 Quercus species trees, in addition to an unknown number of Fraxinus species trees that are listed as tree species with high pollen production. To identify changes in tree pollen sensitization, based on environmental reforestation programs. A retrospective and descriptive study was done in which positive skin prick tests to pollen from trees in the interval of 2010-2014 were analyzed, correlating between tree species used for reforestation and increased sensitivity to the former. A statistically significant increase in pollen sensitization to species with which Nuevo Leon was reforested was found, along with a decrease in sensitization to the species that were not reforested. Reforestation contributes to some extent to the change in the pattern of positive skin tests and may result in more frequent exacerbations of respiratory diseases. It is an activity that should always be regulated and assisted by experts in the according field.

  15. Factors Underlying Ebola Virus Infection Among Health Workers, Kenema, Sierra Leone, 2014-2015.

    PubMed

    Senga, Mikiko; Pringle, Kimberly; Ramsay, Andrew; Brett-Major, David M; Fowler, Robert A; French, Issa; Vandi, Mohamed; Sellu, Josephine; Pratt, Christian; Saidu, Josephine; Shindo, Nahoko; Bausch, Daniel G

    2016-08-15

    Ebola virus disease (EVD) in health workers (HWs) has been a major challenge during the 2014-2015 outbreak. We examined factors associated with Ebola virus exposure and mortality in HWs in Kenema District, Sierra Leone. We analyzed data from the Sierra Leone National Viral Hemorrhagic Fever Database, contact tracing records, Kenema Government Hospital (KGH) staff and Ebola Treatment Unit (ETU) rosters, and burial logs. From May 2014 through January 2015, 600 cases of EVD originated in Kenema District, including 92 (15%) HWs, 66 (72%) of whom worked at KGH. Among KGH medical staff and international volunteers, 18 of 62 (29%) who worked in the ETU developed EVD, compared with 48 of 83 (58%) who worked elsewhere in the hospital. Thirteen percent of HWs with EVD reported contact with EVD patients, while 27% reported contact with other infected HWs. The number of HW EVD cases at KGH declined roughly 1 month after implementation of a new triage system at KGH and the opening of a second ETU within the district. The case fatality ratio for HWs and non-HWs with EVD was 69% and 74%, respectively. The cluster of HW EVD cases in Kenema District is one of the largest ever reported. Most HWs with EVD had potential virus exposure both inside and outside of hospitals. Prevention measures for HWs must address a spectrum of infection risks in both formal and informal care settings as well as in the community. © 2016 World Health Organization; licensee Oxford Journals.

  16. Marginalization of girl mothers during reintegration from armed groups in Sierra Leone.

    PubMed

    Burman, M E; McKay, S

    2007-12-01

    Although the widespread presence of girls who participate in fighting forces is increasingly recognized, they remain a highly marginalized group globally, receiving little attention either during or after armed conflict. This is especially true for "girl mothers," girls who return to communities with children born while members of fighting forces. The concept of marginalization (Hall et al. 1994) is used to examine what happens to girl soldiers, especially girl mothers, in the aftermath of armed conflict when they seek to reintegrate back into their communities. This analysis, as part of a larger study of reintegration of girl mothers, is based on field work with girls who were in fighting forces in northwest Sierra Leone, especially those who returned with children. The type and level of marginalization these girls experience is consistent with the conceptualization of marginalization; however, they lack voice and experience shame and vulnerability. Moreover, economics were fundamentally related to their marginalization. The girls' access to resources was significantly constrained because the area was heavily impacted by the war and because of widespread poverty throughout Sierra Leone. The findings raise important questions about marginalization of girls affected by war. Girls and girl mothers experience an extremely high level of marginalization; however, some aspects are not consistent with the original conceptualization of marginalization. Theory development in nursing needs to incorporate multiple voices, especially those of the very marginalized and be done in such a manner that benefits and empowers.

  17. What goes around comes back around: life narratives and the significance of the past in Donna Leon's Death at La Fenice.

    PubMed

    Domínguez-Rué, Emma

    2014-04-01

    This paper examines the life narratives of characters in Donna Leon's much-celebrated novel Death at La Fenice (1992). In the first of her Brunetti mystery series, Commissario Guido Brunetti investigates the death of the renowned conductor Helmut Wellauer, poisoned during a performance of La Traviata at La Fenice. As his investigation progresses, Brunetti discovers dark secrets in the past of the acclaimed Maestro, revealing his dishonesty and cruelty, but, most shockingly, his involvement in a horrendous case of child abuse and death by neglect. My analysis will address the role of memory and the significance of the past for the present, as the tragic experiences of the Santina sisters in the 1930s become intertwined with those of Wellauer's present wife Elizabeth and her daughter Alexandra. Using literary theory and cultural gerontology as methodological tools, this paper will explore Leon's portrait of the aging process: Wellauer's lack of remorse for his past sins and his inability to cope with impending deafness will be contrasted with the painful account by Wellauer's former lover, the once famous soprano Clemenza Santina, whose narrative response to her traumatic experience renders the past more alive than the present. The significance of memory, as well as the crucial role of life narratives in the personal and cultural construction of identity, will be addressed to interrogate the ways in which our perception of aging can be enriched by literary studies. Copyright © 2014 Elsevier Inc. All rights reserved.

  18. Cone-morse implant connection system significantly reduces bacterial leakage between implant and abutment: an in vitro study.

    PubMed

    Baj, A; Bolzoni, A; Russillo, A; Lauritano, D; Palmieri, A; Cura, F; Silvestre, F J; Giannì, A B

    2017-01-01

    Osseointegrated implants are very popular dental treatments today in the world. In osseointegrated implants, the occlusal forces are transmitted from prosthesis through an abutment to a dental implant. The abutment is connected to the implant by mean of a screw. A screw is the most used mean for connecting an implant to an abutment. Frequently the screws break and are lost. There is an alternative to screw retained abutment systems: the cone-morse connection (CMC). The CMC, thanks to the absence of the abutment screw, guarantees no micro-gaps, no micro-movements, and a reduction of bacterial leakage between implant and abutment. As P. gingivalis and T. forsythia penetration might have clinical relevance, it was the purpose of this investigation to evaluate molecular leakage of these two bacteria in a new CMC implants systems (Leone Spa®, Florence, Italy). To identify the capability of the implant to protect the internal space from the external environment, the passage of genetically modified Escherichia coli across implant-abutment interface was evaluated. Four cone-morse Leone implants (Leone® Spa, Florence, Italy) were immerged in a bacterial culture for 24 h and bacteria amount was then measured inside implant-abutment interface with Real-time PCR. Bacteria were detected inside all studied implants, with a median percentage of 3% for P. gingivalis and 4% for T. forsythia. Cone-morse connection implant system has very low bacterial leakage percentage and is similar to one-piece implants.

  19. Defense.gov Special Report: Leon E. Panetta

    Science.gov Websites

    the Central Intelligence Agency from February 2009 to June 2011. Mr. Panetta led the Agency and managed human intelligence and open source collection programs on behalf of the Intelligence Community

  20. Of Tales and Tempests.

    ERIC Educational Resources Information Center

    Bottoms, Janet

    1996-01-01

    Examines the prose versions of Shakespeare plays written for children by Charles and Mary Lamb, Bernard Miles, and Leon Garfield. Suggests that the content ranges far from Shakespeare's originals and promotes values that should be questioned critically. (TB)

  1. Genetics Home Reference: achromatopsia

    MedlinePlus

    ... NW, Roosing S, van Schooneveld MJ, van Lith-Verhoeven JJ, van Moll-Ramirez N, van den Born LI, ... van Schooneveld MJ, Strom TM, van Lith-Verhoeven JJ, Lotery AJ, van Moll-Ramirez N, Leroy BP, ...

  2. Glycopeptide Resistance vanA Operons in Paenibacillus Strains Isolated from Soil

    PubMed Central

    Guardabassi, Luca; Perichon, Bruno; van Heijenoort, Jean; Blanot, Didier; Courvalin, Patrice

    2005-01-01

    The sequence and gene organization of the van operons in vancomycin (MIC of >256 μg/ml)- and teicoplanin (MIC of ≥32 μg/ml)-resistant Paenibacillus thiaminolyticus PT-2B1 and Paenibacillus apiarius PA-B2B isolated from soil were determined. Both operons had regulatory (vanR and vanS), resistance (vanH, vanA, and vanX), and accessory (vanY, vanZ, and vanW) genes homologous to the corresponding genes in enterococcal vanA and vanB operons. The vanAPT operon in P. thiaminolyticus PT-2B1 had the same gene organization as that of vanA operons whereas vanAPA in P. apiarius PA-B2B resembled vanB operons due to the presence of vanW upstream from the vanHAX cluster but was closer to vanA operons in sequence. Reference P. apiarius strains NRRL B-4299 and NRRL B-4188 were found to harbor operons indistinguishable from vanAPA by PCR mapping, restriction fragment length polymorphism, and partial sequencing, suggesting that this operon was species specific. As in enterococci, resistance was inducible by glycopeptides and associated with the synthesis of pentadepsipeptide peptidoglycan precursors ending in d-Ala-d-Lac, as demonstrated by d,d-dipeptidase activities, high-pressure liquid chromatography, and mass spectrometry. The precursors differed from those in enterococci by the presence of diaminopimelic acid instead of lysine in the peptide chain. Altogether, the results are compatible with the notion that van operons in soil Paenibacillus strains and in enterococci have evolved from a common ancestor. PMID:16189102

  3. Glycopeptide resistance vanA operons in Paenibacillus strains isolated from soil.

    PubMed

    Guardabassi, Luca; Perichon, Bruno; van Heijenoort, Jean; Blanot, Didier; Courvalin, Patrice

    2005-10-01

    The sequence and gene organization of the van operons in vancomycin (MIC of >256 microg/ml)- and teicoplanin (MIC of > or =32 microg/ml)-resistant Paenibacillus thiaminolyticus PT-2B1 and Paenibacillus apiarius PA-B2B isolated from soil were determined. Both operons had regulatory (vanR and vanS), resistance (vanH, vanA, and vanX), and accessory (vanY, vanZ, and vanW) genes homologous to the corresponding genes in enterococcal vanA and vanB operons. The vanA(PT) operon in P. thiaminolyticus PT-2B1 had the same gene organization as that of vanA operons whereas vanA(PA) in P. apiarius PA-B2B resembled vanB operons due to the presence of vanW upstream from the vanHAX cluster but was closer to vanA operons in sequence. Reference P. apiarius strains NRRL B-4299 and NRRL B-4188 were found to harbor operons indistinguishable from vanA(PA) by PCR mapping, restriction fragment length polymorphism, and partial sequencing, suggesting that this operon was species specific. As in enterococci, resistance was inducible by glycopeptides and associated with the synthesis of pentadepsipeptide peptidoglycan precursors ending in D-Ala-D-Lac, as demonstrated by D,D-dipeptidase activities, high-pressure liquid chromatography, and mass spectrometry. The precursors differed from those in enterococci by the presence of diaminopimelic acid instead of lysine in the peptide chain. Altogether, the results are compatible with the notion that van operons in soil Paenibacillus strains and in enterococci have evolved from a common ancestor.

  4. Diversity of Tn1546 in vanA-positive Enterococcus faecium clinical isolates with VanA, VanB, and VanD phenotypes and susceptibility to vancomycin.

    PubMed

    Cha, J O; Yoo, J I; Kim, H K; Kim, H S; Yoo, J S; Lee, Y S; Jung, Y H

    2013-10-01

    To investigate diversity in the vanA cluster in Enterococcus faecium isolates from nontertiary hospitals. We identified 43 vanA-positive Ent. faecium isolates, including two vancomycin-susceptible isolates, from hospitals between 2003 and 2006. Of these isolates, >85% were resistant to ampicillin, erythromycin and ciprofloxacin. The vanA cluster was classified into six types using overlapping PCR, but the prototype transposon Tn1546 was not found. Most vanA-positive vancomycin-resistant Enterococcus (VRE) carried IS1216V and belonged to Type III (58·1%) or Type II (20·9%). vanY, vanZ and IS1216V were observed in the left and right ends of Type III with long-range PCR. IS1216V was also observed within vanS and vanX in the two vancomycin-susceptible isolates and in two vancomycin-resistant isolates. No VRE isolates with VanB and VanD phenotypes contained point mutations in vanS, unlike in previous reports. Sequence types (STs) of all isolates belonged to clonal complex 17, and ST78 was predominant. Insertion sequences, especially IS1216V, cause structural variation in the vanA cluster. We report the first observation of vanY and vanZ at the left end of Tn1546 in clinical isolates. This is the first report of the frequency of vancomycin resistance and diversity of Tn1546 in vanA-positive Ent. faecium isolates from nontertiary hospitals. © 2013 The Society for Applied Microbiology.

  5. OMEGACAM and Gravitational Lensing

    NASA Astrophysics Data System (ADS)

    Christen, Fabrice Frédéric Thiébaut

    2007-04-01

    Het proefschrift van Fabrice Christen gaat over de ontwikkeling van nieuwe methoden voor het corrigeren van (digitale) foto's van melkwegstelsels. Met deze methoden kunnen de beelden uit het heelal beter worden geanalyseerd. Het eerste gedeelte is gewijd aan het werk dat bij ESO is uitgevoerd aan de CCD's van de OmegaCAM camera, het enige instrument van de VST. OmegaCAM is een optische groothoekcamera met een beeldveld van een vierkante graad, opgebouwd uit een mozaiek van 8 bij 4 CCD's. Van elk onderdeel moeten alle kenmerken volledig bekend zijn voordat het in het CCD mozaiek geplaatst kan worden. In het tweede deel van dit proefschrift wordt de ontwikkeling van een nieuwe methode voor het corrigeren van de ``point-spread function'' (PSF) en schatten van de ellipticiteit van de melkwegstelsels besproken. De nieuwe techniek wordt getest en vergeleken met een door sterrenkundigen algemeen gebruikte methode in het veld van zwaartekrachtslenzen, de Kaiser, Squire en Broadhurst (KSB) methode. De nieuwe methode, gebaseerd op shapelet ontleding (vergelijkbaar met wavelet ontleding), gaat verder, en is sneller en theoretisch preciezer dan de KSB methode. Door gebruik te maken van de gecorrigeerde ellipticiteit, kunnen we een statistische analyse uitvoeren om er een kosmisch vervormingssignaal uit te halen. De licht vervormde beelden van de melkwegstelsels bewij zen dat de niet-homogene massaverdeling op megaparsec-schaal voornamelijk bestaat uit grote hoeveelheden donkere materie. Verder vergelijken we de schattingen van de ellipticiteit van de shapelet en KSB methode. Bovendien voeren we ook nog een melkwegstelsel-melkwegstelsel lens analyse uit op de 50 VLT Fors1 afbeeldingen en slagen we erin de belangrijkste eigenschappen van de halo's van de stelsels, die zich op een afstand van een- tot tweeduizend megaparsec (1 parsec = 3,26 lichtjaar = 3,085 x 10^16 meter) bevinden, te bepalen door gebruik te maken van twee modellen van melkwegstelselhalo's. Vergeleken met andere overzichtsmetingen vinden we vergelijkbare resultaten.

  6. Beslisbevoegdheden en Verantwoordelijkheden van de Uitgestegen Soldaat. Deel A: Verplaatsen van Beslisbevoegdheden (Authority and Responsibility of the Dismounted Soldier. Part A. Empowering the Dismounted Soldier)

    DTIC Science & Technology

    2007-04-01

    en verantwoordelijkheden van de uitgestegen soldaat Deel A: verplaatsen van beslisbevoegdheden Datumn april 2007 Auteur (s) R. de Bruin ITE. van Bernmel...Admiraal, Bureau SMP Auteur (s) R. de Bruin Program maleider Projectleider I.E. van Bemnmel dr. W.A. Lotens, A.J. van Vliet, A.J. van Vijet TNO Defensie en...Leadership Theory en wordt relevant geacht voor de ontvangers van aanvullende beslisbevoegdheden. 2.1.3 Het oogmerk van de hogere commandant Een ander

  7. Laredo District Coahuila/Nuevo Leon/Tamaulipas border master plan.

    DOT National Transportation Integrated Search

    2012-06-01

    Border Master Plans document a regions needs and priorities, and recommend a mechanism to ensure coordination on current and planned future port of entry (POE) projects and supporting transportation infrastructure to serve the anticipated demand i...

  8. Defense.gov Special Report: Travels With Panetta

    Science.gov Websites

    , Defense Secretary Leon E. Panetta said in Brussels. Story NATO, Partners Still Considering Size of Post Secretary George Little said. Story NATO Secretary General Pledges New Afghan Mission Post-2014 NATO and its

  9. Lassa Fever

    MedlinePlus

    ... in 1969 when two missionary nurses died in Nigeria. The virus is named after the town in Nigeria where the first cases occurred. The virus, a ... west Africa including Sierra Leone, Liberia, Guinea and Nigeria; however, other neighboring countries are also at risk, ...

  10. Payment deferred: strychnine poisoning in Nicaragua 65 years ago.

    PubMed

    Ferguson, M B; Vance, M A

    2000-01-01

    In 1933 in Leon, Nicaragua, a 22-year-old woman died after an acute convulsive illness in which she experienced trismus, opisthotonos, and hyperpyrexia. Three years later her husband, Oliverio Castaneda, was convicted of her murder and that of 2 other people in the same city. We went to Nicaragua to investigate documents involved with that case and evaluate whether the verdict of murder by strychnine was substantiated by the data. We present the results of the investigation and provide information about the practice of medicine, pharmacy, and toxicology early in this century. The clinical picture in all 3 cases suggests strychnine poisoning. The clinical, toxicological, and circumstantial evidence is strong and implicates Castaneda as a murderer and strychnine as the weapon. We conclude that Oliverio Castaneda was the probable perpetrator of three 1933 strychnine murders in Leon and that he may have previously used strychnine to kill others in Nicaragua and neighboring countries.

  11. Leon Knopoff (1926-2011)

    NASA Astrophysics Data System (ADS)

    Davis, Paul; Jackson, David; Gilbert, Freeman

    2011-06-01

    Leon Knopoff died at his home in Sherman Oaks, Calif., on 20 January 2011 at the age of 85. A man of wide-ranging talents, he had the rare distinction of being simultaneously a professor of physics, a professor of geophysics, and a research musicologist at the University of California, Los Angeles (UCLA). As an undergraduate he studied electrical engineering and obtained his Ph.D. in physics and mathematics at the California Institute of Technology (Caltech) in 1949. He was recruited to the Institute of Geophysics (now the Institute of Geophysics and Planetary Physics) at UCLA in 1950 by Louis Slichter, where he became a professor of geophysics in 1957 and of geophysics and physics in 1961. He became a research musicologist in the UCLA Institute of Ethnomusicology soon after it was formed in 1960. Other appointments included faculty positions at Miami University in Ohio (1948-1950) and Caltech (1962-1963) and visiting appointments at Cambridge, Karlsruhe, Harvard, Santiago, Trieste, and Venice.

  12. Clinical Features of and Risk Factors for Fatal Ebola Virus Disease, Moyamba District, Sierra Leone, December 2014-February 2015.

    PubMed

    Haaskjold, Yngvar Lunde; Bolkan, Håkon Angell; Krogh, Kurt Østhuus; Jongopi, James; Lundeby, Karen Marie; Mellesmo, Sindre; Garcés, Pedro San José; Jøsendal, Ola; Øpstad, Åsmund; Svensen, Erling; Fuentes, Luis Matias Zabala; Kamara, Alfred Sandy; Riera, Melchor; Arranz, Javier; Roberts, David P; Stamper, Paul D; Austin, Paula; Moosa, Alfredo J; Marke, Dennis; Hassan, Shoaib; Eide, Geir Egil; Berg, Åse; Blomberg, Bjørn

    2016-09-01

    The 2013-2016 outbreak of Ebola virus disease (EVD) in West Africa infected >28,000 people, including >11,000 who died, and disrupted social life in the region. We retrospectively studied clinical signs and symptoms and risk factors for fatal outcome among 31 Ebola virus-positive patients admitted to the Ebola Treatment Center in Moyamba District, Sierra Leone. We found a higher rate of bleeding manifestations than reported elsewhere during the outbreak. Significant predictors for death were shorter time from symptom onset to admission, male sex, high viral load on initial laboratory testing, severe pain, diarrhea, bloody feces, and development of other bleeding manifestations during hospitalization. These risk factors for death could be used to identify patients in need of more intensive medical support. The lack of fever in as many as one third of EVD cases may have implications for temperature-screening practices and case definitions.

  13. Depth-dependent groundwater quality sampling at City of Tallahassee test well 32, Leon County, Florida, 2013

    USGS Publications Warehouse

    McBride, W. Scott; Wacker, Michael A.

    2015-01-01

    A test well was drilled by the City of Tallahassee to assess the suitability of the site for the installation of a new well for public water supply. The test well is in Leon County in north-central Florida. The U.S. Geological Survey delineated high-permeability zones in the Upper Floridan aquifer, using borehole-geophysical data collected from the open interval of the test well. A composite water sample was collected from the open interval during high-flow conditions, and three discrete water samples were collected from specified depth intervals within the test well during low-flow conditions. Water-quality, source tracer, and age-dating results indicate that the open interval of the test well produces water of consistently high quality throughout its length. The cavernous nature of the open interval makes it likely that the highly permeable zones are interconnected in the aquifer by secondary porosity features.

  14. Effects of Response to 2014-2015 Ebola Outbreak on Deaths from Malaria, HIV/AIDS, and Tuberculosis, West Africa.

    PubMed

    Parpia, Alyssa S; Ndeffo-Mbah, Martial L; Wenzel, Natasha S; Galvani, Alison P

    2016-03-01

    Response to the 2014-2015 Ebola outbreak in West Africa overwhelmed the healthcare systems of Guinea, Liberia, and Sierra Leone, reducing access to health services for diagnosis and treatment for the major diseases that are endemic to the region: malaria, HIV/AIDS, and tuberculosis. To estimate the repercussions of the Ebola outbreak on the populations at risk for these diseases, we developed computational models for disease transmission and infection progression. We estimated that a 50% reduction in access to healthcare services during the Ebola outbreak exacerbated malaria, HIV/AIDS, and tuberculosis mortality rates by additional death counts of 6,269 (2,564-12,407) in Guinea; 1,535 (522-2,8780) in Liberia; and 2,819 (844-4,844) in Sierra Leone. The 2014-2015 Ebola outbreak was catastrophic in these countries, and its indirect impact of increasing the mortality rates of other diseases was also substantial.

  15. Efforts to Promote Reintegration and Rehabilitation of Traumatized Former Child Soldiers: Reintegration of Former Child Soldiers in Sierra Leone: The Role of Caregivers and Their Awareness of the Violence Adolescents Experienced During the War.

    PubMed

    Borisova, Ivelina I; Betancourt, Theresa S; Willett, John B

    2013-01-01

    This article explores the role of caregivers in the reintegration of former child soldiers from Sierra Leone. Using data on 282 youth and their respective caregivers, our aim is to focus on the caregiver-child relationship after reintegration. We investigate the extent to which caregivers know about child soldiers' experiences of direct and indirect violence, as well as involvement in war activities. We further examine variables that might shape the degree of caregiver knowledge of child's war experiences. Finally, we examine if caregiver knowledge of war experiences is associated with child's psychosocial outcomes. Findings highlight the importance of developing thoughtful programs that consider the needs of the child in the context of the family and caregivers with whom he or she is reunified.

  16. Generalized symmetries of an 𝓝 = 1 supersymmetric Boiti-Leon-Manna-Pempinelli system

    NASA Astrophysics Data System (ADS)

    Wang, Jian-Yong; Tang, Xiao-Yan; Liang, Zu-Feng; Lou, Sen-Yue

    2015-05-01

    The formal series symmetry approach (FSSA), a quite powerful and straightforward method to establish infinitely many generalized symmetries of classical integrable systems, has been successfully extended in the supersymmetric framework to explore series of infinitely many generalized symmetries for supersymmetric systems. Taking the 𝒩 = 1 supersymmetric Boiti-Leon-Manna-Pempinelli system as a concrete example, it is shown that the application of the extended FSSA to this supersymmetric system leads to a set of infinitely many generalized symmetries with an arbitrary function f (t). Some interesting special cases of symmetry algebras are presented, including a limit case f (t) = 1 related to the commutativity of higher order generalized symmetries. Project supported by the National Natural Science Foundation of China (Grant Nos. 11275123, 11175092, 11475052, and 11435005), the Shanghai Knowledge Service Platform for Trustworthy Internet of Things, China (Grant No. ZF1213), and the Talent Fund and K CWong Magna Fund in Ningbo University, China.

  17. Development of a Pediatric Ebola Predictive Score, Sierra Leone1.

    PubMed

    Fitzgerald, Felicity; Wing, Kevin; Naveed, Asad; Gbessay, Musa; Ross, J C G; Checchi, Francesco; Youkee, Daniel; Jalloh, Mohamed Boie; Baion, David E; Mustapha, Ayeshatu; Jah, Hawanatu; Lako, Sandra; Oza, Shefali; Boufkhed, Sabah; Feury, Reynold; Bielicki, Julia; Williamson, Elizabeth; Gibb, Diana M; Klein, Nigel; Sahr, Foday; Yeung, Shunmay

    2018-02-01

    We compared children who were positive for Ebola virus disease (EVD) with those who were negative to derive a pediatric EVD predictor (PEP) score. We collected data on all children <13 years of age admitted to 11 Ebola holding units in Sierra Leone during August 2014-March 2015 and performed multivariable logistic regression. Among 1,054 children, 309 (29%) were EVD positive and 697 (66%) EVD negative, with 48 (5%) missing. Contact history, conjunctivitis, and age were the strongest positive predictors for EVD. The PEP score had an area under receiver operating characteristics curve of 0.80. A PEP score of 7/10 was 92% specific and 44% sensitive; 3/10 was 30% specific, 94% sensitive. The PEP score could correctly classify 79%-90% of children and could be used to facilitate triage into risk categories, depending on the sensitivity or specificity required.

  18. Prevalence of Autism Spectrum Disorders in Guanajuato, Mexico: The Leon survey.

    PubMed

    Fombonne, Eric; Marcin, Carlos; Manero, Ana Cecilia; Bruno, Ruth; Diaz, Christian; Villalobos, Michele; Ramsay, Katrina; Nealy, Benjamin

    2016-05-01

    There are no epidemiological data on autism for Mexico. This study was conducted to generate a first estimate of ASD prevalence in Mexico. We surveyed children age eight in Leon (Guanajuato). The sample was stratified in two strata: (1) children having special education and medical records (SEMR; N = 432) and (2) children attending regular schools (GSS; N = 11,684). GSS children were screened with the SRS and those with the highest scores were invited to a diagnostic evaluation. The final sample comprised 36 children (80.6 % male) who had confirmed ASD. A third had intellectual disability, 25 % were non-verbal, 69 % had co-occurring behavioral problems. The prevalence overall was 0.87 % (95 % CI 0.62, 1.1 %). This survey provides an estimate for ASD prevalence in Mexico that is consistent with recent studies.

  19. Post-Ebola Syndrome, Sierra Leone.

    PubMed

    Scott, Janet T; Sesay, Foday R; Massaquoi, Thomas A; Idriss, Baimba R; Sahr, Foday; Semple, Malcolm G

    2016-04-01

    Thousands of persons have survived Ebola virus disease. Almost all survivors describe symptoms that persist or develop after hospital discharge. A cross-sectional survey of the symptoms of all survivors from the Ebola treatment unit (ETU) at 34th Regimental Military Hospital, Freetown, Sierra Leone (MH34), was conducted after discharge at their initial follow-up appointment within 3 weeks after their second negative PCR result. From its opening on December 1, 2014, through March 31, 2015, the MH34 ETU treated 84 persons (8-70 years of age) with PCR-confirmed Ebola virus disease, of whom 44 survived. Survivors reported musculoskeletal pain (70%), headache (48%), and ocular problems (14%). Those who reported headache had had lower admission cycle threshold Ebola PCR than did those who did not (p<0.03). This complete survivor cohort from 1 ETU enables analysis of the proportion of symptoms of post-Ebola syndrome. The Ebola epidemic is waning, but the effects of the disease will remain.

  20. The relationship among the resiliency practices in supply chain, financial performance, and competitive advantage in manufacturing firms in Indonesia and Sierra Leone

    NASA Astrophysics Data System (ADS)

    Musa, I.; Nyoman Pujawan, I.

    2018-04-01

    Current supply chain management (SCM) has become a potentially treasured way of safeguarding competitive advantage and improving organizational performance since competition is no longer between organizations, but among supply chains. This research conceptualizes and develops four resiliency practices (Flexibility, Redundancy, Collaboration and Agility) and tests the relationships between organizations’ financial performance and competitive advantage in manufacturing firms. The study involves manufacturing firms in Indonesia and Sierra Leone. The study used stratified random sampling to pick a sample size of 95 manufacturing firms, which represented different industrial sectors. The respondents were mainly managers of different manufacturing companies. The relationships proposed in the conceptual framework were tested using correlation analysis. The results indicate that higher levels of resilience practices in manufacturing firms can lead to enhanced competitive advantage and improved financial performance.

  1. Global health business: the production and performativity of statistics in Sierra Leone and Germany.

    PubMed

    Erikson, Susan L

    2012-01-01

    The global push for health statistics and electronic digital health information systems is about more than tracking health incidence and prevalence. It is also experienced on the ground as means to develop and maintain particular norms of health business, knowledge, and decision- and profit-making that are not innocent. Statistics make possible audit and accountability logics that undergird the management of health at a distance and that are increasingly necessary to the business of health. Health statistics are inextricable from their social milieus, yet as business artifacts they operate as if they are freely formed, objectively originated, and accurate. This article explicates health statistics as cultural forms and shows how they have been produced and performed in two very different countries: Sierra Leone and Germany. In both familiar and surprising ways, this article shows how statistics and their pursuit organize and discipline human behavior, constitute subject positions, and reify existing relations of power.

