Science.gov

Sample records for lhc generalizing mt2

  1. Dark Matter Particle Spectroscopy at the LHC: Generalizing M(T2) to Asymmetric Event Topologies

    SciTech Connect

    Konar, Partha; Kong, Kyoungchul; Matchev, Konstantin T.; Park, Myeonghun; /Florida U.

    2012-04-03

    We consider SUSY-like missing energy events at hadron colliders and critically examine the common assumption that the missing energy is the result of two identical missing particles. In order to experimentally test this hypothesis, we generalize the subsystem M{sub T2} variable to the case of asymmetric event topologies, where the two SUSY decay chains terminate in different 'children' particles. In this more general approach, the endpoint M{sub T2(max)} of the M{sub T2} distribution now gives the mass {tilde M}p({tilde M}{sub c}{sup (a)}, {tilde M}{sub c}{sup (b)}) of the parent particles as a function of two input children masses {tilde M}{sub c}{sup (a)} and {tilde M}{sub c}{sup (b)}. We propose two methods for an independent determination of the individual children masses M{sub c}{sup (a)} and M{sub c}{sup (b)}. First, in the presence of upstream transverse momentum PUTM the corresponding function {tilde M}p({tilde M}{sub c}{sup (a)}, {tilde M}{sub c}{sup (b)}, P{sub UTM}) is independent of P{sub UTM} at precisely the right values of the children masses. Second, the previously discussed MT2 'kink' is now generalized to a 'ridge' on the 2-dimensional surface {tilde M}p({tilde M}{sub c}{sup (a)}, {tilde M}{sub c}{sup (b)}). As we show in several examples, quite often there is a special point along that ridge which marks the true values of the children masses. Our results allow collider experiments to probe a multi-component dark matter sector directly and without any theoretical prejudice.

  2. Stop and sbottom search using dileptonic MT2 variable and boosted top technique at the LHC

    NASA Astrophysics Data System (ADS)

    Chakraborty, Amit; Ghosh, Dilip Kumar; Ghosh, Diptimoy; Sengupta, Dipan

    2013-10-01

    The ATLAS and CMS experiments at the CERN LHC have collected about 25 fb-1 of data each at the end of their 8 TeV run, and ruled out a huge swath of parameter space in the context of Minimally Supersymmetric Standard Model (MSSM). Limits on masses of the gluino and the squarks of the first two generations have been pushed to above 1 TeV. Light third generation squarks namely stop and sbottom of sub-TeV masses, on the other hand, are still allowed by their direct search limits. Interestingly, the discovery of a Standard Model (SM) higgs boson like particle with a mass of ~ 125 GeV favours a light third generation which is also motivated by naturalness arguments. Decays of stop and sbottom quarks can in general produce a number of distinct final states which necessitate different search strategies in the collider experiments. In this paper we, on the other hand, propose a general search strategy to look for third generation squarks in the final state which contains a top quark in the sample along with two additional hard leptons and substantial missing transverse momentum. We illustrate that a search strategy using the dileptonic MT2, the effective mass meff and jet substructure to reconstruct the hadronic top quark can be very effective to reduce the SM backgrounds. With the proposed search strategy, we estimate that the third generation squarks with masses up to about 900 GeV can be probed at the 14 TeV LHC with 100 fb-1 luminosity. We also interpret our results in two simplified scenarios where we consider the stop (sbottom) pair production followed by their subsequent decay to a top quark and the second lightest neutralino (lightest chargino). In this case also we find that stop (sbottom) mass up to 1 TeV (0.9 TeV) can be discovered at the 14 TeV LHC with 100 fb-1 integrated luminosity.

  3. General-purpose event generators for LHC physics

    SciTech Connect

    Buckley, Andy; Butterworth, Jonathan; Gieseke, Stefan; Grellscheid, David; Hoche, Stefan; Hoeth, Hendrik; Krauss, Frank; Lonnblad, Leif; Nurse, Emily; Richardson, Peter; Schumann, Steffen; Seymour, Michael H.; Sjostrand, Torbjorn; Skands, Peter; Webber, Bryan; /Cambridge U.

    2011-03-03

    We review the physics basis, main features and use of general-purpose Monte Carlo event generators for the simulation of proton-proton collisions at the Large Hadron Collider. Topics included are: the generation of hard-scattering matrix elements for processes of interest, at both leading and next-to-leading QCD perturbative order; their matching to approximate treatments of higher orders based on the showering approximation; the parton and dipole shower formulations; parton distribution functions for event generators; non-perturbative aspects such as soft QCD collisions, the underlying event and diffractive processes; the string and cluster models for hadron formation; the treatment of hadron and tau decays; the inclusion of QED radiation and beyond-Standard-Model processes. We describe the principal features of the Ariadne, Herwig++, Pythia 8 and Sherpa generators, together with the Rivet and Professor validation and tuning tools, and discuss the physics philosophy behind the proper use of these generators and tools. This review is aimed at phenomenologists wishing to understand better how parton-level predictions are translated into hadron-level events as well as experimentalists wanting a deeper insight into the tools available for signal and background simulation at the LHC.

  4. MT-2 cell tropism as prognostic marker for disease progression in human immunodeficiency virus type 1 infection.

    PubMed Central

    Karlsson, A; Parsmyr, K; Sandström, E; Fenyö, E M; Albert, J

    1994-01-01

    The ability of human immunodeficiency virus type 1 (HIV-1) isolates to replicate in MT-2 cells was investigated as a prognostic marker for disease progression and CD4+ lymphocyte depletion in 53 HIV-1-infected, asymptomatic individuals. MT-2-negative viruses were isolated from 49% of the patients both early and late during the follow-up period; 38% converted from being MT-2 negative to MT-2 positive, while 11% were MT-2 positive throughout the study. One individual showed a fluctuating virus phenotype. The loss of CD4+ lymphocytes was significantly more rapid in MT-2-positive patients. We found a broad spectrum of CD4+ lymphocyte changes in patients whose virus changed its MT-2 tropism. Our data suggest that the changes could be divided into three general patterns. A stable or slowly decreasing CD4+ lymphocyte count changed into a more rapid fall in 44% of the patients, no significant change in rate of decline could be noted in 44% of the patients, while a stable CD4+ lymphocyte level after a change in MT-2 tropism was noted in 12% of the patients. A correlation between MT-2 tropism and clinical symptoms was also noted. Half of the patients with MT-2-negative virus throughout the study were still asymptomatic after a mean follow-up time of 80 months, while only 15% of those who converted remained asymptomatic. All patients with MT-2-positive viruses at the time of inclusion in the study developed HIV-1-related symptoms, and half of them died during the study. The MT-2 status of 16 patients, could be determined at the time of AIDS diagnosis; 50% were Mt-2 positive, while 50% were MT-2 negative. No difference in AIDS-defining diagnoses or CD4+ lymphocyte counts at the time of diagnosis was noted. Knowledge of the HIV-1 phenotype may improve the early recognition of progressive disease. PMID:7908672

  5. The role of MT2-MMP in cancer progression

    SciTech Connect

    Ito, Emiko; Yana, Ikuo; Fujita, Chisato; Irifune, Aiko; Takeda, Maki; Madachi, Ayako; Mori, Seiji; Hamada, Yoshinosuke; Kawaguchi, Naomasa; Matsuura, Nariaki

    2010-03-05

    The role of MT2-MMP in cancer progression remains to be elucidated in spite of many reports on MT1-MMP. Using a human fibrosarcoma cell, HT1080 and a human gastric cancer cell, TMK-1, endogenous expression of MT1-MMP or MT2-MMP was suppressed by siRNA induction to examine the influence of cancer progression in vitro and in vivo. In HT1080 cells, positive both in MT1-MMP and MT2-MMP, the migration as well as the invasion was impaired by MT1-MMP or MT2-MMP suppression. Also cell proliferation in three dimensional (3D) condition was inhibited by MT1-MMP or MT2-MMP suppression and tumor growth in the nude mice transplanted with tumor cells were reduced either MT1-MMP or MT2-MMP suppression with a prolongation of survival time in vivo. MT2-MMP suppression induces more inhibitory effects on 3D proliferation and in vivo tumor growth than MT1-MMP. On the other hand, TMK-1 cells, negative in MT1-MMP and MMP-2 but positive in MT2-MMP, all the migratory, invasive, and 3D proliferative activities in TMK-1 are decreased only by MT2-MMP suppression. These results indicate MT2-MMP might be involved in the cancer progression more than or equal to MT1-MMP independently of MMP-2 and MT1-MMP.

  6. Convergence of Melatonin and Serotonin (5-HT) Signaling at MT2/5-HT2C Receptor Heteromers*

    PubMed Central

    Kamal, Maud; Gbahou, Florence; Guillaume, Jean-Luc; Daulat, Avais M.; Benleulmi-Chaachoua, Abla; Luka, Marine; Chen, Patty; Kalbasi Anaraki, Dina; Baroncini, Marc; Mannoury la Cour, Clotilde; Millan, Mark J.; Prevot, Vincent; Delagrange, Philippe; Jockers, Ralf

    2015-01-01

    Inasmuch as the neurohormone melatonin is synthetically derived from serotonin (5-HT), a close interrelationship between both has long been suspected. The present study reveals a hitherto unrecognized cross-talk mediated via physical association of melatonin MT2 and 5-HT2C receptors into functional heteromers. This is of particular interest in light of the “synergistic” melatonin agonist/5-HT2C antagonist profile of the novel antidepressant agomelatine. A suite of co-immunoprecipitation, bioluminescence resonance energy transfer, and pharmacological techniques was exploited to demonstrate formation of functional MT2 and 5-HT2C receptor heteromers both in transfected cells and in human cortex and hippocampus. MT2/5-HT2C heteromers amplified the 5-HT-mediated Gq/phospholipase C response and triggered melatonin-induced unidirectional transactivation of the 5-HT2C protomer of MT2/5-HT2C heteromers. Pharmacological studies revealed distinct functional properties for agomelatine, which shows “biased signaling.” These observations demonstrate the existence of functionally unique MT2/5-HT2C heteromers and suggest that the antidepressant agomelatine has a distinctive profile at these sites potentially involved in its therapeutic effects on major depression and generalized anxiety disorder. Finally, MT2/5-HT2C heteromers provide a new strategy for the discovery of novel agents for the treatment of psychiatric disorders. PMID:25770211

  7. Convergence of melatonin and serotonin (5-HT) signaling at MT2/5-HT2C receptor heteromers.

    PubMed

    Kamal, Maud; Gbahou, Florence; Guillaume, Jean-Luc; Daulat, Avais M; Benleulmi-Chaachoua, Abla; Luka, Marine; Chen, Patty; Kalbasi Anaraki, Dina; Baroncini, Marc; Mannoury la Cour, Clotilde; Millan, Mark J; Prevot, Vincent; Delagrange, Philippe; Jockers, Ralf

    2015-05-01

    Inasmuch as the neurohormone melatonin is synthetically derived from serotonin (5-HT), a close interrelationship between both has long been suspected. The present study reveals a hitherto unrecognized cross-talk mediated via physical association of melatonin MT2 and 5-HT2C receptors into functional heteromers. This is of particular interest in light of the "synergistic" melatonin agonist/5-HT2C antagonist profile of the novel antidepressant agomelatine. A suite of co-immunoprecipitation, bioluminescence resonance energy transfer, and pharmacological techniques was exploited to demonstrate formation of functional MT2 and 5-HT2C receptor heteromers both in transfected cells and in human cortex and hippocampus. MT2/5-HT2C heteromers amplified the 5-HT-mediated Gq/phospholipase C response and triggered melatonin-induced unidirectional transactivation of the 5-HT2C protomer of MT2/5-HT2C heteromers. Pharmacological studies revealed distinct functional properties for agomelatine, which shows "biased signaling." These observations demonstrate the existence of functionally unique MT2/5-HT2C heteromers and suggest that the antidepressant agomelatine has a distinctive profile at these sites potentially involved in its therapeutic effects on major depression and generalized anxiety disorder. Finally, MT2/5-HT2C heteromers provide a new strategy for the discovery of novel agents for the treatment of psychiatric disorders. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  8. Accumulation of Mitochondrial P450MT2, NH2-terminal Truncated Cytochrome P4501A1 in Rat Brain during Chronic Treatment with β-Naphthoflavone

    PubMed Central

    Boopathi, Ettickan; Anandatheerthavarada, Hindupur K.; Bhagwat, Shripad V.; Biswas, Gopa; Fang, Ji-Kang; Avadhani, Narayan G.

    2013-01-01

    The biochemical and molecular characteristics of cytochrome P4501A1 targeted to rat brain mitochondria was studied to determine the generality of the targeting mechanism previously described for mitochondrial cytochrome P450MT2 (P450MT2) from rat liver. In rat brain and C6 glioma cells chronically exposed to β-na-phoflavone (BNF), P450MT2 content reached 50 and 95% of the total cellular pool, respectively. P450MT2 from 10 days of BNF-treated rat brain was purified to over 85% purity using hydrophobic chromatography followed by adrenodoxin affinity binding. Purified brain P450MT2 consisted of two distinct molecular species with NH2 termini identical to liver mitochondrial forms. These results confirm the specificity of endoprotease-processing sites. The purified P450MT2 showed a preference for adrenodoxin + adrenodoxin reductase electron donor system and exhibited high erythromycin N-demethylation activity. Brain mitoplasts from 10-day BNF-treated rats and also purified P450MT2 exhibited high N-de-methylation activities for a number of neuroactive drugs, including trycyclic anti-depressants, anti-convulsants, and opiates. At 10 days of BNF treatment, the mitochondrial metabolism of these neuroactive drugs represented about 85% of the total tissue activity. These results provide new insights on the role of P450MT2 in modulating the pharmacological potencies of different neuroactive drugs in chronically exposed individuals. PMID:10915793

  9. MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective.

    PubMed

    Liu, Jiabei; Clough, Shannon J; Hutchinson, Anthony J; Adamah-Biassi, Ekue B; Popovska-Gorevski, Marina; Dubocovich, Margarita L

    2016-01-01

    Melatonin, or 5-methoxy-N-acetyltryptamine, is synthesized and released by the pineal gland and locally in the retina following a circadian rhythm, with low levels during the day and elevated levels at night. Melatonin activates two high-affinity G protein-coupled receptors, termed MT1 and MT2, to exert beneficial actions in sleep and circadian abnormality, mood disorders, learning and memory, neuroprotection, drug abuse, and cancer. Progress in understanding the role of melatonin receptors in the modulation of sleep and circadian rhythms has led to the discovery of a novel class of melatonin agonists for treating insomnia, circadian rhythms, mood disorders, and cancer. This review describes the pharmacological properties of a slow-release melatonin preparation (i.e., Circadin®) and synthetic ligands (i.e., agomelatine, ramelteon, tasimelteon), with emphasis on identifying specific therapeutic effects mediated through MT1 and MT2 receptor activation. Discovery of selective ligands targeting the MT1 or the MT2 melatonin receptors may promote the development of novel and more efficacious therapeutic agents.

  10. MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective

    PubMed Central

    Liu, Jiabei; Clough, Shannon J.; Hutchinson, Anthony J.; Adamah-Biassi, Ekue B.; Popovska-Gorevski, Marina; Dubocovich, Margarita L.

    2016-01-01

    Melatonin, or 5-methoxy-N-acetyltryptamine, is synthesized and released by the pineal gland and locally in the retina following a circadian rhythm, with low levels during the day and elevated levels at night. Melatonin activates two high-affinity G protein–coupled receptors, termed MT1 and MT2, to exert beneficial actions in sleep and circadian abnormality, mood disorders, learning and memory, neuroprotection, drug abuse, and cancer. Progress in understanding the role of melatonin receptors in the modulation of sleep and circadian rhythms has led to the discovery of a novel class of melatonin agonists for treating insomnia, circadian rhythms, mood disorders, and cancer. This review describes the pharmacological properties of a slow-release melatonin preparation (i.e., Circadin®) and synthetic ligands (i.e., agomelatine, ramelteon, tasimelteon), with emphasis on identifying specific therapeutic effects mediated through MT1 and MT2 receptor activation. Discovery of selective ligands targeting the MT1 or the MT2 melatonin receptors may promote the development of novel and more efficacious therapeutic agents. PMID:26514204

  11. Inclusive B-meson production at the LHC in the general-mass variable-flavor-number scheme

    SciTech Connect

    Kniehl, B. A.; Kramer, G.; Schienbein, I.

    2011-11-01

    We calculate the next-to-leading-order cross section for the inclusive production of B mesons in pp collisions in the general-mass variable-flavor-number scheme, an approach that takes into account the finite mass of the b quarks. We use realistic evolved nonperturbative fragmentation functions obtained from fits to e{sup +}e{sup -} data and compare our results for the transverse-momentum and rapidity distributions at a center-of-mass energy of 7 TeV with recent data from the CMS Collaboration at the CERN LHC. We find good agreement, in particular, at large values of p{sub T}.

  12. The BSM-AI project: SUSY-AI-generalizing LHC limits on supersymmetry with machine learning

    NASA Astrophysics Data System (ADS)

    Caron, Sascha; Kim, Jong Soo; Rolbiecki, Krzysztof; de Austri, Roberto Ruiz; Stienen, Bob

    2017-04-01

    A key research question at the Large Hadron Collider is the test of models of new physics. Testing if a particular parameter set of such a model is excluded by LHC data is a challenge: it requires time consuming generation of scattering events, simulation of the detector response, event reconstruction, cross section calculations and analysis code to test against several hundred signal regions defined by the ATLAS and CMS experiments. In the BSM-AI project we approach this challenge with a new idea. A machine learning tool is devised to predict within a fraction of a millisecond if a model is excluded or not directly from the model parameters. A first example is SUSY-AI, trained on the phenomenological supersymmetric standard model (pMSSM). About 300, 000 pMSSM model sets - each tested against 200 signal regions by ATLAS - have been used to train and validate SUSY-AI. The code is currently able to reproduce the ATLAS exclusion regions in 19 dimensions with an accuracy of at least 93%. It has been validated further within the constrained MSSM and the minimal natural supersymmetric model, again showing high accuracy. SUSY-AI and its future BSM derivatives will help to solve the problem of recasting LHC results for any model of new physics. SUSY-AI can be downloaded from http://susyai.hepforge.org/. An on-line interface to the program for quick testing purposes can be found at http://www.susy-ai.org/.

  13. The BSM-AI project: SUSY-AI-generalizing LHC limits on supersymmetry with machine learning.

    PubMed

    Caron, Sascha; Kim, Jong Soo; Rolbiecki, Krzysztof; de Austri, Roberto Ruiz; Stienen, Bob

    2017-01-01

    A key research question at the Large Hadron Collider is the test of models of new physics. Testing if a particular parameter set of such a model is excluded by LHC data is a challenge: it requires time consuming generation of scattering events, simulation of the detector response, event reconstruction, cross section calculations and analysis code to test against several hundred signal regions defined by the ATLAS and CMS experiments. In the BSM-AI project we approach this challenge with a new idea. A machine learning tool is devised to predict within a fraction of a millisecond if a model is excluded or not directly from the model parameters. A first example is SUSY-AI, trained on the phenomenological supersymmetric standard model (pMSSM). About 300, 000 pMSSM model sets - each tested against 200 signal regions by ATLAS - have been used to train and validate SUSY-AI. The code is currently able to reproduce the ATLAS exclusion regions in 19 dimensions with an accuracy of at least [Formula: see text]. It has been validated further within the constrained MSSM and the minimal natural supersymmetric model, again showing high accuracy. SUSY-AI and its future BSM derivatives will help to solve the problem of recasting LHC results for any model of new physics. SUSY-AI can be downloaded from http://susyai.hepforge.org/. An on-line interface to the program for quick testing purposes can be found at http://www.susy-ai.org/.

  14. REM sleep deprivation promotes a dopaminergic influence in the striatal MT2 anxiolytic-like effects

    PubMed Central

    Noseda, Ana Carolina D.; Targa, Adriano D.S.; Rodrigues, Lais S.; Aurich, Mariana F.; Lima, Marcelo M.S.

    2015-01-01

    The aim of this study was to investigate the possible anxiolytic-like effects of striatal MT2 activation, and its counteraction induced by the selective blockade of this receptor. Furthermore, we analyzed this condition under the paradigm of rapid eye movement (REM) sleep deprivation (REMSD) and the animal model of Parkinson’s disease (PD) induced by rotenone. Male Wistar rats were infused with intranigral rotenone (12 μg/μL), and 7 days later were subjected to 24 h of REMSD. Afterwards the rats underwent striatal micro-infusions of selective melatonin MT2 receptor agonist, 8-M-PDOT (10 μg/μL) or selective melatonin MT2 receptor antagonist, 4-P-PDOT (5 μg/μL) or vehicle. Subsequently, the animals were tested in the open-field (OP) and elevated plus maze (EPM) tests. Results indicated that the activation of MT2 receptors produced anxiolytic-like effects. In opposite, the MT2 blockade did not show an anxiogenic-like effect. Besides, REMSD induced anxiolytic-like effects similar to 8-M-PDOT. MT2 activation generated a prevalent locomotor increase compared to MT2 blockade in the context of REMSD. Together, these results suggest a striatal MT2 modulation associated to the REMSD-induced dopaminergic supersensitivity causing a possible dopaminergic influence in the MT2 anxiolytic-like effects in the intranigral rotenone model of PD. PMID:27226821

  15. Using MT2 to distinguish dark matter stabilization symmetries

    NASA Astrophysics Data System (ADS)

    Agashe, Kaustubh; Kim, Doojin; Walker, Devin G. E.; Zhu, Lijun

    2011-09-01

    We examine the potential of using colliders to distinguish models with parity (Z2) stabilized dark matter (DM) from models in which the DM is stabilized by other symmetries, taking the latter to be a Z3 symmetry for illustration. The key observation is that a heavier mother particle charged under a Z3 stabilization symmetry can decay into one or two DM particles along with standard model particles. This can be contrasted with the decay of a mother particle charged under a parity symmetry; typically, only one DM particle appears in the decay chain. The arXiv:1003.0899 studied the distributions of visible invariant mass from the decay of a single such mother particle in order to highlight the resulting distinctive signatures of Z3 symmetry versus parity symmetry stabilized dark matter candidates. We now describe a complementary study which focuses on decay chains of the two mother particles which are necessarily present in these events. We also include in our analysis the missing energy/momentum in the event. For the Z3 symmetry stabilized mothers, the resulting inclusive final state can have two, three or four DM particles. In contrast, models with Z2 symmetry can have only two. We show that the shapes and edges of the distribution of MT2-type variables, along with ratio of the visible momentum/energy on the two sides of the event, are powerful in distinguishing these different scenarios. Finally we conclude by outlining future work which focuses on reducing combinatoric ambiguities from reconstructing multijet events. Increasing the reconstruction efficiency can allow better reconstruction of events with two or three dark matter candidates in the final state.

  16. MT2DInvMatlab—A program in MATLAB and FORTRAN for two-dimensional magnetotelluric inversion

    NASA Astrophysics Data System (ADS)

    Lee, Seong Kon; Kim, Hee Joon; Song, Yoonho; Lee, Choon-Ki

    2009-08-01

    MT2DInvMatlab is an open-source MATLAB® software package for two-dimensional (2D) inversion of magnetotelluric (MT) data; it is written in mixed languages of MATLAB and FORTRAN. MT2DInvMatlab uses the finite element method (FEM) to compute 2D MT model responses, and smoothness-constrained least-squares inversion with a spatially variable regularization parameter algorithm to stabilize the inversion process and provide a high-resolution optimal earth model. It is also able to include terrain effects in inversion by incorporating topography into a forward model. This program runs under the MATLAB environment so that users can utilize the existing general interface of MATLAB, while some specific functions are written in FORTRAN 90 to speed up computation and reuse pre-existing FORTRAN code in the MATLAB environment with minimal modification. This program has been tested using synthetic models, including one with variable topography, and on field data. The results were assessed by comparing inverse models obtained with MT2DInvMatlab and with a non-linear conjugate gradient (NLCG) algorithm. In both tests the new inversion software reconstructs the subsurface resistivity structure very closely and provides an improvement in both resolution and stability.

