Chaparral Shrub Hydraulic Traits, Size, and Life History Types Relate to Species Mortality during California’s Historic Drought of 2014

PubMed Central

MacKinnon, Evan D.; Dario, Hannah L.; Jacobsen, Anna L.; Pratt, R. Brandon; Davis, Stephen D.

2016-01-01

Chaparral is the most abundant vegetation type in California and current climate change models predict more frequent and severe droughts that could impact plant community structure. Understanding the factors related to species-specific drought mortality is essential to predict such changes. We predicted that life history type, hydraulic traits, and plant size would be related to the ability of species to survive drought. We evaluated the impact of these factors in a mature chaparral stand during the drought of 2014, which has been reported as the most severe in California in the last 1,200 years. We measured tissue water potential, native xylem specific conductivity, leaf specific conductivity, percentage loss in conductivity, and chlorophyll fluorescence for 11 species in February 2014, which was exceptionally dry following protracted drought. Mortality among the 11 dominant species ranged from 0 to 93%. Total stand density was reduced 63.4% and relative dominance of species shifted after the drought. Mortality was negatively correlated with water potential, native xylem specific conductivity, and chlorophyll fluorescence, but not with percent loss in hydraulic conductivity and leaf specific conductivity. The model that best explained mortality included species and plant size as main factors and indicated that larger plants had greater survival for 2 of the species. In general, species with greater resistance to water-stress induced cavitation showed greater mortality levels. Despite adult resprouters typically being more vulnerable to cavitation, results suggest that their more extensive root systems enable them to better access soil moisture and avoid harmful levels of dehydration. These results are consistent with the hypothesis that short-term high intensity droughts have the strongest effect on mature plants of shallow-rooted dehydration tolerant species, whereas deep-rooted dehydration avoiding species fare better in the short-term. Severe droughts can drive changes in chaparral structure as a result of the differential mortality among species. PMID:27391489

Chaparral Shrub Hydraulic Traits, Size, and Life History Types Relate to Species Mortality during California's Historic Drought of 2014.

PubMed

Venturas, Martin D; MacKinnon, Evan D; Dario, Hannah L; Jacobsen, Anna L; Pratt, R Brandon; Davis, Stephen D

2016-01-01

Chaparral is the most abundant vegetation type in California and current climate change models predict more frequent and severe droughts that could impact plant community structure. Understanding the factors related to species-specific drought mortality is essential to predict such changes. We predicted that life history type, hydraulic traits, and plant size would be related to the ability of species to survive drought. We evaluated the impact of these factors in a mature chaparral stand during the drought of 2014, which has been reported as the most severe in California in the last 1,200 years. We measured tissue water potential, native xylem specific conductivity, leaf specific conductivity, percentage loss in conductivity, and chlorophyll fluorescence for 11 species in February 2014, which was exceptionally dry following protracted drought. Mortality among the 11 dominant species ranged from 0 to 93%. Total stand density was reduced 63.4% and relative dominance of species shifted after the drought. Mortality was negatively correlated with water potential, native xylem specific conductivity, and chlorophyll fluorescence, but not with percent loss in hydraulic conductivity and leaf specific conductivity. The model that best explained mortality included species and plant size as main factors and indicated that larger plants had greater survival for 2 of the species. In general, species with greater resistance to water-stress induced cavitation showed greater mortality levels. Despite adult resprouters typically being more vulnerable to cavitation, results suggest that their more extensive root systems enable them to better access soil moisture and avoid harmful levels of dehydration. These results are consistent with the hypothesis that short-term high intensity droughts have the strongest effect on mature plants of shallow-rooted dehydration tolerant species, whereas deep-rooted dehydration avoiding species fare better in the short-term. Severe droughts can drive changes in chaparral structure as a result of the differential mortality among species.

Survival Analysis Of The Modernized Retirement System For The United States Marine Corps

DTIC Science & Technology

2016-03-01

November 2015 to begin as early as 2018. This online survey will assist the Marine Corps in determining the retention impacts of the new retirement...thesis determines if the Modernized Retirement System is likely to affect manpower levels. A survey was conducted within the active component of the U.S...2016. Specifically, this thesis determines if the Modernized Retirement System is likely to affect manpower levels. A survey was conducted within

Increasing atmospheric [CO2] from glacial through future levels affects drought tolerance via impacts on leaves, xylem and their integrated function

PubMed Central

Medeiros, Juliana S.; Ward, Joy K.

2013-01-01

Summary Changes in atmospheric carbon dioxide concentration ([CO2]) affect plant carbon/water trade-offs, with implications for drought tolerance. Leaf-level studies often indicate that drought tolerance may increase with rising [CO2], but integrated leaf and xylem responses are not well understood in this respect. In addition, the influence of low [CO2] of the last glacial period on drought tolerance and xylem properties is not well understood.We investigated the interactive effects of a broad range of [CO2] and plant water potentials on leaf function, xylem structure and function and the integration of leaf and xylem function in Phaseolus vulgaris.Elevated [CO2] decreased vessel implosion strength, reduced conduit specific hydraulic conductance, and compromised leaf specific xylem hydraulic conductance under moderate drought. By contrast, at glacial [CO2], transpiration was maintained under moderate drought via greater conduit specific and leaf specific hydraulic conductance in association with increased vessel implosion strength.Our study involving the integration of leaf and xylem responses suggests that increasing [CO2] does not improve drought tolerance. We show that under glacial conditions changes in leaf and xylem properties could increase drought tolerance, while under future conditions greater productivity may only occur when higher water use can be accommodated. PMID:23668237

Evaluation of Course-Specific Self-Efficacy Assessment Methods.

ERIC Educational Resources Information Center

Bong, Mimi

A study was conducted to compare three methods of assessing course-level self-efficacy beliefs within a multitrait multimethod (MTMM) framework. The methods involved: (1) successfully performing a number of domain-related tasks; (2) obtaining specific letter grades in the course; and (3) successfully performing generic academic tasks in the…

Expressed Sexual Assault Legal Context and Victim Culpability Attributions

ERIC Educational Resources Information Center

Miller, Audrey K.; Markman, Keith D.; Amacker, Amanda M.; Menaker, Tasha A.

2012-01-01

Legal scholars have argued that laws have an "expressive function", specifically that sexual assault laws may convey social-level messages that victims are culpable for crimes against them. In a university sample, we conducted the first experimental test of legal scholars' proposal, hypothesizing that legal messages--specifically their…

Ostracod-inferred conductivity transfer function and its utility in palaeo-conductivity reconstruction in Tibetan Lakes

NASA Astrophysics Data System (ADS)

Peng, P.; Zhu, L.; Guo, Y.; Wang, J.; Fürstenberg, S.; Ju, J.; Wang, Y.; Frenzel, P.

2016-12-01

Ostracod, was used as a sensitive monitor in palaeo-environmental change research. Ostracod transfer function was developing as a quantitate indicator in palaeo-limnology research. Plenty of lakes scattered on the Tibetan Plateau supplied sediments for analyzing indexes of environment in past climate change research. This application was research on samples of sub-fossil ostracod and its habitat condition, including water sample and water parameters, to produce a database for a forward transfer function based on gradient analyses. This transfer function was used for environment reconstruction of Tibetan lakes to preview past climate changes. In our research, twelve species belonging to ten genus were documented from 114 studied samples in 34 lakes. This research illustrated a specific conductivity gradient gradually increased by L.sinensis-L.dorsotuberosa-C.xizangensis, L.dorsotuberosa-L.inopinata and L.inopinata to indicate fresh-lightly brackish, brackish, brine water condition, respectively. Gradient analysis revealed that specific conductivity was the most important variable drove the distribution of sub-fossil Ostracods. A specific conductivity transfer function using a weighted averaging partial least squares (WA-PLS) model was set up to reconstruct palaeo-specific conductivity. The model presented a good correlation of measured and estimated specific conductivity (R2=0.67), a relative low root mean squared error of prediction (RMSEP=0.47). Multi-proxies, including ostracod assemblages, ostracod-inferred lake level and specific conductivity, mean grain size, total organic carbon and total inorganic carbon of sediment from core of Tibetan Lakes, inferred the palaeo-climate change history of the research area. The environmental change probably was an adaption to the weakening activities of India monsoon since mid-Holocene inferred from the comparable climatic change records from the Tibetan Plateau and relative monsoonal areas.

Proposed Hydrodynamic Model Improves Resolution of Species-Specific Responses to Drought and Disturbance

NASA Astrophysics Data System (ADS)

Matheny, A. M.; Bohrer, G.; Fiorella, R.; Mirfenderesgi, G.

2015-12-01

Plant functional types in land surface models (LSMs) are broadly defined, and often represent species with different physiologies within the same category. For example, trees of opposing hydraulic strategies and traits are commonly grouped together, as is the case of red oak and red maple. As a result, LSMs generate typical patterns of errors in predictions of transpiration and production. We studied sap flux, stem water storage, stomatal conductance, photosynthesis, rooting depth, and bole growth of these species at disturbed and undisturbed field sites in Michigan. Species-specific differences significantly impact temporal patterns of stomatal conductance and overall transpiration responses to both drought and disturbance. During drought, maples relied heavily on stem-stored water, while oaks did not. After disturbance, oaks increased stomatal conductance while maple conductance declined. Isotopic analysis of xylem water revealed that oak roots can access a deep groundwater source, which maple roots cannot. This deep rooting strategy permits transpiration and growth to continue in oaks during periods of water limitation, even when maples cease transpiration. Using 16 years of bole growth data, we show that maple growth is strongly correlated with mean annual precipitation, yet oak growth is not. We propose a framework to incorporate these species-specific differences into LSMs using the Finite-Element Tree-Crown Hydrodynamics model version 2 (FETCH2) that resolves the fast dynamics and diurnal hysteresis of stomatal conductance at the tree level. FETCH2 uses atmospheric and biological forcings from the LSM, simulates water movement through trees as flow through a system of porous media conduits, and calculates realistic hydraulic restrictions to stomatal conductance. This model replaces the current, non-physical link which empirically connects soil moisture to stomatal conductance in LSMs. FETCH2 resolved transpiration is then easily scaled to the plot level using remote sensing data. By incorporating species-specific constraints on water flux into predictions of transpiration, growth, and mortality, we can improve simulations of the surface energy budget and global carbon and water balances.

Sesame allergy: role of specific IgE and skin-prick testing in predicting food challenge results.

PubMed

Permaul, Perdita; Stutius, Lisa M; Sheehan, William J; Rangsithienchai, Pitud; Walter, Jolan E; Twarog, Frank J; Young, Michael C; Scott, Jordan E; Schneider, Lynda C; Phipatanakul, Wanda

2009-01-01

There are conflicting data regarding the diagnostic value of sesame-specific IgE and sesame skin test. Currently, there are no established thresholds that predict clinical reactivity. We examined the correlation of sesame ImmunoCAP and skin-prick test (SPT) results with oral challenge outcomes in children suspected of having a sesame food allergy. We conducted a retrospective chart review of children, aged 2-12 years, receiving a sesame ImmunoCAP level, SPT, and food challenge from January 2004 to August 2008 at Children's Hospital Boston and affiliated allergy clinics. Food challenges were conducted in cases of questionable clinical history or a negative ImmunoCAP and/or negative SPT despite a convincing history. Thirty-three oral sesame challenges were conducted. Of the 33 challenges performed, 21% (n = 7) failed and 79% (n = 26) passed. A sesame-specific IgE level of > or = 7 kU(A)/L showed specificity of >90%. An SPT wheal size of > or = 6 mm showed specificity of >90%. Receiver operator characteristic (ROC) curve analysis for sesame-specific IgE revealed an area under the curve (AUC) of 0.56. ROC curve analysis for SPT wheal size revealed an AUC of 0.67. To our knowledge, this study represents the largest number of sesame challenges performed to evaluate the diagnostic value of both sesame-specific IgE and SPT. Based on our sample, both tests are not good predictors of true sesame allergy as determined by an oral challenge. We were unable to establish a threshold with a 95% positive predictive value for both sesame-specific IgE and SPT.

Efficacy Profiles of Psychopharmacology: Divalproex Sodium in Conduct Disorder

ERIC Educational Resources Information Center

Khanzode, Leena A.; Saxena, Kirti; Kraemer, Helena; Chang, Kiki; Steiner, Hans

2006-01-01

Little is known about how deeply medication treatment penetrates different levels of the mind/brain system. Psychopathology consists of relatively simple constructs (e.g., anger, irritability), or complex ones (e.g., responsibility). This study examines the efficacy of a specific compound, divalproex sodium (DVPX), on the various levels of…

Library Users' Service Desires: A LibQUAL+ Study

ERIC Educational Resources Information Center

Thompson, Bruce; Kyrillidou, Martha; Cook, Colleen

2008-01-01

The present study was conducted to explore library users' desired service quality levels on the twenty-two core LibQUAL+ items. Specifically, we explored similarities and differences in users' desired library service quality levels across user groups (i.e., undergraduate students, graduate students, and faculty), across geographic locations (i.e.,…

Specific conductance, water temperature, and water level data, San Francisco Bay, California, water year 1998

USGS Publications Warehouse

Buchanan, Paul A.

1999-01-01

Specific conductance and water temperature data are continuously recorded at four sites in San Francisco Bay, California: San Pablo Strait at Point San Pablo, Central San Francisco Bay at Presidio Military Reservation, Pier 24 at Bay Bridge, and South San Francisco Bay at San Mateo Bridge near Foster City (Figure 1). Water level data are recorded only at San Pablo Strait at Point San Pablo. These data were recorded by the Department of Water Resources (DWR) before 1988, by the US Geological Survey (USGS) National Research Program from 1988 to 1989, and by the USGS-DWR cooperative program since 1990. This article presents time-series plots of data from the four sites in San Francisco Bay during water year 1998 (1 October 1997 through 30 September 1998).

Level of Agricultural Education Advisory Council Implementation in Idaho Secondary Agricultural Education Programs

ERIC Educational Resources Information Center

Masser, Douglas T.; Falk, Jeremy M.; Foster, Daniel D.

2014-01-01

Advisory councils are community-specific and are major components of agricultural education programs. This descriptive study was conducted to further strengthen what is known about advisory councils and provide a basis for continued improvement in local programs. The specific purpose of the research study was to describe how Idaho agricultural…

Source-specific workplace social support and high-sensitivity C-reactive protein levels among Japanese workers: A 1-year prospective cohort study.

PubMed

Eguchi, Hisashi; Shimazu, Akihito; Kawakami, Norito; Inoue, Akiomi; Tsutsumi, Akizumi

2016-08-01

This study investigated the prospective association between source-specific workplace social support and high-sensitivity C-reactive protein (hs-CRP) levels in workers in Japan. We conducted a 1-year prospective cohort study with 1,487 men and 533 women aged 18-65 years. Participants worked at two manufacturing worksites in Japan and were free of major illness. We used multivariable linear regression analyses to evaluate the prospective association between supervisor and coworker support at baseline, and hs-CRP levels at follow-up. We conducted the analyses separately for men and women. For women, high supervisor support at baseline was significantly associated with lower hs-CRP levels at follow-up (β = -0.109, P < 0.01), whereas coworker support at baseline was not significantly associated with hs-CRP levels at follow-up. Associations between supervisor and coworker support and hs-CRP levels were not significant for men. Supervisor support may have beneficial effects on inflammatory markers in working women. Am. J. Ind. Med. 59:676-684, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Serum uric acid and cancer mortality and incidence: a systematic review and meta-analysis.

PubMed

Dovell, Frances; Boffetta, Paolo

2018-07-01

Elevated serum uric acid (SUA) is a marker of chronic inflammation and has been suggested to be associated with increased risk of cancer, but its antioxidant capacity would justify an anticancer effect. Previous meta-analyses did not include all available results. We conducted a systematic review of prospective studies on SUA level and risk of all cancers and specific cancers, a conducted a meta-analysis based on random-effects models for high versus low SUA level as well as for an increase in 1 mg/dl SUA. The relative risk of all cancers for high versus low SUA level was 1.11 (95% confidence interval: 0.94-1.27; 11 risk estimates); that for a mg/dl increase in SUA level was 1.03 (95% confidence interval: 0.99-1.07). Similar results were obtained for lung cancer (six risk estimates) and colon cancer (four risk estimates). Results for other cancers were sparse. Elevated SUA levels appear to be associated with a modest increase in overall cancer risk, although the combined risk estimate did not reach the formal level of statistical significance. Results for specific cancers were limited and mainly negative.

Bottom-up Design of Three-Dimensional Carbon-Honeycomb with Superb Specific Strength and High Thermal Conductivity.

PubMed

Pang, Zhenqian; Gu, Xiaokun; Wei, Yujie; Yang, Ronggui; Dresselhaus, Mildred S

2017-01-11

Low-dimensional carbon allotropes, from fullerenes, carbon nanotubes, to graphene, have been broadly explored due to their outstanding and special properties. However, there exist significant challenges in retaining such properties of basic building blocks when scaling them up to three-dimensional materials and structures for many technological applications. Here we show theoretically the atomistic structure of a stable three-dimensional carbon honeycomb (C-honeycomb) structure with superb mechanical and thermal properties. A combination of sp 2 bonding in the wall and sp 3 bonding in the triple junction of C-honeycomb is the key to retain the stability of C-honeycomb. The specific strength could be the best in structural carbon materials, and this strength remains at a high level but tunable with different cell sizes. C-honeycomb is also found to have a very high thermal conductivity, for example, >100 W/mK along the axis of the hexagonal cell with a density only ∼0.4 g/cm 3 . Because of the low density and high thermal conductivity, the specific thermal conductivity of C-honeycombs is larger than most engineering materials, including metals and high thermal conductivity semiconductors, as well as lightweight CNT arrays and graphene-based nanocomposites. Such high specific strength, high thermal conductivity, and anomalous Poisson's effect in C-honeycomb render it appealing for the use in various engineering practices.

Unmet Needs of Low Academic Level Adult (0-4th Grade Level) Students: A Follow-Up Study. A Special Demonstration/Teacher Training Project. Final Report.

ERIC Educational Resources Information Center

Portage Township Schools, IN.

An Indiana 310 Project was conducted to determine the needs of very low level adult basic education students (0-4th grade). Specifically, the study sought to answer the following four questions: (1) What brings low academic level students into ABE programs? (2) What aspects of the ABE programs do low academic level students dislike? (3) Why do low…

Improving ELLs' Listening Competence through Written Scaffolds

ERIC Educational Resources Information Center

Abobaker, Reima

2017-01-01

This article reports findings from a quasi-experimental study conducted to provide evidence of the effectiveness of written scaffolds (keyword captions, full captions, and full transcript) for different proficiency levels. The gap that this article fills is the lack of research on the type of written scaffold that a specific proficiency level can…

The Well-Being of the UK Academy, 1998-2004

ERIC Educational Resources Information Center

Kinman, Gail; Jones, Fiona; Kinman, Russell

2006-01-01

This paper compares the findings of two studies, conducted in 1998 and 2004, of academic staff in British universities. It examines the stability over time of working hours, specific work stressors and levels of psychological distress. Comparisons are also made between the levels of psychological distress currently reported by academic staff and…

Differential tissue-specific expression of NtAQP1 in Arabidopsis thaliana reveals a role for this protein in stomatal and mesophyll conductance of CO₂ under standard and salt-stress conditions.

PubMed

Sade, Nir; Gallé, Alexander; Flexas, Jaume; Lerner, Stephen; Peleg, Gadi; Yaaran, Adi; Moshelion, Menachem

2014-02-01

The regulation of plant hydraulic conductance and gas conductance involves a number of different morphological, physiological and molecular mechanisms working in harmony. At the molecular level, aquaporins play a key role in the transport of water, as well as CO₂, through cell membranes. Yet, their tissue-related function, which controls whole-plant gas exchange and water relations, is less understood. In this study, we examined the tissue-specific effects of the stress-induced tobacco Aquaporin1 (NtAQP1), which functions as both a water and CO₂ channel, on whole-plant behavior. In tobacco and tomato plants, constitutive overexpression of NtAQP1 increased net photosynthesis (A(N)), mesophyll CO₂ conductance (g(m)) and stomatal conductance (g(s)) and, under stress, increased root hydraulic conductivity (L(pr)) as well. Our results revealed that NtAQP1 that is specifically expressed in the mesophyll tissue plays an important role in increasing both A(N) and g(m). Moreover, targeting NtAQP1 expression to the cells of the vascular envelope significantly improved the plants' stress response. Surprisingly, NtAQP1 expression in the guard cells did not have a significant effect under any of the tested conditions. The tissue-specific involvement of NtAQP1 in hydraulic and gas conductance via the interaction between the vasculature and the stomata is discussed.

Specific-conductance, water-temperature, and water-level data, San Francisco Bay, California, for water years 2001-2002

USGS Publications Warehouse

Buchanan, P.A.

2003-01-01

This article presents time-series plots of specific-conductance, water-temperature, and water-level data collected in San Francisco Bay during water years 2001 and 2002 (October 1, 2000, through September 30, 2002). Specific-conductance and water-temperature data were recorded at 15-minute intervals at the following US Geological Survey (USGS) locations (Figure 1): • Suisun Bay at Benicia Bridge, near Benicia, California (BEN) (site # 11455780) • Carquinez Strait at Carquinez Bridge, near Crockett, California (CARQ) (site # 11455820) • Napa River at Mare Island Causeway, near Vallejo, California (NAP) (site # 11458370) • San Pablo Strait at Point San Pablo, California (PSP) (site # 11181360) • San Pablo Bay at Petaluma River Channel Marker 9, California (SPB) (site # 380519122262901) • San Francisco Bay at Presidio Military Reservation, California (PRES) (site # 11162690) • San Francisco Bay at Pier 24, at San Francisco, California (P24) (site # 11162700) • San Francisco Bay at San Mateo Bridge, near Foster City, California (SMB) (site # 11162765). Water-level data were recorded only at PSP through January 1, 2001. Suspended-sediment concentration data also were collected at most of these sites and were published by Buchanan and Ganju (2003). The data from PSP, PRES, P24, and SMB were recorded by the California Department of Water Resources (DWR) before 1988, by the USGS National Research Program from 1988 to 1989, and by the USGSDWR cooperative program since 1990. BEN, CARQ, NAP, and SPB were established in 1998 by the USGS.

Familial and temperamental predictors of resilience in children at risk for conduct disorder and depression

PubMed Central

Shannon, Katherine E.; Beauchaine, Theodore P.; Brenner, Sharon L.; Neuhaus, Emily; Gatzke-Kopp, Lisa

2009-01-01

In this study, we evaluated predictors of resilience among 8- to 12-year-old children recruited from primarily low socioeconomic status neighborhoods, 117 of whom suffered from clinical levels of conduct problems and/or depression, and 63 of whom suffered from no significant symptoms. Tests of interactions were conducted between (a) paternal antisocial behavior and maternal depression and (b) several physiological indices of child temperament and emotionality in predicting (c) children’s conduct problems and depression. Both internalizing and externalizing outcomes among children were associated specifically with maternal melancholic depression, and not with nonmelancholic depression. In addition, low levels of respiratory sinus arrhythmia (RSA) among children conferred significant risk for depression, regardless of maternal melancholia, whereas high RSA offered partial protection. Furthermore, high levels of maternal melancholia conferred significant risk for child depression, regardless of paternal antisocial behavior, whereas low levels of maternal melancholia offered partial protection. Finally, low levels of electrodermal responding (EDR) conferred significant risk for conduct problems, regardless of paternal antisocial behavior, whereas high EDR offered partial protection. None of the identified protective factors offered complete immunity from psychopathology. These findings underscore the complexity of resilience and resilience-related processes, and suggest several potential avenues for future longitudinal research. PMID:17705899

Gender differences in the impact of population-level alcohol policy interventions: evidence synthesis of systematic reviews.

PubMed

Fitzgerald, Niamh; Angus, Kathryn; Emslie, Carol; Shipton, Deborah; Bauld, Linda

2016-10-01

Consistent review-level evidence supports the effectiveness of population-level alcohol policies in reducing alcohol-related harms. Such policies interact with well-established social, cultural and biological differences in how men and women perceive, relate to and use alcohol, and with wider inequalities, in ways which may give rise to gender differences in policy effectiveness. This paper aimed to examine the extent to which gender-specific data and analyses were considered in, and are available from, systematic reviews of population-level alcohol policy interventions, and where possible, to conduct a narrative synthesis of relevant data. A prior systematic 'review of reviews' of population level alcohol interventions 2002-2012 was updated to May 2014, all gender-relevant data extracted, and the level and quality of gender reporting assessed. A narrative synthesis of extracted findings was conducted. Sixty-three systematic reviews, covering ten policy areas, were included. Five reviews (8%) consistently provided information on baseline participation by gender for each individual study in the review and twenty-nine (46%) reported some gender-specific information on the impact of the policies under consideration. Specific findings include evidence of possible gender differences in the impact of and exposure to alcohol marketing, and a failure to consider potential unintended consequences and harm to others in most reviews. Gender is poorly reported in systematic reviews of population-level interventions to reduce alcohol-related harm, hindering assessment of the intended and unintended effects of such policies on women and men. © 2016 Society for the Study of Addiction.

Bromide, Chloride, and Sulfate Concentrations, and Specific Conductance, Lake Texoma, Texas and Oklahoma, 2007-08

USGS Publications Warehouse

Baldys, Stanley

2009-01-01

The U.S. Geological Survey, in cooperation with the City of Dallas Water Utilities Division, collected water-quality data from 11 sites on Lake Texoma, a reservoir on the Texas-Oklahoma border, during April 2007-September 2008. At 10 of the sites, physical properties (depth, specific conductance, pH, temperature, dissolved oxygen, and alkalinity) were measured and samples were collected for analysis of selected dissolved constituents (bromide, calcium, magnesium, potassium, sodium, carbonate, bicarbonate, chloride, and sulfate); at one site, only physical properties were measured. The primary constituent of interest was bromide. Bromate can form when ozone is used to disinfect raw water containing bromide, and bromate is a suspected human carcinogen. Chloride and sulfate were of secondary interest. Only the analytical results for bromide, chloride, sulfate, and measured specific conductance are discussed in this report. Median dissolved bromide concentrations ranged from 0.28 to 0.60 milligrams per liter. The largest median dissolved bromide concentration (0.60 milligram per liter at site 11) was from the Red River arm of Lake Texoma. Dissolved bromide concentrations generally were larger in the Red River arm of Lake Texoma than in the Washita arm of the lake. Median dissolved chloride concentrations were largest in the Red River arm of Lake Texoma at site 11 (431 milligrams per liter) and smallest at site 8 (122 milligrams per liter) in the Washita arm. At site 11 in the Red River arm, the mean and median chloride concentrations exceeded the secondary maximum contaminant level of 300 milligrams per liter for chloride established by the 'Texas Surface Water Quality Standards' for surface-water bodies designated for the public water supply use. Median dissolved sulfate concentrations ranged from 182 milligrams per liter at site 4 in the Big Mineral arm to 246 milligrams per liter at site 11 in the Red River arm. None of the mean or median sulfate concentrations exceeded the secondary maximum contaminant level of 300 milligrams per liter. Median specific conductance measurements at sites ranged from 1,120 microsiemens per centimeter at site 8 in the Washita arm to 2,100 microsiemens per centimeter in the Red River arm. The spatial distribution of specific conductance in Lake Texoma was similar to that of bromide and chloride, with larger specific conductance values in the Red River arm compared to those in the Washita arm.

Engineering biosynthetic excitable tissues from unexcitable cells for electrophysiological and cell therapy studies.

PubMed

Kirkton, Robert D; Bursac, Nenad

2011-01-01

Patch-clamp recordings in single-cell expression systems have been traditionally used to study the function of ion channels. However, this experimental setting does not enable assessment of tissue-level function such as action potential (AP) conduction. Here we introduce a biosynthetic system that permits studies of both channel activity in single cells and electrical conduction in multicellular networks. We convert unexcitable somatic cells into an autonomous source of electrically excitable and conducting cells by stably expressing only three membrane channels. The specific roles that these expressed channels have on AP shape and conduction are revealed by different pharmacological and pacing protocols. Furthermore, we demonstrate that biosynthetic excitable cells and tissues can repair large conduction defects within primary 2- and 3-dimensional cardiac cell cultures. This approach enables novel studies of ion channel function in a reproducible tissue-level setting and may stimulate the development of new cell-based therapies for excitable tissue repair.

Effects of Canals and Roads on Hydrologic Conditions and Health of Atlantic White Cedar at Emily and Richardson Preyer Buckridge Coastal Reserve, North Carolina, 2003-2006

USGS Publications Warehouse

Ferrell, Gloria M.; Strickland, A. Gerald; Spruill, Timothy B.

2007-01-01

The effects of canals and roads on hydrologic conditions and on the health of Atlantic white cedar at the Emily and Richardson Preyer Buckridge Coastal Reserve in North Carolina were evaluated by using data collected from the 1980s to 2006. Water levels were monitored along two transects established perpendicular to roads and canals in areas of healthy and unhealthy Atlantic white cedar as part of a study conducted from February 2003 through March 2006. Because of the low hydraulic gradient at the Reserve, the rate and direction of water movement are sensitive to disturbance. Canals increased drainage and contributed to lower water levels in some parts of the Reserve, whereas roads, depending on orientation, impeded drainage. Canals also appeared to facilitate movement of brackish water from the Alligator River into the interior of the Reserve during storms and wind tides. Data indicate that an influx of brackish water occurred in mid-September 2005 several days after the passage of Hurricane Ophelia. Although precipitation amounts and wind speeds associated with Hurricane Ophelia were not large, substantial changes in specific conductance occurred at the canal site on the unhealthy Atlantic white cedar transect. No corresponding increase in specific conductance was observed at the canal site on the healthy Atlantic white cedar transect. The specific conductance of water samples from canals and piezometers was highly correlated with concentrations of chloride and sodium. Ion ratios of some of the water samples, particularly samples with high specific conductance, were similar to those of seawater. Thermal and chemical stratification of water in the canals occurred during summer and winter months, and turnover and mixing occurred in the spring and fall. Upwelling of ground water as a result of excavation for roads did not appear to have a significant effect on the water quality of samples from the canals or piezometers. The specific conductance of water samples from piezometers installed in the root zone of healthy stands of Atlantic white cedar generally was lower than in water samples from unhealthy stands. This pattern also was observed in samples from piezometers installed on the transects and in other areas of the Reserve. Roads appear to have isolated some areas of the Reserve from the high-conductivity water in nearby canals. The paths by which brackish water entered the Reserve cannot be determined from the data obtained during this investigation. It appears that water can enter the Reserve from various directions, depending on wind patterns and water levels in the Alligator River.

Analysis of Mathematics Teachers' Self-Efficacy Levels Concerning the Teaching Process

ERIC Educational Resources Information Center

Ünsal, Serkan; Korkmaz, Fahrettin; Perçin, Safiye

2016-01-01

The purpose of this study is to identify mathematics teachers' opinions on the teaching process self-efficacy levels; and to examine mathematics teachers' teaching process self-efficacy beliefs with regards to specific variables. The study was conducted in Turkey during the second term of the 2015-2016 academic year. The study sample consisted of…

To Be Anxious or Not: Student Teachers in the Practicum

ERIC Educational Resources Information Center

Eksi, Gonca Yangin; Yakisik, Burçak Yilmaz

2016-01-01

High levels of teaching-related anxiety may cause high levels of stress, failure and disappointment in pre-service teachers. The factors that increase anxiety and those that reduce it for student teachers might also be culture-specific. This study was conducted on 52 pre-service language teachers at a state university in Turkey during their…

Utilizing management zones for Rotylenchulus reniformis in Cotton: Effects on nematode levels, crop damage, and Pasteuria sp.

USDA-ARS?s Scientific Manuscript database

The effect of soil texture on nematode levels is the primary basis for site-specific nematode management. Management zones (MZs) are sampled independently and decisions are based on those sample results. MZs based on soil electrical conductivity (EC, a proxy for soil texture) have not been tested ...

An Automated Gasometer for the Teaching Laboratory

ERIC Educational Resources Information Center

Thompson, Frank; Elamari, Matouk

2008-01-01

Measurement of the level of a liquid is needed in many hydrodynamic situations. In the present article, this has been achieved with a conductivity sensor for the specific case of water levels. The use of this system is illustrated by the automation of a gasometer in which the gas is collected in an inverted measuring cylinder resting in a water…

Independent Validation and Verification of automated information systems in the Department of Energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunteman, W.J.; Caldwell, R.

1994-07-01

The Department of Energy (DOE) has established an Independent Validation and Verification (IV&V) program for all classified automated information systems (AIS) operating in compartmented or multi-level modes. The IV&V program was established in DOE Order 5639.6A and described in the manual associated with the Order. This paper describes the DOE IV&V program, the IV&V process and activities, the expected benefits from an IV&V, and the criteria and methodologies used during an IV&V. The first IV&V under this program was conducted on the Integrated Computing Network (ICN) at Los Alamos National Laboratory and several lessons learned are presented. The DOE IV&Vmore » program is based on the following definitions. An IV&V is defined as the use of expertise from outside an AIS organization to conduct validation and verification studies on a classified AIS. Validation is defined as the process of applying the specialized security test and evaluation procedures, tools, and equipment needed to establish acceptance for joint usage of an AIS by one or more departments or agencies and their contractors. Verification is the process of comparing two levels of an AIS specification for proper correspondence (e.g., security policy model with top-level specifications, top-level specifications with source code, or source code with object code).« less

A survey of core and support activities of communicable disease surveillance systems at operating-level CDCs in China.

PubMed

Xiong, Weiyi; Lv, Jun; Li, Liming

2010-11-17

In recent years, problems like insufficient coordination, low efficiency, and heavy working load in national communicable disease surveillance systems in China have been pointed out by many researchers. To strengthen the national communicable disease surveillance systems becomes an immediate concern. Since the World Health Organization has recommended that a structured approach to strengthen national communicable disease surveillance must include an evaluation to existing systems which usually begins with a systematic description, we conducted the first survey for communicable disease surveillance systems in China, in order to understand the situation of core and support surveillance activities at province-level and county-level centers for disease control and prevention (CDCs). A nationwide survey was conducted by mail between May and October 2006 to investigate the implementation of core and support activities of the Notifiable Disease Reporting System (NDRS) and disease-specific surveillance systems in all of the 31 province-level and selected 14 county-level CDCs in Mainland China The comments on the performance of communicable disease surveillance systems were also collected from the directors of CDCs in this survey. The core activities of NDRS such as confirmation, reporting and analysis and some support activities such as supervision and staff training were found sufficient in both province-level and county-level surveyed CDCs, but other support activities including information feedback, equipment and financial support need to be strengthened in most of the investigated CDCs. A total of 47 communicable diseases or syndromes were under surveillance at province level, and 20 diseases or syndromes at county level. The activities among different disease-specific surveillance systems varied widely. Acute flaccid paralysis (AFP), measles and tuberculosis (TB) surveillance systems got relatively high recognition both at province level and county level. China has already established a national communicable disease surveillance framework that combines NDRS and disease-specific surveillance systems. The core and support activities of NDRS were found sufficient, while the implementation of those activities varied among different disease-specific surveillance systems.

Simulation of salinity intrusion along the Georgia and South Carolina coasts using climate-change scenarios

USGS Publications Warehouse

Conrads, Paul; Roehl, Edwin A.; Daamen, Ruby C.; Cook, John B.

2013-01-01

Potential changes in climate could alter interactions between environmental and societal systems and adversely affect the availability of water resources in many coastal communities. Changes in streamflow patterns in conjunction with sea-level rise may change the salinity-intrusion dynamics of coastal rivers. Several municipal water-supply intakes are located along the Georgia and South Carolina coast that are proximal to the present day saltwater-freshwater interface of tidal rivers. Increases in the extent of salinity intrusion resulting from climate change could threaten the availability of freshwater supplies in the vicinity of these intakes. To effectively manage these supplies, water-resource managers need estimates of potential changes in the frequency, duration, and magnitude of salinity intrusion near their water-supply intakes that may occur as a result of climate change. This study examines potential effects of climate change, including altered streamflow and sea-level rise, on the dynamics of saltwater intrusion near municipal water-supply intakes in two coastal areas. One area consists of the Atlantic Intracoastal Waterway (AIW) and the Waccamaw River near Myrtle Beach along the Grand Strand of the South Carolina Coast, and the second area is on or near the lower Savannah River near Savannah, Georgia. The study evaluated how future sea-level rise and a reduction in streamflows can potentially affect salinity intrusion and threaten municipal water supplies and the biodiversity of freshwater tidal marshes in these two areas. Salinity intrusion occurs as a result of the interaction between three principal forces—streamflow, mean coastal water levels, and tidal range. To analyze and simulate salinity dynamics at critical coastal gaging stations near four municipal water-supply intakes, various data-mining techniques, including artificial neural network (ANN) models, were used to evaluate hourly streamflow, salinity, and coastal water-level data collected over a period exceeding 10 years. The ANN models were trained (calibrated) to learn the specific interactions that cause salinity intrusions, and resulting models were able to accurately simulate historical salinity dynamics in both study areas. Changes in sea level and streamflow quantity and timing can be simulated by the salinity intrusion models to evaluate various climate-change scenarios. The salinity intrusion models for the study areas are deployed in a decision support system to facilitate the use of the models for management decisions by coastal water-resource managers. The report describes the use of the salinity-intrusion models decision support system to evaluate salinity-intrusion dynamics for various climate-change scenarios, including incremental increases in sea level in combination with incremental decreases in streamflow. Operation of municipal water-treatment plants is problematic when the specific-conductance values for source water are greater than 1,000 to 2,000 microsiemens per centimeter (µS/cm). High specific-conductance values contribute to taste problems that require treatment. Data from a gage downstream from a municipal water intake indicate specific conductance exceeded 1,000 µS/cm about 5.4 percent of the time over the 14-year period from August 1995 to August 2008. Simulations of specific conductance at this gaging station that incorporates sea-level rises resulted in a doubling of the exceedances to 11.0 percent for a 1-foot increase and 17.6 percent for a 2-foot increase. The frequency of intrusion of water with specific conductance values of 1,000 µS/cm was less sensitive to incremental reductions in streamflow than to incremental increases in sea level. Simulations of conditions associated with a 10-percent reduction in streamflow, in combination with a 1-foot rise in sea level, increased the percentage of time specific conductance exceeded 1,000 µS/cm at this site from 11.0 to 13.3 percent, and a 20-percent reduction in streamflow increased the percentage of time to 16.6 percent. Precipitation and temperature data from a global circulation model were used, after scale adjustments, as input to a watershed model of the Yadkin-Pee Dee River basin, which flows into the Waccamaw River and Atlantic Intracoastal Waterway study area in South Carolina. The simulated streamflow for historical conditions and projected climate change in the future was used as input for the ANN model in decision support system. Results of simulations incorporating climate-change projections for alterations in streamflow indicate an increase in the frequency of salinity-intrusion events and a shift in the seasonal occurrence of the intrusion events from the summer to the fall.

Sustainability knowledge using “AKASA” model among architecture students from Klang Valley private universities, Malaysia.

NASA Astrophysics Data System (ADS)

Kuppusamy, Sivaraman; Faris Khamidi, Mohd; Sheng, Lee Xia; Salvi Mari, Tamil

2017-12-01

The study intend to investigate sustainability knowledge using “AKASA” model. This model comprises all the literacy level which is the awareness, knowledge, attitude, skills and action. 234 students from 5 selected private universities were surveyed using questionnaires. Students were specifically selected from year 2 and year 3 from private universities in Klang valley, Malaysia. The study intends to investigate the environmental literacy level specifically the knowledge variable. The parametric study was conducted with descriptive analysis and the results shows that the environmental knowledge is at high level compared to other environmental literacy variables among year 2, year 3 and combine year 2 and year 3.

Effects of streamflow diversion on a fish population: combining empirical data and individual-based models in a site-specific evaluation

Treesearch

Bret C. Harvey; Jason L. White; Rodney J. Nakamoto; Steven F. Railsback

2014-01-01

Resource managers commonly face the need to evaluate the ecological consequences of specific water diversions of small streams. We addressed this need by conducting 4 years of biophysical monitoring of stream reaches above and below a diversion and applying two individual-based models of salmonid fish that simulated different levels of behavioral complexity. The...

Spatial and temporal distribution of specific conductance, boron, and phosphorus in a sewage-contaminated aquifer near Ashumet Pond, Cape Cod, Massachusetts

USGS Publications Warehouse

Bussey, K.W.; Walter, D.A.

1996-01-01

Spatial and temporal distributions of specific conductance, boron, and phosphorus were determined in a sewage-contaminated sand and gravel aquifer near Ashumet Pond, Cape Cod, Massachusetts. The source of contamination is secondarily treated sewage that has been discharged onto rapid- infiltration sand beds at the Massachusetts Military Reservation since 1936. Contaminated ground water containing as much as 2 milligrams per liter of dissolved phosphorus is discharging into Ashumet Pond, and there is concern that the continued discharge of phosphorus into the pond will accelerate eutrophication of the pond. Water-quality data collected from observation wells and multilevel samplers from June through July 1995 were used to delineate the spatial distributions of specific conductance, boron, and phosphorus. Temporal distributions were determined using sample-interval-weighted average concen- trations calculated from data collected in 1993, 1994, and 1995. Specific conductances were greater than 400 microsiemens per centimeter at 25C as far as 1,200 feet downgradient from the infiltration beds. Boron concentrations were greater than 400 micrograms per liter as far as 1,800 feet down- gradient from the beds and phosphorus concen- trations were greater than 3.0 milligrams per liter as far as 1,200 feet from the beds. Variability in distributions of specific conductance and boron concentrations is attributed to the history and distribution of sewage disposal onto the infiltration beds. The distribution of phosphorus concentrations also is related to the history and distribution of sewage disposal onto the beds but additional variability is caused by chemical interactions with the aquifer materials. Temporal changes in specific conductance and boron from 1993 to 1995 were negligible, except in the lower part of the plume (below an altitude of about 5 feet above sea level), where changes in weighted-average specific conductance were greater than 100 microsiemens per centimeter at 25C. Temporal changes in phosphorus generally were small except in the lower part of the plume, where weighted-average phosphorus concentrations decreased more than 1.3 milligrams per liter from 1993 to 1994. This decrease was accompanied by an increase in specific conductance. High concen- trations of phosphorus associated with low and moderate specific conductances possibly are the result of rapid phosphorus desorption in response to an influx of uncontaminated ground water. As a result of the cessation of sewage disposal in December 1995, clean, oxygenated water moving into contaminated parts of the aquifer may cause rapid desorption of sorbed phosphorus and temporarily result in high dissolved phosphorus concentrations in the aquifer.

Daily and seasonal variability of pH, dissolved oxygen, temperature, and specific conductance in the Colorado River between the forebay of Glen Canyon, Dam and Lees Ferry, northeastern Arizona, 1998-99

USGS Publications Warehouse

Flynn, Marilyn E.; Hart, Robert J.; Marzolf, G. Richard; Bowser, Carl J.

2001-01-01

The productivity of the trout fishery in the tailwater reach of the Colorado River downstream from Glen Canyon Dam depends on the productivity of lower trophic levels. Photosynthesis and respiration are basic biological processes that control productivity and alter pH and oxygen concentration. During 1998?99, data were collected to aid in the documentation of short- and long-term trends in these basic ecosystem processes in the Glen Canyon reach. Dissolved-oxygen, temperature, and specific-conductance profile data were collected monthly in the forebay of Glen Canyon Dam to document the status of water chemistry in the reservoir. In addition, pH, dissolved-oxygen, temperature, and specific-conductance data were collected at five sites in the Colorado River tailwater of Glen Canyon Dam to document the daily, seasonal, and longitudinal range of variation in water chemistry that could occur annually within the Glen Canyon reach.

Water levels and water quality in the Mississippi River Valley alluvial aquifer in eastern Arkansas, 2012

USGS Publications Warehouse

Schrader, Tony P.

2015-01-01

Water samples were collected in the summer of 2012 from142 wells completed in the alluvial aquifer and measured onsite for specific conductance, temperature, and pH. Samples were collected from 94 wells for dissolved chloride analysis. Specific conductance ranged from 91 microsiemens per centimeter at 25 degrees Celsius (μS/cm at 25 °C) in Drew County to 984 μS/cm at 25 °C in Monroe County. The mean specific conductance was 547 μS/cm at 25 °C. Temperature ranged from 18.1 degrees Celsius (°C) in Crittenden County to 22.4 °C in Prairie County. The mean temperature was 22.1 °C. The pH ranged from 8.3 in Randolph County to 6.2 in Drew County and had a median of 7.3. Dissolved chloride concentrations ranged from 3.34 milligrams per liter (mg/L) in Randolph County to 182 mg/L in Lincoln County. The mean chloride concentration was 27.6 mg/L.

Addressing uncertainty in vulnerability assessments [Chapter 5

Treesearch

Linda Joyce; Molly Cross; Evan Girvatz

2011-01-01

This chapter addresses issues and approaches for dealing with uncertainty specifically within the context of conducting climate change vulnerability assessments (i.e., uncertainties related to identifying and modeling the sensitivities, levels of exposure, and adaptive capacity of the assessment targets).

Salivary oxytocin in adolescents with conduct problems and callous-unemotional traits.

PubMed

Levy, Tomer; Bloch, Yuval; Bar-Maisels, Meytal; Gat-Yablonski, Galia; Djalovski, Amir; Borodkin, Katy; Apter, Alan

2015-12-01

Callous-unemotional (CU) traits correlate with the severity and prognosis of conduct disorder in youth. The neuropeptide oxytocin (OT) has been linked to prosocial behaviors, including empathy and collaboration with others. This study discusses a possible role for OT in the biology of delinquent behavior. We hypothesized that in delinquent youth OT secretion will correlate with the severity of conduct problems and specifically with the level of CU traits. The study group included 67 male adolescents (mean age 16.2 years) undergoing residential treatment, previously assessed by an open clinical interview and history for the psychiatric diagnosis. Staff based Inventory of Callous-Unemotional traits for psychopathy and Strength and Difficulties Questionnaire were administered, and patients' medical and social personal files were systematically coded for previous history of antisocial acts using the Brown-Goodwin Questionnaire. Salivary OT was assayed by ELISA. Salivary OT levels were inversely correlated with conduct problems severity on Strength and Difficulties Questionnaire (r = -0.27; p ≤ 0.01). Recorded history of antisocial acts did not correlate with current OT levels. Odds ratio (OR) for significant CU traits among subjects with conduct problems was increased in low-OT (OR = 14, p ≤ 0.05) but not in high-OT subjects (OR = 6, p ≥ 0.05). Children with conduct problems and low levels of salivary OT are at risk for significant CU traits. These results suggest a possible role for salivary OT as a biomarker for CU traits and conduct problems severity.

Summary of the U.S. Geological Survey National Field Quality Assurance Program from 1979 through 1997

USGS Publications Warehouse

Stanley, D.L.; Boozer, T.M.; Schroder, L.J.

1998-01-01

Since the inception of the U.S. Geological Survey National Field Quality Assurance Program, over 85,000 proficiency samples have been analyzed by water-quality analysts. This includes more than 10,000 alkalinity samples, more than 15,000 pH samples, and more than 16,000 specific conductance samples, which were analyzed from 1990 through 1997, and a total of more than 43,000 proficiency samples analyzed from 1979 through 1989. The analyte values were evaluated to determine the fourth-spread, a measure of the width of the middle half of the data, and the F-pseudosigma, a robust replacement for the standard deviation, for each of the different measurement ranges. The result of the statistical evaluation showed that the vast majority of reference sample measurements made by water-quality analysts were within acceptable ranges. From 1990 to 1997, the measurement of pH had the highest level of acceptable results, 98.4 percent, followed by specific conductance with 95.2 percent acceptable results, and alkalinity with 88.6 percent acceptable results. The statistical summary of pH indicates the calculated fourth-spread values for the entire tested range is +0.06 pH units. For specific conductance, the magnitude of the fourth-spread increases as the magnitude of the specific conductance ranges increases. The average relative fourth-spread percent for all reported specific conductance values is +1.8 percent. From 1990 through 1997, the evaluation of the results for alkalinity measurement for the average fourth-spread was determined to be + 3.3 milligrams per liter as calcium carbonate.

Nanotube antibody biosensor arrays for the detection of circulating breast cancer cells

NASA Astrophysics Data System (ADS)

Shao, Ning; Wickstrom, Eric; Panchapakesan, Balaji

2008-11-01

Recent reports have shown that nanoscale electronic devices can be used to detect a change in electrical properties when receptor proteins bind to their corresponding antibodies functionalized on the surface of the device, in extracts from as few as ten lysed tumor cells. We hypothesized that nanotube-antibody devices could sensitively and specifically detect entire live cancer cells. We report for the first time a single nanotube field effect transistor array, functionalized with IGF1R-specific and Her2-specific antibodies, which exhibits highly sensitive and selective sensing of live, intact MCF7 and BT474 human breast cancer cells in human blood. Those two cell lines both overexpress IGF1R and Her2, at different levels. Single or small bundle of nanotube devices that were functionalized with IGF1R-specific or Her2-specific antibodies showed 60% decreases in conductivity upon interaction with BT474 or MCF7 breast cancer cells in two µl drops of blood. Control experiments with non-specific antibodies or with MCF10A control breast cells produced a less than 5% decrease in electrical conductivity, illustrating the high sensitivity for whole cell binding by these single nanotube-antibody devices. We postulate that the free energy change due to multiple simultaneous cell-antibody binding events exerted stress along the nanotube surface, decreasing its electrical conductivity due to an increase in band gap. Because the free energy change upon cell-antibody binding, the stress exerted on the nanotube, and the change in conductivity are specific to a specific antigen-antibody interaction; these properties might be used as a fingerprint for the molecular sensing of circulating cancer cells. From optical microscopy observations during sensing, it appears that the binding of a single cell to a single nanotube field effect transistor produced the change in electrical conductivity. Thus we report a nanoscale oncometer with single cell sensitivity with a diameter 1000 times smaller than a cancer cell that functions in a drop of fresh blood.

Engineering biosynthetic excitable tissues from unexcitable cells for electrophysiological and cell therapy studies

PubMed Central

Kirkton, Robert D.; Bursac, Nenad

2012-01-01

Patch-clamp recordings in single-cell expression systems have been traditionally used to study the function of ion channels. However, this experimental setting does not enable assessment of tissue-level function such as action potential (AP) conduction. Here we introduce a biosynthetic system that permits studies of both channel activity in single cells and electrical conduction in multicellular networks. We convert unexcitable somatic cells into an autonomous source of electrically excitable and conducting cells by stably expressing only three membrane channels. The specific roles that these expressed channels have on AP shape and conduction are revealed by different pharmacological and pacing protocols. Furthermore, we demonstrate that biosynthetic excitable cells and tissues can repair large conduction defects within primary 2- and 3-dimensional cardiac cell cultures. This approach enables novel studies of ion channel function in a reproducible tissue-level setting and may stimulate the development of new cell-based therapies for excitable tissue repair. PMID:21556054

Regulation of Kv2.1 K+ conductance by cell surface channel density

PubMed Central

Fox, Philip D.; Loftus, Rob J.; Tamkun, Michael M.

2013-01-01

The Kv2.1 voltage-gated K+ channel is found both freely diffusing over the plasma membrane and concentrated in micron-sized clusters localized to the soma, proximal dendrites and axon initial segment of hippocampal neurons. In transfected HEK cells, Kv2.1 channels within cluster microdomains are non-conducting. Using TIRF microscopy the number of GFP-tagged Kv2.1 channels on the HEK cell surface was compared to K+ channel conductance measured by whole-cell voltage-clamp of the same cell. This approach indicated that as channel density increases non-clustered channels cease conducting. At the highest density observed, only 4% of all channels were conducting. Mutant Kv2.1 channels that fail to cluster also possessed the non-conducting state with 17% conducting K+ at higher surface densities. The non-conducting state was specific to Kv2.1 as Kv1.4 was always conducting regardless of the cell-surface expression level. Anti-Kv2.1 immuno-fluorescence intensity, standardized to Kv2.1 surface density in transfected HEK cells, was used to determine the expression levels of endogenous Kv2.1 in cultured rat hippocampal neurons. Endogenous Kv2.1 levels were compared to the number of conducting channels determined by whole-cell voltage clamp. Only 13 and 27% of the endogenous Kv2.1 was conducting in neurons cultured for 14 and 20 days, respectively. Together these data indicate that the non-conducting state depends primarily on surface density as opposed to cluster location and that this non-conducting state also exists for native Kv2.1 found in cultured hippocampal neurons. This excess of Kv2.1 protein relative to K+ conductance further supports a non-conducting role for Kv2.1 in excitable tissues. PMID:23325261

Site-Specific Analyses for Demonstrating Compliance with 10 CFR 61 Performance Objectives - 12179

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grossman, C.J.; Esh, D.W.; Yadav, P.

2012-07-01

The U.S. Nuclear Regulatory Commission (NRC) is proposing to amend its regulations at 10 CFR Part 61 to require low-level radioactive waste disposal facilities to conduct site-specific analyses to demonstrate compliance with the performance objectives in Subpart C. The amendments would require licensees to conduct site-specific analyses for protection of the public and inadvertent intruders as well as analyses for long-lived waste. The amendments would ensure protection of public health and safety, while providing flexibility to demonstrate compliance with the performance objectives, for current and potential future waste streams. NRC staff intends to submit proposed rule language and associated regulatorymore » basis to the Commission for its approval in early 2012. The NRC staff also intends to develop associated guidance to accompany any proposed amendments. The guidance is intended to supplement existing low-level radioactive waste guidance on issues pertinent to conducting site-specific analyses to demonstrate compliance with the performance objectives. The guidance will facilitate implementation of the proposed amendments by licensees and assist competent regulatory authorities in reviewing the site-specific analyses. Specifically, the guidance provides staff recommendations on general considerations for the site-specific analyses, modeling issues for assessments to demonstrate compliance with the performance objectives including the performance assessment, intruder assessment, stability assessment, and analyses for long-lived waste. This paper describes the technical basis for changes to the rule language and the proposed guidance associated with implementation of the rule language. The NRC staff, per Commission direction, intends to propose amendments to 10 CFR Part 61 to require licensees to conduct site-specific analyses to demonstrate compliance with performance objectives for the protection of public health and the environment. The amendments would require a performance assessment to demonstrate protection of the general population from releases of radioactivity, an assessment to demonstrate protection of a potential inadvertent intruder, and a long-term analysis to assess how the design of the facility considers the potential radiological impacts associated with disposal of long-lived waste streams. Concurrently, the NRC staff intends to propose associated guidance to facilitate the implementation of the requirements to conduct site-specific analyses. In proposing these amendments to the regulation and associated guidance, the NRC staff has conducted extensive public outreach since 2009 including three public meetings and four briefings of the NRC's Advisory Committee on Reactor Safeguards. The NRC staff plans to submit the proposed amendments to the regulations to the Commission in early 2012. Subsequently, the proposed amendments and associated guidance would be published in the Federal Register for public comment pending approval of the proposed amendments to the regulations by the Commission. Following the public comment period, NRC staff plans to address public comments and revise, as necessary, the regulations and associated guidance before publishing a final rule, which is anticipated in 2013. (authors)« less

Estimate of aquifer properties by numerically simulating ground-water/surface-water interactions, Fort Wainwright, Alaska

USGS Publications Warehouse

Nakanishi, Allen S.; Lilly, Michael R.

1998-01-01

MODFLOW, a finite-difference model of ground-water flow, was used to simulate the flow of water between the aquifer and the Chena River at Fort Wainwright, Alaska. The model was calibrated by comparing simulated ground-water hydrographs to those recorded in wells during periods of fluctuating river levels. The best fit between simulated and observed hydrographs occurred for the following: 20 feet per day for vertical hydraulic conductivity, 400 feet per day for horizontal hydraulic conductivity, 1:20 for anisotropy (vertical to horizontal hydraulic conductivity), and 350 per feet for riverbed conductance. These values include a 30 percent adjustment for geometry effects. The estimated values for hydraulic conductivities of the alluvium are based on assumed values of 0.25 for specific yield and 0.000001 per foot for specific storage of the alluvium; the values assumed for bedrock are 0.1 foot per day horizontal hydraulic conductivity, 0.005 foot per day vertical hydraulic conductivity, and 0.0000001 per foot for specific storage. The resulting diffusivity for the alluvial aquifer is 1,600 feet per day. The estimated values of these hydraulic properties are nearly proportional to the assumed value of specific yield. These values were not found to be sensitive to the assumed values for bedrock. The hydrologic parameters estimated using the cross-sectional model are only valid when taken in context with the other values (both estimated and assumed) used in this study. The model simulates horizontal and vertical flow directions near the river during periods of varying river stage. This information is useful for interpreting bank-storage effects, including the flow of contaminants in the aquifer near the river.

Determining the Computer Literacy Levels of Vocational Teachers in Southern Nevada and Developing a Computer In-Service Program for Vocational Teachers.

ERIC Educational Resources Information Center

Pomeroy, James L.

A study was conducted to achieve the following objectives: (1) to determine the computer skills level of the vocational teachers in Southern Nevada; (2) to design a computer literacy inservice program targeting the specific instructional needs of vocational teachers with deficient skills; (3) to develop a plan for evaluating the inservice training…

Interrelating Selected Aspects of Home Economics and Physical Education for a Health Program in the Middle School at the Sixth Grade Level.

ERIC Educational Resources Information Center

Lamb, Virginia Malzahn

This study was conducted to develop, implement, and evaluate a 9-week unit interrelating the health aspects of home economics and physical education at the sixth grade level. The curriculum, which emphasizes physical, social, and mental health, was designed by: (1) diagnosing needs of the students, (2) formulating specific objectives, (3)…

Highly conductive and porous activated reduced graphene oxide films for high-power supercapacitors.

PubMed

Zhang, Li Li; Zhao, Xin; Stoller, Meryl D; Zhu, Yanwu; Ji, Hengxing; Murali, Shanthi; Wu, Yaping; Perales, Stephen; Clevenger, Brandon; Ruoff, Rodney S

2012-04-11

We present a novel method to prepare highly conductive, free-standing, and flexible porous carbon thin films by chemical activation of reduced graphene oxide paper. These flexible carbon thin films possess a very high specific surface area of 2400 m(2) g(-1) with a high in-plane electrical conductivity of 5880 S m(-1). This is the highest specific surface area for a free-standing carbon film reported to date. A two-electrode supercapacitor using these carbon films as electrodes demonstrated an excellent high-frequency response, an extremely low equivalent series resistance on the order of 0.1 ohm, and a high-power delivery of about 500 kW kg(-1). While higher frequency and power values for graphene materials have been reported, these are the highest values achieved while simultaneously maintaining excellent specific capacitances and energy densities of 120 F g(-1) and 26 W h kg(-1), respectively. In addition, these free-standing thin films provide a route to simplify the electrode-manufacturing process by eliminating conducting additives and binders. The synthetic process is also compatible with existing industrial level KOH activation processes and roll-to-roll thin-film fabrication technologies. © 2012 American Chemical Society

Tolerance of a high-protein baked-egg product in egg-allergic children.

PubMed

Saifi, Maryam; Swamy, Nithya; Crain, Maria; Brown, L Steven; Bird, John Andrew

2016-05-01

Egg allergy is one of the most common immunoglobulin E (IgE)-mediated food allergies. Extensively heating egg has been found to decrease its allergenicity and 64% to 84% of children allergic to egg have been found to tolerate baked-egg products. Because there is no reliable method for predicting baked-egg tolerance, oral food challenges remain the gold standard. Prior studies have reported on baked-egg challenges using up to 2.2 g of egg white (EW) protein. To establish whether children with egg allergy would pass a baked-egg challenge to a larger amount of egg protein and the potential criteria for predicting the likelihood of baked-egg tolerance. A chart review was conducted of all patients 6 months to 18 years of age with egg allergy who underwent oral baked-egg challenges at Children's Medical Center Dallas over a 2-year period. Challenges were conducted in the clinic with a 3.8-g baked-egg product. Fifty-nine of 94 patients (63%) tolerated the 3.8-g baked-egg product. The presence of asthma (P < .01), EW skin prick test (SPT; P < .01) reactive wheal, and EW-specific IgE level (P = .02) correlated with baked-egg reactivity, whereas ovomucoid-specific IgE level did not. The positive predictive value approached 66% at an EW SPT reactive wheal of 10 mm and 60% for an EW-specific IgE level of 8 kUA/L. Most subjects with egg allergy tolerated baked egg. This study is the first to use 3.8 g of EW protein for the challenges. The EW SPT wheal diameter and EW-specific IgE levels were the best predictors of baked-egg tolerance. Copyright © 2016 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

The Association Between the Levels of Thyroid Hormones and Peripheral Nerve Conduction in Patients with Type 2 Diabetes Mellitus.

PubMed

Zhu, Fan-Fan; Yang, Li-Zhen

2018-06-26

Type 2 diabetes has an underlying pathology with thyroid dysfunction. However, few studies have investigated the association between thyroid hormones and diabetic peripheral neuropathy. Our aim was to evaluate the relationship between thyroid hormones and electrophysiological properties of peripheral nerves in type 2 diabetes. The medical records of 308 patients with type 2 diabetes were enrolled in this study. Subjects stratified by sex were divided into subgroups based on the diagnosis of nerve conduction study. The nerve conduction parameters were separately described with the spectrum of thyroid hormones. Multivariate regression models to analyze the potential links between thyroid hormones and nerve conduction parameters. The serum free triiodine thyronine levels between normal and abnormal nerve conduction groups were statistically different in total (4.55±0.65 vs 4.37±0.63, P<0.05) and female diabetic patients (4.46±0.50 vs 4.14±0.57, P<0.01). Moreover, the summed amplitude and velocity Z score of female and male increased with free triiodine thyronine levels (P<0.05). Sex-specific binary logistic regression models showed that free triiodine thyronine levels were associated with decreased odds of abnormal nerve conduction diagnosis (odds ratio [95%CI]=0.151[0.047-0.186]) and low tertile of summed amplitude Z score (odds ratio [95%CI]=0.283[0.099-0.809]) in female. In total patients, free triiodine thyronine level was negatively associated with odds of abnormal nerve conduction (odds ratio [95%CI]=0.436 [0.226-0.842]), low tertile of summed velocity (odds ratio [95%CI]=0.44[0.226-0.858]) and amplitude (odds ratio [95%CI]=0.436[0.227-0.838) Z score. Serum free triiodine thyronine level is associated with nerve conduction in diabetes. Low free triiodine thyronine may be a potential risk for diabetic peripheral neuropathy. © Georg Thieme Verlag KG Stuttgart · New York.

An Evaluation of Public Preferences for Superfund Site Cleanup, Volume II: Pilot Study (1995)

EPA Pesticide Factsheets

In volume II, the authors present the detailed technical results of a pilot market research study that was conducted to determine preferences for the specific type and level of cleanup desired by the public at Superfund sites.

45 CFR 164.308 - Administrative safeguards.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., contain, and correct security violations. (ii) Implementation specifications: (A) Risk analysis (Required). Conduct an accurate and thorough assessment of the potential risks and vulnerabilities to the... vulnerabilities to a reasonable and appropriate level to comply with § 164.306(a). (C) Sanction policy (Required...

Electronic transport in armchair graphene nanoribbon under double magnetic barrier modulation

NASA Astrophysics Data System (ADS)

Wang, Haiyan; Wu, Chao; Xie, Fang; Zhang, Xiaojiao; Zhou, Guanghui

2018-03-01

We present a theoretical investigation of the transport properties and the magnetoresistance effect in armchair graphene nanoribbons (AGNRs) under modulation by two magnetic barriers. The energy levels are found to be degenerate for a metallic AGNR but are not degenerate for a semiconducting AGNR. However, the conductance characteristics show quantized plateaus in both the metallic and semiconducting cases. When the magnetization directions of the barriers change from parallel to antiparallel, the conductance plateau in the metallic AGNR shows a degenerate feature due to matching between the transport modes in different regions. As the barrier height increases, the conductance shows more oscillatory behavior with sharp peaks and troughs. Specifically, the initial position of nonzero conductance for the metallic AGNR system moves towards a higher energy regime, which indicates that an energy gap has been opened. In addition, the magnetoresistance ratio also shows plateau structures in certain specific energy regions. These results may be useful in the design of electron devices based on AGNR nanostructures.

The Importance of Context in Screening in Occupational Health Interventions in Organizations: A Mixed Methods Study.

PubMed

Vignoli, Michela; Nielsen, Karina; Guglielmi, Dina; Tabanelli, Maria C; Violante, Francesco S

2017-01-01

In occupational health interventions, there is a debate as to whether standardized or tailored measures should be used to identify which aspects of the psychosocial work environment should be targeted in order to improve employees' well-being. Using the Job Demands-Resources model, the main aim of the present study is to demonstrate how a mixed methods approach to conducting screening enables the identification of potential context-dependent demands and resources in the workplace, which should to be targeted by the intervention. Specifically, we used a mixed methods exploratory sequential research design. First, we conducted four focus groups ( N = 37) in a sample of employees working in grocery stores in Italy. The qualitative results allowed to identify one possible context-specific job demand: the use of a work scheduling IT software, whose implementation resulted in a high rotation between different market's departments. From the qualitative results, this context-specific demand seemed to be related to workers' well-being. Thus, in a subsequent questionnaire survey ( N = 288), we included this demand together with generic measures of social support and psychological well-being. Results confirmed that this context-specific job demand was related to emotional exhaustion. Furthermore, it was found that social support moderated the relationship between this specific job demand and emotional exhaustion showing among employees whose activities depended on the IT software, employees that perceived higher levels of social support from colleagues experienced lower levels of emotional exhaustion with respect to their colleagues who perceived lower levels of social support. The present study confirms that mixed methods approach is useful in occupational health intervention research and offers a way forward on helping organizations prioritize their intervention activities.

The Importance of Context in Screening in Occupational Health Interventions in Organizations: A Mixed Methods Study

PubMed Central

Vignoli, Michela; Nielsen, Karina; Guglielmi, Dina; Tabanelli, Maria C.; Violante, Francesco S.

2017-01-01

In occupational health interventions, there is a debate as to whether standardized or tailored measures should be used to identify which aspects of the psychosocial work environment should be targeted in order to improve employees’ well-being. Using the Job Demands-Resources model, the main aim of the present study is to demonstrate how a mixed methods approach to conducting screening enables the identification of potential context-dependent demands and resources in the workplace, which should to be targeted by the intervention. Specifically, we used a mixed methods exploratory sequential research design. First, we conducted four focus groups (N = 37) in a sample of employees working in grocery stores in Italy. The qualitative results allowed to identify one possible context-specific job demand: the use of a work scheduling IT software, whose implementation resulted in a high rotation between different market’s departments. From the qualitative results, this context-specific demand seemed to be related to workers’ well-being. Thus, in a subsequent questionnaire survey (N = 288), we included this demand together with generic measures of social support and psychological well-being. Results confirmed that this context-specific job demand was related to emotional exhaustion. Furthermore, it was found that social support moderated the relationship between this specific job demand and emotional exhaustion showing among employees whose activities depended on the IT software, employees that perceived higher levels of social support from colleagues experienced lower levels of emotional exhaustion with respect to their colleagues who perceived lower levels of social support. The present study confirms that mixed methods approach is useful in occupational health intervention research and offers a way forward on helping organizations prioritize their intervention activities. PMID:28848468

Comparison of Ramadan-specific education level in patients with diabetes seen at a Primary and a Tertiary care center of Karachi-Pakistan.

PubMed

Masood, Shabeen Naz; Alvi, Syed Faraz Danish; Ahmedani, Muhammad Yakoob; Kiran, Shazia; Zeeshan, Nimra Fatima; Basit, Abdul; Shera, A Samad

2014-01-01

To compare Ramadan-specific education level in fasting patients with diabetes at a Primary and a Tertiary care center. An observational study was conducted in the Outpatient departments of a Primary care center and a Tertiary care center in Karachi-Pakistan. Recruitment of patients started at the end of Ramadan 2011 and continued till three months after Ramadan 2011. All patients with diabetes who observed fast during the month of Ramadan 2011 were included in the study. In Primary care center, patients were attended by physicians only, while at Tertiary care center patients were seen by physicians, diabetes educator and dietician. For data collection, standardized questionnaire based interview was conducted on one to one basis by trained healthcare professionals. Same questionnaire was used at both the centers. A total of 392 and 199 patients with diabetes recruited at Primary and Tertiary care centers, respectively. Ramadan-specific diabetes education received by 213 (55%) and 123 (61.80%) patients with diabetes at Primary and Tertiary care centers, respectively. Compared to Primary care center, patients at Tertiary care centers were more aware about components of Ramadan-specific diabetes education such as signs and symptoms of hypoglycemia and hyperglycemia, dose of medicines/insulin during Ramadan fasting, dose of medicines/insulin when not fasting, self-monitoring of blood glucose, dietary modifications, physical activity, adequate nutrition and adequate hydration during Ramadan (p<0.05). It was observed that Ramadan-specific education level of patients at Tertiary care center was significantly better compared to patients at Primary care center. Copyright © 2014 Diabetes India. Published by Elsevier Ltd. All rights reserved.

Effectiveness of household reverse-osmosis systems in a Western U.S. region with high arsenic in groundwater

USGS Publications Warehouse

Walker, M.; Seiler, R.L.; Meinert, M.

2008-01-01

It is well known to the public in Lahontan Valley in rural Nevada, USA, that local aquifers produce water with varied, but sometimes very high concentrations of arsenic (> 4??ppm). As a result, many residents of the area have installed household reverse-osmosis (RO) systems to produce drinking water. We examined performance of RO systems and factors associated with arsenic removal efficiency in 59 households in Lahontan Valley. The sampling results indicated that RO systems removed an average of 80.2% of arsenic from well water. In 18 of the 59 households, arsenic concentrations exceeded 10??ppb in treated water, with a maximum in treated water of 180??ppb. In 3 of the 59 households, RO treatment had little effect on specific conductance, indicating that the RO system was not working properly. Two main factors lead to arsenic levels in treated water exceeding drinking-water standards in the study area. First, arsenic concentrations were high enough in some Lahontan Valley wells that arsenic levels exceeded 10??ppb even though RO treatment removed more than 95% of the arsenic. Second, trivalent As+ 3 was the dominant arsenic species in approximately 15% of the wells, which significantly reduced treatment efficiency. Measurements of specific conductance indicated that efficiency in reducing arsenic levels did not always correlate with reductions in total dissolved solids. As a consequence, improvements in taste of the water or simple measurements of specific conductance made by technicians to test RO systems can mislead the public into assuming the water meets safety standards. Actual measurements of treated water are necessary to assure that household RO systems are reducing arsenic concentrations to safe levels, particularly in areas where groundwater has high arsenic concentrations or where As+ 3 is the dominant species. ?? 2007 Elsevier B.V. All rights reserved.

High specific heat superconducting composite

DOEpatents

Steyert, Jr., William A.

1979-01-01

A composite superconductor formed from a high specific heat ceramic such as gadolinium oxide or gadolinium-aluminum oxide and a conventional metal conductor such as copper or aluminum which are insolubly mixed together to provide adiabatic stability in a superconducting mode of operation. The addition of a few percent of insoluble gadolinium-aluminum oxide powder or gadolinium oxide powder to copper, increases the measured specific heat of the composite by one to two orders of magnitude below the 5.degree. K. level while maintaining the high thermal and electrical conductivity of the conventional metal conductor.

Cross-well slug testing in unconfined aquifers: A case study from the Sleepers River Watershed, Vermont

USGS Publications Warehouse

Belitz, K.; Dripps, W.

1999-01-01

Normally, slug test measurements are limited to the well in which the water level is perturbed. Consequently, it is often difficult to obtain reliable estimates of hydraulic properties, particularly if the aquifer is anisotropic or if there is a wellbore skin. In this investigation, we use partially penetrating stress and observation wells to evaluate specific storage, radial hydraulic conductivity and anisotropy of the aquifer, and the hydraulic conductivity of the borehole skin. The study site is located in the W9 subbasin of the Sleepers River Research Watershed, Vermont. At the site, ~3 m of saturated till are partially penetrated by a stress well located in the center of the unconfined aquifer and six observation wells located above, below, and at the depth of the stress well at radial distances of 1.2 and 2.4 m. The observation wells were shut in with inflatable packers. The semianalytical solution of Butler (1995) was used to conduct a sensitivity analysis and to interpret slug test results. The sensitivity analysis indicates that the response of the stress well is primarily sensitive to radial hydraulic conductivity, less sensitive to anisotropy and the conductivity of the borehole skin, and nearly insensitive to specific storage. In contrast, the responses of the observation wells are sensitive to all four parameters. Interpretation of the field data was facilitated by generating type curves in a manner analogous to the method of Cooper et al. (1967). Because the value of radial hydraulic conductivity is obtained from a match point, the number of unknowns is reduced to three. The estimated values of radial hydraulic conductivity and specific storage are comparable to those derived from the methods of Bouwer and Rice (1976) and Cooper et al. (1967). The values and skin conductivity, however, could not have been obtained without the use of observation wells.Normally, slug test measurements are limited to the well in which the water level is perturbed. Consequently, it is often difficult to obtain reliable estimates of hydraulic properties, particularly if the aquifer is anisotropic or if there is a wellbore skin. In this investigation, we use partially penetrating stress and observation wells to evaluate specific storage, radial hydraulic conductivity and anisotropy of the aquifer, and the hydraulic conductivity of the borehole skin. The study site is located in the W9 subbasin of the Sleepers River Research Watershed, Vermont. At the site, approximately 3 m of saturated till are partially penetrated by a stress well located in the center of the unconfined aquifer and six observation wells located above, below, and at the depth of the stress well at radial distances of 1.2 and 2.4 m. The observation wells were shut in with inflatable packers. The semianalytical solution of Buffer (1995) was used to conduct a sensitivity analysis and to interpret slug test results. The sensitivity analysis indicates that the response of the stress well is primarily sensitive to radial hydraulic conductivity, less sensitive to anisotropy and the conductivity of the borehole skin, and nearly insensitive to specific storage. In contrast, the responses of the observation wells are sensitive to all four parameters. Interpretation of the field data was facilitated by generating type curves in a manner analogous to the method of Cooper et al. (1967). Because the value of radial hydraulic conductivity is obtained from a match point, the number of unknowns is reduced to three. The estimated values of radial hydraulic conductivity and specific storage are comparable to those derived from the methods of Bouwer and Rice (1976) and Cooper et al. (1967). The values and skin conductivity, however, could not have been obtained without the use of observation wells.

Water resources data, Kentucky. Water year 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

McClain, D.L.; Byrd, F.D.; Brown, A.C.

1991-12-31

Water resources data for the 1991 water year for Kentucky consist of records of stage, discharge, and water quality of streams and lakes; and water-levels of wells. This report includes daily discharge records for 115 stream-gaging stations. It also includes water-quality data for 38 stations sampled at regular intervals. Also published are 13 daily temperature and 8 specific conductance records, and 85 miscellaneous temperature and specific conductance determinations for the gaging stations. Suspended-sediment data for 12 stations (of which 5 are daily) are also published. Ground-water levels are published for 23 recording and 117 partial sites. Precipitation data at amore » regular interval is published for 1 site. Additional water data were collected at various sites not involved in the systematic data-collection program and are published as miscellaneous measurement and analyses. These data represent that part of the National Water Data System operated by the US Geological Survey and cooperation State and Federal agencies in Kentucky.« less

Emotional communication in families of conduct problem children with high versus low callous-unemotional traits.

PubMed

Pasalich, Dave S; Dadds, Mark R; Vincent, Lucy C; Cooper, Francesca A; Hawes, David J; Brennan, John

2012-01-01

This study examined relationships between parent-child emotional communication and callous-unemotional (CU) traits and conduct problems. References to negative and positive emotions made by clinic-referred boys (3-9 years) and their parents were coded from direct observations of family interactions involving the discussion of shared emotional experiences. Although frequencies of parents' emotion expression did not generally relate to levels of CU traits, boys higher on CU traits were observed to be more expressive of negative emotions in conversation with their caregivers-specifically for sadness and fear. Independent coders did not judge these children to be less genuine in their emotion expression compared to their low-CU counterparts. We also examined whether CU traits moderated the relationship between parents' focus on emotions and conduct problem severity. Higher levels of maternal focus on negative emotions were found to be associated with lower conduct problems in high-CU boys but related to higher conduct problems in low-CU boys. Frequencies of fathers' emotional communication were unrelated to either child CU traits or conduct problems. We discuss the implications of these findings for the conceptualization of CU traits in preadolescent children, and interventions for conduct problems in children elevated on these traits.

A systematic review of validated methods for identifying anaphylaxis, including anaphylactic shock and angioneurotic edema, using administrative and claims data.

PubMed

Schneider, Gary; Kachroo, Sumesh; Jones, Natalie; Crean, Sheila; Rotella, Philip; Avetisyan, Ruzan; Reynolds, Matthew W

2012-01-01

The Food and Drug Administration's Mini-Sentinel pilot program initially aims to conduct active surveillance to refine safety signals that emerge for marketed medical products. A key facet of this surveillance is to develop and understand the validity of algorithms for identifying health outcomes of interest from administrative and claims data. This article summarizes the process and findings of the algorithm review of anaphylaxis. PubMed and Iowa Drug Information Service searches were conducted to identify citations applicable to the anaphylaxis health outcome of interest. Level 1 abstract reviews and Level 2 full-text reviews were conducted to find articles using administrative and claims data to identify anaphylaxis and including validation estimates of the coding algorithms. Our search revealed limited literature focusing on anaphylaxis that provided administrative and claims data-based algorithms and validation estimates. Only four studies identified via literature searches provided validated algorithms; however, two additional studies were identified by Mini-Sentinel collaborators and were incorporated. The International Classification of Diseases, Ninth Revision, codes varied, as did the positive predictive value, depending on the cohort characteristics and the specific codes used to identify anaphylaxis. Research needs to be conducted on designing validation studies to test anaphylaxis algorithms and estimating their predictive power, sensitivity, and specificity. Copyright © 2012 John Wiley & Sons, Ltd.