  2. Ebola Virus Disease in Children, Sierra Leone, 2014–2015

    PubMed Central

    Naveed, Asad; Wing, Kevin; Gbessay, Musa; Ross, J.C.G.; Checchi, Francesco; Youkee, Daniel; Jalloh, Mohammed Boie; Baion, David; Mustapha, Ayeshatu; Jah, Hawanatu; Lako, Sandra; Oza, Shefali; Boufkhed, Sabah; Feury, Reynold; Bielicki, Julia A.; Gibb, Diana M.; Klein, Nigel; Sahr, Foday; Yeung, Shunmay

    2016-01-01

    Little is known about potentially modifiable factors in Ebola virus disease in children. We undertook a retrospective cohort study of children <13 years old admitted to 11 Ebola holding units in the Western Area, Sierra Leone, during 2014–2015 to identify factors affecting outcome. Primary outcome was death or discharge after transfer to Ebola treatment centers. All 309 Ebola virus–positive children 2 days–12 years old were included; outcomes were available for 282 (91%). Case-fatality was 57%, and 55% of deaths occurred in Ebola holding units. Blood test results showed hypoglycemia and hepatic/renal dysfunction. Death occurred swiftly (median 3 days after admission) and was associated with younger age and diarrhea. Despite triangulation of information from multiple sources, data availability was limited, and we identified no modifiable factors substantially affecting death. In future Ebola virus disease epidemics, robust, rapid data collection is vital to determine effectiveness of interventions for children. PMID:27649367

  3. A distinctive dual-channel quorum-sensing system operates in Vibrio anguillarum.

    PubMed

    Croxatto, Antony; Pride, John; Hardman, Andrea; Williams, Paul; Cámara, Miguel; Milton, Debra L

    2004-06-01

    Many bacterial cells communicate using diffusible signal molecules to monitor cell population density via a process termed quorum sensing. In marine Vibrio species, the Vibrio harveyi-type LuxR protein is a key player in a quorum-sensing phosphorelay cascade, which controls the expression of virulence, symbiotic and survival genes. Previously, we characterized Vibrio anguillarum homologues of LuxR (VanT) and LuxMN (VanMN) and, in this study, we have identified homologues of LuxPQ (VanPQ) and LuxOU (VanOU). In contrast to other Vibrio species, vanT was expressed at low cell density and showed no significant induction as the cell number increased. In addition, although the loss of VanO increased vanT expression, the loss of VanU, unexpectedly, decreased it. Both VanN and VanQ were required for repression of vanT even in a vanU mutant, suggesting an alternative route for VanNQ signal transduction other than via VanU. VanT negatively regulated its own expression by binding and repressing the vanT promoter and by binding and activating the vanOU promoter. The signal relay results in a cellular response as expression of the metalloprotease, empA, was altered similar to that of vanT in all the mutants. Consequently, the V. anguillarum quorum-sensing phosphorelay systems work differently from those of V. harveyi and may be used to limit rather than induce vanT expression.

  4. Dutch Anthropometry for Vehicle Design and Evaluation

    DTIC Science & Technology

    2008-10-01

    middelen Beschrijving van de werkzaamheden Uitgaande van afmetingen van Nederlanders zijn grenswaarden voor negen paspoppen. met vanSrende...vastgesteld voor het jaar 2015 Hierbij is uitgegaan van een Nederlands antropometrisch bestand (NedScan) Resultaten en conclusies Het resultaat is een kort... Nederlands antropometrisch bestand (NedScan) en van lichaamsafmetingen van goedgekeurde K.L rekruten. De grenswaarden omvatten 95% van dat Nederlandse

  5. 19 CFR 10.41a - Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Lift vans, cargo vans, shipping tanks, skids... Traffic § 10.41a Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international traffic; repair components. (a)(1) Lift vans, cargo vans, shipping tanks, skids, pallets, caul...

  6. 19 CFR 10.41a - Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Lift vans, cargo vans, shipping tanks, skids... Traffic § 10.41a Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international traffic; repair components. (a)(1) Lift vans, cargo vans, shipping tanks, skids, pallets, caul...

  7. Fast Determination of the Element Excitation of an Active Phased Array Antenna

    DTIC Science & Technology

    1991-03-01

    elementenexcitatie te, bepalen: de amplitude en fase van het elektrische ven-e veld moeten gemeten warden in slechts I richting in het verre veld van de ...Page 3 rapport no FEL-91-BO38 titel Een snelle bepaling van de excitatie van de elenienten van cen actieve phased array antenne auteur(s) I. J.G. van...van der Spek Onderzoek uItgevoerd door Ir. J.G. van Hezewijk SAMENVATIING (ONGERUBRICEERD) Het verre veld stralingsdiagram van een actieve phased array

  8. Kimberlites of the Man craton, West Africa

    NASA Astrophysics Data System (ADS)

    Skinner, E. M. W.; Apter, D. B.; Morelli, C.; Smithson, N. K.

    2004-09-01

    The Man craton in West Africa is an Archaean craton formerly joined to the Guyana craton (South America) that was rifted apart in the Mesozoic. Kimberlites of the Man craton include three Jurassic-aged clusters in Guinea, two Jurassic-aged clusters in Sierra Leone, and in Liberia two clusters of unknown age and one Neoproterozoic cluster recently dated at ∼800 Ma. All of the kimberlites irrespective of age occur as small pipes and prolific dykes. Some of the Banankoro cluster pipes in Guinea, the Koidu pipes in Sierra Leone and small pipes in the Weasua cluster in Liberia contain hypabyssal-facies kimberlite and remnants of the so-called transitional-facies and diatreme-facies kimberlite. Most of the Man craton kimberlites are mineralogically classified as phlogopite kimberlites, although potassium contents are relatively low. They are chemically similar to mica-poor Group 1A Southern African examples. The Jurassic kimberlites are considered to represent one province of kimberlites that track from older bodies in Guinea (Droujba 153 Ma) to progressively younger kimberlites in Sierra Leone (Koidu, 146 Ma and Tongo, 140 Ma). The scarcity of diatreme-facies kimberlites relative to hypabyssal-facies kimberlites and the presence of the so-called transitional-facies indicate that the pipes have been eroded down to the interface between the root and diatreme zones. From this observation, it is concluded that extensive erosion (1-2 km) has occurred since the Jurassic. In addition to erosion, the presence of abundant early crystallizing phlogopite is considered to have had an effect on the relatively small sizes of the Man craton kimberlites.

  9. The Surgical Workforce and Surgical Provider Productivity in Sierra Leone: A Countrywide Inventory.

    PubMed

    Bolkan, Håkon A; Hagander, Lars; von Schreeb, Johan; Bash-Taqi, Donald; Kamara, Thaim B; Salvesen, Øyvind; Wibe, Arne

    2016-06-01

    Limited data exist on surgical providers and their scope of practice in low-income countries (LICs). The aim of this study was to assess the distribution and productivity of all surgical providers in an LIC, and to evaluate correlations between the surgical workforce availability, productivity, rates, and volume of surgery at the district and hospital levels. Data on surgeries and surgical providers from 56 (93.3 %) out of 60 healthcare facilities providing surgery in Sierra Leone in 2012 were retrieved between January and May 2013 from operation theater logbooks and through interviews with key informants. The Sierra Leonean surgical workforce consisted of 164 full-time positions, equal to 2.7 surgical providers/100,000 inhabitants. Non-specialists performed 52.8 % of all surgeries. In rural areas, the densities of specialists and physicians were 26.8 and 6.3 times lower, respectively, compared with urban areas. The average individual productivity was 2.8 surgeries per week, and varied considerably between the cadres of surgical providers and locations. When excluding four centers that only performed ophthalmic surgery, there was a positive correlation between a facility's volume of surgery and the productivity of its surgical providers (r s = 0.642, p < 0.001). Less than half of all of the surgery in Sierra Leone is performed by specialists. Surgical providers were significantly more productive in healthcare facilities with higher volumes of surgery. If all surgical providers were as productive as specialists in the private non-profit sector (5.1 procedures/week), the national volume of surgery would increase by 85 %.

  10. National survey of Ebola-related knowledge, attitudes and practices before the outbreak peak in Sierra Leone: August 2014

    PubMed Central

    Jalloh, Mohamed F; Sengeh, Paul; Monasch, Roeland; Jalloh, Mohammad B; DeLuca, Nickolas; Dyson, Meredith; Golfa, Sheku; Sakurai, Yukiko; Conteh, Lansana; Sesay, Samuel; Brown, Vance; Li, Wenshu; Mermin, Jonathan; Bunnell, Rebecca

    2017-01-01

    Background The 2014–2015 Ebola epidemic in West Africa was the largest ever to occur. In the early phases, little was known about public knowledge, attitudes and practices (KAP) relating to Ebola virus disease (Ebola). Data were needed to develop evidence-driven strategies to address gaps in knowledge and practice. Methods In August 2014, we conducted interviews with 1413 randomly selected respondents from 9 out of 14 districts in Sierra Leone using multistage cluster sampling. Where suitable, Ebola-related KAP questions were adapted from other internationally validated questionnaires related to infectious diseases. Results All respondents were aware of Ebola. When asked unprompted, 60% of respondents could correctly cite fever, diarrhoea and vomiting as signs/symptoms of Ebola. A majority of respondents knew that avoiding infected blood and bodily fluids (87%) and contact with an infected corpse (85%) could prevent Ebola. However, there were also widespread misconceptions such as the belief that Ebola can be prevented by washing with salt and hot water (41%). Almost everyone interviewed (95%) expressed at least one discriminatory attitude towards Ebola survivors. Unprompted, self-reported actions taken to avoid Ebola infection included handwashing with soap (66%) and avoiding physical contact with patients with suspected Ebola (40%). Conclusion Three months into the 2014 Ebola outbreak in Sierra Leone, our findings suggest there was high awareness of the disease but misconceptions and discriminatory attitudes toward survivors remained common. These findings directly informed the development of a national social mobilisation strategy and demonstrated the importance of KAP assessment early in an epidemic. PMID:29259820

  11. Factors Underlying Ebola Virus Infection Among Health Workers, Kenema, Sierra Leone, 2014–2015

    PubMed Central

    Senga, Mikiko; Pringle, Kimberly; Ramsay, Andrew; Brett-Major, David M.; Fowler, Robert A.; French, Issa; Vandi, Mohamed; Sellu, Josephine; Pratt, Christian; Saidu, Josephine; Shindo, Nahoko; Bausch, Daniel G.

    2016-01-01

    Background. Ebola virus disease (EVD) in health workers (HWs) has been a major challenge during the 2014–2015 outbreak. We examined factors associated with Ebola virus exposure and mortality in HWs in Kenema District, Sierra Leone. Methods. We analyzed data from the Sierra Leone National Viral Hemorrhagic Fever Database, contact tracing records, Kenema Government Hospital (KGH) staff and Ebola Treatment Unit (ETU) rosters, and burial logs. Results. From May 2014 through January 2015, 600 cases of EVD originated in Kenema District, including 92 (15%) HWs, 66 (72%) of whom worked at KGH. Among KGH medical staff and international volunteers, 18 of 62 (29%) who worked in the ETU developed EVD, compared with 48 of 83 (58%) who worked elsewhere in the hospital. Thirteen percent of HWs with EVD reported contact with EVD patients, while 27% reported contact with other infected HWs. The number of HW EVD cases at KGH declined roughly 1 month after implementation of a new triage system at KGH and the opening of a second ETU within the district. The case fatality ratio for HWs and non-HWs with EVD was 69% and 74%, respectively. Conclusions. The cluster of HW EVD cases in Kenema District is one of the largest ever reported. Most HWs with EVD had potential virus exposure both inside and outside of hospitals. Prevention measures for HWs must address a spectrum of infection risks in both formal and informal care settings as well as in the community. PMID:27193749

  12. 'Even when you are afraid, you stay': Provision of maternity care during the Ebola virus epidemic: A qualitative study.

    PubMed

    Jones, Susan; Sam, Betty; Bull, Florence; Pieh, Steven Bagie; Lambert, Jaki; Mgawadere, Florence; Gopalakrishnan, Somasundari; Ameh, Charles A; van den Broek, Nynke

    2017-09-01

    to explore nurse-midwives understanding of their role in and ability to continue to provide routine and emergency maternity services during the time of the Ebola virus disease epidemic in Sierra Leone. a hermenuetic phenomenological approach was used to discover the lived experiences of nurse-midwives through 66 face to face interviews. Following verbatim transcription, an iterative approach to data analysis was adopted using framework analysis to discover the essence of the lived experience. health facilities designated to provide maternity care across all 14 districts of Sierra Leone. nurses, midwives, medical staff and managers providing maternal and newborn care during the Ebola epidemic in facilities designated to provide basic or emergency obstetric care. the healthcare system in Sierra Leone was ill prepared to cope with the epidemic. Fear of Ebola and mistrust kept women from accessing care at a health facility. Healthcare providers continued to provide maternity care because of professional duty, responsibility to the community and religious beliefs. nurse-midwives faced increased risks of catching Ebola compared to other health workers but continued to provide essential maternity care. future preparedness plans must take into account the impact that epidemics have on the ability of the health system to continue to provide vital routine and emergency maternal and newborn health care. Healthcare providers need to have a stronger voice in health system rebuilding and planning and management to ensure that health service can continue to provide vital maternal and newborn care during epidemics. Copyright © 2017 The Author. Published by Elsevier Ltd.. All rights reserved.

  13. Mapping deforestation and urban expansion in Freetown, Sierra Leone, from pre- to post-war economic recovery.

    PubMed

    Mansaray, Lamin R; Huang, Jingfeng; Kamara, Alimamy A

    2016-08-01

    Freetown, the capital of Sierra Leone has experienced vast land-cover changes over the past three decades. In Sierra Leone, however, availability of updated land-cover data is still a problem even for environmental managers. This study was therefore, conducted to provide up-to-date land-cover data for Freetown. Multi-temporal Landsat data at 1986, 2001, and 2015 were obtained, and a maximum likelihood supervised classification was employed. Eight land-cover classes or categories were recognized as follows: water, wetland, built-up, dense forest, sparse forest, grassland, barren, and mangrove. Land-cover changes were mapped via post-classification change detection. The persistence, gain, and loss of each land-cover class, and selected land conversions were also quantified. An overall classification accuracy of 87.3 % and a Kappa statistic of 0.85 were obtained for the 2015 map. From 1986 to 2015, water, built-up, grassland, and barren had net gains, whereas forests, wetlands, and mangrove had net loses. Conversion analyses among forests, grassland, and built-up show that built-up had targeted grassland and avoided forests. This study also revealed that, the overall land-cover change at 2001-2015 was higher (28.5 %) than that recorded at 1986-2001 (20.9 %). This is attributable to the population increase in Freetown and the high economic growth and infrastructural development recorded countrywide after the civil war. In view of the rapid land-cover change and its associated environmental impacts, this study recommends the enactment of policies that would strike a balance between urbanization and environmental sustainability in Freetown.

  14. Community-based birth waiting homes in Northern Sierra Leone: Factors influencing women's use.

    PubMed

    Kyokan, Michiko; Whitney-Long, Melissa; Kuteh, Mabel; Raven, Joanna

    2016-08-01

    to explore the factors influencing women's use of birth waiting homes in the Northern Bombali district, Sierra Leone. this was a descriptive exploratory study using qualitative research methodology, which included in depth interviews, key informant interviews, focus group discussions, document review and observations. two chiefdoms in the Northern Bombali district, Sierra Leone. eight interviews were conducted with women who had delivered in the past one year and used birth waiting homes; eight key informant interviews with a project manager, birth waiting homes hosts, and community members; thirteen women who delivered in the past year without using birth waiting homes (four interviews and two focus group discussions). there are several factors influencing the use of birth waiting homes (BWHs) including: past experience of childbirth, promotion of the birth waiting homes by traditional birth attendance, distance and costs of transport to the homes, child care and other family commitments, family's views of the importance of the homes, the costs of food during women's stay, and information given to women and families about when and how to use the homes. some barriers, especially those related to family commitments and costs of food, are challenging to solve. In order to make a BWH a user-friendly and viable option, it may be necessary to adjust ways in which BWHs are used. Good linkage with the health system is strength of the programme. However, further strengthening of community participation in monitoring and managing the BWHs is needed for the long term success and sustainability of the BWHs. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Paediatric care in relation to the 2014–2015 Ebola outbreak and general reporting of deaths in Sierra Leone

    PubMed Central

    Denisiuk, O.; Shringarpure, K. K.; Wurie, B. S.; George, P.; Sesay, M. I.; Zachariah, R.

    2017-01-01

    Setting: All peripheral health units countrywide in Sierra Leone and one hospital in Port Loko. Objectives: Sierra Leone was severely affected by the 2014–2015 Ebola outbreak, whose impact on paediatric care and mortality reports merits assessment. We sought to compare the periods before, during and after the Ebola outbreak, the countrywide trend in morbidities in children aged < 5 years and exit outcomes in one district hospital (Port Loko). During the Ebola outbreak period, gaps in district death reporting within the routine Health Management Information System (HMIS) were compared with the Safe and Dignified Burials (SDB) database in Port Loko. Design: This was a retrospective records analysis. Results: The average number of monthly consultations during the Ebola outbreak period declined by 27% for malaria and acute respiratory infections and 38% for watery diarrhoea, and did not recover to the pre-Ebola levels. For measles, there was an 80% increase during Ebola, which multiplied by 6.5-fold post-Ebola. The number of unfavourable hospital exit outcomes was 52/397 (13%) during Ebola, which was higher than pre-Ebola (47/496, 9%, P = 0.04). Of 6565 deaths reported in the Port Loko SDB database, only 2219 (34%) appeared in the HMIS, a reporting deficit of 66%. Conclusion: The Ebola disease outbreak was associated with reduced utilisation of health services, and appears to have triggered a measles epidemic. Almost 70% of deaths were missed by the HMIS during the Ebola outbreak period. These findings could guide health system responses in future outbreaks. PMID:28744437

  16. Quantifying the risk of nosocomial infection within Ebola Holding Units: a retrospective cohort study of negative patients discharged from five Ebola Holding Units in Western Area, Sierra Leone.

    PubMed

    Arkell, Paul; Youkee, Daniel; Brown, Colin S; Kamara, Abdul; Kamara, Thaim B; Johnson, Oliver; Lado, Marta; George, Viginia; Koroma, Fatmata; King, Matilda B; Parker, Benson E; Baker, Peter

    2017-01-01

    A central pillar in the response to the 2014 Ebola virus disease (EVD) epidemic in Sierra Leone was the role of Ebola Holding Units (EHUs). These units isolated patients meeting a suspect case definition, tested them for EVD, initiated appropriate early treatment and discharged negative patients to onward inpatient care or home. Positive patients were referred to Ebola Treatment Centres. We aimed to estimate the risk of nosocomial transmission within these EHUs. We followed up a cohort of 543 patients discharged with a negative EVD test from five EHUs in the Western Area, Sierra Leone, and examined all line-listed subsequent EVD tests from any facility in the Western Area to see whether the patient was retested within 30 days, matching by name, age and address. We defined possible readmissions as having the same name and age but uncertain address, and confirmed readmissions where name, age and address matched. We found a positive readmission rate of 3.3% (18 cases), which included 1.5% confirmed readmissions (8 cases) and 1.8% possible readmissions (10 cases). This is lower than rates previously reported. We cannot ascertain whether EVD was acquired within the EHUs or from re-exposure in the community. No demographic or clinical variables were identified as risk factors for positive readmission, likely due to our small sample size. These findings support the EHU model as a safe method for isolation of suspect EVD patients and their role in limiting the spread of EVD. © 2016 John Wiley & Sons Ltd.

  17. Amino acid substitutions in the VanS sensor of the VanA-type vancomycin-resistant Enterococcus strains result in high-level vancomycin resistance and low-level teicoplanin resistance.

    PubMed

    Hashimoto, Y; Tanimoto, K; Ozawa, Y; Murata, T; Ike, Y

    2000-04-15

    The vancomycin-resistant enterococci GV1, GV2 and GV3, which were isolated from droppings from broiler farms in Japan have been characterized as VanA-type VRE, which express high-level vancomycin resistance (256 or 512 microg ml(-1), MIC) and low-level teicoplanin resistance (1 or 2 microg ml(-1), MIC). The vancomycin resistances were encoded on plasmids. The vancomycin resistance conjugative plasmid pMG2 was isolated from the GV2 strain. The VanA determinant of pMG2 showed the same genetic organization as that of the VanA genes encoded on the representative transposon Tn1546, which comprises vanRSHAXYZ. The nucleotide sequences of all the genes, except the gene related to the vanS gene on Tn1546, were completely identical to the genes encoded on Tn1546. Three amino acid substitutions in the N-terminal region of the deduced VanS were detected in the nucleotide sequence of vanS encoded on pMG2. There were also three amino acid substitutions in the vanS gene of the GV1 and GV3 strains in the same positions as in the vanS gene of pMG2. Vancomycin induced the increased teicoplanin resistance in these strains.

  18. Presence of the vancomycin resistance gene cluster vanC1, vanXYc, and vanT in Enterococcus casseliflavus.

    PubMed

    Hölzel, Christina; Bauer, Johann; Stegherr, Eva-Maria; Schwaiger, Karin

    2014-04-01

    The three chromosomally located clustered genes vanC1, vanXYc, and vanT confer intrinsic resistance to vancomycin and are used for species identification of Enterococcus gallinarum. In this study, 28 strains belonging to the E. gallinarum/casseliflavus group isolated from cloacal swabs from laying hens were screened for the presence of vanC1. As confirmed by species-specific multiplex PCR, 11 vanC1-positive strains were identified as E. gallinarum. Surprisingly, one yellow pigmented strain, verified as E. casseliflavus by species-specific multiplex PCR, was also vanC1 positive; vanXYc and vanT were additionally detectable in this strain. To our knowledge, this is the first report of vanC1, vanXYc, and vanT in E. casseliflavus. The minimum inhibitory concentration of vancomycin was 4 mg/L. Real-time reverse transcription-PCR revealed that none of the clustered genes was expressed in this strain. Even if the genes seem not to be active, there is a certain risk that they will be transferred to other bacteria where they might be functionally expressed. Therefore, it may be advisable to expand the search for vanC1, vanXYc, and vanT from E. gallinarum to other (enterococcal) species. This study confirms that enterococci live up to their name as being reservoir bacteria and should therefore always be closely monitored.

  19. The Project Dimension in Community Education.

    ERIC Educational Resources Information Center

    Thompson, J. D. Ekundaye

    1994-01-01

    Describes three projects sponsored by the International Community Education Association: (1) functional literacy for railway workers in Ghana; (2) youth farmers' community development project in Ghana; and (3) participatory research in a community education and development network in Sierra Leone. (SK)

  20. Genetics Home Reference: Adams-Oliver syndrome

    MedlinePlus

    ... Baveja R, Silva ES, Dixon J, Leon EL, Solomon BD, Glusman G, Niederhuber JE, Roach JC, Patel MS. Mutations in NOTCH1 cause Adams-Oliver syndrome. Am J Hum Genet. 2014 Sep 4;95(3):275-84. doi: 10.1016/j. ...

  1. The Application of Piagetian and Neo-Piagetian Ideas to Further and Higher Education.

    ERIC Educational Resources Information Center

    Sutherland, Peter

    1999-01-01

    Outlines theoretical perspectives of neo-Piagetians (Kohlberg, Peel, Labouvie-Vief), synthesizers (Kolb, Biggs, Pascual-Leone), and alternative theorists (Perry, Gilligan). Considers their applicability to adults and the implications for adult and higher education. (SK)

  2. 10 things you may not know about superconductivity | Argonne National

    Science.gov Websites

    , Vitaly N. Ginzburg and Anthony J. Leggett for pioneering contributions to the theory of superconductors low temperature. 1972 - John Bardeen, Leon N. Cooper and J. Robert Schreiffer for theory of

  3. Leon M. Lederman Science Education Center: General Information

    Science.gov Websites

    field trips. Location: Located at Fermilab about 35 miles west of Chicago, the Center is easily accessible from the Fermilab main entrance at Kirk Road and Pine Street in Batavia, just three miles north of

  4. Genetics Home Reference: Canavan disease

    MedlinePlus

    ... 884-8. doi: 10.1002/ana.24392. Epub 2015 Mar 27. Citation on PubMed Janson CG, McPhee SW, Francis J, Shera D, Assadi M, Freese A, Hurh P, Haselgrove J, Wang DJ, Bilaniuk L, Leone P. Natural history of ...

  5. Activities of the ILO.

    ERIC Educational Resources Information Center

    Labour Education, 1984

    1984-01-01

    Seven articles on International Labour Organization (ILO) activities cover study groups at ILO headquarters, a Philippine rural workers seminar, women's participation in Central American union activities, worksite courses in India, and seminars and symposia in Cape Verde, Mauritius, and Sierra Leone. (SK)

  6. Defense.gov Special Report: Travels with Panetta - May 2012

    Science.gov Websites

    Pakistan on Safe Havens The United States is reaching the limits of its patience with Pakistan serving as a safe haven for terrorists attacking American forces in Afghanistan, U.S. Defense Secretary Leon E

  7. 77 FR 41447 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... Sierra Vista Dr., Redlands, 12000442 San Diego County Lafayette Hotel, 2223 El Cajon Blvd., San Diego... District (Boundary Increase), Roughly bounded by Avenidas Munoz Rivera & Ponce de Leon, Paseo de Covadonga...

  8. Impact of five annual rounds of mass drug administration with ivermectin on onchocerciasis in Sierra Leone.

    PubMed

    Koroma, Joseph B; Sesay, Santigie; Conteh, Abdul; Koudou, Benjamin; Paye, Jusufu; Bah, Mohamed; Sonnie, Mustapha; Hodges, Mary H; Zhang, Yaobi; Bockarie, Moses J

    2018-04-06

    Onchocerciasis is endemic in 12 of the 14 health districts of Sierra Leone. Good treatment coverage of community-directed treatment with ivermectin was achieved between 2005 and 2009 after the 11-year civil conflict. Sentinel site surveys were conducted in 2010 to evaluate the impact of five annual rounds of ivermectin distribution. In total, 39 sentinel villages from hyper- and meso-endemic areas across the 12 endemic districts were surveyed using skin snips in 2010. Results were analyzed and compared with the baseline data from the same 39 villages. The average microfilaridermia (MF) prevalence across 39 sentinel villages was 53.10% at baseline. The MF prevalence was higher in older age groups, with the lowest in the age group of 1-9 years (11.00%) and the highest in the age group of 40-49 years (82.31%). Overall mean MF density among the positives was 28.87 microfilariae (mf)/snip, increasing with age with the lowest in the age group of 1-9 years and the highest in the age group of 40-49 years. Males had higher MF prevalence and density than females. In 2010 after five rounds of mass drug administration, the overall MF prevalence decreased by 60.26% from 53.10% to 21.10%; the overall mean MF density among the positives decreased by 71.29% from 28.87 mf/snip to 8.29 mf/snip; and the overall mean MF density among all persons examined decreased by 88.58% from 15.33 mf/snip to 1.75 mf/snip. Ten of 12 endemic districts had > 50% reduction in MF prevalence. Eleven of 12 districts had ≥50% reduction in mean MF density among the positives. A significant reduction of onchocerciasis MF prevalence and mean density was recorded in all 12 districts of Sierra Leone after five annual MDAs with effective treatment coverage. The results suggested that the onchocerciasis elimination programme in Sierra Leone was on course to reach the objective of eliminating onchocerciasis in the country by the year 2025. Annual MDA with ivermectin should continue in all 12 districts and further evaluations are needed across the country to assist the NTDP with programme decision making.

  9. The Local Group in LCDM - Shapes and masses of dark halos

    NASA Astrophysics Data System (ADS)

    Vera-Ciro, Carlos Andrés

    2013-01-01

    In dit proefschrift bestuderen we de eigenschappen van donkere materie halo's in het LCDM paradigma. Het eerste deel richt zich op de vorm van de massadistributie van dergelijke objecten. We hebben gevonden dat de vorm van ge"isoleerde Melkweg-achtige donkere materie halo's significant afwijkt van bolsymmetrie. De lokale omgeving heeft invloed op de halo's en deze worden daarbij sterk be"invloed door de manier waarop massa aangroeit. We hebben ook de structuur en de baanstructuur van de satellieten van dergelijke halo's in detail onderzocht. In het algemeen zijn deze objecten sferischer dan de halo's zelf. Ze vertonen ook duidelijke afdrukken van getijdenwerking in zowel hun geometrische vorm als in de baanstructuur. Daarna gebruiken we het aantal massieve objecten rond de Melkweg om limieten te zetten op de totale massa van de donkere materie halo van de Melkweg. De eigenschappen van de massaverdeling van de Melkweg worden verder onderzocht in het laatste hoofdstuk. Daar maken we gebruik van de Sagittarius sterstroom om de vorm van de galactische potentiaal beter te bepalen. We komen met een nieuw model dat rekening houdt met de galactische schijf en de invloed van satellietstelsels en die bovendien consistent is met het LCDM paradigma.

  10. Co-colonization of vanA and vanB Enterococcus faecium of clonal complex 17 in a patient with bacteremia due to vanA E. faecium.