  17. Dark matter particle spectroscopy at the LHC: generalizing M T2 to asymmetric event topologies

    NASA Astrophysics Data System (ADS)

    Konar, Partha; Kong, Kyoungchul; Matchev, Konstantin T.; Park, Myeonghun

    2010-04-01

    We consider SUSY-like missing energy events at hadron colliders and critically examine the common assumption that the missing energy is the result of two identical missing particles. In order to experimentally test this hypothesis, we generalize the subsystem M T2 variable to the case of asymmetric event topologies, where the two SUSY decay chains terminate in different “children” particles. In this more general approach, the endpoint M T2( max) of the M T2 distribution now gives the mass {tilde M_p}left( {tilde M_c^{(a)},tilde M_c^{(b)}} right) of the parent particles as a function of two input children masses tilde M_c^{(a)} and tilde M_c^{(b)} . We propose two methods for an independent determination of the individual children masses M ( a) c and M ( b) c . First, in the presence of upstream transverse momentum PUTM the corresponding function {tilde M_p}left( {tilde M_c^{(a)},tilde M_c^{(b)},{P_{text{UTM}}}} right) is independent of PUTM at precisely the right values of the children masses. Second, the previously discussed M T2 “kink” is now generalized to a “ridge” on the 2-dimensional surface {tilde M_p}left( {tilde M_c^{(a)},tilde M_c^{(b)}} right) . As we show in several examples, quite often there is a special point along that ridge which marks the true values of the children masses. Our results allow collider experiments to probe a multi-component dark matter sector directly and without any theoretical prejudice.

  18. Putative role of monoamines in the antidepressant-like mechanism induced by striatal MT2 blockade.

    PubMed

    Noseda, Ana Carolina D; Rodrigues, Lais S; Targa, Adriano D S; Aurich, Mariana F; Vital, Maria A B F; Da Cunha, Cláudio; Lima, Marcelo M S

    2014-12-15

    It has been observed that the secretion pattern of melatonin is modified in Parkinson's disease (PD). Hence, it is hypothesized that dysregulations of melatonin MT2 receptors may be involved in the installation of depression in PD patients. Together with recent evidence based on the use of the intranigral rotenone model of PD, have led to the hypothesis that modulating the striatal MT2 receptor could provide a more comprehensive understanding of the antidepressant properties triggered. To further investigate this issue, male Wistar rats were infused with intranigral rotenone (12μg/μL) and seven days later subjected to a rapid eye movement sleep deprivation (REMSD) for 24h. After, we injected within the striatum the MT2 selective agonist, 8-M-PDOT (10μg/μL), the MT2 selective antagonist, 4-P-PDOT (5μg/μL) or vehicle. Subsequently, they were tested in the forced swimming test and were allowed to perform the sleep rebound (REB). Then, the rats were re-tested, and the striatum, hippocampus and substantia nigra pars compacta (SNpc) were collected for neurochemical purposes. Results indicated substantial antidepressant effects promoted by the blockade of striatal MT2 receptors that were potentiated by REMSD. MT2 activation increased DA levels in the striatum and hippocampus, while MT2 blockade increase DA in the SNpc. 4-P-PDOT treatment of the rotenone REMSD group generated a decrement in 5-HT levels within the striatum, hippocampus and SNpc. However, increased 5-HT turnover was observed among these structures. Therefore, we demonstrated the neurochemical antidepressant effect induced by striatal MT2 blockage associated with REMSD in the rotenone model of PD.

  19. Earthworm Lumbricus rubellus MT-2: Metal Binding and Protein Folding of a True Cadmium-MT

    PubMed Central

    Kowald, Gregory R.; Stürzenbaum, Stephen R.; Blindauer, Claudia A.

    2016-01-01

    Earthworms express, as most animals, metallothioneins (MTs)—small, cysteine-rich proteins that bind d10 metal ions (Zn(II), Cd(II), or Cu(I)) in clusters. Three MT homologues are known for Lumbricus rubellus, the common red earthworm, one of which, wMT-2, is strongly induced by exposure of worms to cadmium. This study concerns composition, metal binding affinity and metal-dependent protein folding of wMT-2 expressed recombinantly and purified in the presence of Cd(II) and Zn(II). Crucially, whilst a single Cd7wMT-2 species was isolated from wMT-2-expressing E. coli cultures supplemented with Cd(II), expressions in the presence of Zn(II) yielded mixtures. The average affinities of wMT-2 determined for either Cd(II) or Zn(II) are both within normal ranges for MTs; hence, differential behaviour cannot be explained on the basis of overall affinity. Therefore, the protein folding properties of Cd- and Zn-wMT-2 were compared by 1H NMR spectroscopy. This comparison revealed that the protein fold is better defined in the presence of cadmium than in the presence of zinc. These differences in folding and dynamics may be at the root of the differential behaviour of the cadmium- and zinc-bound protein in vitro, and may ultimately also help in distinguishing zinc and cadmium in the earthworm in vivo. PMID:26742040

  20. Earthworm Lumbricus rubellus MT-2: Metal Binding and Protein Folding of a True Cadmium-MT.

    PubMed

    Kowald, Gregory R; Stürzenbaum, Stephen R; Blindauer, Claudia A

    2016-01-05

    Earthworms express, as most animals, metallothioneins (MTs)-small, cysteine-rich proteins that bind d(10) metal ions (Zn(II), Cd(II), or Cu(I)) in clusters. Three MT homologues are known for Lumbricus rubellus, the common red earthworm, one of which, wMT-2, is strongly induced by exposure of worms to cadmium. This study concerns composition, metal binding affinity and metal-dependent protein folding of wMT-2 expressed recombinantly and purified in the presence of Cd(II) and Zn(II). Crucially, whilst a single Cd₇wMT-2 species was isolated from wMT-2-expressing E. coli cultures supplemented with Cd(II), expressions in the presence of Zn(II) yielded mixtures. The average affinities of wMT-2 determined for either Cd(II) or Zn(II) are both within normal ranges for MTs; hence, differential behaviour cannot be explained on the basis of overall affinity. Therefore, the protein folding properties of Cd- and Zn-wMT-2 were compared by ¹H NMR spectroscopy. This comparison revealed that the protein fold is better defined in the presence of cadmium than in the presence of zinc. These differences in folding and dynamics may be at the root of the differential behaviour of the cadmium- and zinc-bound protein in vitro, and may ultimately also help in distinguishing zinc and cadmium in the earthworm in vivo.

  1. Molecular cloning and pharmacological characterization of rat melatonin MT1 and MT2 receptors.

    PubMed

    Audinot, Valérie; Bonnaud, Anne; Grandcolas, Line; Rodriguez, Marianne; Nagel, Nadine; Galizzi, Jean-Pierre; Balik, Ales; Messager, Sophie; Hazlerigg, David G; Barrett, Perry; Delagrange, Philippe; Boutin, Jean A

    2008-05-15

    In order to interpret the effects of melatonin ligands in rats, we need to determine their activity at the receptor subtype level in the corresponding species. Thus, the rat melatonin rMT(1) receptor was cloned using DNA fragments for exon 1 and 2 amplified from rat genomic DNA followed by screening of a rat genomic library for the full length exon sequences. The rat rMT(2) receptor subtype was cloned in a similar manner with the exception of exon 1 which was identified by screening a rat genomic library with exon 1 of the human hMT(2) receptor. The coding region of these receptors translates proteins of 353 and 364 amino acids, respectively, for rMT(1) and rMT(2). A 55% homology was observed between both rat isoforms. The entire contiguous rat MT(1) and MT(2) receptor coding sequences were cloned, stably expressed in CHO cells and characterized in binding assay using 2-[(125)I]-Iodomelatonin. The dissociation constants (K(d)) for rMT(1) and rMT(2) were 42 and 130 pM, respectively. Chemically diverse compounds previously characterized at human MT(1) and MT(2) receptors were evaluated at rMT(1) and rMT(2) receptors, for their binding affinity and functionality in [(35)S]-GTPgammaS binding assay. Some, but not all, compounds shared a similar binding affinity and functionality at both rat and human corresponding subtypes. A different pharmacological profile of the MT(1) subtype has also been observed previously between human and ovine species. These in vitro results obtained with the rat melatonin receptors are thus of importance to understand the physiological roles of each subtype in animal models.

  2. MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential.

    PubMed

    Zlotos, Darius P; Jockers, Ralf; Cecon, Erika; Rivara, Silvia; Witt-Enderby, Paula A

    2014-04-24

    Numerous physiological functions of the pineal gland hormone melatonin are mediated via activation of two G-protein-coupled receptors, MT1 and MT2. The melatonergic drugs on the market, ramelteon and agomelatine, as well as the most advanced drug candidates under clinical evaluation, tasimelteon and TIK-301, are high-affinity nonselective MT1/MT2 agonists. A great number of MT2-selective ligands and, more recently, several MT1-selective agents have been reported to date. Herein, we review recent advances in the field focusing on high-affinity agonists and antagonists and those displaying selectivity toward MT1 and MT2 receptors. Moreover, the existing models of MT1 and MT2 receptors as well as the current status in the emerging field of melatonin receptor oligomerization are critically discussed. In addition to the already existing indications, such as insomnia, circadian sleep disorders, and depression, new potential therapeutic applications of melatonergic ligands including cardiovascular regulation, appetite control, tumor growth inhibition, and neurodegenerative diseases are presented.

  3. Activation of MT(2) melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock.

    PubMed

    Hunt, A E; Al-Ghoul, W M; Gillette, M U; Dubocovich, M L

    2001-01-01

    The aim of this study was to identify the melatonin receptor type(s) (MT(1) or MT(2)) mediating circadian clock resetting by melatonin in the mammalian suprachiasmatic nucleus (SCN). Quantitative receptor autoradiography with 2-[(125)I]iodomelatonin and in situ hybridization histochemistry, with either (33)P- or digoxigenin-labeled antisense MT(1) and MT(2) melatonin receptor mRNA oligonucleotide probes, revealed specific expression of both melatonin receptor types in the SCN of inbred Long-Evans rats. The melatonin receptor type mediating phase advances of the circadian rhythm of neuronal firing rate in the SCN slice was assessed using competitive melatonin receptor antagonists, the MT(1)/MT(2) nonselective luzindole and the MT(2)-selective 4-phenyl-2-propionamidotetraline (4P-PDOT). Luzindole and 4P-PDOT (1 nM-1 microM) did not affect circadian phase on their own; however, they blocked both the phase advances (approximately 4 h) in the neuronal firing rate induced by melatonin (3 pM) at temporally distinct times of day [i.e., subjective dusk, circadian time (CT) 10; and dawn, CT 23], as well as the associated increases in protein kinase C activity. We conclude that melatonin mediates phase advances of the SCN circadian clock at both dusk and dawn via activation of MT(2) melatonin receptor signaling.

  4. Searches for supersymmetry using the M$_{T2}$ variable in hadronic events produced in pp collisions at 8 TeV

    SciTech Connect

    Khachatryan, V.

    2015-05-15

    Searches for supersymmetry (SUSY) are performed using a sample of hadronic events produced in 8 TeV pp collisions at the CERN LHC. The searches are based on the M$_{T2}$ variable, which is a measure of the transverse momentum imbalance in an event. The data were collected with the CMS detector and correspond to an integrated luminosity of 19.5 fb1. Two related searches are performed. The first is an inclusive search based on signal regions defined by the value of the M$_{T2}$ variable, the hadronic energy in the event, the jet multiplicity, and the number of jets identified as originating from bottom quarks. The second is a search for a mass peak corresponding to a Higgs boson decaying to a bottom quark-antiquark pair, where the Higgs boson is produced as a decay product of a SUSY particle. For both searches, the principal backgrounds are evaluated with data control samples. No significant excess over the expected number of background events is observed, and exclusion limits on various SUSY models are derived.

  5. High-yield expression in Escherichia coli of soluble human MT2A with native functions.

    PubMed

    Yang, Fang; Zhou, Min; He, Zhimin; Liu, Xiaorong; Sun, Lin; Sun, Yu; Chen, Zhuchu

    2007-05-01

    Metallothioneins (MTs) are a family of low molecular weight, cysteine rich heavy metal binding proteins with multifunction, such as metal detoxification and antioxidation, and are involved in a number of cellular processes including gene expression, apoptosis, proliferation and differentiation. However, high yield expression of human MT in Escherichia coli has not been established effectively. To produce large amounts of human MT protein at low cost, recombinant human metallothionein 2A (MT2A) protein with an N-terminal GST tag was successfully expressed at high levels in soluble form in E. coli and high purification of it was established by affinity chromatography under native conditions. The final yield was about 5mg of the recombinant MT2A per liter of bacterial culture with the purity of 97.9%. Chemical and functional characteristics analysis of the recombinant human MT2A exhibited intact metal binding ability, hydroxyl radical scavenging ability and significant protective role against DNA damage caused by UVC radiation. Establishment of highly purified recombinant human MT2A protein with native characteristics at low cost would improve its function study and wide applications in protecting against oxidative damage and UV radiation.

  6. Effect of melatonin and analogues on corneal wound healing: involvement of Mt2 melatonin receptor.

    PubMed

    Crooke, Almudena; Guzman-Aranguez, Ana; Mediero, Aranzazu; Alarma-Estrany, Pilar; Carracedo, Gonzalo; Pelaez, Teresa; Peral, Assumpta; Pintor, Jesús

    2015-01-01

    We have investigated the effect of melatonin and its analogues on rabbit corneal epithelial wound healing. New Zealand rabbits were anaesthetised and wounds were made by placing Whatman paper discs soaked in n-heptanol on the cornea. Melatonin and analogues (all 10 nmol) were instilled. Wound diameter was measured every 2 hours by means of fluorescein application with a Topcon SL-8Z slit lamp. Melatonin antagonists (all 10 nmol) were applied 2 hours before the application of the n-heptanol-soaked disc and then every 6 hours together with melatonin. To confirm the presence of MT2 receptors in corneal epithelial cells immunohistochemistry, Western blot and RT-PCR assays in native tissue and in rabbit corneal epithelial cells were performed. The tear components were extracted then processed by HPLC to quantify melatonin in tears. Migration assays revealed that melatonin and particularly the treatment with the MT2 agonist IIK7, accelerated the rate of healing (p < 0.001). The application of the non-selective melatonin receptor antagonist luzindole and the MT2 antagonist DH97 (but not prazosin), prevented the effect of melatonin on wound healing (both p < 0.001). Immunohistochemistry, Western blot and RT-PCR assays showed the presence of MT2 melatonin receptor in corneal epithelial cells. In addition, we have identified melatonin in tears and determined its daily variations. These data suggest that MT2 receptors are implicated in the effect of melatonin on corneal wound healing regulating migration rate. This suggests the potential use of melatonin and its analogues to enhance epithelial wound healing in ocular surface disease.

  7. Superpartner mass measurement technique using 1D orthogonal decompositions of the Cambridge transverse mass variable M(T2).

    PubMed

    Konar, Partha; Kong, Kyoungchul; Matchev, Konstantin T; Park, Myeonghun

    2010-07-30

    We propose a new model-independent technique for mass measurements in missing energy events at hadron colliders. We illustrate our method with the most challenging case of a single-step decay chain. We consider inclusive same-sign chargino pair production in supersymmetry, followed by leptonic decays to sneutrinos χ+ χ+ → ℓ+ ℓ'+ ν(ℓ)ν(ℓ') and invisible decays ν(ℓ) → ν(ℓ) χ(1)(0). We introduce two one-dimensional decompositions of the Cambridge MT2 variable: M(T2∥) and M(T2⊥), on the direction of the upstream transverse momentum P→T and the direction orthogonal to it, respectively. We show that the sneutrino mass Mc can be measured directly by minimizing the number of events N(Mc) in which MT2 exceeds a certain threshold, conveniently measured from the end point M(T2⊥)(max) (Mc).

  8. Melatonin MT1 and MT2 Receptors in the Ram Reproductive Tract

    PubMed Central

    González-Arto, Marta; Aguilar, David; Gaspar-Torrubia, Elena; Gallego, Margarita; Carvajal-Serna, Melissa; Herrera-Marcos, Luis V.; Serrano-Blesa, Edith; Hamilton, Thais Rose dos Santos; Pérez-Pé, Rosaura; Muiño-Blanco, Teresa; Cebrián-Pérez, José A.; Casao, Adriana

    2017-01-01

    Some melatonin functions in mammals are exerted through MT1 and MT2 receptors. However, there are no reports of their presence in the reproductive tract of the ram, a seasonal species. Thus, we have investigated their existence in the ram testis, epididymis, accessory glands and ductus deferens. Real-time polymerase chain reaction (qPCR) revealed higher levels of m-RNA for both receptors in the testis, ampulla, seminal vesicles, and vas deferens, than in the other organs of the reproductive tract (p < 0.05). Western blot analyses showed protein bands compatible with the MT1 in the testis and cauda epididymis, and for the MT2 in the cauda epididymis and deferent duct. Immunohistochemistry analyses revealed the presence of MT1 receptors in spermatogonias, spermatocytes, and spermatids, and MT2 receptors in the newly-formed spermatozoa in the testis, whereas both receptors were located in the epithelial cells of the ampulla, seminal vesicles, and ductus deferens. Indirect immunofluorescence showed significant differences in the immunolocation of both receptors in spermatozoa during their transit in the epididymis. In conclusion, it was demonstrated that melatonin receptors are present in the ram reproductive tract. These results open the way for new studies on the molecular mechanism of melatonin and the biological significance of its receptors. PMID:28335493

  9. [Involvement of melatonin MT2 receptor mutants in type 2 diabetes development].

    PubMed

    Karamitri, Angeliki; Vincens, Monique; Chen, Min; Jockers, Ralf

    2013-01-01

    Genetic and environmental factors participate in the development of type 2 diabetes (T2D). Genome-wide association studies have revealed new genetic variants associated with T2D, including the rs10830963 variant located in the intron of the MTNR1B gene. This gene encodes the melatonin MT2 receptor, a member of the family of G protein-coupled receptors involved in the regulation of circadian and seasonal rhythms. This surprising result stimulated new investigations in the field of T2D to better understand the role of MT2 receptors and circadian rhythms in this emerging disease. The current article intends to cover this issue starting from the discovery of the first MTNR1B gene variants until the establishment of a functional link between MTNR1B variants and the risk of developing T2D and finishes by proposing some hypotheses that might potentially explain the importance of impaired MT2 function in T2D development.

  10. Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology.

    PubMed

    Comai, Stefano; Gobbi, Gabriella

    2014-01-01

    Melatonin (MLT) is a pleiotropic neurohormone controlling many physiological processes and whose dysfunction may contribute to several different diseases, such as neurodegenerative diseases, circadian and mood disorders, insomnia, type 2 diabetes and pain. Melatonin is synthesized by the pineal gland during the night and acts through 2 G-protein coupled receptors (GPCRs), MT1 (MEL1a) and MT2 (MEL1b). Although a bulk of research has examined the physiopathological effects of MLT, few studies have investigated the selective role played by MT1 and MT2 receptors. Here we have reviewed current knowledge about the implications of MT2 receptors in brain functions. We searched PubMed, Web of Science, Scopus, Google Scholar and articles' reference lists for studies on MT2 receptor ligands in sleep, anxiety, neuropsychiatric diseases and psychopharmacology, including genetic studies on the MTNR1B gene, which encodes the melatonin MT2 receptor. These studies demonstrate that MT2 receptors are involved in the pathophysiology and pharmacology of sleep disorders, anxiety, depression, Alzheimer disease and pain and that selective MT2 receptor agonists show hypnotic and anxiolytic properties. Studies examining the role of MT2 receptors in psychopharmacology are still limited. The development of novel selective MT2 receptor ligands, together with further preclinical in vivo studies, may clarify the role of this receptor in brain function and psychopharmacology. The superfamily of GPCRs has proven to be among the most successful drug targets and, consequently, MT2 receptors have great potential for pioneer drug discovery in the treatment of mental diseases for which limited therapeutic targets are currently available.

  11. Minireview: Toward the Establishment of a Link between Melatonin and Glucose Homeostasis: Association of Melatonin MT2 Receptor Variants with Type 2 Diabetes

    PubMed Central

    Karamitri, Angeliki; Renault, Nicolas; Clement, Nathalie; Guillaume, Jean-Luc

    2013-01-01

    The existence of interindividual variations in G protein-coupled receptor sequences has been recognized early on. Recent advances in large-scale exon sequencing techniques are expected to dramatically increase the number of variants identified in G protein-coupled receptors, giving rise to new challenges regarding their functional characterization. The current minireview will illustrate these challenges based on the MTNR1B gene, which encodes the melatonin MT2 receptor, for which exon sequencing revealed 40 rare nonsynonymous variants in the general population and in type 2 diabetes (T2D) cohorts. Functional characterization of these MT2 mutants revealed 14 mutants with loss of Gi protein activation that associate with increased risk of T2D development. This repertoire of disease-associated mutants is a rich source for structure-activity studies and will help to define the still poorly understood role of melatonin in glucose homeostasis and T2D development in humans. Defining the functional defects in carriers of rare MT2 mutations will help to provide personalized therapies to these patients in the future. PMID:23798576

  12. Minireview: Toward the establishment of a link between melatonin and glucose homeostasis: association of melatonin MT2 receptor variants with type 2 diabetes.

    PubMed

    Karamitri, Angeliki; Renault, Nicolas; Clement, Nathalie; Guillaume, Jean-Luc; Jockers, Ralf

    2013-08-01

    The existence of interindividual variations in G protein-coupled receptor sequences has been recognized early on. Recent advances in large-scale exon sequencing techniques are expected to dramatically increase the number of variants identified in G protein-coupled receptors, giving rise to new challenges regarding their functional characterization. The current minireview will illustrate these challenges based on the MTNR1B gene, which encodes the melatonin MT2 receptor, for which exon sequencing revealed 40 rare nonsynonymous variants in the general population and in type 2 diabetes (T2D) cohorts. Functional characterization of these MT2 mutants revealed 14 mutants with loss of Gi protein activation that associate with increased risk of T2D development. This repertoire of disease-associated mutants is a rich source for structure-activity studies and will help to define the still poorly understood role of melatonin in glucose homeostasis and T2D development in humans. Defining the functional defects in carriers of rare MT2 mutations will help to provide personalized therapies to these patients in the future.

  13. Melatonin Suppresses Neuropathic Pain via MT2-Dependent and -Independent Pathways in Dorsal Root Ganglia Neurons of Mice

    PubMed Central

    Lin, Jia-Ji; Lin, Ye; Zhao, Tian-Zhi; Zhang, Chun-Kui; Zhang, Ting; Chen, Xiao-Li; Ding, Jia-Qi; Chang, Ting; Zhang, Zhuo; Sun, Chao; Zhao, Dai-Di; Zhu, Jun-Lin; Li, Zhu-Yi; Li, Jin-Lian

    2017-01-01

    Melatonin (Mel) and its receptors (MT1 and MT2) have a well-documented efficacy in treating different pain conditions. However, the anti-nociceptive effects of Mel and Mel receptors in neuropathic pain (NP) are poorly understood. To elucidate this process, pain behaviors were measured in a dorsal root ganglia (DRG)-friendly sciatic nerve cuffing model. We detected up-regulation of MT2 expression in the DRGs of cuff-implanted mice and its activation by the agonist 8-M-PDOT (8MP). Also, Mel attenuated the mechanical and thermal allodynia induced by cuff implantation. Immunohistochemical analysis demonstrated the expression of MT2 in the DRG neurons, while MT1 was expressed in the satellite cells. In cultured primary neurons, microarray analysis and gene knockdown experiments demonstrated that MT2 activation by 8MP or Mel suppressed calcium signaling pathways via MAPK1, which were blocked by RAR-related orphan receptor alpha (RORα) activation with a high dose of Mel. Furthermore, expression of nitric oxide synthase 1 (NOS1) was down-regulated upon Mel treatment regardless of MT2 or RORα. Application of Mel or 8MP in cuff-implanted models inhibited the activation of peptidergic neurons and neuro-inflammation in the DRGs by down-regulating c-fos, calcitonin gene-related peptide [CGRP], and tumor necrosis factor-1α [TNF-1α] and interleukin-1β [IL-1β]. Addition of the MT2 antagonist luzindole blocked the effects of 8MP but not those of Mel. In conclusion, only MT2 was expressed in the DRG neurons and up-regulated upon cuff implantation. The analgesic effects of Mel in cuff-implanted mice were closely associated with both MT2-dependent (MAPK-calcium channels) and MT2-independent (NOS1) pathways in the DRG. PMID:28656058

  14. LHC Computing

    SciTech Connect

    Lincoln, Don

    2015-07-28

    The LHC is the world’s highest energy particle accelerator and scientists use it to record an unprecedented amount of data. This data is recorded in electronic format and it requires an enormous computational infrastructure to convert the raw data into conclusions about the fundamental rules that govern matter. In this video, Fermilab’s Dr. Don Lincoln gives us a sense of just how much data is involved and the incredible computer resources that makes it all possible.