Limitations in conduct and reporting of cochrane reviews rarely inhibit the determination of the validity of evidence for clinical decision-making.

PubMed

Alper, Brian S; Fedorowicz, Zbys; van Zuuren, Esther J

2015-08-01

To determine how often clinical conclusions derived from Cochrane Reviews have uncertain validity due to review conduct and reporting deficiencies. We evaluated 5142 clinical conclusions in DynaMed (an evidence-based point-of-care clinical reference) based on 4743 Cochrane Reviews. Clinical conclusions with level 2 evidence due to shortcomings in the review's conduct or reporting (rather than deficiencies in the underlying evidence) were confirmed by a DynaMed editor and two Cochrane Review authors. Thirty-one Cochrane Reviews (0.65%) had confirmed deficiencies in conduct and reporting as the reason for classifying 37 assessed clinical conclusions (0.72%) as level 2 evidence. In all cases, it was not feasible for the assessors to specify a clear criticism of the studies included in the reviews. The deficiencies were specific to not accounting for dropouts (2) or inadequate assessment and reporting of allocation concealment (11), other specific trial quality criteria (14), or all trial quality criteria (4). Cochrane Reviews provide high-quality assessment and synthesis of evidence, with fewer than 1% of Cochrane Reviews having limitations which hinder the summary of best current evidence for clinical decision-making. We expect this will further decrease following recent Cochrane quality initiatives. © 2015 Chinese Cochrane Center, West China Hospital of Sichuan University and Wiley Publishing Asia Pty Ltd.

Drinking-water quality and variations in water levels in the fractured crystalline-rock aquifer, west-central Jefferson County, Colorado

USGS Publications Warehouse

Hall, Dennis C.; Johnson, Carl J.

1979-01-01

In parts of Jefferson County, CO, water for domestic use from the fractured crystalline-rock aquifer contained excessive concentrations of major ions, coliform bacteria, trace elements, or radiochemicals. Based on results of analyses from 26 wells, water from 21 of the wells contained excessive concentrations of one or more constituents. Drinking water standards were exceeded for fluoride in water from 2 wells, nitrate plus nitrite in 2 wells, dissolved solids in 1 well, iron in 6 wells, manganese in 8 wells, zinc in 2 wells, coliform bacteria in 4 wells, gross alpha radiation in 11 wells and possibly 4 more, and gross beta radiation possibly in 1 well. Local variations in concentrations of 15 chemical constituents, specific conductance, and water temperature were statistically significant. Specific conductance increased significantly during 1973-75 only in the vicinity of Indian Hills. Annual range in depths to water in 11 observation wells varied from 1 to 15 feet. The shallowest water levels were recorded in late winter, usually in February. The deepest water levels occurred during summer or fall, depending on the well and the year. Three-year trends in water level changes in 6 of the 11 wells indicated decreasing water storage in the aquifer. (USGS).

The Impact of Intraclass Correlation on the Effectiveness of Level-Specific Fit Indices in Multilevel Structural Equation Modeling

PubMed Central

Hsu, Hsien-Yuan; Lin, Jr-Hung; Kwok, Oi-Man; Acosta, Sandra; Willson, Victor

2016-01-01

Several researchers have recommended that level-specific fit indices should be applied to detect the lack of model fit at any level in multilevel structural equation models. Although we concur with their view, we note that these studies did not sufficiently consider the impact of intraclass correlation (ICC) on the performance of level-specific fit indices. Our study proposed to fill this gap in the methodological literature. A Monte Carlo study was conducted to investigate the performance of (a) level-specific fit indices derived by a partially saturated model method (e.g., CFIPS_B and CFIPS_W) and (b) SRMRW and SRMRB in terms of their performance in multilevel structural equation models across varying ICCs. The design factors included intraclass correlation (ICC: ICC1 = 0.091 to ICC6 = 0.500), numbers of groups in between-level models (NG: 50, 100, 200, and 1,000), group size (GS: 30, 50, and 100), and type of misspecification (no misspecification, between-level misspecification, and within-level misspecification). Our simulation findings raise a concern regarding the performance of between-level-specific partial saturated fit indices in low ICC conditions: the performances of both TLIPS_B and RMSEAPS_B were more influenced by ICC compared with CFIPS_B and SRMRB. However, when traditional cutoff values (RMSEA≤ 0.06; CFI, TLI≥ 0.95; SRMR≤ 0.08) were applied, CFIPS_B and TLIPS_B were still able to detect misspecified between-level models even when ICC was as low as 0.091 (ICC1). On the other hand, both RMSEAPS_B and SRMRB were not recommended under low ICC conditions. PMID:29795901

Is post-event processing a social anxiety specific or transdiagnostic cognitive process in the anxiety spectrum?

PubMed

Laposa, Judith M; Collimore, Kelsey C; Rector, Neil A

2014-11-01

Research on post-event processing (PEP), where individuals conduct a post-mortem evaluation of a social situation, has focused primarily on its relationship with social anxiety. The current study examined: 1) levels of PEP for a standardized event in different anxiety disorders; 2) the relationship between peak anxiety levels during this event and subsequent PEP; and 3) the relationship between PEP and disorder-specific symptom severity. Participants with primary DSM-IV diagnoses of social anxiety disorder (SAD), obsessive compulsive disorder (OCD), panic disorder with/without agoraphobia (PD/A), or generalized anxiety disorder (GAD) completed diagnosis specific symptom measures before attending group cognitive behavioural therapy (CBT) specific to their diagnosis. Participants rated their peak anxiety level during the first group therapy session, and one week later rated PEP in the context of CBT. The results indicated that all anxiety disorder groups showed heightened and equivalent PEP ratings. Peak state anxiety during the first CBT session predicted subsequent level of PEP, irrespective of diagnostic group. PEP ratings were found to be associated with disorder-specific symptom severity in SAD, GAD, and PD/A, but not in OCD. PEP may be a transdiagnostic process with relevance to a broad range of anxiety disorders, not just SAD.

[Recording and data processing of electrical signals of the specific atrioventricular conduction pathways in man].

PubMed

Héron, F; Mialet, G; Schuller, C; Breton, D; Perrin, J; Degeorges, M

1979-01-01

Signals of the electrical activity of the specific atrioventricular conduction pathways were recorded with an unipolar lead to obtain an exact time reference. The amplifier used had special characteristics: high gain settings (up to 300,000), very low noise levels, and wide filter range (2 Hz - 1,600 Hz). The low amplitude of the signals under study, of the order of a microvolt, and the wide filter range of the amplifier necessitated placing the patient in a Faraday cage. The signals recorded on magnetic tape were treated by a system of analysis for signal treatment. The method of averaging was used to extract the signal from background noise especially that arising from somatic muscle. The amplitude of the Hisian signal was much larger than that usually obtained with other methods. The intervals were determined with precision of the order of 1 millisecond. Frequential analysis of the signals gave another representation of the information contained in the time signals. This new representation seems to give better discrimination of the different zones of activation of the specific atrioventricular conduction pathways.

Toward competency-based curriculum: Application of workplace-based assessment tools in the National Saudi Arabian Anesthesia Training Program.

PubMed

Boker, Ama

2016-01-01

The anesthesia training program of the Saudi Commission for health specialties has introduced a developed competency-based anesthesia residency program starting from 2015 with the utilization of the workplace-based assessment (WBA) tools, namely mini-clinical exercises (mini-CEX), direct observation of procedural skills (DOPS), and case-based discussion (CBD). This work aimed to describe the process of development of anesthesia-specific list of mini-CEX, DOPS, and CBD tools within the Saudi Arabian Anesthesia Training Programs. To introduce the main concepts of formative WBA tools and to develop anesthesia-specific applications for each of the selected WBA tools, four 1-day workshops were held at the level of major training committees at eastern (Dammam), western (Jeddah), and central (Riyadh) regions in the Kingdom were conducted. Sixty-seven faculties participated in these workshops. After conduction of the four workshops, the anesthesia-specific applications setting of mini-CEX, DOPS, and CBD tools among the 5-year levels were fully described. The level of the appropriate consultation skills was divided according to the case complexity adopted from the American Society of Anesthesiologists physical classification for adult and obstetric and pediatric patient as well as the type of the targeted anesthetic procedure. WBA anesthesia-specific lists of mini-CEX, DOPS, and CBD forms were easily incorporated first into guidelines to help the first stage of implementation of formative assessment in the Saudi Arabian Anesthesia Residency Program, and this can be helpful to replicate such program within other various training programs in Saudi Arabia and abroad.

Water levels and water quality in the Sparta-Memphis aquifer (middle Claiborne aquifer) in Arkansas, spring-summer 2009

USGS Publications Warehouse

Schrader, T.P.

2013-01-01

The U.S. Geological Survey in cooperation with the Arkansas Natural Resources Commission and the Arkansas Geological Survey has monitored water levels in the Sparta Sand of Claiborne Group and Memphis Sand of Claiborne Group (herein referred to as the Sparta Sand and the Memphis Sand, respectively) since the 1920s. Groundwater withdrawals have increased while water levels have declined since monitoring was initiated. Herein, aquifers in the Sparta Sand and Memphis Sand will be referred to as the Sparta-Memphis aquifer throughout Arkansas. During the spring of 2009, 324 water levels were measured in wells completed in the Sparta-Memphis aquifer and used to produce a regional potentiometric-surface map. During the summer of 2009, 64 water-quality samples were collected and measured for specific conductance, temperature, and pH from wells completed in the Sparta-Memphis aquifer. The regional direction of groundwater flow in the Sparta-Memphis aquifer is generally to the south-southeast in the northern half of Arkansas and to the east and south in the southern half of Arkansas, away from the outcrop area except where affected by large groundwater withdrawals. The highest and lowest water-level altitudes measured in the Sparta-Memphis aquifer were 325 feet above and 157 feet below National Geodetic Vertical Datum of 1929, respectively. Eight depressions (generally represented by closed contours) are located in the following counties: Bradley; Ashley; Calhoun; Cleveland; Columbia; Arkansas, Jefferson, Lincoln, and Prairie; Cross and Poinsett; and Union. Two large depressions shown on the 2009 potentiometric-surface map, centered in Jefferson and Union Counties, are the result of large withdrawals for industrial, irrigation, or public supply. The depression centered in Jefferson County deepened and expanded in recent years into Arkansas and Prairie Counties. The area enclosed within the 40-foot contour on the 2009 potentiometric-surface map has expanded south to the Drew County line and moved west from the intersection of Arkansas, Jefferson, and Lincoln Counties when compared with the 2007 potentiometric-surface map. To the north, east, and west, the 40-foot contour is comparable to the 2007 potentiometric-surface map. The lowest water-level altitude measurement during 2009 in the center of the depression in Union County represents a rise of 42 feet since 2003. The area enclosed by the lowest altitude contour, 140 feet below National Geodetic Vertical Datum of 1929, on the 2009 potentiometric-surface map is about half the area on the 2007 potentiometric-surface map. In the depression in western Poinsett and Cross Counties, the 140-foot contour extended north to the Poinsett-Craighead County line and south across Cross County about two-thirds of the distance to the St. Francis County line. A water-level difference map was constructed using water-level measurements made during 2005 and 2009 from 309 wells. The difference in water level between 2005 and 2009 ranged from -74.6 to 60.2 feet. Areas with a general rise in water levels occur in central Columbia County, southern Jefferson County, and most of Union County. In the area around west-central Union County, water levels rose as much as 60.2 feet with water levels in 18 wells rising 20 feet or more, representing an average annual rise of 5 feet or more. Water levels generally declined throughout most of the rest of Arkansas. Hydrographs were constructed using a minimum of 25 years of water-level measurements at each of 206 wells. During the period 1985–2009, mean annual water levels rose in Calhoun, Columbia, Lafayette, and Union Counties, about 1.3 feet per year (ft/yr), 0.2 ft/yr, 0.1 ft/yr, and 0.6 ft/yr, respectively. Mean annual water-level declines between 0.0 and 2.3 ft/yr occurred in all other counties. In western Arkansas County, water-level altitudes in a continuously monitored well declined 60 feet during the irrigation season (April to September). Specific conductance ranged from 43 microsiemens per centimeter at 25 degrees Celsius (μS/cm) in Ouachita County to 1,230 μS/cm in Phillips County. The mean specific conductance was 392 μS/cm. Although there is a regional increase in specific conductance to the east and south, specific conductance values greater than 700 μS/cm occurred in samples from wells in Arkansas, Ashley, Monroe, Phillips, and Union Counties.

Results of borehole geophysical logging and hydraulic tests conducted in Area D supply wells, former U.S. Naval Air Warfare Center, Warminster, Pennsylvania

USGS Publications Warehouse

Sloto, Ronald A.; Grazul, Kevin E.

1998-01-01

Borehole geophysical logging, aquifer tests, and aquifer-isolation (packer) tests were conducted in four supply wells at the former U.S. Naval Air Warfare Center (NAWC) in Warminster, PA, to identify the depth and yield of water-bearing zones, occurrence of borehole flow, and effect of pumping on nearby wells. The study was conducted as part of an ongoing evaluation of ground-water contamination at the NAWC. Caliper, natural-gamma, single-point resistance, fluid resistivity, and fluid temperature logs and borehole television surveys were run in the supply wells, which range in depth from 242 to 560 ft (feet). Acoustic borehole televiewer and borehole deviation logs were run in two of the wells. The direction and rate of borehole-fluid movement under non-pumping conditions were measured with a high-resolution heatpulse flowmeter. The logs were used to locate water-bearing fractures, determine probable zones of vertical borehole-fluid movement, and determine the depth to set packers. An aquifer test was conducted in each well to determine open-hole specific capacity and the effect of pumping the open borehole on water levels in nearby wells. Specific capacities ranged from 0.21 to 1.7 (gal/min)/ft (gallons per minute per foot) of drawdown. Aquifer-isolation tests were conducted in each well to determine depth-discrete specific capacities and to determine the effect of pumping an individual fracture or fracture zone on water levels in nearby wells. Specific capacities of individual fractures and fracture zones ranged from 0 to 2.3 (gal/min)/ft. Most fractures identified as water-producing or water-receiving zones by borehole geophysical methods produced water when isolated and pumped. All hydrologically active fractures below 250 ft below land surface were identified as water-receiving zones and produced little water when isolated and pumped. In the two wells greater then 540 ft deep, downward borehole flow to the deep water-receiving fractures is caused by a large difference in head (as much as greater then 49 ft) between water-bearing fractured in the upper and lower part of the borehole. Vertical distribution of specific capacity between land surface and 250 ft below land surface is not related to depth.

Prediction of the Thermal Conductivity of Refrigerants by Computational Methods and Artificial Neural Network.

PubMed

Ghaderi, Forouzan; Ghaderi, Amir H; Ghaderi, Noushin; Najafi, Bijan

2017-01-01

Background: The thermal conductivity of fluids can be calculated by several computational methods. However, these methods are reliable only at the confined levels of density, and there is no specific computational method for calculating thermal conductivity in the wide ranges of density. Methods: In this paper, two methods, an Artificial Neural Network (ANN) approach and a computational method established upon the Rainwater-Friend theory, were used to predict the value of thermal conductivity in all ranges of density. The thermal conductivity of six refrigerants, R12, R14, R32, R115, R143, and R152 was predicted by these methods and the effectiveness of models was specified and compared. Results: The results show that the computational method is a usable method for predicting thermal conductivity at low levels of density. However, the efficiency of this model is considerably reduced in the mid-range of density. It means that this model cannot be used at density levels which are higher than 6. On the other hand, the ANN approach is a reliable method for thermal conductivity prediction in all ranges of density. The best accuracy of ANN is achieved when the number of units is increased in the hidden layer. Conclusion: The results of the computational method indicate that the regular dependence between thermal conductivity and density at higher densities is eliminated. It can develop a nonlinear problem. Therefore, analytical approaches are not able to predict thermal conductivity in wide ranges of density. Instead, a nonlinear approach such as, ANN is a valuable method for this purpose.

Prediction of the Thermal Conductivity of Refrigerants by Computational Methods and Artificial Neural Network

PubMed Central

Ghaderi, Forouzan; Ghaderi, Amir H.; Ghaderi, Noushin; Najafi, Bijan

2017-01-01

Background: The thermal conductivity of fluids can be calculated by several computational methods. However, these methods are reliable only at the confined levels of density, and there is no specific computational method for calculating thermal conductivity in the wide ranges of density. Methods: In this paper, two methods, an Artificial Neural Network (ANN) approach and a computational method established upon the Rainwater-Friend theory, were used to predict the value of thermal conductivity in all ranges of density. The thermal conductivity of six refrigerants, R12, R14, R32, R115, R143, and R152 was predicted by these methods and the effectiveness of models was specified and compared. Results: The results show that the computational method is a usable method for predicting thermal conductivity at low levels of density. However, the efficiency of this model is considerably reduced in the mid-range of density. It means that this model cannot be used at density levels which are higher than 6. On the other hand, the ANN approach is a reliable method for thermal conductivity prediction in all ranges of density. The best accuracy of ANN is achieved when the number of units is increased in the hidden layer. Conclusion: The results of the computational method indicate that the regular dependence between thermal conductivity and density at higher densities is eliminated. It can develop a nonlinear problem. Therefore, analytical approaches are not able to predict thermal conductivity in wide ranges of density. Instead, a nonlinear approach such as, ANN is a valuable method for this purpose. PMID:29188217

Cultural Pluralism Climate Survey Study.

ERIC Educational Resources Information Center

Langan, A. Bud; Keeler, Laura

A campus climate study was conducted at Olympic College (OC), in Washington, to measure student, staff, and faculty perceptions of acceptance, support, and understanding of diverse groups on campus. Specifically, the student and staff survey instruments requested participants' level of agreement or disagreement with respect to 22 statements about…

Production and validation of recombinant adeno-associated virus for channelrhodopsin expression in neurons.

PubMed

Lin, John Y

2013-01-01

Recent discovery of the light-activated ion channel, channelrhodopsin (ChR), has provided researchers a powerful and convenient tool to manipulate the membrane potential of specific cells with light. With genetic targeting of these channels and illumination of light to a specific location, the experimenter can selectively activate the voltage-gated ion channels (VGICs) of ChR-expressing cells, initiating electrical signaling in temporally and spatially precise manners. In neuroscience research, this can be used to study electrical signal processing within one neuron at the cellular level, or the synaptic connectivity between neurons at the circuitry level. To conduct experiments with ChRs, these exogenous channels need to be introduced into the cells of interest, commonly through a viral approach. This chapter provides an overview of the design, production, and validation of recombinant adeno-associated virus (rAAV) for ChR expression that can be used in vitro or in vivo to infect neurons. The virus produced can be used to conduct "optogenetic" experiments in behaving animals, in vitro preparations and cultured cells, and can be used to study signal transduction and processing at a cellular or circuitry level.

Polymer-Single Wall Carbon Nanotube Composites for Potential Spacecraft Applications

NASA Technical Reports Server (NTRS)

Park, C.; Ounaies, Z.; Watson, K. A.; Pawlowski, K.; Lowther, S. E.; Connell, J. W.; Siochi, E. J.; Harrison, J. S.; St.Clair, T. L.; Bushnell, Dennis M. (Technical Monitor)

2002-01-01

Polymer-single wall carbon nanotube (SWNT) composite films were prepared and characterized as part of an effort to develop polymeric materials with improved combinations of properties for potential use on future spacecraft. Next generation spacecraft will require ultra-lightweight materials that possess specific and unique combinations of properties such as radiation and atomic oxygen resistance, low solar absorptivity, high thermal emissitivity, electrical conductivity, tear resistance, ability to be folded and seamed, and good mechanical properties. The objective of this work is to incorporate sufficient electrical conductivity into space durable polyimides to mitigate static charge build-up. The challenge is to obtain this level of conductivity (10(exp -8) S/cm) without degrading other properties of importance, particularly optical transparency. Several different approaches were attempted to fully disperse the SWNTs into the polymer matrix. These included high shear mixing, sonication, and synthesizing the polymers in the presence of pre-dispersed SWNTs. Acceptable levels of conductivity were obtained at loading levels less than one tenth weight percent SWNT without significantly sacrificing optical properties. Characterization of the nanocomposite films and the effect of SWNT concentration and dispersion on the conductivity, solar absorptivity, thermal emissivity, mechanical and thermal properties were discussed. Fibers and non-woven porous mats of SWNT reinforced polymer nanocomposite were produced using electrospinning.

Criticality Safety Evaluation of Standard Criticality Safety Requirements #1-520 g Operations in PF-4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yamanaka, Alan Joseph Jr.

Guidance has been requested from the Nuclear Criticality Safety Division (NCSD) regarding processes that involve 520 grams of fissionable material or less. This Level-3 evaluation was conducted and documented in accordance with NCS-AP-004 (Ref. 1), formerly NCS-GUIDE-01. This evaluation is being written as a generic evaluation for all operations that will be able to operate using a 520-gram mass limit. Implementation for specific operations will be performed using a Level 1 CSED, which will confirm and document that this CSED can be used for the specific operation as discussed in NCS-MEMO-17-007 (Ref. 2). This Level 3 CSED updates and supersedesmore » the analysis performed in NCS-TECH-14-014 (Ref. 3).« less

Observation of giant conductance fluctuations in a protein

NASA Astrophysics Data System (ADS)

Zhang, Bintian; Song, Weisi; Pang, Pei; Zhao, Yanan; Zhang, Peiming; Csabai, István; Vattay, Gábor; Lindsay, Stuart

2017-12-01

Proteins are insulating molecular solids, yet even those containing easily reduced or oxidized centers can have single-molecule electronic conductances that are too large to account for with conventional transport theories. Here, we report the observation of remarkably high electronic conductance states in an electrochemically inactive protein, the ∼200 kD α V β 3 extracellular domain of human integrin. Large current pulses (up to nA) were observed for long durations (many ms, corresponding to many pC of charge transfer) at large gap (>5 nm) distances in an STM when the protein was bound specifically by a small peptide ligand attached to the electrodes. The effect is greatly reduced when a homologous, weakly binding protein (α 4 β 1) is used as a control. In order to overcome the limitations of the STM, the time- and voltage-dependence of the conductance were further explored using a fixed-gap (5 nm) tunneling junction device that was small enough to trap a single protein molecule at any one time. Transitions to a high conductance (∼nS) state were observed, the protein being ‘on’ for times from ms to tenths of a second. The high-conductance states only occur above ∼100 mV applied bias, and thus are not an equilibrium property of the protein. Nanoamp two-level signals indicate the specific capture of a single molecule in an electrode gap functionalized with the ligand. This offers a new approach to label-free electronic detection of single protein molecules. Electronic structure calculations yield a distribution of energy level spacings that is consistent with a recently proposed quantum-critical state for proteins, in which small fluctuations can drive transitions between localized and band-like electronic states.

Observation of Giant Conductance Fluctuations in a Protein

PubMed Central

Zhang, Bintian; Song, Weisi; Pang, Pei; Zhao, Yanan; Zhang, Peiming; Csabai, István; Vattay, Gábor; Lindsay, Stuart

2017-01-01

Proteins are insulating molecular solids, yet even those containing easily reduced or oxidized centers can have single-molecule electronic conductances that are too large to account for with conventional transport theories. Here, we report the observation of remarkably high electronic conductance states in an electrochemically-inactive protein, the ~200 kD αVβ3 extracelluar domain of human integrin. Large current pulses (up to nA) were observed for long durations (many ms, corresponding to many pC of charge transfer) at large gap (>5nm) distances in an STM when the protein was bound specifically by a small peptide ligand attached to the electrodes. The effect is greatly reduced when a homologous, weakly-binding protein (α4β1) is used as a control. In order to overcome the limitations of the STM, the time- and voltage-dependence of the conductance were further explored using a fixed-gap (5 nm) tunneling junction device that was small enough to trap a single protein molecule at any one time. Transitions to a high conductance (~ nS) state were observed, the protein being “on” for times from ms to tenths of a second. The high-conductance states only occur above ~ 100mV applied bias, and thus are not an equilibrium property of the protein. Nanoamp two-level signals indicate the specific capture of a single molecule in an electrode gap functionalized with the ligand. This offers a new approach to label-free electronic detection of single protein molecules. Electronic structure calculations yield a distribution of energy level spacings that is consistent with a recently proposed quantum-critical state for proteins, in which small fluctuations can drive transitions between localized and band-like electronic states. PMID:29552645

Columbia River Component Data Gap Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

L. C. Hulstrom

2007-10-23

This Data Gap Analysis report documents the results of a study conducted by Washington Closure Hanford (WCH) to compile and reivew the currently available surface water and sediment data for the Columbia River near and downstream of the Hanford Site. This Data Gap Analysis study was conducted to review the adequacy of the existing surface water and sediment data set from the Columbia River, with specific reference to the use of the data in future site characterization and screening level risk assessments.

Detection of PCT and urinary β2 -MG enhances the accuracy for localization diagnosing pediatric urinary tract infection.

PubMed

Fang, Jian; Luan, Jiangwei; Zhu, Gaohong; Qi, Chang; Wang, Dandan

2017-09-01

The purpose of this article was to investigate whether the combination of urinary beta 2 microglobulin (urinary β 2 -MG) and procalcitonin (PCT) diagnosis could enhance the localization diagnostic precision of pediatric urinary tract infection comparing with single diagnosis. A study was conducted in the Nephrology Department of Wuhan women and children's health care centre. This study incorporated 85 participants, including 35 children who were diagnosed as upper urinary tract infection (UUTI) with the symptom of fever and 50 children who conducted lower urinary tract infection (LUTI). Levels of PCT and urinary β 2 -MG in both UUTI and LUTI patients were measured and compared. The level of PCT and β 2 -MG were both significantly higher in UUTI group compared with in LUTI group. AUC of urinary β 2 -MG ROC (sensitivity of 71.4%, specificity of 90.0%) was significantly smaller than that of PCT ROC (sensitivity of 77.1%, specificity of 96.0%) in the single diagnosis. Although in the combined diagnosis, the sensitivity and specificity increased to 88.6% and 98%, respectively. Both PCT and β 2 -MG could be used to localize the UTI. Introducing urinary β 2 -MG into PCT diagnosis could increase the sensitivity and specificity of UTI lesion diagnosis in clinical practice. © 2016 The Authors Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc.

Transcriptional profiling of resistant and susceptible buffalograsses in response to Blissus occiduus (Hemiptera: Blissidae) feeding

USDA-ARS?s Scientific Manuscript database

Understanding plant resistance mechanisms at a molecular level would provide valuable insights into the biological pathways impacted by insect feeding, and help explain specific plant tolerance mechanisms. As a first step in this process, we conducted next generation sequencing using RNA extracted f...

Effects of suspended sulfates on human health.

PubMed Central

French, J G

1975-01-01

Recent evidence from epidemiologic studies conducted in several areas of the United States shows an association of excess risk of asthmatic attacks with elevated levels of suspended sulfates within specific temperature ranges. These findings are disscussed in the context of experimental animal studies which tend to support these observations. PMID:1157797

Improved population exposure factors in the meta-analysis of air pollution health effects

EPA Science Inventory

Numerous time-series studies have reported significant associations between ambient PM2.5 levels and increased mortality and morbidity. A recent mortality study conducted by Franklin et al. 2007 in 27 U.S. cities has reported significant heterogeneity among city-specific effect e...

Chapter 6. Dwarf mistletoe surveys

Treesearch

J.A. Muir; B. Moody

2002-01-01

Dwarf mistletoe surveys are conducted for a variety of vegetation management objectives. Various survey and sampling techniques are used either at a broad, landscape scale in forest planning or program review, or at an individual, stand, site level for specific project implementation. Standard and special surveys provide data to map mistletoe distributions and quantify...

Variable rate application of nematicides on cotton fields: A promising site-specific management strategy.

USDA-ARS?s Scientific Manuscript database

Field tests were conducted to determine if differences in response to nematicide application (i.e., root-knot nematode (RKN) population levels, cotton yield, and profitability) occurred among RKN management zones (MZ). The MZ were delineated using variables related to soil texture, including appare...

Interaction of Trichoderma asperellum with Phytophthora ramorum inoculum soil populations and enzyme secretion

Treesearch

Supriya Sharma; Wolfgang Schweigkofler; Karen Suslow; Timothy L. Widmer

2017-01-01

There is a continuing desire to investigate the potential of biological control to manage the spread of Phytophthora ramorum. A specific isolate of Trichoderma asperellum has been demonstrated to be effective in reducing P. ramorum soil populations to non-detectable levels. This study was conducted...

Life Satisfaction Among Korean Children and Youth: A Developmental Perspective

ERIC Educational Resources Information Center

Park, Nansook

2005-01-01

A cross-sectional study of developmental differences and similarities in the levels and correlates of life satisfaction was conducted with 716 South Korean students in elementary, middle and high school. With age, global and domain-specific life satisfaction (with family, school, living environment and self) decreased; satisfaction with friends…

Changes in biodiversity and ecosystem function downstream from mountaintop removal and valley fill coal mining

EPA Science Inventory

Mountaintop removal and valley fill coal mining has altered the physicochemical landscape of the Central Appalachian region in the U.S. Increased specific conductance and levels of component ions downstream from valley fill sites are toxic to aquatic life and can negatively impa...

Sounds Like a Winner.

ERIC Educational Resources Information Center

Rittner-Heir, Robbin M.

2001-01-01

Explains how the Ocoee Middle School (Orlando, Florida) improved the ability of students to hear in their classrooms and gained improvements in their attention levels and their conduct. Specific design concepts that make Ocoee Middle School the SMART school of the future while also controlling design and construction costs are examined. (GR)

Optimal Selection of Time Series Coefficients for Wrist Myoelectric Control Based on Intramuscular Recordings

DTIC Science & Technology

2001-10-25

considered static or invariant because the spectral behavior of EMG data is dependent on the specific muscle , contraction level, and limb function. However...produced at the onset of the muscle contraction . Because the units with lower conduction velocity (lower frequency components) are recruited first, the

Expert System Initiative in Logistic Readiness (EXSYN)

DTIC Science & Technology

1987-03-01

reduce the number of cooks. Specific units are designated "feeders" and have kitchen equipment to fulfill this mission. X. (QM) Emphasis is placed on...the conduct of the unit mission. Within the A-level especially critical items are disigned are pacing items or ERC-P. ERC-P equipment of the

Children's Recall and Recognition of Sex Role Stereotyped and Discrepant Information.

ERIC Educational Resources Information Center

Trepanier-Street, Mary L.; Kropp, Jerri Jaudon

Two studies were conducted to investigate the influence of differing levels of sex role stereotyped and discrepant information on the immediate and delayed memory of young children. Specifically, kindergarten and 2nd-grade children's recall and recognition of stereotyped, moderately discrepant, and highly discrepant pictures were compared. In…

Species-specific control of external superoxide levels by the coral holobiont during a natural bleaching event

NASA Astrophysics Data System (ADS)

Diaz, Julia M.; Hansel, Colleen M.; Apprill, Amy; Brighi, Caterina; Zhang, Tong; Weber, Laura; McNally, Sean; Xun, Liping

2016-12-01

The reactive oxygen species superoxide (O2.-) is both beneficial and detrimental to life. Within corals, superoxide may contribute to pathogen resistance but also bleaching, the loss of essential algal symbionts. Yet, the role of superoxide in coral health and physiology is not completely understood owing to a lack of direct in situ observations. By conducting field measurements of superoxide produced by corals during a bleaching event, we show substantial species-specific variation in external superoxide levels, which reflect the balance of production and degradation processes. Extracellular superoxide concentrations are independent of light, algal symbiont abundance and bleaching status, but depend on coral species and bacterial community composition. Furthermore, coral-derived superoxide concentrations ranged from levels below bulk seawater up to ~120 nM, some of the highest superoxide concentrations observed in marine systems. Overall, these results unveil the ability of corals and/or their microbiomes to regulate superoxide in their immediate surroundings, which suggests species-specific roles of superoxide in coral health and physiology.

Field test of the superconducting gravimeter as a hydrologic sensor.

PubMed

Wilson, Clark R; Scanlon, Bridget; Sharp, John; Longuevergne, Laurent; Wu, Hongqiu

2012-01-01

We report on a field test of a transportable version of a superconducting gravimeter (SG) intended for groundwater storage monitoring. The test was conducted over a 6-month period at a site adjacent to a well in the recharge zone of the karstic Edwards Aquifer, a major groundwater resource in central Texas. The purpose of the study was to assess requirements for unattended operation of the SG in a field setting and to obtain a gravimetric estimate of aquifer specific yield. The experiment confirmed successful operation of the SG, but water level changes were small (<0.3 m) leading to uncertainty in the estimate of specific yield. Barometric pressure changes were the dominant cause of both water level variations and non-tidal gravity changes. The specific yield estimate (0.26) is larger than most published values and dependent mainly on low frequency variations in residual gravity and water level time series. © 2011, The Author(s). Ground Water © 2011, National Ground Water Association.

Levels of conflict in reasoning modulate right lateral prefrontal cortex.

PubMed

Stollstorff, Melanie; Vartanian, Oshin; Goel, Vinod

2012-01-05

Right lateral prefrontal cortex (rlPFC) has previously been implicated in logical reasoning under conditions of conflict. A functional magnetic resonance imaging (fMRI) study was conducted to explore its role in conflict more precisely. Specifically, we distinguished between belief-logic conflict and belief-content conflict, and examined the role of rlPFC under each condition. The results demonstrated that a specific region of rlPFC is consistently activated under both types of conflict. Moreover, the results of a parametric analysis demonstrated that the same region was modulated by the level of conflict contained in reasoning arguments. This supports the idea that this specific region is engaged to resolve conflict, including during deductive reasoning. This article is part of a Special Issue entitled "The Cognitive Neuroscience of Thought". Copyright © 2011 Elsevier B.V. All rights reserved.

Empirical likelihood-based confidence intervals for the sensitivity of a continuous-scale diagnostic test at a fixed level of specificity.

PubMed

Gengsheng Qin; Davis, Angela E; Jing, Bing-Yi

2011-06-01

For a continuous-scale diagnostic test, it is often of interest to find the range of the sensitivity of the test at the cut-off that yields a desired specificity. In this article, we first define a profile empirical likelihood ratio for the sensitivity of a continuous-scale diagnostic test and show that its limiting distribution is a scaled chi-square distribution. We then propose two new empirical likelihood-based confidence intervals for the sensitivity of the test at a fixed level of specificity by using the scaled chi-square distribution. Simulation studies are conducted to compare the finite sample performance of the newly proposed intervals with the existing intervals for the sensitivity in terms of coverage probability. A real example is used to illustrate the application of the recommended methods.

Aquifer test to determine hydraulic properties of the Elm aquifer near Aberdeen, South Dakota

USGS Publications Warehouse

Schaap, Bryan D.

2000-01-01

The Elm aquifer, which consists of sandy and gravelly glacial-outwash deposits, is present in several counties in northeastern South Dakota. An aquifer test was conducted northeast of Aberdeen during the fall of 1999 to determine the hydraulic properties of the Elm aquifer in that area. An improved understanding of the properties of the aquifer will be useful in the possible development of the aquifer as a water resource. Historical water-level data indicate that the saturated thickness of the Elm aquifer can change considerably over time. From September 1977 through November 1985, water levels at three wells completed in the Elm aquifer near the aquifer test site varied by 5.1 ft, 9.50 ft, and 11.1 ft. From June 1982 through October 1999, water levels at five wells completed in the Elm aquifer near the aquifer test site varied by 8.7 ft, 11.4 ft, 13.2 ft, 13.8 ft, and 19.7 ft. The water levels during the fall of 1999 were among the highest on record, so the aquifer test was affected by portions of the aquifer being saturated that might not be saturated during drier times. The aquifer test was conducted using five existing wells that had been installed prior to this study. Well A, the pumped well, has an operating irrigation pump and is centrally located among the wells. Wells B, C, D, and E are about 70 ft, 1,390 ft, 2,200 ft, and 3,100 ft, respectively, in different directions from Well A. Using vented pressure transducers and programmable data loggers, water-level data were collected at the five wells prior to, during, and after the pumping, which started on November 19, 1999, and continued a little over 72 hours. Based on available drilling logs, the Elm aquifer near the test area was assumed to be unconfined. The Neuman (1974) method theoretical response curves that most closely match the observed water-level changes at Wells A and B were calculated using software (AQTESOLV for Windows Version 2.13-Professional) developed by Glenn M. Duffield of HydroSOLVE, Inc. These best fit theoretical response curves are based on a transmissivity of 24,000 ft2/d or a hydraulic conductivity of about 600 ft/d, a storage coefficient of 0.05, a specific yield of 0.42, and vertical hydraulic conductivity equal to horizontal hydraulic conductivity. The theoretical type curves match the observed data fairly closely at Wells A and B until about 2,500 minutes and 1,000 minutes, respectively, after pumping began. The increasing rate of drawdown after these breaks is an indication that a no-flow boundary (an area with much lower hydraulic conductivity) likely was encountered and that Wells A and B may be completed in a part of the Elm aquifer with limited hydraulic connection to the rest of the aquifer. Additional analysis indicates that if different assumptions regarding the screened interval for Well B and aquifer anisotropy are used, type curves can be calculated that fit the observed data using a lower specific yield that is within the commonly accepted range. When the screened interval for Well B was reduced to 5 ft near the top of the aquifer and horizontal hydraulic conductivity was set to 20 times vertical hydraulic conductivity, the type curves calculated using a specific yield of 0.1 and a transmissivity of 30,200 ft2/d also matched the observed data from Wells A and B fairly well. A version of the Theim equilibrium equation was used to calculate the theoretical drawdown in an idealized unconfined aquifer when a perfectly efficient well is being pumped at a constant rate. These calculations were performed for a range of pumping rates, drawdowns at the wells, and distances between wells that might be found in a production well field in the Elm aquifer. Although the aquifer test indicates that hydraulic conductivity near the well may be adequate to support a production well, the comparison of drawdown and recovery curves indicates the possibility that heterogeneities may limit the productive capacity of specific loca

Study, selection, and preparation of solid cationic conductors. [characteristics of solid electrolytes for rechargeable high energy and high power density batteries

NASA Technical Reports Server (NTRS)

Roth, W. L.; Muller, O.

1974-01-01

Crystal chemical principles and transport theory have been used to predict structures and specific compounds which might find application as solid electrolytes in rechargeable high energy and high power density batteries operating at temperatures less than 200 C. Structures with 1-, 2-, and 3-dimensional channels were synthesized and screened by nuclear magnetic resonance, dielectric loss, and conductivity. There is significant conductivity at room temperature in some of the materials but none attain a level that is comparable to beta-alumina. Microwave and fast pulse methods were developed to measure conductivity in powders and in small crystals.

Size dependent polaronic conduction in hematite

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sharma, Monika; Banday, Azeem; Murugavel, Sevi

2016-05-23

Lithium Ion Batteries have been attracted as the major renewable energy source for all portable electronic devices because of its advantages like superior energy density, high theoretical capacity, high specific energy, stable cycling and less memory effects. Recently, α-Fe{sub 2}O{sub 3} has been considered as a potential anode material due to high specific capacity, low cost, high abundance and environmental benignity. We have synthesized α-Fe{sub 2}O{sub 3} with various sizes by using the ball milling and sol-gel procedure. Here, we report the dc conductivity measurement for the crystallite size ranging from 15 nm to 50 nm. It has been observedmore » that the enhancement in the polaronic conductivity nearly two orders in magnitude while reducing the crystallite size from bulk into nano scale level. The enhancement in the conductivity is due to the augmented to compressive strain developed in the material which leads to pronounced decrease in the hopping length of polarons. Thus, nanocrystaline α-Fe{sub 2}O{sub 3} may be a better alternative anode material for lithium ion batteries than earlier reported systems.« less

Analysis of groundwater response to tidal fluctuations, Operable Unit 2, Area 8, Naval Base Kitsap, Keyport, Washington

USGS Publications Warehouse

Opatz, Chad C.; Dinicola, Richard S.

2018-05-21

Operable Unit 2, Area 8, at Naval Base Kitsap, Keyport is the site of a former chrome-plating facility that released metals (primarily chromium and cadmium), chlorinated volatile organic compounds, and petroleum compounds into the local environment. To ensure long-term protectiveness, as stipulated in the Fourth Five-Year Review for the site, Naval Facilities Engineering Command Northwest collaborated with the U.S. Environmental Protection Agency, the Washington State Department of Ecology, and the Suquamish Tribe, to collect data to monitor the contamination left in place and to ensure the site does not pose a risk to human health or the environment. To support these efforts, refined information was needed on the interaction of fresh groundwater with seawater in response to the up-to 13-ft tidal fluctuations at this nearshore site adjacent to Port Orchard Bay. The information was analyzed to meet the primary objective of this investigation, which was to determine the optimal time during the semi-diurnal and the neap-spring tidal cycles to sample groundwater for freshwater contaminants in Area 8 monitoring wells.Groundwater levels and specific conductance in five monitoring wells, along with marine water-levels (tidal levels) in Port Orchard Bay, were monitored every 15 minutes during a 3-week duration to determine how nearshore groundwater responds to tidal forcing. Time series data were collected from October 24, 2017, to November 16, 2017, a period that included neap and spring tides. Vertical profiles of specific conductance were also measured once in the screened interval of each well prior to instrument deployment to determine if a freshwater/saltwater interface was present in the well during that particular time.The vertical profiles of specific conductance were measured only one time during an ebbing tide at approximately the top, middle, and bottom of the saturated thickness within the screened interval of each well. The landward-most well, MW8-8, was completely freshwater, while one of the most seaward wells, MW8-9, was completely saline. A distinct saltwater interface was measured in the three other shallow wells (MW8-11, MW8-12, and MW8-14), with the topmost groundwater occurring fresh underlain by higher conductivity water.Lag times between minimum spring-tide level and minimum groundwater levels in wells ranged from about 2 to 4.5 hours in the less-than 20-ft deep wells screened across the water table, and was about 7 hours for the single 48-ft deep well screened below the water table. Those lag times were surprisingly long considering the wells are all located within 200-ft of the shoreline and the local geology is largely coarse-grained glacial outwash deposits. Various manmade subsurface features, such as slurry walls and backfilled excavations, likely influence and confuse the connectivity between seawater and groundwater.The specific-conductance time-series data showed clear evidence of substantial saltwater intrusion into the screened intervals of most shallow wells. Unexpectedly, the intrusion was associated with the neap part of the tidal cycle around November 13–16, when relatively low barometric pressure and high southerly winds led to the highest high and low tides measured during the monitoring period. The data consistently indicated that the groundwater had the lowest specific conductance (was least mixed with seawater) during the prior neap tides around October 30, the same period when the shallow groundwater levels were lowest. Although the specific conductance response is somewhat different between wells, the data do suggest that it is the heights of the actual high-high and low-low tides, regardless of whether or not they occur during the neap or spring part of the cycle, that allows seawater intrusion into the nearshore aquifer at Area 8.With all the data taken into consideration, the optimal time for sampling the shallow monitoring wells at Area 8 would be centered on a 2–5-hour period following the predicted low-low tide during neap tide, with due consideration of local atmospheric pressure and wind conditions that have the potential to generate tides that can be substantially higher than those predicted from lunar-solar tidal forces. The optimal time for sampling the deeper monitoring wells at Area 8 would be during the 6–8-hour period following a predicted low-low tide, also during the neap tide part of the tidal cycle. The specific time window to sample each well following a low tide can be found in table 5. Those periods are when groundwater in the wells is most fresh and least diluted by seawater intrusion. In addition to timing, consideration should be given to collecting undisturbed samples from the top of the screened interval (or top of the water table if below the top of the interval) to best characterize contaminant concentrations in freshwater. A downhole conductivity probe could be used to identify the saltwater interface, above which would be the ideal depth for sampling.

Status of water levels and selected water-quality conditions in the Sparta-Memphis aquifer in Arkansas, Spring-Summer 2003

USGS Publications Warehouse

Schrader, T.P.

2006-01-01

During the spring of 2003, water levels were measured in 341 wells in the Sparta-Memphis aquifer in Arkansas. Waterquality samples were collected for temperature and specificconductance measurements during the spring-summer of 2003 from 70 wells in Arkansas in the Sparta-Memphis aquifer. Maps of areal distribution of potentiometric surface, change in waterlevel measurements from 1999 to 2003, and specific-conductance data reveal spatial trends across the study area. The highest water-level altitude measured in Arkansas was 328 feet above National Geodetic Vertical Datum of 1929 (NGVD of 1929) in Craighead County; the lowest water-level altitude was 199 feet below NGVD of 1929 in Union County. Three large cones of depression are shown in the 2003 potentiometric surface map, centered in Columbia, Jefferson, and Union Counties in Arkansas as a result of large withdrawals for industrial and public supplies. A broad depression exists in western Poinsett County in Arkansas. The potentiometric surface indicates that large withdrawals have altered or reversed the natural direction of flow in most areas. In the northern third of the study area the flow is from the east, west, and north towards the broad depression in Poinsett County. In the central third of the study area the flow is dominated by the cone of depression centered in Jefferson County. In the southern third of the study area the flow is dominated by the two cones of depression in Union and Columbia Counties. A map of water-level changes from 1999 to 2003 was constructed using water-level measurements from 281 wells. The largest rise in water level measured was about 57.8 feet in Columbia County. The largest decline in water level measured was about -71.6 feet in Columbia County. Areas with a general rise are shown in Arkansas, Bradley, Calhoun, Cleveland, Columbia, Ouachita, and Union Counties. Areas with a general decline are shown in Craighead, Crittenden, Cross, Desha, Drew, Jefferson, Lonoke, Phillips, Poinsett, Prairie, and Woodruff Counties. Hydrographs were constructed for wells with a minimum of 25 years of water-level measurements. A trend line using a linear regression was calculated for the period of record from spring of 1978 to spring of 2003 to determine the annual decline or rise in feet per year for water levels in each well. The hydrographs were grouped by county. The mean values for county annual water-level decline or rise ranged from -1.42 to 0.27 foot per year. Specific conductance ranged from 82 microsiemens per centimeter at 25 degrees Celsius in Jefferson County to about 1,210 microsiemens per centimeter at 25 degrees Celsius in Lee County. The mean specific conductance was 400 microsiemens per centimeter at 25 degrees Celsius.

Do xylem fibers affect vessel cavitation resistance?

PubMed

Jacobsen, Anna L; Ewers, Frank W; Pratt, R Brandon; Paddock, William A; Davis, Stephen D

2005-09-01

Possible mechanical and hydraulic costs to increased cavitation resistance were examined among six co-occurring species of chaparral shrubs in southern California. We measured cavitation resistance (xylem pressure at 50% loss of hydraulic conductivity), seasonal low pressure potential (P(min)), xylem conductive efficiency (specific conductivity), mechanical strength of stems (modulus of elasticity and modulus of rupture), and xylem density. At the cellular level, we measured vessel and fiber wall thickness and lumen diameter, transverse fiber wall and total lumen area, and estimated vessel implosion resistance using (t/b)(h)(2), where t is the thickness of adjoining vessel walls and b is the vessel lumen diameter. Increased cavitation resistance was correlated with increased mechanical strength (r(2) = 0.74 and 0.76 for modulus of elasticity and modulus of rupture, respectively), xylem density (r(2) = 0.88), and P(min) (r(2) = 0.96). In contrast, cavitation resistance and P(min) were not correlated with decreased specific conductivity, suggesting no tradeoff between these traits. At the cellular level, increased cavitation resistance was correlated with increased (t/b)(h)(2) (r(2) = 0.95), increased transverse fiber wall area (r(2) = 0.89), and decreased fiber lumen area (r(2) = 0.76). To our knowledge, the correlation between cavitation resistance and fiber wall area has not been shown previously and suggests a mechanical role for fibers in cavitation resistance. Fiber efficacy in prevention of vessel implosion, defined as inward bending or collapse of vessels, is discussed.

Carrier Transport and Effective Barrier Height of Low Resistance Metal Contact to Highly Mg-Doped p-GaN

NASA Astrophysics Data System (ADS)

Park, Youngjun; Kim, Hyunsoo

2011-08-01

The effective barrier height and carrier transport mechanism of low resistance Ag-based contact to highly Mg-doped p-GaN were investigated. The specific contact resistance obtained was as low as 7.0×10-4 Ω cm2. The electrical resistivity of p-GaN was found to increase depending on ˜T-1/4, indicating variable-range hopping (VRH) conduction through Mg-related deep-level defects. Based on the VRH conduction model, the effective barrier height for carrier transport could be measured as 0.12 eV, which is low enough to explain the formation of excellent ohmic contact. The deep-level defects were also found to induce surface Fermi pinning.

Specific IgE in tear fluid and features of allergic conjunctivitis.

PubMed

Mimura, Tatsuya; Yamagami, Satoru; Kamei, Yuko; Goto, Mari; Matsubara, Masao

2013-09-01

The level of specific class E immunoglobulins (IgE) in tear fluid is a useful diagnostic indicator for allergic conjunctivitis, but it is still unclear whether the measurement of tear fluid IgE is helpful for assessing the severity of allergic conjunctivitis. In this study, we evaluated the relation between tear fluid levels of specific IgE and features of allergic conjunctivitis. A prospective, nonrandomized, cross-sectional study was conducted in patients with allergic conjunctivitis (n = 55, allergic group) and age- and sex-matched healthy control subjects (n = 50, control group). Levels of specific IgE for cedar pollen, cat epithelium/dander and Dermatophagoides pteronyssinus were measured in tear fluid with the Immfast Check J1®. A severity score (0, 1, 2 or 3) was assigned for various changes of the palpebral and bulbar conjunctiva, as well as for limbal and corneal lesions. The levels of specific IgE for both cedar pollen, and D. pteronyssinus were significantly higher in the allergic group compared with the control group (p < 0.0001), while the level of specific IgE for cat epithelium/dander showed no significant difference between the two groups (p = 0.0777). When IgE levels were divided into four classes, the classes for both D. Pteronyssinus and cat epithelium/dander IgE were correlated with four features of allergic conjunctivitis. On the other hand, no correlation was found between the class of cedar pollen IgE and any of the features of allergic conjunctivitis. This study demonstrated that measurement of specific IgE in tear fluid may be useful for determining the severity of allergic conjunctivitis induced by indoor allergens. Although measurement of IgE in tear fluid is only a supplemental tool for evaluating the clinical activity of allergic conjunctivitis, the test can be useful for detecting specific IgE antibodies responsible for this condition.

Correlations of carotenoid content and transcript abundances for fibrillin and carotenogenic enzymes in Capsicum annum fruit pericarp.

PubMed

Kilcrease, James; Rodriguez-Uribe, Laura; Richins, Richard D; Arcos, Juan Manuel Garcia; Victorino, Jesus; O'Connell, Mary A

2015-03-01

The fruits of Capsicum spp. are especially rich sites for carotenoid synthesis and accumulation, with cultivar-specific carotenoid accumulation profiles. Differences in chromoplast structure as well as carotenoid biosynthesis are correlated with distinct carotenoid accumulations and fruit color. In the present study, the inheritance of chromoplast shape, carotenoid accumulation profiles, and transcript levels of four genes were measured. Comparisons of these traits were conducted using fruit from contrasting variants, Costeño Amarillo versus Costeño Red, and from F1 hybrids; crosses between parental lines with novel versions of these traits. Intermediate chromoplast shapes were observed in the F1, but no association between specific carotenoid accumulation and chromoplast shape was detected. Increased total carotenoid content was associated with increased β-carotene and violaxanthin content. Transcript levels for phytoene synthase (Psy) and β-carotene hydroxylase (CrtZ-2) were positively correlated with increased levels of specific carotenoids. No correlation was detected between transcript levels of capsanthin/capsorubin synthase (Ccs) and carotenoid composition or chromoplast shape. Transcript levels of fibrillin, were differentially correlated with specific carotenoids, negatively correlated with accumulation of capsanthin, and positively correlated with violaxanthin. The regulation of carotenoid accumulation in chromoplasts in Capsicum fruit continues to be a complex process with multiple steps for control. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Modelling (18)O2 and (16)O2 unidirectional fluxes in plants. IV: role of conductance and laws of its regulation in C3 plants.

PubMed

André, Marcel J

2013-08-01

Numerous studies focus on the measurement of conductances for CO2 transfer in plants and especially on their regulatory effects on photosynthesis. Measurement accuracy is strongly dependent on the model used and on the knowledge of the flow of photochemical energy generated by light in chloroplasts. The only accurate and precise method to quantify the linear electron flux (responsible for the production of reductive energy) is the direct measurement of O2 evolution, by (18)O2 labelling and mass spectrometry. The sharing of this energy between the carboxylation (P) and the oxygenation of photorespiration (PR) depends on the plant specificity factor (Sp) and on the corresponding atmospheric concentrations of CO2 and O2 (André, 2013). The concept of plant specificity factor simplifies the equations of the model. It gives a new expression of the effect of the conductance (g) between atmosphere and chloroplasts. Its quantitative effect on photosynthesis is easy to understand because it intervenes in the ratio of the plant specificity factor (Sp) to the specificity of Rubisco (Sr). Using this 'simple' model with the data of (18)O2 experiments, the calculation of conductance variations in response to CO2 and light was carried out. The good fitting of experimental data of O2 and CO2 exchanges confirms the validity of the simple model. The calculation of conductance variation during the increase of external CO2 concentration reveals a linear law of regulation between external and internal CO2 concentrations. During CO2 variations, the effects of g regulation tend to maintain a higher level of oxygenation (PR) in expense of a better carboxylation (P). Contrary to CO2, the variation of O2 creates a negative feedback effect compatible with a stabilization of atmospheric O2. The regulation of g amplifies this result. The effect of light in combination with CO2 is more complex. Below 800μmolquantam(-2)s(-1) the ratio PR/P is maintained unchangeable in expense of carboxylation efficiency. Above that irradiance value, PR/P increases dramatically. It appears that the saturation curves of photosynthesis under high light could be simply due to the regulation by the conductance g and not by any biochemical or biophysical limitation. In conclusion, the regulatory effect of conductance operates in a way that it preserves the rate of photorespiration. This confirms a positive and protective role of photorespiration at the biochemical, whole plant and atmosphere levels. Since the effects of photorespiration are linked to the properties of Rubisco, they add new arguments for a co-evolution of plant and atmosphere, including the evolution of CO2 conductance. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Manage habitat, monitor species [Chapter 10

Treesearch

Michael K. Schwartz; Jamie S. Sanderlin; William M. Block

2015-01-01

Monitoring is the collection of data over time. We monitor many things: temperatures at local weather stations, daily changes in sea level along the coastline, annual prevalence of specific diseases, sunspot cycles, unemployment rates, inflation, commodity futures-the list is virtually endless. In wildlife biology, we also conduct a lot of monitoring, most commonly...

Assessment of Differences in University Oceanography Students' Scientific Writing.

ERIC Educational Resources Information Center

Takao, Allison Y.; Kelly, Gregory J.

The purpose of this paper is to assess the differences in university oceanography students' scientific writing. Specifically, the authors examine the argumentation structures of a high scoring paper and a low scoring paper. This study was conducted in an introductory level oceanography course in a large public university. In this course students…

Parenting Styles as They Relate to Self-Esteem and Adjustment.

ERIC Educational Resources Information Center

Sigward, Timothy M.; And Others

This study was conducted to examine the relationships between parental styles and the components of self-esteem that correspond to Damon and Hart's conceptualization of the self. Specifically, high levels of both parental control and parent acceptance were hypothesized to be positively related to self-esteem. Undergraduate students (N=225) rated…

A Portrayal of Women Educational Leadership in Pakistan

ERIC Educational Resources Information Center

Malik, Samina

2011-01-01

The researcher is stimulated to work on the growing trends of women leadership. The problem has been designed to investigate the factors influencing the emergence of women leadership at higher education level in Pakistan. On the basis of the studies conducted by Oplatka (2006) and Cubillo, Brown, 2003, it was assumed that specific factors…

Basic Training Program for Emergency Medical Technician Ambulance: Course Guide.

ERIC Educational Resources Information Center

Fucigna, Joseph T.; And Others

In an effort to upgrade or further develop the skills levels of all individuals involved in the emergency medical care service, this training program was developed for the National Highway Safety Bureau. This specific course is an attempt to organize, conduct, and standardize a basic training course for emergency medical technicians (EMTs). The…

Working Memory and Language: Skill-Specific or Domain-General Relations to Mathematics?

ERIC Educational Resources Information Center

Purpura, David J.; Ganley, Colleen M.

2014-01-01

Children's early mathematics skills develop in a cumulative fashion; foundational skills form a basis for the acquisition of later skills. However, non-mathematical factors such as working memory and language skills have also been linked to mathematical development at a broad level. Unfortunately, little research has been conducted to evaluate the…

Women in Educational Leadership within the Tamale Metropolis

ERIC Educational Resources Information Center

Segkulu, L.; Gyimah, K.

2016-01-01

Within the Tamale Metropolis, it is observed that only a few women occupy top level management positions within the Ghana Education Service (GES). A descriptive survey was therefore conducted in 2013/2014 academic year to assess the factors affecting the gender disparity in educational leadership within the Service. Specifically, the study sought…

Inquiry Skills: A Phenomenological Study on the Perceptions of First-Year Community College Students

ERIC Educational Resources Information Center

Donaldson, Audrey

2012-01-01

The purpose of this qualitative hermeneutic phenomenological study was to explore the specific factors associated with inquiry skills as a component of success with college level coursework. A hermeneutic phenomenological study was conducted to gain an understanding based on interview responses to questions about learning experiences as perceived…

Constituent Perceptions of a Community College: An "Image" Study.

ERIC Educational Resources Information Center

Conklin, Karen A.

Every 5 years, Johnson County Community College (JCCC), in Overland Park, Kansas, conducts a study of community perceptions to measure the level of community satisfaction with the overall mission of the college. Specifically, the studies seek to measure constituents' awareness of JCCC's role, their support of the college's activities to fulfill…

The Missing Link: Service-Learning as an Essential Tool for Correctional Education

ERIC Educational Resources Information Center

Frank, Jacquelyn B.; Omstead, Jon-Adam; Pigg, Steven Anthony

2012-01-01

This article reports the results of a Participatory Action Research (PAR) study conducted by a university faculty member and two incarcerated college graduates in Indiana. The research team designed and piloted a service-learning program specifically aimed at college-level inmates in a maximum security prison. This qualitative study used…

Controlled environment life support system: Growth studies with potatoes

NASA Technical Reports Server (NTRS)

Tibbitts, T. W.; Wheeler, R. M.

1986-01-01

Results of experiments conducted to maximize the productivity of potatoes grown under controlled environmental conditions are discussed. A variety of parameters is examined which affect potato growth, specifically, photoperiod, light intensity, temperature, nitrogen nutrition, carbon dioxide concentration and culture techniques. These experiments were conducted using five different cultivars, Russet Burbank, Norchip, Superior, Kennebec and Norland. To achieve high productivity, three specific objectives were explored: (1) to develop effective cultural procedures, (2) to determine the most effective photoperiod and (3) to develop a mist culture system. It is felt that the productivity obtained in this study is below the maximum that can be obtained. High irradiance levels coupled with tuber-promoting conditions such as cooler temperatures, increased CO2 levels and lowered nitrogen concentrations should allow increases in tuber production. Tuberization appears to be accelerated by short daylengths although final yields are not increased. Mist culture techniques have not yet produced fully developed tubers. The use of supporting media and alteration of the nitrogen content of the mist solution are being explored as a way to allow tubers to develop to maturity.

Hydrologic conditions, recharge, and baseline water quality of the surficial aquifer system at Jekyll Island, Georgia, 2012-13

USGS Publications Warehouse

Gordon, Debbie W.; Torak, Lynn J.

2016-03-08

Groundwater levels and specific-conductance measurements showed the dependence of freshwater resources on rainfall to recharge the water-table zone of the surficial aquifer system and to influence groundwater flow on Jekyll Island. The unseasonably dry conditions during November 2012 to April 2013 induced saline water infiltration to the water-table zone from the marshland separating the Jekyll River from the island. A strong correlation (R2 = 0.97) of specific conductance to chloride concentration in water samples from wells installed in the water-table zone provided support for the determination of seasonal directions of groundwater flow by confirming salinity changes in the water-table zone. Unseasonably wet conditions during the late spring to August caused groundwater-flow reversals in some areas. The high dependence of the water-table zone in the surficial aquifer system on precipitation to replenish the aquifer with freshwater underscored the importance of monitoring groundwater levels, water quality, and water use to identify aquifer-discharge conditions that have the potential to promote seawater encroachment and degrade freshwater resources on Jekyll Island.

Revisiting the origin of satellites in core-level photoemission of transparent conducting oxides: The case of n -doped SnO2

NASA Astrophysics Data System (ADS)

Borgatti, Francesco; Berger, J. A.; Céolin, Denis; Zhou, Jianqiang Sky; Kas, Joshua J.; Guzzo, Matteo; McConville, C. F.; Offi, Francesco; Panaccione, Giancarlo; Regoutz, Anna; Payne, David J.; Rueff, Jean-Pascal; Bierwagen, Oliver; White, Mark E.; Speck, James S.; Gatti, Matteo; Egdell, Russell G.

2018-04-01

The longstanding problem of interpretation of satellite structures in core-level photoemission spectra of metallic systems with a low density of conduction electrons is addressed using the specific example of Sb-doped SnO2. Comparison of ab initio many-body calculations with experimental hard x-ray photoemission spectra of the Sn 4 d states shows that strong satellites are produced by coupling of the Sn core hole to the plasma oscillations of the free electrons introduced by doping. Within the same theoretical framework, spectral changes of the valence band spectra are also related to dynamical screening effects. These results demonstrate that, for the interpretation of electron correlation features in the core-level photoelectron spectra of such narrow-band materials, going beyond the homogeneous electron gas electron-plasmon coupling model is essential.

Electrochemical probing of high-level radioactive waste tanks containing washed sludge and precipitates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bickford, D.F.; Congdon, J.W.; Oblath, S.B.

1987-01-01

At the U.S. Department of Energy's Savannah River Plant, corrosion of carbon steel storage tanks containing alkaline, high-level radioactive waste is controlled by specification of limits on waste composition and temperature. Processes for the preparation of waste for final disposal will result in waste with low corrosion inhibitor concentrations and, in some cases, high aromatic organic concentrations, neither of which are characteristic of previous operations. Laboratory tests, conducted to determine minimum corrosion inhibitor levels indicated pitting of carbon steel near the waterline for proposed storage conditions. In situ electrochemical measurements of full-scale radioactive process demonstrations have been conducted to assessmore » the validity of laboratory tests. Probes included pH, Eh (potential relative to a standard hydrogen electrode), tank potential, and alloy coupons. In situ results are compared to those of the laboratory tests, with particular regard given to simulated solution composition.« less

Role of specific IgE and skin-prick testing in predicting food challenge results to baked egg.

PubMed

Cortot, Catherine F; Sheehan, William J; Permaul, Perdita; Friedlander, James L; Baxi, Sachin N; Gaffin, Jonathan M; Dioun, Anahita F; Hoffman, Elaine B; Schneider, Lynda C; Phipatanakul, Wanda

2012-01-01

Previous studies suggest that children with egg allergy may be able to tolerate baked egg. Reliable predictors of a successful baked egg challenge are not well established. We examined egg white-specific IgE levels, skin-prick test (SPT) results, and age as predictors of baked egg oral food challenge (OFC) outcomes. We conducted a retrospective chart review of children, aged 2-18 years, receiving an egg white-specific IgE level, SPT, and OFC to baked egg from 2008 to 2010. Fifty-two oral baked egg challenges were conducted. Of the 52 challenges, 83% (n = 43) passed and 17% (n = 9) failed, including 2 having anaphylaxis. Median SPT wheal size was 12 mm (range, 0-35 mm) for passed challenges and 17 mm (range, 10-30 mm) for failed challenges (p = 0.091). The negative predictive value for passing the OFC was 100% (9 of 9) if SPT wheal size was <10 mm. Median egg white-specific IgE was 2.02 kU/L (range, <0.35-13.00 kU/L) for passed challenges and 1.52 kU/L (range, 0.51-6.10 kU/L) for failed challenges (p = 0.660). Receiver operating characteristic (ROC) curve analysis for SPT revealed an area under the curve (AUC) of 0.64. ROC curve analysis for egg white-specific IgE revealed an AUC of 0.63. There was no significant difference in age between patients who failed and those who passed (median = 8.8 years versus 7.0 years; p = 0.721). Based on our sample, SPT, egg white-specific IgE and age are not good predictors of passing a baked egg challenge. However, there was a trend for more predictability with SPT wheal size.

A study on the influence of tides on the water table conditions of the shallow coastal aquifers

NASA Astrophysics Data System (ADS)

Singaraja, C.; Chidambaram, S.; Jacob, Noble

2018-03-01

Tidal variation and water level in aquifer is an important function in the coastal environment, this study attempts to find the relationship between water table fluctuation and tides in the shallow coastal aquifers. The study was conducted by selecting three coastal sites and by monitoring the water level for every 2-h interval in 24 h of observation. The study was done during two periods of full moon and new moon along the Cuddalore coastal region of southern part of Tamil Nadu, India. The study shows the relationship between tidal variation, water table fluctuations, dissolved oxygen, and electrical conductivity. An attempt has also been made in this study to approximate the rate of flow of water. Anyhow, the differences are site specific and the angle of inclination of the water table shows a significant relation to the mean sea level, with respect to the distance of the point of observation from the sea and elevation above mean sea level.

Electrical and thermal characteristics of Bi2212/Ag HTS coils for conduction-cooled SMES

NASA Astrophysics Data System (ADS)

Hayakawa, N.; Noguchi, S.; Kurupakorn, C.; Kojima, H.; Endo, F.; Hirano, N.; Nagaya, S.; Okubo, H.

2006-06-01

In this paper, we investigated the electrical and thermal performance of conduction-cooled Bi2212/Ag HTS coils with 4K-GM cryocooler system. First, we measured the critical current Ic for different ambient temperatures T0 at 4.2 K - 40 K. Experimental results revealed that Ic increased with the decrease in T0 and was saturated at T0 < 10 K. We carried out thermal analysis considering heat generation, conduction and transfer under conduction-cooling condition, and reproduced the electrical and thermal characteristics of the conduction-cooled HTS coil, taking account of temperature dependence of specific heat and thermal conductivity of the materials. We also measured the temperature rise of Bi2212/Ag HTS coil for different continuous current levels at T0 = 4.8 K. Experimental results revealed the criterion of thermal runaway, which was discussed in terms of heat generation and propagation in the test coil.

Impact of Multifunctional Bimetallic Materials on Lithium Battery Electrochemistry.

PubMed

Durham, Jessica L; Poyraz, Altug S; Takeuchi, Esther S; Marschilok, Amy C; Takeuchi, Kenneth J

2016-09-20

Electric energy storage devices such as batteries are complex systems comprised of a variety of materials with each playing separate yet interactive roles, complicated by length scale interactions occurring from the molecular to the mesoscale. Thus, addressing specific battery issues such as functional capacity requires a comprehensive perspective initiating with atomic level concepts. For example, the electroactive materials which contribute to the functional capacity in a battery comprise approximately 30% or less of the total device mass. Thus, the design and implementation of multifunctional materials can conceptually reduce or eliminate the contribution of passive materials to the size and mass of the final system. Material multifunctionality can be achieved through appropriate material design on the atomic level resulting in bimetallic electroactive materials where one metal cation forms mesoscale conductive networks upon discharge while the other metal cations can contribute to atomic level structure and net functional secondary capacity, a device level issue. Specifically, this Account provides insight into the multimechanism electrochemical redox processes of bimetallic cathode materials based on transition metal oxides (MM'O) or phosphorus oxides (MM'PO) where M = Ag and M' = V or Fe. One discharge process can be described as reduction-displacement where Ag(+) is reduced to Ag(0) and displaced from the parent structure. This reduction-displacement reaction in silver-containing bimetallic electrodes allows for the in situ formation of a conductive network, enhancing the electrochemical performance of the electrode and reducing or eliminating the need for conductive additives. A second discharge process occurs through the reduction of the second transition metal, V or Fe, where the oxidation state of the metal center is reduced and lithium cations are inserted into the structure. As both metal centers contribute to the functional capacity, determining the kinetically and thermodynamically preferred reduction processes at various states of discharge is critical to elucidating the mechanism. Specific advanced in situ and ex situ characterization techniques are conducive to gaining insight regarding the electrochemical behavior of these multifunctional materials over multiple length scales. At the material level, optical microscopy, scanning electron microscopy, and local conductivity measurement via a nanoprobe can track the discharge mechanism of an isolated single particle. At the mesoscale electrode level, in situ data from synchrotron based energy dispersive X-ray diffraction (EDXRD) within fully intact steel batteries can be used to spatially map the distribution of silver metal generated through reduction displacement as a function of discharge depth and discharge rate. As illustrated here, appropriate design of materials with multiple electrochemically active metal centers and properties tuned through strategically conceptualized materials synthesis may provide a path toward the next generation of high energy content electroactive materials and systems. Full understanding of the multiple electrochemical mechanisms can be achieved only by utilizing advanced characterization tools over multiple length scales.

Identification of EBP50 as a Specific Biomarker for Carcinogens Via the Analysis of Mouse Lymphoma Cellular Proteome

PubMed Central

Lee, Yoen Jung; Choi, In-Kwon; Sheen, Yhun Yhong; Park, Sue Nie; Kwon, Ho Jeong

2012-01-01

To identify specific biomarkers generated upon exposure of L5178Y mouse lymphoma cells to carcinogens, 2-DE and MALDI-TOF MS analysis were conducted using the cellular proteome of L5178Y cells that had been treated with the known carcinogens, 1,2-dibromoethane and O-nitrotoluene and the noncarcinogens, emodin and D-mannitol. Eight protein spots that showed a greater than 1.5-fold increase or decrease in intensity following carcinogen treatment compared with treatment with noncarcinogens were selected. Of the identified proteins, we focused on the candidate biomarker ERM-binding phosphoprotein 50 (EBP50), the expression of which was specifically increased in response to treatment with the carcinogens. The expression level of EBP50 was determined by western analysis using polyclonal rabbit anti-EBP50 antibody. Further, the expression level of EBP50 was increased in cells treated with seven additional carcinogens, verifying that EBP50 could serve as a specific biomarker for carcinogens. PMID:22434383

Identification of EBP50 as a specific biomarker for carcinogens via the analysis of mouse lymphoma cellular proteome.

PubMed

Lee, Yoen Jung; Choi, In-Kwon; Sheen, Yhun Yhong; Park, Sue Nie; Kwon, Ho Jeong

2012-03-01

To identify specific biomarkers generated upon exposure of L5178Y mouse lymphoma cells to carcinogens, 2-DE and MALDI-TOF MS analysis were conducted using the cellular proteome of L5178Y cells that had been treated with the known carcinogens, 1,2-dibromoethane and O-nitrotoluene and the noncarcinogens, emodin and D-mannitol. Eight protein spots that showed a greater than 1.5-fold increase or decrease in intensity following carcinogen treatment compared with treatment with noncarcinogens were selected. Of the identified proteins, we focused on the candidate biomarker ERM-binding phosphoprotein 50 (EBP50), the expression of which was specifically increased in response to treatment with the carcinogens. The expression level of EBP50 was determined by western analysis using polyclonal rabbit anti-EBP50 antibody. Further, the expression level of EBP50 was increased in cells treated with seven additional carcinogens, verifying that EBP50 could serve as a specific biomarker for carcinogens.

Using marketing research methods to evaluate a stage-specific intervention.

PubMed

Poscente, Neila; Rothstein, Marsha; Irvine, M Jane

2002-01-01

To show how marketing methods can be used to distribute and evaluate a health promotion intervention. Mass media promotion was used to communicate a physical activity resource. Brief telephone interviews were used to screen callers and recruit participants into a controlled trial. Follow-up was conducted 3 months later. Information was gained about the attitudes and motivation of callers. The majority of participants (study and control) made significant changes in their activity levels. The study demonstrated that even when mass media channels are used, market segmentation can be achieved and program evaluation conducted.

On the validity and generality of transfer effects in cognitive training research.

PubMed

Noack, Hannes; Lövdén, Martin; Schmiedek, Florian

2014-11-01

Evaluation of training effectiveness is a long-standing problem of cognitive intervention research. The interpretation of transfer effects needs to meet two criteria, generality and specificity. We introduce each of the two, and suggest ways of implementing them. First, the scope of the construct of interest (e.g., working memory) defines the expected generality of transfer effects. Given that the constructs of interest are typically defined at the latent level, data analysis should also be conducted at the latent level. Second, transfer should be restricted to measures that are theoretically related to the trained construct. Hence, the construct of interest also determines the specificity of expected training effects; to test for specificity, study designs should aim at convergent and discriminant validity. We evaluate the recent cognitive training literature in relation to both criteria. We conclude that most studies do not use latent factors for transfer assessment, and do not test for convergent and discriminant validity.

Field evaluation of a malaria rapid diagnostic test (ICT Pf).

PubMed

Moonasar, Devanand; Goga, Ameena E; Kruger, Philip S; La Cock, Christine; Maharaj, Rajendra; Frean, John; Chandramohan, Daniel

2009-11-01

Malaria rapid diagnostic tests (MRDTs) are quick and easy to perform and useful for diagnosing malaria in primary health care settings. In South Africa most malaria infections are due to Plasmodium falciparurrm, and HRPII-based MRDTs have been used since 2001. Previous studies in Africa showed variability in sensitivity and specificity of HRPII-based MRDTs; hence, we conducted a field evaluation in Limpopo province to determine the accuracy of the MRDT currently used in public sector clinics and hospitals. A cross-sectional observational study was conducted to determine the sensitivity and specificity of an ICT Pf MRDT. We tested 405 patients with fever with ICT Pf MRDT and compared the results with blood film microscopy (the gold standard). RESULTS. The overall sensitivity of the ICT Pf MRDT was 99.48% (95% confidence interval (CI) 96.17-100%), while specificity was 96.26% (95% CI 94.7-100%). The positive predictive value of the test was 98.48 (99% CI 98.41-100%), and the negative predictive value was 99.52% (95% CI 96.47-100%). The ICT Pf MRDT is an appropriate test to use in the field in South Africa where laboratory facilities are not available. It has a high degree of sensitivity and acceptable level of specificity in accordance with the World Health Organization criteria. However, sensitivity of MRDT at low levels of parasitaemia (<100 parasites/microl of blood) in field conditions must still be established.

Performance of a low-power subsonic-arc-attachment arcjet thruster

NASA Technical Reports Server (NTRS)

Sankovic, John M.; Berns, Darren H.

1993-01-01

A subsonic-arc-attachment thruster design was scaled from a 30 kW 1960's vintage thruster to operate at nominally 3 kW. Performance measurements were obtained over a 1-4 kW power range using hydrogen as the propellant. Several modes of operation were identified and were characterized by varying degrees of voltage instability. A stability map was developed showing that the voltage oscillations were brought upon by elevated current or propellant levels. At a given specific energy level the specific impulse increased asymptotically with increased flow rates. Comparisons of performance were made between radial and tangential propellant injection. When the vortex flow was eliminated using radial injection, the operating voltages were lower at a given current, and the specific impulse and efficiency decreased. Tests were also conducted to determine the effects of background pressure on operation, and performance data were obtained at pressures of 0.047 Pa and 18 Pa. For a given specific energy level, the performance increased with a decrease in facility background pressure. Lowering the background pressure also caused a dramatic change in the voltage-current characteristic and the voltage stability, a phenomenon not previously reported with conventional supersonic-arc-attachment thrusters.

Analysis and simulation of water-level, specific conductance, and total phosphorus dynamics of the Loxahatchee National Wildlife Refuge, Florida, 1995-2006

USGS Publications Warehouse

Conrads, Paul; Roehl, Edwin A.

2010-01-01

Two scenarios were simulated with the LOXANN DSS. One scenario increased the historical flows at four control structures by 40 percent. The second scenario used a user-defined hydrograph to set the outflow from the Refuge to the weekly average inflow to the Refuge delayed by 2 days. Both scenarios decreased the potential of canal water intruding into the marsh by decreasing the slope of the water level between the canals and the marsh.

A parallel process growth mixture model of conduct problems and substance use with risky sexual behavior.

