Science.gov

Sample records for lh pulse frequency

  1. Accumulated deep sleep is a powerful predictor of LH pulse onset in pubertal children.

    PubMed

    Shaw, N D; Butler, J P; Nemati, S; Kangarloo, T; Ghassemi, M; Malhotra, A; Hall, J E

    2015-03-01

    During puberty, reactivation of the reproductive axis occurs during sleep, with LH pulses specifically tied to deep sleep. This association suggests that deep sleep may stimulate LH secretion, but there have been no interventional studies to determine the characteristics of deep sleep required for LH pulse initiation. The objective of this study was to determine the effect of deep sleep fragmentation on LH secretion in pubertal children. Studies were performed in a clinical research center. Fourteen healthy pubertal children (11.3-14.1 y) participated in the study. Subjects were randomized to two overnight studies with polysomnography and frequent blood sampling, with or without deep sleep disruption via auditory stimuli. An average of 68.1 ±10.7 (± SE) auditory stimuli were delivered to interrupt deep sleep during the disruption night, limiting deep sleep to only brief episodes (average length disrupted 1.3 ± 0.2 min vs normal 7.1 ± 0.8 min, P < .001), and increasing the number of transitions between non-rapid eye movement (NREM), REM, and wake (disrupted 274.5 ± 33.4 vs normal 131.2 ± 8.1, P = .001). There were no differences in mean LH (normal: 3.2 ± 0.4 vs disrupted: 3.2 ± 0.5 IU/L), LH pulse frequency (0.6 ± 0.06 vs 0.6 ± 0.07 pulses/h), or LH pulse amplitude (2.8 ± 0.4 vs 2.8 ± 0.4 IU/L) between the two nights. Poisson process modeling demonstrated that the accumulation of deep sleep in the 20 minutes before an LH pulse, whether consolidated or fragmented, was a significant predictor of LH pulse onset (P < .001). In pubertal children, nocturnal LH augmentation and pulse patterning are resistant to deep sleep fragmentation. These data suggest that, even when fragmented, deep sleep is strongly related to activation of the GnRH pulse generator.

  2. Accumulated Deep Sleep Is a Powerful Predictor of LH Pulse Onset in Pubertal Children

    PubMed Central

    Butler, J. P.; Nemati, S.; Kangarloo, T.; Ghassemi, M.; Malhotra, A.; Hall, J. E.

    2015-01-01

    Context: During puberty, reactivation of the reproductive axis occurs during sleep, with LH pulses specifically tied to deep sleep. This association suggests that deep sleep may stimulate LH secretion, but there have been no interventional studies to determine the characteristics of deep sleep required for LH pulse initiation. Objective: The objective of this study was to determine the effect of deep sleep fragmentation on LH secretion in pubertal children. Design and Setting: Studies were performed in a clinical research center. Subjects: Fourteen healthy pubertal children (11.3–14.1 y) participated in the study. Interventions: Subjects were randomized to two overnight studies with polysomnography and frequent blood sampling, with or without deep sleep disruption via auditory stimuli. Results: An average of 68.1 ±10.7 (± SE) auditory stimuli were delivered to interrupt deep sleep during the disruption night, limiting deep sleep to only brief episodes (average length disrupted 1.3 ± 0.2 min vs normal 7.1 ± 0.8 min, P < .001), and increasing the number of transitions between non-rapid eye movement (NREM), REM, and wake (disrupted 274.5 ± 33.4 vs normal 131.2 ± 8.1, P = .001). There were no differences in mean LH (normal: 3.2 ± 0.4 vs disrupted: 3.2 ± 0.5 IU/L), LH pulse frequency (0.6 ± 0.06 vs 0.6 ± 0.07 pulses/h), or LH pulse amplitude (2.8 ± 0.4 vs 2.8 ± 0.4 IU/L) between the two nights. Poisson process modeling demonstrated that the accumulation of deep sleep in the 20 minutes before an LH pulse, whether consolidated or fragmented, was a significant predictor of LH pulse onset (P < .001). Conclusion: In pubertal children, nocturnal LH augmentation and pulse patterning are resistant to deep sleep fragmentation. These data suggest that, even when fragmented, deep sleep is strongly related to activation of the GnRH pulse generator. PMID:25490277

  3. GnRH pulse frequency differentially regulates steroidogenic factor 1 (SF1), dosage-sensitive sex reversal-AHC critical region on the X chromosome gene 1 (DAX1), and serum response factor (SRF): potential mechanism for GnRH pulse frequency regulation of LH beta transcription in the rat.

    PubMed

    Burger, Laura L; Haisenleder, Daniel J; Marshall, John C

    2011-06-01

    The issue of how rapid frequency GnRH pulses selectively stimulate LH transcription is not fully understood. The rat LHβ promoter contains two GnRH-responsive regions: the proximal region has binding elements for SF1, and the distal site contains a CArG box, which binds SRF. This study determined whether GnRH stimulates pituitary SF1, DAX1 (an endogenous SF1 inhibitor), and SRF transcription in vivo, and whether regulation is frequency dependent. Male rats were pulsed with 25 ng GnRH i.v. every 30 min or every 240 min for 1-24 h, and primary transcripts (PTs) and mRNAs were measured by real time PCR. Fast frequency GnRH pulses (every 30 min) increased SF1 PT (threefold) within 1 h, and then declined after 6 h. SF1 mRNA also increased within 1 h and remained elevated through 24 h. Fast frequency GnRH also stimulated a transient increase in DAX1 PT (twofold after 1 h) and mRNA (1.7-fold after 6 h), while SRF mRNA rose briefly at 1 h. Slow frequency pulses did not affect gene expression of SF1, DAX1, or SRF. These findings support a mechanistic link between SF1 in the frequency regulation of LHβ transcription by pulsatile GnRH.

  4. Effect of exogenous LH pulses on the fate of the first dominant follicle in postpartum beef cows nursing calves.

    PubMed

    Duffy, P; Crowe, M A; Boland, M P; Roche, J F

    2000-01-01

    Prolonged postpartum anoestrus in beef cows is due to failure of early dominant follicles to ovulate. It is hypothesized that this failure to ovulate is due to inadequate LH pulse frequency. The objective of this study was to determine whether administration of hourly LH pulses would cause the first dominant follicle to ovulate. In Expt 1, 16 cows received either saline (n = 8) or porcine LH (pLH; 50 micrograms h-1; n = 8) as hourly pulses for 3-5 days from the second day of dominance of the first dominant follicle (day 0). In Expt 2, 21 cows received either saline (n = 7), or 50 micrograms pLH (n = 7) or 100 micrograms pLH (n = 7) as hourly pulses for 3 days. Appropriate ovarian scanning and assays of blood samples were carried out. In Expt 1, the number of dominant follicles that underwent atresia was not affected by increasing the number of LH pulses, but the duration of dominance (days) of the first and second dominant follicles and maximum size (mm) of the second dominant follicle were increased (P < 0.05). Oestradiol concentrations were higher (P < 0.05) in cows given hourly pLH pulses (3.1 +/- 1.2 pg ml-1) compared with controls (1.2 +/- 0.2 pg ml-1). Four of eight treated cows had an anovulatory LH surge. The number of follicle waves to first ovulation was not different (P < 0.05) between control (4.6 +/- 0.9) and pLH treated cows (3.9 +/- 0.5). In Expt 2, four of seven cows given pulses of 100 micrograms pLH h-1 ovulated the first dominant follicle, and the interval from calving to first ovulation was decreased (P < 0.05). In the remaining three cows, the duration of dominance of the first dominant follicle was increased (P < 0.005), the maximum size of the first dominant follicle was greater (P < 0.05), and the interval (days) from the start of infusion to new wave emergence was greater (P < 0.05) compared with cows that failed to ovulate in either the 50 micrograms pLH h-1 or control treatments. In conclusion, hourly pulses of pLH from day 1 after

  5. Prenatal exposure to androgen excess increases LH pulse amplitude during postnatal life in male sheep.

    PubMed

    Recabarren, S E; Recabarren, M; Rojas-Garcia, P P; Cordero, M; Reyes, C; Sir-Petermann, T

    2012-09-01

    Prenatal exposure to excess testosterone has a profound impact on reproductive and metabolic functions in young and adult female sheep. Nevertheless, few studies have addressed the impact of prenatal exposure to an excess of androgens on reproductive and metabolic functions in males. The aim of the present study was to assess the impact of prenatal exposure to an excess of testosterone or dihydrotestosterone on the luteinizing hormone (LH) pulse characteristics during sexual development in male sheep. Control male sheep (C-males) and males born to mothers exposed to twice weekly injections of 30 mg testosterone or dihydrotestosterone from day 30-90 and 40 mg from day 90-120 of gestation (T-males, DHT-males) were studied at 5, 10, and 20 weeks of age, ages that represent infancy, early prepubertal, and late prepubertal stages of sexual development in this species, respectively. Patterns of LH pulsatility showed that T- and DHT-males exhibited a higher secretion of LH during the 6-h study and a higher amplitude of the LH pulses compared with C-males. Moreover, nadir of the pulses was higher in T- and DHT-males compared with C-males. Frequency of LH pulses, however, was not different within ages or between groups. These results show that males can be responsive to prenatal androgenization and suggest that treatment transiently alters the amplitude of LH pulses probably as the result of defects in the pituitary responsiveness pattern or in the gonadotropin-releasing hormone (GnRH) release pattern.

  6. High frequency pulsed electromigration

    NASA Astrophysics Data System (ADS)

    Malone, David Wayne

    Electromigration life tests were performed on copper-alloyed aluminum test structures that were representative of modern CMOS metallization schemes, complete with Ti/TiN cladding layers and a tungsten-plug contact at the cathode. A total of 18 electrical stress treatments were applied. One was a DC current of 15 mA. The other 17 were pulsed currents, varied according to duty cycle and frequency. The pulse amplitude was 15 mA (˜2.7 × 10sp6 A/cmsp2) for all treatments. Duty cycles ranged from 33.3% to 80%, and frequencies fell into three rough ranges-100 KHz, 1 MHz, and 100 MHz. The ambient test temperature was 200sp°C in all experiments. Six to 9 samples were subjected to each treatment. Experimental data were gathered in the form of test stripe resistance versus time, R(t). For purposes of lifetime analysis, "failure" was defined by the criterion R(t)/R(0) = 1.10, and the median time to failure, tsb{50}, was used as the primary basis of comparison between test groups. It was found that the dependence of tsb{50} on pulse duty cycle conformed rather well to the so-called "average current density model" for duty cycles of 50% and higher. Lifetimes were less enhanced for a duty cycle of 33.3%, but they were still considerably longer than an "on-time" model would predict. No specific dependence of tsb{50} on pulse frequency was revealed by the data, that is, reasonably good predictions of tsb{50} could be made by recognizing the dominant influence of duty cycle. These findings confirm that IC miniaturization can be more aggressively pursued than an on-time prediction would allow. It is significant that this was found to be true for frequencies on the order of 100 MHz, where many present day digital applications operate. Post-test optical micrographs were obtained for each test subject in order to determine the location of electromigration damage. The pulse duty cycle was found to influence the location. Most damage occurred at the cathode contact, regardless of

  7. DynPeak: An Algorithm for Pulse Detection and Frequency Analysis in Hormonal Time Series

    PubMed Central

    Vidal, Alexandre; Zhang, Qinghua; Médigue, Claire; Fabre, Stéphane; Clément, Frédérique

    2012-01-01

    The endocrine control of the reproductive function is often studied from the analysis of luteinizing hormone (LH) pulsatile secretion by the pituitary gland. Whereas measurements in the cavernous sinus cumulate anatomical and technical difficulties, LH levels can be easily assessed from jugular blood. However, plasma levels result from a convolution process due to clearance effects when LH enters the general circulation. Simultaneous measurements comparing LH levels in the cavernous sinus and jugular blood have revealed clear differences in the pulse shape, the amplitude and the baseline. Besides, experimental sampling occurs at a relatively low frequency (typically every 10 min) with respect to LH highest frequency release (one pulse per hour) and the resulting LH measurements are noised by both experimental and assay errors. As a result, the pattern of plasma LH may be not so clearly pulsatile. Yet, reliable information on the InterPulse Intervals (IPI) is a prerequisite to study precisely the steroid feedback exerted on the pituitary level. Hence, there is a real need for robust IPI detection algorithms. In this article, we present an algorithm for the monitoring of LH pulse frequency, basing ourselves both on the available endocrinological knowledge on LH pulse (shape and duration with respect to the frequency regime) and synthetic LH data generated by a simple model. We make use of synthetic data to make clear some basic notions underlying our algorithmic choices. We focus on explaining how the process of sampling affects drastically the original pattern of secretion, and especially the amplitude of the detectable pulses. We then describe the algorithm in details and perform it on different sets of both synthetic and experimental LH time series. We further comment on how to diagnose possible outliers from the series of IPIs which is the main output of the algorithm. PMID:22802933

  8. Role of estradiol in cortisol-induced reduction of luteinizing hormone pulse frequency.

    PubMed

    Oakley, Amy E; Breen, Kellie M; Tilbrook, Alan J; Wagenmaker, Elizabeth R; Karsch, Fred J

    2009-06-01

    Precise control of pulsatile GnRH and LH release is imperative to ovarian cyclicity but is vulnerable to environmental perturbations, like stress. In sheep, a sustained (29 h) increase in plasma cortisol to a level observed during stress profoundly reduces GnRH pulse frequency in ovariectomized ewes treated with ovarian steroids, whereas shorter infusion (6 h) is ineffective in the absence of ovarian hormones. This study first determined whether the ovarian steroid milieu or duration of exposure is the relevant factor in determining whether cortisol reduces LH pulse frequency. Prolonged (29 h) cortisol infusion did not lower LH pulse frequency in ovariectomized ewes deprived of ovarian hormones, but it did so in ovariectomized ewes treated with estradiol and progesterone to create an artificial estrous cycle, implicating ovarian steroids as the critical factor. Importantly, this effect of cortisol was more pronounced after the simulated preovulatory estradiol rise of the artificial follicular phase. The second experiment examined which component of the ovarian steroid milieu enables cortisol to reduce LH pulse frequency in the artificial follicular phase: prior exposure to progesterone in the luteal phase, low early follicular phase estradiol levels, or the preovulatory estradiol rise. Basal estradiol enabled cortisol to decrease LH pulse frequency, but the response was potentiated by the estradiol rise. These findings lead to the conclusion that ovarian steroids, particularly estradiol, enable cortisol to inhibit LH pulse frequency. Moreover, the results provide new insight into the means by which gonadal steroids, and possibly reproductive status, modulate neuroendocrine responses to stress.

  9. Pulsed optically pumped frequency standard

    SciTech Connect

    Godone, Aldo; Micalizio, Salvatore; Levi, Filippo

    2004-08-01

    We reconsider the idea of a pulsed optically pumped frequency standard conceived in the early 1960s to eliminate the light-shift effect. The development of semiconductor lasers and of pulsed electronic techniques for atomic fountains and new theoretical findings allow an implementation of this idea which may lead to a frequency standard whose frequency stability is limited only by the thermal noise in the short term and by the temperature drift in the long term. We shall also show both theoretically and experimentally the possibility of doubling the atomic quality factor with respect to the classical Ramsey technique approach.

  10. Assessment of the LH wave for demo in pulsed and steady state scenario

    NASA Astrophysics Data System (ADS)

    Cardinali, A.; Barbato, E.; Castaldo, C.; Ceccuzzi, S.; Cesario, R.; Marinucci, M.; Mirizzi, F.; Panaccione, L.; Ravera, G. L.; Santini, F.; Schettini, G.; Tuccillo, A. A.

    2014-02-01

    The Lower Hybrid Current Drive (LHCD) has been analysed in DEMO tokamak plasma in the "pulsed and steady state regime" considering two plasma scenarios characterized, respectively, by flat density profile and peaked density profiles. We have obtained LH deposition profiles in cases of neglecting the effect of spectral broadening produced by PI at the edge. By comparing the Power Deposition Profiles for both DEMO scenarios ("flat" and "peaked"), the SOL of DEMO does not play any role in the absorption of the LH wave. In all cases the deposition is localized inside the separatrix layer r/a≤1. By lowering the parallel wave-number peak of the power spectrum from 1.8 to 1.5, the accessibility condition in both case prevents the power from reaching the deposition layer apart from a small fraction which pertains to the higher n∥ of the power spectrum. The spectrum centred at 1.8 is suggested to be useful in DEMO. More realistically, as supported by available data of LHCD in a wide range of operating densities, the effect of parametric decay instability (PDI) can produce a spectral broadening which should be included in the simulations. Further studies would be necessary for assessing the temperature profiles in the SOL at reactor-graded conditions. This is because, if the SOL temperature is at least of the order of 50 to 100 eV, the effect of PDI broads the spectrum up to n∥≤10, and the deposition profile is slightly wider but not much shifted outwards.

  11. Assessment of the LH wave for demo in pulsed and steady state scenario

    SciTech Connect

    Cardinali, A.; Barbato, E.; Castaldo, C.; Cesario, R.; Marinucci, M.; Ravera, G. L.; Tuccillo, A. A.; Ceccuzzi, S.; Mirizzi, F.; Panaccione, L.; Santini, F.; Schettini, G.

    2014-02-12

    The Lower Hybrid Current Drive (LHCD) has been analysed in DEMO tokamak plasma in the 'pulsed and steady state regime' considering two plasma scenarios characterized, respectively, by flat density profile and peaked density profiles. We have obtained LH deposition profiles in cases of neglecting the effect of spectral broadening produced by PI at the edge. By comparing the Power Deposition Profiles for both DEMO scenarios ('flat' and 'peaked'), the SOL of DEMO does not play any role in the absorption of the LH wave. In all cases the deposition is localized inside the separatrix layer r/a≤1. By lowering the parallel wave-number peak of the power spectrum from 1.8 to 1.5, the accessibility condition in both case prevents the power from reaching the deposition layer apart from a small fraction which pertains to the higher n∥ of the power spectrum. The spectrum centred at 1.8 is suggested to be useful in DEMO. More realistically, as supported by available data of LHCD in a wide range of operating densities, the effect of parametric decay instability (PDI) can produce a spectral broadening which should be included in the simulations. Further studies would be necessary for assessing the temperature profiles in the SOL at reactor-graded conditions. This is because, if the SOL temperature is at least of the order of 50 to 100 eV, the effect of PDI broads the spectrum up to n∥≤10, and the deposition profile is slightly wider but not much shifted outwards.

  12. Harmonic generation with a dual frequency pulse.

    PubMed

    Keravnou, Christina P; Averkiou, Michalakis A

    2014-05-01

    Nonlinear imaging was implemented in commercial ultrasound systems over the last 15 years offering major advantages in many clinical applications. In this work, pulsing schemes coupled with a dual frequency pulse are presented. The pulsing schemes considered were pulse inversion, power modulation, and power modulated pulse inversion. The pulse contains a fundamental frequency f and a specified amount of its second harmonic 2f. The advantages and limitations of this method were evaluated with both acoustic measurements of harmonic generation and theoretical simulations based on the KZK equation. The use of two frequencies in a pulse results in the generation of the sum and difference frequency components in addition to the other harmonic components. While with single frequency pulses, only power modulation and power modulated pulse inversion contained odd harmonic components, with the dual frequency pulse, pulse inversion now also contains odd harmonic components.

  13. Temporal concentrations of cortisol and LH in virgin ewes acutely exposed to rams during the transition into the breeding season.

    PubMed

    McCosh, R B; Berry, E M; Wehrman, M E; Redden, R R; Hallford, D M; Berardinelli, J G

    2015-03-01

    The objectives of this study were to determine if exposing seasonally anovular ewes to rams would alter patterns of cortisol concentrations, and if these changes are associated with changes in characteristics of LH concentrations. Seasonally anestrous ewes were assigned to be exposed to rams (RE; n=11) or wethers (NE; n=12). Blood samples were collected at 15-min intervals beginning 120 min before introduction of males (time=0 min), and continued for 360 min after male exposure. Characteristics of cortisol and LH concentrations included: mean and baseline concentrations, pulse amplitude, duration, frequency, and time to first pulse. Mean and baseline cortisol concentrations, and cortisol pulse amplitude, frequency, and time to first pulse after male exposure did not differ between RE and NE ewes. Cortisol pulse duration was longer (P<0.05) in RE ewes than in NE ewes. Mean LH and LH pulse amplitude, duration, and time to first pulse after male exposure did not differ between RE and NE ewes. Baseline LH concentrations and LH pulse frequency were greater (P<0.05) in RE than in NE ewes. In RE ewes, but not NE ewes, LH pulse frequency tended to increase (P=0.06) as pulse frequency of cortisol decreased. In conclusion, exposing ewes to mature rams during the transition into the breeding season increased LH pulse frequency which hastened ovulatory activity. However, the results do not support the hypothesis that changes in cortisol concentrations plays a significant role in the 'ram effect'.

  14. Evidence That Dopamine Acts via Kisspeptin to Hold GnRH Pulse Frequency in Check in Anestrous Ewes

    PubMed Central

    Maltby, Matthew J.; Millar, Robert P.; Hileman, Stanley M.; Nestor, Casey C; Whited, Brant; Tseng, Ashlie S.; Coolen, Lique M.; Lehman, Michael N.

    2012-01-01

    Recent work has implicated stimulatory kisspeptin neurons in the arcuate nucleus (ARC) as important for seasonal changes in reproductive function in sheep, but earlier studies support a role for inhibitory A15 dopaminergic (DA) neurons in the suppression of GnRH (and LH) pulse frequency in the nonbreeding (anestrous) season. Because A15 neurons project to the ARC, we performed three experiments to test the hypothesis that A15 neurons act via ARC kisspeptin neurons to inhibit LH in anestrus: 1) we used dual immunocytochemistry to determine whether these ARC neurons contain D2 dopamine receptor (D2-R), the receptor responsible for inhibition of LH in anestrus; 2) we tested the ability of local administration of sulpiride, a D2-R antagonist, into the ARC to increase LH secretion in anestrus; and 3) we determined whether an antagonist to the kisspeptin receptor could block the increase in LH secretion induced by sulpiride in anestrus. In experiment 1, 40% of this ARC neuronal subpopulation contained D2-R in breeding season ewes, but this increased to approximately 80% in anestrus. In experiment 2, local microinjection of the two highest doses (10 and 50 nmol) of sulpiride into the ARC significantly increased LH pulse frequency to levels 3 times that seen with vehicle injections. Finally, intracerebroventricular infusion of a kisspeptin receptor antagonist completely blocked the increase in LH pulse frequency induced by systemic administration of sulpiride to anestrous ewes. These results support the hypothesis that DA acts to inhibit GnRH (and LH) secretion in anestrus by suppressing the activity of ARC kisspeptin neurons. PMID:23038740

  15. Frequency independent quenching of pulsed emission

    SciTech Connect

    Gajjar, Vishal; Joshi, Bhal Chandra; Kramer, Michael; Karuppusamy, Ramesh; Smits, Roy E-mail: bcj@ncra.tifr.res.in E-mail: ramesh@mpifr-bonn.mpg.de

    2014-12-10

    Simultaneous observations at four different frequencies, 313, 607, 1380, and 4850 MHz, for three pulsars, PSRs B0031–07, B0809+74, and B2319+60, are reported in this paper. Identified null and burst pulses are highly concurrent across more than a decade of frequency. A small fraction of non-concurrent pulses (≤3%) is observed, most of which occur at the transition instances. We report, with very high significance for the first time, the full broadband nature of the nulling phenomenon in these three pulsars. These results suggest that nulling invokes changes on the global magnetospheric scale.

  16. Time-frequency spectrograms of optical pulses

    SciTech Connect

    Beck, M.

    1995-11-01

    The authors present a discussion of several different types of joint time-frequency distributions of optical pulses. Particular attention is paid to the Wigner distribution W(t,{omega}), as it is the fundamental distribution from which all others can be derived. They elucidate the relationship between the Wigner distribution and other spectrograms of current-interest, such as that obtained from frequency-resolved optical gating (FROG).

  17. Decreased luteinizing hormone pulse frequency is associated with elevated 24-hour ghrelin after calorie restriction and exercise in premenopausal women

    PubMed Central

    Scheid, Jennifer L.; De Souza, Mary Jane; Hill, Brenna R.; Leidy, Heather J.

    2013-01-01

    Elevated ghrelin has been shown to be associated with reduced luteinizing hormone (LH) pulsatility in Rhesus monkeys, rats, men, and recently women. We previously reported that 24-h ghrelin concentrations are elevated in women following a 3-mo exercise and diet program leading to weight loss. We investigated whether the elevations in ghrelin following an ∼3-mo exercise and diet program leading to weight loss are associated with a decrease in LH pulsatility. The nonexercising control group (Control, n = 5) consumed a controlled diet that matched energy needs, whereas energy intake in the exercise group (Energy Deficit, n = 16) was reduced from baseline energy requirements and supervised exercise training occurred five times per a week. Significant decreases in body weight (−3.0 ± 0.6 kg), body fat (−2.9 ± 0.4 kg) and 24-h LH pulse frequency (−0.18 ± 0.08 pulses/h), and a significant increase in 24-h mean ghrelin were observed in only the Energy Deficit group. The pre-post change in LH pulse frequency was negatively correlated with the change in mean 24-h ghrelin (R = −0.485, P = 0.030) and the change in peak ghrelin at lunch (R = −0.518, P = 0.019). Interestingly, pre-post change in night LH pulse frequency was negatively correlated with the change in mean day ghrelin (R = −0.704, P = 0.001). Elevated total ghrelin concentrations are associated with the suppression of LH pulsatility in premenopausal women and may play a role in the suppression of reproductive function following weight loss. PMID:23115078

  18. Frequency modulation of semiconductor disk laser pulses

    SciTech Connect

    Zolotovskii, I O; Korobko, D A; Okhotnikov, O G

    2015-07-31

    A numerical model is constructed for a semiconductor disk laser mode-locked by a semiconductor saturable absorber mirror (SESAM), and the effect that the phase modulation caused by gain and absorption saturation in the semiconductor has on pulse generation is examined. The results demonstrate that, in a laser cavity with sufficient second-order dispersion, alternating-sign frequency modulation of pulses can be compensated for. We also examine a model for tuning the dispersion in the cavity of a disk laser using a Gires–Tournois interferometer with limited thirdorder dispersion. (control of radiation parameters)

  19. Optical frequency comb generation by pulsed pumping

    NASA Astrophysics Data System (ADS)

    Malinowski, Marcin; Rao, Ashutosh; Delfyett, Peter; Fathpour, Sasan

    2017-06-01

    A synchronously pumped Kerr cavity is proposed and studied for power-efficient frequency comb generation in optical microring resonators. The system is modeled using the Lugiato-Lefever equation. Analytical solutions are provided for an ideal case and extended by numerical methods to account for optical loss and higher orders of dispersion. It is shown that the average power requirement is reduced by the duty cycle of the pulse with respect to the conventional continuous-wave-pumped microrings, and it is significantly lower than the pulsed pumping of straight waveguides.

  20. High Frequency Self-pulsing Microplasmas

    NASA Astrophysics Data System (ADS)

    Lassalle, John; Pollard, William; Staack, David

    2014-10-01

    Pulsing behavior in high-pressure microplasmas was studied. Microplasmas are of interest because of potential application in plasma switches for robust electronics. These devices require fast switching. Self-pulsing microplasmas were generated in a variable-length spark gap at pressures between 0 and 220 psig in Air, Ar, N2, H2, and He for spark gap lengths from 15 to 1810 μm. Resulting breakdown voltages varied between 90 and 1500 V. Voltage measurements show pulse frequencies as high as 8.9 MHz in argon at 100 psig. These findings demonstrate the potential for fast switching of plasma switches that incorporate high-pressure microplasmas. Work was supported by the National Science Foundation, Grant #1057175, and the Department of Defense, ARO Grant #W911NF1210007.

  1. Frequency content of current pulses in slapper detonator bridges

    SciTech Connect

    Carpenter, K H

    2006-12-18

    DFT amplitudes are obtained for digital current pulse files. The frequency content of slapper detonator bridge current pulses is obtained. The frequencies are confined well within the passband of the CVR used to sample them.

  2. Radio frequency CD by LH waves in the reversed field experiment

    SciTech Connect

    Bilato, R.; Brambilla, M.

    1999-09-20

    We present a feasibility study for the active control of the poloidal current density profile in the RFX (reversed field pinch) experiment using radio frequency in the range of lower hybrid waves. The main goal of the rf current drive is to reduce the magnetic fluctuations and the magnetic stochasticity, so as to improve the energy confinement. The compelling constraints of accessibility and damping of the slow waves due to the present and extrapolated RFX plasma parameters are investigated; they have been used to fix the frequency ({approx_equal}1.3 GHz) and the best n{sub parallel} values ({approx_equal}8), and therefore the antenna size (Grill). A modified version of the FELICE code, which takes into account the strong shear of the magnetic field of the RFP plasmas, has been developed and used to estimate the antenna-plasma coupling: the reflected power for the proposed antenna is found to be less than 30% for a quite wide range of plasma parameters. In order to estimate the current drive profile and efficiency a one dimensional Fokker-Planck code has been used: an additional crucial contribution to the driven current is due to the enhancement of the plasma conductivity as consequence of the suprathermal electron population increase. Although the total estimated CD efficiency is promising, the rf-power required to drive the current necessary to produce a significant reduction of the magnetic fluctuations is found to be in the MW range.

  3. Micro pulsed radio-frequency electroporation chips.

    PubMed

    He, Huiqi; Chang, Donald C; Lee, Yi-Kuen

    2006-01-01

    Electroporation (EP) is one of the most important physical methods in biotechnology, which employs electrical pulses to transiently permeabilize cell membranes. In this study, a new micro pulsed radio-frequency electroporation cell (microPREP) chip was fabricated using a lift-off technique and SU-8 photolithography. The biological tests were carried out using three different plant protoplasts (cabbage, spinach and oil rape) on the micro EP chip and a pulsed RF electric field was applied to the microchip. The variations of fluorescent intensity and cell viability as functions of the electric pulse amplitude and duration time during the electroporation process were studied in detail at the single-cell level. Using such chip design and test method, one can easily optimize the efficiency and cell viability. Also, a large amount of statistical data can be quickly obtained. Finally, results of this parametric study were presented in the "phase diagram", from which the critical electric field for inducing single-cell electroporation under different conditions can be clearly determined.

  4. Secretory pattern of leptin and LH during lactational amenorrhoea in breastfeeding normal and polycystic ovarian syndrome women.

    PubMed

    Sir-Petermann, T; Recabarren, S E; Lobos, A; Maliqueo, M; Wildt, L

    2001-02-01

    Several studies have suggested that leptin modulates hypothalamic-pituitary-gonadal axis function. A synchronicity of LH and leptin pulses has been described in healthy women and in patients with polycystic ovarian syndrome (PCOS), suggesting that leptin may modulate the episodic secretion of LH. The aim of the present investigation was to assess the episodic fluctuations of circulating LH and leptin during lactational amenorrhoea in fully breastfeeding normal and PCOS women at 4 and 8 weeks postpartum, in order to establish LH-leptin interactions in the reactivation of the gonadal axis during this period. Six lactating PCOS patients and six normal lactating women of similar age and body mass index were studied. During a 12 h period on the 4th and 8th weeks postpartum, blood samples were collected at 10 min intervals for 12 h (22:00-10:00). Serum LH and leptin concentrations were measured in all samples. For pulse analysis, the cluster algorithm was used. To detect an interaction between LH and leptin pulses, an analysis of co-pulsatility was employed. LH concentrations tended to increase in both groups between the 4th and 8th weeks postpartum; however, serum leptin concentrations were not modified. Leptin pulse frequencies were similar at the 4th and 8th weeks postpartum, and did not differ between groups. Moreover, leptin pulse frequency was higher than LH pulse frequency in both groups, and in the two study periods. There was no synchronicity between LH and leptin pulses, and there were no increments in leptin concentration during the night. The fact that leptin concentrations were not modified and no synchronicity between LH and leptin pulses was observed suggests that, during lactational amenorrhoea, circulating leptin is probably not involved as a primary signal in promoting the reactivation of pulsatile LH secretion.

  5. Dual-pulse frequency compounded superharmonic imaging.

    PubMed

    van Neer, Paul L M J; Danilouchkine, Mikhail G; Matte, Guillaume M; van der Steen, Anton F W; de Jong, Nico

    2011-11-01

    Tissue second-harmonic imaging is currently the default mode in commercial diagnostic ultrasound systems. A new modality, superharmonic imaging (SHI), combines the third through fifth harmonics originating from nonlinear wave propagation through tissue. SHI could further improve the resolution and quality of echographic images. The superharmonics have gaps between the harmonics because the transducer has a limited bandwidth of about 70% to 80%. This causes ghost reflection artifacts in the superharmonic echo image. In this work, a new dual-pulse frequency compounding (DPFC) method to eliminate these artifacts is introduced. In the DPFC SHI method, each trace is constructed by summing two firings with slightly different center frequencies. The feasibility of the method was established using a single-element transducer. Its acoustic field was modeled in KZK simulations and compared with the corresponding measurements obtained with a hydrophone apparatus. Subsequently, the method was implemented on and optimized for a setup consisting of an interleaved phased-array transducer (44 elements at 1 MHz and 44 elements at 3.7 MHz, optimized for echocardiography) and a programmable ultrasound system. DPFC SHI effectively suppresses the ghost reflection artifacts associated with imaging using multiple harmonics. Moreover, compared with the single-pulse third harmonic, DPFC SHI improved the axial resolution by 3.1 and 1.6 times at the -6-dB and -20-dB levels, respectively. Hence, DPFC offers the possibility of generating harmonic images of a higher quality at a cost of a moderate frame rate reduction.

  6. Missing pulse detector for a variable frequency source

    DOEpatents

    Ingram, Charles B.; Lawhorn, John H.

    1979-01-01

    A missing pulse detector is provided which has the capability of monitoring a varying frequency pulse source to detect the loss of a single pulse or total loss of signal from the source. A frequency-to-current converter is used to program the output pulse width of a variable period retriggerable one-shot to maintain a pulse width slightly longer than one-half the present monitored pulse period. The retriggerable one-shot is triggered at twice the input pulse rate by employing a frequency doubler circuit connected between the one-shot input and the variable frequency source being monitored. The one-shot remains in the triggered or unstable state under normal conditions even though the source period is varying. A loss of an input pulse or single period of a fluctuating signal input will cause the one-shot to revert to its stable state, changing the output signal level to indicate a missing pulse or signal.

  7. Ultrasound vibrometry using orthogonal- frequency-based vibration pulses.

    PubMed

    Zheng, Yi; Yao, Aiping; Chen, Shigao; Urban, Matthew W; Lin, Haoming; Chen, Xin; Guo, Yanrong; Chen, Ke; Wang, Tianfu; Chen, Siping

    2013-11-01

    New vibration pulses are developed for shear wave generation in a tissue region with preferred spectral distributions for ultrasound vibrometry applications. The primary objective of this work is to increase the frequency range of detectable harmonics of the shear wave. The secondary objective is to reduce the required peak intensity of transmitted pulses that induce the vibrations and shear waves. Unlike the periodic binary vibration pulses, the new vibration pulses have multiple pulses in one fundamental period of the vibration. The pulses are generated from an orthogonal-frequency wave composed of several sinusoidal signals, the amplitudes of which increase with frequency to compensate for higher loss at higher frequency in tissues. The new method has been evaluated by studying the shear wave propagation in in vitro chicken and swine liver. The experimental results show that the new vibration pulses significantly increase tissue vibration with a reduced peak ultrasound intensity, compared with the binary vibration pulses.

  8. Ultrasound Vibrometry Using Orthogonal Frequency Based Vibration Pulses

    PubMed Central

    Zheng, Yi; Yao, Aiping; Chen, Shigao; Urban, Matthew W.; Lin, Haoming; Chen, Xin; Guo, Yanrong; Chen, Ke; Wang, Tianfu; Chen, Shiping

    2014-01-01

    New vibration pulses are developed for shear wave generation in a tissue region with preferred spectral distributions for ultrasound vibrometry applications. The primary objective of this work is to increase the frequency range of detectable harmonics of the shear wave. The secondary objective is to reduce the required peak intensity of transmitted pulses that induce the vibrations and shear waves. Unlike the periodic binary vibration pulses, the new vibration pulses have multiple pulses in one fundamental period of the vibration. The pulses are generated from an orthogonal-frequency wave composed of several sinusoidal signals of which the amplitudes increase with frequency to compensate for higher loss at higher frequency in tissues. The new method has been evaluated by studying the shear wave propagation in in vitro chicken and swine liver. The experimental results show that the new vibration pulses significantly increase tissue vibration with a reduced peak ultrasound intensity, compared with the binary vibration pulses. PMID:24158291

  9. Low Frequency Electromagnetic Pulse and Explosions

    SciTech Connect

    Sweeney, J J

    2011-02-01

    This paper reviews and summarizes prior work related to low frequency (< 100 Hz) EMP (ElectroMagnetic Pulse) observed from explosions. It focuses on how EMP signals might, or might not, be useful in monitoring underground nuclear tests, based on the limits of detection, and physical understanding of these signals. In summary: (1) Both chemical and nuclear explosions produce an EMP. (2) The amplitude of the EMP from underground explosions is at least two orders of magnitude lower than from above ground explosions and higher frequency components of the signal are rapidly attenuated due to ground conductivity. (3) In general, in the near field, that is distances (r) of less than 10s of kilometers from the source, the amplitude of the EMP decays approximately as 1/r{sup 3}, which practically limits EMP applications to very close (<{approx}1km) distances. (4) One computational model suggests that the EMP from a decoupled nuclear explosion may be enhanced over the fully coupled case. This has not been validated with laboratory or field data. (5) The magnitude of the EMP from an underground nuclear explosion is about two orders of magnitude larger than that from a chemical explosion, and has a larger component of higher frequencies. In principle these differences might be used to discriminate a nuclear from a chemical explosion using sensors at very close (<{approx}1 km) distances. (6) Arming and firing systems (e.g. detonators, exploding bridge wires) can also produce an EMP from any type of explosion. (7) To develop the understanding needed to apply low frequency EMP to nuclear explosion monitoring, it is recommended to carry out a series of controlled underground chemical explosions with a variety of sizes, emplacements (e.g. fully coupled and decoupled), and arming and firing systems.

  10. Generating Submillimeter-Wave Frequencies From Laser Pulses

    NASA Technical Reports Server (NTRS)

    Spencer, Michael G.; Maserjian, Joseph

    1994-01-01

    Semiconductor photoconductive switches generate electrical pulses containing submillimeter-wavelength carrier signals (frequency between 300 and 3,000 GHz) and harmonics thereof when illuminated with short-rise-time pulses from lasers. Device of this type used as local oscilator in heterodyne submillimeter-wave receiver. Electrical output of device coupled via transmission line, waveguide, or antenna to mixer circuitry of receiver. Phase delays between optically activated semiconductor switches determine output carrier frequencies. N electrical pulses generated by each laser pulse. Thus, fundamental output frequency is N times laser-pulse-repetition rate.

  11. Assessment of pulse rate variability by the method of pulse frequency demodulation

    PubMed Central

    Hayano, Junichiro; Barros, Allan Kardec; Kamiya, Atsunori; Ohte, Nobuyuki; Yasuma, Fumihiko

    2005-01-01

    Background Due to its easy applicability, pulse wave has been proposed as a surrogate of electrocardiogram (ECG) for the analysis of heart rate variability (HRV). However, its smoother waveform precludes accurate measurement of pulse-to-pulse interval by fiducial-point algorithms. Here we report a pulse frequency demodulation (PFDM) technique as a method for extracting instantaneous pulse rate function directly from pulse wave signal and its usefulness for assessing pulse rate variability (PRV). Methods Simulated pulse wave signals with known pulse interval functions and actual pulse wave signals obtained from 30 subjects with a trans-dermal pulse wave device were analyzed by PFDM. The results were compared with heart rate and HRV assessed from simultaneously recorded ECG. Results Analysis of simulated data revealed that the PFDM faithfully demodulates source interval function with preserving the frequency characteristics of the function, even when the intervals fluctuate rapidly over a wide range and when the signals include fluctuations in pulse height and baseline. Analysis of actual data revealed that individual means of low and high frequency components of PRV showed good agreement with those of HRV (intraclass correlation coefficient, 0.997 and 0.981, respectively). Conclusion The PFDM of pulse wave signal provides a reliable assessment of PRV. Given the popularity of pulse wave equipments, PFDM may open new ways to the studies of long-term assessment of cardiovascular variability and dynamics. PMID:16259639

  12. Toward a High-Frequency Pulsed-Detonation Actuator

    NASA Technical Reports Server (NTRS)

    Cutler, Andrew D.; Drummond, J. Philip

    2006-01-01

    This paper describes the continued development of an actuator, energized by pulsed detonations, that provides a pulsed jet suitable for flow control in high-speed applications. A high-speed valve, capable of delivering a pulsed stream of reactants a mixture of H2 and air at rates of up to 1500 pulses per second, has been constructed. The reactants burn in a resonant tube and the products exit the tube as a pulsed jet. High frequency pressure transducers have been used to monitor the pressure fluctuations in the device at various reactant injection frequencies, including both resonant and off-resonant conditions. Pulsed detonations have been demonstrated in the lambda/4 mode of an 8 inch long tube at approx. 600 Hz. The pulsed jet at the exit of the device has been observed using shadowgraph and an infrared camera.

  13. Toward a High-Frequency Pulsed-Detonation Actuator

    NASA Technical Reports Server (NTRS)

    Cutler, Andrew D.; Drummond, J. Philip

    2006-01-01

    This paper describes the continued development of an actuator, energized by pulsed detonations, that provides a pulsed jet suitable for flow control in high-speed applications. A high-speed valve, capable of delivering a pulsed stream of reactants a mixture of H2 and air at rates of up to 1500 pulses per second, has been constructed. The reactants burn in a resonant tube and the products exit the tube as a pulsed jet. High frequency pressure transducers have been used to monitor the pressure fluctuations in the device at various reactant injection frequencies, including both resonant and off-resonant conditions. Pulsed detonations have been demonstrated in the lambda/4 mode of an 8 inch long tube at approximately 600 Hz. The pulsed jet at the exit of the device has been observed using shadowgraph and an infrared camera.

  14. Neural pulse frequency modulation of an exponentially correlated Gaussian process

    NASA Technical Reports Server (NTRS)

    Hutchinson, C. E.; Chon, Y.-T.

    1976-01-01

    The effect of NPFM (Neural Pulse Frequency Modulation) on a stationary Gaussian input, namely an exponentially correlated Gaussian input, is investigated with special emphasis on the determination of the average number of pulses in unit time, known also as the average frequency of pulse occurrence. For some classes of stationary input processes where the formulation of the appropriate multidimensional Markov diffusion model of the input-plus-NPFM system is possible, the average impulse frequency may be obtained by a generalization of the approach adopted. The results are approximate and numerical, but are in close agreement with Monte Carlo computer simulation results.

  15. Giant Crab pulses at low frequency: statistics, scattering, polarization

    SciTech Connect

    Smirnova, T. V.

    2010-01-01

    We carried out observations of Crab giant pulses at frequency 112 MHz from 2005 till 2008 on the Large Phased Array of the Pushchino Radio Astronomy Observatory. The scattering of pulses observed in various series varies by a factor of 3: from 11 ms in November 2005 till 34 ms in September 2008. The cumulative probability distribution for the peak intensities of the giant pulses for each of these series shows that the distribution is stable and is a power law with a single slope (n = -2.3). This testifies to stability of the mechanism generating the giant pulses. The energy in the pulses is conserved; i.e., the increase in the pulse intensity is proportional to the decrease in the scattering. Refractive scintillations at low frequencies in measurements with large time separation lead to variations in the relative number of giant pulses exceeding a given amplitude, proportional to the ratio of the mean flux densities of the pulsar in the corresponding observational series. The maximum energy of the recorded giant pulses is 2.5x10{sup 7} Jy mus. Analysis of the giant pulses observed at other frequencies shows that the frequency dependence of the maximum energy of the giant pulses in the range of 23 MHz-9 GHz is a power-law with index -2.2+-0.2. We measured the rotation measure using GP which is RM (-47.5+-0.4) rad/m{sup 2}, and the degree of linear polarization for pulses with measured frequency modulation was 9% divide 17% for November 2005.

  16. High-frequency and brief-pulse stimulation pulses terminate cortical electrical stimulation-induced afterdischarges.

    PubMed

    Ren, Zhi-Wei; Li, Yong-Jie; Yu, Tao; Ni, Duan-Yu; Zhang, Guo-Jun; Du, Wei; Piao, Yuan-Yuan; Zhou, Xiao-Xia

    2017-06-01

    Brief-pulse stimulation at 50 Hz has been shown to terminate afterdischarges observed in epilepsy patients. However, the optimal pulse stimulation parameters for terminating cortical electrical stimulation-induced afterdischarges remain unclear. In the present study, we examined the effects of different brief-pulse stimulation frequencies (5, 50 and 100 Hz) on cortical electrical stimulation-induced afterdischarges in 10 patients with refractory epilepsy. Results demonstrated that brief-pulse stimulation could terminate cortical electrical stimulation-induced afterdischarges in refractory epilepsy patients. In conclusion, (1) a brief-pulse stimulation was more effective when the afterdischarge did not extend to the surrounding brain area. (2) A higher brief-pulse stimulation frequency (especially 100 Hz) was more likely to terminate an afterdischarge. (3) A low current intensity of brief-pulse stimulation was more likely to terminate an afterdischarge.

  17. The "Ram Effect": A "Non-Classical" Mechanism for Inducing LH Surges in Sheep.

    PubMed

    Fabre-Nys, Claude; Chanvallon, Audrey; Dupont, Joëlle; Lardic, Lionel; Lomet, Didier; Martinet, Stéphanie; Scaramuzzi, Rex J

    2016-01-01

    During spring sheep do not normally ovulate but exposure to a ram can induce ovulation. In some ewes an LH surge is induced immediately after exposure to a ram thus raising questions about the control of this precocious LH surge. Our first aim was to determine the plasma concentrations of oestradiol (E2) E2 in anoestrous ewes before and after the "ram effect" in ewes that had a "precocious" LH surge (starting within 6 hours), a "normal" surge (between 6 and 28h) and "late» surge (not detected by 56h). In another experiment we tested if a small increase in circulating E2 could induce an LH surge in anoestrus ewes. The concentration of E2 significantly was not different at the time of ram introduction among ewes with the three types of LH surge. "Precocious" LH surges were not preceded by a large increase in E2 unlike "normal" surges and small elevations of circulating E2 alone were unable to induce LH surges. These results show that the "precocious" LH surge was not the result of E2 positive feedback. Our second aim was to test if noradrenaline (NA) is involved in the LH response to the "ram effect". Using double labelling for Fos and tyrosine hydroxylase (TH) we showed that exposure of anoestrous ewes to a ram induced a higher density of cells positive for both in the A1 nucleus and the Locus Coeruleus complex compared to unstimulated controls. Finally, the administration by retrodialysis into the preoptic area, of NA increased the proportion of ewes with an LH response to ram odor whereas treatment with the α1 antagonist Prazosin decreased the LH pulse frequency and amplitude induced by a sexually active ram. Collectively these results suggest that in anoestrous ewes NA is involved in ram-induced LH secretion as observed in other induced ovulators.

  18. A preponderance of basic luteinizing hormone (LH) isoforms accompanies inappropriate hypersecretion of both basal and pulsatile LH in adolescents with polycystic ovarian syndrome.

    PubMed

    Ropelato, M G; Garcia-Rudaz, M C; Castro-Fernandez, C; Ulloa-Aguirre, A; Escobar, M E; Barontini, M; Veldhuis, J D

    1999-12-01

    We recently demonstrated that adolescent girls with polycystic ovarian syndrome (PCOS) exhibit augmented LH secretion due to an increase in immunofluorometric and deconvolution-estimated LH secretory burst mass and pulse frequency. Concurrently, we inferred either a prolongation of apparent (endogenous) LH half-life or elevated basal (nonpulsatile) LH release in PCOS. The in vivo half-life of LH molecules can be affected by the oligosaccharide side-chains, which also modify in vitro bioactivity and electrostatic change. Accordingly, as a surrogate estimator of altered endogenous LH half-life and/or biopotency in PCOS, we characterized the isoelectric properties of secreted LH isoforms and determined their in vitro biological activity in adolescent girls with PCOS compared with healthy age-matched eumenorrheic controls. To this end, 12-h (overnight) serum samples from PCOS patients (n = 12) and normal adolescents (n = 10) were pooled by subject. Bioactive LH concentrations were then quantitated in a rat Leydig cell in vitro bioassay, and immunological activity was determined by immunofluorometry. The distribution of LH isoforms was evaluated by preparative chromatofocusing (pH window, 10.5 to <4.0) of samples further combined to yield three independent serum pools for each of the patient and control groups. Fasting serum concentrations of 17-hydroxyprogesterone (17-OHP), androstenedione, testosterone, estrone, estradiol, and sex hormone-binding globulin were determined as possible endocrine correlates of LH isotypes. Mean serum concentrations of immunoreactive and bioactive LH in adolescents with PCOS were 3 and 2 times higher than values in controls: immunoreactive: PCOS, 7.8+/-0.9; controls: 2.6+/-0.3 IU/L (P < 0.001); and bioactive: PCOS, 52+/-10; controls, 25+/-4.1 IU/L (P = 0.002), respectively. Bioactive LH concentrations correlated positively with 17-OHP (P = 0.022), androstenedione (P = 0.012), and testosterone (P = 0.046) concentrations in PCOS

  19. Vibrational sum frequency generation spectroscopy using inverted visible pulses.

    PubMed

    Weeraman, Champika; Mitchell, Steven A; Lausten, Rune; Johnston, Linda J; Stolow, Albert

    2010-05-24

    We present a broadband vibrational sum frequency generation (BB-VSFG) scheme using a novel ps visible pulse shape. We generate the fs IR pulse via standard procedures and simultaneously generate an 'inverted' time-asymmetric narrowband ps visible pulse via second harmonic generation in the pump depletion regime using a very long nonlinear crystal which has high group velocity mismatch (LiNbO3). The 'inverted' ps pulse shape minimally samples the instantaneous nonresonant response but maximally samples the resonant response, maintaining high spectral resolution. We experimentally demonstrate this scheme, presenting SFG spectra of canonical organic monolayer systems in the C-H stretch region (2800-3000 cm(-1)).

  20. Long Pulse Enhanced Confinement Discharges in the HT-7 Superconducting Tokamak by IBW Heating and LH Wave Current Drive

    NASA Astrophysics Data System (ADS)

    Li, Jiangang

    2002-11-01

    Significant progress has been made on the HT-7 superconducting tokamak in the past year toward obtaining advanced operating modes in steady state. By combining IBW and LHCD, ELM-free limiter H-mode discharges with H_89 2, β _N*H_89 > 3 have been obtained that lasted for 53% τE . A well boronized wall prevented the further impurity accumulation and the large pumping kept the recycling at a very low level. The density kept almost constant with the feedback control. The non-inductive driven current fraction is about 60% and bootstrap fraction is about 18%. The central electron temperature is about 2.6 keV and density above 2 X 10^19 m-3. With reduced plasma parameters of central Te 1.5 keV and n_e0 2 X 10^19 m-3, H_89 1.45, βN 1.1, the improved confinement phase lasts for more than 100τE with the non-inductive driven current fraction 70%. Several technical improvements, especially suitable for teady-state operation, have been made to get these long pulse, enhanced confinement discharges. The new GBST1308 doped graphite coated with a 100 μ m functional gradient coating of SiC film was used as limiter material. The tiles can withstand 5 MW/m^2 heat loads for 30 seconds with water-cooling. Twenty-four pieces of a ferromagnetic material -- ferritic steel -- have been installed to reduce the ripple at the limiter radius from 4% to less than 1.6%. Two large cry-pumps were installed to control particle exhaust. New RF wall coating techniques suitable for superconducting operation, such as RF boronization, siliconization and long-life Li coating, have been developed and routinely used in the HT-7 tokamak. This contributes to the significant reduction of the impurity radiation and edge recycling. Edge turbulence measured by Langmuir probes has been suppressed either by IBW or by LHCD for a low recycling and boronized wall. The edge electric field shear has been modified by IBW and LHCD. Transport analysis of sawtooth heat pulse propagation shows very low electron heat

  1. Differential processing for frequency chirp measurement using optical pulse synthesizer

    NASA Astrophysics Data System (ADS)

    Kashiwagi, Ken; Seki, Satoshi; Tsuda, Hiroyuki; Takenouchi, Hirokazu; Kurokawa, Takashi

    2017-03-01

    In this study, we introduced an optical pulse synthesizer (OPS) to measure frequency chirps of optical pulses by differential processing. The OPS has a single-chip integrated structure of all elements for the differential filtering and enables stable measurement. Because the exact filter causes a large loss, we employed a phase-only filter, whose frequency response was only in phase. We measured chirp rates of pulses which were induced by propagating standard single mode fibers with different lengths. The retrieved chirp rates were comparable to calculated results. We simulated accuracy of the method and concluded that our experiment had phase control accuracy within 0.07π.

  2. Actions of estradiol on discrete attributes of the luteinizing hormone pulse signal in man. Studies in postmenopausal women treated with pure estradiol.

    PubMed Central

    Veldhuis, J D; Evans, W S; Rogol, A D; Thorner, M O; Stumpf, P

    1987-01-01

    We assessed the time-dependent impact of estradiol on properties of the luteinizing hormone (LH) pulse signal in 12 hypoestrogenemic postmenopausal volunteers studied basally and after 1, 5, 10, and 30 d of estradiol delivery via an intravaginal Silastic ring. Computerized analysis of the plasma LH time series revealed a significant decrease in LH pulse frequency within 24 h of estrogen treatment, followed by a secondary increase (days 5 and 10), and then a sustained decline (day 30) in LH pulsatility. Estradiol also significantly suppressed incremental and maximal (but not fractional) LH pulse amplitudes in a biphasic manner. In contrast, LH peak duration was invariant until day 30 of estradiol replacement. These observations indicate that the well recognized biphasic actions of estradiol on mean serum LH concentrations can be modeled in relation to specific and time-dependent alterations in LH pulse frequency and amplitude. PMID:3818948

  3. Generation of frequency-chirped optical pulses with felix

    SciTech Connect

    Knippels, G.M.H.; Meer, A.F.G. van der; Mols, R.F.X.A.M.

    1995-12-31

    Frequency-chirped optical pulses have been produced in the picosecond regime by varying the energy of the electron beam on a microsecond time scale. These pulses were then compressed close to their bandwidth limit by an external pulse compressor. The amount of chirp can be controlled by varying the sweep rate on the electron beam energy and by cavity desynchronisation. To examine the generated chirp we used the following diagnostics: a pulse compressor, a crossed beam autocorrelator, a multichannel electron spectrometer and multichannel optical spectrometer. The compressor is build entirely using reflective optics to permit broad band operation. The autocorrelator is currently operating from 6 {mu}m to 30 {mu}m with one single crystal. It has been used to measure pulses as short as 500 fs. All diagnostics are evacuated to prevent pulse shape distortion or pulse lengthening caused by absorption in ambient water vapour. Pulse length measurements and optical spectra will be presented for different electron beam sweep rates, showing the presence of a frequency chirp. Results on the compression of the optical pulses to their bandwidth limit are given for different electron sweep rates. More experimental results showing the dependence of the amount of chirp on cavity desynchronisation will be presented.

  4. High-frequency Pulse-tube Refrigerator for 4 K

    NASA Astrophysics Data System (ADS)

    Tanaeva, I. A.; Klaasse Bos, C. G.; de Waele, A. T. A. M.

    2006-04-01

    At present pulse-tube refrigerators (PTRs), used for the important temperature region of 4 K, are of the Gifford-McMahon (GM)-type. The main sources of losses in GM-type PTRs are the compressor and the rotary valve. The efficiency of the combination of the compressor and the rotary valve is only about 30%. In addition to that GM-type compressors are heavy and need periodic maintenance. The main goal of this research is to develop a Stirling-type 4-K pulse-tube refrigerator. This implies higher operating frequencies, compared to the usual 1-2 Hz. At higher frequencies a number of properties of a pulse-tube system, such as length-to-diameter ratios of the pulse tubes and the regenerator, volume and configuration of a regenerator material, phase-shift control method, etc., change significantly, and, therefore, require detailed study. The interactions between various parameters of the pulse tube and of the linear compressor are very complicated. Therefore, as a first part of this research, we study the pulse tube at high frequencies, independent of the compressor. We generate high-frequency pressure oscillations, using a GM-type compressor and a special type of rotary valve, which enables us to operate at frequencies up to 20 Hz. Results of this work are described in this contribution.

  5. Simultaneous multi-frequency single pulse observations of pulsars

    NASA Astrophysics Data System (ADS)

    Naidu, A.; Joshi, B. C.; Manoharan, P. K.; KrishnaKumar, M. A.

    2017-08-01

    Aims: We report on simultaneous multi-frequency single pulse observations of a sample of pulsars with previously reported, frequency dependent subpulse drift inferred from non-simultaneous and short observations. We aim to clarify if the frequency dependence is a result of multiple drift modes in these pulsars. Methods: We performed simultaneous observations at 326.5 MHz with the Ooty Radio Telescope and at 326, 610, and 1308 MHz with the Giant Meterwave Radio Telescope for a sample of 12 pulsars, where frequency dependent single pulse behaviour was reported. The single pulse sequences were analysed with three types of fluctuation analysis techniques, namely longitude-resolved fluctuation spectrum technique, two-dimensional fluctuation spectrum technique and sliding two-dimensional fluctuation spectrum technique. The first two techniques are sensitive to average fluctuation properties of the pulses, whereas the last technique is used for examining the temporal behaviour of the pulses. Results: We report subpulse drifting in PSR J0934-5249 for the first time. We also report pulse nulling measurements in PSRs J0934-5249, B1508+55, J1822-2256, B1845-19, and J1901-0906 for the first time. Our measurements of subpulse drifting and pulse nulling for the rest of the pulsars are consistent with previously reported values. Contrary to previous belief, we find no evidence for a frequency dependent drift pattern in PSR B2016+28 as reported in previous studies. In PSRs B1237+25, J1822-2256, J1901-0906, and B2045-16, our longer and more sensitive observations reveal multiple drift rates with distinct P3. We increase the sample of pulsars showing concurrent nulling across multiple frequencies by more than 100 percent, adding four more pulsars to this sample. Our results confirm and further strengthen the understanding that the subpulse drifting and pulse nulling are consistent in the broadband with previous studies and are closely tied to physics of polar gap.

  6. Effects of alcohol on pulsatile luteinizing hormone (LH) and follicle stimulating hormone (FSH) secretion in the adult male rat

    SciTech Connect

    Badger, T.M.; Abdallah, M.M.; Hayden, J.B. )

    1989-02-09

    To determine possible hypothalamic actions of alcohol on hormone secretion, the effects of acute intragastric alcohol on plasma LH and FSH pulsations were studied. One jugular and one intragastric cannula were surgically implanted into adult male Sprague Dawley rats. Eight days later, rats were bilaterally castrated at 1400 h and infused intragastrically with either saline or 3 g/kg ethanol between 0700 h 0800 h the next days. Blood samples (300 microliters) were collected every 5 min for 3 h (starting at 0800 h), centrifuged and the plasma was frozen for LH and FSH radioimmunoassay. The blood cells were resuspended in saline and returned to the animal immediately following the next sample collection. While the mean plasma LH or FSH concentration did not vary significantly between the alcohol-treated and saline-treated rats, the mean LH (but not FSH) pulse frequency was lower in ethanol-treated rats (3.3 {plus minus} 0.25 pulses/3 h) than saline-treated controls (7.2 {plus minus} 0.3 pulses/3 h). In addition, mean area under the OH pulses were significantly greater in ethanol-treated than saline controls. These data suggest that: (1) ethanol acts to reduce the frequency of LHRH release for the hypothalamus and increase the area under each LH pulse; and (2) LH and FSH secretion are differentially regulated.

  7. Sleep-associated augmentation and synchronization of luteinizing hormone pulses in adult men.

    PubMed

    Fehm, H L; Clausing, J; Kern, W; Pietrowsky, R; Born, J

    1991-09-01

    We reinvestigated the temporal relationship between sleep and LH secretion in healthy adult males by comparing LH secretion patterns during sleep with those during the 6 h of wakefulness preceding the sleep epoch. Sleep stages were determined by somnopolygraphy. In these subjects LH secretion was augmented during sleep as indicated by increased mean LH concentrations and increased pulse amplitudes; pulse frequency was not different. In addition, LH secretion appeared to be synchronized to the NonREM-REM sleep cycles: initiation of LH pulses occurred preferentially in the mid-portion of a NonREM-REM cycle during Non-REM sleep. Thus, REM sleep was almost uniformly associated with decreasing LH concentration. These findings demonstrate that patterns of LH secretion characteristic for early puberty are principally present also in adult males.

  8. Parametric Study of High Frequency Pulse Detonation Tubes

    NASA Technical Reports Server (NTRS)

    Cutler, Anderw D.

    2008-01-01

    This paper describes development of high frequency pulse detonation tubes similar to a small pulse detonation engine (PDE). A high-speed valve injects a charge of a mixture of fuel and air at rates of up to 1000 Hz into a constant area tube closed at one end. The reactants detonate in the tube and the products exit as a pulsed jet. High frequency pressure transducers are used to monitor the pressure fluctuations in the device and thrust is measured with a balance. The effects of injection frequency, fuel and air flow rates, tube length, and injection location are considered. Both H2 and C2H4 fuels are considered. Optimum (maximum specific thrust) fuel-air compositions and resonant frequencies are identified. Results are compared to PDE calculations. Design rules are postulated and applications to aerodynamic flow control and propulsion are discussed.

  9. Nyquist pulse generator by techniques of frequency synthetization

    NASA Astrophysics Data System (ADS)

    Guo, Cheng; Yang, Tianxin; Lu, Zhaoyu; Ge, Chunfeng; Wang, Zhaoying

    2017-02-01

    Nyquist pulses, which are defined as responses of Nyquist filter, can be used in time-division multiplexing transmission which can simultaneously achieve ultrahigh data rate and spectral efficiency (SE). Generally, the methods for Nyquist pulse generation are based on optical Nyquist filters, nonlinear effects in fiber and phase-locked frequency comb. In this paper, we focus on the third method of phase-locked frequency comb. However, this method has a problem which the large duty cycle of generated Nyquist pulses limits their applications. To address this issue, we proposed a new setup in which one optical intensity modulator and an electrical arbitrary function generator (AFG) are employed. The various duty cycles of ideal Nyquist pulses are generated using one optical intensity modulator so that the phase-locking between the different RF signals is no need any more. And the ideal Nyquist pulses in microwave domain are generated successfully. The duty cycles ranging from 21% to 11% are obtained by programming the number of frequency comb lines in the RF signal which is generated by the AFG. The method has a potential to generate ideal Nyquist pulses in radio frequency domain if a high bandwidth AFG is used to replace the low bandwidth AFG used in this paper.

  10. Frequency domain fluorometry with pulsed light-emitting diodes.

    PubMed

    Herman, Petr; Vecer, Jaroslav

    2008-01-01

    We present a simple way to extend the time resolution of a standard frequency domain (FD) fluorometer by use of pulsed light-emitting diodes (LEDs) as an excitation source. High temporal resolution of the multifrequency FD method requires the excitation light to be modulated up to the highest possible frequencies with high modulation depth. We used harmonic content of subnanosecond-pulsed LEDs for generation of modulated excitation light. By a replacement of the light source, the upper frequency limit increased to 500-600 MHz, which is almost triple the frequency limit of the standard FD fluorometer equipped with an ordinary photomultiplier tube and an electro-optical modulator. Besides the increased time resolution, this approach allowed for elimination of a light modulator with an associated synthesizer and radio frequency power amplifier that are normally required for FD measurements with continuous wave light sources. Performance of the instrument with pulsed LED excitation is demonstrated on several examples of ultraviolet-excited fluorescence decays. We show that pulsed LEDs can serve as an inexpensive alternative to pulsed laser sources for FD fluorescence spectroscopy.

  11. Frequency tracked gated pulse technique for ultrasonic frequency

    NASA Technical Reports Server (NTRS)

    Cantrell, Jr., John H. (Inventor); Heyman, Joseph S. (Inventor)

    1983-01-01

    A tracking generator 21 is slaved to a spectrum analyzer 23 to produce an input signal having a frequency that follows the frequency of the spectrum analyzer sweeping local oscillator 22. The input signal is gated to a transducer 26 by a transmitter gate 25 to produce ultrasonic waves in the sample 28. The resulting ultrasonic echoes are converted into electrical signals by the transducer and then gated into the spectrum analyzer by receiver gate 29. This arrangement produces spectra that are equivalent to shock-exciting the transducer with a true delta function shock-excitation.

  12. Cheap, Easy-To-Read Frequency Monitor For Pulsed Laser

    NASA Technical Reports Server (NTRS)

    Esporoles, Carlos

    1995-01-01

    Electronic circuit provides bar-graph display of difference between carrier frequency of pulsed laser transmitter and frequency of another laser serving as local oscillator in receiver. Display device linear array of light-emitting diodes (LED's), each representing 1-MHz portion of beat-frequency range from 20 to 40 MHz. Middle LED and neighbors green; LED's representing edges of passband yellow; LED's of frequencies outside passband red. Operator determines approximate relative frequency of transmitter at a glance by observing color and position of illuminated LED.

  13. Design and characterization of very high frequency pulse tube prototypes

    NASA Astrophysics Data System (ADS)

    Lopes, Diogo; Duval, Jean-Marc; Charles, Ivan; Butterworth, James; Trollier, Thierry; Tanchon, Julien; Ravex, Alain; Daniel, Christophe

    2012-06-01

    Weight and size are important features of a cryocooler when it comes to space applications. Given their reliability and low level of exported vibrations (due to the absence of moving cold parts), pulse tubes are good candidates for spatial purposes and their miniaturization has been the focus of many studies. We report on the design and performance of a small-scale very high frequency pulse tube prototype, modeled after two previous prototypes which were optimized with a numerical code.

  14. Modeling the Male Reproductive Endocrine Axis: Potential Role for a Delay Mechanism in the Inhibitory Action of Gonadal Steroids on GnRH Pulse Frequency.

    PubMed

    Ferasyi, Teuku R; Barrett, P Hugh R; Blache, Dominique; Martin, Graeme B

    2016-05-01

    We developed a compartmental model so we could test mechanistic concepts in the control of the male reproductive endocrine axis. Using SAAM II computer software and a bank of experimental data from male sheep, we began by modeling GnRH-LH feed-forward and LH-T feedback. A key assumption was that the primary control signal comes from a hypothetical neural network (the PULSAR) that emits a digital (pulsatile) signal of variable frequency that drives GnRH secretion in square wave-like pulses. This model produced endocrine profiles that matched experimental observations for the testis-intact animal and for changes in GnRH pulse frequency after castration and T replacement. In the second stage of the model development, we introduced a delay in the negative feedback caused by the aromatization of T to estradiol at the brain level, a concept supported by empirical observations. The simulations showed how changes in the process of aromatization could affect the response of the pulsatile signal to inhibition by steroid feedback. The sensitivity of the PULSAR to estradiol was a critical factor, but the most striking observation was the effect of time delays. With longer delays, there was a reduction in the rate of aromatization and therefore a decrease in local estradiol concentrations, and the outcome was multiple-pulse events in the secretion of GnRH/LH, reflecting experimental observations. In conclusion, our model successfully emulates the GnRH-LH-T-GnRH loop, accommodates a pivotal role for central aromatization in negative feedback, and suggests that time delays in negative feedback are an important aspect of the control of GnRH pulse frequency.

  15. Efficient Generation of Visible Femtosecond Pulses by Frequency Doubling

    NASA Astrophysics Data System (ADS)

    Wang, Guo (Gary) Yao

    In principle, second harmonic generation (SHG) can convert near-infrared femtosecond mode-locked pulses into visible and UV regions. However, the finite phase matching bandwidth makes it difficult to simultaneously phase match the entire pulse spectrum. Effects such as peak power saturation and pulse broadening arise as the length of a frequency-doubling crystal increases. To avoid these problems, very thin crystals have to be used, which results in low conversion efficiency unless the laser intensity is very high. Two new approaches based on quasi-phase match and traditional Cerenkov SHG are proposed in this thesis. In the former scheme, proper design provides the requisite delay of the fundamental pulses, resulting in simultaneous phase and group velocity matches. The latter scheme makes use of the auto-phase matching property of Cerenkov SHG to phase match the whole pulse spectrum. The stretched output pulses are compressed by a dispersion element, such as a prism or a grating. Pulse width preservation and high efficiency are thus expected from low pump power. Experiments to conform the latter proposal were conducted. Proton-exchanged MgO doped LiNbO_3 Cerenkov waveguides were used to double the frequency of a femtosecond Ti:sapphire laser. 25 mW blue harmonic pulses were generated from only 50 mW input. A diffraction grating compressed the stretched 2 psec pulses back to 300 fsec. The device is easy to make and to use. The concept presented can be extended to femtosecond pulses in any three-photon process in any waveguide material and any modelocked source.

  16. Velocity measurement using frequency domain interferometer and chirped pulse laser

    NASA Astrophysics Data System (ADS)

    Ishii, K.; Nishimura, Y.; Mori, Y.; Hanayama, R.; Kitagawa, Y.; Sekine, T.; Sato, N.; Kurita, T.; Kawashima, T.; Sunahara, A.; Sentoku, Y.; Miura, E.; Iwamoto, A.; Sakagami, H.

    2017-02-01

    An ultra-intense short pulse laser induces a shock wave in material. The pressure of shock compression is stronger than a few tens GPa. To characterize shock waves, time-resolved velocity measurement in nano- or pico-second time scale is needed. Frequency domain interferometer and chirped pulse laser provide single-shot time-resolved measurement. We have developed a laser-driven shock compression system and frequency domain interferometer with CPA laser. In this paper, we show the principle of velocity measurement using a frequency domain interferometer and a chirped pulse laser. Next, we numerically calculated spectral interferograms and show the time-resolved velocity measurement can be done from the phase analysis of spectral interferograms. Moreover we conduct the laser driven shock generation and shock velocity measurement. From the spectral fringes, we analyze the velocities of the sample and shockwaves.

  17. Evolution of the frequency chirp of Gaussian pulses and beams when passing through a pulse compressor.

    PubMed

    Li, Derong; Lv, Xiaohua; Bowlan, Pamela; Du, Rui; Zeng, Shaoqun; Luo, Qingming

    2009-09-14

    The evolution of the frequency chirp of a laser pulse inside a classical pulse compressor is very different for plane waves and Gaussian beams, although after propagating through the last (4th) dispersive element, the two models give the same results. In this paper, we have analyzed the evolution of the frequency chirp of Gaussian pulses and beams using a method which directly obtains the spectral phase acquired by the compressor. We found the spatiotemporal couplings in the phase to be the fundamental reason for the difference in the frequency chirp acquired by a Gaussian beam and a plane wave. When the Gaussian beam propagates, an additional frequency chirp will be introduced if any spatiotemporal couplings (i.e. angular dispersion, spatial chirp or pulse front tilt) are present. However, if there are no couplings present, the chirp of the Gaussian beam is the same as that of a plane wave. When the Gaussian beam is well collimated, the introduced frequency chirp predicted by the plane wave and Gaussian beam models are in closer agreement. This work improves our understanding of pulse compressors and should be helpful for optimizing dispersion compensation schemes in many applications of femtosecond laser pulses.