  15. Bacillus rubiinfantis sp. nov. strain mt2T, a new bacterial species isolated from human gut

    PubMed Central

    Tidjiani Alou, M.; Rathored, J.; Khelaifia, S.; Michelle, C.; Brah, S.; Diallo, B.A.; Raoult, D.; Lagier, J.-C.

    2015-01-01

    Bacillus rubiinfantis sp. nov. strain mt2T is the type strain of B. rubiinfantis sp. nov., isolated from the fecal flora of a child with kwashiorkor in Niger. It is Gram-positive facultative anaerobic rod belonging to the Bacillaceae family. We describe the features of this organism alongside the complete genome sequence and annotation. The 4 311 083 bp long genome (one chromosome but no plasmid) contains 4028 protein-coding gene and 121 RNA genes including nine rRNA genes. PMID:27076912

  16. New Radioligands for Describing the Molecular Pharmacology of MT1 and MT2 Melatonin Receptors

    PubMed Central

    Legros, Céline; Matthey, Ulrich; Grelak, Teresa; Pedragona-Moreau, Sandrine; Hassler, Werner; Yous, Saïd; Thomas, Emmanuel; Suzenet, Franck; Folleas, Benoît; Lefoulon, François; Berthelot, Pascal; Caignard, Daniel-Henri; Guillaumet, Gérald; Delagrange, Philippe; Brayer, Jean-Louis; Nosjean, Olivier; Boutin, Jean A.

    2013-01-01

    Melatonin receptors have been studied for several decades. The low expression of the receptors in tissues led the scientific community to find a substitute for the natural hormone melatonin, the agonist 2-[125I]-iodomelatonin. Using the agonist, several hundreds of studies were conducted, including the discovery of agonists and antagonists for the receptors and minute details about their molecular behavior. Recently, we attempted to expand the panel of radioligands available for studying the melatonin receptors by using the newly discovered compounds SD6, DIV880, and S70254. These compounds were characterized for their affinities to the hMT1 and hMT2 recombinant receptors and their functionality in the classical GTPγS system. SD6 is a full agonist, equilibrated between the receptor isoforms, whereas S70254 and DIV880 are only partial MT2 agonists, with Ki in the low nanomolar range while they have no affinity to MT1 receptors. These new tools will hopefully allow for additions to the current body of information on the native localization of the receptor isoforms in tissues. PMID:23698757

  17. New radioligands for describing the molecular pharmacology of MT1 and MT2 melatonin receptors.

    PubMed

    Legros, Céline; Matthey, Ulrich; Grelak, Teresa; Pedragona-Moreau, Sandrine; Hassler, Werner; Yous, Saïd; Thomas, Emmanuel; Suzenet, Franck; Folleas, Benoît; Lefoulon, François; Berthelot, Pascal; Caignard, Daniel-Henri; Guillaumet, Gérald; Delagrange, Philippe; Brayer, Jean-Louis; Nosjean, Olivier; Boutin, Jean A

    2013-04-25

    Melatonin receptors have been studied for several decades. The low expression of the receptors in tissues led the scientific community to find a substitute for the natural hormone melatonin, the agonist 2-[125I]-iodomelatonin. Using the agonist, several hundreds of studies were conducted, including the discovery of agonists and antagonists for the receptors and minute details about their molecular behavior. Recently, we attempted to expand the panel of radioligands available for studying the melatonin receptors by using the newly discovered compounds SD6, DIV880, and S70254. These compounds were characterized for their affinities to the hMT1 and hMT2 recombinant receptors and their functionality in the classical GTPS system. SD6 is a full agonist, equilibrated between the receptor isoforms, whereas S70254 and DIV880 are only partial MT2 agonists, with Ki in the low nanomolar range while they have no affinity to MT1 receptors. These new tools will hopefully allow for additions to the current body of information on the native localization of the receptor isoforms in tissues.

  18. Abnormal Skeletal Growth in Adolescent Idiopathic Scoliosis Is Associated with Abnormal Quantitative Expression of Melatonin Receptor, MT2

    PubMed Central

    Yim, Annie Po-yee; Yeung, Hiu-yan; Sun, Guangquan; Lee, Kwong-man; Ng, Tzi-bun; Lam, Tsz-ping; Ng, Bobby Kin-wah; Qiu, Yong; Moreau, Alain; Cheng, Jack Chun-yiu

    2013-01-01

    The defect of the melatonin signaling pathway has been proposed to be one of the key etiopathogenic factors in adolescent idiopathic scoliosis (AIS). A previous report showed that melatonin receptor, MT2, was undetectable in some AIS girls. The present study aimed to investigate whether the abnormal MT2 expression in AIS is quantitative or qualitative. Cultured osteoblasts were obtained from 41 AIS girls and nine normal controls. Semi-quantification of protein expression by Western blot and mRNA expression by TaqMan real-time PCR for both MT1 and MT2 were performed. Anthropometric parameters were also compared and correlated with the protein expression and mRNA expression of the receptors. The results showed significantly lower protein and mRNA expression of MT2 in AIS girls compared with that in normal controls (p = 0.02 and p = 0.019, respectively). No differences were found in the expression of MT1. When dichotomizing the AIS girls according to their MT2 expression, the group with low expression was found to have a significantly longer arm span (p = 0.036). The results of this study showed for the first time a quantitative change of MT2 in AIS that was also correlated with abnormal arm span as part of abnormal systemic skeletal growth. PMID:23519105

  19. LHC Computing

    ScienceCinema

    Lincoln, Don

    2016-07-12

    The LHC is the world’s highest energy particle accelerator and scientists use it to record an unprecedented amount of data. This data is recorded in electronic format and it requires an enormous computational infrastructure to convert the raw data into conclusions about the fundamental rules that govern matter. In this video, Fermilab’s Dr. Don Lincoln gives us a sense of just how much data is involved and the incredible computer resources that makes it all possible.

  20. Expression of mt2 and smt-B upon cadmium exposure and cold shock in zebrafish (Danio rerio).

    PubMed

    Wu, Su Mei; Zheng, Yu Da; Kuo, Chien-Hsien

    2008-08-01

    Metallothionein-2 (mt2) and similar to metallothionein-B (smt-B) are included in the MT gene family. The objective of this study was to compare mt2 and smt-B messenger (m)RNA expressions after cadmium exposure and cold shock with whole-mount in situ hybridization in immature zebrafish (Danio rerio) and with a semi-quantitative RT-PCR in mature zebrafish. Three-day post-fertilization (dpf) larvae were treated with 0, 0.08, 0.26, and 0.89 microM cadmium for 24 and 48 h, and some larvae were challenged with a normal (28.5 degrees C) or low temperature (12 degrees C) for 12, 24, and 48 h. Results were obtained. (1) During embryonic and larval development, mt2 mRNA existed at 6 h post-fertilization (hpf), and the level rapidly increased to 24 hpf, then it gradually increased with further larval growth. smt-B was found at 12 hpf, and it also rapidly increased to 24 hpf, but remained constant during further larval development. (2) The mt2 mRNA signals and whole-body Cd contents displayed dose- and time-dependent responses after Cd exposure. After cold shock, mt2 mRNA signals also showed time-dependent expression. But smt-B mRNA signals were not appeared by either challenge. Besides, mature zebrafish were treated with 1.78 microM Cd and found that the highest levels of smt-B mRNA (smt-B/beta-actin) appeared in brain, and seems a reverse expression between smt-B mRNA and mt2 in brain after Cd exposure. Apparently, mt2 is possibly more relevant to Cd detoxification and cold shock adaptation in zebrafish larvae compared to smt-B, but smt-B might be related to certain physiological functions in neural (or brain) of mature zebrafish.

  1. Effects of the Melatonin MT-1/MT-2 Agonist Ramelteon on Daytime Body Temperature and Sleep

    PubMed Central

    Markwald, Rachel R.; Lee-Chiong, Teofilo L.; Burke, Tina M.; Snider, Jesse A.; Wright, Kenneth P.

    2010-01-01

    Study Objectives: A reduction in core temperature and an increase in the distal-proximal skin gradient (DPG) are reported to be associated with shorter sleep onset latencies (SOL) and better sleep quality. Ramelteon is a melatonin MT-1/MT-2 agonist approved for the treatment of insomnia. At night, ramelteon has been reported to shorten SOL. In the present study we tested the hypothesis that ramelteon would reduce core temperature, increase the DPG, as well as shorten SOL, reduce wakefulness after sleep onset (WASO), and increase total sleep time (TST) during a daytime sleep opportunity. Design: Randomized, double-blind, placebo-controlled, cross-over design. Eight mg ramelteon or placebo was administered 2 h prior to a 4-h daytime sleep opportunity. Setting: Sleep and chronobiology laboratory. Participants: Fourteen healthy adults (5 females), aged (23.2 ± 4.2 y). Measurements and Results: Primary outcome measures included core body temperature, the DPG and sleep physiology (minutes of total sleep time [TST], wake after sleep onset [WASO], and SOL). We also assessed as secondary outcomes, proximal and distal skin temperatures, sleep staging and subjective TST. Repeated measures ANOVA revealed ramelteon significantly reduced core temperature and increased the DPG (both P < 0.05). Furthermore, ramelteon reduced WASO and increased TST, and stages 1 and 2 sleep (all P < 0.05). The change in the DPG was negatively correlated with SOL in the ramelteon condition. Conclusions: Ramelteon improved daytime sleep, perhaps mechanistically in part by reducing core temperature and modulating skin temperature. These findings suggest that ramelteon may have promise for the treatment of insomnia associated with circadian misalignment due to circadian sleep disorders. Citation: Markwald RR; Lee-Choing TL; Burke TM; Snider JA; Wright KP. Effects of the melatonin MT-1/MT-2 agonist ramelteon on daytime body temperature and sleep. SLEEP 2010;33(6):825-831 PMID:20550024

  2. Searches for supersymmetry using the M$$_{T2}$$ variable in hadronic events produced in pp collisions at 8 TeV

    DOE PAGES

    Khachatryan, V.

    2015-05-15

    Searches for supersymmetry (SUSY) are performed using a sample of hadronic events produced in 8 TeV pp collisions at the CERN LHC. The searches are based on the Mmore » $$_{T2}$$ variable, which is a measure of the transverse momentum imbalance in an event. The data were collected with the CMS detector and correspond to an integrated luminosity of 19.5 fb1. Two related searches are performed. The first is an inclusive search based on signal regions defined by the value of the M$$_{T2}$$ variable, the hadronic energy in the event, the jet multiplicity, and the number of jets identified as originating from bottom quarks. The second is a search for a mass peak corresponding to a Higgs boson decaying to a bottom quark-antiquark pair, where the Higgs boson is produced as a decay product of a SUSY particle. For both searches, the principal backgrounds are evaluated with data control samples. No significant excess over the expected number of background events is observed, and exclusion limits on various SUSY models are derived.« less

  3. Search for new physics with the MT2 variable in all-jets final states produced in pp collisions at $$ \\sqrt{s}=13 $$ TeV

    DOE PAGES

    Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; ...

    2016-10-03

    A search for new physics is performed using events that contain one or more jets, no isolated leptons, and a large transverse momentum imbalance, as measured through the MT2 variable, which is an extension of the transverse mass in events with two invisible particles. The results are based on a sample of proton-proton collisions collected at a center-of-mass energy of 13 TeV with the CMS detector at the LHC, and that corresponds to an integrated luminosity of 2.3 fb–1. The observed event yields in the data are consistent with predictions for the standard model backgrounds. The results are interpreted usingmore » simplified models of supersymmetry and are expressed in terms of limits on the masses of potential new colored particles. Assuming that the lightest neutralino is stable and has a mass less than about 500 GeV, gluino masses up to 1550-1750 GeV are excluded at 95% confidence level, depending on the gluino decay mechanism. For the scenario of direct production of squark-antisquark pairs, top squarks with masses up to 800 GeV are excluded, assuming a 100% branching fraction for the decay to a top quark and neutralino. Moreover, bottom squark masses are excluded up to 880 GeV, and masses of light-flavor squarks are excluded up to 600-1260 GeV, depending on the degree of degeneracy of the squark masses.« less

  4. The diversity of the structure and genomic integration sites of HTLV-1 provirus in MT-2 cell lines.

    PubMed

    Hashikura, Yuuki; Umeki, Kazumi; Umekita, Kunihiko; Nomura, Hajime; Yamamoto, Ikuo; Hasegawa, Hiroo; Yanagihara, Katsunori; Okayama, Akihiko

    2016-07-01

    A human T-lymphotropic virus Type 1 (HTLV-1) positive cell line, MT-2, derived from human cord leukocytes co-culturing with adult T cell leukemia/lymphoma (ATL) cells is commonly used in HTLV-1 research; however, the details of provirus integrated in MT-2 genome have not yet been characterized. In this study, five types of HTLV-1 proviral sequences were detected in 11 different sites of the genome in a reference MT-2 cell line. The five types of HTLV-1 proviral sequences were one complete proviral genome, two types of proviruses with deletion of large internal viral sequences (5.3 and 3.9 kB), one provirus with a large deletion (6.2 kB) from 5'LTR to position 6257, and one provirus of LTR only. The provirus with identical deletion of large internal viral sequence (5.3 kB) was found to be integrated into six different sites (chromosomes). A complete provirus and three of four types of defective provirus were consistently detected in two other MT-2 cell lines cultured in different laboratories. Not only Tax/Rex RNA and HBZ RNA, but also the transcriptional product for a specific defective provirus, were detectable in all three MT-2 cell lines. Because it has been reported that defective provirus is frequently detected in ATL cells, these results may be important in understanding the mechanism of HTLV-1 proviral polymorphism, which may be related to leukemogenesis. In addition, the large variation in integrated HTLV-1 proviruses makes it important for researchers to exercise caution in their assessment and interpretation of results using MT-2 cell lines.

  5. Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors

    PubMed Central

    Renzi, Anastasia; Glaser, Shannon; DeMorrow, Sharon; Mancinelli, Romina; Meng, Fanyin; Franchitto, Antonio; Venter, Julie; White, Mellanie; Francis, Heather; Han, Yuyan; Alvaro, Domenico; Gaudio, Eugenio; Carpino, Guido; Ueno, Yoshiyuki; Onori, Paolo

    2011-01-01

    In bile duct-ligated (BDL) rats, large cholangiocytes proliferate by activation of cAMP-dependent signaling. Melatonin, which is secreted from pineal gland as well as extrapineal tissues, regulates cell mitosis by interacting with melatonin receptors (MT1 and MT2) modulating cAMP and clock genes. In the liver, melatonin suppresses oxidative damage and ameliorates fibrosis. No information exists regarding the role of melatonin in the regulation of biliary hyperplasia. We evaluated the mechanisms of action by which melatonin regulates the growth of cholangiocytes. In normal and BDL rats, we determined the hepatic distribution of MT1, MT2, and the clock genes, CLOCK, BMAL1, CRY1, and PER1. Normal and BDL (immediately after BDL) rats were treated in vivo with melatonin before evaluating 1) serum levels of melatonin, bilirubin, and transaminases; 2) intrahepatic bile duct mass (IBDM) in liver sections; and 3) the expression of MT1 and MT2, clock genes, and PKA phosphorylation. In vitro, large cholangiocytes were stimulated with melatonin in the absence/presence of luzindole (MT1/MT2 antagonist) and 4-phenyl-2-propionamidotetralin (MT2 antagonist) before evaluating cell proliferation, cAMP levels, and PKA phosphorylation. Cholangiocytes express MT1 and MT2, CLOCK, BMAL1, CRY1, and PER1 that were all upregulated following BDL. Administration of melatonin to BDL rats decreased IBDM, serum bilirubin and transaminases levels, the expression of all clock genes, cAMP levels, and PKA phosphorylation in cholangiocytes. In vitro, melatonin decreased the proliferation, cAMP levels, and PKA phosphorylation, decreases that were blocked by luzindole. Melatonin may be important in the management of biliary hyperplasia in human cholangiopathies. PMID:21757639

  6. Measurement of the top quark mass in the dileptonic t t ¯ decay channel using the mass observables Mb ℓ , MT 2 , and Mb ℓν in pp collisions at √{s }=8 TeV

    NASA Astrophysics Data System (ADS)

    Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Asilar, E.; Bergauer, T.; Brandstetter, J.; Brondolin, E.; Dragicevic, M.; Erö, J.; Flechl, M.; Friedl, M.; Frühwirth, R.; Ghete, V. M.; Hartl, C.; Hörmann, N.; Hrubec, J.; Jeitler, M.; König, A.; Krätschmer, I.; Liko, D.; Matsushita, T.; Mikulec, I.; Rabady, D.; Rad, N.; Rahbaran, B.; Rohringer, H.; Schieck, J.; Strauss, J.; Waltenberger, W.; Wulz, C.-E.; Dvornikov, O.; Makarenko, V.; Mossolov, V.; Suarez Gonzalez, J.; Zykunov, V.; Shumeiko, N.; Alderweireldt, S.; De Wolf, E. A.; Janssen, X.; Lauwers, J.; Van De Klundert, M.; Van Haevermaet, H.; Van Mechelen, P.; Van Remortel, N.; Van Spilbeeck, A.; Abu Zeid, S.; Blekman, F.; D'Hondt, J.; Daci, N.; De Bruyn, I.; Deroover, K.; Lowette, S.; Moortgat, S.; Moreels, L.; Olbrechts, A.; Python, Q.; Skovpen, K.; Tavernier, S.; Van Doninck, W.; Van Mulders, P.; Van Parijs, I.; Brun, H.; Clerbaux, B.; De Lentdecker, G.; Delannoy, H.; Fasanella, G.; Favart, L.; Goldouzian, R.; Grebenyuk, A.; Karapostoli, G.; Lenzi, T.; Léonard, A.; Luetic, J.; Maerschalk, T.; Marinov, A.; Randle-conde, A.; Seva, T.; Vander Velde, C.; Vanlaer, P.; Vannerom, D.; Yonamine, R.; Zenoni, F.; Zhang, F.; Cornelis, T.; Dobur, D.; Fagot, A.; Gul, M.; Khvastunov, I.; Poyraz, D.; Salva, S.; Schöfbeck, R.; Tytgat, M.; Van Driessche, W.; Yazgan, E.; Zaganidis, N.; Bakhshiansohi, H.; Bondu, O.; Brochet, S.; Bruno, G.; Caudron, A.; De Visscher, S.; Delaere, C.; Delcourt, M.; Francois, B.; Giammanco, A.; Jafari, A.; Komm, M.; Krintiras, G.; Lemaitre, V.; Magitteri, A.; Mertens, A.; Musich, M.; Piotrzkowski, K.; Quertenmont, L.; Selvaggi, M.; Vidal Marono, M.; Wertz, S.; Beliy, N.; Aldá Júnior, W. L.; Alves, F. L.; Alves, G. A.; Brito, L.; Hensel, C.; Moraes, A.; Pol, M. E.; Rebello Teles, P.; Belchior Batista Das Chagas, E.; Carvalho, W.; Chinellato, J.; Custódio, A.; Da Costa, E. M.; Da Silveira, G. G.; De Jesus Damiao, D.; De Oliveira Martins, C.; Fonseca De Souza, S.; Huertas Guativa, L. M.; Malbouisson, H.; Matos Figueiredo, D.; Mora Herrera, C.; Mundim, L.; Nogima, H.; Prado Da Silva, W. L.; Santoro, A.; Sznajder, A.; Tonelli Manganote, E. J.; Torres Da Silva De Araujo, F.; Vilela Pereira, A.; Ahuja, S.; Bernardes, C. A.; Dogra, S.; Fernandez Perez Tomei, T. R.; Gregores, E. M.; Mercadante, P. G.; Moon, C. S.; Novaes, S. F.; Padula, Sandra S.; Romero Abad, D.; Ruiz Vargas, J. C.; Aleksandrov, A.; Hadjiiska, R.; Iaydjiev, P.; Rodozov, M.; Stoykova, S.; Sultanov, G.; Vutova, M.; Dimitrov, A.; Glushkov, I.; Litov, L.; Pavlov, B.; Petkov, P.; Fang, W.; Ahmad, M.; Bian, J. G.; Chen, G. M.; Chen, H. S.; Chen, M.; Chen, Y.; Cheng, T.; Jiang, C. H.; Leggat, D.; Liu, Z.; Romeo, F.; Ruan, M.; Shaheen, S. M.; Spiezia, A.; Tao, J.; Wang, C.; Wang, Z.; Zhang, H.; Zhao, J.; Ban, Y.; Chen, G.; Li, Q.; Liu, S.; Mao, Y.; Qian, S. J.; Wang, D.; Xu, Z.; Avila, C.; Cabrera, A.; Chaparro Sierra, L. F.; Florez, C.; Gomez, J. P.; González Hernández, C. F.; Ruiz Alvarez, J. D.; Sanabria, J. C.; Godinovic, N.; Lelas, D.; Puljak, I.; Ribeiro Cipriano, P. M.; Sculac, T.; Antunovic, Z.; Kovac, M.; Brigljevic, V.; Ferencek, D.; Kadija, K.; Mesic, B.; Susa, T.; Ather, M. W.; Attikis, A.; Mavromanolakis, G.; Mousa, J.; Nicolaou, C.; Ptochos, F.; Razis, P. A.; Rykaczewski, H.; Finger, M.; Finger, M.; Carrera Jarrin, E.; Assran, Y.; Elkafrawy, T.; Mahrous, A.; Kadastik, M.; Perrini, L.; Raidal, M.; Tiko, A.; Veelken, C.; Eerola, P.; Pekkanen, J.; Voutilainen, M.; Härkönen, J.; Järvinen, T.; Karimäki, V.; Kinnunen, R.; Lampén, T.; Lassila-Perini, K.; Lehti, S.; Lindén, T.; Luukka, P.; Tuominiemi, J.; Tuovinen, E.; Wendland, L.; Talvitie, J.; Tuuva, T.; Besancon, M.; Couderc, F.; Dejardin, M.; Denegri, D.; Fabbro, B.; Faure, J. L.; Favaro, C.; Ferri, F.; Ganjour, S.; Ghosh, S.; Givernaud, A.; Gras, P.; Hamel de Monchenault, G.; Jarry, P.; Kucher, I.; Locci, E.; Machet, M.; Malcles, J.; Rander, J.; Rosowsky, A.; Titov, M.; Abdulsalam, A.; Antropov, I.; Baffioni, S.; Beaudette, F.; Busson, P.; Cadamuro, L.; Chapon, E.; Charlot, C.; Davignon, O.; Granier de Cassagnac, R.; Jo, M.; Lisniak, S.; Miné, P.; Nguyen, M.; Ochando, C.; Ortona, G.; Paganini, P.; Pigard, P.; Regnard, S.; Salerno, R.; Sirois, Y.; Stahl Leiton, A. G.; Strebler, T.; Yilmaz, Y.; Zabi, A.; Zghiche, A.; Agram, J.-L.; Andrea, J.; Bloch, D.; Brom, J.-M.; Buttignol, M.; Chabert, E. C.; Chanon, N.; Collard, C.; Conte, E.; Coubez, X.; Fontaine, J.-C.; Gelé, D.; Goerlach, U.; Le Bihan, A.-C.; Van Hove, P.; Gadrat, S.; Beauceron, S.; Bernet, C.; Boudoul, G.; Carrillo Montoya, C. A.; Chierici, R.; Contardo, D.; Courbon, B.; Depasse, P.; El Mamouni, H.; Fay, J.; Finco, L.; Gascon, S.; Gouzevitch, M.; Grenier, G.; Ille, B.; Lagarde, F.; Laktineh, I. B.; Lethuillier, M.; Mirabito, L.; Pequegnot, A. L.; Perries, S.; Popov, A.; Sordini, V.; Vander Donckt, M.; Verdier, P.; Viret, S.; Khvedelidze, A.; Tsamalaidze, Z.; Autermann, C.; Beranek, S.; Feld, L.; Kiesel, M. K.; Klein, K.; Lipinski, M.; Preuten, M.; Schomakers, C.; Schulz, J.; Verlage, T.; Albert, A.; Brodski, M.; Dietz-Laursonn, E.; Duchardt, D.; Endres, M.; Erdmann, M.; Erdweg, S.; Esch, T.; Fischer, R.; Güth, A.; Hamer, M.; Hebbeker, T.; Heidemann, C.; Hoepfner, K.; Knutzen, S.; Merschmeyer, M.; Meyer, A.; Millet, P.; Mukherjee, S.; Olschewski, M.; Padeken, K.; Pook, T.; Radziej, M.; Reithler, H.; Rieger, M.; Scheuch, F.; Sonnenschein, L.; Teyssier, D.; Thüer, S.; Cherepanov, V.; Flügge, G.; Kargoll, B.; Kress, T.; Künsken, A.; Lingemann, J.; Müller, T.; Nehrkorn, A.; Nowack, A.; Pistone, C.; Pooth, O.; Stahl, A.; Aldaya Martin, M.; Arndt, T.; Asawatangtrakuldee, C.; Beernaert, K.; Behnke, O.; Behrens, U.; Bin Anuar, A. A.; Borras, K.; Campbell, A.; Connor, P.; Contreras-Campana, C.; Costanza, F.; Diez Pardos, C.; Dolinska, G.; Eckerlin, G.; Eckstein, D.; Eichhorn, T.; Eren, E.; Gallo, E.; Garay Garcia, J.; Geiser, A.; Gizhko, A.; Grados Luyando, J. M.; Grohsjean, A.; Gunnellini, P.; Harb, A.; Hauk, J.; Hempel, M.; Jung, H.; Kalogeropoulos, A.; Karacheban, O.; Kasemann, M.; Keaveney, J.; Kleinwort, C.; Korol, I.; Krücker, D.; Lange, W.; Lelek, A.; Lenz, T.; Leonard, J.; Lipka, K.; Lobanov, A.; Lohmann, W.; Mankel, R.; Melzer-Pellmann, I.-A.; Meyer, A. B.; Mittag, G.; Mnich, J.; Mussgiller, A.; Pitzl, D.; Placakyte, R.; Raspereza, A.; Roland, B.; Sahin, M. Ö.; Saxena, P.; Schoerner-Sadenius, T.; Spannagel, S.; Stefaniuk, N.; Van Onsem, G. P.; Walsh, R.; Wissing, C.; Blobel, V.; Centis Vignali, M.; Draeger, A. R.; Dreyer, T.; Garutti, E.; Gonzalez, D.; Haller, J.; Hoffmann, M.; Junkes, A.; Klanner, R.; Kogler, R.; Kovalchuk, N.; Kurz, S.; Lapsien, T.; Marchesini, I.; Marconi, D.; Meyer, M.; Niedziela, M.; Nowatschin, D.; Pantaleo, F.; Peiffer, T.; Perieanu, A.; Scharf, C.; Schleper, P.; Schmidt, A.; Schumann, S.; Schwandt, J.; Sonneveld, J.; Stadie, H.; Steinbrück, G.; Stober, F. M.; Stöver, M.; Tholen, H.; Troendle, D.; Usai, E.; Vanelderen, L.; Vanhoefer, A.; Vormwald, B.; Akbiyik, M.; Barth, C.; Baur, S.; Baus, C.; Berger, J.; Butz, E.; Caspart, R.; Chwalek, T.; Colombo, F.; De Boer, W.; Dierlamm, A.; Fink, S.; Freund, B.; Friese, R.; Giffels, M.; Gilbert, A.; Goldenzweig, P.; Haitz, D.; Hartmann, F.; Heindl, S. M.; Husemann, U.; Kassel, F.; Katkov, I.; Kudella, S.; Mildner, H.; Mozer, M. U.; Müller, Th.; Plagge, M.; Quast, G.; Rabbertz, K.; Röcker, S.; Roscher, F.; Schröder, M.; Shvetsov, I.; Sieber, G.; Simonis, H. J.; Ulrich, R.; Wayand, S.; Weber, M.; Weiler, T.; Williamson, S.; Wöhrmann, C.; Wolf, R.; Anagnostou, G.; Daskalakis, G.; Geralis, T.; Giakoumopoulou, V. A.; Kyriakis, A.; Loukas, D.; Topsis-Giotis, I.; Kesisoglou, S.; Panagiotou, A.; Saoulidou, N.; Tziaferi, E.; Kousouris, K.; Evangelou, I.; Flouris, G.; Foudas, C.; Kokkas, P.; Loukas, N.; Manthos, N.; Papadopoulos, I.; Paradas, E.; Filipovic, N.; Pasztor, G.; Bencze, G.; Hajdu, C.; Horvath, D.; Sikler, F.; Veszpremi, V.; Vesztergombi, G.; Zsigmond, A. J.; Beni, N.; Czellar, S.; Karancsi, J.; Makovec, A.; Molnar, J.; Szillasi, Z.; Bartók, M.; Raics, P.; Trocsanyi, Z. L.; Ujvari, B.; Choudhury, S.; Komaragiri, J. R.; Bahinipati, S.; Bhowmik, S.; Mal, P.; Mandal, K.; Nayak, A.; Sahoo, D. K.; Sahoo, N.; Swain, S. K.; Bansal, S.; Beri, S. B.; Bhatnagar, V.; Chawla, R.; Bhawandeep, U.; Kalsi, A. K.; Kaur, A.; Kaur, M.; Kumar, R.; Kumari, P.; Mehta, A.; Mittal, M.; Singh, J. B.; Walia, G.; Kumar, Ashok; Bhardwaj, A.; Choudhary, B. C.; Garg, R. B.; Keshri, S.; Kumar, A.; Malhotra, S.; Naimuddin, M.; Ranjan, K.; Sharma, R.; Sharma, V.; Bhattacharya, R.; Bhattacharya, S.; Chatterjee, K.; Dey, S.; Dutt, S.; Dutta, S.; Ghosh, S.; Majumdar, N.; Modak, A.; Mondal, K.; Mukhopadhyay, S.; Nandan, S.; Purohit, A.; Roy, A.; Roy, D.; Roy Chowdhury, S.; Sarkar, S.; Sharan, M.; Thakur, S.; Behera, P. K.; Chudasama, R.; Dutta, D.; Jha, V.; Kumar, V.; Mohanty, A. K.; Netrakanti, P. K.; Pant, L. M.; Shukla, P.; Topkar, A.; Aziz, T.; Dugad, S.; Kole, G.; Mahakud, B.; Mitra, S.; Mohanty, G. B.; Parida, B.; Sur, N.; Sutar, B.; Banerjee, S.; Dewanjee, R. K.; Ganguly, S.; Guchait, M.; Jain, Sa.; Kumar, S.; Maity, M.; Majumder, G.; Mazumdar, K.; Sarkar, T.; Wickramage, N.; Chauhan, S.; Dube, S.; Hegde, V.; Kapoor, A.; Kothekar, K.; Pandey, S.; Rane, A.; Sharma, S.; Chenarani, S.; Eskandari Tadavani, E.; Etesami, S. M.; Khakzad, M.; Mohammadi Najafabadi, M.; Naseri, M.; Paktinat Mehdiabadi, S.; Rezaei Hosseinabadi, F.; Safarzadeh, B.; Zeinali, M.; Felcini, M.; Grunewald, M.; Abbrescia, M.; Calabria, C.; Caputo, C.; Colaleo, A.; Creanza, D.; Cristella, L.; De Filippis, N.; De Palma, M.; Fiore, L.; Iaselli, G.; Maggi, G.; Maggi, M.; Miniello, G.; My, S.; Nuzzo, S.; Pompili, A.; Pugliese, G.; Radogna, R.; Ranieri, A.; Selvaggi, G.; Sharma, A.; Silvestris, L.; Venditti, R.; Verwilligen, P.; Abbiendi, G.; Battilana, C.; Bonacorsi, D.; Braibant-Giacomelli, S.; Brigliadori, L.; Campanini, R.; Capiluppi, P.; Castro, A.; Cavallo, F. R.; Chhibra, S. S.; Codispoti, G.; Cuffiani, M.; Dallavalle, G. M.; Fabbri, F.; Fanfani, A.; Fasanella, D.; Giacomelli, P.; Grandi, C.; Guiducci, L.; Marcellini, S.; Masetti, G.; Montanari, A.; Navarria, F. L.; Perrotta, A.; Rossi, A. M.; Rovelli, T.; Siroli, G. P.; Tosi, N.; Albergo, S.; Costa, S.; Di Mattia, A.; Giordano, F.; Potenza, R.; Tricomi, A.; Tuve, C.; Barbagli, G.; Ciulli, V.; Civinini, C.; D'Alessandro, R.; Focardi, E.; Lenzi, P.; Meschini, M.; Paoletti, S.; Russo, L.; Sguazzoni, G.; Strom, D.; Viliani, L.; Benussi, L.; Bianco, S.; Fabbri, F.; Piccolo, D.; Primavera, F.; Calvelli, V.; Ferro, F.; Monge, M. R.; Robutti, E.; Tosi, S.; Brianza, L.; Brivio, F.; Ciriolo, V.; Dinardo, M. E.; Fiorendi, S.; Gennai, S.; Ghezzi, A.; Govoni, P.; Malberti, M.; Malvezzi, S.; Manzoni, R. A.; Menasce, D.; Moroni, L.; Paganoni, M.; Pedrini, D.; Pigazzini, S.; Ragazzi, S.; Tabarelli de Fatis, T.; Buontempo, S.; Cavallo, N.; De Nardo, G.; Di Guida, S.; Esposito, M.; Fabozzi, F.; Fienga, F.; Iorio, A. O. M.; Lanza, G.; Lista, L.; Meola, S.; Paolucci, P.; Sciacca, C.; Thyssen, F.; Azzi, P.; Bacchetta, N.; Benato, L.; Bisello, D.; Boletti, A.; Carlin, R.; Checchia, P.; Dall'Osso, M.; De Castro Manzano, P.; Dorigo, T.; Dosselli, U.; Gasparini, F.; Gasparini, U.; Lacaprara, S.; Margoni, M.; Meneguzzo, A. T.; Pazzini, J.; Pozzobon, N.; Ronchese, P.; Rossin, R.; Simonetto, F.; Torassa, E.; Ventura, S.; Zanetti, M.; Zotto, P.; Zumerle, G.; Braghieri, A.; Fallavollita, F.; Magnani, A.; Montagna, P.; Ratti, S. P.; Re, V.; Ressegotti, M.; Riccardi, C.; Salvini, P.; Vai, I.; Vitulo, P.; Alunni Solestizi, L.; Bilei, G. M.; Ciangottini, D.; Fanò, L.; Lariccia, P.; Leonardi, R.; Mantovani, G.; Mariani, V.; Menichelli, M.; Saha, A.; Santocchia, A.; Androsov, K.; Azzurri, P.; Bagliesi, G.; Bernardini, J.; Boccali, T.; Castaldi, R.; Ciocci, M. A.; Dell'Orso, R.; Fedi, G.; Giassi, A.; Grippo, M. T.; Ligabue, F.; Lomtadze, T.; Martini, L.; Messineo, A.; Palla, F.; Rizzi, A.; Savoy-Navarro, A.; Spagnolo, P.; Tenchini, R.; Tonelli, G.; Venturi, A.; Verdini, P. G.; Barone, L.; Cavallari, F.; Cipriani, M.; Del Re, D.; Diemoz, M.; Gelli, S.; Longo, E.; Margaroli, F.; Marzocchi, B.; Meridiani, P.; Organtini, G.; Paramatti, R.; Preiato, F.; Rahatlou, S.; Rovelli, C.; Santanastasio, F.; Amapane, N.; Arcidiacono, R.; Argiro, S.; Arneodo, M.; Bartosik, N.; Bellan, R.; Biino, C.; Cartiglia, N.; Cenna, F.; Costa, M.; Covarelli, R.; Degano, A.; Demaria, N.; Kiani, B.; Mariotti, C.; Maselli, S.; Migliore, E.; Monaco, V.; Monteil, E.; Monteno, M.; Obertino, M. M.; Pacher, L.; Pastrone, N.; Pelliccioni, M.; Pinna Angioni, G. L.; Ravera, F.; Romero, A.; Ruspa, M.; Sacchi, R.; Shchelina, K.; Sola, V.; Solano, A.; Staiano, A.; Traczyk, P.; Belforte, S.; Casarsa, M.; Cossutti, F.; Della Ricca, G.; Zanetti, A.; Kim, D. H.; Kim, G. N.; Kim, M. S.; Lee, J.; Lee, S.; Lee, S. W.; Oh, Y. D.; Sekmen, S.; Son, D. C.; Yang, Y. C.; Lee, A.; Kim, H.; Brochero Cifuentes, J. A.; Kim, T. J.; Cho, S.; Choi, S.; Go, Y.; Gyun, D.; Ha, S.; Hong, B.; Jo, Y.; Kim, Y.; Lee, K.; Lee, K. S.; Lee, S.; Lim, J.; Park, S. K.; Roh, Y.; Almond, J.; Kim, J.; Lee, H.; Oh, S. B.; Radburn-Smith, B. C.; Seo, S. h.; Yang, U. K.; Yoo, H. D.; Yu, G. B.; Choi, M.; Kim, H.; Kim, J. H.; Lee, J. S. H.; Park, I. C.; Ryu, G.; Ryu, M. S.; Choi, Y.; Goh, J.; Hwang, C.; Lee, J.; Yu, I.; Dudenas, V.; Juodagalvis, A.; Vaitkus, J.; Ahmed, I.; Ibrahim, Z. A.; Md Ali, M. A. B.; Mohamad Idris, F.; Wan Abdullah, W. A. T.; Yusli, M. N.; Zolkapli, Z.; Castilla-Valdez, H.; De La Cruz-Burelo, E.; Heredia-De La Cruz, I.; Hernandez-Almada, A.; Lopez-Fernandez, R.; Magaña Villalba, R.; Mejia Guisao, J.; Sanchez-Hernandez, A.; Carrillo Moreno, S.; Oropeza Barrera, C.; Vazquez Valencia, F.; Carpinteyro, S.; Pedraza, I.; Salazar Ibarguen, H. A.; Uribe Estrada, C.; Morelos Pineda, A.; Krofcheck, D.; Butler, P. H.; Ahmad, A.; Ahmad, M.; Hassan, Q.; Hoorani, H. R.; Khan, W. A.; Saddique, A.; Shah, M. A.; Shoaib, M.; Waqas, M.; Bialkowska, H.; Bluj, M.; Boimska, B.; Frueboes, T.; Górski, M.; Kazana, M.; Nawrocki, K.; Romanowska-Rybinska, K.; Szleper, M.; Zalewski, P.; Bunkowski, K.; Byszuk, A.; Doroba, K.; Kalinowski, A.; Konecki, M.; Krolikowski, J.; Misiura, M.; Olszewski, M.; Pyskir, A.; Walczak, M.; Bargassa, P.; Beirão Da Cruz E Silva, C.; Calpas, B.; Di Francesco, A.; Faccioli, P.; Gallinaro, M.; Hollar, J.; Leonardo, N.; Lloret Iglesias, L.; Nemallapudi, M. V.; Seixas, J.; Toldaiev, O.; Vadruccio, D.; Varela, J.; Afanasiev, S.; Bunin, P.; Gavrilenko, M.; Golutvin, I.; Gorbunov, I.; Kamenev, A.; Karjavin, V.; Lanev, A.; Malakhov, A.; Matveev, V.; Palichik, V.; Perelygin, V.; Shmatov, S.; Shulha, S.; Skatchkov, N.; Smirnov, V.; Voytishin, N.; Zarubin, A.; Chtchipounov, L.; Golovtsov, V.; Ivanov, Y.; Kim, V.; Kuznetsova, E.; Murzin, V.; Oreshkin, V.; Sulimov, V.; Vorobyev, A.; Andreev, Yu.; Dermenev, A.; Gninenko, S.; Golubev, N.; Karneyeu, A.; Kirsanov, M.; Krasnikov, N.; Pashenkov, A.; Tlisov, D.; Toropin, A.; Epshteyn, V.; Gavrilov, V.; Lychkovskaya, N.; Popov, V.; Pozdnyakov, I.; Safronov, G.; Spiridonov, A.; Toms, M.; Vlasov, E.; Zhokin, A.; Aushev, T.; Bylinkin, A.; Chadeeva, M.; Markin, O.; Tarkovskii, E.; Andreev, V.; Azarkin, M.; Dremin, I.; Kirakosyan, M.; Leonidov, A.; Terkulov, A.; Baskakov, A.; Belyaev, A.; Boos, E.; Bunichev, V.; Dubinin, M.; Dudko, L.; Klyukhin, V.; Kodolova, O.; Korneeva, N.; Lokhtin, I.; Miagkov, I.; Obraztsov, S.; Perfilov, M.; Savrin, V.; Volkov, P.; Blinov, V.; Skovpen, Y.; Shtol, D.; Azhgirey, I.; Bayshev, I.; Bitioukov, S.; Elumakhov, D.; Kachanov, V.; Kalinin, A.; Konstantinov, D.; Krychkine, V.; Petrov, V.; Ryutin, R.; Sobol, A.; Troshin, S.; Tyurin, N.; Uzunian, A.; Volkov, A.; Adzic, P.; Cirkovic, P.; Devetak, D.; Dordevic, M.; Milosevic, J.; Rekovic, V.; Alcaraz Maestre, J.; Barrio Luna, M.; Calvo, E.; Cerrada, M.; Chamizo Llatas, M.; Colino, N.; De La Cruz, B.; Delgado Peris, A.; Escalante Del Valle, A.; Fernandez Bedoya, C.; Fernández Ramos, J. P.; Flix, J.; Fouz, M. C.; Garcia-Abia, P.; Gonzalez Lopez, O.; Goy Lopez, S.; Hernandez, J. M.; Josa, M. I.; Navarro De Martino, E.; Pérez-Calero Yzquierdo, A.; Puerta Pelayo, J.; Quintario Olmeda, A.; Redondo, I.; Romero, L.; Soares, M. S.; de Trocóniz, J. F.; Missiroli, M.; Moran, D.; Cuevas, J.; Erice, C.; Fernandez Menendez, J.; Gonzalez Caballero, I.; González Fernández, J. R.; Palencia Cortezon, E.; Sanchez Cruz, S.; Suárez Andrés, I.; Vischia, P.; Vizan Garcia, J. M.; Cabrillo, I. J.; Calderon, A.; Curras, E.; Fernandez, M.; Garcia-Ferrero, J.; Gomez, G.; Lopez Virto, A.; Marco, J.; Martinez Rivero, C.; Matorras, F.; Piedra Gomez, J.; Rodrigo, T.; Ruiz-Jimeno, A.; Scodellaro, L.; Trevisani, N.; Vila, I.; Vilar Cortabitarte, R.; Abbaneo, D.; Auffray, E.; Auzinger, G.; Baillon, P.; Ball, A. H.; Barney, D.; Bloch, P.; Bocci, A.; Botta, C.; Camporesi, T.; Castello, R.; Cepeda, M.; Cerminara, G.; Chen, Y.; Cimmino, A.; d'Enterria, D.; Dabrowski, A.; Daponte, V.; David, A.; De Gruttola, M.; De Roeck, A.; Di Marco, E.; Dobson, M.; Dorney, B.; du Pree, T.; Duggan, D.; Dünser, M.; Dupont, N.; Elliott-Peisert, A.; Everaerts, P.; Fartoukh, S.; Franzoni, G.; Fulcher, J.; Funk, W.; Gigi, D.; Gill, K.; Girone, M.; Glege, F.; Gulhan, D.; Gundacker, S.; Guthoff, M.; Harris, P.; Hegeman, J.; Innocente, V.; Janot, P.; Kieseler, J.; Kirschenmann, H.; Knünz, V.; Kornmayer, A.; Kortelainen, M. J.; Krammer, M.; Lange, C.; Lecoq, P.; Lourenço, C.; Lucchini, M. T.; Malgeri, L.; Mannelli, M.; Martelli, A.; Meijers, F.; Merlin, J. A.; Mersi, S.; Meschi, E.; Milenovic, P.; Moortgat, F.; Morovic, S.; Mulders, M.; Neugebauer, H.; Orfanelli, S.; Orsini, L.; Pape, L.; Perez, E.; Peruzzi, M.; Petrilli, A.; Petrucciani, G.; Pfeiffer, A.; Pierini, M.; Racz, A.; Reis, T.; Rolandi, G.; Rovere, M.; Sakulin, H.; Sauvan, J. B.; Schäfer, C.; Schwick, C.; Seidel, M.; Sharma, A.; Silva, P.; Sphicas, P.; Steggemann, J.; Stoye, M.; Takahashi, Y.; Tosi, M.; Treille, D.; Triossi, A.; Tsirou, A.; Veckalns, V.; Veres, G. I.; Verweij, M.; Wardle, N.; Wöhri, H. K.; Zagozdzinska, A.; Zeuner, W. D.; Bertl, W.; Deiters, K.; Erdmann, W.; Horisberger, R.; Ingram, Q.; Kaestli, H. C.; Kotlinski, D.; Langenegger, U.; Rohe, T.; Wiederkehr, S. A.; Bachmair, F.; Bäni, L.; Bianchini, L.; Casal, B.; Dissertori, G.; Dittmar, M.; Donegà, M.; Grab, C.; Heidegger, C.; Hits, D.; Hoss, J.; Kasieczka, G.; Lustermann, W.; Mangano, B.; Marionneau, M.; Martinez Ruiz del Arbol, P.; Masciovecchio, M.; Meinhard, M. T.; Meister, D.; Micheli, F.; Musella, P.; Nessi-Tedaldi, F.; Pandolfi, F.; Pata, J.; Pauss, F.; Perrin, G.; Perrozzi, L.; Quittnat, M.; Rossini, M.; Schönenberger, M.; Starodumov, A.; Tavolaro, V. R.; Theofilatos, K.; Wallny, R.; Aarrestad, T. K.; Amsler, C.; Caminada, L.; Canelli, M. F.; De Cosa, A.; Donato, S.; Galloni, C.; Hinzmann, A.; Hreus, T.; Kilminster, B.; Ngadiuba, J.; Pinna, D.; Rauco, G.; Robmann, P.; Salerno, D.; Seitz, C.; Yang, Y.; Zucchetta, A.; Candelise, V.; Doan, T. H.; Jain, Sh.; Khurana, R.; Konyushikhin, M.; Kuo, C. M.; Lin, W.; Pozdnyakov, A.; Yu, S. S.; Kumar, Arun; Chang, P.; Chang, Y. H.; Chao, Y.; Chen, K. F.; Chen, P. H.; Fiori, F.; Hou, W.-S.; Hsiung, Y.; Liu, Y. F.; Lu, R.-S.; Miñano Moya, M.; Paganis, E.; Psallidas, A.; Tsai, J. f.; Asavapibhop, B.; Singh, G.; Srimanobhas, N.; Suwonjandee, N.; Adiguzel, A.; Bakirci, M. N.; Boran, F.; Cerci, S.; Damarseckin, S.; Demiroglu, Z. S.; Dozen, C.; Dumanoglu, I.; Girgis, S.; Gokbulut, G.; Guler, Y.; Hos, I.; Kangal, E. E.; Kara, O.; Kayis Topaksu, A.; Kiminsu, U.; Oglakci, M.; Onengut, G.; Ozdemir, K.; Tali, B.; Turkcapar, S.; Zorbakir, I. S.; Zorbilmez, C.; Bilin, B.; Bilmis, S.; Isildak, B.; Karapinar, G.; Yalvac, M.; Zeyrek, M.; Gülmez, E.; Kaya, M.; Kaya, O.; Yetkin, E. A.; Yetkin, T.; Cakir, A.; Cankocak, K.; Sen, S.; Grynyov, B.; Levchuk, L.; Sorokin, P.; Aggleton, R.; Ball, F.; Beck, L.; Brooke, J. J.; Burns, D.; Clement, E.; Cussans, D.; Flacher, H.; Goldstein, J.; Grimes, M.; Heath, G. P.; Heath, H. F.; Jacob, J.; Kreczko, L.; Lucas, C.; Newbold, D. M.; Paramesvaran, S.; Poll, A.; Sakuma, T.; Seif El Nasr-storey, S.; Smith, D.; Smith, V. J.; Bell, K. W.; Belyaev, A.; Brew, C.; Brown, R. M.; Calligaris, L.; Cieri, D.; Cockerill, D. J. A.; Coughlan, J. A.; Harder, K.; Harper, S.; Olaiya, E.; Petyt, D.; Shepherd-Themistocleous, C. H.; Thea, A.; Tomalin, I. R.; Williams, T.; Baber, M.; Bainbridge, R.; Buchmuller, O.; Bundock, A.; Casasso, S.; Citron, M.; Colling, D.; Corpe, L.; Dauncey, P.; Davies, G.; De Wit, A.; Della Negra, M.; Di Maria, R.; Dunne, P.; Elwood, A.; Futyan, D.; Haddad, Y.; Hall, G.; Iles, G.; James, T.; Lane, R.; Laner, C.; Lyons, L.; Magnan, A.-M.; Malik, S.; Mastrolorenzo, L.; Nash, J.; Nikitenko, A.; Pela, J.; Penning, B.; Pesaresi, M.; Raymond, D. M.; Richards, A.; Rose, A.; Scott, E.; Seez, C.; Summers, S.; Tapper, A.; Uchida, K.; Vazquez Acosta, M.; Virdee, T.; Wright, J.; Zenz, S. C.; Cole, J. E.; Hobson, P. R.; Khan, A.; Kyberd, P.; Reid, I. D.; Symonds, P.; Teodorescu, L.; Turner, M.; Borzou, A.; Call, K.; Dittmann, J.; Hatakeyama, K.; Liu, H.; Pastika, N.; Bartek, R.; Dominguez, A.; Buccilli, A.; Cooper, S. I.; Henderson, C.; Rumerio, P.; West, C.; Arcaro, D.; Avetisyan, A.; Bose, T.; Gastler, D.; Rankin, D.; Richardson, C.; Rohlf, J.; Sulak, L.; Zou, D.; Benelli, G.; Cutts, D.; Garabedian, A.; Hakala, J.; Heintz, U.; Hogan, J. M.; Jesus, O.; Kwok, K. H. M.; Laird, E.; Landsberg, G.; Mao, Z.; Narain, M.; Piperov, S.; Sagir, S.; Spencer, E.; Syarif, R.; Breedon, R.; Burns, D.; Calderon De La Barca Sanchez, M.; Chauhan, S.; Chertok, M.; Conway, J.; Conway, R.; Cox, P. T.; Erbacher, R.; Flores, C.; Funk, G.; Gardner, M.; Ko, W.; Lander, R.; Mclean, C.; Mulhearn, M.; Pellett, D.; Pilot, J.; Shalhout, S.; Shi, M.; Smith, J.; Squires, M.; Stolp, D.; Tos, K.; Tripathi, M.; Bachtis, M.; Bravo, C.; Cousins, R.; Dasgupta, A.; Florent, A.; Hauser, J.; Ignatenko, M.; Mccoll, N.; Saltzberg, D.; Schnaible, C.; Valuev, V.; Weber, M.; Bouvier, E.; Burt, K.; Clare, R.; Ellison, J.; Gary, J. W.; Ghiasi Shirazi, S. M. A.; Hanson, G.; Heilman, J.; Jandir, P.; Kennedy, E.; Lacroix, F.; Long, O. R.; Olmedo Negrete, M.; Paneva, M. I.; Shrinivas, A.; Si, W.; Wei, H.; Wimpenny, S.; Yates, B. R.; Branson, J. G.; Cerati, G. B.; Cittolin, S.; Derdzinski, M.; Gerosa, R.; Holzner, A.; Klein, D.; Krutelyov, V.; Letts, J.; Macneill, I.; Olivito, D.; Padhi, S.; Pieri, M.; Sani, M.; Sharma, V.; Simon, S.; Tadel, M.; Vartak, A.; Wasserbaech, S.; Welke, C.; Wood, J.; Würthwein, F.; Yagil, A.; Zevi Della Porta, G.; Amin, N.; Bhandari, R.; Bradmiller-Feld, J.; Campagnari, C.; Dishaw, A.; Dutta, V.; Franco Sevilla, M.; George, C.; Golf, F.; Gouskos, L.; Gran, J.; Heller, R.; Incandela, J.; Mullin, S. D.; Ovcharova, A.; Qu, H.; Richman, J.; Stuart, D.; Suarez, I.; Yoo, J.; Anderson, D.; Bendavid, J.; Bornheim, A.; Bunn, J.; Duarte, J.; Lawhorn, J. M.; Mott, A.; Newman, H. B.; Pena, C.; Spiropulu, M.; Vlimant, J. R.; Xie, S.; Zhu, R. Y.; Andrews, M. B.; Ferguson, T.; Paulini, M.; Russ, J.; Sun, M.; Vogel, H.; Vorobiev, I.; Weinberg, M.; Cumalat, J. P.; Ford, W. T.; Jensen, F.; Johnson, A.; Krohn, M.; Leontsinis, S.; Mulholland, T.; Stenson, K.; Wagner, S. R.; Alexander, J.; Chaves, J.; Chu, J.; Dittmer, S.; Mcdermott, K.; Mirman, N.; Patterson, J. R.; Rinkevicius, A.; Ryd, A.; Skinnari, L.; Soffi, L.; Tan, S. M.; Tao, Z.; Thom, J.; Tucker, J.; Wittich, P.; Zientek, M.; Winn, D.; Abdullin, S.; Albrow, M.; Apollinari, G.; Apresyan, A.; Banerjee, S.; Bauerdick, L. A. T.; Beretvas, A.; Berryhill, J.; Bhat, P. C.; Bolla, G.; Burkett, K.; Butler, J. N.; Cheung, H. W. K.; Chlebana, F.; Cihangir, S.; Cremonesi, M.; Elvira, V. D.; Fisk, I.; Freeman, J.; Gottschalk, E.; Gray, L.; Green, D.; Grünendahl, S.; Gutsche, O.; Hare, D.; Harris, R. M.; Hasegawa, S.; Hirschauer, J.; Hu, Z.; Jayatilaka, B.; Jindariani, S.; Johnson, M.; Joshi, U.; Klima, B.; Kreis, B.; Lammel, S.; Linacre, J.; Lincoln, D.; Lipton, R.; Liu, M.; Liu, T.; Lopes De Sá, R.; Lykken, J.; Maeshima, K.; Magini, N.; Marraffino, J. M.; Maruyama, S.; Mason, D.; McBride, P.; Merkel, P.; Mrenna, S.; Nahn, S.; O'Dell, V.; Pedro, K.; Prokofyev, O.; Rakness, G.; Ristori, L.; Sexton-Kennedy, E.; Soha, A.; Spalding, W. J.; Spiegel, L.; Stoynev, S.; Strait, J.; Strobbe, N.; Taylor, L.; Tkaczyk, S.; Tran, N. V.; Uplegger, L.; Vaandering, E. W.; Vernieri, C.; Verzocchi, M.; Vidal, R.; Wang, M.; Weber, H. A.; Whitbeck, A.; Wu, Y.; Acosta, D.; Avery, P.; Bortignon, P.; Bourilkov, D.; Brinkerhoff, A.; Carnes, A.; Carver, M.; Curry, D.; Das, S.; Field, R. D.; Furic, I. K.; Konigsberg, J.; Korytov, A.; Low, J. F.; Ma, P.; Matchev, K.; Mei, H.; Mitselmakher, G.; Rank, D.; Shchutska, L.; Sperka, D.; Thomas, L.; Wang, J.; Wang, S.; Yelton, J.; Linn, S.; Markowitz, P.; Martinez, G.; Rodriguez, J. L.; Ackert, A.; Adams, T.; Askew, A.; Bein, S.; Hagopian, S.; Hagopian, V.; Johnson, K. F.; Kolberg, T.; Perry, T.; Prosper, H.; Santra, A.; Yohay, R.; Baarmand, M. M.; Bhopatkar, V.; Colafranceschi, S.; Hohlmann, M.; Noonan, D.; Roy, T.; Yumiceva, F.; Adams, M. R.; Apanasevich, L.; Berry, D.; Betts, R. R.; Cavanaugh, R.; Chen, X.; Evdokimov, O.; Gerber, C. E.; Hangal, D. A.; Hofman, D. J.; Jung, K.; Kamin, J.; Sandoval Gonzalez, I. D.; Trauger, H.; Varelas, N.; Wang, H.; Wu, Z.; Zhang, J.; Bilki, B.; Clarida, W.; Dilsiz, K.; Durgut, S.; Gandrajula, R. P.; Haytmyradov, M.; Khristenko, V.; Merlo, J.-P.; Mermerkaya, H.; Mestvirishvili, A.; Moeller, A.; Nachtman, J.; Ogul, H.; Onel, Y.; Ozok, F.; Penzo, A.; Snyder, C.; Tiras, E.; Wetzel, J.; Yi, K.; Blumenfeld, B.; Cocoros, A.; Eminizer, N.; Fehling, D.; Feng, L.; Gritsan, A. V.; Maksimovic, P.; Roskes, J.; Sarica, U.; Swartz, M.; Xiao, M.; You, C.; Al-bataineh, A.; Baringer, P.; Bean, A.; Boren, S.; Bowen, J.; Castle, J.; Forthomme, L.; Khalil, S.; Kropivnitskaya, A.; Majumder, D.; Mcbrayer, W.; Murray, M.; Sanders, S.; Stringer, R.; Tapia Takaki, J. D.; Wang, Q.; Ivanov, A.; Kaadze, K.; Maravin, Y.; Mohammadi, A.; Saini, L. K.; Skhirtladze, N.; Toda, S.; Rebassoo, F.; Wright, D.; Anelli, C.; Baden, A.; Baron, O.; Belloni, A.; Calvert, B.; Eno, S. C.; Ferraioli, C.; Gomez, J. A.; Hadley, N. J.; Jabeen, S.; Jeng, G. Y.; Kellogg, R. G.; Kunkle, J.; Mignerey, A. C.; Ricci-Tam, F.; Shin, Y. H.; Skuja, A.; Tonjes, M. B.; Tonwar, S. C.; Abercrombie, D.; Allen, B.; Apyan, A.; Azzolini, V.; Barbieri, R.; Baty, A.; Bi, R.; Bierwagen, K.; Brandt, S.; Busza, W.; Cali, I. A.; D'Alfonso, M.; Demiragli, Z.; Gomez Ceballos, G.; Goncharov, M.; Hsu, D.; Iiyama, Y.; Innocenti, G. M.; Klute, M.; Kovalskyi, D.; Krajczar, K.; Lai, Y. S.; Lee, Y.-J.; Levin, A.; Luckey, P. D.; Maier, B.; Marini, A. C.; Mcginn, C.; Mironov, C.; Narayanan, S.; Niu, X.; Paus, C.; Roland, C.; Roland, G.; Salfeld-Nebgen, J.; Stephans, G. S. F.; Tatar, K.; Velicanu, D.; Wang, J.; Wang, T. W.; Wyslouch, B.; Benvenuti, A. C.; Chatterjee, R. M.; Evans, A.; Hansen, P.; Kalafut, S.; Kao, S. C.; Kubota, Y.; Lesko, Z.; Mans, J.; Nourbakhsh, S.; Ruckstuhl, N.; Rusack, R.; Tambe, N.; Turkewitz, J.; Acosta, J. G.; Oliveros, S.; Avdeeva, E.; Bloom, K.; Claes, D. R.; Fangmeier, C.; Gonzalez Suarez, R.; Kamalieddin, R.; Kravchenko, I.; Malta Rodrigues, A.; Monroy, J.; Siado, J. E.; Snow, G. R.; Stieger, B.; Alyari, M.; Dolen, J.; Godshalk, A.; Harrington, C.; Iashvili, I.; Kaisen, J.; Nguyen, D.; Parker, A.; Rappoccio, S.; Roozbahani, B.; Alverson, G.; Barberis, E.; Hortiangtham, A.; Massironi, A.; Morse, D. M.; Nash, D.; Orimoto, T.; Teixeira De Lima, R.; Trocino, D.; Wang, R.-J.; Wood, D.; Bhattacharya, S.; Charaf, O.; Hahn, K. A.; Mucia, N.; Odell, N.; Pollack, B.; Schmitt, M. H.; Sung, K.; Trovato, M.; Velasco, M.; Dev, N.; Hildreth, M.; Hurtado Anampa, K.; Jessop, C.; Karmgard, D. J.; Kellams, N.; Lannon, K.; Marinelli, N.; Meng, F.; Mueller, C.; Musienko, Y.; Planer, M.; Reinsvold, A.; Ruchti, R.; Rupprecht, N.; Smith, G.; Taroni, S.; Wayne, M.; Wolf, M.; Woodard, A.; Alimena, J.; Antonelli, L.; Bylsma, B.; Durkin, L. S.; Flowers, S.; Francis, B.; Hart, A.; Hill, C.; Ji, W.; Liu, B.; Luo, W.; Puigh, D.; Winer, B. L.; Wulsin, H. W.; Cooperstein, S.; Driga, O.; Elmer, P.; Hardenbrook, J.; Hebda, P.; Lange, D.; Luo, J.; Marlow, D.; Medvedeva, T.; Mei, K.; Ojalvo, I.; Olsen, J.; Palmer, C.; Piroué, P.; Stickland, D.; Svyatkovskiy, A.; Tully, C.; Malik, S.; Barker, A.; Barnes, V. E.; Folgueras, S.; Gutay, L.; Jha, M. K.; Jones, M.; Jung, A. W.; Khatiwada, A.; Miller, D. H.; Neumeister, N.; Schulte, J. F.; Shi, X.; Sun, J.; Wang, F.; Xie, W.; Parashar, N.; Stupak, J.; Adair, A.; Akgun, B.; Chen, Z.; Ecklund, K. M.; Geurts, F. J. M.; Guilbaud, M.; Li, W.; Michlin, B.; Northup, M.; Padley, B. P.; Roberts, J.; Rorie, J.; Tu, Z.; Zabel, J.; Betchart, B.; Bodek, A.; de Barbaro, P.; Demina, R.; Duh, Y. t.; Ferbel, T.; Galanti, M.; Garcia-Bellido, A.; Han, J.; Hindrichs, O.; Khukhunaishvili, A.; Lo, K. H.; Tan, P.; Verzetti, M.; Agapitos, A.; Chou, J. P.; Gershtein, Y.; Gómez Espinosa, T. A.; Halkiadakis, E.; Heindl, M.; Hughes, E.; Kaplan, S.; Kunnawalkam Elayavalli, R.; Kyriacou, S.; Lath, A.; Montalvo, R.; Nash, K.; Osherson, M.; Saka, H.; Salur, S.; Schnetzer, S.; Sheffield, D.; Somalwar, S.; Stone, R.; Thomas, S.; Thomassen, P.; Walker, M.; Delannoy, A. G.; Foerster, M.; Heideman, J.; Riley, G.; Rose, K.; Spanier, S.; Thapa, K.; Bouhali, O.; Celik, A.; Dalchenko, M.; De Mattia, M.; Delgado, A.; Dildick, S.; Eusebi, R.; Gilmore, J.; Huang, T.; Juska, E.; Kamon, T.; Mueller, R.; Pakhotin, Y.; Patel, R.; Perloff, A.; Perniè, L.; Rathjens, D.; Safonov, A.; Tatarinov, A.; Ulmer, K. A.; Akchurin, N.; Damgov, J.; De Guio, F.; Dragoiu, C.; Dudero, P. R.; Faulkner, J.; Gurpinar, E.; Kunori, S.; Lamichhane, K.; Lee, S. W.; Libeiro, T.; Peltola, T.; Undleeb, S.; Volobouev, I.; Wang, Z.; Greene, S.; Gurrola, A.; Janjam, R.; Johns, W.; Maguire, C.; Melo, A.; Ni, H.; Sheldon, P.; Tuo, S.; Velkovska, J.; Xu, Q.; Arenton, M. W.; Barria, P.; Cox, B.; Hirosky, R.; Ledovskoy, A.; Li, H.; Neu, C.; Sinthuprasith, T.; Sun, X.; Wang, Y.; Wolfe, E.; Xia, F.; Clarke, C.; Harr, R.; Karchin, P. E.; Sturdy, J.; Zaleski, S.; Belknap, D. A.; Buchanan, J.; Caillol, C.; Dasu, S.; Dodd, L.; Duric, S.; Gomber, B.; Grothe, M.; Herndon, M.; Hervé, A.; Hussain, U.; Klabbers, P.; Lanaro, A.; Levine, A.; Long, K.; Loveless, R.; Pierro, G. A.; Polese, G.; Ruggles, T.; Savin, A.; Smith, N.; Smith, W. H.; Taylor, D.; Woods, N.; CMS Collaboration