    PubMed

    Seol, Chang Ahn; Park, Jeong Su; Sung, Heungsup; Kim, Mi-Na

    2014-06-01

    A 53-year-old Vietnamese man with liver cirrhosis was transferred from a Vietnamese hospital to our tertiary care hospital in Korea in order to undergo a liver transplantation. Bacteremia due to vanA Enterococcus faecium was diagnosed, and stool surveillance cultures for vancomycin-resistant enterococci (VRE) were positive for both vanA and vanB E. faecium. Pulsed-field gel electrophoresis analysis revealed that the 2 vanA VRE isolates from the blood and stool were clonal, but the vanB VRE was unrelated to the vanA VRE. vanA and vanB VRE were ST64 and ST18, single-allele variations of clonal complex 17, respectively. This is the first case report of vanA VRE bacteremia in a Vietnamese patient and demonstrates the reemergence of vanB VRE since a single outbreak occurred 15years ago in Korea. The reemergence of vanB VRE emphasizes the importance of VRE genotyping to prevent the spread of new VRE strains. Copyright © 2014 Elsevier Inc. All rights reserved.

  11. Biochemical and Genetic Characterization of the vanC-2 Vancomycin Resistance Gene Cluster of Enterococcus casseliflavus ATCC 25788

    PubMed Central

    Dutta, Ireena; Reynolds, Peter E.

    2002-01-01

    The vanC-2 cluster of Enterococcus casseliflavus ATCC 25788 consisted of five genes (vanC-2, vanXYC-2, vanTC-2, vanRC-2, and vanSC-2) and shared the same organization as the vanC cluster of E. gallinarum BM4174. The proteins encoded by these genes displayed a high degree of amino acid identity to the proteins encoded within the vanC gene cluster. The putative d,d-dipeptidase-d,d-carboxypeptidase, VanXYC-2, exhibited 81% amino acid identity to VanXYC, and VanTC-2 displayed 65% amino acid identity to the serine racemase, VanT. VanRC-2 and VanSC-2 displayed high degrees of identity to VanRC and VanSC, respectively, and contained the conserved residues identified as important to their function as a response regulator and histidine kinase, respectively. Resistance to vancomycin was expressed inducibly in E. casseliflavus ATCC 25788 and required an extended period of induction. Analysis of peptidoglycan precursors revealed that UDP-N-acetylmuramyl-l-Ala-δ-d-Glu-l-Lys-d-Ala-d-Ser could not be detected until several hours after the addition of vancomycin, and its appearance coincided with the resumption of growth. The introduction of additional copies of the vanTC-2 gene, encoding a putative serine racemase, and the presence of supplementary d-serine in the growth medium both significantly reduced the period before growth resumed after addition of vancomycin. This suggested that the availability of d-serine plays an important role in the induction process. PMID:12234834

  12. Characterisation of the selective binding of antibiotics vancomycin and teicoplanin by the VanS receptor regulating type A vancomycin resistance in the enterococci.

    PubMed

    Hughes, C S; Longo, E; Phillips-Jones, M K; Hussain, R

    2017-08-01

    A-type resistance towards "last-line" glycopeptide antibiotic vancomycin in the leading hospital acquired infectious agent, the enterococci, is the most common in the UK. Resistance is regulated by the VanR A S A two-component system, comprising the histidine sensor kinase VanS A and the partner response regulator VanR A . The nature of the activating ligand for VanS A has not been identified, therefore this work sought to identify and characterise ligand(s) for VanS A . In vitro approaches were used to screen the structural and activity effects of a range of potential ligands with purified VanS A protein. Of the screened ligands (glycopeptide antibiotics vancomycin and teicoplanin, and peptidoglycan components N-acetylmuramic acid, D-Ala-D-Ala and Ala-D-y-Glu-Lys-D-Ala-D-Ala) only glycopeptide antibiotics vancomycin and teicoplanin were found to bind VanS A with different affinities (vancomycin 70μM; teicoplanin 30 and 170μM), and were proposed to bind via exposed aromatic residues tryptophan and tyrosine. Furthermore, binding of the antibiotics induced quicker, longer-lived phosphorylation states for VanS A , proposing them as activators of type A vancomycin resistance in the enterococci. Copyright © 2017 Diamond Light Source Ltd. Published by Elsevier B.V. All rights reserved.

  13. ARC-2009-ACD09-0049-174

    NASA Image and Video Library

    2009-03-14

    FIRST Robotics Competition 'Lunacy' hosted by NASA at San Jose State University Event Center. For Inspiration and Recognition of Science and Technology let the games begin. with Mark Leon, Ames Research Robotics Alliance Project Lead encourages the Ames Space Cookies team #1868

  14. Defense.gov Special Report: Travals with Panetta - April 2012

    Science.gov Websites

    Panetta Visits War College, Marine Base, WWII Memorial in Brazil Panetta Visits Leaders in Brazil Panetta War II Memorial Remarks to the Superior War College by U.S. Defense Secretary Leon E. Panetta, Rio de

  15. EDJJ Notes. Volume 3, Number 3

    ERIC Educational Resources Information Center

    Gagnon, Joe, Ed.

    2004-01-01

    This issue of "EDJJ Notes" contains the following articles: (1) "In the News: Suspension, Race, and Disability in Maryland" (Michael Krezmien and Peter Leone); (2) "Establishing and Maintaining Quality Education Programs in Juvenile Corrections" (Lucky Mason); (3) "Resources for Parents: The Technical Assistance…

  16. NOAA Photo Library - Meet the Photographers/Edward "Budd" Christman

    Science.gov Websites

    NOAA's Office of Budget and Finance; in 1992, he received a Department of Commerce Fellowship and was assigned to the staff of Congressman Leon Panetta, then Chairman of the House Budget Committee. He earned a

  17. Military tropical medicine.

    PubMed

    Bailey, M S; Ellis, C J

    2009-03-01

    Tropical diseases remain a significant threat to deployed military personnel as demonstrated by recent outbreaks amongst troops in Sierra Leone, Iraq and Afghanistan. Five cases are presented from military deployments in tropical or sub-tropical areas, which illustrate important diseases and diagnostic principles for military physicians.

  18. Interior view, attorney general's conference room (the oil painting in ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Interior view, attorney general's conference room (the oil painting in the lunette was done by Leon Kroll and is entitled "Justice Triumphant") - United States Department of Justice, Constitution Avenue between Ninth & Tenth Streets, Northwest, Washington, District of Columbia, DC

  19. Defense.gov Special Report: Travels with Panetta - December 2012

    Science.gov Websites

    Order to Deploy 400 U.S. Personnel to Turkey Defense Secretary Leon E. Panetta has signed an order that will deploy 400 U.S. personnel to Turkey to support the deployment of Patriot missile capability there

  20. Laredo District Coahuila/Nuevo Leon/Tamaulipas border master plan : executive summary.

    DOT National Transportation Integrated Search

    2012-06-01

    Border Master Plans, as defined and supported by the U.S./Mexico Joint Working : Committee on Transportation Planning and Programming, the Federal Highway Administration, : and the U.S. Department of State, are comprehensive long range plans to inven...

  1. ARC-2009-ACD09-0054-005

    NASA Image and Video Library

    2009-04-09

    Yuri's Night 2009 held at the California Acaemy of Sciences in San Francisco, California from left in blue NASA jacket Mark Leon, Pete Worden, Lew Braxton, and Dana Bolles of Ames look over the the NASA Ames robotics team the Cheesy Poofs robot)

  2. Tactile acuity in experienced Tai Chi practitioners: evidence for use dependent plasticity as an effect of sensory-attentional training

    PubMed Central

    Kerr, Catherine E.; Shaw, Jessica R; Wasserman, Rachel H.; Chen, Vanessa W; Kanojia, Alok; Bayer, Thomas; Kelley, John M.

    2008-01-01

    The scientific discovery of novel training paradigms has yielded better understanding of basic mechanisms underlying cortical plasticity, learning and development. This study is a first step in evaluating Tai Chi (TC), the Chinese slow-motion meditative exercise, as a training paradigm that, while not engaging in direct tactile stimulus training, elicits enhanced tactile acuity in long-term practitioners, The rationale for this study comes from the fact that, unlike previously studied direct-touch tactile training paradigms, TC practitioners focus specific mental attention on the body’s extremities including the fingertips and hands as they perform their slow routine. To determine whether TC is associated with enhanced tactile acuity, experienced adult TC practitioners were recruited and compared to age-gender matched controls. A blinded assessor used a validated method (Van Boven, Hamilton, Kauffman, Keenan, & Pascual-Leone, 2000) to compare TC practitioners’ and controls’ ability to discriminate between two different orientations (parallel and horizontal) across different grating widths at the fingertip. Study results showed TC practitioners’ tactile spatial acuity was superior to that of the matched controls (p<.04). There was a trend showing TC may have an enhanced effect on older practitioners (p<.066), suggesting TC may slow age related decline in this measure. To the best of our knowledge, this is the first study to evaluate a long-term attentional practice’s effects on a perceptual measure. Longitudinal studies are needed to examine whether TC initiates or is merely correlated with perceptual changes and whether it elicits long-term plasticity in primary sensory cortical maps. Further studies should also assess whether related somatosensory attentional practices (such as Yoga, mindfulness meditation and Qigong) achieve similar effects. PMID:18512052

  3. Members of the Genera Paenibacillus and Rhodococcus Harbor Genes Homologous to Enterococcal Glycopeptide Resistance Genes vanA and vanB

    PubMed Central

    Guardabassi, L.; Christensen, H.; Hasman, H.; Dalsgaard, A.

    2004-01-01

    Genes homologous to enterococcal glycopeptide resistance genes vanA and vanB were found in glycopeptide-resistant Paenibacillus and Rhodococcus strains from soil. The putative d-Ala:d-Lac ligase genes in Paenibacillus thiaminolyticus PT-2B1 and Paenibacillus apiarius PA-B2B were closely related to vanA (92 and 87%) and flanked by genes homologous to vanH and vanX in vanA operons. PMID:15561881

  4. Members of the genera Paenibacillus and Rhodococcus harbor genes homologous to enterococcal glycopeptide resistance genes vanA and vanB.

    PubMed

    Guardabassi, L; Christensen, H; Hasman, H; Dalsgaard, A

    2004-12-01

    Genes homologous to enterococcal glycopeptide resistance genes vanA and vanB were found in glycopeptide-resistant Paenibacillus and Rhodococcus strains from soil. The putative D-Ala:D-Lac ligase genes in Paenibacillus thiaminolyticus PT-2B1 and Paenibacillus apiarius PA-B2B were closely related to vanA (92 and 87%) and flanked by genes homologous to vanH and vanX in vanA operons.

  5. Biochemical and genetic characterization of the vanC-2 vancomycin resistance gene cluster of Enterococcus casseliflavus ATCC 25788.

    PubMed

    Dutta, Ireena; Reynolds, Peter E

    2002-10-01

    The vanC-2 cluster of Enterococcus casseliflavus ATCC 25788 consisted of five genes (vanC-2, vanXY(C-2), vanT(C-2), vanR(C-2), and vanS(C-2)) and shared the same organization as the vanC cluster of E. gallinarum BM4174. The proteins encoded by these genes displayed a high degree of amino acid identity to the proteins encoded within the vanC gene cluster. The putative D,D-dipeptidase-D,D-carboxypeptidase, VanXY(C-2), exhibited 81% amino acid identity to VanXY(C), and VanT(C-2) displayed 65% amino acid identity to the serine racemase, VanT. VanR(C-2) and VanS(C-2) displayed high degrees of identity to VanR(C) and VanS(C), respectively, and contained the conserved residues identified as important to their function as a response regulator and histidine kinase, respectively. Resistance to vancomycin was expressed inducibly in E. casseliflavus ATCC 25788 and required an extended period of induction. Analysis of peptidoglycan precursors revealed that UDP-N-acetylmuramyl-L-Ala-delta-D-Glu-L-Lys-D-Ala-D-Ser could not be detected until several hours after the addition of vancomycin, and its appearance coincided with the resumption of growth. The introduction of additional copies of the vanT(C-2) gene, encoding a putative serine racemase, and the presence of supplementary D-serine in the growth medium both significantly reduced the period before growth resumed after addition of vancomycin. This suggested that the availability of D-serine plays an important role in the induction process.

  6. Incidence of Acute Kidney Injury among Patients Treated with Piperacillin-Tazobactam or Meropenem in Combination with Vancomycin.

    PubMed

    Rutter, W Cliff; Burgess, David S

    2018-07-01

    Acute kidney injury (AKI) increases during empirical antimicrobial therapy with the combination of piperacillin-tazobactam (TZP) and vancomycin (VAN) compared to the number of incidences with monotherapy or the combination of cefepime and VAN. Limited data regarding the impact of meropenem (MEM) combined with VAN exist. This study examined the AKI incidence among patients treated with MEM plus VAN (MEM+VAN) or TZP+VAN. Data were collected from the University of Kentucky Center for Clinical and Translational Science Enterprise Data Trust from September 2007 through October 2015. Adults without previous renal disease who received MEM+VAN or TZP+VAN for at least 2 days were included. AKI was assessed using risk, injury, failure, loss, and end-stage (RIFLE) criteria. Inverse probability of treatment weighting was utilized to control for differences between groups. In total, 10,236 patients met inclusion criteria, with 9,898 receiving TZP+VAN and 338 receiving MEM+VAN. AKI occurred in 15.4% of MEM+VAN patients and in 27.4% of TZP+VAN patients ( P < 0.001). TZP+VAN was associated with increased AKI compared to the level with MEM+VAN (odds ratio [OR], 2.53; 95% confidence interval [CI], 1.82 to 3.52), after controlling for confounders. Use of MEM+VAN should be considered an appropriate alternative therapy to TZP+VAN if nephrotoxicity is a major concern. The results of this study demonstrate that judicial use of TZP+VAN for empirical coverage of infection is needed. Copyright © 2018 American Society for Microbiology.

  7. Revision of the subfamily Opiinae (Hymenoptera, Braconidae) from Hunan (China), including thirty-six new species and two new genera

    PubMed Central

    Li, Xi-Ying; van Achterberg, Cornelis; Tan, Ji-Cai

    2013-01-01

    Abstract The species of the subfamily Opiinae (Hymenoptera: Braconidae) from Hunan (Oriental China) are revised and illustrated. Thirty-six new species are described: Apodesmia bruniclypealis Li & van Achterberg, sp. n., Apodesmia melliclypealis Li & van Achterberg, sp. n., Areotetes albiferus Li & van Achterberg, sp. n., Areotetes carinuliferus Li & van Achterberg, sp. n., Areotetes striatiferus Li & van Achterberg, sp. n., Coleopioides diversinotum Li & van Achterberg, sp. n., Coleopioides postpectalis Li & van Achterberg, sp. n., Fopius dorsopiferus Li, van Achterberg & Tan, sp. n., Indiopius chenae Li & van Achterberg, sp. n., Opiognathus aulaciferus Li & van Achterberg, sp. n., Opiognathus brevibasalis Li & van Achterberg, sp. n., Opius crenuliferus Li & van Achterberg, sp. n., Opius malarator Li, van Achterberg & Tan, sp. n., Opius monilipalpis Li & van Achterberg, sp. n., Opius pachymerus Li & van Achterberg, sp. n., Opius songi Li & van Achterberg, sp. n., Opius youi Li & van Achterberg, sp. n., Opius zengi Li & van Achterberg, sp. n., Phaedrotoma acuticlypeata Li & van Achterberg, sp. n., Phaedrotoma angiclypeata Li & van Achterberg, sp. n., Phaedrotoma antenervalis Li & van Achterberg, sp. n., Phaedrotoma depressiclypealis Li & van Achterberg, sp. n., Phaedrotoma flavisoma Li & van Achterberg, sp. n., Phaedrotoma nigrisoma Li & van Achterberg, sp. n., Phaedrotoma protuberator Li & van Achterberg, sp. n., Phaedrotoma rugulifera Li & van Achterberg, sp. n., Li & van Achterberg,Phaedrotoma striatinota Li & van Achterberg, sp. n., Phaedrotoma vermiculifera Li & van Achterberg, sp. n., Rhogadopsis latipennis Li & van Achterberg, sp. n., Rhogadopsis longicaudifera Li & van Achterberg, sp. n., Rhogadopsis maculosa Li, van Achterberg & Tan, sp. n., Rhogadopsis obliqua Li & van Achterberg, sp. n., Rhogadopsis sculpturator Li & van Achterberg, sp. n., Utetes longicarinatus Li & van Achterberg, sp. n. and Xynobius notauliferus Li & van Achterberg, sp. n. Areotetes van Achterberg & Li, gen. n. (type species: Areotetes carinuliferus sp. n.) and Coleopioides van Achterberg & Li, gen. n. (type species: Coleopioides postpectalis sp. n. are described. All species are illustrated and keyed. In total 30 species of Opiinae are sequenced and the cladograms are presented. Neopius Gahan, 1917, Opiognathus Fischer, 1972, Opiostomus Fischer, 1972, and Rhogadopsis Brèthes, 1913, are treated as a valid genera based on molecular and morphological differences. Opius vittata Chen & Weng, 2005 (not Opius vittatus Ruschka, 1915), Opius ambiguus Weng & Chen, 2005 (not Wesmael, 1835) and Opius mitis Chen & Weng, 2005 (not Fischer, 1963) are primary homonymsandarerenamed into Phaedrotoma depressa Li & van Achterberg, nom. n., Opius cheni Li & van Achterberg, nom. n. andOpius wengi Li & van Achterberg, nom. n., respectively. Phaedrotoma terga (Chen & Weng, 2005) comb. n.,Diachasmimorpha longicaudata (Ashmead, 1905) and Biosteres pavitita Chen & Weng, 2005, are reported new for Hunan, Opiostomus aureliae (Fischer, 1957) comb. n. is new for China and Hunan; Xynobius maculipennis(Enderlein, 1912) comb. n. is new for Hunan and continental China and Rhogadopsis longuria (Chen & Weng, 2005) comb. n. is new for Hunan. The following new combinations are given: Apodesmia puncta (Weng & Chen, 2005) comb. n., Apodesmia tracta (Weng & Chen, 2005) comb. n., Areotetes laevigatus (Weng & Chen, 2005) comb. n., Phaedrotoma dimidia (Chen & Weng, 2005) comb. n., Phaedrotoma improcera (Weng & Chen, 2005) comb. n., Phaedrotoma amputata (Weng & Chen, 2005) comb. n., Phaedrotoma larga (Weng & Chen, 2005) comb. n., Phaedrotoma osculas (Weng & Chen, 2005) comb. n., Phaedrotoma postuma (Chen & Weng, 2005) comb. n., Phaedrotoma rugulosa (Chen & Weng, 2005) comb. n., Phaedrotoma tabularis (Weng & Chen, 2005) comb. n., Rhogadopsis apii (Chen & Weng, 2005) comb. n., Rhogadopsis dimidia (Chen & Weng, 2005) comb. n., Rhogadopsis diutia (Chen & Weng, 2005) comb. n., Rhogadopsis longuria (Chen & Weng, 2005) comb. n., Rhogadopsis pratellae(Weng & Chen, 2005) comb. n., Rhogadopsis pratensis (Weng & Chen, 2005) comb. n., Rhogadopsis sculpta (Chen & Weng, 2005) comb. n., Rhogadopsis sulcifer (Fischer, 1975) comb. n., Rhogadopsis tabidula(Weng & Chen, 2005) comb. n., Xynobius complexus (Weng & Chen, 2005) comb. n., Xynobius indagatrix (Weng & Chen, 2005) comb. n., Xynobius multiarculatus (Chen & Weng, 2005) comb. n. The following (sub)genera are synonymised: Snoflakopius Fischer, 1972, Jucundopius Fischer, 1984, Opiotenes Fischer, 1998, and Oetztalotenes Fischer, 1998, with Opiostomus Fischer, 1971; Xynobiotenes Fischer, 1998, with Xynobius Foerster, 1862; Allotypus Foerster, 1862, Lemnaphilopius Fischer, 1972, Agnopius Fischer, 1982, and Cryptognathopius Fischer, 1984, with Apodesmia Foerster, 1862; Nosopoea Foerster, 1862, Tolbia Cameron, 1907, Brachycentrus Szépligeti, 1907, Baeocentrum Schulz, 1911, Hexaulax Cameron, 1910, Coeloreuteus Roman, 1910, Neodiospilus Szépligeti, 1911, Euopius Fischer, 1967, Gerius Fischer, 1972, Grimnirus Fischer, 1972, Hoenirus Fischer, 1972, Mimirus Fischer, 1972, Gastrosema Fischer, 1972, Merotrachys Fischer, 1972, Phlebosema Fischer, 1972, Neoephedrus Samanta, Tamili, Saha & Raychaudhuri, 1983, Adontopius Fischer, 1984, Kainopaeopius Fischer, 1986, Millenniopius Fischer, 1996, and Neotropopius Fischer, 1999, with Phaedrotoma Foerster, 1862. PMID:23653521

  8. Scatterometry

    NASA Astrophysics Data System (ADS)

    Stoffelen, Adrianus Cornelis Maria

    1996-10-01

    Een veelheid aan meteorologische metingen is dagelijks beschikbaar. De meeste van deze waarnemingen bevinden zich echter boven land, en met name windwaarnemingen boven de (Noord Atlantische) oceaan zijn schaars. Bij een westelijke luchtstroming is dit een duidelijke beperking voor de weers- en golfverwachtingen ten behoeve van Nederland. Juist dan is het gevaar voor bijvoorbeeld storm of overstroming het grootst. Ook in het aardse klimaatsysteem speelt de wind aan het oppervlak een grote rol en is de belangrijkste factor voor de aandrijving van de oceaancirculatie. De oceaancirculatie op zijn beurt is cruciaal voor de verschijnselen die samenhangen met bijvoorbeeld El Niño. Dit proefschift gaat over het scatterometer instrument dat vanuit de ruimte, zelfs onder een wolkendek, nauwkeurige en betrouwbare informatie geeft over de wind aan het oceaanoppervlak met een hoge mate van ruimtelijke consistentie. Tijdens de tweede wereldoorlog werden radars aan boord van schepen veelvuldig gebruikt voor de opsporing van vijandige vaartuigen. Hierbij werd vastgesteld dat de detectie slechter werd naarmate de wind aan het zeeoppervlak groter was. Proefondervindelijk was hiermee het principe van een wind scatterometer aangetoond. Al snel ontwikkelde zich dan ook de idee de wind aan het zeeoppervlak te meten met behulp van radar. Vanuit een vliegtuig of een satelliet word dan een microgolfbundel onder een schuine hoek naar het zeeoppervlak gestuurd. De microgolfstraling, met gewoonlijk een golflengte van enkele centimeters, wordt verstrooid aan het ruwe oppervlak, en een klein gedeelte van de uitgezonden puls keert terug naar het detectorgedeelte van de scatterometer. Het fysische fenomeen van belang voor de werking van de scatterometer is de aanwezigheid van zogeheten capillaire gavitatiegolven op het zeeoppervlak. Deze golven hebben een golflengte van enkele centimeters en reageren vrijwel instantaan op de sterkte van de wind. De verstrooiing van microgolven is op zijn beurt weer sterk afhankelijk van de amplitude van de capillaire golven. Bovendien blijken de capillaire golfjes over het algemeen gericht in lijn met de windrichting. Aldus bestaat er een verband tussen de hoeveelheid teruggestrooide energie en de windsterkte en -richting op enige hoogte. Een scatterometer instrument wordt zo ontworpen dat uit diverse metingen van het teruggestrooide vermogen, windsterkte en -richting afgeleid kunnen worden. Deze metingen kunnen dan eenvoudig vergeleken worden met bestaande windgegevens van boeien, schepen en weermodellen ter calibratie en validatie.?SAMENVATTING viii Overzicht In de loop der jaren zijn scatterometer instrumenten aan boord van verscheidene satellieten gelanceerd. De scatterometers op de ERS-1 en ERS-2 ("European Remote-sensing Satellite") hebben de langste staat van dienst en zijn sinds 1991 operationeel. Deze scatterometers (die identiek zijn) hebben ieder drie antennes, waarmee het oceaanoppervlak in drie verschillende richtingen bemeten wordt. Een punt op het aardoppervlak wordt eerst door de naar voren gerichte bundel belicht, dan door de naar opzij gerichte bundel, en als laatste door de naar achteren gerichte bundel. De drie metingen, verder kortweg aangeduid als trits, kunnen tegen elkaar worden uitgezet, hetgeen resulteert in een ruimtelijk (3D) plaatje. Door uitgekiende doorsneden te maken van deze ruimte kan de samenhang van de drie metingen kwalitatief worden bestudeerd. De drie metingen blijken dan inderdaad een sterke samenhang te vertonen die verklaard kan worden uit twee geofysische parameters. De drie metingen liggen namelijk in het algemeen dichtbij een hoornvormig (2D) oppervlak. De lengterichting van de hoorn blijkt voornamelijk te corresponderen met een variërende windsterkte (of ruwheid van de zee), en de kortste omtrek van de hoorn met een variërende windrichting (ofwel oriëntatie van de capillaire golfjes). De karakterisatie en modellering van dit oppervlak heeft geleid tot een aanzienlijke verbetering in de interpretatie van de scatterometer, zoals beschreven is in dit proefschrift. Hierboven is een uiterst simplistisch beeld gegeven van de fysica die van belang is bij de interpretatie van de scatterometer. Het eerste hoofdstuk van dit proefschrift beschrijft in meer detail de fysische modellering van belang bij de interpretatie van de scatterometer metingen. Ten eerste, de topografie van het zeeoppervlak is uitermate gecompliceerd en niet nauwkeurig te beschrijven met eenvoudige mathematische vergelijkingen. De capillaire golven hebben een andere fasesnelheid dan de langere golven en beide hebben hiermee een ingewikkelde dynamische interactie. Bij hogere windsnelheid breken de golven en ontstaan er schuimkoppen, hetgeen de fysische beschrijving verder compliceert. Ten tweede, de interactie van een schuin invallende microgolfbundel met dit gecompliceerde oppervlak is evenmin nauwkeurig te beschrijven. Zowel verstrooiing als reflectie kunnen een rol spelen. Ten derde, over de relatie tussen de amplitude van de capillaire golven en de wind op enige hoogte, laten we veronderstellen 10 m, is in de literatuur niet de overeenstemming tot in het gewenste detail. Bij lage windsnelheid zouden de oppervlaktespanning of variaties in de wind variabiliteit een rol kunnen spelen. Gezien de fysische complexiteit, is het niet verwonderlijk dat voor de interpretatie van scatterometer metingen statistische methoden hun opgang gevonden hebben. Dit proefschrift gaat met name in op deze methoden, en geeft, aan de hand van vijf wetenschappelijke publicaties, een tamelijk volledig beeld van de "state-of-the-art", zoals die bereikt is met de?SAMENVATTING ix ERS scatterometers (ERS-1 vanaf 17 juli 1991 en later ERS-2 vanaf 22 november 1995). Het derde hoofdstuk behandelt de visualisatie van de gemeten tritsen in de 3D meetruimte, de bepaling van de spreiding van de metingen rond het hoornvormige oppervlak, en de schatting van de meest waarschijnlijke "werkelijke" (of ruisvrije) trits bij het hoornvormige oppervlak gegeven de metingen en hun nauwkeurigheid (inversie). De perceptie dat de metingen met grote waarschijnlijkheid dichtbij een hoornvormig oppervlak liggen, vormt essentiële a priori informatie van belang voor de inversie. Een inversieprocedure gestoeld op waarschijnlijkheidstheorie is afgeleid. Verder worden aan de hand van de structuur van het hoornvormige oppervlak indicatoren bepaald, van belang voor de kwaliteitscontrole, instrumentbewaking, en de verdere verwerking van de gegevens. In de appendix wordt een methode besproken die beschrijft hoe, aan de hand van geselecteerde windgegevens en een goed wind-microgolf verband, ofwel transfer functie, de scatterometer verstrooiingsmetingen gecalibreerd kunnen worden boven de oceaan. Het blijkt dat deze calibratie, die per antenne wordt uitgevoerd, uiterst nauwkeurig is, en, wanneer toegepast, in de 3D meetruimte de verdeling van gemeten tritsen gemiddeld dichterbij de door de transfer functie gemodelleerde hoorn brengt. Dit levert een verbetert scatterometer wind product op. De methode was met name van groot belang voor de validatie en calibratie van de ERS-2 scatterometer, voordat de instrumentele calibratie was voltooid. Met behulp van een set windgegevens uit een weermodel en hun geschatte nauwkeurigheden, passend in locatie en tijd bij een set van scatterometer metingen en hun geschatte nauwkeurigheden, kan met quasi-lineaire schattingstheorie ("Maximum Likelihood Estimation") de meest waarschijnlijke wind-microgolf transfer functie worden afgeleid. De niet-lineariteit en onnauwkeurige formulering van de transfer functie, een niet-uniforme verdeling van invoergegevens, en een inaccurate formulering van de geschatte nauwkeurigheid kunnen hier een goed resultaat in de weg staan. Een nieuwe functie, genoemd CMOD4, wordt afgeleid in hoofdstuk IV. Een eerste eis die gesteld wordt aan een transfer functie, is dat het in de 3D meetruimte nauwkeurig bij de gemeten tritsen past. Wanneer de "fit" optimaal is zal het gecombineerde effect van meetonnauwkeurigheid en inversiefout kleiner zijn dan 0.5 m s -1 in de wind vector. CMOD4 blijkt binnen deze fout bij de metingen te passen. Een tweede eis is, dat voor een onafhankelijke gegevensset, het verschil tussen de geïnverteerde scatterometer wind en de bijpassende wind van bijvoorbeeld een weermodel zo klein mogelijk is. In de praktijk blijkt dat deze tweede eis impliciet volgt uit de eerste, maar ook dat de onnauwkeurigheid van de scatterometer wind met name wordt bepaald door de associatie van een locatie op de hoorn met een wind vector. De onnauwkeurigheid in de scatterometer wind kan dan ook goed beschreven worden in het wind domein.?SAMENVATTING x In hoofdstuk V wordt dit laatste verder uitgewerkt, en wordt gestreefd naar een gedetailleerde wind calibratie met behulp van in situ gegevens. Windgegevens bevatten doorgaans een relatief grote onnauwkeurigheid. Het wordt aangetoond dat ijking of regressie van zulke gegevens niet mogelijk is in een vergelijking van twee meetsystemen, tenzij de nauwkeurigheid van één van de twee meetsystemen bekend is. In de praktijk is dit meestal niet zo. Voor deze gevallen wordt een methode voorgesteld die uitgaat van de simultane vergelijking van drie meetsystemen. In dit geval kan zowel de ijking als een foutenmodel voor de drie meetsystemen worden opgelost. Toepassing van de methode laat zien dat de scatterometer wind afgeleid met behulp van CMOD4 ruwweg 5 % te laag is, en de oppervlaktewind van het gebruikte weermodel ongeveer 5 % te hoog. Het hoornvormige oppervlak blijkt te bestaan uit twee nauw samenvallende laagjes. Wanneer de wind een component heeft in de kijkrichting van de middelste microgolfbundel wordt de ene hoorn beschreven, en wanneer de wind een component heeft tegengesteld hieraan, de andere. Uit een trits metingen (met ruis) kan dus in het algemeen niet een unieke windvector worden bepaald. Twee ongeveer tegengestelde oplossingen resulteren. Deze dubbelzinnigheid in de windrichting kan in de praktijk worden opgelost door die oplossing te kiezen die het dichtst bij een korte termijn weervoorspelling ligt. Daarna kunnen eisen worden gesteld aan de ruimtelijke consistentie van het gevonden windvector veld. Zoals beschreven in hoofdstuk V levert zo'n methode de goede oplossing in meer dan 99 % van de gevallen. Zo kan een in het algemeen kwalitatief goed windproduct worden afgeleid uit de ERS scatterometermetingen. In het tweede gedeelte van hoofdstuk V wordt ingegaan op de assimilatie van scatterometergegevens in weermodellen. Voor variationele gegevensassimilatie wordt een methode voorgesteld, waarbij de dubbelzinnige scatterometerwinden worden geassimileerd, en niet direct de terugstrooiingsmetingen. Dit vanwege het feit dat de onzekerheid in de interpretatie van de scatterometer, het best is uit te drukken als een fout in de wind. De projectie van deze fout op de microgolfmetingen is niet-lineair, en daarmee tamelijk moeilijk te verwerken binnen de context van meteorologische variationele gegevensassimilatie. Assimilatie van de dubbelzinnige wind daarentegen is tamelijk recht toe recht aan. De scatterometermetingen leiden tot een duidelijk betere analyse en korte-termijn voorspelling van het windveld boven zee. De bedekking is echter zodanig dat andere windwaarnemingen nog lang een zeer welkome aanvulling zullen zijn. Nieuwe Amerikaanse scatterometers met een grotere bedekking zijn in ontwikkeling (met name QuikSCAT en SeaWinds). Vanwege hun andere geometrie en golflengte is echter eerst ontwikkelwerk nodig om tot een gedegen interpretatie te komen. De in dit proefschrift beschreven methodologie kan een belangrijke rol spelen in de interpretatie van de gegevens van deze scatterometers. De volgende generatie Europese scatterometers (ASCAT genoemd) heeft een?SAMENVATTING xi grote bedekking en de microgolflengte en meetgeometrie van de ERS scatterometers. Hiermee zijn we op termijn verzekerd van een goed scatterometer wind product.?SAMENVATTING xii

  9. A revision of the tribe Planitorini van Achterberg (Hymenoptera, Braconidae, Euphorinae), with description of a new genus from Australia.