  18. FREQUENCY DEPENDENCE OF PULSE WIDTH FOR 150 RADIO NORMAL PULSARS

    SciTech Connect

    Chen, J. L.; Wang, H. G.

    2014-11-01

    The frequency dependence of the pulse width is studied for 150 normal pulsars, mostly selected from the European Pulsar Network, for which the 10% multifrequency pulse widths can be well fit with the Thorsett relationship W {sub 10} = Aν{sup μ} + W {sub 10,} {sub min}. The relative fraction of pulse width change between 0.4 GHz and 4.85 GHz, η = (W {sub 4.85} – W {sub 0.4})/W {sub 0.4}, is calculated in terms of the best-fit relationship for each pulsar. It is found that 81 pulsars (54%) have η < –10% (group A), showing considerable profile narrowing at high frequencies, 40 pulsars (27%) have –10% ≤η ≤ 10% (group B), meaning a marginal change in pulse width, and 29 pulsars (19%) have η > 10% (group C), showing a remarkable profile broadening at high frequencies. The fractions of the group-A and group-C pulsars suggest that the profile narrowing phenomenon at high frequencies is more common than the profile broadening phenomenon, but a large fraction of the group-B and group-C pulsars (a total of 46%) is also revealed. The group-C pulsars, together with a portion of group-B pulsars with slight pulse broadening, can hardly be explained using the conventional radius-to-frequency mapping, which only applies to the profile narrowing phenomenon. Based on a recent version of the fan beam model, a type of broadband emission model, we propose that the diverse frequency dependence of pulse width is a consequence of different types of distribution of emission spectra across the emission region. The geometrical effect predicting a link between the emission beam shrinkage and spectrum steepening is tested but disfavored.

  19. Frequency spectra of nonlinear elastic pulse-mode waves

    SciTech Connect

    Kadish, A.; TenCate, J.A.; Johnson, P.A.

    1996-09-01

    The frequency spectrum of simple waves is used to derive a closed form analytical representation for the frequency spectrum of damped nonlinear pulses in elastic materials. The damping modification of simple wave theory provides an efficient numerical method for calculating propagating wave forms. The spectral representation, which is neither pulse length nor amplitude limited, is used to obtain estimates for parameters of the nonlinear state relation for a sandstone sample from published experimental data, and the results are compared with those of other theories. The method should have broad application to many solids.

  20. A very wide frequency band pulsed/IF radar system

    NASA Technical Reports Server (NTRS)

    Jones, D. N.; Burnside, W. D.

    1988-01-01

    A pulsed/IF radar for compact range radar cross section measurements has been developed which converts RF returns to a fixed IF, so that amplification and grating may be performed at one frequency. This permits the use of components which have optimal performance at this frequency which results in a corresponding improvement in performance. Sensitivity and dynamic range are calculated for this system and compared with our old radar, and the effect of pulse width on clutter level is also studied. Sensitivity and accuracy tests are included to verify the performance of the radar.

  1. LH (Luteinizing Hormone) Test

    MedlinePlus

    ... for luteinizing hormone (LH), a hormone associated with reproduction and the stimulation of the release of an ... LH and FSH with the development of secondary sexual characteristics at an unusually young age are an ...

  2. Why high-frequency pulse tubes can be tipped

    SciTech Connect

    Swift, Gregory W092710; Backhaus, Scott N

    2010-01-01

    The typical low-frequency pulse-tube refrigerator loses significant cooling power when it is tipped with the pulse tube's cold end above its hot end, because natural convection in the pulse tube loads the cold heat exchanger. Yet most high-frequency pulse-tube refrigerators work well in any orientation with respect to gravity. In such a refrigerator, natural convection is suppressed by sufficiently fast velocity oscil1ations, via a nonlinear hydrodynamic effect that tends to align the density gradients in the pulse tube parallel to the oscillation direction. Since gravity's tendency to cause convection is only linear in the pulse tube's end-to-end temperature difference while the oscillation's tendency to align density gradients with oscillating velocity is nonlinear, it is easiest to suppress convection when the end-to-end temperature difference is largest. Simple experiments demonstrate this temperature dependence, the strong dependence on the oscillating velocity, and little dependence on the magnitude or phase of the oscillating pressure. In some circumstances in this apparatus, the suppression of convection is a hysteretic function of oscillating velocity. In some other circumstances, a time-dependent convective state seems more difficult to suppress.

  3. Constant-Frequency Pulsed Phase-Locked-Loop Measuring Device

    NASA Technical Reports Server (NTRS)

    Yost, William T.; Cantrell, John H.; Kushnick, Peter W.

    1992-01-01

    Constant-frequency pulsed phase-locked-loop measuring device is sensitive to small changes in phase velocity and easily automated. Based on use of fixed-frequency oscillator in measuring small changes in ultrasonic phase velocity when sample exposed to such changes in environment as changes in pressure and temperature. Automatically balances electrical phase shifts against acoustical phase shifts to obtain accurate measurements of acoustical phase shifts.

  4. Constant-Frequency Pulsed Phase-Locked-Loop Measuring Device

    NASA Technical Reports Server (NTRS)

    Yost, William T.; Cantrell, John H.; Kushnick, Peter W.

    1992-01-01

    Constant-frequency pulsed phase-locked-loop measuring device is sensitive to small changes in phase velocity and easily automated. Based on use of fixed-frequency oscillator in measuring small changes in ultrasonic phase velocity when sample exposed to such changes in environment as changes in pressure and temperature. Automatically balances electrical phase shifts against acoustical phase shifts to obtain accurate measurements of acoustical phase shifts.

  5. Root responses to nitrogen pulse frequency under different nitrogen amounts

    NASA Astrophysics Data System (ADS)

    Yuan, Qing-Ye; Wang, Pu; Liu, Lu; Dong, Bi-Cheng; Yu, Fei-Hai

    2017-04-01

    Responses of morphology and biomass allocation of roots to frequency of nitrogen (N) pulse potentially influence the fitness of plants, but such responses may be determined by root size. We grew 12 plant species of three functional groups (grasses, forbs, and legumes) under two N pulse frequencies (high vs. low supply frequency) and two N amounts (high vs. low supply amount). Compared to low-amount N supply, high-amount N supply stimulated biomass accumulation and root growth by either increasing the thickness and length of roots or decreasing the root mass fraction. Compared to low-frequency N supply, high-frequency N supply improved biomass accumulation and root growth in forbs or grasses, but not in legumes. Furthermore, the magnitude of the response to N frequency was significantly negatively correlated with root size at the species scale, but this was only true when the N amount was high. We conclude that root responses to N frequency are related to plant functional types, and non-legume species is more sensitive to N frequency than legume species. Our results also suggest that root size is a determinant of root responses to N frequency when N supply amount is high.

  6. Nonselective excitation of pulsed ELDOR using multi-frequency microwaves

    NASA Astrophysics Data System (ADS)

    Asada, Yuki; Mutoh, Risa; Ishiura, Masahiro; Mino, Hiroyuki

    2011-12-01

    The use of a polychromatic microwave pulse to expand the pumping bandwidth in pulsed electron-electron double resonance (PELDOR) was investigated. The pumping pulse was applied in resonance with the broad (˜100 mT) electron paramagnetic resonance (EPR) signal of the manganese cluster of photosystem II in the S 2 state. The observation pulses were in resonance with the narrow EPR signal of the tyrosine radical, YDrad . It was found that in the case of the polychromatic pumping pulse containing five harmonics with the microwave frequencies between 8.5 and 10.5 GHz the PELDOR effect corresponding to the dipole interaction between the Mn cluster and YDrad was about 2.9 times larger than that achieved with a monochromatic pulse. In addition to the dipolar modulation, the nuclear modulation effects were observed. The effects could be suppressed by averaging the PELDOR trace over the time interval between the observation microwave pulses. The polychromatic excitation technique described will be useful for improving the PELDOR sensitivity in the measurements of long distances in biological samples, where the pair consists of a radical with a narrow EPR spectrum and slow phase relaxation, and a metal center that has a broad EPR spectrum and a short phase relaxation time.

  7. Nonselective excitation of pulsed ELDOR using multi-frequency microwaves.

    PubMed

    Asada, Yuki; Mutoh, Risa; Ishiura, Masahiro; Mino, Hiroyuki

    2011-12-01

    The use of a polychromatic microwave pulse to expand the pumping bandwidth in pulsed electron-electron double resonance (PELDOR) was investigated. The pumping pulse was applied in resonance with the broad (∼100 mT) electron paramagnetic resonance (EPR) signal of the manganese cluster of photosystem II in the S2 state. The observation pulses were in resonance with the narrow EPR signal of the tyrosine radical, YD·. It was found that in the case of the polychromatic pumping pulse containing five harmonics with the microwave frequencies between 8.5 and 10.5 GHz the PELDOR effect corresponding to the dipole interaction between the Mn cluster and YD· was about 2.9 times larger than that achieved with a monochromatic pulse. In addition to the dipolar modulation, the nuclear modulation effects were observed. The effects could be suppressed by averaging the PELDOR trace over the time interval between the observation microwave pulses. The polychromatic excitation technique described will be useful for improving the PELDOR sensitivity in the measurements of long distances in biological samples, where the pair consists of a radical with a narrow EPR spectrum and slow phase relaxation, and a metal center that has a broad EPR spectrum and a short phase relaxation time. Copyright © 2011 Elsevier Inc. All rights reserved.

  8. Frequency-Domain Methods for Characterization of Pulsed Power Diagnostics

    SciTech Connect

    White, A D; Anderson, R A; Ferriera, T J; Goerz, D A

    2009-07-27

    This paper discusses methods of frequency-domain characterization of pulsed power sensors using vector network analyzer and spectrum analyzer techniques that offer significant simplification over time-domain methods, while mitigating or minimizing the effect of the difficulties present in time domain characterization. These methods are applicable to characterization of a wide variety of sensors.

  9. Micromotion feature extraction of radar target using tracking pulses with adaptive pulse repetition frequency adjustment

    NASA Astrophysics Data System (ADS)

    Chen, Yijun; Zhang, Qun; Ma, Changzheng; Luo, Ying; Yeo, Tat Soon

    2014-01-01

    In multifunction phased array radar systems, different activities (e.g., tracking, searching, imaging, feature extraction, recognition, etc.) would need to be performed simultaneously. To relieve the conflict of the radar resource distribution, a micromotion feature extraction method using tracking pulses with adaptive pulse repetition frequencies (PRFs) is proposed in this paper. In this method, the idea of a varying PRF is utilized to solve the frequency-domain aliasing problem of the micro-Doppler signal. With appropriate atom set construction, the micromotion feature can be extracted and the image of the target can be obtained based on the Orthogonal Matching Pursuit algorithm. In our algorithm, the micromotion feature of a radar target is extracted from the tracking pulses and the quality of the constructed image is fed back into the radar system to adaptively adjust the PRF of the tracking pulses. Finally, simulation results illustrate the effectiveness of the proposed method.

  10. Driving frequency fluctuations in pulsed capacitively coupled plasmas

    NASA Astrophysics Data System (ADS)

    Poulose, John; Goeckner, Matthew; Shannon, Steven; Coumou, David; Overzet, Lawrence

    2017-09-01

    We report time resolved measurements of the RF current, voltage and complex impedance for pulsed plasmas through electropositive (Ar) and electronegative (CF4, O2) gases and gas mixtures. In addition, we report measurements of the effective frequency versus time at various locations within the RF circuitry. The frequency is found to fluctuate away from that sourced by the RF generator when the plasma re-ignites. Plasma re-ignition induces abrupt impedance changes due to the re-formation of the plasma sheath and bulk. These fast changes in the plasma impedance cause the measured changes in the voltage and current frequencies. As a result, the frequency of the RF power at the plasma electrodes was found to be as much as 250 kHz different from that being sourced by the RF generator for short periods of time. These frequency fluctuations are of particular interest to the application of frequency tuned matching networks.

  11. Above threshold dissociation in HD+ using frequency chirped laser pulses

    NASA Astrophysics Data System (ADS)

    Yuan, Kai-Jun; Liu, Zheng-Tang; Cong, Shu-Lin

    2011-06-01

    We have theoretically studied the dynamics of above threshold dissociation (ATD) in molecular ions HD+ using frequency chirped femtosecond laser pulses from numerical solutions of the time-dependent Schrödinger equation by using the three-dimensional time-dependent quantum wave packet method. Energy-dependent distributions of ATD fragments are analyzed by an asymptotic-flow expression in momentum space. Linearly positive and negative frequency chirped laser pulses are adopted. It is found that varying frequency chirped parameters can change branching ratios of the 1sσ g and 2pσ u dissociations channels. The concept of a light-induced potential is used to interpret the ATD process. The angular resolved energy distributions of the photofragments are also illustrated.

  12. Pulsed radio frequency energy (PRFE) use in human medical applications.

    PubMed

    Guo, Lifei; Kubat, Nicole J; Isenberg, Richard A

    2011-03-01

    A number of electromagnetic field-based technologies are available for therapeutic medical applications. These therapies can be broken down into different categories based on technical parameters employed and type of clinical application. Pulsed radio frequency energy (PRFE) therapy is a non invasive, electromagnetic field-based therapeutic that is based on delivery of pulsed, shortwave radio frequency energy in the 13-27.12 MHz carrier frequency range, and designed for local application to a target tissue without the intended generation of deep heat. It has been studied for use in a number of clinical applications, including as a palliative treatment for both postoperative and non postoperative pain and edema, as well as in wound healing applications. This review provides an introduction to the therapy, a summary of clinical efficacy studies using the therapy in specific applications, and an overview of treatment-related safety.

  13. Self-integrating inductive loop for measuring high frequency pulses

    NASA Astrophysics Data System (ADS)

    Rojas-Moreno, Mónica V.; Robles, Guillermo; Martínez-Tarifa, Juan M.; Sanz-Feito, Javier

    2011-08-01

    High frequency pulses can be measured by means of inductive sensors. The main advantage of these sensors consists of non-contact measurements that isolate and protect measuring equipment. The objective of this paper is to present the implementation of an inductive sensor for measuring rapidly varying currents. It consists of a rectangular loop with a resistor at its terminals. The inductive loop gives the derivative of the current according to Faraday's law and the resistor connected to the loop modifies the sensor's frequency response to obtain an output proportional to the current pulse. The self-integrating inductive sensor was validated with two sensors, a non-inductive resistor and a commercial high frequency current transformer. The results were compared to determine the advantages and drawbacks of the probe as an adequate inductive transducer.

  14. Vacuum electron acceleration by using two variable frequency laser pulses

    SciTech Connect

    Saberi, H.; Maraghechi, B.

    2013-12-15

    A method is proposed for producing a relativistic electron bunch in vacuum via direct acceleration by using two frequency-chirped laser pulses. We consider the linearly polarized frequency-chiped Hermit-Gaussian 0, 0 mode lasers with linear chirp in which the local frequency varies linearly in time and space. Electron motion is investigated through a numerical simulation using a three-dimensional particle trajectory code in which the relativistic Newton's equations of motion with corresponding Lorentz force are solved. Two oblique laser pulses with proper chirp parameters and propagation angles are used for the electron acceleration along the z-axis. In this way, an electron initially at rest located at the origin could achieve high energy, γ=319 with the scattering angle of 1.02{sup ∘} with respect to the z-axis. Moreover, the acceleration of an electron in different initial positions on each coordinate axis is investigated. It was found that this mechanism has the capability of producing high energy electron microbunches with low scattering angles. The energy gain of an electron initially located at some regions on each axis could be greatly enhanced compared to the single pulse acceleration. Furthermore, the scattering angle will be lowered compared to the acceleration by using laser pulses propagating along the z-axis.

  15. The “Ram Effect”: A “Non-Classical” Mechanism for Inducing LH Surges in Sheep

    PubMed Central

    Fabre-Nys, Claude; Chanvallon, Audrey; Dupont, Joëlle; Lardic, Lionel; Lomet, Didier; Martinet, Stéphanie; Scaramuzzi, Rex J.

    2016-01-01

    During spring sheep do not normally ovulate but exposure to a ram can induce ovulation. In some ewes an LH surge is induced immediately after exposure to a ram thus raising questions about the control of this precocious LH surge. Our first aim was to determine the plasma concentrations of oestradiol (E2) E2 in anoestrous ewes before and after the “ram effect” in ewes that had a “precocious” LH surge (starting within 6 hours), a “normal” surge (between 6 and 28h) and “late» surge (not detected by 56h). In another experiment we tested if a small increase in circulating E2 could induce an LH surge in anoestrus ewes. The concentration of E2 significantly was not different at the time of ram introduction among ewes with the three types of LH surge. “Precocious” LH surges were not preceded by a large increase in E2 unlike “normal” surges and small elevations of circulating E2 alone were unable to induce LH surges. These results show that the “precocious” LH surge was not the result of E2 positive feedback. Our second aim was to test if noradrenaline (NA) is involved in the LH response to the “ram effect”. Using double labelling for Fos and tyrosine hydroxylase (TH) we showed that exposure of anoestrous ewes to a ram induced a higher density of cells positive for both in the A1 nucleus and the Locus Coeruleus complex compared to unstimulated controls. Finally, the administration by retrodialysis into the preoptic area, of NA increased the proportion of ewes with an LH response to ram odor whereas treatment with the α1 antagonist Prazosin decreased the LH pulse frequency and amplitude induced by a sexually active ram. Collectively these results suggest that in anoestrous ewes NA is involved in ram-induced LH secretion as observed in other induced ovulators. PMID:27384667

  16. Low temperature high frequency coaxial pulse tube for space application

    SciTech Connect

    Charrier, Aurelia; Charles, Ivan; Rousset, Bernard; Duval, Jean-Marc

    2014-01-29

    The 4K stage is a critical step for space missions. The Hershel mission is using a helium bath, which is consumed day by day (after depletion, the space mission is over) while the Plank mission is equipped with one He4 Joule-Thomson cooler. Cryogenic chain without helium bath is a challenge for space missions and 4.2K Pulse-Tube working at high frequency (around 30Hz) is one option to take it up. A low temperature Pulse-Tube would be suitable for the ESA space mission EChO (Exoplanet Characterisation Observatory, expected launch in 2022), which requires around 30mW cooling power at 6K; and for the ESA space mission ATHENA (Advanced Telescope for High ENergy Astrophysics), to pre-cool the sub-kelvin cooler (few hundreds of mW at 15K). The test bench described in this paper combines a Gifford-McMahon with a coaxial Pulse-Tube. A thermal link is joining the intercept of the Pulse-Tube and the second stage of the Gifford-McMahon. This intercept is a separator between the hot and the cold regenerators of the Pulse-Tube. The work has been focused on the cold part of this cold finger. Coupled with an active phase shifter, this Pulse-Tube has been tested and optimized and temperatures as low as 6K have been obtained at 30Hz with an intercept temperature at 20K.

  17. Low temperature high frequency coaxial pulse tube for space application

    NASA Astrophysics Data System (ADS)

    Charrier, Aurelia; Charles, Ivan; Rousset, Bernard; Duval, Jean-Marc; Daniel, Christophe

    2014-01-01

    The 4K stage is a critical step for space missions. The Hershel mission is using a helium bath, which is consumed day by day (after depletion, the space mission is over) while the Plank mission is equipped with one He4 Joule-Thomson cooler. Cryogenic chain without helium bath is a challenge for space missions and 4.2K Pulse-Tube working at high frequency (around 30Hz) is one option to take it up. A low temperature Pulse-Tube would be suitable for the ESA space mission EChO (Exoplanet Characterisation Observatory, expected launch in 2022), which requires around 30mW cooling power at 6K; and for the ESA space mission ATHENA (Advanced Telescope for High ENergy Astrophysics), to pre-cool the sub-kelvin cooler (few hundreds of mW at 15K). The test bench described in this paper combines a Gifford-McMahon with a coaxial Pulse-Tube. A thermal link is joining the intercept of the Pulse-Tube and the second stage of the Gifford-McMahon. This intercept is a separator between the hot and the cold regenerators of the Pulse-Tube. The work has been focused on the cold part of this cold finger. Coupled with an active phase shifter, this Pulse-Tube has been tested and optimized and temperatures as low as 6K have been obtained at 30Hz with an intercept temperature at 20K.

  18. Wideband frequency-swept excitation in pulsed EPR spectroscopy

    NASA Astrophysics Data System (ADS)

    Doll, Andrin; Jeschke, Gunnar

    2017-07-01

    Excitation of electron spins with monochromatic rectangular pulses is limited to bandwidths that are smaller than the spectral widths of most organic radicals and much smaller than the spectral widths of transition and rare earth metal ions. With frequency-swept pulses, bandwidths of up to 800 MHz have previously been attained for excitation and detection of spin packets at frequencies of about 9.6 GHz and bandwidths of up to 2.5 GHz in a polarization transfer experiment at frequencies of about 34 GHz. The remaining limitations, mainly due to resonator bandwidth and due to pulse length restrictions are discussed. Flip angles for state-space rotations on passage of a transition can generally be computed from the critical adiabaticity by the Landau-Zener-Stückelberg-Majorana expression. For hyperbolic secant pulses, the Demkov-Kunike model describes excitation for spin packets within and outside the sweep range. Well within the sweep range, the Bloch-Siegert phase shift is proportional to critical adiabaticity to a very good approximation. Because of the dependence of both flip angle and coherence phase on critical adiabaticity, it is advantageous to use pairs of amplitude and frequency modulation functions that provide such offset-independent adiabaticity. Compensation for the resonator response function should restore offset-independent adiabaticity. Whereas resonance offsets and Bloch-Siegert phase can be refocused at certain pulse length ratios, phase dispersion in coupled spin systems cannot generally be refocused. Based on the bandwidth limitations that arise from spin dynamics, requirements are derived for a spectrometer that achieves precise spin control over wide bands. The design of such a spectrometer and hardware characterization by EPR experiments are discussed.

  19. A high voltage nanosecond pulser with independently adjustable output voltage, pulse width, and pulse repetition frequency

    NASA Astrophysics Data System (ADS)

    Prager, James; Ziemba, Timothy; Miller, Kenneth; Carscadden, John; Slobodov, Ilia

    2014-10-01

    Eagle Harbor Technologies (EHT) is developing a high voltage nanosecond pulser capable of generating microwaves and non-equilibrium plasmas for plasma medicine, material science, enhanced combustion, drag reduction, and other research applications. The EHT nanosecond pulser technology is capable of producing high voltage (up to 60 kV) pulses (width 20-500 ns) with fast rise times (<10 ns) at high pulse repetition frequency (adjustable up to 100 kHz) for CW operation. The pulser does not require the use of saturable core magnetics, which allows for the output voltage, pulse width, and pulse repetition frequency to be fully adjustable, enabling researchers to explore non-equilibrium plasmas over a wide range of parameters. A magnetic compression stage can be added to improve the rise time and drive lower impedance loads without sacrificing high pulse repetition frequency operation. Work supported in part by the US Navy under Contract Number N00014-14-P-1055 and the US Air Force under Contract Number FA9550-14-C-0006.

  20. Physics characterization and frequency stability of the pulsed rubidium maser

    SciTech Connect

    Godone, Aldo; Micalizio, Salvatore; Levi, Filippo; Calosso, Claudio

    2006-10-15

    In this paper we report the theoretical and experimental characterization of a pulsed optically pumped vapor-cell frequency standard based on the detection of the free-induction decay microwave signal. The features that make this standard similar to a pulsed passive maser are presented. In order to predict and optimize the frequency stability, thermal and shot noise sources are analyzed, as well as the conversions of the laser and microwave fluctuations into the output frequency. The experimental results obtained with a clock prototype based on {sup 87}Rb in buffer gas are compared with the theoretical predictions, showing the practical possibility to implement a frequency standard limited in the medium term only by thermal drift. The achieved frequency stability is {sigma}{sub y}({tau})=1.2x10{sup -12}{tau}{sup -1/2} for measurement times up to {tau}{approx_equal}10{sup 5} s. It represents one of the best results reported in literature for gas cell frequency standards and is compliant with the present day requirements for on board space applications.

  1. Radio-Frequency Pulse Compression for Linear Accelerators.

    NASA Astrophysics Data System (ADS)

    Nantista, Christopher Dennis

    Recent efforts to develop plans for an electron -positron linear collider with center-of-mass energy approaching a TeV have highlighted the need for sources capable of delivering hundreds of megawatts of peak rf drive power at X-band frequencies. This need has driven work in the area of rf pulse compression, which enhances the peak power available from pulsed rf tubes by compressing their output pulses in time, accumulating the available energy into shorter pulses. The classic means of rf pulse compression for linear accelerators is SLED. This technique is described, and the problem it presents for multibunch acceleration explained. Other pulse compression schemes, capable of producing suitable output pulses are explored, both theoretically and experimentally, in particular Binary Pulse Compression and SLED-II. The merits of each are considered with regard to gain, efficiency, complexity, size and cost. The development of some novel system components, along with the theory behind their design, is also discussed. The need to minimize copper losses in long waveguide runs led to the use of the circular TE_{01} propagation mode in over-moded guide, requiring much attention to mechanisms of coupling power between modes. The construction and commissioning of complete, high-power pulse compression systems is reported on, as well as their use in the testing of X-band accelerating structures, which, along with the X-band klystrons used, were developed at SLAC in parallel with the pulse compression work. The focus of the dissertation is on SLED-II, the favored scheme in some current linear accelerator designs. In addition to our experimental results, practical implementation considerations and design improvements are presented. The work to date has led to detailed plans for SLED-II systems to be used in the Next Linear Collider Test Accelerator, now under construction at SLAC. The prototype of the upgraded system is near completion. Descriptions of various rf pulse

  2. Frequency conversion of high-intensity, femtosecond laser pulses

    SciTech Connect

    Banks, P S

    1997-06-01

    Almost since the invention of the laser, frequency conversion of optical pulses via non- linear processes has been an area of active interest. However, third harmonic generation using ~(~1 (THG) in solids is an area that has not received much attention because of ma- terial damage limits. Recently, the short, high-intensity pulses possible with chirped-pulse amplification (CPA) laser systems allow the use of intensities on the order of 1 TW/cm2 in thin solids without damage. As a light source to examine single-crystal THG in solids and other high field inter- actions, the design and construction of a Ti:sapphire-based CPA laser system capable of ultimately producing peak powers of 100 TW is presented. Of special interest is a novel, all-reflective pulse stretcher design which can stretch a pulse temporally by a factor of 20,000. The stretcher design can also compensate for the added material dispersion due to propagation through the amplifier chain and produce transform-limited 45 fs pulses upon compression. A series of laser-pumped amplifiers brings the peak power up to the terawatt level at 10 Hz, and the design calls for additional amplifiers to bring the power level to the 100 TW level for single shot operation. The theory for frequency conversion of these short pulses is presented, focusing on conversion to the third harmonic in single crystals of BBO, KD*P, and d-LAP (deuterated I-arginine phosphate). Conversion efficiencies of up to 6% are obtained with 500 fs pulses at 1053 nm in a 3 mm thick BBO crystal at 200 GW/cm 2. Contributions to this process by unphasematched, cascaded second harmonic generation and sum frequency generation are shown to be very significant. The angular relationship between the two orders is used to measure the tensor elements of C = xt3)/4 with Crs = -1.8 x 1O-23 m2/V2 and .15Cri + .54Crs = 4.0 x 1O-23 m2/V2. Conversion efficiency in d-LAP is about 20% that in BBO and conversion efficiency in KD*P is 1% that of BBO. It is calculated

  3. Fast Rise Time and High Voltage Nanosecond Pulses at High Pulse Repetition Frequency

    NASA Astrophysics Data System (ADS)

    Miller, Kenneth E.; Ziemba, Timothy; Prager, James; Picard, Julian; Hashim, Akel

    2015-09-01

    Eagle Harbor Technologies (EHT), Inc. is conducting research to decrease the rise time and increase the output voltage of the EHT Nanosecond Pulser product line, which allows for independently, user-adjustable output voltage (0 - 20 kV), pulse width (20 - 500 ns), and pulse repetition frequency (0 - 100 kHz). The goals are to develop higher voltage pulses (50 - 60 kV), decrease the rise time from 20 to below 10 ns, and maintain the high pulse repetition capabilities. These new capabilities have applications to pseudospark generation, corona production, liquid discharges, and nonlinear transmission line driving for microwave production. This work is supported in part by the US Navy SBIR program.

  4. Terahertz metrology on power, frequency, spectroscopy, and pulse parameters

    NASA Astrophysics Data System (ADS)

    Wu, Bin; Ying, Cheng Ping; Wang, Heng Fei; Zhang, Peng; Liu, Hong Yuan; Jiang, Bin

    2015-11-01

    Terahertz metrology is becoming more and more important along with the fast development of terahertz technology. This paper reviews the research works of the groups from the physikalisch-technische bundesanstalt (PTB), National institute of standards and technology (NIST), National physical laboratory (NPL), National institute of metrology (NIM) and some other research institutes. The contents mainly focus on the metrology of parameters of power, frequency, spectrum and pulse. At the end of the paper, the prospect of terahertz metrology is predicted.

  5. High frequency optical pulse generation by frequency doubling using polarization rotation

    NASA Astrophysics Data System (ADS)

    Liu, Yang

    2016-05-01

    In this work, we propose and experimentally characterize a stable 40 GHz optical pulse generation by frequency doubling using polarization rotation in a phase modulator (PM). Only half the electrical driving frequency is required (i.e. 20 GHz); hence the deployment cost can be reduced. Besides, precise control of the bias of the PM is not required. The generated optical pulses have a high center-mode-suppression-ratio (CMSR) of  >  28 dB. The single sideband (SSB) noise spectrum is also measured, and the time-domain waveforms under different CMSRs are also analyzed and discussed.

  6. Nonlinear currents generated in plasma by a radiation pulse with a frequency exceeding the electron plasma frequency

    SciTech Connect

    Grishkov, V. E.; Uryupin, S. A.

    2016-09-15

    It is shown that the nonlinear currents generated in plasma by a radiation pulse with a frequency exceeding the electron plasma frequency change substantially due to a reduction in the effective electron–ion collision frequency.

  7. Exponential frequency spectrum and Lorentzian pulses in magnetized plasmas

    SciTech Connect

    Pace, D. C.; Shi, M.; Maggs, J. E.; Morales, G. J.; Carter, T. A.

    2008-12-15

    Two different experiments involving pressure gradients across the confinement magnetic field in a large plasma column are found to exhibit a broadband turbulence that displays an exponential frequency spectrum for frequencies below the ion cyclotron frequency. The exponential feature has been traced to the presence of solitary pulses having a Lorentzian temporal signature. These pulses arise from nonlinear interactions of drift-Alfven waves driven by the pressure gradients. In both experiments the width of the pulses is narrowly distributed resulting in exponential spectra with a single characteristic time scale. The temporal width of the pulses is measured to be a fraction of a period of the drift-Alfven waves. The experiments are performed in the Large Plasma Device (LAPD-U) [W. Gekelman et al., Rev. Sci. Instrum. 62, 2875 (1991)] operated by the Basic Plasma Science Facility at the University of California, Los Angeles. One experiment involves a controlled, pure electron temperature gradient associated with a microscopic (6 mm gradient length) hot electron temperature filament created by the injection a small electron beam embedded in the center of a large, cold magnetized plasma. The other experiment is a macroscopic (3.5 cm gradient length) limiter-edge experiment in which a density gradient is established by inserting a metallic plate at the edge of the nominal plasma column of the LAPD-U. The temperature filament experiment permits a detailed study of the transition from coherent to turbulent behavior and the concomitant change from classical to anomalous transport. In the limiter experiment the turbulence sampled is always fully developed. The similarity of the results in the two experiments strongly suggests a universal feature of pressure-gradient driven turbulence in magnetized plasmas that results in nondiffusive cross-field transport. This may explain previous observations in helical confinement devices, research tokamaks, and arc plasmas.

  8. Phase and intensity characterization of femtosecond pulses from a chirped-pulse amplifier by frequency-resolved optical gating

    SciTech Connect

    Kohler, B.; Yakovlev, V.V.; Wilson, K.R.; Squier, J.; DeLong, K.W.; Trebino, R.

    1995-03-01

    Frequency-resolved optical gating (FROG) measurements were made to characterize pulses from a Ti:sapphire chirped-pulse amplified laser system. By characterizing both the pulse intensity and the phase, the FROG data provided the first direct observation to our knowledge of residual phase distortion in a chirped-pulse amplifier. The FROG technique was also used to measure the regenerative amplifier dispersion and to characterize an amplitude-shaped pulse. The data provide an experimental demonstration of the value of FROG for characterizing complex pulses, including tailored femtosecond pulses for quantum control.

  9. Single pulse frequency compounding protocol for superharmonic imaging

    NASA Astrophysics Data System (ADS)

    Danilouchkine, M. G.; van Neer, P. L. M. J.; Verweij, M. D.; Matte, G. M.; Vletter, W. B.; van der Steen, A. F. W.; de Jong, N.

    2013-07-01

    Second harmonic imaging is currently accepted as the standard in commercial echographic systems. A new imaging technique, coined as superharmonic imaging (SHI), combines the third till the fifth harmonics, arising during nonlinear sound propagation. It could further enhance the resolution and quality of echographic images. To meet the bandwidth requirement for SHI a dedicated phased array has been developed: a low frequency subarray, intended for transmission, interleaved with a high frequency subarray, used in reception. As the bandwidth of the elements is limited, the spectral gaps in between the harmonics cause multiple (ghost) reflection artifacts. A dual-pulse frequency compounding method aims at suppressing those artifacts at a price of a reduced frame rate. In this study we explore a possibility of performing frequency compounding within a single transmission. The traditional frequency compounding method suppresses the ripples by consecutively emitting two short Gaussian bursts with a slightly different center frequency. In the newly proposed method, the transmit aperture is divided into two parts: the first half is used to send a pulse at the lower center frequency, while the other half simultaneously transmits at a slightly higher center frequency. The suitability of the protocol for medical imaging applications in terms of the steering capabilities was performed in a simulation study with INCS and the hydrophone measurements. Moreover, an experimental study was carried out to find the optimal parameters for the clinical imaging protocol. The latter was subsequently used to obtain the images of a tissue mimicking phantom containing strongly reflecting wires. Additionally, the images of a human heart in the parasternal projection were acquired. The scanning aperture with the developed protocol amounts to approximately 90°, which is sufficient to capture the cardiac structures in the standard anatomical projections. The theoretically estimated and

  10. Electron heating enhancement by frequency-chirped laser pulses

    NASA Astrophysics Data System (ADS)

    Yazdani, E.; Sadighi-Bonabi, R.; Afarideh, H.; Riazi, Z.; Hora, H.

    2014-09-01

    Propagation of a chirped laser pulse with a circular polarization through an uprising plasma density profile is studied by using 1D-3V particle-in-cell simulation. The laser penetration depth is increased in an overdense plasma compared to an unchirped pulse. The induced transparency due to the laser frequency chirp results in an enhanced heating of hot electrons as well as increased maximum longitudinal electrostatic field at the back side of the solid target, which is very essential in target normal sheath acceleration regime of proton acceleration. For an applied chirp parameter between 0.008 and 0.01, the maximum amount of the electrostatic field is improved by a factor of 2. Furthermore, it is noticed that for a chirped laser pulse with a0 = 5, because of increasing the plasma transparency length, the laser pulse can penetrate up to about ne ≈ 6nc, where nc is plasma critical density. It shows 63% increase in the effective critical density compared to the relativistic induced transparency regime for an unchirped condition.

  11. Electron heating enhancement by frequency-chirped laser pulses

    SciTech Connect

    Yazdani, E.; Afarideh, H.; Sadighi-Bonabi, R.; Riazi, Z.; Hora, H.

    2014-09-14

    Propagation of a chirped laser pulse with a circular polarization through an uprising plasma density profile is studied by using 1D-3V particle-in-cell simulation. The laser penetration depth is increased in an overdense plasma compared to an unchirped pulse. The induced transparency due to the laser frequency chirp results in an enhanced heating of hot electrons as well as increased maximum longitudinal electrostatic field at the back side of the solid target, which is very essential in target normal sheath acceleration regime of proton acceleration. For an applied chirp parameter between 0.008 and 0.01, the maximum amount of the electrostatic field is improved by a factor of 2. Furthermore, it is noticed that for a chirped laser pulse with a₀=5, because of increasing the plasma transparency length, the laser pulse can penetrate up to about n{sub e}≈6n{sub c}, where n{sub c} is plasma critical density. It shows 63% increase in the effective critical density compared to the relativistic induced transparency regime for an unchirped condition.

  12. 10 K high frequency pulse tube cryocooler with precooling

    NASA Astrophysics Data System (ADS)

    Liu, Sixue; Chen, Liubiao; Wu, Xianlin; Zhou, Yuan; Wang, Junjie

    2016-07-01

    A high frequency pulse tube cryocooler with precooling (HPTCP) has been developed and tested to meet the requirement of weak magnetic signals measurement, and the performance characteristics are presented in this article. The HPTCP is a two-stage pulse tube cryocooler with the precooling-stage replaced by liquid nitrogen. Two regenerators completely filled with stainless steel (SS) meshes are used in the cooler. Together with cold inertance tubes and cold gas reservoir, a cold double-inlet configuration is used to control the phase relationship of the HPTCP. The experimental result shows that the cold double-inlet configuration has improved the performance of the cooler obviously. The effects of operation parameters on the performance of the cooler are also studied. With a precooling temperature of 78.5 K, the maximum refrigeration capacity is 0.26 W at 15 K and 0.92 W at 20 K when the input electric power are 174 W and 248 W respectively, and the minimum no-load temperature obtained is 10.3 K, which is a new record on refrigeration temperature for high frequency pulse tube cryocooler reported with SS completely used as regenerative matrix.

  13. Duobinary pulse shaping for frequency chirp enabled complex modulation.

    PubMed

    Che, Di; Yuan, Feng; Khodakarami, Hamid; Shieh, William

    2016-09-01

    The frequency chirp of optical direct modulation (DM) used to be a performance barrier of optical transmission system, because it broadens the signal optical spectrum, which becomes more susceptible to chromatic dispersion induced inter-symbol interference (ISI). However, by considering the chirp as frequency modulation, the single DM simultaneously generates a 2-D signal containing the intensity and phase (namely, the time integral of frequency). This complex modulation concept significantly increases the optical signal to noise ratio (OSNR) sensitivity of DM systems. This Letter studies the duobinary pulse shaping (DB-PS) for chirp enabled DM and its impact on the optical bandwidth and system OSNR sensitivity. DB-PS relieves the bandwidth requirement, at the sacrifice of system OSNR sensitivity. As DB-PS induces a controlled ISI, the receiver requires one more tap for maximum likelihood sequence estimation (MLSE). We verify this modified MLSE with a 10-Gbaud duobinary PAM-4 transmission experiment.

  14. Multi-pulse frequency shifted (MPFS) multiple access modulation for ultra wideband

    DOEpatents

    Nekoogar, Faranak [San Ramon, CA; Dowla, Farid U [Castro Valley, CA

    2012-01-24

    The multi-pulse frequency shifted technique uses mutually orthogonal short duration pulses o transmit and receive information in a UWB multiuser communication system. The multiuser system uses the same pulse shape with different frequencies for the reference and data for each user. Different users have a different pulse shape (mutually orthogonal to each other) and different transmit and reference frequencies. At the receiver, the reference pulse is frequency shifted to match the data pulse and a correlation scheme followed by a hard decision block detects the data.

  15. Frequency stabilization in injection controlled pulsed CO2 lasers

    NASA Technical Reports Server (NTRS)

    Menzies, Robert T.; Ancellet, Gerard M.

    1987-01-01

    Longitudinal mode selection by injection has been demonstrated as a viable technique for tailoring a TEA-CO2 laser with pulse energies of a Joule or greater to fit the requirements of a coherent lidar transmitter. Once reliable generation of single-longitudinal-mode (SLM) pulses is obtained, one can study the intrapulse frequency variation and attempt to determine the sources of frequency sweeping, or chirp. These sources include the effect of the decaying plasma, the thermal gradient due to the energy dissipation associated with the laser mechanism itself, and the pressure shift of the center frequency of the laser transition. The use of the positive-branch unstable resonator as an efficient means of coupling a discharge with transverse spatial dimensions of the order of centimeters to an optical cavity mode introduces another concern: namely, what can be done to emphasize transverse mode discrimination in an unstable resonator cavity while maintaining high coupling efficiency. These issues are briefly discussed in the paper, and representative experimental examples are included.

  16. Flexible radio-frequency photonics: Optoelectronic frequency combs and integrated pulse shaping

    NASA Astrophysics Data System (ADS)

    Metcalf, Andrew J.

    Microwave photonics is a discipline which leverages optoelectronics to enhance the generation, transport, and processing of high-frequency electrical signals. At the heart of many emerging techniques is the optical frequency comb. A comb is a lightwave source whose spectrum is made up of discrete equally spaced spectral components that share a fixed phase relationship. These discrete coherent oscillators --known as comb lines-- collectively form a Fourier basis that describe a periodic optical waveform. Within the last two decades frequency-stabilized broadband combs produced from mode-locked lasers have led to revolutionary advancements in precision optical frequency synthesis and metrology. Meanwhile, Fourier-transform optical pulse shaping, which provides a means to control a comb's Fourier basis in both amplitude and phase, has emerged as an integral tool in optical communications, broadband waveform generation, and microwave photonic filtering. However, traditional comb and pulse shaping architectures are often plagued by complex and bulky setups, rendering robust and cost effective implementation outside of the laboratory a challenge. In addition, traditional comb sources based on short-pulse lasers do not possess qualities which are ideally suited for this new application regime. Motivated by the shortcomings in current architectures, and empowered by recent advancements in optoelectronic technology, this dissertation focuses on developing novel and robust schemes in optical frequency comb generation and line-by-line pulse shaping. Our results include: the invention and low-noise characterization of a broadband flat-top comb source; the realization of an optoelectronic-based time cloak; and finally, the development of an integrated pulse shaper, which we use in conjunction with our flat-top comb source to demonstrate a rapidly reconfigurable microwave photonic filter.

  17. Modeling and High-Throughput Experimental Data Uncover the Mechanisms Underlying Fshb Gene Sensitivity to Gonadotropin-Releasing Hormone Pulse Frequency.

    PubMed

    Stern, Estee; Ruf-Zamojski, Frederique; Zalepa-King, Lisa; Pincas, Hanna; Choi, Soon Gang; Peskin, Charles S; Fernand, Hayot; Turgeon, Judith L; Sealfon, Stuart C

    2017-04-06

    Neuroendocrine control of reproduction by brain-secreted pulses of gonadotropin-releasing hormone (GnRH) represents a longstanding puzzle about extracellular signal decoding mechanisms. GnRH regulates the pituitary gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH), both of which are heterodimers specified by unique β subunits (FSHβ/LHβ). Contrary to Lhb, Fshb gene induction has a preference for low frequency GnRH pulses. To clarify the underlying regulatory mechanisms, we developed three biologically anchored mathematical models: 1) parallel activation of Fshb inhibitory factors (e.g. inhibin α and VGF nerve growth factor-inducible), 2) activation of a signaling component with a refractory period (e.g. G protein), and 3) inactivation of a factor needed for Fshb induction (e.g. growth differentiation factor 9). Simulations with all three models recapitulated the Fshb expression levels obtained in pituitary gonadotrope cells perifused with varying GnRH pulse frequencies. Notably, simulations altering average concentration, pulse duration, and pulse frequency revealed that the apparent frequency-dependent pattern of Fshb expression in model 1 actually resulted from variations in average GnRH concentration. In contrast, models 2 and 3 showed »true» pulse frequency sensing. To resolve which components of this GnRH signal induce Fshb, we developed a high-throughput parallel experimental system. We analyzed over 4,000 samples in experiments with varying near-physiological GnRH concentrations and pulse patterns. While Egr1 and Fos genes responded only to variations in average GnRH concentration, Fshb levels were sensitive to both average concentration and true pulse frequency. These results provide a foundation for understanding the role of multiple regulatory factors in modulating Fshb gene activity.

  18. Single pulse frequency compounding protocol for superharmonic imaging

    NASA Astrophysics Data System (ADS)

    Danilouchkine, Mikhail G.; van Neer, Paul L. M. J.; Matte, Guillaume M.; Verweij, Martin D.; de Jong, Nico

    2011-03-01

    Second harmonic imaging is currently adopted as standard in commercial echographic systems. A new imaging technique, coined as superharmonic imaging (SHI), combines the 3rd till the 5th harmonics, arising during nonlinear sound propagation. It could further enhance resolution and quality of echographic images. To meet the bandwidth requirement for SHI a dedicated phased array has been developed: a low frequency subarray, intended for transmission, interleaved with a high frequency subarray, used in reception. As the bandwidth of the elements is limited, the spectral gaps in between the harmonics cause multiple reflection artifacts. Recently, we introduce a dual-pulse frequency compounding (DPFC) method to suppress those artifacts at price of a reduced frame rate. In this study we investigate the feasibility of performing the frequency compounding protocol within a single transmission. The traditional DPFC method constructs each trace in a post-processing stage by summing echoes from two emitted pulses, the second slightly frequency-shifted compared to the first. In the newly proposed method, the transmit aperture is divided into two parts: the first half is used to send a pulse at the lower center frequency, while the other half simultaneously transmits at the higher center frequency. The suitability of the protocol for medical imaging applications in terms of the steering capabilities was performed in a simulation study using the FIELD II toolkit. Moreover, an experimental study was performed to deduce the optimal parametric set for implementation of the clinical imaging protocol. The latter was subsequently used to obtain the images of a tissue mimicking phantom containing strongly reflecting wires. For in-vitro acquisitions the SHI probe with interleaved phased array (44 odd elements at 1MHz and 44 even elements at 3.7MHz elements, optimized for echocardiography) was connected to a fully programmable ultrasound system. The results of the Field II simulations

  19. Effects of pulse frequency on the microstructure, composition and optical properties of pulsed dc reactively sputtered vanadium oxide thin films

    NASA Astrophysics Data System (ADS)

    Dong, Xiang; Wu, Zhiming; Jiang, Yadong; Xu, Xiangdong; Yu, He; Gu, Deen; Wang, Tao

    2014-09-01

    Vanadium oxide (VOx) thin films were prepared on unheated glass substrate by pulsed dc reactive magnetron sputtering using different pulse frequency. Field emission scanning electron microscopy (FESEM), x-ray photoelectron spectroscopy (XPS) and spectroscopic ellipsometry (SE) measurements were made on the deposited VOx films to characterize the microstructure, composition and optical properties, respectively. It was found that under the same discharge power and argon-oxygen atmosphere, with the increase of pulse frequency, the vertical column-like structure in the films will gradually disappear and the ratio of high-valent VOx to low-valent VOx will obviously elevate. Optical parameters of the VOx films have been obtained by fitting the ellipsometric data (Ψ andΔ) using the Tauc-Lorentz dispersion relation and a multilayer model (air/roughness layer/VOx/glass). The results demonstrated that pulse frequency plays a critical role in determining the transmittance, refractive index, extinction coefficient and optical band gap etc. The correlations between the microstructure, composition, optical properties and pulse frequency are also given by our experiment results. And the mechanisms for the evolution of the microstructure, composition and optical properties with pulse frequency have been discussed. Overall, due to the pulse frequency had a great effect not only on the growth characteristics but also on the optical properties of the VOx films, thus through variation of the pulse frequency during deposition which provide a convenient and efficient approach to control and optimize the performances of the VOx films.

  20. SAR imagery using chaotic carrier frequency agility pulses

    NASA Astrophysics Data System (ADS)

    Xu, Xiaojian; Feng, Xiangzhi

    2011-06-01

    Synthetic aperture radar (SAR) systems are getting more and more applications in both civilian and military remote sensing missions. With the increasing deployment of electronic countermeasures (ECM) on modern battlefields, SAR encounters more and more interference jamming signals. The ECM jamming signals cause the SAR system to receive and process erroneous information which results in severe degradations in the output SAR images and/or formation of phony images of nonexistent targets. As a consequence, development of the electronic counter-countermeasures (ECCM) capability becomes one of the key problems in SAR system design. This paper develops radar signaling strategies and algorithms that enhance the ability of synthetic aperture radar to image targets under conditions of electronic jamming. The concept of SAR using chaotic carrier frequency agility pulses (CCFAP-SAR) is first proposed. Then the imaging procedure for CCFAP-SAR is discussed in detail. The ECCM performance of CCFAP-SAR for both depressive noise jamming and deceptive repeat jamming is analyzed. The impact of the carrier frequency agility range on the image quality of CCFAP-SAR is also studied. Simulation results demonstrate that, with adequate agility range of the carrier frequency, the proposed CCFAP-SAR performs as well as conventional radar with linear frequency modulation (LFM) waveform in image quality and slightly better in anti-noise depressive jamming; while performs very well in anti-deception jamming which cannot be rejected by LFM-SAR.

  1. Sub-15fs ultraviolet pulses generated by achromatic phase-matching sum-frequency mixing.

    PubMed

    Zhao, Baozhen; Jiang, Yongliang; Sueda, Keiich; Miyanaga, Noriaki; Kobayashi, Takayoshi

    2009-09-28

    A broadband ultraviolet pulse with a spectral width of 44 nm was generated by achromatic sum-frequency mixing of an 805-nm pulse and ultrabroadband visible pulse. Angular dispersion was introduced to achieve broadband phase matching by a prism pair. The UV pulse was compressed to 13.2 fs with another prism pair, with energy of 600 nJ.

  2. State dependent model predictive control for orbital rendezvous using pulse-width pulse-frequency modulated thrusters

    NASA Astrophysics Data System (ADS)

    Li, Peng; Zhu, Zheng H.; Meguid, S. A.

    2016-07-01

    This paper studies the pulse-width pulse-frequency modulation based trajectory planning for orbital rendezvous and proximity maneuvering near a non-cooperative spacecraft in an elliptical orbit. The problem is formulated by converting the continuous control input, output from the state dependent model predictive control, into a sequence of pulses of constant magnitude by controlling firing frequency and duration of constant-magnitude thrusters. The state dependent model predictive control is derived by minimizing the control error of states and control roughness of control input for a safe, smooth and fuel efficient approaching trajectory. The resulting nonlinear programming problem is converted into a series of quadratic programming problem and solved by numerical iteration using the receding horizon strategy. The numerical results show that the proposed state dependent model predictive control with the pulse-width pulse-frequency modulation is able to effectively generate optimized trajectories using equivalent control pulses for the proximity maneuvering with less energy consumption.

  3. GnRH Pulse Frequency Control of Fshb Gene Expression Is Mediated via ERK1/2 Regulation of ICER.

    PubMed

    Thompson, Iain R; Ciccone, Nick A; Zhou, Qiongjie; Xu, Shuyun; Khogeer, Ahmad; Carroll, Rona S; Kaiser, Ursula B

    2016-03-01

    The pulsatile release of GnRH regulates the synthesis and secretion of pituitary FSH and LH. Two transcription factors, cAMP-response element-binding protein (CREB) and inducible cAMP early repressor (ICER), have been implicated in the regulation of rat Fshb gene expression. We previously showed that the protein kinase A pathway mediates GnRH-stimulated CREB activation. We hypothesized that CREB and ICER are activated by distinct signaling pathways in response to pulsatile GnRH to modulate Fshb gene expression, which is preferentially stimulated at low vs high pulse frequencies. In the LβT2 gonadotrope-derived cell line, GnRH stimulation increased ICER mRNA and protein. Blockade of ERK activation with mitogen-activated protein kinase kinase I/II (MEKI/II) inhibitors significantly attenuated GnRH induction of ICER mRNA and protein, whereas protein kinase C, calcium/calmodulin-dependent protein kinase II, and protein kinase A inhibitors had minimal effects. GnRH also stimulated ICER in primary mouse pituitary cultures, attenuated similarly by a MEKI/II inhibitor. In a perifusion paradigm, MEKI/II inhibition in LβT2 cells stimulated with pulsatile GnRH abrogated ICER induction at high GnRH pulse frequencies, with minimal effect at low frequencies. MEKI/II inhibition reduced GnRH stimulation of Fshb at high and low pulse frequencies, suggesting that the ERK pathway has additional effects on GnRH regulation of Fshb, beyond those mediated by ICER. Indeed, induction of the activating protein 1 proteins, cFos and cJun, positive modulators of Fshb transcription, by pulsatile GnRH was also abrogated by inhibition of the MEK/ERK signaling pathway. Collectively, these studies indicate that the signaling pathways mediating GnRH activation of CREB and ICER are distinct, contributing to the decoding of the pulsatile GnRH to regulate FSHβ expression.

  4. Different pulse pattern generation by frequency detuning in pulse modulated actively mode-locked ytterbium doped fiber laser

    NASA Astrophysics Data System (ADS)

    Chen, He; Chen, Sheng-Ping; Si, Lei; Zhang, Bin; Jiang, Zong-Fu

    2015-10-01

    We report the results of our recent experimental investigation of the modulation frequency detuning effect on the output pulse dynamics in a pulse modulated actively mode-locked ytterbium doped fiber laser. The experimental study shows the existence of five different mode-locking states that mainly depend on the modulation frequency detuning, which are: (a) amplitude-even harmonic/fundamental mode-locking, (b) Q-switched harmonic/fundamental mode-locking, (c) sinusoidal wave modulation mode, (d) pulses bundle state, and (e) noise-like state. A detailed experimental characterization of the output pulses dynamics in each operating mode is presented.

  5. The Impact of Reduced Pulse Oximetry Use on Alarm Frequency.

    PubMed

    Schondelmeyer, Amanda C; Brady, Patrick W; Sucharew, Heidi; Huang, Guixia; Hofacer, Kelsey E; Simmons, Jeffrey M

    2016-04-01

    Concerns about alarm fatigue prompted The Joint Commission to issue a Sentinel Event Alert urging hospitals to minimize alarms. We previously conducted a quality improvement project on a single unit that reduced time on continuous pulse oximetry, a common source of physiologic monitor alarms, for patients with wheezing (ie, asthma and bronchiolitis, wheezing-associated respiratory infections). To study the impact of our improvement work on overall physiologic monitor alarm frequency for these patients. This was a retrospective cohort study at a freestanding children's hospital over an 8-week period. We compared alarm count, including respiratory, cardiac, and pulse oximetry alarms, for patients admitted to the intervention unit with the alarm count for similar patients on a control unit by using the Wilcoxon rank sum test. We used negative binomial regression to evaluate differences in alarm count between the units, adjusting for age, medical comorbidity, and length of stay. There were 101 patients on the intervention unit and 46 patients on the control unit. The percentage of patients with medical comorbidities was significantly higher on the intervention unit (P=.01). Median alarm count per day for patients on the intervention unit was lower; however, this difference was not statistically significant (71 vs 76 alarms per patient-day, P=.29). The multivariable model estimated a nonsignificant 6.4-count decrease in alarms for patients on the intervention unit. Reducing continuous pulse oximetry use alone may not make substantial reductions in overall alarm counts. Even on our intervention unit, alarm burden remained quite high. Copyright © 2016 by the American Academy of Pediatrics.

  6. Low frequency acoustic pulse propagation in temperate forests.

    PubMed

    Albert, Donald G; Swearingen, Michelle E; Perron, Frank E; Carbee, David L

    2015-08-01

    Measurements of acoustic pulse propagation for a 30-m path were conducted in an open field and in seven different forest stands in the northeastern United States consisting of deciduous, evergreen, or mixed tree species. The waveforms recorded in forest generally show the pulse elongation characteristic of propagation over a highly porous ground surface, with high frequency scattered arrivals superimposed on the basic waveform shape. Waveform analysis conducted to determine ground properties resulted in acoustically determined layer thicknesses of 4-8 cm in summer, within 2 cm of the directly measured thickness of the litter layers. In winter the acoustic thicknesses correlated with the site-specific snow cover depths. Effective flow resistivity values of 50-88 kN s m(-4) were derived for the forest sites in summer, while lower values typical for snow were found in winter. Reverberation times (T60) were typically around 2 s, but two stands (deciduous and pruned spruce planted on a square grid) had lower values of about 1.2 s. One site with a very rough ground surface had very low summer flow resistivity value and also had the longest reverberation time of about 3 s. These measurements can provide parameters useful for theoretical predictions of acoustic propagation within forests.

  7. Discrete pulse modulation strategies for high-frequency inverter systems

    SciTech Connect

    Venkataramanan, G. . Dept. of Electrical Engineering); Divan, D.M. . Dept. of Electrical and Computer Engineering); Jahns, T.M. )

    1993-07-01

    High-performance high-frequency inverter systems for UPS applications represent a demanding application that cannot be easily realized using conventional hard-switched PWM inverter topologies. Adoption of typical soft-switched inverters such as the resonant dc link inverter require the use of discrete pulse modulation strategies. New controller structures are necessary to cope with stringent voltage regulation and distortion constraints in the presence of unbalanced and nonlinear loads. This paper presents a controller that utilizes load current feed-forward strategy with a cost function current regulator to achieve excellent transient performance characteristics. Voltage regulation is ensured using a synchronous frame regulator. Detailed simulation and experimental results verifying the concepts are presented. Although this paper focuses on soft-switching inverters, the control concepts can be applied to conventional hard-switching inverters as well.

  8. Discrete pulse modulation strategies for high-frequency inverter systems

    NASA Astrophysics Data System (ADS)

    Venkataramanan, Giri; Divan, Deepakraj M.; Jahns, Thomas M.

    1993-07-01

    High-performance, high-frequency inverter systems for UPS (uninterruptible power system) applications cannot be easily realized using conventional hard-switched PWM inverter topologies. Adoption of typical soft-switched inverters such as the resonant dc link inverter require the use of discrete pulse modulation strategies. New controller structures are necessary to cope with stringent voltage regulation and distortion constraints in the presence of unbalanced and nonlinear loads. A controller that utilizes a load current feedforward strategy with a cost function current regulator to achieve excellent transient performance characteristics is presented. Voltage regulation is ensured using a synchronous frame regulator. Detailed simulation and experimental results verifying the concepts are presented. Although this work focuses on soft-switching inverters, the control concepts can be applied to conventional hard-switching inverters as well.

  9. The relationship between rate of venous sampling and visible frequency of hormone pulses.

    PubMed

    De Nicolao, G; Guardabasso, V; Rocchetti, M

    1990-11-01

    In this paper, a stochastic model of episodic hormone secretion is used to quantify the effect of the sampling rate on the frequency of pulses that can be detected by objective computer methods in time series of plasma hormone concentrations. Occurrence times of secretion pulses are modeled as recurrent events, with interpulse intervals described by Erlang distributions. In this way, a variety of secretion patterns, ranging from Poisson events to periodic pulses, can be studied. The notion of visible and invisible pulses is introduced and the relationship between true pulses frequency and mean visible pulse frequency is analytically derived. It is shown that a given visible pulse frequency can correspond to two distinct true frequencies. In order to compensate for the 'invisibility error', an algorithm based on the analysis of the original series and its undersampled subsets is proposed and the derived computer program is tested on simulated and clinical data.

  10. Ultrashort-pulse measurement using noninstantaneous nonlinearities: Raman effects in frequency-resolved optical gating.

    PubMed

    Delong, K W; Ladera, C L; Trebino, R; Kohler, B; Wilson, K R

    1995-03-01

    Ultrashort-pulse-characterization techniques generally require instantaneously responding media. We show that this is not the case for frequency-resolved optical gating (FROG). We include, as an example, the noninstantaneous Raman response of fused silica, which can cause errors in the retrieved pulse width of as much as 8% for a 25-fs pulse in polarization-gate FROG. We present a modified pulse-retrieval algorithm that deconvolves such slow effects and use it to retrieve pulses of any width. In experiments with 45-fs pulses this algorithm achieved better convergence and yielded a shorter pulse than previous FROG algorithms.

  11. Ultrashort-pulse measurement using noninstantaneous nonlinearities: Raman effects in frequency-resolved optical gating

    SciTech Connect

    DeLong, K.W.; Ladera, C.L.; Trebino, R.; Kohler, B.; Wilson, K.R.

    1995-03-01

    Ultrashort-pulse-characterization techniques generally require instantaneously responding media. We show that this is not the case for frequency-resolved optical gating (FROG). We include, as an example, the noninstantaneous Raman response of fused silica, which can cause errors in the retrieved pulse width of as much as 8% for a 25-fs pulse in polarization-gate FROG. We present a modified pulse-retrieval algorithm that deconvolves such slow effects and use it to retrieve pulses of any width. In experiments with 45-fs pulses this algorithm achieved better convergence and yielded a shorter pulse than previous FROG algorithms.

  12. Injection-seeded tunable mid-infrared pulses generated by difference frequency mixing

    NASA Astrophysics Data System (ADS)

    Miyamoto, Yuki; Hara, Hideaki; Masuda, Takahiko; Hiraki, Takahiro; Sasao, Noboru; Uetake, Satoshi

    2017-03-01

    We report on the generation of nanosecond mid-infrared pulses having frequency tunability, a narrow linewidth, and a high pulse energy. These pulses are obtained by frequency mixing between injection-seeded near-infrared pulses in potassium titanyl arsenate crystals. A continuous-wave external cavity laser diode or a Ti:sapphire ring laser is used as a tunable seeding source for the near-infrared pulses. The typical energy of the generated mid-infrared pulses is in the range of 0.4–1 mJ/pulse. The tuning wavelength ranges from 3142 to 4806 nm. A narrow linewidth of 1.4 GHz and good frequency reproducibility of the mid-infrared pulses are confirmed by observing a rovibrational absorption line of gaseous carbon monoxide at 4587 nm.

  13. Expression of kisspeptin protein in hypothalamus and LH profile of growing female lambs.

    PubMed

    Polkowska, Jolanta; Wójcik-Gładysz, Anna; Chmielewska, Natalia; Wańkowska, Marta

    2017-09-18

    Kisspeptin (kp) is considered to be one of the major regulators of the induction of pubertal events via the activation of the gonadotrophin-releasing hormone-LH system. The aim of the present study was to analyse expression of immunoreactive (ir) kp in the hypothalamic neurons of female lambs from the neonatal to the peripubertal period (5 days to 32 weeks) in relation to the plasma LH pattern using immunohistochemistry and image analysis. Hypothalami were collected from female lambs (n=33) from the infantile, juvenile, prepubertal and peripubertal periods. The population of kp-ir perikarya was detected mainly in the arcuate nucleus and their number increased gradually from 5 to 16 weeks of age and was maintained at a high level up to the peripubertal stage. This was reflected by the significant (P<0.05) gradual increase in the percentage of hypothalamic area occupied by kp-ir neurons and increase in the number of kp-ir perikarya within the arcuate nucleus. The same pattern of kp immunoreactivity was observed in the median eminence. Plasma LH concentration increased from Week 5 to Weeks 12-16 and further increased at Week 32. LH pulse frequency increased from Week 5 to 32 (P<0.05). Thus, changes in kp expression reflected changes in the LH pattern during lamb growth. The data obtained provide evidence about the participation of kp in the mechanisms of ontogenic development of ovine reproductive processes.

  14. LH power modulation experiment on JET

    NASA Astrophysics Data System (ADS)

    Baranov, Y.; Kirov, K.; Goniche, M.; Mailloux, J.; Mayoral, M.-L.; Ongena, J.; Nave, F.

    2009-11-01

    LH power modulation was recently used at JET to quantify experimentally the LH current drive efficiency and power deposition. A new approach was applied for the analysis of the amplitude and phase of electron temperature Te perturbations δTe(kωo) at different harmonics k of the modulation frequency ωo. A solution of the Fokker-Planck equation combined with heat transport modelling was used to study the dependence of the ratio of the perturbation of different harmonics k and n, δTe(kωo)/δTe(nωo), and the phase shift of the harmonics δφ(kωo) on the plasma parameters and electron distribution function plateau width, which is directly connected to the current drive efficiency. The results of the modelling were compared with the experimental data to estimate the current drive efficiency. In addition, LH power deposition profiles were deduced from the radial dependence of δφ(ωo). The maximum of the LH power deposition becomes more peripheral and with a reduced current drive efficiency at higher densities. In H-Mode plasmas, at pedestal densities above the LH accessibility limit, a large fraction of the power is absorbed beyond the separatrix. Finally, the experimental power deposition profiles are more peripheral than the calculated ones obtained from combined ray tracing and Fokker-Planck Plank modelling. The experimental results indicate that the LH power spectrum in the plasma is modified, with more power in the high N// components.

  15. Brightened single-bubble sonoluminescence by phase-adjusted high-frequency acoustic pulse.

    PubMed

    Ogi, Hirotsugu; Matsuda, Atsushi; Wada, Kayo; Hirao, Masahiko

    2003-05-01

    This paper experimentally and numerically studies the effect of a high-frequency acoustic pulse on brightening single-bubble sonoluminescence (SBSL). A polyvinylidene fluoride point-focusing transducer was driven by a 700-W pulse generator to superimpose the acoustic pulse on the sonoluminescing bubble. The center frequency of the pulse was 10 MHz and the duration was 0.15 micros. The pulse was triggered every 100 cycles of the low-frequency standing wave used to make SBSL. The intensity of SBSL was measured as a function of time lag of superimposed pulse. Only the pulse that arrived at the bubble at the early growing stage could increase the brightness. This trend was confirmed with a numerical calculation based on the Rayleigh-Plesset equation. The increased brightness reached 300% of those of the classical SBSL flashes when the time lag was correctly adjusted.

  16. Brightened single-bubble sonoluminescence by phase-adjusted high-frequency acoustic pulse

    NASA Astrophysics Data System (ADS)

    Ogi, Hirotsugu; Matsuda, Atsushi; Wada, Kayo; Hirao, Masahiko

    2003-05-01

    This paper experimentally and numerically studies the effect of a high-frequency acoustic pulse on brightening single-bubble sonoluminescence (SBSL). A polyvinylidene fluoride point-focusing transducer was driven by a 700-W pulse generator to superimpose the acoustic pulse on the sonoluminescing bubble. The center frequency of the pulse was 10 MHz and the duration was 0.15 μs. The pulse was triggered every 100 cycles of the low-frequency standing wave used to make SBSL. The intensity of SBSL was measured as a function of time lag of superimposed pulse. Only the pulse that arrived at the bubble at the early growing stage could increase the brightness. This trend was confirmed with a numerical calculation based on the Rayleigh-Plesset equation. The increased brightness reached 300% of those of the classical SBSL flashes when the time lag was correctly adjusted.

  17. Propagation of frequency-modulated pulses in active one-dimensional photonic crystals

    SciTech Connect

    Zolotovskii, I O; Korobko, D A; Ostatochnikov, V A

    2015-02-28

    The propagation of frequency-modulated pulses in onedimensional photonic crystals with gain is considered. A correct expression is derived for the delay time of the pulse maximum. This expression takes into account the input pulse characteristics: duration, frequency modulation and spectrum position in the photonic band gap. The analytical results are basically in agreement with the results of numerical simulation. The influence of gain in the photonic-crystal structure is considered. It is shown that the parameters of a transmitted pulse can be controlled by changing the inputpulse frequency modulation. (nonlinear optical phenomena)

  18. Development of a strontium vapor laser with pulse repetition frequency up to 1 MHz

    NASA Astrophysics Data System (ADS)

    Soldatov, A. N.; Yudin, N. A.; Polunin, Yu. P.; Vasilieva, A. V.; Chebotarev, G. D.; Latush, E. L.; Fesenko, A. A.

    2010-09-01

    The problem of obtaining high pulse repetition frequencies in metal vapor lasers is urgent from the viewpoint of laser application to various technologies, increase of productivity of industrial laser systems, study of transient processes, etc. In addition, the high pulse repetition frequency provides large average laser radiation power in spite of a rather low energy extracted from a single lasing pulse. In this work, the possibility of increasing the pulse repetition frequency of a laser on self-terminated strontium ion transitions was investigated. The double pulse method was used to demonstrate experimentally that a pulse repetition frequency of ~1 MHz could be achieved at wavelengths of 1.03 and 1.09 μm of the strontium vapor laser. To explain the results obtained, the kinetics of the active medium was modeled using the self-consistent mathematical model of a He- Sr+ laser.

  19. The effect of high-frequency electric pulses on tumor blood flow in vivo.

    PubMed

    Raeisi, E; Firoozabadi, S M P; Hajizadeh, S; Rajabi, H; Hassan, Z M

    2010-07-01

    The aim of this study was to evaluate the effect of a 5-kHz repetition frequency of electroporating electric pulses in comparison to the standard 1-Hz frequency on blood flow of invasive ductal carcinoma tumors in Balb/C mice. Electroporation was performed by the delivery of eight electric pulses of 1,000 V cm(-1) and 100 mus duration at a repetition frequency of 1 Hz or 5 kHz. Blood flow changes in tumors were measured by laser Doppler flowmetry. Monitoring was performed continuously for 10 min before application of the electric pulses as well as immediately after application of the electric pulses for 40 min. The delivery of electric pulses to tumors induced changes in tumor blood flow. The reduction in blood flow started after the stimulation and continued for the 40-min period of observation. There was a significant difference in blood flow changes 3 min after application of the electric pulses at 1-Hz or 5-kHz repetition frequency. However, after 3 min the difference became nonsignificant. The findings showed that the high pulse frequency (5 kHz) had an effect comparable to the 1-Hz frequency on tumor blood flow except at very short times after pulse delivery, when pulses at 5 kHz produced a more intense reduction of blood flow.

  20. Experimental studies of breakdown characteristics in pulse-modulated radio-frequency atmospheric discharge

    NASA Astrophysics Data System (ADS)

    Huo, W. G.; Zhang, X.; Gu, J. L.; Ding, Z. F.

    2016-12-01

    The influences of the pulse off-time on the breakdown voltage of the first pulse and the stable pulse discharge (having repeatedly undergone a process of ignition, maintenance, and extinction) are experimentally investigated in a pulse-modulated radio-frequency atmospheric pressure argon discharge. The experimental results show that the first pulse discharge breakdown voltage decreases, but the stable pulse discharge breakdown voltage increases with increasing the pulse off-time. In a large region of the pulse off-time, the luminescence property of the initial breakdown stage is studied using a high speed camera. The captured images at different pulse off-times demonstrate that the gas breakdown exhibits five key characteristics: single-point random breakdown, multi-point random breakdown, stable uniform breakdown, stable glow mixed with pattern breakdown, and stable nonuniform pattern breakdown. The physical reasons for these results are discussed.

  1. Generation of low-frequency nonlinear currents in plasma by an ultrashort pulse of high-frequency radiation

    SciTech Connect

    Grishkov, V. E.; Uryupin, S. A.

    2015-07-15

    A kinetic theory of low-frequency currents induced in plasma by an ultrashort high-frequency radiation pulse is developed. General expressions for the currents flowing along the propagation direction of the pulse and along the gradient of the field energy density are analyzed both analytically and numerically for pulse durations longer or shorter than or comparable with the electron collision time in plasma. It is demonstrated that the nonlinear current flowing along the gradient of the field energy density can be described correctly only when the modification of the isotropic part of the electron distribution function is taken into account.

  2. Intracavity frequency doubling of {mu}s alexandrite laser pulses

    SciTech Connect

    Brinkmann, R.; Schoof, K.