PubMed

Wu, Johnny; Witkiewitz, Katie; McMahon, Robert J; Dodge, Kenneth A

2010-10-01

Conduct problems, substance use, and risky sexual behavior have been shown to coexist among adolescents, which may lead to significant health problems. The current study was designed to examine relations among these problem behaviors in a community sample of children at high risk for conduct disorder. A latent growth model of childhood conduct problems showed a decreasing trend from grades K to 5. During adolescence, four concurrent conduct problem and substance use trajectory classes were identified (high conduct problems and high substance use, increasing conduct problems and increasing substance use, minimal conduct problems and increasing substance use, and minimal conduct problems and minimal substance use) using a parallel process growth mixture model. Across all substances (tobacco, binge drinking, and marijuana use), higher levels of childhood conduct problems during kindergarten predicted a greater probability of classification into more problematic adolescent trajectory classes relative to less problematic classes. For tobacco and binge drinking models, increases in childhood conduct problems over time also predicted a greater probability of classification into more problematic classes. For all models, individuals classified into more problematic classes showed higher proportions of early sexual intercourse, infrequent condom use, receiving money for sexual services, and ever contracting an STD. Specifically, tobacco use and binge drinking during early adolescence predicted higher levels of sexual risk taking into late adolescence. Results highlight the importance of studying the conjoint relations among conduct problems, substance use, and risky sexual behavior in a unified model. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Physical education resources, class management, and student physical activity levels: a structure-process-outcome approach to evaluating physical education effectiveness.

PubMed

Bevans, Katherine B; Fitzpatrick, Leslie-Anne; Sanchez, Betty M; Riley, Anne W; Forrest, Christopher

2010-12-01

This study was conducted to empirically evaluate specific human, curricular, and material resources that maximize student opportunities for physical activity during physical education (PE) class time. A structure-process-outcome model was proposed to identify the resources that influence the frequency of PE and intensity of physical activity during PE. The proportion of class time devoted to management was evaluated as a potential mediator of the relations between resource availability and student activity levels. Data for this cross-sectional study were collected from interviews conducted with 46 physical educators and the systematic observation of 184 PE sessions in 34 schools. Regression analyses were conducted to test for the main effects of resource availability and the mediating role of class management. Students who attended schools with a low student-to-physical educator ratio had more PE time and engaged in higher levels of physical activity during class time. Access to adequate PE equipment and facilities was positively associated with student activity levels. The availability of a greater number of physical educators per student was found to impact student activity levels by reducing the amount of session time devoted to class management. The identification of structure and process predictors of student activity levels in PE will support the allocation of resources and encourage instructional practices that best support increased student activity levels in the most cost-effective way possible. Implications for PE policies and programs are discussed. © 2010, American School Health Association.

Situational and respondent-level motives for drinking and alcohol-related aggression: a multilevel analysis of drinking events in a sample of Canadian university students.

PubMed

Mihic, Ljiljana; Wells, Samantha; Graham, Kathryn; Tremblay, Paul F; Demers, Andrée

2009-03-01

Situational drinking motives (i.e., motives specific to the drinking situation) as well as respondent-level drinking motives (i.e., usual drinking motives across drinking situations) were examined in terms of their relations with aggression experienced by university students. Secondary, multi-level analyses were conducted on the Canadian Campus Survey (CCS), a national survey of 40 Canadian universities conducted between March 1 and April 30, 2004 (N=6,282). For their three most recent drinking events, students reported their motive for drinking (i.e., situational motive) and whether they had an argument/fight. Respondent-level drinking motives were computed by averaging motives across drinking events. Drinking to cope at the situational-level increased the likelihood of aggression. Respondent-level enhancement motives also increased the risk of aggression. Aesthetic motives were important at both situational and respondent levels decreasing the risk for alcohol-related aggression. Gender did not moderate these relations. These results suggest that prevention programming might benefit from a focus on altering drinking motives, or their underlying causes, in order to reduce alcohol-related aggression among young adults.

Promoting Influenza Vaccination to Restaurant Employees.

PubMed

Graves, Meredith C; Harris, Jeffrey R; Hannon, Peggy A; Hammerback, Kristen; Parrish, Amanda T; Ahmed, Faruque; Zhou, Chuan; Allen, Claire L

2016-09-01

To evaluate an evidence-based workplace approach to increasing adult influenza vaccination levels applied in the restaurant setting We implemented an intervention and conducted a pre/post analysis to determine effect on vaccination. Eleven Seattle-area restaurants. Restaurants with 25+ employees speaking English or Spanish and over 18 years. Restaurants received influenza vaccination promotion materials, assistance arranging on-site vaccination events, and free influenza vaccinations for employees. Pre/post employee surveys of vaccination status with direct observation and employer interviews to evaluate implementation. We conducted descriptive analysis of employee survey data and performed qualitative analysis of implementation data. To assess intervention effect, we used a mixed-effects logistic regression model with a restaurant-specific random effect. Vaccination levels increased from 26% to 46% (adjusted odds ratio 2.33, 95% confidence interval 1.69, 3.22), with 428 employees surveyed preintervention, 305 surveyed postintervention, and response rates of 73% and 55%, respectively. The intervention was effective across subgroups, but there were restaurant-level differences. An access-based workplace intervention can increase influenza vaccination levels in restaurant employees, but restaurant-level factors may influence success. © 2016 by American Journal of Health Promotion, Inc.

Analysis of pumping tests: Significance of well diameter, partial penetration, and noise

USGS Publications Warehouse

Heidari, M.; Ghiassi, K.; Mehnert, E.

1999-01-01

The nonlinear least squares (NLS) method was applied to pumping and recovery aquifer test data in confined and unconfined aquifers with finite diameter and partially penetrating pumping wells, and with partially penetrating piezometers or observation wells. It was demonstrated that noiseless and moderately noisy drawdown data from observation points located less than two saturated thicknesses of the aquifer from the pumping well produced an exact or acceptable set of parameters when the diameter of the pumping well was included in the analysis. The accuracy of the estimated parameters, particularly that of specific storage, decreased with increases in the noise level in the observed drawdown data. With consideration of the well radii, the noiseless drawdown data from the pumping well in an unconfined aquifer produced good estimates of horizontal and vertical hydraulic conductivities and specific yield, but the estimated specific storage was unacceptable. When noisy data from the pumping well were used, an acceptable set of parameters was not obtained. Further experiments with noisy drawdown data in an unconfined aquifer revealed that when the well diameter was included in the analysis, hydraulic conductivity, specific yield and vertical hydraulic conductivity may be estimated rather effectively from piezometers located over a range of distances from the pumping well. Estimation of specific storage became less reliable for piezemeters located at distances greater than the initial saturated thickness of the aquifer. Application of the NLS to field pumping and recovery data from a confined aquifer showed that the estimated parameters from the two tests were in good agreement only when the well diameter was included in the analysis. Without consideration of well radii, the estimated values of hydraulic conductivity from the pumping and recovery tests were off by a factor of four.The nonlinear least squares method was applied to pumping and recovery aquifer test data in confined and unconfined aquifers with finite diameter and partially penetrating piezometers and observation wells. Noiseless and moderately noisy drawdown data from observation points located less than two saturated thicknesses of the aquifer from the pumping well produced a set of parameters that agrees very well with piezometer test data when the diameter of the pumping well was included in the analysis. The accuracy of the estimated parameters decreased with increasing noise level.

N-terminal pro-B-type Natriuretic Peptides' Prognostic Utility Is Overestimated in Meta-analyses Using Study-specific Optimal Diagnostic Thresholds.

PubMed

Potgieter, Danielle; Simmers, Dale; Ryan, Lisa; Biccard, Bruce M; Lurati-Buse, Giovanna A; Cardinale, Daniela M; Chong, Carol P W; Cnotliwy, Miloslaw; Farzi, Sylvia I; Jankovic, Radmilo J; Lim, Wen Kwang; Mahla, Elisabeth; Manikandan, Ramaswamy; Oscarsson, Anna; Phy, Michael P; Rajagopalan, Sriram; Van Gaal, William J; Waliszek, Marek; Rodseth, Reitze N

2015-08-01

N-terminal fragment B-type natriuretic peptide (NT-proBNP) prognostic utility is commonly determined post hoc by identifying a single optimal discrimination threshold tailored to the individual study population. The authors aimed to determine how using these study-specific post hoc thresholds impacts meta-analysis results. The authors conducted a systematic review of studies reporting the ability of preoperative NT-proBNP measurements to predict the composite outcome of all-cause mortality and nonfatal myocardial infarction at 30 days after noncardiac surgery. Individual patient-level data NT-proBNP thresholds were determined using two different methodologies. First, a single combined NT-proBNP threshold was determined for the entire cohort of patients, and a meta-analysis conducted using this single threshold. Second, study-specific thresholds were determined for each individual study, with meta-analysis being conducted using these study-specific thresholds. The authors obtained individual patient data from 14 studies (n = 2,196). Using a single NT-proBNP cohort threshold, the odds ratio (OR) associated with an increased NT-proBNP measurement was 3.43 (95% CI, 2.08 to 5.64). Using individual study-specific thresholds, the OR associated with an increased NT-proBNP measurement was 6.45 (95% CI, 3.98 to 10.46). In smaller studies (<100 patients) a single cohort threshold was associated with an OR of 5.4 (95% CI, 2.27 to 12.84) as compared with an OR of 14.38 (95% CI, 6.08 to 34.01) for study-specific thresholds. Post hoc identification of study-specific prognostic biomarker thresholds artificially maximizes biomarker predictive power, resulting in an amplification or overestimation during meta-analysis of these results. This effect is accentuated in small studies.

An evaluation of water-quality data obtained at four streamflow daily-record stations in Idaho

USGS Publications Warehouse

Dyer, Kenneth L.

1973-01-01

Chemical data for four stream-gaging stations in Idaho, each having 6 to 22 years of available records, were analyzed to determine functional relations between concentrations of the major inorganic constituents, specific conductance, and stream discharge. Three of the four stations had sufficient available record for assessing changes in constituent relations with time. The records for each long-term station were subdivided into segments of approximately 5 years each. Plots and regression equations were derived for each record segment to show the relations of each major constituent value to levels of specific conductance and stream discharge. At only one stations, Boise River at Notus, was there was an apparent significant change in chemical characteristics with time. Between 1940 and 1951, the percentages of chloride and sulfate in solution at this station declined appreciably and were largely replaced by bicarbonate. In general, there were highly significant correlations between the major inorganic ions and specific conductance, although those observed at Bear River at Border were distinctly poorer than those observed for the other stations. Corresponding correlations between the major ions and discharge were almost always less significant than those observed between the same ions and specific conductance. The common ion-discharge relations observed on the Snake River near Heise were more highly correlated before 1957 than thereafter--probably because of changes induced by the construction of Palisades Dam. A similar decline in correlation of common ion-discharge relations was observed at the Snake River at King Hill station after 1957, and this also might be attributable to changes in water regulation at various upstream impoundments.

Crisis resolution: consumer, family and referrer perspectives on care.

PubMed

Carter, Frances A; Taylor, M Joan; Weston, Madeline J; Quigley, Teresa A; Beveridge, John H; Green, Robert Aj; Duffy, Steve

2018-06-08

To systematically assess the service satisfaction of consumers, their families and referrers with crisis resolution (CR). Consecutive consumers discharged after receiving CR over a five-week period were potentially eligible for participation, together with their family and referrer (broadly defined). Structured telephone interviews were conducted and involved forced-choice questions assessing global satisfaction and satisfaction with specific aspects of care, plus two open-ended questions. Participants were 75 consumers, 22 family and 16 referrers. High levels of satisfaction were seen for all participants for both global (86-96%) and most specific aspects of care (>75%). If consumers were dissatisfied with their overall care, they were significantly more likely to be aged 25-34 years of age. High levels of agreement among raters were found for global satisfaction (>85%) and most specific aspects of care (>70%), which provides some level of reassurance for staff. Open-ended questions showed that having effective treatment of sufficient duration and staff manner were most important to participants. High levels of satisfaction and agreement were found among consumers, family and referrers with CR. Open-ended questions identified which issues matter the most to key stakeholders, which may have implications for service evaluation tools.

Aggregation of Adenovirus 2 in Source Water and Impacts on Disinfection by Chlorine

PubMed Central

Cromeans, Theresa L.; Metcalfe, Maureen G.; Humphrey, Charles D.; Hill, Vincent R.

2016-01-01

It is generally accepted that viral particles in source water are likely to be found as aggregates attached to other particles. For this reason, it is important to investigate the disinfection efficacy of chlorine on aggregated viruses. A method to produce adenovirus particle aggregation was developed for this study. Negative stain electron microscopy was used to measure aggregation before and after addition of virus particles to surface water at different pH and specific conductance levels. The impact of aggregation on the efficacy of chlorine disinfection was also examined. Disinfection experiments with human adenovirus 2 (HAdV2) in source water were conducted using 0.2 mg/L free chlorine at 5 °C. Aggregation of HAdV2 in source water (≥3 aggregated particles) remained higher at higher specific conductance and pH levels. However, aggregation was highly variable, with the percentage of particles present in aggregates ranging from 43 to 71 %. Upon addition into source water, the aggregation percentage dropped dramatically. On average, chlorination CT values (chlorine concentration in mg/L × time in min) for 3-log10 inactivation of aggregated HAdV2 were up to three times higher than those for dispersed HAdV2, indicating that aggregation reduced the disinfection rate. This information can be used by water utilities and regulators to guide decision making regarding disinfection of viruses in water. PMID:26910058

Aggregation of Adenovirus 2 in Source Water and Impacts on Disinfection by Chlorine.

PubMed

Kahler, Amy M; Cromeans, Theresa L; Metcalfe, Maureen G; Humphrey, Charles D; Hill, Vincent R

2016-06-01

It is generally accepted that viral particles in source water are likely to be found as aggregates attached to other particles. For this reason, it is important to investigate the disinfection efficacy of chlorine on aggregated viruses. A method to produce adenovirus particle aggregation was developed for this study. Negative stain electron microscopy was used to measure aggregation before and after addition of virus particles to surface water at different pH and specific conductance levels. The impact of aggregation on the efficacy of chlorine disinfection was also examined. Disinfection experiments with human adenovirus 2 (HAdV2) in source water were conducted using 0.2 mg/L free chlorine at 5 °C. Aggregation of HAdV2 in source water (≥3 aggregated particles) remained higher at higher specific conductance and pH levels. However, aggregation was highly variable, with the percentage of particles present in aggregates ranging from 43 to 71 %. Upon addition into source water, the aggregation percentage dropped dramatically. On average, chlorination CT values (chlorine concentration in mg/L × time in min) for 3-log10 inactivation of aggregated HAdV2 were up to three times higher than those for dispersed HAdV2, indicating that aggregation reduced the disinfection rate. This information can be used by water utilities and regulators to guide decision making regarding disinfection of viruses in water.

Low-temperature thermal properties of a hyperaged geological glass.

PubMed

Pérez-Castañeda, Tomás; Jiménez Riobóo, Rafael J; Ramos, Miguel A

2013-07-24

We have measured the specific heat of amber from the Dominican Republic, an ancient geological glass about 20 million years old, in the low-temperature range 0.6 K ≤ T ≤ 26 K, in order to assess the effects of its natural stabilization (hyperageing) process on the low-temperature glassy properties, i.e. boson peak and two-level systems. We have also conducted modulated differential scanning calorimetry experiments to characterize the thermodynamic state of our samples. We found that calorimetric curves exhibit a huge ageing signal ΔH ≈ 5 J g(-1) in the first upscan at the glass transition Tg = 389 K, that completely disappears after heating up (rejuvenating) the sample to T = 395 K for 3 h. To independently evaluate the phonon contribution to the specific heat, Brillouin spectroscopy was performed in the temperature range 80 K ≤ T ≤ 300 K. An expected increase in the Debye level was observed after rejuvenating the Dominican amber. However, no significant change was observed in the low-temperature specific heat of glassy amber after erasing its thermal history: both its boson peak (i.e., the maximum in the Cp/T(3) representation) and the density of tunnelling two-level systems (i.e., the Cp ∼ T contribution at the lowest temperatures) remained essentially the same. Also, a consistent analysis using the soft-potential model of our Cp data and earlier thermal-conductivity data found in the literature further supports our main conclusion, namely, that these glassy 'anomalous' properties at low temperatures remain essentially invariant after strong relaxational processes such as hyperageing.

Overcoming Impediments to Learning the Four Language Skills Using Note Books

ERIC Educational Resources Information Center

Christopher, Anne A.

2016-01-01

The level of awareness of the importance of mastering ESL among the local community is poor, particularly in rural areas. A study was conducted to gather information from English as a Second Language (ESL) learners pertaining to the impediments of English Language learning (ELL) by specifically focusing on the four language skills namely…

Teaching Students with Autism Spectrum Disorder in Mainstream Post-Primary Schools in the Republic of Ireland

ERIC Educational Resources Information Center

McGillicuddy, Sarah; O'Donnell, Grainne M.

2014-01-01

This qualitative study explored teachers' perceptions of the inclusive education of students with autism spectrum disorder (ASD) at the post-primary level, specifically those with Asperger syndrome. Semi-structured interviews were conducted with eight mainstream teachers in the Republic of Ireland. One of the main findings of the study was that…

43 CFR 3809.415 - How do I prevent unnecessary or undue degradation while conducting operations on public lands?

Code of Federal Regulations, 2011 CFR

2011-10-01

... protection and protection of cultural resources; (b) Assuring that your operations are “reasonably incident... (c) Attaining the stated level of protection or reclamation required by specific laws in areas such as the California Desert Conservation Area, Wild and Scenic Rivers, BLM-administered portions of the...

The Role of Substance Use Initiation in Adolescent Development of Subsequent Substance-Related Problems

ERIC Educational Resources Information Center

Magid, Viktoriya; Moreland, Angela D.

2014-01-01

A systematic review was conducted on the role of substance use initiation in subsequent use and substance-related problems among adolescents. Specifically, we examine previous studies to identify whether age of onset predicts subsequent levels of misuse; we also posit reasons for this association that have been suggested within the literature. In…

The Achievement Gap in Reading: Complex Causes, Persistent Issues, Possible Solutions

ERIC Educational Resources Information Center

Horowitz, Rosalind, Ed.; Samuels, S. Jay, Ed.

2017-01-01

In this volume prominent scholars, experts in their respective fields and highly skilled in the research they conduct, address educational and reading research from varied perspectives and address what it will take to close the achievement gap--with specific attention to reading. The achievement gap is redefined as a level at which all groups can…

A Longitudinal Study of Middle and Secondary Level Science Textbook Vocabulary Loads

ERIC Educational Resources Information Center

Groves, Fred H.

2016-01-01

Middle and secondary science textbooks have long been a primary support for instruction, often leading to heavy emphasis on domain-specific vocabulary. A longitudinal study was conducted to compare vocabulary loads of science textbooks published since 2010 to results of two previous studies going back to 1983. In each study, textbooks chosen…

Characterization of indoor home vacuum dust allergens and serum based allergen specific IgE levels in asthmatic and non-asthmatic children

EPA Science Inventory

The Mechanistic Indicators of Childhood Asthma (MICA) study was conducted in the Detroit, Michigan area during fall to early winter 2006-2007. Children from 9-13 years of age were recruited into a cross-sectional study to examine biological markers of exposure, effects, and susce...

76 FR 73652 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-29

... national and regional levels; and b. Implementation of two surveys to collect the information needed to develop HIV-specific input parameters for the forecasting model, as well as to help address other research questions of the study. HRSA is requesting OMB approval to conduct a HIV clinician survey and a HIV practice...

77 FR 1495 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-10

... regional levels; and b. Implementation of two surveys to collect the information needed to develop HIV-specific input parameters for the forecasting model, as well as to help address other research questions of the study. HRSA is requesting OMB approval to conduct a HIV clinician survey and a HIV practice survey...

Be My Guest: A Survey of Mass Communication Students' Perception of Guest Speakers

ERIC Educational Resources Information Center

Merle, Patrick F.; Craig, Clay

2017-01-01

The use of guest speakers as a pedagogical technique across disciplines at the college level is hardly novel. However, empirical assessment of journalism and mass communication students' perceptions of this practice has not previously been conducted. To fill this gap, this article presents results from an online survey specifically administered to…

Intersecting Identities of Female College Student Intramural Sports Officials: A Grounded Theory

ERIC Educational Resources Information Center

Flint, April Susanne

2012-01-01

Intramural activities are conducted on virtually every college campus throughout the United States, but there is a debate as to the role of intramurals in the overall development of the student (Rothwell & Theodore, 2006). Specifically for females, not every sport is offered for participation at youth or higher levels, but intramural sports is…

Print-Focused Read-Alouds in Preschool Classrooms: Intervention Effectiveness and Moderators of Child Outcomes

ERIC Educational Resources Information Center

Justice, Laura M.; McGinty, Anita S.; Piasta, Shayne B.; Kaderavek, Joan N.; Fan, Xitao

2010-01-01

Purpose: This study was conducted to determine the effectiveness of teachers' use of a print-referencing style during whole-class read-alouds with respect to accelerating 4- and 5-year-old children's print-knowledge development. It also examined 8 specific child- and setting-level moderators to determine whether these influenced the relation…

Reducing stigma in healthcare and law enforcement: a novel approach to service provision for street level sex workers.

PubMed

Bodkin, Kate; Delahunty-Pike, Alannah; O'Shea, Tim

2015-04-09

Providing services for street level sex workers requires a multidisciplinary approach, addressing both health and safety concerns typical of their age and gender and those that arise specific to their line of work. Despite being a diverse population, studies have identified some specific health needs for sex workers including addictions treatment, mental health. Additionally, studies have shown a higher risk of physical and sexual assault for this population. The Persons at Risk program (PAR) in London, Ontario, Canada was started in 2005 to address the specific needs of street level sex workers by using a harm-reduction model for policing and healthcare provision. This qualitative study evaluated this model of care in terms of improving access to healthcare and essential police services for street level sex workers. A total of 14 semi-structured interviews were conducted with current and former female street level sex workers enrolled in the PAR program. In addition, 3 semi-structured interviews were conducted with health and law enforcement professionals. The research team then analyzed and coded the transcripts using qualitative description to identify key themes in the data. Results indicated that participants represent a vulnerable population with increased safety concerns and healthcare needs relating to addictions, mental health and infectious disease. Despite this, participants reported avoiding healthcare workers and police officers in the past because of fear of stigma or repercussions. All participants identified the harm reduction approach of the PAR program as being essential to their continued engagement with the program. Other important aspects included flexible hours, the location of the clinic, streamlined access to mental health and addictions treatment and the female gender of the police and healthcare worker. The PAR program provides sex workers access to much needed primary healthcare that is flexible and without judgment. In addition, they are provided with a direct avenue to access law enforcement. We feel a similar model of care could be applicable to many cities across Canada.

The VERB campaign's strategy for reaching African-American, Hispanic, Asian, and American Indian children and parents.

PubMed

Huhman, Marian; Berkowitz, Judy M; Wong, Faye L; Prosper, Erika; Gray, Michael; Prince, David; Yuen, Jeannie

2008-06-01

The VERB campaign promoted physical activity to U.S. children aged 9-13 years (tweens) by surrounding them with appealing messages that were associated with the VERB brand and tag line It's what you do! To maximize the impact of the campaign, VERB had a two-level strategy for its marketing. One level was designed to reach a general audience of tweens (i.e., most tweens who use mainstream media). The second level was designed specifically to reach four racial or ethnic audiences: African Americans, Hispanics, Asian Americans, and American Indians as an augmentation to the first level. This article focuses on VERB's market segmentation strategy and reports how messages for the general audience were adapted to reach specific racial or ethnic segments of the U.S. population. Findings are reported from qualitative studies conducted with tweens and the parents of tweens from these ethnic groups, and the marketing strategies used to reach each ethnic group and the results of evaluations of those strategies are also described.

Sea-Level Flight Demonstration and Altitude Characterization of a LO2/LCH4 Based Accent Propulsion Lander

NASA Technical Reports Server (NTRS)

Collins, Jacob; Hurlbert, Eric; Romig, Kris; Melcher, John; Hobson, Aaron; Eaton, Phil

2009-01-01

A 1,500 lbf thrust-class liquid oxygen (LO2)/Liquid Methane (LCH4) rocket engine was developed and tested at both sea-level and simulated altitude conditions. The engine was fabricated by Armadillo Aerospace (AA) in collaboration with NASA Johnson Space Center. Sea level testing was conducted at Armadillo Aerospace facilities at Caddo Mills, TX. Sea-level tests were conducted using both a static horizontal test bed and a vertical take-off and landing (VTOL) test bed capable of lift-off and hover-flight in low atmosphere conditions. The vertical test bed configuration is capable of throttling the engine valves to enable liftoff and hover-flight. Simulated altitude vacuum testing was conducted at NASA Johnson Space Center White Sands Test Facility (WSTF), which is capable of providing altitude simulation greater than 120,000 ft equivalent. The engine tests demonstrated ignition using two different methods, a gas-torch and a pyrotechnic igniter. Both gas torch and pyrotechnic ignition were demonstrated at both sea-level and vacuum conditions. The rocket engine was designed to be configured with three different nozzle configurations, including a dual-bell nozzle geometry. Dual-bell nozzle tests were conducted at WSTF and engine performance data was achieved at both ambient pressure and simulated altitude conditions. Dual-bell nozzle performance data was achieved over a range of altitude conditions from 90,000 ft to 50,000 ft altitude. Thrust and propellant mass flow rates were measured in the tests for specific impulse (Isp) and C* calculations.

The 2011 nuclear medicine technology job analysis project of the American Registry of Radiologic Technologists.

PubMed

Anderson, Dan; Hubble, William; Press, Bret A; Hall, Scott K; Michels, Ann D; Koenen, Roxanne; Vespie, Alan W

2010-12-01

The American Registry of Radiologic Technologists (ARRT) conducts periodic job analysis projects to update the content and eligibility requirements for all certification examinations. In 2009, the ARRT conducted a comprehensive job analysis project to update the content specifications and clinical competency requirements for the nuclear medicine technology examination. ARRT staff and a committee of volunteer nuclear medicine technologists designed a job analysis survey that was sent to a random sample of 1,000 entry-level staff nuclear medicine technologists. Through analysis of the survey data and judgments of the committee, the project resulted in changes to the nuclear medicine technology examination task list, content specifications, and clinical competency requirements. The primary changes inspired by the project were the introduction of CT content to the examination and the expansion of the content covering cardiac procedures.

Science Misconceptions and Funds of Knowledge: Impact on STEM Choices

NASA Astrophysics Data System (ADS)

Millham, R. A.

2015-12-01

Alternate conceptions (misconceptions) in science can hinder understandings and impact student growth and comfort level in the science classroom. Resarch has, and still does, demonstrate that science misconceptions are still prevelant in many conceptual frameworks. Although breaking down misconceptions to rebuild scientifically sound conceptual frameworks are practices used in many science classrooms, misconceptions still persist. After identifying specific misconceptions, we asked our participating teachers to conduct specific instructional interventions in an effort to mitigate misconceptions and bring about scientific understandings with excellent results overall. However, important factors also need condsideration: funds of knowledge and the abilty to determine the differnce between understandings and beliefs held by an individual. This abstract deals with what has been determined in the research conducted by the author, and the next steps to better understandings about how to mitigate alternate conceptions.

Water-quality and ground-water-level trends, 1990-99, and data collected from 1995 through 1999, East Mountain area, Bernalillo County, central New Mexico

USGS Publications Warehouse

Rankin, D.R.

2000-01-01

Bernalillo County officials recognize the importance of monitoring water quality and ground-water levels in rapidly developing areas. For this reason, water-quality and ground-water- level data were collected from 87 wells, 3 springs, and the Ojo Grande Acequia in the east mountain area of Bernalillo County between January 1990 and June 1999. The water samples were analyzed for selected nutrient species; total organic carbon; major dissolved constituents; methylene blue active substances; and dissolved arsenic. Analytical results were used to compute hardness, sodium adsorption ratio, and dissolved solids. Specific conductance, pH, air and water temperature, alkalinity, and dissolved oxygen were measured in the field at the time of sample collection. Ground-water levels were measured at the time of sample collection. From January 1990 through June 1993, water-quality and ground- water-level data were collected monthly from an initial set of 20 wells; these data were published in a 1995 report. During 1995, water samples and ground-water-level data were collected and analyzed from the initial set of 20 wells and from an additional 31 wells, 2 springs, and the Ojo Grande Acequia; these data were published in a 1996 report. Additional water-quality and ground-water-level data have been collected from sites in the east mountain area: 34 wells and the acequia during 1997, 14 wells and 1 spring during 1998, and 6 wells during 1999. Water-quality and ground- water-level data collected in the east mountain area during 1995 through 1999 are presented in tables. In addition, temporal trends for ground-water levels, concentrations of total and dissolved nitrite plus nitrate, concentrations of dissolved chloride, and specific conductance are presented for 20 selected wells in water-quality and water- level hydrographs.

Vapour pressure deficit during growth has little impact on genotypic differences of transpiration efficiency at leaf and whole-plant level: an example from Populus nigra L.

PubMed

Rasheed, Fahad; Dreyer, Erwin; Richard, Béatrice; Brignolas, Franck; Brendel, Oliver; Le Thiec, Didier

2015-04-01

Poplar genotypes differ in transpiration efficiency (TE) at leaf and whole-plant level under similar conditions. We tested whether atmospheric vapour pressure deficit (VPD) affected TE to the same extent across genotypes. Six Populus nigra genotypes were grown under two VPD. We recorded (1) (13)C content in soluble sugars; (2) (18)O enrichment in leaf water; (3) leaf-level gas exchange; and (4) whole-plant biomass accumulation and water use. Whole-plant and intrinsic leaf TE and (13)C content in soluble sugars differed significantly among genotypes. Stomatal conductance contributed more to these differences than net CO2 assimilation rate. VPD increased water use and reduced whole-plant TE. It increased intrinsic leaf-level TE due to a decline in stomatal conductance. It also promoted higher (18)O enrichment in leaf water. VPD had no genotype-specific effect. We detected a deviation in the relationship between (13)C in leaf sugars and (13)C predicted from gas exchange and the standard discrimination model. This may be partly due to genotypic differences in mesophyll conductance, and to its lack of sensitivity to VPD. Leaf-level (13)C discrimination was a powerful predictor of the genetic variability of whole-plant TE irrespective of VPD during growth. © 2014 John Wiley & Sons Ltd.

NASA's 2004 Hall Thruster Program

NASA Technical Reports Server (NTRS)

Jacobson, David T.; Manzella, David H.; Hofer, Richard R.; Peterson, Peter Y.

2004-01-01

An overview of NASA's Hall thruster research and development tasks conducted during fiscal year 2004 is presented. These tasks focus on: raising the technology readiness level of high power Hall thrusters, developing a moderate-power/ moderate specific impulse Hall thruster, demonstrating high-power/high specific impulse Hall thruster operation, and addressing the fundamental technical challenges of emerging Hall thruster concepts. Programmatic background information, technical accomplishments and out year plans for each program element performed under the sponsorship of the In-Space Transportation Program, Project Prometheus, and the Energetics Project are provided.

An expanded ostracod-based conductivity transfer function for climate reconstruction in the Levant

NASA Astrophysics Data System (ADS)

Mischke, Steffen; Almogi-Labin, Ahuva; Al-Saqarat, Bety; Rosenfeld, Arik; Elyashiv, Hadar; Boomer, Ian; Stein, Mordechai; Lev, Lilach; Ito, Emi

2014-06-01

We present the first modern calibration dataset linking ostracod assemblage composition to water chemistry, and other site-specific variables, in the hydrologically and geopolitically sensitive southern Levant region. A total of 42 ostracod taxa were recorded from the 178 sampled sites in Israel and Jordan. Ilyocypris spp., Heterocypris salina and Cypridopsis vidua are the most abundant taxa. Species strictly confined to freshwater conditions are Prionocypris zenkeri, Gomphocythere ortali and Prionocypris olivaceus. In contrast, H. salina, Bradleytriebella lineata and Cyprideis torosa show high frequencies in brackish waters (waters with higher conductivity). Humphcypris subterranea, G. ortali, P. olivaceus and Cypridopsis elongata apparently prefer flowing waters. Specific conductivity optima and tolerance ranges were calculated for the recorded ostracod species and may be used for the palaeoenvironmental assessment of fossil ostracod assemblages. In addition, a transfer-function for quantitative specific conductivity estimation based on 141 samples was established with weighted averaging partial least squares regression (WA-PLS). The resulting coefficient of determination r2 between observed and predicted conductivity values (0.72) and the root-mean-square error of prediction (RMSEP) in % gradient length (13.1) indicate that conductivity may be reliably estimated from ostracod assemblage data. The transfer function was first applied to last glacial ostracod assemblage data from an archaeological trench in the Sea of Galilee (northern Israel). Relatively large conductivity fluctuations between ca 1 and 7 mS cm-1 were inferred for the period 24-20 cal ka BP. In addition, four episodes of freshwater influx near the site of the trench were identified from the presence of shells of freshwater and stream-dwelling species intermingled with very abundant shells of Cyprideis torosa. The results of our study allow a better use of Quaternary ostracods from the Levant as palaeoenvironmental indicators of water-body types and past conductivity levels and will contribute to a better understanding of Quaternary environmental and climate change in the Levant.

Vibrational energy on surfaces: Ultrafast flash-thermal conductance of molecular monolayers

NASA Astrophysics Data System (ADS)

Dlott, Dana

2008-03-01

Vibrational energy flow through molecules remains a perennial problem in chemical physics. Usually vibrational energy dynamics are viewed through the lens of time-dependent level populations. This is natural because lasers naturally pump and probe vibrational transitions, but it is also useful to think of vibrational energy as being conducted from one location in a molecule to another. We have developed a new technique where energy is driven into a specific part of molecules adsorbed on a metal surface, and ultrafast nonlinear coherent vibrational spectroscopy is used to watch the energy arrive at another part. This technique is the analog of a flash thermal conductance apparatus, except it probes energy flow with angstrom spatial and femtosecond temporal resolution. Specific examples to be presented include energy flow along alkane chains, and energy flow into substituted benzenes. Ref: Z. Wang, J. A. Carter, A. Lagutchev, Y. K. Koh, N.-H. Seong, D. G. Cahill, and D. D. Dlott, Ultrafast flash thermal conductance of molecular chains, Science 317, 787-790 (2007). This material is based upon work supported by the National Science Foundation under award DMR 0504038 and the Air Force Office of Scientific Research under award FA9550-06-1-0235.

Teachers' opinion about learning continuum based on student's level of competence and specific pedagogical material in classification topics

NASA Astrophysics Data System (ADS)

Andriani, Aldina Eka; Subali, Bambang

2017-08-01

This research discusses learning continuum development for designing a curriculum. The objective of this study is to gather the opinion of public junior and senior high school teachers about learning continuum based on student's level of competence and specific pedagogical material in classification topics. This research was conducted in Yogyakarta province from October 2016 to January 2017. This research utilizes a descriptive survey method. Respondents in this study consist of 281 science teachers at junior and senior high school in Yogyakarta city and 4 regencies namely Sleman, Bantul, Kulonprogo, and Gunung Kidul. The sample were taken using a census. The collection of data used questionnaire that had been validated from the aspects of construct validity and experts judgements. Data were analyzed using a descriptive analysis technique. The results of the analysis show that the opinions of teachers regarding specific pedagogical material in classification topics of living things at the junior high school taught in grade VII to the ability level of C2 (Understanding). At senior high school level, it is taught in grade X with the ability level C2 (Understanding). Based on these results, it can be concluded that the opinions of teachers still refer to the current syllabus and curriculum so that the teachers do not have pure opinions about the student's competence level in classification topics that should be taught at the level of the grade in accordance with the level of corresponding competency.

Chemical quality of water in abandoned zinc mines in northeastern Oklahoma and southeastern Kansas

USGS Publications Warehouse

Playton, Stephen J.; Davis, Robert Ellis; McClaflin, Roger G.

1978-01-01

Onsite measurements of pH, specific conductance, and water temperature show that water temperatures in seven mine shafts in northeastern Oklahoma and southeastern Kansas is stratified. With increasing sampling depth, specific conductance and water temperature tend to increase, and pH tends to decrease. Concentrations of dissolved solids and chemical constituents in mine-shaft water, such as total, and dissolved metals and dissolved sulfate also increase with depth. The apparently unstable condition created by cooler, denser water overlying warmer, less-dense water is offset by the greater density of the lower water strata due to higher dissolved solids content.Correlation analysis showed that several chemical constituents and properties of mine-shaft water, including dissolved solids, total hardness, and dissolved sulfate, calcium, magnesium, and lithium, are linearly related to specific conductance. None of the constituents or properties of mine-shaft water tested had a significant linear relationship to pH. However, when values of dissolved aluminum, zinc, and nickel were transformed to natural or Napierian logarithms, significant linear correlation to pH resulted. During the course of the study - September 1975 to June 1977 - the water level in a well penetrating the mine workings rose at an average rate of 1.2 feet per month.  Usually, the rate of water-level rise was greater than average after periods of relatively high rainfall, and lower than average during periods of relatively low rainfall.Water in the mine shafts is unsuited for most uses without treatment.  The inability of current domestic water treatment practices to remove high concentrations of toxic metals, such as cadmium and lead, precludes use of the water for a public supply.

Evaluation of Amount of Blood in Dry Blood Spots: Ring-Disk Electrode Conductometry.

PubMed

Kadjo, Akinde F; Stamos, Brian N; Shelor, C Phillip; Berg, Jordan M; Blount, Benjamin C; Dasgupta, Purnendu K

2016-06-21

A fixed area punch in dried blood spot (DBS) analysis is assumed to contain a fixed amount of blood, but the amount actually depends on a number of factors. The presently preferred approach is to normalize the measurement with respect to the sodium level, measured by atomic spectrometry. Instead of sodium levels, we propose electrical conductivity of the extract as an equivalent nondestructive measure. A dip-type small diameter ring-disk electrode (RDE) is ideal for very small volumes. However, the conductance (G) measured by an RDE depends on the depth (D) of the liquid below the probe. There is no established way of computing the specific conductance (σ) of the solution from G. Using a COMSOL Multiphysics model, we were able to obtain excellent agreement between the measured and the model predicted conductance as a function of D. Using simulations over a large range of dimensions, we provide a spreadsheet-based calculator where the RDE dimensions are the input parameters and the procedure determines the 99% of the infinite depth conductance (G99) and the depth D99 at which this is reached. For typical small diameter probes (outer electrode diameter ∼ <2 mm), D99 is small enough for dip-type measurements in extract volumes of ∼100 μL. We demonstrate the use of such probes with DBS extracts. In a small group of 12 volunteers (age 20-66), the specific conductance of 100 μL aqueous extracts of 2 μL of spotted blood showed a variance of 17.9%. For a given subject, methanol extracts of DBS spots nominally containing 8 and 4 μL of blood differed by a factor of 1.8-1.9 in the chromatographically determined values of sulfate and chloride (a minor and major constituent, respectively). The values normalized with respect to the conductance of the extracts differed by ∼1%. For serum associated analytes, normalization of the analyte value by the extract conductance can thus greatly reduce errors from variations in the spotted blood volume/unit area.

Monitoring of Sparta Aquifer Recovery in Southern Arkansas and Northern Louisiana, 2003-07

USGS Publications Warehouse

Freiwald, David A.; Johnson, Sherrel F.

2007-01-01

Prior to 2004, the Sparta aquifer supplied all water for industrial and municipal uses in Union County, Arkansas, and continues to provide the majority of water for industrial and municipal purposes in the surrounding southern Arkansas counties and northern Louisiana parishes. In Union County, the Sparta aquifer has been used increasingly since development began in the early 1920s, resulting in water-level declines of more than 360 feet (ft) near El Dorado, Arkansas. In addition, water quality in some areas of the Sparta aquifer has degraded with increased withdrawals. In 2002 a study began that measures, through monitoring and reporting of water levels in Sparta aquifer wells throughout the study area in southern Arkansas and northern Louisiana, the impact of conservation and alternative water efforts on water level and water quality. This study provides continuous real-time water-level data at eight USGS wells that are part of a network of 29 monitoring wells and periodically reports results of semi-annual water-quality sampling. Water levels have risen in all eight real-time wells since monitoring began in the summer of 2003, and the Ouachita River Alternative Water Supply Project was completed in September 2004. The largest water-level rises occurred between October 2004 and April 2007 in the Monsanto well (49.0 ft rise) just north of El Dorado, and the Welcome Center well (36.1 ft rise) southeast of El Dorado. Twelve wells were sampled semi-annually for specific conductance and chloride concentration. Average specific conductance from individual wells ranges from 216 in the northwest to 1,157 uS/cm in the southeast and average chloride concentration ranges from 3.2 to 214 mg/L.

Can carbon nanotube fibers achieve the ultimate conductivity?—Coupled-mode analysis for electron transport through the carbon nanotube contact

NASA Astrophysics Data System (ADS)

Xu, Fangbo; Sadrzadeh, Arta; Xu, Zhiping; Yakobson, Boris I.

2013-08-01

Recent measurements of carbon nanotube (CNT) fibers electrical conductivity still show the values lower than that of individual CNTs, by about one magnitude order. The imperfections of manufacturing process and constituent components are described as culprits. What if every segment is made perfect? In this work, we study the quantum conductance through the parallel junction of flawless armchair CNTs using tight-binding method in conjunction with non-equilibrium Green's function approach. Short-range oscillations within the long-range oscillations as well as decaying envelopes are all observed in the computed Fermi-level (low bias) conductance as a function of contact length, L. The propagation of CNTs' Bloch waves is cast in the coupled-mode formalism and helps to reveal the quantum interference nature of various behaviors of conductance. Our analysis shows that the Bloch waves at the Fermi-level propagate through a parallel junction without reflection only at an optimal value of contact length. For quite a long junction, however, the conductance at the Fermi level diminishes due to the perturbation of periodic potential field of close-packed CNTs. Thus, a macroscopic fiber, containing an infinite number of junctions, forms a filter that permits passage of electrons with specific wave vectors, and these wave vectors are determined by the collection of all the junction lengths. We also argue that the energy gap introduced by long junctions can be overcome by small voltage (˜0.04 V) across the whole fiber. Overall, developing long individual all-armchair metallic CNTs serves as a promising way to the manufacture of high-conductivity fibers.

Estimates of hydraulic properties from a one-dimensional numerical model of vertical aquifer-system deformation, Lorenzi site, Las Vegas, Nevada

USGS Publications Warehouse

Pavelko, Michael T.

2004-01-01

Land subsidence related to aquifer-system compaction and ground-water withdrawals has been occurring in Las Vegas Valley, Nevada, since the 1930's, and by the late 1980's some areas in the valley had subsided more than 5 feet. Since the late 1980's, seasonal artificial-recharge programs have lessened the effects of summertime pumping on aquifer-system compaction, but the long-term trend of compaction continues in places. Since 1994, the U.S. Geological Survey has continuously monitored water-level changes in three piezometers and vertical aquifer-system deformation with a borehole extensometer at the Lorenzi site in Las Vegas, Nevada. A one-dimensional, numerical, ground-water flow model of the aquifer system below the Lorenzi site was developed for the period 1901-2000, to estimate aquitard vertical hydraulic conductivity, aquitard inelastic skeletal specific storage, and aquitard and aquifer elastic skeletal specific storage. Aquifer water-level data were used in the model as the aquifer-system stresses that controlled simulated vertical aquifer-system deformation. Nonlinear-regression methods were used to calibrate the model, utilizing estimated and measured aquifer-system deformation data to minimize a weighted least-squares objective function, and estimate optimal property values. Model results indicate that at the Lorenzi site, aquitard vertical hydraulic conductivity is 3 x 10-6 feet per day, aquitard inelastic skeletal specific storage is 4 x 10-5 per foot, aquitard elastic skeletal specific storage is 5 x 10-6 per foot, and aquifer elastic skeletal specific storage is 3 x 10-7 per foot. Regression statistics indicate that the model and data provided sufficient information to estimate the target properties, the model adequately simulated observed data, and the estimated property values are accurate and unique.

Correlates of disease-specific knowledge in Chinese patients with COPD.

PubMed

Wong, Carlos Kh; Yu, W C

2016-01-01

This study aimed to determine the associations of various sociodemographic factors with the level of disease-specific knowledge among Hong Kong Chinese patients with COPD. A cross-sectional survey of 100 Chinese adults with COPD recruited from outpatient clinics was conducted from September 2009 to September 2010. Data on the knowledge specific to COPD and patients' sociodemographics were collected from face-to-face interviews. Primary outcome of disease-specific knowledge was measured using 65-item Bristol COPD Knowledge Questionnaire (BCKQ), summing up the 65 items as the BCKQ overall score. Associations of sociodemographic factors with the BCKQ overall score were evaluated using the linear regression model. The mean BCKQ overall score of our patients was 41.01 (SD: 10.64). The knowledge in topics of "Smoking" and "Phlegm" achieved the first (3.97, SD: 0.82) and second (3.91, SD: 1.17) highest mean scores, respectively, while the topic of "Oral steroids" returned the lowest mean score of 1.89 (SD: 1.64). The BCKQ overall score progressively declined ( P <0.001) with increase in education level, with the highest BCKQ overall score of 46.71 at no formal education among all subgroups. Compared to nondrinkers, current drinkers were associated with lower total BCKQ score. We found that among COPD patients in outpatient clinics, impairments in the level of COPD knowledge were evident in patients who were current drinkers or had higher level of education.

Gender recognition depends on type of movement and motor skill. Analyzing and perceiving biological motion in musical and nonmusical tasks.

PubMed

Wöllner, Clemens; Deconinck, Frederik J A

2013-05-01

Gender recognition in point-light displays was investigated with regard to body morphology cues and motion cues of human motion performed with different levels of technical skill. Gestures of male and female orchestral conductors were recorded with a motion capture system while they conducted excerpts from a Mendelssohn string symphony to musicians. Point-light displays of conductors were presented to observers under the following conditions: visual-only, auditory-only, audiovisual, and two non-conducting conditions (walking and static images). Observers distinguished between male and female conductors in gait and static images, but not in visual-only and auditory-only conducting conditions. Across all conductors, gender recognition for audiovisual stimuli was better than chance, yet significantly less reliable than for gait. Separate analyses for two groups of conductors indicated an expertise effect in that novice conductors' gender was perceived above chance level for visual-only and audiovisual conducting, while skilled conducting gestures of experts did not afford gender-specific cues. In these conditions, participants may have ignored the body morphology cues that led to correct judgments for static images. Results point to a response bias such that conductors were more often judged to be male. Thus judgment accuracy depended both on the conductors' level of expertise as well as on the observers' concepts, suggesting that perceivable differences between men and women may diminish for highly trained movements of experienced individuals. Copyright © 2013 Elsevier B.V. All rights reserved.

Episode-specific drinking-to-cope motivation, daily mood, and fatigue-related symptoms among college students.

PubMed

Armeli, Stephen; O'Hara, Ross E; Ehrenberg, Ethan; Sullivan, Tami P; Tennen, Howard

2014-09-01

The goal of the present study was to examine whether within-person, episode-specific changes in drinking-to-cope (DTC) motivation from the previous evening were associated with concurrent daily mood and fatigue-related symptoms among college student drinkers (N = 1,421; 54% female). We conducted an Internet-based daily diary study in which students reported over 30 days on their previous night's drinking level and motivation and their current mood (i.e., sadness, anxiety, anger/hostility, and positive mood) and fatigue-related symptoms. Hypotheses were tested using hierarchical linear models in which the current day's outcome was predicted by last night's levels of DTC motivation and drinking, controlling for drinking to enhance motivation, sex, current day's physical symptoms and drinking, and yesterday's level of the outcome. Subsequent models also predicted outcomes 2 days following the drinking event. Relative increases in previous night's DTC motivation were associated with higher levels of current day negative mood and fatigue-related symptoms and lower levels of positive mood. Also, the association between episode-specific DTC motivation and negative mood was stronger in the positive direction when individuals reported higher levels of nonsocial drinking from the previous night. Last, episode-specific DTC showed similar associations with sadness and anger/hostility 2 days after the drinking event. The results are generally consistent with the posited attention allocation and ego-depletion mechanisms. Findings suggest that the deleterious effects of repeated episodes of DTC, over time, could help to explain the increased likelihood of alcohol-related problems seen in prior studies.

1H-MRS in autism spectrum disorders: a systematic meta-analysis.

PubMed

Ipser, Jonathan C; Syal, Supriya; Bentley, Judy; Adnams, Colleen M; Steyn, Bennie; Stein, Dan J

2012-09-01

We conducted a systematic review and meta-analysis of proton magnetic resonance spectroscopy (1H-MRS) studies comparing autism spectrum disorder (ASD) patients with healthy controls, with the aim of profiling ASD-associated changes in the metabolites N-acetyl-aspartate (NAA) and Creatine (Cr). Meta-regression models of NAA and Cr levels were employed, using data from 20 eligible studies (N = 852), to investigate age-dependent differences in both global brain and region-specific metabolite levels, while controlling for measurement method (Cr-ratio versus absolute concentrations). Decreased NAA concentrations that were specific to children were found for whole-brain grey and white matter. In addition, a significant decrease in NAA was evident across age categories in the parietal cortex, the cerebellum, and the anterior cingulate cortex. Higher levels of Cr were observed for ASD adults than children in global grey matter, with specific increases for adults in the temporal lobe and decreased Cr in the occipital lobe in children. No differences were found for either NAA or Cr in the frontal lobes. These data provide some evidence that ASD is characterized by age-dependent fluctuations in metabolite levels across the whole brain and at the level of specific regions thought to underlie ASD-associated behavioural and affective deficits. Differences in Cr as a function of age and brain region suggests caution in the interpretation of Cr-based ratio measures of metabolites. Despite efforts to control for sources of heterogeneity, considerable variability in metabolite levels was observed in frontal and temporal regions, warranting further investigation.

Oxidative stability and ignition quality of algae derived methyl esters containing varying levels of methyl eicosapentaenoate and methyl docosahexaenoate

NASA Astrophysics Data System (ADS)

Bucy, Harrison

Microalgae is currently receiving strong consideration as a potential biofuel feedstock to help meet the advanced biofuels mandate of the 2007 Energy Independence and Security Act because of its theoretically high yield (gallons/acre/year) in comparison to current terrestrial feedstocks. Additionally, microalgae also do not compete with food and can be cultivated with wastewater on non-arable land. Microalgae lipids can be converted into a variety of biofuels including fatty acid methyl esters (e.g. FAME biodiesel), renewable diesel, renewable gasoline, or jet fuel. For microalgae derived FAME, the fuel properties will be directly related to the fatty acid composition of the lipids produced by the given microalgae strain. Several microalgae species under consideration for wide scale cultivation, such as Nannochloropsis, produce lipids with fatty acid compositions containing substantially higher quantities of long chainpolyunsaturated fatty acids (LC-PUFA) in comparison to terrestrial feedstocks. It is expected that increased levels of LC-PUFA will be problematic in terms of meeting all of the current ASTM specifications for biodiesel. For example, it is known that oxidative stability and cetane number decrease with increasing levels of LC-PUFA. However, these same LC-PUFA fatty acids, such as eicosapentaenoic acid (EPA: C20:5) and docosahexaenoic acid (DHA: C22:6) are known to have high nutritional value thereby making separation of these compounds economically attractive. Given the uncertainty in the future value of these LC-PUFA compounds and the economic viability of the separation process, the goal of this study was to examine the oxidative stability and ignition quality of algae-based FAME with varying levels of EPA and DHA removal. Oxidative stability tests were conducted at a temperature of 110°C and airflow of 10 L/h using a Metrohm 743 Rancimat with automatic induction period determination following the EN 14112 Method from the ASTM D6751 and EN 14214 Standards, which call for induction periods of at least three hours and six hours, respectively. Derived Cetane Number testing was conducted using a Waukesha FIT following the ASTM D7170 Method. Tests were conducted with synthetic algal oil blends manufactured from various sources to match the fatty acid compositions of several algae strains subjected to varying removal amounts of roughly 0 -- 100 percent LC-PUFA. In addition, tests were also conducted with real algal methyl esters produced from multiple sources. The bis-allylic position equivalent (BAPE) was calculated for each fuel sample to quantify the level of unsaturation. The induction period was then plotted as a function of BAPE, which showed that the oxidative stability varied exponentially with the amount of LC-PUFA. The results suggest that removal of 45 -- 65 percent of the LC-PUFA from Nannochloropsis-based algal methyl esters would be sufficient for meeting existing ASTM specifications for oxidative stability and 75 -- 85 percent removal would be needed to meet the EN specification. The oxidative stability additive tert-butylhydroquinone (THBQ) was found to increase Nannochloropsis-based algal methyl esters' oxidative stability to ASTM and EN specifications at only 0.03 percent and 0.06 percent additions by mass, respectively, when no LC-PUFA was removed. The ignition quality tests showed that the Derived Cetane Number varied linearly with BAPE and the algae formulations were found to pass the ASTM cetane specification of 47 only if all the LC-PUFA were removed.

Utilization of genetic tests: analysis of gene-specific billing in Medicare claims data.

PubMed

Lynch, Julie A; Berse, Brygida; Dotson, W David; Khoury, Muin J; Coomer, Nicole; Kautter, John

2017-08-01

We examined the utilization of precision medicine tests among Medicare beneficiaries through analysis of gene-specific tier 1 and 2 billing codes developed by the American Medical Association in 2012. We conducted a retrospective cross-sectional study. The primary source of data was 2013 Medicare 100% fee-for-service claims. We identified claims billed for each laboratory test, the number of patients tested, expenditures, and the diagnostic codes indicated for testing. We analyzed variations in testing by patient demographics and region of the country. Pharmacogenetic tests were billed most frequently, accounting for 48% of the expenditures for new codes. The most common indications for testing were breast cancer, long-term use of medications, and disorders of lipid metabolism. There was underutilization of guideline-recommended tumor mutation tests (e.g., epidermal growth factor receptor) and substantial overutilization of a test discouraged by guidelines (methylenetetrahydrofolate reductase). Methodology-based tier 2 codes represented 15% of all claims billed with the new codes. The highest rate of testing per beneficiary was in Mississippi and the lowest rate was in Alaska. Gene-specific billing codes significantly improved our ability to conduct population-level research of precision medicine. Analysis of these data in conjunction with clinical records should be conducted to validate findings.Genet Med advance online publication 26 January 2017.

Comparative case-control study of homocysteine, vitamin B12, and folic acid levels in patients with epilepsy.

PubMed

Pulido Fontes, L; Pulido Fontes, M; Quesada Jiménez, P; Muruzabal Pérez, J; Mendioroz Iriarte, M

2017-09-01

Increased blood homocysteine levels are a known cardiovascular risk factor. Epileptic patients on long-term treatment with antiepileptic drugs may present higher homocysteine levels and, consequently, a potential increase in cardiovascular risk. We conducted an observational case-control study to compare plasma levels of homocysteine, folic acid, and vitamin B 12 . Our study included a total of 88 subjects: 52 patients with epilepsy and 36 controls. Epileptic patients showed higher homocysteine levels (P=.084) and lower levels of folic acid (P<.05). Homocysteine levels should be monitored in epileptic patients on long-term treatment with antiepileptic drugs. We suggest starting specific treatment in patients with high homocysteine levels. Copyright © 2016 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

Evaluating lake stratification and temporal trends by using near-continuous water-quality data from automated profiling systems for water years 2005-09, Lake Mead, Arizona and Nevada

USGS Publications Warehouse

Veley, Ronald J.; Moran, Michael J.

2012-01-01

The U.S. Geological Survey, in cooperation with the National Park Service and Southern Nevada Water Authority, collected near-continuous depth-dependent water-quality data at Lake Mead, Arizona and Nevada, as part of a multi-agency monitoring network maintained to provide resource managers with basic data and to gain a better understanding of the hydrodynamics of the lake. Water-quality data-collection stations on Lake Mead were located in shallow water (less than 20 meters) at Las Vegas Bay (Site 3) and Overton Arm, and in deep water (greater than 20 meters) near Sentinel Island and at Virgin and Temple Basins. At each station, near-continual depth-dependent water-quality data were collected from October 2004 through September 2009. The data were collected by using automatic profiling systems equipped with multiparameter water-quality sondes. The sondes had sensors for temperature, specific conductance, dissolved oxygen, pH, turbidity, and depth. Data were collected every 6 hours at 2-meter depth intervals (for shallow-water stations) or 5-meter depth intervals (for deep-water stations) beginning at 1 meter below water surface. Data were analyzed to determine water-quality conditions related to stratification of the lake and temporal trends in water-quality parameters. Three water-quality parameters were the main focus of these analyses: temperature, specific conductance, and dissolved oxygen. Statistical temporal-trend analyses were performed for a single depth at shallow-water stations [Las Vegas Bay (Site 3) and Overton Arm] and for thermally-stratified lake layers at deep-water stations (Sentinel Island and Virgin Basin). The limited period of data collection at the Temple Basin station prevented the application of statistical trend analysis. During the summer months, thermal stratification was not observed at shallow-water stations, nor were major maxima or minima observed for specific-conductance or dissolved-oxygen profiles. A clearly-defined thermocline and well-defined maxima and minima in specific-conductance and dissolved-oxygen profiles were observed at deep-water stations during the summer months. Specific-conductance maxima were likely the result of inflow of water from either the Las Vegas Wash or Muddy/Virgin Rivers or both, while the minima were likely the result of inflow of water from the Colorado River. Maxima and minima for dissolved oxygen were likely the result of primary productivity blooms and their subsequent decay. Temporal-trend analyses indicated that specific conductance decreased at all stations over the period of record, except for Las Vegas Bay (Site 3), where specific conductance increased. Temperature also decreased over the period of record at deep-water stations for certain lake layers. Decreasing temperature and specific conductance at deep-water stations is the result of decreasing values in these parameters in water coming from the Colorado River. Quagga mussels (Dreissena rostriformis bugensis), however, could play a role in trends of decreasing specific conductance through incorporation of calcite in their shells. Trends of decreasing turbidity and pH at deep-water stations support the hypothesis that quagga mussels could be having an effect on the physical properties and water chemistry of Lake Mead. Unlike other stations, Las Vegas Bay (Site 3) had increasing specific conductance and is interpreted as the result of lowering lake levels decreasing the volume of lake water available for mixing and dilution of the high-conductance water coming from Las Vegas Wash. Dissolved oxygen increased over the period of record in some lake layers at the deep-water stations. Increasing dissolved oxygen at deep-water stations is believed to result, in part, from a reduction of phosphorus entering Lake Mead and the concomitant reduction of biological oxygen demand.

Preparation and visible-light photocatalytic properties of BiNbO₄ and BiTaO₄ by a citrate method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhai, Hai-Fa, E-mail: haifazhai@126.com; Li, Ai-Dong, E-mail: adli@nju.edu.cn; Kong, Ji-Zhou

2013-06-01

Visible-light photcatalysts of BiNbO₄ and BiTaO₄ powders have been successfully synthesized by a citrate method. The formation of pure triclinic phase of BiNbO₄ and BiTaO₄ at low temperature of 700 °C can be attributed to the advantage of the citrate method. The photocatalytic activity and possible mechanism were investigated deeply. For BiNbO₄ particles, the mechanism of methyl violet (MV) degradation under visible light irradiation involves photocatalytic and photosensitization pathways and the catalyst specific surface area has dominant influence. While for BiTaO₄ particles, the dominant mechanism arises from photosensitization pathways and a trade off between high specific surface area and goodmore » crystallinity is achieved. BiNbO₄ powder calcined at 700 °C shows the best photocatalytic efficiency among these catalysts, which is ascribed to its large surface area and more positive conduction band level. The optimal catalyst loading, additive H₂O₂ concentration and pH value is around 1 g/L, 2 mmol/L and 8 mmol/L, respectively. - Graphical abstract: Photodegradation performance and adsorption ability of BiNbO₄ and BiTaO₄ powders, respectively. BNO700 with the best photocatalytic efficiency is ascribed to its large surface area and more positive conduction band level. Highlights: • Pure BiNbO₄ and BiTaO₄ powders were prepared by a citrate method. • Excellent performance of visible-light degradation of MV was observed. • Different MV degradation mechanism for BiNbO₄ and BiTaO₄ powders was proposed. • BNO700 has large surface area and more positive conduction band level.« less

The Effect of Media on Citizens' Fear of Crime in Turkey

ERIC Educational Resources Information Center

Erdonmez, Erhan

2009-01-01

This study was conducted on-site in Istanbul, Turkey, to determine the effects that mass media has on citizens' perceptions about fear of crime, in particular, and fear, in general. Specifically, the study was designed to (1) determine the tendency of citizens' media consumption, (2) determine the level of fear of crime among Turkish citizens, (3)…

Physical Education Resources, Class Management, and Student Physical Activity Levels: A Structure-Process-Outcome Approach to Evaluating Physical Education Effectiveness

ERIC Educational Resources Information Center

Bevans, Katherine B.; Fitzpatrick, Leslie-Anne; Sanchez, Betty M.; Riley, Anne W.; Forrest, Christopher

2010-01-01

Background: This study was conducted to empirically evaluate specific human, curricular, and material resources that maximize student opportunities for physical activity during physical education (PE) class time. A structure-process-outcome model was proposed to identify the resources that influence the frequency of PE and intensity of physical…

"It's Different Now:" How Exit Exams Are Affecting Teaching and Learning in Jackson and Austin

ERIC Educational Resources Information Center

Zabala, Dalia; Minnici, Angela; Kober, Nancy, Ed.

2007-01-01

Since much of the previous research on exit exams, including CEP's own work, has looked at national patterns of implementation and passing rates, this study aimed to benefit policy and practice by focusing on the local level. Specifically, case studies were conducted in Jackson, MS and Austin, TX that examined how classroom instruction and other…

English Textbooks for Russian Students: Problems and Specific Features

ERIC Educational Resources Information Center

Solnyshkina, Marina I.; Vishnyakova, Ol'ga D.; Gafiyatova, Elzara V.; Gabitov, Azat I.

2017-01-01

The research identifies the complexity level of eight texts from Spotlight 11 used in Russian TEFL to prepare students for National Unified Exam in English and assess their reading skills. The results of the analyses conducted with the help of T.E.R.A., an automated text processor, prove that all texts fell within the range of 6-9 Flesch-Kincaid…

Integrated Advanced Microwave Sounding Unit-A (AMSU-A). Performance Verification Report: METSAT AMSU-A2 Antenna Drive Subsystem, P/N 1331200-2, S/N 106

NASA Technical Reports Server (NTRS)

Higgins, T.

1998-01-01

An antenna drive subsystem test was performed on the METSAT AMSU-A2 S/N 106 instrument. The objective of the test was to demonstrate compliance with applicable paragraphs of AMSU-A specifications S480-80. Tests were conducted at both the subassembly and instrument level.

State Level Intelligence Doctrine: Bridging the Gap

DTIC Science & Technology

2013-12-01

intelligence operations that transcend the local/federal membrane and perceived glass ceilings . Currently, articles specifically give New York state police...oriented policing to most effectively conduct domestic intelligence operations. Currently, most state and local fusion centers operate as a...and effective as guidance and direction is clearly defined and prescribed. RESEARCH QUESTION How can state police agencies, in conjunction with DHS

Closing the Loop or Jumping through Hoops: The Impact of Assessment on the Legal Studies Curricula

ERIC Educational Resources Information Center

Steslow, Donna; Lasher, Nancy; Kong, Sue

2016-01-01

While assessment is normally conducted at a programmatic (degree, or institution-wide) level, it is interesting and informative to learn where specific courses fit into assessment and how those courses have been adjusted in response to data collected in the assessment process. As members of the Academy of Legal Studies in Business (ALSB), the…

Rural People and Their Resources: North-Central New Mexico.

ERIC Educational Resources Information Center

Taylor, Marlowe M.

The general objective of a study conducted in the 1950's was to describe the physical and human resources of the rural areas in north-central New Mexico. The specific objectives were (1) to inventory and classify the land, labor, and capital resources, (2) to determine levels and sources of incomes of these households, and (3) to appraise some of…

Moving First-Year Writing Online: Applying Social Cognitive Theory to an Exploration of Student Study Habits and Interactions

ERIC Educational Resources Information Center

Rendahl, Merry A.

2010-01-01

This dissertation explores study habits and interactions of students in an online first-year writing course. Much research has been conducted about online learning, but little has focused specifically on first-year writing students. First-year writing presents some unique challenges because of the age and preparedness level of traditional…

Learning Disabilities: Current Policy and Directions for Community Involvement among the Arab Community in Israel

ERIC Educational Resources Information Center

Jabareen-Taha, Samaher; Taha, Haitham

2016-01-01

This article seeks to identify and review the basic characteristics of learning disability which are specifically mentioned in the literature. In addition, the article intends to conduct a brief analysis on learning disability policy in Israel and the differentiation problems at the level of awareness among the Arab society in Israel. Despite the…

Nanoporous metal/oxide hybrid electrodes for electrochemical supercapacitors

NASA Astrophysics Data System (ADS)

Lang, Xingyou; Hirata, Akihiko; Fujita, Takeshi; Chen, Mingwei

2011-04-01

Electrochemical supercapacitors can deliver high levels of electrical power and offer long operating lifetimes, but their energy storage density is too low for many important applications. Pseudocapacitive transition-metal oxides such as MnO2 could be used to make electrodes in such supercapacitors, because they are predicted to have a high capacitance for storing electrical charge while also being inexpensive and not harmful to the environment. However, the poor conductivity of MnO2 (10-5-10-6 S cm-1) limits the charge/discharge rate for high-power applications. Here, we show that hybrid structures made of nanoporous gold and nanocrystalline MnO2 have enhanced conductivity, resulting in a specific capacitance of the constituent MnO2 (~1,145 F g-1) that is close to the theoretical value. The nanoporous gold allows electron transport through the MnO2, and facilitates fast ion diffusion between the MnO2 and the electrolytes while also acting as a double-layer capacitor. The high specific capacitances and charge/discharge rates offered by such hybrid structures make them promising candidates as electrodes in supercapacitors, combining high-energy storage densities with high levels of power delivery.

Nanoporous metal/oxide hybrid electrodes for electrochemical supercapacitors.

PubMed

Lang, Xingyou; Hirata, Akihiko; Fujita, Takeshi; Chen, Mingwei

2011-04-01

Electrochemical supercapacitors can deliver high levels of electrical power and offer long operating lifetimes, but their energy storage density is too low for many important applications. Pseudocapacitive transition-metal oxides such as MnO(2) could be used to make electrodes in such supercapacitors, because they are predicted to have a high capacitance for storing electrical charge while also being inexpensive and not harmful to the environment. However, the poor conductivity of MnO(2) (10(-5)-10(-6) S cm(-1)) limits the charge/discharge rate for high-power applications. Here, we show that hybrid structures made of nanoporous gold and nanocrystalline MnO(2) have enhanced conductivity, resulting in a specific capacitance of the constituent MnO(2) (~1,145 F g(-1)) that is close to the theoretical value. The nanoporous gold allows electron transport through the MnO(2), and facilitates fast ion diffusion between the MnO(2) and the electrolytes while also acting as a double-layer capacitor. The high specific capacitances and charge/discharge rates offered by such hybrid structures make them promising candidates as electrodes in supercapacitors, combining high-energy storage densities with high levels of power delivery.

Hydrologic data for Block Island, Rhode Island

USGS Publications Warehouse

Burns, Emily

1993-01-01

This report was compiled as part of a study to assess the hydrogeology and the quality and quantity of fresh ground water on Block Island, Rhode Island. Hydrologic data were collected on Block Island during 1988-91. The data are pre- sented in illustrations and tables. Data collec- ted include precipitation, surfae-water, ground- water, lithologic, and well-construction and dis- charge information. Precipitation data include total monthly precipitation values from 11 rain gages and water-quality analyses of 14 precipi- tation samples from one station. Surface-water data include water-level measurements at 12 ponds, water-quality data for five ponds, and field specific-conductance measurements at 56 surface- water sites (streams, ponds, and springs). Ground- water data include water-level measurements at 159 wells, water-quality data at 150 wells, and field specific-conductance data at 52 wells. Lithologic logs for 375 wells and test borings, and construc- tion and location data for 570 wells, springs, and test borings are included. In addition, the data set contains data on water quality of water samples, collected by the Rhode Island Department of Health during 1976-91, from Fresh and Sands Ponds and from wells at the Block Island Water Company well field north of Sands Pond.

Effect of low-level copper and pentachlorophenol exposure on various early life stages of Xenopus laevis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fort, D.J.; Stover, E.L.

1996-12-31

An evaluation of the effects of low-level copper and pentachlorophenol exposure on various early life stages of the South African clawed frog, Xenopus laevis, was performed using stage-specific and long-term continuous exposures. Stage-specific exposure experiments were conducted such that separate subsets of embryos and larvae from the same clutch were exposed to two toxicants, copper and pentachlorphenol, from 0 d to 4 d (standard Frog Embryo Teratogenesis Assay--Xenopus [FETAX]), 4 d to 8 d, 8 d to 12 d, and 12 d to 16 d. Results from two separate concentration-response experiments indicated that sensitivity to either toxicant increased in eachmore » successive time period. Longer-term exposure studies conducted for 60 to 75 days indicated that copper, but not pentachlorophenol induced reduction deficiency malformations of the hind limb at concentrations as low as 0.05 mg/L. Pentachlorophenol concentrations as low as 0.5 {micro}g/L inhibited tail resorption. However, copper did not adversely affect the process of tail resorption. These results indicated that studies evaluating longer-term developmental processes are important in ecological hazard evaluation.« less

Climate-water quality relationships in Texas reservoirs

USGS Publications Warehouse

Gelca, Rodica; Hayhoe, Katharine; Scott-Fleming, Ian; Crow, Caleb; Dawson, D.; Patino, Reynaldo

2015-01-01

Water temperature, dissolved oxygen, and concentrations of salts in surface water bodies can be affected by the natural environment, local human activities such as surface and ground water withdrawals, land use, and energy extraction, and variability and long-term trends in atmospheric conditions including temperature and precipitation. Here, we quantify the relationship between 121 indicators of mean and extreme temperature and precipitation and 24 water quality parameters in 57 Texas reservoirs using observational data records covering the period 1960 to 2010. We find that water temperature, dissolved oxygen, pH, specific conductance, chloride, sulfate, and phosphorus all show consistent correlations with atmospheric predictors, including high and low temperature extremes, dry days, heavy precipitation events, and mean temperature and precipitation over time scales ranging from one week to two years. Based on this analysis and published future projections for this region, we expect climate change to increase water temperatures, decrease dissolved oxygen levels, decrease pH, increase specific conductance, and increase levels of sulfate, chloride in Texas reservoirs. Over decadal time scales, this may affect aquatic ecosystems in the reservoirs, including altering the risk of conditions conducive to algae occurrence, as well as affecting the quality of water available for human consumption and recreation.

Chemical composition and variability of the waters of the Edwards Plateau, central Texas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Groeger, A.W.; Gustafson, J.J.

1994-12-31

The surface waters of the karstic Edwards Plateau, southcentral Texas, are quite similar in many of their chemical characteristics. The ionic composition of the water was dominated by calcium and alkalinity (mostly bicarbonate) acquired through limestone weathering, and the ionic composition (in equivalents) was Ca>Mg>Na>K and alkalinity >Cl and SO{sub 4}. The median specific conductance and total dissolved solids ranged from 394 to 535 {mu}S cm{sup {minus}1} and 220 and 327 mg L{sup {minus}1}, respectively. The streams were always near or at supersaturation with respect to calcium carbonate, and the dynamics of calcium carbonate dissolution and precipitation tended to maintainmore » the dissolved substances at a fairly constant level. This may have been enhanced by the intimate contact of water and bedrock characteristic of karst drainages. Specific conductance, Ca, and alkalinity all decreased at higher summer temperatures. Many of the streams on the plateau maintained a constant level or actually increased concentrations of total dissolved substances at increased flow rates. These waters acquired significant quantities of solute as they flow through the confine Edwards Aquifer, including alkalinity, Ca, Mg, Na, Cl, and NO{sub 3}.« less

Generative mechanistic explanation building in undergraduate molecular and cellular biology

NASA Astrophysics Data System (ADS)

Southard, Katelyn M.; Espindola, Melissa R.; Zaepfel, Samantha D.; Bolger, Molly S.

2017-09-01

When conducting scientific research, experts in molecular and cellular biology (MCB) use specific reasoning strategies to construct mechanistic explanations for the underlying causal features of molecular phenomena. We explored how undergraduate students applied this scientific practice in MCB. Drawing from studies of explanation building among scientists, we created and applied a theoretical framework to explore the strategies students use to construct explanations for 'novel' biological phenomena. Specifically, we explored how students navigated the multi-level nature of complex biological systems using generative mechanistic reasoning. Interviews were conducted with introductory and upper-division biology students at a large public university in the United States. Results of qualitative coding revealed key features of students' explanation building. Students used modular thinking to consider the functional subdivisions of the system, which they 'filled in' to varying degrees with mechanistic elements. They also hypothesised the involvement of mechanistic entities and instantiated abstract schema to adapt their explanations to unfamiliar biological contexts. Finally, we explored the flexible thinking that students used to hypothesise the impact of mutations on multi-leveled biological systems. Results revealed a number of ways that students drew mechanistic connections between molecules, functional modules (sets of molecules with an emergent function), cells, tissues, organisms and populations.

The search for an elusive cutoff remains: Problems of binary classification of heavy drinking as an endpoint for alcohol clinical trials.

PubMed

Pearson, Matthew R; Bravo, Adrian J; Kirouac, Megan; Witkiewitz, Katie

2017-02-01

To examine whether a clinically meaningful alcohol consumption cutoff can be created for clinical samples, we used receiver operator characteristic (ROC) curves to derive gender-specific consumption cutoffs that maximized sensitivity and specificity in the prediction of a wide range of negative consequences from drinking. We conducted secondary data analyses using data from two large clinical trials targeting alcohol use disorders: Project MATCH (n=1726) and COMBINE (n=1383). In both studies, we found that the ideal cutoff for men and women that maximized sensitivity/specificity varied substantially both across different alcohol consumption variables and alcohol consequence outcomes. Further, the levels of sensitivity/specificity were poor across all consequences. These results fail to provide support for a clinically meaningful alcohol consumption cutoff and suggest that binary classification of levels of alcohol consumption is a poor proxy for maximizing sensitivity/specificity in the prediction of negative consequences from drinking. Future research examining consumption-consequence associations should take advantage of continuous measures of alcohol consumption and alternative approaches for assessing the link between levels of consumption and consequences (e.g., ecological momentary assessment). Clinical researchers should consider focusing more directly on the consequences they aim to reduce instead of relying on consumption as a proxy for more clinically meaningful outcomes. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

The Search for an Elusive Cutoff Remains: Problems of Binary Classification of Heavy Drinking as an Endpoint for Alcohol Clinical Trials

PubMed Central

Pearson, Matthew R.; Bravo, Adrian J.; Kirouac, Megan; Witkiewitz, Katie

2017-01-01

Background To examine whether a clinically meaningful alcohol consumption cutoff can be created for clinical samples, we used receiver operator characteristic (ROC) curves to derive gender-specific consumption cutoffs that maximized sensitivity and specificity in the prediction of a wide range of negative consequences from drinking. Methods We conducted secondary data analyses using data from two large clinical trials targeting alcohol use disorders: Project MATCH (n = 1,726) and COMBINE (n = 1,383). Results In both studies, we found that the ideal cutoff for men and women that maximized sensitivity/specificity varied substantially both across different alcohol consumption variables and alcohol consequence outcomes. Further, the levels of sensitivity/specificity were poor across all consequences. Conclusions These results fail to provide support for a clinically meaningful alcohol consumption cutoff and suggest that binary classification of levels of alcohol consumption is a poor proxy for maximizing sensitivity/specificity in the prediction of negative consequences from drinking. Future research examining consumption-consequence associations should take advantage of continuous measures of alcohol consumption and alternative approaches for assessing the link between levels of consumption and consequences (e.g., ecological momentary assessment). Clinical researchers should consider focusing more directly on the consequences they aim to reduce instead of relying on consumption as a proxy for more clinically meaningful outcomes. PMID:28038361

H2 arcjet performance mapping program

NASA Astrophysics Data System (ADS)

1992-01-01

Work performed during the period of Mar. 1991 to Jan. 1992 is reviewed. High power H2 arcjets are being considered for electric powered orbit transfer vehicles (EOTV). Mission analyses indicate that the overall arcjet thrust efficiency is very important since increasing the efficiency increases the thrust, and thereby reduces the total trip time for the same power. For example, increasing the thrust efficiency at the same specific impulse from 30 to 40 percent will reduce the trip time by 25 percent. For a 200 day mission, this equates to 50 days, which results in lower ground costs and less time during which the payload is dormant. Arcjet performance levels of 1200 seconds specific impulse (lsp) at 35 to 40 percent efficiency with lifetimes over 1000 hours are needed to support EOTV missions. Because of the potential very high efficiency levels, the objective of this program was to evaluate the ability of a scaled Giannini-style thruster to achieve the performance levels while operating at a reduced nominal power of 10 kW. To meet this objective, a review of past literature was conducted; scaling relationships were developed and applied to establish critical dimensions; a development thruster was designed with the aid of the plasma analysis model KARNAC and finite element thermal modeling; test hardware was fabricated; and a series of performance tests were conducted in RRC's Cell 11 vacuum chamber with its null-balance thrust stand.

Bilayer lipid composition modulates the activity of dermaseptins, polycationic antimicrobial peptides.