    PubMed

    van Achterberg, Cornelis; Quicke, Donald L J; Boring, C Andrew

    2017-01-01

    The tribe Planitorini van Achterberg (Hymenoptera: Braconidae: Euphorinae) is revised. One new genus Paramannokeraia gen. n. (type species: P. gibsoni sp. n. ) and five new species from Australia are described and illustrated: Mannokeraia albipalpis van Achterberg, sp. n. , M. nigrita van Achterberg, sp. n. , M. punctata van Achterberg, sp. n. , Paramannokeraia gibsoni van Achterberg & Quicke, sp. n. and P. juliae van Achterberg, sp. n. The tribe Mannokeraiini van Achterberg, 1995, is synonymized with the tribe Planitorini ( syn. n. ).

  10. A revision of the tribe Planitorini van Achterberg (Hymenoptera, Braconidae, Euphorinae), with description of a new genus from Australia

    PubMed Central

    van Achterberg, Cornelis; Quicke, Donald L.J.; Boring, C. Andrew

    2017-01-01

    Abstract The tribe Planitorini van Achterberg (Hymenoptera: Braconidae: Euphorinae) is revised. One new genus Paramannokeraia gen. n. (type species: P. gibsoni sp. n.) and five new species from Australia are described and illustrated: Mannokeraia albipalpis van Achterberg, sp. n., M. nigrita van Achterberg, sp. n., M. punctata van Achterberg, sp. n., Paramannokeraia gibsoni van Achterberg & Quicke, sp. n. and P. juliae van Achterberg, sp. n. The tribe Mannokeraiini van Achterberg, 1995, is synonymized with the tribe Planitorini (syn. n.). PMID:29290713

  11. Consequences of the Introduction of Insensitive Munitions on Safety, Collateral Damage and Operations (consequenties van de invoering van mkm-munitie op veiligheid, gevolgschade en (internationaal) opereren

    DTIC Science & Technology

    2006-06-01

    van de werkzaamheden In dit rapport worden de gevolgen van initiatie van munitie door een ongewilde externe stimulus beschouwd aan de hand van reele...operationele scenario’s. Dit wordt vergeleken met de gevolgen in dezelfde scenario’s, waarin gebruik is gemaakt van Minder Kwetsbare Munitie (MKM). Naast...de historie van MKM wordt uitgelegd wat Inleiding of terroristische activiteiten, maar ook door MKM is. Vervolgens worden de gevolgen Munitie en de

  12. Genomic and expression analysis of the vanG-like gene cluster of Clostridium difficile.

    PubMed

    Peltier, Johann; Courtin, Pascal; El Meouche, Imane; Catel-Ferreira, Manuella; Chapot-Chartier, Marie-Pierre; Lemée, Ludovic; Pons, Jean-Louis

    2013-07-01

    Primary antibiotic treatment of Clostridium difficile intestinal diseases requires metronidazole or vancomycin therapy. A cluster of genes homologous to enterococcal glycopeptides resistance vanG genes was found in the genome of C. difficile 630, although this strain remains sensitive to vancomycin. This vanG-like gene cluster was found to consist of five ORFs: the regulatory region consisting of vanR and vanS and the effector region consisting of vanG, vanXY and vanT. We found that 57 out of 83 C. difficile strains, representative of the main lineages of the species, harbour this vanG-like cluster. The cluster is expressed as an operon and, when present, is found at the same genomic location in all strains. The vanG, vanXY and vanT homologues in C. difficile 630 are co-transcribed and expressed to a low level throughout the growth phases in the absence of vancomycin. Conversely, the expression of these genes is strongly induced in the presence of subinhibitory concentrations of vancomycin, indicating that the vanG-like operon is functional at the transcriptional level in C. difficile. Hydrophilic interaction liquid chromatography (HILIC-HPLC) and MS analysis of cytoplasmic peptidoglycan precursors of C. difficile 630 grown without vancomycin revealed the exclusive presence of a UDP-MurNAc-pentapeptide with an alanine at the C terminus. UDP-MurNAc-pentapeptide [d-Ala] was also the only peptidoglycan precursor detected in C. difficile grown in the presence of vancomycin, corroborating the lack of vancomycin resistance. Peptidoglycan structures of a vanG-like mutant strain and of a strain lacking the vanG-like cluster did not differ from the C. difficile 630 strain, indicating that the vanG-like cluster also has no impact on cell-wall composition.

  13. Development Communication Report. No. 46, Summer 1984.

    ERIC Educational Resources Information Center

    Development Communication Report, 1984

    1984-01-01

    A variety of articles address the use of communications in development, including (1) "Policy Considerations in Global Telecommunications" (Sandra Lauffer); (2) "Sharing Information for Rehabilitation in the Third World" (M. Miles); (3) "Growing More Rice in Sierra Leone: Baseline Survey Guides Media Campaign" (Gary…

  14. Evolving Service Poles in Presence Missions.

    DTIC Science & Technology

    1995-08-01

    were trained, equipped, deployed and re-deployed t-.hrough FMF; e.g., Morocco in Somalia and S*n* ga , Nigeria, Ghana, Siarra Leone. Uganda, and TanzarH...Mongolia, Nopal , and Bangladesh, military outraach programs, including parsonnsl exchanges and multinational conferences, provide some of our basic

  15. Differential diagnosis of illness in travelers arriving from Sierra Leone, Liberia, or Guinea: a cross-sectional study from the GeoSentinel Surveillance Network.

    PubMed

    Boggild, Andrea K; Esposito, Douglas H; Kozarsky, Phyllis E; Ansdell, Vernon; Beeching, Nicholas J; Campion, Daniel; Castelli, Francesco; Caumes, Eric; Chappuis, Francois; Cramer, Jakob P; Gkrania-Klotsas, Effrossyni; Grobusch, Martin P; Hagmann, Stefan H F; Hynes, Noreen A; Lim, Poh Lian; López-Vélez, Rogelio; Malvy, Denis J M; Mendelson, Marc; Parola, Philippe; Sotir, Mark J; Wu, Henry M; Hamer, Davidson H

    2015-06-02

    The largest-ever outbreak of Ebola virus disease (EVD), ongoing in West Africa since late 2013, has led to export of cases to Europe and North America. Clinicians encountering ill travelers arriving from countries with widespread Ebola virus transmission must be aware of alternate diagnoses associated with fever and other nonspecific symptoms. To define the spectrum of illness observed in persons returning from areas of West Africa where EVD transmission has been widespread. Descriptive, using GeoSentinel records. 57 travel or tropical medicine clinics in 25 countries. 805 ill returned travelers and new immigrants from Sierra Leone, Liberia, or Guinea seen between September 2009 and August 2014. Frequencies of demographic and travel-related characteristics and illnesses reported. The most common specific diagnosis among 770 nonimmigrant travelers was malaria (n = 310 [40.3%]), with Plasmodium falciparum or severe malaria in 267 (86%) and non-P. falciparum malaria in 43 (14%). Acute diarrhea was the second most common diagnosis among nonimmigrant travelers (n = 95 [12.3%]). Such common diagnoses as upper respiratory tract infection, urinary tract infection, and influenza-like illness occurred in only 26, 9, and 7 returning travelers, respectively. Few instances of typhoid fever (n = 8), acute HIV infection (n = 5), and dengue (n = 2) were encountered. Surveillance data collected by specialist clinics may not be representative of all ill returned travelers. Although EVD may currently drive clinical evaluation of ill travelers arriving from Sierra Leone, Liberia, and Guinea, clinicians must be aware of other more common, potentially fatal diseases. Malaria remains a common diagnosis among travelers seen at GeoSentinel sites. Prompt exclusion of malaria and other life-threatening conditions is critical to limiting morbidity and mortality. Centers for Disease Control and Prevention.

  16. Determinants of Utilization and Community Experiences with Community Health Volunteers for Treatment of Childhood Illnesses in Rural Sierra Leone.

    PubMed

    Yansaneh, Aisha I; George, Asha S; Sharkey, Alyssa; Brieger, William R; Moulton, Lawrence H; Yumkella, Fatu; Bangura, Peter; Kabano, Augustin; Diaz, Theresa

    2016-04-01

    In 2010, at the same time as the national roll out of the Free Health Care Initiative (FHCI), which removed user fees for facility based health care, trained community health volunteers (CHVs) were deployed to provide integrated community case management of diarrhea, malaria and pneumonia to children under 5 years of age (U5) in Kambia and Pujehun districts, Sierra Leone. After 2 years of implementation and in the context of FHCI, CHV utilization rate was 14.0 %. In this study, we examine the factors associated with this level of CHV utilization. A cross-sectional household-cluster survey of 1590 caregivers of 2279 children U5 was conducted in 2012; with CHV utilization assessed using a multiple logistic regression model. Focus groups and in-depth interviews were also conducted to understand communities' experiences with CHVs. Children with diarrhea (OR = 3.17, 95 % CI: 1.17-8.60), from female-headed households (OR = 4.55, 95 % CI: 1.88-11.00), and whose caregivers reported poor quality of care as a barrier to facility care-seeking (OR = 8.53, 95 % CI: 3.13-23.16) were more likely to receive treatment from a CHV. Despite low utilization, caregivers were highly familiar and appreciative of CHVs, but were concerned about the lack of financial remuneration for CHVs. CHVs remained an important source of care for children from female-headed households and whose caregivers reported poor quality of care at health facilities. CHVs are an important strategy for certain populations even when facility utilization is high or when facility services are compromised, as has happened with the recent Ebola epidemic in Sierra Leone.

  17. An assessment of the impacts of pesticide use on the environment and health of rice farmers in Sierra Leone.

    PubMed

    Sankoh, Alhaji I; Whittle, Rebecca; Semple, Kirk T; Jones, Kevin C; Sweetman, Andrew J

    2016-09-01

    One of the biggest challenges faced by Sierra Leonean farmers is pest control. Birds, rodents, insects, crustaceans and other organisms can drastically reduce yields. In order to prevent these organisms from destroying their crop, farmers use pesticides. However there are reports that these chemicals are being misused and such misuse is having a negative impact on the environment and the health of the farmers. This research study aimed to investigate the use of pesticides in rice fields and its potential effects on the environment and on the farmers of Sierra Leone. Five hundred farmers and one hundred health workers across the country were interviewed. Fifty focus group discussions were also completed. Field observations were also undertaken to see how farmers apply pesticides to their farms and the possible threats these methods have on human health and the environment. It is clear that a wide range of pesticides are used by rice farmers in Sierra Leone with 60% of the pesticides used entering the country illegally. Most farmers have no knowledge about the safe handling of pesticides as 71% of them have never received any form of training. The pesticides kill both target and non-target organisms some of which enter the food chain. Cases of health problems such as nausea, respiratory disorders and blurred vision investigated in this research are significantly higher among farmers who use pesticides than those who do not use pesticides. Cases of pesticide intoxication are not investigated by health workers but results obtained from interviews with them also indicated that cases of pesticides related symptoms are significantly higher in environments where pesticides are used than those in which pesticides are not used. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. The role of traditional treatment on health care seeking by caregivers for sick children in Sierra Leone: results of a baseline survey.

    PubMed

    Bakshi, Salina S; McMahon, Shannon; George, Asha; Yumkella, Fatu; Bangura, Peter; Kabano, Augustin; Diaz, Theresa

    2013-07-01

    In Sierra Leone, traditional treatment is at times used in lieu of seeking allopathic healthcare for major illnesses causing child death. This paper describes the nature of traditional treatment for diarrhea and fever (presumed malaria). Weighted analysis and multi-logistic regression was applied to a household cluster survey (n=5951) conducted in 4 districts in June 2010. Using structured questionnaires, heads of households, and caregivers of children under five years of age were interviewed about child morbidity and care seeking. A thematic analysis of qualitative data based on focus group discussions and in-depth interviews with family members from twelve villages in these same four districts, was also done. Illness-specific herbal remedies were described by respondents. Among 1511 children with diarrhea, 31% used traditional treatment. Among 3851 children with fever, 22% used traditional treatment. Traditional treatment for diarrhea was associated with being from a tribe other than the Mende, using government recommended salt sugar solution, not having a vaccine card, having more than two illnesses, and not seeking any allopathic medical treatment for diarrhea. For fever, traditional treatment was associated with being a tribe other than the Mende, having more than two illnesses, not having a vaccine card, Muslim religion, and not seeking any allopathic medical treatment for fever. Qualitatively, respondents describe herbalists as trusted with remedies that are seen to be appropriate due to the perceived cause of illness and due to barriers to seeking care from government providers. The social determinants of traditional treatment use and the prominent role of herbalists in providing them need to be addressed to improve child survival in Sierra Leone. Copyright © 2013 Elsevier B.V. All rights reserved.

  19. Herbal medicine use among hypertensive patients attending public and private health facilities in Freetown Sierra Leone.

    PubMed

    James, Peter Bai; Kamara, Halimatu; Bah, Abdulai Jawo; Steel, Amie; Wardle, Jon

    2018-05-01

    This study aimed to determine the prevalence, determinants and pattern of herbal medicine use among hypertensive patients in Freetown. We conducted a cross-sectional study among hypertensive patients attending public and private health facilities in Freetown, Sierra Leone between August and October 2016. We analyzed the data using SPSS version 24. We used Chi-square, Fisher exact two-tailed test and regression analysis for data analysis. A p-value less than 0.05 was considered statistically significant. Out of 260 study participants, over half (n = 148, 56.9%) reported using herbal medicine for the treatment of hypertension alone or together with comorbid condition(s). The most commonly used herbal medicine among users were honey (n = 89, 33.3%), moringa (n = 80, 30.0%) and garlic (n = 73, 27.3%). No significant difference existed between users and non-users of herbal medicine with regards to socio-demographic and health-related factors. The majority (n = 241, 92.7%) of respondents considered herbal medicine beneficial if it was recommended by a healthcare provider yet 85.1% (n = 126) did not disclose their herbal medicine use to their health care provider. There is a high use of herbal medicines among hypertensive patients in Freetown, Sierra Leone. It is essential for healthcare providers to take heed of the findings of this study and routinely ask their patients about their herbal medicine use status. Such practice will provide the opportunity to discuss the benefits and risks of herbal medicine use with the aim of maximizing patient desired therapeutic outcomes. Copyright © 2018 Elsevier Ltd. All rights reserved.

  20. Persistent Organic Pollutants and Heavy Metal Concentrations in Soil from the Metropolitan Area of Monterrey, Nuevo Leon, Mexico.

    PubMed

    Orta-García, Sandra Teresa; Ochoa-Martinez, Angeles Catalina; Carrizalez-Yáñez, Leticia; Varela-Silva, José Antonio; Pérez-Vázquez, Francisco Javier; Pruneda-Álvarez, Lucia Guadalupe; Torres-Dosal, Arturo; Guzmán-Mar, Jorge Luis; Pérez-Maldonado, Iván N

    2016-04-01

    The purpose of this study was to assess the levels of polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethane (DDE), and four heavy metals (arsenic, cadmium, and lead) in outdoor surface soils (50 samples) collected from the metropolitan area of Monterrey in Mexico. Total PBDEs levels ranged from 1.80 to 127 µg/kg, with mean total PBDEs level of 14.2 ± 21.5 µg/kg (geometric mean ± standard deviation). For PCBs, the mean total level in the studied soils was 23.5 ± 20.2 µg/kg (range 4.0-65.5 µg/kg). An important finding in our study was that all soil samples (100%) had detectable levels of the metabolite p,p'-DDE. Moreover, the mean total DDT level (∑p'p-DDT and p'p-DDE) was approximately 132 ± 175 µg/kg. The mean levels for arsenic, cadmium, and lead in soil were 5.30 ± 1.35 (range 1.55-7.85) mg/kg, 2.20 ± 1.20 (range 0.65-6.40) mg/kg, and 455 ± 204 (range 224-1230) mg/kg, respectively. Our study has several limitations, the most notable of which is the small sample of soils evaluated. However, this screening study provided concentration data for the occurrence of POPs and four heavy metals in soil from the metropolitan area of Monterrey, Nuevo Leon, Mexico, and taking into consideration that soil is an important pathway of exposure for people, a biomonitoring program for the surveillance of the general population in the metropolitan area of Monterrey, Nuevo Leon is deemed necessary.

  1. Microbiological and Chemical Quality of Packaged Sachet Water and Household Stored Drinking Water in Freetown, Sierra Leone

    PubMed Central

    Jalloh, Mohamed F.; Saquee, George; Bain, Robert E. S.; Bartram, Jamie K.

    2015-01-01

    Packaged drinking water (PW) sold in bottles and plastic bags/sachets is widely consumed in low- and middle-income countries (LMICs), and many urban users in sub-Saharan Africa (SSA) rely on packaged sachet water (PSW) as their primary source of water for consumption. However, few rigorous studies have investigated PSW quality in SSA, and none have compared PSW to stored household water for consumption (HWC). A clearer understanding of PSW quality in the context of alternative sources is needed to inform policy and regulation. As elsewhere in SSA, PSW is widely consumed in Sierra Leone, but government oversight is nearly nonexistent. This study examined the microbiological and chemical quality of a representative sample of PSW products in Freetown, Sierra Leone at packaged water manufacturing facilities (PWMFs) and at points of sale (POSs). Samples of HWC were also analyzed for comparison. The study did not find evidence of serious chemical contamination among the parameters studied. However, 19% of 45 PSW products sampled at the PWMF contained detectable Escherichia coli (EC), although only two samples exceeded 10 CFU/100 mL. Concentrations of total coliforms (TC) in PSW (but not EC) increased along the supply chain. Samples of HWC from 60 households in Freetown were significantly more likely to contain EC and TC than PSW at the point of production (p<0.01), and had significantly higher concentrations of both bacterial indicators (p<0.01). These results highlight the need for additional PSW regulation and surveillance, while demonstrating the need to prioritize the safety of HWC. At present, PSW may be the least unsafe option for many households. PMID:26162082

  2. Assessing the impact of mass rape on the incidence of HIV in conflict-affected countries

    PubMed Central

    Virginie, Supervie; Yasmin, Halima; Sally, Blower

    2010-01-01

    Objectives To quantify the potential impact of mass rape on HIV incidence in seven conflict-afflicted-countries (CACs), with severe HIV epidemics, in Sub-Saharan Africa. Design Uncertainty analysis of a risk equation model. Methods A mathematical model was used to evaluate the potential impact of mass rape on increasing HIV incidence in women and girls in: Burundi, Democratic Republic of Congo (DRC), Rwanda, Sierra Leone, Somalia, southern Sudan and Uganda. The model was parameterized with data from UNAIDS/WHO and the US Census Bureau’s International Data Base. Incidence data from UNAIDS/WHO were used for calibration. Results Mass rape could cause ~five HIV infections per 100,000 females per year in the DRC, Sudan, Somalia and Sierra Leone, double that in Burundi and Rwanda, and quadruple that in Uganda. The number of females infected per year due to mass rape is likely to be relatively low in Somalia and Sierra Leone, 127 (median: Inter-Quartile-Range (IQR) 55–254) and 156 (median: IQR 69–305), respectively. Numbers could be high in the DRC and Uganda: 1,120 (median: IQR 527–2,360) and 2,172 (median: IQR 1,031–4,668), respectively. In Burundi, Rwanda and Sudan numbers are likely to be intermediate. Under extreme conditions 10,000 women and girls could be infected per year in the DRC, and 20,000 women and girls in Uganda. Mass rape could increase annual incidence by ~ 7% (median: IQR 3–15). Conclusions Interventions and treatment targeted to rape survivors during armed conflicts could reduce HIV incidence. Support should be provided both on the basis of human rights and public health. PMID:20859191

  3. Changes in Health-Seeking Behavior Did Not Result in Increased All-Cause Mortality During the Ebola Outbreak in Western Area, Sierra Leone.

    PubMed

    Vygen, Sabine; Tiffany, Amanda; Rull, Monica; Ventura, Alexandre; Wolz, Anja; Jambai, Amara; Porten, Klaudia

    2016-10-05

    Little is known about the residual effects of the west African Ebola virus disease (Ebola) epidemic on non-Ebola mortality and health-seeking behavior in Sierra Leone. We conducted a retrospective household survey to estimate mortality and describe health-seeking behavior in Western Area, Sierra Leone, between May 25, 2014, and February 16, 2015. We used two-stage cluster sampling, selected 30 geographical sectors with probability proportional to population size, and sampled 30 households per sector. Survey teams conducted face-to-face interviews and collected information on mortality and health-seeking behavior. We calculated all-cause and Ebola-specific mortality rates and compared health-seeking behavior before and during the Ebola epidemic using χ 2 and Fisher's exact tests. Ninety-six deaths, 39 due to Ebola, were reported in 898 households. All-cause and Ebola-specific mortality rates were 0.52 (95% confidence interval [CI] = 0.29-0.76) and 0.19 (95% CI = 0.01-0.38) per 10,000 inhabitants per day, respectively. Of those households that reported a sick family member during the month before the survey, 86% (73/85) sought care at a health facility before the epidemic, compared with 58% (50/86) in February 2015 (P = 0.013). Reported self-medication increased from 4% (3/85) before the epidemic to 23% (20/86) during the epidemic (P = 0.013). Underutilization of health services and increased self-medication did not show a demonstrable effect on non-Ebola-related mortality. Nevertheless, the residual effects of outbreaks need to be taken into account for the future. Recovery efforts should focus on rebuilding both the formalized health system and the population's trust in it. © The American Society of Tropical Medicine and Hygiene.

  4. A clinical survey on the prevalence and types of cheek teeth disorders present in 400 Zamorano-Leonés and 400 Mirandês donkeys (Equus asinus).

    PubMed

    Rodrigues, J B; Dixon, P M; Bastos, E; San Roman, F; Viegas, C

    2013-12-14

    Dental disease is now recognised as a major but often unrecognised disorder of equids, including horses and donkeys. However, very few large clinical studies have documented the prevalence and type of dental disease present in different equid populations and no dental studies have been reported in Zamorano-Leonés or Mirandês donkeys, two endangered donkey breeds. Clinical and detailed oral examinations were performed in 400 Mirandês and 400 Zamorano-Leonés donkeys in Portugal and Spain. It was found that just 4.5 per cent had ever received any previous dental care. Cheek teeth (CT) disorders were present in 82.8 per cent of these donkeys, ranging from a prevalence of 29.6 per cent in the <2.5-year-old group to 100 per cent in the >25-year-old group. These CT disorders included enamel overgrowths (73.1 per cent prevalence but with just 6.3 per cent having associated soft tissue injuries), focal overgrowths (37.3 per cent), periodontal disease (23.5 per cent) and diastemata (19.9 per cent). Peripheral caries was present in 5.9 per cent of cases, but inexplicably, infundibular caries was very rare (1.3 per cent prevalence); this may have been due to their almost fully foraged diet. The high prevalence of enamel overgrowths in these donkeys, most which never received concentrates, also raises questions about the aetiology of this disorder. This very high prevalence of CT disorders, especially in older donkeys, was of great welfare concern in some cases and emphasises the need for routine dental care in these cases on welfare grounds and in order to help preserve these unique breeds.

  5. Health workers' experiences of coping with the Ebola epidemic in Sierra Leone's health system: a qualitative study.

    PubMed

    Raven, Joanna; Wurie, Haja; Witter, Sophie

    2018-04-05

    The 2014 Ebola Virus Disease epidemic evolved in alarming ways in Sierra Leone spreading to all districts. The country struggled to control it against a backdrop of a health system that was already over-burdened. Health workers play an important role during epidemics but there is limited research on how they cope during health epidemics in fragile states. This paper explores the challenges faced by health workers and their coping strategies during the Ebola outbreak in four districts - Bonthe, Kenema, Koinadugu and Western Area - of Sierra Leone. We used a qualitative study design: key informant interviews (n = 19) with members of the District Health Management Teams and local councils, health facility managers and international partners; and in depth interviews with health workers (n = 25) working in public health facilities and international health workers involved with the treatment of Ebola patients. There were several important coping strategies including those that drew upon existing mechanisms: being sustained by religion, a sense of serving their country and community, and peer and family support. Externally derived strategies included: training which built health worker confidence in providing care; provision of equipment to do their job safely; a social media platform which helped health workers deal with challenges; workshops that provided ways to deal with the stigma associated with being a health worker; and the risk allowance, which motivated staff to work in facilities and provided an additional income source. Supportive supervision, peer support networks and better use of communication technology should be pursued, alongside a programme for rebuilding trusting relations with community structures. The challenge is building these mechanisms into routine systems, pre-empting shocks, rather than waiting to respond belatedly to crises.

  6. Microbiological and Chemical Quality of Packaged Sachet Water and Household Stored Drinking Water in Freetown, Sierra Leone.

    PubMed

    Fisher, Michael B; Williams, Ashley R; Jalloh, Mohamed F; Saquee, George; Bain, Robert E S; Bartram, Jamie K

    2015-01-01

    Packaged drinking water (PW) sold in bottles and plastic bags/sachets is widely consumed in low- and middle-income countries (LMICs), and many urban users in sub-Saharan Africa (SSA) rely on packaged sachet water (PSW) as their primary source of water for consumption. However, few rigorous studies have investigated PSW quality in SSA, and none have compared PSW to stored household water for consumption (HWC). A clearer understanding of PSW quality in the context of alternative sources is needed to inform policy and regulation. As elsewhere in SSA, PSW is widely consumed in Sierra Leone, but government oversight is nearly nonexistent. This study examined the microbiological and chemical quality of a representative sample of PSW products in Freetown, Sierra Leone at packaged water manufacturing facilities (PWMFs) and at points of sale (POSs). Samples of HWC were also analyzed for comparison. The study did not find evidence of serious chemical contamination among the parameters studied. However, 19% of 45 PSW products sampled at the PWMF contained detectable Escherichia coli (EC), although only two samples exceeded 10 CFU/100 mL. Concentrations of total coliforms (TC) in PSW (but not EC) increased along the supply chain. Samples of HWC from 60 households in Freetown were significantly more likely to contain EC and TC than PSW at the point of production (p<0.01), and had significantly higher concentrations of both bacterial indicators (p<0.01). These results highlight the need for additional PSW regulation and surveillance, while demonstrating the need to prioritize the safety of HWC. At present, PSW may be the least unsafe option for many households.