    1994-12-31

    Intracavity second harmonic generation (SHG) with a three mirror folded cavity configuration was investigated with a flashlamp pumped, Q-switched Alexandrite laser. The authors therefore used different nonlinear optical crystals to convert the fundamental 750 nm radiation into the near UV spectral ,range (3 75 nm). The laser pulses were stretched into the {mu}s time domain by an electronic feedback system regulating the losses of the resonator. They investigated the conversion efficiency for different pulse lengths as well as the effect of pulse-lengthening due to the nonlinearity of the intracavity losses introduced by the optical crystal used. Working with BBO-crystals, they were able to achieve a second harmonic output of 25 mJ per pulse at 375 mn with a temporal rectangular pulse of 1 {mu}s in length and a stable nearly gaussian shaped beam profile.

  3. Characterization of Ultrafast Laser Pulses using a Low-dispersion Frequency Resolved Optical Grating Spectrometer

    NASA Astrophysics Data System (ADS)

    Whitelock, Hope; Bishop, Michael; Khosravi, Soroush; Obaid, Razib; Berrah, Nora

    2016-05-01

    A low dispersion frequency-resolved optical gating (FROG) spectrometer was designed to characterize ultrashort (<50 femtosecond) laser pulses from a commercial regenerative amplifier, optical parametric amplifier, and a home-built non-colinear optical parametric amplifier. This instrument splits a laser pulse into two replicas with a 90:10 intensity ratio using a thin pellicle beam-splitter and then recombines the pulses in a birefringent medium. The instrument detects a wavelength-sensitive change in polarization of the weak probe pulse in the presence of the stronger pump pulse inside the birefringent medium. Scanning the time delay between the two pulses and acquiring spectra allows for characterization of the frequency and time content of ultrafast laser pulses, that is needed for interpretation of experimental results obtained from these ultrafast laser systems. Funded by the DoE-BES, Grant No. DE-SC0012376.

  4. Bubble Pulse Cancelation in the Time-Frequency Domain Using Warping Operators

    NASA Astrophysics Data System (ADS)

    Niu, Hai-Qiang; Zhang, Ren-He; Li, Zheng-Lin; Guo, Yong-Gang; He, Li

    2013-08-01

    The received shock waves produced by explosive charges are often polluted by bubble pulses in underwater acoustic experiments. A method based on warping operators is proposed to cancel the bubble pulses in the time-frequency domain. This is applied to the explosive data collected during the Yellow Sea experiment in November 2000. The original received signal is first transformed into a warped signal by warping operators. Then, the warped signal is analyzed in the time-frequency domain. Due to the different features between the shock waves and the bubble pulses in the time-frequency domain for the warped signal, the bubble pulses can be easily filtered out. Furthermore, the shock waves in the original time domain can be retrieved by the inverse warping transformation. The autocorrelation functions and the time-frequency representation show that the bubble pulses can be canceled effectively.

  5. ADRF experiments using near n.pi pulse strings. [Adiabatic Demagnetization due to Radio Frequency pulses

    NASA Technical Reports Server (NTRS)

    Rhim, W. K.; Burum, D. P.; Elleman, D. D.

    1977-01-01

    Adiabatic demagnetization (ADRF) can be achieved in a dipolar coupled nuclear spin system in solids by applying a string of short RF pulses and gradually modulating the pulse amplitudes or pulse angles. This letter reports an adiabatic inverse polarization effect in solids and a rotary spin echo phenomenon observed in liquids when the pulse angle is gradually changed across integral multiples of pi during a string of RF pulses. The RF pulse sequence used is illustrated along with the NMR signal from a CaF2 single crystal as observed between the RF pulses and the rotary spin echo signal observed in liquid C6F6 for n = 2. The observed effects are explained qualitatively on the basis of average Hamiltonian theory.

  6. Effect of frequency-doubling pulse Nd:YAG laser on microbial mutation

    NASA Astrophysics Data System (ADS)

    Zhao, Yansheng; Wang, Luyan; Zheng, Heng; Yin, Hongping; Chen, Xiangdong; Tan, Zheng; Wu, Wutong

    1999-09-01

    We are going to report the mutagenic effect of frequency-doubling pulse Nd:YAG laser (532 nm) on microbe. After irradiation with pulse laser, mutants of abscisic acid producing strains and erythromycin producing strains were obtained, one of which could produce 62.1% and 57% more products than control, respectively. In the study of mutagenization of Spirulina platensis caused by pulse laser, we selected a high photosynthetic strains, with improved productivity of protein and exocellular ploysaccharides of 12% and 246%, respectively. The experimental results indicate that frequency-doubling pulse laser (532 nm) is a potential new type of physical mutagenic factor.

  7. Pulsed blue laser source based on frequency quadrupling of a thulium fiber laser

    NASA Astrophysics Data System (ADS)

    Honea, Eric; Savage-Leuchs, Matthias; Bowers, Mark S.; Yilmaz, Tolga; Mead, Roy

    2013-03-01

    We describe a pulsed blue (485 nm) laser source based on frequency quadrupling a pulsed Tm fiber laser. Up to 1.2 W at 485 nm was generated with an M2 of 1.3. At 10 kHz pulse repetition frequency, the output pulse at 485 nm was 65 ns FWHM resulting in an estimated peak power of 1.8 kW. We anticipate further improvements in power scaling with higher power Tm fiber lasers and improved conversion efficiency to the blue with optimized AR coatings and nonlinear optical crystals.

  8. Effects of pulsed electromagnetic field frequencies on the osteogenic differentiation of human mesenchymal stem cells.

    PubMed

    Luo, Fei; Hou, Tianyong; Zhang, Zehua; Xie, Zhao; Wu, Xuehui; Xu, Jianzhong

    2012-04-01

    The purpose of this study was to evaluate the effect of different frequencies of pulsed electromagnetic fields on the osteogenic differentiation of human mesenchymal stem cells. Third-generation human mesenchymal stem cells were irradiated with different frequencies of pulsed electromagnetic fields, including 5, 25, 50, 75, 100, and 150 Hz, with a field intensity of 1.1 mT, for 30 minutes per day for 21 days. Changes in human mesenchymal stem cell morphology were observed using phase contrast microscopy. Alkaline phosphatase activity and osteocalcin expression were also determined to evaluate human mesenchymal stem cell osteogenic differentiation.Different effects were observed on human mesenchymal stem cell osteoblast induction following exposure to different pulsed electromagnetic field frequencies. Levels of human mesenchymal stem cell differentiation increased when the pulsed electromagnetic field frequency was increased from 5 hz to 50 hz, but the effect was weaker when the pulsed electromagnetic field frequency was increased from 50 Hz to 150 hz. The most significant effect on human mesenchymal stem cell differentiation was observed at of 50 hz.The results of the current study show that pulsed electromagnetic field frequency is an important factor with regard to the induction of human mesenchymal stem cell differentiation. Furthermore, a pulsed electromagnetic field frequency of 50 Hz was the most effective at inducing human mesenchymal stem cell osteoblast differentiation in vitro.

  9. Difference frequency generation of femtosecond mid infrared pulses employing intense Stokes pulses excitation in a photonic crystal fiber.

    PubMed

    Yao, Yuhong; Knox, Wayne H

    2012-11-05

    We demonstrate a novel method of generating milli-watt level mid-IR (MIR) pulses based on difference frequency mixing of the output from a 40 MHz Yb fiber Chirped Pulse Amplifier (CPA) and the intense Stokes pulses generated in a photonic crystal fiber (PCF) with two closely spaced zero dispersion wavelengths (ZDW). By taking advantage of the unique dispersion profile of the fiber, high power narrowband Stokes pulses are selectively generated in the normal dispersion region of the PCF with up to 1.45 nJ of pulse energy. Mixing with 12 nJ of pump pulses at 1035 nm in a type-II AgGaS(2) crystal yields MIR pulses around 5.5 µm wavelength with up to 3 mW of average power and 75 pJ of pulse energy. The reported method can be extended to generation of other MIR wavelengths by selecting PCFs with different second ZDWs or engineering the fiber dispersion profile via longitudinal tapering.

  10. A single-frequency Ho:YLF pulsed laser with frequency stability better than 500 kHz

    NASA Astrophysics Data System (ADS)

    Kucirek, P.; Meissner, A.; Nyga, S.; Mertin, J.; Höfer, M.; Hoffmann, H.-D.

    2017-03-01

    The spectral stability of a previously reported Ho:YLF single frequency pulsed laser oscillator emitting at 2051 nm is drastically improved by utilizing a narrow linewidth Optically Pumped Semiconductor Laser (OPSL) as a seed for the oscillator. The oscillator is pumped by a dedicated gain-switched Tm:YLF laser at 1890 nm. The ramp-and-fire method is employed for generating single frequency emission. The heterodyne technique is used to analyze the spectral properties. The laser is designed to meet a part of the specifications for future airborne or space borne LIDAR detection of CO2. Seeding with a DFB diode and with an OPSL are compared. With OPSL seeding an Allan deviation of the centroid of the spectral distribution of 38 kHz and 517 kHz over 10 seconds and 60 milliseconds of sampling time for single pulses is achieved. The spectral width is approximately 30 MHz. The oscillator emits 2 mJ pulse energy with 50 Hz pulse repetition frequency (PRF) and 20 ns pulse duration. The optical to optical efficiency of the Ho:YLF oscillator is 10 % and the beam quality is diffraction limited. To our knowledge this is the best spectral stability demonstrated to date for a Ho:YLF laser with millijoule pulse energy and nanosecond pulse duration.

  11. Diversified pulse generation from frequency shifted feedback Tm-doped fibre lasers

    PubMed Central

    Chen, He; Chen, Sheng-Ping; Jiang, Zong-Fu; Hou, Jing

    2016-01-01

    Pulsed fibre lasers operating in the eye-safe 2 μm spectral region have numerous potential applications in areas such as remote sensing, medicine, mid-infrared frequency conversion, and free-space communication. Here, for the first time, we demonstrate versatile 2 μm ps-ns pulses generation from Tm-based fibre lasers based on frequency shifted feedback and provide a comprehensive report of their special behaviors. The lasers are featured with elegant construction and the unparalleled capacity of generating versatile pulses. The self-starting mode-locking is initiated by an intra-cavity acousto-optical frequency shifter. Diversified mode-locked pulse dynamics were observed by altering the pump power, intra-cavity polarization state and cavity structure, including as short as 8 ps single pulse sequence, pulse bundle state and up to 12 nJ, 3 ns nanosecond rectangular pulse. A reflective nonlinear optical loop mirror was introduced to successfully shorten the pulses from 24 ps to 8 ps. Beside the mode-locking operation, flexible Q-switching and Q-switched mode-locking operation can also be readily achieved in the same cavity. Up to 78 μJ high energy nanosecond pulse can be generated in this regime. Several intriguing pulse dynamics are characterized and discussed. PMID:27193213

  12. Diversified pulse generation from frequency shifted feedback Tm-doped fibre lasers

    NASA Astrophysics Data System (ADS)

    Chen, He; Chen, Sheng-Ping; Jiang, Zong-Fu; Hou, Jing

    2016-05-01

    Pulsed fibre lasers operating in the eye-safe 2 μm spectral region have numerous potential applications in areas such as remote sensing, medicine, mid-infrared frequency conversion, and free-space communication. Here, for the first time, we demonstrate versatile 2 μm ps-ns pulses generation from Tm-based fibre lasers based on frequency shifted feedback and provide a comprehensive report of their special behaviors. The lasers are featured with elegant construction and the unparalleled capacity of generating versatile pulses. The self-starting mode-locking is initiated by an intra-cavity acousto-optical frequency shifter. Diversified mode-locked pulse dynamics were observed by altering the pump power, intra-cavity polarization state and cavity structure, including as short as 8 ps single pulse sequence, pulse bundle state and up to 12 nJ, 3 ns nanosecond rectangular pulse. A reflective nonlinear optical loop mirror was introduced to successfully shorten the pulses from 24 ps to 8 ps. Beside the mode-locking operation, flexible Q-switching and Q-switched mode-locking operation can also be readily achieved in the same cavity. Up to 78 μJ high energy nanosecond pulse can be generated in this regime. Several intriguing pulse dynamics are characterized and discussed.

  13. Range and Velocity Estimation of Moving Targets Using Multiple Stepped-frequency Pulse Trains

    PubMed Central

    Li, Gang; Meng, Huadong; Xia, Xiang-Gen; Peng, Ying-Ning

    2008-01-01

    Range and velocity estimation of moving targets using conventional stepped-frequency pulse radar may suffer from the range-Doppler coupling and the phase wrapping. To overcome these problems, this paper presents a new radar waveform named multiple stepped-frequency pulse trains and proposes a new algorithm. It is shown that by using multiple stepped-frequency pulse trains and the robust phase unwrapping theorem (RPUT), both of the range-Doppler coupling and the phase wrapping can be robustly resolved, and accordingly, the range and the velocity of a moving target can be accurately estimated. PMID:27879769

  14. Pulsed infrared difference frequency generation in CdGeAs/sub 2/

    DOEpatents

    Piltch, M.S.; Rink, J.P.; Tallman, C.R.

    1975-11-26

    A laser apparatus for generating a line-tunable pulsed infrared difference frequency output is described. The apparatus comprises a CO/sub 2/ laser which produces a first frequency, a CO laser which produces a second frequency, and a mixer for combining the output of the CO/sub 2/ and CO lasers so as to produce a final output comprising a difference frequency from the first and second frequency outputs.

  15. Pulsed infrared difference frequency generation in CdGeAs.sub.2

    DOEpatents

    Piltch, Martin S.; Rink, John P.; Tallman, Charles R.

    1977-03-08

    The disclosure relates to a laser apparatus for generating a line-tunable pulsed infrared difference frequency output. The apparatus comprises a CO.sub.2 laser which produces a first frequency, a CO laser which produces a second frequency and a mixer for combining the output of the CO.sub.2 and CO lasers so as to produce a final output comprising a difference frequency from the first and second frequency outputs.

  16. Permeabilization of plant tissues by monopolar pulsed electric fields: effect of frequency.

    PubMed

    Asavasanti, Suvaluk; Ristenpart, William; Stroeve, Pieter; Barrett, Diane M

    2011-01-01

    Pulsed electric fields (PEF) nonthermally induce cell membrane permeabilization and thereby improve dehydration and extraction efficiencies in food plant materials. Effects of electrical field strength and number of pulses on plant tissue integrity have been studied extensively. Two previous studies on the effect of pulse frequency, however, did not provide a clear view: one study suggested no effect of frequency, while the other found a greater impact on tissue integrity at lower frequency. This study establishes the effect of pulse frequency on integrity of onion tissues. Changes in electrical characteristics, ion leakage, texture parameters, and percent weight loss were quantified for a wide range of pulse frequencies under conditions of fixed field strength and pulse number. Optical microscopy and viable-cell staining provided direct visualization of effects on individual cells. The key finding is that lower frequencies (f < 1 Hz) cause more damage to tissue integrity than higher frequencies (f = 1 to 5000 Hz). Intriguingly, the optical microscopy observations demonstrate that the speed of intracellular convective motion (that is, cytoplasmic streaming) following PEF application is strongly correlated with PEF frequency. We provide the first in situ visualization of the intracellular consequence of PEF at different frequencies in a plant tissue. We hypothesize that cytoplasmic streaming plays a significant role in moving conductive ionic species from permeabilized cells to the intercellular space between plant cells, making subsequent pulses more efficacious at sufficiently low frequencies. The results suggest that decreasing the pulse frequency in PEF may minimize the number of pulses needed to achieve a desired amount of permeabilization, thus lowering the total energy consumption. Practical Application: PEF cause pores to be formed in plant cell membranes, thereby improve moisture removal and potential extraction of desirable components. This study used in

  17. Advantages of high-frequency Pulse-tube technology and its applications in infrared sensing

    NASA Astrophysics Data System (ADS)

    Arts, R.; Willems, D.; Mullié, J.; Benschop, T.

    2016-05-01

    The low-frequency pulse-tube cryocooler has been a workhorse for large heat lift applications. However, the highfrequency pulse tube has to date not seen the widespread use in tactical infrared applications that Stirling cryocoolers have had, despite significant advantages in terms of exported vibrations and lifetime. Thales Cryogenics has produced large series of high-frequency pulse-tube cryocoolers for non-infrared applications since 2005. However, the use of Thales pulse-tube cryocoolers for infrared sensing has to date largely been limited to high-end space applications. In this paper, the performances of existing available off-the-shelf pulse-tube cryocoolers are examined versus typical tactical infrared requirements. A comparison is made on efficiency, power density, reliability, and cost. An outlook is given on future developments that could bring the pulse-tube into the mainstream for tactical infrared applications.

  18. Experimental studies of the overshoot and undershoot in pulse-modulated radio-frequency atmospheric discharge

    SciTech Connect

    Huo, W. G.; Li, R. M.; Shi, J. J.; Ding, Z. F.

    2016-08-15

    The overshoot and undershoot of the applied voltage on the electrodes, the discharge current, and radio frequency (RF) power were observed at the initial phase of pulse-modulated (PM) RF atmospheric pressure discharges, but factors influencing the overshoot and undershoot have not been fully elucidated. In this paper, the experimental studies were performed to seek the reasons for the overshoot and undershoot. The experimental results show that the overshoot and undershoot are associated with the pulse frequency, the rise time of pulse signal, and the series capacitor C{sub s} in the inversely L-shaped matching network. In the case of a high RF power discharge, these overshoot and undershoot become serious when shortening the rise time of a pulse signal (5 ns) or operating at a moderate pulse frequency (500 Hz or 1 kHz).

  19. Investigation of the input signal frequency effect on the formed pulse of the hydraulic-powered pulse machine

    NASA Astrophysics Data System (ADS)

    Novoseltseva, M. V.; Masson, I. A.

    2016-04-01

    Nowadays, a special emphasis is placed on an output signal curve during the analysis of well drilling machines since these machines should have as high energy efficiency as it is possible. This work proposes factors that have an impact of input signal frequency on the formed pulse that are used to find the most efficient frequency for its further applying in the machine. Results of the conducted experiment are obtained by using a mathematical model that is created in Simulink Matlab.

  20. Measuring ultrashort pulses using frequency-resolved optical gating

    SciTech Connect

    Trebino, R.

    1993-12-01

    The purpose of this program is the development of techniques for the measurement of ultrafast events important in gas-phase combustion chemistry. Specifically, goals of this program include the development of fundamental concepts and spectroscopic techniques that will augment the information currently available with ultrafast laser techniques. Of equal importance is the development of technology for ultrafast spectroscopy. For example, methods for the production and measurement of ultrashort pulses at wavelengths important for these studies is an important goal. Because the specific vibrational motion excited in a molecule depends sensitively on the intensity, I(t), and the phase, {psi}(t), of the ultrashort pulse used to excite the motion, it is critical to measure both of these quantities for an individual pulse. Unfortunately, this has remained an unsolved problem for many years. Fortunately, this year, the authors present a technique that achieves this goal.

  1. Influence of laser pulse frequency on the microstructure of aluminum nitride thin films synthesized by pulsed laser deposition

    NASA Astrophysics Data System (ADS)

    Antonova, K.; Duta, L.; Szekeres, A.; Stan, G. E.; Mihailescu, I. N.; Anastasescu, M.; Stroescu, H.; Gartner, M.

    2017-02-01

    Aluminum Nitride (AlN) thin films were synthesized on Si (100) wafers at 450 °C by pulsed laser deposition. A polycrystalline AlN target was multipulsed irradiated in a nitrogen ambient, at different laser pulse repetition rate. Grazing Incidence X-Ray Diffraction and Atomic Force Microscopy analyses evidenced nanocrystallites with a hexagonal lattice in the amorphous AlN matrix. The thickness and optical constants of the layers were determined by infrared spectroscopic ellipsometry. The optical properties were studied by Fourier Transform Infrared reflectance spectroscopy in polarised oblique incidence radiation. Berreman effect was observed around the longitudinal phonon modes of the crystalline AlN component. Angular dependence of the A1LO mode frequency was analysed and connected to the orientation of the particles' optical axis to the substrate surface normal. The role of the laser pulse frequency on the layers' properties is discussed on this basis.

  2. Measuring the Frequency of Light with Femtosecond Laser Pulses

    NASA Astrophysics Data System (ADS)

    Udem, Thomas

    2001-04-01

    We have shown that the modes of a femtosecond mode-locked laser are distributed uniformly in frequency space and can be used like a ruler to measure large optical frequency differences. To measure absolute optical frequencies we created a frequency comb that contained a full optical octave to measure the gap that is spanned by this octave. Unlike the complex harmonic frequency chains used in the past this new approach uses only one laser sources and is nevertheless capable of measuring almost any optical frequency with the same set up. We applied the new technique to determine the absolute frequencies of the cesium D1, of several components in Iodine around 563 THz, a sharp "clock" transition in a single trapped Indium ion and the hydrogen 1S-2S transition. We also tested its performance by comparing two similar set-ups.

  3. Interaction between pulsed discharge and radio frequency discharge burst at atmospheric pressure

    SciTech Connect

    Zhang, Jie; Guo, Ying; Shi, Yuncheng; Zhang, Jing; Shi, J. J.

    2015-08-15

    The atmospheric pressure glow discharges (APGD) with dual excitations in terms of pulsed voltage and pulse-modulation radio frequency (rf) power are studied experimentally between two parallel plates electrodes. Pulse-modulation applied in rf APGD temporally separates the discharge into repetitive discharge bursts, between which the high voltage pulses are introduced to ignite sub-microsecond pulsed discharge. The discharge characteristics and spatio-temporal evolution are investigated by means of current voltage characteristics and time resolved imaging, which suggests that the introduced pulsed discharge assists the ignition of rf discharge burst and reduces the maintain voltage of rf discharge burst. Furtherly, the time instant of pulsed discharge between rf discharge bursts is manipulated to study the ignition dynamics of rf discharge burst.

  4. Effect of laser pulse repetition frequency on the optical breakdown threshold of quartz glass

    SciTech Connect

    Kononenko, T V; Konov, V I; Schöneseiffen, S; Dausinger, F

    2013-08-31

    The thresholds of optical breakdown in the volume of quartz glass were measured in relation to the number of pulses under irradiation by ultrashort laser pulses with different pulse repetition frequencies (1 – 400 kHz). Increasing this frequency from 10 to 400 kHz was found to substantially lower the breakdown threshold for 500-fs long pulses (at a wavelength of 1030 nm) and to lower to a smaller degree for 5-ps long pulses (515 nm). A strong frequency dependence of the breakdown threshold is observed under the same conditions as a manifold decrease of the breakdown threshold with increase in the number of pulses in a pulse train. The dependence of the optical breakdown on the number of pulses is attributable to the accumulation of point defects under multiple subthreshold irradiation, which affects the mechanism of collisional ionisation. In this case, the frequency dependence of the breakdown threshold of quartz glass is determined by the engagement of shortlived defects in the ionisation mechanism. (interaction of laser radiation with matter)

  5. A single-frequency double-pulse Ho:YLF laser for CO2-lidar

    NASA Astrophysics Data System (ADS)

    Kucirek, P.; Meissner, A.; Eiselt, P.; Höfer, M.; Hoffmann, D.

    2016-03-01

    A single-frequency q-switched Ho:YLF laser oscillator with a bow-tie ring resonator, specifically designed for highspectral stability, is reported. It is pumped with a dedicated Tm:YLF laser at 1.9 μm. The ramp-and-fire method with a DFB-diode laser as a reference is employed for generating single-frequency emission at 2051 nm. The laser is tested with different operating modes, including cw-pumping at different pulse repetition frequencies and gain-switched pumping. The standard deviation of the emission wavelength of the laser pulses is measured with the heterodyne technique at the different operating modes. Its dependence on the single-pass gain in the crystal and on the cavity finesse is investigated. At specific operating points the spectral stability of the laser pulses is 1.5 MHz (rms over 10 s). Under gain-switched pumping with 20% duty cycle and 2 W of average pump power, stable single-frequency pulse pairs with a temporal separation of 580 μs are produced at a repetition rate of 50 Hz. The measured pulse energy is 2 mJ (<2 % rms error on the pulse energy over 10 s) and the measured pulse duration is approx. 20 ns for each of the two pulses in the burst.

  6. Effect of noise on Frequency-Resolved Optical Gating measurements of ultrashort pulses

    SciTech Connect

    Fittinghoff, D.N.; DeLong, K.W.; Ladera, C.L.; Trebino, R.

    1995-02-01

    We study the effects of noise in Frequency-Resolved Optical Gating measurements of ultrashort pulses. We quantify the measurement accuracy in the presence of additive, muliplicative, and quantization noise, and discuss filtering and pre-processing of the data.

  7. Frequency-chirp rates of harmonics driven by a few-cycle pulse

    SciTech Connect

    Murakami, M.; Mauritsson, J.; Gaarde, M.B.

    2005-08-15

    We present numerical calculations of the time-frequency characteristics of cutoff harmonics generated by few-cycle laser pulses. We find that for driving pulses as short as three optical cycles, the adiabatic prediction for the harmonic chirp rate is very accurate. This negative chirp is so large that the resulting bandwidth causes substantial overlap between neighboring harmonics, and the harmonic phase therefore appears to not vary in time or frequency. By adding a compensating positive chirp to the driving pulse, which reduces the harmonic bandwidth and allows for the appearance of the negative chirp, we can measure the harmonic chirp rates. We also find that the positive chirp on the driving pulse causes the harmonics to shift down in frequency. We show that this counterintuitive result is caused by the change in the strong field continuum dynamics introduced by the variation of the driving frequency with time.

  8. INTERACTION OF LASER RADIATION WITH MATTER. LASER PLASMA: Collision frequency shift of a short electromagnetic pulse

    NASA Astrophysics Data System (ADS)

    Chegotov, M. V.

    2004-03-01

    The frequency shift of a short electromagnetic pulse interaction with a plasma-like medium is discovered and studied. The shift is caused by elastic collisions of free electrons with ions or neutral particles.

  9. Direct Visualization of Exciton Reequilibration in the LH1 and LH2 Complexes of Rhodobacter sphaeroides by Multipulse Spectroscopy

    SciTech Connect

    Stuart, Thomas A. Cohen; Vengris, Mikas; Novoderezhkin, Vladimir I.; Cogdell, Richard J.; Hunter, C. Neil; van Grondelle, Rienk

    2011-01-01

    The dynamics of the excited states of the light-harvesting complexes LH1 and LH2 of Rhodobacter sphaeroides are governed, mainly, by the excitonic nature of these ring-systems. In a pump-dump-probe experiment, the first pulse promotes LH1 or LH2 to its excited state and the second pulse dumps a portion of the excited state. By selective dumping, we can disentangle the dynamics normally hidden in the excited-state manifold. We find that by using this multiple-excitation technique we can visualize a 400-fs reequilibration reflecting relaxation between the two lowest exciton states that cannot be directly explored by conventional pump-probe. An oscillatory feature is observed within the exciton reequilibration, which is attributed to a coherent motion of a vibrational wavepacket with a period of ~150 fs. Our disordered exciton model allows a quantitative interpretation of the observed reequilibration processes occurring in these antennas.

  10. Phase and Frequency Control of Laser Arrays for Pulse Synthesis

    DTIC Science & Technology

    2015-01-02

    passively mode-locked vertical-external-cavity surface- emitting lasers ( VECSELs ) [5, 6], quantum dot lasers with tapered gain sections [7], and...Ritchie, B. Kunert, B. Heinen, and W. Stolz, Ř.35 kW peak power femtosecond pulse mode-locked VECSEL for supercontinuum generation," Opt. Express 21

  11. Radio frequency treatments for insect disinfestation of dried pulses

    USDA-ARS?s Scientific Manuscript database

    Dried pulses, such as chickpeas, green peas or lentils, are valuable export commodities in the US Pacific Northwest. A major problem in the marketing of these products is infestation by insect pests, which may cause importing countries to require phytosanitary treatments before shipment. Typically...

  12. LH power modulation experiment on JET

    SciTech Connect

    Baranov, Y.; Kirov, K.; Mailloux, J.; Mayoral, M.-L.; Nave, F.; Ongena, J.

    2009-11-26

    LH power modulation was recently used at JET to quantify experimentally the LH current drive efficiency and power deposition. A new approach was applied for the analysis of the amplitude and phase of electron temperature T{sub e} perturbations {delta}T{sub e}(k{omega}{sub o}) at different harmonics k of the modulation frequency {omega}{sub o}. A solution of the Fokker-Planck equation combined with heat transport modelling was used to study the dependence of the ratio of the perturbation of different harmonics k and n, {delta}T{sub e}(k{omega}{sub o})/{delta}T{sub e}(n{omega}{sub o}), and the phase shift of the harmonics {delta}{phi}(k{omega}{sub o}) on the plasma parameters and electron distribution function plateau width, which is directly connected to the current drive efficiency. The results of the modelling were compared with the experimental data to estimate the current drive efficiency. In addition, LH power deposition profiles were deduced from the radial dependence of {delta}{phi}({omega}{sub o}). The maximum of the LH power deposition becomes more peripheral and with a reduced current drive efficiency at higher densities. In H-Mode plasmas, at pedestal densities above the LH accessibility limit, a large fraction of the power is absorbed beyond the separatrix. Finally, the experimental power deposition profiles are more peripheral than the calculated ones obtained from combined ray tracing and Fokker-Planck Plank modelling. The experimental results indicate that the LH power spectrum in the plasma is modified, with more power in the high N// components.

  13. Electron energy enhancement by frequency chirped axicon Gaussian laser pulse in vacuum

    NASA Astrophysics Data System (ADS)

    Rajput, Jyoti; Kant, Niti; Singh, Arvinder

    2017-07-01

    Electron acceleration by a frequency - chirped lowest axicon Gaussian laser pulse in vacuum is studied. Terawatt RP laser can be focussed down by an axicon optical element, which produces a very strong longitudinal electric field. A linear frequency chirp increases the time duration of interaction of laser pulse with electron and hence, influences electron motion significantly. It is noticed that an electron with initial energy of few MeV, accelerates upto GeV energy under optimized laser parameters. Significant higher energy gain is observed with intense chirped laser pulse in vacuum.

  14. High pulse repetition frequency fiber-coupled laser-diode module

    NASA Astrophysics Data System (ADS)

    Shi, Guangyuan; Li, Song; Huang, Ke; Zheng, Guoxing

    2016-12-01

    A practical and simple approach of achieving a high pulse repetition frequency fiber-coupled laser-diode device is demonstrated both by experiment and TRACEPRO software simulation, which is obtained by beam collimating, spatial beam combining, and polarization beam combining based on multiple cycle-emitting pulsed laser-diode emitters. Using this method, fiber-coupled laser-diode module output pulse repetition frequency from the multimode fiber with 200-μm core diameter and 0.22 numerical aperture can reach 300 kHz, and the coupling efficiency is beyond 72%. This technique has superiors of great flexibility, low cost, and high reliability for wide applications.

  15. Osteoblast behavior on polytetrafluoroethylene modified by long pulse, high frequency oxygen plasma immersion ion implantation.

    PubMed

    Wang, Huaiyu; Kwok, Dixon T K; Wang, Wei; Wu, Zhengwei; Tong, Liping; Zhang, Yumei; Chu, Paul K

    2010-01-01

    Polytetrafluoroethylene (PTFE) is a commonly used medical polymer due to its biological stability and other attractive properties such as high hardness and wear resistance. However, the low surface energy and lack of functional groups to interact with the cellular environment have severely limited its applications in bone or cartilage replacements. Plasma immersion ion implantation (PIII) is a proven effective surface modification technique. However, when conducted on polymeric substrates, conventional PIII experiments typically employ a low pulsing frequency and short pulse duration in order to avoid sample overheating, charging, and plasma sheath extension. In this paper, a long pulse, high frequency O(2) PIII process is described to modify PTFE substrates by implementing a shielded grid in the PIII equipment without these aforementioned adverse effects. X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), and contact angle measurements are carried out to reveal the surface effects of PTFE after long pulse, high frequency O(2) PIII and the results are compared to those obtained from conventional short pulse, low frequency O(2) PIII, O(2) plasma immersion, and the untreated control samples. Our results show that less oxygen-containing, rougher, and more hydrophobic surfaces are produced on PTFE after long pulse, high frequency O(2) PIII compared to the other 2 treatments. Cell viability assay, ALP activity test, and real-time PCR analysis are also performed to investigate the osteoblast behavior. It is clear that all 3 surface modification techniques promote osteoblast adhesion and proliferation on the PTFE substrates. Improvements on the ALP, OPN, and ON expression of the seeded osteoblasts are also obvious. However, among these treatments, only long pulse, high frequency O(2) PIII can promote the OCN expression of osteoblasts when the incubation time is 12 days. Our data unequivocally disclose that the long pulse, high frequency O(2) PIII

  16. Multiple-Frequency Ultrasonic Pulse-Echo Display System.

    DTIC Science & Technology

    1982-09-28

    provides oscilloscope sync . The DELAY pulse’s rising edge coincides with the first waveform sample; the falling edge comes at a time approximately...TRIGGER output as sync for oscilloscope, monitor DELAY output. Set time/div. of scope to 0.5 us/dIv. Using an insulated adjustment tool, set the Venier...must be adjusted out sap - INPUTS rately from the sample hold. This is most easily done by using the Input Voltage Range ...... ... y=0 min gain

  17. Characterization of arbitrary femtosecond pulses using frequency-resolved optical gating

    SciTech Connect

    Kane, D.J. ); Trebino, R. )

    1993-02-01

    The authors introduce a new technique, which they call frequency-resolved optical gating (FROG), for characterizing and displaying arbitrary femtosecond pulses. The method is simple, general, broad-band, and does not require a reference pulse. Using virtually any instantaneous nonlinear-optical effect, FROG involves measuring the spectrum of the signal pulse as a function of the delay between two input pulses. The resulting trace of intensity versus frequency and delay is related to the pulse's spectrogram, a visually intuitive transform containing both time and frequency information. They prove, using phase retrieval concepts, that the FROG trace yields the full intensity l(t) and phase [var phi](t) of an arbitrary ultrashort pulse with no physically significant ambiguities. They argue, in analogy with acoustics problems, that the FROG trace is in many ways as useful a representation of the pulse as the field itself. FROG appears to have temporal resolution limited only by the response of the nonlinear medium. They demonstrate the method using self-diffraction via the electronic Kerr effect in BK-7 glass and few [mu]J, 620 nm, linearly chirped, [approximately]200 fs pulses.

  18. Intra-pulse Raman frequency shift versus conventional Stokes generation of diode laser pulses in optical fibers.

    PubMed

    Kuzin, Evgeny; Mendoza-Vazquez, Sergio; Gutierrez-Gutierrez, Jaime; Ibarra-Escamilla, Baldemar; Haus, Joseph; Rojas-Laguna, Roberto

    2005-05-02

    We report experimental observations of stimulated Raman scattering in a standard fiber using a directly modulated DFB semiconductor laser amplified by two erbium-doped fibers. The laser pulse width was variably controlled on a nanosecond-scale; the laser emission was separated into two distinct regimes: an initial transient peak regime, followed by a quasi steady-state plateau regime. The transient leading part of the pump pulse containing fast amplitude modulation generated a broadband Raman-induced spectral shift through the modulation instability and subsequent intra-pulse Raman frequency shift. The plateau regime amplified the conventional Stokes shifted emission expected from the peaks of the gain distribution. The output signal spectrum at the end of a 9.13 km length of fiber for the transient part extends from 1550 nm to 1700 nm for a pump pulse peak power of 65 W. We found that the Raman-induced spectral shift is measurable about 8 W for every fiber length examined, 0.6 km, 4.46 km, and 9.13 km. All spectral components of the broadband scattering appear to be generated in the initial kilometer of the fiber span. The Stokes shifted light generation threshold was higher than the threshold for the intra-pulse Raman-induced broadened spectra. This fact enables the nonlinear spectral filtering of pulses from directly modulated semiconductor lasers.

  19. Intra-pulse Raman frequency shift versus conventional Stokes generation of diode laser pulses in optical fibers

    NASA Astrophysics Data System (ADS)

    Kuzin, Evgeny A.; Mendoza-Vazquez, Sergio; Gutierrez-Gutierrez, Jaime; Ibarra-Escamilla, Baldemar; Haus, Joseph W.; Rojas-Laguna, Roberto

    2005-05-01

    We report experimental observations of stimulated Raman scattering in a standard fiber using a directly modulated DFB semiconductor laser amplified by two erbium-doped fibers. The laser pulse width was variably controlled on a nanosecond-scale; the laser emission was separated into two distinct regimes: an initial transient peak regime, followed by a quasi steady-state plateau regime. The transient leading part of the pump pulse containing fast amplitude modulation generated a broadband Raman-induced spectral shift through the modulation instability and subsequent intra-pulse Raman frequency shift. The plateau regime amplified the conventional Stokes shifted emission expected from the peaks of the gain distribution. The output signal spectrum at the end of a 9.13 km length of fiber for the transient part extends from 1550 nm to 1700 nm for a pump pulse peak power of 65 W. We found that the Raman-induced spectral shift is measurable about 8 W for every fiber length examined, 0.6 km, 4.46 km, and 9.13 km. All spectral components of the broadband scattering appear to be generated in the initial kilometer of the fiber span. The Stokes shifted light generation threshold was higher than the threshold for the intra-pulse Raman-induced broadened spectra. This fact enables the nonlinear spectral filtering of pulses from directly modulated semiconductor lasers.

  20. Molecular detrapping and band narrowing with high frequency modulation of pulsed field electrophoresis.

    PubMed Central

    Turmel, C; Brassard, E; Slater, G W; Noolandi, J

    1990-01-01

    In high electric fields, megabase DNA fragments are found to be trapped, i.e. to enter or migrate in the gel only very slowly, if at all, leading to very broad electrophoretic bands and loss of separation. As a consequence, low electric fields are usually used to separate these molecules by pulsed field electrophoretic methods. We report here that high-frequency pulses eliminate the molecular trapping found in continuous fields. When high frequency pulses are used to modulate the longer pulses used in pulsed field electrophoresis, narrower bands result, and higher fields can be used. We suggest that this is due to effects that occur on the length scale of a single pore. Images PMID:2408015

  1. Multi-delay, phase coherent pulse pair generation for precision Ramsey-frequency comb spectroscopy.

    PubMed

    Morgenweg, J; Eikema, K S E

    2013-03-11

    We demonstrate the generation of phase-stable mJ-pulse pairs at programmable inter-pulse delays up to hundreds of nanoseconds. A detailed investigation of potential sources for phase shifts during the parametric amplification of the selected pulses from a Ti:Sapphire frequency comb is presented, both numerically and experimentally. It is shown that within the statistical error of the phase measurement of 10 mrad, there is no dependence of the differential phase shift over the investigated inter-pulse delay range of more than 300 ns. In combination with nonlinear upconversion of the amplified pulses, the presented system will potentially enable short wavelength (<100 nm), multi-transition Ramsey-frequency comb spectroscopy at the kHz-level.

  2. Phase retrieval and time-frequency methods in the measurement of ultrashort laser pulses

    SciTech Connect

    DeLong, K.W.; Fittinghoff, D.N.; Ladera, C.L.; Trebino, R.

    1995-02-01

    Recently several techniques have become available to measure the time- (or frequency-) dependent intensity and phase of ultrashort laser pulses. One of these, Frequency-Resolved Optical Gating (FROG), is rigorous and has achieved single-laser-shot operation. FROG combines the concepts of time-frequency analysis in the form of spectrogram generation (in order to create a two-dimensional problem), and uses a phase-retrieval-based algorithm to invert the experimental data to yield the intensity and phase of the laboratory laser pulse. In FROG it is easy to generate a spectrogram of the unknown signal, and inversion of the spectrogram to recover the signal is the main goal. Because the temporal width of a femtosecond laser pulse is much shorter than anything achievable by electronics, FROG uses the pulse to measure itself. In FROG, the laser pulse is split into two replicas of itself by a partially reflecting beamsplitter, and the two replicas interact with each other in a medium with an instantaneous nonlinear-optical response. This interaction generates a signal field that is then frequency-resolved using a spectrometer. The spectrum of the signal field is measured for all relevant values of the temporal delay between the two pulses. Here, the authors employ FROG and FROG related techniques to measure the time-dependent intensity and phase of an ultrashort laser pulse.

  3. Contribution for Iron Vapor and Radiation Distribution Affected by Current Frequency of Pulsed Arc

    NASA Astrophysics Data System (ADS)

    Shimokura, Takuya; Mori, Yusuke; Iwao, Toru; Yumoto, Motoshige

    Pulsed GTA welding has been used for improvement of stability, weld speed, and heat input control. However, the temperature and radiation power of the pulsed arc have not been elucidated. Furthermore, arc contamination by metal vapor changes the arc characteristics, e.g. by increasing radiation power. In this case, the metal vapor in pulsed GTA welding changes the distribution of temperature and radiation power as a function of time. This paper presents the relation between metal vapor and radiation power at different pulse frequencies. We calculate the Fe vapor distribution of the pulsed current. Results show that the Fe vapor is transported at fast arc velocity during the peak current period. During the base current period, the Fe vapor concentration is low and distribution is diffuse. The transition of Fe vapor distribution does not follow the pulsed current; the radiation power density distribution differs for high frequencies and low frequencies. In addition, the Fe vapor and radiation distribution are affected by the pulsed arc current frequency.

  4. 'Carriers of variant luteinizing hormone (V-LH) among 1593 Baltic men have significantly higher serum LH'.

    PubMed

    Punab, A M; Grigorova, M; Punab, M; Adler, M; Kuura, T; Poolamets, O; Vihljajev, V; Žilaitienė, B; Erenpreiss, J; Matulevičius, V; Laan, M

    2015-05-01

    Luteinizing hormone (LH) is a pituitary heterodimeric glycoprotein essential in male and female reproduction. Its functional polymorphic variant (V-LH) is determined by two missense mutations (rs1800447, A/G, Trp8Arg; rs34349826, A/G, Ile15Thr) in the LH β-subunit encoding gene (LHB; 19q13.3; 1111 bp; 3 exons). Among women, V-LH has been associated with higher circulating LH and reduced fertility, but the knowledge of its effect on male reproductive parameters has been inconclusive. The objective of this study was to assess the effect of V-LH on hormonal, seminal and testicular parameters in the Baltic young men cohort (n = 986; age: 20.1 ± 2.1 years) and Estonian idiopathic infertility patients (n = 607; 35.1 ± 5.9 years). V-LH was detected by genotyping of the underlying DNA polymorphisms using PCR-RFLP combined with resequencing of a random subset of subjects. Genetic associations were tested using linear regression under additive model and results were combined in meta-analysis. No significant difference was detected between young men and infertility patients for the V-LH allele frequency (11.0 vs. 9.3%, respectively). V-LH was associated with higher serum LH in both, the young men cohort (p = 0.022, allelic effect = 0.26 IU/L) and the idiopathic infertility group (p = 0.008, effect = 0.59 IU/L). In meta-analysis, the statistical significance was enhanced (p = 0.0007, resistant to Bonferroni correction for multiple testing; effect = 0.33 IU/L). The detected significant association of V-LH with increased serum LH remained unchanged after additional adjustment for the SNPs previously demonstrated to affect LH levels (FSHB -211G/T, FSHR Asn680Ser, FSHR -29A/G). Additionally, a suggestive trend for association with reduced testicular volume was observed among young men, and with lower serum FSH among infertility patients. The V-LH carrier status did not affect sperm parameters and other circulating reproductive hormones. For the first time, we show a conclusive

  5. Numerical investigation of pulse-modulated atmospheric radio frequency discharges in helium under different duty cycles

    SciTech Connect

    Sun Jizhong; Ding Zhengfen; Li Xuechun; Wang Dezhen; Wang Qi

    2011-12-15

    Experiments observed that the pulse duty cycle has effects on the plasma homogeneity in pulse-modulated radio frequency (rf) discharges. In this paper, pulse-modulated rf (13.56 MHz) helium discharges are theoretically investigated using a two dimensional fluid model. With the pulse period being fixed to 15 {mu}s, it is found that when the pulse-on duration is over 4 {mu}s, i.e., the duty cycle is larger than approximately 27%, the discharge transits from an inhomogeneous to a homogeneous mode in every specific part of each pulse cycle under currently-used simulation parameters. More quantitative analysis shows that the discharge becomes more homogeneous as the duty cycle is increased but does not reach complete homogeneity. Possible reasons for the homogeneity improvement are discussed.

  6. Overview of LH operation at JET

    NASA Astrophysics Data System (ADS)

    Kirov, K. K.; Ekedahl, A.; Bernardo, J.; Goniche, M.; Mailloux, J.; Nave, M. F. F.

    2015-12-01

    In this report key aspects of Lower Hybrid Current Drive (LHCD) operation at JET are presented. Amplitude and broadening of the Radio Frequency (RF) spectrum at about 3.7GHz and the frequency shift of the lower sideband were analyzed by means of new diagnostic utilizing RF spectra measurements. Dependencies on plasma density, LH power and the toroidal magnetic field were studied. Plasma rotation profiles with and without LH power were investigated. Power deposition and Current Drive (CD) profiles were assessed by means of a new Ray Tracing / Fokker Planck (RT/FP) code. Significant progress in a number of technological issues including the new supplementary arc protection system based on a visible camera imaging system and operation of the system with waveguides filled with N2 instead of greenhouse SF6 gas was achieved.

  7. Comparison of ultrashort-pulse frequency-resolved-optical-gating traces for three common beam geometries

    SciTech Connect

    DeLong, K.W.; Trebino, R. ); Kane, D.J. )

    1994-09-01

    We recently introduced frequency-resolved optical gating (FROG), a technique for measuring the intensity and phase of an individual, arbitrary, ultrashort laser pulse. FROG can use almost any instantaneous optical nonlinearity, with the most common geometries being polarization gate, self-diffraction, and second-harmonic generation. The experimentally generated FROG trace is intuitive, visually appealing, and can yield quantitative information about the pulse parameters (such as temporal and spectral width and chirp). However, the qualitative and the quantitative features of the FROG trace depend strongly on the geometry used. We compare the FROG traces for several common ultrashort pulses for these three common geometries and, where possible, develop scaling rules that allow one to obtain quantitative information about the pulse directly from the experimental FROG trace. We illuminate the important features of the various FROG traces for transform-limited, linearly chirped, self-phase modulated, and nonlinearly chirped pulses, pulses with simultaneous linear chirp and self-phase modulation, and pulses with simultaneous linear chirp and cubic phase distortion, as well as double pulses, pulses with phase jumps, and pulses with complex intensity and phase substructure.

  8. Designing Adiabatic Radio Frequency Pulses Using the Shinnar–Le Roux Algorithm

    PubMed Central

    Balchandani, Priti; Pauly, John; Spielman, Daniel

    2010-01-01

    Adiabatic pulses are a special class of radio frequency (RF) pulses that may be used to achieve uniform flip angles in the presence of a nonuniform B1 field. In this work, we present a new, systematic method for designing high-bandwidth (BW), low-peak-amplitude adiabatic RF pulses that utilizes the Shinnar–Le Roux (SLR) algorithm for pulse design. Currently, the SLR algorithm is extensively employed to design nonadiabatic pulses for use in magnetic resonance imaging and spectroscopy. We have adapted the SLR algorithm to create RF pulses that also satisfy the adiabatic condition. By overlaying sufficient quadratic phase across the spectral profile before the inverse SLR transform, we generate RF pulses that exhibit the required spectral characteristics and adiabatic behavior. Application of quadratic phase also distributes the RF energy more uniformly, making it possible to obtain the same spectral BW with lower RF peak amplitude. The method enables the pulse designer to specify spectral profile parameters and the degree of quadratic phase before pulse generation. Simulations and phantom experiments demonstrate that RF pulses designed using this new method behave adiabatically. PMID:20806378

  9. Frequency Conversion of Short Optical Pulses in Negatively Spatially Dispersive Metamaterials

    DTIC Science & Technology

    2015-10-22

    Short Optical Pulses inNegatively Spatially Dispersive Metamaterials We show that particular spatial distributions of nanoscopic plasmonic building...distributions of nanoscopic plasmonic building blocks in metamaterials may enable extraordinary nonlinear-optical frequency-shifted reflectivity and...particular spatial distributions of nanoscopic plasmonic building blocks in metamaterials may enable extraordinary nonlinear-optical frequency-shifted

  10. System for generating pluralities of optical pulses with predetermined frequencies in a temporally and spatially overlapped relationship

    DOEpatents

    Meyerhofer, D.D.; Schmid, A.W.; Chuang, Y.

    1992-03-10

    Ultrashort (pico second and shorter) laser pulses having components of different frequency which are overlapped coherently in space and with a predetermined constant relationship in time, are generated and may be used in applications where plural spectrally separate, time-synchronized pulses are needed as in wave-length resolved spectroscopy and spectral pump probe measurements for characterization of materials. A Chirped Pulse Amplifier (CPA), such as a regenerative amplifier, which provides amplified, high intensity pulses at the output thereof which have the same spatial intensity profile, is used to process a series of chirped pulses, each with a different central frequency (the desired frequencies contained in the output pulses). Each series of chirped pulses is obtained from a single chirped pulse by spectral windowing with a mask in a dispersive expansion stage ahead of the laser amplifier. The laser amplifier amplifies the pulses and provides output pulses with like spatial and temporal profiles. A compression stage then compresses the amplified pulses. All the individual pulses of different frequency, which originated in each single chirped pulse, are compressed and thereby coherently overlapped in space and time. The compressed pulses may be used for the foregoing purposes and other purposes wherien pulses having a plurality of discrete frequency components are required. 4 figs.

  11. System for generating pluralities of optical pulses with predetermined frequencies in a temporally and spatially overlapped relationship

    DOEpatents

    Meyerhofer, David D.; Schmid, Ansgar W.; Chuang, Yung-ho

    1992-01-01

    Ultra short (pico second and shorter) laser pulses having components of different frequency which are overlapped coherently in space and with a predetermined constant relationship in time, are generated and may be used in applications where plural spectrally separate, time-synchronized pulses are needed as in wave-length resolved spectroscopy and spectral pump probe measurements for characterization of materials. A Chirped Pulse Amplifier (CPA), such as a regenerative amplifier, which provides amplified, high intensity pulses at the output thereof which have the same spatial intensity profile, is used to process a series of chirped pulses, each with a different central frequency (the desired frequencies contained in the output pulses). Each series of chirped pulses is obtained from a single chirped pulse by spectral windowing with a mask in a dispersive expansion stage ahead of the laser amplifier. The laser amplifier amplifies the pulses and provides output pulses with like spatial and temporal profiles. A compression stage then compresses the amplified pulses. All the individual pulses of different frequency, which originated in each single chirped pulse, are compressed and thereby coherently overlapped in space and time. The compressed pulses may be used for the foregoing purposes and other purposes wherien pulses having a plurality of discrete frequency components are required.

  12. Altered secretion of LH does not explain seasonal effects on early pregnancy in gilts.

    PubMed

    Peltoniemi, O A; Love, R J; Klupiec, C; Revell, D K; Evans, G

    1997-12-05

    This work was undertaken to study the effects of energy intake and gut fill on LH secretion in the early pregnant gilt to investigate the role of the hypothalamo-pituitary-gonadal axis in the seasonal disruption of pregnancy. Four groups of mated gilts (N = 23 in total) were individually housed and fed four different energy levels (23, 46, 47 and 55 megajoules digestible energy per day, MJ DE day-1) for two weeks after mating during the season identified as a period of increased rate of early pregnancy failures from January till April (summer-autumn). The energy content of base feed (13 MJ kg-1) was increased by means of adding a fat supplement (soybean oil) to the feed of two groups of gilts, while the other two groups were given different levels of the basic feed. The groups gained weight and backfat according to energy intake levels during the two-week period. Frequent blood samples (15-min interval) collected on day 14 revealed a significant treatment effect on LH pulse amplitude: the group on the highest energy intake level (55 MJ DE day-1) had higher LH pulse amplitude compared with the other groups (1.01 +/- 0.04, 0.74 +/- 0.04, 0.72 +/- 0.08 and 0.66 +/- 0.05 ng ml-1 in the descending order of energy intake, P < 0.01). There was no effect of energy intake on LH pulse frequency, mean level, area under the curve or mean nadir (P > 0.10). Plasma insulin concentrations tended to increase (P < 0.08) in each group with time after feeding, but no significant differences between the treatment groups were found. Plasma free fatty acid (FFA) concentrations were decreased 1 h after feeding (P < 0.05) in all but the group on 55 MJ DE day-1. This group also had higher postprandial FFA concentrations in comparison with other groups (P < 0.05). In conclusion, these results show that energy density of feed and energy intake have little effect on LH secretion in the early pregnant gilt. Protective effect of high feeding level against seasonal disruption of pregnancy appears

  13. Nonlinear propagation acoustics of dual-frequency wide-band excitation pulses in a focused ultrasound system.

    PubMed

    Måsøy, Svein-Erik; Standal, Øyvind; Deibele, Jochen M; Näsholm, Sven Peter; Angelsen, Bjørn; Johansen, Tonni F; Tangen, Thor Andreas; Hansen, Rune

    2010-11-01

    In this article, acoustic propagation effects of dual-frequency wide-band excitation pulses in a focused ultrasound system are demonstrated in vitro. A designed and manufactured dual-frequency band annular array capable of transmitting 0.9/7.5 MHz center frequency wide-band pulses was used for this purpose. The dual-frequency band annular array, has been designed using a bi-layer piezo-electric stack. Water tank measurements demonstrate the function of the array by activating the low- and high-frequency layers individually and simultaneously. The results show that the array works as intended. Activating the low- and high-frequency layers individually, results in less than -50 dB signal level from the high- and low-frequency layers respectively. Activating both layers simultaneously, produce a well defined dual-frequency pulse. The presence of the low-frequency pulse leads to compression, expansion, and a time delay of the high-frequency pulse. There is a phase shift between the low- and high-frequency pulse as it propagates from the array to the focus. This makes the latter described effects also dependent on the array configuration. By varying the low-frequency pressure, a shift of up to 0.5 MHz in center frequency of a 8.0 MHz transmitted high-frequency pulse is observed at the array focus. The results demonstrate the high propagation complexity of dual-frequency pulses.

  14. Green pulsed lidar-radar emitter based on a multipass frequency-shifting external cavity.

    PubMed

    Zhang, Haiyang; Brunel, Marc; Romanelli, Marco; Vallet, Marc

    2016-04-01

    This paper investigates the radio frequency (RF) up-conversion properties of a frequency-shifting external cavity on a laser beam. We consider an infrared passively Q-switched pulsed laser whose intensity modulation results from the multiple round-trips in the external cavity, which contains a frequency shifter. The output beam undergoes optical second-harmonic generation necessary to reach the green wavelength. We model the pulse train using a rate-equation model to simulate the laser pulses, together with a time-delayed interference calculation taking both the diffraction efficiency and the Gaussian beam propagation into account. The predictions are verified experimentally using a diode-pumped Nd:YAG laser passively Q-switched by Cr4+:YAG whose pulse train makes multiple round-trips in a mode-matched external cavity containing an acousto-optic frequency shifter driven at 85 MHz. Second-harmonic generation is realized in a KTP crystal, yielding RF-modulated pulses at 532 nm with a modulation contrast of almost 100%. RF harmonics up to the 6th order (1.020 GHz) are observed in the green output pulses. Such a RF-modulated green laser may find applications in underwater detection and ranging.

  15. Measurement, comparison, and transformation of dynamic magnetization in pulse field and high-frequency alternating field

    NASA Astrophysics Data System (ADS)

    Kodama, K.

    2015-12-01

    Dynamic magnetizations of selected natural samples (sediments and volcanic rocks) were measured in time domain as well as in frequency domain. The time domain measurements were performed in pulse fields with variable lengths (10 μs to 10 ms) and amplitudes (0.5 mT to 0.7 T). To measure hysteresis parameters for small loops, one cycle of positive and negative pulses with different rate of field variation were generated. In the frequency domain, low-field magnetic susceptibility was measured over the frequency rage (1 kHz to 500 kHz) corresponding to the pulse lengths in the time domain measurements. Results in the time domain were characterized by the transient magnetization-field curves that were broadly comparable to the corresponding portions of the hysteresis loops measured by a quasi-static method using a VSM. The dynamic coercivity that is defined as the intersect with the abscissa in the negative regime increased as the pulse length reduced and the pulse peak increased. In strong pulse fields (> 0.5 T), irrespective of the kinds of samples, the magnetization remained at the end of a pulse and decayed exponentially within a few ms, suggesting rapid magnetic relaxations. In weak pulse fields, no such relaxation was observed except for the sediments rich in superparamagnetic (SP) particles. These field dependencies suggest that the relaxations in the strong fields could be due to the dynamics of the domain walls in the MD particles, while those of the sediments in weak fields may be ascribed to the relaxation of the SP particles. Results in the frequency domain were obtained in terms of the frequency spectrum of the real and imaginary components of complex susceptibility. Comparisons and interpretations of the data in these different domains were made in terms of the distribution of relaxation times. Discussions on the numerical conversion and transformation of these data as well as their rock magnetic applications will be provided.

  16. SONOTECH, INC. FREQUENCY-TUNABLE PULSE COMBUSTION SYSTEM (CELLO PULSE BURNER) - INNOVATIVE TECHNOLOGY EVALUATION REPORT

    EPA Science Inventory

    Sonotech, Inc. (Sonotech) of Atlanta, Georgia, has developed a pulse combustion burner technology that claims to offer benefits when applied in a variety of combustion processes. The technology incorporates a combustor that can be tuned to induce large-amplitude acoustic or soni...

  17. SONOTECH, INC. FREQUENCY-TUNABLE PULSE COMBUSTION SYSTEM (CELLO PULSE BURNER) - INNOVATIVE TECHNOLOGY EVALUATION REPORT

    EPA Science Inventory

    Sonotech, Inc. (Sonotech) of Atlanta, Georgia, has developed a pulse combustion burner technology that claims to offer benefits when applied in a variety of combustion processes. The technology incorporates a combustor that can be tuned to induce large-amplitude acoustic or soni...

  18. Constant frequency pulsed phase-locked loop measuring device

    NASA Astrophysics Data System (ADS)

    Yost, William T.; Kushnick, Peter W.; Cantrell, John H.

    1993-06-01

    A measuring apparatus is presented that uses a fixed frequency oscillator to measure small changes in the phase velocity ultrasonic sound when a sample is exposed to environmental changes such as changes in pressure, temperature, etc. The invention automatically balances electrical phase shifts against the acoustical phase shifts in order to obtain an accurate measurement of electrical phase shifts.

  19. Constant frequency pulsed phase-locked loop measuring device

    NASA Astrophysics Data System (ADS)

    Yost, William T.; Kushnick, Peter W.; Cantrell, John H.

    1991-08-01

    A measuring apparatus is presented that uses a fixed frequency oscillator to measure small changes in the phase velocity ultrasonic sound when a sample is exposed to environmental changes such as changes in pressure, temperature, etc. The invention automatically balances electrical phase shifts against the acoustical phase shifts in order to obtain an accurate measurement of electrical phase shifts.

  20. Constant frequency pulsed phase-locked loop measuring device

    NASA Technical Reports Server (NTRS)

    Yost, William T. (Inventor); Kushnick, Peter W. (Inventor); Cantrell, John H. (Inventor)

    1993-01-01

    A measuring apparatus is presented that uses a fixed frequency oscillator to measure small changes in the phase velocity ultrasonic sound when a sample is exposed to environmental changes such as changes in pressure, temperature, etc. The invention automatically balances electrical phase shifts against the acoustical phase shifts in order to obtain an accurate measurement of electrical phase shifts.

  1. Compact frequency-quadrupled pulsed 1030nm fiber laser

    NASA Astrophysics Data System (ADS)

    McIntosh, Chris; Goldberg, Lew; Cole, Brian; DiLazaro, Tom; Hays, Alan D.

    2016-03-01

    A compact 1030nm fiber laser for ultraviolet generation at 257.5nm is presented. The laser employs a short length of highly-doped, large core (20μm), coiled polarization-maintaining ytterbium-doped double-clad fiber pumped by a wavelength-stabilized 975nm diode. It is passively Q-switched via a Cr4+:YAG saturable absorber and generates 2.4W at 1030nm in a 110μJ pulse train. Lithium triborate (LBO) and beta-barium borate (BBO) are used to achieve 325mW average power at the fourth harmonic. The laser's small form factor, narrow linewidth and modest power consumption are suitable for use in a man-portable ultraviolet Raman explosives detection system.

  2. CMOS in-pixel optical pulse frequency modulator

    NASA Astrophysics Data System (ADS)

    Nel, Nicolaas E.; du Plessis, M.; Joubert, T.-H.

    2016-02-01

    This paper covers the design of a complementary metal oxide semiconductor (CMOS) pixel readout circuit with a built-in frequency conversion feature. The pixel contains a CMOS photo sensor along with all signal-to-frequency conversion circuitry. An 8×8 array of these pixels is also designed. Current imaging arrays often use analog-to-digital conversion (ADC) and digital signal processing (DSP) techniques that are off-chip1. The frequency modulation technique investigated in this paper is preferred over other ADC techniques due to its smaller size, and the possibility of a higher dynamic range. Careful considerations are made regarding the size of the components of the pixel, as various characteristics of CMOS devices are limited by decreasing the scale of the components2. The methodology used was the CMOS design cycle for integrated circuit design. All components of the pixel were designed from first principles to meet necessary requirements of a small pixel size (30×30 μm2) and an output resolution greater than that of an 8-bit ADC. For the photodetector, an n+-p+/p-substrate diode was designed with a parasitic capacitance of 3 fF. The analog front-end stage was designed around a Schmitt trigger circuit. The photo current is integrated on an integration capacitor of 200 fF, which is reset when the Schmitt trigger output voltage exceeds a preset threshold. The circuit schematic and layout were designed using Cadence Virtuoso and the process used was the AMS CMOS 350 nm process using a power supply of 5V. The simulation results were confirmed to comply with specifications, and the layout passed all verification checks. The dynamic range achieved is 58.828 dB per pixel, with the output frequencies ranging from 12.341kHz to 10.783 MHz. It is also confirmed that the output frequency has a linear relationship to the photocurrent generated by the photodiode.

  3. FUNDAMENTAL AREAS OF PHENOMENOLOGY (INCLUDING APPLICATIONS): Conical Double Frequency Emission by Femtosecond Laser Pulses from DKDP

    NASA Astrophysics Data System (ADS)

    Zhang, Xi-Peng; Jiang, Hong-Bing; Tang, Shan-Chun; Gong, Qi-Huang

    2009-07-01

    Conical double frequency emission is investigated by femtosecond laser pulses at a wavelength of 800 nm in a DKDP crystal. It is demonstrated that the sum frequency of incident wave and its scattering wave accounts for the conical double frequency emission. The gaps on the conical rings are observed and they are very sensitive to the propagation direction, and thus could be used to detect the small angle deviation of surface direction.

  4. Wafer-level pulsed-DC electromigration response at very high frequencies

    NASA Astrophysics Data System (ADS)

    Pierce, D. G.; Snyder, E. S.; Swanson, S. E.; Irwin, L. W.

    1994-03-01

    DC and pulsed-DC electromigration tests were performed at the Wafer-Level Pulsed-DC Electromigration Response and pulsed-DC electromigration tests were performed at the wafer level using standard and self-stressing test structures. DC characterization tests over a very large temperature range (180 to 560 C) were consistent with an interface diffusion mechanism in parallel with lattice diffusion. That data allowed for extraction of the respective activation energies and the diffusion coefficient of the rapid mechanism. The ability to extract simultaneously a defect-based diffusion coefficient and activation energy is significant given the extreme difficulty in making those measurements in aluminum. The pulsed-DC experiments were conducted over a range that includes the highest frequency to date, from DC to 500 MHz. Measurements were also made as a function of duty factor from 15% to 100% at selected frequencies. The data shows that the pulsed-DC lifetime is consistent with the average current density model at high (greater than 10 MHz) frequencies and showed no additional effects at the highest frequency tested (500 MHz). At low frequencies, we attribute the lessened enhancement to thermal effects rather than vacancy relaxation effects. Finally, the deviation in lifetime from the expected current density dependence, characterized over 1 and 1/2 orders of magnitude in current density, is explained in terms of a shift in the boundary condition for electromigration as the current density is decreased.

  5. Wafer-level pulsed-DC electromigration response at very high frequencies

    SciTech Connect

    Pierce, D.G.; Snyder, E.S.; Swanson, S.E.; Irwin, L.W.

    1994-03-01

    DC and pulsed-DC electromigration tests were performed at the Wafer-Level Pulsed-DC Electromigration Response and pulsed-DC electromigration tests were performed at the wafer level using standard and self-stressing test structures. DC characterization tests over a very large temperature range (180 to 560{degrees}C) were consistent with an interface diffusion mechanism in parallel with lattice diffusion. That data allowed for extraction of the respective activation energies and the diffusion coefficient of the rapid mechanism. The ability to extract simultaneously a defect-based diffusion coefficient and activation energy is significant given the extreme difficulty in making those measurements in aluminum. The pulsed-DC experiments were conducted over a range that includes the highest frequency to date, from DC to 500 MHz. Measurements were also made as a function of duty factor from 15% to 100% at selected frequencies. The data shows that the pulsed-DC lifetime is consistent with the average current density model at high (> 10 MHz) frequencies and showed no additional effects at the highest frequency tested (500 MHz). At low frequencies, we attribute the lessened enhancement to thermal effects rather than vacancy relaxation effects. Finally, the deviation in lifetime from the expected current density dependence, characterized over 1{1/2} orders of magnitude in current density, is explained in terms of a shift in the boundary condition for electromigration as the current density is decreased.

  6. Influences of impedance matching network on pulse-modulated radio frequency atmospheric pressure glow discharges

    SciTech Connect

    Huo, W. G.; Xu, K.; Sun, B.; Ding, Z. F.

    2012-08-15

    Pulse-modulated RF atmospheric pressure glow discharges (APDGs) were investigated in recent years to reduce the thermal accumulation and extend the operation region of the stable alpha glow mode. Different pulse-modulated voltage and current waveforms were acquired in previous experiments, but no attention was paid to the interpretation. We investigated this issue and associated phenomenon via positive and negative feedback effects derived from varying the series capacitor in the inversely L-shaped matching network used in our pulse-modulated RF APGD source. The evolutions of pulse-modulated RF waveforms were found to be associated with the feedback region and the pulsed plasma absorbed RF power. In the positive feedback region, pulse-modulated RF APGDs are relatively stable. In the negative feedback region, wide spikes as well as undershoots occur in RF voltage and current waveforms and the plasma absorbed RF power. In case of a high RF power discharge with a low modulation frequency, the pulse-modulated RF APGD is extinguished and re-ignited due to the enhanced undershoot during the initial pulse phase. The pulse-modulated RF APGD can transit from positive to negative feedback region in a range of series capacitance. Experimental results are discussed by the aid of equivalent circuit, negative and positive feedback effects.

  7. Frequency spectrum of induced transmembrane potential and permeabilization efficacy of bipolar electric pulses.

    PubMed

    Merla, Caterina; Pakhomov, Andrei G; Semenov, Iurii; Vernier, P Thomas

    2017-07-01

    In this paper a simple prediction method for the bipolar pulse cancellation effect is proposed, based on the frequency analysis of the TMP spectra of a single cell and the computed relative global spectral content up to a defined frequency threshold. We present a spectral analysis of pulses applied in experiments, and we extract the induced TMP from a microdosimetric model of the cell. The induced TMP computation is carried out on a hemispherical multi-layered cell model in the time domain. The analysis is presented for a variety of unipolar and bipolar input signals in the nanosecond and the microsecond time scales. Our evaluations are in good agreement with experimental results for bipolar pulse cancellation of electropermeabilization-induced Ca(2+) influx using 300ns, 750kV/m pulses and with other results reported in recent literature. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Method and means for generating a synchronizing pulse from a repetitive wave of varying frequency

    DOEpatents

    DeVolpi, Alexander; Pecina, Ronald J.; Travis, Dale J.

    1976-01-01

    An event that occurs repetitively at continuously changing frequencies can be used to generate a triggering pulse which is used to synchronize or control. The triggering pulse is generated at a predetermined percentage of the period of the repetitive waveform without regard to frequency. Counts are accumulated in two counters, the first counting during the "on" fraction of the period, and the second counting during the "off" fraction. The counts accumulated during each cycle are compared. On equality the trigger pulse is generated. Count input rates to each counter are determined by the ratio of the on-off fractions of the event waveform and the desired phase relationship. This invention is of particular utility in providing a trigger or synchronizing pulse during the open period of the shutter of a high-speed framing camera during its acceleration as well as its period of substantially constant speed.

  9. Propagation of nondiffracting pulses carrying orbital angular momentum at microwave frequencies

    NASA Astrophysics Data System (ADS)

    Comite, D.; Fuscaldo, W.; Pavone, S. C.; Valerio, G.; Ettorre, M.; Albani, M.; Galli, A.

    2017-03-01

    We discuss the generation and propagation of nondiffracting twisted pulses at microwaves, obtained through polychromatic spectral superposition of higher-order Bessel beams. The inherent vectorial structure of Maxwell's equations has been considered to generalize the nondiffracting solution of the scalar wave equation with azimuthal phase variation. Since a wide frequency bandwidth is necessary to synthesize time-limited pulses, the non-negligible wavenumber frequency dispersion, which commonly affects the propagation in the microwave range, has been taken into account. For this purpose, a higher-order Bessel beam is generated by enforcing an inward cylindrical traveling-wave distribution over a finite aperture. We present and discuss the main aspects of the generation of twisted pulses in the microwave range, showing the promising possibility to carry orbital angular momentum through highly focused X-shaped pulses up to the nondiffractive range.

  10. The Numerical Simulation of Jet Mixing With Steady and Antisymmetric Pulsed Jets in Different Frequency

    NASA Astrophysics Data System (ADS)

    Zhang, R. B.; Hong, L.

    2017-03-01

    A parametric study of the effect of rectangular antisymmetric pulsed control jets on the jet mixing with different pulse frequency is conducted using RANS simulation. The mean centerline potential core length and the axial velocity contours of the main jet at different downstream positions (x/D) is investigated and discussed in detail. When the antisymmetric pulsed control jets are injected into the main flow, a starting vortex is observed in the axial velocity contours on x-z plane, which does not exist when the control jets are symmetric steady (St=0). The factors that have effect on the jet mixing are analyzed and described in detail, and the jet/ambient air interfacial area is found to play an important role in jet mixing. The best mixing effect can be reached at the same mass flow ratio of the main flow to the control jets if a proper pulse frequency of the control jets is used.

  11. 1W frequency-doubled VCSEL-pumped blue laser with high pulse energy

    NASA Astrophysics Data System (ADS)

    Van Leeuwen, Robert; Chen, Tong; Watkins, Laurence; Xu, Guoyang; Seurin, Jean-Francois; Wang, Qing; Zhou, Delai; Ghosh, Chuni

    2015-02-01

    We report on a Q-switched VCSEL side-pumped 946 nm Nd:YAG laser that produces high average power blue light with high pulse energy after frequency doubling in BBO. The gain medium was water cooled and symmetrically pumped by three 1 kW 808 nm VCSEL pump modules. More than 1 W blue output was achieved at 210 Hz with 4.9 mJ pulse energy and at 340 Hz with 3.2 mJ pulse energy, with 42% and 36% second harmonic conversion efficiency respectively. Higher pulse energy was obtained at lower repetition frequencies, up to 9.3 mJ at 70 Hz with 52% conversion efficiency.

  12. System for adjusting frequency of electrical output pulses derived from an oscillator

    DOEpatents

    Bartholomew, David B.