    2017-08-01

    A measurement of the top quark mass (Mt) in the dileptonic t t ¯ decay channel is performed using data from proton-proton collisions at a center-of-mass energy of 8 TeV. The data was recorded by the CMS experiment at the LHC and corresponds to an integrated luminosity of 19.7 ±0.5 fb-1 . Events are selected with two oppositely charged leptons (ℓ=e , μ ) and two jets identified as originating from b quarks. The analysis is based on three kinematic observables whose distributions are sensitive to the value of Mt. An invariant mass observable, Mb ℓ, and a "stransverse mass" observable, MT 2, are employed in a simultaneous fit to determine the value of Mt and an overall jet energy scale factor (JSF). A complementary approach is used to construct an invariant mass observable, Mb ℓν, that is combined with MT 2 to measure Mt. The shapes of the observables, along with their evolutions in Mt and JSF, are modeled by a nonparametric Gaussian process regression technique. The sensitivity of the observables to the value of Mt is investigated using a Fisher information density method. The top quark mass is measured to be 172.22 ±0.18 (stat ) -0.93+0.89(syst ) GeV .

  7. Continuous cultures of Pseudomonas putida mt-2 overcome catabolic function loss under real case operating conditions.

    PubMed

    Muñoz, Raúl; Hernández, María; Segura, Ana; Gouveia, Joao; Rojas, Antonia; Ramos, Juan Luis; Villaverde, Santiago

    2009-05-01

    The long-term performance and stability of Pseudomonas putida mt-2 cultures, a toluene-sensitive strain harboring the genes responsible for toluene biodegradation in the archetypal plasmid pWW0, was investigated in a chemostat bioreactor functioning under real case operating conditions. The process was operated at a dilution rate of 0.1 h(-1) under toluene loading rates of 259 +/- 23 and 801 +/- 78 g m(-3) h(-1) (inlet toluene concentrations of 3.5 and 10.9 g m(-3), respectively). Despite the deleterious effects of toluene and its degradation intermediates, the phenotype of this sensitive P. putida culture rapidly recovered from a 95% Tol(-) population at day 4 to approx. 100% Tol(+) cells from day 13 onward, sustaining elimination capacities of 232 +/- 10 g m(-3) h(-1) at 3.5 g Tol m(-3) and 377 +/- 13 g m(-3) h(-1) at 10.9 g Tol m(-3), which were comparable to those achieved by highly tolerant strains such as P. putida DOT T1E and P. putida F1 under identical experimental conditions. Only one type of Tol(-) variant, harboring a TOL-like plasmid with a 38.5 kb deletion (containing the upper and meta operons for toluene biodegradation), was identified.

  8. Suicide inactivation of catechol 2,3-dioxygenase from Pseudomonas putida mt-2 by 3-halocatechols

    SciTech Connect

    Bartels, I.; Knackmuss, H.J.; Reineke, W.

    1984-03-01

    The inactivation of catechol 2,3-dioxygenase from Pseudomonas putida mt-2 by 3-chloro- and 3-fluorocatechol and the iron-chelating agent Tiron (catechol-3,5-disulfonate) was studied. Whereas inactivation by Tiron is an oxygen-independent and mostly reversible process, inactivation by the 3-halocatechols was only observed in the presence of oxygen and was largely irreversible. The rate constants for inactivation (K/sub 2/) were 1.62 x 10/sup -3/ sec/sup -1/ for 3-chlorocatechol and 2.38 x 10/sup -3/ sec/sup -1/ for 3-fluorocatechol. The inhibitor constants (K/sub i/) were 23 ..mu..M for 3-chlorocatechol and 17 ..mu..M for 3-fluorocatechol. The kinetic data for 3-fluorocatechol could only be obtained in the presence of 2-mercaptoethanol. Besides inactivated enzyme, some 2-hydroxyhexa-2,4-dienoic acid as the actual suicide product of meta-cleavage. A side product of 3-fluorocatechol cleavage is a yellow compound with the spectral characteristics of a 2-hydroxy-6-oxohexa-2,4-dienoci acid indicating 1,6-cleavage. Rates of inactivation by 3-fluorocatechol were reduced in the presence of superoxide dismutase, catalase, formate, and mannitol, which implies that superoxide anion, hydrogen peroxide, and hydroxyl radical exhibit additional inactivation. 64 references.

  9. Physiological states and energetic adaptation during growth of Pseudomonas putida mt-2 on glucose.

    PubMed

    Latrach Tlemçani, Leith; Corroler, David; Barillier, Daniel; Mosrati, Ridha

    2008-08-01

    Kinetic study of growth of Pseudomonas putida mt-2 was investigated in batch culture under aerobic conditions, on glucose as initial carbon and energy source. Cell growth was continuous and three phases were found regarding accumulation of intermediates: (1) glucose was largely converted to gluconate and 2-ketogluconate, (2) then gluconate was converted to 2-ketogluconate and (3) the latter was consumed after gluconate depletion. Examination of growth kinetics and yields showed that glucose flux was mainly oriented to oxidation reduction in the periplasm and less towards biosynthesis. Values of respiratory quotient and of CO2/biomass and O2/biomass yields were characteristic of each phase. Main enzymatic activities involved in the use of these substrates were always detected meaning that concomitant assimilation is possible. However the levels of these activities varied during growth. Membrane conversions seem to have a significant energetic contribution explaining the higher specific growth rate obtained in glucose phase compared to gluconate and 2-ketogluconate ones. This is also noticeable through the evolution of the yields Y(O2)/X and Y(CO2)/X. Although the three convergent pathways are operational and can be genetically controlled, the progression of the culture in successive phases highlights an overall level of regulation in response to the energetic needs.

  10. Strong WW Interaction at LHC

    SciTech Connect

    Pelaez, Jose R

    1998-12-14

    We present a brief pedagogical introduction to the Effective Electroweak Chiral Lagrangians, which provide a model independent description of the WW interactions in the strong regime. When it is complemented with some unitarization or a dispersive approach, this formalism allows the study of the general strong scenario expected at the LHC, including resonances.