  7. Rapid deployment of a mobile biosafety level-3 laboratory in Sierra Leone during the 2014 Ebola virus epidemic

    PubMed Central

    Zhang, Yi; Gong, Yan; Wang, Chengyu; Liu, Wensen; Wang, Zhongyi; Xia, Zhiping; Bu, Zhaoyang; Lu, Huijun; Sun, Yang; Zhang, Xiaoguang; Cao, Yuxi; Yang, Fan; Su, Haoxiang; Hu, Yi; Deng, Yongqiang; Zhou, Bo; Zhao, Zongzheng; Fu, Yingying; Kargbo, David; Dafae, Foday; Kargbo, Brima; Kanu, Alex; Qian, Jun; Guo, Zhendong

    2017-01-01

    Background Ebola virus emerged in West Africa in December 2013. The high population mobility and poor public health infrastructure in this region led to the development of the largest Ebola virus disease (EVD) outbreak to date. Methodology/Principal findings On September 26, 2014, China dispatched a Mobile Biosafety Level-3 Laboratory (MBSL-3 Lab) and a well-trained diagnostic team to Sierra Leone to assist in EVD diagnosis using quantitative real-time PCR, which allowed the diagnosis of suspected EVD cases in less than 4 hours from the time of sample receiving. This laboratory was composed of three container vehicles equipped with advanced ventilation system, communication system, electricity and gas supply system. We strictly applied multiple safety precautions to reduce exposure risks. Personnel, materials, water and air flow management were the key elements of the biosafety measures in the MBSL-3 Lab. Air samples were regularly collected from the MBSL-3 Lab, but no evidence of Ebola virus infectious aerosols was detected. Potentially contaminated objects were also tested by collecting swabs. On one occasion, a pipette tested positive for EVD. A total of 1,635 suspected EVD cases (824 positive [50.4%]) were tested from September 28 to November 11, 2014, and no member of the diagnostic team was infected with Ebola virus or other pathogens, including Lassa fever. The specimens tested included blood (69.2%) and oral swabs (30.8%) with positivity rates of 54.2% and 41.9%, respectively. The China mobile laboratory was thus instrumental in the EVD outbreak response by providing timely and reliable diagnostics. Conclusions/Significance The MBSL-3 Lab significantly contributed to establishing a suitable laboratory response capacity during the emergence of EVD in Sierra Leone. PMID:28505171

  8. Rapid deployment of a mobile biosafety level-3 laboratory in Sierra Leone during the 2014 Ebola virus epidemic.

    PubMed

    Zhang, Yi; Gong, Yan; Wang, Chengyu; Liu, Wensen; Wang, Zhongyi; Xia, Zhiping; Bu, Zhaoyang; Lu, Huijun; Sun, Yang; Zhang, Xiaoguang; Cao, Yuxi; Yang, Fan; Su, Haoxiang; Hu, Yi; Deng, Yongqiang; Zhou, Bo; Zhao, Zongzheng; Fu, Yingying; Kargbo, David; Dafae, Foday; Kargbo, Brima; Kanu, Alex; Liu, Linna; Qian, Jun; Guo, Zhendong

    2017-05-01

    Ebola virus emerged in West Africa in December 2013. The high population mobility and poor public health infrastructure in this region led to the development of the largest Ebola virus disease (EVD) outbreak to date. On September 26, 2014, China dispatched a Mobile Biosafety Level-3 Laboratory (MBSL-3 Lab) and a well-trained diagnostic team to Sierra Leone to assist in EVD diagnosis using quantitative real-time PCR, which allowed the diagnosis of suspected EVD cases in less than 4 hours from the time of sample receiving. This laboratory was composed of three container vehicles equipped with advanced ventilation system, communication system, electricity and gas supply system. We strictly applied multiple safety precautions to reduce exposure risks. Personnel, materials, water and air flow management were the key elements of the biosafety measures in the MBSL-3 Lab. Air samples were regularly collected from the MBSL-3 Lab, but no evidence of Ebola virus infectious aerosols was detected. Potentially contaminated objects were also tested by collecting swabs. On one occasion, a pipette tested positive for EVD. A total of 1,635 suspected EVD cases (824 positive [50.4%]) were tested from September 28 to November 11, 2014, and no member of the diagnostic team was infected with Ebola virus or other pathogens, including Lassa fever. The specimens tested included blood (69.2%) and oral swabs (30.8%) with positivity rates of 54.2% and 41.9%, respectively. The China mobile laboratory was thus instrumental in the EVD outbreak response by providing timely and reliable diagnostics. The MBSL-3 Lab significantly contributed to establishing a suitable laboratory response capacity during the emergence of EVD in Sierra Leone.

  9. Population education in Sierra Leone.

    PubMed

    Lucan, T A

    1985-06-01

    The 1977 Sierra Leone 3 year population education project had 5 objectives: 1) to develop a core of Sierra Leoneans qualified in population education, 2) to integrate population education concepts into the curriculum for secondary schools and teachers colleges, 3) to train teachers already engaged in trial teaching in pilot schools in the new integrated curricula to give support to their colleagues, 4) to integrate population education into the whole Sierra Leone educational system, and 5) to create an awareness of the implications of population growth on the socioeconomic development of the country. A 1977 seminar on the Social Studies and Population Education Program discussed population issues and economic and social development. The strategy recommended at the seminar was that both the minor and the major revision approaches be used in the integration of population education concepts into the existing curriculum of the National Program in Social Studies for the lower secondary level. A Spiral Curriculum was established in 1981 constructed of 6 topics: 1) man's origins, development, and characteristics; 2) man's environment; 3) man's culture; 4) population and resources; 5) communication in the service of man; and 6) global issues-achievement and problems. Both at in-service and at pre-servicetraining, the enquiry method of teaching was emphasized. By the end of December 1981, the curriculum in Social Studies integrated with Population Education was completed for secondary schools and secondary teachers' colleges. The availability of the textbooks that secondary school students will take to their homes for their parents to read will contribute immensely to the attainment of the development objective of creating an awareness of the implications and consequences of population growth on the socioeconomic development of the country.

  10. Inelastic processes in atomic collisions involving ground state and laser-prepared atoms

    NASA Astrophysics Data System (ADS)

    Planje, Willem Gilles

    1999-11-01

    In dit proefschrift worden experimenten beschreven waarbij ionen of atomen met een bepaalde snelheid op een ensemble van doelwitatomen worden gericht. Wanneer twee deeltjes elkaar voldoende genaderd hebben, vindt er wissel- werking plaats waarbij allerlei processen kunnen optreden. Deze processen resulteren in specieke eindproducten. Kennis over de interactie tussen twee botsingspartners wordt verkregen door te bekijken welke eindproducten ontstaan, en in welke mate. Een belangrijke grootheid die van invloed is op mogelijke processen is de onderlinge snelheid van de twee kernen, oftewel de botsingssnelheid. Wanneer de botsingssnelheid voldoende klein is dan kunnen de verschillende reactiemechanismen zowel kwalitatief als kwanti- tatief vaak goed voorspeld worden door het systeem te beschouwen als een kort-stondig molecuul, opgebouwd uit de twee botsende deeltjes. De ver- schillende processen die kunnen optreden worden gekwaliceerd afhankelijk van de vorming van bepaalde eindproducten. Ruwweg de volgende indeling kan gemaakt worden: 1. de interne structuur van de eindproducten zijn identiek aan die van de beginproducten. We spreken dan van een elastische botsing. 2. e en van de deeltjes of beiden worden in een aangeslagen toestand ge- bracht (of ge¨oniseerd). Dit zijn processen waarbij de herschikte elek- tronen zich bij de oorspronkelijke kern bevinden. We spreken dan van excitatie of ionisatie. 3. e en of meerdere elektronen bevinden zich bij de andere kern na de botsing (eventueel in aangeslagen toestand). We spreken dan van elek- tronenoverdracht. In het eerste deel van deze dissertatie worden botsingsexperimenten tussen heliumionen en natriumatomen beschreven waarbij het proces van elek- tronenoverdracht wordt onderzocht. Bij dit mechanisme is het buitenste 117?Samenvatting natriumelektron betrokken. Deze kan relatief gemakkelijk `overspringen' naar het heliumion wanneer deze zich dicht in de buurt van het natrium- atoom bevindt. Het elektron kan hierbij een bepaalde (aangeslagen) toe- stand bezetten. Wij meten de bezetting van de heliumtoestanden die onder uitzending van XUV licht ( ? 58 nm) vervallen naar de heliumgrondtoe- stand. Door de lichtintensiteit te meten onderzoeken we de mate van elek- tronenoverdracht naar een selecte groep van singlet helium`eind'toestanden, namelijk He(1s2p), He(1s3s), He(1s3p) en He(1s3d). In een reactie- vergelijking ziet het mechanisme er als volgt uit: He + (1s) + ( Na(3s) Na(3p) e- -! He + Na + -! He(1s 2 ) +h(58 nm) + Na + Het experiment kent een extra dimensie door het feit dat het, in beginsel bol- symmetrische, natriumatoom een bepaalde ruimtelijk uitlijning kan worden meegegeven. Met behulp van laserlicht van een specieke frequentie en po- larisatie, wordt het buitenste natriumelektron in een aangeslagen p toestand gebracht. Het aanslaan naar deze toestand heeft als gevolg dat het valentie- elektron zich op grotere afstand van zijn kern bevindt dan voorheen. Daar- naast kan, afhankelijk van de gebruikte laserpolarisatie, het buitenste elek- tron zich nu rond de natriumkern bewegen volgens een bepaalde anisotrope verdeling, de bolsymmetrie is doorbroken. De eecten van de excitatie en ruimtelijk verdeling van dit natriumelektron op het proces van elektronen- overdracht zijn onderzocht voor botsingsenergie¨en vari¨erend van 0.5 keV tot 6.0 keV. De metingen laten zien dat het eect van laserexcitatie een bezettingstoe- name van de beschouwde singlet heliumtoestanden betekent, ongeacht de uitlijning van het natrium 3p elektron. Dit is simpelweg te begrijpen uit het feit dat het 3p natrium elektron minder sterk gebonden is en elektro- nenoverdracht makkelijker gaat. Daarnaast is de uitlijning van het aanges- lagen elektron van invloed op de elektronenoverdracht. De resultaten zijn vergeleken met berekeningen van S.E. Nielsen en T.H. Rod [13], die de elek- tronoverdracht beschrijven in een model waarbij het betrokken elektron zich beweegt in bepaalde eectieve potentiaalvelden. De goede overeenkomsten van onze metingen met de berekeningen rechtvaardigen de theoretische be- nadering van Nielsen en Rod. 118?Samenvatting In het tweede gedeelte van het proefschrift worden botsingen beschouwd tussen helium- en neonatomen. Hierbij wordt nu niet gekeken naar bots- ingsproducten die zich manifesteren door bepaald licht uit te zenden, maar een elektron emitteren met een bepaalde energie. Verschillende soorten `eind'producten kunnen elektronen uitzenden, waaronder de negatieve ion- toestanden. Het elektronenspectrum, gemeten voor dit botsingssysteem, vertoont twee pieken die het spectrum domineren bij 16.2 eV en 19.4 eV voor verschillende botsingsenergie¨en tussen de 0.35 keV en 6.0 keV. Deze piekstructuren wijzen op de vorming van de kort-levende, negatieve iontoe- standen Ne-(2p 5 3s 2 ) en He-(1s2s 2 ) ten gevolge van de overdracht van e en elektron: He 0 + Ne 0 -! He-(1s2s 2 ) +Ne + (2p 5 ) 3 10- 14 s -! He 0 (1s 2 ) +Ne + + e- (19.37 eV) He 0 + Ne 0 -! He + (1s) +Ne-(2p 5 3s 2 ) 2:5 10- 13 s -! He + (1s) +Ne 0 (2p 6 ) +e- (16.15 eV) De meetresultaten vertonen een fenomeen waarbij de bezettingen van de negatieve iontoestanden een oscillerend gedrag vertonen als functie van de botsingssnelheid. Dit duidt op interferentie tussen de twee bijna-ontaarde moleculaire toestanden [He- + Ne + ] en[He + + Ne-]. Het is echter zeer op- merkelijk dat deze oscillatie wordt waargenomen in een experiment als deze, waarin de uitgezonden elektronen worden gemeten ongeacht de afbuighoek van het heliumatoom. Dit impliceert een speciek aanslagmechanisme van de moleculaire negatieve iontoestanden. Nader beschouwing van het bots- ingssysteem laat zien dat het instantane molecuul twee overgangen moet ondergaan voordat de negatieve iontoestanden gevormd worden. Als gevolg hiervan is de snelheid waarmee het negatieve en positieve ion uit elkaar be- wegen nagenoeg onafhankelijk van de afbuighoek van het helium projectiel en is oscillatie mogelijk waarneembaar. De wisselwerking tussen de twee beschouwde moleculaire toestanden impliceert gecorreleerde overdracht van twee elektronen: He- + Ne + 2e- ! He + + Ne- Door het quasi-resonante systeem als resonant te beschouwen kan het fenomeen kwalitatief goed verklaard worden. 119?Samenvatting Inhet laatstedeelwordt de bevolkingvanauto¨oniserende natriumtoestanden bekeken in He +=0 + Na botsingen. In tegenstelling tot de voorgaande exper- imenten waarin elektronenoverdracht beschouwd werd, betreft het hier een excitatiemechanisme. De beschouwde `eind'producten, i.e. de auto¨oniserende natriumtoestanden, bestaan in het algemeen kort en gaan over naar een stabiele iontoestand onder uitzending van een elektron met een toestands- karakteristieke kinetische energie. Door de elektronenspectra te meten bij verschillende botsingsenergie¨en, wordt de bezetting van de auto¨oniserende toestanden onderzocht. Ook hier wordt het eect van laserexcitatie en laser- polarisatie van het natriumatoom op de vorming van deze toestanden, en de mate waarin, bekeken. De metingen laten zien dat zowel in He + -Na als in He 0 -Na botsingen de invloed van de ruimtelijk uitlijning van het buitenste natriumelektron op de elektronenspectra nihil is. Dit impliceert dat het betrokken 3p elektron hoofdzakelijk een passieve rol speelt in de vorming van auto¨oniserende toe- standen: het blijft hoofdzakelijk de 3p toestand bezetten als een `toeschouwer' zonder een overgang te maken naar een andere toestand. Dit wordt boven- dien bevestigd door het feit dat wanneer een fractie natriumatomen aange- slagen wordt naar de p toestand dit een even grote reductie betekent van onder meer de populatie van de auto¨oniserende toestand Na(2p 5 3s 2 ). De verwachte grote toename van Na(2p 5 3p 2 ) toestanden, in geval van Na(3p) doelwitten, is niet waargenomen. 120?121?122

  11. The first report of the vanC₁ gene in Enterococcus faecium isolated from a human clinical specimen.

    PubMed

    Sun, Mingyue; Wang, Yue; Chen, Zhongju; Zhu, Xuhui; Tian, Lei; Sun, Ziyong

    2014-09-01

    The vanC₁ gene, which is chromosomally located, confers resistance to vancomycin and serves as a species marker for Enterococcus gallinarum. Enterococcus faecium TJ4031 was isolated from a blood culture and harbours the vanC₁gene. Polymerase chain reaction (PCR) assays were performed to detect vanXYc and vanTc genes. Only the vanXYc gene was found in the E. faecium TJ4031 isolate. The minimum inhibitory concentrations of vancomycin and teicoplanin were 2 µg/mL and 1 µg/mL, respectively. Real-time reverse transcription-PCR results revealed that the vanC₁ and vanXYc genes were not expressed. Pulsed-field gel electrophoresis and southern hybridisation results showed that the vanC₁ gene was encoded in the chromosome. E. faecalis isolated from animals has been reported to harbour vanC₁gene. However, this study is the first to report the presence of the vanC₁gene in E. faecium of human origin. Additionally, our research showed the vanC₁gene cannot serve as a species-specific gene of E. gallinarum and that it is able to be transferred between bacteria. Although the resistance marker is not expressed in the strain, our results showed that E. faecium could acquire the vanC₁gene from different species.

  12. Tweede Serie Ergonomietests Lichtgewicht Bommenpakken (Second Series of Ergonomic Tests on Lightweight Bomb Disposal Suits)

    DTIC Science & Technology

    2007-12-01

    warmtebelastingtests vast te stellen en (sit-and-reach, stand-and-reach. abductie referentiewaarden te bepalen door het van de arnen, anteflexie van de armen ...volgende, bewegingbeperkingtests: sit-and-reach, stand-and-reach. abductie van de armen , anteflexie van de armen en beperking van zicht. Bij de sit-and...gebogen op de rand van een tafel en houdt de armen zo ver mogeijk gestrekt naar voren op tafel. Daarbij wordt de afstand vanaf de rand van de tafel tot

  13. Molecular Characterization of Enterococcus faecalis N06-0364 with Low-Level Vancomycin Resistance Harboring a Novel d-Ala-d-Ser Gene Cluster, vanL▿

    PubMed Central

    Boyd, David A.; Willey, Barbara M.; Fawcett, Darlene; Gillani, Nazira; Mulvey, Michael R.

    2008-01-01

    Enterococcus faecalis N06-0364, exhibiting a vancomycin MIC of 8 μg/ml, was found to harbor a novel d-Ala-d-Ser gene cluster, designated vanL. The vanL gene cluster was similar in organization to the vanC operon, but the VanT serine racemase was encoded by two separate genes, vanTmL (membrane binding) and vanTrL (racemase). PMID:18458129

  14. State of the Art High-Throughput Approaches to Genotoxicity: Flow Micronucleus, Ames II, GreenScreen and Comet

    EPA Pesticide Factsheets

    State of the Art High-Throughput Approaches to Genotoxicity: Flow Micronucleus, Ames II, GreenScreen and Comet (Presented by Dr. Marilyn J. Aardema, Chief Scientific Advisor, Toxicology, Dr. Leon Stankowski, et. al. (6/28/2012)

  15. Implementing Basic Education: An African Experience.

    ERIC Educational Resources Information Center

    Banya, Kingsley; Elu, Juliet

    1999-01-01

    Analyses some of the difficulties involved in implementing the recently approved Basic Education Program for primary and secondary education in Sierra Leone. Discusses issues such as funding, training, and retention of teachers, curriculum reform, language development, equipment and supplies, and evaluation. Concludes that political stability is…

  16. Using the Binomial Series to Prove the Arithmetic Mean-Geometric Mean Inequality

    ERIC Educational Resources Information Center

    Persky, Ronald L.

    2003-01-01

    In 1968, Leon Gerber compared (1 + x)[superscript a] to its kth partial sum as a binomial series. His result is stated and, as an application of this result, a proof of the arithmetic mean-geometric mean inequality is presented.

  17. 11. Photocopy of Photograph (original Print in the Coral Gables ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Photocopy of Photograph (original Print in the Coral Gables Public Library, Fishbaugh Collection, M 3809) Photographer unknown, 1923-25 PONCE DE LEON PLAZA, FROM CORAL WAY AND GRANADA BOULEVARD - Coral Gables (Entrances, Streets, Gates, & Squares), Coral Gables, Miami-Dade County, FL

  18. Women--Their Access to Education and Employment

    ERIC Educational Resources Information Center

    Literacy Discussion, 1975

    1975-01-01

    The Unesco National Commissions carried out a series of studies simultaneously in Argentina, the Ivory Coast, Lebanon, Sierra Leone, and Sri Lanka regarding the relationship between the educational opportunities and the opportunities of employment open to women. Basic conclusions of international scope are presented. (LH)

  19. Benefits and Costs of LORAN-C Expansion into the Eastern Caribbean.

    DTIC Science & Technology

    1981-01-01

    exported by Caribbean islands are sugar, citrus, rice, bananas , avocados, green coffee, and papaya. However, despite the fact that the Caribbean...Capt. Leon Flowers , Nassau, Bahamas 5. MARITIME ORGANIZATIONS o Maritime Transportation Research Board, Mr. Dave Mellor, Washington, D.C. o National

  20. Governance and Civic Education.

    ERIC Educational Resources Information Center

    Thompson, Ekundayo J. D., Ed.

    This book contains 13 papers on the socioeconomic development, legal, gender, philosophical, and human rights dimensions of state governance within the context of social, economic, and political processes in Sierra Leone and Kenya. The Political Literacy and Civic Education (PLACE) Project, which was sponsored by the British Overseas Development…

  1. Everybody's Problem: Novice Teachers in Disadvantaged Mexican Schools

    ERIC Educational Resources Information Center

    Martínez, Nora H.

    2014-01-01

    This paper explores the difficulties that novice teachers confront at two economically, socially, and academically disadvantaged schools in the state of Nuevo Leon, Mexico. The researchers employed the action research tradition. Problems were identified using participant observation during reflexive workshops conducted with novice teachers and…

  2. NCCU/BBRI-Duke/Urology Partnership In Prostate Cancer Research

    DTIC Science & Technology

    2011-06-01

    Joellen Schildkraut, Ph.D.; David Tulis , Ph.D.; Leon Sun, Ph 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES...Following Radical Prostatectomy among Men with Localized Prostate Cancer: A Community- Based Intervention Investigators: Dave Tulis Ph.D., NCCU/BBRI

  3. Liberia’s Post-War Development: Key Issues and U.S. Assistance

    DTIC Science & Technology

    2010-05-25

    former President Taylor was arrested in Nigeria and transferred to the Special Court for Sierra Leone (SCSL) to face war crimes charges. He was...50 War Crimes , Human Rights Cases, and Transitional Justice...56 Potential for War Crimes Tribunal in Liberia

  4. Women's Empowerment: The Role of Credit and Small Enterprise Development.

    ERIC Educational Resources Information Center

    Mason, Gwen

    1995-01-01

    The Grassroots Gender Empowerment Movement in Sierra Leone is a gender-focused program of small enterprise development and revolving loans that has brought a degree of economic independence, community development, gender awareness, improved living conditions, and empowerment to the women involved. (JOW)

  5. The Use of Ebola Convalescent Plasma to Treat Ebola Virus Disease in Resource-Constrained Settings: A Perspective From the Field

    PubMed Central

    van Griensven, Johan; De Weiggheleire, Anja; Delamou, Alexandre; Smith, Peter G.; Edwards, Tansy; Vandekerckhove, Philippe; Bah, Elhadj Ibrahima; Colebunders, Robert; Herve, Isola; Lazaygues, Catherine; Haba, Nyankoye; Lynen, Lutgarde

    2016-01-01

    The clinical evaluation of convalescent plasma (CP) for the treatment of Ebola virus disease (EVD) in the current outbreak, predominantly affecting Guinea, Sierra Leone, and Liberia, was prioritized by the World Health Organization in September 2014. In each of these countries, nonrandomized comparative clinical trials were initiated. The Ebola-Tx trial in Conakry, Guinea, enrolled 102 patients by 7 July 2015; no severe adverse reactions were noted. The Ebola-CP trial in Sierra Leone and the EVD001 trial in Liberia have included few patients. Although no efficacy data are available yet, current field experience supports the safety, acceptability, and feasibility of CP as EVD treatment. Longer-term follow-up as well as data from nontrial settings and evidence on the scalability of the intervention are required. CP sourced from within the outbreak is the most readily available source of anti-EVD antibodies. Until the advent of effective antivirals or monoclonal antibodies, CP merits further evaluation. PMID:26261205

  6. Detection of Zaire Ebola virus by real-time reverse transcription-polymerase chain reaction, Sierra Leone, 2014.

    PubMed

    Liu, Licheng; Sun, Yang; Kargbo, Brima; Zhang, Chuntao; Feng, Huahua; Lu, Huijun; Liu, Wenseng; Wang, Chengyu; Hu, Yi; Deng, Yongqiang; Jiang, Jiafu; Kang, Xiaoping; Yang, Honglei; Jiang, Yongqiang; Yang, Yinhui; Kargbo, David; Qian, Jun; Chen, Weijun

    2015-09-15

    During the 2014 Ebola virus disease (EVD) outbreak, a real-time quantitative polymerase chain reaction was established to detect and identify the Zaire Ebola virus. We describe the use of this assay to screen 315 clinical samples from EVD suspected person in Sierra Leone. The detection rate in blood samples was 77.81% (207/266), and there were relatively higher detection rate (79.32% and 81.42%, respectively) during the first two weeks after onset of symptoms. In the two weeks that followed, the detection rate declined to 66.67% and 25.00%, respectively. There was the highest virus load at the first week and then decreased. The detection rate in swab samples was 89.79% (44/49). This may be benefit from the included patients. 46 of 49 swab samples were collected from died patients. Taken together, the results presented here indicate that the assay specifically and sensitively detects Zaire Ebola virus. Copyright © 2015 Elsevier B.V. All rights reserved.

  7. "Optics 4 every1", the hands-on optics outreach program of the Universidad Autonoma de Nuevo Leon

    NASA Astrophysics Data System (ADS)

    Viera-González, Perla M.; Sánchez-Guerrero, Guillermo E.

    2016-09-01

    The Fisica Pato2 (Physics 4 every1) outreach group started as a need of hands-on activities and active Science demonstrations in the education for kids, teenagers and basic education teachers in Nuevo Leffon maintaining a main objective of spread the word about the importance of Optics and Photonics; for accomplish this objective, since November 2013 several outreach events are organized every year by the group. The program Optics 4 every1 is supported by the Facultad de Ciencias Fisico Matematicas of the Universidad Autonoma de Nuevo Leon and the International Society for Optics and Photonics and consist in quick hands-on activities and Optics demonstrations designed for teach basic optical phenomena related with light and its application in everyday life. During 2015, with the purpose of celebrate the International Year of Light 2015, the outreach group was involved in 13 different events and reached more than 8,000 people. The present work explains the activities done and the outcome obtained with this program.

  8. Clinical Features of and Risk Factors for Fatal Ebola Virus Disease, Moyamba District, Sierra Leone, December 2014–February 2015

    PubMed Central

    Haaskjold, Yngvar Lunde; Bolkan, Håkon Angell; Krogh, Kurt Østhuus; Jongopi, James; Lundeby, Karen Marie; Mellesmo, Sindre; Garcés, Pedro San José; Jøsendal, Ola; Øpstad, Åsmund; Svensen, Erling; Fuentes, Luis Matias Zabala; Kamara, Alfred Sandy; Riera, Melchor; Arranz, Javier; Roberts, David P.; Stamper, Paul D.; Austin, Paula; Moosa, Alfredo J.; Marke, Dennis; Hassan, Shoaib; Eide, Geir Egil; Berg, Åse

    2016-01-01

    The 2013–2016 outbreak of Ebola virus disease (EVD) in West Africa infected >28,000 people, including >11,000 who died, and disrupted social life in the region. We retrospectively studied clinical signs and symptoms and risk factors for fatal outcome among 31 Ebola virus–positive patients admitted to the Ebola Treatment Center in Moyamba District, Sierra Leone. We found a higher rate of bleeding manifestations than reported elsewhere during the outbreak. Significant predictors for death were shorter time from symptom onset to admission, male sex, high viral load on initial laboratory testing, severe pain, diarrhea, bloody feces, and development of other bleeding manifestations during hospitalization. These risk factors for death could be used to identify patients in need of more intensive medical support. The lack of fever in as many as one third of EVD cases may have implications for temperature-screening practices and case definitions. PMID:27268303

  9. Clinical Features of and Risk Factors for Fatal Ebola Virus Disease, Moyamba District, Sierra Leone, December 2014–February 2015

    DOE PAGES

    Haaskjold, Yngvar Lunde; Bolkan, Hakon Angell; Krogh, Kurt Osthuus; ...

    2016-09-01

    The current outbreak of Ebola virus disease (EVD) in West Africa has infected more than 28,000 people, killed more than 11,000 and disrupted social life. We studied retrospectively the clinical presentation and risk factors for fatal outcome among the 31 Ebola virus (EBV) positive patients admitted to the Ebola Treatment Center (ETC) in Moyamba District, Sierra Leone. We found a higher rate of bleeding manifestations than reported elsewhere during the current outbreak. Significant predictors for fatal outcome were shorter time from onset to admission, male sex, high viral load on initial lab test, severe pain, diarrhea, bloody stools, and developmentmore » of other bleeding manifestations during hospital admission. Awareness of risk factors for fatal outcome could be used to identify patients in need of more intensive medical support. The lack of fever in as much as a third of EVD cases may have implications for temperature screening practices and case definitions.« less

  10. Clinical Features of and Risk Factors for Fatal Ebola Virus Disease, Moyamba District, Sierra Leone, December 2014–February 2015

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Haaskjold, Yngvar Lunde; Bolkan, Hakon Angell; Krogh, Kurt Osthuus

    The current outbreak of Ebola virus disease (EVD) in West Africa has infected more than 28,000 people, killed more than 11,000 and disrupted social life. We studied retrospectively the clinical presentation and risk factors for fatal outcome among the 31 Ebola virus (EBV) positive patients admitted to the Ebola Treatment Center (ETC) in Moyamba District, Sierra Leone. We found a higher rate of bleeding manifestations than reported elsewhere during the current outbreak. Significant predictors for fatal outcome were shorter time from onset to admission, male sex, high viral load on initial lab test, severe pain, diarrhea, bloody stools, and developmentmore » of other bleeding manifestations during hospital admission. Awareness of risk factors for fatal outcome could be used to identify patients in need of more intensive medical support. The lack of fever in as much as a third of EVD cases may have implications for temperature screening practices and case definitions.« less

  11. Cholera Epidemic Associated with Consumption of Unsafe Drinking Water and Street-Vended Water—Eastern Freetown, Sierra Leone, 2012

    PubMed Central

    Nguyen, Von D.; Sreenivasan, Nandini; Lam, Eugene; Ayers, Tracy; Kargbo, David; Dafae, Foday; Jambai, Amara; Alemu, Wondimagegnehu; Kamara, Abdul; Islam, M. Sirajul; Stroika, Steven; Bopp, Cheryl; Quick, Robert; Mintz, Eric D.; Brunkard, Joan M.