    2006-11-14

    A system for setting and adjusting a frequency of electrical output pulses derived from an oscillator in a network is disclosed. The system comprises an accumulator module configured to receive pulses from an oscillator and to output an accumulated value. An adjustor module is configured to store an adjustor value used to correct local oscillator drift. A digital adder adds values from the accumulator module to values stored in the adjustor module and outputs their sums to the accumulator module, where they are stored. The digital adder also outputs an electrical pulse to a logic module. The logic module is in electrical communication with the adjustor module and the network. The logic module may change the value stored in the adjustor module to compensate for local oscillator drift or change the frequency of output pulses. The logic module may also keep time and calculate drift.

  13. A novel pulse compression algorithm for frequency modulated active thermography using band-pass filter

    NASA Astrophysics Data System (ADS)

    Chatterjee, Krishnendu; Roy, Deboshree; Tuli, Suneet

    2017-05-01

    This paper proposes a novel pulse compression algorithm, in the context of frequency modulated thermal wave imaging. The compression filter is derived from a predefined reference pixel in a recorded video, which contains direct measurement of the excitation signal alongside the thermal image of a test piece. The filter causes all the phases of the constituent frequencies to be adjusted to nearly zero value, so that on reconstruction a pulse is obtained. Further, due to band-limited nature of the excitation, signal-to-noise ratio is improved by suppressing out-of-band noise. The result is similar to that of a pulsed thermography experiment, although the peak power is drastically reduced. The algorithm is successfully demonstrated on mild steel and carbon fibre reference samples. Objective comparisons of the proposed pulse compression algorithm with the existing techniques are presented.

  14. Direct ultrashort-pulse intensity and phase retrieval by frequency-resolved optical gating and a computational neural network.

    PubMed

    Krumbügel, M A; Ladera, C L; Delong, K W; Fittinghoff, D N; Sweetser, J N; Trebino, R

    1996-01-15

    Ultrashort-laser-pulse retrieval in frequency-resolved optical gating has previously required an iterative algorithm. Here, however, we show that a computational neural network can directly and rapidly recover the intensity and phase of a pulse.

  15. Pulse evolution in nonlinear optical fibers with sliding-frequency filters.

    PubMed

    Beech-Brandt, J J; Smyth, N F

    2001-05-01

    The effect of fiber loss, amplification, and sliding-frequency filters on the evolution of optical pulses in nonlinear optical fibers is considered, this evolution being governed by a perturbed nonlinear Schrödinger (NLS) equation. Approximate ordinary differential equations (ODE's) governing the pulse evolution are obtained using conservation and moment equations for the perturbed NLS equation together with a trial function incorporating a solitonlike pulse with independently varying amplitude and width. In addition, the trial function incorporates the interaction between the pulse and the dispersive radiation shed as the pulse evolves. This interaction must be included in order to obtain approximate ODE's whose solutions are in good agreement with full numerical solutions of the governing perturbed NLS equation. The solutions of the approximate ODE's are compared with full numerical solutions of the perturbed NLS equation and very good agreement is found.

  16. Pulsed radio frequency interference effects on data communications via satellite transponder

    NASA Technical Reports Server (NTRS)

    Weinberg, A.; Hong, Y.

    1979-01-01

    Power-limited communication links may be susceptible to significant degradation if intentional or unintentional pulsed high level radio frequency interference (RFI) is present. Pulsed RFI is, in fact, of current interest to NASA in studies relating to its Tracking and Data Relay Satellite System (TDRSS). The present paper examines the impact of pulsed RFI on the error probability performance of a power-limited satellite communication link: the assumed modulation scheme is PN coded binary PSK. The composite effects of thermal noise, pulsed CW and pulsed Gaussian noise are analyzed, where RFI arrivals are assumed to follow Poisson statistics. Under the assumption that the satellite repeater is ideal and that integrate and dump filtering is employed at the ground receiver, an exact error probability expression and associated approximations are derived. Computed results are generated using an arbitrarily specified RFI model.

  17. Time-frequency dynamics of superluminal pulse transition to the subluminal regime

    NASA Astrophysics Data System (ADS)

    Dorrah, Ahmed H.; Ramakrishnan, Abhinav; Mojahedi, Mo

    2015-03-01

    Spectral reshaping and nonuniform phase delay associated with an electromagnetic pulse propagating in a temporally dispersive medium may lead to interesting observations in which the group velocity becomes superluminal or even negative. In such cases, the finite bandwidth of the superluminal region implies the inevitable existence of a cutoff distance beyond which a superluminal pulse becomes subluminal. In this paper, we derive a closed-form analytic expression to estimate this cutoff distance in abnormal dispersive media with gain. Moreover, the method of steepest descent is used to track the time-frequency dynamics associated with the evolution of the center of mass of a superluminal pulse to the subluminal regime. This evolution takes place at longer propagation depths as a result of the subluminal components affecting the behavior of the pulse. Finally, the analysis presents the fundamental limitations of superluminal propagation in light of factors such as the medium depth, pulse width, and the medium dispersion strength.

  18. Frequency-resolved optical gating for characterization of VUV pulses using ultrafast plasma mirror switching.

    PubMed

    Itakura, Ryuji; Kumada, Takayuki; Nakano, Motoyoshi; Akagi, Hiroshi

    2015-05-04

    We propose and experimentally demonstrate a method for characterizing vacuum ultraviolet (VUV) pulses based on time-resolved reflection spectroscopy of fused silica pumped by an intense laser pulse. Plasma mirror reflection is used as an ultrafast optical switch, which enables us to measure frequency-resolved optical gating (FROG) traces. The VUV temporal waveform can be retrieved from the measured FROG trace using principal component generalized projections algorithm with modification. The temporal profile of the plasma mirror reflectivity is also extracted simultaneously.

  19. Ultrahigh contrast from a frequency-doubled chirped-pulse-amplification beamline.

    PubMed

    Hillier, David; Danson, Colin; Duffield, Stuart; Egan, David; Elsmere, Stephen; Girling, Mark; Harvey, Ewan; Hopps, Nicholas; Norman, Michael; Parker, Stefan; Treadwell, Paul; Winter, David; Bett, Thomas

    2013-06-20

    This paper describes frequency-doubled operation of a high-energy chirped-pulse-amplification beamline. Efficient type-I second-harmonic generation was achieved using a 3 mm thick 320 mm aperture KDP crystal. Shots were fired at a range of energies achieving more than 100 J in a subpicosecond, 527 nm laser pulse with a power contrast of 10(14).

  20. Shaping pulses using frequency conversion with a modulated picosecond free electron laser

    SciTech Connect

    Hooper, B.A.; Madey, J.M.J.

    1995-12-31

    Computer simulations and experiments indicate that we can shape the infrared picosecond pulses of the Mark III FEL in amplitude, frequency, and phase. Strongly modulated fundamental and second harmonic pulses have been generated by operating the Mark III FEL in the regime of strong sideband growth. In this paper, we present the results of simulations and experiments for second harmonic generation with fundamental inputs from 2 to 3 {mu}m.

  1. Variable pulse repetition frequency output from an optically injected solid state laser.

    PubMed

    Kane, D M; Toomey, J P

    2011-02-28

    An optically injected solid state laser (OISSL) system is known to generate complex nonlinear dynamics within the parameter space of varying the injection strength of the master laser and the frequency detuning between the master and slave lasers. Here we show that within these complex nonlinear dynamics, a system which can be operated as a source of laser pulses with a pulse repetition frequency (prf) that can be continuously varied by a single control, is embedded. Generation of pulse repetition frequencies ranging from 200 kHz up to 4 MHz is shown to be achievable for an optically injected Nd:YVO4 solid state laser system from analysis of prior experimental and simulation results. Generalizing this to other optically injected solid state laser systems, the upper bound on the repetition frequency is of order the relaxation oscillation frequency for the lasers. The system is discussed in the context of prf versatile laser systems more generally. Proposals are made for the next generation of OISSLs that will increase understanding of the variable pulse repetition frequency operation, and determine its practical limitations. Such variable prf laser systems; both low powered, and, higher powered systems achieved using one or more optical power amplifier stages; have many potential applications from interrogating resonance behaviors in microscale structures, through sensing and diagnostics, to laser processing.

  2. Pulsed frequency-shifted feedback laser for laser guide stars: intracavity preamplifier.

    PubMed

    Pique, Jean-Paul; Fesquet, Vincent; Jacob, Sylvie

    2011-11-20

    Intensive use of laser guide stars with the new generation of extremely large telescopes and hypertelescopes will require the use of more efficient lasers to surmount novel limitations and aberrations. The pulsed frequency-shifted feedback (FSF) laser we have developed overcomes the saturation of sodium atoms and solves the new problems. This work presents a highly efficient solution for operating pulsed FSF lasers. For the first time, an intracavity preamplifier achieves a gain of 10(4) and more than 40 μJ per pulse, with a near-diffraction-limited beam and without amplified spontaneous emission. Endurance tests have shown that good performance is maintained over several hundred hours.

  3. Laser-induced resonance states as dynamic suppressors of ionization in high-frequency short pulses

    SciTech Connect

    Barash, Danny; Orel, Ann E.; Baer, Roi

    2000-01-01

    An adiabatic-Floquet formalism is used to study the suppression of ionization in short laser pulses. In the high-frequency limit the adiabatic equations involve only the pulse envelope where transitions are purely ramp effects. For a short-ranged potential having a single-bound state we show that ionization suppression is caused by the appearance of a laser-induced resonance state, which is coupled by the pulse ramp to the ground state and acts to trap ionizing flux. (c) 1999 The American Physical Society.

  4. Pulse width dependence of Brillouin frequency in single mode optical fibers.

    PubMed

    Cho, Seok-Beom; Kim, Young-Gyu; Heo, Jin-Seok; Lee, Jung-Ju

    2005-11-14

    Stimulated Brillouin scattering in optical fibers can be used to measure strain or temperature in a distributed manner. Brillouin optical time domain analysis (BOTDA) is the most common sensor system based on the Brillouin scattering. This paper presents the experimental analysis of the characteristics of Brillouin gain spectrum (BGS) influenced by the width of launched pulse. Brillouin strain coefficient is also examined for the different pulse widths, which is important to apply a Brillouin scattering-based sensor to a structural health monitoring. Experimental results showed that not only the Brillouin linewidth and gain but also the Brillouin frequency were dependent on the pulse widths.

  5. Wakefield evolution and electron acceleration in interaction of frequency-chirped laser pulse with inhomogeneous plasma

    NASA Astrophysics Data System (ADS)

    Rezaei-Pandari, M.; Niknam, A. R.; Massudi, R.; Jahangiri, F.; Hassaninejad, H.; Khorashadizadeh, S. M.

    2017-02-01

    The nonlinear interaction of an ultra-short intense frequency-chirped laser pulse with an underdense plasma is studied. The effects of plasma inhomogeneity and laser parameters such as chirp, pulse duration, and intensity on plasma density and wakefield evolutions, and electron acceleration are examined. It is found that a properly chirped laser pulse could induce a stronger laser wakefield in an inhomogeneous plasma and result in higher electron acceleration energy. It is also shown that the wakefield amplitude is enhanced by increasing the slope of density in the inhomogeneous plasma.

  6. Generation of Low-Frequency Electromagnetic Waves by Spectrally Broad Intense Laser Pulses in a Plasma

    NASA Astrophysics Data System (ADS)

    Tsintsadze, L. N.; Tajima, T.; Nishikawa, K.; Koga, J. K.; Nakagawa, K.; Kishimoto, Y.

    A new mechanism for the emission of low-frequency electromagnetic (EM) waves, including the generation of a quasistatic magnetic field, by a relativistically intense laser pulse with a wide spectrum is presented. The emission is due to modulational and filamentational instabilities of the photon gas in a plasma. The generation of the magnetic field is associated with a significant change in the laser pulse shape during the propagation. This process is identified in our 2D particle-in-cell (PIC) simulations with a high intensity (1019pulse.

  7. Stimulated Raman scattering in hydrogen by frequency-doubled amplified femtosecond Ti:sapphire laser pulses

    NASA Astrophysics Data System (ADS)

    Krylov, V.; Rebane, A.; Ollikainen, O.; Erni, D.; Wild, Urs P.; Bespalov, V.; Staselko, D.

    1996-03-01

    We present results on stimulated Raman scattering in hydrogen excited by 200-fs-duration 1-kHz repetition-rate and 0.6-W average-power Ti:sapphire (780-nm) and 0.2-W average-power second-harmonic (390-nm) laser pulses with linear and circular polarizations. Spectral and temporal measurements of the vibrational and rotational components at Stokes and anti-Stokes frequencies in the wavelength range of 289-1154 nm are reported. We observe threefold shortening of the first vibrational Stokes component pulses, excited by 400-fs-duration second-harmonic pulses.

  8. [Pulsed low-frequency electrotherapy of vibration disease associated with osteoarthrosis].

    PubMed

    Chudinova, O A; Fedorov, A A; Venediktov, D L; Samokhvalova, G N; Il'ina, M I; Budlianskaia, S V

    2010-01-01

    The study involving 185 patients with vibration disease and concomitant osteoarthrosis has demonstrated the positive influence of pulsed low-frequency currents in combination with hydrogen sulphide baths on the clinical course of the disease. This combined therapy produced good immediate and late post-treatment results. The data obtained suggest high efficiency of differential application of complex-modulated pulsed and fluctuating currents in patients with vibration disease. It is concluded that amplipulse therapy is the method of choice for the management of this pathology in the absence of apparatuses emitting pulsed currents in the running way regime.

  9. A piezoelectric pulse generator for low frequency non-harmonic vibration

    NASA Astrophysics Data System (ADS)

    Jiang, Hao; Yeatman, Eric M.

    2013-12-01

    This paper reports a new piezoelectric prototype for pulse generation by energy harvesting from low frequency non-harmonic vibration. The pulse generator presented here consists of two parts: the electromechanical part and the load circuit. A metal rolling rod is used as the proof mass, moving along the substrate to achieve both actuating of the piezoelectric cantilever by magnetic coupling and self-synchronous switching of the circuit. By using this new approach, the energy from the piezoelectric transduction mechanism is regulated simultaneously when it is extracted. This allows a series of tuneable pulses to be generated, which can be applied to self-powered RF wireless sensor network (WSN) nodes.

  10. Cross-correlation frequency-resolved optical gating for characterization of an ultrashort optical pulse train

    NASA Astrophysics Data System (ADS)

    Nakano, Yuta; Imasaka, Totaro

    2017-05-01

    A technique involving cross-correlation frequency-resolved optical gating is applied in characterizing an optical pulse train consisting of several spectral components. An optical beat was used as a reference pulse for measuring the relative spectral phase among the spectral components in the test pulse generated by four-wave Raman mixing in hydrogen gas. It was confirmed that a change in the relative phase can be measured by monitoring the shift in the interference fringe and that Raman emissions generated by four-wave Raman mixing are phase locked.

  11. Interaction of frequency modulated light pulses with rubidium atoms in a magneto-optical trap

    NASA Astrophysics Data System (ADS)

    Bakos, J. S.; Djotyan, G. P.; Ignácz, P. N.; Kedves, M. Á.; Serényi, M.; Sörlei, Zs.; Szigeti, J.; Tóth, Z.

    2006-07-01

    The spatial displacement of the 85Rb atoms in a Magneto-Optical Trap (MOT) under the influence of series of frequency modulated light pulse pairs propagating opposite to each other is measured as a function of the time elapsed after the start of the pulse train, and compared with the results of simulations. Adiabatic excitation and consecutive de-excitation take place between the ground 52S1/2 (F=3) and the 52P3/2 (F'=2, 3, 4) excited levels as the result of the interaction. The displacement of the 85Rb atoms is calculated as the solution of simple equation of motion where the expelling force is that arising from the action of the frequency modulated light pulses. The restoring and friction forces of the MOT are taken into account also. The system of Bloch equations for the density matrix elements is solved numerically for transitions between six working hyperfine levels of the atom interacting with the sequence of the frequency modulated laser pulses. According to these simulations, the momentum transferred by one pulse pair is always smaller than the expected 2ħk, (1) where ħ is the Plank constant and k=2π/λ where λ is the wavelength, (2) having a maximum value in a restricted region of variation of the laser pulse peak intensity and the chirp.

  12. Transient plasma potential in pulsed dual frequency inductively coupled plasmas and effect of substrate biasing

    SciTech Connect

    Mishra, Anurag; Yeom, Geun Young

    2016-09-15

    An electron emitting probe in saturated floating potential mode has been used to investigate the temporal evolution of plasma potential and the effect of substrate RF biasing on it for pulsed dual frequency (2 MHz/13.56 MHz) inductively coupled plasma (ICP) source. The low frequency power (P{sub 2MHz}) has been pulsed at 1 KHz and a duty ratio of 50%, while high frequency power (P{sub 13.56MHz}) has been used in continuous mode. The substrate has been biased with a separate bias power at (P{sub 12.56MHz}) Argon has been used as a discharge gas. During the ICP power pulsing, three distinct regions in a typical plasma potential profile, have been identified as ‘initial overshoot’, pulse ‘on-phase’ and pulse ‘off-phase’. It has been found out that the RF biasing of the substrate significantly modulates the temporal evolution of the plasma potential. During the initial overshoot, plasma potential decreases with increasing RF biasing of the substrate, however it increases with increasing substrate biasing for pulse ‘on-phase’ and ‘off-phase’. An interesting structure in plasma potential profile has also been observed when the substrate bias is applied and its evolution depends upon the magnitude of bias power. The reason of the evolution of this structure may be the ambipolar diffusion of electron and its dependence on bias power.

  13. Transient plasma potential in pulsed dual frequency inductively coupled plasmas and effect of substrate biasing

    NASA Astrophysics Data System (ADS)

    Mishra, Anurag; Yeom, Geun Young

    2016-09-01

    An electron emitting probe in saturated floating potential mode has been used to investigate the temporal evolution of plasma potential and the effect of substrate RF biasing on it for pulsed dual frequency (2 MHz/13.56 MHz) inductively coupled plasma (ICP) source. The low frequency power (P2MHz) has been pulsed at 1 KHz and a duty ratio of 50%, while high frequency power (P13.56MHz) has been used in continuous mode. The substrate has been biased with a separate bias power at (P12.56MHz) Argon has been used as a discharge gas. During the ICP power pulsing, three distinct regions in a typical plasma potential profile, have been identified as `initial overshoot', pulse `on-phase' and pulse `off-phase'. It has been found out that the RF biasing of the substrate significantly modulates the temporal evolution of the plasma potential. During the initial overshoot, plasma potential decreases with increasing RF biasing of the substrate, however it increases with increasing substrate biasing for pulse `on-phase' and `off-phase'. An interesting structure in plasma potential profile has also been observed when the substrate bias is applied and its evolution depends upon the magnitude of bias power. The reason of the evolution of this structure may be the ambipolar diffusion of electron and its dependence on bias power.

  14. Odors Pulsed at Wing Beat Frequencies are Tracked by Primary Olfactory Networks and Enhance Odor Detection

    PubMed Central

    Tripathy, Shreejoy J.; Peters, Oakland J.; Staudacher, Erich M.; Kalwar, Faizan R.; Hatfield, Mandy N.; Daly, Kevin C.

    2009-01-01

    Each down stroke of an insect's wings accelerates axial airflow over the antennae. Modeling studies suggest that this can greatly enhance penetration of air and air-born odorants through the antennal sensilla thereby periodically increasing odorant-receptor interactions. Do these periodic changes result in entrainment of neural responses in the antenna and antennal lobe (AL)? Does this entrainment affect olfactory acuity? To address these questions, we monitored antennal and AL responses in the moth Manduca sexta while odorants were pulsed at frequencies from 10–72 Hz, encompassing the natural wingbeat frequency. Power spectral density (PSD) analysis was used to identify entrainment of neural activity. Statistical analysis of PSDs indicates that the antennal nerve tracked pulsed odor up to 30 Hz. Furthermore, at least 50% of AL local field potentials (LFPs) and between 7–25% of unitary spiking responses also tracked pulsed odor up to 30 Hz in a frequency-locked manner. Application of bicuculline (200 μM) abolished pulse tracking in both LFP and unitary responses suggesting that GABAA receptor activation is necessary for pulse tracking within the AL. Finally, psychophysical measures of odor detection establish that detection thresholds are lowered when odor is pulsed at 20 Hz. These results suggest that AL networks can respond to the oscillatory dynamics of stimuli such as those imposed by the wing beat in a manner analogous to mammalian sniffing. PMID:20407584

  15. Measurement of electron density transients in pulsed RF discharges using a frequency boxcar hairpin probe

    NASA Astrophysics Data System (ADS)

    Peterson, David; Coumou, David; Shannon, Steven

    2015-11-01

    Time resolved electron density measurements in pulsed RF discharges are shown using a hairpin resonance probe using low cost electronics, on par with normal Langmuir probe boxcar mode operation. Time resolution of 10 microseconds has been demonstrated. A signal generator produces the applied microwave frequency; the reflected waveform is passed through a directional coupler and filtered to remove the RF component. The signal is heterodyned with a frequency mixer and rectified to produce a DC signal read by an oscilloscope. At certain points during the pulse, the plasma density is such that the applied frequency is the same as the resonance frequency of the probe/plasma system, creating reflected signal dips. The applied microwave frequency is shifted in small increments in a frequency boxcar routine to determine the density as a function of time. A dc sheath correction is applied for the grounded probe, producing low cost, high fidelity, and highly reproducible electron density measurements. The measurements are made in both inductively and capacitively coupled systems, the latter driven by multiple frequencies where a subset of these frequencies are pulsed. Measurements are compared to previous published results, time resolved OES, and in-line measurement of plasma impedance. This work is supported by the NSF DOE partnership on plasma science, the NSF GOALI program, and MKS Instruments.

  16. Investigation of pulsed mode operation with the frequency tuned CAPRICE ECRIS

    SciTech Connect

    Maimone, F. Tinschert, K.; Endermann, M.; Hollinger, R.; Kondrashev, S.; Lang, R.; Mäder, J.; Patchakui, P. T.; Spädtke, P.

    2016-02-15

    In order to increase the intensity of the highly charged ions produced by the Electron Cyclotron Resonance Ion Sources (ECRISs), techniques like the frequency tuning and the afterglow mode have been developed and in this paper the effect on the ion production is shown for the first time when combining both techniques. Recent experimental results proved that the tuning of the operating frequency of the ECRIS is a promising technique to achieve higher ion currents of higher charge states. On the other hand, it is well known that the afterglow mode of the ECRIS operation can provide more intense pulsed ion beams in comparison with the continuous wave (cw) operation. These two techniques can be combined by pulsing the variable frequency signal driving the traveling wave tube amplifier which provides the high microwave power to the ECRIS. In order to analyze the effect of these two combined techniques on the ion source performance, several experiments were carried out on the pulsed frequency tuned CAPRICE (Compacte source A Plusiers Résonances Ionisantes Cyclotron Electroniques)-type ECRIS. Different waveforms and pulse lengths have been investigated under different settings of the ion source. The results of the pulsed mode have been compared with those of cw operation.

  17. Investigation of pulsed mode operation with the frequency tuned CAPRICE ECRIS.

    PubMed

    Maimone, F; Tinschert, K; Endermann, M; Hollinger, R; Kondrashev, S; Lang, R; Mäder, J; Patchakui, P T; Spädtke, P

    2016-02-01

    In order to increase the intensity of the highly charged ions produced by the Electron Cyclotron Resonance Ion Sources (ECRISs), techniques like the frequency tuning and the afterglow mode have been developed and in this paper the effect on the ion production is shown for the first time when combining both techniques. Recent experimental results proved that the tuning of the operating frequency of the ECRIS is a promising technique to achieve higher ion currents of higher charge states. On the other hand, it is well known that the afterglow mode of the ECRIS operation can provide more intense pulsed ion beams in comparison with the continuous wave (cw) operation. These two techniques can be combined by pulsing the variable frequency signal driving the traveling wave tube amplifier which provides the high microwave power to the ECRIS. In order to analyze the effect of these two combined techniques on the ion source performance, several experiments were carried out on the pulsed frequency tuned CAPRICE (Compacte source A Plusiers Résonances Ionisantes Cyclotron Electroniques)-type ECRIS. Different waveforms and pulse lengths have been investigated under different settings of the ion source. The results of the pulsed mode have been compared with those of cw operation.

  18. The role of LH in ovarian stimulation.

    PubMed

    Munoz, Elkin; Bosch, Ernesto; Fernandez, Iria; Portela, Susana; Ortiz, Ginna; Remohi, Jose; Pellicer, Antonio

    2012-03-01

    LH is a glycoprotein that plays a crucial role in folliculogenesis during the natural ovarian cycles. It has the same activity and shares receptors with hCG. However the use of LH in combination with FSH in controlled ovarian stimulation remains controversial. A practical approach concerning the usefulness of LH according to the endogenous level of LH is described herein. Specific groups of patients can benefit from ovarian stimulation with LH. New applications of LH/hCG activity are also discussed.

  19. Beam Wiggler operating in high frequency and single-pulse modes

    NASA Astrophysics Data System (ADS)

    Goltsov, A. Y.; Kolomiysky, Arkadiy N.; Kovalsky, N. G.; Kryzhko, V. V.; Manes, Kenneth R.; Pergament, Michael I.

    1999-07-01

    The possibility to control an intensity distribution in the far field of a powerful laser system by rapid motion of a focal spot is considered. Quadruple electro optic deflector on the base of LiNgO3 crystal installed in resonance capacity with 1 cm clear aperture has been developed, constructed and tested both in high frequency and single pulse operation modes. The main parameters of the device are as follows: amplitude of the angular deflection +/- 4 dif. limits at 6.5 GHz operation frequency, total angular deflection 12 dif. limits in the single ns-pulse operation mode. Results of the Beam Wiggler dynamic testing are presented and discussed.

  20. Frequency adjustment and synchrony in networks of delayed pulse-coupled oscillators

    NASA Astrophysics Data System (ADS)

    Nishimura, Joel

    2015-01-01

    We introduce a system of pulse-coupled oscillators that can change both their phases and frequencies and prove that when there is a separation of time scales between phase and frequency adjustment the system converges to exact synchrony on strongly connected graphs with time delays. The analysis involves decomposing the network into a forest of tree-like structures that capture causality. These results provide a robust method of sensor net synchronization as well as demonstrate a new avenue of possible pulse-coupled oscillator research.

  1. Vibrotactile Sensory Substitution for Object Manipulation: Amplitude versus Pulse Train Frequency Modulation

    PubMed Central

    Stepp, Cara E.; Matsuoka, Yoky

    2012-01-01

    Incorporating sensory feedback with prosthetic devices is now possible, but the optimal methods of providing such feedback are still unknown. The relative utility of amplitude and pulse train frequency modulated stimulation paradigms for providing vibrotactile feedback for object manipulation was assessed in 10 participants. The two approaches were studied during virtual object manipulation using a robotic interface as a function of presentation order and a simultaneous cognitive load. Despite the potential pragmatic benefits associated with pulse train frequency modulated vibrotactile stimulation, comparison of the approach with amplitude modulation indicates that amplitude modulation vibrotactile stimulation provides superior feedback for object manipulation. PMID:21997322

  2. LH2 airport requirements study

    NASA Technical Reports Server (NTRS)

    Brewer, G. D. (Editor)

    1976-01-01

    A preliminary assessment of the facilities and equipment which will be required at a representative airport is provided so liquid hydrogen LH2 can be used as fuel in long range transport aircraft in 1995-2000. A complete facility was conceptually designed, sized to meet the projected air traffic requirement. The facility includes the liquefaction plant, LH2, storage capability, and LH2 fuel handling system. The requirements for ground support and maintenance for the LH2 fueled aircraft were analyzed. An estimate was made of capital and operating costs which might be expected for the facility. Recommendations were made for design modifications to the reference aircraft, reflecting results of the analysis of airport fuel handling requirements, and for a program of additional technology development for air terminal related items.

  3. Intense, carrier frequency and bandwidth tunable quasi single-cycle pulses from an organic emitter covering the Terahertz frequency gap

    PubMed Central

    Vicario, C.; Monoszlai, B.; Jazbinsek, M.; Lee, S. -H.; Kwon, O. -P.; Hauri, C. P.

    2015-01-01

    In Terahertz (THz) science, one of the long-standing challenges has been the formation of spectrally dense, single-cycle pulses with tunable duration and spectrum across the frequency range of 0.1–15 THz (THz gap). This frequency band, lying between the electronically and optically accessible spectra hosts important molecular fingerprints and collective modes which cannot be fully controlled by present strong-field THz sources. We present a method that provides powerful single-cycle THz pulses in the THz gap with a stable absolute phase whose duration can be continuously selected between 68 fs and 1100 fs. The loss-free and chirp-free technique is based on optical rectification of a wavelength-tunable pump pulse in the organic emitter HMQ-TMS that allows for tuning of the spectral bandwidth from 1 to more than 7 octaves over the entire THz gap. The presented source tunability of the temporal carrier frequency and spectrum expands the scope of spectrally dense THz sources to time-resolved nonlinear THz spectroscopy in the entire THz gap. This opens new opportunities towards ultrafast coherent control over matter and light. PMID:26400005

  4. Intense, carrier frequency and bandwidth tunable quasi single-cycle pulses from an organic emitter covering the Terahertz frequency gap

    NASA Astrophysics Data System (ADS)

    Vicario, C.; Monoszlai, B.; Jazbinsek, M.; Lee, S.-H.; Kwon, O.-P.; Hauri, C. P.

    2015-09-01

    In Terahertz (THz) science, one of the long-standing challenges has been the formation of spectrally dense, single-cycle pulses with tunable duration and spectrum across the frequency range of 0.1-15 THz (THz gap). This frequency band, lying between the electronically and optically accessible spectra hosts important molecular fingerprints and collective modes which cannot be fully controlled by present strong-field THz sources. We present a method that provides powerful single-cycle THz pulses in the THz gap with a stable absolute phase whose duration can be continuously selected between 68 fs and 1100 fs. The loss-free and chirp-free technique is based on optical rectification of a wavelength-tunable pump pulse in the organic emitter HMQ-TMS that allows for tuning of the spectral bandwidth from 1 to more than 7 octaves over the entire THz gap. The presented source tunability of the temporal carrier frequency and spectrum expands the scope of spectrally dense THz sources to time-resolved nonlinear THz spectroscopy in the entire THz gap. This opens new opportunities towards ultrafast coherent control over matter and light.

  5. Extreme-ultraviolet frequency combs from high-order harmonic generation with few-cycle pulse trains

    NASA Astrophysics Data System (ADS)

    Tudorovskaya, Maria; Lein, Manfred

    2017-04-01

    The spectrum of a high-repetition train of laser pulses consists of many equally spaced lines, forming an optical frequency comb which is useful for high-precision spectroscopy. By exposing atoms to a train of strong pulses, frequency combs reaching into the extreme ultraviolet may be produced via high-order harmonic generation. Here, we report a theoretical study of extreme-ultraviolet frequency-comb generation by trains of few-cycle pulses. We analyze the nontrivial comb structure arising from overlapping harmonic orders. The spacings of the comb lines and their dependence on the offset frequency of the incident pulse train are discussed.

  6. Pulsed, controlled, frequency-chirped laser light at GHz detunings for atomic physics experiments

    NASA Astrophysics Data System (ADS)

    Kaufman, B.; Paltoo, T.; Grogan, T.; Pena, T.; John, J. P. St.; Wright, M. J.

    2017-02-01

    We have developed a means to control rapidly frequency-chirped laser light at large detuning, by controlling the input modulation frequency of a ˜7 GHz signal into an electro-optical phase modulator in an injection-locked laser system. We show that we can extend the capabilities of the system to effectively pulse the laser on timescales less than 3 ns by turning the injection lock on/off and create arbitrary frequency-chirp shapes on the laser on the tens of nanosecond time scales. We have been able to use this pulsed frequency-chirped laser to control the excitation of a thermal Rb gas via rapid adiabatic passage.

  7. Frequency-resolved optical gating measurement of ultrashort pulses by using single nanowire

    NASA Astrophysics Data System (ADS)

    Yu, Jiaxin; Liao, Feng; Gu, Fuxing; Zeng, Heping

    2016-09-01

    The use of ultrashort pulses for fundamental studies and applications has been increasing rapidly in the past decades. Along with the development of ultrashort lasers, exploring new pulse diagnositic approaches with higher signal-to-noise ratio have attracted great scientific and technological interests. In this work, we demonstrate a simple technique of ultrashort pulses characterization with a single semiconductor nanowire. By performing a frequency-resolved optical gating method with a ZnO nanowire coupled to tapered optical microfibers, the phase and amplitude of a pulse series are extracted. The generated signals from the transverse frequency conversion process can be spatially distinguished from the input, so the signal-to-noise ratio is improved and permits lower energy pulses to be identified. Besides, since the nanometer scale of the nonlinear medium provides relaxed phase-matching constraints, a measurement of 300-nm-wide supercontinuum pulses is achieved. This system is highly compatible with standard optical fiber systems, and shows a great potential for applications such as on-chip optical communication.

  8. Frequency-resolved optical gating measurement of ultrashort pulses by using single nanowire

    PubMed Central

    Yu, Jiaxin; Liao, Feng; Gu, Fuxing; Zeng, Heping

    2016-01-01

    The use of ultrashort pulses for fundamental studies and applications has been increasing rapidly in the past decades. Along with the development of ultrashort lasers, exploring new pulse diagnositic approaches with higher signal-to-noise ratio have attracted great scientific and technological interests. In this work, we demonstrate a simple technique of ultrashort pulses characterization with a single semiconductor nanowire. By performing a frequency-resolved optical gating method with a ZnO nanowire coupled to tapered optical microfibers, the phase and amplitude of a pulse series are extracted. The generated signals from the transverse frequency conversion process can be spatially distinguished from the input, so the signal-to-noise ratio is improved and permits lower energy pulses to be identified. Besides, since the nanometer scale of the nonlinear medium provides relaxed phase-matching constraints, a measurement of 300-nm-wide supercontinuum pulses is achieved. This system is highly compatible with standard optical fiber systems, and shows a great potential for applications such as on-chip optical communication. PMID:27609521

  9. Collisionless expansion of pulsed radio frequency plasmas. I. Front formation

    NASA Astrophysics Data System (ADS)

    Schröder, T.; Grulke, O.; Klinger, T.; Boswell, R. W.; Charles, C.

    2016-01-01

    The dynamics during plasma expansion are studied with the use of a versatile particle-in-cell simulation with a variable neutral gas density profile. The simulation is tailored to a radio frequency plasma expansion experiment [Schröder et al., J. Phys. D: Appl. Phys. 47(5), 055207 (2014)]. The experiment has shown the existence of a propagating ion front. The ion front features a strong electric field and features a sharp plasma potential drop similar to a double layer. However, the presented results of a first principle simulation show that, in general, the ion front does not have to be entangled with an electric field. The propagating electric field reflects the downstream ions, which stream with velocities up to twice as high as that of the ion front propagation. The observed ion density peak forms due to the accumulation of the reflected ions. The simulation shows that the ion front formation strongly depends on the initial ion density profile and is subject to a wave-breaking phenomenon. Virtual diagnostics in the code allow for a direct comparison with experimental results. Using this technique, the plateau forming in the wake of the plasma front could be indirectly verified in the expansion experiment. Although the simulation considers profiles only in one spatial dimensional, its results are qualitatively in a very good agreement with the laboratory experiment. It can successfully reproduce findings obtained by independent numerical models and simulations. This indicates that the effects of magnetic field structures and tangential inhomogeneities are not essential for the general expansion dynamic. The presented simulation will be used for a detailed parameter study dealt with in Paper II [Schröder et al., Phys. Plasma 23, 013512 (2016)] of this series.

  10. Quantum control of ultracold atoms and molecules via linearly chirped laser pulses and optical frequency combs

    NASA Astrophysics Data System (ADS)

    Collins, Thomas A.

    This work investigates the potential of performing high yield quantum control operations on atomic and molecular systems using frequency modulated laser fields. The effectiveness of a single laser pulse in creating desired superposition states within the valence shell of Rubidium and the utilization of a single pulse train in order to perform internal state cooling of diatomic hetero-nuclear molecules, in this case KRb, are investigated. These methods are an alternative to the current protocol in the field of quantum control which typically calls for the employment of two laser fields, be they single pulses or pulse trains. Manipulation of the state of the valence electron within Rubidium was studied for two different models of the hyperfine levels of the 5s and 5p orbitals: a three level Λ system and the more realistic four level system accounting for all allowed optical transitions. Numerical analysis of the population dynamics that occur within the system during the time of interaction with the pulse was carried out for various values of the field parameters as well as for two different forms of the pulse envelope. Population inversion within the hyperfine levels of the 5s orbital of Rubidium is demonstrated for a single linearly polarized, linearly down chirped, laser pulse of nanosecond duration and beam intensity on the order of kWcm2 . Superpositions of equally populated hyperfine states, a phenomenon which is crucial in the development of qubits, were also observed for certain values of the field parameters. The results of this analysis are applicable to 85Rb and 87Rb and both the D1 and D2 transitions and are valid for the two models used. For the case of internal state cooling, the power spectrum of a standard pulse train was compared to that of a pulse with sinusoidal phase modulation revealing that the envelope of the frequency comb associated with such a pulse train is controllable via the phase modulation. Thus through frequency modulation the

  11. Auto-correlation function and frequency spectrum due to a super-position of uncorrelated exponential pulses

    NASA Astrophysics Data System (ADS)

    Garcia, O. E.; Theodorsen, A.

    2017-03-01

    The auto-correlation function and the frequency power spectral density due to a super-position of uncorrelated exponential pulses are considered. These are shown to be independent of the degree of pulse overlap and thereby the intermittency of the stochastic process. For constant pulse duration and a one-sided exponential pulse shape, the power spectral density has a Lorentzian shape which is flat for low frequencies and a power law at high frequencies. The algebraic tail is demonstrated to result from the discontinuity in the pulse function. For a strongly asymmetric two-sided exponential pulse shape, the frequency spectrum is a broken power law with two scaling regions. In the case of a symmetric pulse shape, the power spectral density is the square of a Lorentzian function. The steep algebraic tail at high frequencies in these cases is demonstrated to follow from the discontinuity in the derivative of the pulse function. A random distribution of pulse durations is shown to result in apparently longer correlation times but has no influence on the asymptotic power law tail of the frequency spectrum. The effect of additional random noise is also discussed, leading to a flat spectrum for high frequencies. The probability density function for the fluctuations is shown to be independent of the distribution of pulse durations. The predictions of this model describe the variety of auto-correlation functions and power spectral densities reported from experimental measurements in the scrape-off layer of magnetically confined plasmas.

  12. Mode selection and frequency tuning by injection in pulsed TEA-CO2 lasers

    NASA Technical Reports Server (NTRS)

    Flamant, P. H.; Menzies, R. T.

    1983-01-01

    An analytical model characterizing pulsed-TEA-CO2-laser injection locking by tunable CW-laser radiation is presented and used to explore the requirements for SLM pulse generation. Photon-density-rate equations describing the laser mechanism are analyzed in terms of the mode competition between photon densities emitted at two frequencies. The expression derived for pulsed dye lasers is extended to homogeneously broadened CO2 lasers, and locking time is defined as a function of laser parameters. The extent to which injected radiation can be detuned from the CO2 line center and continue to produce SLM pulses is investigated experimentally in terms of the analytical framework. The dependence of locking time on the detuning/pressure-broadened-halfwidth ratio is seen as important for spectroscopic applications requiring tuning within the TEA-laser line-gain bandwidth.

  13. Enhancement of proton acceleration by frequency-chirped laser pulse in radiation pressure mechanism

    NASA Astrophysics Data System (ADS)

    Vosoughian, H.; Riazi, Z.; Afarideh, H.; Yazdani, E.

    2015-07-01

    The transition from hole-boring to light-sail regime of radiation pressure acceleration by frequency-chirped laser pulses is studied using particle-in-cell simulation. The penetration depth of laser into the plasma with ramped density profile increases when a negatively chirped laser pulse is applied. Because of this induced transparency, the laser reflection layer moves deeper into the target and the hole-boring stage would smoothly transit into the light-sail stage. An optimum chirp parameter which satisfies the laser transparency condition, a 0 ≈ π n e l / n c λ , is obtained for each ramp scale length. Moreover, the efficiency of conversion of laser energy into the kinetic energy of particles is maximized at the obtained optimum condition. A relatively narrow proton energy spectrum with peak enhancement by a factor of 2 is achieved using a negatively chirped pulse compared with the un-chirped pulse.

  14. Single Frequency, Pulsed Laser Diode Transmitter for Dial Water Vapor Measurements at 935nm

    NASA Technical Reports Server (NTRS)

    Switzer, Gregg W.; Cornwell, Donald M., Jr.; Krainak, Michael A.; Abshire, James B.; Rall, Johnathan A. R.

    1998-01-01

    We report a tunable, single frequency, narrow linewidth, pulsed laser diode transmitter at 935.68nm for remote sensing of atmospheric water vapor. The transmitter consists of a CW, tunable, external cavity diode laser whose output is amplified 2OdB using a tapered diode amplifier. The output is pulsed for range resolved DIAL lidar by pulsing the drive current to the diode amplifier at 4kHz with a .5% duty cycle. The output from the transmitter is 36OnJ/pulse and is single spatial mode. It maintains a linewidth of less than 25MHz as its wavelength is tuned across the water vapor absorption line at 935.68nm. The transmitter design and its use in a water vapor measurement will be discussed.

  15. Measurement of complex ultrashort laser pulses using frequency-resolved optical gating

    NASA Astrophysics Data System (ADS)

    Xu, Lina

    This thesis contains three components of research: a detailed study of the performance of Frequency-Resolved Optical Gating (FROG) for measuring complex ultrashort laser pulses, a new method for measuring the arbitrary polarization state of an ultrashort laser pulse using Tomographic Ultrafast Retrieval of Transverse Light E-fields (TURTLE) technique, and new approach for measuring two complex pulses simultaneously using PG blind FROG. In recent decades, many techniques for measuring the full intensity and phase of ultrashort laser pulses have been proposed. These techniques include: Spectral Interferometry (SI)[1], Temporal Analysis by Dispersing a Pair of Light E-Field (TADPOLE)[2], Spectral Phase Interferometry for direct electric-field reconstruction (SPIDER)[3], and Frequency-Resolved Optical Gating (FROG)[4]. Each technique is actually a class of techniques that includes different variations on the original idea, such as SEA-SPIDER[5], ZAP SPIDER[6] are two variations of SPIDER. But most of these techniques for measuring ultrashort laser pulses either do not yield the complete time-dependent intensity and phase (e.g., autocorrelation), can at best only measure simple pulses (e.g., SPIDER), or need well characterized reference pulse. In this thesis, we compare the performance of three versions of FROG: second-harmonic-generation (SHG) FROG, polarization-gate (PG) FROG, and cross-correlation FROG (XFROG), the last of which requires a well-characterized reference pulse. We found that the XFROG algorithm converged in all cases and required only one initial guess. The PG FROG algorithm converged for 99% of the moderately complex pulses that we tried, and for over 95% of the most complex pulses (TBP ˜ 100). And the SHG FROG algorithm converged for 95% of the pulses that we tried and for over 80% of the most complex pulses. After some analysis, we found that noise filtering and adding more sampling points to the FROG trace solved the non-converging problems and we

  16. Enhanced electroporation in plant tissues via low frequency pulsed electric fields: influence of cytoplasmic streaming.

    PubMed

    Asavasanti, Suvaluk; Stroeve, Pieter; Barrett, Diane M; Jernstedt, Judith A; Ristenpart, William D

    2012-01-01

    Pulsed electric fields (PEF) are known to be effective at permeabilizing plant tissues. Prior research has demonstrated that lower pulse frequencies induce higher rates of permeabilization, but the underlying reason for this response is unclear. Intriguingly, recent microscopic observations with onion tissues have also revealed a correlation between PEF frequency and the subsequent speed of intracellular convective motion, i.e., cytoplasmic streaming. In this paper, we investigate the effect of cytoplasmic streaming on the efficacy of plant tissue permeabilization via PEF. Onion tissue samples were treated with Cytochalasin B, a known inhibitor of cytoplasmic streaming, and changes in cellular integrity and viability were measured over a wide range of frequencies and field strengths. We find that at low frequencies (f < 1 Hz), the absence of cytoplasmic streaming results in a 19% decrease in the conductivity disintegration index compared with control samples. Qualitatively, similar results were observed using a microscopic cell viability assay. The results suggest that at low frequencies convection plays a statistically significant role in distributing more conductive fluid throughout the tissue, making subsequent pulses more efficacious. The key practical implication is that PEF pretreatment at low frequency can increase the rate of tissue permeabilization in dehydration or extraction processes, and that the treatment will be most effective when cytoplasmic streaming is most active, i.e., with freshly prepared plant tissues.

  17. A nonlinearity-tolerant frequency domain root M-shaped pulse for coherent optical communication systems.

    PubMed

    Xu, Xian; Zhuge, Qunbi; Châtelain, Benoît; Morsy-Osman, Mohamed; Chagnon, Mathieu; Qiu, Meng; Plant, David V

    2013-12-30

    A new intersymbol interference (ISI)-free nonlinearity-tolerant frequency domain root M-shaped pulse (RMP) is derived for dispersion unmanaged coherent optical transmission systems. Beginning with the relationship between pulse shaping and intra-channel nonlinearity effects, we derive closed-form expressions for the proposed pulse. Experimental demonstrations reveal that by employing the proposed pulse at a roll-off factor of 1, the maximum transmission reach of a single-channel 56 Gb/s polarization-division-multiplexed quadrature phase-shift keying (PDM-QPSK) system can be extended by 33% and 17%, when compared to systems using a root raised cosine (RRC) pulse and a root optimized pulse (ROP), respectively. For a single-channel 128 Gb/s polarization-division-multiplexed 16-quadrature amplitude modulation (PDM-16QAM) system, the reach can be extended by 44% and 18%, respectively. Reach increases of 30% and 13% are also observed for a dense wavelength-division multiplexing (DWDM) 504 Gb/s PDM-QPSK transmission system. The tolerance to narrow filtering effect for the three pulses is experimentally studied as well.

  18. A time-dependent model of pulse-driven radio frequency capacitively coupled collisional plasma sheath

    NASA Astrophysics Data System (ADS)

    Rahman, M. T.; Hossain, M. Mofazzal

    2017-01-01

    The time-dependent model of ion motion is used to propose an analytical model for dual frequency (DF) capacitively coupled plasma (CCP) sheath driven by a pulsed source and a radio-frequency source. In this model, the sheath is considered to be collisional. In this model, the time dependent terms of ion fluid equations are ignored, but the electric field, ion motion and ion density remain time dependent. Electron profile is assumed to be step-like. Analytical expressions for electron sheath width and sheath potential have been developed. The calculated sheath width and potential are compared with the dual radio frequency driven time dependent models of capacitively coupled plasma sheath. From the temporal evaluation of sheath motion and potential, it has been found that pulse driven sheath has higher sheath potential and sheath width than that of conventional radio frequency driven DF CCP. Moreover, it is also found that ion energy spread can be reduced using pulsed power. From the temporal investigation of sheath motion and potential, it has been found that the duty cycle of the pulse power significantly affects sheath width and sheath potential.

  19. Development of an Ultra High Frequency Gyrotron with a Pulsed Magnet

    SciTech Connect

    Idehara, T.; Kamada, M.; Tsuchiya, H.; Hayashi, T.; Agusu, La; Mitsudo, S.; Ogawa, I.; Manuilov, V. N.; Naito, K.; Yuyama, T.; Jiang, W.; Yatsui, K.

    2006-01-03

    An ultra-high frequency gyrotron is being developed as a THz radiation source by using a pulsed magnet. We have achieved the highest field intensity of 20.2 T. High frequency operation at the second harmonic will achieve 1.01 THz; the corresponding cavity mode is TE6,11,1. On the other hand, an ultra-high power gyrotron with a pulsed magnet is also being developed as a millimeter to submillimeter wave radiation source. The gyrotron is a large orbit gyrotron (LOG) using an intense relativistic electron beam (IREB). A pulsed power generator 'ETIGO-IV' is applied for generation of the IREB. A prototype relativistic LOG was constructed for fundamental operation. The output of the LOG will achieve 144 GHz and 9 MW; the corresponding cavity mode is TE1,4,1. Cavities for 2nd and 4th harmonic operations were designed by numerical simulation for achievement of higher frequency. The progress of development for prototype high frequency gyrotrons with pulsed magnets is presented.

  20. Radio Frequency Heat Treatments to Disinfest Dried Pulses of Cowpea Weevil

    USDA-ARS?s Scientific Manuscript database

    To explore the potential of radio frequency (RF) heat treatments as an alternative to chemical fumigants for disinfestation of dried pulses, the relative heat tolerance and dielectric properties of different stages of the cowpea weevil (Callosobruchus maculatus) was determined. Among the immature st...

  1. Direct Measurement of Basilar Membrane Motion Using Pulsed-Wave Doppler High-Frequency Ultrasound

    NASA Astrophysics Data System (ADS)

    Torbatian, Z.; Garland, P.; Adamson, R. B. A.; Bance, M.; Brown, J. A.

    2011-11-01

    We present a preliminary report on the use of a new technique for measuring the motion of the basilar membrane, high-frequency ultrasound Doppler vibrometry. Using a custom-built, 1 mm diameter probe, we collected ultrasonic reflections from intracochlear structures and applied pulsed-wave Doppler vibrometry to measure the basilar membrane response to pressure applied in the ear canal.

  2. High frequency application of nanosecond pulsed electric fields alters cellular membrane disruption and fluorescent dye uptake

    NASA Astrophysics Data System (ADS)

    Steelman, Zachary A.; Tolstykh, Gleb P.; Beier, Hope T.; Ibey, Bennett L.

    2016-03-01

    Cells exposed to nanosecond-pulsed electric fields (nsPEF) exhibit a wide variety of nonspecific effects, including blebbing, swelling, intracellular calcium bursts, apoptotic and necrotic cell death, formation of nanopores, and depletion of phosphatidylinositol 4,5-biphosphate (PIP2) to induce activation of the inositol trisphosphate/diacylglycerol pathway. While several studies have taken place in which multiple pulses were delivered to cells, the effect of pulse repetition rate (PRR) is not well understood. To better understand the effects of PRR, a laser scanning confocal microscope was used to observe CHO-K1 cells exposed to ten 600ns, 200V pulses at varying repetition rates (5Hz up to 500KHz) in the presence of either FM 1-43, YO-PRO-1, or Propidium Iodide (PI) fluorescent dyes, probes frequently used to indicate nanoporation or permeabilization of the plasma membrane. Dye uptake was monitored for 30 seconds after pulse application at a rate of 1 image/second. In addition, a single long pulse of equivalent energy (200V, 6 μs duration) was applied to test the hypothesis that very fast PRR will approximate the biological effects of a single long pulse of equal energy. Upon examination of the data, we found strong variation in the relationship between PRR and uptake in each of the three dyes. In particular, PI uptake showed little frequency dependence, FM 1-43 showed a strong inverse relationship between frequency and internal cell fluorescence, and YO-PRO-1 exhibited a "threshold" point of around 50 KHz, after which the inverse trend observed in FM 1-43 was seen to reverse itself. Further, a very high PRR of 500 KHz only approximated the biological effects of a single 6 μs pulse in cells stained with YO-PRO-1, suggesting that uptake of different dyes may proceed by different physical mechanisms.

  3. Calcium homeostasis of isolated heart muscle cells exposed to pulsed high-frequency electromagnetic fields

    SciTech Connect

    Wolke, S.; Gollnick, F.; Meyer, R.; Neibig, U.; Elsner, R.

    1996-05-01

    The intracellular calcium concentration ([Ca{sup 2+}]{sub i}) of isolated ventricular cardiac myocytes of the guinea pig was measured during the application of pulsed high-frequency electromagnetic fields. The high-frequency fields were applied in a transverse electromagnetic cell designed to allow microscopic observation of the myocytes during the presence of the high-frequency fields. The [Ca{sup 2+}]{sub i} was measured as fura-2 fluorescence by means of digital image analysis. Both the carrier frequency and the square-wave pulse-modulation pattern were varied during the experiments (carrier frequencies: 900, 1,300, and 1,800 MHz pulse modulated at 217 Hz with 14% duty cycle; pulsation pattern at 900 MHz; continuous wave, 16 Hz,and 50 Hz modulation with 50% duty cycle and 30 kHz modulation with 80% duty cycle). The mean specific absorption rate (SAR) values in the solution were within one order of magnitude of 1 mW/kg. They varied depending on the applied carrier frequency and pulse pattern. The experiments were designed in three phases: 500 s of sham exposure, followed by 500 s of field exposure, then chemical stimulation without field. The chemical stimulation (K{sup +}-depolarization) indicated the viability of the cells. The K{sup +} depolarization yielded a significant increase in [Ca{sup 2+}]{sub i}. Significant differences between sham exposure and high-frequency field exposure were not found except when a very small but statistically significant difference was detected in the case of 900 MHz/50 Hz. However, this small difference was not regarded as a relevant effect of the exposure.

  4. Dynamics of frequency-modulated soliton-like pulses in a longitudinally inhomogeneous, anomalous group velocity dispersion fibre amplifier

    SciTech Connect

    Zolotovskii, Igor' O; Korobko, D A; Okhotnikov, Oleg G; Sysolyatin, A A; Fotiadi, A A

    2012-09-30

    We examine conditions for the formation and amplification of frequency-modulated soliton-like pulses in longitudinally inhomogeneous, anomalous group velocity dispersion fibres. The group velocity dispersion profiles necessary for the existence and amplification of such pulses in active fibres are identified and the pulse duration and chirp are determined as functions of propagation distance. (optical fibres, lasers and amplifiers. properties and applications)

  5. Structural, mechanical and optical properties of nitrogen-implanted titanium at different pulse frequency

    NASA Astrophysics Data System (ADS)

    Raaif, Mohamed; Mohamed, Sodky H.; Abd El-Rahman, Ahmed M.; Kolitsch, Andreas

    2013-04-01

    Plasma-immersion ion implantation (PIII) is a potent method to obtain hard and wear-resistant surface on Ti by nitrogen implantation. This presentation is one part of a sequence of experiments to optimize the microstructure and physical properties of TiN through adapting the plasma-processing parameters. In this work, nitrogen ions were implanted into samples of pure Ti at different nitrogen pulse frequency without using any external source of heating. The nitrogen-implanted surfaces were characterized by X-ray diffraction (XRD), Auger electron spectroscopy (AES), optical microscope, nano-indentation technique, ball-on-disk type tribometer, surface profilemeter, Tafel polarization technique for corrosion performance and ellipsometry. The outcomes show that, nitrogen PIII is an effectual method for nitriding titanium and nitrogen pulse frequency affected the microstructure and physical properties of the treated Ti. X-ray diffraction depicted the formation of α-Ti (N) and the cubic TiN after implanting titanium by nitrogen and the thickness of the nitrided layer increased as the nitrogen pulse frequency increased. The wear and corrosion resistance of the nitrogen-implanted titanium are improved and the friction coefficient decreased from nearly 0.8 for the un-implanted titanium to 0.3 for the implanted titanium, this ascribed to the formation of the titanium nitrided phases. Ellipsometric measurements were carried out on the PIII titanium samples at different nitrogen pulse frequency. The ellipsometric measurements show that, the thickness of the nitrided layer and surface roughness increased while the refractive index decreased with increasing nitrogen pulse frequency.

  6. Elimination of the light shift in rubidium gas cell frequency standards using pulsed optical pumping

    NASA Technical Reports Server (NTRS)

    English, T. C.; Jechart, E.; Kwon, T. M.

    1978-01-01

    Changes in the intensity of the light source in an optically pumped, rubidium, gas cell frequency standard can produce corresponding frequency shifts, with possible adverse effects on the long-term frequency stability. A pulsed optical pumping apparatus was constructed with the intent of investigating the frequency stability in the absence of light shifts. Contrary to original expectations, a small residual frequency shift due to changes in light intensity was experimentally observed. Evidence is given which indicates that this is not a true light-shift effect. Preliminary measurements of the frequency stability of this apparatus, with this small residual pseudo light shift present, are presented. It is shown that this pseudo light shift can be eliminated by using a more homogeneous C-field. This is consistent with the idea that the pseudo light shift is due to inhomogeneity in the physics package (position-shift effect).

  7. Higher-order modulations of fs laser pulses for GHz frequency domain photon migration system.

    PubMed

    Lin, Huang-Yi; Cheng, Nanyu; Tseng, Sheng-Hao; Chan, Ming-Che

    2014-02-24

    Except the fundamental modulation frequency, by higher-order-harmonic modulations of mode-locked laser pulses and a simple frequency demodulation circuit, a novel approach to GHz frequency-domain-photon-migration (FDPM) system was reported. With this novel approach, a wide-band modulation frequency comb is available without any external modulation devices and the only electronics to extract the optical attenuation and phase properties at a selected modulation frequency in FDPM systems are good mixers and lock-in devices. This approach greatly expands the frequency range that could be achieved by conventional FDPM systems and suggests that our system could extract much more information from biological tissues than the conventional FDPM systems. Moreover, this demonstration will be beneficial for discerning the minute change of tissue properties.

  8. Pressure and Thrust Measurements of a High-Frequency Pulsed Detonation Tube

    NASA Technical Reports Server (NTRS)

    Nguyen, N.; Cutler, A. D.

    2008-01-01

    This paper describes measurements of a small-scale, high-frequency pulsed detonation tube. The device utilized a mixture of H2 fuel and air, which was injected into the device at frequencies of up to 1200 Hz. Pulsed detonations were demonstrated in an 8-inch long combustion volume, at about 600 Hz, for the quarter wave mode of resonance. The primary objective of this experiment was to measure the generated thrust. A mean value of thrust was measured up to 6.0 lb, corresponding to H2 flow based specific impulse of 2970 s. This value is comparable to measurements in H2-fueled pulsed detonation engines (PDEs). The injection and detonation frequency for this new experimental case was much higher than typical PDEs, where frequencies are usually less than 100 Hz. The compact size of the device and high frequency of detonation yields a thrust-per-unit-volume of approximately 2.0 pounds per cubic inch, and compares favorably with other experiments, which typically have thrust-per-unit-volume of order 0.01 pound per cubic inch. This much higher volumetric efficiency results in a potentially much more practical device than the typical PDE, for a wide range of potential applications, including high-speed boundary layer separation control, for example in hypersonic engine inlets, and propulsion for small aircraft and missiles.

  9. Pressure and Thrust Measurements of a High-Frequency Pulsed-Detonation Actuator

    NASA Technical Reports Server (NTRS)

    Nguyen, Namtran C.; Cutler, Andrew D.

    2008-01-01

    This paper describes the development of a small-scale, high-frequency pulsed detonation actuator. The device utilized a fuel mixture of H2 and air, which was injected into the device at frequencies of up to 1200 Hz. Pulsed detonations were demonstrated in an 8-inch long combustion volume, at approx.600 Hz, for the lambda/4 mode. The primary objective of this experiment was to measure the generated thrust. A mean value of thrust was measured up to 6.0 lb, corresponding to specific impulse of 2611 s. This value is comparable to other H2-fueled pulsed detonation engines (PDEs) experiments. The injection and detonation frequency for this new experimental case was approx.600 Hz, and was much higher than typical PDEs, where frequencies are usually less than 100 Hz. The compact size of the model and high frequency of detonation yields a thrust-per-unit-volume of approximately 2.0 lb/cu in, and compares favorably with other experiments, which typically have thrust-per-unit-volume values of approximately 0.01 lb/cu in.

  10. Pulse-to-pulse alignment based on interference fringes and the second-order temporal coherence function of optical frequency combs for distance measurement.

    PubMed

    Zhu, Jigui; Cui, Pengfei; Guo, Yin; Yang, Linghui; Lin, Jiarui

    2015-05-18

    A pulse-to-pulse alignment method based on interference fringes and the second-order temporal coherence function of optical frequency combs is proposed for absolute distance measurement. The second-order temporal coherence function of the pulse train emitted from optical frequency combs is studied. A numerical model of the function is developed with an assumption of Gaussian pulse and has good agreement with experimental measurements taken by an ordinary Michelson interferometer. The experimental results show an improvement of standard deviation of peak finding results from 27.3 nm to 8.5 nm by the method in ordinary laboratory conditions. The absolute distance measurement with the pulse-to-pulse alignment method is also proposed and experimentally proved.

  11. Transportation decreases the pulse frequency of growth hormone in the blood of prepubertal male calves.

    PubMed

    Kadokawa, Hiroya; Noguchi, Koutarou; Hajiri, Yuuki; Takeshita, Kazuhisa; Fujii, Youichi

    2013-01-01

    Both the mean concentration and the pulse pattern of growth hormone (GH) in the blood are important for the metabolism and body growth of calves. Transportation is reported to decrease blood GH concentrations in prepubertal male calves. However, the effect of transportation on GH pulsatility remains unknown. Because transportation is important in moving these calves from calf-production farms to markets or fattening farms, we tested whether transportation decreases their GH pulse frequency. Five calves were subjected to transportation by trucking (transport group), while five were left in their shed (non-transport group). Both groups were subsequently subjected to frequent blood sampling at 15-min intervals for 5 h. In the transport group, the cortisol concentrations increased in the first hour (P < 0.05) but significantly decreased thereafter (P < 0.05) to lower than those of the non-transport group. During the 5-hour study period, the transport group displayed a similar mean GH concentration relative to the non-transport group, but displayed a delayed first GH pulse, and a lower number of GH pulses than the non-transport group (P < 0.05). Hence, transportation is suggested to decrease GH pulse frequency under abnormal cortisol states, presumably suppressing metabolism and body growth in prepubertal male calves.

  12. Circularly polarized harmonic generation by intense bicircular laser pulses: electron recollision dynamics and frequency dependent helicity

    NASA Astrophysics Data System (ADS)

    Bandrauk, André D.; Mauger, François; Yuan, Kai-Jun

    2016-12-01

    Numerical solutions of time-dependent Schrödinger equations for one and two electron cyclic molecules {{{H}}}nq+ exposed to intense bichromatic circularly polarized laser pulses of frequencies {ω }1 and {ω }2, such that {ω }1/{ω }2={n}1/{n}2 (integer) produce circularly polarized high order harmonics with a cut-off recollision maximum energy at and greater than the linear polarization law (in atomic units) {N}m{ω }1={I}p+3.17{U}p, where I p is the ionization potential and {U}p={(2{E}0)}2/4{ω }2 is the ponderomotive energy defined by the field E 0 (intensity I={{cE}}02/8π ) from each pulse and mean frequency ω =({ω }1+{ω }2)/2 . An electron recollision model in a rotating frame at rotating frequency {{Δ }}ω =({ω }1-{ω }2)/2 predicts this simple result as a result of recollision dynamics in a combination of bichromatic circularly polarized pulses. The harmonic helicities and their intensities are shown to depend on compatible symmetries of the net pulse electric fields with that of the molecules.

  13. Study on technology of high-frequency pulsed magnetic field strength measurement.

    PubMed

    Chen, Yi-Mei; Liu, Zhi-Peng; Yin, Tao

    2012-01-01

    High-frequency transient weak magnetic field is always involved in researches about biomedical engineering field while common magnetic-field sensors cannot work properly at frequencies as high as MHz. To measure the value of MHz-level weak pulsed magnetic-field strength accurately, this paper designs a measurement and calibration method for pulsed magnetic-field. In this paper, a device made of Nonferromagnetic material was independently designed and applied to pulsed magnetic field measurement. It held an accurately relative position between the magnetic field generating coil and the detecting coil. By applying a sinusoidal pulse to the generator, collecting the induced electromotive force of the detector, the final magnetic field strength was worked out through algorithms written in Matlab according to Faraday's Law. Experiments were carried out for measurement and calibration. Experiments showed that, under good stability and consistency, accurate measurement of magnetic-field strength of a sinepulse magnetic-field can be achieved, with frequency at 0.5, 1, 1.5 MHz and strength level at micro-Tesla. Calibration results carried out a measuring relative error about 2.5%.

  14. Phase and frequency structure of superradiance pulses generated by relativistic Ka-band backward-wave oscillator

    SciTech Connect

    Rostov, V. V.; Romanchenko, I. V.; Elchaninov, A. A.; Sharypov, K. A.; Shunailov, S. A.; Ul'masculov, M. R.; Yalandin, M. I.

    2016-08-15

    Phase and frequency stability of electromagnetic oscillations in sub-gigawatt superradiance (SR) pulses generated by an extensive slow-wave structure of a relativistic Ka-band backward-wave oscillator were experimentally investigated. Data on the frequency tuning and radiation phase stability of SR pulses with a variation of the energy and current of electron beam were obtained.

  15. Wavelength conversion through soliton self-frequency shift in tellurite microstructured fiber with picosecond pump pulse

    NASA Astrophysics Data System (ADS)

    Bi, Wanjun; Li, Xia; Xing, Zhaojun; Zhou, Qinling; Fang, Yongzheng; Gao, Weiqing; Xiong, Liangming; Hu, Lili; Liao, Meisong

    2016-01-01

    Wavelength conversion to the wavelength range that is not covered by commercially available lasers could be accomplished through the soliton self-frequency shift (SSFS) effect. In this study, the phenomenon of SSFS pumped by a picosecond-order pulse in a tellurite microstructured fiber is investigated both theoretically and experimentally. The balance between the dispersion and the nonlinearity achieved by a 1958 nm pump laser induces a distinct SSFS effect. Attributed to the large spectral distance between the pump pulse and the fiber zero-dispersion wavelength, the SSFS is not cancelled due to energy shedding from the soliton to the dispersive wave. Details about the physical mechanisms behind this phenomenon and the variations of the wavelength shift, the conversion efficiency are revealed based on numerical simulations. Owing to the large soliton number N, the pulse width of the first split fundamental soliton is approximately 40 fs, producing a pulse compression factor of ˜38, much higher than that pumped by a femtosecond pulse. Experiments were also conducted to confirm the validity of the simulation results. By varying the pump power, a continuous soliton shift from 1990 nm to 2264 nm was generated. The generation of SSFS in tellurite microstructured fibers with picosecond pump pulse can provide a new approach for wavelength conversion in the mid-infrared range and could be useful in medical and some other areas.

  16. Spectrographic phase-retrieval algorithm for femtosecond and attosecond pulses with frequency gaps

    NASA Astrophysics Data System (ADS)

    Seifert, B.; Wallentowitz, S.; Volkmann, U.; Hause, A.; Sperlich, K.; Stolz, H.

    2014-10-01

    We present a phase-reconstruction algorithm for a self-referenced spectrographic pulse characterization technique called “very advanced method for phase and intensity retrieval of e-fields” (VAMPIRE). This technique permits a spectral phase reconstruction of pulses with separated frequency components. The algorithm uses the particular characteristics of VAMPIRE spectrograms. It is a locally structured algorithm which is fast, robust, and it allows us to master stagnation problems. The algorithm is tested by use of both simulated and measured data.

  17. Injection seeded single-frequency pulsed Nd:YAG laser resonated by an intracavity phase modulator.

    PubMed

    Zhang, Junxuan; Zhu, Xiaolei; Zang, Huaguo; Ma, Xiuhua; Yin, Suyong; Li, Shiguang; Chen, Weibiao

    2014-11-01

    A reliable single frequency Q-switched Nd:YAG laser is developed by using a lithium niobate crystal as the intracavity phase modulator. Successful injection seeding is performed by adopting an electro-optic crystal in an effectively simplified cavity arrangement. The laser is capable of producing 4.8 mJ pulse-energy at 400 Hz repetition rate with nearly Fourier-transform-limited spectral linewidth. The pulse duration is approximately 25 ns, and the beam quality factor M2 is less than 1.3.

  18. Ion-molecule collision frequencies in gases determined by phase coherent pulsed ICR.

    NASA Technical Reports Server (NTRS)

    Lieder, C. A.; Wien, R. W.; Mciver, R. T., Jr.

    1972-01-01

    The transient method considered is analogous to similar phase coherence experiments performed in NMR and plasma physics. Using a pulsed ion cyclotron resonance (ICR) spectrometer equipped with a trapped ion analyzer cell, gaseous ions are formed by a pulse of an electron beam and then trapped in the cell by the combined effects of the magnetic and electrostatic fields. The results obtained in the experiments indicate that the classical mobility treatment of Wannier (1953) is helpful in the understanding of collision frequencies under the considered conditions.

  19. Mitigation of impedance changes due to electroporation therapy using bursts of high-frequency bipolar pulses

    PubMed Central

    2015-01-01

    Background For electroporation-based therapies, accurate modeling of the electric field distribution within the target tissue is important for predicting the treatment volume. In response to conventional, unipolar pulses, the electrical impedance of a tissue varies as a function of the local electric field, leading to a redistribution of the field. These dynamic impedance changes, which depend on the tissue type and the applied electric field, need to be quantified a priori, making mathematical modeling complicated. Here, it is shown that the impedance changes during high-frequency, bipolar electroporation therapy are reduced, and the electric field distribution can be approximated using the analytical solution to Laplace's equation that is valid for a homogeneous medium of constant conductivity. Methods Two methods were used to examine the agreement between the analytical solution to Laplace's equation and the electric fields generated by 100 µs unipolar pulses and bursts of 1 µs bipolar pulses. First, pulses were applied to potato tuber tissue while an infrared camera was used to monitor the temperature distribution in real-time as a corollary to the electric field distribution. The analytical solution was overlaid on the thermal images for a qualitative assessment of the electric fields. Second, potato ablations were performed and the lesion size was measured along the x- and y-axes. These values were compared to the analytical solution to quantify its ability to predict treatment outcomes. To analyze the dynamic impedance changes due to electroporation at different frequencies, electrical impedance measurements (1 Hz to 1 MHz) were made before and after the treatment of potato tissue. Results For high-frequency bipolar burst treatment, the thermal images closely mirrored the constant electric field contours. The potato tissue lesions differed from the analytical solution by 39.7 ± 1.3 % (x-axis) and 6.87 ± 6.26 % (y-axis) for conventional unipolar pulses

  20. Mitigation of impedance changes due to electroporation therapy using bursts of high-frequency bipolar pulses.

    PubMed

    Bhonsle, Suyashree P; Arena, Christopher B; Sweeney, Daniel C; Davalos, Rafael V

    2015-01-01

    For electroporation-based therapies, accurate modeling of the electric field distribution within the target tissue is important for predicting the treatment volume. In response to conventional, unipolar pulses, the electrical impedance of a tissue varies as a function of the local electric field, leading to a redistribution of the field. These dynamic impedance changes, which depend on the tissue type and the applied electric field, need to be quantified a priori, making mathematical modeling complicated. Here, it is shown that the impedance changes during high-frequency, bipolar electroporation therapy are reduced, and the electric field distribution can be approximated using the analytical solution to Laplace's equation that is valid for a homogeneous medium of constant conductivity. Two methods were used to examine the agreement between the analytical solution to Laplace's equation and the electric fields generated by 100 µs unipolar pulses and bursts of 1 µs bipolar pulses. First, pulses were applied to potato tuber tissue while an infrared camera was used to monitor the temperature distribution in real-time as a corollary to the electric field distribution. The analytical solution was overlaid on the thermal images for a qualitative assessment of the electric fields. Second, potato ablations were performed and the lesion size was measured along the x- and y-axes. These values were compared to the analytical solution to quantify its ability to predict treatment outcomes. To analyze the dynamic impedance changes due to electroporation at different frequencies, electrical impedance measurements (1 Hz to 1 MHz) were made before and after the treatment of potato tissue. For high-frequency bipolar burst treatment, the thermal images closely mirrored the constant electric field contours. The potato tissue lesions differed from the analytical solution by 39.7 ± 1.3 % (x-axis) and 6.87 ± 6.26 % (y-axis) for conventional unipolar pulses, and 15.46 ± 1.37 % (x

  1. The effect of high voltage, high frequency pulsed electric field on slain ovine cortical bone.

    PubMed

    Asgarifar, Hajarossadat; Oloyede, Adekunle; Zare, Firuz

    2014-04-01

    High power, high frequency pulsed electric fields known as pulsed power (PP) has been applied recently in biology and medicine. However, little attention has been paid to investigate the application of pulse power in musculoskeletal system and its possible effect on functional behavior and biomechanical properties of bone tissue. This paper presents the first research investigating whether or not PP can be applied safely on bone tissue as a stimuli and what will be the possible effect of these signals on the characteristics of cortical bone by comparing the mechanical properties of this type of bone pre and post expose to PP and in comparison with the control samples. A positive buck-boost converter was applied to generate adjustable high voltage, high frequency pulses (up to 500 V and 10 kHz). The functional behavior of bone in response to pulse power excitation was elucidated by applying compressive loading until failure. The stiffness, failure stress (strength) and the total fracture energy (bone toughness) were determined as a measure of the main bone characteristics. Furthermore, an ultrasonic technique was applied to determine and comprise bone elasticity before and after pulse power stimulation. The elastic property of cortical bone samples appeared to remain unchanged following exposure to pulse power excitation for all three orthogonal directions obtained from ultrasonic technique and similarly from the compression test. Nevertheless, the compressive strength and toughness of bone samples were increased when they were exposed to 66 h of high power pulsed electromagnetic field compared to the control samples. As the toughness and the strength of the cortical bone tissue are directly associated with the quality and integrity of the collagen matrix whereas its stiffness is primarily related to bone mineral content these overall results may address that although, the pulse power stimulation can influence the arrangement or the quality of the collagen network

  2. Building a Pulse Detector using the Frequency Resolved Optical Gating Technique

    SciTech Connect

    Vallin, J

    2004-02-05

    We show how to construct a diagnostic optical layout known as Frequency Resolved Optical Gating (FROG) for an ir mode-locked laser by using the nonlinear effect known as second harmonic generation (SHG). In this paper, we explain the principle of operation and the theory upon which this diagnostic is based. Moreover, we described the procedure used to measure the duration and frequency components of a pulse. This process consists of calibrating the scales of a two-dimensional image, time delay vs. frequency, known as FROG spectrogram or FROG trace. This calibration of the time delay scale yields the correspondence between a pixel and time delay. Similarly, the calibration of the frequency scale yields the correspondence between a pixel, and frequency.