PubMed

Duclohier, Hervé

2006-05-01

The primary targets of defense peptides are plasma membranes, and the induced irreversible depolarization is sufficient to exert antimicrobial activity although secondary modes of action might be at work. Channels or pores underlying membrane permeabilization are usually quite large with single-channel conductances two orders of magnitude higher than those exhibited by physiological channels involved, e.g., in excitability. Accordingly, the ion specificity and selectivity are quite low. Whereas, e.g., peptaibols favor cation transport, polycationic or basic peptides tend to form anion-specific pores. With dermaseptin B2, a 33 residue long and mostly alpha-helical peptide isolated from the skin of the South American frog Phyllomedusa bicolor, we found that the ion specificity of its pores induced in bilayers is modulated by phospholipid-charged headgroups. This suggests mixed lipid-peptide pore lining instead of the more classical barrel-stave model. Macroscopic conductance is nearly voltage independent, and concentration dependence suggests that the pores are mainly formed by dermaseptin tetramers. The two most probable single-channel events are well resolved at 200 and 500 pS (in 150 mM NaCl) with occasional other equally spaced higher or lower levels. In contrast to previous molecular dynamics previsions, this study demonstrates that dermaseptins are able to form pores, although a related analog (B6) failed to induce any significant conductance. Finally, the model of the pore we present accounts for phospholipid headgroups intercalated between peptide helices lining the pore and for one of the most probable single-channel conductance.

Current evaluation of the tripropellant concept

NASA Technical Reports Server (NTRS)

Zurawski, R. L.

1986-01-01

An analytical study was conducted to determine the specific-impulse advantages of adding metals to conventional liquid-bipropellant systems. These tripropellant systems theoretically offer higher specific impulse and increased propellant density compared with bipropellant systems. Metals considered were Be, Li, and Al. Bipropellant systems were H2/O2, N2H4/N2O4, RP-1/O2, and H2/F2. Thermochemical calculations were performed for sea-level expansion from 6.895-MN/sq. m. (1000-psia) chamber pressure over a wide range of mixture ratios and propellant compositions. Three-dimensional plots characterize the specific impulse of each tripropellant system. Technology issues pertinent to metallized propellant systems are discussed.

Impact of Multifunctional Bimetallic Materials on Lithium Battery Electrochemistry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Durham, Jessica L.; Poyraz, Altug S.; Takeuchi, Esther S.

Electric energy storage devices such as batteries are complex systems comprised of a variety of materials with each playing separate yet interactive roles, complicated by length scale interactions occurring from the molecular to the mesoscale. Thus, addressing specific battery issues such as functional capacity requires a comprehensive perspective initiating with atomic level concepts. For example, the electroactive materials which contribute to the functional capacity in a battery comprise approximately 30% or less of the total device mass. Thus, the design and implementation of multifunctional materials can conceptually reduce or eliminate the contribution of passive materials to the size and massmore » of the final system. Material multi-functionality can be achieved through appropriate material design on the atomic level resulting in bimetallic electroactive materials where one metal cation forms mesoscale conductive networks upon discharge while the other metal cation can contribute to atomic level structure and net functional secondary capacity, a device level issue. Specifically, this Account provides insight into the multi-mechanism electrochemical redox processes of bimetallic cathode materials based on transition metal oxides (MM’O) or phosphorous oxides (MM’PO) where M = Ag and M’ = V or Fe. One discharge process can be described as reduction-displacement where Ag + is reduced to Ag 0 and displaced from the parent structure. This reduction-displacement reaction in silver-containing bimetallic electrodes allows for the in-situ formation of a conductive network, enhancing the electrochemical performance of the electrode and reducing or eliminating the need for conductive additives. A second discharge process occurs through the reduction of the second transition metal, V or Fe, where the oxidation state of the metal center is reduced and lithium cations are inserted into the structure. As both metal centers contribute to the functional capacity, determining the kinetically and thermodynamically preferred reduction processes at various states of discharge is critical to elucidating the mechanism. Specific advanced in-situ and ex-situ characterization techniques are conducive to gaining insight regarding the electrochemical behavior of these multifunctional materials over multiple length scales. At the material level, optical microscopy, scanning electron microscopy, and local conductivity measurement via a nanoprobe can track the discharge mechanism of an isolated single particle. At the mesoscale electrode level, in-situ data from synchrotron based energy dispersive X-ray diffraction (EDXRD) within fully intact steel batteries can be used to spatially map the distribution of silver metal generated through reduction displacement as a function of discharge depth and discharge rate. As illustrated here, appropriate design of materials with multiple electrochemically active metal centers and properties tuned through strategically conceptualized materials synthesis may provide a path toward the next generation of high energy content electroactive materials and systems. In conclusion, full understanding of the multiple electrochemical mechanisms can be achieved only by utilizing advanced characterization tools over multiple length scales.« less

Impact of Multifunctional Bimetallic Materials on Lithium Battery Electrochemistry

DOE PAGES

Durham, Jessica L.; Poyraz, Altug S.; Takeuchi, Esther S.; ...

2016-08-26

Electric energy storage devices such as batteries are complex systems comprised of a variety of materials with each playing separate yet interactive roles, complicated by length scale interactions occurring from the molecular to the mesoscale. Thus, addressing specific battery issues such as functional capacity requires a comprehensive perspective initiating with atomic level concepts. For example, the electroactive materials which contribute to the functional capacity in a battery comprise approximately 30% or less of the total device mass. Thus, the design and implementation of multifunctional materials can conceptually reduce or eliminate the contribution of passive materials to the size and massmore » of the final system. Material multi-functionality can be achieved through appropriate material design on the atomic level resulting in bimetallic electroactive materials where one metal cation forms mesoscale conductive networks upon discharge while the other metal cation can contribute to atomic level structure and net functional secondary capacity, a device level issue. Specifically, this Account provides insight into the multi-mechanism electrochemical redox processes of bimetallic cathode materials based on transition metal oxides (MM’O) or phosphorous oxides (MM’PO) where M = Ag and M’ = V or Fe. One discharge process can be described as reduction-displacement where Ag + is reduced to Ag 0 and displaced from the parent structure. This reduction-displacement reaction in silver-containing bimetallic electrodes allows for the in-situ formation of a conductive network, enhancing the electrochemical performance of the electrode and reducing or eliminating the need for conductive additives. A second discharge process occurs through the reduction of the second transition metal, V or Fe, where the oxidation state of the metal center is reduced and lithium cations are inserted into the structure. As both metal centers contribute to the functional capacity, determining the kinetically and thermodynamically preferred reduction processes at various states of discharge is critical to elucidating the mechanism. Specific advanced in-situ and ex-situ characterization techniques are conducive to gaining insight regarding the electrochemical behavior of these multifunctional materials over multiple length scales. At the material level, optical microscopy, scanning electron microscopy, and local conductivity measurement via a nanoprobe can track the discharge mechanism of an isolated single particle. At the mesoscale electrode level, in-situ data from synchrotron based energy dispersive X-ray diffraction (EDXRD) within fully intact steel batteries can be used to spatially map the distribution of silver metal generated through reduction displacement as a function of discharge depth and discharge rate. As illustrated here, appropriate design of materials with multiple electrochemically active metal centers and properties tuned through strategically conceptualized materials synthesis may provide a path toward the next generation of high energy content electroactive materials and systems. In conclusion, full understanding of the multiple electrochemical mechanisms can be achieved only by utilizing advanced characterization tools over multiple length scales.« less

Weavable, Conductive Yarn-Based NiCo//Zn Textile Battery with High Energy Density and Rate Capability.

PubMed

Huang, Yan; Ip, Wing Shan; Lau, Yuen Ying; Sun, Jinfeng; Zeng, Jie; Yeung, Nga Sze Sea; Ng, Wing Sum; Li, Hongfei; Pei, Zengxia; Xue, Qi; Wang, Yukun; Yu, Jie; Hu, Hong; Zhi, Chunyi

2017-09-26

With intrinsic safety and much higher energy densities than supercapacitors, rechargeable nickel/cobalt-zinc-based textile batteries are promising power sources for next generation personalized wearable electronics. However, high-performance wearable nickel/cobalt-zinc-based batteries are rarely reported because there is a lack of industrially weavable and knittable highly conductive yarns. Here, we use scalably produced highly conductive yarns uniformly covered with zinc (as anode) and nickel cobalt hydroxide nanosheets (as cathode) to fabricate rechargeable yarn batteries. They possess a battery level capacity and energy density, as well as a supercapacitor level power density. They deliver high specific capacity of 5 mAh cm -3 and energy densities of 0.12 mWh cm -2 and 8 mWh cm -3 (based on the whole solid battery). They exhibit ultrahigh rate capabilities of 232 C (liquid electrolyte) and 116 C (solid electrolyte), which endows the batteries excellent power densities of 32.8 mW cm -2 and 2.2 W cm -3 (based on the whole solid battery). These are among the highest values reported so far. A wrist band battery is further constructed by using a large conductive cloth woven from the conductive yarns by a commercial weaving machine. It powers various electronic devices successfully, enabling dual functions of wearability and energy storage.

Record-high specific conductance and water temperature in San Francisco Bay during water year 2015

USGS Publications Warehouse

Work, Paul A.; Downing-Kunz, Maureen; Livsey, Daniel N.

2017-02-22

The San Francisco estuary is commonly defined to include San Francisco Bay (bay) and the adjacent Sacramento–San Joaquin River Delta (delta). The U.S. Geological Survey (USGS) has operated a high-frequency (15-minute sampling interval) water-quality monitoring network in San Francisco Bay since the late 1980s (Buchanan and others, 2014). This network includes 19 stations at which sustained measurements have been made in the bay; currently, 8 stations are in operation (fig. 1). All eight stations are equipped with specific conductance (which can be related to salinity) and water-temperature sensors. Water quality in the bay constantly changes as ocean tides force seawater in and out of the bay, and river inflows—the most significant coming from the delta—vary on time scales ranging from those associated with storms to multiyear droughts. This monitoring network was designed to observe and characterize some of these changes in the bay across space and over time. The data demonstrate a high degree of variability in both specific conductance and temperature at time scales from tidal to annual and also reveal longer-term changes that are likely to influence overall environmental health in the bay.In water year (WY) 2015 (October 1, 2014, through September 30, 2015), as in the preceding water year (Downing-Kunz and others, 2015), the high-frequency measurements revealed record-high values of specific conductance and water temperature at several stations during a period of reduced freshwater inflow from the delta and other tributaries because of persistent, severe drought conditions in California. This report briefly summarizes observations for WY 2015 and compares them to previous years that had different levels of freshwater inflow.

Effects of correlated hybridization in the single-impurity Anderson model

NASA Astrophysics Data System (ADS)

Líbero, Valter; Veiga, Rodrigo

2013-03-01

The development of new materials often dependents on the theoretical foundations which study the microscopic matter, i.e., the way atoms interact and create distinct configurations. Among the interesting materials, those with partially filled d or f orbitals immersed in nonmagnetic metals have been described by the Anderson model, which takes into account Coulomb correlation (U) when a local level (energy Ed) is doubled occupied, and an electronic hybridization between local levels and conduction band states. In addition, here we include a correlated hybridization term, which depends on the local-level occupation number involved. This term breaks particle-hole symmetry (even when U + 2Ed = 0), enhances charge fluctuations on local levels and as a consequence strongly modifies the crossover between the Hamiltonian fixed-points, even suppressing one or other. We exemplify these behaviors showing data obtained from the Numerical Renormalization Group (NRG) computation for the impurity temperature-dependent specific heat, entropy and magnetic susceptibility. The interleaving procedure is used to recover the continuum spectrum after the NRG-logarithmic discretization of the conduction band. Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP.

Origins of Fermi-level pinning on GaN and InN polar and nonpolar surfaces

NASA Astrophysics Data System (ADS)

Segev, D.; Van de Walle, C. G.

2006-10-01

Using band structure and total energy methods, we study the atomic and electronic structures of the polar (+c and - c plane) and nonpolar (a and m plane) surfaces of GaN and InN. We identify two distinct microscopic origins for Fermi-level pinning on GaN and InN, depending on surface stoichiometry and surface polarity. At moderate Ga/N ratios unoccupied gallium dangling bonds pin the Fermi level on n-type GaN at 0.5 0.7 eV below the conduction-band minimum. Under highly Ga-rich conditions metallic Ga adlayers lead to Fermi-level pinning at 1.8 eV above the valence-band maximum. We also explain the source of the intrinsic electron accumulation that has been universally observed on polar InN surfaces. It is caused by In-In bonds leading to occupied surface states above the conduction-band minimum. We predict that such a charge accumulation will be absent on the nonpolar surfaces of InN, when prepared under specific conditions.

The role of anisotropic thermal conduction in a collisionless magnetized hot accretion flow

NASA Astrophysics Data System (ADS)

Ghasemnezhad, Maryam

2018-06-01

We study the importance and the effects of anisotropic thermal conduction in a collisionless magnetized advection dominated accretion flow in the presence of discontinuity of mass, angular momentum and energy between inflow and outflow. In this paper, we have considered that the thermal conduction is a heating mechanism like viscosity and leads to an increase in the temperature of the gas. A set of self similar solutions are used for steady state and axisymmetric structure of such hot accretion disc to solve the MHD equations in our model. Based on these solutions, we have found that increasing the level of two parts of anisotropic thermal conduction (parallel & transverse) results in increasing the mass accretion rate or radial velocity but decreasing the rotational velocity. Also both radial and rotational velocities are sub-Keplerian. Also we have shown that the anisotropic thermal conduction can be effective in the parameter space of specific energy of outflow, toroidal and vertical components of magnetic field according to a physical constraint tinfall ≥ t⊥, conduction.

Opportunities for State-Level Action to Reduce Firearm Violence: Proceeding From the Evidence

PubMed Central

Braga, Anthony A.

2011-01-01

Firearm violence remains an important problem, and a large body of evidence shows that guns used in crime follow generally predictable paths from manufacturer to criminal end user. Policy initiatives based on that evidence have been shown to be effective. A recently published study conducted by a leading policy organization presents new evidence and makes specific recommendations for action by state-level policymakers. Unfortunately, the study's analysis is overly simplified, and the recommendations are therefore misleading. We suggest alternatives that are evidence based. PMID:21778510

Corrosion of radioactive waste tanks containing washed sludge and precipitates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bickford, D.F.; Congdon, J.W.; Oblath, S.B.

1988-05-01

At the US Department of Energy (DOE) Savannah River Plant, the corrosion of carbon steel storage tanks containing alkaline, high-level radioactive waste is controlled by specification of limits on waste composition and temperature. Laboratory tests, conducted to determine minimum corrosion inhibitor levels, indicated pitting of carbon steel near the waterline for proposed storage conditions. In situ electrochemical measurements of full-scale radioactive process demonstrations were conducted to assess the validity of laboratory tests. The in situ results are compared to those of laboratory tests, with particular regard given to simulated solution composition. Transition metal hydroxide sludge contains strong passivating species formore » carbon steel. Washed precipitate contains organic species that lower solution pH and tend to reduce passivating films, requiring higher inhibitor concentrations than the 0.01 M nitrite required for reactor fuel reprocessing wastes.« less

Absence of Association between Cord Specific Antibody Levels and Severe Respiratory Syncytial Virus (RSV) Disease in Early Infants: A Case Control Study from Coastal Kenya.

PubMed

Nyiro, Joyce Uchi; Sande, Charles Jumba; Mutunga, Martin; Kiyuka, Patience Kerubo; Munywoki, Patrick Kioo; Scott, John Anthony G; Nokes, David James

2016-01-01

The target group for severe respiratory syncytial virus (RSV) disease prevention is infants under 6 months of age. Vaccine boosting of antibody titres in pregnant mothers could protect these young infants from severe respiratory syncytial virus (RSV) associated disease. Quantifying protective levels of RSV-specific maternal antibody at birth would inform vaccine development. A case control study nested in a birth cohort (2002-07) was conducted in Kilifi, Kenya; where 30 hospitalised cases of RSV-associated severe disease were matched to 60 controls. Participants had a cord blood and 2 subsequent 3-monthly blood samples assayed for RSV-specific neutralising antibody by the plaque reduction neutralisation test (PRNT). Two sample paired t test and conditional logistic regression were used in analyses of log2PRNT titres. The mean RSV log2PRNT titre at birth for cases and controls were not significantly different (P = 0.4) and remained so on age-stratification. Cord blood PRNT titres showed considerable overlap between cases and controls. The odds of RSV disease decreased with increase in log2PRNT cord blood titre. There was a 30% reduction in RSV disease per unit increase in log2PRNT titre (<3months age group) but not significant (P = 0.3). From this study, there is no strong evidence of protection by maternal RSV specific antibodies from severe RSV disease. Cord antibody levels show wide variation with considerable overlap between cases and controls. It is likely that, there are additional factors to specific PRNT antibody levels which determine susceptibility to severe RSV disease. In addition, higher levels of neutralizing antibody beyond the normal range may be required for protection; which it is hoped can be achieved by a maternal RSV vaccine.

The Relationship Between Population-Level Exposure to Alcohol Advertising on Television and Brand-Specific Consumption Among Underage Youth in the US

PubMed Central

Ross, Craig S.; Maple, Emily; Siegel, Michael; DeJong, William; Naimi, Timothy S.; Padon, Alisa A.; Borzekowski, Dina L.G.; Jernigan, David H.

2015-01-01

Aims: We investigated the population-level relationship between exposure to brand-specific advertising and brand-specific alcohol use among US youth. Methods: We conducted an internet survey of a national sample of 1031 youth, ages 13–20, who had consumed alcohol in the past 30 days. We ascertained all of the alcohol brands respondents consumed in the past 30 days, as well as which of 20 popular television shows they had viewed during that time period. Using a negative binomial regression model, we examined the relationship between aggregated brand-specific exposure to alcohol advertising on the 20 television shows [ad stock, measured in gross rating points (GRPs)] and youth brand-consumption prevalence, while controlling for the average price and overall market share of each brand. Results: Brands with advertising exposure on the 20 television shows had a consumption prevalence about four times higher than brands not advertising on those shows. Brand-level advertising elasticity of demand varied by exposure level, with higher elasticity in the lower exposure range. The estimated advertising elasticity of 0.63 in the lower exposure range indicates that for each 1% increase in advertising exposure, a brand's youth consumption prevalence increases by 0.63%. Conclusions: At the population level, underage youths' exposure to brand-specific advertising was a significant predictor of the consumption prevalence of that brand, independent of each brand's price and overall market share. The non-linearity of the observed relationship suggests that youth advertising exposure may need to be lowered substantially in order to decrease consumption of the most heavily advertised brands. PMID:25754127

The relationship between population-level exposure to alcohol advertising on television and brand-specific consumption among underage youth in the US.

PubMed

Ross, Craig S; Maple, Emily; Siegel, Michael; DeJong, William; Naimi, Timothy S; Padon, Alisa A; Borzekowski, Dina L G; Jernigan, David H

2015-05-01

We investigated the population-level relationship between exposure to brand-specific advertising and brand-specific alcohol use among US youth. We conducted an internet survey of a national sample of 1031 youth, ages 13-20, who had consumed alcohol in the past 30 days. We ascertained all of the alcohol brands respondents consumed in the past 30 days, as well as which of 20 popular television shows they had viewed during that time period. Using a negative binomial regression model, we examined the relationship between aggregated brand-specific exposure to alcohol advertising on the 20 television shows [ad stock, measured in gross rating points (GRPs)] and youth brand-consumption prevalence, while controlling for the average price and overall market share of each brand. Brands with advertising exposure on the 20 television shows had a consumption prevalence about four times higher than brands not advertising on those shows. Brand-level advertising elasticity of demand varied by exposure level, with higher elasticity in the lower exposure range. The estimated advertising elasticity of 0.63 in the lower exposure range indicates that for each 1% increase in advertising exposure, a brand's youth consumption prevalence increases by 0.63%. At the population level, underage youths' exposure to brand-specific advertising was a significant predictor of the consumption prevalence of that brand, independent of each brand's price and overall market share. The non-linearity of the observed relationship suggests that youth advertising exposure may need to be lowered substantially in order to decrease consumption of the most heavily advertised brands. © The Author 2015. Medical Council on Alcohol and Oxford University Press. All rights reserved.

Small Launch Vehicle Concept Development for Affordable Multi-Stage Inline Configurations

NASA Technical Reports Server (NTRS)

Beers, Benjamin R.; Waters, Eric D.; Philips, Alan D.; Threet, Grady E., Jr.

2014-01-01

The Advanced Concepts Office at NASA's George C. Marshall Space Flight Center conducted a study of two configurations of a three stage, inline, liquid propellant small launch vehicle concept developed on the premise of maximizing affordability by targeting a specific payload capability range based on current industry demand. The initial configuration, NESC-1, employed liquid oxygen as the oxidizer and rocket propellant grade kerosene as the fuel in all three stages. The second and more heavily studied configuration, NESC-4, employed liquid oxygen and rocket propellant grade kerosene on the first and second stages and liquid oxygen and liquid methane fuel on the third stage. On both vehicles, sensitivity studies were first conducted on specific impulse and stage propellant mass fraction in order to baseline gear ratios and drive the focus of concept development. Subsequent sensitivity and trade studies on the NESC-4 configuration investigated potential impacts to affordability due to changes in gross liftoff weight and/or vehicle complexity. Results are discussed at a high level to understand the severity of certain sensitivities and how those trade studies conducted can either affect cost, performance or both.

Small Launch Vehicle Concept Development for Affordable Multi-Stage Inline Configurations

NASA Technical Reports Server (NTRS)

Beers, Benjamin R.; Waters, Eric D.; Philips, Alan D.; Threet, Grady E. Jr.

2013-01-01

The Advanced Concepts Office at NASA's George C. Marshall Space Flight Center conducted a study of two configurations of a three-stage, inline, liquid propellant small launch vehicle concept developed on the premise of maximizing affordability by targeting a specific payload capability range based on current industry demand. The initial configuration, NESC-1, employed liquid oxygen as the oxidizer and rocket propellant grade kerosene as the fuel in all three stages. The second and more heavily studied configuration, NESC-4, employed liquid oxygen and RP-1 on the first and second stages and liquid oxygen and liquid methane fuel on the third stage. On both vehicles, sensitivity studies were first conducted on specific impulse and stage propellant mass fraction in order to baseline gear ratios and drive the focus of concept development. Subsequent sensitivity and trade studies on the NESC-4 concept investigated potential impacts to affordability due to changes in gross liftoff weight and/or vehicle complexity. Results are discussed at a high level to understand the impact severity of certain sensitivities and how those trade studies conducted can either affect cost, performance, or both.

Person-city personality fit and entrepreneurial success: An explorative study in China.

PubMed

Zhou, Mingjie; Zhou, Yixin; Zhang, Jianxin; Obschonka, Martin; Silbereisen, Rainer K

2017-08-13

While the study of personality differences is a traditional psychological approach in entrepreneurship research, economic research directs attention towards the entrepreneurial ecosystems in which entrepreneurial activity are embedded. We combine both approaches and quantify the interplay between the individual personality make-up of entrepreneurs and the local personality composition of ecosystems, with a special focus on person-city personality fit. Specifically, we analyse personality data from N = 26,405 Chinese residents across 42 major Chinese cities, including N = 1091 Chinese entrepreneurs. Multi-level polynomial regression and response surface plots revealed that: (a) individual-level conscientiousness had a positive effect and individual-level agreeableness and neuroticism had a negative effect on entrepreneurial success, (b) city-level conscientiousness had a positive, and city-level neuroticism had a negative effect on entrepreneurial success, and (c) additional person-city personality fit effects existed for agreeableness, conscientiousness and neuroticism. For example, entrepreneurs who are high in agreeableness and conduct their business in a city with a low agreeableness level show the lowest entrepreneurial success. In contrast, entrepreneurs who are low in agreeableness and conduct their business in a city with a high agreeableness level show relatively high entrepreneurial success. Implications for research and practice are discussed. © 2017 International Union of Psychological Science.

Evaluation of blood lead level in methamphetamine users in Tehran.

PubMed

Mostafazadeh, Babak; Shadnia, Shahin; Tavakkoli, Mohammad Ali; Khoddami Vishteh, Hamid Reza

2017-02-22

Given the increasing number of lead poisoning in opioids users and since no study has been conducted so far to review lead poisoning in methamphetamine (crystal) users, this study aimed to investigate blood lead level in methamphetamine addicts. This study was conducted on 20 patients with methamphetamine poisoning and their blood lead level was measured. The subjects were selected from among patients with a history of continuous use of methamphetamine, without a history of using opiates in the past 6 months confirmed by a negative urine tests, and without a history of heavy metal poisoning. Of all, 18 patients were male and the mean age was 32 ± 10 years; 17 patients were abusing the drug via inhalation and three persons via oral administration. The mean blood lead level was 2.3 ± 1.1 μg/dL and poisoning was not observed in any of the cases. Blood lead level was not associated with age, sex, dosage, and route of administration. Although blood lead level was not at poisoning level in people who only used methamphetamine in Iran, due to the simultaneous use of other substances and because of non-specific symptoms, lead poisoning must be suspected in all cases of substances poisoning.

A systematic review of validated methods for identifying acute respiratory failure using administrative and claims data.

PubMed

Jones, Natalie; Schneider, Gary; Kachroo, Sumesh; Rotella, Philip; Avetisyan, Ruzan; Reynolds, Matthew W

2012-01-01

The Food and Drug Administration's (FDA) Mini-Sentinel pilot program initially aims to conduct active surveillance to refine safety signals that emerge for marketed medical products. A key facet of this surveillance is to develop and understand the validity of algorithms for identifying health outcomes of interest (HOIs) from administrative and claims data. This paper summarizes the process and findings of the algorithm review of acute respiratory failure (ARF). PubMed and Iowa Drug Information Service searches were conducted to identify citations applicable to the anaphylaxis HOI. Level 1 abstract reviews and Level 2 full-text reviews were conducted to find articles using administrative and claims data to identify ARF, including validation estimates of the coding algorithms. Our search revealed a deficiency of literature focusing on ARF algorithms and validation estimates. Only two studies provided codes for ARF, each using related yet different ICD-9 codes (i.e., ICD-9 codes 518.8, "other diseases of lung," and 518.81, "acute respiratory failure"). Neither study provided validation estimates. Research needs to be conducted on designing validation studies to test ARF algorithms and estimating their predictive power, sensitivity, and specificity. Copyright © 2012 John Wiley & Sons, Ltd.

Clinical value of preoperative serum CA 19-9 and CA 125 levels in predicting the resectability of hilar cholangiocarcinoma.

PubMed

Hu, Hai-Jie; Mao, Hui; Tan, Yong-Qiong; Shrestha, Anuj; Ma, Wen-Jie; Yang, Qin; Wang, Jun-Ke; Cheng, Nan-Sheng; Li, Fu-Yu

2016-01-01

To examine the predictive value of tumor markers for evaluating tumor resectability in patients with hilar cholangiocarcinoma and to explore the prognostic effect of various preoperative factors on resectability in patients with potentially resectable tumors. Patients with potentially resectable tumors judged by radiologic examination were included. The receiver operating characteristic (ROC) analysis was conducted to evaluate serum carbohydrate antigenic determinant 19-9 (CA 19-9), carbohydrate antigen 125 (CA 125) and carcino embryonie antigen levels on tumor resectability. Univariate and multivariate logistic regression models were also conducted to analysis the correlation of preoperative factors with resectability. In patients with normal bilirubin levels, ROC curve analysis calculated the ideal CA 19-9 cut-off value of 203.96 U/ml in prediction of resectability, with a sensitivity of 83.7 %, specificity of 80 %, positive predictive value of 91.1 % and negative predictive value of 66.7 %. Meanwhile, the optimal cut-off value for CA 125 to predict resectability was 25.905 U/ml (sensitivity, 78.6 %; specificity, 67.5 %). In a multivariate logistic regression model, tumor size ≤3 cm (OR 4.149, 95 % CI 1.326-12.981, P = 0.015), preoperative CA 19-9 level ≤200 U/ml (OR 20.324, 95 % CI 6.509-63.467, P < 0.001), preoperative CA 125 levels ≤26 U/ml (OR 8.209, 95 % CI 2.624-25.677, P < 0.001) were independent determinants of resectability in patients diagnosed as hilar cholangiocarcinoma. Preoperative CA 19-9 and CA 125 levels predict resectability in patients with radiological resectable hilar cholangiocarcinoma. Increased preoperative CA 19-9 levels and CA 125 levels are associated with poor resectability rate.

Species-specific transpiration responses to intermediate disturbance in a northern hardwood forest: Transpiration response to disturbance

DOE PAGES

Matheny, Ashley M.; Bohrer, Gil; Vogel, Christoph S.; ...

2014-12-04

Intermediate disturbances shape forest structure and composition, which may in turn alter carbon, nitrogen, and water cycling. We used a large-scale experiment in a forest in northern lower Michigan where we prescribed an intermediate disturbance by stem girdling all canopy-dominant early successional trees to simulate an accelerated age-related senescence associated with natural succession.Using 3 years of eddy covariance and sap flux measurements in the disturbed area and an adjacent control plot, we analyzed disturbance-induced changes to plot level and species-specific transpiration and stomatal conductance. We found transpiration to be ~15% lower in disturbed plots than in unmanipulated control plots. However,more » species-specific responses to changes in microclimate varied. While red oak and white pine showed increases in stomatal conductance during post disturbance (62.5 and 132.2%, respectively), redmaple reduced stomatal conductance by 36.8%. We used the hysteresis between sap flux and vapor pressure deficit to quantify diurnal hydraulic stress incurred by each species in both plots. Red oak, a ring porousanisohydric species, demonstrated the largest mean relative hysteresis, while red maple, bigtooth aspen, andpaper birch, all diffuse porous species, had the lowest relative hysteresis. We employed the Penman-Monteithmodel for LE to demonstrate that these species-specific responses to disturbance are not well captured using current modeling strategies and that accounting for changes to leaf area index and plot microclimate are insufffcient to fully describe the effects of disturbance on transpiration.« less

Species-specific transpiration responses to intermediate disturbance in a northern hardwood forest

NASA Astrophysics Data System (ADS)

Matheny, Ashley M.; Bohrer, Gil; Vogel, Christoph S.; Morin, Timothy H.; He, Lingli; Frasson, Renato Prata de Moraes; Mirfenderesgi, Golnazalsadat; Schäfer, Karina V. R.; Gough, Christopher M.; Ivanov, Valeriy Y.; Curtis, Peter S.

2014-12-01

Intermediate disturbances shape forest structure and composition, which may in turn alter carbon, nitrogen, and water cycling. We used a large-scale experiment in a forest in northern lower Michigan where we prescribed an intermediate disturbance by stem girdling all canopy-dominant early successional trees to simulate an accelerated age-related senescence associated with natural succession. Using 3 years of eddy covariance and sap flux measurements in the disturbed area and an adjacent control plot, we analyzed disturbance-induced changes to plot level and species-specific transpiration and stomatal conductance. We found transpiration to be 15% lower in disturbed plots than in unmanipulated control plots. However, species-specific responses to changes in microclimate varied. While red oak and white pine showed increases in stomatal conductance during postdisturbance (62.5 and 132.2%, respectively), red maple reduced stomatal conductance by 36.8%. We used the hysteresis between sap flux and vapor pressure deficit to quantify diurnal hydraulic stress incurred by each species in both plots. Red oak, a ring porous anisohydric species, demonstrated the largest mean relative hysteresis, while red maple, bigtooth aspen, and paper birch, all diffuse porous species, had the lowest relative hysteresis. We employed the Penman-Monteith model for LE to demonstrate that these species-specific responses to disturbance are not well captured using current modeling strategies and that accounting for changes to leaf area index and plot microclimate are insufficient to fully describe the effects of disturbance on transpiration.

Generating level-dependent models of cervical and thoracic spinal cord injury: Exploring the interplay of neuroanatomy, physiology, and function.

PubMed

Wilcox, Jared T; Satkunendrarajah, Kajana; Nasirzadeh, Yasmin; Laliberte, Alex M; Lip, Alyssa; Cadotte, David W; Foltz, Warren D; Fehlings, Michael G

2017-09-01

The majority of spinal cord injuries (SCI) occur at the cervical level, which results in significant impairment. Neurologic level and severity of injury are primary endpoints in clinical trials; however, how level-specific damages relate to behavioural performance in cervical injury is incompletely understood. We hypothesized that ascending level of injury leads to worsening forelimb performance, and correlates with loss of neural tissue and muscle-specific neuron pools. A direct comparison of multiple models was made with injury realized at the C5, C6, C7 and T7 vertebral levels using clip compression with sham-operated controls. Animals were assessed for 10weeks post-injury with numerous (40) outcome measures, including: classic behavioural tests, CatWalk, non-invasive MRI, electrophysiology, histologic lesion morphometry, neuron counts, and motor compartment quantification, and multivariate statistics on the total dataset. Histologic staining and T1-weighted MR imaging revealed similar structural changes and distinct tissue loss with cystic cavitation across all injuries. Forelimb tests, including grip strength, F-WARP motor scale, Inclined Plane, and forelimb ladder walk, exhibited stratification between all groups and marked impairment with C5 and C6 injuries. Classic hindlimb tests including BBB, hindlimb ladder walk, bladder recovery, and mortality were not different between cervical and thoracic injuries. CatWalk multivariate gait analysis showed reciprocal and progressive changes forelimb and hindlimb function with ascending level of injury. Electrophysiology revealed poor forelimb axonal conduction in cervical C5 and C6 groups alone. The cervical enlargement (C5-T2) showed progressive ventral horn atrophy and loss of specific motor neuron populations with ascending injury. Multivariate statistics revealed a robust dataset, rank-order contribution of outcomes, and allowed prediction of injury level with single-level discrimination using forelimb performance and neuron counts. Level-dependent models were generated using clip-compression SCI, with marked and reliable differences in forelimb performance and specific neuron pool loss. Copyright © 2017 Elsevier Inc. All rights reserved.

Investigation of varying gray scale levels for remote manipulation

NASA Technical Reports Server (NTRS)

Bierschwale, John M.; Stuart, Mark A.; Sampaio, Carlos E.

1991-01-01

A study was conducted to investigate the effects of variant monitor gray scale levels and workplace illumination levels on operators' ability to discriminate between different colors on a monochrome monitor. It was determined that 8-gray scale viewing resulted in significantly worse discrimination performance compared to 16- and 32-gray scale viewing and that there was only a negligible difference found between 16 and 32 shades of gray. Therefore, it is recommended that monitors used while performing remote manipulation tasks have 16 or above shades of gray since this evaluation has found levels lower than this to be unacceptable for color discrimination task. There was no significant performance difference found between a high and a low workplace illumination condition. Further analysis was conducted to determine which specific combinations of colors can be used in conjunction with each other to ensure errorfree color coding/brightness discrimination performance while viewing a monochrome monitor. It was found that 92 three-color combination and 9 four-color combinations could be used with 100 percent accuracy. The results can help to determine which gray scale levels should be provided on monochrome monitors as well as which colors to use to ensure the maximal performance of remotely-viewed color discrimination/coding tasks.

Declines in arrestin and rhodopsin in the macula with progression of age-related macular degeneration.

PubMed

Ethen, Cheryl M; Feng, Xiao; Olsen, Timothy W; Ferrington, Deborah A

2005-03-01

Biochemical analysis of age-related macular degeneration (AMD) at distinct stages of the disease will help further understanding of the molecular events associated with disease progression. This study was conducted to determine the ability of a new grading system for eye bank eyes, the Minnesota Grading System (MGS), to discern distinct stages of AMD so that retinal region-specific changes in rod photoreceptor protein expression from donors could be determined. Donor eyes were assigned to a specific level of AMD by using the MGS. Expression of the rod photoreceptor proteins rhodopsin and arrestin was evaluated by Western immunoblot analysis in the macular and peripheral regions of the neurosensory retina from donors at different stages of AMD. A significant linear decline in both arrestin and rhodopsin content correlated with progressive MGS levels in the macula. In contrast, the peripheral region showed no significant correlation between MGS level and the content of either protein. The statistically significant relationship between decreasing macular rod photoreceptor proteins and progressive MGS levels of AMD demonstrates the utility of the clinically based MGS to correspond with specific protein changes found at known, progressive stages of degeneration. Future biochemical analysis of clinically characterized donor eyes will further understanding of the pathobiochemistry of AMD.

Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants contributing to lipid levels and coronary artery disease

PubMed Central

Lu, Xiangfeng; Peloso, Gina M; Liu, Dajiang J.; Wu, Ying; Zhang, He; Zhou, Wei; Li, Jun; Tang, Clara Sze-man; Dorajoo, Rajkumar; Li, Huaixing; Long, Jirong; Guo, Xiuqing; Xu, Ming; Spracklen, Cassandra N.; Chen, Yang; Liu, Xuezhen; Zhang, Yan; Khor, Chiea Chuen; Liu, Jianjun; Sun, Liang; Wang, Laiyuan; Gao, Yu-Tang; Hu, Yao; Yu, Kuai; Wang, Yiqin; Cheung, Chloe Yu Yan; Wang, Feijie; Huang, Jianfeng; Fan, Qiao; Cai, Qiuyin; Chen, Shufeng; Shi, Jinxiu; Yang, Xueli; Zhao, Wanting; Sheu, Wayne H.-H.; Cherny, Stacey Shawn; He, Meian; Feranil, Alan B.; Adair, Linda S.; Gordon-Larsen, Penny; Du, Shufa; Varma, Rohit; da Chen, Yii-Der I; Shu, XiaoOu; Lam, Karen Siu Ling; Wong, Tien Yin; Ganesh, Santhi K.; Mo, Zengnan; Hveem, Kristian; Fritsche, Lars; Nielsen, Jonas Bille; Tse, Hung-fat; Huo, Yong; Cheng, Ching-Yu; Chen, Y. Eugene; Zheng, Wei; Tai, E Shyong; Gao, Wei; Lin, Xu; Huang, Wei; Abecasis, Goncalo; Consortium, GLGC; Kathiresan, Sekar; Mohlke, Karen L.; Wu, Tangchun; Sham, Pak Chung; Gu, Dongfeng; Willer, Cristen J

2017-01-01

Most genome-wide association studies have been conducted in European individuals, even though most genetic variation in humans is seen only in non-European samples. To search for novel loci associated with blood lipid levels and clarify the mechanism of action at previously identified lipid loci, we examined protein-coding genetic variants in 47,532 East Asian individuals using an exome array. We identified 255 variants at 41 loci reaching chip-wide significance, including 3 novel loci and 14 East Asian-specific coding variant associations. After meta-analysis with > 300,000 European samples, we identified an additional 9 novel loci. The same 16 genes were identified by the protein-altering variants in both East Asians and Europeans, likely pointing to the functional genes. Our data demonstrate that most of the low-frequency or rare coding variants associated with lipids are population-specific, and that examining genomic data across diverse ancestries may facilitate the identification of functional genes at associated loci. PMID:29083407

Broad specification fuels technology program, phase 1

NASA Technical Reports Server (NTRS)

Lohmann, R. P.; Jeroszko, R. A.

1982-01-01

An experimental evaluation was conducted to assess the impact of the use of broadened properties fuels on combustor design concepts. Emphasis was placed on establishing the viability of design modifications to current combustor concepts and the use of advanced technology concepts to facilitate operation on Experimental Referee Broad Specification (ERBS) fuel while meeting exhaust emissions and performance specifications and maintaining acceptable durability. Three different combustor concepts, representative of progressively more aggressive technology levels, were evaluated. When operated on ERBS rather than Jet A fuel, a single stage combustor typical of that in the most recent versions of the JT9D-7 engine was found to produce excess carbon monoxide emissions at idle and elevated liner temperatures at high power levels that were projected to reduced liner life by 13 percent. The introduction of improved component technology, such as refined fuel injectors and advanced liner cooling concepts were shown to have the potential of enhancing the fuel flexibility of the single stage combustor.

A framework for sea level rise vulnerability assessment for southwest U.S. military installations

USGS Publications Warehouse

Chadwick, B.; Flick, Reinhard; Helly, J.; Nishikawa, Tracy; Pei, Fang Wang; O'Reilly, W.; Guza, R.; Bromirski, Peter; Young, A.; Crampton, W.; Wild, B.; Canner, I.

2011-01-01

We describe an analysis framework to determine military installation vulnerabilities under increases in local mean sea level as projected over the next century. The effort is in response to an increasing recognition of potential climate change ramifications for national security and recommendations that DoD conduct assessments of the impact on U.S. military installations of climate change. Results of the effort described here focus on development of a conceptual framework for sea level rise vulnerability assessment at coastal military installations in the southwest U.S. We introduce the vulnerability assessment in the context of a risk assessment paradigm that incorporates sources in the form of future sea level conditions, pathways of impact including inundation, flooding, erosion and intrusion, and a range of military installation specific receptors such as critical infrastructure and training areas. A unique aspect of the methodology is the capability to develop wave climate projections from GCM outputs and transform these to future wave conditions at specific coastal sites. Future sea level scenarios are considered in the context of installation sensitivity curves which reveal response thresholds specific to each installation, pathway and receptor. In the end, our goal is to provide a military-relevant framework for assessment of accelerated SLR vulnerability, and develop the best scientifically-based scenarios of waves, tides and storms and their implications for DoD installations in the southwestern U.S.

A systematic review of validated methods for identifying hypersensitivity reactions other than anaphylaxis (fever, rash, and lymphadenopathy), using administrative and claims data.

PubMed

Schneider, Gary; Kachroo, Sumesh; Jones, Natalie; Crean, Sheila; Rotella, Philip; Avetisyan, Ruzan; Reynolds, Matthew W

2012-01-01

The Food and Drug Administration's Mini-Sentinel pilot program aims to conduct active surveillance to refine safety signals that emerge for marketed medical products. A key facet of this surveillance is to develop and understand the validity of algorithms for identifying health outcomes of interest from administrative and claims data. This article summarizes the process and findings of the algorithm review of hypersensitivity reactions. PubMed and Iowa Drug Information Service searches were conducted to identify citations applicable to the hypersensitivity reactions of health outcomes of interest. Level 1 abstract reviews and Level 2 full-text reviews were conducted to find articles using administrative and claims data to identify hypersensitivity reactions and including validation estimates of the coding algorithms. We identified five studies that provided validated hypersensitivity-reaction algorithms. Algorithm positive predictive values (PPVs) for various definitions of hypersensitivity reactions ranged from 3% to 95%. PPVs were high (i.e. 90%-95%) when both exposures and diagnoses were very specific. PPV generally decreased when the definition of hypersensitivity was expanded, except in one study that used data mining methodology for algorithm development. The ability of coding algorithms to identify hypersensitivity reactions varied, with decreasing performance occurring with expanded outcome definitions. This examination of hypersensitivity-reaction coding algorithms provides an example of surveillance bias resulting from outcome definitions that include mild cases. Data mining may provide tools for algorithm development for hypersensitivity and other health outcomes. Research needs to be conducted on designing validation studies to test hypersensitivity-reaction algorithms and estimating their predictive power, sensitivity, and specificity. Copyright © 2012 John Wiley & Sons, Ltd.

The relationship between maternal self-efficacy and parenting practices: implications for parent training.

PubMed

Sanders, M R; Woolley, M L

2005-01-01

The present study examined the relationship between maternal self-efficacy, dysfunctional discipline practices and child conduct problems. Specifically, three levels of self-efficacy, global, domain and task-specific self-efficacy, were assessed in mothers of 2- to 8-year-old children with conduct problems (clinic group, n=45) and non-clinic mothers from the community (non-clinic group, n=79). Measures of global, domain and task-specific self-efficacy were completed by mothers. Clinic mothers reported significantly lower self-efficacy than non-clinic mothers for all but one of the parenting tasks assessed. Both groups of mothers reported lowest self-efficacy for similar parenting tasks. In the sample as a whole self-efficacy measures were significant predictors of maternal discipline style after controlling for other parent, child and risk factors. Of the self-efficacy variables behavioural self-efficacy was the best predictor of mothers discipline style. The findings support the importance of developing parenting strategies that enable parents to generalize their parenting skills to a diverse range of diverse parenting contexts both in the home and in the community.

American Recovery and Reinvestment Act (ARRA) FEMP Technical Assistance Federal Aviation Administration – Project 209 Control Tower and Support Building, Reno, Nevada

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arends, J.; Sandusky, William F.

2010-06-30

Pacific Northwest National Laboratory (PNNL) and Redhorse Corporation (Redhorse) conducted an energy audit on the Federal Aviation Administration (FAA) control tower and base building in Reno, Nevada. This report presents the findings of the energy audit team that evaluated construction documents and operating specifications (at the 100% level) and completed a site visit. The focus of the review was to identify measures that could be incorporated into the final design and operating specifications that would result in additional energy savings for the FAA that would not have otherwise occurred.

Comparative evaluation of two glycine transporter 1 radiotracers [11C]GSK931145 and [18F]MK-6577 in baboons.

PubMed

Zheng, Ming-Qiang; Lin, Shu-Fei; Holden, Daniel; Naganawa, Mika; Ropchan, Jim R; Najafzaden, Soheila; Kapinos, Michael; Tabriz, Mike; Carson, Richard E; Hamill, Terence G; Huang, Yiyun

2016-03-01

Glycine transporter type-1 (GlyT1) has been proposed as a target for drug development for schizophrenia. PET imaging with a GlyT1 specific radiotracer will allow for the measurement of target occupancy of GlyT1 inhibitors, and for in vivo investigation of GlyT1 alterations in schizophrenia. We conducted a comparative evaluation of two GlyT1 radiotracers, [(11) C]GSK931145, and [(18) F]MK-6577, in baboons. Two baboons were imaged with [(11) C]GSK931145 and [(18) F]MK-6577. Blocking studies with GSK931145 (0.3 or 0.2 mg/kg) were conducted to determine the level of tracer specific binding. [(11) C]GSK931145 and [(18) F]MK-6577 were synthesized in good yield and high specific activity. Moderately fast metabolism was observed for both tracers, with ∼ 30% of parent at 30 min post-injection. In the brain, both radiotracers showed good uptake and distribution profiles consistent with regional GlyT1 densities. [(18) F]MK-6577 displayed higher uptake and faster kinetics than [(11) C]GSK931145. Time activity curves were well described by the two-tissue compartment model. Regional volume of distribution (VT ) values were higher for [(18) F]MK-6577 than [(11) C]GSK931145. Pretreatment with GSK931145 reduced tracer uptake to a homogeneous level throughout the brain, indicating in vivo binding specificity and lack of a reference region for both radiotracers. Linear regression analysis of VT estimates between tracers indicated higher specific binding for [(18) F]MK-6577 than [(11) C]GSK931145, consistent with higher regional binding potential (BPND ) values of [(18) F]MK-6577 calculated using VT from the baseline scans and non-displaceable distribution volume (VND ) derived from blocking studies. [(18) F]MK-6577 appears to be a superior radiotracer with higher brain uptake, faster kinetics, and higher specific binding signals than [(11) C]GSK931145. © 2016 Wiley Periodicals, Inc.

Role of specific IgE and skin-prick testing in predicting food challenge results to baked egg

PubMed Central

Cortot, Catherine F.; Sheehan, William J.; Permaul, Perdita; Friedlander, James L.; Baxi, Sachin N.; Gaffin, Jonathan M.; Dioun, Anahita F.; Hoffman, Elaine B.; Schneider, Lynda C.

2012-01-01

Previous studies suggest that children with egg allergy may be able to tolerate baked egg. Reliable predictors of a successful baked egg challenge are not well established. We examined egg white–specific IgE levels, skin-prick test (SPT) results, and age as predictors of baked egg oral food challenge (OFC) outcomes. We conducted a retrospective chart review of children, aged 2–18 years, receiving an egg white–specific IgE level, SPT, and OFC to baked egg from 2008 to 2010. Fifty-two oral baked egg challenges were conducted. Of the 52 challenges, 83% (n = 43) passed and 17% (n = 9) failed, including 2 having anaphylaxis. Median SPT wheal size was 12 mm (range, 0–35 mm) for passed challenges and 17 mm (range, 10–30 mm) for failed challenges (p = 0.091). The negative predictive value for passing the OFC was 100% (9 of 9) if SPT wheal size was <10 mm. Median egg white–specific IgE was 2.02 kU/L (range, <0.35–13.00 kU/L) for passed challenges and 1.52 kU/L (range, 0.51–6.10 kU/L) for failed challenges (p = 0.660). Receiver operating characteristic (ROC) curve analysis for SPT revealed an area under the curve (AUC) of 0.64. ROC curve analysis for egg white–specific IgE revealed an AUC of 0.63. There was no significant difference in age between patients who failed and those who passed (median = 8.8 years versus 7.0 years; p = 0.721). Based on our sample, SPT, egg white–specific IgE and age are not good predictors of passing a baked egg challenge. However, there was a trend for more predictability with SPT wheal size. PMID:22584194

Development of Antipsychotic Medications with Novel Mechanisms of Action Based on Computational Modeling of Hippocampal Neuropathology

PubMed Central

Siekmeier, Peter J.; vanMaanen, David P.

2013-01-01

A large number of cellular level abnormalities have been identified in the hippocampus of schizophrenic subjects. Nonetheless, it remains uncertain how these pathologies interact at a system level to create clinical symptoms, and this has hindered the development of more effective antipsychotic medications. Using a 72-processor supercomputer, we created a tissue level hippocampal simulation, featuring multicompartmental neuron models with multiple ion channel subtypes and synaptic channels with realistic temporal dynamics. As an index of the schizophrenic phenotype, we used the specific inability of the model to attune to 40 Hz (gamma band) stimulation, a well-characterized abnormality in schizophrenia. We examined several possible combinations of putatively schizophrenogenic cellular lesions by systematically varying model parameters representing NMDA channel function, dendritic spine density, and GABA system integrity, conducting 910 trials in total. Two discrete “clusters” of neuropathological changes were identified. The most robust was characterized by co-occurring modest reductions in NMDA system function (-30%) and dendritic spine density (-30%). Another set of lesions had greater NMDA hypofunction along with low level GABA system dysregulation. To the schizophrenic model, we applied the effects of 1,500 virtual medications, which were implemented by varying five model parameters, independently, in a graded manner; the effects of known drugs were also applied. The simulation accurately distinguished agents that are known to lack clinical efficacy, and identified novel mechanisms (e.g., decrease in AMPA conductance decay time constant, increase in projection strength of calretinin-positive interneurons) and combinations of mechanisms that could re-equilibrate model behavior. These findings shed light on the mechanistic links between schizophrenic neuropathology and the gamma band oscillatory abnormalities observed in the illness. As such, they generate specific falsifiable hypotheses, which can guide postmortem and other laboratory research. Significantly, this work also suggests specific non-obvious targets for potential pharmacologic agents. PMID:23526999

Determination of specific yield and water-table changes using temporal microgravity surveys collected during the second injection, storage, and recovery test at Lancaster, Antelope Valley, California, November 1996 through April 1997

USGS Publications Warehouse

Howle, James F.; Phillips, Steven P.; Denlinger, Roger P.; Metzger, Loren F.

2003-01-01

To evaluate the feasibility of artificially recharging the ground-water system in the Lancaster area of the Antelope Valley, California, the U.S. Geological Survey, in cooperation with the Los Angeles County Department of Public Works and the Antelope Valley-East Kern Water Agency, conducted a series of injection, storage, and recovery tests between September 1995 and September 1998. A key component of this study was to measure the response of the water table to injection, which was difficult because the water table averaged 300 feet below land surface. Rather than install many expensive piezometers, microgravity surveys were conducted to determine specific yield and to measure the development of a ground-water mound during the injection of about 1,050 acre-feet of fresh water into an alluvial-aquifer system. The surveys were done prior to, during, and near the end of a 5-month injection period (November 12, 1996, to April 17, 1997). Results of the surveys indicate increases in gravity of as much as 66 microgals between a bedrock reference station and 20 gravity stations within a 1-square-mile area surrounding the injection site. The changes were assumed to have been caused by changes in the ground-water elevation. Gravity and ground-water levels were measured simultaneously at an existing well (7N/12W-34B1). The coupled measurements were used to calculate a specific yield of 0.13 for the alluvial aquifer near the well. To determine the gravitational effect of the injection mound on the gravity measurements made near well 7N/12W-34B1, a two-dimensional gravity model was used. Results of the model simulation show that the effect on gravity associated with the mass of the injection mound was minor and thus had a negligible effect on the calculation of specific yield. The specific yield of 0.13, therefore, was used to infer water-level changes at other gravity stations within the study area. The gravity-derived water-level changes were compared with simulated water-table changes.

Moderating effects of media exposure on associations between socioeconomic position and cancer worry.

PubMed

Jung, Minsoo; Chan, Carina Ka Yee; Viswanath, Kasisomayajula

2014-01-01

Reducing fear of cancer is significant in developing cancer screening interventions, but the levels of fear may vary depending on the degrees of media exposure as well as individuals' socioeconomic positions (SEP). However, few studies have examined how the SEP influences the fear of cancer under the moderating process of general and specific forms of media exposure. We investigated the moderating effect of media exposure on the relationship between SEP and the level of fear of cancer by assuming that cancer knowledge is a covariate between those two. In particular, this study examined how exposure to both general and specific media changes the series of processes from SEP to fear of cancer. We conducted path analyses with three types of media--television, radio and the Internet--using data from a health communication survey of 613 adults in Massachusetts in the United States. We found that SEP influences cancer knowledge directly and fear of cancer indirectly, as moderated by the level of media exposure. Health-specific exposure, however, had a more consistent effect than general media exposure in lowering the fear of cancer by increasing knowledge about cancer. A higher level of health-specific exposure and greater amount of cancer knowledge lessened the fear of cancer. In addition, the more people were exposed to health information on television and the Internet, the lower the level of fear of cancer as a result. These findings indicate a relationship between SEP and fear of cancer, as moderated by the level and type of media exposure. Furthermore, the findings suggest that for early detection or cancer prevention strategies, health communication approaches through mass media need to be considered.

What environmental factors influence resumption of valued activities post stroke: a systematic review of qualitative and quantitative findings.

PubMed

Jellema, Sandra; van Hees, Suzanne; Zajec, Jana; van der Sande, Rob; Nijhuis-van der Sanden, Maria Wg; Steultjens, Esther Mj

2017-07-01

Identify the environmental factors that influence stroke-survivors' reengagement in personally valued activities and determine what specific environmental factors are related to specific valued activity types. PubMed, CINAHL and PsycINFO were searched until June 2016 using multiple search-terms for stroke, activities, disability, and home and community environments. An integrated mixed-method systematic review of qualitative, quantitative and mixed-design studies was conducted. Two researchers independently identified relevant studies, assessed their methodological quality and extracted relevant findings. To validly compare and combine the various findings, all findings were classified and grouped by environmental category and level of evidence. The search yielded 4024 records; 69 studies were included. Most findings came from low-evidence-level studies such as single qualitative studies. All findings were consistent in that the following factors facilitated reengagement post-stroke: personal adapted equipment; accessible environments; transport; services; education and information. Barriers were: others' negative attitudes and behaviour; long distances and inconvenient environmental conditions (such as bad weather). Each type of valued activity, such as mobility or work, had its own pattern of environmental influences, social support was a facilitator to all types of activities. Although in many qualitative studies others' attitudes, behaviour and stroke-related knowledge were seen as important for reengagement, these factors were hardly studied quantitatively. A diversity of environmental factors was related to stroke-survivors' reengagement. Most findings came from low-evidence-level studies so that evidence on causal relationships was scarce. In future, more higher-level-evidence studies, for example on the attitudes of significant others, should be conducted.

General Framework for Meta-analysis of Rare Variants in Sequencing Association Studies

PubMed Central

Lee, Seunggeun; Teslovich, Tanya M.; Boehnke, Michael; Lin, Xihong

2013-01-01

We propose a general statistical framework for meta-analysis of gene- or region-based multimarker rare variant association tests in sequencing association studies. In genome-wide association studies, single-marker meta-analysis has been widely used to increase statistical power by combining results via regression coefficients and standard errors from different studies. In analysis of rare variants in sequencing studies, region-based multimarker tests are often used to increase power. We propose meta-analysis methods for commonly used gene- or region-based rare variants tests, such as burden tests and variance component tests. Because estimation of regression coefficients of individual rare variants is often unstable or not feasible, the proposed method avoids this difficulty by calculating score statistics instead that only require fitting the null model for each study and then aggregating these score statistics across studies. Our proposed meta-analysis rare variant association tests are conducted based on study-specific summary statistics, specifically score statistics for each variant and between-variant covariance-type (linkage disequilibrium) relationship statistics for each gene or region. The proposed methods are able to incorporate different levels of heterogeneity of genetic effects across studies and are applicable to meta-analysis of multiple ancestry groups. We show that the proposed methods are essentially as powerful as joint analysis by directly pooling individual level genotype data. We conduct extensive simulations to evaluate the performance of our methods by varying levels of heterogeneity across studies, and we apply the proposed methods to meta-analysis of rare variant effects in a multicohort study of the genetics of blood lipid levels. PMID:23768515

Group-Specific Effects of Matching Subtest Contamination on the Identification of Differential Item Functioning

ERIC Educational Resources Information Center

Keiffer, Elizabeth Ann

2011-01-01

A differential item functioning (DIF) simulation study was conducted to explore the type and level of impact that contamination had on type I error and power rates in DIF analyses when the suspect item favored the same or opposite group as the DIF items in the matching subtest. Type I error and power rates were displayed separately for the…

Evolution of Languages for Specific Purposes Programs in the United States: 1990-2011

ERIC Educational Resources Information Center

Long, Mary K.; Uscinski, Izabela

2012-01-01

This article reports the results of a national survey of LSP offerings in U.S. higher education conducted during 2011. The survey updates one carried out by Christine Uber-Grosse and Geoffrey M. Voght in 1990. The data provide: (a) a profile of institutions that offer LSP; (b) an overview of the number, type, level, and enrollment in LSP courses;…

Specific Needs for Updating Educational Experiences as Reported by Instructors of Electronics in Industrial Education Departments of Colleges and Universities.

ERIC Educational Resources Information Center

Slater, John Breisch

A survey of 133 industrial education electronics instructors in 115 4-year colleges and universities in 40 states was conducted to determine the expressed needs of college level electronics instructors for updating educational experiences in specified elements. An attempt was also made to determine the nature of course content needed in graduate…

Investigating Variation in Teaching with Technology-Rich Intervention: What Matters in Teaching and Teacher Training at Scale?

ERIC Educational Resources Information Center

Dunn, Margaret Breslin

2009-01-01

A main question this dissertation addresses is: what variation in teaching and teacher training matter? This question is examined within a specific but important context: the scale-up of a technology-rich intervention focused on the algebra strand of 8th grade mathematics. I conducted a multi-level case study by gathering and analyzing data at…

It is time to combine the two main traditions in the research on the neural correlates of consciousness: C = L × D

PubMed Central

Bachmann, Talis; Hudetz, Anthony G.

2014-01-01

Research on neural correlates of consciousness has been conducted and carried out mostly from within two relatively autonomous paradigmatic traditions – studying the specific contents of conscious experience and their brain-process correlates and studying the level of consciousness. In the present paper we offer a theoretical integration suggesting that an emphasis has to be put on understanding the mechanisms of consciousness (and not a mere correlates) and in doing this, the two paradigmatic traditions must be combined. We argue that consciousness emerges as a result of interaction of brain mechanisms specialized for representing the specific contents of perception/cognition – the data – and mechanisms specialized for regulating the level of activity of whatever data the content-carrying specific mechanisms happen to represent. Each of these mechanisms are necessary because without the contents there is no conscious experience and without the required level of activity the processed contents remain unconscious. Together the two mechanisms, when activated up to a necessary degree each, provide conditions sufficient for conscious experience to emerge. This proposal is related to pertinent experimental evidence. PMID:25202297

Effects of aircraft cabin noise on passenger comfort.

PubMed

Pennig, Sibylle; Quehl, Julia; Rolny, Vinzent

2012-01-01

The effects of cabin noise on subjective comfort assessments were systematically investigated in order to reveal optimisation potentials for an improved passenger noise acceptance. Two aircraft simulation studies were conducted. An acoustic laboratory test facility provided with loudspeaker systems for realistic sound presentations and an aircraft cabin simulator (Dornier Do 728) with a high degree of ecological validity were used. Subjects were exposed to nine different noise patterns (three noise levels ranging from 66 to 78 dB(A) combined with three different frequency spectra). Regression analysis demonstrated a significant increase of passengers' acceptance with lower noise levels and significant effects of different frequency spectra determined by seat position in the aircraft cabin (front, middle, rear). Acoustic cabin design should therefore consider measures beyond noise level reduction altering noise characteristics to improve passengers' comfort and well-being in the aircraft cabin. To improve passenger comfort in the aircraft with respect to cabin noise, passengers' reactions to specific noise conditions were systematically investigated. Two laboratory studies showed significant dose-response relationships between sound pressure level and subjective comfort ratings which differed due to the noise at specific seat positions in the aircraft.

Using SAS PROC CALIS to fit Level-1 error covariance structures of latent growth models.

PubMed

Ding, Cherng G; Jane, Ten-Der

2012-09-01

In the present article, we demonstrates the use of SAS PROC CALIS to fit various types of Level-1 error covariance structures of latent growth models (LGM). Advantages of the SEM approach, on which PROC CALIS is based, include the capabilities of modeling the change over time for latent constructs, measured by multiple indicators; embedding LGM into a larger latent variable model; incorporating measurement models for latent predictors; and better assessing model fit and the flexibility in specifying error covariance structures. The strength of PROC CALIS is always accompanied with technical coding work, which needs to be specifically addressed. We provide a tutorial on the SAS syntax for modeling the growth of a manifest variable and the growth of a latent construct, focusing the documentation on the specification of Level-1 error covariance structures. Illustrations are conducted with the data generated from two given latent growth models. The coding provided is helpful when the growth model has been well determined and the Level-1 error covariance structure is to be identified.

Gender variations in waist circumference levels between Aboriginal and non-Aboriginal Australian populations: a systematic review.

PubMed

Adegbija, Odewumi Oluwarotimi; Wang, Zhiqiang

2014-01-01

To compare gender-specific waist circumference (WC) levels of Aboriginal Australians with non-Aboriginal Australians. A systematic search on Medline, PubMed, EMBASE and Google Scholar databases was conducted to identify papers that reported gender-specific waist circumference (WC) estimates of participants from the age of 15 years and above among Aboriginal and non-Aboriginal Australians. Means and their 95% confidence intervals of gender differences in WC, height and weight were recorded or calculated where they were not provided. Gender-specific WC, height and weight mean estimates were pooled and the I(2) statistic was used to test heterogeneity among Aboriginal and non-Aboriginal Australians. Of 17 selected cross-sectional studies, 9 focused on Aboriginal and 8 on non-Aboriginal Australians. Seven studies reported significantly higher WC estimates among indigenous females than males. On the other hand, non-indigenous males had significantly higher WC levels than females. Males had greater height and weight estimates than females in both groups. Although indigenous women were shorter and had lower weight estimates, they had greater WC levels than indigenous men. This is the first systematic review to assess the gender-specific differences between Aboriginal and non-Aboriginal Australians. The findings of this review warrant more efforts to understand and reduce the high prevalence of central obesity and related chronic diseases among Aboriginal women. Copyright © 2014 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

Heat, chloride, and specific conductance as ground water tracers near streams

USGS Publications Warehouse

Cox, M.H.; Su, G.W.; Constantz, J.

2007-01-01

Commonly measured water quality parameters were compared to heat as tracers of stream water exchange with ground water. Temperature, specific conductance, and chloride were sampled at various frequencies in the stream and adjacent wells over a 2-year period. Strong seasonal variations in stream water were observed for temperature and specific conductance. In observation wells where the temperature response correlated to stream water, chloride and specific conductance values were similar to stream water values as well, indicating significant stream water exchange with ground water. At sites where ground water temperature fluctuations were negligible, chloride and/or specific conductance values did not correlate to stream water values, indicating that ground water was not significantly influenced by exchange with stream water. Best-fit simulation modeling was performed at two sites to derive temperature-based estimates of hydraulic conductivities of the alluvial sediments between the stream and wells. These estimates were used in solute transport simulations for a comparison of measured and simulated values for chloride and specific conductance. Simulation results showed that hydraulic conductivities vary seasonally and annually. This variability was a result of seasonal changes in temperature-dependent hydraulic conductivity and scouring or clogging of the streambed. Specific conductance fits were good, while chloride data were difficult to fit due to the infrequent (quarterly) stream water chloride measurements during the study period. Combined analyses of temperature, chloride, and specific conductance led to improved quantification of the spatial and temporal variability of stream water exchange with shallow ground water in an alluvial system. ?? 2007 National Ground Water Association.

State firearm laws, firearm ownership, and safety practices among families of preschool-aged children.

PubMed

Prickett, Kate C; Martin-Storey, Alexa; Crosnoe, Robert

2014-06-01

We investigated how state-level firearms legislation is associated with firearm ownership and storage among families with preschool-aged children. Using 2005 nationally representative data from the Early Childhood Longitudinal Study-Birth Cohort (n = 8100), we conducted multinomial regression models to examine the associations between state-level firearms legislation generally, child access prevention (CAP) firearms legislation specifically, and parental firearm ownership and storage safety practices. Overall, 8% of families with children aged 4 years living in states with stronger firearm laws and CAP laws owned firearms compared with 24% of families in states with weaker firearm laws and no CAP laws. Storage behaviors of firearm owners differed minimally across legislative contexts. When we controlled for family- and state-level characteristics, we found that firearm legislation and CAP laws interacted to predict ownership and storage behaviors, with unsafe storage least likely among families in states with both CAP laws and stronger firearm legislation. Broader firearm legislation is linked with the efficacy of child-specific legislation in promoting responsible firearm ownership.

Partnership-Level Analysis of African American Women's Risky Sexual Behavior in Main and Non-Main Partnerships.

PubMed

Broaddus, Michelle; Owczarzak, Jill; Pacella, Maria; Pinkerton, Steven; Wright, Cassandra

2016-12-01

The majority of research on risky sexual behavior in African American women has examined global associations between individual-level predictors and behavior. However, this method obscures the potentially significant impact of the specific relationship or relationship partner on risky sexual behavior. To address this gap, we conducted partnership-level analysis of risky sexual behavior among 718 African American women recruited from HIV counseling, testing, and referral sites in four states. Using mixed model regressions, we tested relationships between condomless vaginal intercourse with men and variables drawn from the Theory of Planned Behavior, Theory of Gender and Power, and previous research specifically on sexual risks among African American women. Significant associations with risky sexual behavior indicate the need for continued emphasis on condom attitudes, condom negotiation behaviors, and overcoming partner resistance to condoms within both main and non-main partnerships when implementing interventions designed to address HIV and sexually transmitted infection risks among African American women.

Performance management in healthcare: a critical analysis.

PubMed

Hewko, Sarah J; Cummings, Greta G

2016-01-01

Purpose - The purpose of this paper is to explore the underlying theoretical assumptions and implications of current micro-level performance management and evaluation (PME) practices, specifically within health-care organizations. PME encompasses all activities that are designed and conducted to align employee outputs with organizational goals. Design/methodology/approach - PME, in the context of healthcare, is analyzed through the lens of critical theory. Specifically, Habermas' theory of communicative action is used to highlight some of the questions that arise in looking critically at PME. To provide a richer definition of key theoretical concepts, the authors conducted a preliminary, exploratory hermeneutic semantic analysis of the key words "performance" and "management" and of the term "performance management". Findings - Analysis reveals that existing micro-level PME systems in health-care organizations have the potential to create a workforce that is compliant, dependent, technically oriented and passive, and to support health-care systems in which inequalities and power imbalances are perpetually reinforced. Practical implications - At a time when the health-care system is under increasing pressure to provide high-quality, affordable services with fewer resources, it may be wise to investigate new sector-specific ways of evaluating and managing performance. Originality/value - In this paper, written for health-care leaders and health human resource specialists, the theoretical assumptions and implications of current PME practices within health-care organizations are explored. It is hoped that readers will be inspired to support innovative PME practices within their organizations that encourage peak performance among health-care professionals.

A Novel Computer-Aided Approach for Parametric Investigation of Custom Design of Fracture Fixation Plates.

PubMed

Chen, Xiaozhong; He, Kunjin; Chen, Zhengming

2017-01-01

The present study proposes an integrated computer-aided approach combining femur surface modeling, fracture evidence recover plate creation, and plate modification in order to conduct a parametric investigation of the design of custom plate for a specific patient. The study allows for improving the design efficiency of specific plates on the patients' femur parameters and the fracture information. Furthermore, the present approach will lead to exploration of plate modification and optimization. The three-dimensional (3D) surface model of a detailed femur and the corresponding fixation plate were represented with high-level feature parameters, and the shape of the specific plate was recursively modified in order to obtain the optimal plate for a specific patient. The proposed approach was tested and verified on a case study, and it could be helpful for orthopedic surgeons to design and modify the plate in order to fit the specific femur anatomy and the fracture information.

Myofibroblasts Electrotonically Coupled to Cardiomyocytes Alter Conduction: Insights at the Cellular Level from a Detailed In silico Tissue Structure Model

PubMed Central

Jousset, Florian; Maguy, Ange; Rohr, Stephan; Kucera, Jan P.

2016-01-01

Fibrotic myocardial remodeling is typically accompanied by the appearance of myofibroblasts (MFBs). In vitro, MFBs were shown to slow conduction and precipitate ectopic activity following gap junctional coupling to cardiomyocytes (CMCs). To gain further mechanistic insights into this arrhythmogenic MFB-CMC crosstalk, we performed numerical simulations in cell-based high-resolution two-dimensional tissue models that replicated experimental conditions. Cell dimensions were determined using confocal microscopy of single and co-cultured neonatal rat ventricular CMCs and MFBs. Conduction was investigated as a function of MFB density in three distinct cellular tissue architectures: CMC strands with endogenous MFBs, CMC strands with coating MFBs of two different sizes, and CMC strands with MFB inserts. Simulations were performed to identify individual contributions of heterocellular gap junctional coupling and of the specific electrical phenotype of MFBs. With increasing MFB density, both endogenous and coating MFBs slowed conduction. At MFB densities of 5–30%, conduction slowing was most pronounced in strands with endogenous MFBs due to the MFB-dependent increase in axial resistance. At MFB densities >40%, very slow conduction and spontaneous activity was primarily due to MFB-induced CMC depolarization. Coating MFBs caused non-uniformities of resting membrane potential, which were more prominent with large than with small MFBs. In simulations of MFB inserts connecting two CMC strands, conduction delays increased with increasing insert lengths and block appeared for inserts >1.2 mm. Thus, electrophysiological properties of engineered CMC-MFB co-cultures depend on MFB density, MFB size and their specific positioning in respect to CMCs. These factors may influence conduction characteristics in the heterocellular myocardium. PMID:27833567

7 CFR 1484.34 - Must Cooperators adhere to specific standards of ethical conduct?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Must Cooperators adhere to specific standards of ethical conduct? 1484.34 Section 1484.34 Agriculture Regulations of the Department of Agriculture... Cooperators adhere to specific standards of ethical conduct? (a) A Cooperator shall conduct its business in...

7 CFR 1484.34 - Must Cooperators adhere to specific standards of ethical conduct?

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 10 2014-01-01 2014-01-01 false Must Cooperators adhere to specific standards of ethical conduct? 1484.34 Section 1484.34 Agriculture Regulations of the Department of Agriculture... specific standards of ethical conduct? (a) A Cooperator shall conduct its business in accordance with the...

7 CFR 1484.34 - Must Cooperators adhere to specific standards of ethical conduct?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 10 2013-01-01 2013-01-01 false Must Cooperators adhere to specific standards of ethical conduct? 1484.34 Section 1484.34 Agriculture Regulations of the Department of Agriculture... specific standards of ethical conduct? (a) A Cooperator shall conduct its business in accordance with the...

7 CFR 1484.34 - Must Cooperators adhere to specific standards of ethical conduct?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 10 2012-01-01 2012-01-01 false Must Cooperators adhere to specific standards of ethical conduct? 1484.34 Section 1484.34 Agriculture Regulations of the Department of Agriculture... specific standards of ethical conduct? (a) A Cooperator shall conduct its business in accordance with the...

Laboratory Biomarkers to Facilitate Differential Diagnosis between Measles and Kawasaki Disease in a Pediatric Emergency Room: A Retrospective Study.

PubMed

Buonsenso, Danilo; Macchiarulo, Giulia; Supino, Maria Chiara; La Penna, Francesco; Scateni, Simona; Marchesi, Alessandra; Reale, Antonino; Boccuzzi, Elena

2018-01-01

This retrospective study was conducted to analyze clinical and laboratoristic parameters to individuate specific differences and facilitate differential diagnosis between Measles and Kawasaki Disease (KD) at first evaluation in an emergency room. We found similar clinical features as duration of fever and number of KD criteria (p > 0.5) but significant differences in white blood cell count, neutrophils, CRP and LDH levels (p < 0.001). LDH value ≥ 800 mg/dl had sensibility of 89% and specificity of 90% for Measles while CRP ≥ 3 mg/dl had sensibility 89% and specificity of 85% for KD. The combined use of CRP, LDH and AST showed accuracy of 86.67%.

Review of teaching methods and critical thinking skills.

PubMed

Kowalczyk, Nina

2011-01-01

Critical information is needed to inform radiation science educators regarding successful critical thinking educational strategies. From an evidence-based research perspective, systematic reviews are identified as the most current and highest level of evidence. Analysis at this high level is crucial in analyzing those teaching methods most appropriate to the development of critical thinking skills. To conduct a systematic literature review to identify teaching methods that demonstrate a positive effect on the development of students' critical thinking skills and to identify how these teaching strategies can best translate to radiologic science educational programs. A comprehensive literature search was conducted resulting in an assessment of 59 full reports. Nineteen of the 59 reports met inclusion criteria and were reviewed based on the level of evidence presented. Inclusion criteria included studies conducted in the past 10 years on sample sizes of 20 or more individuals demonstrating use of specific teaching interventions for 5 to 36 months in postsecondary health-related educational programs. The majority of the research focused on problem-based learning (PBL) requiring standardized small-group activities. Six of the 19 studies focused on PBL and demonstrated significant differences in student critical thinking scores. PBL, as described in the nursing literature, is an effective teaching method that should be used in radiation science education. ©2011 by the American Society of Radiologic Technologists.

Chemical sensing employingpH sensitive emeraldine base thin film for carbon dioxide detection

NASA Astrophysics Data System (ADS)

Irimia-Vladu, Mihai

Respiration, or CO2 evolution, is a universal indicator for all the biological activities. Among many potential applications, the measurement of CO2 evolution has been found to be a rapid and nondestructive means for examining microbial contamination of food. The sensor developed in this work consists of a thin emeraldine base-polyaniline (EB-PAni) film. In the first half of the project the effect of carbon dioxide over the conductivity of a composite film of emeraldine base polyaniline and poly(vinyl alcohol) in N-methyl pyrrolidone (NMP) respectively was tested. Argon gas or mixture of argon and 5% CO2 were circulated through the glass cell containing the polymer film deposited on interdigitated electrode and exposed to specific humidity levels fixed by aqueous supersaturated salt solutions. In the second half of the project, a thin emeraldine base film in NMP was directly deposited on interdigitated electrode and the respective sensor inserted in water. Carbonic acid solutions of various pHs were generated by bubbling specific mixtures of carbon dioxide and argon. Conductivity measurements were performed by impedance spectroscopy throughout the project. The sensing mechanism is based on intermediate stages of the transformation of the emeraldine base polyaniline to a conductive salt type (ES-PAni). This EB-ES transformation is the consequence of the exposure of EB-PAni to a protonic acid and is accompanied by a change in the conductivity of the polymer film. Carbonic acid, unfortunately, is a very weak acid and is unable to induce a conductivity change, but the intermediate steps that predetermine this transformation are detected by impedance spectroscopy even when the overall conductivity of the film is unchanged. The composite thin film developed in the first part of the project showed poor sensing characteristics: limited dynamic range, drift, instability and slow time response. However, the sensor design employed in the second half of this work, coupled with impedance spectroscopy measurements, revealed valuable information about conduction mechanisms at pH levels were the overall conductivity of the film remained unchanged. Typical impedance spectra for the emeraldine thin films for a frequency sweep between 3.2 E7 to 1 Hz shows a single semicircle. The overall conductivity of the film (5x10-4 S/cm) does not change when CO 2 is bubbled through the water in which the sensor is immersed, but an additional semicircle starts to appear at low (less than 200 Hz) frequency corresponding to lowering the pH of the solution below 5.0. The original semicircle diminishes in size but maintains its initial peak frequency. The EB film is very sensitive to pH changes, therefore an additional semicircle appears in unpurified argon gas due to the reduction of the pH of water solution to 4.65. The same mechanism is displayed in hydrochloric acid solutions of various pH. The formation of the second semicircle depends on the initial conductivity of the emeraldine base film, a film displaying an initial conductivity of 4.8 x 10-3 S/cm forming the second semicircle at a pH of 5.85. The appearance of the second semicircle is most likely due to a preferential protonation in the insulating matrix of the polymer film. The overall conductivity of the film increases when the level of protonation in the insulating portion of the film reached a level close to the protonation level in the scattered metallic islands, allowing the electron-hopping mechanism to became active. The sensor output is stable and reproducible even after 11 months passed from the polymer film deposition.

Appendix 3 Summary of Field Sampling and Analytical Methods with Bibliography

EPA Science Inventory

Conductivity and Specific conductance are measures of the ability of water to conduct an electric current, and are a general measure of stream-water quality. Conductivity is affected by temperature, with warmer water having a greater conductivity. Specific conductance is the te...

Analysis of Subjects' Vulnerability in a Touch Screen Game Using Behavioral Metrics.