  11. Localization of genes encoding metallothionein-like protein (mt2 and smtb) in the brain of zebrafish.

    PubMed

    Teoh, Seong Lin; Ogawa, Satoshi; Parhar, Ishwar S

    2015-12-01

    Metallothionein (MT) is a small cysteine-rich heavy metal-binding protein involved in metal homeostasis, detoxification and free radical-scavenging. MT is ubiquitously expressed in several tissues, but its role in the central nervous system is not well understood. In this study, we identified two MT homologous genes (mt2 and smtb) in the zebrafish. Digoxigenin-in situ hybridization showed the expression of mt2 and smtb genes in the ventricular layers in the telencephalon, diencephalon, mesencephalon and rhombencephalon, most of which are cell proliferating regions in the brain of zebrafish. Cellular characteristics of MT genes expressing cells were examined by double-labelling with markers for neurons (HuC/D) and astrocytes (glial fibrillary acidic protein, GFAP and S100 protein) and cell proliferation marker (PCNA). mt2 and smtb mRNAs are expressed in neurons and not in astrocytes, and they were co-localized with PCNA. These results suggest that mt2 and smtb may play an important role in neurogenesis and neuroprotection.

  12. Measurement of the top quark mass in the dilepton channel using mT2 at CDF

    NASA Astrophysics Data System (ADS)

    Aaltonen, T.; Adelman, J.; Álvarez González, B.; Amerio, S.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Apollinari, G.; Apresyan, A.; Arisawa, T.; Artikov, A.; Asaadi, J.; Ashmanskas, W.; Attal, A.; Aurisano, A.; Azfar, F.; Badgett, W.; Barbaro-Galtieri, A.; Barnes, V. E.; Barnett, B. A.; Barria, P.; Bartos, P.; Bauer, G.; Beauchemin, P.-H.; Bedeschi, F.; Beecher, D.; Behari, S.; Bellettini, G.; Bellinger, J.; Benjamin, D.; Beretvas, A.; Bhatti, A.; Binkley, M.; Bisello, D.; Bizjak, I.; Blair, R. E.; Blocker, C.; Blumenfeld, B.; Bocci, A.; Bodek, A.; Boisvert, V.; Bortoletto, D.; Boudreau, J.; Boveia, A.; Brau, B.; Bridgeman, A.; Brigliadori, L.; Bromberg, C.; Brubaker, E.; Budagov, J.; Budd, H. S.; Budd, S.; Burkett, K.; Busetto, G.; Bussey, P.; Buzatu, A.; Byrum, K. L.; Cabrera, S.; Calancha, C.; Camarda, S.; Campanelli, M.; Campbell, M.; Canelli, F.; Canepa, A.; Carls, B.; Carlsmith, D.; Carosi, R.; Carrillo, S.; Carron, S.; Casal, B.; Casarsa, M.; Castro, A.; Catastini, P.; Cauz, D.; Cavaliere, V.; Cavalli-Sforza, M.; Cerri, A.; Cerrito, L.; Chang, S. H.; Chen, Y. C.; Chertok, M.; Chiarelli, G.; Chlachidze, G.; Chlebana, F.; Cho, K.; Chokheli, D.; Chou, J. P.; Choudalakis, G.; Chung, K.; Chung, W. H.; Chung, Y. S.; Chwalek, T.; Ciobanu, C. I.; Ciocci, M. A.; Clark, A.; Clark, D.; Compostella, G.; Convery, M. E.; Conway, J.; Corbo, M.; Cordelli, M.; Cox, C. A.; Cox, D. J.; Crescioli, F.; Cuenca Almenar, C.; Cuevas, J.; Culbertson, R.; Cully, J. C.; Dagenhart, D.; Datta, M.; Davies, T.; de Barbaro, P.; de Cecco, S.; Deisher, A.; de Lorenzo, G.; Dell'Orso, M.; Deluca, C.; Demortier, L.; Deng, J.; Deninno, M.; D'Errico, M.; di Canto, A.; di Giovanni, G. P.; di Ruzza, B.; Dittmann, J. R.; D'Onofrio, M.; Donati, S.; Dong, P.; Dorigo, T.; Dube, S.; Ebina, K.; Elagin, A.; Erbacher, R.; Errede, D.; Errede, S.; Ershaidat, N.; Eusebi, R.; Fang, H. C.; Farrington, S.; Fedorko, W. T.; Feild, R. G.; Feindt, M.; Fernandez, J. P.; Ferrazza, C.; Field, R.; Flanagan, G.; Forrest, R.; Frank, M. J.; Franklin, M.; Freeman, J. C.; Furic, I.; Gallinaro, M.; Galyardt, J.; Garberson, F.; Garcia, J. E.; Garfinkel, A. F.; Garosi, P.; Genser, K.; Gerberich, H.; Gerdes, D.; Gessler, A.; Giagu, S.; Giakoumopoulou, V.; Giannetti, P.; Gibson, K.; Gimmell, J. L.; Ginsburg, C. M.; Giokaris, N.; Giordani, M.; Giromini, P.; Giunta, M.; Giurgiu, G.; Glagolev, V.; Glenzinski, D.; Gold, M.; Goldschmidt, N.; Golossanov, A.; Gomez, G.; Gomez-Ceballos, G.; Goncharov, M.; González, O.; Gorelov, I.; Goshaw, A. T.; Goulianos, K.; Gresele, A.; Grinstein, S.; Grosso-Pilcher, C.; Group, R. C.; Grundler, U.; Guimaraes da Costa, J.; Gunay-Unalan, Z.; Haber, C.; Hahn, K.; Hahn, S. R.; Halkiadakis, E.; Han, B.-Y.; Han, J. Y.; Happacher, F.; Hara, K.; Hare, D.; Hare, M.; Harr, R. F.; Hartz, M.; Hatakeyama, K.; Hays, C.; Heck, M.; Heinrich, J.; Henderson, C.; Herndon, M.; Heuser, J.; Hewamanage, S.; Hidas, D.; Hill, C. S.; Hirschbuehl, D.; Hocker, A.; Hou, S.; Houlden, M.; Hsu, S.-C.; Huffman, B. T.; Hughes, R. E.; Hurwitz, M.; Husemann, U.; Hussein, M.; Huston, J.; Incandela, J.; Introzzi, G.; Iori, M.; Ivanov, A.; James, E.; Jang, D.; Jayatilaka, B.; Jeon, E. J.; Jha, M. K.; Jindariani, S.; Johnson, W.; Jones, M.; Joo, K. K.; Jun, S. Y.; Jung, J. E.; Junk, T. R.; Kamon, T.; Kar, D.; Karchin, P. E.; Kato, Y.; Kephart, R.; Ketchum, W.; Keung, J.; Khotilovich, V.; Kilminster, B.; Kim, D. H.; Kim, H. S.; Kim, H. W.; Kim, J. E.; Kim, M. J.; Kim, S. B.; Kim, S. H.; Kim, Y. K.; Kimura, N.; Kirsch, L.; Klimenko, S.; Knuteson, B.; Kondo, K.; Kong, D. J.; Konigsberg, J.; Korytov, A.; Kotwal, A. V.; Kreps, M.; Kroll, J.; Krop, D.; Krumnack, N.; Kruse, M.; Krutelyov, V.; Kuhr, T.; Kulkarni, N. P.; Kurata, M.; Kwang, S.; Laasanen, A. T.; Lami, S.; Lammel, S.; Lancaster, M.; Lander, R. L.; Lannon, K.; Lath, A.; Latino, G.; Lazzizzera, I.; Lecompte, T.; Lee, E.; Lee, H. S.; Lee, J. S.; Lee, S. W.; Leone, S.; Lewis, J. D.; Lin, C.-J.; Linacre, J.; Lindgren, M.; Lipeles, E.; Lister, A.; Litvintsev, D. O.; Liu, C.; Liu, T.; Lockyer, N. S.; Loginov, A.; Lovas, L.; Lucchesi, D.; Lueck, J.; Lujan, P.; Lukens, P.; Lungu, G.; Lys, J.; Lysak, R.; MacQueen, D.; Madrak, R.; Maeshima, K.; Makhoul, K.; Maksimovic, P.; Malde, S.; Malik, S.; Manca, G.; Manousakis-Katsikakis, A.; Margaroli, F.; Marino, C.; Marino, C. P.; Martin, A.; Martin, V.; Martínez, M.; Martínez-Ballarín, R.; Mastrandrea, P.; Mathis, M.; Mattson, M. E.; Mazzanti, P.; McFarland, K. S.; McIntyre, P.; McNulty, R.; Mehta, A.; Mehtala, P.; Menzione, A.; Mesropian, C.; Miao, T.; Mietlicki, D.; Miladinovic, N.; Miller, R.; Mills, C.; Milnik, M.; Mitra, A.; Mitselmakher, G.; Miyake, H.; Moed, S.; Moggi, N.; Mondragon, M. N.; Moon, C. S.; Moore, R.; Morello, M. J.; Morlock, J.; Movilla Fernandez, P.; Mülmenstädt, J.; Mukherjee, A.; Muller, Th.; Murat, P.; Mussini, M.; Nachtman, J.; Nagai, Y.; Naganoma, J.; Nakamura, K.; Nakano, I.; Napier, A.; Nett, J.; Neu, C.; Neubauer, M. S.; Neubauer, S.; Nielsen, J.; Nodulman, L.; Norman, M.; Norniella, O.; Nurse, E.; Oakes, L.; Oh, S. H.; Oh, Y. D.; Oksuzian, I.; Okusawa, T.; Orava, R.; Osterberg, K.; Pagan Griso, S.; Pagliarone, C.; Palencia, E.; Papadimitriou, V.; Papaikonomou, A.; Paramanov, A. A.; Parks, B.; Pashapour, S.; Patrick, J.; Pauletta, G.; Paulini, M.; Paus, C.; Peiffer, T.; Pellett, D. E.; Penzo, A.; Phillips, T. J.; Piacentino, G.; Pianori, E.; Pinera, L.; Pitts, K.; Plager, C.; Pondrom, L.; Potamianos, K.; Poukhov, O.; Prokoshin, F.; Pronko, A.; Ptohos, F.; Pueschel, E.; Punzi, G.; Pursley, J.; Rademacker, J.; Rahaman, A.; Ramakrishnan, V.; Ranjan, N.; Redondo, I.; Renton, P.; Renz, M.; Rescigno, M.; Richter, S.; Rimondi, F.; Ristori, L.; Robson, A.; Rodrigo, T.; Rodriguez, T.; Rogers, E.; Rolli, S.; Roser, R.; Rossi, M.; Rossin, R.; Roy, P.; Ruiz, A.; Russ, J.; Rusu, V.; Rutherford, B.; Saarikko, H.; Safonov, A.; Sakumoto, W. K.; Santi, L.; Sartori, L.; Sato, K.; Savoy-Navarro, A.; Schlabach, P.; Schmidt, A.; Schmidt, E. E.; Schmidt, M. A.; Schmidt, M. P.; Schmitt, M.; Schwarz, T.; Scodellaro, L.; Scribano, A.; Scuri, F.; Sedov, A.; Seidel, S.; Seiya, Y.; Semenov, A.; Sexton-Kennedy, L.; Sforza, F.; Sfyrla, A.; Shalhout, S. Z.; Shears, T.; Shepard, P. F.; Shimojima, M.; Shiraishi, S.; Shochet, M.; Shon, Y.; Shreyber, I.; Simonenko, A.; Sinervo, P.; Sisakyan, A.; Slaughter, A. J.; Slaunwhite, J.; Sliwa, K.; Smith, J. R.; Snider, F. D.; Snihur, R.; Soha, A.; Somalwar, S.; Sorin, V.; Spreitzer, T.; Squillacioti, P.; Stanitzki, M.; St. Denis, R.; Stelzer, B.; Stelzer-Chilton, O.; Stentz, D.; Strologas, J.; Strycker, G. L.; Suh, J. S.; Sukhanov, A.; Suslov, I.; Taffard, A.; Takashima, R.; Takeuchi, Y.; Tanaka, R.; Tang, J.; Tecchio, M.; Teng, P. K.; Thom, J.; Thome, J.; Thompson, G. A.; Thomson, E.; Tipton, P.; Ttito-Guzmán, P.; Tkaczyk, S.; Toback, D.; Tokar, S.; Tollefson, K.; Tomura, T.; Tonelli, D.; Torre, S.; Torretta, D.; Totaro, P.; Tourneur, S.; Trovato, M.; Tsai, S.-Y.; Tu, Y.; Turini, N.; Ukegawa, F.; Uozumi, S.; van Remortel, N.; Varganov, A.; Vataga, E.; Vázquez, F.; Velev, G.; Vellidis, C.; Vidal, M.; Vila, I.; Vilar, R.; Vogel, M.; Volobouev, I.; Volpi, G.; Wagner, P.; Wagner, R. G.; Wagner, R. L.; Wagner, W.; Wagner-Kuhr, J.; Wakisaka, T.; Wallny, R.; Wang, S. M.; Warburton, A.; Waters, D.; Weinberger, M.; Weinelt, J.; Wester, W. C., III; Whitehouse, B.; Whiteson, D.; Wicklund, A. B.; Wicklund, E.; Wilbur, S.; Williams, G.; Williams, H. H.; Wilson, P.; Winer, B. L.; Wittich, P.; Wolbers, S.; Wolfe, C.; Wolfe, H.; Wright, T.; Wu, X.; Würthwein, F.; Xie, S.; Yagil, A.; Yamamoto, K.; Yamaoka, J.; Yang, U. K.; Yang, Y. C.; Yao, W. M.; Yeh, G. P.; Yi, K.; Yoh, J.; Yorita, K.; Yoshida, T.; Yu, G. B.; Yu, I.; Yu, S. S.; Yun, J. C.; Zanetti, A.; Zeng, Y.; Zhang, X.; Zheng, Y.; Zucchelli, S.; CDF Collaboration

    2010-02-01

    We present measurements of the top quark mass using mT2, a variable related to the transverse mass in events with two missing particles. We use the template method applied to tt¯ dilepton events produced in pp¯ collisions at Fermilab's Tevatron Collider and collected by the CDF detector. From a data sample corresponding to an integrated luminosity of 3.4fb-1, we select 236 tt¯ candidate events. Using the mT2 distribution, we measure the top quark mass to be Mtop=168.0-4.0+4.8(stat)±2.9(syst)GeV/c2. By combining mT2 with the reconstructed top quark mass distributions based on a neutrino weighting method, we measure Mtop=169.3±2.7(stat)±3.2(syst)GeV/c2. This is the first application of the mT2 variable in a mass measurement at a hadron collider.

  13. The SbMT-2 Gene from a Halophyte Confers Abiotic Stress Tolerance and Modulates ROS Scavenging in Transgenic Tobacco

    PubMed Central

    Chaturvedi, Amit Kumar; Patel, Manish Kumar; Mishra, Avinash; Tiwari, Vivekanand; Jha, Bhavanath

    2014-01-01

    Heavy metals are common pollutants of the coastal saline area and Salicornia brachiata an extreme halophyte is frequently exposed to various abiotic stresses including heavy metals. The SbMT-2 gene was cloned and transformed to tobacco for the functional validation. Transgenic tobacco lines (L2, L4, L6 and L13) showed significantly enhanced salt (NaCl), osmotic (PEG) and metals (Zn++, Cu++ and Cd++) tolerance compared to WT plants. Transgenic lines did not show any morphological variation and had enhanced growth parameters viz. shoot length, root length, fresh weight and dry weight. High seed germination percentage, chlorophyll content, relative water content, electrolytic leakage and membrane stability index confirmed that transgenic lines performed better under salt (NaCl), osmotic (PEG) and metals (Zn++, Cu++ and Cd++) stress conditions compared to WT plants. Proline, H2O2 and lipid peroxidation (MDA) analyses suggested the role of SbMT-2 in cellular homeostasis and H2O2 detoxification. Furthermore in vivo localization of H2O2 and O2−; and elevated expression of key antioxidant enzyme encoding genes, SOD, POD and APX evident the possible role of SbMT-2 in ROS scavenging/detoxification mechanism. Transgenic lines showed accumulation of Cu++ and Cd++ in root while Zn++ in stem under stress condition. Under control (unstressed) condition, Zn++ was accumulated more in root but accumulation of Zn++ in stem under stress condition suggested that SbMT-2 may involve in the selective translocation of Zn++ from root to stem. This observation was further supported by the up-regulation of zinc transporter encoding genes NtZIP1 and NtHMA-A under metal ion stress condition. The study suggested that SbMT-2 modulates ROS scavenging and is a potential candidate to be used for phytoremediation and imparting stress tolerance. PMID:25340650

  14. Sleep-promoting action of IIK7, a selective MT2 melatonin receptor agonist in the rat

    PubMed Central

    Fisher, Simon P.; Sugden, David

    2009-01-01

    Several novel melatonin receptor agonists, in addition to various formulations of melatonin itself, are either available or in development for the treatment of insomnia. Melatonin is thought to exert its effects principally through two high affinity, G-protein coupled receptors, MT1 and MT2, though it is not known which subtype is responsible for the sleep-promoting action. The present study used radiotelemetry to record EEG and EMG in un-restrained freely moving rats to monitor the sleep-wake behaviour and examined the acute sleep-promoting activity of an MT2 receptor subtype selective melatonin analog, IIK7. IIK7 is a full agonist at the MT2 receptor subtype but a partial agonist at the MT1 receptor and has ∼90-fold higher affinity for MT2 than MT1. Like melatonin, IIK7 (10 mg/kg i.p.) significantly reduced NREM sleep onset latency and transiently increased the time spent in NREM sleep, but did not alter REM sleep latency or the amount of REM sleep. An analysis of the EEG power spectrum showed no change in delta (1–4 Hz) or theta activity (5–8 Hz) following IIK7 administration. Core body temperature was slightly decreased (∼0.3 °C) by IIK7 compared to vehicle-treated rats. The acute and transient changes in the sleep-wake cycle mimic the changes seen with melatonin and suggest that its sleep-promoting activity is mediated by activation of the MT2 receptor subtype. PMID:19429170

  15. Melatonin, selective and non-selective MT1/MT2 receptors agonists: differential effects on the 24-h vigilance states.

    PubMed

    Ochoa-Sanchez, Rafael; Comai, Stefano; Spadoni, Gilberto; Bedini, Annalida; Tarzia, Giorgio; Gobbi, Gabriella

    2014-02-21

    Melatonin (MLT) is a neurohormone implicated in several physiological processes such as sleep. Contrasting results have been produced on whether or not it may act as a hypnotic agent, and the neurobiological mechanism through which it controls the vigilance states has not yet been elucidated. In this study we investigated the effect of MLT (40 mg/kg), a non-selective MT1/MT2 receptor agonist (UCM793, 40 mg/kg), and a selective MT2 partial agonist (UCM924, 40 mg/kg) on the 24-h vigilance states. EEG and EMG sleep-wake patterns were registered across the 24-h light-dark cycle in adult Sprague-Dawley male rats. MLT decreased (-37%) the latency to the first episode of non rapid eye movement sleep (NREMS), enhanced the power of NREMS delta band (+33%), but did not alter the duration of any of the three vigilance states. Differently, UCM793 increased the number of episodes (+52%) and decreased the length of the episodes (-38%) of wakefulness but did not alter the 24-h duration of wakefulness, NREMS and REMS. UCM924 instead reduced the latency (-56%) and increased (+31%) the duration of NREMS. Moreover, it raised the number of REMS episodes (+57%) but did not affect REMS duration. Taken together, these findings show that MLT and non-selective MT1/MT2 receptor agonists do not increase the quantity of sleep but differently influence the three vigilance states. In addition, they support the evidence that selective MT2 receptor agonists increase NREMS duration compared to MLT and non-selective MT1/MT2 agonists.

  16. Sleep-promoting action of IIK7, a selective MT2 melatonin receptor agonist in the rat.

    PubMed

    Fisher, Simon P; Sugden, David

    2009-06-26

    Several novel melatonin receptor agonists, in addition to various formulations of melatonin itself, are either available or in development for the treatment of insomnia. Melatonin is thought to exert its effects principally through two high affinity, G-protein coupled receptors, MT1 and MT2, though it is not known which subtype is responsible for the sleep-promoting action. The present study used radiotelemetry to record EEG and EMG in un-restrained freely moving rats to monitor the sleep-wake behaviour and examined the acute sleep-promoting activity of an MT2 receptor subtype selective melatonin analog, IIK7. IIK7 is a full agonist at the MT2 receptor subtype but a partial agonist at the MT1 receptor and has approximately 90-fold higher affinity for MT2 than MT1. Like melatonin, IIK7 (10mg/kg i.p.) significantly reduced NREM sleep onset latency and transiently increased the time spent in NREM sleep, but did not alter REM sleep latency or the amount of REM sleep. An analysis of the EEG power spectrum showed no change in delta (1-4 Hz) or theta activity (5-8 Hz) following IIK7 administration. Core body temperature was slightly decreased ( approximately 0.3 degrees C) by IIK7 compared to vehicle-treated rats. The acute and transient changes in the sleep-wake cycle mimic the changes seen with melatonin and suggest that its sleep-promoting activity is mediated by activation of the MT2 receptor subtype.

  17. Phenotypic and biochemical alterations in relation to MT2 gene expression in Plantago ovata Forsk under zinc stress.

    PubMed

    Pramanick, Paulami; Chakraborty, Anindita; Raychaudhuri, Sarmistha Sen

    2017-04-01

    Plantago ovata Forsk is an annual herb with immense medicinal importance, the seed and husk of which is used in the treatment of chronic constipation, irritable bowel syndrome, diarrhea since ancient times. Zinc, an essential metal, is required by plants as they form important components of zinc finger proteins and also aid in synthesis of photosynthetic pigments such as chlorophyll. However, in excess amount Zn causes chlorosis of leaf and shoot tissues and generate reactive oxygen species. The present study is aimed at investigating the changes in expression levels of MT2 gene in Plantago ovata under zinc stress. Data show up to 1.66 fold increase in expression of PoMT2 in 1000 µM ZnSO4·7H2O treated sample. Our study also describes alteration of MT2 gene expressions in Plantago ovata as observed through Real time PCR (qPCR) done by [Formula: see text] method. In this study we have observed an upregulation (or induction) in the PoMT2 gene expression level in 500 and 800 µM ZnSO4·7H2O treated samples but found saturation on further increasing the dose to 1000 µM of ZnSO4·7H2O. Determination of the phenotypic and biochemical changes in Plantago ovata due to exposure to zinc stress of concentrations 500, 800 and 1000 µM revealed oxidative stress. The enhanced expression of MT2 gene in Plantago ovata has a correlation with the increased total antioxidant activity and increased DPPH radical scavenging activity.

  18. Melatonin modulates the functions of porcine granulosa cells via its membrane receptor MT2 in vitro.

    PubMed

    He, Ya-Mei; Deng, Hong-Hui; Shi, Mei-Hong; Bodinga, Bello Musa; Chen, Hua-Li; Han, Zeng-Sheng; Jiang, Zhong-Liang; Li, Qing-Wang

    2016-09-01

    Melatonin (N-acetyl-5-methoxytryptamine) is documented as a hormone involved in the circadian regulation of physiological and neuroendocrine function in mammals. Herein, the effects of melatonin on the functions of porcine granulosa cells in vitro were investigated. Porcine granulosa cells were cultivated with variable concentrations of melatonin (0, 0.001, 0.01, 0.1, 1.0, and 10ng/mL) for 48h. Melatonin receptor agonist (IIK7) and antagonist (Luzindole, 4P-PDOT) were used to further examine the action of melatonin. The results showed optimum cell viability and colony-forming efficiency of porcine granulosa cells at 0.01ng/mL melatonin for 48-h incubation period. The percentage of apoptotic granulosa cells was significantly reduced by 0.01 and 0.1ng/mL melatonin within the 48-h incubation period as compared with the rest of the treatments. Estradiol biosynthesis was significantly stimulated by melatonin supplementation and suppressed for the progesterone secretion; the minimum ratio of progesterone to estradiol was 1.82 in 0.01ng/mL melatonin treatment after 48h of cultivation. Moreover, the expression of BCL-2, CYP17A1, CYP19A1, SOD1, and GPX4 were up-regulated by 0.01ng/mL melatonin or combined with IIK7, but decreased for the mRNA levels of BAX, P53, and CASPASE-3, as compared with control or groups treated with Luzindole or 4P-PDOT in the presence of melatonin. In conclusion, the study demonstrated that melatonin mediated proliferation, apoptosis, and steroidogenesis in porcine granulosa cells predominantly through the activation of melatonin receptor MT2 in vitro, which provided evidence of the beneficial role of melatonin as well as its functional mechanism in porcine granulosa cells in vitro. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Effects of the melatonin MT-1/MT-2 agonist ramelteon on daytime body temperature and sleep.