  3. Increased efficiency of ion acceleration by using femtosecond laser pulses at higher harmonic frequency

    SciTech Connect

    Psikal, J.; Klimo, O.; Weber, S.; Margarone, D.

    2014-07-15

    The influence of laser frequency on laser-driven ion acceleration is investigated by means of two-dimensional particle-in-cell simulations. When ultrashort intense laser pulse at higher harmonic frequency irradiates a thin solid foil, the target may become re lativistically transparent for significantly lower laser pulse intensity compared with irradiation at fundamental laser frequency. The relativistically induced transparency results in an enhanced heating of hot electrons as well as increased maximum energies of accelerated ions and their numbers. Our simulation results have shown the increase in maximum proton energy and increase in the number of high-energy protons by a factor of 2 after the interaction of an ultrashort laser pulse of maximum intensity 7 × 10{sup 21 }W/cm{sup 2} with a fully ionized plastic foil of realistic density and of optimal thickness between 100 nm and 200 nm when switching from the fundamental frequency to the third harmonics.

  4. Assessment of a three-frequency alternate pulse Doppler wind lidar

    NASA Astrophysics Data System (ADS)

    Wu, Song-hua; Qin, Sheng-guang; Liu, Bingyi; Chen, Yang

    2011-06-01

    Incoherent Doppler wind lidar measures the wind by detecting the frequency shift of the laser backscattering from aerosol and atmosphere molecules. The wind measurement sensitivity of edge detection technology like iodine vapor filter depends on the aerosol load of probe volume. The current Direct detect wind lidar system has to obtain the measurement sensitivity from the independent measurement or prior atmosphere aerosol data before accurate wind retrieval. Otherwise, the variation of aerosol mixing ratio would introduce great uncertainty in the wind speed measurement, which is unacceptable on airborne and space-borne Doppler lidar. This paper proposes a new method to achieve real-time wind speed calibration by three adjacent frequency laser pulses alternately transmitted. Three laser pulses are frequency locked to the middle and two wings of the iodine filter absorption line. Because the frequency of triple pulses is changing rather fast, it can be approximately regarded as a synchronous measurement of both aerosol mixing ratio and wind speed. By this way, we can not only ensure the wind measure accuracy, but also achieve the reliable wind field measurement on a mobile platform.

  5. Holographic frequency resolved optical gating for spatio-temporal characterization of ultrashort optical pulse

    NASA Astrophysics Data System (ADS)

    Mehta, Nikhil; Yang, Chuan; Xu, Yong; Liu, Zhiwen

    2014-09-01

    We introduce a novel method for characterizing the spatio-temporal evolution of ultrashort optical field by recording the spectral hologram of frequency resolved optical gating (FROG) trace. We show that FROG holography enables the measurement of phase (up to an overall constant) and group delay of the pulse which cannot be measured by conventional FROG method. To illustrate our method, we perform numerical simulation to generate holographic collinear FROG (cFROG) trace of a chirped optical pulse and retrieve its complex profile at multiple locations as it propagates through a hypothetical dispersive medium. Further, we experimentally demonstrate our method by retrieving a 67 fs pulse at three axial locations in the vicinity of focus of an objective lens and compute its group delay.

  6. Generation of femtosecond UV pulses by intracavity frequency doubling in a modelocked dye laser

    NASA Astrophysics Data System (ADS)

    Laermer, F.; Dobler, J.; Elsaesser, T.

    1988-06-01

    A colliding pulse modelocked (CPM) dye laser is presented, which contains a nonlinear KDP crystal for frequency conversion inside the ring resonator. The laser system emits femtosecond light pulses simultaneously at wavelenghts of 628 nm and 314 nm with a repetition rate of 80 MHz. The output power at 628 nm and 314 nm amounts to 4 mW and 1 mW, respectively. The duration of the red and the uv pulses has a value of approximately 120 fs. The light source is used in femtosecond pump-and-probe investigations. The kinetics of excited state adsorption and ground state bleaching of laser dyes is measured. The temporal resolution of the experiments is better than 40 fs.

  7. An overview of DREV's activities on pulsed CO2 laser transmitters: Frequency stability and lifetime aspects

    NASA Technical Reports Server (NTRS)

    Cruickshank, James; Pace, Paul; Mathieu, Pierre

    1987-01-01

    After introducing the desired features in a transmitter for laser radar applications, the output characteristics of several configurations of frequency-stable TEA-CO2 lasers are reviewed. Based on work carried out at the Defence Research Establishment Valcartier (DREV), output pulses are examined from short cavity lasers, CW-TEA hybrid lasers, and amplifiers for low power pulses. It is concluded that the technique of injecting a low-power laser beam into a TEA laser resonator with Gaussian reflectivity mirrors should be investigated because it appears well adapted to producing high energy, single mode, low chirp pulses. Finally, a brief report on tests carried out on catalysts composed of stannic oxide and noble metals demonstrates the potential of these catalysts, operating at close to room temperature, to provide complete closed-cycle laser operation.

  8. Application of pulse frequency modulation photosensors to subretinal artificial retina implantation

    NASA Astrophysics Data System (ADS)

    Kagawa, Keiichiro; Yoshida, Norikatsu; Furumiya, Tetsuo; Ohta, Jun; Nunoshita, Masahiro

    2001-10-01

    In this paper we discuss an application of CMOS photo-sensor array chip using pulse frequency modulation (PFM) to sub-retinal implantation to recover human vision. PFM with integration mode as photo-sensing circuit is used to realize enough dynamic range and compatibility with signals in real retina. To effectively stimulate the retinal cells, we have designed a PFM circuit with limited bandwidth of output pulses and two kinds of pulse shaping circuits with digital waveform memory and pixel-level output amplitude tuner. We have fabricated a PFM photo-sensing test circuits with a standard 0.35 micrometers CMOS technology to measure its basic characteristics, and have demonstrated a large dynamic range of around 40 dB.

  9. Efficient frequency doubling of femtosecond pulses with BIBO in an external synchronized cavity

    NASA Astrophysics Data System (ADS)

    Kanseri, Bhaskar; Bouillard, Martin; Tualle-Brouri, Rosa

    2016-12-01

    We experimentally demonstrate the second harmonic generation (SHG) of infrared femtosecond pulses using a BIBO crystal placed in an external ring cavity, synchronized with an input mode-locked laser at 78 MHz. A frequency doubling efficiency of 53% is achieved which is, to the best of our knowledge, the highest value ever reported for a low energy input beam of 1.4 nJ/pulse. Theoretical analysis of cavity related issues such as design, fundamental mode characteristics and fidelity against misalignments are also presented. The modeling of SHG cavity enables us to estimate the cavity losses and the mode matching visibility. Such synchronized SHG cavities in pulse domain, having higher SHG conversion efficiencies compared to their continuous wave counterparts, may find potential applications in scientific areas such as in photonics, and in quantum optics.

  10. The Influence of Pulsed Electroplating Frequency and Duty Cycle on Copper Film Microstructure and Stress State.

    PubMed

    Marro, James B; Darroudi, Taghi; Okoro, Chukwudi A; Obeng, Yaw S; Richardson, Kathleen C

    2017-01-01

    In this work we studied the impact of pulse electroplating parameters on the cross-sectional and surface microstructures of blanket copper films using electron backscattering diffraction and x-ray diffraction. The films evaluated were highly (111) textured in the direction perpendicular to the film surface. The degree of preferential orientation was found to decrease with longer pulse on-times, due to strain energy driven growth of other grain orientations. Residual biaxial stresses were also measured in the films and higher pulse frequencies during deposition led to smaller biaxial stresses in the films. Film stress was also found to correlate with the amount of twinning in the copper film cross-sections. This has been attributed to the twins' thermal stability and mechanical properties.

  11. Generation of Alfven waves by high power pulse at the electron plasma frequency

    NASA Astrophysics Data System (ADS)

    van Compernolle, Bart Gilbert

    The physics of the interaction between plasmas and high power waves with frequencies in the electron plasma frequency range is of importance in many areas of space and plasma physics. A great deal of laboratory research has been done on the interaction of microwaves in a density gradient when o = ope in unmagnetized plasmas. [SWK74, WS78, KSW74]. Extensive studies of HF-ionospheric modifications have been performed [Fej79] as evidenced by experiments at Arecibo [HMD92, BHK86, CDF92, FGI85], at the HAARP facility [RKK98] in Alaska, at the EISCAT observatory in Norway [IHR99], and at SURA in Russia [FKS99]. This dissertation focusses on the interaction with a fully magnetized plasma, capable of supporting Alfven waves. The experiment is performed in the upgraded LArge Plasma Device (LAPD) at UCLA [GPL91] (Helium, n = 1012 cm-3, B = 1 kG - 2.5 kG). A number of experiments have been done at LAPD using antennas, skin depth scale currents and laser produced plasmas to generate Alfven waves [LGM99, GVL97a, GVL97b, VGV01]. In this work a high power pulse 6th, frequency in the electron plasma frequency range is launched into the radial density gradient, perpendicular to the background magnetic field. The microwave pulses last on the order of one ion gyro period and has a maximum power of |E|2/ nT ≃ .5 in the afterglow. The absorption of these waves leads to a pulse of field aligned suprathermal electrons. This electron current pulse then launches with Alfven wave with o ≤ o ci. The experiment was performed bath in ordinary node (O-mode) and extraordinary (X-mode), for different background magnetic fields B0, different temperatures (afterglow vs discharge) and different power levels of the incoming microwaves. It was found that the Alfven wave generation can be explained by Cherenkov radiation of Alfven waves by the suprathermal electron pulse. Theoretical solutions for the perturbed magnetic field due to a pulse of field aligned electrons were obtained, and shown to be

  12. Pulsing frequency induced change in optical constants and dispersion energy parameters of WO3 films grown by pulsed direct current magnetron sputtering

    NASA Astrophysics Data System (ADS)

    Punitha, K.; Sivakumar, R.; Sanjeeviraja, C.

    2014-03-01

    In this work, we present the pulsing frequency induced change in the structural, optical, vibrational, and luminescence properties of tungsten oxide (WO3) thin films deposited on microscopic glass and fluorine doped tin oxide (SnO2:F) coated glass substrates by pulsed dc magnetron sputtering technique. The WO3 films deposited on SnO2:F substrate belongs to monoclinic phase. The pulsing frequency has a significant influence on the preferred orientation and crystallinity of WO3 film. The maximum optical transmittance of 85% was observed for the film and the slight shift in transmission threshold towards higher wavelength region with increasing pulsing frequency revealed the systematic reduction in optical energy band gap (3.78 to 3.13 eV) of the films. The refractive index (n) of films are found to decrease (1.832 to 1.333 at 550 nm) with increasing pulsing frequency and the average value of extinction coefficient (k) is in the order of 10-3. It was observed that the dispersion data obeyed the single oscillator of the Wemple-Didomenico model, from which the dispersion energy (Ed) parameters, dielectric constants, plasma frequency, oscillator strength, and oscillator energy (Eo) of WO3 films were calculated and reported for the first time due to variation in pulsing frequency during deposition by pulsed dc magnetron sputtering. The Eo is change between 6.30 and 3.88 eV, while the Ed varies from 25.81 to 7.88 eV, with pulsing frequency. The Raman peak observed at 1095 cm-1 attributes the presence of W-O symmetric stretching vibration. The slight shift in photoluminescence band is attributed to the difference in excitons transition. We have made an attempt to discuss and correlate these results with the light of possible mechanisms underlying the phenomena.

  13. Rising nutrient-pulse frequency and high UVR strengthen microbial interactions

    PubMed Central

    Cabrerizo, Marco J.; Medina-Sánchez, Juan Manuel; Dorado-García, Irene; Villar-Argaiz, Manuel; Carrillo, Presentación

    2017-01-01

    Solar radiation and nutrient pulses regulate the ecosystem’s functioning. However, little is known about how a greater frequency of pulsed nutrients under high ultraviolet radiation (UVR) levels, as expected in the near future, could alter the responses and interaction between primary producers and decomposers. In this report, we demonstrate through a mesocosm study in lake La Caldera (Spain) that a repeated (press) compared to a one-time (pulse) schedule under UVR prompted higher increases in primary (PP) than in bacterial production (BP) coupled with a replacement of photoautotrophs by mixotrophic nanoflagellates (MNFs). The mechanism underlying these amplified phytoplanktonic responses was a dual control by MNFs on bacteria through the excretion of organic carbon and an increased top-down control by bacterivory. We also show across a 6-year whole-lake study that the changes from photoautotrophs to MNFs were related mainly to the frequency of pulsed nutrients (e.g. desert dust inputs). Our results underscore how an improved understanding of the interaction between chronic and stochastic environmental factors is critical for predicting ongoing changes in ecosystem functioning and its responses to climatically driven changes. PMID:28252666

  14. Broadband short pulse measurement by autocorrelation with a sum-frequency generation set-up

    SciTech Connect

    Glotin, F.; Jaroszynski, D.; Marcouille, O.

    1995-12-31

    Previous spectral and laser pulse length measurements carried out on the CLIO FEL at wavelength {lambda}=8.5 {mu}m suggested that very short light pulses could be generated, about 500 fs wide (FWHM). For these measurements a Michelson interferometer with a Te crystal, as a non-linear detector, was used as a second order autocorrelation device. More recent measurements in similar conditions have confirmed that the laser pulses observed are indeed single: they are not followed by other pulses distant by the slippage length N{lambda}. As the single micropulse length is likely to depend on the slippage, more measurements at different wavelengths would be useful. This is not directly possible with our actual interferometer set-up, based on a phase-matched non-linear crystal. However, we can use the broadband non-linear medium provided by one of our users` experiments: Sum-Frequency Generation over surfaces. With such autocorrelation set-up, interference fringes are no more visible, but this is largely compensated by the frequency range provided. First tests at 8 {mu}m have already been performed to validate the technic, leading to results similar to those obtained with our previous Michelson set-up.

  15. Rising nutrient-pulse frequency and high UVR strengthen microbial interactions

    NASA Astrophysics Data System (ADS)

    Cabrerizo, Marco J.; Medina-Sánchez, Juan Manuel; Dorado-García, Irene; Villar-Argaiz, Manuel; Carrillo, Presentación

    2017-03-01

    Solar radiation and nutrient pulses regulate the ecosystem’s functioning. However, little is known about how a greater frequency of pulsed nutrients under high ultraviolet radiation (UVR) levels, as expected in the near future, could alter the responses and interaction between primary producers and decomposers. In this report, we demonstrate through a mesocosm study in lake La Caldera (Spain) that a repeated (press) compared to a one-time (pulse) schedule under UVR prompted higher increases in primary (PP) than in bacterial production (BP) coupled with a replacement of photoautotrophs by mixotrophic nanoflagellates (MNFs). The mechanism underlying these amplified phytoplanktonic responses was a dual control by MNFs on bacteria through the excretion of organic carbon and an increased top-down control by bacterivory. We also show across a 6-year whole-lake study that the changes from photoautotrophs to MNFs were related mainly to the frequency of pulsed nutrients (e.g. desert dust inputs). Our results underscore how an improved understanding of the interaction between chronic and stochastic environmental factors is critical for predicting ongoing changes in ecosystem functioning and its responses to climatically driven changes.

  16. Pulse frequency and soil-litter mixing alter the control of cumulative precipitation over litter decomposition.

    PubMed

    Joly, François-Xavier; Kurupas, Kelsey L; Throop, Heather L

    2017-09-01

    Macroclimate has traditionally been considered the predominant driver of litter decomposition. However, in drylands, cumulative monthly or annual precipitation typically fails to predict decomposition. In these systems, the windows of opportunity for decomposer activity may rather depend on the precipitation frequency and local factors affecting litter desiccation, such as soil-litter mixing. We used a full-factorial microcosm experiment to disentangle the relative importance of cumulative precipitation, pulse frequency, and soil-litter mixing on litter decomposition. Decomposition, measured as litter carbon loss, saturated with increasing cumulative precipitation when pulses were large and infrequent, suggesting that litter moisture no longer increased and/or microbial activity was no longer limited by water availability above a certain pulse size. More frequent precipitation pulses led to increased decomposition at high levels of cumulative precipitation. Soil-litter mixing consistently increased decomposition, with greatest relative increase (+194%) under the driest conditions. Collectively, our results highlight the need to consider precipitation at finer temporal scale and incorporate soil-litter mixing as key driver of decomposition in drylands. © 2017 by the Ecological Society of America.

  17. Rising nutrient-pulse frequency and high UVR strengthen microbial interactions.

    PubMed

    Cabrerizo, Marco J; Medina-Sánchez, Juan Manuel; Dorado-García, Irene; Villar-Argaiz, Manuel; Carrillo, Presentación

    2017-03-02

    Solar radiation and nutrient pulses regulate the ecosystem's functioning. However, little is known about how a greater frequency of pulsed nutrients under high ultraviolet radiation (UVR) levels, as expected in the near future, could alter the responses and interaction between primary producers and decomposers. In this report, we demonstrate through a mesocosm study in lake La Caldera (Spain) that a repeated (press) compared to a one-time (pulse) schedule under UVR prompted higher increases in primary (PP) than in bacterial production (BP) coupled with a replacement of photoautotrophs by mixotrophic nanoflagellates (MNFs). The mechanism underlying these amplified phytoplanktonic responses was a dual control by MNFs on bacteria through the excretion of organic carbon and an increased top-down control by bacterivory. We also show across a 6-year whole-lake study that the changes from photoautotrophs to MNFs were related mainly to the frequency of pulsed nutrients (e.g. desert dust inputs). Our results underscore how an improved understanding of the interaction between chronic and stochastic environmental factors is critical for predicting ongoing changes in ecosystem functioning and its responses to climatically driven changes.

  18. Low frequency, ca. 40 Hz, pulse trains recorded in the humpback whale assembly in Hawaii.

    PubMed

    Darling, James D

    2015-11-01

    During studies of humpback whale song and social sounds in Hawaii, bouts of low frequency (ca. 40 Hz) pulses were periodically recorded. One example was made near an active group of eight adults (included 22 bouts, 2-13 s long, over 90 min); another close to an adult male-female pair (12 bouts, 9-93 s long, over 22 min). The mean peak and center frequencies (39 to 40 Hz) and bandwidth (13 Hz) were similar in both, but the organization of the pulses differed. Song components, social sounds, bubble trains, or other species do not provide a ready explanation for this sound.

  19. Neutron radiation effects on linear CCDs at different clock pulse frequency

    SciTech Connect

    Wang, Zujun Chen, Wei; Tang, Benqi; Xiao, Zhigang; Yao, Zhibin; He, Baoping; Liu, Minbo

    2015-06-15

    The experiments of reactor neutron radiation effects on linear CCDs are presented. The output voltage in dark field after neutron radiation are presented and compared at different clock pulse frequency. The degradation phenomena are analyzed in depth. The mean dark signal (K{sub D}) and dark signal non-uniformity (DSNU) versus neutron fluence is investigated at different clock pulse frequency. The degradation mechanisms of the dark signal and DSNU in linear CCDs are analyzed. The flux of the reactor neutron beams was about 1.33 × 10{sup 8} n/cm{sup 2}/s. The samples were exposed to 1MeV neutron-equivalent fluences of 1 × 10{sup 11}, 5 × 10{sup 11}, and 1 × 10{sup 12} n/cm{sup 2}, respectively.

  20. Properties of the welded joints of manganese steel made by low-frequency pulsed arc welding

    NASA Astrophysics Data System (ADS)

    Saraev, Yu. N.; Bezborodov, V. P.; Gladovskii, S. V.; Golikov, N. I.

    2017-04-01

    The structure, the mechanical properties, the impact toughness, and the fracture mechanisms of the welded joints made of steel 09G2S plates by direct current welding and pulsed arc welding with a modulated arc current in the frequency range 0.25-5.0 Hz are studied. The application of low-frequency pulsed arc welding allowed us to form welded joints with a fine-grained structure in the weld metal and the heat-affected zone and to achieve a higher impact toughness and a longer cyclic fatigue life as compared to the welded joints fabricated by direct current welding. The achieved effect manifests itself over the entire testing range from 20 to-60°C.

  1. Pulsed excitation system to measure the resonant frequency of magnetoelastic biosensors

    NASA Astrophysics Data System (ADS)

    Xie, Hong; Chai, Yating; Horikawa, Shin; Wikle, Howard C.; Chin, Bryan A.

    2014-05-01

    An electrical circuit was designed and tested to measure the resonant frequency of micron-scale magnetoelastic (ME) biosensors using a pulsed wave excitation technique. In this circuit, a square pulse current is applied to an excitation coil to excite the vibration of ME biosensors and a pick-up coil is used to sense the ME biosensor's mechanical vibration and convert it to an electrical output signal. The output signal is filtered and amplified by a custom designed circuit to allow the measurement of the resonant frequency of the ME biosensor from which the detection of specific pathogens can be made. As a proof-in-concept experiment, JRB7 phage-coated ME biosensors were used to detect different concentrations of Bacillus anthracis Sterne strain spores. A statistically significant difference was observed for concentrations of 5 × 102 spore/ml and above.

  2. Frequency-resolved optical-gating measurements of ultrashort pulses using surface third-harmonic generation

    SciTech Connect

    Tsang, T.; Krumbuegel, M.A.; DeLong, K.W.; Fittinghoff, D.N.; Trebino, R.

    1996-09-01

    We demonstrate what is to our knowledge the first frequency-resolved optical gating (FROG) technique to measure ultrashort pulses from an unamplified Ti:sapphire laser oscillator without direction-of-time ambiguity. This technique utilizes surface third-harmonic generation as the nonlinear-optical effect and, surprisingly, is the most sensitive third-order FROG geometry yet. {copyright} {ital 1996 Optical Society of America.}

  3. High efficiency, low frequency linear compressor proposed for Gifford-McMahon and pulse tube cryocoolers

    SciTech Connect

    Höhne, Jens

    2014-01-29

    In order to reduce the amount of greenhouse gas emissions, which are most likely the cause of substantial global warming, a reduction of overall energy consumption is crucial. Low frequency Gifford-McMahon and pulse tube cryocoolers are usually powered by a scroll compressor together with a rotary valve. It has been theoretically shown that the efficiency losses within the rotary valve can be close to 50%{sup 1}. In order to eliminate these losses we propose to use a low frequency linear compressor, which directly generates the pressure wave without using a rotary valve. First results of this development will be presented.

  4. Dual-comb coherent Raman spectroscopy with lasers of 1-GHz pulse repetition frequency.

    PubMed

    Mohler, Kathrin J; Bohn, Bernhard J; Yan, Ming; Mélen, Gwénaëlle; Hänsch, Theodor W; Picqué, Nathalie

    2017-01-15

    We extend the technique of multiplex coherent Raman spectroscopy with two femtosecond mode-locked lasers to oscillators of a pulse repetition frequency of 1 GHz. We demonstrate a spectra of liquids, which span 1100  cm-1 of Raman shifts. At a resolution of 6  cm-1, their measurement time may be as short as 5 μs for a refresh rate of 2 kHz. The waiting period between acquisitions is improved 10-fold compared to previous experiments with two lasers of 100-MHz repetition frequencies.

  5. High spatial frequency periodic structures induced on metal surface by femtosecond laser pulses.

    PubMed

    Yao, Jian-Wu; Zhang, Cheng-Yun; Liu, Hai-Ying; Dai, Qiao-Feng; Wu, Li-Jun; Lan, Sheng; Gopal, Achanta Venu; Trofimov, Vyacheslav A; Lysak, Tatiana M

    2012-01-16

    The high spatial frequency periodic structures induced on metal surface by femtosecond laser pulses was investigated experimentally and numerically. It is suggested that the redistribution of the electric field on metal surface caused by the initially formed low spatial frequency periodic structures plays a crucial role in the creation of high spatial frequency periodic structures. The field intensity which is initially localized in the grooves becomes concentrated on the ridges in between the grooves when the depth of the grooves exceeds a critical value, leading to the ablation of the ridges in between the grooves and the formation of high spatial frequency periodic structures. The proposed formation process is supported by both the numerical simulations based on the finite-difference time-domain technique and the experimental results obtained on some metals such as stainless steel and nickel.

  6. Quantification of cell membrane permeability induced by monopolar and high-frequency bipolar bursts of electrical pulses.

    PubMed

    Sweeney, Daniel C; Reberšek, Matej; Dermol, Janja; Rems, Lea; Miklavčič, Damijan; Davalos, Rafael V

    2016-11-01

    High-frequency bipolar electric pulses have been shown to mitigate undesirable muscle contraction during irreversible electroporation (IRE) therapy. Here, we evaluate the potential applicability of such pulses for introducing exogenous molecules into cells, such as in electrochemotherapy (ECT). For this purpose we develop a method for calculating the time course of the effective permeability of an electroporated cell membrane based on real-time imaging of propidium transport into single cells that allows a quantitative comparison between different pulsing schemes. We calculate the effective permeability for several pulsed electric field treatments including trains of 100μs monopolar pulses, conventionally used in IRE and ECT, and pulse trains containing bursts or evenly-spaced 1μs bipolar pulses. We show that shorter bipolar pulses induce lower effective membrane permeability than longer monopolar pulses with equivalent treatment times. This lower efficiency can be attributed to incomplete membrane charging. Nevertheless, bipolar pulses could be used for increasing the uptake of small molecules into cells more symmetrically, but at the expense of higher applied voltages. These data indicate that high-frequency bipolar bursts of electrical pulses may be designed to electroporate cells as effectively as and more homogeneously than conventional monopolar pulses. Copyright © 2016 Elsevier B.V. All rights reserved.

  7. Human exposure to pulsed fields in the frequency range from 6 to 100 GHz

    NASA Astrophysics Data System (ADS)

    Laakso, Ilkka; Morimoto, Ryota; Heinonen, Juhani; Jokela, Kari; Hirata, Akimasa

    2017-09-01

    Restrictions on human exposure to electromagnetic waves at frequencies higher than 3-10 GHz are defined in terms of the incident power density to prevent excessive temperature rise in superficial tissue. However, international standards and guidelines differ in their definitions of how the power density is interpreted for brief exposures. This study investigated how the temperature rise was affected by exposure duration at frequencies higher than 6 GHz. Far-field exposure of the human face to pulses shorter than 10 s at frequencies from 6 to 100 GHz was modelled using the finite-difference time-domain method. The bioheat transfer equation was used for thermal modelling. We investigated the effects of frequency, polarization, exposure duration, and depth below the skin surface on the temperature rise. The results indicated limitations in the current human exposure guidelines and showed that radiant exposure, i.e. energy absorption per unit area, can be used to limit temperature rise for pulsed exposure. The data are useful for the development of human exposure guidelines at frequencies higher than 6 GHz.

  8. COMPARISON OF RADIO-FREQUENCY INTERFERENCE MITIGATION STRATEGIES FOR DISPERSED PULSE DETECTION

    SciTech Connect

    Hogden, John; Vander Wiel, Scott; Michalak, Sarah; Bower, Geoffrey C.; Siemion, Andrew; Werthimer, Daniel

    2012-03-10

    Impulsive radio-frequency signals from astronomical sources are dispersed by the frequency-dependent index of refraction of the interstellar media and so appear as chirped signals when they reach Earth. Searches for dispersed impulses have been limited by false detections due to radio-frequency interference (RFI) and, in some cases, artifacts of the instrumentation. Many authors have discussed techniques to excise or mitigate RFI in searches for fast transients, but comparisons between different approaches are lacking. This work develops RFI mitigation techniques for use in searches for dispersed pulses, employing data recorded in a 'Fly's Eye' mode of the Allen Telescope Array as a test case. We gauge the performance of several RFI mitigation techniques by adding dispersed signals to data containing RFI and comparing false alarm rates at the observed signal-to-noise ratios of the added signals. We find that Huber filtering is most effective at removing broadband interferers, while frequency centering is most effective at removing narrow frequency interferers. Neither of these methods is effective over a broad range of interferers. A method that combines Huber filtering and adaptive interference cancelation provides the lowest number of false positives over the interferers considered here. The methods developed here have application to other searches for dispersed pulses in incoherent spectra, especially those involving multiple beam systems.

  9. Effect of master oscillator stability over pulse repetition frequency on hybrid semiconductor mode-locked laser

    NASA Astrophysics Data System (ADS)

    Castro Alves, D.; Abreu, Manuel; Cabral, Alexandre; Rebordão, J. M.

    2015-04-01

    Semiconductor mode-locked lasers are a very attractive laser pulse source for high accuracy length metrology. However, for some applications, this kind of device does not have the required frequency stability. Operating the laser in hybrid mode will increase the laser pulse repetition frequency (PRF) stability. In this study it is showed that the laser PRF is not only locked to the master oscillator but also maintains the same level of stability of the master oscillator. The device used in this work is a 10 mm long mode-locked asymmetrical cladding single section InAs/InP quantum dash diode laser emitting at 1580 nm with a pulse repetition frequency of ≈4.37 GHz. The laser nominal stability in passive mode (no external oscillator) shows direct dependence with the gain current and the stability range goes from 10-4 to 10-7. Several oscillators with different stabilities were used for the hybrid-mode operation (with external oscillator) and the resulting mode-locked laser stability compared. For low cost oscillators with low stability, the laser PRF stability achieves a value of 10-7 and for higher stable oscillation source (such as oven controlled quartz oscillators (OXCO)) the stability can reach values up to 10-12 (τ =1 s).

  10. Pulsed single-photon spectrometer by frequency-to-time mapping using chirped fiber Bragg gratings

    NASA Astrophysics Data System (ADS)

    Davis, Alex O. C.; Saulnier, Paul M.; Karpiński, Michał; Smith, Brian J.

    2017-05-01

    A fiber-integrated spectrometer for single-photon pulses outside the telecommunications wavelength range based upon frequency-to-time mapping, implemented by chromatic group delay dispersion (GDD), and precise temporally-resolved single-photon counting, is presented. A chirped fiber Bragg grating provides low-loss GDD, mapping the frequency distribution of an input pulse onto the temporal envelope of the output pulse. Time-resolved detection with fast single-photon-counting modules enables monitoring of a wavelength range from 825 nm to 835 nm with nearly uniform efficiency at 55 pm resolution (24 GHz at 830 nm). To demonstrate the versatility of this technique, spectral interference of heralded single photons and the joint spectral intensity distribution of a photon-pair source are measured. This approach to single-photon-level spectral measurements provides a route to realize applications of time-frequency quantum optics at visible and near-infrared wavelengths, where multiple spectral channels must be simultaneously monitored.

  11. Compression of pulses during their amplification in the field of a focused counterpropagating pump pulse of the same frequency and width in media with electrostriction nonlinearity

    SciTech Connect

    Dement'ev, Aleksandr S; Demin, I; Murauskas, E; Slavinskis, S

    2011-02-28

    Efficient compression of focused {approx}0.9-ns pulses of a miniature Nd:YAG laser to less than 60 ps is experimentally obtained at their interaction with counterpropagating pulses of the same carrier frequency and width in CCl{sub 4}. In this case, electrostriction interaction (amplification) begins not from the level of spontaneous-scattering noise; therefore, the counterpropagating pulses can be compressed at pump pulse energies below the stimulated Brillouin scattering (SBS) threshold energies. When counterpropagating seed pulses are used, the energy and temporal stability of compressed pulses are several times higher, and their time jitter is smaller than that for SBS compression from the level of spontaneous-scattering noise. (nonlinear optical phenomena)

  12. Differentiation of osteoprogenitor cells is induced by high-frequency pulsed electromagnetic fields.

    PubMed

    Teven, Chad M; Greives, Matthew; Natale, Ryan B; Su, Yuxi; Luo, Qing; He, Bai-Cheng; Shenaq, Deana; He, Tong-Chuan; Reid, Russell R

    2012-03-01

    Craniofacial defect repair is often limited by a finite supply of available autologous tissue (ie, bone) and less than ideal alternatives. Therefore, other methods to produce bony healing must be explored. Several studies have demonstrated that low-frequency pulsed electromagnetic field (PEMF) stimulation (ie, 5-30 Hz) of osteoblasts enhances bone formation. The current study was designed to investigate whether a Food and Drug Administration-approved, high-frequency PEMF-emitting device is capable of inducing osteogenic differentiation of osteoprogenitor cells. Osteoprogenitor cells (commercially available C3H10T1/2 and mouse calvarial) in complete Dulbecco modified Eagle medium were continuously exposed to PEMF stimulation delivered by the ActiPatch at a frequency of 27.1 MHz. Markers of cellular proliferation and early, intermediate, and terminal osteogenic differentiation were measured and compared with unstimulated controls. All experiments were performed in triplicate. High-frequency PEMF stimulation increases alkaline phosphatase activity in both cell lines. In addition, high-frequency PEMF stimulation augments osteopontin and osteocalcin expression as well as mineral nodule formation in C3H10T1/2 cells, indicating late and terminal osteogenic differentiation, respectively. Cellular proliferation, however, was unaffected by high-frequency PEMF stimulation. Mechanistically, high-frequency PEMF-stimulated osteogenic differentiation is associated with elevated mRNA expression levels of osteogenic bone morphogenetic proteins in C3H10T1/2 cells. Our findings suggest that high-frequency PEMF stimulation of osteoprogenitor cells may be explored as an effective tissue engineering strategy to treat critical-size osseous defects of the craniofacial and axial skeleton. ALP, alkaline phosphatase; BMP, bone morphogenetic protein; ERK-1, extracellular signal-regulated kinase 1; iCALs, immortalized calvarial cells; IHC, immunohistochemical; MAP, mitogen-activated protein

  13. Frequency Domain Analysis of a Gas Fired Mechanically Valved Pulse Combustor

    NASA Astrophysics Data System (ADS)

    Neumeier, Yedidia

    1993-01-01

    This study presents an analysis of a mechanically valved pulse combustor in the frequency domain. The pulse combustor is treated as a feedback system. The forward branch of the system consists of the acoustic resonator, while the feedback loop consists of the combustion heat release process and the heat loss through the pulse combustor walls. The model of the acoustic resonator is based upon an analysis of the conservation equation for the combustion chamber energy oscillations and the tail pipe acoustics. The present study utilizes a phenomenological approach to model the periodic heat release process in the combustor. The model accounts for the mixing of cold reactants with hot products, flame extinction due to high velocities during the injection time, and the kinetics of the chemical reaction. The results of this study indicate that a high periodic heat transfer must take place in the combustion zone of mechanically valved pulse combustors. The intensity of this oscillating heat transfer is an order of magnitude larger than has been observed until the present study. The results imply that the unsteady heat transfer contributes vital feedback that stabilizes the limit cycle of the pulse combustor. The study was extended to include preliminary experimental evidence for the existence of a very high wall heat losses in the combustion zone, as predicted by the model. No model of pulse combustor that fails to account for unsteady heat transfer in the combustion zone can be considered fully accurate. A calibration procedure is developed to optimize the model prediction. This calibration process is oriented to provide an accurate prediction of the important parameters; namely, the pressure level and the operating frequency, at the cost of less accuracy in predicting relatively less important parameters. The model developed in the study has been used to develop a software package application for design and analysis of pulse combustors. The use of the software for pulse

  14. Compact field programmable gate array-based pulse-sequencer and radio-frequency generator for experiments with trapped atoms

    SciTech Connect

    Pruttivarasin, Thaned; Katori, Hidetoshi

    2015-11-15

    We present a compact field-programmable gate array (FPGA) based pulse sequencer and radio-frequency (RF) generator suitable for experiments with cold trapped ions and atoms. The unit is capable of outputting a pulse sequence with at least 32 transistor-transistor logic (TTL) channels with a timing resolution of 40 ns and contains a built-in 100 MHz frequency counter for counting electrical pulses from a photo-multiplier tube. There are 16 independent direct-digital-synthesizers RF sources with fast (rise-time of ∼60 ns) amplitude switching and sub-mHz frequency tuning from 0 to 800 MHz.

  15. Synthesis of Optical Frequencies and Ultrastable Femtosecond Pulse Trains from an Optical Reference Oscillator

    NASA Astrophysics Data System (ADS)

    Bartels, A.; Ramond, T. M.; Diddams, S. A.; Hollberg, L.

    Recently, atomic clocks based on optical frequency standards have been demonstrated [1,2]. A key element in these clocks is a femtosecond laser that downconverts the petahertz oscillation rate into countable ticks at 1 GHz. When compared to current microwave standards, these new optical clocks are expected to yield an improvement in stability and accuracy by roughly a factor of 1000. Furthermore, it is possible that the lowest noise microwave sources will soon be based on atomically-stabilized optical oscillators that have their frequency converted to the microwave domain via a femtosecond laser. Here, we present tests of the ability of femtosecond lasers to transfer stability from an optical oscillator to their repetition rates as well as to the associated broadband frequency comb. In a first experiment, we phase-lock two lasers to a stabilized laser diode and find that the relative timing jitter in their pulse trains can be on the order of 1 femtosecond in a 100 kHz bandwidth. It is important to distinguish this technique from previous work where a femtosecond laser has been stabilized to a microwave standard [3,4] or another femtosecond laser [5]. Furthermore, we extract highly stable microwave signals with a fractional frequency instability of 2×10-14 in 1 s by photodetection of the laser pulse trains. In a second experiment, we similarly phase-lock the femtosecond laser to an optical oscillator with linewidth less than 1 Hz [6]. The precision with which we can make the femtosecond frequency comb track this reference oscillator is then tested by a heterodyne measurement between a second stable optical oscillator and a mode of the frequency comb that is displaced 76 THz from the 1 Hz-wide reference. From this heterodyne signal we place an upper limit of 150 Hz on the linewidth of the elements of the frequency comb, limited by the noise in the measurement itself.

  16. Pulsed arrays: A new method of flaw detection by generating a frequency dependent angle of propagation

    NASA Astrophysics Data System (ADS)

    Hill, S. J.; Dixon, S. M.

    2012-05-01

    A new method of using an array of generation sources, pulsed simultaneously to generate a wavefront with a frequency dependant angle of propagation, has been developed. If pulsed arrays are used to generate a wave with a frequency dependent angle of propagation, the angle at which the wave was launched can be identified by measuring the frequency of the detected wave. In an isotropic material this means that it is possible use a second transducer to locate the position of the scatterer, whereas with a conventional single element generator method, it can only be located onto an ellipse. In addition to an increased scan speed, the resolution of detection should also be improved. A theoretical framework is put forward to explain how the wavefront is created from the superposition of the waves from the individual elements, and how the frequency varies along the wavefront. Finite element models and experimental measurements were also carried out, and both agreed with the analytic model. This method will have applications within NDE, but could also extend to sonar and radar techniques.

  17. Distribution of Argon Arc Contaminated with Nitrogen as Function of Frequency in Pulsed TIG Welding

    NASA Astrophysics Data System (ADS)

    Takahashi, Hiroki; Tanaka, Tatsuro; Yamamoto, Shinji; Iwao, Toru

    2016-09-01

    TIG arc welding is the high-quality and much applicable material joining technology. However, the current has to be small because the cathode melting should be prevented. In this case, the heat input to the welding pool becomes low, then, the welding defect sometimes occurs. The pulsed TIG arc welding is used to improve this disadvantage This welding can be controlled by some current parameters such as frequency However, few report has reported the distribution of argon arc contaminated with nitrogen It is important to prevent the contamination of nitrogen because the melting depth increases in order to prevent the welding defects. In this paper, the distribution of argon arc contaminated as function of frequency with nitrogen in pulsed TIG welding is elucidated. The nitrogen concentration, the radial flow velocity, the arc temperature were calculated using the EMTF simulation when the time reached at the base current. As a result, the nitrogen concentration into the arc became low with increasing the frequency The diffusion coefficient decreased because of the decrement of temperature over 4000 K. In this case, the nitrogen concentration became low near the anode. Therefore, the nitrogen concentration became low because the frequency is high.

  18. Loss of echogenicity and onset of cavitation from echogenic liposomes: pulse repetition frequency independence.

    PubMed

    Radhakrishnan, Kirthi; Haworth, Kevin J; Peng, Tao; McPherson, David D; Holland, Christy K

    2015-01-01

    Echogenic liposomes (ELIP) are being developed for the early detection and treatment of atherosclerotic lesions. An 80% loss of echogenicity of ELIP has been found to be concomitant with the onset of stable and inertial cavitation. The ultrasound pressure amplitude at which this occurs is weakly dependent on pulse duration. It has been reported that the rapid fragmentation threshold of ELIP (based on changes in echogenicity) is dependent on the insonation pulse repetition frequency (PRF). The study described here evaluates the relationship between loss of echogenicity and cavitation emissions from ELIP insonified by duplex Doppler pulses at four PRFs (1.25, 2.5, 5 and 8.33 kHz). Loss of echogenicity was evaluated on B-mode images of ELIP. Cavitation emissions from ELIP were recorded passively on a focused single-element transducer and a linear array. Emissions recorded by the linear array were beamformed, and the spatial widths of stable and inertial cavitation emissions were compared with the calibrated azimuthal beamwidth of the Doppler pulse exceeding the stable and inertial cavitation thresholds. The inertial cavitation thresholds had a very weak dependence on PRF, and stable cavitation thresholds were independent of PRF. The spatial widths of the cavitation emissions recorded by the passive cavitation imaging system agreed with the calibrated Doppler beamwidths. The results also indicate that 64%-79% loss of echogenicity can be used to classify the presence or absence of cavitation emissions with greater than 80% accuracy.

  19. Design and prototyping of a large capacity high frequency pulse tube

    NASA Astrophysics Data System (ADS)

    Ercolani, E.; Poncet, J. M.; Charles, I.; Duband, L.; Tanchon, J.; Trollier, T.; Ravex, A.

    2008-09-01

    This document describes the design and the prototyping performed at CEA/SBT in partnership with AIR LIQUIDE of a high frequency large cooling power pulse tube. Driven at 58 Hz by a 7.5 kW flexure bearing pressure wave generator, this system provides a net heat lift of 210 W at 65 K. The phase shift is obtained by an inertance and a buffer volume. This type of cryogenic cooler can be used for on site gas liquefaction or drilling site and for high temperature superconductivity power device cooling (transmission lines, large generators, fault current limiters). In this paper, we focus on two essential points, the regenerator and the flow straightener. The regenerator is a key component for good performance of the pulse tube cooler. It must have a large thermal inertia, a low dead volume, a good heat transfer gas/matrix and at the same time, small pressure drop. In the present case and unlike typical moderate cooling power pulse tubes, the regenerator is very compact. However, the resulting conductive losses remain negligible compared to the cooling power targeted. The goal of the flow straightener is to avoid as much as possible any jet stream effect and to guarantee the uniformity of the velocity field at both ends of the pulse tube. Indeed multi-dimensional flow effects can significantly impact the performances of the machine.

  20. Radio frequency pulse compression experiments at SLAC (Stanford Linear Accelerator Center)

    SciTech Connect

    Farkas, Z.D.; Lavine, T.L.; Menegat, A.; Miller, R.H.; Nantista, C.; Spalek, G.; Wilson, P.B.

    1991-01-01

    Proposed future positron-electron linear colliders would be capable of investigating fundamental processes of interest in the 0.5--5 TeV beam-energy range. At the SLAC Linear Collider (SLC) gradient of about 20 MV/m this would imply prohibitive lengths of about 50--250 kilometers per linac. We can reduce the length by increasing the gradient but this implies high peak power, on the order of 400-- to 1000-MW at X-Band. One possible way to generate high peak power is to generate a relatively long pulse at a relatively low power and compress it into a short pulse with higher peak power. It is possible to compress before DC to RF conversion, as is done using magnetic switching for induction linacs, or after DC to RF conversion, as is done for the SLC. Using RF pulse compression it is possible to boost the 50-- to 100-MW output that has already been obtained from high-power X-Band klystrons the levels required by the linear colliders. In this note only radio frequency pulse compression (RFPC) is considered.

  1. Detection and Characterization of Flaws in Sprayed on Foam Insulation with Pulsed Terahertz Frequency Electromagnetic Waves

    NASA Technical Reports Server (NTRS)

    Winfree, William P.; Madaras, Eric I.

    2005-01-01

    The detection and repair of flaws such as voids and delaminations in the sprayed on foam insulation of the external tank reduces the probability of foam debris during shuttle ascent. The low density of sprayed on foam insulation along with it other physical properties makes detection of flaws difficult with conventional techniques. An emerging technology that has application for quantitative evaluation of flaws in the foam is pulsed electromagnetic waves at terahertz frequencies. The short wavelengths of these terahertz pulses make them ideal for imaging flaws in the foam. This paper examines the application of terahertz pulses for flaw detection in foam characteristic of the foam insulation of the external tank. Of particular interest is the detection of voids and delaminations, encapsulated in the foam or at the interface between the foam and a metal backing. The technique is shown to be capable of imaging small voids and delaminations through as much as 20 cm of foam. Methods for reducing the temporal responses of the terahertz pulses to improve flaw detection and yield quantitative characterizations of the size and location of the flaws are discussed.

  2. Time resolved dosimetry of human brain exposed to low frequency pulsed magnetic fields

    NASA Astrophysics Data System (ADS)

    Paffi, Alessandra; Camera, Francesca; Lucano, Elena; Apollonio, Francesca; Liberti, Micaela

    2016-06-01

    An accurate dosimetry is a key issue to understanding brain stimulation and related interaction mechanisms with neuronal tissues at the basis of the increasing amount of literature revealing the effects on human brain induced by low-level, low frequency pulsed magnetic fields (PMFs). Most literature on brain dosimetry estimates the maximum E field value reached inside the tissue without considering its time pattern or tissue dispersivity. Nevertheless a time-resolved dosimetry, accounting for dispersive tissues behavior, becomes necessary considering that the threshold for an effect onset may vary depending on the pulse waveform and that tissues may filter the applied stimulatory fields altering the predicted stimulatory waveform’s size and shape. In this paper a time-resolved dosimetry has been applied on a realistic brain model exposed to the signal presented in Capone et al (2009 J. Neural Transm. 116 257-65), accounting for the broadband dispersivity of brain tissues up to several kHz, to accurately reconstruct electric field and current density waveforms inside different brain tissues. The results obtained by exposing the Duke’s brain model to this PMF signal show that the E peak in the brain is considerably underestimated if a simple monochromatic dosimetry is carried out at the pulse repetition frequency of 75 Hz.

  3. A new minimum fluorescence parameter, as generated using pulse frequency modulation, compared with pulse amplitude modulation: Falpha versus Fo.

    PubMed

    Wright, A Harrison; DeLong, John M; Franklin, Jeffrey L; Lada, Rajasekaran R; Prange, Robert K

    2008-09-01

    The minimum fluorescence parameter (Falpha), generated using the new pulse frequency modulation (PFM) technology, was compared with the minimum fluorescence parameter (Fo), generated by pulse amplitude modulation (PAM), in response to a reversible low-oxygen stress in 'Honeycrisp'trade mark (HC) apples (Malus domestica) and an irreversible osmotic stress induced by water loss in two grape (Vitis spp.) cultivars ('L'Acadie' (LAc) and 'Thompson Seedless' (TS)). The minimum fluorescence values produced by both fluorometer types in response to a reversible low-oxygen stress in apples were indistinguishable: both Fo and Falpha increased when O2 levels were lowered below the anaerobic compensation point (ACP); when gas levels returned to normoxia both parameters dipped below, then returned to, the original fluorescence baseline. The two parameters also responded similarly to the irreversible osmotic stress in grapes: in both cultivars, Falpha and Fo first decreased before reaching an inflection point at approximately 20% mass loss and then increased towards a second inflection point. However, the two parameters were not analogous under the irreversible osmotic stress; most notably, the relative Falpha values appeared to be lower than Fo during the later stages of dehydration. This was likely due to the influence of the Fm parameter and an overestimation of Falpha when measuring the fluorescence from healthy and responsive chloroplasts as found in grapes experiencing minimal water loss, but not in grapes undergoing moderate to severe dehydration. An examination of the data during a typical PFM scan reveals this fluorometer system may yield new fluorescence information with interesting biological applications.

  4. Constant frequency pulsed phase-locked-loop instrument for measurement of ultrasonic velocity

    NASA Astrophysics Data System (ADS)

    Yost, William T.; Cantrell, John H.; Kushnick, Peter W.

    1991-10-01

    A new instrument based on a constant-frequency pulsed phase-locked-loop (CFPPLL) concept has been developed to accurately measure the ultrasonic wave velocity in liquids and changes in ultrasonic wave velocity in solids and liquids. An analysis of the system shows that it is immune to many of the frequency-dependent effects that plague other techniques. Measurements of the sound velocity in ultrapure water are used to confirm the analysis. The results are in excellent agreement with values from the literature, and establish that the CFPPLL provides a reliable, accurate way to measure velocities, as well as for monitoring small changes in velocity without the sensitivity to frequency-dependent phase shifts common to other measurement systems. The estimated sensitivity to phase changes is better than a few parts in 10 to the 7th.

  5. Constant frequency pulsed phase-locked-loop instrument for measurement of ultrasonic velocity

    SciTech Connect

    Yost, William T; Cantrell, John H; Kushnick, Peter W

    1991-10-01

    A new instrument based on a constant frequency pulsed phase-locked-loop (CFPPLL) concept has been developed to accurately measure the ultrasonicwavevelocity in liquids and changes in ultrasonicwavevelocity in solids and liquids. An analysis of the system shows that it is immune to many of the frequency-dependent effects that plague other techniques including the constant phase shifts of reflectors placed in the path of the ultrasonicwave.Measurements of the sound velocity in ultrapure water are used to confirm the analysis. The results are in excellent agreement with values from the literature, and establish that the CFPPLL provides a reliable, accurate way to measurevelocities, as well as for monitoring small changes in velocity without the sensitivity to frequency-dependent phase shifts common to other measurement systems. The estimated sensitivity to phase changes is better than a few parts in 10{sup 7}.

  6. Constant frequency pulsed phase-locked-loop instrument for measurement of ultrasonic velocity

    NASA Technical Reports Server (NTRS)

    Yost, William T.; Cantrell, John H.; Kushnick, Peter W.

    1991-01-01

    A new instrument based on a constant-frequency pulsed phase-locked-loop (CFPPLL) concept has been developed to accurately measure the ultrasonic wave velocity in liquids and changes in ultrasonic wave velocity in solids and liquids. An analysis of the system shows that it is immune to many of the frequency-dependent effects that plague other techniques. Measurements of the sound velocity in ultrapure water are used to confirm the analysis. The results are in excellent agreement with values from the literature, and establish that the CFPPLL provides a reliable, accurate way to measure velocities, as well as for monitoring small changes in velocity without the sensitivity to frequency-dependent phase shifts common to other measurement systems. The estimated sensitivity to phase changes is better than a few parts in 10 to the 7th.

  7. Constant frequency pulsed phase-locked-loop instrument for measurement of ultrasonic velocity

    NASA Technical Reports Server (NTRS)

    Yost, William T.; Cantrell, John H.; Kushnick, Peter W.

    1991-01-01

    A new instrument based on a constant-frequency pulsed phase-locked-loop (CFPPLL) concept has been developed to accurately measure the ultrasonic wave velocity in liquids and changes in ultrasonic wave velocity in solids and liquids. An analysis of the system shows that it is immune to many of the frequency-dependent effects that plague other techniques. Measurements of the sound velocity in ultrapure water are used to confirm the analysis. The results are in excellent agreement with values from the literature, and establish that the CFPPLL provides a reliable, accurate way to measure velocities, as well as for monitoring small changes in velocity without the sensitivity to frequency-dependent phase shifts common to other measurement systems. The estimated sensitivity to phase changes is better than a few parts in 10 to the 7th.

  8. Ultrashort-pulse Ti:sapphire laser system pumped by frequency-doubled Nd:glass lasers

    NASA Astrophysics Data System (ADS)

    Bonlie, James D.; Price, Dwight F.; Sullivan, Alan; White, William E.

    1996-05-01

    We report on the development of a Chirped Pulse Amplification system in which the final amplifier is a large Ti:Sapphire disk pumped by a frequency doubled Nd:Glass laser. Using this amplifier we have produced near diffraction limited 120 fs pulses with energies in excess of 1 J. Focusing of these pulses results in peak irradiances exceeding 5 X 1019 W/cm2. The scalability of this amplifier to the 10 - 20 J level is also discussed.

  9. Generation of high-energy self-phase-stabilized pulses by difference-frequency generation followed by optical parametric amplification.

    PubMed

    Manzoni, C; Vozzi, C; Benedetti, E; Sansone, G; Stagira, S; Svelto, O; De Silvestri, S; Nisoli, M; Cerullo, G

    2006-04-01

    We produce ultrabroadband self-phase-stabilized near-IR pulses by a novel approach where a seed pulse, obtained by difference-frequency generation of a hollow-fiber broadened supercontinuum, is amplified by a two-stage optical parametric amplifier. Energies up to 20 microJ with a pulse spectrum extending from 1.2 to 1.6 microm are demonstrated, and a route for substantial energy scaling is indicated.

  10. Stabilization and time resolved measurement of the frequency evolution of a modulated diode laser for chirped pulse generation

    NASA Astrophysics Data System (ADS)

    Varga-Umbrich, K.; Bakos, J. S.; Djotyan, G. P.; Ignácz, P. N.; Ráczkevi, B.; Sörlei, Zs; Szigeti, J.; Kedves, M. Á.

    2016-05-01

    We have developed experimental methods for the generation of chirped laser pulses of controlled frequency evolution in the nanosecond pulse length range for coherent atomic interaction studies. The pulses are sliced from the radiation of a cw external cavity diode laser while its drive current, and consequently its frequency, are sinusoidally modulated. By the proper choice of the modulation parameters, as well as of the timing of pulse slicing, we can produce a wide variety of frequency sweep ranges during the pulse. In order to obtain the required frequency chirp, we need to stabilize the center frequency of the modulated laser and to measure the resulting frequency evolution with appropriate temporal resolution. These tasks have been solved by creating a beat signal with a reference laser locked to an atomic transition frequency. The beat signal is then analyzed, as well as its spectral sideband peaks are fed back to the electronics of the frequency stabilization of the modulated laser. This method is simple and it has the possibility for high speed frequency sweep with narrow linewidth that is appropriate, for example, for selective manipulation of atomic states in a magneto-optical trap.

  11. Decrease of pulse-contrast in nonlinear chirped-pulse amplification systems due to high-frequency spectral phase ripples.

    PubMed

    Schimpf, Damian; Seise, Enrico; Limpert, Jens; Tünnermann, Andreas

    2008-06-09

    It is analytically shown that weak initial spectral phase modulations cause a pulse-contrast degradation at the output of nonlinear chirped-pulse amplification systems. The Kerr-nonlinearity causes an energy-transfer from the main pulse to side-pulses during nonlinear amplification. The relative intensities of these side-pulses can be described in terms of Bessel-functions. It is shown that the intensities of the pulses are dependent on the magnitude of the accumulated nonlinear phase-shift (i.e., the B-integral), the depth and period of the initial spectral phase-modulation and the slope of the linear stretching chirp. The results are applicable to any type of laser amplifier that is based on the technique of chirped-pulse amplification. The analytical results presented in this paper are of particular importance for high peak-power laser applications requiring high pulse-contrasts, e.g. high field physics.

  12. Precipitation pulse size and frequency controls on dryland litter decomposition rates

    NASA Astrophysics Data System (ADS)

    Kurupas, K. L.; Throop, H.

    2014-12-01

    Drylands are an important component of the global carbon (C) cycle, accounting for 40% of the land area and 20% of the soil organic C globally. Litter decomposition is a key biogeochemical process, controlling C and nutrient cycling. While simple decomposition models successfully predict decomposition rates in many systems based on climate variables, there is a disconnect between the modeled and measured rates decomposition in drylands. This disconnect may stem from abiotic factors of importance in drylands, such as photodegradation and soil-litter mixing, not being taken into account. Soil-litter mixing can accelerate decomposition, but the underlying mechanisms are poorly understood. Potential mechanisms include microclimate buffering, physical abrasion, and enhanced microbial colonization. Recent work suggests that litter decomposition is remarkably insensitive to climate variables, at least when variables are presented as long temporal-scale values (e.g., annual precipitation). We hypothesized that decomposition would be more strongly affected by litter moisture content than total precipitation (PPT) alone. Thus, frequent, small PPT pulses would accelerate decomposition more than larger, but infrequent pulses. Furthermore, soil-litter mixing would enhance decomposition by buffering litter moisture content. To test the combined influence of soil-litter mixing and PPT pulses on decomposition, we incubated litter and soil in a semi-controlled greenhouse which simulated dryland summer temperatures. Two litter types (grass and shrub) were incubated under two levels of soil-litter mixing (no mixing and complete soil-litter mixing) and with 16 different PPT treatments (a factorial combination of four PPT pulses sizes and four PPT frequencies). We measured instantaneous CO2 flux throughout the 30 day incubation and mass loss at the end of the incubation. Shrub litter decomposed faster than grass litter. Flux rates generally peaked at day 8 and declined thereafter. CO2

  13. 100μJ-level single frequency linearly-polarized nanosecond pulsed laser at 775 nm (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Shi, Wei; Fang, Qiang; Fan, Jingli; Cui, Xuelong; Zhang, Zhuo; Li, Jinhui; Zhou, Guoqing

    2017-02-01

    We report a single frequency, linearly polarized, near diffraction-limited, pulsed laser source at 775 nm by frequency doubling a single frequency nanosecond pulsed all fiber based master oscillator-power amplifier, seeded by a fiber coupled semiconductor DFB laser diode at 1550 nm. The laser diode was driven by a pulsed laser driver to generate 5 ns laser pulses at 260 Hz repetition rate with 50 pJ pulse energy. The pulse energy was boosted to 200 μJ using two stages of core-pumped fiber amplifiers and two stages of cladding-pumped fiber amplifiers. The multi-stage synchronous pulse pumping technique was adopted in the four stages of fiber amplifiers to mitigate the ASE. The frequency doubling is implemented in a single pass configuration using a periodically poled lithium niobate (PPLN) crystal. The crystal is 3 mm long, 1.4 mm wide, 1 mm thick, with a 19.36 μm domain period chosen for quasi-phase matching at 33°C. It was AR coated at both 1550 nm and 775 nm. The maximum pulse energy of 97 μJ was achieved when 189 μJ fundamental laser was launched. The corresponding conversion efficiency is about 51.3%. The pulse duration was measured to be 4.8 ns. So the peak power of the generated 775 nm laser pulses reached 20 kW. To the best of our knowledge, this is the first demonstration of a 100 μJ-level, tens of kilowatts-peak-power-level single frequency linearly polarized 775 nm laser based on the frequency doubling of the fiber lasers.

  14. Effect of photoperiod on LH, FSH, prolactin and melatonin patterns in ovariectomized prepubertal heifers.

    PubMed

    Critser, J K; Block, T M; Folkman, S; Hauser, E R

    1987-09-01

    Angus and Angus crossbred prepubertal heifers were ovariectomized and randomly assigned to either increasing light simulating the photoperiod of the vernal equinox to the summer solstice (I) or decreasing light simulating the photoperiod of the autumnal equinox to the winter solstice (D) for 43 degrees N latitude. Three blood samples were taken each week for 14 weeks, the first at 11:00 h and two others 2 days later, 1 h before lights on (dark), 1 h before lights off (light). At the end of 14 weeks 4 heifers from each treatment group were cannulated and samples were taken for 12 h at 15-min intervals, 6 h in the light and 6 h in the dark. All sera were assayed for LH, FSH and prolactin. In addition, the samples taken at 15-min intervals were assayed for melatonin. In samples taken weekly at 11:00 h circulating concentrations of LH and prolactin were higher among animals in Group I, while FSH concentrations were not different between Groups D and I. In samples collected weekly in the light or the dark, LH and prolactin concentrations were higher in Group I animals. However, prolactin concentrations were higher and LH concentrations tended to be higher in samples taken in the dark. FSH concentrations were not different between either D or I or dark and light. In samples taken at 15-min intervals the prolactin baseline was higher and pulse amplitude tended to be higher for Group I animals. Neither LH nor FSH pulse characteristics differed between I and D; however, LH baseline and LH pulse amplitude were higher in the dark. Melatonin pulse amplitude was higher among animals in Group D and higher in serum collected in the dark. These results suggest that photoperiod alters circulating concentrations of LH and prolactin and alters pulsatile release of LH, prolactin and melatonin in the prepubertal heifer.

  15. Radio-frequency oxygen-plasma-enhanced pulsed laser deposition of IGZO films

    NASA Astrophysics Data System (ADS)

    Chou, Chia-Man; Lai, Chih-Chang; Chang, Chih-Wei; Wen, Kai-Shin; Hsiao, Vincent K. S.

    2017-07-01

    We demonstrate the crystalline structures, optical transmittance, surface and cross-sectional morphologies, chemical compositions, and electrical properties of indium gallium zinc oxide (IGZO)-based thin films deposited on glass and silicon substrates through pulsed laser deposition (PLD) incorporated with radio-frequency (r.f.)-generated oxygen plasma. The plasma-enhanced pulsed laser deposition (PEPLD)-based IGZO thin films exhibited a c-axis-aligned crystalline (CAAC) structure, which was attributed to the increase in Zn-O under high oxygen vapor pressure (150 mTorr). High oxygen vapor pressure (150 mTorr) and low r.f. power (10 W) are the optimal deposition conditions for fabricating IGZO thin films with improved electrical properties.

  16. Pulse Frequency Effect on Neutron Damage in -Iron: A KMC Analysis

    SciTech Connect

    Perlado, J M; Lodi, D; Dominguez, E; Ogando, F; Prieto, J; Diaz de la Rubia, T; Caturla, J

    2001-05-01

    The pulsed nature of the irradiation and the high neutron dose are the critical factors in an Inertial Fusion Energy reactor (IFE). The damage that structural materials suffer under these extremes conditions require a careful study and assessment. The goal of our work is to simulate, trough the multiscale modeling approach, the damage accumulation in {alpha}-Fe under conditions relevant to a IFE Reactor. We discuss how the pulse frequency, 1 Hz, 10 Hz, and the dose rate of 10{_} and 10{_}dpa/s affect the damage production and accumulation. Results of the damage that this demanding environment can produce on a protected first structural exposed to 150 keV average recoil ion will be presented. A further comparison it has been made with the damage produced by a continuous irradiation at similar average dose.

  17. Pulsed radio-frequency discharge inductively coupled plasma mass spectrometry for oxide analysis

    NASA Astrophysics Data System (ADS)

    Li, Weifeng; Yin, Zhibin; Hang, Wei; Li, Bin; Huang, Benli

    2016-08-01

    A direct solid sampling technique has been developed based on a pulsed radio-frequency discharge (RFD) in mixture of N2 and Ar environment at atmospheric pressure. With an averaged input power of 65 W, a crater with the diameter of 80 μm and depth of 50 μm can be formed on sample surface after discharge for 1 min, suggesting the feasibility of the pulsed RFD for sampling nonconductive solids. Combined with inductively coupled plasma mass spectrometry (ICPMS), this technique allows to measure elemental composition of solids directly with relative standard deviation (RSD) of ~ 20%. Capability of quantitative analysis was demonstrated by the use of soil standards and artificial standards. Good calibration linearity and limits of detection (LODs) in range of 10- 8-10- 9 g/g were achieved for most elements.

  18. Development of a high-frequency coaxial multi-bypass pulse tube refrigerator below 14 K

    NASA Astrophysics Data System (ADS)

    Zhou, Qiang; Chen, Liubiao; Zhu, Xiaoshuang; Zhu, Wenxiu; Zhou, Yuan; Wang, Junjie

    2015-04-01

    A high-frequency coaxial multi-bypass pulse tube refrigerator (MBPTR) was designed, manufactured, and tested. The cold finger is driven by a linear compressor through a connection tube to reduce the vibrations coming from the compressor. The pulse tube refrigerator adopts a coaxial configuration with a double-inlet and a single multi-bypass to improve the performance. With Er3Ni spheres at the cold end of the regenerator, the refrigerator can reach a no-load temperature of 13.9 K with 250 W electric input power, which is the lowest temperature for this kind of refrigerator reported so far. Especially, the interplay of double-inlet and multi-bypass was observed experimentally. An Er3Ni spheres regenerator was found to be a potential substitution for stainless steel wire mesh (SSWM) regenerator for this kind of refrigerator.

  19. Electron acceleration in relativistic plasma waves generated by a single frequency short-pulse laser

    SciTech Connect

    Coverdale, C.A.; Darrow, C.B.; Decker, C.D.; Mori, W.B.; Tzeng, K.C., Clayton, C.E.; Marsh, K.A.; Joshi, C.

    1995-04-27

    Experimental evidence for the acceleration of electrons in a relativistic plasma wave generated by Raman forward scattering (SRS-F) of a single-frequency short pulse laser are presented. A 1.053 {mu}m, 600 fsec, 5 TW laser was focused into a gas jet with a peak intensity of 8{times}10{sup 17} W/cm{sup 2}. At a plasma density of 2{times}10{sup 19} cm{sup {minus}3}, 2 MeV electrons were detected and their appearance was correlated with the anti-Stokes laser sideband generated by SRS-F. The results are in good agreement with 2-D PIC simulations. The use of short pulse lasers for making ultra-high gradient accelerators is explored.

  20. Method for Estimating Harmonic Frequency Dependence of Diffusion Coefficient and Convective Velocity in Heat Pulse Propagation Experiment

    NASA Astrophysics Data System (ADS)

    Kobayashi, Tatsuya; Itoh, Kimitaka; Ida, Katsumi; Inagaki, Sigeru; Itoh, Sanae-I.

    2017-07-01

    In this paper we propose a new set of formulae for estimating the harmonic frequency dependence of the diffusion coefficient and the convective velocity in the heat pulse propagation experiment in order to investigate the transport hysteresis. The assumptions that are used to derive the formulae can result in dummy frequency dependences of the transport coefficients. It is shown that these dummy frequency dependences of the transport coefficients can be distinguished from the true frequency dependence due to the transport hysteresis by using a bidirectional heat pulse propagation manner, in which both the outward propagating heat pulse and the inward propagating heat pulse are analyzed. The validity of the new formulae are examined in a simple numerical calculation.

  1. Central lipoprivation-induced suppression of luteinizing hormone pulses is mediated by paraventricular catecholaminergic inputs in female rats.

    PubMed

    Sajapitak, Somchai; Iwata, Kinuyo; Shahab, Mohammad; Uenoyama, Yoshihisa; Yamada, Shunji; Kinoshita, Mika; Bari, Farida Y; I'Anson, Helen; Tsukamura, Hiroko; Maeda, Kei-ichiro

    2008-06-01

    The present study aims to clarify the role of fatty acids in regulating pulsatile LH secretion in rats. To produce an acute central lipoprivic condition, mercaptoacetate (MA), an inhibitor of fatty acids oxidation, was administered into the fourth cerebroventricle (4V) in ad libitum fed ovariectomized (OVX) rats (0.4, 2, and 10 micromol/rat) with or without an estradiol (E2) implant producing diestrus plasma E2 levels. Pulsatile LH secretion was suppressed by 4V MA administration in a dose-dependent manner in both OVX and OVX plus E2 rats. Mean LH levels and LH pulse frequency and amplitude were significantly reduced by the highest dose of MA in OVX rats, and by the middle and highest dose of MA in E2-treated rats, suggesting that estrogen enhanced LH suppression. Blood glucose levels increased immediately after the highest dose of MA in both groups. Fourth ventricular injection of trimetazidine (2 and 3 micromol/rat), another inhibitor of fatty acids oxidation, also inhibited pulsatile LH release, resulting in significant and dose-dependent suppression of LH pulse frequency and an increase in blood glucose levels in OVX plus E2 rats. In contrast, peripheral injection of the highest 4V dose of MA (10 micromol/rat) did not alter LH release or blood glucose levels. Microdialysis of the hypothalamic paraventricular nucleus (PVN) revealed that norepinephrine release in the region was increased by 4V MA administration. Preinjection of alpha-methyl-p-tyrosine, a catecholamine synthesis inhibitor, into the PVN completely blocked the lipoprivic inhibition of LH and the counter-regulatory increase in blood glucose levels in OVX plus E2 rats. Together, these studies indicate that fatty acid availability may be sensed by a central detector, located in the lower brainstem to maintain reproduction, and that noradrenergic inputs to the PVN mediate this lipoprivic-induced suppression of LH release.

  2. [Retinal photocoagulation with a pulsed, frequency-doubled Nd:YAG laser (532 nm)].