PubMed

Parsinejad, Payam; Sipahi, Rifat

2017-12-01

In this article, we report results on an experimental study conducted with volunteer subjects playing a touch-screen game with two unique difficulty levels. Subjects have knowledge about the rules of both game levels, but only sufficient playing experience with the easy level of the game, making them vulnerable with the difficult level. Several behavioral metrics associated with subjects' playing the game are studied in order to assess subjects' mental-workload changes induced by their vulnerability. Specifically, these metrics are calculated based on subjects' finger kinematics and decision making times, which are then compared with baseline metrics, namely, performance metrics pertaining to how well the game is played and a physiological metric called pnn50 extracted from heart rate measurements. In balanced experiments and supported by comparisons with baseline metrics, it is found that some of the studied behavioral metrics have the potential to be used to infer subjects' mental workload changes through different levels of the game. These metrics, which are decoupled from task specifics, relate to subjects' ability to develop strategies to play the game, and hence have the advantage of offering insight into subjects' task-load and vulnerability assessment across various experimental settings.

Epigenetic regulation of the DRD4 gene and dimensions of attention-deficit/hyperactivity disorder in children.

PubMed

Dadds, Mark R; Schollar-Root, Olivia; Lenroot, Rhoshel; Moul, Caroline; Hawes, David J

2016-10-01

Recent evidence suggests that epigenetic regulation of the DRD4 gene may characterise specific aspects of ADHD symptomology. We tested associations between ADHD symptoms and epigenetic changes to the DRD4 gene in DNA extracted from blood and saliva in N = 330 children referred for a variety of behavioural and emotional problems. ADHD was indexed using DSM diagnoses as well as mother, father, and teacher reports. Methylation levels were assayed for the island of 18 CpG sites in the DRD4 receptor gene. A nearby SNP, rs3758653, was also genotyped as it has previously been shown to influence methylation levels. There was high consistency of methylation levels across CpG sites and tissue sources, and higher methylation levels were associated with the major allele of SNP rs3758653. Higher methylation levels were associated with more severe ADHD independent of SNP status, tissue source, ethnicity, environmental adversity, and comorbid conduct problems. The association applied specifically to the cognitive/attentional, rather than hyperactivity problems that characterise ADHD. The results indicate that epigenetic regulation of the DRD4 gene in the form of increased methylation is associated with the cognitive/attentional deficits in ADHD.

Meta-QTL analysis of seed iron and zinc concentration and content in common bean (Phaseolus vulgaris L.).

PubMed

Izquierdo, Paulo; Astudillo, Carolina; Blair, Matthew W; Iqbal, Asif M; Raatz, Bodo; Cichy, Karen A

2018-05-11

Twelve meta-QTL for seed Fe and Zn concentration and/or content were identified from 87 QTL originating from seven population grown in sixteen field trials. These meta-QTL include 2 specific to iron, 2 specific to zinc and 8 that co-localize for iron and zinc concentrations and/or content. Common bean (Phaseolus vulgaris L.) is the most important legume for human consumption worldwide and it is an important source of microelements, especially iron and zinc. Bean biofortification breeding programs develop new varieties with high levels of Fe and Zn targeted for countries with human micronutrient deficiencies. Biofortification efforts thus far have relied on phenotypic selection of raw seed mineral concentrations in advanced generations. While numerous quantitative trait loci (QTL) studies have been conducted to identify genomic regions associated with increased Fe and Zn concentration in seeds, these results have yet to be employed for marker-assisted breeding. The objective of this study was to conduct a meta-analysis from seven QTL studies in Andean and Middle American intra- and inter-gene pool populations to identify the regions in the genome that control the Fe and Zn levels in seeds. Two meta-QTL specific to Fe and two meta-QTL specific to Zn were identified. Additionally, eight Meta QTL that co-localized for Fe and Zn concentration and/or content were identified across seven chromosomes. The Fe and Zn shared meta-QTL could be useful candidates for marker-assisted breeding to simultaneously increase seed Fe and Zn. The physical positions for 12 individual meta-QTL were identified and within five of the meta-QTL, candidate genes were identified from six gene families that have been associated with transport of iron and zinc in plants.

Neighborhood-Level Correlates of Consistent Condom Use among Men Who have Sex with Men: A Multi-Level Analysis

PubMed Central

Koblin, Beryl; Chin, John; Beard, John; Blaney, Shannon; Halkitis, Perry; Vlahov, David; Galea, Sandro

2014-01-01

There is growing evidence that the neighborhood environment influences sexual behavior and related outcomes, but little work has focused specifically on men who have sex with men (MSM). Using interview data from a probability sample of 385 young MSM living in New York City, recruited at public venues in 1999 and 2000 as part of the Young Men’s Survey-New York City, and data on neighborhood characteristics obtained from the U.S. Census 2000, we conducted multi-level analyses of the associations between neighborhood-level characteristics and consistent condom use during anal intercourse, while controlling for individual-level sociodemographic and other factors. After adjusting for individual-level factors, neighborhood-level gay presence remained significantly and positively associated with consistent condom use during anal intercourse. This finding suggests that neighborhoods with a significant gay presence may have norms that act to discourage high risk sexual activity. PMID:18712593

NASA Glenn's Acoustical Testing Laboratory Awarded Accreditation by the National Voluntary Laboratory Accreditation Program

NASA Technical Reports Server (NTRS)

Akers, James C.; Cooper, Beth A.

2004-01-01

NASA Glenn Research Center's Acoustical Testing Laboratory (ATL) provides a comprehensive array of acoustical testing services, including sound pressure level, sound intensity level, and sound-power-level testing per International Standards Organization (ISO)1 3744. Since its establishment in September 2000, the ATL has provided acoustic emission testing and noise control services for a variety of customers, particularly microgravity space flight hardware that must meet International Space Station acoustic emission requirements. The ATL consists of a 23- by 27- by 20-ft (height) convertible hemi/anechoic test chamber and a separate sound-attenuating test support enclosure. The ATL employs a personal-computer-based data acquisition system that provides up to 26 channels of simultaneous data acquisition with real-time analysis (ref. 4). Specialized diagnostic tools, including a scanning sound-intensity system, allow the ATL's technical staff to support its clients' aggressive low-noise design efforts to meet the space station's acoustic emission requirement. From its inception, the ATL has pursued the goal of developing a comprehensive ISO 17025-compliant quality program that would incorporate Glenn's existing ISO 9000 quality system policies as well as ATL-specific technical policies and procedures. In March 2003, the ATL quality program was awarded accreditation by the National Voluntary Laboratory Accreditation Program (NVLAP) for sound-power-level testing in accordance with ISO 3744. The NVLAP program is administered by the National Institutes of Standards and Technology (NIST) of the U.S. Department of Commerce and provides third-party accreditation for testing and calibration laboratories. There are currently 24 NVLAP-accredited acoustical testing laboratories in the United States. NVLAP accreditation covering one or more specific testing procedures conducted in accordance with established test standards is awarded upon successful completion of an intensive onsite assessment that includes proficiency testing and documentation review. The ATL NVLAP accreditation currently applies specifically to its ISO 3744 soundpower- level determination procedure (see the photograph) and supporting ISO 17025 quality system, although all ATL operations are conducted in accordance with its quality system. The ATL staff is currently developing additional procedures to adapt this quality system to the testing of space flight hardware in accordance with International Space Station acoustic emission requirements.<

Effect of humidity on fretting wear of several pure metals

NASA Technical Reports Server (NTRS)

Goto, H.; Buckley, D. H.

1984-01-01

Fretting wear experiments with several pure metals were conducted in air at various relative humidity levels. The materials used were iron, aluminum, copper, silver, chromium, titanium, and nickel. Each pure metal had a maximum fretting wear volume at a specific humidity level RH sub max that was not dependent on mechanical factors such as contact load, fretting amplitude, and frequency in the ranges studied. The weight loss due to fretting wear at RH sub max for each pure metal decreased with increasing heat of oxygen adsorption on the metal, indicating that adhesive wear dominated at RH sub max.

The trade-off between safety and efficiency in hydraulic architecture in 31 woody species in a karst area.

PubMed

Fan, Da-Yong; Jie, Sheng-Lin; Liu, Chang-Cheng; Zhang, Xiang-Ying; Xu, Xin-Wu; Zhang, Shou-Ren; Xie, Zong-Qiang

2011-08-01

Karst topography is a special landscape shaped by the dissolution of one or more layers of soluble bedrock, usually carbonate rock such as limestone or dolomite. Due to subterranean drainage, overland flow, extraction of water by plants and evapotranspiration, there may be very limited surface water. The hydraulic architecture that plants use to adapt to karst topography is very interesting, but few systematic reports exist. The karst area in southwestern China is unique when compared with other karst areas at similar latitudes, because of its abundant precipitation, with rainfall concentrated in the growing season. In theory, resistance to water-stress-induced cavitation via air seeding should be accompanied by decreased pore hydraulic conductivity and stem hydraulic conductivity. However, evidence for such trade-offs across species is ambiguous. We measured the hydraulic structure and foliar stable carbon isotope ratios of 31 karst woody plants at three locations in Guizhou Province, China, to evaluate the functional coordination between resistance to cavitation and specific conductivity. We also applied phylogenetically independent contrast (PIC) analysis in situations where the inter-species correlations of functional traits may be biased on the potential similarity of closely related species. The average xylem tension measurement, at which 50% of hydraulic conductivity of the plants was lost (Ψ(50)), was only -1.27 MPa. Stem Ψ(50) was positively associated with specific conductance (K(s)) (P < 0.05) and leaf specific conductance (K(l)) (P < 0.05). However, the PIC correlation for both relationships was not statistically significant. δ(13)C was positively related to K(l) in both the traditional cross-species correlation analysis and the corresponding PIC correlations (P < 0.05). The Huber value (sapwood area:leaf area ratio) was negatively correlated with K(s) in both the traditional cross-species correlation and the corresponding PIC correlations (P < 0.01). The characteristics of hydraulic architecture measured in this study showed that karst plants in China are not highly cavitation-resistant species. This study also supports the idea that there may not be an evolutionary trade-off between resistance to cavitation and specific conductivity in woody plants. Whole-plant hydraulic adjustment may decouple the trade-off relationship between safety and efficiency at the branch level.

Measurement uncertainty for the Uniform Engine Testing Program conducted at NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Abdelwahab, Mahmood; Biesiadny, Thomas J.; Silver, Dean

1987-01-01

An uncertainty analysis was conducted to determine the bias and precision errors and total uncertainty of measured turbojet engine performance parameters. The engine tests were conducted as part of the Uniform Engine Test Program which was sponsored by the Advisory Group for Aerospace Research and Development (AGARD). With the same engines, support hardware, and instrumentation, performance parameters were measured twice, once during tests conducted in test cell number 3 and again during tests conducted in test cell number 4 of the NASA Lewis Propulsion Systems Laboratory. The analysis covers 15 engine parameters, including engine inlet airflow, engine net thrust, and engine specific fuel consumption measured at high rotor speed of 8875 rpm. Measurements were taken at three flight conditions defined by the following engine inlet pressure, engine inlet total temperature, and engine ram ratio: (1) 82.7 kPa, 288 K, 1.0, (2) 82.7 kPa, 288 K, 1.3, and (3) 20.7 kPa, 288 K, 1.3. In terms of bias, precision, and uncertainty magnitudes, there were no differences between most measurements made in test cells number 3 and 4. The magnitude of the errors increased for both test cells as engine pressure level decreased. Also, the level of the bias error was two to three times larger than that of the precision error.

Water Quality in the Arthur R. Marshall Loxahatchee National Wildlife Refuge - Trends and Spatial Characteristics of Selected Constituents, 1974-2004

USGS Publications Warehouse

Miller, Ronald L.; McPherson, Benjamin F.

2008-01-01

Water quality in the interior marsh of the Arthur R. Marshall Loxahatchee National Wildlife Refuge is characterized by low concentrations of major ions, principally sodium and chloride, and is affected primarily by natural seasonal processes, such as evapotranspiration, rainfall, and biological activity. During the dry season, evapotranspiration exceeds precipitation, and specific conductance and conservative ion concentrations at marsh background sites typically increase by 40-70 percent between the end of the rainy season in September and the end of the dry season in May. Water enters the Refuge mainly from rainfall and perimeter canals. Water is pumped into the perimeter canals from large pumping stations, such as S-5A and S-6. In recent years, much of the water pumped into the Refuge passes through Stormwater Treatment Areas (STAs) before being released into the perimeter canals that surround the Refuge. Since 2001, water at S-6 has been diverted south toward STA-2, away from the Refuge perimeter canals. Water from S-5A and S-6 flows through agricultural lands with intense agricultural activity and typically contains relatively high concentrations of major ions, nutrients, and pesticides. Specific conductance, major-ion concentrations, and nutrient concentrations are an order of magnitude higher at S-5A and S-6 canal sites than at interior marsh sites. Water quality in the marsh bordering the canals can be affected substantially by the canal water, and these effects can extend several miles or more into the marsh depending on location in the Refuge and on the water level in the canals. As canal water flows into the marsh, processes such as uptake by periphyton and rooted vegetation and settling of particulate matter reduce the concentrations of nutrients to a greater extent than conservative ions such as chloride. Long- and short-term trends for specific conductance, chloride ion, sulfate ion, total phosphorus, and total nitrogen at five sites were evaluated primarily using an uncensored seasonal Kendall test with a water-level adjustment to reduce the effects of long wet or dry periods. Significant long-term trends (1974-2003) for specific conductance, chloride, total phosphorus, and total nitrogen at canal sites S-5A and S-6 were generally downward. Of the five sites, S-5A had the most pronounced decline for specific conductance at about -340 microsiemens per centimeter (?S/cm), followed by S-6 with a decline of about -280 ?S/cm. The two internal marsh sites, LOX8 and LOX13, had significant long-term trends in specific conductance of about +37 and -36 ?S/cm, respectively. Long-term trends for other constituents at the two internal marsh sites were generally small in magnitude or not measurable between 1978 and 2003. Marsh site LOX15 near the Hillsboro Canal showed no long-term trends, although specific conductance and sulfate concentration increased about 560 ?S/cm and 30 milligrams per liter, respectively, from 1998 to 2002. Site LOX15 is influenced strongly by intrusions of canal water, and increases in specific conductance and sulfate at this site coincided with increased canal-water inflows from STA-1W between 2001 and 2003. Median concentrations at LOX13 and S-5A were used to represent background and canal concentrations, respectively. Based on these values, the median chloride concentration at LOX15 indicates that the water is typically about 31 percent canal water and 69 percent ?natural? background water. Using median sulfate concentrations, similarly to chloride, the fraction of water at LOX15 was estimated to be 17 percent from canals and 83 percent from ?natural? background water. This finding suggests that in the low sulfate environment of the Refuge, sulfate is not conservative and only about half of the sulfate from canal water typically reaches LOX15; the rest presumably is removed by marsh plants, algae, and bottom sediments. Concentrations of pesticides and other organic compounds were measured

Fathering and adolescents' psychological adjustment: the role of fathers' involvement, residence and biology status.

PubMed

Flouri, E

2008-03-01

Studies on fathering and child mental health are now increasingly looking for specificity in children's psychological adjustment, indicating whether the impact of fathering is diagnostically specific or non-specific. Data from 435 fathers of secondary school-aged children in Britain were used to explore the association between resident biological fathers', non-resident biological fathers' and stepfathers' involvement and children's total difficulties, prosocial behaviour, emotional symptoms, conduct problems, hyperactivity and peer problems (all measured with the Strengths and Difficulties Questionnaire) in adolescence. After controlling for child-, father- and family-related factors, fathers' involvement was negatively associated with children's total difficulties and hyperactivity, was positively associated with children's prosocial behaviour, and was unrelated with children's emotional symptoms, conduct problems and peer problems. There was no non-resident biological father effect. Compared with resident biological fathers, stepfathers reported more total difficulties, conduct problems and hyperactivity in their children even after adjusting for involvement. Whether this reflects stepfathers' low tolerance levels or biological fathers' complacency, as sociobiologists would argue, or whether this is due to pre-existing predispositions of children in families which separate and restructure, to the effects of these multiple family changes or to the high exposure of children in restructured families to parental risk factors, is, given the data available and the study design, unclear. However, this study showed that, compared with their peers in biological father families, adolescents in stepfather families are perceived to be at higher risk of behaviour problems, and that father involvement is related to specific aspects of child adjustment.

MITCH Training Guide: Strategies for the Coordination of MITCH Training within a Community. A Series for Caregivers of Infants and Toddlers. Model for Interdisciplinary Training for Children with Handicaps.

ERIC Educational Resources Information Center

Monroe County School District, Key West, FL.

This guide describes the Model of Interdisciplinary Training for Children with Handicaps (MITCH) program and suggests ways to implement this training program for Florida caregivers of infants and toddlers with disabilities on a local level. It includes guidelines for conducting training sessions and for training instructors. Specifically, the…

Institutional Effectiveness Assessment Process, 1992-93. Executive Summary. Hospitality and Service Occupations Division, Food Sciences Department, Food Production Program, Food Production Management Program, Pastry and Specialty Baking Program.

ERIC Educational Resources Information Center

South Seattle Community Coll., Washington.

In the 1992-93 academic year, the Hospitality and Food Sciences Department at South Seattle Community College conducted surveys of current and former students and local foodservice employers to determine the level of satisfaction with Department programs. Specifically, the surveys focused on four key outcomes: determining the extent to which…

Hydrologic data and description of a hydrologic monitoring plan for Medicine Lake Volcano, California

USGS Publications Warehouse

Schneider, Tiffany Rae; McFarland, W.D.

1996-01-01

A hydrologic reconnaissance of the Medicine Lake Volcano area was done to collect data needed for the design of a hydrologic monitoring plan. The reconnaissance was completed during two field trips made in June and September 1992, during which geothermal and hydrologic features of public interest in the Medicine Lake area were identified. Selected wells, springs, and geothermal features were located and documented, and initial water-level, discharge, temperature, and specific-conductance measurements were made. Lakes in the study area also were surveyed during the September field trip. Temperature, specific- conductance, dissolved oxygen, and pH data were collected by using a multiparameter probe. The proposed monitoring plan includes measurement of water levels in wells, discharge from springs, and lake stage, as well as analysis of well-,spring-, and lake-water quality. In determining lake-water quality, data for both stratified and unstratified conditions would be considered. (Data for stratified conditions were collected during the reconnaissance phase of this project, but data for unstratified conditions were not.) In addition, lake stage also would be monitored. A geothermal feature near Medicine Lake is a "hot spot" from which hot gases discharge from two distinct vents. Gas chemistry and temperature would be monitored in one of these vents.

Detection of human fecal contamination by nifH gene quantification of marine waters in the coastal beaches of Rio de Janeiro, Brazil.

PubMed

Oliveira, Samara Sant'Anna; Sorgine, Marcos Henrique Ferreira; Bianco, Kayo; Pinto, Leonardo Henriques; Barreto, Camila; Albano, Rodolpho Mattos; Cardoso, Alexander Machado; Clementino, Maysa Mandetta

2016-12-01

The identification of fecal pollution in aquatic ecosystems is one of the requirements to assess the possible risks to human health. In this report, physicochemical parameters, Escherichia coli enumeration and Methanobrevibacter smithii nifH gene quantification were conducted at 13 marine waters in the coastal beaches of Rio de Janeiro, Brazil. The pH, turbidity, dissolved oxygen, temperature, and conductivity, carried out by mobile equipment, revealed varied levels due to specific conditions of the beaches. The bioindicators' enumerations were done by defined substrate method, conventional, and real-time PCR. Six marine beach sites (46 %) presenting E. coli levels in compliance with Brazilian water quality guidelines (<2500 MPN/100 mL) showed nifH gene between 5.7 × 10 9 to 9.5 × 10 11 copies. L -1 revealing poor correlation between the two approaches. To our knowledge, this is the first inquiry in qPCR using nifH gene as a biomarker of human-specific sources of sewage pollution in marine waters in Brazil. In addition, our data suggests that alternative indicator nifH gene could be used, in combination with other markers, for source tracking studies to measure the quality of marine ecosystems thereby contributing to improved microbial risk assessment.

Prospective relations between family conflict and adolescent maladjustment: security in the family system as a mediating process.

PubMed

Cummings, E Mark; Koss, Kalsea J; Davies, Patrick T

2015-04-01

Conflict in specific family systems (e.g., interparental, parent-child) has been implicated in the development of a host of adjustment problems in adolescence, but little is known about the impact of family conflict involving multiple family systems. Furthermore, questions remain about the effects of family conflict on symptoms of specific disorders and adjustment problems and the processes mediating these effects. The present study prospectively examines the impact of family conflict and emotional security about the family system on adolescent symptoms of specific disorders and adjustment problems, including the development of symptoms of anxiety, depression, conduct problems, and peer problems. Security in the family system was examined as a mediator of these relations. Participants included 295 mother-father-adolescent families (149 girls) participating across three annual time points (grades 7-9). Including auto-regressive controls for initial levels of emotional insecurity and multiple adjustment problems (T1), higher-order emotional insecurity about the family system (T2) mediated relations between T1 family conflict and T3 peer problems, anxiety, and depressive symptoms. Further analyses supported specific patterns of emotional security/insecurity (i.e., security, disengagement, preoccupation) as mediators between family conflict and specific domains of adolescent adjustment. Family conflict was thus found to prospectively predict the development of symptoms of multiple specific adjustment problems, including symptoms of depression, anxiety, conduct problems, and peer problems, by elevating in in adolescent's emotional insecurity about the family system. The clinical implications of these findings are considered.

Virological outcome after structured interruption of antiretroviral therapy for human immunodeficiency virus infection is associated with the functional profile of virus-specific CD8+ T cells.

PubMed

Daucher, Marybeth; Price, David A; Brenchley, Jason M; Lamoreaux, Laurie; Metcalf, Julia A; Rehm, Catherine; Nies-Kraske, Elizabeth; Urban, Elizabeth; Yoder, Christian; Rock, Diane; Gumkowski, Julie; Betts, Michael R; Dybul, Mark R; Douek, Daniel C

2008-04-01

A clear understanding of the antiviral effects of CD8(+) T cells in the context of chronic human immunodeficiency virus (HIV) infection is critical for the development of prophylactic vaccines and therapeutics designed to support T-cell-mediated immunity. However, defining the potential correlates of effective CD8(+) T-cell immunity has proven difficult; notably, comprehensive analyses have demonstrated that the size and shape of the CD8(+) T-cell response are not necessarily indicative of efficacy determined by measures of plasma viral load. Here, we conducted a detailed quantitative and qualitative analysis of CD8(+) T-cell responses to autologous virus in a cohort of six HIV-infected individuals with a history of structured interruption of antiretroviral therapy (ART) (SIT). The magnitude and breadth of the HIV-specific response did not, by themselves, explain the changes observed in plasma virus levels after the cessation of ART. Furthermore, mutational escape from targeted epitopes could not account for the differential virological outcomes in this cohort. However, the functionality of HIV-specific CD8(+) T-cell populations upon antigen encounter, determined by the simultaneous and independent measurement of five CD8(+) T-cell functions (degranulation and gamma interferon, macrophage inflammatory protein 1beta, tumor necrosis factor alpha, and interleukin-2 levels) reflected the emergent level of plasma virus, with multiple functions being elicited in those individuals with lower levels of viremia after SIT. These data show that the quality of the HIV-specific CD8(+) T-cell response, rather than the quantity, is associated with the dynamics of viral replication in the absence of ART and suggest that the effects of SIT can be assessed by measuring the functional profile of HIV-specific CD8(+) T cells.

Pain relief is associated with decreasing postural sway in patients with non-specific low back pain.

PubMed

Ruhe, Alexander; Fejer, René; Walker, Bruce

2012-03-21

Increased postural sway is well documented in patients suffering from non-specific low back pain, whereby a linear relationship between higher pain intensities and increasing postural sway has been described. No investigation has been conducted to evaluate whether this relationship is maintained if pain levels change in adults with non-specific low back pain. Thirty-eight patients with non-specific low back pain and a matching number of healthy controls were enrolled. Postural sway was measured by three identical static bipedal standing tasks of 90 sec duration with eyes closed in narrow stance on a firm surface. The perceived pain intensity was assessed by a numeric rating scale (NRS-11). The patients received three manual interventions (e.g. manipulation, mobilization or soft tissue techniques) at 3-4 day intervals, postural sway measures were obtained at each occasion. A clinically relevant decrease of four NRS scores in associated with manual interventions correlated with a significant decrease in postural sway. In contrast, if no clinically relevant change in intensity occurred (≤ 1 level), postural sway remained similar compared to baseline. The postural sway measures obtained at follow-up sessions 2 and 3 associated with specific NRS level showed no significant differences compared to reference values for the same pain score. Alterations in self-reported pain intensities are closely related to changes in postural sway. The previously reported linear relationship between the two variables is maintained as pain levels change. Pain interference appears responsible for the altered sway in pain sufferers. This underlines the clinical use of sway measures as an objective monitoring tool during treatment or rehabilitation.

Perspectives of academic faculty and clinical instructors on entry-level DPT preparation for pediatric physical therapist practice.

PubMed

Kenyon, Lisa K; Dole, Robin L; Kelly, Stephanie P

2013-12-01

To prepare students for pediatric practice, the professional (entry-level) curriculum must reflect the essential knowledge, skills, and abilities (KSA) required for pediatric physical therapist practice. The aim of this study was to develop consensus concerning the pediatric-specific KSA that should be expected of doctor of physical therapy (DPT) students at various points in the curriculum: prior to a pediatric clinical education experience, after a pediatric clinical education experience, and at the end of a DPT program. The study was conducted using the Delphi method. Purposive and snowball sampling were used to recruit pediatric academic faculty and pediatric clinical instructors. Three Web-based survey rounds were used to achieve consensus, defined as agreement among ≥70% of informants. The first round identified pediatric-specific KSA that were essential for DPT students to demonstrate at the identified points in the curriculum. In the second round, informants indicated their level of agreement with each item identified in the first round. Items that achieved consensus were included in the third round, in which informants rated the level of proficiency that DPT students should demonstrate related to pediatric-specific KSA. Consensus revealed the informants' perspectives concerning pediatric-specific KSA that a DPT student should be able to demonstrate at the identified curricular points. Consensus was reached on items in the curricular categories of basic science and foundations for practice; common pediatric diagnoses/pathologies, examination, interventions/plan of care/documentation; and general skills and abilities. Limitations included the small sample size and the potential for informants to feel uncomfortable prioritizing KSA. This study is an initial step toward identifying pediatric-specific KSA that should be demonstrated by DPT students.

Specific Conductance in the Colorado River between Glen Canyon Dam and Diamond Creek, Northern Arizona, 1988-2007

USGS Publications Warehouse

Voichick, Nicholas

2008-01-01

The construction of Glen Canyon Dam, completed in 1963, resulted in substantial physical and biological changes to downstream Colorado River environments between Lake Powell and Lake Mead - an area almost entirely within Grand Canyon National Park, Ariz. In an effort to understand these changes, data have been collected to assess the condition of a number of downstream resources. In terms of measuring water quality, the collection of specific-conductance data is a cost-effective method for estimating salinity. Data-collection activities were initially undertaken by the Bureau of Reclamation's Glen Canyon Environmental Studies (1982-96); these efforts were subsequently transferred to the U.S. Geological Survey's Grand Canyon Monitoring and Research Center (1996 to the present). This report describes the specific-conductance dataset collected for the Colorado River between Glen Canyon Dam and Diamond Creek from 1988 to 2007. Data-collection and processing methods used during the study period are described, and time-series plots of the data are presented. The report also includes plots showing the relation between specific conductance and total dissolved solids. Examples of the use of specific conductance as a natural tracer of parcels of water are presented. Analysis of the data indicates that short-duration spikes and troughs in specific-conductance values lasting from hours to days are primarily the result of flooding in the Paria and Little Colorado Rivers, Colorado River tributaries below Glen Canyon Dam. Specific conductance also exhibits seasonal variations owing to changes in the position of density layers within the reservoir; these changes are driven by inflow hydrology, meteorological conditions, and background stratification. Longer term trends in Colorado River specific conductance are reflective of climatological conditions in the upper Colorado River Basin. For example, drought conditions generally result in an increase in specific conductance in Lake Powell. Therefore, the average annual specific conductance below Glen Canyon Dam is inversely related to the volume of water in Lake Powell.

Interaction-induced conducting-non-conducting transition of ultra-cold atoms in one-dimensional optical lattices

NASA Astrophysics Data System (ADS)

Chien, Chih-Chun; Gruss, Daniel; Di Ventra, Massimiliano; Zwolak, Michael

2013-06-01

The study of time-dependent, many-body transport phenomena is increasingly within reach of ultra-cold atom experiments. We show that the introduction of spatially inhomogeneous interactions, e.g., generated by optically controlled collisions, induce negative differential conductance in the transport of atoms in one-dimensional optical lattices. Specifically, we simulate the dynamics of interacting fermionic atoms via a micro-canonical transport formalism within both a mean-field and a higher-order approximation, as well as with a time-dependent density-matrix renormalization group (DMRG). For weakly repulsive interactions, a quasi-steady-state atomic current develops that is similar to the situation occurring for electronic systems subject to an external voltage bias. At the mean-field level, we find that this atomic current is robust against the details of how the interaction is switched on. Further, a conducting-non-conducting transition exists when the interaction imbalance exceeds some threshold from both our approximate and time-dependent DMRG simulations. This transition is preceded by the atomic equivalent of negative differential conductivity observed in transport across solid-state structures.

Whole-body voxel-based personalized dosimetry: Multiple voxel S-value approach for heterogeneous media with non-uniform activity distributions.

PubMed

Lee, Min Sun; Kim, Joong Hyun; Paeng, Jin Chul; Kang, Keon Wook; Jeong, Jae Min; Lee, Dong Soo; Lee, Jae Sung

2017-12-14

Personalized dosimetry with high accuracy is becoming more important because of the growing interests in personalized medicine and targeted radionuclide therapy. Voxel-based dosimetry using dose point kernel or voxel S-value (VSV) convolution is available. However, these approaches do not consider medium heterogeneity. Here, we propose a new method for whole-body voxel-based personalized dosimetry for heterogeneous media with non-uniform activity distributions, which is referred to as the multiple VSV approach. Methods: The multiple numbers (N) of VSVs for media with different densities covering the whole-body density ranges were used instead of using only a single VSV for water. The VSVs were pre-calculated using GATE Monte Carlo simulation; those were convoluted with the time-integrated activity to generate density-specific dose maps. Computed tomography-based segmentation was conducted to generate binary maps for each density region. The final dose map was acquired by the summation of N segmented density-specific dose maps. We tested several sets of VSVs with different densities: N = 1 (single water VSV), 4, 6, 8, 10, and 20. To validate the proposed method, phantom and patient studies were conducted and compared with direct Monte Carlo, which was considered the ground truth. Finally, patient dosimetry (10 subjects) was conducted using the multiple VSV approach and compared with the single VSV and organ-based dosimetry approaches. Errors at the voxel- and organ-levels were reported for eight organs. Results: In the phantom and patient studies, the multiple VSV approach showed significant improvements regarding voxel-level errors, especially for the lung and bone regions. As N increased, voxel-level errors decreased, although some overestimations were observed at lung boundaries. In the case of multiple VSVs ( N = 8), we achieved voxel-level errors of 2.06%. In the dosimetry study, our proposed method showed much improved results compared to the single VSV and organ-based dosimetry. Errors at the organ-level were -6.71%, 2.17%, and 227.46% for the single VSV, multiple VSV, and organ-based dosimetry, respectively. Conclusion: The multiple VSV approach for heterogeneous media with non-uniform activity distributions offers fast personalized dosimetry at whole-body level, yielding results comparable to those of the direct Monte Carlo approach. Copyright © 2017 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Task-specific image partitioning.

PubMed

Kim, Sungwoong; Nowozin, Sebastian; Kohli, Pushmeet; Yoo, Chang D

2013-02-01

Image partitioning is an important preprocessing step for many of the state-of-the-art algorithms used for performing high-level computer vision tasks. Typically, partitioning is conducted without regard to the task in hand. We propose a task-specific image partitioning framework to produce a region-based image representation that will lead to a higher task performance than that reached using any task-oblivious partitioning framework and existing supervised partitioning framework, albeit few in number. The proposed method partitions the image by means of correlation clustering, maximizing a linear discriminant function defined over a superpixel graph. The parameters of the discriminant function that define task-specific similarity/dissimilarity among superpixels are estimated based on structured support vector machine (S-SVM) using task-specific training data. The S-SVM learning leads to a better generalization ability while the construction of the superpixel graph used to define the discriminant function allows a rich set of features to be incorporated to improve discriminability and robustness. We evaluate the learned task-aware partitioning algorithms on three benchmark datasets. Results show that task-aware partitioning leads to better labeling performance than the partitioning computed by the state-of-the-art general-purpose and supervised partitioning algorithms. We believe that the task-specific image partitioning paradigm is widely applicable to improving performance in high-level image understanding tasks.

Conversion of transuranic waste to low level waste by decontamination: a site specific update

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allen, R.P.; Hazelton, R.F.

1985-09-01

As a followup to an FY-1984 cost/benefit study, a program was conducted in FY-1985 to transfer to the relevant DOE sites the information and technology for the direct conversion of transuranic (TRU) waste to low-level waste (LLW) by decontamination. As part of this work, the economic evaluation of the various TRUW volume reduction and conversion options was updated and expanded to include site-specific factors. The results show, for the assumptions used, that size reduction, size reduction followed by decontamination, or in situ decontamination are cost effective compared with the no-processing option. The technology transfer activities included site presentations and discussionsmore » with operations and waste management personnel to identify application opportunities and site-specific considerations and constraints that could affect the implementation of TRU waste conversion principles. These discussions disclosed definite potential for the beneficial application of these principles at most of the sites, but also confirmed the existence of site-specific factors ranging from space limitations to LLW disposal restrictions that could preclude particular applications or diminish expected benefits. 8 refs., 2 figs., 4 tabs.« less

Effects of water-control structures on hydrologic and water-quality characteristics in selected agricultural drainage canals in eastern North Carolina

USGS Publications Warehouse

Treece, M.W.; Jaynes, M.L.

1994-01-01

November of water into and out of tidally affected canals in eastern North Carolina was documented before and after the installation of water-control structures. Water levels in five of the canals downstream from the water-control structures were controlled primarily by water-level fluctuations in estuarine receiving waters. Water-control structures also altered upstream water levels in all canals. Water levels were lowered upstream from tide gates, but increased upstream from flashboard risers. Both types of water-control structures attenuated the release of runoff following rainfall events, but in slightly different ways. Tide gates appeared to reduce peak discharge rates associated with rainfall, and flashboard risers lengthened the duration of runoff release. Tide gates had no apparent effect on pH, dissolved oxygen, suspended-sediment, or total phosphorus concentrations downstream from the structures. Specific conductance measured from composite samples collected with automatic samples increased downstream of tide gates after installation. Median concentrations of nitrite plus nitrate nitrogen were near the minimum detection level throughout the study; however, the number of observations of concentrations exceeding 0.1 milligram per liter dropped significantly after tide gates were installed. Following tide-gate installation, instantaneous loadings of nitrite plus nitrate nitrogen were significantly reduced at one test site, but this reduction was not observed at the other test site. Loadings of other nutrient species and suspended sediment did not change at the tide-gate test sites after tide-gate installation. Specific conductance was lower in the Beaufort County canals than in the Hyde County canals. Although there was a slight increase in median values at the flashboard-riser sites, the mean and maximum values declined substantially downstream from the risers following installation. This decline of specific conductance in the canals occurred despite a large increase of specific conductance in the tidal creek. Flashboard risers had no significant effect on concentrations of dissolved oxygen, suspended sediment, total ammonia plus organic nitrogen, or phosphorus. Maximum concentrations of ammonia nitrogen were smaller at both test sites after riser installation. In addition, concentrations of nitrite plus nitrate nitrogen exceeding 1.0 milligram per liter rarely occurred at the flashboard-riser test sites following installation of the risers. Median loadings of nitrite plus nitrate nitrogen and total nitrogen decreased at one riser test site following flashboard-riser installation. Tide gates and flashboard risers were associated with reductions in concentrations and export of nitrite plus nitrate nitrogen; however, these changes should be interpreted cautiously because reductions were not observed consistently at every site. The hydrology and baseline water-quality characteristics of the two study areas differ, making comparisons of the effectiveness of the two types of water-control structures difficult to interpret. The effects of water-control structures on the hydrology of the drainage canals are more meaningful than the changes in water quality. Tide gates and flashboard risers altered the hydrologic characteristics of the drainage canals and created an environment favorable for nutrient loss or transformation. Both structures retained agricultural drainage upstream, which increased potential storage for infiltration and reduced the potential for surface runoff, sediment, and nutrient transport, and higher peak outflow rates.

Fermi Level Manipulation through Native Doping in the Topological Insulator Bi2Se3.

PubMed

Walsh, Lee A; Green, Avery J; Addou, Rafik; Nolting, Westly; Cormier, Christopher R; Barton, Adam T; Mowll, Tyler R; Yue, Ruoyu; Lu, Ning; Kim, Jiyoung; Kim, Moon J; LaBella, Vincent P; Ventrice, Carl A; McDonnell, Stephen; Vandenberghe, William G; Wallace, Robert M; Diebold, Alain; Hinkle, Christopher L

2018-06-08

The topologically protected surface states of three-dimensional (3D) topological insulators have the potential to be transformative for high-performance logic and memory devices by exploiting their specific properties such as spin-polarized current transport and defect tolerance due to suppressed backscattering. However, topological insulator based devices have been underwhelming to date primarily due to the presence of parasitic issues. An important example is the challenge of suppressing bulk conduction in Bi 2 Se 3 and achieving Fermi levels ( E F ) that reside in between the bulk valence and conduction bands so that the topologically protected surface states dominate the transport. The overwhelming majority of the Bi 2 Se 3 studies in the literature report strongly n-type materials with E F in the bulk conduction band due to the presence of a high concentration of selenium vacancies. In contrast, here we report the growth of near-intrinsic Bi 2 Se 3 with a minimal Se vacancy concentration providing a Fermi level near midgap with no extrinsic counter-doping required. We also demonstrate the crucial ability to tune E F from below midgap into the upper half of the gap near the conduction band edge by controlling the Se vacancy concentration using post-growth anneals. Additionally, we demonstrate the ability to maintain this Fermi level control following the careful, low-temperature removal of a protective Se cap, which allows samples to be transported in air for device fabrication. Thus, we provide detailed guidance for E F control that will finally enable researchers to fabricate high-performance devices that take advantage of transport through the topologically protected surface states of Bi 2 Se 3 .

An Application of the SSHAC Level 3 Process to the Probabilistic Seismic Hazard Analysis for Nuclear Facilities at the Hanford Site, Eastern Washington, USA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coppersmith , Kevin J.; Bommer, Julian J.; Bryce, Robert W.

Under the sponsorship of the US Department of Energy (DOE) and the electric utility Energy Northwest, the Pacific Northwest National Laboratory (PNNL) is conducting a probabilistic seismic hazard analysis (PSHA) within the framework of a SSHAC Level 3 procedure (Senior Seismic Hazard Analysis Committee; Budnitz et al., 1997). Specifically, the project is being conducted following the guidelines and requirements specified in NUREG-2117 (USNRC, 2012b) and consistent with approach given in the American Nuclear Standard ANSI/ANS-2.29-2008 Probabilistic Seismic Hazard Analysis. The collaboration between DOE and Energy Northwest is spawned by the needs of both organizations for an accepted PSHA with highmore » levels of regulatory assurance that can be used for the design and safety evaluation of nuclear facilities. DOE committed to this study after performing a ten-year review of the existing PSHA, as required by DOE Order 420.1C. The study will also be used by Energy Northwest as a basis for fulfilling the NRC’s 10CFR50.54(f) requirement that the western US nuclear power plants conduct PSHAs in conformance with SSHAC Level 3 procedures. The study was planned and is being carried out in conjunction with a project Work Plan, which identifies the purpose of the study, the roles and responsibilities of all participants, tasks and their associated schedules, Quality Assurance (QA) requirements, and project deliverables. New data collection and analysis activities are being conducted as a means of reducing the uncertainties in key inputs to the PSHA. It is anticipated that the results of the study will provide inputs to the site response analyses at multiple nuclear facility sites within the Hanford Site and at the Columbia Generating Station.« less

A spatial analysis of the determinants of pneumonia and influenza hospitalizations in Ontario (1992-2001).

PubMed

Crighton, Eric J; Elliott, Susan J; Moineddin, Rahim; Kanaroglou, Pavlos; Upshur, Ross

2007-04-01

Previous research on the determinants of pneumonia and influenza has focused primarily on the role of individual level biological and behavioural risk factors resulting in partial explanations and largely curative approaches to reducing the disease burden. This study examines the geographic patterns of pneumonia and influenza hospitalizations and the role that broad ecologic-level factors may have in determining them. We conducted a county level, retrospective, ecologic study of pneumonia and influenza hospitalizations in the province of Ontario, Canada, between 1992 and 2001 (N=241,803), controlling for spatial dependence in the data. Non-spatial and spatial regression models were estimated using a range of environmental, social, economic, behavioural, and health care predictors. Results revealed low education to be positively associated with hospitalization rates over all age groups and both genders. The Aboriginal population variable was also positively associated in most models except for the 65+-year age group. Behavioural factors (daily smoking and heavy drinking), environmental factors (passive smoking, poor housing, temperature), and health care factors (influenza vaccination) were all significantly associated in different age and gender-specific models. The use of spatial error regression models allowed for unbiased estimation of regression parameters and their significance levels. These findings demonstrate the importance of broad age and gender-specific population-level factors in determining pneumonia and influenza hospitalizations, and illustrate the need for place and population-specific policies that take these factors into consideration.

Lightning protection for shuttle propulsion elements

NASA Technical Reports Server (NTRS)

Goodloe, Carolyn C.; Giudici, Robert J.

1991-01-01

The results of lightning protection analyses and tests are weighed against the present set of waivers to the NASA lightning protection specification. The significant analyses and tests are contrasted with the release of a new and more realistic lightning protection specification, in September 1990, that resulted in an inordinate number of waivers. A variety of lightning protection analyses and tests of the Shuttle propulsion elements, the Solid Rocket Booster, the External Tank, and the Space Shuttle Main Engine, were conducted. These tests range from the sensitivity of solid propellant during shipping to penetration of cryogenic tanks during flight. The Shuttle propulsion elements have the capability to survive certain levels of lightning strikes at certain times during transportation, launch site operations, and flight. Changes are being evaluated that may improve the odds of withstanding a major lightning strike. The Solid Rocket Booster is the most likely propulsion element to survive if systems tunnel bond straps are improved. Wiring improvements were already incorporated and major protection tests were conducted. The External Tank remains vulnerable to burn-through penetration of its skin. Proposed design improvements include the use of a composite nose cone and conductive or laminated thermal protection system coatings.

Small Launch Vehicle Concept Development for Affordable Multi-Stage Inline Configurations

NASA Technical Reports Server (NTRS)

Beers, Benjamin R.; Waters, Eric D.; Philips, Alan D.; Threet, Grady E., Jr.

2014-01-01

The Advanced Concepts Office at NASA's George C. Marshall Space Flight Center conducted a study of two configurations of a three-stage, inline, liquid propellant small launch vehicle concept developed on the premise of maximizing affordability by targeting a specific payload capability range based on current and future industry demand. The initial configuration, NESC-1, employed liquid oxygen as the oxidizer and rocket propellant grade kerosene as the fuel in all three stages. The second and more heavily studied configuration, NESC-4, employed liquid oxygen and rocket propellant grade kerosene on the first and second stages and liquid oxygen and liquid methane fuel on the third stage. On both vehicles, sensitivity studies were first conducted on specific impulse and stage propellant mass fraction in order to baseline gear ratios and drive the focus of concept development. Subsequent sensitivity and trade studies on the NESC-4 concept investigated potential impacts to affordability due to changes in gross liftoff mass and/or vehicle complexity. Results are discussed at a high level to understand the impact severity of certain sensitivities and how those trade studies conducted can either affect cost, performance, or both.

Serum level of soluble receptor for advanced glycation end products in asthmatic children and its correlation to severity and pulmonary functions.

PubMed

El-Seify, Magda Y Hussein; Fouda, Eman Mahmoud; Nabih, Enas Samir

2014-01-01

Soluble receptor for advanced glycation end products (sRAGE) acts as a decoy receptor for RAGE which has several distinct pro-inflammatory ligands in the extracellular compartment, and is believed to afford protection against inflammation and cell injury. This study was conducted to measure serum sRAGE in asthmatic children and to assess its correlation with clinical and functional severity and to asthma phenotype according to sputum cytology. The study was conducted on 60 asthmatic children from the Pediatric Chest Clinic, Children's Hospital, Ain Shams University. The patients were divided according to asthma control and severity. sRAGE showed statistically significant lower levels in asthmatic patients (899.1 +/- 399.8 pg/mL) compared to the control group (1406.7 +/- 474.3 pg/mL, p = 0.000), with a cut off value of asthma diagnosis of 1080.4 pg/mL with a sensitivity and specificity of 77% and 75%, respectively. Uncontrolled and severe asthmatic subgroups showed lower levels of sRAGE, cut off value of sRAGE for the severity of asthma was 829 pg/mL with 89% sensitivity and 81% specificity. Asthmatic patients stratified according to sputum cytology revealed that those with > 2% eosinophils and > or = 40% neutrophils showed lower levels of sRAGE (710 +/- 258 pg/mL) compared to those with > 2% eosinophils and < 40% neutrophils (1064 +/- 431 pg/mL) (p = 0.000). There was a highly significant positive correlation between sRAGE levels and FEV 1% (r = 0.41, p < 0.01), a highly significant negative correlation with eosinophilic count and total IgE (r = -0.49 and -0.39, respectively, p < 0.01). Serum level of sRAGE may correlate with severity of bronchial asthma clinically and functionally. It may be a target of future therapeutic interventions.

American Recovery and Reinvestment Act (ARRA) - FEMP Technical Assistance - Federal Aviation Administration - Project 209 - Control Tower and Support Building, Boise, Idaho

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arends, J.; Sandusky, William F.

2010-06-28

This report documents an energy audit performed by Pacific Northwest National Laboratory (PNNL) and Redhorse Corporation (Redhorse) conducted on the Federal Aviation Administration (FAA) control tower and base building in Boise, Idaho. This report presents findings of the energy audit team that evaluated construction documents and operating specifications (at the 100% level) followed by a site visit of the facility under construction. The focus of the review was to identify measures that could be incorporated into the final design and operating specifications that would result in additional energy savings for FAA that would not have otherwise occurred.

Altitude-chamber performance of British Rolls-Royce Nene II engine III : 18.00-inch-diameter jet nozzle

NASA Technical Reports Server (NTRS)

Grey, Ralph E; Brightwell, Virginia L; Barson, Zelmar; NACA

1950-01-01

An altitude-chamber investigation of British Rolls-Royce Nene II turbojet engine was conducted over range of altitudes from sea level to 65,000 feet and ram pressure ratios from 1.10 to 3.50, using an 18.00-inch-diameter jet nozzle. The 18.00-inch-diameter jet nozzle gave slightly lower values of net-thrust specific fuel consumption than either the 18.41- or the standard 18.75-inch-diameter jet nozzles at high flight speeds. At low flight speeds, the 18.41-inch-diameter jet nozzle gave the lowest value of net-thrust specific fuel consumption.

Predicting Trihalomethanes (THMs) in the New York City Water Supply

NASA Astrophysics Data System (ADS)

Mukundan, R.; Van Dreason, R.

2013-12-01

Chlorine, a commonly used disinfectant in most water supply systems, can combine with organic carbon to form disinfectant byproducts including carcinogenic trihalomethanes (THMs). We used water quality data from 24 monitoring sites within the New York City (NYC) water supply distribution system, measured between January 2009 and April 2012, to develop site-specific empirical models for predicting total trihalomethane (TTHM) levels. Terms in the model included various combinations of the following water quality parameters: total organic carbon, pH, specific conductivity, and water temperature. Reasonable estimates of TTHM levels were achieved with overall R2 of about 0.87 and predicted values within 5 μg/L of measured values. The relative importance of factors affecting TTHM formation was estimated by ranking the model regression coefficients. Site-specific models showed improved model performance statistics compared to a single model for the entire system most likely because the single model did not consider locational differences in the water treatment process. Although never out of compliance in 2011, the TTHM levels in the water supply increased following tropical storms Irene and Lee with 45% of the samples exceeding the 80 μg/L Maximum Contaminant Level (MCL) in October and November. This increase was explained by changes in water quality parameters, particularly by the increase in total organic carbon concentration and pH during this period.

Connection, regulation, and care plan innovation: a case study of four nursing homes.

PubMed

Colón-Emeric, Cathleen S; Lekan-Rutledge, Deborah; Utley-Smith, Queen; Ammarell, Natalie; Bailey, Donald; Piven, Mary L; Corazzini, Kirsten; Anderson, Ruth A

2006-01-01

We describe how connections among nursing home staff impact the care planning process using a complexity science framework. We completed six-month case studies of four nursing homes. Field observations (n = 274), shadowing encounters (n = 69), and in-depth interviews (n = 122) of 390 staff at all levels were conducted. Qualitative analysis produced a conceptual/thematic description and complexity science concepts were used to produce conceptual insights. We observed that greater levels of staff connection were associated with higher care plan specificity and innovation. Connection of the frontline nursing staff was crucial for (1) implementation of the formal care plan and (2) spontaneous informal care planning responsive to changing resident needs. Although regulations could theoretically improve cognitive diversity and information flow in care planning, we observed instances of regulatory oversight resulting in less specific care plans and abandonment of an effective care planning process. Interventions which improve staff connectedness may improve resident outcomes.

Renewable Energy Feasibility Study Leading to Development of the Native Spirit Solar Energy Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carolyn Stewart; Tracey LeBeau

2008-01-31

DOE-funded renewable energy feasibility study conducted by Red Mountain Tribal Energy on behalf of the Southwest Tribal Energy Consortium (SWTEC). During the course of the study, SWTEC members considered multiple options for the organization structure, selected a proposed organization structure, and drafted a Memorandum of Understanding for the SWTEC organization. High-level resource assessments for SWTEC members were completed; surveys were developed and completed to determine each member’s interest in multiple participation options, including on-reservation projects. With the survey inputs in mind, multiple energy project options were identified and evaluated on a high-level basis. That process led to a narrowing ofmore » the field of technology options to solar generation, specifically, utility-scale Concentrating Solar-Powered Generation projects, with a specific, tentative project location identified at the Fort Mojave Indian Reservation -- the Native Spirit Solar Energy Facility.« less

Design review report for the SY-101 RAPID mitigation system

DOE Office of Scientific and Technical Information (OSTI.GOV)

SCHLOSSER, R.L.

1999-05-24

This report documents design reviews conducted of the SY-101 Respond And Pump In Days (RAPID) Mitigation System. As part of the SY-101 Surface-Level-Rise Remediation Project, the SY-101 WID Mitigation System will reduce the potential unacceptable consequences of crust growth in Tank 241-SY-101 (SY-101). Projections of the crust growth rate indicate that the waste level in the tank may reach the juncture of the primary and secondary confinement structures of the tank late in 1999. Because of this time constraint, many design activities are being conducted in parallel and design reviews were conducted for system adequacy as well as design implementationmore » throughout the process. Design implementation, as used in this design review report, is the final component selection (e.g., which circuit breaker, valve, or thermocouple) that meets the approved design requirements, system design, and design and procurement specifications. Design implementation includes the necessary analysis, testing, verification, and qualification to demonstrate compliance with the system design and design requirements. Design implementation is outside the scope of this design review. The design activities performed prior to detailed design implementation (i.e., system mission requirements, functional design requirements, technical criteria, system conceptual design, and where design and build contracts were placed, the procurement specification) have been reviewed and are within the scope of this design review report. Detailed design implementation will be controlled, reviewed, and where appropriate, approved in accordance with Tank Waste Remediation System (TWRS) engineering procedures. Review of detailed design implementation will continue until all components necessary to perform the transfer function are installed and tested.« less

Groundwater conditions and studies in the Brunswick–Glynn County area, Georgia, 2008

USGS Publications Warehouse

Cherry, Gregory S.; Peck, Michael F.; Painter, Jaime A.; Stayton, Welby L.

2010-01-01

The Upper Floridan aquifer is contaminated with saltwater in a 2-square-mile area of downtown Brunswick, Georgia. This contamination has limited development of the groundwater supply in the Glynn County area. Hydrologic, geologic, and water-quality data are needed to effectively manage water resources. Since 1959, the U.S. Geological Survey has conducted a cooperative water program with the City of Brunswick to monitor and assess the effect of groundwater development on saltwater contamination of the Floridan aquifer system. During calendar year 2008, the cooperative water program included continuous water-level recording of 12 wells completed in the Floridan, Brunswick, and surficial aquifer systems; collecting water levels from 21 wells to map the potentiometric surface of the Upper Floridan aquifer during July 2008; and collecting and analyzing water samples from 26 wells to map chloride concentrations in the Upper Floridan aquifer during July 2008. Equipment was installed on 3 wells for real-time water level and specific conductance monitoring. In addition, work was continued to refine an existing groundwater-flow model for evaluation of water-management scenarios.

Characterization of soil spatial variability for site-specific management using soil electrical conductivity and other remotely sensed data

NASA Astrophysics Data System (ADS)

Bang, Jisu

Field-scale characterization of soil spatial variability using remote sensing technology has potential for achieving the successful implementation of site-specific management (SSM). The objectives of this study were to: (i) examine the spatial relationships between apparent soil electrical conductivity (EC a) and soil chemical and physical properties to determine if EC a could be useful to characterize soil properties related to crop productivity in the Coastal Plain and Piedmont of North Carolina; (ii) evaluate the effects of in-situ soil moisture variation on ECa mapping as a basis for characterization of soil spatial variability and as a data layer in cluster analysis as a means of delineating sampling zones; (iii) evaluate clustering approaches using different variable sets for management zone delineation to characterize spatial variability in soil nutrient levels and crop yields. Studies were conducted in two fields in the Piedmont and three fields in the Coastal Plain of North Carolina. Spatial measurements of ECa via electromagnetic induction (EMI) were compared with soil chemical parameters (extractable P, K, and micronutrients; pH, cation exchange capacity [CEC], humic matter or soil organic matter; and physical parameters (percentage sand, silt, and clay; and plant-available water [PAW] content; bulk density; cone index; saturated hydraulic conductivity [Ksat] in one of the coastal plain fields) using correlation analysis across fields. We also collected ECa measurements in one coastal plain field on four days with significantly different naturally occurring soil moisture conditions measured in five increments to 0.75 m using profiling time-domain reflectometry probes to evaluate the temporal variability of ECa associated with changes in in-situ soil moisture content. Nonhierarchical k-means cluster analysis using sensor-based field attributes including vertical ECa, near-infrared (NIR) radiance of bare-soil from an aerial color infrared (CIR) image, elevation, slope, and their combinations was performed to delineate management zones. The strengths and signs of the correlations between ECa and measured soil properties varied among fields. Few strong direct correlations were found between ECa and the soil chemical and physical properties studied (r2 < 0.50), but correlations improved considerably when zone mean ECa and zone means of selected soil properties among ECa zones were compared. The results suggested that field-scale ECa survey is not able to directly predict soil nutrient levels at any specific location, but could delimit distinct zones of soil condition among which soil nutrient levels differ, providing an effective basis for soil sampling on a zone basis. (Abstract shortened by UMI.)

Surface vapor conductance derived from the ETRHEQ: Dependence on environmental variables and similarity to Oren's stomatal stress model for vapor pressure deficit

NASA Astrophysics Data System (ADS)

Salvucci, G.; Rigden, A. J.

2015-12-01

Daily time series of evapotranspiration and surface conductance to water vapor were estimated using the ETRHEQ method (Evapotranspiration from Relative Humidity at Equilibrium). ETRHEQ has been previously compared with ameriflux site-level measurements of ET at daily and seasonal time scales, with watershed water balance estimates, and with various benchmark ET data sets. The ETRHEQ method uses meteorological data collected at common weather stations and estimates the surface conductance by minimizing the vertical variance of the calculated relative humidity profile averaged over the day. The key advantage of the ETRHEQ method is that it does not require knowledge of the surface state (soil moisture, stomatal conductance, leaf are index, etc.) or site-specific calibration. The daily estimates of conductance from 229 weather stations for 53 years were analyzed for dependence on environmental variables known to impact stomatal conductance and soil diffusivity: surface temperature, surface vapor pressure deficit, solar radiation, antecedent precipitation (as a surrogate for soil moisture), and a seasonal vegetation greenness index. At each site the summertime (JJAS) conductance values estimated from ETRHEQ were fitted to a multiplicate Jarvis-type stress model. Functional dependence was not proscribed, but instead fitted using flexible piecewise-linear splines. The resulting stress functions reproduce the time series of conductance across a wide range of ecosystems and climates. The VPD stress term resembles that proposed by Oren (i.e., 1-m*log(VPD) ), with VPD measured in kilopascals. The equivalent value of m derived from our spline-fits at each station varied over a remarkably small range of 0.58 to 0.62, in agreement with Oren's original analysis based on leaf and tree-level measurements.

Confounding adjustment in comparative effectiveness research conducted within distributed research networks.

PubMed

Toh, Sengwee; Gagne, Joshua J; Rassen, Jeremy A; Fireman, Bruce H; Kulldorff, Martin; Brown, Jeffrey S

2013-08-01

A distributed research network (DRN) of electronic health care databases, in which data reside behind the firewall of each data partner, can support a wide range of comparative effectiveness research (CER) activities. An essential component of a fully functional DRN is the capability to perform robust statistical analyses to produce valid, actionable evidence without compromising patient privacy, data security, or proprietary interests. We describe the strengths and limitations of different confounding adjustment approaches that can be considered in observational CER studies conducted within DRNs, and the theoretical and practical issues to consider when selecting among them in various study settings. Several methods can be used to adjust for multiple confounders simultaneously, either as individual covariates or as confounder summary scores (eg, propensity scores and disease risk scores), including: (1) centralized analysis of patient-level data, (2) case-centered logistic regression of risk set data, (3) stratified or matched analysis of aggregated data, (4) distributed regression analysis, and (5) meta-analysis of site-specific effect estimates. These methods require different granularities of information be shared across sites and afford investigators different levels of analytic flexibility. DRNs are growing in use and sharing of highly detailed patient-level information is not always feasible in DRNs. Methods that incorporate confounder summary scores allow investigators to adjust for a large number of confounding factors without the need to transfer potentially identifiable information in DRNs. They have the potential to let investigators perform many analyses traditionally conducted through a centralized dataset with detailed patient-level information.

Nutrient and carbon availability influences on denitrification in the regulated Lower Colorado River, Austin

NASA Astrophysics Data System (ADS)

Spector, J.

2016-12-01

The Lower Colorado River in Austin, Texas receives nitrogen-rich runoff and treated wastewater effluent and is subject to periodic water releases from the Longhorn Dam, which cause fluctuations in groundwater stage downstream. This research examined groundwater denitrification at the Hornsby Bend riparian area (located approximately 24 km downstream of downtown Austin) and characterized how dam-induced hyporheic exchange affects denitrification rates. Conductivity, temperature, water level, and dissolved oxygen concentrations were measured continuously throughout flood pulses for six months using dataloggers installed in a transect of seven monitoring wells on the river bank. Hourly samples were collected using an autosampler in one monitoring well (MW-5) during various flood conditions during the six month monitoring period. Water samples were analyzed for total organic carbon, total nitrogen, anions (NO3- and NO2-), NH4+ concentrations, alkalinity, and specific ultraviolet absorbance (SUVA) to characterize dissolved organic matter. Following large flood events (up to 4 m of water level stage increase), average conductivity increased 300 µs/centimeter in MW-5 as the water level receded. Analysis of water samples indicated that NO3- reduction occurred as conductivity and alkalinity increased. In addition, NH4+ concentrations increased during high conductivity periods. Increased denitrification activity corresponded with high SUVA. High conductivity and alkalinity increase the availability of electron donors (HCO3- and CO32-) and enhances denitrification potential. Higher SUVA values indicate increased dissolved organic carbon aromaticity and corresponding NO3- reduction. Additionally, changes in dissolved organic matter lability indicate the residence times of possible reactive organic carbon in the riparian area. This study has implications for determining advantageous geochemical conditions for hyporheic zone denitrification following large flood events.

Continuous tidal streamflow, water level, and specific conductance data for Union Creek and the Little Back, Middle, and Front Rivers, Savannah River Estuary, November 2008 to March 2009

USGS Publications Warehouse

Lanier, Timothy H.; Conrads, Paul

2010-01-01

In the Water Resource Development Act of 1999, the U.S. Congress authorized the deepening of the Savannah Harbor. Additional studies were then identified by the Georgia Ports Authority and other local and regional stakeholders to determine and fully describe the potential environmental effects of deepening the channel. One need that was identified was the validation of a three-dimensional hydrodynamic model developed to evaluate mitigation scenarios for a potential harbor deepening and the effects on the Savannah River estuary. The streamflow in the estuary is very complex due to reversing tidal flows, interconnections of streams and tidal creeks, and the daily flooding and draining of the marshes. The model was calibrated using very limited streamflow data and no continuous streamflow measurements. To better characterize the streamflow dynamics and mass transport of the estuary, two index-velocity sites were instrumented with continuous acoustic velocity, water level, and specific conductance sensors on the Little Back and Middle Rivers for the 5-month period of November 2008 through March 2009. During the same period, a third acoustic velocity meter was installed on the Front River just downstream from U.S. Geological Survey streamgaging station 02198920 (Savannah River at GA 25, at Port Wentworth, Georgia) where water level and specific conductance data were being collected. A fourth index-velocity site was instrumented with continuous acoustic velocity, water level, and specific conductance sensors on Union Creek for a 2-month period starting in November 2008. In addition to monitoring the tidal cycles, streamflow measurements were made at the four index-velocity sites to develop ratings to compute continuous discharge for each site. The maximum flood (incoming) and ebb (outgoing) tides measured on Little Back River were –4,570 and 7,990 cubic feet per second, respectively. On Middle River, the maximum flood and ebb tides measured were –9,630 and 13,600 cubic feet per second, respectively. On Front River, the maximum flood and ebb tides were –34,500 and 43,700 cubic feet per second, respectively; and on Union Creek, the maximum flood and ebb tides were –2,390 and 4,610 cubic feet per second, respectively. During the 5-month instrumentation deployment, computed tidal streamflows on Little Back River ranged from –7,820 to 9,600 cubic feet per second for the flood and ebb tides, respectively. On Middle River, the computed tidal streamflows ranged from –17,500 to 22,500 cubic feet per second for the flood and ebb tides, respectively. The computed tidal streamflows on Front River ranged from –78,900 to 87,200 cubic feet per second, and from –3,850 to 6,130 cubic feet per second on Union Creek for the flood and ebb tides, respectively. The streamgages on the Little Back, Middle, and Front Rivers have continued in operation following the initial 5-month deployment.

Racial/Ethnic Disparities in Alcohol-related Problems: Differences by Gender and Level of Heavy Drinking

PubMed Central

Witbrodt, Jane; Mulia, Nina; Zemore, Sarah E.; Kerr, William C.

2014-01-01

Objective While prior studies have reported racial/ethnic disparities in alcohol-related problems at a given level of heavy drinking, particularly lower levels, it is unclear whether these occur in both genders and are an artifact of racial/ethnic differences in drink alcohol content. Such information is important to understanding disparities and developing specific, targeted interventions. This study addresses these questions and examines disparities in specific types of alcohol problems across racial-gender groups. Method Using 2005 and 2010 National Alcohol Survey data (N=7,249 current drinkers), gender-stratified regression analyses were conducted to assess black-white and Hispanic-white disparities in alcohol dependence and negative drinking consequences at equivalent levels of heavy drinking. Heavy drinking was measured using a gender-specific, composite drinking-patterns variable derived through factor analysis. Analyses were replicated using adjusted-alcohol consumption variables that account for group differences in drink alcohol content based on race/ethnicity, gender, age and alcoholic beverage. Results Compared to white men, black and Hispanic men had higher rates of injuries/accidents/health and social consequences, and marginally greater work/legal consequences (p< .10). Hispanic women had marginally higher rates of social consequences. In main effects models controlling for demographics, light drinking and heavy drinking, only black women and men had greater odds of alcohol-related problems relative to whites. Interaction models indicated that compared to whites, black women had greater odds of dependence at all levels of heavy drinking, while both black and Hispanic men had elevated risk of alcohol problems only at lower levels of heavy drinking. Drink alcohol content adjustments did not significantly alter findings for either gender. Conclusions This study highlights the gender-specific nature of racial/ethnic disparities. Interventions focused on reducing heavy drinking might not address disparities in alcohol-related problems that exist at low levels of heavy drinking. Future research should consider the potential role of environmental and genetic factors in these disparities. PMID:24730475

Drinking motives mediate cultural differences but not gender differences in adolescent alcohol use.

PubMed

Kuntsche, Emmanuel; Wicki, Matthias; Windlin, Béat; Roberts, Chris; Gabhainn, Saoirse Nic; van der Sluijs, Winfried; Aasvee, Katrin; Gaspar de Matos, Margarida; Dankulincová, Zuzana; Hublet, Anne; Tynjälä, Jorma; Välimaa, Raili; Bendtsen, Pernille; Vieno, Alessio; Mazur, Joanna; Farkas, Judith; Demetrovics, Zsolt

2015-03-01

To test whether differences in alcohol use between boys and girls and between northern and southern/central Europe are mediated by social, enhancement, coping, and conformity motives. Cross-sectional school-based surveys were conducted among 33,813 alcohol-using 11- to 19-year-olds from northern Europe (Denmark, Estonia, Finland, Ireland, Poland, Scotland, and Wales) and southern/central Europe (Belgium, Hungary, Italy, Portugal, Slovakia, and Switzerland). Particularly in late adolescence and early adulthood, boys drank more frequently and were more often drunk than girls. Instead of mediation, gender-specific motive paths were found; 14- to 16-year-old girls drank more because of higher levels of coping motives and lower levels of conformity motives, whereas 14- to 19-year-old boys drank more because of higher levels of social and enhancement motives. Geographical analyses confirmed that adolescents from southern/central European countries drank more frequently, but those from northern Europe reported being drunk more often. The strong indirect effects demonstrate that some of the cultural differences in drinking are because of higher levels of social, enhancement, and coping motives in northern than in southern/central Europe. The results from the largest drinking motive study conducted to date suggest that gender-specific prevention should take differences in the motivational pathways toward (heavy) drinking into account, that is, positive reinforcement seems to be more important for boys and negative reinforcement for girls. Preventive action targeting social and enhancement motives and taking drinking circumstances into account could contribute to tackling underage drinking in northern Europe. Copyright © 2015 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

A meta-analysis of the literature for whole-body FDG PET detection of recurrent colorectal cancer.

PubMed

Huebner, R H; Park, K C; Shepherd, J E; Schwimmer, J; Czernin, J; Phelps, M E; Gambhir, S S

2000-07-01

A meta-analysis of the literature for the use of FDG PET in the detection of recurrent colorectal cancer (CRC) was conducted to evaluate the quality of the reported studies. Overall values for the sensitivity and specificity of whole-body FDG PET and an overall FDG PET-directed percentage change in management were also determined through this analysis. Guidelines to evaluate the articles were formulated on the basis of the U.S. medical payer source criteria for assessing studies that report information on usage of new medical technology. A metaanalysis was conducted using methodology described in the peer-reviewed literature. On the basis of the guidelines established for our review, the availability of necessary information for assessing the reliability of the FDG PET data for diagnosing recurrent CRC was less than ideal. Through a meta-analysis of 11 articles, we determined, within a 95% confidence level, an overall sensitivity of 97% (95% confidence level, 95%-99%) and an overall specificity of 76% (95% confidence level, 64%-88%) for FDG PET detecting recurrent CRC throughout the whole body. Furthermore, through pooling of the change-in-management data, an overall FDG PET-directed change in management was calculated to be 29% (95% confidence level, 25%-34%). Our review suggests that improvements can be made to more effectively report the results of these FDG PET studies. The overall values determined through the meta-analysis indicate the potential benefits of using FDG PET as a diagnostic or management tool. Furthermore, these values should prove to be useful to assess the cost-effectiveness of using FDG PET in the management of patients with recurrent CRC.

Light sensors for objective light measurement in ambulatory polysomnography.

PubMed

Schembri, Rachel; Spong, Jo; Peters, Allison; Rochford, Peter; Wilksch, Philip; O'Donoghue, Fergal J; Greenwood, Kenneth M; Barnes, Maree; Kennedy, Gerard A; Berlowitz, David J

2017-01-01

Ambulatory polysomnography (PSG) does not commonly include an objective measure of light to determine the time of lights off (Loff), and thus cannot be used to calculate important indices such as sleep onset latency and sleep efficiency. This study examined the technical specifications and appropriateness of a prototype light sensor (LS) for use in ambulatory Compumedics Somte PSG.Two studies were conducted. The first examined the light measurement characteristics of the LS when used with a portable PSG device, specifically recording trace range, linearity, sensitivity, and stability. This involved the LS being exposed to varying incandescent and fluorescent light levels in a light controlled room. Secondly, the LS was trialled in 24 home and 12 hospital ambulatory PSGs to investigate whether light levels in home and hospital settings were within the recording range of the LS, and to quantify the typical light intensity reduction at the time of Loff. A preliminary exploration of clinical utility was also conducted. Linearity between LS voltage and lux was demonstrated, and the LS trace was stable over 14 hours of recording. The observed maximum voltage output of the LS/PSG device was 250 mV, corresponding to a maximum recording range of 350 lux and 523 lux for incandescent and fluorescent light respectively. At the time of Loff, light levels were within the recording range of the LS, and on average dropped by 72 lux (9-245) in the home and 76 lux (4-348) in the hospital setting. Results suggest that clinical utility was greatest in hospital settings where patients are less mobile. The LS was a simple and effective objective marker of light level in portable PSG, which can be used to identify Loff in ambulatory PSG. This allows measurement of additional sleep indices and support with clinical decisions.

Estimation of Phonon and Carrier Thermal Conductivities for Bulk Thermoelectric Materials Using Transport Properties

NASA Astrophysics Data System (ADS)

Otsuka, Mioko; Homma, Ryoei; Hasegawa, Yasuhiro

2017-05-01

The phonon and carrier thermal conductivities of thermoelectric materials were calculated using the Wiedemann-Franz law, Boltzmann equation, and a method we propose in this study called the Debye specific heat method. We prepared polycrystalline n-type doped bismuth telluride (BiTe) and bismuth antimony (BiSb) bulk alloy samples and measured six parameters (Seebeck coefficient, resistivity, thermal conductivity, thermal diffusivity, magneto-resistivity, and Hall coefficient). The carrier density and mobility were estimated for calculating the carrier thermal conductivity by using the Boltzmann equation. In the Debye specific heat method, the phonon thermal diffusivity, and thermal conductivity were calculated from the temperature dependence of the effective specific heat by using not only the measured thermal conductivity and Debye model, but also the measured thermal diffusivity. The carrier thermal conductivity was also evaluated from the phonon thermal conductivity by using the specific heat. The ratio of carrier thermal conductivity to thermal conductivity was evaluated for the BiTe and BiSb samples, and the values obtained using the Debye specific heat method at 300 K were 52% for BiTe and <5.5% for BiSb. These values are either considerably larger or smaller than those obtained using other methods. The Dulong-Petit law was applied to validate the Debye specific heat method at 300 K, which is significantly greater than the Debye temperature of the BiTe and BiSb samples, and it was confirmed that the phonon specific heat at 300 K has been accurately reproduced using our proposed method.

Neighborhood disadvantage moderates associations of parenting and older sibling problem attitudes and behavior with conduct disorders in African American children.

PubMed

Brody, Gene H; Ge, Xiaojia; Kim, Su Yeong; Murry, Velma McBride; Simons, Ronald L; Gibbons, Frederick X; Gerrard, Meg; Conger, Rand D

2003-04-01

Data from 296 sibling pairs (mean ages 10 and 13 years), their primary caregivers, and census records were used to test the hypothesis that African American children's likelihood of developing conduct problems associated with harsh parenting, a lack of nurturant-involved parenting, and exposure to an older sibling's deviance-prone attitudes and behavior would be amplified among families residing in disadvantaged neighborhoods. A latent construct representing harsh-inconsistent parenting and low levels of nurturant-involved parenting was positively associated with younger siblings' conduct disorder symptoms, as were older siblings' problematic attitudes and behavior. These associations were strongest among families residing in the most disadvantaged neighborhoods. Future research and prevention programs should focus on the specific neighborhood processes associated with increased vulnerability for behavior problems.

High-Density Lipoprotein Cholesterol and Cause-Specific Mortality in Individuals Without Previous Cardiovascular Conditions: The CANHEART Study.

PubMed

Ko, Dennis T; Alter, David A; Guo, Helen; Koh, Maria; Lau, Geoffrey; Austin, Peter C; Booth, Gillian L; Hogg, William; Jackevicius, Cynthia A; Lee, Douglas S; Wijeysundera, Harindra C; Wilkins, John T; Tu, Jack V

2016-11-08

The prognostic importance of high-density lipoprotein cholesterol (HDL-C) as a specific risk factor for cardiovascular (CV) disease has been challenged by recent clinical trials and genetic studies. This study sought to reappraise the association of HDL-C level with CV and non-CV mortality using a "big data" approach. An observational cohort study was conducted using the CANHEART (Cardiovascular Health in Ambulatory Care Research Team) dataset, which was created by linking together 17 different individual-level data sources. People were included if they were between 40 and 105 years old on January 1, 2008, living in Ontario, Canada, without previous CV conditions or severe comorbidities, and had an outpatient fasting cholesterol measurement in the year prior to the inception date. The primary outcome was cause-specific mortality. A total of 631,762 individuals were included. The mean age of our cohort was 57.2 years, 55.4% were women, and mean HDL-C level was 55.2 mg/dl. There were 17,952 deaths during a mean follow-up of 4.9 ± 0.4 years. The overall all-cause mortality rate was 8.1 per 1,000 person-years for men and 6.6 per 1,000 person-years for women. Individuals with lower HDL-C levels were more likely to have low incomes, unhealthy lifestyle, higher triglycerides levels, other cardiac risk factors, and medical comorbidities. Individuals with lower HDL-C levels were independently associated with higher risk of CV, cancer, and other mortality compared with individuals in the reference ranges of HDL-C levels. In addition, individuals with higher HDL levels (>70 mg/dl in men, >90 mg/dl in women) had increased hazard of non-CV mortality. Complex associations exist between HDL-C levels and sociodemographic, lifestyle, comorbidity factors, and mortality. HDL-C level is unlikely to represent a CV-specific risk factor given similarities in its associations with non-CV outcomes. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Critical Success Factors of Internet Shopping: The Case of Japan

NASA Astrophysics Data System (ADS)

Atchariyachanvanich, Kanokwan; Okada, Hitoshi; Sonehara, Noboru

This paper presents the results from a study conducted on the effect of differing factors on a customer's attitude towards using Internet shopping in Japan. The research model used was an extended version of the consumers' acceptance of virtual stores model with the addition of a new factor, need specificity, and a grouping of critical success factors based on their customer-centric and website-centric viewpoints sources. It examines how differences in the individual characteristics of customers affect the actual use of Internet shopping. According to an online questionnaire filled out by 1,215 online customers used to conduct a multiple regression analysis and a structural equation modeling analysis, the participant's gender, education level, innovativeness, net-orientation, and need specificity, which are the factors for the customer-centric viewpoints, have a positive impact on the actual use of Internet shopping. The implication also shows that Japanese online customers do not worry about the quality of service of Internet shopping, a factor in the website-centric viewpoint, as significantly as offline customers do.

The Relationship between Brand-Specific Alcohol Advertising on Television and Brand-Specific Consumption among Underage Youth

PubMed Central

Ross, Craig S.; Maple, Emily; Siegel, Michael; DeJong, William; Naimi, Timothy S.; Ostroff, Joshua; Padon, Alisa A.; Borzekowski, Dina L.G.; Jernigan, David H.

2014-01-01

Background Being able to investigate the relationship between underage drinkers' preferences for particular brands and their exposure to advertising for those brands would represent a significant advance in alcohol marketing research. However, no previous national study has examined the relationship between underage youth exposure to brand-specific alcohol advertising and consumption of those brands. Methods We conducted a cross-sectional, internet-based survey of a national sample of 1,031 youths, ages 13-20, who had consumed at least one drink of alcohol in the past 30 days. We ascertained all alcohol brands consumed by respondents in the past 30 days. The main outcome measure was brand-specific consumption during the past 30 days, measured as a dichotomous variable. The main predictor variable was exposure to brand-specific alcohol advertising on television. The respondents reported which of 20 television shows popular with youth they had watched during the past 30 days. For each respondent, we calculated a standard measure of potential exposure to the brand-specific alcohol advertising that aired on those shows during the preceding 12 months, based on Nielsen (New York, NY) estimates of the youth audience for each show's telecasts. Results Compared to no brand-specific advertising exposure, any exposure was associated with an increased likelihood of brand-specific consumption (adjusted odds ratio 3.02; 95% confidence interval: 2.61-3.49) after controlling for several individual- and brand-level variables. When measured as a continuous variable, the relationship between advertising exposure and brand consumption was nonlinear, with a large association at lower levels of exposure and diminishing incremental effects as the level of exposure increased. Conclusions There is a robust relationship between youth's brand-specific exposure to alcohol advertising on television and their consumption of those same alcohol brands during the past 30 days. This study provides further evidence of a strong association between alcohol advertising and youth drinking behavior. PMID:24986257

The relationship between brand-specific alcohol advertising on television and brand-specific consumption among underage youth.