    2014-01-01

    During 2012, Sierra Leone experienced a cholera epidemic with 22,815 reported cases and 296 deaths. We conducted a matched case-control study to assess risk factors, enrolling 49 cases and 98 controls. Stool specimens were analyzed by culture, polymerase chain reaction (PCR), and pulsed-field gel electrophoresis (PFGE). Conditional logistic regression found that consuming unsafe water (matched odds ratio [mOR]: 3.4; 95% confidence interval [CI]: 1.1, 11.0), street-vended water (mOR: 9.4; 95% CI: 2.0, 43.7), and crab (mOR: 3.3; 95% CI: 1.03, 10.6) were significant risk factors for cholera infection. Of 30 stool specimens, 13 (43%) showed PCR evidence of toxigenic Vibrio cholerae O1. Six specimens yielded isolates of V. cholerae O1, El Tor; PFGE identified a pattern previously observed in seven countries. We recommended ensuring the quality of improved water sources, promoting household chlorination, and educating street vendors on water handling practices. PMID:24470563

  12. Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016

    PubMed Central

    Scott, Janet T.; Baxter, Julia M.; Parkes, Craig K.; Dwivedi, Rahul; Czanner, Gabriela; Vandy, Matthew J.; Momorie, Fayiah; Fornah, Alimamy D.; Komba, Patrick; Richards, Jade; Sahr, Foday; Beare, Nicholas A.V.; Semple, Malcolm G.

    2017-01-01

    We conducted a case–control study in Freetown, Sierra Leone, to investigate ocular signs in Ebola virus disease (EVD) survivors. A total of 82 EVD survivors with ocular symptoms and 105 controls from asymptomatic civilian and military personnel and symptomatic eye clinic attendees underwent ophthalmic examination, including widefield retinal imaging. Snellen visual acuity was <6/7.5 in 75.6% (97.5% CI 63%–85.7%) of EVD survivors and 75.5% (97.5% CI 59.1%–87.9%) of controls. Unilateral white cataracts were present in 7.4% (97.5% CI 2.4%–16.7%) of EVD survivors and no controls. Aqueous humor from 2 EVD survivors with cataract but no anterior chamber inflammation were PCR-negative for Zaire Ebola virus, permitting cataract surgery. A novel retinal lesion following the anatomic distribution of the optic nerve axons occurred in 14.6% (97.5% CI 7.1%–25.6%) of EVD survivors and no controls, suggesting neuronal transmission as a route of ocular entry. PMID:28628441

  13. Pesticide residues in orange fruit from citrus orchards in Nuevo Leon State, Mexico.

    PubMed

    Suárez-Jacobo, Angela; Alcantar-Rosales, Victor Manuel; Alonso-Segura, Diana; Heras-Ramírez, Maria; Elizarragaz-De La Rosa, Dalau; Lugo-Melchor, Ofelia; Gaspar-Ramirez, Octavio

    2017-09-01

    Some international organisations established maximum residue limits (MRLs) in food to protect human health. Mexico lacks regulations in this matter, affecting national and international trade from agroindustry. The aim of this study was to diagnose pesticide residues in oranges from Nuevo Leon, México, in citrus orchards. In May 2014, 100 orange fruit samples were taken randomly from orchards and subjected to analysis for 93 pesticides at residual level by GC/QQQ-MS and LCQ-TOF-MS. Results showed the presence of 15 pesticide residues in the samples. The comparison of the residual levels of pesticides found in orange samples among the MRLs allowed by USA, EU and Japanese regulations demonstrated that all samples were below MRLs issued by USA and Japan. Some orange samples were above MRLs issued by the EU. This provides a basis to establish strategies in order to satisfy International Standards to protect human health and encourage Food Safety in Mexico.

  14. Cholera epidemic associated with consumption of unsafe drinking water and street-vended water--Eastern Freetown, Sierra Leone, 2012.

    PubMed

    Nguyen, Von D; Sreenivasan, Nandini; Lam, Eugene; Ayers, Tracy; Kargbo, David; Dafae, Foday; Jambai, Amara; Alemu, Wondimagegnehu; Kamara, Abdul; Islam, M Sirajul; Stroika, Steven; Bopp, Cheryl; Quick, Robert; Mintz, Eric D; Brunkard, Joan M

    2014-03-01

    During 2012, Sierra Leone experienced a cholera epidemic with 22,815 reported cases and 296 deaths. We conducted a matched case-control study to assess risk factors, enrolling 49 cases and 98 controls. Stool specimens were analyzed by culture, polymerase chain reaction (PCR), and pulsed-field gel electrophoresis (PFGE). Conditional logistic regression found that consuming unsafe water (matched odds ratio [mOR]: 3.4; 95% confidence interval [CI]: 1.1, 11.0), street-vended water (mOR: 9.4; 95% CI: 2.0, 43.7), and crab (mOR: 3.3; 95% CI: 1.03, 10.6) were significant risk factors for cholera infection. Of 30 stool specimens, 13 (43%) showed PCR evidence of toxigenic Vibrio cholerae O1. Six specimens yielded isolates of V. cholerae O1, El Tor; PFGE identified a pattern previously observed in seven countries. We recommended ensuring the quality of improved water sources, promoting household chlorination, and educating street vendors on water handling practices.

  15. Traffic related deaths in Nuevo Leon, Mexico: causes and associated factors.

    PubMed

    Arreola-Rissa, Carlos; Santos-Guzmán, Jesús; Esquivel-Guzmán, Adol; Mock, Charles N

    2008-01-01

    The effects of alcohol on mortality due to motor vehicle accidents was studied. During the first semester of 2003, a sample of 243 fatality victims of traffic-related accidents and their blood alcohol levels were analyzed in the state of Nuevo Leon, Mexico. The age-adjusted mortality rate for traffic accidents was 8.9/100000 pop. (13.2 for males and 3.21 for females, per 100000). Fatal accidents were more common in the Metropolitan Area (MA). Fatalities were four times greater in males and the mean age was 34.7+/-18.2 years. Blood alcohol was detected in almost half of the victims who were drivers of the vehicles; the other cases of fatalities may be associated with road/car condition, weather and other factors. Alcohol intoxication levels were primarily associated with male drivers ages 16 to 45 (p=0.029); levels increased with age. In females, alcohol played a lesser role, affecting mostly ages 31 to 45 y (p=0.055).

  16. [Distribution of Aedes albopictus (Skuse) in Nuevo León, México, 2001-2004].

    PubMed

    Orta-Pesina, Héctor; Mercado-Hernández, Roberto; Elizondo-Leal, José Fernando

    2005-01-01

    To determine the distribution of Aedes albopictus (Skuse) in Nuevo Leon between 2001 and 2004. Standardized methods were used to collect 6371 samples of mosquito's larvae from 167 sites. The proportions of samples positive for Ae. albopictus were obtained by municipality and year, using the software program Excel. There were 1179 samples positive for Ae. albopictus. This species was distributed over 10 municipalities, as follows: Five on the Gulf of Mexico Coastal Plains, which predominantly have a semi-warm, sub-humid climate, and precipitations almost year round (Allende, Montemorelos, Linares, General Teran, and Santiago); two (Sabinas Hidalgo, and Cadereyta) localized on the North American Great Plains, which have a warm, semiarid climate, and scarce precipitations. The final three were Apodaca, San Nicolas, and Escobedo distributed over the metropolitan area of Monterrey City. Up to January 2004, the second most important epidemiological vector in the transmission cycle of Ae. albopictus worldwide was found in ten municipalities of Nuevo Leon State, Mexico.

  17. Gene frequencies and admixture estimates in four Mexican urban centers.

    PubMed

    Lisker, R; Ramirez, E; Briceño, R P; Granados, J; Babinsky, V

    1990-12-01

    We studied 202 individuals from the city of Leon in Guanajuato state, 228 from Merida, Yucatan, 220 from Oaxaca, Oaxaca, and 257 from Saltillo, Coahuila, to learn the distribution of the ABO, MN, Rh, and Duffy blood groups, serum haptoglobin, albumin, and factor Bf types, and red cell hemoglobin and glucose-6-phosphate dehydrogenase types. With the gene frequencies obtained, we performed admixture measurements with a maximum likelihood method, obtaining a trihybrid model for black, Indian, and white ancestry with the following proportions: 0.084, 0.513, and 0.403 in Leon: 0.059, 0.512, and 0.429 in Merida; 0.018, 0.676, and 0.306 in Oaxaca; and 0.073, 0.547, and 0.380 in Saltillo. The general pattern has high Indian ancestry followed by white and black ancestry. This pattern is congruent with most other studies performed in Mexico, including the east coast, where Indian ancestry predominates despite a clear increase in the black contribution.

  18. Sequelae and Other Conditions in Ebola Virus Disease Survivors, Sierra Leone, 2015.

    PubMed

    Mohammed, Hamish; Vandy, Alren O; Stretch, Rebecca; Otieno, David; Prajapati, Mukesh; Calderon, Mauricio; Vandi, Mohamed

    2017-01-01

    We rapidly assessed the health of Ebola virus disease (EVD) survivors in Kenema, Sierra Leone, by reviewing medical charts of all patients attending the Survivor Clinic of Kenema Government Hospital. Data were abstracted on signs and symptoms at every attendance. As of November 2015, a total of 621 attendances by 115 survivors with laboratory-confirmed EVD were made to the Survivor Clinic. Most (60.9%) survivors were women. Survivors' median age was 28 years (range 0.25-70 years). Survivors attended the clinic a median of 5 times (range 1-21 times) each, and the median time from EVD discharge to attendance was 261 days (range 4-504 days). The most commonly reported signs and symptoms among the 621 attendances were headache (63.1%), fever (61.7%), and myalgia (43.3%). Because health needs of EVD survivors are complex, rapid chart reviews at survivor clinics should be repeated regularly to assess the extent of illness and prioritize service delivery.

  19. Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016.

    PubMed

    Steptoe, Paul J; Scott, Janet T; Baxter, Julia M; Parkes, Craig K; Dwivedi, Rahul; Czanner, Gabriela; Vandy, Matthew J; Momorie, Fayiah; Fornah, Alimamy D; Komba, Patrick; Richards, Jade; Sahr, Foday; Beare, Nicholas A V; Semple, Malcolm G

    2017-07-01

    We conducted a case-control study in Freetown, Sierra Leone, to investigate ocular signs in Ebola virus disease (EVD) survivors. A total of 82 EVD survivors with ocular symptoms and 105 controls from asymptomatic civilian and military personnel and symptomatic eye clinic attendees underwent ophthalmic examination, including widefield retinal imaging. Snellen visual acuity was <6/7.5 in 75.6% (97.5% CI 63%-85.7%) of EVD survivors and 75.5% (97.5% CI 59.1%-87.9%) of controls. Unilateral white cataracts were present in 7.4% (97.5% CI 2.4%-16.7%) of EVD survivors and no controls. Aqueous humor from 2 EVD survivors with cataract but no anterior chamber inflammation were PCR-negative for Zaire Ebola virus, permitting cataract surgery. A novel retinal lesion following the anatomic distribution of the optic nerve axons occurred in 14.6% (97.5% CI 7.1%-25.6%) of EVD survivors and no controls, suggesting neuronal transmission as a route of ocular entry.

  20. Prevalence of psychological symptoms among Ebola survivors and healthcare workers during the 2014-2015 Ebola outbreak in Sierra Leone: a cross-sectional study.

    PubMed

    Ji, Dong; Ji, Ying-Jie; Duan, Xue-Zhang; Li, Wen-Gang; Sun, Zhi-Qiang; Song, Xue-Ai; Meng, Yu-Hua; Tang, Hong-Mei; Chu, Fang; Niu, Xiao-Xia; Chen, Guo-Feng; Li, Jin; Duan, Hui-Juan

    2017-02-21

    The 2014-2015 Ebola epidemic was considered to be the largest and most complex outbreak, which caused 11,310 reported deaths. The epidemic disease can cause a mental health crisis, however, there is only a small amount of scientific literature available related to this health issue so far. We evaluated the psychological symptoms of 161 participants including Ebola survivors and healthcare workers in Sierra Leone, analyzed the impact of job classification, education level on psychological status. We found that the order of total general severity index (GSI) scores from high to low was EVD survivors, SL medical staff, SL logistic staff, SL medical students, and Chinese medical staff. There were 5 dimensions (obsession-compulsion, anxiety, hostility, phobic anxiety, and paranoid ideation) extremely high in EVD survivors. GSI were associated with university education negatively. We believed our information is necessary to develop the comprehensive emergency response plan for emerging infectious disease outbreak.

  1. Spatial entanglement of nonvacuum Gaussian states

    NASA Astrophysics Data System (ADS)

    Kiałka, Filip; Ahmadi, Mehdi; Dragan, Andrzej

    2016-06-01

    The vacuum state of a relativistic quantum field contains entanglement between regions separated by spacelike intervals. Such spatial entanglement can be revealed using an operational method introduced in [M. Rodriguez-Vazquez, M. del Rey, H. Westman, and J. Leon, Ann. Phys. (N.Y.) 351, 112 (2014), E. G. Brown, M. del Rey, H. Westman, J. Leon, and A. Dragan, Phys. Rev. D 91, 016005 (2015)]. In this approach, a cavity is instantaneously divided into halves by an introduction of an extra perfect mirror. Causal separation of the two regions of the cavity reveals nonlocal spatial correlations present in the field, which can be quantified by measuring particles generated in the process. We use this method to study spatial entanglement properties of nonvacuum Gaussian field states. In particular, we show how to enhance the amount of harvested spatial entanglement by an appropriate choice of the initial state of the field in the cavity. We find a counterintuitive influence of the initial entanglement between cavity modes on the spatial entanglement which is revealed by dividing the cavity in half.

  2. Evaluation of the benefits and risks of introducing Ebola community care centers, Sierra Leone.

    PubMed

    Kucharski, Adam J; Camacho, Anton; Checchi, Francesco; Waldman, Ron; Grais, Rebecca F; Cabrol, Jean-Clement; Briand, Sylvie; Baguelin, Marc; Flasche, Stefan; Funk, Sebastian; Edmunds, W John

    2015-03-01

    In some parts of western Africa, Ebola treatment centers (ETCs) have reached capacity. Unless capacity is rapidly scaled up, the chance to avoid a generalized Ebola epidemic will soon diminish. The World Health Organization and partners are considering additional Ebola patient care options, including community care centers (CCCs), small, lightly staffed units that could be used to isolate patients outside the home and get them into care sooner than otherwise possible. Using a transmission model, we evaluated the benefits and risks of introducing CCCs into Sierra Leone's Western Area, where most ETCs are at capacity. We found that use of CCCs could lead to a decline in cases, even if virus transmission occurs between CCC patients and the community. However, to prevent CCC amplification of the epidemic, the risk of Ebola virus-negative persons being exposed to virus within CCCs would have to be offset by a reduction in community transmission resulting from CCC use.

  3. Anatomy of a Hotspot: Chain and Seroepidemiology of Ebola Virus Transmission, Sukudu, Sierra Leone, 2015-16.

    PubMed

    Kelly, J Daniel; Barrie, Mohamed Bailor; Mesman, Annelies W; Karku, Sahr; Quiwa, Komba; Drasher, Michael; Schlough, Gabriel Warren; Dierberg, Kerry; Koedoyoma, Songor; Lindan, Christina P; Jones, James Holland; Chamie, Gabriel; Worden, Lee; Greenhouse, Bryan; Weiser, Sheri D; Porco, Travis C; Rutherford, George W; Richardson, Eugene T

    2018-03-28

    Studies have yet to include minimally symptomatic Ebola virus (EBOV) infections and unrecognized Ebola virus disease (EVD) in Ebola-related transmission chains and epidemiologic risk estimates. We conducted a cross-sectional, sero-epidemiological survey from October 2015 to January 2016 among 221 individuals living in quarantined households from November 2014 to February 2015 during the Ebola outbreak in the village of Sukudu, Sierra Leone. Of 48 EBOV-infected persons, 25% (95% confidence interval [CI], 14%-40%) had minimally symptomatic EBOV infections and 4% (95% CI, 1%-14%) were unrecognized EVD cases. The pattern of minimally symptomatic EBOV infections in the transmission chain was nonrandom (P < .001, permutation test). Not having lived in the same house as an EVD case was significantly associated with minimally symptomatic infection. This is the first study to investigate a chain of EBOV transmission inclusive of minimally symptomatic EBOV infections and unrecognized EVD. Our findings provide new insights into Ebola transmission dynamics and quarantine practices.

  4. 19 CFR 10.41a - Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... for inspection by Customs officials upon reasonable notice. (3) If the container does not exit the U.S... 19 Customs Duties 1 2014-04-01 2014-04-01 false Lift vans, cargo vans, shipping tanks, skids... Traffic § 10.41a Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of...

  5. 19 CFR 10.41a - Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... for inspection by Customs officials upon reasonable notice. (3) If the container does not exit the U.S... 19 Customs Duties 1 2012-04-01 2012-04-01 false Lift vans, cargo vans, shipping tanks, skids... Traffic § 10.41a Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of...

  6. 19 CFR 10.41a - Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... for inspection by Customs officials upon reasonable notice. (3) If the container does not exit the U.S... 19 Customs Duties 1 2013-04-01 2013-04-01 false Lift vans, cargo vans, shipping tanks, skids... Traffic § 10.41a Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of...

  7. First and Second Order Stokes Generation by SRS in Methane: Influence of Rep-Rate, Beam Quality and Astigmatism (Opwekking van Eerste en Tweede Orde Stokes d.m.v. SRS in Methaan: Invloed van de Pulsfrequentie, de Bundelkwaliteit en Astigmatisme)

    DTIC Science & Technology

    1992-09-01

    omzettings rendementen van circa 75% gehaad bij een ingangs- energie van 280 mJ. De mogelijkheden tot bet halen van een hoger rendement lijken...of rep-rate, beam quality and astigmatism DImi-Thu-B~mO ITA1EiM-tT-h lF I~~ ~~’ IAPR2 8 1993~ I ~Xtbai Uiitdw FJ.M. van Putten J.C. van den Heuvel RJ.L...Influence of rep-rate. beam quality and astigmatism author(s) : F.J.M. van Putten, I.C. van den Heuvel, R.J.L. Lerou institute : TNO Physics and

  8. Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin

    PubMed Central

    Phillips-Jones, Mary K.; Channell, Guy; Kelsall, Claire J.; Hughes, Charlotte S.; Ashcroft, Alison E.; Patching, Simon G.; Dinu, Vlad; Gillis, Richard B.; Adams, Gary G.; Harding, Stephen E.

    2017-01-01

    VanA-type resistance to glycopeptide antibiotics in clinical enterococci is regulated by the VanSARA two-component signal transduction system. The nature of the molecular ligand that is recognised by the VanSA sensory component has not hitherto been identified. Here we employ purified, intact and active VanSA membrane protein (henceforth referred to as VanS) in analytical ultracentrifugation experiments to study VanS oligomeric state and conformation in the absence and presence of vancomycin. A combination of sedimentation velocity and sedimentation equilibrium in the analytical ultracentrifuge (SEDFIT, SEDFIT-MSTAR and MULTISIG analysis) showed that VanS in the absence of the ligand is almost entirely monomeric (molar mass M = 45.7 kDa) in dilute aqueous solution with a trace amount of high molar mass material (M ~ 200 kDa). The sedimentation coefficient s suggests the monomer adopts an extended conformation in aqueous solution with an equivalent aspect ratio of ~(12 ± 2). In the presence of vancomycin over a 33% increase in the sedimentation coefficient is observed with the appearance of additional higher s components, demonstrating an interaction, an observation consistent with our circular dichroism measurements. The two possible causes of this increase in s – either a ligand induced dimerization and/or compaction of the monomer are considered. PMID:28397853

  9. In Vivo Fluorescence Confocal Microscopy to Investigate the Role of RhoC in Inflammatory Breast Cancer

    DTIC Science & Technology

    2005-04-01

    5084. 6. Colpaert CG, Vermeulen PB, Benoy I, Soubry A, van Roy F, van Beest P, Goovaerts G, Dirix LY, van Dam P, Fox SB, Harris AL, van MarckEA...cancer. Cancer Res 1999, 59: 5079-5084. 17 14. Colpaert CG, Vermeulen PB, Benoy I, Soubry A, van Roy F, van Beest P, Goovaerts G, Dirix LY, van Dam P...Ohira S, Feng Y, Nikaido T, Konishi I: Up- regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma. Lab

  10. Mentale Inzetbaarheid van Teams: Ontwikkeling van een Moden van Teamfunctioneren als Module voor SCOPE (Mental Readiness of Teams - Development of a Team Model as Module for SCOPE)

    DTIC Science & Technology

    2007-04-01

    inzetbaarheid van teams: ontwikkeling van een model van teamfunctioneren als module voor SCOPE Datumn april 2007 Auteur (s) R. de B~ruin C’. Vervvijs A.J...Datum april 2007 Programmaleider Projectleider Auteur (s) dr. W.A. Lotens, TNO Defensie en A.]. van Vijet, TNO Defensie en R. de Bruin Veiligheid...Deelnemers verwachten wel, in lijn met de theorie , dat een lage cohesie samenhangt met een lage effectiviteit. Een hoge cohesie, daarentegen, zou

  11. User Manual PIRATE Model, Release Beta 1.0. (Handleiding PIRATE model, versie Beta 1.0)

    DTIC Science & Technology

    1998-01-01

    Beperkingen van PIRATE 40 9 . Conclusies en aanbevelingen 41 10. Referenties 42 11 . Ondertekening 43 TNO-rapport FEL-97-A285 Inleiding Bij maritieme...Inhoud Inleiding 7 1.1 Doel van PIRATE 7 1.2 Werking van PIRATE 8 1.3 Opbouw van de handleiding 8 2. Bediening van PIRATE 9 2.1 Systeemvereisten 10...2.2 Installatie 10 2.3 Bediening van de gebruikersinterface 11 2.4 Gebruiken van de figuren in andere programmes 15 3. Radars, radars in PIRATE

  12. FIELD EVALUATION OF EVAPO-TRANSPIRATION (ET) CAPS

    EPA Science Inventory

    A field study was conducted to assess the ability of landfill covers to control percolation into the waste. Performance of one conventional cover was compared to that of two evapotranspiration (ET) tree covers, using large (7 x 14 m) lined lysimeters at the Leon County Solid W...

  13. Stimulating Language: Insights from TMS

    ERIC Educational Resources Information Center

    Devlin, Joseph T.; Watkins, Kate E.

    2007-01-01

    Fifteen years ago, Pascual-Leone and colleagues used transcranial magnetic stimulation (TMS) to investigate speech production in pre-surgical epilepsy patients and in doing so, introduced a novel tool into language research. TMS can be used to non-invasively stimulate a specific cortical region and transiently disrupt information processing. These…

  14. Photographic copy of postcard, ca. post1943 (original postcard located USACERL, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of postcard, ca. post-1943 (original postcard located USACERL, Champaign, IL). Kodachrome by Leon Greene, published exclusively for L.G.G. View of Balboa Elementary School, looking southwest. - Balboa School, Northeast end of El Prado, Balboa, Former Panama Canal Zone, CZ

  15. English as a Second Language: Current Issues.

    ERIC Educational Resources Information Center

    Lugton, Robert C., Ed.

    This collection contains articles on teaching English to foreign students which range in subject matter from transformational-generative grammar to programed learning and which reflect a variety of viewpoints. The following articles are included: Leon A. Jakobovits, "Prolegomena to a Theory of Communicative Competence"; Renzo Titone, "A…

  16. Latinos in the South.

    ERIC Educational Resources Information Center

    Shaw, Emily Elliott, Ed.

    2002-01-01

    This newsletter theme issue contains five articles about the growing Latino population in the South and its impact on communities, particularly in rural areas. "Social Capital of Mexican Communities in the South" (Ruben Hernandez-Leon, Victor Zuniga) argues that, to understand and advocate for Mexican newcomer communities in the South,…

  17. Mushrooms in the mist: stalking the wild chanterelle.

    Treesearch

    Sally. Duncan

    1999-01-01

    Commercial, recreational, and subsistence harvesting of chanterelle mushrooms in Washington's Olympic Peninsula has long been an issue for managers and harvesters alike. What guidelines should be used to manage nontimber products?Is there concern about possible increased commercial harvesting? Pacific Northwest Research Station scientist Leon Liegel and...

  18. Deaths, late deaths, and role of infecting dose in Ebola virus disease in Sierra Leone: retrospective cohort study.

    PubMed

    Bower, Hilary; Smout, Elizabeth; Bangura, Mohamed S; Kamara, Osman; Turay, Cecilia; Johnson, Sembia; Oza, Shefali; Checchi, Francesco; Glynn, Judith R

    2016-05-17

     To assess the frequency of fatal recrudescence from Ebola virus disease after discharge from treatment centres, and explore the influence of infecting dose on case fatality rates.  Retrospective cohort study.  Western Area, Sierra Leone.  151 survivors treated for Ebola virus disease at the Kerry Town treatment centre and discharged. Survivors were followed up for a vital status check at four to nine months after discharge, and again at six to 13 months after discharge. Verbal autopsies were conducted for four survivors who had died since discharge (that is, late deaths). Survivors still living in Western Area were interviewed together with their household members. Exposure level to Ebola virus disease was ascertained as a proxy of infecting dose, including for those who died.  Risks and causes of late death; case fatality rates; odds ratios of death from Ebola virus disease by age, sex, exposure level, date, occupation, and household risk factors.  Follow-up information was obtained on all 151 survivors of Ebola virus disease, a mean of 10 months after discharge. Four deaths occurred after discharge, all within six weeks: two probably due to late complications, one to prior tuberculosis, and only one after apparent full recovery, giving a maximum estimate of recrudescence leading to death of 0.7%. In these households, 395 people were reported to have had Ebola virus disease, of whom 227 died. A further 53 people fulfilled the case definition for probable disease, of whom 11 died. Therefore, the case fatality rate was 57.5% (227/395) for reported Ebola virus disease, or 53.1% (238/448) including probable disease. Case fatality rates were higher in children aged under 2 years and adults older than 30 years, in larger households, and in infections occurring earlier in the epidemic in Sierra Leone. There was no consistent trend of case fatality rate with exposure level, although increasing exposure increased the risk of Ebola virus disease.  In this study of survivors in Western Area, Sierra Leone, late recrudescence of severe Ebola virus disease appears to be rare. There was no evidence for an effect of infecting dose (as measured by exposure level) on the severity of disease. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  19. Projected Treatment Capacity Needs in Sierra Leone

    PubMed Central

    White, Richard A; MacDonald, Emily; de Blasio, Birgitte Freiesleben; Nygård, Karin; Vold, Line; Røttingen, John-Arne

    2015-01-01

    Background: The ongoing outbreak of Ebola Virus Disease in West Africa requires immediate and sustained input from the international community in order to curb transmission. The CDC has produced a model that indicates that to end the outbreak by pushing the reproductive number below one, 25% of the patients must be placed in an Ebola Treatment Unit (ETC) and 45% must be isolated in community settings in which risk of disease transmission is reduced and safe burials are provided. In order to provide firmer targets for the international response in Sierra Leone, we estimated the national and international personnel and treatment capacity that may be required to reach these percentages. Methods: We developed a compartmental SEIR model that was fitted to WHO data and local data allowing the reproductive number to change every 8 weeks to forecast the progression of the EVD epidemic in Sierra Leone. We used the previously estimated 2.5x correction factor estimated by the CDC to correct for underreporting. Number of personnel required to provide treatment for the predicted number of cases was estimated using UNMEER and UN OCHA requests for resources required to meet the CDC target of 70% isolation. Results: As of today (2014-12-04), we estimate that there are 810 (95% CI=646 to 973) EVD active cases in treatment, with an additional 3751 (95% CI=2778 to 4723) EVD cases unreported and untreated. To reach the CDC targets today, we need 1140 (95% CI=894 to 1387) cases in ETCs and 2052 (95% CI=1608 to 2496) at home or in a community setting with a reduced risk for disease transmission. In 28 days (2015-01-01), we will need 1309 (95% CI=804 to 1814) EVD cases in ETCs and 2356 (95% CI=1447 to 3266) EVD cases at reduced risk of transmission. If the current transmission rate is not reduced, up to 3183 personnel in total will be required in 56 days (2015-01-29) to operate ETCs according to our model. Conclusions: The current outbreak will require massive input from the international community in order to curb the transmission through traditional containment mechanisms by breaking the chains of transmission in Sierra Leone. If sufficient treatment facilities, healthcare workers and support personnel are not rapidly deployed, the increasing number of cases will be overwhelming.In addition to supporting isolation and treatment mechanisms, other viable control options, such as the development of an effective vaccine, should be supported. PMID:25685632

  20. Projected treatment capacity needs in sierra leone.

    PubMed

    White, Richard A; MacDonald, Emily; de Blasio, Birgitte Freiesleben; Nygård, Karin; Vold, Line; Røttingen, John-Arne

    2015-01-30

    The ongoing outbreak of Ebola Virus Disease in West Africa requires immediate and sustained input from the international community in order to curb transmission. The CDC has produced a model that indicates that to end the outbreak by pushing the reproductive number below one, 25% of the patients must be placed in an Ebola Treatment Unit (ETC) and 45% must be isolated in community settings in which risk of disease transmission is reduced and safe burials are provided. In order to provide firmer targets for the international response in Sierra Leone, we estimated the national and international personnel and treatment capacity that may be required to reach these percentages. We developed a compartmental SEIR model that was fitted to WHO data and local data allowing the reproductive number to change every 8 weeks to forecast the progression of the EVD epidemic in Sierra Leone. We used the previously estimated 2.5x correction factor estimated by the CDC to correct for underreporting. Number of personnel required to provide treatment for the predicted number of cases was estimated using UNMEER and UN OCHA requests for resources required to meet the CDC target of 70% isolation. As of today (2014-12-04), we estimate that there are 810 (95% CI=646 to 973) EVD active cases in treatment, with an additional 3751 (95% CI=2778 to 4723) EVD cases unreported and untreated. To reach the CDC targets today, we need 1140 (95% CI=894 to 1387) cases in ETCs and 2052 (95% CI=1608 to 2496) at home or in a community setting with a reduced risk for disease transmission. In 28 days (2015-01-01), we will need 1309 (95% CI=804 to 1814) EVD cases in ETCs and 2356 (95% CI=1447 to 3266) EVD cases at reduced risk of transmission. If the current transmission rate is not reduced, up to 3183 personnel in total will be required in 56 days (2015-01-29) to operate ETCs according to our model. The current outbreak will require massive input from the international community in order to curb the transmission through traditional containment mechanisms by breaking the chains of transmission in Sierra Leone. If sufficient treatment facilities, healthcare workers and support personnel are not rapidly deployed, the increasing number of cases will be overwhelming.In addition to supporting isolation and treatment mechanisms, other viable control options, such as the development of an effective vaccine, should be supported.