    PubMed

    Roider, J; Schiller, M; el Hifnawi, E S; Birngruber, R

    1994-12-01

    The small difference in wavelength between an argon laser (514 nm) and a frequency-doubled Nd:YAG laser (532 nm), together with the advantage of the solid-state technology, makes the Nd:YAG laser likely to play a major role in retinal photocoagulation in the near future. For technical reasons all frequency-doubled Nd:YAG lasers work in a quasi-continuous mode, emitting a burst of highly repetitive short laser pulses during the exposure time desired. We investigated the side effects due to high peak irradiances of those short laser pulse trains (Crystal Focus Nd:YAG laser, Emerald; pulse duration 1-10 microseconds, repetition rate 13 KHz) in rabbits in comparison with a standard argon laser system (Zeiss, Visulas, Argon II). The energy necessary for blanching the retina was similar in both cases. As opposed to the argon laser system, subretinal bubbles were regularly visible ophthalmoscopically with the Nd:YAG system, when average powers as high as 200 mW were used. The ED50 power for bubble formation is about 2-3 times above the ED50 power for blanching. Thermal calculations show that this bubble formation effect is likely to be related to the peak power of the short pulses. The hemorrhage threshold is similar in both systems. However, light microscopically there is no difference between the two laser systems. Panretinal photocoagulation (300-500 microns, 100-200 ms) in patients with proliferative diabetic retinopathy produced such bubbles about once per 1000 lesions.

  3. Using phase retrieval to measure the intensity and phase of ultrashort pulses: Frequency-resolved optical gating

    SciTech Connect

    Trebino, R. ); Kane, D.J. )

    1993-05-01

    The authors recently introduced a new technique, frequency-resolved optical gating (FROG). For directly determining the full intensity I(t) and phase [var phi](t) of a single femtosecond pulse. By using almost any instantaneous nonlinear-optical interaction of two replicas of the ultrashort pulse to be measured, FROG involves measuring the spectrum of the signal pulse as a function of the delay between the replicas. The resulting trace of intensity versus frequency and delay yields an intuitive display of the pulse that is similar to the pulse spectrogram, except that the gate is a function of the pulse to be measured. The problem of inverting the FROG trace to obtain the pulse intensity and phase can also be considered a complex two-dimensional phase-retrieval problem. As a result, the FROG trace yields, in principle, an essentially unique pulse intensity and phase. It is shown that this is also the case in practice. An iterative-Fourier-transform algorithm is presented for inverting the FROG trace. The algorithm is unusual in its use of a novel constraint: the mathematical form of the signal field. Without the use of a support constraint, the algorithm performs quite well in practice, even for pulses with serious phase distortions and for experimental data with noise, although it occasionally stagnates when pulses with large intensity fluctuations are used. 49 refs., 15 figs.

  4. Pulse shape measurements using single shot-frequency resolved optical gating for high energy (80 J) short pulse (600 fs) laser

    SciTech Connect

    Palaniyappan, S.; Johnson, R.; Shimada, T.; Gautier, D. C.; Letzring, S.; Offermann, D. T.; Fernandez, J. C.; Shah, R. C.; Jung, D.; Hegelich, B. M.; Hoerlein, R.

    2010-10-15

    Relevant to laser based electron/ion accelerations, a single shot second harmonic generation frequency resolved optical gating (FROG) system has been developed to characterize laser pulses (80 J, {approx}600 fs) incident on and transmitted through nanofoil targets, employing relay imaging, spatial filter, and partially coated glass substrates to reduce spatial nonuniformity and B-integral. The device can be completely aligned without using a pulsed laser source. Variations of incident pulse shape were measured from durations of 613 fs (nearly symmetric shape) to 571 fs (asymmetric shape with pre- or postpulse). The FROG measurements are consistent with independent spectral and autocorrelation measurements.

  5. Design of High Frequency Pulse Tube Cryocooler for Onboard Space Applications

    NASA Astrophysics Data System (ADS)

    Srikanth, Thota; Padmanabhan; Gurudath, C. S.; Amrit, A.; Basavaraj, S.; Dinesh, K.

    2017-02-01

    To meet the growing demands of on-board applications such as cooling meteorological payloads and the satellite operational constraints like power, lower mass, reduced size and redundancy; a Pulse Tube Cryocooler (PTC) is designed by arriving at an operating frequency of 100 Hz and Helium gas pressure of 35 bar based on insights obtained from combination of phasor diagram, pulse tube and regenerator geometries with overall system mass of ≤ 2.0 kg. High frequency operation would allow reducing the size and mass of pressure wave modulator for a given input power. High Frequency also helps in reducing the volume of regenerator for a given cooling power, which increases the power density and leads to faster cool down. A component level modelling of the regenerator for optimising length and diameter for maximum Coefficient of Performance (COP) is carried out using REGEN3.3. The overall system level modelling of PTC is carried out using 1-D software SAGE. The cold end mass flow rate of the optimised regenerator is taken as reference for the system modelling. The performance achieved in REGEN3.3 is 2.15 W of net heat lift against the performance of 1.02 W of net heat lift at 80 K in SAGE.

  6. Rapid B1 mapping using orthogonal, equal-amplitude radio-frequency pulses.

    PubMed

    Chang, Yulin V

    2012-03-01

    We present a new phase-based method for mapping the amplitude of the radio-frequency field (B(1) ) of a transmitter coil in three-dimension. This method exploits the noncommutation relation between rotations about orthogonal axes. Our implementation of this principle in the current work results in a simple relation between the phase of the final magnetization and the flip angle (FA). In this study, we focus on FAs less than 90°. Our method is rapid and easy to implement compared with the existing B(1) mapping schemes. The mapping sequence can be simply obtained by adding to a regular three-dimensional gradient-echo sequence a magnetization preparation radio-frequency pulse of the same FA but orthogonal in phase to the excitation radio-frequency pulse. This method is demonstrated capable of generating reliable maps of the B(1) field within 1 min using FAs no larger than 60°. We show that it is robust against T(1), small chemical shift, and mild background inhomogeneity. This method may especially be suitable for B(1) mapping in situations (e.g., long-T(1) and hyperpolarized-gas imaging) where magnitude-based methods are not readily applicable. A noise calculation of the FA map using this method is also presented. Copyright © 2011 Wiley Periodicals, Inc.

  7. Novel high-frequency, high-power, pulsed oscillator based on a transmission line transformer.

    PubMed

    Burdt, R; Curry, R D

    2007-07-01

    Recent analysis and experiments have demonstrated the potential for transmission line transformers to be employed as compact, high-frequency, high-power, pulsed oscillators with variable rise time, high output impedance, and high operating efficiency. A prototype system was fabricated and tested that generates a damped sinusoidal wave form at a center frequency of 4 MHz into a 200 Omega load, with operating efficiency above 90% and peak power on the order of 10 MW. The initial rise time of the pulse is variable and two experiments were conducted to demonstrate initial rise times of 12 and 3 ns, corresponding to a spectral content from 4-30 and from 4-100 MHz, respectively. A SPICE model has been developed to accurately predict the circuit behavior and scaling laws have been identified to allow for circuit design at higher frequencies and higher peak power. The applications, circuit analysis, test stand, experimental results, circuit modeling, and design of future systems are all discussed.

  8. Effect of pulse duration on the acoustic frequency emissions during the laser-induced breakdown of atmospheric air.

    PubMed

    Manikanta, E; Vinoth Kumar, L; Venkateshwarlu, P; Leela, Ch; Kiran, P Prem

    2016-01-20

    Acoustic shock waves (ASWs) in the frequency range of 30-120 kHz generated during laser-induced breakdown (LIB) of ambient air using 7 ns and 30 ps pulse durations are studied. The specific frequency range and peak amplitudes are observed to be different for nanosecond (ns) and picosecond (ps) LIB. The ASW frequencies for ps-LIB lie between 90 and 120 kHz with one dominant peak, whereas for ns-LIB, two dominant peaks with frequencies in the 30-70 kHz and 80-120 kHz range are observed. These frequencies are observed to be laser pulse intensity dependent. With increasing energy of ns laser pulses, acoustic frequencies move toward the audible frequency range. The variation in the acoustic parameters, such as peak-to-peak pressures, signal energy, frequency and acoustic pulse widths as a function of laser energy, for two different pulse durations are presented in detail and compared. The acoustic emissions are observed to be higher for ns-LIB than ps-LIB, indicating higher conversion efficiency of optical energy into mechanical energy.

  9. [Low-frequency pulsed electromagnetic fields promotes rat osteoblast differentiation in vitro through cAMP/PKA signal pathway].

    PubMed

    Fang, Qing-Qing; Li, Zhi-Zhong; Zhou, Jian; Shi, Wen-Gui; Yan, Juan-Li; Xie, Yan-Fang; Chen, Ke-Ming

    2016-11-20

    To study whether low-frequency pulsed electromagnetic fields promotes the differentiation of cultured rat osteoblasts through the cAMP/PKA signal pathway. Rat calvarial osteoblasts isolated by enzyme digestion were exposed to 50 Hz 0.6 mT low-frequency pulsed electromagnetic field for varying lengths of time, and the concentration of cAMP and levels of phosphorylated PKA in the cells were assayed. In cells treated with DDA to inhibit the activity of adenylate cyclase, the changes of ALP activity and transcription of osteogenic gene were detected after exposure to low-frequency pulsed electromagnetic field. The changes of osteogenic gene transcription and protein expression were tested in the osteoblasts pretreated with KT5720 in response to low-frequency pulsed electromagnetic field exposure. The intracellular cAMP concentration in the cells increased significantly at 20 min during exposure to low-frequency pulsed electromagnetic field, began to decrease at 40 min during the exposure, and increased again after a 2-h exposure; the same pattern of variation was also observed in p-PKA level. Application of DDA and KT5720 pretreatment both suppressed the increase in ALP activity and osteogenic gene transcription induced by electromagnetic field exposure. Low- frequency pulsed electromagnetic field exposure improves the differentiation of cultured rat osteoblasts by activating cAMP/PKA signal pathway.

  10. Phonotactic selectivity in two cryptic species of gray treefrogs: effects of differences in pulse rate, carrier frequency and playback level.

    PubMed

    Gerhardt, H Carl

    2008-08-01

    The two main spectral components of the advertisement calls of two species of North American gray treefrogs (Hyla chrysoscelis and H. versicolor) overlap broadly in frequency, and the frequency of each component matches the sensitivity of one of the two different auditory inner ear organs. The calls of the two species differ in the shape and repetition rate (pulse rate) of sound pulses within trills. Standard synthetic calls with one of these spectral peaks and the pulse rate typical of conspecific calls were tested against synthetic alternatives that had the same spectral peak but a different pulse rate. The results were generalized over a wide range of playback levels. Selectivity based on differences in pulse rate depended on which spectral peak was used in some tests, and greater pulse-rate selectivity was usually observed when the low-frequency rather than the high-frequency peak was used. This effect was more pronounced and occurred over a wider range of playback levels in H. versicolor than in H. chrysoscelis when the pulse rate of the alternative was higher than that of the standard call. In tests at high playback levels with an alternative of 15 pulses s(-1), however, females of H. versicolor showed greater selectivity for the standard call when the high-frequency rather than the low-frequency spectral peak was used. This last result may reflect the different ways in which females of the two species assess trains of pulses, and the broad implications for understanding the underlying auditory mechanisms are discussed.

  11. Self-focusing and frequency broadening of laser pulse in water

    SciTech Connect

    Sati, Priti; Tripathi, V. K.; Verma, Updesh

    2014-11-15

    An analytical model for the avalanche breakdown of water by an intense short laser pulse of finite spot size is developed. Initially, the laser undergoes self-focusing due to Kerr nonlinearity. As it acquires large intensity, it causes heating and avalanche breakdown of water. The plasma thus created on the laser axis causes nonlinear refraction induced defocusing of the laser. Thermal conduction tends to flatten the temperature profile and reduce the nonlinear refraction. The plasma density modification leads to frequency broadening of the laser.

  12. Dual Frequency Band Annular Probe for Volumetric Pulse-echo Optoacoustic Imaging

    NASA Astrophysics Data System (ADS)

    Kalkhoran, Mohammad Azizian; Varray, François; Vray, Didier

    Optoacoustic (OA) pulse echo (PE) imaging is a hybridized modality that is capable of providing physiological information on the basis of anatomical structure. In this work, we propose a dual frequency band annular probe for backward mode volumetric PE/OA imaging. The performance of this design is evaluated based on the spatio-temporal impulse response, three dimensional steerability of the transducer and point spread function. Optimum settings for number of elements in each ring and maximum steering are suggested. The transducer design and synthetic array beamforming simulation are presented. The resolution performance and reconstruction capabilities are shown with the in-silico measurements.

  13. Pulse retrieval in frequency-resolved optical gating based on the method of generalized projections

    SciTech Connect

    DeLong, K.W.; Fittinghoff, D.N.; Trebino, R. ); Kohler, B.; Wilson, K. )

    1994-12-15

    We use the algorithmic method of generalized projections (GP's) to retrieve the intensity and phase of an ultrashort laser pulse from the experimental trace in frequency-resolved optical gating (FROG). Using simulations, we show that the use of GP's improves significantly the convergence properties of the algorithm over the basic FROG algorithm. In experimental measurements, the GP-based algorithm achieves significantly lower errors than previous algorithms. The use of GP's also permits the inclusion of an arbitrary material response function in the FROG problem.

  14. Interference-induced transparency and coherent control of quantum systems by frequency-chirped pulses

    NASA Astrophysics Data System (ADS)

    Nazarkin, A.; Netz, R.; Sauerbrey, R.

    2003-04-01

    A selective excitation technique based on light interference is proposed to control quantum systems by frequency-chirped laser fields. Interference of two identical, delayed and phase-shifted pulses is used to modulate the laser spectrum and project it onto the time domain. By adjusting the delay and phase shift, selected transitions can be brought into the “holes” of the spectrum and thus remain nonexcited. The possibility to selectively manipulate or even “shut down” resonant transitions, making the medium transparent to the field, is shown for the Rb atom.

  15. Effects of low frequency pulsed electrical current on keratinocytes in vitro

    SciTech Connect

    Hinsenkamp, M.; Jercinovic, A.

    1997-05-01

    The effects of low frequency pulsed electrical current on epidermal repair in vitro were examined. Charge-balanced current stimuli proposed for chronic wound treatment were tested on skin keratinocytes cultured at an air-liquid interface on dead human dermis. Results imply that the balance between proliferation and differentiation in electrically treated samples is significantly modified in favor of differentiation. More advanced differentiation, shown through epidermal histology, was obtained in cultures exposed to electrical current, whereas the culture growth, the result of keratinocyte migration and proliferation, was greater in control samples.

  16. Generation of a sequence of frequency-modulated pulses in longitudinally inhomogeneous optical waveguides

    NASA Astrophysics Data System (ADS)

    Zolotovskii, I. O.; Lapin, V. A.; Sementsov, D. I.; Stolyarov, D. A.

    2017-03-01

    The conditions for the generation and efficient amplification of frequency-modulated soliton-like wave packets in longitudinally inhomogeneous active optical waveguides have been studied. The possibility of forming a sequence of pico- and subpicosecond pulses from quasi-continuous radiation in active and passive optical waveguides with the group-velocity dispersion (GVD) changing over the waveguide length is considered. The behavior of a wave packet in the well-developed phase of modulation instability with a change in the waveguide inhomogeneity parameters has been investigated based on the numerical analysis.

  17. Effects of low-frequency pulsed electromagnetic fields on plateau frostbite healing in rats.

    PubMed

    Jiao, Mingke; Lou, Lin; Jiao, Lin; Hu, Jie; Zhang, Peng; Wang, Zhongming; Xu, Wenjuan; Geng, Xiliang; Song, Hongping

    2016-11-01

    Plateau frostbite (PF) treatments have remained a clinical challenge because this condition injures tissues in deep layers and affected tissues exhibit unique pathological characteristics. For instance, low-frequency pulsed electromagnetic field (PEMF) can affect tissue restoration and penetrate tissues. Therefore, the effect of PEMF on PF healing should be investigated. This study aimed to evaluate the effects of low-frequency PEMF on PF healing systematically. Ninety-six Sprague-Dawley rats were randomly and equally divided into three groups: normal control, partial thickness plateau frostbite (PTPF), and PTPF with low-frequency PEMF exposure (PTPF + PEMF). PTPF wounds were induced in the dorsum of the rats. The PTPF + PEMF group was exposed to low-frequency PEMF daily. During PF healing, wound microcirculation in each group was monitored through contrast ultrasonography. Wound appearance, histological observation, and wound tensile strength were also evaluated. Results showed that the rate of the microcirculation restoration of the PTPF + PEMF group was nearly 25% faster than that of the PTPF group, and wound appearance suggested that the healing of the PTPF group was slower than that of the PTPF + PEMF group. Histological observation revealed that PEMF accelerated the growth of different deep tissues, as confirmed by tensile strength examination. Low-frequency PEMF could penetrate PF tissues, promote their restoration, and provide a beneficial effect on PF healing. Therefore, this technique may be a potential alternative to treat PF. © 2016 by the Wound Healing Society.

  18. Atomic fountain clock with very high frequency stability employing a pulse-tube-cryocooled sapphire oscillator.

    PubMed

    Takamizawa, Akifumi; Yanagimachi, Shinya; Tanabe, Takehiko; Hagimoto, Ken; Hirano, Iku; Watabe, Ken-ichi; Ikegami, Takeshi; Hartnett, John G

    2014-09-01

    The frequency stability of an atomic fountain clock was significantly improved by employing an ultra-stable local oscillator and increasing the number of atoms detected after the Ramsey interrogation, resulting in a measured Allan deviation of 8.3 × 10(-14)τ(-1/2)). A cryogenic sapphire oscillator using an ultra-low-vibration pulse-tube cryocooler and cryostat, without the need for refilling with liquid helium, was applied as a local oscillator and a frequency reference. High atom number was achieved by the high power of the cooling laser beams and optical pumping to the Zeeman sublevel m(F) = 0 employed for a frequency measurement, although vapor-loaded optical molasses with the simple (001) configuration was used for the atomic fountain clock. The resulting stability is not limited by the Dick effect as it is when a BVA quartz oscillator is used as the local oscillator. The stability reached the quantum projection noise limit to within 11%. Using a combination of a cryocooled sapphire oscillator and techniques to enhance the atom number, the frequency stability of any atomic fountain clock, already established as primary frequency standard, may be improved without opening its vacuum chamber.

  19. Phase calibration of sonar systems using standard targets and dual-frequency transmission pulses.

    PubMed

    Islas-Cital, Alan; Atkins, Philip R; Foo, Kae Y; Picó, Ruben

    2011-10-01

    The phase angle component of the complex frequency response of a sonar system operating near transducer resonance is usually distorted. Interpretation and classification of the received sonar signal benefits from the preservation of waveform fidelity over the full bandwidth. A calibration process that measures the phase response in addition to the amplitude response is thus required. This paper describes an extension to the standard-target calibration method to include phase angle, without affecting the experimental apparatus, by using dual-frequency transmission pulses and frequency-domain data processing. This approach reduces the impact of unknown range and sound speed parameters upon phase calibration accuracy, as target phase is determined from the relationship of the two frequency components instead of relying on a local phase reference. Tungsten carbide spheres of various sizes were used to simultaneously calibrate the amplitude and phase response of an active sonar system in a laboratory tank. Experimental measurements of target phase spectra are in good agreement with values predicted from a theoretical model based upon full-wave analysis, over an operating frequency of 50-125 kHz.

  20. Reduced pulse energy for frequency comb offset stabilization with a dual-pitch periodically poled lithium niobate ridge waveguide

    NASA Astrophysics Data System (ADS)

    Hitachi, K.; Hara, K.; Tadanaga, O.; Ishizawa, A.; Nishikawa, T.; Gotoh, H.

    2017-06-01

    The pulse energy for stabilizing the carrier-envelop offset frequency of an Er-doped fiber laser was reduced by a dual-pitch (DP-) periodically poled lithium niobate (PPLN) ridge waveguide implemented in a 2f-to-3f self-referencing interferometer (SRI). The pulse energy requirement was less than half that for a single-pitch PPLN ridge waveguide implemented in an f-to-2f SRI. We also found that environmental noise could be reduced by adjusting the pulse energy for frequency stabilization with the DP-PPLN ridge waveguide, as estimated from the phase noise of an out-of-loop interferometer.

  1. Properties of High-Frequency Sub-Wavelength Ripples on Stainless Steel 304L under Ultra Short Pulse Laser Irradiation

    NASA Astrophysics Data System (ADS)

    Mitko, V. S.; Römer, G. R. B. E.; Veld, A. J. Huis in `t.; Skolski, J. Z. P.; Obona, J. V.; Ocelík, V.; De Hosson, J. T. M.

    The paper concentrates on surface texturing on sub-micro meter scale with ultra short laser pulses that has several applications, e.g. changing the hydrophilic/hydrophobic performance, optical or tribological properties of materials. In general, the formations of wavy structures, or ripples on a surface irradiated by short pulse lasers has been observed experimentally since 1965, and are usually referred to as Laser Induced Periodic Surface Structures (LIPSS). Generally Low Spatial Frequency LIPSS (LSFL) and High Spatial Frequency LIPSS (HSFL) are observed. The existing theoretical models do not describe the origin, nor growth of the ripples satisfactorily. That is why the experimental approach still plays a leading role in the investigation of ripple formation. In this paper we study the development of HSFL and LSFL as a result of picosecond laser pulses on a surface of stainless steel. Influences of number of pulses and pulse overlap on ripples growth were examined.

  2. Copper bromide vapor brightness amplifiers with 100 kHz pulse repetition frequency

    NASA Astrophysics Data System (ADS)

    Trigub, M. V.; Evtushenko, G. S.; Torgaev, S. N.; Shiyanov, D. V.; Evtushenko, T. G.

    2016-10-01

    The paper presents a laser monitor with 10 μs time-resolution based on a high-frequency copper bromide vapor brightness amplifier. A sync circuit has been designed for single-pulse imaging. The analysis of amplifying characteristics of the active elements and active optical system (laser monitor) parameters allowed to determine the optimal concentration of HBr at which the images can be obtained with minimum distortions. For the active element operating at high frequencies (more than 50 kHz) as a brightness amplifier, the concentration of HBr must be lower than that needed for obtaining the maximum output power. The limiting brightness temperature of the background radiation which does not affect the image quality is determined. The potential feasibility of using a proposed brightness amplifier for visualizing processes blocked from viewing by the background radiation with the brightness temperature up to 8000 K is demonstrated.

  3. Formation of high spatial frequency ripples in stainless steel irradiated by femtosecond laser pulses in water

    NASA Astrophysics Data System (ADS)

    Huo, Yanyan; Jia, Tianqing; Feng, Donghai; Zhang, Shian; Liu, Jukun; Pan, Jia; Zhou, Kan; Sun, Zhenrong

    2013-05-01

    We report the formation of high spatial frequency ripples (HSFRs) in stainless steel irradiated by 50 fs, 800 nm, 1 kHz femtosecond laser pulses in water. The period of the HSFRs, Λ, is less than 0.2λ, where λ is the laser wavelength. We further conduct theoretical calculations to study the ultrafast dynamics, and find that double splitting of the low spatial frequency ripples (LSFRs, Λ > 0.45λ) plays a decisive role in the formation of HSFRs. Similar experiments are conducted in copper, however, no splitting of LSFRs is observed. The different experimental results on stainless steel and copper conducted in water and in air are also discussed.

  4. Practical issues in ultrashort-laser-pulse measurement using frequency-resolved optical gating

    SciTech Connect

    DeLong, K.W.; Fittinghoff, D.N.; Trebino, R.

    1996-07-01

    The authors explore several practical experimental issues in measuring ultrashort laser pulses using the technique of frequency-resolved optical gating (FROG). They present a simple method for checking the consistency of experimentally measured FROG data with the independently measured spectrum and autocorrelation of the pulse. This method is a powerful way of discovering systematic errors in FROG experiments. They show how to determine the optimum sampling rate for FROG and show that this satisfies the Nyquist criterion for the laser pulse. They explore the low- and high-power limits to FROG and determine that femtojoule operation should be possible, while the effects of self-phase modulation limit the highest signal efficiency in FROG to 1%. They also show quantitatively that the temporal blurring due to a finite-thickness medium in single-shot geometries does not strongly limit the FROG technique. They explore the limiting time-bandwidth values that can be represented on a FROG trace of a given size. Finally, they report on a new measure of the FROG error that improves convergence in the presence of noise.

  5. NMR spin locking of proton magnetization under a frequency-switched Lee-Goldburg pulse sequence.

    PubMed

    Fu, Riqiang; Tian, Changlin; Cross, Timothy A

    2002-01-01

    The spin dynamics of NMR spin locking of proton magnetization under a frequency-switched Lee-Goldburg (FSLG) pulse sequence is investigated for a better understanding of the line-narrowing mechanism in PISEMA experiments. For the sample of oriented 15N(1,3,5,7)-labeled gramicidin A in hydrated DMPC bilayers, it is found that the spin-lattice relaxation time T(1rho)(H) in the tilted rotating frame is about five times shorter when the 1H magnetization is spin locked at the magic angle by the FSLG sequence compared to the simple Lee-Goldburg sequence. It is believed that the rapid phase alternation of the effective fields during the FSLG cycles results in averaging of the spin lock field so that the spin lock becomes less efficient. A FSLG supercycle has been suggested here to slow the phase alternation. It has been demonstrated experimentally that a modified PISEMA pulse sequence with such supercycles gives rise to about 30% line narrowing in the dipolar dimension in the PISEMA spectra compared to a standard PISEMA pulse sequence.

  6. Effect of overpressure and pulse repetition frequency on cavitation in shock wave lithotripsy.

    PubMed

    Sapozhnikov, Oleg A; Khokhlova, Vera A; Bailey, Michael R; Williams, James C; McAteer, James A; Cleveland, Robin O; Crum, Lawrence A

    2002-09-01

    Cavitation appears to contribute to tissue injury in lithotripsy. Reports have shown that increasing pulse repetition frequency [(PRF) 0.5-100 Hz] increases tissue damage and increasing static pressure (1-3 bar) reduces cell damage without decreasing stone comminution. Our hypothesis is that overpressure or slow PRF causes unstabilized bubbles produced by one shock pulse to dissolve before they nucleate cavitation by subsequent shock pulses. The effects of PRF and overpressure on bubble dynamics and lifetimes were studied experimentally with passive cavitation detection, high-speed photography, and B-mode ultrasound and theoretically. Overpressure significantly reduced calculated (100-2 s) and measured (55-0.5 s) bubble lifetimes. At 1.5 bar static pressure, a dense bubble cluster was measured with clinically high PRF (2-3 Hz) and a sparse cluster with clinically low PRF (0.5-1 Hz), indicating bubble lifetimes of 0.5-1 s, consistent with calculations. In contrast to cavitation in water, high-speed photography showed that overpressure did not suppress cavitation of bubbles stabilized on a cracked surface. These results suggest that a judicious use of overpressure and PRF in lithotripsy could reduce cavitation damage of tissue while maintaining cavitation comminution of stones.

  7. Effect of frequency characteristic of excitation pulse on lateral spatial resolution in coded ultrasound imaging

    NASA Astrophysics Data System (ADS)

    Fujita, Hiroki; Hasegawa, Hideyuki

    2017-07-01

    Recently, portable ultrasonic diagnostic equipment has frequently been used in clinical situations. The use of portable ultrasonic diagnostic equipment expands various diagnosis areas, such as remote medical diagnosis, and emergent diagnosis at disaster. It is expected that portable ultrasonic diagnostic equipment will be used more frequently in the future. To make ultrasonic diagnostic equipment portable, the number of transducer elements in an ultrasonic probe should be reduced significantly. Therefore, the transmit-receive sensitivity of the ultrasonic probe is degraded. For the improvement of the signal-to-noise ratio (SNR) of the received ultrasonic echo, coded excitation was introduced in ultrasonic imaging. Owing to pulse compression applied to the received echo signal, its SNR significantly improved without the degradation of the range spatial resolution. However, the lateral spatial resolution in coded ultrasound imaging has not been investigated in previous studies. The present study showed that the lateral resolution in coded ultrasound imaging using a typical code, 5-bit Barker code, was worse than that using a conventional short pulse. Such degradation was discussed in terms of the frequency characteristics of the impulse response of the ultrasonic transducer and the excitation pulse. Also, the Gaussian phase coherence factor was introduced as one of the methods to overcome such degradation in lateral spatial resolution.

  8. The effect of applied electric field on pulsed radio frequency and pulsed direct current plasma jet array

    SciTech Connect

    Hu, J. T.; Liu, X. Y.; Liu, J. H.; Xiong, Z. L.; Liu, D. W.; Lu, X. P.; Iza, F.; Kong, M. G.

    2012-06-15

    Here we compare the plasma plume propagation characteristics of a 3-channel pulsed RF plasma jet array and those of the same device operated by a pulsed dc source. For the pulsed-RF jet array, numerous long life time ions and metastables accumulated in the plasma channel make the plasma plume respond quickly to applied electric field. Its structure similar as 'plasma bullet' is an anode glow indeed. For the pulsed dc plasma jet array, the strong electric field in the vicinity of the tube is the reason for the growing plasma bullet in the launching period. The repulsive forces between the growing plasma bullets result in the divergence of the pulsed dc plasma jet array. Finally, the comparison of 309 nm and 777 nm emissions between these two jet arrays suggests the high chemical activity of pulsed RF plasma jet array.

  9. Pulsing frequency induced change in optical constants and dispersion energy parameters of WO{sub 3} films grown by pulsed direct current magnetron sputtering

    SciTech Connect

    Punitha, K.; Sivakumar, R.; Sanjeeviraja, C.

    2014-03-21

    In this work, we present the pulsing frequency induced change in the structural, optical, vibrational, and luminescence properties of tungsten oxide (WO{sub 3}) thin films deposited on microscopic glass and fluorine doped tin oxide (SnO{sub 2}:F) coated glass substrates by pulsed dc magnetron sputtering technique. The WO{sub 3} films deposited on SnO{sub 2}:F substrate belongs to monoclinic phase. The pulsing frequency has a significant influence on the preferred orientation and crystallinity of WO{sub 3} film. The maximum optical transmittance of 85% was observed for the film and the slight shift in transmission threshold towards higher wavelength region with increasing pulsing frequency revealed the systematic reduction in optical energy band gap (3.78 to 3.13 eV) of the films. The refractive index (n) of films are found to decrease (1.832 to 1.333 at 550 nm) with increasing pulsing frequency and the average value of extinction coefficient (k) is in the order of 10{sup −3}. It was observed that the dispersion data obeyed the single oscillator of the Wemple-Didomenico model, from which the dispersion energy (E{sub d}) parameters, dielectric constants, plasma frequency, oscillator strength, and oscillator energy (E{sub o}) of WO{sub 3} films were calculated and reported for the first time due to variation in pulsing frequency during deposition by pulsed dc magnetron sputtering. The E{sub o} is change between 6.30 and 3.88 eV, while the E{sub d} varies from 25.81 to 7.88 eV, with pulsing frequency. The Raman peak observed at 1095 cm{sup −1} attributes the presence of W-O symmetric stretching vibration. The slight shift in photoluminescence band is attributed to the difference in excitons transition. We have made an attempt to discuss and correlate these results with the light of possible mechanisms underlying the phenomena.

  10. Transformation of the frequency-modulated continuous-wave field into a train of short pulses by resonant filters

    NASA Astrophysics Data System (ADS)

    Shakhmuratov, R. N.

    2017-03-01

    The resonant filtering method transforming the frequency-modulated radiation field into a train of short pulses is proposed to be applied in the optical domain. Effective frequency modulation can be achieved by using an electro-optic modulator. Due to frequency modulation, a narrow-spectrum cw radiation field is seen by the resonant filter as a comb of equidistant spectral components separated by the modulation frequency. Tuning a narrow-bandwidth filter in resonance with the n th spectral component of the comb transforms the radiation field into bunches of pulses, with n pulses in each bunch. The transformation is explained by the interference of the coherently scattered resonant component of the field with the whole comb. Constructive interference results in the formation of pulses, while destructive interference is seen as dark windows between pulses. It is indicated that the optimal thickness of the resonant filter is several orders of magnitude smaller than the necessary thickness of the dispersive filters used before in the optical domain to produce short pulses from the frequency-modulated field.

  11. Low-emittance electron-beam generation with laser pulse shaping in photocathode radio-frequency gun

    NASA Astrophysics Data System (ADS)

    Yang, J.; Sakai, F.; Yanagida, T.; Yorozu, M.; Okada, Y.; Takasago, K.; Endo, A.; Yada, A.; Washio, M.

    2002-08-01

    A technique of laser-pulse shaping was developed for low-emittance electron-beam generation in a photocathode radio-frequency (rf) gun. The emittance growth due to space charge and rf effects in the rf gun was experimentally investigated with square and gaussian temporal pulse shapes. It was found that the square pulse shaping was a useful tool for both the reduction of nonlinear space-charge force and the correction of linear space charge. The normalized transverse rms emittance at 1 nC was obtained to be 1.20 pimm-mrad for the square pulse shape with pulse length of 9 ps full width at half maximum. The emittance was measured as a function of the electron bunch charge and the laser-pulse length.

  12. Effects of RFamide-related peptide-3(RFRP-3) on secretion of LH in ovariectomized prepubertal gilts

    USDA-ARS?s Scientific Manuscript database

    Pulses of LH are suppressed prior to puberty in the gilt. RFRP-3 is proposed to be a hypophysiotropic hormone in mammals. A series of experiments (EXP) were conducted to test the hypothesis that RFRP-3 inhibits LH release in ovariectomized (OVX) prepubertal gilts. All gilts were OVX at least two wee...

  13. Studies of Operating Frequency Effects On Ejector-based Thrust Augmentation in a Pulse Detonation Engine

    NASA Technical Reports Server (NTRS)

    Landry, K.

    2005-01-01

    Studies were performed in order to characterize the thrust augmentation potential of an ejector in a Pulse Detonation Engine application. A 49-mm diameter tube of 0.914-m length was constructed with one open end and one closed end. Ethylene, oxygen, and nitrogen were introduced into the tube at the closed end through the implementation of a fast mixing injector. The tube was completely filled with a stoichiometric mixture containing a one to one molar ratio of nitrogen to oxygen. Ethylene was selected as the fuel due to its detonation sensitivity and the molar ratio of the oxidizer was chosen for heat transfer purposes. Detonations were initiated in the tube through the use of a spark ignition system. The PDE was operated in a multi-cycle mode at frequencies ranging from 20-Hz to 50-Hz. Baseline thrust measurements with no ejector present were performed while operating the engine at various frequencies and compared to theoretical estimates. The baseline values were observed to agree with the theoretical model at low operating frequencies and proved to be increasingly lower than the predicted values as the operating frequency was increased. The baseline thrust measurements were observed to agree within 15 percent of the model for all operating frequencies. A straight 152-mm diameter ejector was installed and thrust augmentation percentages were measured. The length of the ejector was varied while the overlap percentage (percent of the ejector length which overlapped the tube) was maintained at 25 percent for all tests. In addition, the effect of ejector inlet geometry was investigated by comparing results with a straight inlet to those of a 38-mm inlet diameter. The thrust augmentation of the straight inlet ejector proved to be independent of engine operating frequency, augmenting thrust by 40 percent for the 0.914-m length ejector. In contrast, the rounded lip ejector of the same length seemed to be highly dependent on the engine operating frequency. An optimum

  14. Studies of Operating Frequency Effects On Ejector-based Thrust Augmentation in a Pulse Detonation Engine

    NASA Technical Reports Server (NTRS)

    Landry, K.

    2005-01-01

    Studies were performed in order to characterize the thrust augmentation potential of an ejector in a Pulse Detonation Engine application. A 49-mm diameter tube of 0.914-m length was constructed with one open end and one closed end. Ethylene, oxygen, and nitrogen were introduced into the tube at the closed end through the implementation of a fast mixing injector. The tube was completely filled with a stoichiometric mixture containing a one to one molar ratio of nitrogen to oxygen. Ethylene was selected as the fuel due to its detonation sensitivity and the molar ratio of the oxidizer was chosen for heat transfer purposes. Detonations were initiated in the tube through the use of a spark ignition system. The PDE was operated in a multi-cycle mode at frequencies ranging from 20-Hz to 50-Hz. Baseline thrust measurements with no ejector present were performed while operating the engine at various frequencies and compared to theoretical estimates. The baseline values were observed to agree with the theoretical model at low operating frequencies and proved to be increasingly lower than the predicted values as the operating frequency was increased. The baseline thrust measurements were observed to agree within 15 percent of the model for all operating frequencies. A straight 152-mm diameter ejector was installed and thrust augmentation percentages were measured. The length of the ejector was varied while the overlap percentage (percent of the ejector length which overlapped the tube) was maintained at 25 percent for all tests. In addition, the effect of ejector inlet geometry was investigated by comparing results with a straight inlet to those of a 38-mm inlet diameter. The thrust augmentation of the straight inlet ejector proved to be independent of engine operating frequency, augmenting thrust by 40 percent for the 0.914-m length ejector. In contrast, the rounded lip ejector of the same length seemed to be highly dependent on the engine operating frequency. An optimum

  15. Frequency doubled high-power disk lasers in pulsed and continuous-wave operation

    NASA Astrophysics Data System (ADS)

    Weiler, Sascha; Hangst, Alexander; Stolzenburg, Christian; Zawischa, Ivo; Sutter, Dirk; Killi, Alexander; Kalfhues, Steffen; Kriegshaeuser, Uwe; Holzer, Marco; Havrilla, David

    2012-03-01

    The disk laser with multi-kW output power in infrared cw operation is widely used in today's manufacturing, primarily in the automotive industry. The disk technology combines high power (average and/or peak power), excellent beam quality, high efficiency and high reliability with low investment and operating costs. Additionally, the disk laser is ideally suited for frequency conversion due to its polarized output with negligible depolarization losses. Laser light in the green spectral range (~515 nm) can be created with a nonlinear crystal. Pulsed disk lasers with green output of well above 50 W (extracavity doubling) in the ps regime and several hundreds of Watts in the ns regime with intracavity doubling are already commercially available whereas intracavity doubled disk lasers in continuous wave operation with greater than 250 W output are in test phase. In both operating modes (pulsed and cw) the frequency doubled disk laser offers advantages in existing and new applications. Copper welding for example is said to show much higher process reliability with green laser light due to its higher absorption in comparison to the infrared. This improvement has the potential to be very beneficial for the automotive industry's move to electrical vehicles which requires reliable high-volume welding of copper as a major task for electro motors, batteries, etc.

  16. Wire Arc Additive Manufacturing of AZ31 Magnesium Alloy: Grain Refinement by Adjusting Pulse Frequency.

    PubMed

    Guo, Jing; Zhou, Yong; Liu, Changmeng; Wu, Qianru; Chen, Xianping; Lu, Jiping

    2016-10-09

    Wire arc additive manufacturing (WAAM) offers a potential approach to fabricate large-scale magnesium alloy components with low cost and high efficiency, although this topic is yet to be reported in literature. In this study, WAAM is preliminarily applied to fabricate AZ31 magnesium. Fully dense AZ31 magnesium alloy components are successfully obtained. Meanwhile, to refine grains and obtain good mechanical properties, the effects of pulse frequency (1, 2, 5, 10, 100, and 500 Hz) on the macrostructure, microstructure and tensile properties are investigated. The results indicate that pulse frequency can result in the change of weld pool oscillations and cooling rate. This further leads to the change of the grain size, grain shape, as well as the tensile properties. Meanwhile, due to the resonance of the weld pool at 5 Hz and 10 Hz, the samples have poor geometry accuracy but contain finer equiaxed grains (21 μm) and exhibit higher ultimate tensile strength (260 MPa) and yield strength (102 MPa), which are similar to those of the forged AZ31 alloy. Moreover, the elongation of all samples is above 23%.

  17. Dose rate effect of pulsed electron beam on micronucleus frequency in human peripheral blood lymphocytes.

    PubMed

    Acharya, Santhosh; Sanjeev, Ganesh; Bhat, Nagesh N; Narayana, Yerol

    2010-03-01

    The micronucleus assay in human peripheral blood lymphocytes is a sensitive indicator of radiation damage and could serve as a biological dosimeter in evaluating suspected overexposure to ionising radiation. Micronucleus (MN) frequency as a measure of chromosomal damage has also extensively been employed to quantify the effects of radiation dose rate on biological systems. Here we studied the effects of 8 MeV pulsed electron beam emitted by Microtron electron accelerator on MN induction at dose rates between 35 Gy min-1 and 352.5 Gy min-1. These dose rates were achieved by varying the pulse repetition rate (PRR). Fricke dosimeter was employed to measure the absorbed dose at different PRR and to ensure uniform dose distribution of the electron beam. To study the dose rate effect, blood samples were irradiated to an absorbed dose of (4.7+/-0.2) Gy at different rates and cytogenetic damage was quantified using the micronucleus assay. The obtained MN frequency showed no dose rate dependence within the studied dose rate range. Our earlier dose effect study using 8 MeV electrons revealed that the response of MN was linear-quadratic. Therefore, in the event of an accident, dose estimation can be made using linear-quadratic dose response parameters, without adding dose rate as a correction factor.

  18. Comparison of pulse rate variability and heart rate variability for high frequency content estimation.

    PubMed

    Logier, R; De Jonckheere, J; Dassonneville, A; Jeanne, M

    2016-08-01

    Heart Rate Variability (HRV) analysis can be of precious help in most of clinical situations because it is able to quantify the Autonomic Nervous System (ANS) activity. The HRV high frequency (HF) content, related to the parasympathetic tone, reflects the ANS response to an external stimulus responsible of pain, stress or various emotions. We have previously developed the Analgesia Nociception Index (ANI), based on HRV high frequency content estimation, which quantifies continuously the vagal tone in order to guide analgesic drug administration during general anesthesia. This technology has been largely validated during the peri-operative period. Currently, ANI is obtained from a specific algorithm analyzing a time series representing successive heart periods measured on the electrocardiographic (ECG) signal. In the perspective of widening the application fields of this technology, in particular for homecare monitoring, it has become necessary to simplify signal acquisition by using e.g. a pulse plethysmographic (PPG) sensor. Even if Pulse Rate Variability (PRV) analysis issued from PPG sensors has been shown to be unreliable and a bad predictor of HRV analysis results, we have compared PRV and HRV both estimated by ANI as well as HF and HF/(HF+LF) spectral analysis on both signals.

  19. "Ultrathin" DSAEK tissue prepared with a low-pulse energy, high-frequency femtosecond laser.

    PubMed

    Phillips, Paul M; Phillips, Louis J; Saad, Hisham A; Terry, Mark A; Stolz, Donna B; Stoeger, Christopher; Franks, Jonathan; Davis-Boozer, David

    2013-01-01

    To evaluate the endothelial cell survival and stromal bed quality when creating deep stromal cuts with a low-pulse energy, high-frequency femtosecond laser to produce "ultrathin" tissue for Descemet stripping automated endothelial keratoplasty. Seventeen corneas were used for this study. Five corneas were cut with the laser at a depth of 420 to 500 μm to produce a tissue thickness of approximately ≤70 μm. Five corneas served as an uncut comparison group. Vital dye staining and computer digitized planimetry analysis were performed on these corneas. The 7 remaining corneas were cut for scanning electron microscopy evaluation. The mean central posterior stromal thickness of cut corneas was 60.6 μm (range, 43-72 μm). Endothelial cell damage in cut and comparison corneas was 3.92% ± 2.22% (range, 1.71%-6.51%) and 4.15% ± 2.64% (range, 1.21%-7.01%), respectively (P = 0.887). Low-magnification (×12) scanning electron microscopy revealed a somewhat irregular-appearing surface with concentric rings peripherally. Qualitative grading of higher magnification (×50) central images resulted in an average score of 2.56 (between smooth and rough). Ultrathin tissue for Descemet stripping automated endothelial keratoplasty can be safely prepared with minimal endothelial cell damage using a low-pulse energy, high-frequency femtosecond laser; however, the resulting stromal surface quality may not be optimal with this technique.

  20. Wire Arc Additive Manufacturing of AZ31 Magnesium Alloy: Grain Refinement by Adjusting Pulse Frequency

    PubMed Central

    Guo, Jing; Zhou, Yong; Liu, Changmeng; Wu, Qianru; Chen, Xianping; Lu, Jiping

    2016-01-01

    Wire arc additive manufacturing (WAAM) offers a potential approach to fabricate large-scale magnesium alloy components with low cost and high efficiency, although this topic is yet to be reported in literature. In this study, WAAM is preliminarily applied to fabricate AZ31 magnesium. Fully dense AZ31 magnesium alloy components are successfully obtained. Meanwhile, to refine grains and obtain good mechanical properties, the effects of pulse frequency (1, 2, 5, 10, 100, and 500 Hz) on the macrostructure, microstructure and tensile properties are investigated. The results indicate that pulse frequency can result in the change of weld pool oscillations and cooling rate. This further leads to the change of the grain size, grain shape, as well as the tensile properties. Meanwhile, due to the resonance of the weld pool at 5 Hz and 10 Hz, the samples have poor geometry accuracy but contain finer equiaxed grains (21 μm) and exhibit higher ultimate tensile strength (260 MPa) and yield strength (102 MPa), which are similar to those of the forged AZ31 alloy. Moreover, the elongation of all samples is above 23%. PMID:28773944

  1. Simultaneous optimization of power and duration of radio-frequency pulse in PARACEST MRI.

    PubMed

    Rezaeian, Mohammad-Reza; Hossein-Zadeh, Gholam-Ali; Soltanian-Zadeh, Hamid

    2016-07-01

    Chemical exchange saturation transfer (CEST) MRI is increasingly used to probe mobile proteins and microenvironment properties, and shows great promise for tumor and stroke diagnosis. The CEST effect is complex and depends not only on the CEST agent concentration, exchange rates, the characteristic of the magnetization transfer (MT), and the relaxation properties of the tissue, but also varies with the experimental conditions such as radio-frequency (RF) pulse power and duration. The RF pulse is one of the most important factors that promote the CEST effect for biological properties such as pH, temperature and protein content, especially for contrast agents with intermediate to fast exchange rates. The CEST effect is susceptible to the RF duration and power. The present study aims at determining the optimal power and the corresponding optimal duration (that maximize the CEST effect) using an off-resonance scheme through a new definition of the CEST effect. This definition is formulated by solving the Bloch-McConnell equation through the R1ρ method (based on the eigenspace solution) for both of the MT and CEST effects as well as their interactions. The proposed formulations of the optimal RF pulse power and duration are the first formulations in which the MT effect is considered. The extracted optimal RF pulse duration and power are compared with those of the MTR asymmetry model in two- and three-pool systems, using synthetic data that are similar to the muscle tissue. To validate them further, the formulations are compared with the empirical formulation of the CEST effect and other findings of the previous researches. By extending our formulations, the optimal power and the corresponding optimal duration (in the biological systems with many chemical exchange sites) can be determined.

  2. 486nm blue laser operating at 500 kHz pulse repetition frequency

    NASA Astrophysics Data System (ADS)

    Creeden, Daniel; Blanchard, Jon; Pretorius, Herman; Limongelli, Julia; Setzler, Scott D.

    2016-03-01

    Compact, high power blue light in the 470-490nm region is difficult to generate due to the lack of laser sources which are easily convertible (through parametric processes) to those wavelengths. By using a pulsed Tm-doped fiber laser as a pump source for a 2-stage second harmonic generation (SHG) scheme, we have generated ~2W of 486.5nm light at 500kHz pulse repetition frequency (PRF). To our knowledge, this is the highest PRF and output power achieved in the blue region based on a frequency converted, monolithic fiber laser. This pump laser is a pulsed Tm-doped fiber laser/amplifier which generates 12.8W of 1946nm power at 500kHz PRF with diffraction-limited output from a purely single-mode fiber. The output from this laser is converted to 973nm through second harmonic generation (SHG). The 973nm is then converted to 486.5nm via another SHG stage. This architecture operates with very low peak power, which can be challenging from a nonlinear conversion standpoint. However, the low peak power enables the use of a single-mode monolithic fiber amplifier without undergoing nonlinear effects in the fiber. This also eliminates the need for novel fiber designs, large-mode area fiber, or free-space coupling to rod-type amplifiers, improving reliability and robustness of the laser source. Higher power and conversion efficiency are possible through the addition of Tm-doped fiber amplification stages as well as optimization of the nonlinear conversion process and nonlinear materials. In this paper, we discuss the laser layout, results, and challenges with generating blue light using a low peak power approach.

  3. High voltage electrical stimulation in the augmentation of muscle strength: effects of pulse frequency.

    PubMed

    Balogun, J A; Onilari, O O; Akeju, O A; Marzouk, D K

    1993-09-01

    This study was designed to determine the effects of pulse frequency (20pps, 45pps, 80pps) on subjects' voltage tolerance, delayed muscle soreness, and muscle strength gained following 6 weeks of electrical stimulation. Thirty healthy men (mean age = 22 years) were randomly assigned to three groups. Subjects in group 1 (n = 10), group 2 (n = 10), and group 3 (n = 10) had their right quadriceps femoris muscles electrically stimulated with a high-voltage pulsed galvanic stimulator present at pulse frequencies of 20pps, 45pps, and 80pps, respectively. The left limb of each subject served as the control. For all the groups, the duty cycle of the stimulator was set at 10 seconds on and 50 seconds off during the stimulation. At each training session, the maximal tolerable voltage for each subject was monitored. Ten maximum contractions was allowed at each training session. Muscle soreness perception was evaluated 48 hours after stimulation using a 10-point visual analog scale. Electrical stimulation was administered three times a week for 6 weeks. For each subject, the average voltage output and muscle soreness rating were computed at the end of each week. With a cable tensiometer, the knee extension isometric force of both limbs was evaluated before training and at the end of the second, fourth, and sixth weeks of the study and 3 weeks after training. Repeated measure's analysis of variance was used to determine significant differences in the dependent variables. The results showed that the maximum voltage tolerance, muscle soreness ratings, and muscle strength gained by the three groups are not significantly (p > .05) different.(ABSTRACT TRUNCATED AT 250 WORDS)

  4. No Evidence That RFamide-Related Peptide 3 Directly Modulates LH Secretion in the Ewe.

    PubMed

    Decourt, C; Anger, K; Robert, V; Lomet, D; Bartzen-Sprauer, J; Caraty, A; Dufourny, L; Anderson, G; Beltramo, M

    2016-04-01

    The neuropeptide RFamide-related peptide 3 (RFRP-3) has been implicated in the control of gonadotropin secretion in both birds and mammals. However, in mammals, depending on species, sex and photoperiod, inhibitory, excitatory, or no effect of RFRP-3 on the plasma concentration of LH has been reported. In the ewe, treatment with RFRP-3 either reduced LH concentration or had no effect, and treatment with an RFRP-3 receptor antagonist (ie, RF9) resulted in increased concentration of plasma LH. To clarify these conflicting results in the present study, a set of experiments was performed in ewes. Multiple iv injections of RFRP-3 (6 × 50 μg) in ovariectomized ewes had no effect on plasma LH pulsatility. In intact ewes a bolus injection (500 μg) or an injection (250, 500, or 1000 μg) followed by a 4-hour perfusion (250, 500, or 1000 μg · h(-1)) of RFRP-3 had no effect on the LH pulse induced by kisspeptin (6.5 μg). In ovariectomized, estrogen-replaced ewes, the LH surge induced by estradiol benzoate was not modified by a 24-hour perfusion of RFRP-3 (500 μg h(-1)). Finally, although treatment with RF9 induced a robust release of LH, treatment with a more selective RFRP-3 receptor antagonist, GJ14, resulted in no evident increase of LH. In contrast to the inhibitory effect previously suggested, our data are more consistent with the concept that RFRP-3 has no direct effect on LH secretion in ewes and that RF9 effect on LH release is likely not RFRP-3 receptor mediated. Hence, RFRP-3 probably has a minor role on the control of LH secretion in the ewe.

  5. Two pulse-coupled non-identical, frequency-different BZ oscillators with time delay.

    PubMed

    Lavrova, Anastasia I; Vanag, Vladimir K

    2014-04-14

    Two non-identical, frequency-different pulse-coupled oscillators with time delay have been systematically studied using four-variable model of the Belousov-Zhabotinsky (BZ) reaction at mutual inhibitory, mutual excitatory, and mixed excitatory-inhibitory types of coupling. Different resonances like 1 : 2, 2 : 3, 1 : 3, etc., as well as complex rhythms and abrupt changes between them occur depending on the coupling strengths, time delay, and frequency ratio. Analogously to in-phase and anti-phase oscillations for 1 : 1 resonance, a similar phase locking exists for 1 : 2 resonance in the case of inhibitory coupling. For excitatory coupling, a bursting regime is found. The number of spikes in a single burst can be tuned by both the frequency ratio and time delay. For excitatory-inhibitory coupling, a region where one oscillator is suppressed (OS zone) has been found. Boundary of the OS zone depends on the frequency ratio. For weakly coupled oscillators, Farey sequence has been found for excitatory-inhibitory and mutual excitatory coupling.

  6. Optimization of Pulsed-DEER Measurements for Gd-Based Labels: Choice of Operational Frequencies, Pulse Durations and Positions, and Temperature

    SciTech Connect

    Raitsimring, A.; Astashkin, A. V.; Enemark, J. H.; Kaminker, I.; Goldfarb, D.; Walter, E. D.; Song, Y.; Meade, T. J.

    2012-12-29

    In this work, the experimental conditions and parameters necessary to optimize the long-distance (≥ 60 Å) Double Electron-Electron Resonance (DEER) measurements of biomacromolecules labeled with Gd(III) tags are analyzed. The specific parameters discussed are the temperature, microwave band, the separation between the pumping and observation frequencies, pulse train repetition rate, pulse durations and pulse positioning in the electron paramagnetic resonance spectrum. It was found that: (i) in optimized DEER measurements, the observation pulses have to be applied at the maximum of the EPR spectrum; (ii) the optimal temperature range for Ka-band measurements is 14-17 K, while in W-band the optimal temperatures are between 6-9 K; (iii) W-band is preferable to Ka-band for DEER measurements. Recent achievements and the conditions necessary for short-distance measurements (<15 Å) are also briefly discussed.

  7. Full 3D modelling of pulse propagation enables efficient nonlinear frequency conversion with low energy laser pulses in a single-element tripler

    PubMed Central

    Kardaś, Tomasz M.; Nejbauer, Michał; Wnuk, Paweł; Resan, Bojan; Radzewicz, Czesław; Wasylczyk, Piotr

    2017-01-01

    Although new optical materials continue to open up access to more and more wavelength bands where femtosecond laser pulses can be generated, light frequency conversion techniques are still indispensable in filling the gaps on the ultrafast spectral scale. With high repetition rate, low pulse energy laser sources (oscillators) tight focusing is necessary for a robust wave mixing and the efficiency of broadband nonlinear conversion is limited by diffraction as well as spatial and temporal walk-off. Here we demonstrate a miniature third harmonic generator (tripler) with conversion efficiency exceeding 30%, producing 246 fs UV pulses via cascaded second order processes within a single laser beam focus. Designing this highly efficient and ultra compact frequency converter was made possible by full 3-dimentional modelling of propagation of tightly focused, broadband light fields in nonlinear and birefringent media. PMID:28225007

  8. Full 3D modelling of pulse propagation enables efficient nonlinear frequency conversion with low energy laser pulses in a single-element tripler.

    PubMed

    Kardaś, Tomasz M; Nejbauer, Michał; Wnuk, Paweł; Resan, Bojan; Radzewicz, Czesław; Wasylczyk, Piotr

    2017-02-22

    Although new optical materials continue to open up access to more and more wavelength bands where femtosecond laser pulses can be generated, light frequency conversion techniques are still indispensable in filling the gaps on the ultrafast spectral scale. With high repetition rate, low pulse energy laser sources (oscillators) tight focusing is necessary for a robust wave mixing and the efficiency of broadband nonlinear conversion is limited by diffraction as well as spatial and temporal walk-off. Here we demonstrate a miniature third harmonic generator (tripler) with conversion efficiency exceeding 30%, producing 246 fs UV pulses via cascaded second order processes within a single laser beam focus. Designing this highly efficient and ultra compact frequency converter was made possible by full 3-dimentional modelling of propagation of tightly focused, broadband light fields in nonlinear and birefringent media.

  9. Full 3D modelling of pulse propagation enables efficient nonlinear frequency conversion with low energy laser pulses in a single-element tripler

    NASA Astrophysics Data System (ADS)

    Kardaś, Tomasz M.; Nejbauer, Michał; Wnuk, Paweł; Resan, Bojan; Radzewicz, Czesław; Wasylczyk, Piotr

    2017-02-01

    Although new optical materials continue to open up access to more and more wavelength bands where femtosecond laser pulses can be generated, light frequency conversion techniques are still indispensable in filling the gaps on the ultrafast spectral scale. With high repetition rate, low pulse energy laser sources (oscillators) tight focusing is necessary for a robust wave mixing and the efficiency of broadband nonlinear conversion is limited by diffraction as well as spatial and temporal walk-off. Here we demonstrate a miniature third harmonic generator (tripler) with conversion efficiency exceeding 30%, producing 246 fs UV pulses via cascaded second order processes within a single laser beam focus. Designing this highly efficient and ultra compact frequency converter was made possible by full 3-dimentional modelling of propagation of tightly focused, broadband light fields in nonlinear and birefringent media.

  10. Generation of third harmonic picosecond pulses at 355 nm by sum frequency mixing in periodically poled MgSLT crystal

    NASA Astrophysics Data System (ADS)

    Kaltenbach, André; Schönau, Thomas; Lauritsen, Kristian; Tränkle, Günther; Erdmann, Rainer

    2015-02-01

    Third harmonic 355nm picosecond pulses are generated by sum frequency mixing in a periodically poled magnesium doped stoichiometric lithium tantalate (PPMgSLT) crystal. The third harmonic generation is based on the 1064nm radiation of a gain-switched distributed feedback (DFB) diode laser which is amplified by a two-stage fiber amplifier. The diode laser is freely triggerable at variable repetition rates up to 80MHz and provides optical pulses of 65 ps FWHM duration and pulse energies in the range of 5 pJ. The 355nm third harmonic generation is realized in a two-step conversion process. First, the 1064nm fundamental radiation is frequency-doubled to 532 nm, afterwards both frequencies are mixed in the PPMgSLT crystal to 355 nm. The UV-radiation shows a pulse width of 60 ps, a good beam profile and stable pulse energy over a wide range of repetition rates by proprietary pump power management. At 355nm a pulse peak power of 5.3W was achieved with 192W pulse peak power of the fundamental radiation.

  11. Theoretical and Experimental Study of Pulsed Optically Pumped Rubidium Frequency Standard

    NASA Astrophysics Data System (ADS)

    Du, Z. J.

    2013-09-01

    Atomic clocks have been recognized as the critical equipments for the global navigation satellite systems, and their performances determine the positioning accuracies and lifetimes of the satellite navigation systems. In order to ensure the reliability and technological diversity, it is of great importance to study new type atomic clocks with high precision. The advantages such as simple operation, compactness, and small size, make the Rb frequency standard preferred for satellite navigation systems. In order to reduce the light shift and cavity pulling shift, the Pulsed Optically Pumped (POP) Rb frequency standard has been theoretically and experimentally studied in this thesis, in which the pumping, interrogation, and detection phases are separated in time to avoid coupling between the microwave and optical field coherences. A laboratory POP ^{87}Rb frequency standard prototype has been realized. Meanwhile, the Autler-Townes splitting in electromagnetic induced transparency (EIT), which is induced by microwave, has been studied theoretically and experimentally. The main works and results are as follows: (1) In the formalism of the ensemble-averaged density matrix and in the rotating-wave approximation, a set of equations describing the POP clock dynamics with a three-level model has been obtained, and the optimum physical parameters are derived. When atoms are submitted to π/2 Ramsey pulses, it is indicated that: (a) With microwave detection, the full width at half maximum (FWHM) is 1/(4T) (T represents the Ramsey time), and the quality factor of the atomic line is increased by a factor of 2 with respect to the traditional approaches. (b) The light shift effect may be canceled, and cavity pulling effect may be strongly reduced. A better medium-, and long-term frequency stability is obtained. (2) The required characteristics of optics and physics packages have been analyzed. The instruments such as the laser system, microwave cavity, Rb vapor cell, quantization

  12. Zero Voltage Soft Switching Duty Cycle Pulse Modulated High Frequency Inverter-Fed

    NASA Astrophysics Data System (ADS)

    Ishitobi, Manabu; Matsushige, Takayuki; Nakaoka, Mutsuo; Bessyo, Daisuke; Omori, Hideki; Terai, Haruo

    The utility grid voltage of commercial AC power source in Japan and USA is 100V, but in other Asian and European countries, it is 220V. In recent years, in Japan 200V outputted single-phase three-wire system begins to be used for high power applications. In 100V utility AC power applications and systems, an active voltage clamped quasi-resonant inverter circuit topology sing IGBTs has been effectively used so far for the consumer microwave oven. In this paper, presented is a half bridge type voltage-clamped asymmetrical soft switching PWM high-frequency inverter type AC-DC converter using IGBTs which is designed for consumer magnetron drive used as the consumer microwave oven in 200V utility AC power system. The zero voltage soft switching inverter treated here can use the same power rated switching semiconductor devices and three-winding high frequency transformer as those of the active voltage clamped quasi-resonant inverter using the IGBTs that has already been used for 100V utility AC power source. The operating performances of the voltage source single ended push pull (SEPP) type soft switching PWM inverter are evaluated and discussed for 100V and 200V common use consumer microwave oven. The harmonic line current components in the utility AC power side of the AC-DC power converter with ZVS-PWM SEPP inverter are reduced and improved on the basis of sine wave like pulse frequency modulation and sine wave like pulse width modulation for the utility AC voltage source.

  13. Chronic administration of recombinant ovine leptin in growing beef heifers: effects on secretion of LH, metabolic hormones, and timing of puberty.

    PubMed

    Maciel, M N; Zieba, D A; Amstalden, M; Keisler, D H; Neves, J P; Williams, G L

    2004-10-01

    Serum concentrations of leptin increase linearly from approximately 16 wk before until the week of pubertal ovulation in beef heifers. To test the hypothesis that exogenous leptin can hasten the onset of puberty in heifers, we examined the effects of chronic administration of recombinant ovine leptin (oleptin) on timing of puberty, pulsatile and GnRH-mediated release of LH, and plasma concentrations of GH, IGF-I, and insulin. Fourteen fall-born, prepubertal heifers (Brahman x Hereford, 12 to 13 mo; 304.7+/-4.12 kg) were used. Heifers were stratified by age and BW and assigned randomly to one of two groups (seven animals per group): 1) Control; heifers received s.c. injections of saline twice daily (0700 and 1900) for 40 d; and 2) Leptin; heifers received s.c. injections of oleptin (19.2 microg/kg) twice daily at 0700 and 1900 for 40 d. Blood samples were collected at 10-min intervals for 5 h on. d 0, 5, 10, 20, 30, and 40, and twice daily, just before each treatment injection, throughout the study. On d 41, heifers received i.v. injections of GnRH at 0 (0.0011 microg/kg) and 90 min (0.22 microg/kg), with additional sampling for 5.5 h to examine releasable pools of LH. Diets promoted a gain of 0.32+/-0.09 kg/d, which did not differ between groups. Plasma concentrations of leptin increased markedly in leptin-treated heifers and were greater (P < 0.001) than controls throughout (27.8+/-0.8 vs. 4.9+/-0.12 ng/mL). None of the heifers reached puberty during the experiment, but did so within 45 d of its termination. Mean concentrations of plasma LH, GH, IGF-I, and insulin were not affected by treatment, nor was there an overall effect on the frequency of LH pulses. However, a treatment x day interaction (P = 0.02) revealed that the frequency of LH pulses (pulses/ 5 h) was greater (P = 0.03) in controls (3.6+/-0.36) than in leptin-treated heifers (1.7+/- 0.28) on d 10. Characteristics of GnRH-induced release of LH were not affected by treatment. In summary, chronically

  14. Measurement of the frequency response of a diaphragm-based pressure sensor by use of a pulsed excimer laser.

    PubMed

    Shen, Fabin; Xu, Juncheng; Wang, Anbo

    2005-08-01

    We present a novel method for measuring the frequency response of a diaphragm-based optical fiber Fabry-Perot interferometric pressure sensor. The impulse response of the sensor to the radiation pressure generated by an excimer laser pulse is measured. The Fourier transform of the impulse response yields the frequency response of the pressure sensor. Experimental results show that it is a convenient and efficient method for measurement of the frequency response of diaphragm-based pressure sensors.

  15. Multi-frequency accelerating strategy for the contrast source inversion method of ultrasound waveform tomography using pulse data

    NASA Astrophysics Data System (ADS)

    Lin, Hongxiang; Azuma, Takashi; Qu, Xiaolei; Takagi, Shu

    2017-03-01

    In this work, we construct a multi-frequency accelerating strategy for the contrast source inversion (CSI) method using pulse data in the time domain. CSI is a frequency-domain inversion method for ultrasound waveform tomography that does not require the forward solver through the process of reconstruction. Several prior researches show that the CSI method has a good performance of convergence and accuracy in the low-center-frequency situation. In contrast, utilizing the high-center-frequency data leads to a high-resolution reconstruction but slow convergence on large numbers of grid. Our objective is to take full advantage of all low frequency components from pulse data with the high-center-frequency data measured by the diagnostic device. First we process the raw data in the frequency domain. Then multi-frequency accelerating strategy helps restart CSI in the current frequency using the last iteration result obtained from the lower frequency component. The merit of multi- frequency accelerating strategy is that computational burden decreases at the first few iterations. Because the low frequency component of dataset computes on the coarse grid with assuming a fixed number of points per wavelength. In the numerical test, the pulse data were generated by the K-wave simulator and have been processed to meet the computation of the CSI method. We investigate the performance of the multi-frequency and single-frequency reconstructions and conclude that the multi-frequency accelerating strategy significantly enhances the quality of the reconstructed image and simultaneously reduces the average computational time for any iteration step.

  16. Pulse-fitting - A novel method for the evaluation of pulse measurements, demonstrated for the low frequency behavior of lithium-ion cells

    NASA Astrophysics Data System (ADS)

    Schmidt, Jan Philipp; Ivers-Tiffée, Ellen

    2016-05-01

    The impedance of a commercial lithium ion cell (2 Ah) is evaluated over a wide frequency range of 10-5 Hz < f < 102 Hz using a new approach. The so-called pulse-fitting method (PFM) derives the cell impedance from time domain measurements, which are transferred into frequency data by a using a newly developed evaluation algorithm in combination with the distribution of relaxation times (DRT). The time constants of the individual polarization processes taking place during charging/discharging were analyzed at 20 different state-of-charge levels at 23 °C in a wide frequency range spanning from 10-5 Hz < f < 102 Hz. The pulse-fitting method seems to be especially useful for monitoring the change of individual polarization losses in the course of time, as self-discharge effects can be sorted out.

  17. An Investigation on the Effect of Extremely Low Frequency Pulsed Electromagnetic Fields on Human Electrocardiograms (ECGs)

    PubMed Central

    Fang, Qiang; Mahmoud, Seedahmed S.; Yan, Jiayong; Li, Hui

    2016-01-01

    For this investigation, we studied the effects of extremely low frequency pulse electromagnetic fields (ELF-PEMF) on the human cardiac signal. Electrocardiograms (ECGs) of 22 healthy volunteers before and after a short duration of ELF-PEMF exposure were recorded. The experiment was conducted under single-blind conditions. The root mean square (RMS) value of the recorded data was considered as comparison criteria. We also measured and analysed four important ECG time intervals before and after ELF-PEMF exposure. Results revealed that the RMS value of the ECG recordings from 18 participants (81.8% of the total participants) increased with a mean value of 3.72%. The increase in ECG voltage levels was then verified by a second experimental protocol with a control exposure. In addition to this, we used hyperbolic T-distributions (HTD) in the analysis of ECG signals to verify the change in the RR interval. It was found that there were small shifts in the frequency-domain signal before and after EMF exposure. This shift has an influence on all frequency components of the ECG signals, as all spectrums were shifted. It is shown from this investigation that a short time exposure to ELF-PEMF can affect the properties of ECG signals. Further study is needed to consolidate this finding and discover more on the biological effects of ELF-PEMF on human physiological processes. PMID:27886102

  18. A numerical study of the effect of frequency of pulsed flow control applied to a rectangular cavity in supersonic crossflow

    NASA Astrophysics Data System (ADS)

    Stanek, Michael J.

    Stabilization of turbulent free shear flows is a poorly understood, and recently discovered flow phenomenon, not described in modern textbooks on fluid dynamics. This dissertation describes the design and large-scale experimental test of one type of flow control actuator, a rod in crossflow, which is shown to pulse at high frequency (relative to the dominant instabilities of a turbulent free shear layer), and in the process, locally stabilizes that shear layer. The shear layer in question spans a cavity (representative of a 1/10th scale modern aircraft weapons bay) in supersonic (Mach 1.2) crossflow. Without the high frequency flow control, the cavity experiences acoustic resonance (and the creation of large coherent vortical structures), which creates sound pressure levels high enough to fatigue aircraft components. With the high frequency control (and the local shear layer stabilization), the sound pressure levels are rendered benign. Evidence of suppression due to other types of high frequency pulsing devices (primarily resonance tube type designs) is also presented. A numerical study is undertaken to investigate the nature of the stabilization and acoustic suppression. An implicit, 2nd-order in space and time flow solver, coupled with a recently-developed hybrid RANS-LES turbulence model by Nichols, is utilized in a Chimera-based parallel format, to numerically simulate both the unsuppressed cavity in resonance, as well as the effect of pulsing flow control. Due to the limited ability to vary frequency using a rod in crossflow type device, a pulsed jet device is simulated instead. Frequency (and in a limited number of cases, amplitude) of pulse is varied, from 0 Hz (steady) up to 5000 Hz. The change in the character of the flow control effect as pulsing frequency is changed is described, and linked to changes in acoustic levels. The observed local stabilization of the cavity turbulent shear layer is shown in simulation to be the result of a violent instability

  19. Tailored sinc pulses for uniform excitation and artifact-free radio frequency time-domain EPR imaging.

    PubMed

    Devasahayam, N; Murugesan, R; Matsumoto, K; Mitchell, J B; Cook, J A; Subramanian, S; Krishna, M C

    2004-05-01

    A method to generate shaped radiofrequency pulses for uniform excitation of electron spins in time-domain radio frequency (RF) electron paramagnetic resonance (EPR) imaging is presented. A commercial waveform generator was integrated with the transmit arm of the existing time-domain RF-EPR spectrometer to generate tailored excitation pulses with sub-nano second resolution for excitation with a 90 degrees flip-angle. A truncated sinc [sin(x)/x] pulse, tailored to compensate for the Q-profile (RF frequency response) of the resonator, was shown to yield images from phantom objects as well as in vivo images, with minimal distortion. These studies point to the advantages in using shaped sinc pulses to achieve improved uniform excitation over a relatively wide bandwidth region in time-domain RF-EPR imaging (RF-FT-EPRI).

  20. Pulse

    MedlinePlus

    ... the underside of the opposite wrist, below the base of the thumb. Press with flat fingers until ... determine if the patient's heart is pumping. Pulse measurement has other uses as well. During or immediately ...