PubMed

Ross, Craig S; Maple, Emily; Siegel, Michael; DeJong, William; Naimi, Timothy S; Ostroff, Joshua; Padon, Alisa A; Borzekowski, Dina L G; Jernigan, David H

2014-08-01

Being able to investigate the relationship between underage drinkers' preferences for particular brands and their exposure to advertising for those brands would represent a significant advance in alcohol marketing research. However, no previous national study has examined the relationship between underage youth exposure to brand-specific alcohol advertising and consumption of those brands. We conducted a cross-sectional, Internet-based survey of a national sample of 1,031 youth, ages 13-20, who had consumed at least 1 drink of alcohol in the past 30 days. We ascertained all alcohol brands consumed by respondents in the past 30 days. The main outcome measure was brand-specific consumption during the past 30 days, measured as a dichotomous variable. The main predictor variable was exposure to brand-specific alcohol advertising on television. The respondents reported which of 20 television shows popular with youth they had watched during the past 30 days. For each respondent, we calculated a standard measure of potential exposure to the brand-specific alcohol advertising that aired on those shows during the preceding 12 months, based on Nielsen (New York, NY) estimates of the youth audience for each show's telecasts. Compared to no brand-specific advertising exposure, any exposure was associated with an increased likelihood of brand-specific consumption (adjusted odds ratio 3.02; 95% confidence interval: 2.61-3.49) after controlling for several individual- and brand-level variables. When measured as a continuous variable, the relationship between advertising exposure and brand consumption was nonlinear, with a large association at lower levels of exposure and diminishing incremental effects as the level of exposure increased. There is a robust relationship between youth's brand-specific exposure to alcohol advertising on television and their consumption of those same alcohol brands during the past 30 days. This study provides further evidence of a strong association between alcohol advertising and youth drinking behavior. Copyright © 2014 by the Research Society on Alcoholism.

Experimental studies for determining human discomfort response to vertical sinusoidal vibration

NASA Technical Reports Server (NTRS)

Dempsey, T. K.; Leatherwood, J. D.

1975-01-01

A study was conducted to investigate several problems related to methodology and design of experiments to obtain human comfort response to vertical sinusoidal vibration. Specifically, the studies were directed to the determination of (1) the adequacy of frequency averaging of vibration data to obtain discomfort predictors, (2) the effect of practice on subject ratings, (3) the effect of the demographic factors of age, sex, and weight, and (4) the relative importance of seat and floor vibrations in the determination of measurement and criteria specification location. Results indicate that accurate prediction of discomfort requires knowledge of both the acceleration level and frequency content of the vibration stimuli. More importantly, the prediction of discomfort was shown to be equally good based upon either floor accelerations or seat accelerations. Furthermore, it was demonstrated that the discomfort levels in different seats resulting from similar vibratory imputs were equal. Therefore, it was recommended that criteria specifications and acceleration measurements be made at the floor location. The results also indicated that practice did not systematically influence discomfort responses nor did the demographic factors of age, weight, and sex contribute to the discomfort response variation.

Psychophysiology of prospective memory.

PubMed

Rothen, Nicolas; Meier, Beat

2014-01-01

Prospective memory involves the self-initiated retrieval of an intention upon an appropriate retrieval cue. Cue identification can be considered as an orienting reaction and may thus trigger a psychophysiological response. Here we present two experiments in which skin conductance responses (SCRs) elicited by prospective memory cues were compared to SCRs elicited by aversive stimuli to test whether a single prospective memory cue triggers a similar SCR as an aversive stimulus. In Experiment 2 we also assessed whether cue specificity had a differential influence on prospective memory performance and on SCRs. We found that detecting a single prospective memory cue is as likely to elicit a SCR as an aversive stimulus. Missed prospective memory cues also elicited SCRs. On a behavioural level, specific intentions led to better prospective memory performance. However, on a psychophysiological level specificity had no influence. More generally, the results indicate reliable SCRs for prospective memory cues and point to psychophysiological measures as valuable approach, which offers a new way to study one-off prospective memory tasks. Moreover, the findings are consistent with a theory that posits multiple prospective memory retrieval stages.

A microfluidic device for real-time monitoring of Bacillus subtilis bacterial spores during germination based on non-specific physicochemical interactions on the nanoscale level.

PubMed

Zabrocka, L; Langer, K; Michalski, A; Kocik, J; Langer, J J

2015-01-07

A microfluidic device for studies on the germination of bacterial spores (e.g. Bacillus subtilis) based on non-specific interactions on the nanoscale is presented. A decrease in the population of spores during germination followed by the appearance of transition forms and an increase in the number of vegetative cells can be registered directly and simultaneously by using the microfluidic device, which is equipped with a conductive polymer layer (polyaniline) in the form of a nano-network. The lab-on-a-chip-type device, operating in a continuous flow regime, allows monitoring of germination of bacterial spores and analysis of the process in detail. The procedure is fast and accurate enough for quantitative real-time monitoring of the main steps of germination, including final transformation of the spores into vegetative cells. All of this is done without the use of biomarkers or any bio-specific materials, such as enzymes, antibodies and aptamers, and is simply based on an analysis of physicochemical interactions on the nanoscale level.

Surface- and Ground-Water Monitoring and Mapping of Selected Features at the Blue Ridge Parkway Mt. Pisgah Campground, Haywood County, North Carolina, 2002

USGS Publications Warehouse

Smith, Douglas G.

2004-01-01

During 2002, a baseline study of hydrologic conditions was conducted, and selected features were mapped within the Mt. Pisgah campground on the Blue Ridge Parkway in Haywood County, North Carolina. Field surveys were performed by using global positioning system equipment one time (January 2002) during the study to locate hydrologic and other types of features in the study area. Water-level and streamflow data and seasonal water-quality samples were collected from a stream that receives all surface-water drainage from the campground area. During 2002, water levels (stage) in the stream ranged from 1.09 to 1.89 feet above gage datum (4,838.06 to 4,838.86 feet above mean sea level). Flow in the stream ranged from 0.05 to 9.7 cubic feet per second. Annual daily mean flow for calendar year 2002 was approximately 0.35 cubic foot per second (about 226,000 gallons per day). Samples collected from the stream had low concentrations of all constituents measured. Four compounds associated with human activity (camphor, N,N-diethyl-meta-toluamide (the insect repellent DEET), tributylphosphate, and methylsalicylate) were detected in the stream samples; however, concentrations were less than detection levels. Stream samples collected in April and September and analyzed for fecal coliform bacteria had densities of 76 and 110 colonies per 100 milliliters of water, respectively. No violations of water-quality standards were noted for any constituent measured in the stream samples. Seven shallow ground-water wells were installed near a natural area in the center of the campground. Ground-water levels measured periodically in these wells and in two existing shallow piezometers generally were highest in the spring and lowest in the fall. Water temperature, pH, and specific conductance were measured in samples collected from the shallow wells in April and September 2002. Measured pH values were consistently lowest in samples from two wells on the west side of the natural area and highest in samples from the well located near the center of the natural area. Specific-conductance values measured in samples from wells on the east side of the natural area were lower than those measured in samples from the other wells. Specific-conductance values measured in samples from two wells on the west side and from one well near the center of the natural area generally were two to three times higher than the specific-conductance values measured in samples from wells on the east side of the natural area. Samples for fecal coliform bacteria were collected from six wells on September 11, 2002. The fecal coliform densities in samples from most of the wells were less than or equal to 8 colonies per 100 milliliters. Samples from two of the three wells on the west side of the natural area had coliform densities of 16 and 480 colonies per 100 milliliters. Other ground-water samples collected on September 11 and September 24 were analyzed with a spectrophotometer in the U.S. Geological Survey (USGS) North Carolina District Office for nitrate concentrations only. From the samples collected on September 11, estimated nitrate concentrations of 1 milligram per liter or less were detected in three wells, two on the west side and one on the east side of the natural area. Nitrate was not detected with a spectrophotometer in any of the ground-water samples collected on September 24. Indicator test strips also were used in the field to screen for nitrate and nitrite in ground-water samples collected on September 24. Nitrate was detected by test strips in one well on the west side of the natural area, with estimated concentrations of 1 milligram per liter or less indicated. Nitrite was not detected by the test strips in samples collected from any of the wells.

Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging

PubMed Central

Kyung, Eun Jung; Kim, Hyun Bum; Hwang, Eun Sang; Lee, Seok; Choi, Bup Kyung; Lim, Sang Moo; Kwon, Oh In

2018-01-01

In oriental medicine, curcumin is used to treat inflammatory diseases, and its anti-inflammatory effect has been reported in recent research. In this feasibility study, the hepatoprotective effect of curcumin was investigated using a rat liver cirrhosis model, which was induced with dimethylnitrosamine (DMN). Together with biochemical analysis, we used a magnetic resonance-based electrical conductivity imaging method to evaluate tissue conditions associated with a protective effect. The effects of curcumin treatment and lactulose treatment on liver cirrhosis were compared. Electrical conductivity images indicated that liver tissues damaged by DMN showed decreased conductivity compared with normal liver tissues. In contrast, cirrhotic liver tissues treated with curcumin or lactulose showed increased conductivity than tissues in the DMN-only group. Specifically, conductivity of cirrhotic liver after curcumin treatment was similar to that of normal liver tissues. Histological staining and immunohistochemical examination showed significant levels of attenuated fibrosis and decreased inflammatory response after both curcumin and lactulose treatments compared with damaged liver tissues by DMN. The conductivity imaging and biochemical examination results indicate that curcumin's anti-inflammatory effect can prevent the progression of irreversible liver dysfunction. PMID:29887757

Water quality of selected lakes in Mount Rainier National Park, Washington with respect to lake acidification

USGS Publications Warehouse

Turney, G.L.; Dion, N.P.; Sumioka, S.S.

1986-01-01

Thirteen lakes in Mount Rainier National Park were evaluated for general chemical characteristics, sensitivity to acidification by acidic precipitation, and degree of existing acidification. The lakes studies were Allen, one of the Chenuis group, Crescent , Crystal, Eleanor, Fan, one of the Golden group, Marsh, Mowich, Mystic, Shriner, and two unnamed lakes. The lakes were sampled in August 1983. Specific conductance values were generally 21 microsiemens/cm at 25 C or less, and dissolved solids concentrations were generally 20 mg/L or less. The major cations were calcium and sodium, and the major anion was bicarbonate. Alkalinity concentrations ranged from 2.1 to 9.0 mg/L in 12 of the lakes. Allen Lake was the exception, having an alkalinity concentration of 27 mg/L. The pH values for all of the lakes ranged from 5.8 to 6.5. In most of the lakes, vertical profiles of temperature, dissolved oxygen, pH, and specific conductance were relatively uniform. In the deeper lakes, temperature decreased with depth and dissolved-oxygen concentrations increased to about 20 feet, remained constant to 80 ft, then decreased with increasing depth. Exceptions to general water quality patterns were observed in three lakes. Allen Lake had a specific conductance value of 58 Microsiemens/cm. The lake of the Golden group was anaerobic at the bottom and had relatively high concentrations of dissolved organic carbon and dissolved metals, and a lower light transmission than the other lakes studied. One of the unnamed lakes had relatively high concentrations of phytoplankton and dissolved organic carbon and relatively low levels of light transmission. Comparisons of lake data to acid-sensitivity thresholds for specific conductance and alkalinity indicated that all of the lakes except Allen would be sensitive to acidic precipitation. The small sizes of the lakes, and their locations in basins of high precipitation and weathering-resistant rock types, enhance their sensitivity. None of the lakes in this study appeared to be presently acidified. (Lantz-PTT)

Finding Best Value in Two-Step Sealed Bidding

DTIC Science & Technology

1992-12-01

metric [Ref. 39: p. 34]. For example, a Mercedes Benz car might appear to have a higher net-value than a Ford Taurus; however, the total cost of owning a...Finally, the 1991 Defense Authorization Act required DOD to conduct market research prior to developing new specifications to determine if...at subsystem, component, and piece part levels in major developmental efforts [Ref. 15: p. 2-3]. There are many commercial market areas that are well

Dropout from individual psychotherapy for major depression: A meta-analysis of randomized clinical trials.

PubMed

Cooper, Andrew A; Conklin, Laren R

2015-08-01

Dropout from mental health treatment poses a substantial problem, but rates vary substantially across studies and diagnoses. Focused reviews are needed to provide more detailed estimates for specific areas of research. Randomized clinical trials involving individual psychotherapy for unipolar depression are ubiquitous and important, but empirical data on average dropout rates from these studies is lacking. We conducted a random-effects meta-analysis of 54 such studies (N=5852) including 80 psychotherapy conditions, and evaluated a number of predictors of treatment- and study-level dropout rates. Our overall weighted dropout estimates were 19.9% at the study level, and 17.5% for psychotherapy conditions specifically. Therapy orientation did not significantly account for variance in dropout estimates, but estimates were significantly higher in psychotherapy conditions with more patients of minority racial status or with comorbid personality disorders. Treatment duration was also positively associated with dropout rates at trend level. Studies with an inactive control comparison had higher dropout rates than those without such a condition. Limitations include the inability to test certain potential predictors (e.g., socioeconomic status) due to infrequent reporting. Overall, our findings suggest the need to consider how specific patient and study characteristics may influence dropout rates in clinical research on individual therapy for depression. Copyright © 2015 Elsevier Ltd. All rights reserved.

Perceived stress, depressive symptoms, and suicidal ideation in undergraduate women with varying levels of mindfulness.

PubMed

Anastasiades, Maria H; Kapoor, Shweta; Wootten, Jennifer; Lamis, Dorian A

2017-02-01

Research has demonstrated that perceived stress and depression are risk factors for suicidal ideation in young adults, particularly women attending college. Female undergraduate students (N = 928) were administered measures assessing their levels of stress, depressive symptoms, suicidal thoughts, and mindfulness. A moderated-mediation analysis was conducted to examine the complex associations among these variables. Results indicated that mindfulness moderated the mediated effect of depressive symptoms on perceived stress and suicidal ideation. Specifically, the indirect effect was stronger in college women with lower levels of mindfulness as compared to those students who reported higher mindfulness. Thus, teaching mindfulness techniques on college campuses may be an important strategy for preventing suicide, especially among young adult women experiencing stress and depressive symptoms.

Exploring alternate specifications to explain agency-level effects in placement decisions regarding aboriginal children: further analysis of the Canadian Incidence Study of Reported Child Abuse and Neglect Part B.

PubMed

Chabot, Martin; Fallon, Barbara; Tonmyr, Lil; MacLaurin, Bruce; Fluke, John; Blackstock, Cindy

2013-01-01

This paper builds upon the analyses presented in two companion papers (Fluke et al., 2010; Fallon et al., 2013) using data from the 1998 and 2003 cycles of the Canadian Incidence Study of Reported Child Abuse and Neglect (CIS-1998 and CIS-2003) to examine the influence of clinical and organizational characteristics on the decision to place a child in out-of-home care at the conclusion of a child maltreatment investigation. This paper explores various model specifications to explain the effect of an agency-level factor, proportion of Aboriginal reports, which emerged as a stable and significant factor through the two data collection cycles. It addresses the issue of data comparability between the two cycles and explores various re-specifications and descriptive analyses of reported models to evaluate their solidity with regards to the sampling schemes and the precise contribution of a multi-level specification. The decision to place a child in out-of-home care was examined using data from the CIS-2003. This child welfare dataset collected information about the results of nearly 12,000 child maltreatment investigations as well as a description of the characteristics of the workers and organization responsible for conducting those investigations. Multi-level statistical models were developed using MPlus software, which can accommodate dichotomous outcome variables and are more reflective of decision-making in child welfare. The models are thus multi-level binary logistic regressions. Final models revealed that two agency-level variables, 'Education degree of majority of workers' and 'Degree of centralization in the agency' clarify the nature of the effect of 'Proportion of Aboriginal reports', a stable, key second level predictor of the placement decision. The comparability of the effect of this agency-level variable across the 1998 and 2003 cycles becomes further evident through this analysis. By using a unified database including both cycles and various specifications of models, the comparability was found to be robust, in addition to clarifying the precise contribution of a multi-level specification. This third paper in a series establishes the 'Proportion of Aboriginal reports' received by the child welfare agency as an important agency level predictor associated with a child's likelihood of being placed in the Canadian child protection system. While the more complex models give support to the notion that unequal resources subtend those results, more analyses are needed to confirm this hypothesis. Unequal resources for agencies with larger Aboriginal caseloads may explain the persistence of the results. These findings suggest that specific resource constraints related to worker education may be explanatory. Copyright © 2012 Elsevier Ltd. All rights reserved.

Development and Validation of the Pediatric Medical Complexity Algorithm (PMCA) Version 3.0.

PubMed

Simon, Tamara D; Haaland, Wren; Hawley, Katherine; Lambka, Karen; Mangione-Smith, Rita

2018-02-26

To modify the Pediatric Medical Complexity Algorithm (PMCA) to include both International Classification of Diseases, Ninth and Tenth Revisions, Clinical Modification (ICD-9/10-CM) codes for classifying children with chronic disease (CD) by level of medical complexity and to assess the sensitivity and specificity of the new PMCA version 3.0 for correctly identifying level of medical complexity. To create version 3.0, PMCA version 2.0 was modified to include ICD-10-CM codes. We applied PMCA version 3.0 to Seattle Children's Hospital data for children with ≥1 emergency department (ED), day surgery, and/or inpatient encounter from January 1, 2016, to June 30, 2017. Starting with the encounter date, up to 3 years of retrospective discharge data were used to classify children as having complex chronic disease (C-CD), noncomplex chronic disease (NC-CD), and no CD. We then selected a random sample of 300 children (100 per CD group). Blinded medical record review was conducted to ascertain the levels of medical complexity for these 300 children. The sensitivity and specificity of PMCA version 3.0 was assessed. PMCA version 3.0 identified children with C-CD with 86% sensitivity and 86% specificity, children with NC-CD with 65% sensitivity and 84% specificity, and children without CD with 77% sensitivity and 93% specificity. PMCA version 3.0 is an updated publicly available algorithm that identifies children with C-CD, who have accessed tertiary hospital emergency department, day surgery, or inpatient care, with very good sensitivity and specificity when applied to hospital discharge data and with performance to earlier versions of PMCA. Copyright © 2018 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

Autism-specific covariation in perceptual performances: "g" or "p" factor?

PubMed

Meilleur, Andrée-Anne S; Berthiaume, Claude; Bertone, Armando; Mottron, Laurent

2014-01-01

Autistic perception is characterized by atypical and sometimes exceptional performance in several low- (e.g., discrimination) and mid-level (e.g., pattern matching) tasks in both visual and auditory domains. A factor that specifically affects perceptive abilities in autistic individuals should manifest as an autism-specific association between perceptual tasks. The first purpose of this study was to explore how perceptual performances are associated within or across processing levels and/or modalities. The second purpose was to determine if general intelligence, the major factor that accounts for covariation in task performances in non-autistic individuals, equally controls perceptual abilities in autistic individuals. We asked 46 autistic individuals and 46 typically developing controls to perform four tasks measuring low- or mid-level visual or auditory processing. Intelligence was measured with the Wechsler's Intelligence Scale (FSIQ) and Raven Progressive Matrices (RPM). We conducted linear regression models to compare task performances between groups and patterns of covariation between tasks. The addition of either Wechsler's FSIQ or RPM in the regression models controlled for the effects of intelligence. In typically developing individuals, most perceptual tasks were associated with intelligence measured either by RPM or Wechsler FSIQ. The residual covariation between unimodal tasks, i.e. covariation not explained by intelligence, could be explained by a modality-specific factor. In the autistic group, residual covariation revealed the presence of a plurimodal factor specific to autism. Autistic individuals show exceptional performance in some perceptual tasks. Here, we demonstrate the existence of specific, plurimodal covariation that does not dependent on general intelligence (or "g" factor). Instead, this residual covariation is accounted for by a common perceptual process (or "p" factor), which may drive perceptual abilities differently in autistic and non-autistic individuals.

Autism-Specific Covariation in Perceptual Performances: “g” or “p” Factor?

PubMed Central

Meilleur, Andrée-Anne S.; Berthiaume, Claude; Bertone, Armando; Mottron, Laurent

2014-01-01

Background Autistic perception is characterized by atypical and sometimes exceptional performance in several low- (e.g., discrimination) and mid-level (e.g., pattern matching) tasks in both visual and auditory domains. A factor that specifically affects perceptive abilities in autistic individuals should manifest as an autism-specific association between perceptual tasks. The first purpose of this study was to explore how perceptual performances are associated within or across processing levels and/or modalities. The second purpose was to determine if general intelligence, the major factor that accounts for covariation in task performances in non-autistic individuals, equally controls perceptual abilities in autistic individuals. Methods We asked 46 autistic individuals and 46 typically developing controls to perform four tasks measuring low- or mid-level visual or auditory processing. Intelligence was measured with the Wechsler's Intelligence Scale (FSIQ) and Raven Progressive Matrices (RPM). We conducted linear regression models to compare task performances between groups and patterns of covariation between tasks. The addition of either Wechsler's FSIQ or RPM in the regression models controlled for the effects of intelligence. Results In typically developing individuals, most perceptual tasks were associated with intelligence measured either by RPM or Wechsler FSIQ. The residual covariation between unimodal tasks, i.e. covariation not explained by intelligence, could be explained by a modality-specific factor. In the autistic group, residual covariation revealed the presence of a plurimodal factor specific to autism. Conclusions Autistic individuals show exceptional performance in some perceptual tasks. Here, we demonstrate the existence of specific, plurimodal covariation that does not dependent on general intelligence (or “g” factor). Instead, this residual covariation is accounted for by a common perceptual process (or “p” factor), which may drive perceptual abilities differently in autistic and non-autistic individuals. PMID:25117450

Are patients comprehending? A critical assessment of online patient educational materials.

PubMed

Bui, Thanh-Lan; Silva-Hirschberg, Catalina; Torres, Josefina; Armstrong, April W

2018-05-01

The primary aim of this study was to evaluate the readability, understandability, suitability and actionability of online psoriasis patient educational materials. A secondary aim was to identify areas for improvement. We conducted an evaluation study to assess online psoriasis patient educational materials from the American Academy of Dermatology and National Psoriasis Foundation available in July 2017. We used two validated assessment tools specific to online healthcare materials. Outcomes were expressed as percentages, where higher percentages corresponded to higher quality materials. Overall, the educational materials had a mean understandability score (72.7%) that was understandable; a suitability score (58.8%) that was adequate; a reading grade level (10.5) that was not readable; and an actionability score (54.7%) that was not actionable. Areas of improvement include reading grade level, visual aids, word choice, specific steps for actions and cultural appropriateness. Online psoriasis patient educational materials are understandable and suitable, but they are written above the American Medical Association and National Institutes of Health's recommended 6th-8th grade reading level and are not actionable. Materials can benefit from decreasing reading grade level, including more visual elements, incorporating more actionable items and being culturally inclusive.

A typology of household-level adaptation to coastal flooding and its spatio-temporal patterns.

PubMed

Koerth, Jana; Vafeidis, Athanasios T; Carretero, Silvina; Sterr, Horst; Hinkel, Jochen

2014-01-01

The predicted sea-level rise and changes in storm surge regimes are expected to lead to an increasing risk of flooding in coastal regions. Accommodation can be an alternative to protection in many areas, with household-level adaptation potentially constituting an important element of such a strategy, as it can significantly reduce costs. To date, a systematic typology of household-level adaptation to coastal flooding does not exist. In order to bridge this gap, we conducted a series of quantitative surveys in different coastal areas in Denmark, Germany and Argentina. We applied a cluster analysis in order to categorise the adaptive behaviour of coastal households. Coastal households were found to cluster in four groups that we term: the comprehensives, the theoreticians, the minimalists and the structurals. With the exception of households focusing on the implementation of high-effort structural measures, our results show the affiliation to these groups to follow a specific temporal sequence. At the same time, large differences in category affiliation exist between the study areas. Risk communication tools can utilise our typology to selectively target specific types of households or to ensure that the information needs of all groups are addressed.

Branch age and light conditions determine leaf-area-specific conductivity in current shoots of Scots pine.

PubMed

Grönlund, Leila; Hölttä, Teemu; Mäkelä, Annikki

2016-08-01

Shoot size and other shoot properties more or less follow the availability of light, but there is also evidence that the topological position in a tree crown has an influence on shoot development. Whether the hydraulic properties of new shoots are more regulated by the light or the position affects the shoot acclimation to changing light conditions and thereby to changing evaporative demand. We investigated the leaf-area-specific conductivity (and its components sapwood-specific conductivity and Huber value) of the current-year shoots of Scots pine (Pinus sylvestris L.) in relation to light environment and topological position in three different tree classes. The light environment was quantified in terms of simulated transpiration and the topological position was quantified by parent branch age. Sample shoot measurements included length, basal and tip diameter, hydraulic conductivity of the shoot, tracheid area and density, and specific leaf area. In our results, the leaf-area-specific conductivity of new shoots declined with parent branch age and increased with simulated transpiration rate of the shoot. The relation to transpiration demand seemed more decisive, since it gave higher R(2) values than branch age and explained the differences between the tree classes. The trend of leaf-area-specific conductivity with simulated transpiration was closely related to Huber value, whereas the trend of leaf-area-specific conductivity with parent branch age was related to a similar trend in sapwood-specific conductivity. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Patterns of Childhood Abuse and Neglect in a Representative German Population Sample

PubMed Central

Schilling, Christoph; Weidner, Kerstin; Brähler, Elmar; Glaesmer, Heide; Häuser, Winfried; Pöhlmann, Karin

2016-01-01

Background Different types of childhood maltreatment, like emotional abuse, emotional neglect, physical abuse, physical neglect and sexual abuse are interrelated because of their co-occurrence. Different patterns of childhood abuse and neglect are associated with the degree of severity of mental disorders in adulthood. The purpose of this study was (a) to identify different patterns of childhood maltreatment in a representative German community sample, (b) to replicate the patterns of childhood neglect and abuse recently found in a clinical German sample, (c) to examine whether participants reporting exposure to specific patterns of child maltreatment would report different levels of psychological distress, and (d) to compare the results of the typological approach and the results of a cumulative risk model based on our data set. Methods In a cross-sectional survey conducted in 2010, a representative random sample of 2504 German participants aged between 14 and 92 years completed the Childhood Trauma Questionnaire (CTQ). General anxiety and depression were assessed by standardized questionnaires (GAD-2, PHQ-2). Cluster analysis was conducted with the CTQ-subscales to identify different patterns of childhood maltreatment. Results Three different patterns of childhood abuse and neglect could be identified by cluster analysis. Cluster one showed low values on all CTQ-scales. Cluster two showed high values in emotional and physical neglect. Only cluster three showed high values in physical and sexual abuse. The three patterns of childhood maltreatment showed different degrees of depression (PHQ-2) and anxiety (GAD-2). Cluster one showed lowest levels of psychological distress, cluster three showed highest levels of mental distress. Conclusion The results show that different types of childhood maltreatment are interrelated and can be grouped into specific patterns of childhood abuse and neglect, which are associated with differing severity of psychological distress in adulthood. The results correspond to those recently found in a German clinical sample and support a typological approach in the research of maltreatment. While cumulative risk models focus on the number of maltreatment types, the typological approach takes the number as well as the severity of the maltreatment types into account. Thus, specific patterns of maltreatment can be examined with regard to specific long-term psychological consequences. PMID:27442446

Cadmium, lead, and chromium in large game: a local-scale exposure assessment for hunters consuming meat and liver of wild boar.

PubMed

Danieli, P P; Serrani, F; Primi, R; Ponzetta, M P; Ronchi, B; Amici, A

2012-11-01

Heavy metals are ubiquitous in soil, water, and air. Their entrance into the food chain is an important environmental issue that entails risks to humans. Several reports indicate that game meat can be an important source of heavy metals, particularly because of the increasing consumption of game meat, mainly by hunters. We performed an exposure assessment of hunters and members of their households, both adults and children, who consumed wild boar (WB) meat and offal. We estimated the amount of cadmium, lead, and chromium in the tissues of WB hunted in six areas within Viterbo Province (Italy) and gathered data on WB meat and offal consumption by conducting specific diet surveys in the same areas. The exposure to cadmium, lead, and chromium was simulated with specifically developed Monte Carlo simulation models. Cadmium and lead levels in WB liver and meat harvested in Viterbo Province (Italy) were similar to or lower than the values reported in other studies. However, some samples contained these metals at levels greater then the EU limits set for domestic animals. The chromium content of meat or liver cannot be evaluated against any regulatory limit, but our results suggest that the amounts of this metal found in WB products may reflect a moderate environmental load. Our survey of the hunter population confirmed that their consumption of WB meat and liver was greater than that of the general Italian population. This level of consumption was comparable with other European studies. Consumption of WB products contributes significantly to cadmium and lead exposure of both adults and children. More specifically, consumption of the WB liver contributed significantly to total cadmium and lead exposure of members of the households of WB hunters. As a general rule, liver consumption should be kept to a minimum, especially for children living in these hunter households. The exposure to chromium estimated for this population of hunters may be considered to be safe. However, a specific and complete assessment of chromium speciation in relevant dietary and environmental situations should be conducted.

Structured Multi-level Data Fusion and Modelling of Heterogeneous Environmental Data for Future Internet Applications

NASA Astrophysics Data System (ADS)

Sabeur, Zoheir; Chakravarthy, Ajay; Bashevoy, Maxim; Modafferi, Stefano

2013-04-01

The rapid increase in environmental observations which are conducted by Small to Medium Enterprise communities and volunteers using affordable in situ sensors at various scales, in addition to the more established observatories set up by environmental and space agencies using airborne and space-borne sensing technologies is generating serious amounts of BIG data at ever increasing speeds. Furthermore, the emergence of Future Internet technologies and the urgent requirements for the deployment of specific enablers for the delivery of processed environmental knowledge in real-time with advanced situation awareness to citizens has reached paramount importance. Specifically, it has become highly critical now to build and provide services which automate the aggregation of data from various sources, while surmounting the semantic gaps, conflicts and heterogeneity in data sources. The early stage aggregation of data will enable the pre-processing of data from multiple sources while reconciling the temporal gaps in measurement time series, and aligning their respective a-synchronicities. This low level type of data fusion process needs to be automated and chained to more advanced level of data fusion services specialising in observation forecasts at spaces where sensing is not deployed; or at time slices where sensing has not taken place yet. As a result, multi-level fusion services are required among the families of specific enablers for monitoring environments and spaces in the Future Internet. These have been intially deployed and piloted in the ongoing ENVIROFI project of the FI-PPP programme [1]. Automated fusion and modelling of in situ and remote sensing data has been set up and the experimentation successfully conducted using RBF networks for the spatial fusion of water quality parameters measurements from satellite and stationary buoys in the Irish Sea. The RBF networks method scales for the spatial data fusion of multiple types of observation sources. This important approach provides a strong basis for the delivery of environmental observations at desired spatial and temporal scales to multiple users with various needs of spatial and temporal resolutions. It has also led to building robust future internet specific enablers on data fusion, which can indeed be used for multiple usage areas above and beyond the environmental domains of the Future Internet. In this paper, data and processing workflow scenarios shall be described. The fucntionalities of the multi-level fusion services shall be demonstrated and made accessible to the wider communities of the Fututre Internet. [1] The Environmental Observation Web and its Service Applications within the Future Internet. ENVIROFI IP. FP7-2011-ICT-IF Pr.No: 284898 http://www.envirofi.eu/

Hydrologic and micrometeorologic data from an unsaturated zone study at a low-level radioactive waste burial site near Barnwell, South Carolina

USGS Publications Warehouse

Dennehy, K.F.; McMahon, P.B.

1985-01-01

Two years of selected hydrologic and micrometeorologic data collected at a low-level radioactive waste burial site near Barnwell, South Carolina are available on magnetic tape in card-image format. Hydrologic data include daily measurements of soil-moisture tension, soil-moisture specific conductance, and soil temperature at four monitoring site locations. Micrometeorlogic data include hourly measurements for the following parameters: dry- and wet-bulb temperatures, soil temperatures, soil heat flux, wind speeds and direction, incoming and reflected short-wave solar radiation, incoming and emitted long-wave radiation, net radiation and precipitation. (USGS)

Collaboration management framework for OEM - suppliers relationships: a trust-based conceptual approach

NASA Astrophysics Data System (ADS)

Belkadi, Farouk; Messaadia, Mourad; Bernard, Alain; Baudry, David

2017-08-01

Due to the increased competitiveness and the diversity of requirements in today's markets, manufacturing companies need to join their competencies and resources to propose innovative solutions for each specific market, with the possibility to transpose these solutions to another market, by means of slight adaptations. Thus, manufacturing firms must constantly conduct new collaborations with known partners in most cases, but also with new partners. The critical question for managers in this latter case is how to define the best collaborative strategy according to the goals of the project and the specificity of the target market. This paper tackles the problem by proposing a conceptual framework for supporting the management of collaborative situations in the case of Original equipment manufacturers (OEMs). Based on the concept of trust level, the framework proposes a classification of different collaboration modes to be adopted in various contexts of inter-enterprise relationships, in manufacturing sector. The aim is to support the flexible navigation between different collaborative situations by taking into account all decision-making levels from the strategy to the implementation of the information technologies (IT) systems at the operational level.

State Firearm Laws, Firearm Ownership, and Safety Practices Among Families of Preschool-Aged Children

PubMed Central

Martin-Storey, Alexa; Crosnoe, Robert

2014-01-01

Objectives. We investigated how state-level firearms legislation is associated with firearm ownership and storage among families with preschool-aged children. Methods. Using 2005 nationally representative data from the Early Childhood Longitudinal Study-Birth Cohort (n = 8100), we conducted multinomial regression models to examine the associations between state-level firearms legislation generally, child access prevention (CAP) firearms legislation specifically, and parental firearm ownership and storage safety practices. Results. Overall, 8% of families with children aged 4 years living in states with stronger firearm laws and CAP laws owned firearms compared with 24% of families in states with weaker firearm laws and no CAP laws. Storage behaviors of firearm owners differed minimally across legislative contexts. When we controlled for family- and state-level characteristics, we found that firearm legislation and CAP laws interacted to predict ownership and storage behaviors, with unsafe storage least likely among families in states with both CAP laws and stronger firearm legislation. Conclusions. Broader firearm legislation is linked with the efficacy of child-specific legislation in promoting responsible firearm ownership. PMID:24825210

Neural control of the kidney: functionally specific renal sympathetic nerve fibers.

PubMed

DiBona, G F

2000-11-01

The sympathetic nervous system provides differentiated regulation of the functions of various organs. This differentiated regulation occurs via mechanisms that operate at multiple sites within the classic reflex arc: peripherally at the level of afferent input stimuli to various reflex pathways, centrally at the level of interconnections between various central neuron pools, and peripherally at the level of efferent fibers targeted to various effectors within the organ. In the kidney, increased renal sympathetic nerve activity regulates the functions of the intrarenal effectors: the tubules, the blood vessels, and the juxtaglomerular granular cells. This enables a physiologically appropriate coordination between the circulatory, filtration, reabsorptive, excretory, and renin secretory contributions to overall renal function. Anatomically, each of these effectors has a dual pattern of innervation consisting of a specific and selective innervation by unmyelinated slowly conducting C-type renal sympathetic nerve fibers in addition to an innervation that is shared among all the effectors. This arrangement permits the maximum flexibility in the coordination of physiologically appropriate responses of the tubules, the blood vessels, and the juxtaglomerular granular cells to a variety of homeostatic requirements.

Functionally specific renal sympathetic nerve fibers: role in cardiovascular regulation.

PubMed

DiBona, G F

2001-06-01

The sympathetic nervous system provides differentiated regulation of the functions of various organs. This differentiated regulation occurs through mechanisms that operate at multiple sites within the classic reflex arc: peripherally at the level of afferent input stimuli to various reflex pathways, centrally at the level of interconnections between various central neuron pools, and peripherally at the level of efferent fibers targeted to various effectors within the organ. In the kidney, increased renal sympathetic nerve activity regulates the functions of the intrarenal effectors: the tubules, the blood vessels, and the juxtaglomerular granular cells. This enables a physiologically appropriate coordination between the circulatory, filtration, reabsorptive, excretory, and renin secretory contributions to overall renal function. Anatomically, each of these effectors has a dual pattern of innervation consisting of a specific and selective innervation by unmyelinated slowly conducting C-type renal sympathetic nerve fibers and an innervation that is shared among all the effectors. This arrangement facilitates maximum flexibility in the coordination of the tubules, the blood vessels, and the juxtaglomerular granular cells so as to produce physiologically appropriate responses to a variety of homeostatic requirements.

Nevada National Security Site 2014 Data Report: Groundwater Monitoring Program Area 5 Radioactive Waste Management Site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hudson, David

2015-02-01

This report is a compilation of the groundwater sampling results from the Area 5 Radioactive Waste Management Site (RWMS) at the Nevada National Security Site, Nye County, Nevada. Groundwater samples from the aquifer immediately below the Area 5 RWMS have been collected and analyzed and static water levels have been measured in this aquifer since 1993. This report updates these data to include the 2014 results. Analysis results for leachate contaminants collected from the mixed-waste cell at the Area 5 RWMS (Cell 18) are also included. During 2014, groundwater samples were collected and static water levels were measured at threemore » wells surrounding the Area 5 RWMS. Groundwater samples were collected at wells UE5PW-1, UE5PW-2, and UE5PW-3 on March 11 and August 12, 2014, and static water levels were measured at each of these wells on March 10, June 2, August 11, and October 14, 2014. Groundwater samples were analyzed for the following indicators of contamination: pH, specific conductance, total organic carbon, total organic halides, and tritium. General water chemistry (cations and anions) was also measured. Results from samples collected in 2014 are within the limits established by agreement with the Nevada Division of Environmental Protection for each analyte. The data from the shallow aquifer indicate that there has been no measurable impact to the uppermost aquifer from the Area 5 RWMS, and there were no significant changes in measured groundwater parameters compared to previous years. Leachate from above the primary liner of Cell 18 drains into a sump and is collected in a tank at the ground surface. Cell 18 began receiving waste in January 2011. Samples were collected from the tank when the leachate volume approached the 3,000-gallon tank capacity. Leachate samples have been collected 16 times since January 2011. During 2014, samples were collected on February 25, March 5, May 20, August 12, September 16, November 11, and December 16. Each leachate sample was analyzed for toxicity characteristic contaminants and polychlorinated biphenyls (PCB). Beginning with the sample from July 31, 2013, pH and specific conductance were also measured. Leachate analysis results show no evidence of contamination. Results for toxicity characteristic contaminants are all below regulatory levels and analysis quantification limits. No quantifiable PCB levels were detected in any sample. Results for pH and specific conductance are also within expected ranges. After analysis, leachate was pumped from the collection tank and used in Cell 18 for dust control. The report contains an updated cumulative chronology for the Area 5 RWMS Groundwater Monitoring Program and a brief description of the site hydrogeology.« less

Yeast cytochrome c integrated with electronic elements: a nanoscopic and spectroscopic study down to single-molecule level

NASA Astrophysics Data System (ADS)

Delfino, I.; Bonanni, B.; Andolfi, L.; Baldacchini, C.; Bizzarri, A. R.; Cannistraro, S.

2007-06-01

Various aspects of redox protein integration with nano-electronic elements are addressed by a multi-technique investigation of different yeast cytochrome c (YCC)-based hybrid systems. Three different immobilization strategies on gold via organic linkers are explored, involving either covalent bonding or electrostatic interaction. Specifically, Au surfaces are chemically modified by self-assembled monolayers (SAMs) exposing thiol-reactive groups, or by acid-oxidized single-wall carbon nanotubes (SWNTs). Atomic force microscopy and scanning tunnelling microscopy are employed to characterize the morphology and the electronic properties of single YCC molecules adsorbed on the modified gold surfaces. In each hybrid system, the protein molecules are stably assembled, in a native configuration. A standing-up arrangement of YCC on SAMs is suggested, together with an enhancement of the molecular conduction, as compared to YCC directly assembled on gold. The electrostatic interaction with functionalized SWNTs allows several YCC adsorption geometries, with a preferential high-spin haem configuration, as outlined by Raman spectroscopy. Moreover, the conduction properties of YCC, explored in different YCC nanojunctions by conductive atomic force microscopy, indicate the effectiveness of electrical conduction through the molecule and its dependence on the electrode material. The joint employment of several techniques confirms the key role of a well-designed immobilization strategy, for optimizing biorecognition capabilities and electrical coupling with conductive substrates at the single-molecule level, as a starting point for advanced applications in nano-biotechnology.

The Application of EM38: Determination of Soil Parameters, Selection of Soil Sampling Points and Use in Agriculture and Archaeology

PubMed Central

Heil, Kurt

2017-01-01

Fast and accurate assessment of within-field variation is essential for detecting field-wide heterogeneity and contributing to improvements in the management of agricultural lands. The goal of this paper is to provide an overview of field scale characterization by electromagnetic induction, firstly with a focus on the applications of EM38 to salinity, soil texture, water content and soil water turnover, soil types and boundaries, nutrients and N-turnover and soil sampling designs. Furthermore, results concerning special applications in agriculture, horticulture and archaeology are included. In addition to these investigations, this survey also presents a wide range of practical methods for use. Secondly, the effectiveness of conductivity readings for a specific target in a specific locality is determined by the intensity at which soil factors influence these values in relationship to the desired information. The interpretation and utility of apparent electrical conductivity (ECa) readings are highly location- and soil-specific, so soil properties influencing the measurement of ECa must be clearly understood. From the various calibration results, it appears that regression constants for the relationships between ECa, electrical conductivity of aqueous soil extracts (ECe), texture, yield, etc., are not necessarily transferable from one region to another. The modelling of ECa, soil properties, climate and yield are important for identifying the location to which specific utilizations of ECa technology (e.g., ECa−texture relationships) can be appropriately applied. In general, the determination of absolute levels of ECa is frequently not possible, but it appears to be quite a robust method to detect relative differences, both spatially and temporally. Often, the use of ECa is restricted to its application as a covariate or the use of the readings in a relative sense rather than as absolute terms. PMID:29113048

Electroactive biodegradable polyurethane significantly enhanced Schwann cells myelin gene expression and neurotrophin secretion for peripheral nerve tissue engineering.

PubMed

Wu, Yaobin; Wang, Ling; Guo, Baolin; Shao, Yongpin; Ma, Peter X

2016-05-01

Myelination of Schwann cells (SCs) is critical for the success of peripheral nerve regeneration, and biomaterials that can promote SCs' neurotrophin secretion as scaffolds are beneficial for nerve repair. Here we present a biomaterials-approach, specifically, a highly tunable conductive biodegradable flexible polyurethane by polycondensation of poly(glycerol sebacate) and aniline pentamer, to significantly enhance SCs' myelin gene expression and neurotrophin secretion for peripheral nerve tissue engineering. SCs are cultured on these conductive polymer films, and the biocompatibility of these films and their ability to enhance myelin gene expressions and sustained neurotrophin secretion are successfully demonstrated. The mechanism of SCs' neurotrophin secretion on conductive films is demonstrated by investigating the relationship between intracellular Ca(2+) level and SCs' myelination. Furthermore, the neurite growth and elongation of PC12 cells are induced by adding the neurotrophin medium suspension produced from SCs-laden conductive films. These data suggest that these conductive degradable polyurethanes that enhance SCs' myelin gene expressions and sustained neurotrophin secretion perform great potential for nerve regeneration applications. Copyright © 2016 Elsevier Ltd. All rights reserved.

Media campaign effectiveness in promoting a smoking-cessation program.

PubMed

Czarnecki, Karen Davis; Vichinsky, Laura E; Ellis, Jennifer A; Perl, Sarah B

2010-03-01

Little is known about the perceived barriers among smokers who do not utilize phone-based, population-level smoking-cessation services. The purpose of this study was to improve understanding of a media campaign's impact in promoting a phone-based, time-limited smoking-cessation program as measured by smoker awareness of the program, untapped interest in the program, perceived barriers to use of the program, and suggested methods for enhanced outreach. A random telephone survey of New York City smokers (n=1000) was conducted in 2006 in order to assess awareness of, interest in, and barriers to using the 2006 Nicotine Patch Program. Analyses were conducted in 2006 and 2007. The level of program awareness was high (60% overall), although it varied by demographic subgroup. The level of program interest among smokers unaware of the program was also encouragingly high (54%). Analysis of barriers to program use indicates that enrollment may be increased by addressing hesitance about using patches, developing messages for smokers who do not self-identify as smokers, and clarifying application procedures. Specific outreach strategies suggested by smokers include promotion through direct mail and advertising on public transportation. These data suggest that the use of mass media is an effective method for informing smokers about cessation services and that enrollment could be improved by modifying public messages to address barriers as well as expanding outreach to specific demographic groups. Improved outreach to smokers may be feasible using the strategies suggested by smokers in this survey. These findings can aid smoking-cessation services in expanding their reach and impact. Published by Elsevier Inc.

The effect of increasing doses of saw palmetto fruit extract on serum prostate specific antigen: analysis of the CAMUS randomized trial.

PubMed

Andriole, Gerald L; McCullum-Hill, Christie; Sandhu, Gurdarshan S; Crawford, E David; Barry, Michael J; Cantor, Alan

2013-02-01

Saw palmetto extracts are used to treat lower urinary tract symptoms in men despite level I evidence that saw palmetto is ineffective in reducing these lower urinary tract symptoms. We determined whether higher doses of saw palmetto as studied in the CAMUS (Complementary and Alternative Medicine for Urologic Symptoms) trial affect serum prostate specific antigen levels. The CAMUS trial was a randomized, placebo controlled, double-blind, multicenter, North American trial conducted between June 5, 2008 and October 10, 2012, in which 369 men older than 45 years with an AUA symptom score of 8 to 24 were randomly assigned to placebo or dose escalation of saw palmetto, which consisted of 320 mg for the first 24 weeks, 640 mg for the next 24 weeks and 960 mg for the last 24 weeks of this 72-week trial. Serum prostate specific antigen levels were obtained at baseline and at weeks 24, 48 and 72, and were compared between treatment groups using the pooled t test and Fisher's exact test. Serum prostate specific antigen was similar at baseline for the placebo (mean ± SD 1.93 ± 1.59 ng/ml) and saw palmetto groups (2.20 ± 1.95, p = 0.16). Changes in prostate specific antigen during the study were similar, with a mean change in the placebo group of 0.16 ± 1.08 ng/ml and 0.23 ± 0.83 ng/ml in the saw palmetto group (p = 0.50). In addition, no differential effect on serum prostate specific antigen was observed between treatment arms when the groups were stratified by baseline prostate specific antigen. Saw palmetto extract does not affect serum prostate specific antigen more than placebo, even at relatively high doses. Copyright © 2013 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Is Oral Food Challenge (OFC) test safe for preschool children?

PubMed

Karaman, Sait; Bahçeci, Semiha Erdem; Nacaroğlu, Hikmet Tekin; Karaman, Canan Şule; Can, Demet

2017-12-01

Oral food challenges (OFCs) are performed for diagnosis of a food allergy in cases where the allergy is not supported by patient history, or when a newly developed tolerance level needs to be established. We aimed to investigate the prevalence and severity of reactions during OFCs in preschool children. A retrospective study was conducted on children younger than 5 years, for whom OFC had been performed with milk, egg white and egg yolk. All children had been admitted to the Department of Pediatric Allergy at Behçet Uz Children's Hospital between 1 January 2010 and 31 December 2014. Any symptoms developed during the OFC were classified and recorded. A total of 122 patients who underwent an OFC were included in this study. The patients included 85 males (69.7%), and 50.8% of patients (n = 62) had a history of IgE-mediated food allergy. Co-existing allergies were found for 57.4% (n = 70) of patients. Of the OFCs performed, tests for milk, egg white and egg yolk made up 46.5, 30.5 and 23.0%, respectively. Of these, 19% (n = 33) were mild and 4.5% (n = 7) were moderate allergies in terms of symptom development. It was determined that the skin prick test (SPT) wheal size and the food-specific IgE levels did not effect in determining whether the allergic reaction would develop by OFC if the SPT wheal size and the food-specific IgE levels were below the cut-off point of a 95% positive predictive value (p > 0.05). The severity of egg and milk allergy symptoms resulting from the frequently used OFC in preschool children are generally mild and easy to manage, particularly if the OFC is only conducted if serum-specific IgE or SPT wheal size is below the cut-off point.

Prospective Relations between Family Conflict and Adolescent Maladjustment: Security in the Family System as a Mediating Process

PubMed Central

Cummings, E. Mark; Koss, Kalsea J.; Davies, Patrick T.

2018-01-01

Conflict in specific family systems (e.g., interparental, parent-child) has been implicated in the development of a host of adjustment problems in adolescence, but little is known about the impact of family conflict involving multiple family systems. Furthermore, questions remain about the effects of family conflict on symptoms of specific disorders and adjustment problems and the processes mediating these effects. The present study prospectively examines the impact of family conflict and emotional security about the family system on adolescent symptoms of specific disorders and adjustment problems, including the development of symptoms of anxiety, depression, conduct problems, and peer problems. Security in the family system was examined as a mediator of these relations. Participants included 295 mother-father-adolescent families (149 girls) participating across three annual time points (grades 7–9). Including auto-regressive controls for initial levels of emotional insecurity and multiple adjustment problems (T1), higher-order emotional insecurity about the family system (T2) mediated relations between T1 family conflict and T3 peer problems, anxiety, and depressive symptoms. Further analyses supported specific patterns of emotional security/insecurity (i.e., security, disengagement, preoccupation) as mediators between family conflict and specific domains of adolescent adjustment. Family conflict was thus found to prospectively predict the development of symptoms of multiple specific adjustment problems, including symptoms of depression, anxiety, conduct problems, and peer problems, by elevating in in adolescent’s emotional insecurity about the family system. The clinical implications of these findings are considered. PMID:25131144

Employee Trust in Supervisors and Affective Commitment: The Moderating Role of Authentic Leadership.

PubMed

Xiong, Kehan; Lin, Weipeng; Li, Jenny C; Wang, Lei

2016-06-01

Although previous research has examined the main/direct effects of subordinates' trust in their supervisors on the levels of subordinates' affective commitment towards the organizations, little attention has been paid to explore the boundary conditions of this relationship. Two studies were conducted to examine the moderating effect of authentic leadership on the relationship between subordinates' trust in supervisor and their levels of affective commitment towards the organization. In line with the hypothesized model, both Study 1 (cross-sectional design, n = 138) and Study 2 (lagged design, n = 154) demonstrated that authentic leadership moderated the relationship between employees' trust in supervisor and their levels of affective commitment towards their organizations. Specifically, the positive relationship was stronger for employees under higher levels of authentic leadership. The implications for theory and practice are discussed. © The Author(s) 2016.

Low levels of exposure to libby amphibole asbestos and localized pleural thickening.

PubMed

Christensen, Krista Yorita; Bateson, Thomas F; Kopylev, Leonid

2013-11-01

To explore the relationship between low levels of exposure to Libby amphibole asbestos (LAA) and pleural abnormalities, specifically localized pleural thickening (LPT). Three studies presenting the risks associated with quantitative LAA exposure estimates were reviewed, paying particular attention to lower exposure ranges. Studies reviewed were conducted among workers exposed to LAA at mining and milling operations in Libby, Montana, at a vermiculite processing facility in Marysville, Ohio, and community residents exposed to LAA from a vermiculite processing facility in Minneapolis, Minnesota. Pleural abnormalities were evaluated using radiographs. Despite differences in study populations and design, each study found that cumulative inhalation LAA exposure was associated with increased risk of LPT even at low levels of exposure. Inhalation exposure to LAA is associated with increased risk of LPT even at the lowest levels of exposure in each study.

Dissolved Oxygen Levels in Lake Chabot

NASA Astrophysics Data System (ADS)

Sharma, D.; Pica, R.

2014-12-01

Dissolved oxygen levels are crucial in every aquatic ecosystem; it allows for the fish to breathe and it is the best indicator of water quality. Lake Chabot is the main backup water source for Castro Valley, making it crucial that the lake stays in good health. Last year, research determined that the water in Lake Chabot was of good quality and not eutrophic. This year, an experiment was conducted using Lake Chabot's dissolved oxygen levels to ensure the quality of the water and to support the findings of the previous team. After testing three specifically chosen sites at the lake using a dissolved oxygen meter, results showed that the oxygen levels in the lake were within the healthy range. It was then determined that Lake Chabot is a suitable backup water source and it continues to remain a healthy habitat.

Associations between physical activity and motivation, competence, functioning, and apathy in inhabitants with mental illness from a rural municipality: a cross-sectional study.

PubMed

Farholm, Anders; Sørensen, Marit; Halvari, Hallgeir; Hynnekleiv, Torfinn

2017-11-06

There is increasing evidence for physical activity (PA) having a positive impact on physical and mental health as well as illness symptoms in individuals with severe mental illness (SMI). However, individuals with SMI experience several barriers that makes it difficult to take advantage of the benefits associated with PA. One barrier consistently reported to impede PA is motivational issues. Thus, the main aim of the present study was to examine associations between PA and motivation for PA, perceived competence for PA, functioning, apathy, and demographic variables among individuals with SMI. This was conducted within a larger study aiming at including all inhabitants with SMI in one particular small, rural municipality. A total of 106 participants were recruited to the study. Questionnaire-based interviews conducted by two mental health nurses assessed self-reported PA, motivation and competence for PA, functioning, and apathy. Additionally, 71 participants accepted to wear an accelerometer-equipped wristwatch yielding an objective assessment of PA. The participants engaged in little PA. However, they did not lack motivation, as over 90% stated that they would like to be more active, and participants across PA level displayed high scores of a motivation reflecting that they valued the benefits of PA. Results showed that higher self-reported PA level was associated with higher levels of integrated regulated motivation and perceived competence for PA while it was unrelated to functioning and apathy. In the subpopulation with objectively measured PA, integrated regulated motivation for PA remained significantly associated with PA level, whereas poor scores on functioning lowered the odds ratio for higher PA level. The results show that PA specific motivation is associated with PA even when controlling for functioning and apathy. This highlight the importance of facilitating context specific motivation (i.e., motivation for PA) and that health care practitioners should emphasise helping people with SMI develop more intrinsic forms of motivation.

Assimilable organic carbon (AOC) variation in reclaimed water: Insight on biological stability evaluation and control for sustainable water reuse.

PubMed

Chen, Zhuo; Yu, Tong; Ngo, Huu Hao; Lu, Yun; Li, Guoqiang; Wu, Qianyuan; Li, Kuixiao; Bai, Yu; Liu, Shuming; Hu, Hong-Ying

2018-04-01

This review highlights the importance of conducting biological stability evaluation due to water reuse progression. Specifically, assimilable organic carbon (AOC) has been identified as a practical indicator for microbial occurrence and regrowth which ultimately influence biological stability. Newly modified AOC bioassays aimed for reclaimed water are introduced. Since elevated AOC levels are often detected after tertiary treatment, the review emphasizes that actions can be taken to either limit AOC levels prior to disinfection or conduct post-treatment (e.g. biological filtration) as a supplement to chemical oxidation based approaches (e.g. ozonation and chlorine disinfection). During subsequent distribution and storage, microbial community and possible microbial regrowth caused by complex interactions are discussed. It is suggested that microbial surveillance, AOC threshold values, real-time field applications and surrogate parameters could provide additional information. This review can be used to formulate regulatory plans and strategies, and to aid in deriving relevant control, management and operational guidance. Copyright © 2018 Elsevier Ltd. All rights reserved.

The potential of turmeric (Curcuma xanthorrhiza) in agroforestry system based on silk tree (Albizia chinensis)

NASA Astrophysics Data System (ADS)

Purnomo, D.; Budiastuti, M. S.; Sakya, A. T.; Cholid, M. I.

2018-03-01

Turmeric (Curcuma xanthorrhiza Roxb.) is a traditional medicinal plant. In Indonesia, it is generally cultivated in village home gardens. Famers conducted very simpple cultivation method of turmeric, without specific maintenance and below varies tree. The experiment was conducted by cultivating turmeric below silk trees as in agroforetry system. The experiment was arranged split plot design, the first factor was three level of irradiation (turmeric monoculture/full irradiation, turmeric below silktree with pruning canopy, and turmeric below silk tree no pruning). The second factor was fertilizer NPK 15-15-15 with three levels of doses (100, 150, and 200 kg ha-1). Cultivating turmeric in agroforestry system based on silk tree which were one year old and not yet needed pruning, application of NPK 15-15-15 fertilizer 100 kg ha-1 was enough. The rhizome yield of turmeric 3 months age reaches 139 g per plant (fresh weight). Litter fall from a silk tree one year old in one year is 30 kg per tree per year.

Phase II. Environmental baseline survey of McCormick Ranch, Kirtland Air Force Base, New Mexico. Part 4. Final report, October 1993-January 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hagaraty, G.; Johnson, J.; Middlebrooks, P.

The Phase II EBS results document the extent of environmental contamination believed to be present on McCormick Ranch. Explosive test areas having the greatest potential for containing soil contaminants were identified using several geophysical survey methods: EM 31 terrain conductivity meter, magnetometer/gradiometer, and ground penetrating radar. From the geophysical surveys, five areas selected to conduct further environmental analysis. A total of 310 soil samples were collected from the five areas and 13 specific high explosive test sites. The samples were screened for semi-volatile organic compounds, PETN, TNT, TNT-degradation products, nitrates and radioactivity. Laboratory analyses were performed and no explosives ormore » degradation products were identified. Semi-volatile organic compounds were in 2 samples, manganese was detected in 3 samples, nitrates were discovered below soil action levels, and radiation levels were below background. Consequently, it is unlikely that significant contamination exists.« less

Phase II. Environmental baseline survey of McCormick Ranch, Kirtland Air Force Base, New Mexico. Part 3. Final report, October 1993-January 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hagaraty, G.; Johnson, J.; Middlebrooks, P.

The Phase II EBS results document the extent of environmental contamination believed to be present on McCormick Ranch. Explosive test areas having the greatest potential for containing soil contaminants were identified using several geophysical survey methods: EM 31 terrain conductivity meter, magnetometer/gradiometer, and ground penetrating radar. From the geophysical surveys, five areas were selected to conduct further environmental analysis. A total of 310 soil samples were collected from the five areas and 13 specific high explosive test sites. The samples were screened for semi-volatile organic compounds, PETN, TNT, TNT-degradation products, nitrates and radioactivity. Laboratory analyses were and no explosives ormore » degradation products were identified. Semi-volatile organic compounds were in 2 samples, manganese was detected in 3 samples, nitrates were discovered below soil action levels, and radiation levels were below background. Consequently, it is unlikely that significant contamination exists.« less

Phase II. Environmental baseline survey of McCormick Ranch, Kirtland Air Force Base, New Mexico. Part 1. Final report, October 1993-January 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hagaraty, G.; Johnson, J.; Middlebrooks, P.

The Phase II EBS results document the extent of environmental contamination believed to be present on McCormick Ranch. Explosive test areas having the greatest potential for containing soil contaminants were identified using several geophysical survey methods: EM 31 terrain conductivity meter, magnetometer/gradiometer, and ground penetrating radar. From the geophysical surveys, five areas were selected to conduct further environmental analysis. A total of 310 soil samples were collected from the and 13 specific high explosive test sites. The samples were screened for semi-volatile organic PETN, TNT, TNT-degradation products, nitrates and radioactivity. Laboratory analyses were and no explosives or degradation products weremore » identified. Semi-volatile organic compounds were in 2 samples, manganese was detected in 3 samples, nitrates were discovered below soil action levels, and radiation levels were below background. Consequently, it is unlikely that significant contamination exists.« less

Phase II. Environmental baseline survey of McCormick Ranch, Kirtland Air Force Base, New Mexico. Part 2. Final report, October 1993-January 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hagaraty, G.; Johnson, J.; Middlebrooks, P.

The Phase II EBS results document the extent of environmental contamination believed to be present on McCormick Ranch. Explosive test areas having the greatest potential for containing soil contaminants were identified using several geophysical survey methods: EM 31 terrain conductivity meter, magnetometer/gradiometer, and ground penetrating radar. From the geophysical surveys, five areas were selected to conduct further environmental analysis. A total of 310 soil samples were collected from the five areas and 13 specific high explosive test sites. The samples were screened for semi-volatile organic compounds, PETN, TNT, TNT-degradation products, nitrates and radioactivity. Laboratory analyses were performed and no explosivesmore » or degradation products were identified. Semi-volatile organic compounds were found in 2 samples, manganese was detected in 3 samples, nitrates were discovered below soil action levels, and radiation levels were below background. Consequently, it is unlikely that significant contamination exists.« less

Phase II. Environmental baseline survey of McCormick Ranch, Kirtland Air Force Base, New Mexico. Part 5. Final report, October 1993-January 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hagaraty, G.; Johnson, J.; Middlebrooks, P.

The Phase II EBS results document the extent of environmental contamination believed to be present on McCormick Ranch. Explosive test areas having the greatest potential for containing soil contaminants were identified using several geophysical survey methods: EM 31 terrain conductivity meter, magnetometer/gradiometer, and ground penetrating radar. From the geophysical surveys, five areas were selected to conduct further environmental analysis. A total of 310 soil samples were collected from the areas and 13 specific high explosive test sites. The samples were screened for semi-volatile organic compounds, PETN, TNT, TNT-degradation products, nitrates and radioactivity. Laboratory analyses were performed and no explosives ormore » degradation products were identified. Semi-volatile organic compounds were in 2 samples, manganese was detected in 3 samples, nitrates were discovered below soil action levels and radiation levels were below background. Consequently, it is unlikely that significant contamination exists.« less

Electrolytic decontamination of conductive materials

NASA Astrophysics Data System (ADS)

Campbell, George M.; Nelson, Timothy O.; Parker, John L.; Getty, Richard H.; Hergert, Tom R.; Lindahl, Kirk A.; Peppers, Larry G.

1994-10-01

Using the electrolytic method, we have demonstrated removal of Pu and Am from contaminated conductive material. At EG and G /Rocky Flats, we electrolytically decontaminated stainless steel. Results from this work show removal of fixed contamination, including the following geometries: planar, large radius, bolt holes, glove ports, and protruding studs. More specifically, fixed contamination was reduced from levels ranging from greater than 1 000 000 counts per minute (cpm) down to levels ranging from 1500 to 250 cpm using the electrolytic method. More recently, the electrolytic work has continued at Los Alamos National Laboratory as a joint project with EG and G/Rocky Flats. Impressively, electrolytic decontamination of Pu /Am from U surfaces (10 sq cm per side) shows decreases in swipable contamination from 500 000-1 500 000 disintegrations per minute (dpm) down to 0-2 dpm. Moreover, the solid waste product of the electrolytic method is reduced in volume by more than 50 times compared with the liquid waste produced by the previous U decontamination method -- a hot concentrated acid spray leach process.

CFTR: A new horizon in the pathomechanism and treatment of pancreatitis

PubMed Central

Hegyi, Péter; Wilschanski, Michael; Muallem, Shmuel; Lukacs, Gergely; Sahin-Tóth, Miklós; Uc, Aliye; Gray, Michael A.; Rakonczay, Zoltán; Maléth, József

2017-01-01

Cystic fibrosis transmembrane conductance regulator (CFTR) is an ion channel that conducts chloride and bicarbonate ions across epithelial cell membranes. Mutations in the CFTR gene diminish the ion channel function and lead to impaired epithelial fluid transport in multiple organs such as the lung and the pancreas resulting in cystic fibrosis. Heterozygous carriers of CFTR mutations do not develop cystic fibrosis but exhibit increased risk for pancreatitis and associated pancreatic damage characterized by elevated mucus levels, fibrosis and cyst formation. Importantly, recent studies demonstrated that pancreatitis causing insults, such as alcohol, smoking or bile acids strongly inhibit CFTR function. Furthermore, human studies showed reduced levels of CFTR expression and function in all forms of pancreatitis. These findings indicate that impairment of CFTR is critical in the development of pancreatitis; therefore, correcting CFTR function could be the first specific therapy in pancreatitis. In this review, we summarize recent advances in the field and discuss new possibilities for the treatment of pancreatitis. PMID:26856995

Learning-style bias and the development of psychopathy.

PubMed

Moul, Caroline; Dadds, Mark R

2013-02-01

In accordance with a recently proposed account of amygdala function in psychopathy, it is hypothesized that people with high levels of psychopathic personality traits have a bias in learning style to encode the general valence, and neglect the specific-features, of an outcome. We present a novel learning task designed to operationalize these biases in learning style. The results from pilot samples of healthy adults and children and from a clinical sample of children with conduct problems provide support for the validity of the learning task as a measure of learning style and demonstrate a significant relationship between general-valence style learning and psychopathic personality traits. It is suggested that this relationship may be important for the aetiology of the social-cognitive deficits exhibited by psychopaths. These preliminary results suggest that this measure of learning style has the potential to be utilized as a research tool and may assist with the early identification, and treatment, of children with conduct problems and high levels of callous-unemotional traits.

Validation of a Fecal Glucocorticoid Assay to Assess Adrenocortical Activity in Meerkats Using Physiological and Biological Stimuli

PubMed Central

Heistermann, Michael; Santema, Peter; Dantzer, Ben; Mausbach, Jelena; Ganswindt, Andre; Manser, Marta B.

2016-01-01

In mammals, glucocorticoid (i.e. GC) levels have been associated with specific life-history stages and transitions, reproductive strategies, and a plethora of behaviors. Assessment of adrenocortical activity via measurement of glucocorticoid metabolites in feces (FGCM) has greatly facilitated data collection from wild animals, due to its non-invasive nature, and thus has become an established tool in behavioral ecology and conservation biology. The aim of our study was to validate a fecal glucocorticoid assay for assessing adrenocortical activity in meerkats (Suricata suricatta), by comparing the suitability of three GC enzyme immunoassays (corticosterone, 11β-hydroxyetiocholanolone and 11oxo-etiocholanolone) in detecting FGCM increases in adult males and females following a pharmacological challenge with adrenocorticotropic hormone (ACTH) and biological stimuli. In addition, we investigated the time course characterizing FGCM excretion, the effect of age, sex and time of day on FGCM levels and assessed the potential effects of soil contamination (sand) on FGCM patterns. Our results show that the group specific 11β-hydroxyetiocholanolone assay was most sensitive to FGCM alterations, detecting significant and most distinctive elevations in FGCM levels around 25 h after ACTH administration. We found no age and sex differences in basal FGCM or on peak response levels to ACTH, but a marked diurnal pattern, with FGCM levels being substantially higher in the morning than later during the day. Soil contamination did not significantly affect FGCM patterns. Our results emphasize the importance of conducting assay validations to characterize species-specific endocrine excretion patterns, a crucial step to all animal endocrinology studies using a non-invasive approach. PMID:27077741

Scaling of Ion Thrusters to Low Power

NASA Technical Reports Server (NTRS)

Patterson, Michael J.; Grisnik, Stanley P.; Soulas, George C.

1998-01-01

Analyses were conducted to examine ion thruster scaling relationships in detail to determine performance limits, and lifetime expectations for thruster input power levels below 0.5 kW. This was motivated by mission analyses indicating the potential advantages of high performance, high specific impulse systems for small spacecraft. The design and development status of a 0.1-0.3 kW prototype small thruster and its components are discussed. Performance goals include thruster efficiencies on the order of 40% to 54% over a specific impulse range of 2000 to 3000 seconds, with a lifetime in excess of 8000 hours at full power. Thruster technologies required to achieve the performance and lifetime targets are identified.

Ultrafast Extreme Ultraviolet Spectroscopy of Methylammonium Lead Iodide Perovskite for Carrier Specific Photophysics

NASA Astrophysics Data System (ADS)

Verkamp, Max A.; Lin, Ming-Fu; Ryland, Elizabeth S.; Benke, Kristin; Vura-Weis, Josh

2017-06-01

Methyl ammonium lead iodide (perovskite) is a leading candidate for next-generation solar cell devices. However, the fundamental photophysics responsible for its strong photovoltaic qualities are not fully understood. Ultrafast extreme ultraviolet (XUV) spectroscopy was used to investigate relaxation dynamics in perovskite with carrier specific signals arising from transitions from the common inner-shell level (I 4d) to the valence and conduction bands. Ultrashort (30 fs) pulses of XUV radiation in a broad spectrum (40-70 eV) were obtained using high-harmonic generation in a tabletop instrument. Transient absorption measurements with visible pump and XUV probe directly observed the dynamics of charge carriers after above-band and band-edge excitation.

Plasma carotenoids and tocopherols in relation to prostate-specific antigen (PSA) levels among men with biochemical recurrence of prostate cancer.

PubMed

Antwi, Samuel O; Steck, Susan E; Zhang, Hongmei; Stumm, Lareissa; Zhang, Jiajia; Hurley, Thomas G; Hebert, James R

2015-10-01

Although men presenting with clinically localized prostate cancer (PrCA) often are treated with radical prostatectomy or radiation therapy with curative intent, about 25-40% develop biochemically recurrent PrCA within 5 years of treatment, which has no known cure. Studies suggest that carotenoid and tocopherol intake may be associated with PrCA risk and progression. We examined plasma carotenoid and tocopherol levels in relation to prostate-specific antigen (PSA) levels among men with PSA-defined biochemical recurrence of PrCA. Data analyzed were from a 6-month diet, physical activity and stress-reduction intervention trial conducted in South Carolina among biochemically recurrent PrCA patients (n=39). Plasma carotenoids and tocopherol levels were measured using high-performance liquid chromatography (HPLC). Linear regression was used to estimate least-square means comparing PSA levels of men with high versus low carotenoid/tocopherol levels, adjusting for covariates. After adjusting for baseline PSA level, plasma cis-lutein/zeaxanthin level at 3 months was related inversely to PSA level at 3 months (P=0.0008), while α-tocopherol (P=0.01), β-cryptoxanthin (P=0.01), and all-trans-lycopene (P=0.004) levels at 3 months were related inversely to PSA levels at 6-months. Percent increase in α-tocopherol and trans-β-carotene levels from baseline to month 3 were associated with lower PSA levels at 3 and 6 months. Percent increase in β-cryptoxanthin, cis-lutein/zeaxanthin and all-trans-lycopene were associated with lower PSA levels at 6 months only. Certain plasma carotenoids and tocopherols were related inversely to PSA levels at various timepoints, suggesting that greater intake of foods containing these micronutrients might be beneficial to men with PSA-defined PrCA recurrence. Copyright © 2015. Published by Elsevier Ltd.

Water levels and water quality in the Sparta-Memphis aquifer (middle Claiborne aquifer) in Arkansas, spring-summer 2011

USGS Publications Warehouse

Schrader, T.P.

2014-01-01

The U.S. Geological Survey, in cooperation with the Arkansas Natural Resources Commission and the Arkansas Geological Survey, has monitored water levels in the Sparta Sand of Claiborne Group and Memphis Sand of Claiborne Group (herein referred to as “the Sparta Sand” and “the Memphis Sand,” respectively) since the 1920s. Groundwater withdrawals have increased while water levels have declined since monitoring was initiated. Herein, aquifers in the Sparta Sand and Memphis Sand will be referred to as “the Sparta-Memphis aquifer” throughout Arkansas. During the spring of 2011, 291 water levels were measured in wells completed in the Sparta-Memphis aquifer and used to produce a regional potentiometric-surface map. During the summer of 2011, groundwater-quality samples were collected and measured from 61 wells for specific conductance, pH, and temperature.In the northern half of Arkansas, the regional direction of groundwater flow in the Sparta-Memphis aquifer is generally to the south-southeast and flows east and south in the southern half of Arkansas. The groundwater in the southern half of Arkansas flows away from the outcrop area except where affected by large depressions in the potentiometric surface. The highest and lowest water-level altitudes measured in the Sparta-Memphis aquifer were 326 feet above and 120 feet below National Geodetic Vertical Datum of 1929 (NGVD 29), respectively.Five depressions are located in the following counties: Arkansas, Cleveland, Jefferson, Lincoln, and Prairie; Union; Cross, Poinsett, St. Francis, and Woodruff; Columbia; and Bradley. Two large depressions, centered in Jefferson and Union Counties, are the result of large withdrawals for industrial, irrigation, or public supply. The depression centered in Jefferson County has expanded in recent years into Arkansas and Prairie Counties as a result of large withdrawals for irrigation and public supply. The lowest water-level altitude measured in this depression is approximately 20 feet (ft) higher in 2011 than in 2009. The area enclosed within the 40-ft contour on the 2011 potentiometric-surface map has decreased in area, shifting north in Lincoln County and west in Arkansas County when compared with the 2009 potentiometric-surface map.The depression in Union County is roughly circular within the -60-ft contour. The lowest water-level altitude measurement was 157 ft below NGVD 29 in 2009, with a 37-ft rise to 120 ft below NGVD 29 in 2011. The depression in Union County has diminished and encloses a smaller area than in recent years. In 1993, the -60-ft contour enclosed 632 square miles (mi2). In 2011, the -60-ft contour enclosed 375 mi2, a decrease of 41 percent from 1993. The lowest water-level altitude measurement during 2011 in the center of the depression in Union County represents a rise of 79 ft since 2003. The area enclosed by the lowest altitude contour, 120 ft below NGVD 29, on the 2011 potentiometric-surface map is less than 10 percent of the area enclosed by that same contour on the 2009 potentiometric-surface map.A broad depression in western Poinsett and Cross Counties was first shown in the 1995 potentiometric-surface map. In 2011, the lowest water-level altitude measurement in this depression, 129 ft above NGVD 29, is 2 ft lower than in 2009. The 140-ft contour has extended southwest into northwestern St. Francis and east-central Woodruff Counties in 2011. In Columbia County in 2011, the area of the depression has decreased, with water levels rising about 1 ft since 2005 in the well with the lowest water-level altitude measurement. The depression in Bradley County in 2011 has decreased in area compared to 2007.A water-level difference map was constructed using the difference between water-level measurements made during 2007 and 2011 at 247 wells. The differences in water level between 2007 and 2011 ranged from -17.3 to 45.4 ft, with a mean of 4.1 ft. Water levels generally declined in the northern half of the study area and generally increased in the southern half of the study area. Areas with a general decline in water levels include Lonoke and western Prairie Counties; northern Arkansas County; Miller County; and Craighead, Poinsett, Cross, and Woodruff Counties. Areas with a general rise in water levels include Lafayette, Columbia, Union, Calhoun, and Bradley Counties; Grant, Jefferson, southern Arkansas, Lincoln, Drew, and Desha Counties; and Phillips County.Hydrographs from 183 wells with a minimum of 25 years of water-level measurements were constructed. During the period 1987–2011, county mean annual water levels generally declined. Mean annual declines were between 0.5 foot per year (ft/yr) and 0.0 ft/yr in Ashley, Chicot, Crittenden, Drew, Grant, Jefferson, Lafayette, Mississippi, Monroe, Ouachita, Phillips, Pulaski, St. Francis, and Woodruff Counties. Mean annual declines were between 1.0 ft/yr and 0.5 ft/yr in Bradley, Calhoun, Cleveland, Craighead, Cross, Desha, Lonoke, Miller, Poinsett, and Prairie Counties. Mean annual declines were between 1.5 ft/yr and 1.0 ft/yr in Arkansas, Lee, and Lincoln Counties. The county mean annual water level rose in Columbia, Dallas, and Union Counties about 0.3 ft/yr, 0.1 ft/yr, and 1.2 ft/yr, respectively.Water samples were collected in the summer of 2011 from 61 wells completed in the Sparta-Memphis aquifer and measured onsite for specific conductance, temperature, and pH. Although there is a regional increase in specific conductance to the east and south, anomalous increases occur in some parts of the study area. Specific conductance ranged from 35 microsiemens per centimeter (μS/cm) in Ouachita County to 1,380 μS/cm in Monroe County. Relatively large specific conductance values (greater than 700 mS/cm) occur in samples from wells in Arkansas, Ashley, Clay, Monroe, Phillips, and Union Counties.

Early-starting conduct problems: intersection of conduct problems and poverty.

PubMed

Shaw, Daniel S; Shelleby, Elizabeth C

2014-01-01

The current article reviews extant literature on the intersection between poverty and the development of conduct problems (CP) in early childhood. Associations between exposure to poverty and disruptive behavior are reviewed through the framework of models emphasizing how the stressors associated with poverty indirectly influence child CP by compromising parent psychological resources, investments in children's welfare, and/or caregiving quality. We expand on the best-studied model, the family stress model, by emphasizing the mediating contribution of parent psychological resources on children's risk for early CP, in addition to the mediating effects of parenting. Specifically, we focus on the contribution of maternal depression, in terms of both compromising parenting quality and exposing children to higher levels of stressful events and contexts. Implications of the adapted family stress model are then discussed in terms of its implications for the prevention and treatment of young children's emerging CP.