    PubMed

    Markwald, Rachel R; Lee-Chiong, Teofilo L; Burke, Tina M; Snider, Jesse A; Wright, Kenneth P

    2010-06-01

    A reduction in core temperature and an increase in the distal-proximal skin gradient (DPG) are reported to be associated with shorter sleep onset latencies (SOL) and better sleep quality. Ramelteon is a melatonin MT-1/MT-2 agonist approved for the treatment of insomnia. At night, ramelteon has been reported to shorten SOL. In the present study we tested the hypothesis that ramelteon would reduce core temperature, increase the DPG, as well as shorten SOL, reduce wakefulness after sleep onset (WASO), and increase total sleep time (TST) during a daytime sleep opportunity. Randomized, double-blind, placebo-controlled, cross-over design. Eight mg ramelteon or placebo was administered 2 h prior to a 4-h daytime sleep opportunity. Sleep and chronobiology laboratory. Fourteen healthy adults (5 females), aged (23.2 +/- 4.2 y). Primary outcome measures included core body temperature, the DPG and sleep physiology (minutes of total sleep time [TST], wake after sleep onset [WASO], and SOL). We also assessed as secondary outcomes, proximal and distal skin temperatures, sleep staging and subjective TST. Repeated measures ANOVA revealed ramelteon significantly reduced core temperature and increased the DPG (both P < 0.05). Furthermore, ramelteon reduced WASO and increased TST, and stages 1 and 2 sleep (all P < 0.05). The change in the DPG was negatively correlated with SOL in the ramelteon condition. Ramelteon improved daytime sleep, perhaps mechanistically in part by reducing core temperature and modulating skin temperature. These findings suggest that ramelteon may have promise for the treatment of insomnia associated with circadian misalignment due to circadian sleep disorders.

  20. Cloning and characterization of HbMT2a, a metallothionein gene from Hevea brasiliensis Muell. Arg differently responds to abiotic stress and heavy metals

    SciTech Connect

    Li, Yan; Chen, Yue Yi; Yang, Shu Guang; Tian, Wei Min

    2015-05-22

    Metallothioneins (MTs) are of low molecular mass, cysteine-rich proteins. They play an important role in the detoxification of heavy metals and homeostasis of intracellular metal ions, and protecting against intracellular oxidative damages. In this study a full-length cDNA of type 2 plant metallothioneins, HbMT2a, was isolated from 25 mM Polyethyleneglycol (PEG) stressed leaves of Hevea brasiliensis by RACE. The HbMT2a was 372 bp in length and had a 237 bp open reading frame (ORF) encoding for a protein of 78 amino acid residues with molecular mass of 7.772 kDa. The expression of HbMT2a in the detached leaves of rubber tree clone RY7-33-97 was up-regulated by Me-JA, ABA, PEG, H{sub 2}O{sub 2}, Cu{sup 2+} and Zn{sup 2+}, but down-regulated by water. The role of HbMT2a protein in protecting against metal toxicity was demonstrated in vitro. PET-28a-HbMT2-beared Escherichia coli. Differential expression of HbMT2a upon treatment with 10 °C was observed in the detached leaves of rubber tree clone 93-114 which is cold-resistant and Reken501 which is cold-sensitive. The expression patterns of HbMT2a in the two rubber tree clones may be ascribed to a change in the level of endogenous H{sub 2}O{sub 2}. - Highlights: • Cloning an HbMT2a gene from rubber tree. • Analyzing expression patterns of HbMT2a upon abiotic stress and heavy metal stress. • Finding different expression patterns of HbMT2a among two Hevea germplasm. • The expressed protein of HbMT2a enhances copper and zinc tolerance in Escherichia coli.

  1. Altered MT1 and MT2 melatonin receptors expression in the hippocampus of pilocarpine-induced epileptic rats.

    PubMed

    Rocha, Anna Karynna Alves de Alencar; de Lima, Eliangela; Amaral, Fernanda; Peres, Rafael; Cipolla-Neto, José; Amado, Débora

    2017-06-01

    Clinical and experimental findings show that melatonin may be used as an adjuvant to the treatment of epilepsy-related complications by alleviates sleep disturbances, circadian alterations and attenuates seizures alone or in combination with AEDs. In addition, it has been observed that there is a circadian component on seizures, which cause changes in circadian system and in melatonin production. Nevertheless, the dynamic changes of the melatoninergic system, especially with regard to its membrane receptors (MT1 and MT2) in the natural course of TLE remain largely unknown. The aim of this study was to evaluate the 24-hour profile of MT1 and MT2 mRNA and protein expression in the hippocampus of rats submitted to the pilocarpine-induced epilepsy model analyzing the influence of the circadian rhythm in the expression pattern during the acute, silent, and chronic phases. Melatonin receptor MT1 and MT2 mRNA expression levels were increased in the hippocampus of rats few hours after SE, with MT1 returning to normal levels and MT2 reducing during the silent phase. During the chronic phase, mRNA expression levels of both receptors return to levels close to control, however, presenting a different daily profile, showing that there is a circadian change during the chronic phase. Also, during the acute and silent phase it was possible to verify MT1 label only in CA2 hippocampal region with an increased expression only in the dark period of the acute phase. The MT2 receptor was present in all hippocampal regions, however, it was reduced in the acute phase and it was found in astrocytes. In chronic animals, there is a reduction in the presence of both receptors especially in regions where there is a typical damage derived from epilepsy. Therefore, we conclude that SE induced by pilocarpine is able to change melatonin receptor MT1 and MT2 protein and mRNA expression levels in the hippocampus of rats few hours after SE as well as in silent and chronic phases. Copyright © 2017

  2. Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam.

    PubMed

    Ochoa-Sanchez, Rafael; Rainer, Quentin; Comai, Stefano; Spadoni, Gilberto; Bedini, Annalida; Rivara, Silvia; Fraschini, Franco; Mor, Marco; Tarzia, Giorgio; Gobbi, Gabriella

    2012-12-03

    Melatonin (MLT) is a neurohormone known to be involved in the regulation of anxiety. Most of the physiological actions of MLT in the brain are mediated by two high-affinity G-protein-coupled receptors, denoted MT(1) and MT(2). However, the particular role of these receptors in anxiety remains to be defined. Here we used a novel MT(2)-selective partial agonist, UCM765 to evaluate the involvement of MT(2) receptors in anxiety. Adult male rats were acutely injected with UCM765 (5-10-20mg/kg), MLT (20mg/kg) or diazepam (DZ, 1mg/kg). Anxiety-related behaviors were assessed in the elevated plus maze test (EPMT), novelty suppressed feeding test (NSFT) and open field test (OFT). UCM765 at the dose of 10mg/kg showed anxiolytic-like properties by increasing the time spent in the open arm of the EPMT, and by reducing the latency to eat in a novel environment in the NSFT. In the EPMT, animals treated with UCM765 (10mg/kg) or MLT (20mg/kg) spent more time in the open arms compared to vehicle-treated animals, but to a lesser extent compared to DZ (1mg/kg). In the NSFT, all treatments similarly decreased the latency to eat in a novel environment compared to vehicle. UCM765 and MLT did not affect the total time and the number of entries into the central area of the OFT, but unlike DZ, did not impair locomotion. The anxiolytic effects of UCM765 and MLT in the EPMT and the NSFT were blocked using a pre-treatment with the MT(1)/MT(2) antagonist luzindole (10mg/kg) or the MT(2) antagonist 4P-PDOT (10mg/kg). These results demonstrated, for the first time, the anxiolytic properties of UCM765 and suggest that MT(2)-receptors may be considered a novel target for the development of anxiolytic drugs. Copyright © 2012 Elsevier Inc. All rights reserved.

  3. Ligand binding to the human MT2 melatonin receptor: The role of residues in transmembrane domains 3, 6, and 7

    SciTech Connect

    Mazna, Petr; Berka, Karel; Balik, Ales; Svoboda, Petr; Obsilova, Veronika; Obsil, Tomas . E-mail: teisingr@biomed.cas.cz

    2005-07-08

    To better understand the mechanism of interactions between G-protein-coupled melatonin receptors and their ligands, our previously reported homology model of human MT2 receptor with docked 2-iodomelatonin was further refined and used to select residues within TM3, TM6, and TM7 potentially important for receptor-ligand interactions. Selected residues were mutated and radioligand-binding assay was used to test the binding affinities of hMT2 receptors transiently expressed in HEK293 cells. Our data demonstrate that residues N268 and A275 in TM6 as well as residues V291 and L295 in TM7 are essential for 2-iodomelatonin binding to the hMT2 receptor, while TM3 residues M120, G121, V124, and I125 may participate in binding of other receptor agonists and/or antagonists. Presented data also hint at possible specific interaction between the side-chain of Y188 in second extracellular loop and N-acetyl group of 2-iodomelatonin.

  4. CCNP Award Paper: Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology

    PubMed Central

    Comai, Stefano; Gobbi, Gabriella

    2014-01-01

    Background Melatonin (MLT) is a pleiotropic neurohormone controlling many physiological processes and whose dysfunction may contribute to several different diseases, such as neurodegenerative diseases, circadian and mood disorders, insomnia, type 2 diabetes and pain. Melatonin is synthesized by the pineal gland during the night and acts through 2 G-protein coupled receptors (GPCRs), MT1 (MEL1a) and MT2 (MEL1b). Although a bulk of research has examined the physiopathological effects of MLT, few studies have investigated the selective role played by MT1 and MT2 receptors. Here we have reviewed current knowledge about the implications of MT2 receptors in brain functions. Methods We searched PubMed, Web of Science, Scopus, Google Scholar and articles reference lists for studies on MT2 receptor ligands in sleep, anxiety, neuropsychiatric diseases and psychopharmacology, including genetic studies on the MTNR1B gene, which encodes the melatonin MT2 receptor. Results These studies demonstrate that MT2 receptors are involved in the pathophysiology and pharmacology of sleep disorders, anxiety, depression, Alzheimer disease and pain and that selective MT2 receptor agonists show hypnotic and anxiolytic properties. Limitations Studies examining the role of MT2 receptors in psychopharmacology are still limited. Conclusion The development of novel selective MT2 receptor ligands, together with further preclinical in vivo studies, may clarify the role of this receptor in brain function and psychopharmacology. The superfamily of GPCRs has proven to be among the most successful drug targets and, consequently, MT2 receptors have great potential for pioneer drug discovery in the treatment of mental diseases for which limited therapeutic targets are currently available. PMID:23971978

  5. MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries.

    PubMed

    Tunstall, Radhika R; Shukla, Praveen; Grazul-Bilska, Anna; Sun, Chengwen; O'Rourke, Stephen T

    2011-01-01

    Previous studies from our laboratory demonstrated that melatonin inhibits nitric oxide (NO)-induced relaxation in porcine coronary arteries. The present study was designed to further characterize the mechanisms underlying this inhibitory effect of melatonin. Western immunoblot studies identified the presence of melatonin type 2 (MT(2)) receptors, but not MT(1) or MT(3) receptors, in porcine coronary arteries. Immunohistochemical analysis revealed that MT(2) receptors colocalized with α-actin in the smooth muscle cell layer. In coronary arterial rings suspended in organ chambers for isometric tension recording, melatonin (10(-7) M) inhibited relaxations induced by the exogenous NO donor sodium nitroprusside (SNP; 10(-9) to 10(-5) M) and by the α(2)-adrenoceptor agonist 5-bromo-6-[2-imidazolin-2-yl-amino]-quinoxaline (UK14,304; 10(-9) to 10(-5) M), an endothelium-dependent vasodilator. The inhibitory effect of melatonin on SNP- and UK14,304-induced relaxations was abolished in the presence of the selective MT(2) receptor antagonists 4-phenyl-2-propionamidotetralin (4P-PDOT; 10(-7) M) and luzindole (10(-7) M). In contrast to melatonin, the selective MT(3) receptor agonist 5-methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT; 10(-7) M) had no effect on the concentration-response curves to either SNP or UK14,304. Melatonin (10(-7) M) had no effect on coronary artery relaxation induced by 8-bromoguanosine 3',5'-cyclic monophosphate, but it significantly attenuated the increase in intracellular cyclic GMP levels in response to SNP (10(-5) M). This effect of melatonin was abolished in the presence of 4P-PDOT (10(-7) M). Taken together, these data support the view that melatonin acts on MT(2) receptors in coronary vascular smooth muscle cells to inhibit NO-induced increases in cyclic GMP and coronary arterial relaxation, thus demonstrating a novel function for MT(2) receptors in the vasculature.

  6. Chronic exposure to asbestos enhances TGF-β1 production in the human adult T cell leukemia virus-immortalized T cell line MT-2.

    PubMed

    Maeda, Megumi; Chen, Ying; Hayashi, Hiroaki; Kumagai-Takei, Naoko; Matsuzaki, Hidenori; Lee, Suni; Nishimura, Yasumitsu; Otsuki, Takemi

    2014-12-01

    Asbestos exposure causes various tumors such as lung cancer and malignant mesothelioma. To elucidate the immunological alteration in asbestos-related tumors, an asbestos-induced apoptosis-resistant subline (MT-2Rst) was established from a human adult T cell leukemia virus-immortalized T cell line (MT-2Org) by long-term exposure to asbestos chrysotile-B (CB). In this study, transforming growth factor-β1 (TGF-β1) knockdown using lentiviral vector-mediated RNA interference showed that MT-2Rst cells secreted increased levels of TGF-β1, and acquired resistance to TGF-β1-mediated growth inhibition. We showed that exposure of MT-2Org cells to CB activated the mitogen-activated protein kinases (MAPKs), ERK1/2, p38 and JNK1. Furthermore, TGF-β1-knockdown cells and treatment with MAPK inhibitors revealed that MT-2Rst cells secreted a high level of TGF-β1 mainly through phosphorylation of p38. However, an Annexin V assay indicated that TGF-β1 resistance in MT-2Rst cells was not directly involved in the acquisition of resistance to apoptosis that is triggered by CB exposure. The overall results demonstrate that long-term exposure of MT-2Org cells to CB induces a regulatory T cell-like phenotype, suggesting that chronic exposure to asbestos leads to a state of immune suppression.

  7. Supersymmetry Breaking, Gauge Mediation, and the LHC

    SciTech Connect

    Shih, David

    2015-04-14

    Gauge mediated SUSY breaking (GMSB) is a promising class of supersymmetric models that automatically satisfies the precision constraints. Prior work of Meade, Seiberg and Shih in 2008 established the full, model-independent parameter space of GMSB, which they called "General Gauge Mediation" (GGM). During the first half of 2010-2015, Shih and his collaborators thoroughly explored the parameter space of GGM and established many well-motivated benchmark models for use by the experimentalists at the LHC. Through their work, the current constraints on GGM from LEP, the Tevatron and the LHC were fully elucidated, together with the possible collider signatures of GMSB at the LHC. This ensured that the full discovery potential for GGM could be completely realized at the LHC.

  8. Status of LHC crab activity simulations and beam studies

    SciTech Connect

    Calaga,R.; Assman, R.; Barranco, J.; Barranco, J.; Calaga, R.; Caspers, F.; Ciapala, E.; De-Maria, R.; Koutchouk, J. P.; Linnecar, T.; Metral, E.; Morita, A.; Solyak, N.; Sun, Y.; Tomas, R.; Tuckmantel, J.; Weiler, T.; Zimmermann, F.

    2009-05-04

    The LHC crab cavity program is advancing rapidly towards a first prototype which is anticipated to be tested during the early stages of the LHC phase I upgrade and commissioning. The general project status and some aspects related to crab optics, collimation, aperture constraints, impedances, noise effects. beam transparency and machine protection critical for a safe and robust operation of LHC beams with crab cavities are addressed here.

  9. Melatonin influences somatostatin secretion from human pancreatic δ-cells via MT1 and MT2 receptors.

    PubMed

    Zibolka, Juliane; Mühlbauer, Eckhard; Peschke, Elmar

    2015-03-01

    Melatonin is an effector of the diurnal clock on pancreatic islets. The membrane receptor-transmitted inhibitory influence of melatonin on insulin secretion is well established and contrasts with the reported stimulation of glucagon release from α-cells. Virtually, nothing is known concerning the melatonin-mediated effects on islet δ-cells. Analysis of a human pancreatic δ-cell model, the cell line QGP-1, and the use of a somatostatin-specific radioimmunoassay showed that melatonin primarily has an inhibitory effect on somatostatin secretion in the physiological concentration range. In the pharmacological range, melatonin elicited slightly increased somatostatin release from δ-cells. Cyclic adenosine monophosphate (cAMP) is the major second messenger dose-dependently stimulating somatostatin secretion, in experiments employing the membrane-permeable 8-Br-cAMP. 8-Br-cyclic guanosine monophosphate proved to be of only minor relevance to somatostatin release. As the inhibitory effect of 1 nm melatonin was reversed after incubation of QGP-1 cells with the nonselective melatonin receptor antagonist luzindole, but not with the MT2-selective antagonist 4-P-PDOT (4-phenyl-2-propionamidotetraline), an involvement of the MT1 receptor can be assumed. Somatostatin release from the δ-cells at low glucose concentrations was significantly inhibited during co-incubation with 1 nm melatonin, an effect which was less pronounced at higher glucose levels. Transient expression experiments, overexpressing MT1, MT2, or a deletion variant as a control, indicated that the MT1 and not the MT2 receptor was the major transmitter of the inhibitory melatonin effect. These data point to a significant influence of melatonin on pancreatic δ-cells and on somatostatin release.

  10. Melatonin receptors MT1 and MT2 are expressed in spermatozoa from several seasonal and nonseasonal breeder species.

    PubMed

    González-Arto, Marta; Vicente-Carrillo, Alejandro; Martínez-Pastor, Felipe; Fernández-Alegre, Estela; Roca, Jordi; Miró, Jordi; Rigau, Teresa; Rodríguez-Gil, Joan E; Pérez-Pé, Rosaura; Muiño-Blanco, Teresa; Cebrián-Pérez, José A; Casao, Adriana

    2016-11-01

    Melatonin is a ubiquitous and multipurpose molecule, and one of its roles is to regulate reproduction in some seasonal mammals. Our group has previously reported the variation in the melatonin levels in ram seminal plasma along the year and identified MT1 and MT2 receptors in ram spermatozoa. The objective of this study was to elucidate whether the presence of melatonin receptors (MT1 and MT2) in the sperm plasma membrane, and melatonin in the seminal plasma is related to seasonal breeding. For this purpose, the presence of melatonin receptors and the levels of melatonin in seminal plasma have been examined in several species: donkey and stallion as long-day breeders; red deer as a wild, short-day, highly seasonal breeder (epididymal spermatozoa); bull as a conventional nonseasonal breeder; boar as a seasonal breeder under management techniques; and dog as possible a seasonal breeder not regulated by melatonin. We have detected measurable levels of melatonin in the seminal plasma of all ejaculated semen samples (from donkey, stallion, boar, bull, and dog). Also, and for the first time, we have demonstrated the presence of MT1 and MT2 melatonin receptors in the spermatozoa of all these species, regardless their type of reproduction or sperm source (ejaculated or epididymal), using indirect immunofluorescence techniques and Western blotting. Our findings suggest that melatonin and melatonin receptors may be universally distributed in the reproductive system of mammals and that the sperm melatonin receptors cells may not be necessarily related with seasonal reproduction. Furthermore, the presence of MT1 at the cytoplasmic droplet in immature ejaculated stallion spermatozoa found in one sample and epididymal red deer spermatozoa suggests that melatonin may be involved in specific functions during spermatogenesis and sperm maturation, like protecting spermatozoa from oxidative damage, this activity being mediated through these receptors. Copyright © 2016 Elsevier Inc

  11. Caenorhabditis elegans metallothionein isoform specificity--metal binding abilities and the role of histidine in CeMT1 and CeMT2.

    PubMed

    Bofill, Roger; Orihuela, Rubén; Romagosa, Míriam; Domènech, Jordi; Atrian, Sílvia; Capdevila, Mercè

    2009-12-01

    Two metallothionein (MT) isoforms have been identified in the model nematode Caenorhabditis elegans: CeMT1 and CeMT2, comprising two polypeptides that are 75 and 63 residues in length, respectively. Both isoforms encompass a conserved cysteine pattern (19 in CeMT1 and 18 in CeMT2) and, most significantly, as a result of their coordinative potential, CeMT1 includes four histidines, whereas CeMT2 has only one. In the present study, we present a comprehensive and comparative analysis of the metal [Zn(II), Cd(II) and Cu(I)] binding abilities of CeMT1 and CeMT2, performed through spectroscopic and spectrometric characterization of the recombinant metal-MT complexes synthesized for wild-type isoforms (CeMT1 and CeMT2), their separate N- and C-terminal moieties (NtCeMT1, CtCeMT1, NtCeMT2 and CtCeMT2) and a DeltaHisCeMT2 mutant. The corresponding in vitro Zn/Cd- and Zn/Cu-replacement and acidification/renaturalization processes have also been studied, as well as protein modification strategies that make it possible to identify and quantify the contribution of the histidine residues to metal coordination. Overall, the data obtained in the present study are consistent with a scenario where both isoforms exhibit a clear preference for divalent metal ion binding, rather than for Cu coordination, although this preference is more pronounced towards cadmium for CeMT2, whereas it is markedly clearer towards Zn for CeMT1. The presence of histidines in these MTs is revealed to be decisive for their coordination performance. In CeMT1, they contribute to the binding of a seventh Zn(II) ion in relation to the M(II)(6)-CeMT2 complexes, both when synthesized in the presence of supplemented Zn(II) or Cd(II). In CeMT2, the unique C-terminal histidine abolishes the Cu-thionein character that this isoform would otherwise exhibit.

  12. Safety profile of tasimelteon, a melatonin MT1 and MT2 receptor agonist: pooled safety analyses from six clinical studies.

    PubMed

    Leger, Damien; Quera-Salva, Maria-Antonia; Vecchierini, Marie-Françoise; Ogrizek, Pascale; Perry, Christina A; Dressman, Marlene A

    2015-01-01

    Tasimelteon, a novel circadian regulator, is the first product for the treatment of Non-24-hour Sleep-Wake Disorder (Non-24) approved by either the FDA or the European Medicines Agency (EMA). Tasimelteon is a potent and specific melatonin (MT1 and MT2) receptor agonist with 2 - 4 times greater affinity for the MT2 receptor. Safety was assessed in two controlled and two open-label studies in blind individuals with Non-24 and in two controlled studies of primary insomnia. Periodic assessments included collection of adverse events (AEs), laboratory testing, electrocardiograms (ECGs), vital sign monitoring, physical examinations and assessment for the potential for suicide. One study included additional assessments for endocrine function. A total of 184 blind individuals with Non-24 received tasimelteon nightly with a median exposure > 1 year. In placebo-controlled studies, 387 patients with insomnia and 42 patients with Non-24 received tasimelteon nightly for 4 - 26 weeks. The total patient years exposure for the six studies assessed here is 258.64 patient years. Discontinuations due to AEs were similar across treatment groups. Overall in the clinical studies described here, AEs attributable to tasimelteon treatment were headache, diarrhea, dry mouth, alanine aminotransferase increased, somnolence, dizziness and nightmare/abnormal dreams. There were no clinically significant differences in treatment group with ECGs, vital signs, withdrawal, endocrine function and suicidality assessments. Long-term tasimelteon administration was safe and well-tolerated. This is supported by placebo-controlled data in both Non-24 and insomnia patients.

  13. Ramelteon, a selective MT1/MT2 receptor agonist, suppresses the proliferation and invasiveness of endometrial cancer cells.