  1. Group velocity mismatch-absent nonlinear frequency conversions for mid-infrared femtosecond pulses generation

    PubMed Central

    Zhong, Haizhe; Zhang, Lifu; Li, Ying; Fan, Dianyuan

    2015-01-01

    A novel group velocity mismatch (GVM) absent scheme for nonlinear optical parametric procedure in mid-infrared was developed with type-I quasi phase matching by use of an off-digital nonlinear optical coefficient d31. This was achieved by matching of the group velocities of the pump and the signal waves, while the phase velocities were quasi phase matched. The system employs MgO-doped periodically poled LiNbO3 as the nonlinear medium. Desired group-velocity dispersion would be obtained via appropriately temperature regulation. To demonstrate its potential applications in ultrafast mid-infrared pulses generation, aiming at a typical mid-infrared wavelength of ~3.2 μm, design examples of two basic nonlinear frequency conversion procedures are studied for both the narrow-band seeding mid-IR optical parametric amplification (OPA) and the synchronously pumped femtosecond optical parametric oscillation (SPOPO). Compared with the conventional scheme of type-0 QPM, the quantum-efficiency can be more than doubled with nearly unlimited bandwidth. The proposed GVM- absent phase matching design may provide a promising route to efficient and broadband sub-100 fs mid-infrared ultrafast pulses generation without group-velocity walk-off. PMID:26099837

  2. Gas breakdown mechanism in pulse-modulated asymmetric ratio frequency dielectric barrier discharges

    NASA Astrophysics Data System (ADS)

    Wang, Qi; Sun, Jizhong; Nozaki, Tomohiro; Ding, Zhenfeng; Ding, Hongbin; Wang, Zhanhui; Wang, Dezhen

    2014-08-01

    The gas breakdown mechanisms, especially the roles of metastable species in atmospheric pressure pulse-modulated ratio frequency barrier discharges with co-axial cylindrical electrodes, were studied numerically using a one dimensional self-consistent fluid model. Simulation results showed that in low duty cycle cases, the electrons generated from the channels associated with metastable species played a more important role in initializing next breakdown than the direct ionization of helium atoms of electronic grounded states by electron-impact. In order to quantitatively evaluate the contribution to the discharge by the metastables, we defined a "characteristic time" and examined how the value varied with the gap distance and the electrode asymmetry. The results indicated that the lifetime of the metastable species (including He*and He2*) was much longer than that of the pulse-on period and as effective sources of producing electrons they lasted over a period up to millisecond. When the ratio of the outer radius to the inner radius of the cylindrical electrodes was far bigger than one, it was found that the metastables distributed mainly in a cylindrical region around the inner electrode. When the ratio decreased as the inner electrode moved outward, the density of metastables in the discharge region near the outer electrode became gradually noticeable. As the discharging gap continued to decrease, the two hill-shaped distributions gradually merged to one big hill. When the discharge spacing was fixed, asymmetric electrodes facilitated the discharge.

  3. Phase-locking and Pulse Generation in Multi-Frequency Brillouin Oscillator via Four Wave Mixing

    NASA Astrophysics Data System (ADS)

    Büttner, Thomas F. S.; Kabakova, Irina V.; Hudson, Darren D.; Pant, Ravi; Poulton, Christopher G.; Judge, Alexander C.; Eggleton, Benjamin J.

    2014-05-01

    There is an increasing demand for pulsed all-fibre lasers with gigahertz repetition rates for applications in telecommunications and metrology. The repetition rate of conventional passively mode-locked fibre lasers is fundamentally linked to the laser cavity length and is therefore typically ~10-100 MHz, which is orders of magnitude lower than required. Cascading stimulated Brillouin scattering (SBS) in nonlinear resonators, however, enables the formation of Brillouin frequency combs (BFCs) with GHz line spacing, which is determined by the acoustic properties of the medium and is independent of the resonator length. Phase-locking of such combs therefore holds a promise to achieve gigahertz repetition rate lasers. The interplay of SBS and Kerr-nonlinear four-wave mixing (FWM) in nonlinear resonators has been previously investigated, yet the phase relationship of the waves has not been considered. Here, we present for the first time experimental and numerical results that demonstrate phase-locking of BFCs generated in a nonlinear waveguide cavity. Using real-time measurements we demonstrate stable 40 ps pulse trains with 8 GHz repetition rate based on a chalcogenide fibre cavity, without the aid of any additional phase-locking element. Detailed numerical modelling, which is in agreement with the experimental results, highlight the essential role of FWM in phase-locking of the BFC.

  4. Migrating temperature "thermo-chromatographic" pulses (TCP) initiated by radio-frequency (RF) heating.

    PubMed

    Kraus, Markus; Kopinke, Frank-Dieter; Roland, Ulf

    2012-01-01

    In the present study, the astonishing influence of water dosage on a purged dry packed bed of NaY zeolite in the presence of an electric field with a frequency of 13.56 MHz was investigated. The injection of a small amount of water to the inlet of the bed led to pronounced selective heating of the inlet zone by more than 150 K. Thus, water represented a very effective coupling medium for dielectric heating. The selectively heated zone then slowly moved through the whole packed bed and a water pulse finally left the zeolite. This effect correlated with a coupled water and heat flux was called thermo-chromatographic pulse (TCP) emphasizing its analogy to chromatography. The phenomenon could not be performed by using conventional (convective) or microwave heating. It was demonstrated under various conditions and explained by a new model based on own experimental results as well as data from literature. The model will be the objective of a forthcoming publication.

  5. On the passage of high-level pulsed radio frequency interference through a nonlinear satellite transponder

    NASA Technical Reports Server (NTRS)

    Weinberg, A.

    1984-01-01

    Attention is given to the uncoded bit error rate (BER) performance of a satellite communications system whose modulation scheme is binary PSK and whose transponder contains an arbitrary amplitude nonlinearity, all in the presence of high level pulsed radio frequency interference (RFI). A general approach is presented for direct BER evaluations, in contrast to other approaches which may employ SNR suppression factors. The computed results are based on arbitrarily specified RFI scenarios, in the presence of hard limiter, clipper, or blanker amplitude nonlinearities. Performance curves demonstrate the superiority of an appropriately chosen blanker when the RFI environment is most severe. The results obtained also pertain to the sensitivity of performance to the information bit rate, signal power variations, and the ratio of CW to noise content. The CW effects are found to be the most severe.

  6. Terahertz emission driven by two-color laser pulses at various frequency ratios

    NASA Astrophysics Data System (ADS)

    Wang, W.-M.; Sheng, Z.-M.; Li, Y.-T.; Zhang, Y.; Zhang, J.

    2017-08-01

    We present a simulation study of terahertz radiation from a gas driven by two-color laser pulses in a broad range of frequency ratios ω1/ω0 . Our particle-in-cell simulation results show that there are three series with ω1/ω0=2 n , n +1 /2 , n ±1 /3 (n is a positive integer) for high-efficiency and stable radiation generation. The radiation strength basically decreases with the increasing ω1 and scales linearly with the laser wavelength. These rules are broken when ω1/ω0<1 and much stronger radiation may be generated at any ω1/ω0 . These results can be explained with a model based on gas ionization by two linear-superposition laser fields, rather than a multiwave mixing model.

  7. Dynamical regimes of two frequency different chemical oscillators coupled via pulse inhibitory coupling with time delay

    NASA Astrophysics Data System (ADS)

    Proskurkin, I. S.; Vanag, V. K.

    2015-02-01

    Resonance regimes of two frequency different chemical oscillators coupled via pulsed inhibitory coupling with time delay τ have been studied theoretically and experimentally. The Belousov-Zhabotinsky reaction is used as a chemical oscillator. Regions of the 1: 1, 2: 3, 1: 2, 2: 5, and 1: 3 resonances, as well as complex oscillations and a regime in which one oscillator is suppressed have been found in the parameter plane "the ratio between the T 2/ T 1-τ." For the 1: 2 resonance, a sharp transition from one synchronized regime (called "0/0.5") to the other one (called "0.2/0.7") has been found. This transition (reminiscent to the transition between in-phase and anti-phase oscillations in case of the 1: 1 resonance) is controlled by time delay τ and the coupling strength.

  8. Effect of Finite Pulse Length and Laser Frequency Chirp on HGHG and EEHG Seeding

    SciTech Connect

    Stupakov, G.; /SLAC

    2011-11-18

    Theoretical studies of high-gain harmonic generation (HGHG) and echo-enabled harmonic generation (EEHG) often start from a simplified model in which the beam is assumed infinitely long and longitudinally uniform and the laser induced energy modulation is perfectly sinusoidal and of infinite duration. In such a model the resulting seed has a spectrum consisting of a collection of delta-functions (of zero width) located at the harmonics of the laser frequency. Being a useful tool for study of the seed bunching amplitudes, such a model cannot be used for realistic analysis the spectral properties of the seed. In this paper we take into account the finite duration of the laser pulse as well as some possible laser phase errors to study their effect on the spectrum of the seed.

  9. Extremely low frequency pulsed electromagnetic fields increase cell proliferation in lymphocytes from young and aged subjects

    SciTech Connect

    Cossarizza, A.; Monti, D.; Bersani, F.; Cantini, M.; Cadossi, R.; Sacchi, A.; Franceschi, C.

    1989-04-28

    The effect of the in vitro exposure to extremely low frequency pulsed electromagnetic fields (PEMFs) on the proliferation of human lymphocytes from 24 young and 24 old subjects was studied. The exposure to PEMFs during a 3-days culture period or during the first 24 hours was able to increase phytohaemagglutinin-induced lymphocyte proliferation in both groups. Such effect was greater in lymphocytes from old people which showed a markedly reduced proliferative capability and, after PEMF exposure, reached values of /sup 3/H-TdR incorporation similar to those of young subjects. The relevance of these data for the understanding and the reversibility of the proliferative defects in cells from aged subjects and for the assessment of risk related to the environmental exposure to PEMFs has to be considered.

  10. Reconfiguration of spectral absorption features using a frequency-chirped laser pulse.

    PubMed

    Tian, Mingzhen; Chang, Tiejun; Merkel, Kristian D; Babbitt, W Randall

    2011-12-20

    A technique is proposed to manipulate atomic population in an inhomogeneously broadened medium, which can set an arbitrary absorption spectrum to a uniform transparency (erasure) or to a nearly complete inversion. These reconfigurations of atomic spectral distribution are achieved through excitation of electronic transitions using a laser pulse with chirped frequency, which precisely affects selected spectral regions while leaving the rest of the spectrum unperturbed. An erasure operation sets the final atomic population inversion to zero and the inversion operation flips the population between the ground and the excited states, regardless of the previously existing population distribution. This technique finds important applications both in optical signal processing, where fast, recursive processing and high dynamic range are desirable and in quantum memory and quantum computing, which both require high efficiency and high fidelity in quantum state preparation of atomic ensembles. Proof-of-concept demonstrations were performed in a rare-earth doped crystal.

  11. Fixed lag smoothing target tracking in clutter for a high pulse repetition frequency radar

    NASA Astrophysics Data System (ADS)

    Khan, Uzair; Shi, Yi Fang; Song, Taek Lyul

    2015-12-01

    A new method to smooth the target hybrid state with Gaussian mixture measurement likelihood-integrated track splitting (GMM-ITS) in the presence of clutter for a high pulse repetition frequency (HPRF) radar is proposed. This method smooths the target state at fixed lag N and considers all feasible multi-scan target existence sequences in the temporal window of scans in order to smooth the target hybrid state. The smoothing window can be of any length N. The proposed method to smooth the target hybrid state at fixed lag is also applied to the enhanced multiple model (EMM) tracking algorithm. Simulation results indicate that the performance of fixed lag smoothing GMM-ITS significantly improves false track discrimination and root mean square errors (RMSEs).

  12. Frequency-time coherence for all-optical sampling without optical pulse source

    PubMed Central

    Preußler, Stefan; Raoof Mehrpoor, Gilda; Schneider, Thomas

    2016-01-01

    Sampling is the first step to convert an analogue optical signal into a digital electrical signal. The latter can be further processed and analysed by well-known electrical signal processing methods. Optical pulse sources like mode-locked lasers are commonly incorporated for all-optical sampling, but have several drawbacks. A novel approach for a simple all-optical sampling is to utilise the frequency-time coherence of each signal. The method is based on only using two coupled modulators driven with an electrical sine wave. Since no optical source is required, a simple integration in appropriate platforms, such as Silicon Photonics might be possible. The presented method grants all-optical sampling with electrically tunable bandwidth, repetition rate and time shift. PMID:27687495

  13. Variable frequency pulsed phase-locked loop method for measuring material nonlinearity

    NASA Technical Reports Server (NTRS)

    Yost, William T.; Cantrell, John H.

    1992-01-01

    The design of a pressure vessel with an isothermal volume to measure changes in the natural velocities of material continuously over a wide temperature range is reported. Highly sensitive pulsed phase-locked loop technology is used to measure the natural velocity of fatigued aluminum 2024-T4 as a function of pressure at different temperatures. Second derivative variations with respect to pressure and temperature are found to exhibit order-of-magnitude changes at a gauge pressure near 950 kPa at room temperature. This indicates a significant change in certain combinations of second-order and higher-order elastic constants at relatively low pressures. Fractional frequency change as a function of applied pressure for aluminum 2024-T4 with fatigue damage is illustrated.

  14. A pulse-frequency modulation sensor using memristive-based inhibitory interconnections.

    PubMed

    Kavehei, Omid; Lee, Sang-Jin; Cho, Kyoung-Rok; Al-Sarawi, Said; Abbott, Derek

    2013-05-01

    This paper proposes a programmable inhibitory interconnection network between pixels in an array of novel low-voltage Schmitt-trigger-based PFM sensors that will be of interest for future applications in memristor-based early vision processing. In addition, a new low-power inverter-based pulse-frequency modulation (PFM) design and its integration with the network is also presented. To ensure no change in the memristors conductance in the network, the CMOS imager was designed for low voltage operation. That has resulted in a significant power reduction, better than 60%, and a comparable linear dynamic range when compared to published designs in the literature. The design was performed using a 0.13 um Samsung Electronics standard CMOS process, using 0.75 V supply voltage.

  15. Electron energy enhancement by frequency chirp of a radially polarized laser pulse during ionization of low-density gases

    NASA Astrophysics Data System (ADS)

    Pal Singh, Kunwar; Arya, Rashmi; Malik, Anil K.; Fisch, N. J.

    2016-11-01

    A scheme is proposed to enhance the energy of the electrons generated during the ionization of low-density krypton ions \\text{K}{{\\text{r}}32+} and argon ions \\text{A}{{\\text{r}}16+} by a radially polarized laser pulse using a negative frequency chirp. If a suitable frequency chirp is introduced then the energy of the electrons increases significantly and scattering decreases. The optimum value of the frequency chirp decreases with laser intensity and as well as spot size. The laser spot size also has an optimum value. The electron energy shows strong initial phase dependence. The scheme can be used to obtain quasi-monoenergetic collimated \\text{MeV}/\\text{GeV} electrons using the right choice of parameters. The chirped radially polarized laser pulse is more efficient than a chirped circularly polarized laser pulse to enhance energy and obtain quasi-monoenergetic electron beams.

  16. Mode-Selective Photon Counting Via Quantum Frequency Conversion Using Spectrally-Engineered Pump Pulses

    NASA Astrophysics Data System (ADS)

    Manurkar, Paritosh

    Most of the existing protocols for quantum communication operate in a two-dimensional Hilbert space where their manipulation and measurement have been routinely investigated. Moving to higher-dimensional Hilbert spaces is desirable because of advantages in terms of longer distance communication capabilities, higher channel capacity and better information security. We can exploit the spatio-temporal degrees of freedom for the quantum optical signals to provide the higher-dimensional signals. But this necessitates the need for measurement and manipulation of multidimensional quantum states. To that end, there have been significant theoretical studies based on quantum frequency conversion (QFC) in recent years even though the experimental progress has been limited. QFC is a process that allows preservation of the quantum information while changing the frequency of the input quantum state. It has deservedly garnered a lot of attention because it serves as the connecting bridge between the communications band (C-band near 1550 nm) where the fiber-optic infrastructure is already established and the visible spectrum where high efficiency single-photon detectors and optical memories have been demonstrated. In this experimental work, we demonstrate mode-selective frequency conversion as a means to measure and manipulate photonic signals occupying d -dimensional Hilbert spaces where d=2 and 4. In the d=2 case, we demonstrate mode contrast between two temporal modes (TMs) which serves as the proof-of-concept demonstration. In the d=4 version, we employ six different TMs for our detailed experimental study. These TMs also include superposition modes which are a crucial component in many quantum key distribution protocols. Our method is based on producing pump pulses which allow us to upconvert the TM of interest while ideally preserving the other modes. We use MATLAB simulations to determine the pump pulse shapes which are subsequently produced by controlling the amplitude and

  17. Studies of the lethargic (lh/lh) mouse model of absence seizures: regulatory mechanisms and identification of the lh gene.

    PubMed

    Hosford, D A; Lin, F H; Wang, Y; Caddick, S J; Rees, M; Parkinson, N J; Barclay, J; Cox, R D; Gardiner, R M; Hosford, D A; Denton, P; Wang, Y; Seldin, M F; Chen, B

    1999-01-01

    To understand the cellular and molecular mechanisms that underlie generalized absence seizures sufficiently well to design rational, efficacious new therapies for patients, it is necessary to turn to animal models to gain insights into these mechanisms. The lethargic (lh/lh) mutant mouse expresses spontaneous absence seizures that share behavioral, electrographic, and anticonvulsant profiles with absence seizures in patients. This validates its use to study the mechanisms that underlie absence seizures. This chapter discusses two scientific approaches that involve the use of lh/lh mice. The first part of the chapter discusses neurobiologic approaches used to investigate critical mechanisms that regulate the synchronized burst firing within the thalamocortical network that generates absence seizures. Two of these critical mechanisms have been studied in detail with lh/lh mice. The first critical mechanism involves the required activation of gamma-aminobutyric acid B (GABAB) receptors to generate absence seizures. Because the numbers of GABAB receptors are increased in thalamocortical populations among lh/lh mice compared with littermates without epilepsy, these receptors appear to play a pathophysiologic role in the expression of absence seizures among lh/lh mice. Moreover, there may be a role for GABAB receptors in the generation of absence seizures among humans, because administration of compounds that activate GABAB receptors can produce absence seizures among humans. These findings suggest that GABAB receptor antagonists may represent a new class of antiabsence compounds that will be efficacious against absence seizures among patients. A second critical mechanism that regulates generation of absence seizures involves GABAA receptors in the nucleus reticularis thalami (NRT), a nucleus that sends GABA-ergic afferents to thalamic relay nuclei. Activation of GABAA receptors in the NRT appears to suppress the generation of absence seizures among lh/lh mice and in

  18. Pulsed radio frequency energy in the treatment of painful chronic cutaneous wounds: a report of two cases.

    PubMed

    Maier, Michael

    2011-05-01

    Chronic cutaneous wounds may cause considerable pain, often affecting patient compliance with necessary treatment protocols. Two patients are presented who were unable to comply with compression therapy because of severe wound pain. Adjunctive pulsed radio frequency energy was administered for 30 minutes twice daily through an applicator pad placed directly on the dressing over the wound area. Both patients reported immediate, marked pain reduction, allowing compression therapy. The ulcers healed completely within 3 weeks for patient 1 and 28 weeks for patient 2. Further investigation into the efficacy of pulsed radio frequency energy for the treatment of painful wounds is warranted. Wiley Periodicals, Inc.

  19. The pulse amplitude variation with QPO frequency in SAX J1808.4-3658: Resonances with the accretion disk

    NASA Astrophysics Data System (ADS)

    Caliskan, Sirin; Alpar, Mehmet Ali; Sasmaz Mus, Sinem

    2016-07-01

    SAX J1808.4-3658 is an accreting millisecond pulsar with a spin period of 401 Hz. The pulsed amplitudes of this source vary with its kHz QPO frequencies (Bult & van der Klis 2015). The pulsed amplitude peaks at certain upper kHz QPO frequencies which we associate with boundary layer modes of the viscous accretion disk (Erkut et al. 2008). We model this as peaks in the energy dissipation rate at the accretion caps due to resonances between the accretion column and the driving modes of the boundary layer.

  20. Design and Operation of a 9-bit Single-flux-quantum Pulse-frequency Modulation Digital-to-analog Converter

    NASA Astrophysics Data System (ADS)

    Mizugaki, Yoshinao; Takahashi, Yoshitaka; Shimada, Hiroshi; Maezawa, Masaaki

    We designed and operated a 9-bit single-flux-quantum (SFQ) digital-to-analog converter (DAC). SFQ pulse-frequency modulation (PFM) was employed for generation of variable quantum output voltage, where a 9-bit variable pulse number multiplier and a 100-fold voltage multiplier were the key components. Test chips were fabricated using a Nb Josephson integration technology. Arbitrary voltage waveforms were synthesized with the maximum voltage of 2.54 mV. For ac voltage standard applications, relationships between the DAC resolution and the synthesized waveform frequency are discussed.

  1. Using pulse oximetry to account for high and low frequency physiological artifacts in the BOLD signal.

    PubMed

    Verstynen, Timothy D; Deshpande, Vibhas

    2011-04-15

    The BOLD signal not only reflects changes in local neural activity, but also exhibits variability from physiological processes like cardiac rhythms and breathing. We investigated how both of these physiological sources are reflected in the pulse oximetry (PO) signal, a direct measure of blood oxygenation, and how this information can be used to account for different types of noise in the BOLD response. Measures of heart rate, respiration and PO were simultaneously recorded while neurologically healthy participants performed an eye-movement task in a 3T MRI. PO exhibited power in frequencies that matched those found in the independently recorded cardiac and respiration signals. Using the phasic and aphasic properties of these signals as nuisance regressors, we found that the different frequency components of the PO signal could be used to identify different types of physiological artifacts in the BOLD response. A comparison of different physiological noise models found that a simple, down-sampled version of the PO signal improves the estimation of task-relevant statistics nearly as well as more established noise models that may run the risk of over-parameterization. These findings suggest that the PO signal captures multiple sources of physiological noise in the BOLD response and provides a simple and efficient way of modeling these noise sources in subsequent analysis.

  2. Piezo-Hydraulic Actuation for Driving High Frequency Miniature Split-Stirling Pulse Tube Cryocoolers

    NASA Astrophysics Data System (ADS)

    Garaway, I.; Grossman, G.

    2008-03-01

    In recent years piezoelectric actuation has been identified as a promising means of driving miniature Stirling devices. It supports miniaturization, has a high power to volume ratio, can operate at almost any frequency, good electrical to mechanical efficiencies, and potentially has a very long operating life. The major drawback of piezoelectric actuation, however, is the very small displacements that this physical phenomenon produces. This study shows that by employing valve-less hydraulic amplification an oscillating pressure wave can be created that is sufficiently large to drive a high frequency miniature pulse tube cryocooler (as high as 500 Hz in our experiments and perhaps higher). Beyond the direct benefits derived from using piezoelectric actuation, there are further benefits derived from using the piezo-hydraulic arrangement with membranes. Due to the incompressibility of the hydraulic fluid, the actuator may be separated from the main body of the cryocooler by relatively large distances with almost no detrimental effects, and the complete lack of rubbing parts in the power conversion processes makes this type of cryocooler extremely robust. The design and experimental device, coined the "Piezo-Hydraulic Membrane Oscillator", are presented along with some test results.

  3. Emission characteristics of 6.78-MHz radio-frequency glow discharge plasma in a pulsed mode

    NASA Astrophysics Data System (ADS)

    Zhang, Xinyue; Wagatsuma, Kazuaki

    2017-07-01

    This paper investigated Boltzmann plots for both atomic and ionic emission lines of iron in an argon glow discharge plasma driven by 6.78-MHz radio-frequency (RF) voltage in a pulsed operation, in order to discuss how the excitation/ionization process was affected by the pulsation. For this purpose, a pulse frequency as well as a duty ratio of the pulsed RF voltage was selected as the experimenter parameters. A Grimm-style radiation source was employed at a forward RF power of 70 W and at an argon pressures of 670 Pa. The Boltzmann plot for low-lying excited levels of iron atom was on a linear relationship, which was probably attributed to thermal collisions with ultimate electrons in the negative glow region; in this case, the excitation temperature was obtained in a narrow range of 3300-3400 K, which was hardly affected by the duty ratio as well as the pulse frequency of the pulsed RF glow discharge plasma. This observation suggested that the RF plasma could be supported by a self-stabilized negative glow region, where the kinetic energy distribution of the electrons would be changed to a lesser extent. Additional non-thermal excitation processes, such as a Penning-type collision and a charge-transfer collision, led to deviations (overpopulation) of particular energy levels of iron atom or iron ion from the normal Boltzmann distribution. However, their contributions to the overall excitation/ionization were not altered so greatly, when the pulse frequency or the duty ratio was varied in the pulsed RF glow discharge plasma.

  4. Influence of treatment time and pulse frequency on Salmonella Enteritidis, Escherichia coli and Listeria monocytogenes populations inoculated in melon and watermelon juices treated by pulsed electric fields.

    PubMed

    Mosqueda-Melgar, Jonathan; Raybaudi-Massilia, Rosa M; Martín-Belloso, Olga

    2007-06-30

    Consumption of unpasteurized melon and watermelon juices has caused several disease outbreaks by pathogenic microorganisms worldwide. Pulsed electric field (PEF) has been recognized as a technology that may inactivate those bacteria present in fluid food products at low temperatures. Hence, PEF treatment at 35 kV/cm, 4 mus pulse duration in bipolar mode and square shape were applied on Salmonella Enteritidis, E. coli and L. monocytogenes populations inoculated in melon and watermelon juices without exceeding 40 degrees C outlet temperatures. Different levels of treatment time and pulse frequency were applied to evaluate their effects on these microorganisms. Treatment time was more influential than pulse frequency (P

  5. Low intensity and frequency pulsed electromagnetic fields selectively impair breast cancer cell viability.

    PubMed

    Crocetti, Sara; Beyer, Christian; Schade, Grit; Egli, Marcel; Fröhlich, Jürg; Franco-Obregón, Alfredo

    2013-01-01

    A common drawback of many anticancer therapies is non-specificity in action of killing. We investigated the potential of ultra-low intensity and frequency pulsed electromagnetic fields (PEMFs) to kill breast cancer cells. Our criteria to accept this technology as a potentially valid therapeutic approach were: 1) cytotoxicity to breast cancer cells and; 2) that the designed fields proved innocuous to healthy cell classes that would be exposed to the PEMFs during clinical treatment. MCF7 breast cancer cells and their normal counterparts, MCF10 cells, were exposed to PEMFs and cytotoxic indices measured in order to design PEMF paradigms that best kill breast cancer cells. The PEMF parameters tested were: 1) frequencies ranging from 20 to 50 Hz; 2) intensities ranging from 2 mT to 5 mT and; 3) exposure durations ranging from 30 to 90 minutes per day for up to three days to determine the optimum parameters for selective cancer cell killing. We observed a discrete window of vulnerability of MCF7 cells to PEMFs of 20 Hz frequency, 3 mT magnitude and exposure duration of 60 minutes per day. The cell damage accrued in response to PEMFs increased with time and gained significance after three days of consecutive daily exposure. By contrast, the PEMFs parameters determined to be most cytotoxic to breast cancer MCF-7 cells were not damaging to normal MCF-10 cells. Based on our data it appears that PEMF-based anticancer strategies may represent a new therapeutic approach to treat breast cancer without affecting normal tissues in a manner that is non-invasive and can be potentially combined with existing anti-cancer treatments.

  6. Low Intensity and Frequency Pulsed Electromagnetic Fields Selectively Impair Breast Cancer Cell Viability

    PubMed Central

    Crocetti, Sara; Beyer, Christian; Schade, Grit; Egli, Marcel; Fröhlich, Jürg; Franco-Obregón, Alfredo

    2013-01-01

    Introduction A common drawback of many anticancer therapies is non-specificity in action of killing. We investigated the potential of ultra-low intensity and frequency pulsed electromagnetic fields (PEMFs) to kill breast cancer cells. Our criteria to accept this technology as a potentially valid therapeutic approach were: 1) cytotoxicity to breast cancer cells and; 2) that the designed fields proved innocuous to healthy cell classes that would be exposed to the PEMFs during clinical treatment. Methods MCF7 breast cancer cells and their normal counterparts, MCF10 cells, were exposed to PEMFs and cytotoxic indices measured in order to design PEMF paradigms that best kill breast cancer cells. The PEMF parameters tested were: 1) frequencies ranging from 20 to 50 Hz; 2) intensities ranging from 2 mT to 5 mT and; 3) exposure durations ranging from 30 to 90 minutes per day for up to three days to determine the optimum parameters for selective cancer cell killing. Results We observed a discrete window of vulnerability of MCF7 cells to PEMFs of 20 Hz frequency, 3 mT magnitude and exposure duration of 60 minutes per day. The cell damage accrued in response to PEMFs increased with time and gained significance after three days of consecutive daily exposure. By contrast, the PEMFs parameters determined to be most cytotoxic to breast cancer MCF-7 cells were not damaging to normal MCF-10 cells. Conclusion Based on our data it appears that PEMF-based anticancer strategies may represent a new therapeutic approach to treat breast cancer without affecting normal tissues in a manner that is non-invasive and can be potentially combined with existing anti-cancer treatments. PMID:24039828

  7. Efficacy of Pulsed 405-nm Light-Emitting Diodes for Antimicrobial Photodynamic Inactivation: Effects of Intensity, Frequency, and Duty Cycle

    PubMed Central

    Gillespie, Jonathan B.; Given, Martin J.; Wilson, Mark P.; Judd, Martin D.; Timoshkin, Igor V.; MacGregor, Scott J.

    2017-01-01

    Abstract Objective: This study investigates possible advantages in pulsed over continuous 405-nm light-emitting diode (LED) light for bacterial inactivation and energy efficiency. Background: Alternative nonantibiotic methods of disinfection and infection control have become of significant interest. Recent studies have demonstrated the application of systems using 405-nm LEDs for continuous disinfection of the clinical environment, and also for potential treatment of contaminated wounds. Methods: Liquid suspensions of 103 colony-forming units/mL populations of Staphylococcus aureus were subject to pulsed 405-nm light of different frequencies, duty cycles, and intensities and for different lengths of time. Results: Pulsed exposures with the same average irradiance of 16 mW/cm2 and varying duty cycle (25%, 50%, 75%) showed very similar performance compared with continuous exposures, with 95–98% reduction of S. aureus achieved for all duty cycles. The pulsing frequency was varied in intervals from 100 Hz to 10 kHz and appeared to have little effect on antimicrobial efficacy. However, when comparing pulsed with continuous exposure, an improvement in inactivation per unit optical energy was achieved, with results showing an increase of approximately 83% in optical efficiency. Conclusions: These results suggest that under pulsed conditions, a lower energy consumption and lower perceived brightness could be achieved, thus potentially providing improved operating conditions for medical/infection control applications without compromising antimicrobial efficacy. PMID:27759498

  8. Efficacy of Pulsed 405-nm Light-Emitting Diodes for Antimicrobial Photodynamic Inactivation: Effects of Intensity, Frequency, and Duty Cycle.

    PubMed

    Gillespie, Jonathan B; Maclean, Michelle; Given, Martin J; Wilson, Mark P; Judd, Martin D; Timoshkin, Igor V; MacGregor, Scott J

    2017-03-01

    This study investigates possible advantages in pulsed over continuous 405-nm light-emitting diode (LED) light for bacterial inactivation and energy efficiency. Alternative nonantibiotic methods of disinfection and infection control have become of significant interest. Recent studies have demonstrated the application of systems using 405-nm LEDs for continuous disinfection of the clinical environment, and also for potential treatment of contaminated wounds. Liquid suspensions of 10(3) colony-forming units/mL populations of Staphylococcus aureus were subject to pulsed 405-nm light of different frequencies, duty cycles, and intensities and for different lengths of time. Pulsed exposures with the same average irradiance of 16 mW/cm(2) and varying duty cycle (25%, 50%, 75%) showed very similar performance compared with continuous exposures, with 95-98% reduction of S. aureus achieved for all duty cycles. The pulsing frequency was varied in intervals from 100 Hz to 10 kHz and appeared to have little effect on antimicrobial efficacy. However, when comparing pulsed with continuous exposure, an improvement in inactivation per unit optical energy was achieved, with results showing an increase of approximately 83% in optical efficiency. These results suggest that under pulsed conditions, a lower energy consumption and lower perceived brightness could be achieved, thus potentially providing improved operating conditions for medical/infection control applications without compromising antimicrobial efficacy.

  9. Effect of pulse repetition frequency of high-intensity focused ultrasound on in vitro thrombolysis.

    PubMed

    Yang, Wenjing; Zhou, Yufeng

    2017-03-01

    Vascular occlusion by the thrombi is the main reason for ischemic stroke and deep vein thrombosis. High-intensity focused ultrasound (HIFU) and histotripsy or microtripsy pulses can effectively dissolve the blood clot with no use of thrombolytic agent and ultrasound contrast agent (microbubbles). In this study, HIFU bursts at the same duty cycle (2%) but varied pulse repetition frequency (PRF) from 1Hz to 1000Hz were delivered to in vitro porcine blood clot for 30s. Thrombolysis efficiency initially increases slightly with the PRF, 86.4±10.3%, 89.9±11.9, and 92.9±12.8% at the PRF of 1Hz, 10Hz, and 100Hz, respectively, without significant difference (p>0.05), but then drops dramatically to 37.9±6.9% at the PRF of 1000Hz (p<0.05). The particle size in the supernatant of dissolution is 547.1±129.5nm, which suggests the disruption of thrombi into the subcellular level. Thrombi motion during HIFU exposure shows violent motion and significant curling at the low PRF, rotation about its axis with occasional curling at the moderate PRF, and localized vibration at the high PRF due to the generation of acoustic radiation force and streaming. Quantitative analysis of recorded motion shows the axial displacement decreases with the PRF of delivered HIFU bursts, from 3.9±1.5mm at 1Hz to 0.7±0.4mm at 1000Hz. Bubble cavitation during HIFU exposure to the blood clot was also monitored. The increase of PRF led to the increase of inertial cavitation but the decrease of stable cavitation. In summary, the PRF of delivered HIFU bursts at the same output energy has a significant effect on the thrombi motion, bubble cavitation activities, and subsequently thrombolysis efficiencies.

  10. Frequency-doubled dual-pulse freddy lithrotripsy laser in the treatment of urinary tract calculi

    NASA Astrophysics Data System (ADS)

    Huang, Xuyuan; Bo, Juanjie; Chen, Bin; Wang, Yi-Xin

    2005-07-01

    Background and Purpose: The Frequency-Doubled Dual-Pulse Nd:YAG FREDDY laser is a short-pulsed, solid-state laser with wavelengths of 532 and 1064 nm that was developed for intracorporeal lithothripsy. This clinical study is designed to test its fragmentation efficiency in the treatment of urinary tract calculi. Patients and Methods: 500 urinary tract calculi treated in 194 female and 306 male patients with a mean age of 46 years. All patients were assessed one week post-op with a plain film of the kidneys, ureters and bladder. Stone-free rate and final outcome have been evaluated. Final outcome is defined as stone-free or residual fragments. Analysis has been made according to stone size, location and number of stones. The analgesia requirements during each treatment and complications have also been analyzed. Results: The overall stone-free rate for patients was 92.4%. The success rate for upper ureteral was 85.1% (126/148), while the rate for mid/lower was 95.3% (307/322). Bladder stone success rate 96.6% (29/30). Of all 38 incomplete fragmentations, 20 cases (4%) were treated with ESWL and 18 cases (3.6%) had open surgery. Neither fever nor pyonephrosis was reported. The average laser treatment time was 3.3 minutes and the average post-op hospitalization was 2.5 days. Conclusions: The FREDDY laser is an extremely efficient and safe minimally invasive lithotripsy treatment for urinary stones. It should be considered as an alternative treatment for urolithiasis.

  11. NONLINEAR-OPTICS PHENOMENA: Formation of optical pulses by modulating the resonant quantum transition frequency in a spectrally inhomogeneous medium

    NASA Astrophysics Data System (ADS)

    Polovinkin, V. A.; Radionychev, E. V.

    2010-02-01

    We consider the conversion of monochromatic radiation in the case of resonant interaction with a quantum system under the condition of harmonic modulation of the quantum transition frequency by the action of additional nonresonant radiation due to the Stark or Zeeman effect, taking into account the inhomogeneous broadening of the quantum transition line. It is shown analytically and numerically that resonant radiation can be converted in a train of ultrashort pulses with a peak intensity exceeding manifold the incident wave intensity. The possibility of the additional compression of the produced pulses is studied by compensating the inherent frequency modulation in a medium with a quadratic or programmable dispersion. The optimal values of the radiation — matter interaction parameters are found numerically. It is shown that generation of femtosecond optical pulses of radiation quasi-resonant to the δ transition of the atomic hydrogen Balmer series is possible.

  12. Instantaneous frequency time analysis of physiology signals: The application of pregnant women’s radial artery pulse signals

    NASA Astrophysics Data System (ADS)

    Su, Zhi-Yuan; Wang, Chuan-Chen; Wu, Tzuyin; Wang, Yeng-Tseng; Tang, Feng-Cheng

    2008-01-01

    This study used the Hilbert-Huang transform, a recently developed, instantaneous frequency-time analysis, to analyze radial artery pulse signals taken from women in their 36th week of pregnancy and after pregnancy. The acquired instantaneous frequency-time spectrum (Hilbert spectrum) is further compared with the Morlet wavelet spectrum. Results indicate that the Hilbert spectrum is especially suitable for analyzing the time series of non-stationary radial artery pulse signals since, in the Hilbert-Huang transform, signals are decomposed into different mode functions in accordance with signal’s local time scale. Therefore, the Hilbert spectrum contains more detailed information than the Morlet wavelet spectrum. From the Hilbert spectrum, we can see that radial artery pulse signals taken from women in their 36th week of pregnancy and after pregnancy have different patterns. This approach could be applied to facilitate non-invasive diagnosis of fetus’ physiological signals in the future.

  13. The Effects of TM on Concurrent Heart Rate, Peripheral Blood Pulse Volume, and the Alpha Wave Frequency.

    ERIC Educational Resources Information Center

    Lukas, Jerome S.

    Through observation of 26 subjects over a 3 month period, this research project measured the effects of transcendental meditation (TM) on concurrent heart rate, peripheral blood pulse volume, and the alpha wave frequency. The subjects were assigned randomly to three groups. One group practiced TM as prescribed by the International Meditation…

  14. Optical frequency modulated pulse power losses, caused by optical fiber material dispersion

    NASA Astrophysics Data System (ADS)

    Ivanov, Dmitry V.; Ivanov, Vladimir A.; Ryabova, Natalia V.; Ryabova, Maria I.; Chernov, Andrei A.; Konkin, Nikita A.

    2017-04-01

    The equations were obtained to estimate the pulse power losses of broadband light pulses caused by material dispersion in an optical fiber. It was found that the dispersion caused by the extension of a signal bandwidth leads to decreasing a signal base as well as the noise immunity of a system, which uses broadband pulses.

  15. Spectral broadening measurement of the lower hybrid waves during long pulse operation in Tore Supra

    NASA Astrophysics Data System (ADS)

    Berger-By, G.; Decampy, J.; Antar, G. Y.; Goniche, M.; Ekedahl, A.; Delpech, L.; Leroux, F.; Tore Supra Team

    2014-02-01

    On many tokamaks (C-Mod, EAST, FTU, JET, HT-7, TS), a decrease in current drive efficiency of the Lower Hybrid (LH) waves is observed in high electron density plasmas. The cause of this behaviour is believed to be: Parametric Instabilities (PI) and Scattering from Density Fluctuations (SDF). For the ITER LH system, our knowledge must be improved to avoid such effects and to maintain the LH current drive efficiency at high density. The ITPA IOS group coordinates this effort [1] and all experimental data are essential to validate the numerical codes in progress. Usually the broadening of the LH wave frequency spectrum is measured by a probe located in the plasma edge. For this study, the frequency spectrum of a reflected power signal from the LH antenna was used. In addition, the spectrum measurements are compared with the density fluctuations observed on RF probes located at the antenna mouth. Several plasma currents (0.6 to 1.4 MA) and densities up to 5.2 × 1019 m-3 have been realised on Tore Supra (TS) long pulses and with high injected RF power, up to 5.4 MW-30s. This allowed using a spectrum analyser to make several measurements during the plasma pulse. The side lobe amplitude, shifted by 20-30MHz with respect to the main peak, grows with increasing density. Furthermore, for an increase of plasma current at the same density, the spectra broaden and become asymmetric. Some parametric dependencies are shown in this paper.

  16. Enhanced pulsar and single pulse detection via automated radio frequency interference detection in multipixel feeds

    NASA Astrophysics Data System (ADS)

    Kocz, J.; Bailes, M.; Barnes, D.; Burke-Spolaor, S.; Levin, L.

    2012-02-01

    Single pixel feeds on large aperture radio telescopes have the ability to detect weak (˜10 mJy) impulsive bursts of radio emission and sub-mJy radio pulsars. Unfortunately, in large-scale blind surveys, radio frequency interference (RFI) mimics both radio bursts and radio pulsars, greatly reducing the sensitivity to new discoveries as real signals of astronomical origin get lost among the millions of false candidates. In this paper a technique that takes advantage of multipixel feeds to use eigenvector decomposition of common signals is used to greatly facilitate radio burst and pulsar discovery. Since the majority of RFI occurs with zero dispersion, the method was tested on the total power present in the 13 beams of the Parkes multibeam receiver using data from archival intermediate-latitude surveys. The implementation of this method greatly reduced the number of false candidates and led to the discovery of one new rotating radio transient or RRAT, six new pulsars and five new pulses that shared the swept-frequency characteristics similar in nature to the `Lorimer burst'. These five new signals occurred within minutes of 11 previous detections of a similar type. When viewed together, they display temporal characteristics related to integer seconds, with non-random distributions and characteristic 'gaps' between them, suggesting they are not from a naturally occurring source. Despite the success in removing RFI, false candidates present in the data that are only visible after integrating in time or at non-zero dispersion remained. It is demonstrated that with some computational penalty, the method can be applied iteratively at all trial dispersions and time resolutions to remove the vast majority of spurious candidates.

  17. A micropower supervisor for wireless nodes with a digital pulse frequency modulator battery monitor

    NASA Astrophysics Data System (ADS)

    Carloni, Mirko; d'Aparo, Rocco; Scorrano, Pierpaolo; Naticchia, Berardo; Conti, Massimo

    2013-05-01

    In the last few years the increased development of wireless technologies led to the development of micropower devices with power management and real time power control, aimed to maximize the battery life time.1 The main and simplest method to estimate residual battery life time is by voltage measurement. This kind of measurement is simple but is useless in many cases, especially when long term Lithium-Thionyl chloride batteries are used, since its voltage is flat for more than 90% of the battery discharge. In this case, a current control should be used. However, these kinds of devices have various problems as a limited range of measurement and not negligible quiescent current that may distort the measurements. In this work we developed a micropower supervisor for wireless sensor nodes with a charge battery monitor, whose features are aimed at solving the problems just described. The current measured by a sense resistor, is filtered by a super-capacitor, amplified by a current sense amplifier and then fed to a voltage to pulse frequency modulator. In this way, the charge consumption can be estimated without the saturation of the current sense amplifier, even if the wireless node consumes time limited high current spikes, for example during transmission.

  18. Frequency-locked pulse sequencer for high-frame-rate monochromatic tissue motion imaging.

    PubMed

    Azar, Reza Zahiri; Baghani, Ali; Salcudean, Septimiu E; Rohling, Robert

    2011-04-01

    To overcome the inherent low frame rate of conventional ultrasound, we have previously presented a system that can be implemented on conventional ultrasound scanners for high-frame-rate imaging of monochromatic tissue motion. The system employs a sector subdivision technique in the sequencer to increase the acquisition rate. To eliminate the delays introduced during data acquisition, a motion phase correction algorithm has also been introduced to create in-phase displacement images. Previous experimental results from tissue- mimicking phantoms showed that the system can achieve effective frame rates of up to a few kilohertz on conventional ultrasound systems. In this short communication, we present a new pulse sequencing strategy that facilitates high-frame-rate imaging of monochromatic motion such that the acquired echo signals are inherently in-phase. The sequencer uses the knowledge of the excitation frequency to synchronize the acquisition of the entire imaging plane to that of an external exciter. This sequencing approach eliminates any need for synchronization or phase correction and has applications in tissue elastography, which we demonstrate with tissue-mimicking phantoms.

  19. Detection of hypervelocity impact radio frequency pulses through prior constrained source separation

    NASA Astrophysics Data System (ADS)

    Nuttall, Andrew; Kochenderfer, Mykel; Close, Sigrid

    2016-10-01

    Hypervelocity dust impacts produce electromagnetic pulses in the radio frequency (RF) spectrum that scales with impactor mass and velocity. Due to the mass acceleration limitations of ground-based facilities, detecting emissions from impacts in a laboratory setup is difficult due to their low output power. This paper presents a general probabilistic technique to perform signal excision, which was applied to synthetic and hypervelocity impact data sets. The task of excising multiple signals from a single observation of their mixtures is referred to as underdetermined blind source separation (BSS). This paper introduces a framework for solving underdetermined BSS problems when there is only one observation signal by leveraging often overlooked prior information. The most probable solutions for the source signals are computed by solving an iterative constrained optimization problem that seeks to maximize the posterior probability of the system model. In the hypervelocity impact data set, the goal was to reduce the noise floor on an RF antenna by modeling and extracting exterior sources of noise. It was found that the algorithm described in this paper was able to model signals in the observation and subtract them while still maintaining the spectral and temporal content of the remaining signals. Through the use of this methodology, previously hidden impact emissions were able to be isolated and identified for further characterization.

  20. Changes in peripheral blood levels and pulse frequencies of GnRH in patients with hypopituitarism.

    PubMed

    Hayashi, M; Takanashi, N; Yaoi, Y

    1998-09-01

    Pituitary dysfunction occasionally results from brain tumors or the surgical resection of brain tumors. The authors examined two patients with hypogonadotropic secondary amenorrhea, who had undergone surgical removal of brain tumors. Changes in immunoreactive gonadotropin-releasing hormone (GnRH) secretion are of interest in patients with a gonadotropin and gonadal steroid deficit, because both steroid and pituitary feedback systems are altered by tumors or tumor resection. The authors thus measured GnRH, luteinizing hormone, and follicle-stimulating hormone levels every 15 minutes for 4 hours by radioimmunoassay and investigated qualitative and quantitative changes in the pulsatile patterns of these hormones in two hypogonadotropic hypogonadism patients. They also performed similar multiple measurements of GnRH in two normal cycle women in follicular phase and two postmenopausal women. The concentration of plasma GnRH in two hypopituitarism patients was compared with that in two normal cycle women and two postmenopausal women. The study showed that the peripheral blood level of GnRH was significantly lower in two hypopituitarism patients than in both normal cycle and postmenopausal women, and that the pulsatile frequency was not different among these three groups. These findings suggest that alteration of feedback systems results in a decrease in the blood level of GnRH, and that pulses of GnRH maintain normal fluctuation despite the alteration of the hormonal circumstances in two hypogonadotropic hypogonadism patients.

  1. Dual Data Pulse Width Modulator for Radio Frequency Identification Biosensor Signal Modulation

    NASA Astrophysics Data System (ADS)

    Kim, Boram; Nakazato, Kazuo

    2013-04-01

    A dual data pulse width modulator is proposed and demonstrated for radio frequency identification (RFID) biosensor signal modulation. Simultaneous wireless measurement of two sensors can be carried out using this circuit, in which two analog signals are modulated and transmitted in a single clock cycle. The measured modulation sensitivity of the two input channels is 84.69 and 85.16 µs/V and the dynamic range is 55.6 and 63.5 dB, respectively. Here, redox potential and temperature are measured wirelessly using the proposed circuit. Temperature change measurement shows a sensitivity of 9.501 µs/°C in the range of 25-40 °C. The measured redox potential shows fairly good linearity for a concentration ratio of hexacyanoferrate (III) to (II) ranging from 10-2 to 102 and the slope is 58.0 mV/decade, almost the same as the theoretical value. The chip area and power consumption are 0.36 mm2 and 650 µW, respectively, using 1.2-µm, 2-metal, 2-poly CMOS technology.

  2. Neuroprotective Effect of Low Frequency-Pulsed Electromagnetic Fields in Ischemic Stroke.

    PubMed

    Urnukhsaikhan, Enerelt; Mishig-Ochir, Tsogbadrakh; Kim, Soo-Chan; Park, Jung-Keug; Seo, Young-Kwon

    2017-04-01

    Low frequency-pulsed electromagnetic fields (LF-PEMFs) affect many biological processes; however, the fundamental mechanisms responsible for these effects remain unclear. Our study aimed to investigate the effect of LF-PEMFs on neuroprotection after ischemic stroke. C57B6 mice were exposed to LF-PEMF (F = 60 Hz, Bm = 10 mT) after photothrombotic occlusion. We measured the BDNF/TrkB/Akt signaling pathway, pro-apoptotic and pro-survival protein and gene expressions, and the expression of inflammatory mediators and performed behavioral tests in both LF-PEMF-treated and untreated ischemic stroke mice. Our results showed that LF-PEMF treatment promotes activation of the BDNF/TrkB/Akt signaling pathway. Subsequently, pro-survival proteins were significantly increased, while pro-apoptotic proteins and inflammatory mediators were decreased in ischemic stroke mice after LF-PEMF treatment. The results demonstrated that LF-PEMF exposure has a neuroprotective effect after ischemic stroke in mice during the recovery process.

  3. Kisspeptin, Neurokinin B, and Dynorphin Act in the Arcuate Nucleus to Control Activity of the GnRH Pulse Generator in Ewes

    PubMed Central

    Hileman, Stanley M.; Nestor, Casey C; Porter, Katrina L.; Connors, John M.; Hardy, Steve L.; Millar, Robert P.; Cernea, Maria; Coolen, Lique M.; Lehman, Michael N.

    2013-01-01

    Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy) neurons in the arcuate nucleus play a key role in GnRH pulse generation, with kisspeptin driving GnRH release and neurokinin B (NKB) and dynorphin acting as start and stop signals, respectively. In this study, we tested this hypothesis by determining the actions, if any, of four neurotransmitters found in KNDy neurons (kisspeptin, NKB, dynorphin, and glutamate) on episodic LH secretion using local administration of agonists and antagonists to receptors for these transmitters in ovariectomized ewes. We also obtained evidence that GnRH-containing afferents contact KNDy neurons, so we tested the role of two components of these afferents: GnRH and orphanin-FQ. Microimplants of a Kiss1r antagonist briefly inhibited LH pulses and microinjections of 2 nmol of this antagonist produced a modest transitory decrease in LH pulse frequency. An antagonist to the NKB receptor also decreased LH pulse frequency, whereas NKB and an antagonist to the receptor for dynorphin both increased pulse frequency. In contrast, antagonists to GnRH receptors, orphanin-FQ receptors, and the N-methyl-D-aspartate glutamate receptor had no effect on episodic LH secretion. We thus conclude that the KNDy neuropeptides act in the arcuate nucleus to control episodic GnRH secretion in the ewe, but afferent input from GnRH neurons to this area does not. These data support the proposed roles for NKB and dynorphin within the KNDy neural network and raise the possibility that kisspeptin contributes to the control of GnRH pulse frequency in addition to its established role as an output signal from KNDy neurons that drives GnRH pulses. PMID:23959940

  4. Study on the mode-transition of nanosecond-pulsed dielectric barrier discharge between uniform and filamentary by controlling pressures and pulse repetition frequencies

    NASA Astrophysics Data System (ADS)

    Yu, S.; Pei, X.; Hasnain, Q.; Nie, L.; Lu, X.

    2016-02-01

    In this paper, we investigate the temporally resolved evolution of the nanosecond pulsed dielectric barrier discharge (DBD) in a moderate 6 mm discharge gap under various pressures and pulse repetition frequencies (PRFs) by intensified charge-coupled device (ICCD) images, using dry air and its components oxygen and nitrogen. It is found that the pressures are very different when the mode transits between uniform and filamentary in air, oxygen, and nitrogen. The PRFs can also obviously affect the mode-transition. The transition mechanism in the pulsed DBD is not Townsend-to-Streamer, which is dominant in the traditional alternating-voltage DBD. The pulsed DBD in a uniform mode develops in the form of plane ionization wave due to overlap of primary avalanches, while the increase in pressure disturbs the overlap and discharge develops in streamer, corresponding to the filamentary mode. Increasing the initial electron density by pre-ionization may contribute to discharge uniformity at higher pressures. We also found that the dependence of homogeneity upon PRF is a non-monotonic one.

  5. Study on the mode-transition of nanosecond-pulsed dielectric barrier discharge between uniform and filamentary by controlling pressures and pulse repetition frequencies

    NASA Astrophysics Data System (ADS)

    Yu, Sizhe; Lu, Xinpei

    2016-09-01

    We investigate the temporally resolved evolution of the nanosecond pulsed dielectric barrier discharge (DBD) in a moderate 6mm gap under various pressures and pulse repetition frequencies (PRFs) by intensified charge-coupled device (ICCD) images, using synthetic air and its components oxygen and nitrogen. It is found that the pressures are very different when the DBD mode transits between uniform and filamentary in air, oxygen, and nitrogen. The PRFs can also obviously affect the mode-transition. The transition mechanism in the pulsed DBD is not Townsend-to-streamer, which is dominant in the traditional alternating-voltage DBDs. The pulsed DBD in a uniform mode develops in the form of plane ionization wave, due to overlap of primary avalanches, while the increase in pressure disturbs the overlap and DBD develops in streamer instead, corresponding to the filamentary mode. Increasing the initiatory electron density by pre-ionization methods may contribute to discharge uniformity at higher pressures. We also find that the dependence of uniformity upon PRF is non-monotonic.

  6. Studies on gas breakdown in pulsed radio frequency atmospheric pressure glow discharges

    SciTech Connect

    Huo, W. G.; Jian, S. J.; Yao, J.; Ding, Z. F.

    2014-05-15

    In pulsed RF atmospheric pressure glow discharges, the gas breakdown judged by the rapid drop in the amplitude of the pulsed RF voltage is no longer universally true. The steep increment of the plasma-absorbed RF power is proposed to determine the gas breakdown. The averaged plasma-absorbed RF power over a pulse period is used to evaluate effects of the preceding pulsed RF discharge on the breakdown voltage of the following one, finding that the breakdown voltage decreases with the increment in the averaged plasma-absorbed RF power under constant pulse duty ratio. Effects of the pulse off-time on the breakdown voltage and the breakdown delay time are also studied. The obtained dependence of the breakdown voltage on the pulse off-time is indicative of the transitional plasma diffusion processes in the afterglow. The breakdown voltage varies rapidly as the plasma diffuses fast in the region of moderate pulse off-time. The contribution of nitrogen atom recombination at the alumina surface is demonstrated in the prolonged memory effect on the breakdown delay time vs. the pulse off-time and experimentally validated by introducing a trace amount of nitrogen into argon at short and long pulse off-times.

  7. INTERACTION OF LASER RADIATION WITH MATTER: Absorption of a femtosecond laser pulse by metals and the possibility of determining effective electron—electron collision frequencies

    NASA Astrophysics Data System (ADS)

    Isakov, Vladimir A.; Kanavin, Andrey P.; Uryupin, Sergey A.

    2006-10-01

    A method is proposed for describing absorption of an electron-heating femtosecond laser pulse that interacts with a metal under conditions of high-frequency skin effect. It is shown that the effective frequencies of electron—electron collisions accompanied by umklapp processes can be determined by measuring the absorption or reflection coefficients of a femtosecond pulse.

  8. Optimization of contrast-to-tissue ratio through pulse windowing in dual-frequency “acoustic angiography” imaging

    PubMed Central

    Lindsey, Brooks D.; Shelton, Sarah E.; Dayton, Paul A.

    2016-01-01

    Early-stage tumors in many cancers are characterized by vascular remodeling, indicative of transformations in cell function. We have previously presented a high-resolution ultrasound imaging approach for detecting these changes which is based on microbubble contrast agents. In this technique, images are formed from only the higher harmonics of microbubble contrast agents, producing images of vasculature alone with 100–200 μm resolution. In this article, shaped transmit pulses are applied to imaging the higher broadband harmonic echoes of microbubble contrast agents, and the effects of varying pulse window and phasing on microbubble and tissue harmonic echoes are evaluated using a dual-frequency transducer in vitro and in vivo. An increase in contrast-to-tissue ratio of 6.8 ± 2.3 dB was observed in vitro by using an inverted pulse with a cosine window relative to a non-inverted pulse with a rectangular window. The increase in mean image intensity due to contrast enhancement in vivo in five rodents was 13.9 ± 3.0 dB greater for an inverted cosine-windowed pulse and 17.8 ± 3.6 dB greater for a non-inverted Gaussian-windowed relative to a non-inverted pulse with a rectangular window. Implications for pre-clinical and diagnostic imaging are also discussed. PMID:25819467

  9. Dual-frequency tissue harmonic suppression using phase-coded pulse sequence: proof of concept using a phantom.

    PubMed

    Shen, Che-Chou; Wang, Hui-Ting

    2013-03-01

    The presence of tissue harmonic generation during acoustic propagation is one major limitation in nonlinear detection of microbubble contrast agents. However, conventional solutions for tissue harmonic suppression are not applicable in dual-frequency (DF) harmonic imaging. In DF harmonic imaging, the second harmonic signal at second harmonic (2f(0)) frequency and the inter-modulation harmonic signal at fundamental (f(0)) frequency are simultaneously generated for imaging and both need to be suppressed to improve contrast-to-tissue ratio (CTR). In this study, a novel phase-coded pulse sequence is developed to accomplish DF tissue harmonic suppression. Phase-coded pulse sequence utilizes multiple firings with equidistant transmit phase for harmonic cancellation in the sum of respective echoes. For the f(0) transmit component, the transmit phase comes from the equidistant set of {-2π/3, 0, 2π/3} to suppress the second harmonic signal at 2f(0) frequency. Moreover, in order to provide the inter-modulation harmonic suppression at f(0) frequency, the 2f(0) transmit phase has to be particularly manipulated for the corresponding f(0) transmit phase. The proposed three-pulse sequence can remove not only the second-order harmonic signal but also other higher-order counterparts at both f(0) and 2f(0) frequencies. Measurements were performed at f(0) equal to 2.25 MHz and using hydrophone in water and contrast agents in tissue phantom. Experimental results indicate that the sequence reduces the tissue harmonic magnitude by about 20 dB along the entire axial depths and the corresponding CTR improves at both frequencies. In DF harmonic imaging, the proposed phase-coded sequence can effectively remove the tissue harmonic background at both f(0) and 2f(0) frequencies for improvement of contrast detection. Copyright © 2012 Elsevier B.V. All rights reserved.

  10. Comment on 'Photoplethysmography sampling frequency: pilot assessment of how low can we go to analyze pulse rate variability with reliability?'

    PubMed

    Hejjel, László

    2017-10-12

    Accurate pulse rate detection is essential for reliable pulse rate variability analysis. On the other hand, minimizing the sampling frequency is essential to reduce the amounts of data and computational needs, and consequently power consumption of mobile/wearable devices extending their operating hours. Determining variability of physiological parameters needs a new paradigm since there is a limited possibility of calculating an average eliminating random error of measurement. Finding the optimal sampling rate depends on the actual investigation, the expected variability and variability-changes of the study-population. © 2017 Institute of Physics and Engineering in Medicine.

  11. Time division approach to separate overlapped interference fringes of multiple pulse trains of femtosecond optical frequency comb for length measurement

    NASA Astrophysics Data System (ADS)

    Wei, Dong; Aketagawa, Masato

    2017-01-01

    In this study, we attempt the separation of overlapped interference fringes arising from multiple pulse trains of a femtosecond optical frequency comb for length measurement. Based on an optical experiment, we test the performance of the separation of two overlapped interference fringes by time division for an absolute length measurement, which is about one adjacent pulse repetition interval length. We compare our results with those of a commercial He-Ne interferometer system. The two sets of results show an agreement within 0.7 μm.

  12. Chirped pulse heterodyne for optimal beat note detection between a frequency comb and a continuous wave laser.

    PubMed

    Deschênes, Jean-Daniel; Genest, Jérôme

    2015-04-06

    Chirped pulse heterodyne is proposed to maximize the signal-to-noise ratio (SNR) when measuring the beat note between an optical frequency comb and a continuous wave (CW) laser. The noise model reveals that all the comb power within the largest possible detection bandwidth can be used to increase the SNR. The chirped comb/CW interference experiment is shown to be equivalent to CW/CW interference, using the comb's spectrally available power. The approach can also greatly alleviate dynamic range issues when detected pulsed heterodyne signals. A beat note SNR of 68.3 dB in a 100 kHz bandwidth is achieved.

  13. Frequency modulation and compression of optical pulses in an optical fibre with a travelling refractive-index wave

    SciTech Connect

    Zolotovskii, I O; Lapin, V A; Sementsov, D I

    2016-01-31

    We have studied the conditions for spectral broadening, frequency modulation and compression (both temporal and spectral) of Gaussian pulses propagating in a fibre with a travelling refractive-index wave. Analytical expressions have been derived for the dependences of pulse duration, chirp and spectral width on the distance travelled through the fibre, parameters of the fibre and radiation launched into it. Based on the numerical analysis we have studied the behaviour of these characteristics by changing the coefficient of the refractive-index modulation and other parameters of the travelling refractive-index wave. (nonlinear optical phenomena)

  14. 3-D Surface Depression Profiling Using High Frequency Focused Air-Coupled Ultrasonic Pulses

    NASA Technical Reports Server (NTRS)

    Roth, Don J.; Kautz, Harold E.; Abel, Phillip B.; Whalen, Mike F.; Hendricks, J. Lynne; Bodis, James R.

    1999-01-01

    Surface topography is an important variable in the performance of many industrial components and is normally measured with diamond-tip profilometry over a small area or using optical scattering methods for larger area measurement. This article shows quantitative surface topography profiles as obtained using only high-frequency focused air-coupled ultrasonic pulses. The profiles were obtained using a profiling system developed by NASA Glenn Research Center and Sonix, Inc (via a formal cooperative agreement). (The air transducers are available as off-the-shelf items from several companies.) The method is simple and reproducible because it relies mainly on knowledge and constancy of the sound velocity through the air. The air transducer is scanned across the surface and sends pulses to the sample surface where they are reflected back from the surface along the same path as the incident wave. Time-of-flight images of the sample surface are acquired and converted to depth/surface profile images using the simple relation (d = V*t/2) between distance (d), time-of-flight (t), and the velocity of sound in air (V). The system has the ability to resolve surface depression variations as small as 25 microns, is useable over a 1.4 mm vertical depth range, and can profile large areas only limited by the scan limits of the particular ultrasonic system. (Best-case depth resolution is 0.25 microns which may be achievable with improved isolation from vibration and air currents.) The method using an optimized configuration is reasonably rapid and has all quantitative analysis facilities on-line including 2-D and 3-D visualization capability, extreme value filtering (for faulty data), and leveling capability. Air-coupled surface profilometry is applicable to plate-like and curved samples. In this article, results are shown for several proof-of-concept samples, plastic samples burned in microgravity on the STS-54 space shuttle mission, and a partially-coated cylindrical ceramic

  15. Point source of UV-radiation with a frequency of 1 khz and short pulse duration

    NASA Astrophysics Data System (ADS)

    Baksht, E. Kh.; Tarasenko, V. F.; Shut'ko, Yu. V.; Erofeev, M. V.

    2012-04-01

    Radiation of the discharge plasma from a nanosecond breakdown in a nonuniform electric field of short interelectrode gaps is investigated. Voltage pulses with incident wave amplitude of ~10 kV, pulse duration of ~1 ns (FWHM), and pulse front duration of ~0.2 ns are used. It is demonstrated that for pulsed-periodic breakdown of the gap 0.5 mm long in air at atmospheric pressure, the main contribution to plasma radiation give lines of the electrode material and the continuum, and the maximum radiation intensity is registered in the region of 200-300 nm, where ~40% of total radiation energy is concentrated.

  16. Measurement and control of the frequency chirp rate of high-order harmonic pulses

    SciTech Connect

    Mauritsson, J.; Johnsson, P.; Lopez-Martens, R.; Varju, K.; L'Huillier, A.; Kornelis, W.; Biegert, J.; Keller, U.; Gaarde, M.B.; Schafer, K.J.

    2004-08-01

    We measure the chirp rate of harmonics 13 to 23 in argon by cross correlation with a 12 femtosecond probe pulse. Under low ionization conditions, we directly measure the negative chirp due to the atomic dipole phase, and show that an additional chirp on the pump pulse is transferred to the qth harmonic as q times the fundamental chirp. Our results are in accord with simulations using the experimentally measured 815 nm pump and probe pulses. The ability to measure and manipulate the harmonic chirp rate is essential for the characterization and optimization of attosecond pulse trains.

  17. Influence of Pulse Repetition Frequency on 3-D Power Doppler Quantification.

    PubMed

    Soares, Carlos A M; Pavan, Theo Z; Miyague, Andre H; Kudla, Marek; Martins, Wellington P

    2016-12-01

    Three-dimensional power Doppler quantification has limited application because of its high dependency on attenuation. The purpose of the study described here was to assess if different degrees of attenuation, depending on pulse repetition frequency (PRF) adjustment, alter 3-D power Doppler quantification in a region of 100% moving blood when using vascularization index, flow index and vascularization flow index (VFI). A cubic-shaped gelatin phantom with a 1.8-mm-internal-diameter silicon tube was used. The tube, placed at 45° to the phantom's surface, was filled with blood-mimicking fluid with as constant maximum velocity of 30 cm/s. Two different attenuation blocks (low and high attenuation) were alternatively placed between the phantom and the transvaginal transducer. One single observer acquired 10 data sets for each PRF level from 0.3 to 7.5 kHz, using the high- and low-attenuation blocks, for a total of 200 3-D power Doppler data sets. We assessed VFI from 1.5-mm-diameter spherical samples, virtually placed inside the tube, always at the same position. No difference was noted between high- and low-attenuation VFI values when using a PRF of 0.3 kHz. As PRF increased, it was observed that VFI quantification progressively differed between low and high attenuation. Also, a slope on VFI values for both high- and low-attenuation models could be observed when increasing PRF, particularly above 4.0 kHz. We concluded that PRF adjustment is very relevant when using VFI to quantify 3-D power Doppler signal.

  18. Generation of optical frequency combs in fibres: an optical pulse analysis

    NASA Astrophysics Data System (ADS)

    Zajnulina, Marina; Böhm, Michael; Blow, Keith; Chavez Boggio, José M.; Rieznik, Andres A.; Haynes, Roger; Roth, Martin M.

    2014-07-01

    The innovation of optical frequency combs (OFCs) generated in passive mode-locked lasers has provided astronomy with unprecedented accuracy for wavelength calibration in high-resolution spectroscopy in research areas such as the discovery of exoplanets or the measurement of fundamental constants. The unique properties of OCFs, namely a highly dense spectrum of uniformly spaced emission lines of nearly equal intensity over the nominal wavelength range, is not only beneficial for high-resolution spectroscopy. Also in the low- to medium-resolution domain, the OFCs hold the promise to revolutionise the calibration techniques. Here, we present a novel method for generation of OFCs. As opposed to the mode-locked laser-based approach that can be complex, costly, and difficult to stabilise, we propose an all optical fibre-based system that is simple, compact, stable, and low-cost. Our system consists of three optical fibres where the first one is a conventional single-mode fibre, the second one is an erbium-doped fibre and the third one is a highly nonlinear low-dispersion fibre. The system is pumped by two equally intense continuous-wave (CW) lasers. To be able to control the quality and the bandwidth of the OFCs, it is crucial to understand how optical solitons arise out of the initial modulated CW field in the first fibre. Here, we numerically investigate the pulse evolution in the first fibre using the technique of the solitons radiation beat analysis. Having applied this technique, we realised that formation of higherorder solitons is supported in the low-energy region, whereas, in the high-energy region, Kuznetsov-Ma solitons appear.

  19. Non-ablative scar revision using a long pulsed frequency doubled Nd:YAG laser.

    PubMed

    Cassuto, Daniel; Emanuelli, Guglielmo

    2003-12-01

    Unsightly scars often are the only reminder of a previous surgical or traumatic wound. Surgical or ablative scar revision is sought by patients, sometimes unnecessarily. When the aesthetic drawback is mainly a result of hypervascularity or hyperpigmentation, these problems can be specifically targeted with a wavelength that is well absorbed by the two above mentioned chromophores. Some degree of epidermal tightening can also be achieved, which is sometimes useful in slightly atrophic scars. The average improvement after 2-3 sessions was 81% (75%-100%) clearance, as judged by an independent observer who reviewed pre- and post-treatment photographs. No undesired effects were reported. All our patients were satisfied and required no further treatment. Selective photothermolysis by means of a long pulsed frequency doubled Nd:YAG laser (DioLite 532, IRIDEX Corporation, Mountain View, CA, USA) was used to eliminate the unsightly vascular and pigmented components of 23 mature scars (scars older than 2 years) in 22 consecutive patients. Energy densities of 17-22 j/cm2 were used with a 500 micron spot, or 65-90 j/cm2 with a 200 micron spot. overall scar clearance averaged 81% after 2.4 treatments. Facial scars showed the best clearance averaging 94% after 2 treatments. Inframammary scars were the most difficult to clear averaging 46%. Postoperative undesired effects were immediate erythema and swelling that subsided within 2-10 hours and microcrusting on 19/22 (88%) patients that resolved within one week. No other temporary or permanent undesired effects such as purpura, hypo- or hyperpigmentation were noticed, even in patients with darker skin types.

  20. Definition of Shifts of Optical Transitions Frequencies due to Pulse Perturbation Action by the Photon Echo Signal Form

    NASA Astrophysics Data System (ADS)

    Lisin, V. N.; Shegeda, A. M.; Samartsev, V. V.

    2015-09-01

    A relative phase shift between the different groups of excited dipoles, which appears as result of its frequency splitting due to action of a pulse of electric or magnetic fields, depends on a time, if the pulse overlaps in time with echo-pulse. As а consequence, the echo waveform is changed. The echo time form is modulated. The inverse modulation period well enough approximates Zeeman and pseudo-Stark splitting in the cases of magnetic and, therefore, electrical fields. Thus the g-factors of ground 4I15/2 and excited 4F9/2 optical states of Er3+ ion in LuLiF4 and YLiF4 have been measured and pseudo-Stark shift of R1 line in ruby has been determined.

  1. Temporal characterization of mid-IR free-electron-laser pulses by frequency-resolved optical gating

    SciTech Connect

    Richman, B.A.; Krumbuegel, M.A.; Trebino, R.

    1997-05-01

    We performed what we believe are the first practical full-temporal-characterization measurements of ultrashort pulses from a free-electron laser (FEL). Second-harmonic-generation frequency-resolved optical gating (FROG) was used to measure a train of mid-IR pulses distorted by a saturated water-vapor absorption line and showing free-induction decay. The measured direction of time was unambiguous because of prior knowledge regarding free-induction decay. These measurements require only 10{percent} of the power of the laser beam and demonstrate that FROG can be implemented as a pulse diagnostic simultaneously with other experiments on a FEL. {copyright} {ital 1997} {ital Optical Society of America}

  2. Sodium temperature lidar based on injection seeded Nd:YAG pulse lasers using a sum-frequency generation technique.

    PubMed

    Kawahara, Takuya D; Kitahara, Tsukasa; Kobayashi, Fumitoshi; Saito, Yasunori; Nomura, Akio

    2011-02-14

    We report on a sodium (Na) temperature lidar based on two injection seeded Nd:YAG pulse lasers using single-pass sum-frequency generation. The laser power at 589 nm is 400 mW (40 mJ per pulse at a repetition rate of 10 Hz) and the pulse width is 22 nsec FWHM. The narrowband laser tuned to the Doppler broadened Na D2 spectrum enables us to measure the temperature of the mesopause region (80-115 km). This solid-state transportable system demonstrated high performance and capability at Syowa Station in Antarctica for 3 years and at Uji in Japan for an additional year without any major operational troubles.