Eddy current imaging for electrical characterization of silicon solar cells and TCO layers

NASA Astrophysics Data System (ADS)

Hwang, Byungguk; Hillmann, Susanne; Schulze, Martin; Klein, Marcus; Heuer, Henning

2015-03-01

Eddy Current Testing has been mainly used to determine defects of conductive materials and wall thicknesses in heavy industries such as construction or aerospace. Recently, high frequency Eddy Current imaging technology was developed. This enables the acquirement of information of different depth level in conductive thin-film structures by realizing proper standard penetration depth. In this paper, we summarize the state of the art applications focusing on PV industry and extend the analysis implementing achievements by applying spatially resolved Eddy Current Testing. The specific state of frequency and complex phase angle rotation demonstrates diverse defects from front to back side of silicon solar cells and characterizes homogeneity of sheet resistance in Transparent Conductive Oxide (TCO) layers. In order to verify technical feasibility, measurement results from the Multi Parameter Eddy Current Scanner, MPECS are compared to the results from Electroluminescence.

Early-Onset Conduct Problems: Intersection of Conduct Problems and Poverty

PubMed Central

Shaw, Daniel S.; Shelleby, Elizabeth C.

2014-01-01

The current paper reviewed extant literature on the intersection between poverty and the development of conduct problems (CP) in early childhood. Associations between exposure to poverty and disruptive behavior were reviewed through the framework of models emphasizing how the stressors associated with poverty indirectly influence child CP by compromising parent psychological resources, investments in children’s welfare, and/or caregiving quality. We expanded upon the most well studied of these models, the family stress model, by emphasizing the mediating contribution of parent psychological resources on children’s risk for early CP, in addition to the mediating effects of parenting. Specifically, in we focused on the contribution of maternal depression, both in terms of compromising parenting quality and exposing children to even higher levels of stressful events and contexts. Implications of the adapted family stress model were then discussed in terms of its implications for the prevention and treatment of young children’s emerging CP. PMID:24471370

Holistic rubric vs. analytic rubric for measuring clinical performance levels in medical students.

PubMed

Yune, So Jung; Lee, Sang Yeoup; Im, Sun Ju; Kam, Bee Sung; Baek, Sun Yong

2018-06-05

Task-specific checklists, holistic rubrics, and analytic rubrics are often used for performance assessments. We examined what factors evaluators consider important in holistic scoring of clinical performance assessment, and compared the usefulness of applying holistic and analytic rubrics respectively, and analytic rubrics in addition to task-specific checklists based on traditional standards. We compared the usefulness of a holistic rubric versus an analytic rubric in effectively measuring the clinical skill performances of 126 third-year medical students who participated in a clinical performance assessment conducted by Pusan National University School of Medicine. We conducted a questionnaire survey of 37 evaluators who used all three evaluation methods-holistic rubric, analytic rubric, and task-specific checklist-for each student. The relationship between the scores on the three evaluation methods was analyzed using Pearson's correlation. Inter-rater agreement was analyzed by Kappa index. The effect of holistic and analytic rubric scores on the task-specific checklist score was analyzed using multiple regression analysis. Evaluators perceived accuracy and proficiency to be major factors in objective structured clinical examinations evaluation, and history taking and physical examination to be major factors in clinical performance examinations evaluation. Holistic rubric scores were highly related to the scores of the task-specific checklist and analytic rubric. Relatively low agreement was found in clinical performance examinations compared to objective structured clinical examinations. Meanwhile, the holistic and analytic rubric scores explained 59.1% of the task-specific checklist score in objective structured clinical examinations and 51.6% in clinical performance examinations. The results show the usefulness of holistic and analytic rubrics in clinical performance assessment, which can be used in conjunction with task-specific checklists for more efficient evaluation.

Establishment of new complete blood count reference values for healthy Thai adults.

PubMed

Wongkrajang, P; Chinswangwatanakul, W; Mokkhamakkun, C; Chuangsuwanich, N; Wesarachkitti, B; Thaowto, B; Laiwejpithaya, S; Komkhum, O

2018-04-28

Laboratory reference ranges are essential for diagnostic orientation and treatment decision. As complete blood count parameters are influenced by various factors, including gender, geographic origin, and ethnic origin, it is important to establish specific hematologic reference values for specific populations. This study was conducted at the Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Blood samples were taken from healthy adults aged 18-60 years that attended a health check-up program at our hospital during February 2015 to July 2015. Hematologic and routine chemistry analysis were performed. Participants were determined to be healthy based on medical history and routine medical examinations. Serum vitamin B12, folate, ferritin, and hemoglobin typing were also analyzed to exclude the possible presence of anemia. A statistically significant difference was observed between males and females for Hb level, hematocrit level, red blood cell count, mean corpuscular hemoglobin concentration, percentage neutrophils, monocytes and eosinophils, and absolute neutrophil, lymphocyte, basophil, and platelet counts. Accordingly, gender-specific reference intervals were established for all complete blood count parameters in healthy Thai adult population. The reference value ranges established in this study reflect significant differences between genders. It is possible that these reference ranges may be generalizable to adults living in Thailand. The findings of this study emphasize the importance of establishing specific hematologic reference values for specific populations. © 2018 John Wiley & Sons Ltd.

Quantitative microbial faecal source tracking with sampling guided by hydrological catchment dynamics.

PubMed

Reischer, G H; Haider, J M; Sommer, R; Stadler, H; Keiblinger, K M; Hornek, R; Zerobin, W; Mach, R L; Farnleitner, A H

2008-10-01

The impairment of water quality by faecal pollution is a global public health concern. Microbial source tracking methods help to identify faecal sources but the few recent quantitative microbial source tracking applications disregarded catchment hydrology and pollution dynamics. This quantitative microbial source tracking study, conducted in a large karstic spring catchment potentially influenced by humans and ruminant animals, was based on a tiered sampling approach: a 31-month water quality monitoring (Monitoring) covering seasonal hydrological dynamics and an investigation of flood events (Events) as periods of the strongest pollution. The detection of a ruminant-specific and a human-specific faecal Bacteroidetes marker by quantitative real-time PCR was complemented by standard microbiological and on-line hydrological parameters. Both quantitative microbial source tracking markers were detected in spring water during Monitoring and Events, with preponderance of the ruminant-specific marker. Applying multiparametric analysis of all data allowed linking the ruminant-specific marker to general faecal pollution indicators, especially during Events. Up to 80% of the variation of faecal indicator levels during Events could be explained by ruminant-specific marker levels proving the dominance of ruminant faecal sources in the catchment. Furthermore, soil was ruled out as a source of quantitative microbial source tracking markers. This study demonstrates the applicability of quantitative microbial source tracking methods and highlights the prerequisite of considering hydrological catchment dynamics in source tracking study design.

Regional patterns of total nitrogen concentrations in the National Rivers and Streams Assessment

USGS Publications Warehouse

Omernik, James M.; Paulsen, Steven G.; Griffith, Glenn E.; Weber, Marc H.

2016-01-01

Patterns of nitrogen (N) concentrations in streams sampled by the National Rivers and Streams Assessment (NRSA) were examined semiquantitatively to identify regional differences in stream N levels. The data were categorized and analyzed by watershed size classes to reveal patterns of the concentrations that are consistent with the spatial homogeneity in natural and anthropogenic characteristics associated with regional differences in N levels. Ecoregions and mapped information on human activities including agricultural practices were used to determine the resultant regions. Marked differences in N levels were found among the nine aggregations of ecoregions used to report the results of the NRSA. We identified distinct regional patterns of stream N concentrations within the reporting regions that are associated with the characteristics of specific Level III ecoregions, groups of Level III ecoregions, groups of Level IV ecoregions, certain geographic characteristics within ecoregions, and/or particular watershed size classes. We described each of these regions and illustrated their areal extent and median and range in N concentrations. Understanding the spatial variability of nutrient concentrations in flowing waters and the apparent contributions that human and nonhuman factors have on different sizes of streams and rivers is critical to the development of effective water quality assessment and management plans. This semi-quantitative analysis is also intended to identify areas within which more detailed quantitative work can be conducted to determine specific regional factors associated with variations in stream N concentrations.

Age- and Gender-Specific Reference Intervals for Fasting Blood Glucose and Lipid Levels in School Children Measured With Abbott Architect c8000 Chemistry Analyzer.

PubMed

Tamimi, Waleed; Albanyan, Esam; Altwaijri, Yasmin; Tamim, Hani; Alhussein, Fahad

2012-04-01

Reference intervals for pubertal characteristics are influenced by genetic, geographic, dietary and socioeconomic factors. Therefore, the aim of this study was to establish age-specific reference intervals of glucose and lipid levels among local school children. This was cross-sectional study, conducted among Saudi school children. Fasting blood samples were collected from 2149 children, 1138 (53%) boys and 1011 (47%) girls, aged 6 to 18 years old. Samples were analyzed on the Architect c8000 Chemistry System (Abbott Diagnostics, USA) for glucose, cholesterol, triglycerides, HDL and LDL. Reference intervals were established by nonparametric methods between the 2.5th and 97.5th percentiles. Significant differences were observed between boys and girls for cholesterol and triglycerides levels in all age groups (P < 0.02). Only at age 6-7 years and at adolescents, HDL and LDL levels were found to be significant (P < 0.001). No significant differences were seen in glucose levels except at age 12 to 13 years. Saudi children have comparable serum cholesterol levels than their Western counterparts. This may reflect changing dietary habits and increasing affluence in Saudi Arabia. Increased lipid screening is anticipated, and these reference intervals will aid in the early assessment of cardiovascular and diabetes risk in Saudi pediatric populations.

Survey on Metals Contained in Stainless Steel Kitchenware and Tableware.

PubMed

Shiozawa, Yuu; Haneishi, Nahoko; Suzuki, Kumi; Ogimoto, Mami; Takanashi, Mayu; Tomioka, Naoko; Uematsu, Yoko; Monma, Kimio

2017-01-01

Stainless steel kitchenware and tableware on sale in Japan were investigated. Surface elemental composition ratios of 172 samples were analyzed by the fluorescence X-ray method. High levels of manganese (9.59-20.03%)were detected in 17 samples. This finding was confirmed by ICP analysis. Next, we conducted migration tests. Samples conformed to the Italian Specific Migration Limits. Moreover, lead and antimony were not detected in these samples, in accordance with the Japanese Food Sanitation Law.

Reading through ESP in an Undergraduate Law Program (Lectura a través de inglés con propósitos específicos en un programa de derecho de pregrado)

ERIC Educational Resources Information Center

Arias Rodríguez, Gladis Leonor

2014-01-01

This article presents the results of a study conducted among a group of law students in fift h-level English at a Colombian private university, which analyzed the effects of applying reading through English for Specific Purposes under the criteria of the communicative approach. Data were collected through semi-structured interviews, the students'…

Performance Tested Method multiple laboratory validation study of ELISA-based assays for the detection of peanuts in food.

PubMed

Park, Douglas L; Coates, Scott; Brewer, Vickery A; Garber, Eric A E; Abouzied, Mohamed; Johnson, Kurt; Ritter, Bruce; McKenzie, Deborah

2005-01-01

Performance Tested Method multiple laboratory validations for the detection of peanut protein in 4 different food matrixes were conducted under the auspices of the AOAC Research Institute. In this blind study, 3 commercially available ELISA test kits were validated: Neogen Veratox for Peanut, R-Biopharm RIDASCREEN FAST Peanut, and Tepnel BioKits for Peanut Assay. The food matrixes used were breakfast cereal, cookies, ice cream, and milk chocolate spiked at 0 and 5 ppm peanut. Analyses of the samples were conducted by laboratories representing industry and international and U.S governmental agencies. All 3 commercial test kits successfully identified spiked and peanut-free samples. The validation study required 60 analyses on test samples at the target level 5 microg peanut/g food and 60 analyses at a peanut-free level, which was designed to ensure that the lower 95% confidence limit for the sensitivity and specificity would not be <90%. The probability that a test sample contains an allergen given a prevalence rate of 5% and a positive test result using a single test kit analysis with 95% sensitivity and 95% specificity, which was demonstrated for these test kits, would be 50%. When 2 test kits are run simultaneously on all samples, the probability becomes 95%. It is therefore recommended that all field samples be analyzed with at least 2 of the validated kits.

Drought limitations to leaf-level gas exchange: results from a model linking stomatal optimization and cohesion-tension theory.

PubMed

Novick, Kimberly A; Miniat, Chelcy F; Vose, James M

2016-03-01

We merge concepts from stomatal optimization theory and cohesion-tension theory to examine the dynamics of three mechanisms that are potentially limiting to leaf-level gas exchange in trees during drought: (1) a 'demand limitation' driven by an assumption of optimal stomatal functioning; (2) 'hydraulic limitation' of water movement from the roots to the leaves; and (3) 'non-stomatal' limitations imposed by declining leaf water status within the leaf. Model results suggest that species-specific 'economics' of stomatal behaviour may play an important role in differentiating species along the continuum of isohydric to anisohydric behaviour; specifically, we show that non-stomatal and demand limitations may reduce stomatal conductance and increase leaf water potential, promoting wide safety margins characteristic of isohydric species. We used model results to develop a diagnostic framework to identify the most likely limiting mechanism to stomatal functioning during drought and showed that many of those features were commonly observed in field observations of tree water use dynamics. Direct comparisons of modelled and measured stomatal conductance further indicated that non-stomatal and demand limitations reproduced observed patterns of tree water use well for an isohydric species but that a hydraulic limitation likely applies in the case of an anisohydric species. Published 2015. This article is a US Government work and is in the public domain in the USA.

Business Process Modelling is an Essential Part of a Requirements Analysis. Contribution of EFMI Primary Care Working Group.

PubMed

de Lusignan, S; Krause, P; Michalakidis, G; Vicente, M Tristan; Thompson, S; McGilchrist, M; Sullivan, F; van Royen, P; Agreus, L; Desombre, T; Taweel, A; Delaney, B

2012-01-01

To perform a requirements analysis of the barriers to conducting research linking of primary care, genetic and cancer data. We extended our initial data-centric approach to include socio-cultural and business requirements. We created reference models of core data requirements common to most studies using unified modelling language (UML), dataflow diagrams (DFD) and business process modelling notation (BPMN). We conducted a stakeholder analysis and constructed DFD and UML diagrams for use cases based on simulated research studies. We used research output as a sensitivity analysis. Differences between the reference model and use cases identified study specific data requirements. The stakeholder analysis identified: tensions, changes in specification, some indifference from data providers and enthusiastic informaticians urging inclusion of socio-cultural context. We identified requirements to collect information at three levels: micro- data items, which need to be semantically interoperable, meso- the medical record and data extraction, and macro- the health system and socio-cultural issues. BPMN clarified complex business requirements among data providers and vendors; and additional geographical requirements for patients to be represented in both linked datasets. High quality research output was the norm for most repositories. Reference models provide high-level schemata of the core data requirements. However, business requirements' modelling identifies stakeholder issues and identifies what needs to be addressed to enable participation.

Outcome Analysis of Patients With Oral Cavity Cancer and Extracapsular Spread in Neck Lymph Nodes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liao, Chun-Ta, E-mail: liaoct@adm.cgmh.org.tw; Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan; Lee, Li-Yu

Purpose: Extracapsular spread (ECS) in neck lymph nodes is a major adverse prognostic factor in patients with oral cavity squamous cell carcinoma (OSCC). We conducted a retrospective analysis of prognostic factors in this patient group and tried to identify a subset of patients with a worse prognosis suitable for more aggressive therapeutic interventions. Methods and Materials: Enrolled in the study were 255 OSCC patients with ECS in neck nodes and without evidence of distant metastasis. All participants were followed-up for at least 2 years or censored at last follow-up. The 5-year rates of control, distant metastasis, and survival were themore » main outcome measures. Results: Level IV/V lymph node metastases and tumor depth {>=}12 mm were independent predictors of 5-year survival and identified three prognostic groups. In the low-risk group (no level IV/V metastases and tumor depth <12 mm), the 5-year disease-free, disease-specific, and overall survival rates were 60%, 66%, and 50%, respectively. In the intermediate-risk group (no level IV/V metastases and tumor depth {>=}12 mm), the 5-year disease-free, disease-specific, and overall survival rates were 39%, 41%, and 28%, respectively. In the high-risk group (evidence of level IV/V metastases), the 5-year disease-free, disease-specific, and overall survival rates were 14%, 12%, and 10%, respectively. Conclusions: Among OSCC patients with ECS, those with level IV/V metastases appear to have the worst prognosis followed by without level IV/V metastases and tumor depth {>=}12 mm. An aggressive therapeutic approach may be suitable for intermediate- and high-risk patients.« less

The role of context in preschool learning: a multilevel examination of the contribution of context-specific problem behaviors and classroom process quality to low-income children's approaches to learning.

PubMed

Domínguez, Ximena; Vitiello, Virginia E; Fuccillo, Janna M; Greenfield, Daryl B; Bulotsky-Shearer, Rebecca J

2011-04-01

Research suggests that promoting adaptive approaches to learning early in childhood may help close the gap between advantaged and disadvantaged children. Recent research has identified specific child-level and classroom-level variables that are significantly associated with preschoolers' approaches to learning. However, further research is needed to understand the interactive effects of these variables and determine whether classroom-level variables buffer the detrimental effects of child-level risk variables. Using a largely urban and minority sample (N=275) of preschool children, the present study examined the additive and interactive effects of children's context-specific problem behaviors and classroom process quality dimensions on children's approaches to learning. Teachers rated children's problem behavior and approaches to learning and independent assessors conducted classroom observations to assess process quality. Problem behaviors in structured learning situations and in peer and teacher interactions were found to negatively predict variance in approaches to learning. Classroom process quality domains did not independently predict variance in approaches to learning. Nonetheless, classroom process quality played an important role in these associations; high emotional support buffered the detrimental effects of problem behavior, whereas high instructional support exacerbated them. The findings of this study have important implications for classroom practices aimed at helping children who exhibit problem behaviors. Copyright © 2010 Society for the Study of School Psychology. Published by Elsevier Ltd. All rights reserved.

The learning continuum based on student's level of competence and specific pedagogical learning material on physiological aspects from teachers's opinions

NASA Astrophysics Data System (ADS)

Hadi, Ria Fitriyani; Subali, Bambang

2017-08-01

The scope of learning continuum at the conceptual knowledge is formulated based on the student's level of competence and specific pedagogical learning material. The purpose of this study is to develop a learning continuum of specific pedagogical material aspects of physiology targeted for students in primary and secondary education. This research was conducted in Province of Yogyakarta Special Region from October 2016 to January 2017. The method used in this study was survey method. The data were collected using questionnaire that had been validated from the aspects of construct validity and experts judgements. Respondents in this study consist of 281 Science/Biology teachers at Public Junior and Senior High Schools in the Province of Yogyakarta Special Region which spread in Yogyakarta city and 4 regencies namely Sleman, Bantul, Kulonprogo, and Gunungkidul. The data were taken using a census. Data were analyzed using a descriptive analysis technique. The results show the learning continuum of physiology based on teachers's opinion from grade VII, VIII, and IX are taught in grade VII, VIII, IX and X on level of C2 (understanding) and the learning continuum of physiology based on teachers's opinion from grade X, XI and XII are taught in grade X and XI on level of C2 (understanding), C3 (applying), and C4 (analyzing) based on teachers's opinions. The conclusion is that many teachers refer to the existing curriculum rather than their own original idea for developing learning continuum.

A systematic review of validated methods for identifying pulmonary fibrosis and interstitial lung disease using administrative and claims data.

PubMed

Jones, Natalie; Schneider, Gary; Kachroo, Sumesh; Rotella, Philip; Avetisyan, Ruzan; Reynolds, Matthew W

2012-01-01

The Food and Drug Administration's Mini-Sentinel pilot program initially aimed to conduct active surveillance to refine safety signals that emerge for marketed medical products. A key facet of this surveillance is to develop and understand the validity of algorithms for identifying health outcomes of interest (HOIs) from administrative and claims data. This paper summarizes the process and findings of the algorithm review of pulmonary fibrosis and interstitial lung disease. PubMed and Iowa Drug Information Service Web searches were conducted to identify citations applicable to the pulmonary fibrosis/interstitial lung disease HOI. Level 1 abstract reviews and Level 2 full-text reviews were conducted to find articles using administrative and claims data to identify pulmonary fibrosis and interstitial lung disease, including validation estimates of the coding algorithms. Our search revealed a deficiency of literature focusing on pulmonary fibrosis and interstitial lung disease algorithms and validation estimates. Only five studies provided codes; none provided validation estimates. Because interstitial lung disease includes a broad spectrum of diseases, including pulmonary fibrosis, the scope of these studies varied, as did the corresponding diagnostic codes used. Research needs to be conducted on designing validation studies to test pulmonary fibrosis and interstitial lung disease algorithms and estimating their predictive power, sensitivity, and specificity. Copyright © 2012 John Wiley & Sons, Ltd.

The role of muscle mass and body fat on disability among older adults: A cross-national analysis.

PubMed

Tyrovolas, Stefanos; Koyanagi, Ai; Olaya, Beatriz; Ayuso-Mateos, Jose Luis; Miret, Marta; Chatterji, Somnath; Tobiasz-Adamczyk, Beata; Koskinen, Seppo; Leonardi, Matilde; Haro, Josep Maria

2015-09-01

The aim of this study was to evaluate the association of sarcopenia and sarcopenic obesity with disability among older adults (≥65years old) in nine high-, middle- and low-income countries from Asia, Africa, Europe, and Latin America. Data were available for 53,289 people aged ≥18years who participated in the Collaborative Research on Ageing in Europe (COURAGE) survey conducted in Finland, Poland, and Spain, and the WHO Study on global AGEing and adult health (SAGE) survey conducted in China, Ghana, India, Mexico, Russia, and South Africa, between 2007 and 2012. Skeletal muscle mass, skeletal muscle mass index, and percent body fat were calculated with specific population formulas. Sarcopenia and sarcopenic obesity were defined by specific cut-offs used in previous studies. Disability was assessed with the WHODAS 2.0 score (range 0-100) with higher scores corresponding to higher levels of disability. Multivariable linear regression analysis was conducted with disability as the outcome. The analytical sample consisted of 18,363 people (males; n=8116, females; n=10247) aged ≥65years with mean (SD) age 72.9 (11.1) years. In the fully-adjusted overall analysis, sarcopenic obesity was associated with greater levels of disability [b-coefficient 3.01 (95% CI 1.14-4.88)]. In terms of country-wise analyses, sarcopenia was associated with higher WHODAS 2.0 scores in China [b-coefficient 4.56 (95% CI: 3.25-5.87)], Poland [b-coefficient 6.66 (95% CI: 2.17-11.14)], Russia [b-coefficient 5.60 (95% CI: 2.03-9.16)], and South Africa [b-coefficient 7.75 (95% CI: 1.56-13.94)]. Prevention of muscle mass decline may contribute to reducing the global burden of disability. Copyright © 2015 Elsevier Inc. All rights reserved.

Effect of highways and local activities on the quality of underground water in Ogun State, Nigeria: a case study of three districts in Ogun State, Nigeria.

PubMed

Odukoya, Olusegun O; Onianwa, Percy C; Sanusi, Olanrewaju I

2010-09-01

The effect of highways and local activities on the quality of groundwater in Ogun State, Nigeria was investigated. This was done by collecting groundwater samples from three different districts in the state, located in Southwestern Nigeria. The water samples collected at 5 m from the highway and control samples collected at 3 km from the highway were analyzed for the following physicochemical parameters: pH, conductivity, chemical oxygen demand, alkalinity, total hardness, total solid, suspended solid, dissolved solid, chloride, sulfate, phosphate, nitrate, phenol, and the metals-lead, zinc, iron, aluminum, sodium, and potassium. The levels of chromium, copper, and cadmium in the samples were below the detectable limit. The levels of the parameters show that there are significant differences between those in the samples and the controls (F test) except for phosphate and phenol. Also, anthropogenic sources (local activities) elevate the levels of different specific parameters, which are related to these activities. Good correlation was observed between traffic density and lead levels as well as between conductivity and dissolved solids. Comparisons with the World Health Organization guidelines indicate that most of the water samples are not suitable for human consumption.

Knowledge, attitudes, and practices regarding travel health among Muscat International Airport travelers in Oman: Identifying the gaps and addressing the challenges.

PubMed

Al-Abri, Seif S; Abdel-Hady, Doaa M; Al-Abaidani, Idris S

2016-06-01

Although the majority of travel-associated communicable diseases can be prevented, the public health burden of these diseases remains significant. Relatively little is known about how travelers know and perceive the health risks associated with travel and how they utilize preventive measures before and while traveling abroad. This study was conducted to determine the level of the knowledge, attitudes, and practices (KAP) of Muscat International Airport travelers about travel health in order to assess the knowledge gap and the need for travel health services in Oman. A cross-sectional study was conducted over a period of 1week using a self-administered questionnaire. The overall level of knowledge about vaccine-preventable diseases, food safety, and preventive measures against insect bites of the participants was inadequate. The practice concerning preventive travel health measures, such as the use of specific immunizations and antimalarial prophylaxis, was very limited, and influenced by some personal and travel-related factors. The inadequate level of travelers' knowledge and poor utilization of travel medicine services highlights the need for the provisions of specialized travel medicine services at the national level and to develop educational materials promoting the importance of pre-travel health advice. Copyright © 2016 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd. All rights reserved.

Evaluation of a patient specific femoral alignment guide for hip resurfacing.

PubMed

Olsen, Michael; Naudie, Douglas D; Edwards, Max R; Sellan, Michael E; McCalden, Richard W; Schemitsch, Emil H

2014-03-01

A novel alternative to conventional instrumentation for femoral component insertion in hip resurfacing is a patient specific, computed tomography based femoral alignment guide. A benchside study using cadaveric femora was performed comparing a custom alignment guide to conventional instrumentation and computer navigation. A clinical series of twenty-five hip resurfacings utilizing a custom alignment guide was conducted by three surgeons experienced in hip resurfacing. Using cadaveric femora, the custom guide was comparable to conventional instrumentation with computer navigation proving superior to both. Clinical femoral component alignment accuracy was 3.7° and measured within ± 5° of plan in 20 of 24 cases. Patient specific femoral alignment guides provide a satisfactory level of accuracy and may be a better alternative to conventional instrumentation for initial femoral guidewire placement in hip resurfacing. Crown Copyright © 2014. All rights reserved.

Planning and setting objectives in field studies: Chapter 2

USGS Publications Warehouse

Fisher, Robert N.; Dodd, C. Kenneth

2016-01-01

This chapter enumerates the steps required in designing and planning field studies on the ecology and conservation of reptiles, as these involve a high level of uncertainty and risk. To this end, the chapter differentiates between goals (descriptions of what one intends to accomplish) and objectives (the measurable steps required to achieve the established goals). Thus, meeting a specific goal may require many objectives. It may not be possible to define some of them until certain experiments have been conducted; often evaluations of sampling protocols are needed to increase certainty in the biological results. And if sampling locations are fixed and sampling events are repeated over time, then both study-specific covariates and sampling-specific covariates should exist. Additionally, other critical design considerations for field study include obtaining permits, as well as researching ethics and biosecurity issues.

Genetic neuroscience of mammalian learning and memory.

PubMed Central

Tonegawa, Susumu; Nakazawa, Kazu; Wilson, Matthew A

2003-01-01

Our primary research interest is to understand the molecular and cellular mechanisms on neuronal circuitry underlying the acquisition, consolidation and retrieval of hippocampus-dependent memory in rodents. We study these problems by producing genetically engineered (i.e. spatially targeted and/or temporally restricted) mice and analysing these mice by multifaceted methods including molecular and cellular biology, in vitro and in vivo physiology and behavioural studies. We attempt to identify deficits at each of the multiple levels of complexity in specific brain areas or cell types and deduce those deficits that underlie specific learning or memory. We will review our recent studies on the acquisition, consolidation and recall of memories that have been conducted with mouse strains in which genetic manipulations were targeted to specific types of cells in the hippocampus or forebrain of young adult mice. PMID:12740125

Differences in trauma history and psychopathology between PTSD patients with and without co-occurring dissociative disorders

PubMed Central

Wabnitz, Pascal; Gast, Ursula; Catani, Claudia

2013-01-01

Background The interplay between different types of potentially traumatizing events, posttraumatic symptoms, and the pathogenesis of PTSD or major dissociative disorders (DD) has been extensively studied during the last decade. However, the phenomenology and nosological classification of posttraumatic disorders is currently under debate. The current study was conducted to investigate differences between PTSD patients with and without co-occurring major DD with regard to general psychopathology, trauma history, and trauma-specific symptoms. Methods Twenty-four inpatients were administered the Clinician-Administered PTSD Scale for DSM-IV (CAPS) and the Mini-Structured Clinical Interview for DSM-IV Dissociative Disorders (MINI-SKID-D) to assess DD and PTSD. Additionally, participants completed questionnaires to assess general psychopathology and health status. Results Symptom profiles and axis I comorbidity were similar in all patients. Traumatic experiences did not differ between the two groups, with both reporting high levels of childhood trauma. Only trauma-specific avoidance behavior and dissociative symptoms differed between groups. Conclusion Results support the view that PTSD and DD are affiliated disorders that could be classified within the same diagnostic category. Our results accord with a typological model of dissociation in which profound forms of dissociation are specific to DD and are accompanied with higher levels of trauma-specific avoidance in DD patients. PMID:24298325

Differences in trauma history and psychopathology between PTSD patients with and without co-occurring dissociative disorders.

PubMed

Wabnitz, Pascal; Gast, Ursula; Catani, Claudia

2013-01-01

The interplay between different types of potentially traumatizing events, posttraumatic symptoms, and the pathogenesis of PTSD or major dissociative disorders (DD) has been extensively studied during the last decade. However, the phenomenology and nosological classification of posttraumatic disorders is currently under debate. The current study was conducted to investigate differences between PTSD patients with and without co-occurring major DD with regard to general psychopathology, trauma history, and trauma-specific symptoms. Twenty-four inpatients were administered the Clinician-Administered PTSD Scale for DSM-IV (CAPS) and the Mini-Structured Clinical Interview for DSM-IV Dissociative Disorders (MINI-SKID-D) to assess DD and PTSD. Additionally, participants completed questionnaires to assess general psychopathology and health status. Symptom profiles and axis I comorbidity were similar in all patients. Traumatic experiences did not differ between the two groups, with both reporting high levels of childhood trauma. Only trauma-specific avoidance behavior and dissociative symptoms differed between groups. Results support the view that PTSD and DD are affiliated disorders that could be classified within the same diagnostic category. Our results accord with a typological model of dissociation in which profound forms of dissociation are specific to DD and are accompanied with higher levels of trauma-specific avoidance in DD patients.

Correlations Between Allergen-Specific IgE Serum Levels in Patients With Ocular Allergy.

PubMed

Polido, Júlia Gomes Fernandes; Cabral, Thiago; Perini, Paula de Resende Campos; Fernandes, Maria de Fátima Marcelos; de Freitas, Denise; dos Santos Araújo, Maria Emília Xavier; Serracarbassa, Pedro Durães

2015-09-01

To evaluate ocular allergies in patients at the Hospital do Servidor Publico Estadual de Sao Paulo (HSPE) and the correlations with serum allergen-specific immunoglobulin E levels. We performed a longitudinal study of patients with ocular allergies who were treated at the Cornea and Immunology and Allergy Department. Patients underwent an ophthalmologic examination to identify their primary presenting signs and symptoms. The allergy types were divided into 4 groups. We conducted the following laboratory tests and measurements: blood count, eosinophil count, total serum IgE, and specific IgE. Among 61 patients, 16 (26.2%) had a clinical diagnosis of seasonal allergic conjunctivitis, 23 (37.7%) had perennial allergic conjunctivitis, 19 (31.1%) had vernal keratoconjunctivitis, and 3 (4.9%) had atopic keratoconjunctivitis. Mixed dust mites were positive in 94.9% of patients. Dermatophagoides pteronyssinus (dp) and Dermatophagoides farinae (df) antigens were positive in 93.2% of patients followed by Blattella germanica, Blomia tropicalis, and mixed animal epithelia (81%, 75.9%, and 25.8%, respectively). Perennial allergic conjunctivitis was the most prevalent disorder and demonstrated higher positivity in class V/VI for specific antigens (mixed dust mites, dp, and df), indicating high antigenicity. Dust mites, D. pteronyssinus, D. farinae, B. germanica, and B. tropicalis were the primary triggers of the studied ocular allergies.

Medicaid medical directors quality improvement studies: a case study of evolving methods for a research network.

PubMed

Fairbrother, Gerry; Trudnak, Tara; Griffith, Katherine

2014-01-01

To describe the evolution of methods and share lessons learned from conducting multi-state studies with Medicaid Medical Directors (MMD) using state administrative data. There was a great need for these studies, but also much to be learned about conducting network-based research and ensuring comparability of results. This was a network-level case study. The findings were drawn from the experience developing and executing network analyses with the MMDs, as well as from participant feedback on lessons learned. For the latter, nine interviews with MMD project leads, state data analysts, and outside researchers involved with the projects were conducted. Interviews were transcribed, coded and analyzed using NVivo 10.0 analytic software. MMD study methodology involved many steps: developing research questions, defining data specifications, organizing an aggregated data collection spreadsheet form, assuring quality through review, and analyzing and reporting state data at the national level. State analysts extracted the data from their state Medicaid administrative (claims) databases (and sometimes other datasets). Analysis at the national level aggregated state data overall, by demographics and other sub groups, and displayed descriptive statistics and cross-tabs. Projects in the MMD multi-state network address high-priority clinical issues in Medicaid and impact quality of care through sharing of data and policies among states. Further, these studies contribute not only to high-quality, cost-effective health care for Medicaid beneficiaries, but also add to our knowledge of network-based research. Continuation of these studies requires funding for a permanent research infrastructure nationally, as well as at the state-level to strengthen capacity.

Dysfunctional representation of expected value is associated with reinforcement-based decision-making deficits in adolescents with conduct problems.

PubMed

White, Stuart F; Tyler, Patrick M; Erway, Anna K; Botkin, Mary L; Kolli, Venkata; Meffert, Harma; Pope, Kayla; Blair, James R

2016-08-01

Previous work has shown that patients with conduct problems (CP) show impairments in reinforcement-based decision-making. However, studies with patients have not previously demonstrated any relationships between impairment in any of the neurocomputations underpinning reinforcement-based decision-making and specific symptom sets [e.g. level of CP and/or callous-unemotional (CU) traits]. Seventy-two youths [20 female, mean age = 13.81 (SD = 2.14), mean IQ = 102.34 (SD = 10.99)] from a residential treatment program and the community completed a passive avoidance task while undergoing functional MRI. Greater levels of CP were associated with poorer task performance. Reduced representation of expected values (EV) when making avoidance responses within bilateral anterior insula cortex/inferior frontal gyrus (AIC/iFG) and striatum was associated with greater levels of CP but not CU traits. The current data indicate that difficulties in the use of value information to motivate decisions to avoid suboptimal choices are associated with increased levels of CP (though not severity of CU traits). Moreover, they account for the behavioral deficits observed during reinforcement-based decision-making in youth with CP. In short, an individual's relative failure to utilize value information within AIC/iFG to avoid bad choices is associated with elevated levels of CP. © 2016 Association for Child and Adolescent Mental Health.

High Conductivity Carbon-Carbon Heat Pipes for Light Weight Space Power System Radiators

NASA Technical Reports Server (NTRS)

Juhasz, Albert J.

2008-01-01

Based on prior successful fabrication and demonstration testing of a carbon-carbon heat pipe radiator element with integral fins this paper examines the hypothetical extension of the technology via substitution of high thermal conductivity composites which would permit increasing fin length while still maintaining high fin effectiveness. As a result the specific radiator mass could approach an ultimate asymptotic minimum value near 1.0 kg/m2, which is less than one fourth the value of present day satellite radiators. The implied mass savings would be even greater for high capacity space and planetary surface power systems, which may require radiator areas ranging from hundreds to thousands of square meters, depending on system power level.

A reassessment of ground water flow conditions and specific yield at Borden and Cape Cod

USGS Publications Warehouse

Grimestad, Garry

2002-01-01

Recent widely accepted findings respecting the origin and nature of specific yield in unconfined aquifers rely heavily on water level changes observed during two pumping tests, one conducted at Borden, Ontario, Canada, and the other at Cape Cod, Massachusetts. The drawdown patterns observed during those tests have been taken as proof that unconfined specific yield estimates obtained from long-duration pumping tests should approach the laboratory-estimated effective porosity of representative aquifer formation samples. However, both of the original test reports included direct or referential descriptions of potential supplemental sources of pumped water that would have introduced intractable complications and errors into straightforward interpretations of the drawdown observations if actually present. Searches for evidence of previously neglected sources were performed by screening the original drawdown observations from both locations for signs of diagnostic skewing that should be present only if some of the extracted water was derived from sources other than main aquifer storage. The data screening was performed using error-guided computer assisted fitting techniques, capable of accurately sensing and simulating the effects of a wide range of non-traditional and external sources. The drawdown curves from both tests proved to be inconsistent with traditional single-source pumped aquifer models but consistent with site-specific alternatives that included significant contributions of water from external sources. The corrected pumping responses shared several important features. Unsaturated drainage appears to have ceased effectively at both locations within the first day of pumping, and estimates of specific yield stabilized at levels considerably smaller than the corresponding laboratory-measured or probable effective porosity. Separate sequential analyses of progressively later field observations gave stable and nearly constant specific yield estimates for each location, with no evidence from either test that more prolonged pumping would have induced substantially greater levels of unconfined specific yield.

Usability Comparisons of Head-Mounted vs. Stereoscopic Desktop Displays in a Virtual Reality Environment with Pain Patients.

PubMed

Tong, Xin; Gromala, Diane; Gupta, Dimple; Squire, Pam

2016-01-01

Researchers have shown that immersive Virtual Reality (VR) can serve as an unusually powerful pain control technique. However, research assessing the reported symptoms and negative effects of VR systems indicate that it is important to ascertain if these symptoms arise from the use of particular VR display devices, particularly for users who are deemed "at risk," such as chronic pain patients Moreover, these patients have specific and often complex needs and requirements, and because basic issues such as 'comfort' may trigger anxiety or panic attacks, it is important to examine basic questions of the feasibility of using VR displays. Therefore, this repeated-measured experiment was conducted with two VR displays: the Oculus Rift's head-mounted display (HMD) and Firsthand Technologies' immersive desktop display, DeepStream3D. The characteristics of these immersive desktop displays differ: one is worn, enabling patients to move their heads, while the other is peered into, allowing less head movement. To assess the severity of physical discomforts, 20 chronic pain patients tried both displays while watching a VR pain management demo in clinical settings. Results indicated that participants experienced higher levels of Simulator Sickness using the Oculus Rift HMD. However, results also indicated other preferences of the two VR displays among patients, including physical comfort levels and a sense of immersion. Few studies have been conducted that compare usability of specific VR devices specifically with chronic pain patients using a therapeutic virtual environment in pain clinics. Thus, the results may help clinicians and researchers to choose the most appropriate VR displays for chronic pain patients and guide VR designers to enhance the usability of VR displays for long-term pain management interventions.

Estimating hydraulic properties from tidal attenuation in the Northern Guam Lens Aquifer, territory of Guam, USA

USGS Publications Warehouse

Rotzoll, Kolja; Gingerich, Stephen B.; Jenson, John W.; El-Kadi, Aly I.

2013-01-01

Tidal-signal attenuations are analyzed to compute hydraulic diffusivities and estimate regional hydraulic conductivities of the Northern Guam Lens Aquifer, Territory of Guam (Pacific Ocean), USA. The results indicate a significant tidal-damping effect at the coastal boundary. Hydraulic diffusivities computed using a simple analytical solution for well responses to tidal forcings near the periphery of the island are two orders of magnitude lower than for wells in the island’s interior. Based on assigned specific yields of ~0.01–0.4, estimated hydraulic conductivities are ~20–800 m/day for peripheral wells, and ~2,000–90,000 m/day for interior wells. The lower conductivity of the peripheral rocks relative to the interior rocks may best be explained by the effects of karst evolution: (1) dissolutional enhancement of horizontal hydraulic conductivity in the interior; (2) case-hardening and concurrent reduction of local hydraulic conductivity in the cliffs and steeply inclined rocks of the periphery; and (3) the stronger influence of higher-conductivity regional-scale features in the interior relative to the periphery. A simple numerical model calibrated with measured water levels and tidal response estimates values for hydraulic conductivity and storage parameters consistent with the analytical solution. The study demonstrates how simple techniques can be useful for characterizing regional aquifer properties.

Epilithic diatom communities of selected streams from the Lerma-Chapala Basin, Central Mexico, with the description of two new species

PubMed Central

Mora, Demetrio; Carmona, Javier; Jahn, Regine; Zimmermann, Jonas; Abarca, Nélida

2017-01-01

Abstract The Lerma-Chapala Basin, in Central Mexico, is geologically heterogeneous, climatically diverse and boasts high biodiversity, lying within two Biodiversity Hotspots, namely Mesoamerica and the Madrean Pine–Oak Woodlands. Epilithon and water samples were collected in the basin from 14 sampling sites three times each, two sampling campaigns during the rainy season and one in the dry season. A total of 274 infrageneric taxa in 48 genera were recorded. The taxonomic composition observed was dominated by taxa from the genera Nitzschia, Gomphonema, Pinnularia, Navicula, Sellaphora and Eunotia. About a third of the taxa found could not be identified to the species level. From those unidentified morphodemes, two are described as new species, namely Brachysira altepetlensis and Sellaphora queretana. Furthermore, Eolimna rhombica is transferred to Sellaphora. Canonical Correspondence Analysis (CCA) revealed that specific conductivity and pH were the main environmental factors driving the community composition observed. Three groups of samples were identified after the CCA: 1) characterized by acidic waters and low conductivity; 2) with circumneutral waters, low specific conductivity and high temperature and phosphorous concentrations; and 3) characterized by circumneutral waters, high conductivity and low nitrogen concentrations. The indicator value method (IndVal), based on the relative abundance and relative frequency of the most abundant taxa was calculated based on the groups observed in the CCA, identifying the characteristic taxa for each of the three groups. PMID:29118646

A laboratory study of subjective annoyance response to sonic booms and aircraft flyovers

NASA Technical Reports Server (NTRS)

Leatherwood, Jack D.; Sullivan, Brenda M.

1994-01-01

Three experiments were conducted to determine subjective equivalence of aircraft subsonic flyover noise and sonic booms. Two of the experiments were conducted in a loudspeaker-driven sonic boom simulator, and the third in a large room containing conventional loudspeakers. The sound generation system of the boom simulator had a frequency response extending to very low frequencies (about 1 Hz) whereas the large room loudspeakers were limited to about 20 Hz. Subjective equivalence between booms and flyovers was quantified in terms of the difference between the noise level of a boom and that of a flyover when the two were judged equally annoying. Noise levels were quantified in terms of the following noise descriptors: Perceived Level (PL), Perceived Noise Level (PNL), C-weighted sound exposure level (SELC), and A-weighted sound exposure level (SELA). Results from the present study were compared, where possible, to similar results obtained in other studies. Results showed that noise level differences depended upon the descriptor used, specific boom and aircraft noise events being compared and, except for the PNL descriptor, varied between the simulator and large room. Comparison of noise level differences obtained in the present study with those of other studies indicated good agreement across studies only for the PNL and SELA descriptors. Comparison of the present results with assessments of community response to high-energy impulsive sounds made by Working Group 84 of the National Research Council's Committee on Hearing, Bioacoustics, and Biomechanics (CHABA) showed good agreement when boom/flyover noise level differences were based on SELA. However, noise level differences obtained by CHABA using SELA for aircraft flyovers and SELC for booms were not in agreement with results obtained in the present study.

Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy

PubMed Central

Vickery, Brian P.; Scurlock, Amy M.; Kulis, Michael; Steele, Pamela H.; Kamilaris, Janet; Berglund, Jelena P.; Burk, Caitlin; Hiegel, Anne; Carlisle, Suzanna; Christie, Lynn; Perry, Tamara T.; Pesek, Robbie D.; Sheikh, Saira; Virkud, Yamini; Smith, P. Brian; Shamji, Mohamed H.; Durham, Stephen R.; Jones, Stacie M.; Burks, A. Wesley

2013-01-01

Background Although peanut oral immunotherapy (OIT) has been conclusively shown to cause desensitization, it is currently unknown whether clinical protection persists after stopping therapy. Objective Our primary objective was to determine whether peanut OIT can induce sustained unresponsiveness following withdrawal of OIT. Methods We conducted a pilot clinical trial of peanut OIT at two U.S. centers. Subjects aged 1–16 were recruited and treated for up to five years with peanut OIT. The protocol was modified over time to permit dose increases to a maximum of 4000 mg peanut protein/day. Blood was collected at multiple time points. Clinical endpoints were measured with 5000 mg double-blinded, placebo-controlled food challenges once specific criteria were met. Results Of the 39 subjects originally enrolled, 24 completed the protocol and had evaluable outcomes. 12/24 (50%) successfully passed a challenge one month after stopping OIT and achieved sustained unresponsiveness. Peanut was added to the diet. At baseline and the time of challenge, such subjects had smaller skin tests as well as lower IgE levels specific for peanut, Ara h 1, and Ara h 2, and lower ratios of peanut-specific:total IgE, compared to subjects not passing. There were no differences in peanut IgG4 levels or functional activity at end-of-study. Conclusions This is the first demonstration of sustained unresponsiveness after peanut OIT, occurring in half of subjects treated up to five years. OIT favorably modified the peanut-specific immune response in all subjects completing the protocol. Smaller skin tests and lower allergen-specific IgE levels were predictive of successful outcome. PMID:24361082

Virological Outcome after Structured Interruption of Antiretroviral Therapy for Human Immunodeficiency Virus Infection Is Associated with the Functional Profile of Virus-Specific CD8+ T Cells▿

PubMed Central

Daucher, Marybeth; Price, David A.; Brenchley, Jason M.; Lamoreaux, Laurie; Metcalf, Julia A.; Rehm, Catherine; Nies-Kraske, Elizabeth; Urban, Elizabeth; Yoder, Christian; Rock, Diane; Gumkowski, Julie; Betts, Michael R.; Dybul, Mark R.; Douek, Daniel C.

2008-01-01

A clear understanding of the antiviral effects of CD8+ T cells in the context of chronic human immunodeficiency virus (HIV) infection is critical for the development of prophylactic vaccines and therapeutics designed to support T-cell-mediated immunity. However, defining the potential correlates of effective CD8+ T-cell immunity has proven difficult; notably, comprehensive analyses have demonstrated that the size and shape of the CD8+ T-cell response are not necessarily indicative of efficacy determined by measures of plasma viral load. Here, we conducted a detailed quantitative and qualitative analysis of CD8+ T-cell responses to autologous virus in a cohort of six HIV-infected individuals with a history of structured interruption of antiretroviral therapy (ART) (SIT). The magnitude and breadth of the HIV-specific response did not, by themselves, explain the changes observed in plasma virus levels after the cessation of ART. Furthermore, mutational escape from targeted epitopes could not account for the differential virological outcomes in this cohort. However, the functionality of HIV-specific CD8+ T-cell populations upon antigen encounter, determined by the simultaneous and independent measurement of five CD8+ T-cell functions (degranulation and gamma interferon, macrophage inflammatory protein 1β, tumor necrosis factor alpha, and interleukin-2 levels) reflected the emergent level of plasma virus, with multiple functions being elicited in those individuals with lower levels of viremia after SIT. These data show that the quality of the HIV-specific CD8+ T-cell response, rather than the quantity, is associated with the dynamics of viral replication in the absence of ART and suggest that the effects of SIT can be assessed by measuring the functional profile of HIV-specific CD8+ T cells. PMID:18234797

Evaluation of high specific-heat ceramic for regenerator use at temperatures between 2-30 K

NASA Technical Reports Server (NTRS)

Lawless, W. N.

1979-01-01

Specific heat, thermal conductivity (both in the range 2-30 K), and microhardness data were measured on the ceramics labelled LS-8, LS-8A, and LS-8A doped with CsI, SnCl2, and AgCl. A work hardened sample of LS-8A was also studied in an effort to determine the feasibility of using these types of LS-8 materials to replace Pb spheres in the regenerator of the JPL cryocooler. The LS-8A materials are all more than an order of magnitude harder than Pb, and the dopants do not significantly improve the hardness. However, the SnCl2 dopant has a remarkable effect in improving the specific heat and thermal conductivity of LS-8A. The SnCl2 doping level which maximized the regenerator enthalpy change in going from an unloaded to a loaded condition was found to be 0.2 percent SnCl2 in LS-8A. It was also found that the enthalpy change for a regenerator employing the LS-8A material is more than three times larger than for the Pb spheres case. The use of rods, rather than spheres, of optimally doped LS-8A in regenerators is discussed.

Relationship of awards in multiple choice questions and structured answer questions in the undergraduate years and their effectiveness in evaluation.

PubMed

Khan, Junaid Sarfraz; Mukhtar, Osama; Tabasum, Saima; Shaheen, Naveed; Farooq, M; Irfan, M Abdul; Sattar, Ajmal; Nabeel, M; Imran, M; Rafique, Sadia; Iqbal, Maryam; Afzal, M Sheraz; Hameed, M Shahbaz; Habib, Maryam; Jabeen, Uzma; Mubbashar, Malik Hussain

2010-01-01

A number of evaluation tools for assessing the cognitive and affective domains in accordance with Bloom's taxonomy are available for summative assessment. At the University of Health Sciences, Lahore, Multiple Choice Questions (MCQs) and Structured Answer Questions (SAQs) are used for the evaluation of the cognitive domain at all six hierarch levels of taxonomy using the tables of specifications to ensure content validity. The rationale of having two evaluation tools seemingly similar in their evaluative competency yet differing in feasibility of construction, administration and marking is being challenged in this study. The MCQ and SAQ awards of the ten percent sample population amounting to 985 students in fifteen Medical and Dental Colleges across Punjab were entered into SPSS-15 and correlated according to the cognitive and affective level of assessment in relation to the Bloom's taxonomy and their grouping in the Tables of Specifications, using parametric tests. 3494 anonymously administered questionnaires were analyzed using ethnograph. No statistically significant difference was found in the mean marks obtained by the students when MCQs and SAQs were compared according to their groupings in the Tables of Specifications at all levels of cognitive hierarchical testing. End-of-yearcognitive level testing targets set were not met and more questions were set at the lower cognitive testing levels. Expenses incurred in setting MCQs and SAQs were comparable but conduct and assessment costs for MCQs and SAQs were 6% and 94% of the total respectively. In both MCQs and SAQs students performed better at higher cognitive testing levels whereas the SAQs and MCQs were able to marginally test the lower levels of affective domain only. Student's feedback showed that attempting MCQs required critical thinking, experience and practice. MCQs are more cost effective means at levels of cognitive domain assessment.

Serum IGF-1, IGFBP-3 and their ratio: Potential biochemical growth maturity indicators.

PubMed

Jain, Nimisha; Tripathi, Tulika; Gupta, S K; Rai, Priyank; Kanase, Anup; Kalra, Shilpa

2017-12-01

Determination of skeletal maturation and remaining growth potential is an essential part of treatment planning in orthodontics. The aim of our study was to determine the relationship between IGF-1 levels, IGFBP-3 levels with CVM staging to track the pre pubertal and pubertal growth spurts in female patients in North Indian population. This cross-sectional study was conducted on ninety female subjects in the age group of 8-20 years. Blood samples were collected and centrifuged and serum samples were then analysed by Human IGF-1 and IGFBP-3 enzyme-linked immunosorbent assay kits, specific for IGF-1 and IGFBP-3, respectively. CVM staging on lateral cephalometric radiograph was determined for all patients. Analysis of variance test followed by a post hoc test was used to compare mean IGF-1 and IGFBP-3 corresponding to six stages of cervical vertebrae maturation stages. Linear Pearson's correlations were performed to determine the trends of IGF-1, IGFBP-3, and its ratio relating to CVM stage. The kappa statistic was used to measure inter and intra examiner reliability. P value <0.05 was considered as statistically significant. Mean serum IGF-1 levels were found to be highest (403.3 ± 12.3 ng/ml) at CVMI3 stage of CVMI. The post-hoc test revealed a significant difference in IGF-1 levels between all stages of CVMI, thereby indicating a specific range of IGF-1 levels for a specific skeletal stage. Mean serum IGFBP-3 levels were found to be highest (5186.8 ± 1384.2 ng/ml) at CVMI4 stage of CVMI. The mean serum IGFBP-3 levels at CVMI4 were found to be significantly higher than the levels at all other CVMI stages except CVMI3 stage. IGF-1 and IGFBP-3 can serve as a potential biochemical indicator for assessment of skeletal maturity.

The genetic architecture of gene expression levels in wild baboons.

PubMed

Tung, Jenny; Zhou, Xiang; Alberts, Susan C; Stephens, Matthew; Gilad, Yoav

2015-02-25

Primate evolution has been argued to result, in part, from changes in how genes are regulated. However, we still know little about gene regulation in natural primate populations. We conducted an RNA sequencing (RNA-seq)-based study of baboons from an intensively studied wild population. We performed complementary expression quantitative trait locus (eQTL) mapping and allele-specific expression analyses, discovering substantial evidence for, and surprising power to detect, genetic effects on gene expression levels in the baboons. eQTL were most likely to be identified for lineage-specific, rapidly evolving genes; interestingly, genes with eQTL significantly overlapped between baboons and a comparable human eQTL data set. Our results suggest that genes vary in their tolerance of genetic perturbation, and that this property may be conserved across species. Further, they establish the feasibility of eQTL mapping using RNA-seq data alone, and represent an important step towards understanding the genetic architecture of gene expression in primates.

The genetic architecture of gene expression levels in wild baboons

PubMed Central

Tung, Jenny; Zhou, Xiang; Alberts, Susan C; Stephens, Matthew; Gilad, Yoav

2015-01-01

Primate evolution has been argued to result, in part, from changes in how genes are regulated. However, we still know little about gene regulation in natural primate populations. We conducted an RNA sequencing (RNA-seq)-based study of baboons from an intensively studied wild population. We performed complementary expression quantitative trait locus (eQTL) mapping and allele-specific expression analyses, discovering substantial evidence for, and surprising power to detect, genetic effects on gene expression levels in the baboons. eQTL were most likely to be identified for lineage-specific, rapidly evolving genes; interestingly, genes with eQTL significantly overlapped between baboons and a comparable human eQTL data set. Our results suggest that genes vary in their tolerance of genetic perturbation, and that this property may be conserved across species. Further, they establish the feasibility of eQTL mapping using RNA-seq data alone, and represent an important step towards understanding the genetic architecture of gene expression in primates. DOI: http://dx.doi.org/10.7554/eLife.04729.001 PMID:25714927

Forensic facial comparison in South Africa: State of the science.

PubMed

Steyn, M; Pretorius, M; Briers, N; Bacci, N; Johnson, A; Houlton, T M R

2018-06-01

Forensic facial comparison (FFC) is a scientific technique used to link suspects to a crime scene based on the analysis of photos or video recordings from that scene. While basic guidelines on practice and training are provided by the Facial Identification Scientific Working Group, details of how these are applied across the world are scarce. FFC is frequently used in South Africa, with more than 700 comparisons conducted in the last two years alone. In this paper the standards of practice are outlined, with new proposed levels of agreement/conclusions. We outline three levels of training that were established, with training in facial anatomy, terminology, principles of image comparison, image science, facial recognition and computer skills being aimed at developing general competency. Training in generating court charts and understanding court case proceedings are being specifically developed for the South African context. Various shortcomings still exist, specifically with regard to knowledge of the reliability of the technique. These need to be addressed in future research. Copyright © 2018 Elsevier B.V. All rights reserved.

A GIS approach to conducting biogeochemical research in wetlands

NASA Technical Reports Server (NTRS)

Brannon, David P.; Irish, Gary J.

1985-01-01

A project was initiated to develop an environmental data base to address spatial aspects of both biogeochemical cycling and resource management in wetlands. Specific goals are to make regional methane flux estimates and site specific water level predictions based on man controlled water releases within a wetland study area. The project will contribute to the understanding of the Earth's biosphere through its examination of the spatial variability of methane emissions. Although wetlands are thought to be one of the primary sources for release of methane to the atmosphere, little is known about the spatial variability of methane flux. Only through a spatial analysis of methane flux rates and the environmental factors which influence such rates can reliable regional and global methane emissions be calculated. Data will be correlated and studied from Landsat 4 instruments, from a ground survey of water level recorders, precipitation recorders, evaporation pans, and supplemental gauges, and from flood gate water release; and regional methane flux estimates will be made.

Hemoglobin levels and anemia-associated symptoms in pregnant Liberian women.

PubMed

Jackson, R T

1992-01-01

An epidemiological study was conducted of 515 pregnant Liberian women. The purposes of the study were to 1) assess the prevalence of anemia in Liberian women during the last trimester of pregnancy (when latent deficiencies are more apt to become clinically manifest), 2) ascertain which physician-obtained symptoms are related to low hemoglobin (Hb) levels and anemia, and 3) determine the sensitivity and specificity of symptoms commonly associated with anemia. The results indicated that the prevalence of anemia (defined as Hb < 11.0 g/dl) was 79.8%. Women who had headache as a symptom had significantly lower mean Hb values than women who did not have this symptom. The socioeconomic status of women with and without symptoms was not statistically different. The sensitivity of headache as an indicator of anemia and low Hb values was 83%, but the specificity of this symptom was low (27%). The utility of signs and symptoms as indicators is discussed in relation to the economic means of lesser-developed societies and their cultural practices.

Vibration Sensitivity of a Wide-Temperature Electronically Scanned Pressure Measurement (ESP) Module

NASA Technical Reports Server (NTRS)

Zuckerwar, Allan J.; Garza, Frederico R.

2001-01-01

A vibration sensitivity test was conducted on a Wide-Temperature ESP module. The test object was Module "M4," a 16-channel, 4 psi unit scheduled for installation in the Arc Sector of NTF. The module was installed on a vibration exciter and loaded to positive then negative full-scale pressures (+/-2.5 psid). Test variables were the following: Vibration frequencies: 20, 55, 75 Hz. Vibration level: 1 g. Vibration axes: X, Y, Z. The pressure response was measured on each channel, first without and then with the vibration turned on, and the difference analyzed by means of the statistical t-test. The results show that the vibration sensitivity does not exceed 0.01% Full Scale Output per g (with the exception of one channel on one axis) to a 95 percent confidence level. This specification, limited by the resolution of the pressure source, lies well below the total uncertainty specification of 0.1 percent Full Scale Output.

Gender and diversity topics taught in Commission on Accreditation for Marriage and Family Therapy Education programs.

PubMed

Winston, Ebony Joy; Piercy, Fred P

2010-10-01

This article explores how the topics of gender and diversity are being taught and defined in accredited marriage and family therapy programs through syllabi content analysis and interviews with selected faculty. We examined findings by program (master's and doctoral) and type of training (those that taught specific gender and culture courses and those that attempted to infuse gender and culture throughout the curriculum). We examined 39 syllabi from 21 master's and 18 doctoral training programs. In addition, we conducted 20 interviews with faculty members. (Eighteen were White/Caucasian, one was African American and one was Asian Indian.) Some variation in topic areas was found between master's and doctoral programs and between those programs that offered specific course content and those that offered infused course content. However, qualitative interview data reflected many similarities. Particularly apparent was the level of commitment, transparency, and experiential learning methods professors used, regardless of program level or type. © 2010 American Association for Marriage and Family Therapy.

Hydrogeologic data for the northern Rocky Mountains intermontane basins, Montana

USGS Publications Warehouse

Dutton, DeAnn M.; Lawlor, Sean M.; Briar, D.W.; Tresch, R.E.

1995-01-01

The U.S. Geological Survey began a Regional Aquifer- System Analysis of the Northern Rocky Mountains Intermontane Basins of western Montana and central and central and northern Idaho in 1990 to establish a regional framework of information for aquifers in 54 intermontane basins in an area of about 77,500 square miles. Selected hydrogeologic data have been used as part of this analysis to define the hydro- logic systems. Records of 1,376 wells completed in 31 of the 34 intermontane basins in the Montana part of the study area are tabulated in this report. Data consist of location, alttiude of land surface, date well constructed, geologic unit, depth of well, diameter of casing, type of finish, top of open interval, primary use of water, water level, date water level measured, discharge, specific capacity, source of discharge data, type of log available, date water-quality parameters measured, specific conductance, pH, and temperature. Hydrographs for selected wells also are included. Locations of wells and basins are shown on the accompanying plate.

NHS-based Tandem Mass Tagging of Proteins at the Level of Whole Cells: A Critical Evaluation in Comparison to Conventional TMT-Labeling Approaches for Quantitative Proteome Analysis.

PubMed

Megger, Dominik A; Pott, Leona L; Rosowski, Kristin; Zülch, Birgit; Tautges, Stephanie; Bracht, Thilo; Sitek, Barbara

2017-01-01

Tandem mass tags (TMT) are usually introduced at the levels of isolated proteins or peptides. Here, for the first time, we report the labeling of whole cells and a critical evaluation of its performance in comparison to conventional labeling approaches. The obtained results indicated that TMT protein labeling using intact cells is generally possible, if it is coupled to a subsequent enrichment using anti-TMT antibody. The quantitative results were similar to those obtained after labeling of isolated proteins and both were found to be slightly complementary to peptide labeling. Furthermore, when using NHS-based TMT, no specificity towards cell surface proteins was observed in the case of cell labeling. In summary, the conducted study revealed first evidence for the general possibility of TMT cell labeling and highlighted limitations of NHS-based labeling reagents. Future studies should therefore focus on the synthesis and investigation of membrane impermeable TMTs to increase specificity towards cell surface proteins.

Review and analysis of physical exercise at hormonal and brain level, and its influence on appetite.

PubMed

Gómez Escribano, Laura; Gálvez Casas, Arancha; Escribá Fernández-Marcote, Antonio R; Tárraga López, Pedro; Tárraga Marcos, Loreto

Due to the currently growing rate of obesity, it is important to maintain good control of food intake. The main purpose of the present study is to determine the influence of physical exercise on appetite, changes in hormone concentrations, and changes in certain neuronal regions. To achieve this, a literature search was conducted using different data bases. The results show how exercise produces changes in the appetite perception, in the amount of energy intake, and in different weight-control related hormones, as well as in specific neuronal responses. In conclusion, it can be shown that exercise leads to changes in appetite, hunger, and energy intake. In addition, exercise decreases the ghrelin levels and increases concentrations of leptin. Likewise, it is shown how physical exercise alters the responses of certain neuronal regions after visualizing specific food elements decreasing so the appetite or the intake of them. Copyright © 2017 Sociedad Española de Arteriosclerosis. Publicado por Elsevier España, S.L.U. All rights reserved.

The Strength of Family Ties: Perceptions of Network Relationship Quality and Levels of C-Reactive Proteins in the North Texas Heart Study.

PubMed

Uchino, Bert N; Ruiz, John M; Smith, Timothy W; Smyth, Joshua M; Taylor, Daniel J; Allison, Matthew; Ahn, Chul

2015-10-01

Although the quality of one's social relationships has been linked to important physical health outcomes, less work has been conducted examining family and friends that differ in their underlying positivity and negativity. The main aim of this study was to examine the association between supportive, aversive, and ambivalent family/friends with levels of C-reactive proteins. Three hundred participants from the North Texas Heart Study completed the social relationships index and a blood draw to assess high-sensitivity C-reactive proteins (hs-CRPs). After standard controls, the number of supportive family members predicted lower hs-CRP levels, whereas the number of ambivalent family members predicted higher hs-CRP levels. These links were independent of depressive symptoms and perceived stress. These data highlight the importance of considering specific types of relationships and their underlying positive and negative aspects in research on social ties and physical health.

The relations between parents' Big Five personality factors and parenting: a meta-analytic review.

PubMed

Prinzie, Peter; Stams, Geert Jan J M; Deković, Maja; Reijntjes, Albert H A; Belsky, Jay

2009-08-01

To investigate the association between Big Five personality factors and three dimensions of parenting-warmth, behavioral control, and autonomy support-the authors conducted meta-analyses using 5,853 parent-child dyads that were included in 30 studies. Effect sizes were significant and robust across mother and father reports and across assessment methods of parenting (self-report versus observations) but were generally small in magnitude. Higher levels of Extraversion, Agreeableness, Conscientiousness, and Openness and lower levels of Neuroticism were related to more warmth and behavioral control, whereas higher levels of Agreeableness and lower levels of Neuroticism were related to more autonomy support. Several factors moderated the relationship between specific personality dimensions and parenting: child and parental age, reliability of observational assessment of parenting behavior, and study design. Taken together, these results indicate that personality can be seen as an inner resource that affects parenting.

The Role of Audiologic Evaluation in Progressive Audiologic Tinnitus Management

PubMed Central

Henry, James A.; Zaugg, Tara L.; Myers, Paula J.; Schechter, Martin A.

2008-01-01

Progressive Audiologic Tinnitus Management (PATM) is based on the premise that tinnitus is managed most efficiently using a hierarchy of clinical services that address different levels of need. PATM includes five levels of management: (a) triage; (b) audiologic evaluation; (c) group education; (d) tinnitus evaluation; and (e) individualized management. This article provides an overview of PATM and focuses on the procedures that make up the Level 2 Audiologic Evaluation. The evaluation is conducted to assess the potential need for medical, audiologic (hearing loss, tinnitus, hyperacusis), and/or mental health services. The Tinnitus Handicap Inventory, Hearing Handicap Inventory, and Tinnitus and Hearing Survey are used to differentiate effects of tinnitus and hearing loss. If indicated, patients are interviewed with the Tinnitus-Impact Screening Interview. Patients requiring amplification receive hearing aids. Often, management of hearing loss at Level 2 addresses any problems that were attributed to the tinnitus, which obviates further tinnitus-specific intervention. PMID:18628281

Water-quality and ground-water-level data, Bernalillo County, central New Mexico, 1995

USGS Publications Warehouse

Rankin, D.R.

1996-01-01

Water-quality and ground-water-level data were collected in two areas of eastern Bernalillo County in central New Mexico between March and July of 1995. Fifty-one wells, two springs, and the Ojo Grande Acequia in the east mountain area of Bernalillo County and nine wells in the northeast area of the city of Albuquerque were sampled. The water samples were analyzed for selected nutrient species; total organic carbon; major dissolved constituents; dissolved arsenic, boron, iron, and manganese; and methylene blue active substances. Analytical results were used to compute hardness, sodium adsorption ratio, and dissolved solids. Specific conductance, pH, temperature, and alkalinity were measured in the field at the time of sample collection. Ground- water-level and well-depth measurements were made at the time of sample collection when possible. Water-quality data, ground- water-level data, and well-depth data are presented in tabular form.

Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity.

PubMed

Ma, Siming; Upneja, Akhil; Galecki, Andrzej; Tsai, Yi-Miau; Burant, Charles F; Raskind, Sasha; Zhang, Quanwei; Zhang, Zhengdong D; Seluanov, Andrei; Gorbunova, Vera; Clish, Clary B; Miller, Richard A; Gladyshev, Vadim N

2016-11-22

Mammalian lifespan differs by >100 fold, but the mechanisms associated with such longevity differences are not understood. Here, we conducted a study on primary skin fibroblasts isolated from 16 species of mammals and maintained under identical cell culture conditions. We developed a pipeline for obtaining species-specific ortholog sequences, profiled gene expression by RNA-seq and small molecules by metabolite profiling, and identified genes and metabolites correlating with species longevity. Cells from longer lived species up-regulated genes involved in DNA repair and glucose metabolism, down-regulated proteolysis and protein transport, and showed high levels of amino acids but low levels of lysophosphatidylcholine and lysophosphatidylethanolamine. The amino acid patterns were recapitulated by further analyses of primate and bird fibroblasts. The study suggests that fibroblast profiling captures differences in longevity across mammals at the level of global gene expression and metabolite levels and reveals pathways that define these differences.

Monitoring Resistance to Spinosad in the Melon Fly (Bactrocera cucurbitae) in Hawaii and Taiwan

PubMed Central

Hsu, Ju-Chun; Haymer, David S.; Chou, Ming-Yi; Feng, Hai-Tung; Chen, Hsaio-Han; Huang, Yu-Bing; Mau, Ronald F. L.

2012-01-01

Spinosad is a natural insecticide with desirable qualities, and it is widely used as an alternative to organophosphates for control of pests such as the melon fly, Bactrocera cucurbitae (Coquillett). To monitor the potential for development of resistance, information about the current levels of tolerance to spinosad in melon fly populations were established in this study. Spinosad tolerance bioassays were conducted using both topical applications and feeding methods on flies from field populations with extensive exposure to spinosad as well as from collections with little or no prior exposure. Increased levels of resistance were observed in flies from the field populations. Also, higher dosages were generally required to achieve specific levels of mortality using topical applications compared to the feeding method, but these levels were all lower than those used for many organophosphate-based food lures. Our information is important for maintaining effective programs for melon fly management using spinosad. PMID:22629193

A wetland aquifer interaction test

NASA Astrophysics Data System (ADS)

Wise, W. R.; Annable, M. D.; Walser, J. A. E.; Switt, R. S.; Shaw, D. T.

2000-01-01

An understanding of the hydraulic connectivity between an isolated wetland and its underlying groundwater is required to help assess the ecological impact that changes in the groundwater level may induce. Literature values for the hydraulic conductivity of peat vary up to ten orders of magnitude, indicating the absolute necessity of obtaining site-specific information. Horizontal and vertical variability in peat layers makes the process of extrapolating point-based measurements to predict system-level behavior difficult. By inducing or augmenting a flow up from the underlying aquifer into the wetland through a rapid lowering of wetland water level, the system-level hydraulic connectivity of a wetland to the groundwater may be directly measured. At a study site, a small, seasonally flooded depression mash wetland in Florida, the method and subsequent analysis yielded a value for the hydraulic resistance of the organic layer of 6 days, indicating a significant connection between the wetland and the aquifer.

Note on guilt appeals in advertising: covariate effects of self-esteem and locus of control.

PubMed

Pinto, M B; Worobetz, N D

1992-02-01

A 1991 study by Pinto and Priest demonstrated the effectiveness of advertisements employing moderate levels of guilt in inducing guilt responses in subjects. Because individuals' responses to guilt are often influenced by their specific personality characteristics, researchers have pointed to the potential moderating effects of individual difference variables such as level of self-esteem and locus of control on individuals' susceptibility to guilt appeals. A study was conducted to evaluate the possibility that self-esteem and locus of control can act as covariates across three treatment levels of guilt advertising. From a sample of 57 working mothers, advertisements stimulating medium and high levels of guilt elicited significantly greater feelings of guilt in subjects than the control advertisement stimulating low guilt. However, the relationship between susceptibility to guilt appeals and self-esteem and locus of control was not observed to covary.

The influence of spatial organization of the home on inhabitant activity

PubMed Central

Bafna, Sonit; Chambers, Earle

2015-01-01

We describe a study to test whether the arrangement of rooms in an apartment has any systematic association with the levels of activity of its inhabitants. This study was conducted in a sample of Latino adults living in the Bronx, New York. A convenience sample of 19 apartments was selected within the Bronx, NY and one adult volunteer was selected from each household based on who was present at the time of a home visit conducted to collect information on extent of activities. Floor plans for the apartments were obtained from the city authorities. The paper begins by reasoning about the mechanism by which the organization of space can influence levels of activity in the house, and goes on distinguish, first, habitual from deliberate and planned activity, and second, sedentary from more vigorous activity. It is argued that habitual activity would be more susceptible to the influence of spatial organization, and that such habitual activity is likely to be sedentary activity around the house rather than moderate or intense activity. Furthermore, different types of sedentary activity should respond differentially to spatial organization. Specifically, sedentary activities that are susceptible to social life in the house, or require social participation like watching TV or playing cards, should show a positive association with how closely the rooms are knit together, while sedentary activities such as reading, working on computers, and playing video games, that are better conducted in solitary situations, should not. Bivariate analyses showed that interconnectedness (a modified version of integration) was significantly associated with hours spent in socially susceptible sedentary activities but not with hours spent in sedentary activities that occur in solitary conditions, like using the computer or reading. In multivariate analyses, conducted to control for the effects of age and educational level, interconnectedness was still significantly associated with sedentary activity hours. A separate test showed that the positive association with interconnectedness also held for sitting/reclining Hours reported over the day; unlike sedentary activity hours, sitting/reclining hours included activity outside the home as well, so the result raises issues of additional interest. The paper concludes by presenting methodological implications, focusing particularly on how the study could be further developed to model the specific mechanisms by which spatial organization exerts its influence on behavior. PMID:27064359

Conceptual-level workflow modeling of scientific experiments using NMR as a case study

PubMed Central

Verdi, Kacy K; Ellis, Heidi JC; Gryk, Michael R

2007-01-01

Background Scientific workflows improve the process of scientific experiments by making computations explicit, underscoring data flow, and emphasizing the participation of humans in the process when intuition and human reasoning are required. Workflows for experiments also highlight transitions among experimental phases, allowing intermediate results to be verified and supporting the proper handling of semantic mismatches and different file formats among the various tools used in the scientific process. Thus, scientific workflows are important for the modeling and subsequent capture of bioinformatics-related data. While much research has been conducted on the implementation of scientific workflows, the initial process of actually designing and generating the workflow at the conceptual level has received little consideration. Results We propose a structured process to capture scientific workflows at the conceptual level that allows workflows to be documented efficiently, results in concise models of the workflow and more-correct workflow implementations, and provides insight into the scientific process itself. The approach uses three modeling techniques to model the structural, data flow, and control flow aspects of the workflow. The domain of biomolecular structure determination using Nuclear Magnetic Resonance spectroscopy is used to demonstrate the process. Specifically, we show the application of the approach to capture the workflow for the process of conducting biomolecular analysis using Nuclear Magnetic Resonance (NMR) spectroscopy. Conclusion Using the approach, we were able to accurately document, in a short amount of time, numerous steps in the process of conducting an experiment using NMR spectroscopy. The resulting models are correct and precise, as outside validation of the models identified only minor omissions in the models. In addition, the models provide an accurate visual description of the control flow for conducting biomolecular analysis using NMR spectroscopy experiment. PMID:17263870

Conceptual-level workflow modeling of scientific experiments using NMR as a case study.

PubMed

Verdi, Kacy K; Ellis, Heidi Jc; Gryk, Michael R

2007-01-30

Scientific workflows improve the process of scientific experiments by making computations explicit, underscoring data flow, and emphasizing the participation of humans in the process when intuition and human reasoning are required. Workflows for experiments also highlight transitions among experimental phases, allowing intermediate results to be verified and supporting the proper handling of semantic mismatches and different file formats among the various tools used in the scientific process. Thus, scientific workflows are important for the modeling and subsequent capture of bioinformatics-related data. While much research has been conducted on the implementation of scientific workflows, the initial process of actually designing and generating the workflow at the conceptual level has received little consideration. We propose a structured process to capture scientific workflows at the conceptual level that allows workflows to be documented efficiently, results in concise models of the workflow and more-correct workflow implementations, and provides insight into the scientific process itself. The approach uses three modeling techniques to model the structural, data flow, and control flow aspects of the workflow. The domain of biomolecular structure determination using Nuclear Magnetic Resonance spectroscopy is used to demonstrate the process. Specifically, we show the application of the approach to capture the workflow for the process of conducting biomolecular analysis using Nuclear Magnetic Resonance (NMR) spectroscopy. Using the approach, we were able to accurately document, in a short amount of time, numerous steps in the process of conducting an experiment using NMR spectroscopy. The resulting models are correct and precise, as outside validation of the models identified only minor omissions in the models. In addition, the models provide an accurate visual description of the control flow for conducting biomolecular analysis using NMR spectroscopy experiment.

Impact of laws aimed at healthcare-associated infection reduction: a qualitative study.

PubMed

Stone, Patricia W; Pogorzelska-Maziarz, Monika; Reagan, Julie; Merrill, Jacqueline A; Sperber, Brad; Cairns, Catherine; Penn, Matthew; Ramanathan, Tara; Mothershed, Elizabeth; Skillen, Elizabeth

2015-10-01

Healthcare-associated infections (HAIs) are preventable. Globally, laws aimed at reducing HAIs have been implemented. In the USA, these laws are at the federal and state levels. It is not known whether the state interventions are more effective than the federal incentives alone. The aims of this study were to explore the impact federal and state HAI laws have on state departments of health and hospital stakeholders in the USA and to explore similarities and differences in perceptions across states. A qualitative study was conducted. In 2012, we conducted semistructured interviews with key stakeholders from states with and without state-level laws to gain multiple perspectives. Interviews were transcribed and open coding was conducted. Data were analysed using content analysis and collected until theoretical saturation was achieved. Ninety interviews were conducted with stakeholders from 12 states (6 states with laws and 6 states without laws). We found an increase in state-level collaboration. The publicly reported data helped hospitals benchmark and focus leaders on HAI prevention. There were concerns about the publicly reported data (eg, lack of validation and timeliness). Resource needs were also identified. No major differences were expressed by interviewees from states with and without laws. While we could not tease out the impact of specific interventions, increased collaboration between departments of health and their partners is occurring. Harmonisation of HAI definitions and reporting between state and federal laws would minimise reporting burden. Continued monitoring of the progress of HAI prevention is needed. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Workshop I: Systems/Standards/Arrays

NASA Technical Reports Server (NTRS)

Piszczor, Mike; Reed, Brad

2007-01-01

Workshop Format: 1) 1:00 - 3:00 to cover various topics as appropriate; 2) At last SPRAT, conducted Workshop topic on solar cell and array qualification standards. Brad Reed will present update on status of that effort; 3) Second workshop topic: The Future of PV Research within NASA. 4) Any time remaining, specific topics from participants. 5) Reminder for IAPG Members! RECWG today 3:00-5:00 in Federal Room, 2nd Floor OAI. a chart is presented showing: Evaluation of Solar Array Technology Readiness Levels.