  1. Meet Cuban Ebola fighters: interview with Félix Báez and Jorge Pérez. A MEDICC Review exclusive.

    PubMed

    Báez, Félix; Pérez, Jorge; Reed, Gail

    2015-01-01

    Tramping through the Himalayan snows to treat patients after the 2005 Pakistan earthquake, internist Félix Báez could never have imagined he would be on the front lines of Ebola in Sierra Leone nine years later….much less that he would contract the deadly virus, live to tell the story and also to return to his team in Africa to continue the fight. At his side in the Geneva University Hospital, where he was airlifted, was Dr Jorge Pérez, today director of Cuba's Pedro Kourí Tropical Medicine Institute (IPK), but best known as "Cuba's AIDS doctor." Times have changed for both physicians, and Ebola is first on their minds as it rages on. At this writing, while there is cautious optimism in Liberia, the epidemic is not yet under control. Ebola has already infected nearly 22,000 people, taken over 8600 lives; Sierra Leone is one of the countries hardest hit. Among the sick and dying have been too many local health workers: 103 of the 138 infected, at last count. The first to sound the global alarm was Doctors Without Borders, which, like Cuba, already had health professionals on the ground in Africa; they were joined by many more, and Cuba was the country that offered the most assistance once WHO called for nations to step up with funds and, most importantly, human resources. Cuba sent 256 volunteers, all with significant international emergency experience: 38 to Guinea, 53 to Liberia and 165 to Sierra Leone. And more wait in the wings, specially-trained disaster medical workers who have already received their first round of Ebola courses at IPK. These Cuban and other international volunteers are bringing patients back from the brink of death, assisting national health workers and community educators. And people like Jorge Pérez are working to get to the bottom of Ebola to help prevent its spread throughout Africa and to other parts of the world. But to keep an epidemic like this from happening again, it will take more, much more. Not only could the global community have done a better job this time around. But as Jim Kim, President of the World Bank admonished, Ebola didn't start with disease, but rather with historic inequalities, the virus festering within health systems barely able to function. A lesson for us all. Hours before Dr Báez's return to Sierra Leone-where he is now-MEDICC Review interviewed him and Dr Pérez at IPK in Havana.

  2. Molecular epidemiology of vancomycin resistant enterococci in a tertiary care hospital in Saudi Arabia.

    PubMed

    Somily, Ali M; Al-Mohizea, Maha M; Absar, Muhammed M; Fatani, Amal J; Ridha, Afaaf M; Al-Ahdal, Mohammed N; Senok, Abiola C; Al-Qahtani, Ahmed A

    2016-08-01

    Vancomycin-resistant enterococci (VRE) are a major cause of nosocomial infections with high mortality and morbidity. There is limited data on the molecular characterization of VRE in Saudi Arabia. This study was carried out to investigate the premise that a shift in VRE epidemiology is occurring in our setting. Enterococcus species identification and susceptibility testing plus VRE phenotypic confirmation by vancomycin and teicoplanin E-test were carried out. Vancomycin resistance genes were detected by PCR. Strain typing was conducted using PFGE. Among the strains of Enterococcus spp. investigated in this study, 17 (4.5%) were VRE. With the exception of one isolate from rectal swab, all others were clinical specimens with blood being the commonest source (n = 11; 64.7%), followed by urine (n = 3; 17.6%). The 17 VRE isolates were Enterococcus faecium (n/N = 13/17) and Enterococcus gallinarum (n/N = 4/17). Among E. faecium isolates, vanA(+)/vanB(+) (n/N = 8/13; 62%) exhibiting VanB phenotype were predominant. One of the five vanA(+)E. faecium isolates exhibited a VanB phenotype indicative of vanA genotype-VanB phenotype incongruence. E. gallinarum isolates exhibited a Van C phenotype although two were vanA(+)/vanC1(+). PFGE revealed a polyclonal distribution with eight pulsotypes. These findings indicate an evolving VRE epidemiology with vanA(+)/vanB(+) isolates and vanA genotype-VanB phenotype incongruence isolates, which were previously described as colonizers, are now causing clinical infection. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. RpoS induces expression of the Vibrio anguillarum quorum-sensing regulator VanT.

    PubMed

    Weber, Barbara; Croxatto, Antony; Chen, Chang; Milton, Debra L

    2008-03-01

    In vibrios, regulation of the Vibrio harveyi-like LuxR transcriptional activators occurs post-transcriptionally via small regulatory RNAs (sRNAs) that destabilize the luxR mRNA at a low cell population, eliminating expression of LuxR. Expression of the sRNAs is modulated by the vibrio quorum-sensing phosphorelay systems. However, vanT mRNA, which encodes a LuxR homologue in Vibrio anguillarum, is abundant at low and high cell density, indicating that VanT expression may be regulated via additional mechanisms. In this study, Western analyses showed that VanT was expressed throughout growth with a peak of expression during late exponential growth. VanO induced partial destabilization of vanT mRNA via activation of at least one Qrr sRNA. Interestingly, the sigma factor RpoS significantly stabilized vanT mRNA and induced VanT expression during late exponential growth. This induction was in part due to RpoS repressing expression of Hfq, an RNA chaperone. RpoS is not part of the quorum-sensing regulatory cascade since RpoS did not regulate expression or activity of VanO, and RpoS was not regulated by VanO or VanT. VanT and RpoS were needed for survival following UV irradiation and for pigment and metalloprotease production, suggesting that RpoS works with the quorum-sensing systems to modulate expression of VanT, which regulates survival and stress responses.

  4. Chlorhexidine Induces VanA-Type Vancomycin Resistance Genes in Enterococci

    PubMed Central

    Bhardwaj, Pooja; Ziegler, Elizabeth

    2016-01-01

    Chlorhexidine is a bisbiguanide antiseptic used for infection control. Vancomycin-resistant E. faecium (VREfm) is among the leading causes of hospital-acquired infections. VREfm may be exposed to chlorhexidine at supra- and subinhibitory concentrations as a result of chlorhexidine bathing and chlorhexidine-impregnated central venous catheter use. We used RNA sequencing to investigate how VREfm responds to chlorhexidine gluconate exposure. Among the 35 genes upregulated ≥10-fold after 15 min of exposure to the MIC of chlorhexidine gluconate were those encoding VanA-type vancomycin resistance (vanHAX) and those associated with reduced daptomycin susceptibility (liaXYZ). We confirmed that vanA upregulation was not strain or species specific by querying other VanA-type VRE. VanB-type genes were not induced. The vanH promoter was found to be responsive to subinhibitory chlorhexidine gluconate in VREfm, as was production of the VanX protein. Using vanH reporter experiments with Bacillus subtilis and deletion analysis in VREfm, we found that this phenomenon is VanR dependent. Deletion of vanR did not result in increased chlorhexidine susceptibility, demonstrating that vanHAX induction is not protective against chlorhexidine. As expected, VanA-type VRE is more susceptible to ceftriaxone in the presence of sub-MIC chlorhexidine. Unexpectedly, VREfm is also more susceptible to vancomycin in the presence of subinhibitory chlorhexidine, suggesting that chlorhexidine-induced gene expression changes lead to additional alterations in cell wall synthesis. We conclude that chlorhexidine induces expression of VanA-type vancomycin resistance genes and genes associated with daptomycin nonsusceptibility. Overall, our results indicate that the impacts of subinhibitory chlorhexidine exposure on hospital-associated pathogens should be further investigated in laboratory studies. PMID:26810654

  5. Factors Affecting Female Participation in Education in Seven Developing Countries. Second Edition. Education Research Paper.

    ERIC Educational Resources Information Center

    Brock, Colin; Cammish, Nadine

    Factors affecting female participation in education in seven developing countries were examined through field visits to the following countries: Bangladesh, Cameroon, India, Jamaica, Seychelles, Sierra Leone, and Vanuatu. In each country, researchers interviewed key personnel, consulted local documentation, and conducted two empirical surveys…

  6. SHORT COURSE IN MENDE.

    ERIC Educational Resources Information Center

    SPEARS, RICHARD A.

    THIS SHORT COURSE IN MENDE (A TONE LANGUAGE OF LIBERIA AND SIERRA LEONE) IS AN ABRIDGEMENT OF THE BASIC COURSE IN MENDE AND CONSISTS OF THE MOST "IMMEDIATELY USEFUL" PARTS OF THE BASIC COURSE. THESE PARTS INCLUDE A VOCABULARY, USEFUL PHRASES, AND "NARRATIVE DRILLS" TO BE USED WITH THE ACCOMPANYING 18 SLIDES, IN ADDITION TO…

  7. A Portfolio of Outstanding Contemporary American Indians.

    ERIC Educational Resources Information Center

    Wood, Theodore E. B.

    The portfolio contains 24 portraits with biographical sketches of outstanding contemporary American Indians. Representing several tribes, occupations, and points of view, the subjects are: Henry Adams, Louis W. Ballard, Robert L. Bennett, George Blue Spruce, Jarrett Blythe, Louis R. Bruce, Leon Cook, Ada Deer, Vine Deloria, Jr., James Gladstone,…

  8. Recent Technology Developments for the Kinetic Kill Vehicle Hardware-In-The-Loop Simulator (KHILS),

    DTIC Science & Technology

    1998-01-01

    Eric Hardware-in-the-Loop Testing III, Proceedings Hedlund, and Chet DeCesaris whose sponsorship SPIE 3368, (1998). through the SDIO/BMDO over the last...Jones, Coker, Garbo, Olson, Murrer, Bergin, Goldsmith, Crow, Guertin, Daugherty, Marler , 6. Trolier, Hall, Tincher, Leone, "Aerothermal Timms

  9. Krio Language Manual. Revised Edition.

    ERIC Educational Resources Information Center

    Peace Corps, Freetown (Sierra Leone).

    Instructional materials for Krio, the creole spoken in Sierra Leone, are designed for Peace Corps volunteer language instruction and intended for the use of both students and instructors. Fifty-six units provide practice in language skills, particularly oral, geared to the daily language needs of volunteers. Lessons are designed for audio-lingual…

  10. Moving beyond the Emergence of the CDO

    ERIC Educational Resources Information Center

    Stevenson, Michael R.

    2014-01-01

    Herein, M. R. Stevenson comments on R. A. Leon's "Journal of Diversity in Higher Education" article ("The Chief Diversity Officer: An Examination of CDO Models and Strategies") that focuses on the role of the chief diversity officer (CDO) in higher education. Stevenson suggests that the article is a groundbreaking…

  11. Interdisciplinarity and the Teaching of Public Policy

    ERIC Educational Resources Information Center

    Szostak, Rick

    2005-01-01

    De Leon and Steelman (2001) addressed three deficiencies in public policy programs. This paper focuses on the first of these, arguing that public policy students can and should be exposed to a comprehensive classification of types of ethical analysis. It then briefly addresses the two other deficiencies, again with recourse to recent…

  12. The Israeli Defense Forces: An Organizational Prospective

    DTIC Science & Technology

    1990-03-01

    Ideology was born of memory, as expressed in the following dialogue from a book by Leon Uris (a well-known author of the Jewish experience): 29 I...Left out of the picture by Dayan, the planning staffs were reduced to monitoring the battle through secondhand sources. f . Ideology The religious

  13. CULTURAL FRONTIERS OF THE PEACE CORPS.

    ERIC Educational Resources Information Center

    TEXTOR, ROBERT B., ED.

    THE PRESENT WORK CONTAINS ANALYSES OF PEACE CORPS PROGRAMS IN SELECTED HOST COUNTRIES (THE PHILIPPINES, MALAYA, THAILAND, PERU, BOLIVIA, AFGHANISTAN, SOMALIA, NIGERIA, TANGANYIKA, SIERRA LEONE, TUNISIA, MOROCCO, AND JAMAICA) WRITTEN BY AN AUTHORITY ON EACH COUNTRY. COVERAGE OF DOMESTIC OPERATIONS OF THE PEACE CORPS IS STRICTLY LIMITED TO WHAT IS…

  14. 75 FR 60137 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-29

    ... Leon County Woman's Working Band House, 648 W Brevard St, Tallahassee, 10000848 KANSAS Phillips County... Montauk HWY, Hampton Bays, 10000852 Ulster County Lattingtown Baptist Church, 425 Old Indian Rd, Lattingtown, 10000855 Westchester County Woman's Club of White Plains, 305 Ridgeway, White Plains, 10000853...

  15. Apparatus Named after Our Academic Ancestors, III

    ERIC Educational Resources Information Center

    Greenslade, Thomas B., Jr.

    2014-01-01

    My academic ancestors in physics have called on me once more to tell you about the apparatus that they devised, and that many of you have used in your demonstrations and labs. This article is about apparatus named after François Arago, Heinrich Helmholtz, Leon Foucault, and James Watt.

  16. Inhibition and Language Pragmatic View in Redundant Data Problem Solving

    ERIC Educational Resources Information Center

    Setti, Annalisa; Caramelli, Nicoletta

    2007-01-01

    The present study concerns redundant data problems, defined as problems in which irrelevant data is provided. This type of problem provides a misleading context [Pascual-Leone, J. (1987). Organismic process for neo-Piagetian theories: A dialectical causal account of cognitive development. "International Journal of Psychology," 22, 531-570] similar…

  17. 75 FR 44841 - Agency Information Collection Activities; Revision of a Currently-Approved Information Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-29

    ... Request: Transportation of Household Goods; Consumer Protection AGENCY: Federal Motor Carrier Safety... request (ICR), ``Transportation of Household Goods; Consumer Protection,'' OMB Control Number 2126-0025...: Respondents: 8,500 [6,000 household goods movers + 2,500 consumers]. Issued on: July 23, 2010. Kelly Leone...

  18. Opportunities for Distance Education in the Commonwealth African Countries.

    ERIC Educational Resources Information Center

    INTELECON Research & Consultancy Ltd., Vancouver (British Columbia).

    The geo-demographic, economic, and infrastructural makeup of 12 African countries (Botswana. Gambia, Kenya, Lesotho, Malawi, Nigeria, Sierra Leone, Swaziland, Tanzania, Uganda, Zambia, and Zimbabwe) were compared to determine the potential benefits to them of a Commonwealth of Learning (COL) distance education initiative. Data were collected on…

  19. Readings in Applied Transformational Grammar.

    ERIC Educational Resources Information Center

    Lester, Mark, Ed.

    This volume contains nineteen essays, dealing with various aspects of transformational grammar, by scholars such as Noam Chomsky, Eric H. Lenneberg, and Leon Jakobovits. These essays have been reprinted from sources such as "College English" and "Language Learning" and are intended for the most part for a nontechnical audience. The anthology is…

  20. Do Girls' Scholarship Programs Work? Evidence from Two Countries

    ERIC Educational Resources Information Center

    Chapman, David W.; Mushlin, Sarah

    2008-01-01

    This study examined the extent that a scholarship program operating in Sierra Leone and Djibouti was successful in increasing girls' persistence in basic education. Results of field studies indicated that scholarships could be appropriately targeted and delivered in ways that appear to minimize misappropriation of funds. However, the scholarships…

  1. Health information for the grass roots.

    PubMed

    M'Jamtu-Sie, N

    1996-01-01

    In its endeavours to achieve the health-for-all goals, Sierra Leone confronts many formidable obstacles, among the greatest of which are illiteracy and poverty. Nevertheless, determined efforts are being made to disseminate health messages, including advice on self-help in the prevention of diseases and accidents and in tackling illness and disability.

  2. Teasing Out Cognitive Development from Cognitive Style: A Training Study.

    ERIC Educational Resources Information Center

    Globerson, Tamar; And Others

    1985-01-01

    Tested whether or not cognitive development (as measured by mental capacity) and cognitive style (as measured by field-dependence/independence) are different dimensions. Results are discussed with regard to Pascual-Leone's model of cognitive development, relevance to stylistic dimension of reflection/impulsivity, and educational implications.…

  3. Mende Language Manual. Revised Edition.

    ERIC Educational Resources Information Center

    Musa, Allieu V. V.; Pemagbi, Joe

    A set of instructional materials for Mende is designed for Peace Corps volunteer language instruction and geared to the daily language needs of volunteers in Sierra Leone. It consists of two parts, a series of lessons on situations emphasizing vocabulary development through dialogues and drills, and a series of grammar lessons. Only the first…

  4. The Latin American Challenge and Army Hispanic Soldier Policy

    DTIC Science & Technology

    1986-02-18

    FLA MG Edward Baca, TAG, New Mexico National Guard, New Mexico MG Belisario Flores, Asst AG, Air National Guard, Texas RA Diego Hernandez , Roosevelt...Marc A. Cisneros, Div Arty Cdr, Ft Hood, TX COL Samuel Malave-Garcia, Port Cdr, Rotterdam, Neth COL(ARNG Ret) Gustavo Leon, Former ARNG Senior Advisor

  5. IFLA General Conference, 1986. Pre-Session Seminar, Kanasawa. Papers.

    ERIC Educational Resources Information Center

    International Federation of Library Associations and Institutions, The Hague (Netherlands).

    The two papers in this document were presented at a pre-session held before the IFLA general conference in 1986. In "Problems of Document Delivery in the Science and Technology Information Environment--An African View," Lucilda Hunter (Sierra Leone) discusses typical difficulties encountered in the process of information retrieval in…

  6. Phonological Stereotypes and Names in Temne.

    ERIC Educational Resources Information Center

    Nemer, Julie F.

    1987-01-01

    Many personal names in Temne (a Mel language spoken in Sierra Leone) are borrowed from other languages, containing foreign sounds and sequences which are unpronounceable for Temne speakers when they appear in other words. These exceptions are treated as instances of phonological stereotyping (cases remaining resistant to assimilation processes).…

  7. Tussenrapportage Validatie Onderwijsvernieuwingen (Validation Assistant in Instructional Design)

    DTIC Science & Technology

    2007-05-01

    validatie onderwij svemieuwingen D)atum mei 2007 Auteur (s) drs. J.P. van Meer drs. G,J. Veldhuis dr. M.L. van Ernmerik M.G. van Schaik Rubricering...als doel om nog beter is het van belang dat het maken van keuzes Auteur (s) passende adviezen te kunnen genereren. binnen een moeilijk grijpbaar...benaderd door de theorie achter de onderwijsconcepten te toetsen aan het oordeel van de expert. Er zijn echter beperkingen in deze opzet denkbaar die

  8. Emergence of vanA Enterococcus faecium in Denmark, 2005-15.

    PubMed

    Hammerum, Anette M; Baig, Sharmin; Kamel, Yasmin; Roer, Louise; Pinholt, Mette; Gumpert, Heidi; Holzknecht, Barbara; Røder, Bent; Justesen, Ulrik S; Samulioniené, Jurgita; Kjærsgaard, Mona; Østergaard, Claus; Holm, Anette; Dzajic, Esad; Søndergaard, Turid Snekloth; Gaini, Shahin; Edquist, Petra; Alm, Erik; Lilje, Berit; Westh, Henrik; Stegger, Marc; Hasman, Henrik

    2017-08-01

    To describe the changing epidemiology of vancomycin-resistant Enterococcus faecium and Enterococcus faecalis in clinical samples in Denmark 2005-15 according to species and van type, and, furthermore, to investigate the genetic relatedness of the clinical E. faecium isolates from 2015. During 2005-14, all clinical VRE isolates were tested for the presence of vanA/B/C genes by PCR. In 2015, all clinical VRE isolates were whole-genome sequenced. From the WGS data, the presence of van genes and MLST STs were extracted in silico . Core-genome MLST (cgMLST) analysis was performed for the vancomycin-resistant E. faecium isolates. During 2005-15, 1043 vanA E. faecium , 25 vanB E. faecium , 4 vanA E. faecalis and 28 vanB E. faecalis were detected. The number of VRE was <50 isolates/year until 2012 to > 200 isolates/year in 2013-15. In 2015, 368 vanA E. faecium and 1 vanB E. faecium were detected along with 1 vanA E. faecalis and 1 vanB E. faecalis . cgMLST subdivided the 368 vanA E. faecium isolates into 33 cluster types (CTs), whereas the vanB E. faecium isolate belonged to a different CT. ST203-CT859 was most prevalent (51%), followed by ST80-CT14 (22%), ST117-CT24 (6%), ST80-CT866 (4%) and ST80-CT860 (2%). Comparison with the cgMLST.org database, previous studies and personal communications with neighbouring countries revealed that the novel cluster ST203-CT859 emerged in December 2014 and spread to the south of Sweden and the Faroe Islands during 2015. VRE increased in Denmark during 2005-15 due to the emergence of several vanA E. faecium clones. © The Author 2017. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  9. Vancomycin-resistance phenotypes, vancomycin-resistance genes, and resistance to antibiotics of enterococci isolated from food of animal origin.

    PubMed

    Gousia, Panagiota; Economou, Vangelis; Bozidis, Petros; Papadopoulou, Chrissanthy

    2015-03-01

    In the present study, 500 raw beef, pork, and chicken meat samples and 100 pooled egg samples were analyzed for the presence of vancomycin-resistant enterococci, vancomycin-resistance phenotypes, and resistance genes. Of 141 isolates of enterococci, 88 strains of Enterococcus faecium and 53 strains of E. faecalis were identified. The most prevalent species was E. faecium. Resistance to ampicillin (n = 93, 66%), ciprofloxacin (n = 74, 52.5%), erythromycin (n = 73, 51.8%), penicillin (n = 59, 41.8%) and tetracycline (n = 52, 36.9%) was observed, while 53.2% (n = 75) of the isolates were multiresistant and 15.6% (n = 22) were susceptible to all antibiotics. Resistance to vancomycin was exhibited in 34.1% (n = 30) of the E. faecium isolates (n = 88) and 1.9% (n = 1) of the E. faecalis isolates (n = 53) using the disc-diffusion test and the E-test. All isolates were tested for vanA and vanB using real-time polymerase chain reaction (PCR) and multiplex PCR, and for vanC, vanD, vanE, vanG genes using multiplex PCR only. Among E. faecalis isolates, no resistance genes were identified. Among the E. faecium isolates, 28 carried the vanA gene when tested by multiplex PCR and 29 when tested with real-time PCR. No isolate carrying the vanC, vanD, vanE, or vanG genes was identified. Melting-curve analysis of the positive real-time PCR E. faecium isolates showed that 22 isolates carried the vanA gene only, 2 isolates the vanB2,3 genes only, and seven isolates carried both the vanA and vanB2,3 genes. Enterococci should be considered a significant zoonotic pathogen and a possible reservoir of genes encoding resistance potentially transferred to other bacterial species.

  10. Wind and Current Forces Acting on Canadian Forces Ships During Tug Operations

    DTIC Science & Technology

    2002-11-01

    McTaggart and Sav- age [1] describe model tests conducted on a generic frigate model to determine wind forces influencing ship capsize. Van Manen and van ...Fn will be 0.06. Based on data presented by van Manen and van Oossanen [2], the fric- tional resistance coefficient will be approximately 0.002 and...Conference on Stability of Ships and Ocean Vehicles (Melbourne, Florida, 1994). 2. J.D. van Manen and P. van Oossanen, Principles of Naval Architecture, Volume

  11. Softwaremodule voor het Simuleren van de Gevolgen van Raketonderschepping (The Dutch Program for the Simulation of Missile Intercept Effects)

    DTIC Science & Technology

    2007-07-01

    effects (Softwaremodule voor het simuleren van de gevolgen van raketonderschepping) 11 . AUTHOR(S) Dr E. Abadjieva, MSc R.P. Sterkenburg, MSc F. Bouquet...Softwaremnodule voor het simuleren van de gevolgen van raketonderschepping D)attini Juli 2007 Auteur(s) dr. F. Abadjicva ir. R.P Sterkenburg ir. F. Bouquet ir...P.W. D)ouip Rubricering rapport O)ngerubri ceerd Vastgesteld door Maj R. 11 . Jongkinid Vastgesteld d.d. 12 juni 2007 (Deze nitining mizil-4 sict

  12. Synergistic Interactions of Vancomycin with Different Antibiotics against Escherichia coli: Trimethoprim and Nitrofurantoin Display Strong Synergies with Vancomycin against Wild-Type E. coli

    PubMed Central

    Zhou, Alice; Kang, Tina Manzhu; Yuan, Jessica; Beppler, Casey; Nguyen, Caroline; Mao, Zhiyuan; Nguyen, Minh Quan

    2014-01-01

    Gram-negative bacteria are normally resistant to the antibiotic vancomycin (VAN), which cannot significantly penetrate the outer membrane. We used Escherichia coli mutants that are partially sensitive to VAN to study synergies between VAN and 10 other antibiotics representing six different functional categories. We detected strong synergies with VAN and nitrofurantoin (NTR) and with VAN and trimethoprim (TMP) and moderate synergies with other drugs, such as aminoglycosides. These synergies are powerful enough to show the activity of VAN against wild-type E. coli at concentrations of VAN as low as 6.25 μg/ml. This suggests that a very small percentage of exogenous VAN does enter E. coli but normally has insignificant effects on growth inhibition or cell killing. We used the results of pairwise interactions with VAN and the other 10 antibiotics tested to place VAN into a functional category of its own, as previously defined by Yeh et al. (P. Yeh, A. I. Tschumi, and R. Kishony, Nat Genet 28:489–494, 2006, http://dx.doi.org/10.1038/ng1755). PMID:25348521

  13. Glucagon-like peptide-1 regulates brown adipose tissue thermogenesis via the gut-brain axis in rats.

    PubMed

    Krieger, Jean-Philippe; Santos da Conceição, Ellen Paula; Sanchez-Watts, Graciela; Arnold, Myrtha; Pettersen, Klaus G; Mohammed, Mazher; Modica, Salvatore; Lossel, Pius; Morrison, Shaun F; Madden, Christopher J; Watts, Alan G; Langhans, Wolfgang; Lee, Shin J

    2018-05-30

    Endogenous intestinal glucagon-like peptide-1 (GLP-1) controls satiation and glucose metabolism via vagal afferent neurons (VAN). Recently, VAN have received increasing attention for their role in brown adipose tissue (BAT) thermogenesis. It is however unclear whether VAN GLP-1 receptor (GLP-1R) signaling affects BAT thermogenesis and energy expenditure (EE), and whether this VAN mechanism contributes to energy balance. First, we tested the effect of the GLP-1R agonist Exendin-4 (Ex4, 0.3 μg/kg IP) on EE and BAT thermogenesis, and whether these effects require VAN GLP-1R signaling, using a rat model with a selective Glp1r knockdown (kd) in VAN. Second, we examined the role of VAN GLP-1R in energy balance during chronic high-fat diet (HFD) feeding in VAN Glp1r kd rats. Lastly, we used viral transsynaptic tracers to identify the possible neuronal substrates of such a gut-BAT interaction. VAN Glp1r kd attenuated the acute suppressive effects of Ex4 on EE and BAT thermogenesis. Consistent with this finding, the VAN Glp1r kd increased EE and BAT activity, diminished body weight gain, and improved insulin sensitivity compared to HFD-fed controls. Anterograde transsynaptic viral tracing of VAN infected major hypothalamic and hindbrain areas involved in BAT sympathetic regulation. Moreover, retrograde tracing from BAT combined with laser capture microdissection revealed that a population of VAN expressing Glp1r is synaptically connected to the BAT. Our findings reveal a novel role of VAN GLP-1R signaling in the regulation of EE and BAT thermogenesis, and imply that through this gut-brain-BAT connection intestinal GLP-1 plays a role in HFD-induced metabolic syndrome.