  3. Estimation of Arterial Stiffness by Time-Frequency Analysis of Pulse Wave

    NASA Astrophysics Data System (ADS)

    Saito, Masashi; Yamamoto, Yuya; Shibayama, Yuka; Matsukawa, Mami; Watanabe, Yoshiaki; Furuya, Mio; Asada, Takaaki

    2011-07-01

    Evaluation of a pulse wave is effective for the early diagnosis of arteriosclerosis because the pulse wave contains the reflected wave that is the age- and stiffness-dependent component. In this study, we attempted to extract the parameter reflecting the component by pulse wave analysis using continuous wavelet transform. The Morlet wavelet was used as the mother wavelet. We then investigated the relationship between the parameter and the reflected wave that was extracted from the pulse wave by our previously reported separation technique. Consequently, the result of wavelet transform of the differentiated pulse waveform changed markedly owing to age and had medium correlation with the peak of the reflected wave (R=0.68).

  4. A novel measuring implementation of femtosecond pulse amplitude and phase based on frequency-resolved optical gating

    NASA Astrophysics Data System (ADS)

    Liu, Chunping; Ruan, Shuang-chen; Liu, Chengxiang; Long, Jinhua

    2005-01-01

    A novel measuring implementation based on second-harmonic generation frequency-resolved optical gating (SHG-FROG) has been presented. Both the intensity and phase of arbitrary-shaped ultra-short laser pulses can be got. According to SHG-FROG, the femtosecond pulse produced by a laser resource is split into two beams which variable time delay one another is controlled by a stepped electromotor. The second-harmonic signal field is generated by focusing these two beams to a 100um BBO crystal. Changing the delay from 0 to N (N is the samples number of time domain or frequency domain) delay units, the two-dimensional spectrum data of the second-harmonic signal field are acquired by PC2000-ISA card spectrometer and OOIwinIP of Ocean Optics. These data are provided to a pulse amplitude and phase retrieval algorithm to retrieve the parameters of the pulse. An experimental system is erected and the all software modules, including spectrum data acquiring, pulse retrieving and displaying, are based on Labwindows/CVI of National Instrument Corp. The stepped electromotor is driven by the commands coming from RS-232 interface. The results show that after 50 times iterations or so, the iterative error of the algorithm can be reduced to an enough small value and then the pulse amplitude, phase and other parameters are the desired parameters. The whole measuring process can be finished in 2~3 seconds while the spectrum data is a 64x64 matrix and the iterative times are set to 50.

  5. Parallel Electron Force Balance and the L-H Transition

    NASA Astrophysics Data System (ADS)

    Stoltzfus-Dueck, T.; Diallo, A.; Zweben, S.; Banerjee, S.

    2016-10-01

    In a popular description of the L-H transition, energy transfer to the mean flows directly depletes turbulence fluctuation energy, resulting in suppression of the turbulence and a corresponding transport bifurcation. However, electron parallel force balance couples nonzonal velocity fluctuations with electron pressure fluctuations on rapid timescales, comparable with the electron transit time. For this reason, energy in the nonzonal velocity stays in a fairly fixed ratio to electron thermal free energy, at least for frequency scales much slower than electron transit. In order for direct depletion of the energy in turbulent fluctuations to cause the L-H transition, energy transfer via Reynolds stress must therefore drain enough energy to significantly reduce the sum of the free energy in nonzonal velocities and electron pressure fluctuations. At low k⊥, the electron thermal free energy is much larger than the energy in nonzonal velocities, posing a stark challenge for this model of the L-H transition. Work supported by U.S. DoE contract #DE-AC02-09CH11466.

  6. Fluorescence Spectroscopy of Conformational Changes of Single LH2 Complexes

    PubMed Central

    Rutkauskas, Danielis; Novoderezhkin, Vladimir; Cogdell, Richard J.; van Grondelle, Rienk

    2005-01-01

    We have investigated the energy landscape of the bacterial photosynthetic peripheral light-harvesting complex LH2 of purple bacterium Rhodopseudomonas acidophila by monitoring sequences of fluorescence spectra of single LH2 assemblies, at room temperature, with different excitation intensities as well as at elevated temperatures, utilizing a confocal microscope. The fluorescence peak wavelength of individual LH2 complexes was found to abruptly move between long-lived quasi-stable levels differing by up to 30 nm. The frequency and size of these fluorescence peak movements were found to increase linearly with the excitation intensity. These spectral shifts either to the blue or to the red were accompanied by a broadening and decrease of the intensity of the fluorescence spectrum. The probability for a particle to undergo significant spectral shift in either direction was found to be roughly the same. Using the modified Redfield theory, the observed changes in spectral shape and intensity were accounted for by changes in the realization of the static disorder. Long lifetimes of the quasi-stable states suggest large energetic barriers between the states characterized by different emission spectra. PMID:15501944

  7. Parallel electron force balance and the L-H transition

    SciTech Connect

    Stoltzfus-Dueck, T.

    2016-05-23

    In one popular paradigm for the L-H transition, energy transfer to the mean flows directly depletes turbulence fluctuation energy, resulting in suppression of the turbulence and a corresponding transport bifurcation. To quantitatively evaluate this mechanism, one must remember that electron parallel force balance couples nonzonal velocity fluctuations with electron pressure fluctuations on rapid timescales, comparable with the electron transit time. For this reason, energy in the nonzonal velocity stays in a fairly fixed ratio to the free energy in electron density fluctuations, at least for frequency scales much slower than electron transit. Furthermore, in order for direct depletion of the energy in turbulent fluctuations to cause the L-H transition, energy transfer via Reynolds stress must therefore drain enough energy to significantly reduce the sum of the free energy in nonzonal velocities and electron pressure fluctuations. At low k⊥, the electron thermal free energy is much larger than the energy in nonzonal velocities, posing a stark challenge for this model of the L-H transition.

  8. Parallel electron force balance and the L-H transition

    SciTech Connect

    Stoltzfus-Dueck, T.

    2016-05-23

    In one popular paradigm for the L-H transition, energy transfer to the mean flows directly depletes turbulence fluctuation energy, resulting in suppression of the turbulence and a corresponding transport bifurcation. To quantitatively evaluate this mechanism, one must remember that electron parallel force balance couples nonzonal velocity fluctuations with electron pressure fluctuations on rapid timescales, comparable with the electron transit time. For this reason, energy in the nonzonal velocity stays in a fairly fixed ratio to the free energy in electron density fluctuations, at least for frequency scales much slower than electron transit. Furthermore, in order for direct depletion of the energy in turbulent fluctuations to cause the L-H transition, energy transfer via Reynolds stress must therefore drain enough energy to significantly reduce the sum of the free energy in nonzonal velocities and electron pressure fluctuations. At low k⊥, the electron thermal free energy is much larger than the energy in nonzonal velocities, posing a stark challenge for this model of the L-H transition.

  9. Parallel electron force balance and the L-H transition

    DOE PAGES

    Stoltzfus-Dueck, T.

    2016-05-23

    In one popular paradigm for the L-H transition, energy transfer to the mean flows directly depletes turbulence fluctuation energy, resulting in suppression of the turbulence and a corresponding transport bifurcation. To quantitatively evaluate this mechanism, one must remember that electron parallel force balance couples nonzonal velocity fluctuations with electron pressure fluctuations on rapid timescales, comparable with the electron transit time. For this reason, energy in the nonzonal velocity stays in a fairly fixed ratio to the free energy in electron density fluctuations, at least for frequency scales much slower than electron transit. Furthermore, in order for direct depletion of themore » energy in turbulent fluctuations to cause the L-H transition, energy transfer via Reynolds stress must therefore drain enough energy to significantly reduce the sum of the free energy in nonzonal velocities and electron pressure fluctuations. At low k⊥, the electron thermal free energy is much larger than the energy in nonzonal velocities, posing a stark challenge for this model of the L-H transition.« less

  10. Concurrent effects of resource pulse amount, type, and frequency on community and population properties of consumers in detritus-based systems

    PubMed Central

    Juliano, Steven A.

    2012-01-01

    Episodic resource inputs (i.e., pulses) can affect food web properties and community dynamics, but detailed mechanistic understanding of such effects remain elusive. Natural aquatic microsystems (e.g., tree holes, human-made containers) are colonized by invertebrates that form complex food webs dependent on episodic and sometimes sizeable inputs of allochthonous detritus from adjacent terrestrial environments. We investigated how variation in pulse frequency, amount, and resource type interacted to affect richness, abundance, composition, and population sizes of colonizing invertebrates in water-filled tires and tree hole analogs in a forest habitat. Different container types were used to assess the generality of effects across two environmental contexts. Containers received large infrequent or small frequent pulses of animal or leaf detritus of different cumulative amounts distributed over the same period. Invertebrates were sampled in June and September when cumulative detritus input was equal for the two pulse frequencies. Pulse frequency and detritus type interacted to affect the responses of richness and abundance in both months; pulse frequency alone in June affected the relationship between richness and abundance. Richness and abundance were also greater with more detritus regardless of detritus type. One group, the filter feeders, were most important in driving the response of abundance and richness to pulses, especially in June. This work highlights the potential complex nature of responses of communities and populations to resource pulses and implicates the ability of certain groups to exploit pulses of detrital resources as a key to understanding community-level responses to pulses. PMID:22134863

  11. Comparison of Reconstruction Intervals in Routine ECG-Pulsed 64-Row-MSCT Coronary Angiography in Frequency Controlled Patients

    SciTech Connect

    Frydrychowicz, Alex Pache, Gregor; Saueressig, Ulrich; Foell, Daniela; Kotter, Elmar; Langer, Mathias; Bley, Thorsten A.

    2007-02-15

    Purpose. In light of the increasing use and acceptance of multislice computed tomography (MSCT) coronary angiography it was the purpose of this study to compare reconstruction intervals used in a routine ECG-pulsed MSCT coronary artery angiography setting with frequency controlled patients. Methods. Examinations were performed on a Siemens Somatom Sensation 64 scanner with a total of 110 ml of contrast agent and ECG pulsing (interval from 40% to 70%) after oral application of a {beta}-blocker if the heart rate was higher than 65 bpm. All human subjects were referred for the evaluation of suspected coronary artery disease. Coronary artery segments were evaluated by two experienced radiologists in a consensus reading. A ranking of diagnostic image quality (from 1 (no evaluation possible) to 5 (excellent image quality)) was statistically evaluated by Wilcoxon Signed Rank Test. Results. In 45 patients (30 male, 15 female, age 63.8 {+-} 12.1 years) we detected a significant advantage of the 60% reconstruction interval over 40%, 50%, and 70% (for each p < 0.05). In cases of sudden arrhythmia or movement during the scan, additional reconstruction intervals within the ECG-pulsed reconstruction intervals remained necessary for diagnosis. Conclusion. In a routine diagnostic setting with frequency controlled patients and ECG pulsing the 60% reconstruction interval can be considered superior for the initial diagnosis in 64-row multislice computed tomography coronary angiography. However, further information can be derived from various reconstruction intervals such as 40% and 70%.

  12. Simulation of high-frequency modes and their effect on insulator breakdown in the pulse line ion accelerator

    NASA Astrophysics Data System (ADS)

    Ling, C. Y.; Yu, S. S.; Henestroza, E.

    2009-07-01

    The pulse line ion accelerator (PLIA) produces a traveling electromagnetic (EM) wave by applying a voltage pulse to one end of a helix that accelerates and axially confines a heavy-ion beam pulse. An anomalous flashover phenomenon has been observed on the vacuum-insulator surface that limits the amplitude of the accelerating field. It has been suspected that a small component of high-frequency modes in the input pulse may be the cause of the breakdown. Simulation using MAFIA (MAxwell's equations by Finite Integration Algorithm) was conducted to investigate the fields on the insulator surface. A scaling law was proposed to reduce substantially the computational time in simulation. It is based on the hypothesis that the pattern of EM field for a given wavelength is independent of the wire spacing as long as the wavelength is much longer than the inter-wire spacing and the termination resistors are adjusted to maintain impedance matching. On the basis of these numerical simulations, we conclude that high-frequency modes, even at very low amplitudes, may indeed lead to the observed insulator flashover.

  13. Measurement of low-frequency magnetic pulses from negative stepped leaders in rocket-triggered lightning flashes

    NASA Astrophysics Data System (ADS)

    Lu, Gaopeng

    2017-04-01

    Measurement of low-frequency magnetic pulses from negative stepped leaders in rocket-triggered lightning flashes Gaopeng Lu,1,2 Yanfeng Fan,1,3 Hongbo Zhang,1,3 Rubin Jiang,1,2 Mingyuan Liu,1,2 and Xiushu Qie,1,2 1. Key Laboratory of Middle Atmosphere and Global Environment Observation, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing, 100029, China 2. Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters, Nanjing University of Information Science and Technology, Nanjing, Jiangsu 210044, China 3. University of Chinese Academy of Sciences, Beijing 100049, China We report the measurement of magnetic pulses from the negative stepped leaders in positive rocket-triggered lightning flashes with the low-frequency (4 kHz to 420 kHz) magnetic sensor at two different distances (78 m and 970 m, respectively) during the SHantong Artificial Triggered Lightning Experiments (SHATLE) during summer of 2015. Different from the magnetic radiation from positive leaders as observed in the considerably more frequent cases, the impulsive signals from the negative leader sustain for a much longer time interval, while the attenuation of current pulse launched by the stepping of leader is also observed. The general pattern of magnetic pulses observed for the negative stepped leader is different from the positive counterpart. Also, the initial negative leader appears to be brighter than the positive ones, as shown by both high-speed video observation and the magnetic measurement.

  14. The frequency-domain method of calculation for the pulsed electromagnetic field in a conductive ferromagnetic plate

    NASA Astrophysics Data System (ADS)

    Nosov, G. V.; Kuleshova, E. O.; Lefebvre, S.; Plyusnin, A. A.; Tokmashev, D. M.

    2017-02-01

    The technique for parameters determination of magnetic skin effect on ferromagnetic plate at a specified pulse of magnetic field intensity on the plate surface is proposed. It is based on a frequency-domain method and could be applied for a pulsing transformer, a dynamoelectric pulse generator and a commutating inductor that contains an imbricated core. Due to this technique, such plate parameters as specific heat loss energy, the average power of this energy and the plate temperature raise, the magnetic flux attenuation factor and the plate q-factor could be calculated. These parameters depend on the steel type, the amplitude, the rms value, the duration and the form of the magnetic field intensity impulse on the plate surface. The plate thickness is defined by the value of the flux attenuation factor and the plate q-factor that should be maximal. The reliability of the proposed technique is built on a common frequency-domain usage applicable for pulse transient study under zero boundary conditions of the electric circuit and the conformity of obtained results with the sinusoidal steady-state mode.

  15. Frequency-dependent changes in the paired-pulse index in the hippocampus of the freely moving adult male rat.

    PubMed

    Yorns, W R; Blaise, J H; Bronzino, J D

    2004-03-01

    The paired-pulse index (PPI) has been widely used as a measure of modulation of cellular excitability in the hippocampal trisynaptic circuit. This paper presents a quantification of the changes in this measure of neuronal modulation as a result of the application of pulse trains having six different train frequencies (0.1, 1, 5, 8, 15, and 30 Hz) to one of the major efferent pathways to the dentate gyrus, the medial perforant path (MPP). Our findings indicate that the modulation of the first leg of the hippocampal trisynaptic circuit is dependent on the frequency of the "burst train" applied to the perforant pathway. This methodological finding is of importance to all investigators studying hippocampal plasticity via LTP or LTD approaches. The different synaptic mechanisms implicated in being responsible for the changes in the PPI are also discussed.

  16. Anomalous enhancement and suppression of ionization induced by an effective few-cycle pulse in the frequency domain

    NASA Astrophysics Data System (ADS)

    Foote, David; Lin, Yingda; Hill, Wendell T., III

    2015-05-01

    In a recent set of coherent control experiments, an anomalous sinusoidal variation of the ionization yield was observed in Xe when ionized by a pairs of phase-locked, many-cycle 800 nm pulses. Compared with the signal of a single transform limited pulse, both enhancement and suppression was possible, which depended on the temporal separation and relative phase of the pulses. In the time domain, the control can be viewed as a temporal Young's double slit experiment - two coherent electron wavepackets interfering. In the frequency domain, the photoelectron spectrum is given by the modulus squared of the Fourier transform of the field, which is a few-cycle squared sinusodial function. In analogy to a few-cycle pulse where the carrier phase dictates the ejection direction of rescattered electrons, enhancement (suppression) occurs when the effective carrier waveform is cos[w-w0]2 (sin[w-w0]2). The contrast decreased with increasing pulse separation and decreasing multiphoton order. Detailed results and a model simulation will be presented.

  17. Design of radio frequency pulse waveforms for mitigating signal inhomogeneity in magnetic resonance imaging due to metallic implants

    NASA Astrophysics Data System (ADS)

    Woo, Taeseong; Kim, Dongmin; Someya, Takao; Sekino, Masaki

    2015-05-01

    Metallic implants can result in considerable inhomogeneity in the signal intensity of magnetic resonance imaging (MRI), because the implant generates a shielding effect to the applied radio-frequency (RF) magnetic fields. In this study, we propose an acquisition method to mitigate the signal inhomogeneities using an adaptive RF pulse waveform. The effectiveness of the method was investigated using both numerical simulations and experiments. The RF pulse waveform was calculated based on inverse analyses of the Bloch equation incorporating the measured RF field distribution within the object. A simulation was carried out using a simplified numerical model of RF field inhomogeneity assumed at the center of model. An RF pulse waveform was designed to recover the attenuated signal region in the given model, and we show a significant improvement in the signal homogeneity compared with that obtained using a conventional pulse. We implemented the proposed method on a 7T-MRI system to show the efficacy experimentally. Test samples were fabricated from agarose gel with inserted copper or aluminum implants of different thicknesses. The RF pulse for selective excitation was calculated after mapping the RF field distribution of each imaging object. The acquired images exhibit an improvement in the homogeneity at the region of metallic implants. These results indicate that the proposed method is effective for MRI measurements of objects containing metallic implants.

  18. Growth of high spatial frequency periodic ripple structures on SiC crystal surfaces irradiated with successive femtosecond laser pulses.

    PubMed

    Obara, Go; Shimizu, Hisashi; Enami, Taira; Mazur, Eric; Terakawa, Mitsuhiro; Obara, Minoru

    2013-11-04

    We present experimentally and theoretically the evolution of high spatial frequency periodic ripples (HSFL) fabricated on SiC crystal surfaces by irradiation with femtosecond laser pulses in a vacuum chamber. At early stages the seed defects are mainly induced by laser pulse irradiation, leading to the reduction in the ablation threshold fluence. By observing the evolution of these surface structures under illumination with successive laser pulses, the nanocraters are made by nanoablation at defects in the SiC surface. The Mie scattering by the nanoablated craters grows the periodic ripples. The number of HSFL is enhanced with increasing pulse number. At the edge of the laser spot the Mie scattering process is still dominant, causing the fabrication of HSFL. On the periphery of the spot SiC substrate remains a semiconductor state because the electron density in the SiC induced by laser irradiation is kept low. The HSFL observed is very deep in the SiC surface by irradiating with many laser pulses. These experimental results are well explained by 3D FDTD (three-dimensional finite-difference time-domain) simulation.

  19. Soft-Decision-Data Reshuffle to Mitigate Pulsed Radio Frequency Interference Impact on Low-Density-Parity-Check Code Performance

    NASA Technical Reports Server (NTRS)

    Ni, Jianjun David

    2011-01-01

    This presentation briefly discusses a research effort on mitigation techniques of pulsed radio frequency interference (RFI) on a Low-Density-Parity-Check (LDPC) code. This problem is of considerable interest in the context of providing reliable communications to the space vehicle which might suffer severe degradation due to pulsed RFI sources such as large radars. The LDPC code is one of modern forward-error-correction (FEC) codes which have the decoding performance to approach the Shannon Limit. The LDPC code studied here is the AR4JA (2048, 1024) code recommended by the Consultative Committee for Space Data Systems (CCSDS) and it has been chosen for some spacecraft design. Even though this code is designed as a powerful FEC code in the additive white Gaussian noise channel, simulation data and test results show that the performance of this LDPC decoder is severely degraded when exposed to the pulsed RFI specified in the spacecraft s transponder specifications. An analysis work (through modeling and simulation) has been conducted to evaluate the impact of the pulsed RFI and a few implemental techniques have been investigated to mitigate the pulsed RFI impact by reshuffling the soft-decision-data available at the input of the LDPC decoder. The simulation results show that the LDPC decoding performance of codeword error rate (CWER) under pulsed RFI can be improved up to four orders of magnitude through a simple soft-decision-data reshuffle scheme. This study reveals that an error floor of LDPC decoding performance appears around CWER=1E-4 when the proposed technique is applied to mitigate the pulsed RFI impact. The mechanism causing this error floor remains unknown, further investigation is necessary.

  20. Grism-based pulse shaper for line-by-line control of more than 600 optical frequency comb lines.

    PubMed

    Kirchner, M S; Diddams, S A

    2010-10-01

    We construct a line-by-line pulse shaper using a grism (grating plus prism) dispersive element, which provides constant angular dispersion over 13.4 THz centered at ~311 THz (965 nm). When combined with a dual-mask liquid crystal modulator, this grism-based shaper is capable of line-by-line amplitude and phase control of over 600 modes of a 21 GHz stabilized optical frequency comb.

  1. Low-frequency pulsed electromagnetic fields significantly improve time of closure and proliferation of human tendon fibroblasts

    PubMed Central

    2014-01-01

    Background The promotion of the healing process following musculoskeletal injuries comprises growth factor signalling, migration, proliferation and apoptosis of cells. If these processes could be modulated, the healing of tendon tissue may be markedly enhanced. Here, we report the use of the Somagen™ device, which is certified for medical use according to European laws. It generates low-frequency pulsed electromagnetic fields that trigger effects of a nature that are yet to be determined. Methods A 1.5-cm wide, linear scrape was introduced into patellar tendon fibroblast cultures (N = 5 donors). Treatment was carried out every second day. The regimen was applied three times in total with 30 minutes comprising pulsed electromagnetic field packages with two fundamental frequencies (10 minutes of 33 Hz, 20 minutes of 7.8 Hz). Control cells remained untreated. All samples were analyzed for gap closure time, proliferation and apoptosis one week after induction of the scrape wound. Results The mean time for bridging the gap in the nontreated cells was 5.05 ± 0.33 days, and in treated cells, it took 3.35 ± 0.38 days (P <0.001). For cell cultures with scrape wounds, a mean value for BrdU incorporation of OD = 0.70 ± 0.16 was found. Whereas low-frequency pulsed electromagnetic fields treated samples showed OD = 1.58 ± 0.24 (P <0.001). However, the percentage of apoptotic cells did not differ between the two groups. Conclusions Our data demonstrate that low-frequency pulsed electromagnetic fields emitted by the Somagen™ device influences the in vitro wound healing of patellar tendon fibroblasts and, therefore, possibly increases wound healing potential. PMID:24996421

  2. Low-frequency pulsed electromagnetic fields significantly improve time of closure and proliferation of human tendon fibroblasts.

    PubMed

    Seeliger, Claudine; Falldorf, Karsten; Sachtleben, Jens; van Griensven, Martijn

    2014-07-05

    The promotion of the healing process following musculoskeletal injuries comprises growth factor signalling, migration, proliferation and apoptosis of cells. If these processes could be modulated, the healing of tendon tissue may be markedly enhanced. Here, we report the use of the Somagen™ device, which is certified for medical use according to European laws. It generates low-frequency pulsed electromagnetic fields that trigger effects of a nature that are yet to be determined. A 1.5-cm wide, linear scrape was introduced into patellar tendon fibroblast cultures (N = 5 donors). Treatment was carried out every second day. The regimen was applied three times in total with 30 minutes comprising pulsed electromagnetic field packages with two fundamental frequencies (10 minutes of 33 Hz, 20 minutes of 7.8 Hz). Control cells remained untreated. All samples were analyzed for gap closure time, proliferation and apoptosis one week after induction of the scrape wound. The mean time for bridging the gap in the nontreated cells was 5.05 ± 0.33 days, and in treated cells, it took 3.35 ± 0.38 days (P <0.001). For cell cultures with scrape wounds, a mean value for BrdU incorporation of OD = 0.70 ± 0.16 was found. Whereas low-frequency pulsed electromagnetic fields treated samples showed OD = 1.58 ± 0.24 (P <0.001). However, the percentage of apoptotic cells did not differ between the two groups. Our data demonstrate that low-frequency pulsed electromagnetic fields emitted by the Somagen™ device influences the in vitro wound healing of patellar tendon fibroblasts and, therefore, possibly increases wound healing potential.

  3. Three-dimensional time and frequency-domain theory of femtosecond x-ray pulse generation through Thomson Scattering

    SciTech Connect

    Brown, W J; Hartemann, F V

    2004-01-27

    The generation of high intensity, ultra-short x-ray pulses enables exciting new experimental capabilities, such as femtosecond pump-probe experiments used to temporally resolve material structural dynamics on atomic time scales. Thomson backscattering of a high intensity laser pulse with a bright relativistic electron bunch is a promising method for producing such high brightness x-ray pulses in the 10-100 keV range within a compact facility. While a variety of methods for producing sub-picosecond x-ray bursts by Thomson scattering exist, including compression of the electron bunch to sub-picosecond bunch lengths and/or colliding a sub-picosecond laser pulse in a side-on geometry to minimize the interaction time, a promising alternative approach to achieving this goal while maintaining ultra-high brightness is the production of a time correlated (or chirped) x-ray pulse in conjunction with pulse slicing or compression. We present the results of a complete analysis of this process using a recently developed 3-D time and frequency-domain code for analyzing the spatial, temporal, and spectral properties an x-ray beam produced by relativistic Thomson scattering. Based on the relativistic differential cross section, this code has the capability to calculate time and space dependent spectra of the x-ray photons produced from linear Thomson scattering for both bandwidth-limited and chirped incident laser pulses. Spectral broadening of the scattered x-ray pulse resulting from the incident laser bandwidth, laser focus, and the transverse and longitudinal phase space of the electron beam were examined. Simulations of chirped x-ray pulse production using both a chirped electron beam and a chirped laser pulse are presented. Required electron beam and laser parameters are summarized by investigating the effects of beam emittance, energy spread, and laser bandwidth on the scattered x-ray spectrum. It is shown that sufficient temporal correlation in the scattered x-ray spectrum

  4. Plasma channel produced by femtosecond laser pulses as a medium for amplifying electromagnetic radiation of the subterahertz frequency range

    SciTech Connect

    Bogatskaya, A V; Volkova, E A; Popov, A M

    2013-12-31

    The electron energy distribution function in the plasma channel produced by a femtosecond laser pulse with a wavelength of 248 nm in atmospheric-pressure gases was considered. Conditions were determined whereby this channel may be employed for amplifying electromagnetic waves up to the terahertz frequency range over the energy spectrum relaxation time ∼10{sup -7} s. Gains were calculated as functions of time and radiation frequency. The effect of electron – electron collisions on the rate of relaxation processes in the plasma and on its ability to amplify the electromagnetic radiation was investigated. (interaction of laser radiation with matter)

  5. OPO performance with a long pulse length, single frequency Nd:YAG laser pump. [Optical Parametric Oscillators

    NASA Technical Reports Server (NTRS)

    Kozlovsky, W. J.; Gustafson, E. K.; Eckardt, R. C.; Byer, R. L.

    1988-01-01

    With the advent of new nonlinear materials and single-frequency pump sources, there is renewed interest in optical parametric oscillators (OPOs). A single-mode diode-laser-pumped monolithic Nd:YAG nonplanar ring laser that is both amplified and frequency doubled is used to pump a monolithic MgO:LiNbO3 pulsed singly resonant OPO. The OPO signal output was temperature tuned from 834 to 958 nm, producing an idler tuning from 1.47 to 1.2 microns. Efforts toward a CW all-solid-state doubly resonant OPO are also described.

  6. OPO performance with a long pulse length, single frequency Nd:YAG laser pump. [Optical Parametric Oscillators

    NASA Technical Reports Server (NTRS)

    Kozlovsky, W. J.; Gustafson, E. K.; Eckardt, R. C.; Byer, R. L.

    1988-01-01

    With the advent of new nonlinear materials and single-frequency pump sources, there is renewed interest in optical parametric oscillators (OPOs). A single-mode diode-laser-pumped monolithic Nd:YAG nonplanar ring laser that is both amplified and frequency doubled is used to pump a monolithic MgO:LiNbO3 pulsed singly resonant OPO. The OPO signal output was temperature tuned from 834 to 958 nm, producing an idler tuning from 1.47 to 1.2 microns. Efforts toward a CW all-solid-state doubly resonant OPO are also described.

  7. Dynamic assessment of spontaneous baroreflex sensitivity by means of time-frequency analysis using either RR or pulse interval variability.

    PubMed

    Orini, Michele; Mainardi, Luca T; Gil, Eduardo; Laguna, Pablo; Bailon, Raquel

    2010-01-01

    In this study we propose a method to continuously assess the changes of spontaneous baroreflex sensitivity (BRS). Systolic arterial pressure and RR intervals are analyzed by time-frequency analysis to estimate their instantaneous powers as well as the time-course of their spectral coherence. The BRS estimated in classical frequency bands is compared to the BRS estimated in dynamic frequency bands centered on respiratory frequency. The possibility of obtaining reliable estimations of the BRS using the pulse interval from the pressure signal as a surrogate of the RR is considered. Results on a tilt table test database suggest that is possible to obtain reliable BRS estimates just from the analysis of the pressure signal, without the need of ECG recordings.

  8. Effect of the stimulus frequency and pulse number of repetitive transcranial magnetic stimulation on the inter-reversal time of perceptual reversal on the right superior parietal lobule

    NASA Astrophysics Data System (ADS)

    Nojima, Kazuhisa; Ge, Sheng; Katayama, Yoshinori; Ueno, Shoogo; Iramina, Keiji

    2010-05-01

    The aim of this study is to investigate the effect of the stimulus frequency and pulses number of repetitive transcranial magnetic stimulation (rTMS) on the inter-reversal time (IRT) of perceptual reversal on the right superior parietal lobule (SPL). The spinning wheel illusion was used as the ambiguous figures stimulation in this study. To investigate the rTMS effect over the right SPL during perceptual reversal, 0.25 Hz 60 pulse, 1 Hz 60 pulse, 0.5 Hz 120 pulse, 1 Hz 120 pulse, and 1 Hz 240 pulse biphasic rTMS at 90% of resting motor threshold was applied over the right SPL and the right posterior temporal lobe (PTL), respectively. As a control, a no TMS was also conducted. It was found that rTMS on 0.25 Hz 60 pulse and 1 Hz 60 pulse applied over the right SPL caused shorter IRT. In contrast, it was found that rTMS on 1 Hz 240-pulse applied over the right SPL caused longer IRT. On the other hand, there is no significant difference between IRTs when the rTMS on 0.5 Hz 120 pulse and 1 Hz 120 pulse were applied over the right SPL. Therefore, the applying of rTMS over the right SPL suggests that the IRT of perceptual reversal is effected by the rTMS conditions such as the stimulus frequency and the number of pulses.

  9. Frequency entanglement characterization of short-pulse pumped SPDC biphoton source with a Mach-Zehnder interferometer

    NASA Astrophysics Data System (ADS)

    Zhai, Yiwei; Dong, Ruifang; Li, Baihong; Quan, Runai; Wang, Mengmeng; Hou, Feiyan; Liu, Tao; Zhang, Shougang

    2017-06-01

    Frequency entangled biphoton sources have played an important role in quantum information. There are two key characteristics which determine the extent of their applications: the spectral indistinguishability and the degree of frequency entanglement. Previously, the spectral indistinguishability of the biphoton state is measured by the Hong-Ou-Mandel (HOM) interference visibility, whereas the degree of frequency entanglement is normally characterized with independent spectral measurements. However, these two quantum features have not been successfully measured with a single experimental setup. In this paper, we deduce the temporal distribution of a short-pulse pumped type-II spontaneous parametric down converted (SPDC) biphoton source and its relevant temporal entanglement parameter R t for operationally quantifying the degree of frequency entanglement. Furthermore, we theoretically and experimentally demonstrate, due to the inherent group delay, the difference between the signal and idler photons at the exit of the type-II nonlinear crystal, resulting in a HOM-shape dip at both sides of the center fringed envelope of the MZ interferometric coincidence diagram. By measuring the HOM-shape dip depth, the separation between the two sideband dips as well as the MZ fringed envelope width, both the spectral indistinguishability and the temporal entanglement parameter can thus be simultaneously quantified. This implementation provides us a unified and convenient method to characterize the frequency entanglement of the short-pulse pumped biphotons.

  10. Hairpin resonator probes with frequency domain boxcar operation for time resolved density measurements in pulsed RF discharges

    NASA Astrophysics Data System (ADS)

    Peterson, David; Kummerer, Theresa; Coumou, David; Shannon, Steven

    2014-10-01

    In this work, microsecond time resolved electron density measurements in pulsed RF discharges are shown using an automated hairpin resonance probe using relatively low cost electronics, on par with normal Langmuir probe boxcar mode operation. A low cost signal generator is used to produce the applied microwave frequency and the reflected waveform is filtered to remove the RF component. The signal is then heterodyned with a simple frequency mixer to produce a dc signal read by an oscilloscope to determine the electron density. The applied microwave frequency is automatically shifted in small increments in a frequency boxcar routine through a Labview™program to determine the resonant frequency. A simple dc sheath correction is then easily applied since the probe is fully floating, producing low cost, high fidelity, and highly reproducible electron density measurements. The measurements are made in a capacitively coupled, parallel plate configuration in a 13.56 MHz, 50--200 W RF discharge pulsed at 500 Hz, 200 W, 50% duty cycle. The gas input ranged from 50--100 mTorr pure Ar or with 5--10% O/He mixtures.

  11. Spectral comb of highly chirped pulses generated via cascaded FWM of two frequency-shifted dissipative solitons.

    PubMed

    Podivilov, Evgeniy V; Kharenko, Denis S; Bednyakova, Anastasia E; Fedoruk, Mikhail P; Babin, Sergey A

    2017-06-06

    Dissipative solitons generated in normal-dispersion mode-locked lasers are stable localized coherent structures with a mostly linear frequency modulation (chirp). The soliton energy in fiber lasers is limited by the Raman effect, but implementation of the intracavity feedback at the Stokes-shifted wavelength enables synchronous generation of a coherent Raman dissipative soliton. Here we demonstrate a new approach for generating chirped pulses at new wavelengths by mixing in a highly-nonlinear fiber of these two frequency-shifted dissipative solitons, as well as cascaded generation of their clones forming in the spectral domain a comb of highly chirped pulses. We observed up to eight equidistant components in the interval of more than 300 nm, which demonstrate compressibility from ~10 ps to ~300 fs. This approach, being different from traditional frequency combs, can inspire new developments in fundamental science and applications such as few-cycle/arbitrary-waveform pulse synthesis, comb spectroscopy, coherent communications and bio-imaging.

  12. Efficiency of non-linear frequency conversion of double-scale pico-femtosecond pulses of passively mode-locked fiber laser.

    PubMed

    Smirnov, Sergey V; Kobtsev, Sergey M; Kukarin, Sergey V

    2014-01-13

    For the first time we report the results of both numerical simulation and experimental observation of second-harmonic generation as an example of non-linear frequency conversion of pulses generated by passively mode-locked fiber master oscillator in different regimes including conventional (stable) and double-scale (partially coherent and noise-like) ones. We show that non-linear frequency conversion efficiency of double-scale pulses is slightly higher than that of conventional picosecond laser pulses with the same energy and duration despite strong phase fluctuations of double-scale pulses.

  13. Frequency divide-and-conquer approach to producing octave-wide frequency combs and few-cycle pulses in the mid-IR

    NASA Astrophysics Data System (ADS)

    Vodopyanov, Konstantin

    2014-05-01

    I will present a new technique for extending frequency combs to the highly desirable yet difficult-to-achieve mid-IR spectral range. The technique is based on subharmonic optical parametric oscillation (OPO) that can be considered as a reverse of the second harmonic generation process. The frequency comb of a pump laser is transposed to half of its central frequency and simultaneously spectrally augmented, thanks to an enormous gain bandwidth of the OPO near degeneracy, as well as due to massive cross-coupling between the laser and the OPO frequency comb components. Using ultrafast erbium (1.56 microns) or thulium (2 microns)-based fiber lasers as a pump and using thin, sub-mm-long, quasi phase-matched lithium niobate or gallium arsenide crystals, we produce frequency combs centered correspondingly at 3.1 or 4 micron subharmonic of the pump frequency. With the properly managed OPO cavity group velocity dispersion, octave-wide frequency combs spanning 2.5 - 6 micron range were achieved. Due to the doubly-resonant operation, the threshold of such a system is low (typically 10 mW) and by several experiments including measuring frequency beats between the OPO comb teeth and a narrow-linewidth CW laser and by interfering the outputs of two identical but distinct OPOs pumped by the same laser, we established that the frequency comb from a subharmonic OPO is phase-locked to that of the pump laser. Pulse duration measurements show that for the optimal intracavity dispersion conditions, we generate sub 5-cycle pulses at the subharmonic of the pump. I will also talk about applications of our mid-IR frequency combs to trace gas detection, where part-per-billion sensitivity of molecular detection is achieved as well as about Fourier spectroscopy using a dual-comb system consisting of two phase-locked lasers. I thank NASA, Office of Naval Research, Air Force Office of Scientific Research, Agilent Technologies, Sanofi- Aventis, Stanford University Bio-X, Stanford Medical School

  14. Robust integral variable structure controller and pulse-width pulse-frequency modulated input shaper design for flexible spacecraft with mismatched uncertainty/disturbance.

    PubMed

    Hu, Qinglei

    2007-10-01

    This paper presents a dual-stage control system design method for the flexible spacecraft attitude maneuvering control by use of on-off thrusters and active vibration control by input shaper. In this design approach, attitude control system and vibration suppression were designed separately using lower order model. As a stepping stone, an integral variable structure controller with the assumption of knowing the upper bounds of the mismatched lumped perturbation has been designed which ensures exponential convergence of attitude angle and angular velocity in the presence of bounded uncertainty/disturbances. To reconstruct estimates of the system states for use in a full information variable structure control law, an asymptotic variable structure observer is also employed. In addition, the thruster output is modulated in pulse-width pulse-frequency so that the output profile is similar to the continuous control histories. For actively suppressing the induced vibration, the input shaping technique is used to modify the existing command so that less vibration will be caused by the command itself, which only requires information about the vibration frequency and damping of the closed-loop system. The rationale behind this hybrid control scheme is that the integral variable structure controller can achieve good precision pointing, even in the presence of uncertainties/disturbances, whereas the shaped input attenuator is applied to actively suppress the undesirable vibrations excited by the rapid maneuvers. Simulation results for the spacecraft model show precise attitude control and vibration suppression.

  15. Influence of driving frequency on discharge modes in a dielectric-barrier discharge with multiple current pulses

    SciTech Connect

    Jiang, Weiman; Tang, Jie; Wang, Yishan; Zhao, Wei; Duan, Yixiang

    2013-07-15

    A one-dimensional self-consistent fluid model was employed to investigate the effect of the driving frequency on the discharge modes in atmospheric-pressure argon discharge with multiple current pulses. The discharge mode was discussed in detail not only at current peaks but also between two adjacent peaks. The simulation results show that different transitions between the Townsend and glow modes during the discharge take place with the driving frequency increased. A complicated transition from the Townsend mode, through glow, Townsend, and glow, and finally back to the Townsend one is found in the discharge with the driving frequency of 8 kHz. There is a tendency of transition from the Townsend to glow mode for the discharge both at the current peaks and troughs with the increasing frequency. The discharge in the half period can all along operate in the glow mode with the driving frequency high enough. This is resulted from the preservation of more electrons in the gas gap and acquisition of more electron energy from the swiftly varying electric field with the increase in driving frequency. Comparison of the spatial and temporal evolutions of the electron density at different driving frequencies indicates that the increment of the driving frequency allows the plasma chemistry to be enhanced. This electrical characteristic is important for the applications, such as surface treatment and biomedical sterilization.

  16. X-ray Spectra and Pulse Frequency Changes in SAX J2103.5+4545

    NASA Technical Reports Server (NTRS)

    Baykal, A.; Stark, M. J.; Swank, J. H.; White, Nicholas E. (Technical Monitor)

    2002-01-01

    The November 1999 outburst of the transient pulsar SAX J2103.5+4545 was monitored with the large area detectors of the Rossi X-Ray Timing Explorer until the pulsar faded after a year. The 358 s pulsar was spun up for 150 days, at which point the flux dropped quickly by a factor of approximately 7, the frequency saturated and, as the flux continued to decline, a weak spin-down began. The pulses remained strong during the decay and the spin-up/flux correlation can be fit to the Ghosh and Lamb derivations for the spin-up caused by accretion from a thin, pressure-dominated disk, for a distance approximately 3.2 kpc and a surface magnetic field approximately 1.2 x 10(exp 13) Gauss. During the bright spin-up part of the outburst, the flux was subject to strong orbital modulation, peaking approximately 3 days after periastron of the eccentric 12.68 day orbit, while during the faint part, there was little orbital modulation. The X-ray spectra were typical of accreting pulsars, describable by a cut-off power-law, with an emission line near the 6.4 keV of Kappa(sub alpha) fluorescence from cool iron. The equivalent width of this emission did not share the orbital modulation, but nearly doubled during the faint phase, despite little change in the column density. The outburst could have been caused by an episode of increased wind from a Be star, such that a small accretion disk is formed during each periastron passage. A change in the wind and disk structure apparently occurred after 5 months such that the accretion rate was no longer modulated or the diffusion time was longer. The distance estimate implies the X-ray luminosity observed was between 1 X 10(exp 36) ergs s(exp -1) and 6 x 10(exp 34) ergs s(exp -1), with a small but definite correlation of the intrinsic power-law spectral index.

  17. Phonotactic selectivity in two cryptic species of gray treefrogs: effects of differences in pulse-rate, carrier frequency, and playback level

    PubMed Central

    Gerhardt, H. Carl

    2008-01-01

    Summary The two main spectral components of the advertisement calls of two species of North American gray treefrogs (Hyla chrysoscelis and H. versicolor) overlap broadly in frequency, and each matches the sensitivity of one of the two different auditory inner ear organs. The calls of the two species differ in the shape and repetition-rate (pulse rate) of sound pulses within trills. A standard synthetic call with one of these spectral peaks and the pulse rate typical of conspecific calls was tested against synthetic alternatives that had the same spectral peak but a different pulse rate. The results were generalized over a wide range of playback levels. Selectivity based on differences in pulse rate depended on which spectral peak was used in some tests, and greater pulse-rate selectivity was usually observed when the low-frequency rather than the high-frequency peak was used. This effect was more pronounced and occurred over a wider range of playback levels in H. versicolor than in H. chrysoscelis when the pulse rate of the alternative was higher than that of the standard call. In tests using the high-frequency peak at high playback levels, however, females of H. versicolor showed greater selectivity for the standard call than did H. chrysoscelis when the pulse rate of the alternative was modestly lower than that of the standard call. This last result may reflect the different ways in which females of the two species assess trains of pulses. PMID:18689414

  18. Transient Response of Arc Temperature and Iron Vapor Concentration Affected by Current Frequency with Iron Vapor in Pulsed Arc

    NASA Astrophysics Data System (ADS)

    Tanaka, Tatsuro; Maeda, Yoshifumi; Yamamoto, Shinji; Iwao, Toru

    2016-10-01

    TIG arc welding is chemically a joining technology with melting the metallic material and it can be high quality. However, this welding should not be used in high current to prevent cathode melting. Thus, the heat transfer is poor. Therefore, the deep penetration cannot be obtained and the weld defect sometimes occurs. The pulsed arc welding has been used for the improvement of this defect. The pulsed arc welding can control the heat flux to anode. The convention and driving force in the weld pool are caused by the arc. Therefore, it is important to grasp the distribution of arc temperature. The metal vapor generate from the anode in welding. In addition, the pulsed current increased or decreased periodically. Therefore, the arc is affected by such as a current value and current frequency, the current rate of increment and the metal vapor. In this paper, the transient response of arc temperature and the iron vapor concentration affected by the current frequency with iron vapor in pulsed arc was elucidated by the EMTF (ElectroMagnetic Thermal Fluid) simulation. As a result, the arc temperature and the iron vapor were transient response as the current frequency increase. Thus, the temperature and the electrical conductivity decreased. Therefore, the electrical field increased in order to maintain the current continuity. The current density and electromagnetic force increased at the axial center. In addition, the electronic flow component of the heat flux increased at the axial center because the current density increased. However, the heat conduction component of the heat flux decreased.

  19. Effect of pulse frequency on microstructural, nanomechanical, and wear properties of electrodeposited Ni-TiN composite coatings

    NASA Astrophysics Data System (ADS)

    Xia, Fafeng; Tian, Jiyu; Ma, Chunyang; Potts, Matt; Guo, Xue

    2014-12-01

    The current paper reports successful syntheses of Ni-TiN composite coatings by pulse electrodeposition. The effect of pulse frequency on the microstructures, nanomechanical, and wear properties of the coatings was investigated using transmission electron microscopy, X-ray diffraction, nanoindenter, scanning electron microscopy, and wear test instrument. The results showed that the Ni-TiN composite coating prepared at the pulse frequency of 100 Hz showed the presence of a less number of TiN particles and some degrees of aggregation in micro-regions. By contrast, in the Ni-TiN coating deposited at the pulse frequency of 500 Hz, the TiN particles were large in number and dispersed homogeneously, thereby, offering the coating a uniform and fine structure. The average grain diameters of Ni and TiN in the coating prepared at 100 Hz were 154.7 and 44.8 nm, respectively, whereas those for the coating prepared at 500 Hz were 67.3 and 25.9 nm, respectively. The maximum TiN content in the Ni-TiN coating deposited at 800 Hz was approximately 10.5 wt. %. The maximum microhardness and the Young's modulus values for the Ni-TiN composite coatings deposited at 800 Hz were 35.7 GPa and 167.4 GPa, respectively. Furthermore, the Ni-TiN composite coating prepared at 100 Hz had more severe damages, whereas the morphologies of worn surface of the coatings deposited at 500 Hz and 800 Hz were smooth and only a few small pits appeared on the surface.

  20. Effect of pulse frequency on microstructural, nanomechanical, and wear properties of electrodeposited Ni–TiN composite coatings

    SciTech Connect

    Xia, Fafeng; Tian, Jiyu; Ma, Chunyang Guo, Xue; Potts, Matt

    2014-12-21

    The current paper reports successful syntheses of Ni–TiN composite coatings by pulse electrodeposition. The effect of pulse frequency on the microstructures, nanomechanical, and wear properties of the coatings was investigated using transmission electron microscopy, X–ray diffraction, nanoindenter, scanning electron microscopy, and wear test instrument. The results showed that the Ni–TiN composite coating prepared at the pulse frequency of 100 Hz showed the presence of a less number of TiN particles and some degrees of aggregation in micro-regions. By contrast, in the Ni–TiN coating deposited at the pulse frequency of 500 Hz, the TiN particles were large in number and dispersed homogeneously, thereby, offering the coating a uniform and fine structure. The average grain diameters of Ni and TiN in the coating prepared at 100 Hz were 154.7 and 44.8 nm, respectively, whereas those for the coating prepared at 500 Hz were 67.3 and 25.9 nm, respectively. The maximum TiN content in the Ni-TiN coating deposited at 800 Hz was approximately 10.5 wt. %. The maximum microhardness and the Young's modulus values for the Ni–TiN composite coatings deposited at 800 Hz were 35.7 GPa and 167.4 GPa, respectively. Furthermore, the Ni–TiN composite coating prepared at 100 Hz had more severe damages, whereas the morphologies of worn surface of the coatings deposited at 500 Hz and 800 Hz were smooth and only a few small pits appeared on the surface.

  1. Spontaneous and mitomycin-C-induced micronuclei in human lymphocytes exposed to extremely low frequency pulsed magnetic fields

    SciTech Connect

    Scarfi, M.R.; Bersani, F.; Cossarizza, A.; Monti, D.; Castellani, G.; Cadossi, R.; Franceschetti, G.; Franceschi, C. )

    1991-04-15

    The cytokinesis block micronucleus method, a very sensitive cytogenetic assay, was used to ascertain the possible genotoxic effects of extremely low frequency pulsed magnetic fields in phytohemagglutinin-stimulated human lymphocytes cultures from 16 healthy donors. Four conditions were studied: lymphocytes not exposed to the field (control cultures); lymphocytes exposed to the field; lymphocytes treated with mitomycin-C and not exposed to the field; and lymphocytes treated with mitomycin-C and exposed to the field. Mitomycin-C-treated cultures were used as control for the micronucleus method, because it is known that mitomycin-C is a potent genotoxic agent, capable of inducing micronuclei. The frequency of micronuclei in field-exposed cultures was similar to the spontaneous frequency observed in control unexposed-cultures. Moreover, the exposure to pulsed magnetic fields did not affect the frequency of micronuclei induced by mitomycin-C, suggesting that, in the experimental conditions used, this kind of field neither affected the integrity of chromosomes nor interfered with the genotoxic activity of mitomycin-C.

  2. Maternal postpartum learned helplessness (LH) affects maternal care by dams and responses to the LH test in adolescent offspring.

    PubMed

    Kurata, Akiko; Morinobu, Shigeru; Fuchikami, Manabu; Yamamoto, Shigeto; Yamawaki, Shigeto

    2009-06-01

    It is known that the early environment affects the mental development of rodent and human offspring. However, it is not known specifically whether a postpartum depressive state influences the depressive state in offspring. Using learned helplessness (LH) in rats as an animal model of depression, we examined the influence of maternal postpartum LH on responses to the LH test of offspring. Dam rats were judged as LH or non-helpless (nLH) on postnatal days (PN) 2-3, and maternal behavior was recorded during PN2-14. On PN 45-46, offspring were subjected to the LH test. Plasma corticosterone (CORT) levels, hippocampal levels of glucocorticoid receptor (GR) and brain-derived neurotrophic factor (BDNF) mRNA were measured before and after the LH test in offspring. Active nursing in LH dams was significantly lower than that in nLH dams. Susceptibility to LH in the offspring of LH dams was significantly higher than in those of nLH dams, and was negatively correlated with active nursing by LH dams. The GR mRNA levels before and after the LH test were lower in the offspring of LH dams than in those of nLH dams, and the reduced basal GR mRNA and protein might have resulted in the higher CORT response after the LH test. There was no significant difference in BDNF mRNA in the offspring of LH and nLH dams. These findings suggest that early postpartum LH decreased active nursing and increased depression-like behavior in the adolescent offspring via dysfunction of the hypothalamic-pituitary-adrenal axis.

  3. An optical coherent transient true-time delay device: Concept development and experimental demonstrations including delay programming with frequency-chirped pulses

    NASA Astrophysics Data System (ADS)

    Merkel, Kristian Doyle

    1998-09-01

    A coherent transient true-time delay regenerator is presented in terms of conceptual development, simulations and experimental demonstrations in Tm3+:YAG. Theory predicts the arrival time of the emitted signals for a three-pulse sequence of square pulses. A shifting of the emitted signal's arrival time as a function of the individual pulse's area and duration is experimentally demonstrated. A novel delay-programming scheme is presented using linear frequency-chirped pulses. This technique enables changing the programmed delay only by frequency-shifting one (or both) of these pulses without changing its timing, bandwidth or duration. A delay range of 500 ns with sub-100 ps resolution is demonstrated for a signal bandwidth of 40 MHz. A continuous data stream of 100 bits, of a duration longer than the dephasing time T2 of Tm3+:YAG, is also delayed by a grating stored with linear frequency-chirped pulses. Frequency division multiplexing of delays is experimentally demonstrated for two delays whose gratings are in adjacent frequency channels, and stored with linear frequency-chirped pulses. The application of a coherent transient true-time delay device in array antennas is considered, and future research directions for this implementation are given.

  4. Numerical solution to the Bloch equations: paramagnetic solutions under wideband continuous radio frequency irradiation in a pulsed magnetic field

    NASA Astrophysics Data System (ADS)

    Chen, Wen-Jun; Ma, Hong; Yu, De; Zeng, Xiao-Hu

    2016-08-01

    A novel nuclear magnetic resonance (NMR) experimental scheme, called wideband continuous wave NMR (WB-CW-NMR), is presented in this article. This experimental scheme has promising applications in pulsed magnetic fields, and can dramatically improve the utilization of the pulsed field. The feasibility of WB-CW-NMR scheme is verified by numerically solving modified Bloch equations. In the numerical simulation, the applied magnetic field is a pulsed magnetic field up to 80 T, and the wideband continuous radio frequency (RF) excitation is a band-limited (0.68-3.40 GHz) white noise. Furthermore, the influences of some experimental parameters, such as relaxation time, applied magnetic field strength and wideband continuous RF power, on the WB-CW-NMR signal are analyzed briefly. Finally, a multi-channel system framework for transmitting and receiving ultra wideband signals is proposed, and the basic requirements of this experimental system are discussed. Meanwhile, the amplitude of the NMR signal, the level of noise and RF interference in WB-CW-NMR experiments are estimated, and a preliminary adaptive cancellation plan is given for detecting WB-CW-NMR signal from large background interference. Supported by National Natural Science Foundation of China (11475067), the Innovative Research Foundation of Huazhong University of Science and Technology (2015 ZDTD017) and the Experimental Apparatus Research Project of Wuhan Pulsed High Magnetic Field Center (2015KF17)

  5. Time- and frequency-resolved coherent anti-Stokes Raman scattering spectroscopy with sub-25 fs laser pulses

    NASA Astrophysics Data System (ADS)

    Lausten, Rune; Smirnova, Olga; Sussman, Benjamin J.; Gräfe, Stefanie; Mouritzen, Anders S.; Stolow, Albert

    2008-06-01

    In general, many different diagrams can contribute to the signal measured in broadband four-wave mixing experiments. Care must therefore be taken when designing an experiment to be sensitive to only the desired diagram by taking advantage of phase matching, pulse timing, sequence, and the wavelengths employed. We use sub-25 fs pulses to create and monitor vibrational wavepackets in gaseous iodine, bromine, and iodine bromide through time- and frequency-resolved femtosecond coherent anti-Stokes Raman scattering (CARS) spectroscopy. We experimentally illustrate this using iodine, where the broad bandwidths of our pulses, and Boltzmann population in the lower three vibrational levels conspire to make a single diagram dominant in one spectral region of the signal spectrum. In another spectral region, however, the signal is the sum of two almost equally contributing diagrams, making it difficult to directly extract information about the molecular dynamics. We derive simple analytical expressions for the time- and frequency-resolved CARS signal to study the interplay of different diagrams. Expressions are given for all five diagrams which can contribute to the CARS signal in our case.

  6. An analysis of short pulse and dual frequency radar techniques for measuring ocean wave spectra from satellites

    NASA Technical Reports Server (NTRS)

    Jackson, F. C.

    1980-01-01

    Scanning beam microwave radars were used to measure ocean wave directional spectra from satellites. In principle, surface wave spectral resolution in wave number can be obtained using either short pulse (SP) or dual frequency (DF) techniques; in either case, directional resolution obtains naturally as a consequence of a Bragg-like wave front matching. A four frequency moment characterization of backscatter from the near vertical using physical optics in the high frequency limit was applied to an analysis of the SP and DF measurement techniques. The intrinsic electromagnetic modulation spectrum was to the first order in wave steepness proportional to the large wave directional slope spectrum. Harmonic distortion was small and was a minimum near 10 deg incidence. NonGaussian wave statistics can have an effect comparable to that in the second order of scattering from a normally distributed sea surface. The SP technique is superior to the DF technique in terms of measurement signal to noise ratio and contrast ratio.

  7. NSCT-based multimodal medical image fusion using pulse-coupled neural network and modified spatial frequency.

    PubMed

    Das, Sudeb; Kundu, Malay Kumar

    2012-10-01

    In this article, a novel multimodal medical image fusion (MIF) method based on non-subsampled contourlet transform (NSCT) and pulse-coupled neural network (PCNN) is presented. The proposed MIF scheme exploits the advantages of both the NSCT and the PCNN to obtain better fusion results. The source medical images are first decomposed by NSCT. The low-frequency subbands (LFSs) are fused using the 'max selection' rule. For fusing the high-frequency subbands (HFSs), a PCNN model is utilized. Modified spatial frequency in NSCT domain is input to motivate the PCNN, and coefficients in NSCT domain with large firing times are selected as coefficients of the fused image. Finally, inverse NSCT (INSCT) is applied to get the fused image. Subjective as well as objective analysis of the results and comparisons with state-of-the-art MIF techniques show the effectiveness of the proposed scheme in fusing multimodal medical images.

  8. Fiber-laser frequency combs for the generation of tunable single-frequency laser lines, mm- and THz-waves and sinc-shaped Nyquist pulses

    NASA Astrophysics Data System (ADS)

    Schneider, Thomas

    2015-03-01

    High-quality frequency comb sources like femtosecond-lasers have revolutionized the metrology of fundamental physical constants. The generated comb consists of frequency lines with an equidistant separation over a bandwidth of several THz. This bandwidth can be broadened further to a super-continuum of more than an octave through propagation in nonlinear media. The frequency separation between the lines is defined by the repetition rate and the width of each comb line can be below 1 Hz, even without external stabilization. By extracting just one of these lines, an ultra-narrow linewidth, tunable laser line for applications in communications and spectroscopy can be generated. If two lines are extracted, the superposition of these lines in an appropriate photo-mixer produces high-quality millimeter- and THz-waves. The extraction of several lines can be used for the creation of almost-ideally sinc-shaped Nyquist pulses, which enable optical communications with the maximum-possible baud rate. Especially combs generated by low-cost, small-footprint fs-fiber lasers are very promising. However due to the resonator length, the comb frequencies have a typical separation of 80 - 100 MHz, far too narrow for the selection of single tones with standard optical filters. Here the extraction of single lines of an fs-fiber laser by polarization pulling assisted stimulated Brillouin scattering is presented. The application of these extracted lines as ultra-narrow, stable and tunable laser lines, for the generation of very high-quality mm and THz-waves with an ultra-narrow linewidth and phase noise and for the generation of sinc-shaped Nyquist pulses with arbitrary bandwidth and repetition rate is discussed.

  9. Discovery of Anomalously Strong (Giant) Pulses from the Pulsar B1133+16 (J1136+1551) at a Frequency of 111~MHz

    NASA Astrophysics Data System (ADS)

    Kazantsev, N. A.; Potapov, V. A.

    2015-10-01

    In the framework of our program of the Northern Hemisphere pulsar survey we have found anomalously strong pulses from the pulsar B1133+16 (J1136+1551). The observations were carried out at a frequency of 111 MHz using the Large Phased Array (LPA) radio telescope and digital pulsar processor. The peak flux density of the strongest observed individual pulse was 86 times as strong as the dynamic averaged (mean) profile, and a typical anomalous pulse has a duration of approximately 0.2 of the duration of the mean profile for the observational session. The flux density of individual pulses has a complex distribution function, different for the 1st and 2nd main components of the pulse and can be fitted with a combination of log-normal and power-law distributions. Thus, we can argue that the pulsar B1133+16 generates pulses having main features of the Giant Pulses (GP).

  10. Multi-frequency, multi-technique pulsed EPR investigation of the copper binding site of murine amyloid β peptide.

    PubMed

    Kim, Donghun; Bang, Jeong Kyu; Kim, Sun Hee

    2015-01-26

    Copper-amyloid peptides are proposed to be the cause of Alzheimer's disease, presumably by oxidative stress. However, mice do not produce amyloid plaques and thus do not suffer from Alzheimer's disease. Although much effort has been focused on the structural characterization of the copper- human amyloid peptides, little is known regarding the copper-binding mode in murine amyloid peptides. Thus, we investigated the structure of copper-murine amyloid peptides through multi-frequency, multi-technique pulsed EPR spectroscopy in conjunction with specific isotope labeling. Based on our pulsed EPR results, we found that Ala2, Glu3, His6, and His14 are directly coordinated with the copper ion in murine amyloid β peptides at pH 8.5. This is the first detailed structural characterization of the copper-binding mode in murine amyloid β peptides. This work may advance the knowledge required for developing inhibitors of Alzheimer's disease.

  11. High-order harmonic generation by chirped and self-guided femtosecond laser pulses. II. Time-frequency analysis

    SciTech Connect

    Tosa, V.; Kim, H.T.; Kim, I.J.; Nam, C.H.

    2005-06-15

    We present a time-dependent analysis of high-order harmonics generated by a self-guided femtosecond laser pulse propagating through a long gas jet. A three-dimensional model is used to calculate the harmonic fields generated by laser pulses, which only differ by the sign of their initial chirp. The time-frequency distributions of the single-atom dipole and harmonic field reveal the dynamics of harmonic generation in the cutoff. A time-dependent phase-matching calculation was performed, taking into account the self-phase modulation of the laser field. Good phase matching holds for only few optical cycles, being dependent on the electron trajectory. When the cutoff trajectory is phase matched, emitted harmonics are locked in phase and the emission intensity is maximized.

  12. Radio-frequency plasma cleaning for mitigation of high-power microwave-pulse shortening in a coaxial gyrotron

    NASA Astrophysics Data System (ADS)

    Cohen, William E.; Gilgenbach, Ronald M.; Jaynes, Reginald L.; Peters, Christopher W.; Lopez, Mike R.; Lau, Y. Y.; Anderson, Scott A.; Brake, Mary L.; Spencer, Thomas A.

    2000-12-01

    Results are reported demonstrating that radio-frequency (rf) plasma cleaning is an effective technique for mitigating microwave-pulse shortening (i.e., lengthening the pulse) in a multimegawatt, large-orbit, coaxial gyrotron. Cleaning plasmas were generated by 50 W of rf power at 13.56 MHz in nitrogen fill gas in the pressure range 15-25 mTorr. Improvements in the averaged microwave energy output of this high-power-microwave device ranged from 15% to 245% for different initial conditions and cleaning protocols. The mechanism for this improvement is believed to be rf plasma sputtering of excess water vapor from the cavity/waveguide and subsequent removal of the contaminant by cryogenic vacuum pumps.

  13. Sub-picosecond pulse and terahertz optical frequency comb generation by monolithically integrated linear mode-locked laser

    NASA Astrophysics Data System (ADS)

    Lo, Mu-Chieh; Guzmán, Robinson; Ali, Muhsin; Santos, Rui; Augustin, Luc; Carpintero, Guillermo

    2017-05-01

    We report on a record broad 3-dB bandwidth of 14 nm ( 1.8 THz around 1532 nm) optical frequency comb generated from a passively mode-locked quantum-well (QW) laser in the form of photonic integrated circuits through an InP generic photonic integration technology platform. This 21.5-GHz colliding-pulse mode-locked laser cavity is defined by two on-chip reflectors incorporating intracavity phase modulators followed by an out-of-cavity SOA as booster. Under certain operating conditions, an ultra-wide spectral bandwidth is achieved along with an autocorrelation trace confirming the mode locking nature exhibiting a pulse width of 0.35 ps. The beat note RF spectrum has a linewidth of sub-MHz and 35-dB SNR.

  14. Spin-echo magnetic resonance spectroscopic imaging at 7 T with frequency-modulated refocusing pulses.

    PubMed

    Zhu, He; Soher, Brian J; Ouwerkerk, Ronald; Schär, Michael; Barker, Peter B

    2013-05-01

    Two approaches to high-resolution SENSE-encoded magnetic resonance spectroscopic imaging (MRSI) of the human brain at 7 Tesla (T) with whole-slice coverage are described. Both sequences use high-bandwidth radiofrequency pulses to reduce chemical shift displacement artifacts, SENSE-encoding to reduce scan time, and dual-band water and lipid suppression optimized for 7 T. Simultaneous B0 and transmit B1 mapping was also used for both sequences to optimize field homogeneity using high-order shimming and determine optimum radiofrequency transmit level, respectively. One sequence ("Hahn-MRSI") used reduced flip angle (90°) refocusing pulses for lower radiofrequency power deposition, while the other sequence used adiabatic fast passage refocusing pulses for improved sensitivity and reduced signal dependence on the transmit-B1 level. In four normal subjects, adiabatic fast passage-MRSI showed a signal-to-noise ratio improvement of 3.2±0.5 compared to Hahn-MRSI at the same spatial resolution, pulse repetition time, echo time, and SENSE-acceleration factor. An interleaved two-slice Hahn-MRSI sequence is also demonstrated to be experimentally feasible.

  15. High-voltage nanosecond pulses in a low-pressure radio-frequency discharge.

    PubMed

    Pustylnik, M Y; Hou, L; Ivlev, A V; Vasilyak, L M; Couëdel, L; Thomas, H M; Morfill, G E; Fortov, V E

    2013-06-01

    An influence of a high-voltage (3-17 kV) 20 ns pulse on a weakly-ionized low-pressure (0.1-10 Pa) capacitively coupled radiofrequency (RF) argon plasma is studied experimentally. The plasma evolution after pulse exhibits two characteristic regimes: a bright flash, occurring within 100 ns after the pulse (when the discharge emission increases by 2-3 orders of magnitude over the steady-state level), and a dark phase, lasting a few hundreds μs (when the intensity of the discharge emission drops significantly below the steady-state level). The electron density increases during the flash and remains very large at the dark phase. 1D3V particle-in-cell simulations qualitatively reproduce both regimes and allow for detailed analysis of the underlying mechanisms. It is found that the high-voltage nanosecond pulse is capable of removing a significant fraction of plasma electrons out of the discharge gap, and that the flash is the result of the excitation of gas atoms, triggered by residual electrons accelerated in the electric field of immobile bulk ions. The secondary emission from the electrodes due to vacuum UV radiation plays an important role at this stage. High-density plasma generated during the flash provides efficient screening of the RF field (which sustains the steady-state plasma). This leads to the electron cooling and, hence, onset of the dark phase.

  16. Generation of surface waves and low-frequency radiation under exposure of a conductor to a laser pulse focused by a cylindrical lens

    SciTech Connect

    Uryupin, S A; Frolov, A A

    2014-09-30

    We have developed a theory of generation of low-frequency radiation and surface waves under the pondermotive action of a femtosecond laser pulse irradiating a conductor along the normal and focused by a cylindrical lens. It is shown that for the chosen focusing method and specified values of laser pulse duration and flux density it is possible to significantly increase the total energy of both surface waves and low-frequency radiation. (terahertz radiation)

  17. Control of Reactive Species Generated by Low-frequency Biased Nanosecond Pulse Discharge in Atmospheric Pressure Plasma Effluent

    NASA Astrophysics Data System (ADS)

    Takashima, Keisuke; Kaneko, Toshiro

    2016-09-01

    The control of hydroxyl radical and the other gas phase species generation in the ejected gas through air plasma (air plasma effluent) has been experimentally studied, which is a key to extend the range of plasma treatment. Nanosecond pulse discharge is known to produce high reduced electric field (E/N) discharge that leads to efficient generation of the reactive species than conventional low frequency discharge, while the charge-voltage cycle in the low frequency discharge is known to be well-controlled. In this study, the nanosecond pulse discharge biased with AC low frequency high voltage is used to take advantages of these discharges, which allows us to modulate the reactive species composition in the air plasma effluent. The utilization of the gas-liquid interface and the liquid phase chemical reactions between the modulated long-lived reactive species delivered from the air plasma effluent could realize efficient liquid phase chemical reactions leading to short-lived reactive species production far from the air plasma, which is crucial for some plasma agricultural applications.

  18. Experimental research on a 12.1 K gas-coupled two-stage high frequency pulse tube cryocooler

    NASA Astrophysics Data System (ADS)

    Xiaoshuang, Zhu; Yuan, Zhou; Wenxiu, Zhu; Wei, Dai; Junjie, Wang

    2017-02-01

    High frequency pulse tube cryocoolers (HFPTC) have been widely used in many fields like physics experimental research and aerospace, for no moving part in cold region, low vibration and long life. A gas-coupled two-stage high frequency pulse tube cryocooler with single compressor is introduced in this paper. In the first stage of the cryocooler, double-inlet and multi-bypass has been adopted as phase shifters. To get a better performance in phase shifting the reservoir and the inertance tube of the second stage has been located on the cold head of the first stage. With SS mesh screen as the regenerator of both stage, no-load temperature of 13.5K has been achieved. To improve the heat capacity of the regenerator of the second stage magnetic material Er3Ni has been employed in the second stage as regenerator matrix. With the charge pressure of 1.8MPa, input power of 260W and operating frequency of 23.5 Hz, the no-load temperature of 12.1K has been achieved.

  19. High-speed pulsed mixing in a short distance with high-frequency switching of pumping from three inlets

    NASA Astrophysics Data System (ADS)

    Sugano, K.; Nakata, A.; Tsuchiya, T.; Tabata, O.

    2015-08-01

    In this study, we propose a mixing method using alternate pulsed flows from three inlets with flow direction control. In conventional pulsed mixing, a residual flow near the sidewalls inhibits the rapid mixing of two solutions at high switching frequency. In this study, we addressed this issue in order to perform rapid mixing in a short distance with a low Reynolds number. We fabricated a microfluidic mixing device consisting of a cross-shaped mixing channel with three inlet microchannels and three valveless micropumps. In conventional T-shaped or Y-shaped mixing channels, a residual flow is observed because of the incomplete switching of solutions. The three inlet configuration enabled us to split the residual flow at a switching frequency of pumping of up to 200 Hz, thus resulting in rapid mixing. Furthermore, by controlling the flow direction at the confluent area using the reverse flow of the micropump, the mixing speed was dramatically increased because of the complete switching of the two solutions. As a result, we achieved the mixing time of 3.6 ms and the mixing length of 20.7 µm, which were necessary to achieve a 90% mixing ratio at a high micropump switching frequency of 400 Hz and reverse flow ratio of 1/4.

  20. Adaptive SSVEP-based BCI system with frequency and pulse duty-cycle stimuli tuning design.

    PubMed

    Shyu, Kuo-Kai; Chiu, Yun-Jen; Lee, Po-Lei; Liang, Jia-Ming; Peng, Shao-Hwo

    2013-09-01

    This study aims to design a steady state visual evoked potentials (SSVEP) based brain-computer interface (BCI) system with only three electrodes. It is known that low frequency flickering induces more intensive SSVEP, but might cause users feel uncomfortable and easily tired. Therefore, this paper proposes a novel middle/high frequency flickering stimulus. However, users show different SSVEP responses when gazing at the same stimuli. It is improper to design fixed frequency flickering stimuli for all users. This study firstly proposes a strategy to adjust the stimuli frequency for each user that could cause better SSVEP. Moreover, to further enhance the SSVEP, this study incorporates flickering duty-cycle for stimuli design, which has been discussed less for SSVEP-based BCI systems. The proposed system consists of two modes, flicker frequency/duty-cycle selection mode and application mode. The flicker frequency/duty-cycle selection mode obtains two best frequencies between 24 and 36 Hz with their related optimal duty-cycle. Then the system goes into the application mode to control the devices. A new fact that has been found is that the optimal flicker frequency and duty-cycle do not vary with time. It means once the optical flicker frequency and duty-cycle is determined the first time, flicker frequency/duty-cycle selection mode does not need to operate the next time. Furthermore, the phase coding technology is used to extend the one command/one frequency to multi command/one frequency. Experimental results show the proposed system has good performance with average accuracy 95% and average command transfer interval 4.4925 s per command.