Boundary Control Systems, Assessment Remedial Investigation, Version 2. 1. Volume 1

DTIC Science & Technology

1988-12-01

ALLUVIAL WELLS CALCULATED TRANSMISSIVITY VALUES. AND ALLUVIAL WELLS MONITORED. . FOR WATER LEVELS FY87 A.? WELL SITING RATIONALE 10 A-3 WELL COMPLETION...29 Contour Map of Transmissivity of the Alluvial Aquifer 3rd Quarter FY 1987 B-30 Potentiometric Surface, Denver Formation Sand Zone 4 3rd Quarter FY...Monitoring 2-10 2.2-2 Chemical Analysis - Task 25 Anal-tical Program ;-14 4.1-1 Transmissivity (T), Hydraulic Conductivity (K), and 4-12 Apparent Specific

Final Environmental Assessment of Installation Development at Grand Forks Air Force Base, North Dakota

DTIC Science & Technology

2010-07-01

the ground source heat pump system . During installation, construction equipment would remove vegetation from the surface and disturb soil to a depth...levels of 50 to 55 dBA or higher on a daily basis. Studies specifically conducted to determine noise effects on various human activities show that about...needs to be evaluated for its potential effects on a project site and adjacent land uses. The foremost factor affecting a proposed action in terms of

Histone hyperacetylation and exon skipping: a calcium-mediated dynamic regulation in cardiomyocytes

PubMed Central

Sharma, Alok; Nguyen, Hieu; Cai, Lu; Lou, Hua

2015-01-01

In contrast to cell type-specific pre-mRNA alternative splicing, mechanisms controlling activity-dependent alternative splicing is under-studied and not well understood. In a recent study, we conducted a comprehensive analysis of calcium-mediated mechanism that regulates alternative exon skipping in mouse cardiomyocytes. Our results reveal a strong link between histone hyperacetylation and skipping of cassette exons, and provide support to the kinetic coupling model of the epigenetic regulation of alternative splicing at the chromatin level. PMID:26325491

Fuel cell technology program

NASA Technical Reports Server (NTRS)

1972-01-01

A program to advance the technology for a cost-effective hydrogen/oxygen fuel cell system for future manned spacecraft is discussed. The evaluation of base line design concepts and the development of product improvements in the areas of life, power, specific weight and volume, versatility of operation, field maintenance and thermal control were conducted from the material and component level through the fabrication and test of an engineering model of the fuel cell system. The program was to be accomplished in a 13 month period.

Space station contamination control study: Internal combustion, phase 1

NASA Technical Reports Server (NTRS)

Ruggeri, Robert T.

1987-01-01

Contamination inside Space Station modules was studied to determine the best methods of controlling contamination. The work was conducted in five tasks that identified existing contamination control requirements, analyzed contamination levels, developed outgassing specification for materials, wrote a contamination control plan, and evaluated current materials of offgassing tests used by NASA. It is concluded that current contamination control methods can be made to function on the Space Station for up to 1000 days, but that current methods are deficient for periods longer than about 1000 days.

Space shuttle hypergolic bipropellant RCS engine design study, Bell model 8701

NASA Technical Reports Server (NTRS)

1974-01-01

A research program was conducted to define the level of the current technology base for reaction control system rocket engines suitable for space shuttle applications. The project consisted of engine analyses, design, fabrication, and tests. The specific objectives are: (1) extrapolating current engine design experience to design of an RCS engine with required safety, reliability, performance, and operational capability, (2) demonstration of multiple reuse capability, and (3) identification of current design and technology deficiencies and critical areas for future effort.

Guilt in Bereavement: The Role of Self-Blame and Regret in Coping with Loss

PubMed Central

Stroebe, Margaret; Stroebe, Wolfgang; van de Schoot, Rens; Schut, Henk; Abakoumkin, Georgios; Li, Jie

2014-01-01

Despite the apparent centrality of guilt in complicating reactions following bereavement, scientific investigation has been limited. Establishing the impact of specific components associated with guilt could enhance understanding. The aim of this study was to examine the relationships between two guilt-related manifestations, namely self-blame and regret, with grief and depression. A longitudinal investigation was conducted 4–7 months, 14 months and 2 years post-loss. Participants were bereaved spouses (30 widows; 30 widowers); their mean age was 53.05 years. Results showed that self-blame was associated with grief at the initial time-point and with its decline over time. Such associations were not found for depression. Initial levels of regret were neither associated with initial levels of grief and depression, nor were they related to the decline over time in either outcome variable. These results demonstrate the importance of examining guilt-related manifestations independently, over time, and with respect to both generic and grief-specific outcome variables. A main conclusion is that self-blame (but not regret) is a powerful determinant of grief-specific difficulties following the loss of a loved one. Implications for intervention are considered. PMID:24819238

Hydrologic data from selected wells in the Helena Valley, Lewis and Clark County, Montana

USGS Publications Warehouse

Moreland, Joe A.; Leonard, R.B.; Reed, T.E.; Clausen, R.O.; Wood, W.A.

1979-01-01

Hydrologic data were collected during 1978-79 to aid in evaluating the hydrologic conditions in shallow aquifers beneath the Helena Valley, Montana. The locations of 52 shallow test wells augered during the study are shown on a map at a scale of 1:48,000. Periodic water-level measurements and water-quality analyses for the test holes are listed in tables. Water temperature, specific conductance, and nitrate concentration are given for water samples collected from 98 domestic wells, and chemical analyses are included for 11 domestic and irrigation wells. In addition, water-level drawdown and recovery data are plotted on graphs for five pumped wells and three observation wells. (Kosco-USGS)

Addition and subtraction by students with Down syndrome

NASA Astrophysics Data System (ADS)

Noda Herrera, Aurelia; Bruno, Alicia; González, Carina; Moreno, Lorenzo; Sanabria, Hilda

2011-01-01

We present a research report on addition and subtraction conducted with Down syndrome students between the ages of 12 and 31. We interviewed a group of students with Down syndrome who executed algorithms and solved problems using specific materials and paper and pencil. The results show that students with Down syndrome progress through the same procedural levels as those without disabilities though they have difficulties in reaching the most abstract level (numerical facts). The use of fingers or concrete representations (balls) appears as a fundamental process among these students. As for errors, these vary widely depending on the students, and can be attributed mostly to an incomplete knowledge of the decimal number system.

Numerical aerodynamic simulation facility. Preliminary study extension

NASA Technical Reports Server (NTRS)

1978-01-01

The production of an optimized design of key elements of the candidate facility was the primary objective of this report. This was accomplished by effort in the following tasks: (1) to further develop, optimize and describe the function description of the custom hardware; (2) to delineate trade off areas between performance, reliability, availability, serviceability, and programmability; (3) to develop metrics and models for validation of the candidate systems performance; (4) to conduct a functional simulation of the system design; (5) to perform a reliability analysis of the system design; and (6) to develop the software specifications to include a user level high level programming language, a correspondence between the programming language and instruction set and outline the operation system requirements.

Rotavirus specific maternal antibodies and immune response to RV3-BB neonatal rotavirus vaccine in New Zealand.

PubMed

Chen, Mee-Yew; Kirkwood, Carl D; Bines, Julie; Cowley, Daniel; Pavlic, Daniel; Lee, Katherine J; Orsini, Francesca; Watts, Emma; Barnes, Graeme; Danchin, Margaret

2017-05-04

Maternal antibodies, acquired passively via placenta and/or breast milk, may contribute to the reduced efficacy of oral rotavirus vaccines observed in children in developing countries. This study aimed to investigate the effect of rotavirus specific maternal antibodies on the serum IgA response or stool excretion of vaccine virus after any dose of an oral rotavirus vaccine, RV3-BB, in parallel to a Phase IIa clinical trial conducted at Dunedin Hospital, New Zealand. At the time of the study rotavirus vaccines had not been introduced in New Zealand and the burden of rotavirus disease was evident. Rotavirus specific IgG and serum neutralizing antibody (SNA) levels in cord blood and IgA levels in colostrum and breast milk samples collected ∼4 weeks, ∼20 weeks and ∼28 weeks after birth were measured. Infants were randomized to receive the first dose of vaccine at 0-5 d (neonatal schedule) or 8 weeks (infant schedule). Breast feeding was with-held for 30 minutes before and after vaccine administration. The relationship between rotavirus specific IgG and SNA levels in cord blood and IgA in colostrum and breast milk at the time of first active dose of RV3-BB vaccine and level of IgA response and stool excretion after 3 doses of vaccine was assessed using linear and logistic regression. Forty infants received 3 doses of RV3-BB rotavirus vaccine and were included in the analysis of the neonatal and infant groups. Rotavirus specific IgA in colostrum (neonatal schedule group) and breast milk at 4 weeks (infant schedule group) was identified in 14/21 (67%) and 14/17 (82%) of infants respectively. There was little evidence of an association between IgA in colostrum or breast milk IgA at 4 weeks, or between cord IgG or SNA level, and IgA response or stool excretion after 3 doses of RV3-BB, or after one dose (neonatal schedule) (all p>0.05). The level of IgA in colostrum or breast milk and level of placental IgG and SNA did not impact on the serum IgA response or stool excretion following 3 doses of RV3-BB Rotavirus Vaccine administered using either a neonatal or infant schedule in New Zealand infants.

Situational and Generalised Conduct Problems and Later Life Outcomes: Evidence from a New Zealand Birth Cohort

ERIC Educational Resources Information Center

Fergusson, David M.; Boden, Joseph M.; Horwood, L. John

2009-01-01

Background: There is considerable evidence suggesting that many children show conduct problems that are specific to a given context (home; school). What is less well understood is the extent to which children with situation-specific conduct problems show similar outcomes to those with generalised conduct problems. Methods: Data were gathered as…

Water-quality characteristics, including sodium-adsorption ratios, for four sites in the Powder River drainage basin, Wyoming and Montana, water years 2001-2004

USGS Publications Warehouse

Clark, Melanie L.; Mason, Jon P.

2006-01-01

The U.S. Geological Survey, in cooperation with the Wyoming Department of Environmental Quality, monitors streams throughout the Powder River structural basin in Wyoming and parts of Montana for potential effects of coalbed natural gas development. Specific conductance and sodium-adsorption ratios may be larger in coalbed waters than in stream waters that may receive the discharge waters. Therefore, continuous water-quality instruments for specific conductance were installed and discrete water-quality samples were collected to characterize water quality during water years 2001-2004 at four sites in the Powder River drainage basin: Powder River at Sussex, Wyoming; Crazy Woman Creek near Arvada, Wyoming; Clear Creek near Arvada, Wyoming; and Powder River at Moorhead, Montana. During water years 2001-2004, the median specific conductance of 2,270 microsiemens per centimeter at 25 degrees Celsius (?S/cm) in discrete samples from the Powder River at Sussex, Wyoming, was larger than the median specific conductance of 1,930 ?S/cm in discrete samples collected downstream from the Powder River at Moorhead, Montana. The median specific conductance was smallest in discrete samples from Clear Creek (1,180 ?S/cm), which has a dilution effect on the specific conductance for the Powder River at Moorhead, Montana. The daily mean specific conductance from continuous water-quality instruments during the irrigation season showed the same spatial pattern as specific conductance values for the discrete samples. Dissolved sodium, sodium-adsorption ratios, and dissolved solids generally showed the same spatial pattern as specific conductance. The largest median sodium concentration (274 milligrams per liter) and the largest range of sodium-adsorption ratios (3.7 to 21) were measured in discrete samples from the Powder River at Sussex, Wyoming. Median concentrations of sodium and sodium-adsorption ratios were substantially smaller in Crazy Woman Creek and Clear Creek, which tend to decrease sodium concentrations and sodium-adsorption ratios at the Powder River at Moorhead, Montana. Dissolved-solids concentrations in discrete samples were closely correlated with specific conductance values; Pearson's correlation coefficients were 0.98 or greater for all four sites. Regression equations for discrete values of specific conductance and sodium-adsorption ratios were statistically significant (p-values <0.001) at all four sites. The strongest relation (R2=0.92) was at the Powder River at Sussex, Wyoming. Relations on Crazy Woman Creek (R2=0.91) and Clear Creek (R2=0.83) also were strong. The relation between specific conductance and sodium-adsorption ratios was weakest (R2=0.65) at the Powder River at Moorhead, Montana; however, the relation was still significant. These data indicate that values of specific conductance are useful for estimating sodium-adsorption ratios. A regression model called LOADEST was used to estimate dissolved-solids loads for the four sites. The average daily mean dissolved-solids loads varied among the sites during water year 2004. The largest average daily mean dissolved-solids load was calculated for the Powder River at Moorhead, Montana. Although the smallest concentrations of dissolved solids were in samples from Clear Creek, the smallest average daily mean dissolved-solids load was calculated for Crazy Woman Creek. The largest loads occurred during spring runoff, and the smallest loads occurred in late summer, when streamflows typically were smallest. Dissolved-solids loads may be smaller than average during water years 2001-2004 because of smaller than average streamflow as a result of drought conditions.

Sewage plume in a sand and gravel aquifer, Cape Cod, Massachusetts

USGS Publications Warehouse

LeBlanc, D.R.

1982-01-01

Secondarily treated domestic sewage has been disposed of to a sand and gravel aquifer by infiltration through sand beds at Otis Air Force Base, Massachusetts, since 1936. The disposal has formed a plume of contaminated ground water that is more than 11 ,000 feet long, is 2,500 to 3,500 feet wide and 75 feet thick, and is overlain by 20 to 50 feet of uncontaminated ground water derived from precipitation. The distributions of specific conductance, temperature, boron chloride, sodium, phosphorus, nitrogen, ammonia, nitrate, dissolved oxygen, and detergents are used to delineate the plume. The center of the plume contains up to 2.6 milligrams per liter detergents as MBAS (methylene blue active substances), 0.4 milligram per liter boron, 20 milligrams per liter ammonia-nitrogen, and specific conductance as high as 405 micromhos per centimeter. Corresponding levels in uncontaminated ground water are less than 0.1 milligram per liter detergents, less than 0.1 ammonia-nitrogen, less than 0.05 milligram per liter boron, and less than 80 micromhos per centimeter specific conductance. Chloride, sodium, and boron concentrations seem to be affected only by hydrodynamic dispersion. Phosphorus movement is greatly retarded by sorption. Detergent concentrations exceed 0.5 milligram per liter from 3 ,000 to 10,000 feet from the sand beds and reflect the use of nonbiodegradable detergents from 1946 through 1964. The center of the plume as far as 5,000 feet from the sand beds contains nitrogen as ammonia, no nitrate, and no dissolved oxygen. Ammonia is oxidized to nitrate gradually with distance from the center of the plume. (USGS)

Preliminary analysis for trends in selected water-quality characteristics, Powder River, Montana and Wyoming, water years 1952-85

USGS Publications Warehouse

Cary, L.E.

1989-01-01

Selected water-quality data from two streamflow-gaging stations on the Powder River, Montana and Wyoming, were statistically analyzed for trends using the seasonal Kendall test. Data for water years 1952-63 and 1975-85 from the Powder River near Locate, Montana, and water years 1967-68 and 1976-85 from the Powder River at Sussex, Wyoming, were analyzed. Data for the earlier period near Locate were discharge-weighted monthly mean values, whereas data for the late period near Locate and at Sussex were from periodic samples. For data from water years 1952-63 near Locate, increasing trends were detected in sodium and sodium-adsorption ratio; no trends were detected in specific conductance, hardness, non-carbonate hardness, alkalinity, dissolved solids, or sulfate. For data from water years 1975-85 near Locate, increasing trends were detected in specific conductance, sodium, sodium-adsorption ratio, and chloride; no trends were detected in hardness, noncarbonate hardness, alkalinity, dissolved solids, calcium, magnesium, potassium, or sulfate. At Sussex (water years 1967-68 and 1976-85), increasing trends were detected in sodium, sodium-adsorption ratio, and chloride, and a decreasing trend was detected in sulfate. No trends were detected in specific conductance, alkalinity, or dissolved solids. When the 1967-68 data were deleted and the analysis repeated for the 1976-85 data, only sodium-adsorption ratio displayed a significant (increasing) trend. Because the study was exploratory, causes and effects were not considered. The results might have been affected by sample size, number of seasons, heterogeneity, significance level, serial correlation, and data adjustment for changes in discharge. (USGS)

Phenotypically silent Cre recombination within the postnatal ventricular conduction system.

PubMed

Bhattacharyya, Samadrita; Bhakta, Minoti; Munshi, Nikhil Vilas

2017-01-01

The cardiac conduction system (CCS) is composed of specialized cardiomyocytes that initiate and maintain cardiac rhythm. Any perturbation to the normal sequence of electrical events within the heart can result in cardiac arrhythmias. To understand how cardiac rhythm is established at the molecular level, several genetically modified mouse lines expressing Cre recombinase within specific CCS compartments have been created. In general, Cre driver lines have been generated either by homologous recombination of Cre into an endogenous locus or Cre expression driven by a randomly inserted transgene. However, haploinsufficiency of the endogenous gene compromises the former approach, while position effects negatively impact the latter. To address these limitations, we generated a Cre driver line for the ventricular conduction system (VCS) that preserves endogenous gene expression by targeting the Contactin2 (Cntn2) 3' untranslated region (3'UTR). Here we show that Cntn23'UTR-IRES-Cre-EGFP/+ mice recombine floxed alleles within the VCS and that Cre expression faithfully recapitulates the spatial distribution of Cntn2 within the heart. We further demonstrate that Cre expression initiates after birth with preservation of native Cntn2 protein. Finally, we show that Cntn23'UTR-IRES-Cre-EGFP/+ mice maintain normal cardiac mechanical and electrical function. Taken together, our results establish a novel VCS-specific Cre driver line without the adverse consequences of haploinsufficiency or position effects. We expect that our new mouse line will add to the accumulating toolkit of CCS-specific mouse reagents and aid characterization of the cell-autonomous molecular circuitry that drives VCS maintenance and function.

Hydraulics of epiphreatic flow of a karst aquifer

NASA Astrophysics Data System (ADS)

Gabrovšek, Franci; Peric, Borut; Kaufmann, Georg

2018-05-01

The nature of epiphreatic flow remains an important research challenge in karst hydrology. This study focuses on the flood propagation along the epiphreatic system of Reka-Timavo system (Kras/Carso Plateau, Slovenia/Italy). It is based on long-term monitoring of basic physical parameters (pressure/level, temperature, specific electric conductivity) of ground water in six active caves belonging to the flow system. The system vigorously responds to flood events, with stage rising >100 m in some of the caves. Besides presenting the response of the system to flood events of different scales, the work focuses on the interpretation of recorded hydrographs in view of the known distribution and size of conduits and basic hydraulic relations. Furthermore, the hydrographs were used to infer the unknown geometry between the observation points. This way, the main flow restrictors, overflow passages and large epiphreatic storages were identified. The assumptions were tested with a hydraulic model, where the inversion procedure was used for an additional parameter optimisation. Time series of temperature and specific electric conductivity were used to assess the apparent velocities of flow between consecutive points.

Metrology: Measurement Assurance Program Guidelines

NASA Technical Reports Server (NTRS)

Eicke, W. G.; Riley, J. P.; Riley, K. J.

1995-01-01

The 5300.4 series of NASA Handbooks for Reliability and Quality Assurance Programs have provisions for the establishment and utilization of a documented metrology system to control measurement processes and to provide objective evidence of quality conformance. The intent of these provisions is to assure consistency and conformance to specifications and tolerances of equipment, systems, materials, and processes procured and/or used by NASA, its international partners, contractors, subcontractors, and suppliers. This Measurement Assurance Program (MAP) guideline has the specific objectives to: (1) ensure the quality of measurements made within NASA programs; (2) establish realistic measurement process uncertainties; (3) maintain continuous control over the measurement processes; and (4) ensure measurement compatibility among NASA facilities. The publication addresses MAP methods as applied within and among NASA installations and serves as a guide to: control measurement processes at the local level (one facility); conduct measurement assurance programs in which a number of field installations are joint participants; and conduct measurement integrity (round robin) experiments in which a number of field installations participate to assess the overall quality of particular measurement processes at a point in time.

Application of a tree-level hydrodynamic model to simulate plot-level transpiration in the upland oak/pine forest in New Jersey

NASA Astrophysics Data System (ADS)

Mirfenderesgi, G.; Bohrer, G.; Matheny, A. M.; Fatichi, S.; Frasson, R. P. M.; Schafer, K. V.

2015-12-01

The Finite-Elements Tree-Crown Hydrodynamics model version 2 (FETCH2) simulates water flow through the tree using the porous media analogy. Empirical equations relate water potential within the stem to stomatal conductance at the leaf level. Leaves are connected to the stem at each height. While still simplified, this approach brings realism to the simulation of transpiration compared with models where stomatal conductance is directly linked to soil moisture. The FETCH2 model accounts for plant hydraulic traits such as xylem conductivity, area of hydro-active xylem, vertical distribution of leaf area, and maximal and minimal xylem water content, and their effect on the dynamics of water flow in the tree system. Such a modeling tool enhances our understanding of the role of hydraulic limitations and allows us to incorporate the effects of short-term water stresses on transpiration. Here, we use FETCH2 parameterized and evaluated with a large sap-flow observations data set, collected from 21 trees of two genera (oak/pine) at Silas Little Experimental Forest, NJ. The well-drained deep sandy soil leads to water stress during many days throughout the growing season. We conduct a set of tree-level transpiration simulations, and use the results to evaluate the effects of different hydraulic strategies on daily transpiration and water use efficiency. We define these "hydraulic strategies" through combinations of multiple sets of parameters in the model that describe the root, stem and leaf hydraulics. After evaluating the performance of the model, we use the results to shed light on the future trajectory of the forest in terms of species-specific transpiration responses. Application of the model on the two co-occurring oak species (Quercus prinus L. and Quercus velutina Lam) shows that the applied modeling approach was successfully captures the differences in water-use strategy through optimizing multiple physiological and hydraulic parameters.

Time course and predictors of median nerve conduction after carpal tunnel release.

PubMed

Rotman, Mitchell B; Enkvetchakul, Bobby V; Megerian, J Thomas; Gozani, Shai N

2004-05-01

To identify predictors of outcome and of electrophysiologic recovery in patients with carpal tunnel syndrome (CTS) treated by endoscopic carpal tunnel release using a nerve conduction testing system (NC-Stat; NEUROMetrix, Inc, Waltham, MA). Validity of the automated nerve conduction testing system was shown by comparing presurgical distal motor latencies (DMLs) against a reference obtained by referral to an electromyography laboratory. The DML was evaluated in 48 patients with CTS. Measurements were obtained within 1 hour of surgery and at 2 weeks, 6 weeks, 3 months, and 6 months after carpal tunnel release. Presurgical and postsurgical DMLs were then compared and correlated with variables and possible predictors of outcome including age, body mass index, gender, and presurgical DMLs. The automated nerve conduction testing system DMLs matched those of reference electromyography/nerve conduction study values with high correlation. Sensitivity of the automated nerve conduction testing system when compared with a standardized CTS case definition was 89%, with a specificity of 95%. A significant correlation was found between the DML before release and the DML 1 hour after release. Moreover, maximal postsurgical DML improvement was highly dependent on the presurgical DML, with no improvement shown for the <4-ms group, mild improvement for the 4-to-6-ms group, and maximal improvement in the >6-ms group. Among the clinical variables of age, gender, and body mass index only age was mildly predictive of postrelease DML changes at 6 months. No other correlations between clinical variables and postsurgical DMLs were significant. In addition the predictive value of age was lost when combined with the presurgical DML in a multivariate analysis. Postsurgical changes in the median nerve DML were highly dependent on the prerelease latency. The sensitivity and specificity of a nerve conduction monitoring system in detecting and aiding in the diagnosis of CTS is useful in the long-term management of patients with CTS and can aid in determining the level of improvement in median nerve function after endoscopic carpal tunnel release.

Probability analysis of the relation of salinity to freshwater discharge in the St. Sebastian River, Florida

USGS Publications Warehouse

Wicklein, S.M.; Gain, W.S.

1999-01-01

The St. Sebastian River lies in the southern part of the Indian River basin on the east coast of Florida. Increases in freshwater discharge due to urbanization and changes in land use have reduced salinity in the St. Sebastian River and, consequently, salinity in the Indian River, affecting the commercial fishing industry. Wind, water temperature, tidal flux, freshwater discharge, and downstream salinity all affect salinity in the St. Sebastian River estuary, but freshwater discharge is the only one of these hydrologic factors which might be affected by water-management practices. A probability analysis of salinity conditions in the St. Sebastian River estuary, taking into account the effects of freshwater discharge over a period from May 1992 to March 1996, was used to determine the likelihood (probability) that salinities, as represented by daily mean specific- conductance values, will fall below a given threshold. The effects of freshwater discharge on salinities were evaluated with a simple volumetric model fitted to time series of measured specific conductance, by using nonlinear optimization techniques. Specific-conductance values for two depths at monitored sites represent stratified flow which results from differences in salt concentration between freshwater and saltwater. Layering of freshwater and saltwater is assumed, and the model is applied independently to each layer with the assumption that the water within the layer is well mixed. The model of specific conductance as a function of discharge (a salinity response model) was combined with a model of residual variation to produce a total probability model. Flow distributions and model residuals were integrated to produce a salinity distribution and determine differences in salinity probabilities as a result of changes in water-management practices. Two possible management alternatives were analyzed: stormwater detention (reducing the peak rate of discharge but not reducing the overall flow volume) and stormwater retention (reducing peak discharges without later release). Detention of freshwater discharges increased the probability of specific- conductance values falling below a given limit (20,000 microsiemens per centimeter) for all sites but one. The retention of freshwater input to the system decreased the likelihood of falling below a selected limit of specific conductance at all sites. For limits of specific conductance (1,000 microsiemens per centimeter or 20,000 microsiemens per centimeter, depending on the site), the predicted days of occurrence below a limit decreased ranging from 17 to 68 percent of the predicted days of occurrence for unregulated flow. The primary finding to be drawn from the discharge-salinity analysis is that an empirical-response model alone does not provide adequate information to assess the response of the system to changes in flow regime. Whether a given level of discharge can produce a given response on a given day is not as important as the probability of that response on a given day and over a period of many days. A deterministic model of the St. Sebastian River estuary based only on discharge would predict that retention of discharge peaks should increase the average salinity conditions in the St. Sebastian River estuary. The probabilistic model produces a very different response indicating that salinity can decrease by a power of three as discharges increase, and that random factors can predominate and control salinity until discharges increase sufficiently to flush the entire system of saltwater.

One-trial overshadowing: Evidence for fast specific fear learning in humans.

PubMed

Haesen, Kim; Beckers, Tom; Baeyens, Frank; Vervliet, Bram

2017-03-01

Adaptive defensive actions necessitate a fear learning system that is both fast and specific. Fast learning serves to minimize the number of threat confrontations, while specific learning ensures that the acquired fears are tied to threat-relevant cues only. In Pavlovian fear conditioning, fear acquisition is typically studied via repetitive pairings of a single cue with an aversive experience, which is not optimal for the examination of fast specific fear learning. In this study, we adopted the one-trial overshadowing procedure from basic learning research, in which a combination of two visual cues is presented once and paired with an aversive electrical stimulation. Using on-line shock expectancy ratings, skin conductance reactivity and startle reflex modulation as indices of fear learning, we found evidence of strong fear after a single conditioning trial (fast learning) as well as attenuated fear responding when only half of the trained stimulus combination was presented (specific learning). Moreover, specificity of fear responding tended to correlate with levels of state and trait anxiety. These results suggest that one-trial overshadowing can be used as a model to study fast specific fear learning in humans and individual differences therein. Copyright © 2016 Elsevier Ltd. All rights reserved.

TSNA levels in machine-generated mainstream cigarette smoke: 35 years of data.

PubMed

Appleton, Scott; Olegario, Raquel M; Lipowicz, Peter J

2013-07-01

This paper characterizes historical and current tobacco specific nitrosamine (TSNA) levels in mainstream (MS) cigarette smoke of US commercial cigarettes. To conduct this analysis, we gathered 35 years of published data of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N-nitrosonornicotine (NNN) levels in MS cigarette smoke. We also assessed internal data of MS smoke NNK and NNN levels generated from various market monitoring initiatives and from control cigarettes used in a multi-year program for testing cigarette ingredients. In all, we analyzed machine smoking data from 401 cigarette samples representing a wide range of products and design characteristics from multiple manufacturers and market leaders. There was no indication that TSNA levels systematically increased in cigarette MS smoke over the 35-year analysis period. In particular, TSNA levels expressed as either per cigarette or normalized for tar suggest a downward trend in MS smoke over the past 10 years. The apparent downward trend in TSNA levels in MS smoke may reflect industry and agricultural community efforts to reduce levels of TSNAs in tobacco and cigarette smoke. Copyright © 2013 Elsevier Inc. All rights reserved.

Developing a quick and inexpensive in vitro (non-animal) bioassay for mascara irritation.

PubMed

Thomason, H; Montagnes, D J S

2014-04-01

Mascara is a mild irritant that causes a range of medical problems. Animal models to predict ocular irritation have, however, been questioned at a number of levels, and there is a continued need to develop in vitro testing methods. We assess changes in an easily quantifiable attribute, ciliated protozoan growth rate, as a sensitive, sublethal measure. Specifically, we test six, randomly chosen, commercial mascara products against a control (as treatments) and reveal through ANOVA (n = 6, α = 0.05) significant differences in the specific growth rate to treatments (for both protozoa). We provide evidence that two easily cultured protozoa (Paramecium caudatum, Blepharisma japonicum) should be considered as models to assess ocular irritancy (and possibly cosmetics in general) and establish the groundwork for such studies to be applied at a more commercial level. We do this by developing a bioassay for mascara toxicity and indicate the low cost (after equipment is purchased, on the order of $100s) and the ease of performing such tests (able to be conducted by undergraduate students), as a consideration for their future commercial application. We first examined dose dependence of responses, revealing that there was a need to conduct preliminary work to determine appropriate levels for sublethal responses. We then show that some products resulted in mortality at high concentrations, others decreased growth rate by >50% (compared with the control), whereas others had no significant effect, compared with the control. We have provided a novel, quick and inexpensive means to assess mascara; the next step is to validate these ciliate bioassays by comparison with animal testing and epidemiological studies, which is beyond the scope of this fundamental 'proof-of-concept' study. © 2013 Society of Cosmetic Scientists and the Société Française de Cosmétologie.

The Analysis of Fixed Final State Optimal Control in Bilinear System Applied to Bone Marrow by Cell-Cycle Specific (CCS) Chemotherapy

NASA Astrophysics Data System (ADS)

Rainarli, E.; E Dewi, K.

2017-04-01

The research conducted by Fister & Panetta shown an optimal control model of bone marrow cells against Cell Cycle Specific chemotherapy drugs. The model used was a bilinear system model. Fister & Panetta research has proved existence, uniqueness, and characteristics of optimal control (the chemotherapy effect). However, by using this model, the amount of bone marrow at the final time could achieve less than 50 percent from the amount of bone marrow before given treatment. This could harm patients because the lack of bone marrow cells made the number of leukocytes declining and patients will experience leukemia. This research would examine the optimal control of a bilinear system that applied to fixed final state. It will be used to determine the length of optimal time in administering chemotherapy and kept bone marrow cells on the allowed level at the same time. Before simulation conducted, this paper shows that the system could be controlled by using a theory of Lie Algebra. Afterward, it shows the characteristics of optimal control. Based on the simulation, it indicates that strong chemotherapy drug given in a short time frame is the most optimal condition to keep bone marrow cells spine on the allowed level but still could put playing an effective treatment. It gives preference of the weight of treatment for keeping bone marrow cells. The result of chemotherapy’s effect (u) is not able to reach the maximum value. On the other words, it needs to make adjustments of medicine’s dosage to satisfy the final treatment condition e.g. the number of bone marrow cells should be at the allowed level.

Demonstration of frequency-sweep testing technique using a Bell 214-ST helicopter

NASA Technical Reports Server (NTRS)

Tischler, Mark B.; Fletcher, Jay W.; Diekmann, Vernon L.; Williams, Robert A.; Cason, Randall W.

1987-01-01

A demonstration of frequency-sweep testing using a Bell-214ST single-rotor helicopter was completed in support of the Army's development of an updated MIL-H-8501A, and an LHX (ADS-33) handling-qualities specification. Hover and level-flight (V sub a = 0 knots and V sub a = 90 knots) tests were conducted in 3 flight hours by Army test pilots at the Army Aviation Engineering Flight Activity (AEFA) at Edwards AFB, Calif. Bandwidth and phase-delay parameters were determined from the flight-extracted frequency responses as required by the proposed specifications. Transfer function modeling and verification demonstrates the validity of the frequency-response concept for characterizing closed-loop flight dynamics of single-rotor helicopters -- even in hover. This report documents the frequency-sweep flight-testing technique and data-analysis procedures. Special emphasis is given to piloting and analysis considerations which are important for demonstrating frequency-domain specification compliance.

Prostate-specific antigen levels in hypertensive patients suffering from a non-ST elevation myocardial infarction or a new-onset atrial fibrillation.

PubMed

Patanè, Salvatore; Marte, Filippo

2012-07-26

Increasing evidence suggests that prostate-specific antigen kallikrein (PSA) relates to the cardiovascular system. Recently, an association between PSA levels and aortic stiffness has been also reported in untreated essential hypertensive males. Elevated pulse pressure, a surrogate measure for increased proximal aortic stiffness, predisposes to myocardial infarction and atrial fibrillation. No studies, to date, have evaluated the relationship between PSA levels and the occurrence of AMI or new-onset atrial fibrillation in hypertensive male patients. Herein, we conducted a study to investigate this question. This work is a retrospective, observational, study. Consecutive male patients were enrolled and divided in two groups: 58 patients with non-ST elevation myocardial infarction (NSTEMI) and 59 patients with new-onset atrial fibrillation. PSA levels gradually change with age and we prefer to use the percentage of age-specific PSA ranges (a.s. PSA) instead of the simple PSA levels. At multivariate analysis DM [0.263 (0.105-0.662); P=0.005], dyslipidemia [0.301 (0.105-0.863); P=0.025] and a higher percentage of a.s. PSA [0.908 (0.895-0.970); P=0.000] were significantly associated with the occurrence of NSTEMI. The main results of this study showed that a higher percentage of a.s. PSA significantly relates with the occurrence of NSTEMI. In addition, the results of our investigation, also, demonstrate that the significant correlation between higher percentage of a.s. PSA and the occurrence of NSTEMI persisted after adjustment for traditional CAD risk factors (age, DM, dyslipidemia, and smoking). Large studies are needed to further confirm our findings and to elucidate the causes and effects. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Age- and stage-dependent variations of muscle-specific gene expression in brown trout Salmo trutta L.

PubMed

Churova, Maria V; Meshcheryakova, Olga V; Ruchev, Mikhail; Nemova, Nina N

2017-09-01

This study was conducted to characterize the features of muscle-specific genes expression during development of brown trout Salmo trutta inhabiting the river Krivoy ruchey (Kola Peninsula, Russia). Gene expression levels of myogenic regulatory factors (MRFs - MyoD1 paralogs (MyoD1a, MyoD1b, MyoD1c), Myf5, myogenin), myostatin paralogs (MSTN-1a, MSTN-1b, MSTN-2a), fast skeletal myosin heavy chain (MyHC) were measured in the white muscles of brown trout parr of ages 0+ (under-yearling), 1+ (yearling) and 2+ (two year old) and smolts of age 2+. Multidirectional changes in MyoD1 and MSTN paralogs expression along with myogenin, Myf 5 and MyHC expression levels in white muscles in parr of trout with age were revealed. The expression of MyoD1c, myogenin, MSTN-2a was the highest in 0+ parr and then decreased. MyoD1a/b expression levels didn't differ between age groups. The simultaneous elevation of MyHC, Myf5, MSTN-1a, and MSTN-1b was found in trout yearlings. In smolts, expression levels of MSTN paralogs, MyHC, Myf5, MyoD1a was lower than in parr. But in contrast, the MyoD1c and myogenin mRNA levels was higher in smolts. The study revealed that there are definite patterns in simultaneous muscle-specific genes expression in age groups of parr and smolts. As MyoD and MSTN paralogs expression changed differently in dependence on age and stage, it was suggested that paralogs of the same gene complementarily control myogenesis during development. Copyright © 2017 Elsevier Inc. All rights reserved.

Mild neurotrauma indicates a range-specific pressure response to low level shock wave exposure.

PubMed

Vandevord, Pamela J; Bolander, Richard; Sajja, Venkata Siva Sai Sujith; Hay, Kathryn; Bir, Cynthia A

2012-01-01

Identifying the level of overpressure required to create physiological deficits is vital to advance prevention, diagnostic, and treatment strategies for individuals exposed to blasts. In this study, a rodent model of primary blast neurotrauma was employed to determine the pressure at which acute neurological alterations occurred. Rats were exposed to a single low intensity shock wave at a pressure of 0, 97, 117, or 153 kPa. Following exposure, rats were assessed for acute cognitive alterations using the Morris water maze and motor dysfunction using the horizontal ladder test. Subsequently, histological analyses of three brain regions (primary motor cortex, the hippocampal dentate gyrus region, and the posteromedial cortical amygdala) were conducted. Histological parameters included measuring the levels of glial fibrillary acidic protein (GFAP) to identify astrocyte activation, cleaved caspase-3 for early apoptosis identification and Fluoro-Jade B (FJB) which labels degenerating neurons within the brain tissue. The results demonstrated that an exposure to a single 117 kPa shock wave revealed a significant change in overall neurological deficits when compared to controls and the other pressures. The animals showed significant alterations in water maze parameters and a histological increase in the number of GFAP, caspase-3, and FJB-positive cells. It is suggested that when exposed to a low level shock wave, there may be a biomechanical response elicited by a specific pressure range which can cause low level neurological deficits within the rat. These data indicate that neurotrauma induced from a shock wave may lead to cognitive deficits in short-term learning and memory of rats. Additional histological evidence supports significant and diffuse glial activation and cellular damage. Further investigation into the biomechanical aspects of shock wave exposure is required to elucidate this pressure range-specific phenomenon.

Effects of tree height on branch hydraulics, leaf structure and gas exchange in California redwoods.

PubMed

Ambrose, Anthony R; Sillett, Stephen C; Dawson, Todd E

2009-07-01

We examined changes in branch hydraulic, leaf structure and gas exchange properties in coast redwood (Sequoia sempervirens) and giant sequoia (Sequoiadendron giganteum) trees of different sizes. Leaf-specific hydraulic conductivity (k(L)) increased with height in S. sempervirens but not in S. giganteum, while xylem cavitation resistance increased with height in both species. Despite hydraulic adjustments, leaf mass per unit area (LMA) and leaf carbon isotope ratios (delta(13)C) increased, and maximum mass-based stomatal conductance (g(mass)) and photosynthesis (A(mass)) decreased with height in both species. As a result, both A(mass) and g(mass) were negatively correlated with branch hydraulic properties in S. sempervirens and uncorrelated in S. giganteum. In addition, A(mass) and g(mass) were negatively correlated with LMA in both species, which we attributed to the effects of decreasing leaf internal CO(2) conductance (g(i)). Species-level differences in wood density, LMA and area-based gas exchange capacity constrained other structural and physiological properties, with S. sempervirens exhibiting increased branch water transport efficiency and S. giganteum exhibiting increased leaf-level water-use efficiency with increasing height. Our results reveal different adaptive strategies for the two redwoods that help them compensate for constraints associated with growing taller, and reflect contrasting environmental conditions each species faces in its native habitat.

Ethnicity Is an Independent Determinant of Age-Specific PSA Level: Findings from a Multiethnic Asian Setting

PubMed Central

Sothilingam, Selvalingam; Malek, Rohan; Sundram, Murali; Hisham Bahadzor, Badrul; Ong, Teng Aik; Ng, Keng Lim; Sivalingam, Sivaprakasam; Razack, Azad Hassan Abdul

2014-01-01

Objectives To study the baseline PSA profile and determine the factors influencing the PSA levels within a multiethnic Asian setting. Materials and Methods We conducted a cross-sectional study of 1054 men with no clinical evidence of prostate cancer, prostate surgery or 5α-reductase inhibitor treatment of known prostate conditions. The serum PSA concentration of each subject was assayed. Potential factors associated with PSA level including age, ethnicity, height, weight, family history of prostate cancer, lower urinary tract voiding symptoms (LUTS), prostate volume and digital rectal examination (DRE) were evaluated using univariable and multivariable analysis. Results There were 38 men (3.6%) found to have a PSA level above 4 ng/ml and 1016 (96.4%) with a healthy PSA (≤4 ng/ml). The median PSA level of Malay, Chinese and Indian men was 1.00 ng/ml, 1.16 ng/ml and 0.83 ng/ml, respectively. Indians had a relatively lower median PSA level and prostate volume than Malays and Chinese, who shared a comparable median PSA value across all 10-years age groups. The PSA density was fairly similar amongst all ethnicities. Further analysis showed that ethnicity, weight and prostate volume were independent factors associated with age specific PSA level in the multivariable analysis (p<0.05). Conclusion These findings support the concept that the baseline PSA level varies between different ethnicities across all age groups. In addition to age and prostate volume, ethnicity may also need to be taken into account when investigating serum PSA concentrations in the multiethnic Asian population. PMID:25111507

[Intradiverticular bladder tumours: review of the Cancer Committee of the French Association of Urology].

PubMed

Neuzillet, Y; Comperat, E; Rouprêt, M; Larre, S; Roy, C; Quintens, H; Houede, N; Pignot, G; Wallerand, H; Soulie, M; Pfister, C

2012-07-01

Cancer Committee of the French Association of Urology (CCAFU) conducted a review of the epidemiology, diagnosis and treatment of intradiverticular bladder tumours (TVID) and proposed therapeutic management. A bibliographic research in French and English using Medline(®) with the keywords "tumor", "bladder" and "diverticulum" was performed. TVID are more frequently of stage T ≥ 3a and with non urothelial histology than classical bladder tumors. At diagnosis, the risk of underestimation of the extent and multifocality of the tumor was described. Their prognosis, that was more pejorative than conventional tumors, should impelled to limit the indications of conservative treatment. The evidence levels of analyzed publications were low, with C level according to Sackett score. the specificities of the TVID have lead the CCAFU to propose specific therapeutic guidelines, based on poor evidence level. Ta-T1 low grade TVID can be treated by transurethral resection alone or followed by BCG therapy in cases of associated carcinoma in situ. High-grade TVID, unifocal and without associated carcinoma in situ, can be treated by diverticulectomy associated with pelvic lymphadenectomy. High grade TVID, multiple or associated with carcinoma in situ, warranted total cystectomy. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

Consumer health information for pet owners

PubMed Central

Murphy, Sarah Anne

2006-01-01

Objective: The author studied health information available for veterinary consumers both in print and online. Methods: WorldCat was searched using a list of fifty-three Library of Congress subject headings relevant to veterinary consumer health to identify print resources for review. Identified items were then collected and assessed for authority, comprehensiveness of coverage, validity, and other criteria outlined by Rees. An in-depth assessment of the information available for feline lower urinary tract disease (FLUTD) and canine congestive heart failure (CHF) was then conducted to examine the availability and quality of information available for specific diseases and disorders. A reading grade level was assigned for each passage using the Flesch-Kincaid formula in the Readability Statistics feature in Microsoft Word. Results/Discussion: A total of 187 books and 7 Websites were identified and evaluated. More than half of the passages relating to FLUTD and CHF were written above an 11th-grade reading level. A limited quantity of quality, in-depth resources that address specific diseases and disorders and are written at an appropriate reading level for consumers is available. Conclusion: The library's role is to facilitate access to the limited number of quality consumer health resources that are available to veterinary consumers. PMID:16636707

Molecularly resolved protein electromechanical properties.

PubMed

Axford, Daniel; Davis, Jason J; Wang, Nan; Wang, Dongxu; Zhang, Tiantian; Zhao, Jianwei; Peters, Ben

2007-08-02

Previous work has shown that protein molecules can be trapped between the conductive surfaces presented by a metal-coated AFM probe and an underlying planar substrate where their molecule-specific conductance characteristics can be assayed. Herein, we demonstrate that transport across such a derived metal-protein-electrode junction falls within three, pressure-dependent, regimes and, further, that pressure-dependent conductance can be utilized in analyzing temporal variations of protein fold. Specifically, the electronic and mechanical properties of the metalloprotein azurin have been characterized under conditions of anisotropic vertical compression through the use of a conducting atomic force microscope (CP-AFM). By utilizing the ability of azurin to chemically self-assemble on the gold surface presented either by the apex of a suitably coated AFM probe or a planar metallic surface, molecular-level transport characteristics are assayable. Under conditions of low force, typically less than 2 nN, the weak physical and electronic coupling between the protein and the conducting contacts impedes tunneling and leads to charge buildup followed by dielectric breakdown. At slightly increased force, 3-5 nN, the copper protein exhibits temporal electron occupation with observable negative differential resistance, while the redox-inactive zinc mutant does not. At imposed loads greater than 5 nN, appreciable electron tunneling can be detected even at low bias for both the redox-active and -inactive species. Dynamic current-voltage characteristics have been recorded and are well-described by a modified Simmons tunneling model. Subsequent analyses enable the electron tunneling barrier height and barrier length to be determined under conditions of quantified vertical stress. The variance observed describes, in essence, the protein's mechanical properties within the confines of the tunnel junction.

Tunable zero-line modes via magnetic field in bilayer graphene

NASA Astrophysics Data System (ADS)

Wang, Ke; Qiao, Zhenhua

Zero-line modes appear in bilayer graphene at the internal boundary between two opposite vertical electrostatic confinements. These one-dimensional modes are metallic along the boundary and exhibit quantized conductance in the absence of inter-valley scattering. However, experimental results show that the conductance is around 0.5 e2/h rather than quantized. This observation can be explained from our numerical results, which suggest that the scattering between zero-line mode and bound states and the presence of atomic scale disorders that provide inter-valley scattering can effectively reduce the conductance to about 0.5 e2/h. We further find that out-of-plane magnetic field can strongly suppress these scattering mechanisms and gives rise to nearly quantized conductance. On one hand, the presence of magnetic field makes bound states become Landau levels, which reduces the scattering between zero-line mode and bound states. On the other hand, the wave function distributions of oppositely propagating zero-line modes at different valleys are spatially separated, which can strongly suppress the inter-valley scattering. Specifically speaking, the conductance can be increased to 3.2 e2/h at 8 T even when the atomic Anderson type disorders are considered.

Comparing Realistic Subthalamic Nucleus Neuron Models

NASA Astrophysics Data System (ADS)

Njap, Felix; Claussen, Jens C.; Moser, Andreas; Hofmann, Ulrich G.

2011-06-01

The mechanism of action of clinically effective electrical high frequency stimulation is still under debate. However, recent evidence points at the specific activation of GABA-ergic ion channels. Using a computational approach, we analyze temporal properties of the spike trains emitted by biologically realistic neurons of the subthalamic nucleus (STN) as a function of GABA-ergic synaptic input conductances. Our contribution is based on a model proposed by Rubin and Terman and exhibits a wide variety of different firing patterns, silent, low spiking, moderate spiking and intense spiking activity. We observed that most of the cells in our network turn to silent mode when we increase the GABAA input conductance above the threshold of 3.75 mS/cm2. On the other hand, insignificant changes in firing activity are observed when the input conductance is low or close to zero. We thus reproduce Rubin's model with vanishing synaptic conductances. To quantitatively compare spike trains from the original model with the modified model at different conductance levels, we apply four different (dis)similarity measures between them. We observe that Mahalanobis distance, Victor-Purpura metric, and Interspike Interval distribution are sensitive to different firing regimes, whereas Mutual Information seems undiscriminative for these functional changes.

The Neurocognition of Conduct Disorder Behaviors: Specificity to Physical Aggression and Theft After Controlling for ADHD Symptoms

PubMed Central

Barker, Edward D.; Tremblay, Richard E.; van Lier, Pol A.C.; Vitaro, Frank; Nagin, Daniel S.; Assaad, Jean-Marc; Séguin, Jean R.

2012-01-01

There is growing evidence that among the different conduct disorder (CD) behaviors, physical aggression, but not theft, links to low neurocognitive abilities. Specifically, physical aggression has consistently been found to be negatively related to neurocognitive abilities, whereas theft has been shown to be either positively or not related to neurocognition. The specificity of these links needs further examination because attention deficit hyperactivity disorder (ADHD) links to both physical aggression and neurocognitive variation. The development of self-reported physical aggression and theft, from age 11 to 17 years, was studied in a prospective at-risk male cohort via a dual process latent growth curve model. Seven neurocognitive tests at age 20 were regressed on the growth parameters of physical aggression and theft. The links between neurocognition and the growth parameters of physical aggression and theft were adjusted for ADHD symptoms at ages 11 and 15 (parent, child and teacher reports). Results indicated that verbal abilities were negatively related to physical aggression while they were positively associated with theft. However, inductive reasoning was negatively associated with increases in theft across adolescence. Symptoms of ADHD accounted for part of the neurocognitive test links with physical aggression but did not account for the associations with theft. These differences emphasize the importance of examining specific CD behaviors to better understand their neurodevelopmental mechanisms. They also suggest that youth who engage in different levels of physical aggression or theft behaviors may require different preventive and corrective interventions. PMID:21046606

The neurocognition of conduct disorder behaviors: specificity to physical aggression and theft after controlling for ADHD symptoms.

PubMed

Barker, Edward D; Tremblay, Richard E; van Lier, Pol A C; Vitaro, Frank; Nagin, Daniel S; Assaad, Jean-Marc; Séguin, Jean R

2011-01-01

There is growing evidence that among the different conduct disorder (CD) behaviors, physical aggression, but not theft, links to low neurocognitive abilities. Specifically, physical aggression has consistently been found to be negatively related to neurocognitive abilities, whereas theft has been shown to be either positively or not related to neurocognition. The specificity of these links needs further examination because attention deficit hyperactivity disorder (ADHD) links to both physical aggression and neurocognitive variation. The development of self-reported physical aggression and theft, from age 11 to 17 years, was studied in a prospective at-risk male cohort via a dual process latent growth curve model. Seven neurocognitive tests at age 20 were regressed on the growth parameters of physical aggression and theft. The links between neurocognition and the growth parameters of physical aggression and theft were adjusted for ADHD symptoms at ages 11 and 15 (parent, child and teacher reports). Results indicated that verbal abilities were negatively related to physical aggression while they were positively associated with theft. However, inductive reasoning was negatively associated with increases in theft across adolescence. Symptoms of ADHD accounted for part of the neurocognitive test links with physical aggression but did not account for the associations with theft. These differences emphasize the importance of examining specific CD behaviors to better understand their neurodevelopmental mechanisms. They also suggest that youth who engage in different levels of physical aggression or theft behaviors may require different preventive and corrective interventions. © 2010 Wiley-Liss, Inc.

Hydrologic and water-quality data from Mountain Island Lake, North Carolina, 1994-97

USGS Publications Warehouse

Sarver, K.M.; Steiner, B.C.

1998-01-01

Continuous-record water-level gages were established at three sites on Mountain Island Lake and one site downstream from Mountain Island Dam. The water level of Mountain Island Lake is controlled by Duke Power Company releases at Cowans Ford Dam (upstream) and Mountain Island Dam (downstream). Water levels on Mountain Island Lake measured just downstream from Cowans Ford Dam fluctuated 11.15 feet during the study. Water levels just upstream from the Mountain Island Lake forebay fluctuated 6.72 feet during the study. About 3 miles downstream from Mountain Island Dam, water levels fluctuated 5.31 feet. Sampling locations included 14 sites in Mountain Island Lake, plus one downstream river site. At three sites, automated instruments recorded water temperature, dissolved-oxygen concentration, and specific conductance at 15-minute intervals throughout the study. Water temperatures recorded continuously during the study ranged from 4.2 to 35.2 degrees Celsius, and dissolved-oxygen concentrations ranged from 2.1 to 11.8 milligrams per liter. Dissolved-oxygen concentrations generally were inversely related to water temperature, with lowest dissolved-oxygen concentrations typically recorded in the summer. Specific conductance values recorded continuously during the study ranged from 33 to 89 microsiemens per centimeter; however, mean monthly values were fairly consistent throughout the study at all sites (50 to 61 microsiemens per centimeter). In addition, vertical profiles of water temperature, dissolved-oxygen concentration, specific conductance, and pH were measured at all sampling locations during 24 site visits. Water-quality constituent concentrations were determined for seven reservoir sites and the downstream river site during 17 sampling trips. Water-quality samples were routinely analyzed for biochemical oxygen demand, fecal coliform bacteria, hardness, alkalinity, total and volatile suspended solids, nutrients, total organic carbon, chlorophyll, iron, calcium, and magnesium; the samples were analyzed less frequently for trace metals, volatile organic compounds, semivolatile organic compounds, and pesticides. Maximum dissolved nitrite plus nitrate concentrations determined during the study were 0.348 milligram per liter in the mainstem sites and 2.77 milligrams per liter in the coves. Maximum total phosphorus concentrations were 0.143 milligram per liter in the mainstem sites and 0.600 milligram per liter in the coves. Fecal coliform and chlorophyll a concentrations were less than or equal to 160 colonies per 100 milliliters and 13 micrograms per liter, respectively, in all samples. Trace metals detected in at least one sample included arsenic, chromium, copper, lead, nickel, zinc, and antimony. Concentrations of all trace metals (except zinc) were 5.0 micrograms per liter or less; the maximum zinc concentration was 80 micrograms per liter. One set of bottom material samples was collected from Gar Creek and McDowell Creek for chemical analysis and analyzed for nutrients, trace metals, organochlorine pesticides, and semivolatile organic compounds. The only organochlorine pesticide identified in either sample was p,p'-DDE at an estimated concentration of 0.8 microgram per kilogram. Twenty semivolatile organic compounds, mainly polyaromatic hydrocarbons and plasticizers, were identified.

Facilitated patient experience feedback can improve nursing care: a pilot study for a phase III cluster randomised controlled trial

PubMed Central

2013-01-01

Background England’s extensive NHS patient survey programme has not fulfilled government promises of widespread improvements in patients’ experiences, and media reports of poor nursing care in NHS hospitals are increasingly common. Impediments to the surveys’ impact on the quality of nursing care may include: the fact that they are not ward-specific, so nurses claim “that doesn’t happen on my ward”; nurses’ scepticism about the relevance of patient feedback to their practice; and lack of prompt communication of results. The surveys’ impact could be increased by: conducting ward-specific surveys; returning results to ward staff more quickly; including patients’ written comments in reports; and offering nurses an opportunity to discuss the feedback. Very few randomised trials have been conducted to test the effectiveness of patient feedback on quality improvement and there have been few, if any, published trials of ward-specific patient surveys. Methods Over two years, postal surveys of recent inpatients were conducted at four-monthly intervals in 18 wards in two NHS Trusts in England. Wards were randomly allocated to Basic Feedback (ward-specific printed patient survey results including patients’ written comments sent to nurses by letter); Feedback Plus (in addition to printed results, ward meetings to discuss results and plan improvements) or Control (no active feedback of survey results). Patient survey responses to questions about nursing care were used to compute wards’ average Nursing Care Scores at each interval. Nurses’ reactions to the patient feedback were recorded. Results Conducting ward-level surveys and delivering ward-specific results was feasible. Ward meetings were effective for engaging nurses and challenging scepticism and patients’ written comments stimulated interest. 4,236 (47%) patients returned questionnaires. Nursing Care Scores improved more for Feedback Plus than Basic Feedback or Control (difference between Control and Feedback Plus = 8.28 ± 7.2 (p = 0.02)). Conclusions This study provides preliminary evidence that facilitated patient feedback can improve patients’ experiences such that a full trial is justified. These findings suggest that merely informing nurses of patient survey results in writing does not stimulate improvements, even if results are disaggregated by ward, but the addition of ward meetings had an important and significant impact. PMID:23826970

Evaluation of basal sex hormone levels for activation of the hypothalamic-pituitary-gonadal axis.

PubMed

Ding, Yu; Li, Juan; Yu, Yongguo; Yang, Peirong; Li, Huaiyuan; Shen, Yongnian; Huang, Xiaodong; Liu, Shijian

2018-03-28

This study aimed to identify the predictive value of basal sex hormone levels for activation of the hypothalamic-pituitary-gonadal (HPG) axis in girls. Gonadotropin-releasing hormone (GnRH) stimulation tests were performed and evaluated in a total of 1750 girls with development of secondary sex characteristics. Correlation analyses were conducted between basal sex hormones and peak luteinizing hormone (LH) levels ≥5 IU/L during the GnRH stimulation test. Receiver operating characteristic (ROC) curves for basal levels of LH, follicle-stimulating hormone (FSH), LH/FSH, and estradiol (E2) before the GnRH stimulation test were plotted. The area under the curve (AUC) and 95% confidence intervals (CIs) were measured for each curve. The maximum AUC value was observed for basal LH levels (0.77, 95% CI: 0.74-0.79), followed by basal FSH levels (0.73, 95% CI: 0.70-0.75), the basal LH/FSH ratio (0.68, 95% CI: 0.65-0.71), and basal E2 levels (0.61, 95% CI: 0.59-0.64). The appropriate cutoff value of basal LH levels associated with a positive response of the GnRH stimulation test was 0.35 IU/L, with a sensitivity of 63.96% and specificity of 76.3% from the ROC curves when Youden's index showed the maximum value. When 100% of patients had peak LH levels ≥5 IU/L, basal LH values were >2.72 IU/L, but the specificity was only 5.45%. Increased basal LH levels are a significant predictor of a positive response during the GnRH stimulation test for assessing activation of the HPG axis in most girls with early pubertal signs.

Effect of dietary choline levels on growth performance, lipid deposition and metabolism in juvenile yellow catfish Pelteobagrus fulvidraco.

PubMed

Luo, Zhi; Wei, Chuan-Chuan; Ye, Han-Mei; Zhao, Hai-Ping; Song, Yu-Feng; Wu, Kun

2016-12-01

The present experiment was conducted to determine the effect and mechanism of dietary choline levels on growth performance and lipid deposition of yellow catfish Pelteobagrus fulvidraco. Dietary choline was included at three levels of 239.2 (control (without extra choline addition), 1156.4 and 2273.6mg choline per kg diet, respectively) and fed to yellow catfish (mean initial weight: 3.45±0.02g mean±standard errors of mean (SEM)) for 8weeks. Fish fed the diet containing 1156.4mgkg -1 choline showed the higher weight gain (WG), specific growth rate (SGR) and feed intake (FI), but the lower feed conversion rate (FCR), than those in control and highest choline group. Hepatosomatic index (HSI) and hepatic lipid content declined with increasing dietary choline levels. Muscle lipid content was the lowest for fish fed adequate choline diets and showed no significant difference between other two groups. Choline contents in liver and muscle increased with increasing dietary choline levels. Dietary choline levels significantly influenced mRNA levels of genes involved in lipid homeostasis in muscle and liver, such as CTP:phosphocholine cytidylyltransferase a (CCTa), phosphatidylethanolamine N-methyl-transferase (PEMT), microsomal triglyceride transfer protein (MTP), apolipoprotein b (APOBb), apolipoprotein E (ApoE) and lipoprotein lipase (LPL), and effects of dietary choline levels on lipid deposition and metabolism were tissue-specific. Different responses of these genes at the mRNA levels partially explained the profiles of lipid deposition in liver and muscle for fish fed different choline diets. To our knowledge, this is the first to explore the effect of dietary choline level on mRNA expression of these genes, which provides new insights into choline nutrition in fish. Copyright © 2016 Elsevier Inc. All rights reserved.

Simulation of Water Levels and Salinity in the Rivers and Tidal Marshes in the Vicinity of the Savannah National Wildlife Refuge, Coastal South Carolina and Georgia

USGS Publications Warehouse

Conrads, Paul; Roehl, Edwin A.; Daamen, Ruby C.; Kitchens, Wiley M.

2006-01-01

The Savannah Harbor is one of the busiest ports on the East Coast of the United States and is located downstream from the Savannah National Wildlife Refuge, which is one of the Nation?s largest freshwater tidal marshes. The Georgia Ports Authority and the U.S. Army Corps of Engineers funded hydrodynamic and ecological studies to evaluate the potential effects of a proposed deepening of Savannah Harbor as part of the Environmental Impact Statement. These studies included a three-dimensional (3D) model of the Savannah River estuary system, which was developed to simulate changes in water levels and salinity in the system in response to geometry changes as a result of the deepening of Savannah Harbor, and a marsh-succession model that predicts plant distribution in the tidal marshes in response to changes in the water-level and salinity conditions in the marsh. Beginning in May 2001, the U.S. Geological Survey entered into cooperative agreements with the Georgia Ports Authority to develop empirical models to simulate the water level and salinity of the rivers and tidal marshes in the vicinity of the Savannah National Wildlife Refuge and to link the 3D hydrodynamic river-estuary model and the marsh-succession model. For the development of these models, many different databases were created that describe the complexity and behaviors of the estuary. The U.S. Geological Survey has maintained a network of continuous streamflow, water-level, and specific-conductance (field measurement to compute salinity) river gages in the study area since the 1980s and a network of water-level and salinity marsh gages in the study area since 1999. The Georgia Ports Authority collected water-level and salinity data during summer 1997 and 1999 and collected continuous water-level and salinity data in the marsh and connecting tidal creeks from 1999 to 2002. Most of the databases comprise time series that differ by variable type, periods of record, measurement frequency, location, and reliability. Understanding freshwater inflows, tidal water levels, and specific conductance in the rivers and marshes is critical to enhancing the predictive capabilities of a successful marsh succession model. Data-mining techniques, including artificial neural network (ANN) models, were applied to address various needs of the ecology study and to integrate the riverine predictions from the 3D model to the marsh-succession model. ANN models were developed to simulate riverine water levels and specific conductance in the vicinity of the tidal marshes for the full range of historical conditions using data from the river gaging networks. ANN models were also developed to simulate the marsh water levels and pore-water salinities using data from the marsh gaging networks. Using the marsh ANN models, the continuous marsh network was hindcasted to be concurrent with the long-term riverine network. The hindcasted data allow ecologists to compute hydrologic parameters?such as hydroperiods and exposure frequency?to help analyze historical vegetation data. To integrate the 3D hydrodynamic model, the marsh-succession model, and various time-series databases, a decision support system (DSS) was developed to support the various needs of regulatory and scientific stakeholders. The DSS required the development of a spreadsheet application that integrates the database, 3D hydrodynamic model output, and ANN riverine and marsh models into a single package that is easy to use and can be readily disseminated. The DSS allows users to evaluate water-level and salinity response for different hydrologic conditions. Savannah River streamflows can be controlled by the user as constant flow, a percentage of historical flows, a percentile daily flow hydrograph, or as a user-specified hydrograph. The DSS can also use output from the 3D model at stream gages near the Savannah National Wildlife Refuge to simulate the effects in the tidal marshes. The DSS is distributed with a two-dimensional (

Resonant tunneling IR detectors

NASA Technical Reports Server (NTRS)

Woodall, Jerry M.; Smith, T. P., III

1990-01-01

Researchers propose a novel semiconductor heterojunction photodetector which would have a very low dark current and would be voltage tunable. A schematic diagram of the device and its band structure are shown. The two crucial components of the device are a cathode (InGaAs) whose condition band edge is below the conduction band edge of the quantum wells and a resonant tunneling filter (GaAs-AlGaAs). In a standard resonant tunneling device the electrodes are made of the same material as the quantum wells, and this device becomes highly conducting when the quantum levels in the wells are aligned with the Fermi level in the negatively biased electrode. In contrast, the researchers device is essentially non-conducting under the same bias conditions. This is because the Fermi Level of the cathode (InGaAs) is still well below the quantum levels so that no resonant transport occurs and the barriers (AlGaAs) effectively block current flow through the device. However, if light with the same photon energy as the conduction-band discontinuity between the cathode and the quantum wells, E sub c3-E sub c1, is shone on the sample, free carriers will be excited to an energy corresponding to the lowest quantum level in the well closest to the cathode (hv plue E sub c1 = E sub o). These electrons will resonantly tunnel through the quantum wells and be collected as a photocurrent in the anode (GaAs). To improve the quantum efficiency, the cathode (InGaAs) should be very heavily doped and capped with a highly reflective metal ohmic contact. The thickness of the device should be tailored to optimize thin film interference effects and afford the maximum absorption of light. Because the device relies on resonant tunneling, its response should be very fast, and the small voltages needed to change the responsivity should allow for very high frequency modulation of the photocurrent. In addition, the device is tuned to a specific photon energy so that it can be designed to detect a fairly narrow range of wavelengths. This selectivity is important for reducing the photocurrent due to spurious light sources.

Impact of human development on safety consciousness in construction.

PubMed

Baradan, Selim; Dikmen, Seyyit Umit; Akboga Kale, Ozge

2018-05-03

The International Labour Organization (ILO) reports that the risk of fatal occupational injuries in developing countries is almost twice as high as in developed countries, indicating a potential relationship between the fatality rates and the development level. The human development index (HDI), based on life expectancy, knowledge level and purchasing power parity, endorsed by the United Nations Development Programme, is a widely accepted measure of the development level. This study investigates the relationship between the HDI and the fatality rates reported by the ILO. A 23-country data set is used to demonstrate the general trend of the relationship followed by country-specific analyses for Australia, Spain, Hungary and Turkey. The study conducted is limited to fatal occupational injuries in construction, where the accidents are notoriously high. The results demonstrate a statistically significant inverse relationship between the fatality rates and the HDI.

Effects of background noise on total noise annoyance

NASA Technical Reports Server (NTRS)

Willshire, K. F.

1987-01-01

Two experiments were conducted to assess the effects of combined community noise sources on annoyance. The first experiment baseline relationships between annoyance and noise level for three community noise sources (jet aircraft flyovers, traffic and air conditioners) presented individually. Forty eight subjects evaluated the annoyance of each noise source presented at four different noise levels. Results indicated the slope of the linear relationship between annoyance and noise level for the traffic noise was significantly different from that of aircraft and of air conditioner noise, which had equal slopes. The second experiment investigated annoyance response to combined noise sources, with aircraft noise defined as the major noise source and traffic and air conditioner noise as background noise sources. Effects on annoyance of noise level differences between aircraft and background noise for three total noise levels and for both background noise sources were determined. A total of 216 subjects were required to make either total or source specific annoyance judgements, or a combination of the two, for a wide range of combined noise conditions.

Health education for a breast and cervical cancer screening program: using the ecological model to assess local initiatives.

PubMed

Holden, D J; Moore, K S; Holliday, J L

1998-06-01

This study investigates the development and implementation of health education strategies at the local level for a statewide breast and cervical cancer control program. Baseline data on these initiatives were collected from 88 local screening programs in North Carolina. Using the ecological model as a framework, health education initiatives were assessed and analyzed to determine the level of activity occurring at the local level and the comprehensiveness of programs. Types and levels of interventions used are described and initial analysis is provided of the impact these strategies are having on recruiting women from target populations into these screening programs. Specific examples illustrating the variety of interventions used at the individual, network, organizational and community levels, and the impact of certain variables, such as the use of local health education staff, on the comprehensiveness of interventions utilized, are provided. The importance to practitioners of establishing process indicators in assessing local initiatives and challenges to conducting evaluations of these strategies are also discussed.

Inhibition of electron thermal conduction by electromagnetic instabilities. [in stellar coronas

NASA Technical Reports Server (NTRS)

Levinson, Amir; Eichler, David

1992-01-01

Heat flux inhibition by electromagnetic instabilities in a hot magnetized plasma is investigated. Low-frequency electromagnetic waves become unstable due to anisotropy of the electron distribution function. The chaotic magnetic field thus generated scatters the electrons with a specific effective mean free path. Saturation of the instability due to wave-wave interaction, nonlinear scattering, wave propagation, and collisional damping is considered. The effective mean free path is found self-consistently, using a simple model to estimate saturation level and scattering, and is shown to decrease with the temperature gradient length. The results, limited to the assumptions of the model, are applied to astrophysical systems. For some interstellar clouds the instability is found to be important. Collisional damping stabilizes the plasma, and the heat conduction can be dominated by superthermal electrons.

Organizational cultural competence in community health and social service organizations: how to conduct a self-assessment.

PubMed

Olavarria, Marcela; Beaulac, Julie; Bélanger, Alexandre; Young, Marta; Aubry, Tim

2009-01-01

In an effort to address the significant socio-cultural changes in the population demographics of the United States (US) and Canada, organizations are increasingly seeking ways of improving their level of cultural competence. Evaluating organizational cultural competence is essential to address the needs of ethnic and cultural minorities. Yet, research related to organizational cultural competence is relatively new. The purpose of this paper is to review the extant literature with a specific focus on: (1) identifying the key standards that define culturally competent community health and social service organizations; and (2) outlining the core elements for evaluating cultural competence in a health and social service organization. Furthermore, issues related to choosing self-assessment tools and conducting an evaluation will be explored.

Specific heat and thermal conductivity of nanomaterials

NASA Astrophysics Data System (ADS)

Bhatt, Sandhya; Kumar, Raghuvesh; Kumar, Munish

2017-01-01

A model is proposed to study the size and shape effects on specific heat and thermal conductivity of nanomaterials. The formulation developed for specific heat is based on the basic concept of cohesive energy and melting temperature. The specific heat of Ag and Au nanoparticles is reported and the effect of size and shape has been studied. We observed that specific heat increases with the reduction of particle size having maximum shape effect for spherical nanoparticle. To provide a more critical test, we extended our model to study the thermal conductivity and used it for the study of Si, diamond, Cu, Ni, Ar, ZrO2, BaTiO3 and SrTiO3 nanomaterials. A significant reduction is found in the thermal conductivity for nanomaterials by decreasing the size. The model predictions are consistent with the available experimental and simulation results. This demonstrates the suitability of the model proposed in this paper.

Certain Less Invasive Infertility Treatments Associated with Different Levels of Pregnancy-Related Anxiety in Pregnancies Conceived via In Vitro Fertilization.

PubMed

Stevenson, Eleanor Lowndes; Sloane, Richard

2017-01-01

Research supports that in vitro fertilization causes anxiety and that anxiety can continue into the resulting pregnancy. Most women who have IVF will have a less invasive treatment for infertility prior to IVF; however, it is unclear if specific less invasive treatment cycles impact anxiety that is experienced in the pregnancy resulting from IVF. A prospective study was conducted for women who became pregnant via IVF, and data was collected about reported previous non-IVF treatment cycles as well as Pregnancy Related Anxiety Measure. Latent Class Analysis was conducted A p-value of ≤0.05 was considered significant. 144 subjects participated and were highly educated, affluent, married, and primarily white. The LCA process yielded two groups that on average had similar levels on most items except for use of intra uterine insemination and/or ovarian stimulation. This information was used to generate four exhaustive and mutually exclusive groups: Stimulation Only (stim-only), Stimulation and Intra uterine Insemination (stim-IUI), Intra uterine Insemination only (IUI only), or No Treatment (No Tx). ANOVA found that those in the Stim Only group had statistically significantly higher PRAM scores than the Stim IUI (p=0.0036), the IUI only group (p=0.05), and the No Tx group (p=0.0013). Women who become pregnant via IVF and had a history of non- in vitro fertilization cycles that only involved ovarian stimulation experienced more pregnancy-specific anxiety in the pregnancy that results from in vitro fertilization.

The relation of ground-water quality to housing density, Cape Cod, Massachusetts

USGS Publications Warehouse

Persky, J.H.

1986-01-01

Correlation of median nitrate concentration in groundwater with housing density for 18 sample areas on Cape Cod yields a Pearson correlation coefficient of 0.802, which is significant at the 95 % confidence level. In five of nine sample areas where housing density is greater than one unit/acre, nitrate concentrations exceed 5 mg of nitrate/L (the Barnstable County planning goal for nitrate) in 25% of wells. Nitrate concentrations exceed 5 mg of nitrogen/L in 25% of wells in only one of nine sample areas where housing density is less than one unit/acre. Median concentrations of sodium and iron, and median levels of pH and specific conductance, are not significantly correlated with housing density. A computer generated map of nitrate shows a positive relation between nitrate concentration and housing density on Cape Cod. However, the presence of septage- or sewage-disposal sites and fertilizer use are also important factors that affect the nitrate concentration. A map of specific conductance also shows a positive relation to housing density, but little or no relation between housing density and sodium, ammonia, pH, or iron is apparent on the maps. Chemical analyses of samples collected from 3,468 private- and public-supply wells between January 1980 and June 1984 were used to examine the extent to which housing density determines water quality on Cape Cod, an area largely unsewered and underlain by a sole source aquifer. (Author 's abstract)

Team Composition Issues for Future Space Exploration: A Review and Directions for Future Research.

PubMed

Bell, Suzanne T; Brown, Shanique G; Abben, Daniel R; Outland, Neal B

2015-06-01

Future space exploration, such as a mission to Mars, will require space crews to live and work in extreme environments unlike those of previous space missions. Extreme conditions such as prolonged confinement, isolation, and expected communication time delays will require that crews have a higher level of interpersonal compatibility and be able to work autonomously, adapting to unforeseen challenges in order to ensure mission success. Team composition, or the configuration of member attributes, is an important consideration for maximizing crewmember well-being and team performance. We conducted an extensive search to find articles about team composition in long-distance space exploration (LDSE)-analogue environments, including a search of databases, specific relevant journals, and by contacting authors who publish in the area. We review the team composition research conducted in analogue environments in terms of two paths through which team composition is likely to be related to LDSE mission success, namely by 1) affecting social integration, and 2) the team processes and emergent states related to team task completion. Suggestions for future research are summarized as: 1) the need to identify ways to foster unit-level social integration within diverse crews; 2) the missed opportunity to use team composition variables as a way to improve team processes, emergent states, and task completion; and 3) the importance of disentangling the effect of specific team composition variables to determine the traits (e.g., personality, values) that are associated with particular risks (e.g., subgrouping) to performance.

Socioeconomic disparities in osteoporosis prevalence: different results in the overall Korean adult population and single-person households.

PubMed

Kim, Jungmee; Lee, Joongyub; Shin, Ju-Young; Park, Byung-Joo

2015-03-01

The present study was conducted in order to examine the association between socioeconomic status (SES) and osteoporosis prevalence in Korea and to assess whether different associations are found in single-person households. A cross-sectional population-based study was conducted using the Korea National Health and Nutrition Examination Survey, from 2008 to 2011. The study subjects were people aged ≥ 50 years with osteoporosis as defined by bone mineral density. Multivariate logistic models were used to estimate prevalence odds ratios (pORs) and 95% confidence intervals (CIs). Gender differences in the likelihood of osteoporosis were analyzed based on household income, education level, and residential area. There were 8221 osteoporosis patients aged ≥ 50 years, of whom 927 lived in single-person households. There was a gender-specific association between osteoporosis prevalence and all three SES factors that we analyzed: income, education, and residential area. After adjusting for age, SES, and health behaviors, including body mass index (BMI), low household income was only significantly associated with osteoporosis in men, whereas education level had an inverse relationship with osteoporosis only in women (p = 0.01, p < 0.001, respectively). However, after controlling for age and BMI, rural residency was only associated with osteoporosis in women living in single-person households (pOR, 1.59; 95% CI, 1.05 to 2.43). The Korean adult population showed a gender-specific relationship between SES and osteoporosis prevalence, with a different pattern found in single-person households.

[Diagnosis and venom specific immunotherapy (VIT) in allergic children in Poland--how much the current practice follows the international guidelines?].

PubMed

Cichocka-Jarosz, Ewa; Brzyski, Piotr; Lis, Grzegorz; Jedynak-Wasowicz, Urszula; Pietrzyk, Jacek Józef; Lange, Joanna; Małaczyńska, Teresa; Kraluk, Barbara; Swiebocka, Ewa; Breborowicz, Anna; Kycler, Zdzisława; Pietraszek-Mamcarz, Jolanta; Poszwiński, Adam; Gaszczyk, Grzegorz

2010-01-01

Insect venom allergy requires a high level approach adequate to allergy intensity. In case of severe IgE-mediated sting reactions, in children older than five years, venom immunotherapy is a treatment of choice. Identification of current practices applied to venom allergic children in Poland and their adherence to the international guidelines. Questionnaire survey concerning diagnostic and treatment rules was carried out in 8 centres of pediatric allergology, based on a similar audit conducted in the United Kingdom [Diwakar L. et al. Clin Exp Allergy 2008, 38: 1651]. In 5 centres both RAST and SPT tests were used as the first line of investigation. Subsequently 6 centres performed IDT. In three centres baseline serum tryptase levels were estimated. In case of sensitization to both bee and wasp venom in a child with the history of severe systemic reaction, but uncertain culprit insect, specific venom immunotherapy with both venoms was practised by 2 centres. In systemic reaction and not-detectable IgE in 6 centres child was followed-up in 6-12 months. Antihistamine premedication concerned all children in 7 centres. Six-week interval between booster doses was applied in half of centres. A target dose equal 100 mcg was used in 7 centres. Similarly all centres practiced 3-5 five year period of VIT. In Poland current practice with venom allergic children was conducted in congruence with most of the recommendations.