  14. Evaluatie Kennistechnologische Ondersteuning bij Diagnose van SEWACO systemen (Projectmanagementplan) (Evaluation of Knowledge Technological Support for Diagnosis of SEWACO Systems (Project Management Plan)

    DTIC Science & Technology

    1991-08-01

    diagnos van SE WACO systmnen/ AD-A245 424111 1fl1,l Niets uit deze uitgave mag warden vermenigvuldligd en/of oPenbaar gemaakt door middel van druk...fotakopie. microfilm of op welks andere whlze dan ook, zonder voorafgaande toeslemming van TNO. Hot ter inzage geven van het TNO-rapport aan direct...belanghebbenden is tegestaan. HYP. vanl OC dt Indian dit rapport in opdracht ward uitgebracht, wordt voor de, rechten en verpiichtingen van opdrachtgever en

  15. The phosphotransferase VanU represses expression of four qrr genes antagonizing VanO-mediated quorum-sensing regulation in Vibrio anguillarum

    PubMed Central

    Weber, Barbara; Lindell, Kristoffer; El Qaidi, Samir; Hjerde, Erik; Willassen, Nils-Peder

    2011-01-01

    Vibrio anguillarum utilizes quorum sensing to regulate stress responses required for survival in the aquatic environment. Like other Vibrio species, V. anguillarum contains the gene qrr1, which encodes the ancestral quorum regulatory RNA Qrr1, and phosphorelay quorum-sensing systems that modulate the expression of small regulatory RNAs (sRNAs) that destabilize mRNA encoding the transcriptional regulator VanT. In this study, three additional Qrr sRNAs were identified. All four sRNAs were positively regulated by σ54 and the σ54-dependent response regulator VanO, and showed a redundant activity. The Qrr sRNAs, together with the RNA chaperone Hfq, destabilized vanT mRNA and modulated expression of VanT-regulated genes. Unexpectedly, expression of all four qrr genes peaked at high cell density, and exogenously added N-acylhomoserine lactone molecules induced expression of the qrr genes at low cell density. The phosphotransferase VanU, which phosphorylates and activates VanO, repressed expression of the Qrr sRNAs and stabilized vanT mRNA. A model is presented proposing that VanU acts as a branch point, aiding cross-regulation between two independent phosphorelay systems that activate or repress expression of the Qrr sRNAs, giving flexibility and precision in modulating VanT expression and inducing a quorum-sensing response to stresses found in a constantly changing aquatic environment. PMID:21948044

  16. The phosphotransferase VanU represses expression of four qrr genes antagonizing VanO-mediated quorum-sensing regulation in Vibrio anguillarum.

    PubMed

    Weber, Barbara; Lindell, Kristoffer; El Qaidi, Samir; Hjerde, Erik; Willassen, Nils-Peder; Milton, Debra L

    2011-12-01

    Vibrio anguillarum utilizes quorum sensing to regulate stress responses required for survival in the aquatic environment. Like other Vibrio species, V. anguillarum contains the gene qrr1, which encodes the ancestral quorum regulatory RNA Qrr1, and phosphorelay quorum-sensing systems that modulate the expression of small regulatory RNAs (sRNAs) that destabilize mRNA encoding the transcriptional regulator VanT. In this study, three additional Qrr sRNAs were identified. All four sRNAs were positively regulated by σ(54) and the σ(54)-dependent response regulator VanO, and showed a redundant activity. The Qrr sRNAs, together with the RNA chaperone Hfq, destabilized vanT mRNA and modulated expression of VanT-regulated genes. Unexpectedly, expression of all four qrr genes peaked at high cell density, and exogenously added N-acylhomoserine lactone molecules induced expression of the qrr genes at low cell density. The phosphotransferase VanU, which phosphorylates and activates VanO, repressed expression of the Qrr sRNAs and stabilized vanT mRNA. A model is presented proposing that VanU acts as a branch point, aiding cross-regulation between two independent phosphorelay systems that activate or repress expression of the Qrr sRNAs, giving flexibility and precision in modulating VanT expression and inducing a quorum-sensing response to stresses found in a constantly changing aquatic environment.

  17. Review of Stantonia Ashmead (Hymenoptera, Braconidae, Orgilinae) from Vietnam, China, Japan, and Russia, with descriptions of six new species

    PubMed Central

    van Achterberg, Cornelis; Long, Khuat Dang; Chen, Xue-xin

    2017-01-01

    Abstract The genus Stantonia Ashmead, 1904 (Hymenoptera, Braconidae, Orgilinae) is reviewed for Vietnam, China, Japan, and Russia. Six new species of the genus Stantonia are described and illustrated: Stantonia brevicaudata van Achterberg, sp. n., S. dickyyui van Achterberg & Long, sp. n., S. granulata Long & van Achterberg, sp. n., S. robustifemur van Achterberg & Long, sp. n., S. stilpnosoma Long & van Achterberg, sp. n., and S. vietnamica van Achterberg, sp. n. A new subgenus (Planitonia subg. n.: type species Stantonia robustifemur van Achterberg & Long, sp. n.) is proposed for the species with a flat clypeus and face, and reduced vein r-m of the fore wing. Three species are newly recorded from Vietnam: Stantonia gracilis van Achterberg, 1987, S. sumatrana Enderlein, 1908, and S. tianmushana Chen, He & Ma, 2004. A key to species of Stantonia from Vietnam, China, Russia, and Japan is provided. PMID:29362527

  18. Quantitative Characterization of Molecular Similarity Spaces: Tools for Computational Toxicology

    DTIC Science & Technology

    2000-01-20

    numbers for hydrogen-filled molecular structure, hydrogen-suppressed molecular structure, and van der Waals volume. Van der Waals...relative covalent radii Geometrical Vw van der Waals volume 3DW 3-D Wiener number for the hydrogen-suppressed geometric distance matrix...molecular structure, and van der Waals volume. Van der Waals volume, Vw (Bondi 1964). was calculated using Sybyl 6.1 from Tripos As- sociates. Inc

  19. Physical Protection: the State of the Art

    DTIC Science & Technology

    2005-02-01

    fundamentele mechanisme van adsorptie van water beschrijft; dit is ingewikkeld en kost veel tijd ; een tweede benadering is het opstellen van een eenvoudig...gasscheidingsmethoden, bij voorkeur regeneratief, zijn zeer wenselijk vanwege de logistieke voordelen en de gegarandeerde langere operatie tijd . P(T)SA is meer...in de loop van de tijd ) met vrij simpele middelen en technieken sterk worden verbeterd. Deze technieken, zoals micro-encapsulatie en toevoeging van

  20. Thickened boundary layer theory for air film drag reduction on a van body surface

    NASA Astrophysics Data System (ADS)

    Xie, Xiaopeng; Cao, Lifeng; Huang, Heng

    2018-05-01

    To elucidate drag reduction mechanism on a van body surface under air film condition, a thickened boundary layer theory was proposed and a frictional resistance calculation model of the van body surface was established. The frictional resistance on the van body surface was calculated with different parameters of air film thickness. In addition, the frictional resistance of the van body surface under the air film condition was analyzed by computational fluid dynamics (CFD) simulation and different air film states that influenced the friction resistance on the van body surface were discussed. As supported by the CFD simulation results, the thickened boundary layer theory may provide reference for practical application of air film drag reduction on a van body surface.

  1. Social Errors in Four Cultures: Evidence about Universal Forms of Social Relations.

    ERIC Educational Resources Information Center

    Fiske, Alan Page

    1993-01-01

    To test the cross-cultural generality of relational-models theory, 4 studies with 70 adults examined social errors of substitution of persons for Bengali, Korean, Chinese, and Vai (Liberia and Sierra Leone) subjects. In all four cultures, people tend to substitute someone with whom they have the same basic relationship. (SLD)

  2. The Funding of Library and Information Services in West Africa.

    ERIC Educational Resources Information Center

    Boadi, B. Y.; Havard-Williams, P.

    1984-01-01

    Results of a study of the funding patterns of 148 library and information services over a three-year period (1976/77-1978/79) in the Anglophone countries of The Gambia, Ghana, Liberia, Nigeria, and the Sierra Leone reveal that national governments are the main sources of income. Six references are included. (EJS)

  3. Factors Associated with Interest in Science of West African Students in Washington, D.C.

    ERIC Educational Resources Information Center

    Onwere, Godfrey O.

    1980-01-01

    Describes a study designed to identify factors which students from Gambia, Ghana, Liberia, Nigeria, and Sierra Leone associated with precollege interest in science and factors which influenced or contributed to the choice of a science major or dissuaded students from entering a scientific field. (Author/GC)

  4. Library Literature in English-Speaking West Africa; Its Achievements, Problems and Prospects.

    ERIC Educational Resources Information Center

    Nyarko, K.

    This report surveys the development of librarianship in West Africa since 1954, focusing primarily on the production of professional library literature in Gambia, Ghana, Nigeria, Sierra Leone, and Liberia, the five countries which constitute the sub-region of English-speaking West Africa. An overview of library developments is presented, and three…

  5. 77 FR 16795 - Approval and Promulgation of Implementation Plans and Operating Permits Program; Commonwealth of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    .... SUMMARY: EPA is proposing to approve revisions to the Puerto Rico Regulations for the Control of Atmospheric Pollution, submitted to EPA by the Puerto Rico Environmental Quality Board (PREQB) on July 13... de Leon Avenue, Stop 22, Santurce, Puerto Rico 00909. FOR FURTHER INFORMATION CONTACT: Kirk J. Wieber...

  6. The Social Context of Mathematics Teaching. Perspectives 37.

    ERIC Educational Resources Information Center

    Ernest, Paul, Ed.

    This publication contains seven papers by the staff of the University of Exeter School of Education and by invited outside contributors. The focus is on issues that consider the social context of mathematics. The papers are: (1) "Images of Mathematics" (Leone Burton); (2) "Of Course You Could be an Engineer, Dear, but Wouldn't You…

  7. Opening the American Mind: Race, Ethnicity, and Gender in Higher Education.

    ERIC Educational Resources Information Center

    Sill, Geoffrey M., Ed.; And Others

    This book presents a collection of essays addressing the theoretical, institutional, and disciplinary problems created by the diversification of American culture. The 13 essays have the following titles and authors: (1) "The De-Europeanization of American Culture" (Leon Botstein); (2) "Cult-Lit: Hirsch, Literacy, and 'The National Culture'"…

  8. A Neo-Piagetian Analysis of Communication Performance in Young Children.

    ERIC Educational Resources Information Center

    Foorman, Barbara R.

    This exploratory study was conducted to interpret age and individual differences in 48 kindergarteners' and second graders' performance on a referential communication task in light of the Pascual-Leone Theory of Constructive Operations, a neo-Piagetian theory of cognitive development. Stimulus materials were black and white photographs of dogs,…

  9. Principals' Role and Public Primary Schools' Effectiveness in Four Latin American Cities

    ERIC Educational Resources Information Center

    Anderson, Joan B.

    2008-01-01

    This article examines the effectiveness of observable and quantifiable traits in and approaches of school principals in enhancing student achievement. Data were gathered on 2,048 fourth-grade students in 96 public primary schools in Leon, Mexico; Belo Horizonte, Brazil; Buenos Aires, Argentina; and Santiago, Chile. The UNESCO/ORELAC (United…

  10. The Philosopher, the Rabbi, and the Rhetorician

    ERIC Educational Resources Information Center

    Handelman, Susan

    2010-01-01

    The author explores the topic of Jewish rhetorics by examining how particular Jewish thinkers have conceptualized the ethical relation between self and other. She draws particular attention to the tacit rhetorical methodology at work in the teachings of Rabbi Yehouda Leon Askenazi. She shows that he distinguished himself from the more well-known…

  11. Correspondence between Single versus Daily Preference Assessment Outcomes and Reinforcer Efficacy under Progressive-Ratio Schedules

    ERIC Educational Resources Information Center

    Call, Nathan A.; Trosclair-Lasserre, Nicole M.; Findley, Addie J.; Reavis, Andrea R.; Shillingsburg, M. Alice

    2012-01-01

    Research has suggested that a daily multiple-stimulus-without-replacement (MSWO) preference assessment may be more sensitive to changes in preference than other assessment formats, thereby resulting in greater correspondence with reinforcer efficacy over time (DeLeon et al., 2001). However, most prior studies have measured reinforcer efficacy…

  12. Evaluating the Influence of Postsession Reinforcement on Choice of Reinforcers

    ERIC Educational Resources Information Center

    Kodak, Tiffany; Lerman, Dorothea C.; Call, Nathan

    2007-01-01

    Factors that influence reinforcer choice have been examined in a number of applied studies (e.g., Neef, Mace, Shea, & Shade, 1992; Shore, Iwata, DeLeon, Kahng, & Smith, 1997; Tustin, 1994). However, no applied studies have evaluated the effects of postsession reinforcement on choice between concurrently available reinforcers, even though basic…

  13. ARC-2010-ACD10-0052-220

    NASA Image and Video Library

    2010-03-20

    For Inspiration and Recognition of Science and Technology; FIRST Robotics Competition 2010 Silicon Valley Regional held at San Jose State University, San Jose, California The Wild Hats of Woodside H.S. & Carlmont H. S. & Sequoia H.S & Sequoia H.S. District, CA Team 100 with Mark Leon, NASA Ames Reseach Center (in trademark blue hair)

  14. Sterling C. Robertson Dam and Limestone Lake on the Navasota River, Texas (Leon, Limestone and Robertson Counties).

    DTIC Science & Technology

    1976-04-01

    Plicrocysti s sp. Synechococcus sp. Order Chamaesi phonal es Chamaesiphon sp. Order Hormogonal1es Anabaena sp. Anabaenopsis sp. Arthrospira sp...Sc-ytonerrn sp. Stig m rp. Spirulina sp. Kingdom Protista Phylum Euglenophyta (Euglenas) Order Euglenales Eugena sp. Phacus sp. Trache omonas sp

  15. 77 FR 11586 - Certain Toner Cartridges and Components Thereof

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-27

    ...., Ltd., d/b/a Huebon Co., Limited, d/b/a Ink-Tank, 3/F, No. 1 Industrial Building, Pingdong 2 Road....V., Avenida del Parque 1175, Monterrey Technology Park, Cienega de Flores, Nuevo Leon, Mexico 65550...., 7611 Green Meadows Drive, Lewis Center, OH 43035. Discount Office Items, Inc., 302 Industrial Drive...

  16. Defense.gov - Special Report: Travels with Panetta - July-August 2012

    Science.gov Websites

    Today in DOD About DOD Leaders Biographies Organization Mission History Frequently Asked Questions Leon E. Panetta and Israeli Prime Minister Benjamin Netanyahu. Story U.S., Israeli Leaders United with Jordanian King Abdullah in Amman, Jordan More Photo Essays Panetta Meets with Israeli Leaders in

  17. Defense.gov Special Report: Travels with Panetta - March 2012

    Science.gov Websites

    DOD About DOD Leaders Biographies Organization Mission History Frequently Asked Questions Available Secretary Leon E. Panetta said U.S., Afghan and coalition leaders are unified in achieving the mission of Panetta Visits Afghanistan, Meets Afghan Leaders, U.S. Troops Panetta Visits Afghanistan, Meets Afghan

  18. History of Higher Education, 1995.

    ERIC Educational Resources Information Center

    Geiger, Robert L., Ed.

    1995-01-01

    This annual compilation presents four papers on different aspects of the history of higher education in Europe and the United States. The first paper is "The Rights of Man and the Rites of Youth: Fraternity and Riot at Eighteenth Century Harvard" by Leon Jackson. This paper argues that the lines of division in the student body at…

  19. Amblyomma imitator Ticks as Vectors of Rickettsia rickettsii, Mexico

    PubMed Central

    Oliveira, Karla A.; Pinter, Adriano; Medina-Sanchez, Aaron; Boppana, Venkata D.; Wikel, Stephen K.; Saito, Tais B.; Shelite, Thomas; Blanton, Lucas; Popov, Vsevolod; Teel, Pete D.; Walker, David H.; Galvao, Marcio A.M.; Mafra, Claudio

    2010-01-01

    Real-time PCR of Amblyomma imitator tick egg masses obtained in Nuevo Leon State, Mexico, identified a Rickettsia species. Sequence analyses of 17-kD common antigen and outer membrane protein A and B gene fragments showed to it to be R. rickettsii, which suggested a potential new vector for this bacterium. PMID:20678325

  20. Social vulnerability and Ebola virus disease in rural Liberia

    Treesearch

    John A. Stanturf; Scott L. Goodrick; Melvin L. Warren; Susan Charnley; Christie M. Stegall

    2015-01-01

    The Ebola virus disease (EVD) epidemic that has stricken thousands of people in the three West African countries of Liberia, Sierra Leone, and Guinea highlights the lack of adaptive capacity in post-conflict countries. The scarcity of health services in particular renders these populations vulnerable to multiple interacting stressors including food insecurity, climate...

  1. Defeating Mexico’s Drug Trafficking Organizations: The Range of Military Operations in Mexico

    DTIC Science & Technology

    2012-06-08

    Nuevo Leon, Chihuahua, Baja California, and Sinaloa (see figure 2) with 60 percent of all killings in 2008 reported in three cities: Tijuana, Baja...California; Culiacan, Sinaloa ; and Ciudad Juarez, Chihuahua.2 Ciudad Juarez had the highest rate of DTO related deaths; this is significant for the U.S...

  2. Proliferation of Small Arms and Light Weapons in West Africa: Implications for Subregional Security

    DTIC Science & Technology

    2007-06-15

    recruits for violent or rebel organizations. He employs the analogy of Sierra Leone where despite disarmament, the unemployed youths 21 still...infrastructure and the people’s corrupted psychic will take along time to be reoriented. More so, the future of the nation will continue to be

  3. Magnetotelluric studies at the Cerro Prieto geothermal field

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Goubau, W.M.; Goldstein, N.E.; Clarke, J.

    During three years of magnetotelluric surveying, data were acquired at 26 sites distributed over 190 km/sup 2/ around the production area. A relatively well-defined strike of N27W +- 1.5/sup 0/ (magnetic) was established. The simple model shown suggests a lateral discontinuity in the vicinity of Nueva Leon.

  4. TRANSGENERATIONAL EFFECTS OF DEHP IN THE MALE RAT

    EPA Science Inventory

    Abstract

    TITLE: Transgenerational Effects of Di(2-ethylhexyl) Phthalate in the Male Rat. AUTHORS (ALL): Gray, Leon Earl1; Barlow, Norman J2; Furr, Johnathan R1; Brock, John 3; Silva, Manori J3; Barr, Dana B3; Ostby, Joseph S1

    SPONSOR NAME:

    INSTITUTIONS (AL...

  5. Biography as an Art: Selected Criticism 1560-1960.

    ERIC Educational Resources Information Center

    Clifford, James L., Ed.

    Forty-seven essays from five centuries of writings on biography are contained in this book. Selections are arranged under the following headings: "Before 1700" (9 selections), "The Eighteenth Century" (5), "The Nineteenth Century" (11), "Early Twentieth Century" (14), and "Mid-Twentieth Century" (8). Authors range from Francis Bacon to Leon Edel.…

  6. Defense.gov Special Report: DoD Helps Fight Ebola in West Africa

    Science.gov Websites

    Assistance at a Glance Health Care Training Infographic #1 Ebola Treatment Units/Monrovian Medical Unit , Liberia and Sierra Leone. Story Medical Countermeasures Help Ebola Crisis Since 2003, the Defense Threat Reduction Agency has invested more than $300 million to develop medical countermeasures against hemorrhagic

  7. Anemia, micronutrient deficiencies, and malaria in children and women in Sierra Leone prior to the Ebola outbreak

    USDA-ARS?s Scientific Manuscript database

    To identify the factors associated with anemia and to document the severity of micronutrient deficiencies, malaria and inflammation, a nationally representative cross-sectional survey was conducted. A three-stage sampling procedure was used to randomly select children <5 years of age and adult women...

  8. The Revolutionary United Front and Child Soldiers during Sierra Leone’s Civil War

    DTIC Science & Technology

    2015-06-12

    Armed Forces served as an ex post facto force during the internal conflict period between the APC and SLPP jockeying for the position of Prime Minister...civil war. Chapter 3, Research Methodology, addresses biases and the reliability of the study regarding the thesis findings. Chapter 4, Analysis

  9. Sierra Leone's Former Child Soldiers: A Longitudinal Study of Risk, Protective Factors, and Mental Health

    ERIC Educational Resources Information Center

    Betancourt, Theresa S.; Brennan, Robert T.; Rubin-Smith, Julia; Fitzmaurice, Garrett M.; Gilman, Stephen E.

    2010-01-01

    Objective: To investigate the longitudinal course of internalizing and externalizing problems and adaptive/prosocial behaviors among Sierra Leonean former child soldiers and whether postconflict factors contribute to adverse or resilient mental health outcomes. Method: Male and female former child soldiers (N = 260, aged 10 to 17 years at…

  10. Nonmonotonic dose response curves (NMDRCs) are common after Estrogen or Androgen signaling pathway disruption. Fact or Falderal?##

    EPA Science Inventory

    Nonmonotonic dose response curves (NMDRCs) are common after Estrogen or Androgen signaling pathway disruption. Fact or Falderal? Leon Earl Gray Jr, USEPA, ORD, NHEERL, TAD, RTB. RTP, NC, USA The shape of the dose response curve in the low dose region has been debated since th...

  11. Defense.gov Special Report: Veterans Day 2011

    Science.gov Websites

    Department of Defense Submit Search Veterans Day 2011 - Honoring our Nation's Veterans - 11.11.11 Sept. 26 deserve our country's gratitude - not just on Veterans Day, but every day." Defense Secretary Leon E . Story Leaders Participate in Vets Day Events WASHINGTON, Nov. 11, 2011 - Today's Arlington National

  12. "Are We All Together?"

    ERIC Educational Resources Information Center

    von Kotze, Astrid

    2005-01-01

    In 2002, Sierra Leone, a small country on the west coast of Africa, emerged from a brutal civil war that had lasted 11 years. It claimed 20,000 lives and displaced well over one million people, who either fled into neighbouring Guinea or Liberia or survived in the forests, swamps, and mountains. The devastation caused by rebel campaigns of…

  13. Peace Corps Water/Sanitation Case Studies and Analyses. Appropriate Technologies for Development. Case Study CS-4.

    ERIC Educational Resources Information Center

    Talbert, Diana E., Comp.

    This document provides an overview of Peace Corps water and sanitation activities, five case studies (Thailand, Yemen, Paraguay, Sierra Leone, and Togo), programming guidelines, and training information. Each case study includes: (1) background information on the country's geography, population, and economics; (2) information on the country's…

  14. Ebola: is the response justified?

    PubMed Central

    Lewis, Hannah; Chaudry, Aisha; Ndow, Gibril; Crossey, Mary ME; Garside, Debbie; Njie, Ramou; Taylor-Robinson, Simon D

    2015-01-01

    Ebola virus disease is a viral hemorrhagic fever, first discovered in 1976 in Sudan, where the outbreak infected over 284 people with a 53% case fatality ratio. There have been 34 further epidemics, the current major incident in West Africa having recorded more cases and deaths than all previous outbreaks combined. To date there have been over 27, 000 confirmed, probable and suspected cases and 11,000 reported deaths in Liberia, Guinea and Sierra Leone. With total funding and pledges to help control the outbreak amounting to more than US$2.4billion, many question how the disease has continued to spread in Sierra Leone and Guinea Conakry, and whether the response to the outbreak has been justified. This article aims to analyze the effectiveness of the responses to the outbreak in terms of economic, social, cultural and, to an extent, political impact. We argue that the response has been justified due to the awareness raised, the infrastructure and staffing improvements, the success in receiving financial aid and the minimal spread to other countries outside the main transmission zone. Despite this, some failures in communication and a slow early response were noted. PMID:26740851

  15. [Validation of a knowledge-questionnaire about asthma applied to teachers of elementary school of Monterrey, Mexico].

    PubMed

    González Diaz, Sandra Nora; Cruz, Alfredo Arias; González González, Arya Yannel; Félix Berumen, José Alfredo; Weinmann, Alejandra Macías

    2010-01-01

    asthma is one of the most common chronic childhood diseases; is increasing in prevalence and an important cause of school absenteeism. Previous studies have failed to evaluate knowledge about asthma among elementary school teachers worldwide because of the lack of validated questionnaires. to validate a questionnaire about asthma knowledge for elementary school teachers in Monterrey, Nuevo Leon. an observational, cross sectional, descriptive study, from February to December 2004, by applying a questionnaire to a group of elementary school teachers in Monterrey, Nuevo Leon. The questionnaire is a translation and adaptation to the questionnaire of 13 questions used to assess the knowledge about asthma among parents, according to the National Asthma Education Program of US. a total of 179 questionnaires were applied, in which 6 of the 13 questions were answered correctly by more than 90% of the teachers. The internal consistency reliability was adequate with a Cronbach a coefficient of 0.75. in order to obtain reliable data using questionnaires, these must undergo a validation process. Our questionnaire got validation because of the reliability shown according to the internal consistency analysis.

  16. The Effectiveness of International Non-Governmental Organizations' Response Operations during Public Health Emergency: Lessons Learned from the 2014 Ebola Outbreak in Sierra Leone.

    PubMed

    Shin, Yoon Ah; Yeo, Jungwon; Jung, Kyujin

    2018-04-01

    International Nongovernmental Organizations (INGOs) have played critical roles in improving the quality of primary health care in ordinary time and, indeed, responding to epidemic crises in developing countries. Due to a lack of empirical research for effectiveness of their responding activities, the legitimacy and accountability of nonprofits' engagement in the health crisis as a critical responder is doubted. This paper aims to examine the effectiveness of INGOs in a context of managing a fatal epidemic outbreak of Ebola in Sierra Leone during May-November, 2014; building healthcare infrastructures, providing medical supplies, educating local residents, and training response staffs. The analysis results show that development of healthcare infrastructures and provision of medical supplies have been significantly effective in terms of decreasing the severity of the crisis in chiefdoms. The findings imply that policy tools, which allow INGOs to enter to the field in a timely manner, can improve the effectiveness of INGOs' responses in current and future epidemic outbreaks in developing countries where people suffer from a lack of health infrastructures.

  17. Using evidence to strengthen accountability for health financing in Sierra Leone.

    PubMed

    Lebbie, Sowo A; Le Voir, Rosanna; Tom-Kargbo, Joanna; Yilla, Mohamed Drissa; Kamara, Abu Bakarr; Nam, Sara L

    2016-12-01

    In 2012, the government of Sierra Leone cut the national budget allocation to the health sector. Civil society organizations planned a nationwide health budget advocacy campaign, coinciding with the 2012 general elections, to hold future leaders to account on financing for women's and children's health. As part of the campaign, Evidence for Action produced district health budget tracking scorecards. The scorecards presented Ministry of Finance data on the allocation and disbursement of health funds in each district. The data were communicated using simple, non-technical language so that citizens could understand the key messages and take action. A total of 5600 scorecards were shared at district electoral forums attended by political candidates, community members, and health activists. Since the election, the proportion of the total government budget allocated to health increased from 7.4% in 2012 to 11.2% in 2014. However, transforming politicians' commitments and pledges into implementation has been challenging, confirming that accountability is a long-term process. Copyright © 2016 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

  18. Adolescent fertility management: the Sierra Leone experience.

    PubMed

    Lamin, M M; Singleton, A

    1982-01-01

    Because of growing concerns for the problems of adolescent fertility, a training program in Adolescent Fertility Management was conducted in Sierra Leone in 1981. The program was designed to actuate the interdisciplinary energies necessary for exploring the depth of the problem and to develop strategies for possible solutions. 2 program activities were conducted: a Former Participant Conference, which resulted in the development of a draft of a country-wide program; and a 2-week training workshop. In order to create public awareness, the participants presented an original drama, a synopsis of which is provided. Solutions to the problems of adolescent fertility must address not only the availability and use of contraceptives, but also a reorientation of the attitudes of parents on sex education. The practice of expelling pregnant adolescents from educational institutions only serves to compound the problems. A list of the topics covered during the workshops is provided, as are a summary of the conclusions and subsequent recommendations. Participants voted to form a national organization whose main objective is the reduction of teenage pregnancy by at least 12% within a 12 month period through the creation of a national awareness campaign.

  19. The Effectiveness of International Non-Governmental Organizations’ Response Operations during Public Health Emergency: Lessons Learned from the 2014 Ebola Outbreak in Sierra Leone

    PubMed Central

    Shin, Yoon Ah; Yeo, Jungwon

    2018-01-01

    International Nongovernmental Organizations (INGOs) have played critical roles in improving the quality of primary health care in ordinary time and, indeed, responding to epidemic crises in developing countries. Due to a lack of empirical research for effectiveness of their responding activities, the legitimacy and accountability of nonprofits’ engagement in the health crisis as a critical responder is doubted. This paper aims to examine the effectiveness of INGOs in a context of managing a fatal epidemic outbreak of Ebola in Sierra Leone during May–November, 2014; building healthcare infrastructures, providing medical supplies, educating local residents, and training response staffs. The analysis results show that development of healthcare infrastructures and provision of medical supplies have been significantly effective in terms of decreasing the severity of the crisis in chiefdoms. The findings imply that policy tools, which allow INGOs to enter to the field in a timely manner, can improve the effectiveness of INGOs’ responses in current and future epidemic outbreaks in developing countries where people suffer from a lack of health infrastructures. PMID:29614756

  20. Detection and Partial Characterization of Simian Immunodeficiency Virus SIVsm Strains from Bush Meat Samples from Rural Sierra Leone

    PubMed Central

    Apetrei, Cristian; Metzger, Michael J.; Richardson, David; Ling, Binhua; Telfer, Paul T.; Reed, Patricia; Robertson, David L.; Marx, Preston A.

    2005-01-01

    Human immunodeficiency virus type 2 (HIV-2) originated from simian immunodeficiency viruses (SIVs) that naturally infect sooty mangabeys (SMs; Cercocebus atys). In order to further investigate the relationship between HIV-2 and SIVsm, the SIV specific to the SM, we characterized seven new SIVsm strains from SMs sold in Sierra Leone markets as bush meat. The gag, pol, and env sequences showed that, while the viruses of all seven SMs belonged to the SIVsm-HIV-2 lineage, they were highly divergent viruses, in spite of the fact that most of the samples originated from the same geographical region. They clustered in three lineages, two of which have been previously reported. Two of the new SIVsm strains clustered differently in gag and env phylogenetic trees, suggesting SIVsm recombination that had occurred in the past. In spite of the fact that our study doubles the number of known SIVsm strains from wild SMs, none of the simian strains were close to the groups in which HIV-2 was epidemic (groups A and B). PMID:15681464

Some links on this page may take you to non-federal websites. Their policies may differ from this site.
Top