    PubMed

    Osanai, Kiyono; Kobayashi, Yoichi; Otsu, Masahiro; Izawa, Tomoko; Sakai, Keiji; Iwashita, Mitsutoshi

    2017-07-01

    The incidence of endometrial cancer is increasing, making it the fifth most common cancer worldwide. To date, however, there is no standard therapy for patients with recurrent endometrial cancer. Melatonin, a hormone secreted by the pineal gland, has been shown to have anti-tumor effects in various tumor types. Although melatonin is available as a supplement, it has not been approved for cancer treatment. Ramelteon, a selective melatonin receptor type 1 and 2 (MT1/MT2) receptor agonist, has been approved to treat sleep disorders, suggesting that ramelteon may be effective in the treatment of endometrial cancer. To determine whether this agent may be effective in the treatment of endometrial cancer, this study investigated the ability of ramelteon to suppress the proliferation and invasiveness of HHUA cells, an estrogen receptor-positive endometrial cancer cell line. Ramelteon at 10(-8) M maximally suppressed the proliferation of HHUA cells, reducing the percentage of Ki-67 positive proliferating cells. This effect was completely blocked by luzindole, a MT1/MT2 receptor antagonist. Furthermore, ramelteon inhibited HHUA cell invasion and reduced the expression of the MMP-2 and MMP-9 genes. These results suggested that ramelteon may be a candidate for the treatment of recurrent endometrial cancer, with activity similar to that of melatonin.

  14. A comparison between monoclonal antibody MT2 and immunoglobulin staining in the differential diagnosis of follicular lymphoid proliferations in routinely fixed wax-embedded biopsies.

    PubMed Central

    Norton, A. J.; Rivas, C.; Isaacson, P. G.

    1989-01-01

    Monoclonal antibody MT2 and anti-immunoglobulins were tested for their ability to discriminate between reactive lymphoid hyperplasia and follicular lymphoma (centroblastic/centrocytic; CB/CC) informalin-fixed and wax-embedded biopsies. The streptavidin biotin peroxidase complex method was used. In 46 of 49 cases of reactive follicular hyperplasia the follicle center cells were unstained by MT2 whereas the mantle zone B cells and interfollicular T cells were positive. In three reactive cases up to 30% of follicle center cells also were stained. In contrast, more than 50% of neoplastic follicle center cells were stained by MT2 in 27 of 62 cases of CB/CC, and light chain restriction was shown in 52 of 62 cases. MT2 staining and/or light chain restriction was seen in 57 of 62 cases. In 106 further cases of non-Hodgkin's lymphoma, MT2 was positive in 59 of 77 B cell lymphomas and 3 of 29 T cell lymphomas. Although not a B cell specific reagent, MT2 is useful in the differential diagnosis of reactive vs. neoplastic follicular lymphoid proliferations but is less sensitive than immunoglobulin stains. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 PMID:2464283

  15. Strong dynamics at the LHC

    NASA Astrophysics Data System (ADS)

    Ittisamai, Pawin

    The limitations of the Standard Model of particle physics, despite its being a well-established theory, have prompted various proposals for new physics capable of addressing its shortcomings. The particular issue to be explored here is the mechanism of electroweak symmetry breaking, the probing of which lies within the TeV-scale physics accessible to the Large Hadron Collider (LHC). This thesis focuses on the phenomenology of a class of models featuring a dynamical breaking of the electroweak symmetry via strong dynamics. Consequences of recent experiments and aspects of near-future experiments are presented. We study the implications of the LHC Higgs searches available at the time the related journal article was written for technicolor models that feature colored technifermions. Then we discuss the properties of a technicolor model featuring strong-top dynamics that is viable for explaining the recently discovered boson of mass 126 GeV. We introduce a novel method of characterizing the color structure of a new massive vector boson, often predicted in various new physics models, using information that will be promptly available if it is discovered in the near-future experiments at the LHC. We generalize the idea for more realistic models where a vector boson has flavor non-universal couplings to quarks. Finally, we discuss the possibilities of probing the chiral structure of a new color-octet vector boson.

  16. Supersymmetry At LHC

    SciTech Connect

    Khalil, Shaaban

    2008-04-21

    One of the main motivation of the experiments at the Large Hadron Collider (LHC), scheduled to start around 2006, is to search for supersymmetric particles. The region of the parameter space of the minimal supersymmetric standard model, where supersymmetry can be discovered is investigated. We show that if supersymmetry exists at electroweak scale, it would be easy to find signals for it at the LHC. If the LHC does find supersymmetry, this would be one of the greatest achievements in the history of theoretical physics.

  17. Conditions required for the stimulation of bioluminescence activity of the genetically engineered bacteria, P. putida mt-2 KG1206, preserved by deep-freezing.

    PubMed

    Ko, K S; Kong, In Chul

    2009-03-15

    Herein the conditions required for the stimulation of bioluminescence activity in a genetically engineered strain of Pseudomonas putida mt-2 KG1206, containing the intact TOL plasmid and a constructed plasmid with the P(m)-lux gene, are reported upon. Both sodium lactate (SL) and potassium nitrate (KNO(3)) were able to stimulate the bioluminescence activity, but a greater increase was observed with nitrogen amendment. This selected stimulant was then tested on reconstituted cells that had been preserved by deep-freezing and mixed with pure inducer solution or groundwater samples. The stimulation of bioluminescence activities for deep-frozen strain was in the range of 101-238% of the control. The effect of KNO(3) was found to be dependent on the type of inducers used and the cell conditions. In general, high bioluminescence activity was observed with groundwater samples, contaminated with high inducer compounds. However, no significant correlation was observed between the bioluminescence intensity and the total inducer concentration in the environmental samples contaminated with complex mixtures with inducers. These results should be useful when other recombinant bioluminescence strains are to be used for environmental monitoring. Overall, the results of this study demonstrate the stimulant conditions for the bioluminescence activity of genetically engineered bacteria, and suggest the potential for preliminary application of this deep-frozen engineered strain in a field-ready bioassay to conveniently detect or monitor a specific group of environmental contaminants.

  18. Application of the freeze-dried bioluminescent bioreporter Pseudomonas putida mt-2 KG1206 to the biomonitoring of groundwater samples from monitoring wells near gasoline leakage sites.

    PubMed

    Ko, Kyung-Seok; Kong, In Chul

    2017-02-01

    This study examined the applicability of a freeze-dried bioluminescent bioreporter, Pseudomonas putida mt-2 KG1206 (called KG1206), to the biomonitoring of groundwater samples. Samples were collected from the monitoring wells of gas station tanks or old pipeline leakage sites in Korea. In general, the freeze-dried strain in the presence of pure inducer chemicals showed low bioluminescence activity and a different activity order compared with that of the subcultured strain. The effects of KNO3 as a bioluminescence stimulant were observed on the pure inducers and groundwater samples. The stimulation rates varied according to the type of inducers and samples, ranging from 2.2 to 20.5 times (for pure inducers) and from 1.1 to 11 times (for groundwater samples) the total bioluminescence of the control. No considerable correlations were observed between the bioluminescence intensity of the freeze-dried strain and the inducer concentrations in the samples (R (2) < 0.1344). However, samples without a high methyl tertiary butyl ether (MTBE) level and those from the gas station leakage site showed reasonable correlations with the bioluminescence activity with R (2) values of 0.3551 and 0.4131, respectively. These results highlight the potential of using freeze-dried bioluminescent bacteria as a rapid, simple, and portable tool for the preliminary biomonitoring of specific pollutants at contaminated sites.

  19. ScMT2-1-3, a metallothionein gene of sugarcane, plays an important role in the regulation of heavy metal tolerance/accumulation.

    PubMed

    Guo, Jinlong; Xu, Liping; Su, Yachun; Wang, Hengbo; Gao, Shiwu; Xu, Jingsheng; Que, Youxiong

    2013-01-01

    Plant metallothioneins (MTs), which are cysteine-rich, low-molecular-weight, and metal-binding proteins, play important roles in detoxification, metal ion homeostasis, and metal transport adjustment. In this study, a novel metallothionein gene, designated as ScMT2-1-3 (GenBank Accession number JQ627644), was identified from sugarcane. ScMT2-1-3 was 700 bp long, including a 240 bp open reading frame (ORF) encoding 79 amino acid residues. A His-tagged ScMT2-1-3 protein was successfully expressed in Escherichia coli system which had increased the host cell's tolerance to Cd(2+), Cu(2+), PEG, and NaCl. The expression of ScMT2-1-3 was upregulated under Cu(2+) stress but downregulated under Cd(2+) stress. Real-time qPCR demonstrated that the expression levels of ScMT2-1-3 in bud and root were over 14 times higher than those in stem and leaf, respectively. Thus, both the E. coli assay and sugarcane plantlets assay suggested that ScMT2-1-3 is significantly involved in the copper detoxification and storage in the cell, but its functional mechanism in cadmium detoxification and storage in sugarcane cells needs more testification though its expressed protein could obviously increase the host E. coli cell's tolerance to Cd(2+). ScMT2-1-3 constitutes thus a new interesting candidate for elucidating the molecular mechanisms of MTs-implied plant heavy metal tolerance/accumulation and for developing sugarcane phytoremediator varieties.

  20. Cloning and characterization of HbMT2a, a metallothionein gene from Hevea brasiliensis Muell. Arg differently responds to abiotic stress and heavy metals.

    PubMed

    Li, Yan; Chen, Yue Yi; Yang, Shu Guang; Tian, Wei Min

    2015-05-22

    Metallothioneins (MTs) are of low molecular mass, cysteine-rich proteins. They play an important role in the detoxification of heavy metals and homeostasis of intracellular metal ions, and protecting against intracellular oxidative damages. In this study a full-length cDNA of type 2 plant metallothioneins, HbMT2a, was isolated from 25 mM Polyethyleneglycol (PEG) stressed leaves of Hevea brasiliensis by RACE. The HbMT2a was 372bp in length and had a 237bp open reading frame (ORF) encoding for a protein of 78 amino acid residues with molecular mass of 7.772 kDa. The expression of HbMT2a in the detached leaves of rubber tree clone RY7-33-97 was up-regulated by Me-JA, ABA, PEG, H2O2, Cu(2+) and Zn(2+), but down-regulated by water. The role of HbMT2a protein in protecting against metal toxicity was demonstrated in vitro. PET-28a-HbMT2-beared Escherichia coli. Differential expression of HbMT2a upon treatment with 10 °C was observed in the detached leaves of rubber tree clone 93-114 which is cold-resistant and Reken501 which is cold-sensitive. The expression patterns of HbMT2a in the two rubber tree clones may be ascribed to a change in the level of endogenous H2O2.

  1. The LHC Experiments

    ScienceCinema

    Lincoln, Don

    2016-07-12

    The Large Hadron Collider or LHC is the world’s biggest particle accelerator, but it can only get particles moving very quickly. To make measurements, scientists must employ particle detectors. There are four big detectors at the LHC: ALICE, ATLAS, CMS, and LHCb. In this video, Fermilab’s Dr. Don Lincoln introduces us to these detectors and gives us an idea of each one’s capabilities.

  2. The LHC Experiments

    SciTech Connect

    Lincoln, Don

    2015-03-11

    The Large Hadron Collider or LHC is the world’s biggest particle accelerator, but it can only get particles moving very quickly. To make measurements, scientists must employ particle detectors. There are four big detectors at the LHC: ALICE, ATLAS, CMS, and LHCb. In this video, Fermilab’s Dr. Don Lincoln introduces us to these detectors and gives us an idea of each one’s capabilities.

  3. The ALICE experiment at the LHC

    NASA Astrophysics Data System (ADS)

    Crochet, P.

    2008-12-01

    After a general introduction on the Quark Gluon Plasma and a short overview of the experimental results obtained so far with heavy-ion collisions at the SPS and at the RHIC, the physics goals of the ALICE experiment at the LHC are presented.

  4. New melatonin (MT1/MT2) ligands: design and synthesis of (8,9-dihydro-7H-furo[3,2-f]chromen-1-yl) derivatives.

    PubMed

    Landagaray, Elodie; Ettaoussi, Mohamed; Leclerc, Véronique; Traoré, Balla; Perez, Valérie; Nosjean, Olivier; Boutin, Jean A; Caignard, Daniel-Henri; Delagrange, Philippe; Berthelot, Pascal; Yous, Saïd

    2014-02-01

    Herein we describe the synthesis of novel tricyclic analogues issued from the rigidification of the methoxy group of the benzofuranic analogue of melatonin as MT1 and MT2 ligands. Most of the synthesized compounds displayed high binding affinities at MT1 and MT2 receptors subtypes. Compound 6b (MT1, Ki=0.07nM; MT2, Ki=0.08nM) exhibited with the vinyl 6c and allyl 6d the most interesting derivatives of this series. Functional activity of these compounds showed full agonist activity with EC50 in the nanomolar range. Compounds 6a (EC50=0.8nM and Emax=98%) and 6b (EC50=0.2nM and Emax=121%) exhibited good pharmacological profiles. Copyright © 2013 Elsevier Ltd. All rights reserved.

  5. LHC Olympics: Advanced Analysis Techniques

    NASA Astrophysics Data System (ADS)

    Armour, Kyle; Larkoski, Andrew; Gray, Amanda; Ventura, Dan; Walsh, Jon; Schabinger, Rob

    2006-05-01

    The LHC Olympics is a series of workshop aimed at encouraging theorists and experimentalists to prepare for the soon-to-be-online Large Hadron Collider in Geneva, Switzerland. One aspect of the LHC Olympics program consists of the study of simulated data sets which represent various possible new physics signals as they would be seen in LHC detectors. Through this exercise, LHC Olympians learn the phenomenology of possible new physics models and gain experience in analyzing LHC data. Additionally, the LHC Olympics encourages discussion between theorists and experimentalists, and through this collaboration new techniques could be developed. The University of Washington LHC Olympics group consists of several first-year graduate and senior undergraduate students, in both theoretical and experimental particle physics. Presented here is a discussion of some of the more advanced techniques used and the recent results of one such LHC Olympics study.

  6. Regulation of the degradative pathway enzymes coded for by the TOL plasmid (pWWO) from Pseudomonas putida mt-2.

    PubMed Central

    Worsey, M J; Franklin, F C; Williams, P A

    1978-01-01

    Pseudomonas putida mt-2 carries a plasmid (TOL, pWWO) which codes for a single set of enzymes responsible for the catabolism of toluene and m- and p-xylene to central metabolites by way of benzoate and m- and p-toluate, respectively, and subsequently by a meta cleavage pathway. Characterization of strains with mutations in structural genes of this pathway demonstrates that the inducers of the enzymes responsible for further degradation of m-toluate include m-xylene, m-methylbenzyl alcohol, and m-toluate, whereas the inducers of the enzymes responsible for oxidation of m-xylene to m-toluate include m-xylene and m-methylbenzyl alcohol but not m-toluate. A regulatory mutant is described in which m-xylene and m-methylbenzyl alcohol no longer induce any of the pathway enzymes, but m-toluate is still able to induce the enzymes responsible for its own degradation. Among revertants of this mutant are some strains in which all the enzymes are expressed constitutively and are not further induced by m-xylene. A model is proposed for the regulation of the pathway in which the enzymes are in two regulatory blocks, which are under the control of two regulator gene products. The model is essentially the same as proposed earlier for the regulation of the isofunctional pathway on the TOL20 plasmid from P. putida MT20. PMID:659369

  7. Effect of silver nanoparticles and silver ions on growth and adaptive response mechanisms of Pseudomonas putida mt-2.

    PubMed

    Hachicho, Nancy; Hoffmann, Philipp; Ahlert, Kristin; Heipieper, Hermann J

    2014-06-01

    The distribution and use of nanoparticles increased rapidly during the last years, while the knowledge about mode of action, ecological tolerance and biodegradability of these chemicals is still insufficient. The effect of silver nanoparticles (AgNP) and free silver ions (Ag(+) , AgNO3 ) on Pseudomonas putida mt-2 as one of the best described bacterial strains for stress response were investigated. The effective concentration (EC50) causing 50% growth inhibition for AgNP was about 250 mg L(-1) , whereas this was only 0.175 mg L(-1) for AgNO3 . However, when calculating the amount of free silver ions released from AgNP both tested compounds showed very similar results. Therefore, the antibacterial activity of AgNP can be explained and reduced, respectively, to the amount of silver ions released from the nanoparticles. Both tested compounds showed a strong activation of the unique membrane adaptive response of Pseudomonas strains, the cis-trans isomerization of unsaturated fatty acids, whereas another important adaptive response of these bacteria, changes in cell surface hydrophobicity, measured as water contact angle, was not activated. These results are important informations for the estimation of environmental tolerance of newly developed, active ingredients like silver nanoparticles. © 2014 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved.

  8. Exogenous melatonin reduced blood pressure in late-term ovine fetus via MT1/MT2 receptor pathways.

    PubMed

    Tao, Jianying; Lv, Juanxiu; Li, Weisheng; Zhang, Pengjie; Mao, Caiping; Xu, Zhice

    2016-09-01

    Melatonin is involved in the regulation of blood pressure through the receptor dependent or independent route. However, the effect of melatonin on fetal blood pressure is unknown. This study investigated the effect of melatonin on blood pressure of the late-term ovine fetus in utero. Melatonin and/or antagonists were intravenously administered into the fetuses. Mean arterial pressure and heart rate were recorded. Fetal blood samples were analyzed for biochemical parameters and hormones, including cortisol, angiotensin I, angiotensin II, aldosterone, atrial natriuretic peptide, corticotrophin-releasing hormone, adrenocorticotropic hormone, and endothelin. Fetal blood pressure was decreased following administration of melatonin, whereas it was increased following administration of luzindole, but not prazosin. Plasma level of endothelin was decreased by melatonin, which was blocked by luzindole. Our study suggested that melatonin reduced fetal blood pressure via MT1/MT2 receptors and possibly involving release of endothelin. Copyright © 2016 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

  9. Metabolism of toluene and xylenes by Pseudomonas (putida (arvilla) mt-2: evidence for a new function of the TOL plasmid.

    PubMed Central

    Worsey, M J; Williams, P A

    1975-01-01

    Pseudomonas putida (arvilla) mt-2 carries genes for the catabolism of toluene, m-xylene, and p-xylene on a transmissible plasmid, TOL. These compounds are degraded by oxidation of one of the methyl substituents via the corresponding alcohols and aldehydes to benzoate and m- and p-toluates, respectively, which are then further metabolised by the meta pathway, also coded for by the TOL plasmid. The specificities of the benzyl alcohol dehydrogenase and the benzaldehyde dehydrogenase for their three respective substrates are independent of the carbon source used for growth, suggesting that a single set of nonspecific enzymes is responsible for the dissimilation of the breakdown products of toluene and m- and p-xylene. Benzyl alcohol dehydrogenase and benzaldehyde dehydrogenase are coincidently and possible coordinately induced by toluene and the xylenes, and by the corresponding alcohols and aldehydes. They are not induced in cells grown on m-toluate but catechol 2,3-oxygenase can be induced by m-xylene. PMID:1176436

  10. Molecular cloning and pharmacological characterization of monkey MT1 and MT2 melatonin receptors showing high affinity for the agonist ramelteon.

    PubMed

    Nishiyama, Keiji; Shintani, Yasushi; Hirai, Keisuke; Yoshikubo, Shin-ichi

    2009-09-01

    Melatonin receptor agonists such as melatonin and ramelteon [(S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethyl]-propionamide; TAK-375] have sleep-promoting effects in humans. In preclinical models, these effects are more similar to those observed in monkeys than in other species. However, in contrast to the human melatonin receptors, the pharmacological characteristics of the monkey melatonin receptors have yet to be elucidated. In this study, we cloned the cynomolgus monkey MT(1) and MT(2) melatonin receptors based on rhesus monkey genome sequences and then characterized the monkey melatonin receptors and compared their pharmacological properties with those of the human homologs. The overall amino acid sequences of the monkey MT(1) and MT(2) melatonin receptors showed high homology to the human MT(1) (95%) and MT(2) (96%) receptors, respectively. Saturation binding experiments with 2-[(125)I]iodomelatonin revealed that the dissociation constants (K(d)) for the monkey MT(1) and MT(2) melatonin receptors were 19.9 and 70.4 pM, respectively. In ligand competition assays using 2-[(125)I]iodomelatonin, ramelteon displayed approximately 3- to 7-fold higher affinities than melatonin for the recombinant monkey MT(1) and MT(2) melatonin receptors and monkey suprachiasmatic nucleus membranes. This higher affinity of ramelteon compared with melatonin has also been observed in human melatonin receptors. Furthermore, ramelteon inhibited pituitary adenylate cyclase-activating polypeptide-27-stimulated cAMP production with higher potency than melatonin. In conclusion, this information will help us to understand the pharmacological effects of melatonin receptor agonists in monkeys.

  11. The TOL network of Pseudomonas putida mt-2 processes multiple environmental inputs into a narrow response space.

    PubMed

    Silva-Rocha, Rafael; de Lorenzo, Víctor

    2013-01-01

    The TOL system encoded by plasmid pWW0 of Pseudomonas putida mt-2 is able to sense a large number of both exogenous and endogenous signals as inputs for the genetic and metabolic circuit that determines the biodegradation of m-xylene. However, whether the enormous combinatorial space of inputs is translated into an equally variable response landscape or is processed into very few outcomes remains unclear. To address this question, we set out to define the number of states that can be obtained by a network of a given set of genes under the control of a specified regulatory circuit that is exposed to all possible combinations of inputs. To this end, the TOL network and its regulatory wiring were formalized as a synchronous logic Boolean circuit that had 10 signals (i.e. pathway substrates, temperature, sugars, amino acids, metabolic regimes and global regulators) as possible inputs. The analysis of the attractors of the circuit using a satisfiability (SAT) algorithm revealed that only eight transcriptional states are reached in response to the 1024 possible combinations of stimuli. The experimental validation resulted in a refinement of the model through the addition of a previously unknown interaction that controls the meta catabolic pathway. The full induction of the two xyl operons occurred with only 1.6% of the input combinations, which suggests that the architecture of the network allows the expression of the xyl genes only under a very narrow range of conditions. These data not only explain much of the unusual layout of the TOL circuit but also strengthen the view of the regulatory circuits of environmental bacteria as digital decision-making devices. © 2012 Society for Applied Microbiology and Blackwell Publishing Ltd.

  12. Scenarios for sLHC and vLHC

    NASA Astrophysics Data System (ADS)

    Scandale, W.; Zimmermann, F.

    2008-03-01

    The projected lifetime of the LHC low-beta quadrupoles and evolution of the statistical error halving time call for an LHC luminosity upgrade by the middle of the coming decade. In the framework of the EU CARE-HHH network, two scenarios have been developed for increasing the LHC peak luminosity by a factor 10, to 10 cms ("sLHC"). Both scenarios imply a rebuilding of the high-luminosity interaction regions (IRs) in combination with a consistent change of beam parameters. However, their respective features, bunch structures, IR layouts, merits and challenges differ substantially. In either scenario luminosity leveling during a store would be advantageous for the physics experiments. Longer-term R&D efforts are devoted to a higher-energy hadron collider ("vLHC"), which could be realized on a green field or as a later and more radical LHC upgrade.

  13. LHC Nobel Symposium Proceedings

    NASA Astrophysics Data System (ADS)

    Ekelöf, Tord

    2013-12-01

    In the summer of 2012, a great discovery emerged at the Large Hadron Collider (LHC) at CERN in Geneva. A plethora of new precision data had already by then been collected by the ATLAS and CMS experiments at LHC, providing further extensive support for the validity of the Standard Model of particle physics. But what now appeared was the first evidence for what was not only the last unverified prediction of the Standard Model, but also perhaps the most decisive one: the prediction made already in 1964 of a unique scalar boson required by the theory of François Englert and Peter Higgs on how fundamental particles acquire mass. At that moment in 2012, it seemed particularly appropriate to start planning a gathering of world experts in particle physics to take stock of the situation and try to answer the challenging question: what next? By May 2013, when the LHC Nobel Symposium was held at the Krusenberg Mansion outside Uppsala in Sweden, the first signs of a great discovery had already turned into fully convincing experimental evidence for the existence of a scalar boson of mass about 125 GeV, having properties compatible with the 50-year-old prediction. And in October 2013, the evidence was deemed so convincing that the Swedish Royal Academy of Sciences awarded the Nobel Prize in Physics to Englert and Higgs for their pioneering work. At the same time the search at the LHC for other particles, beyond those predicted by the Standard Model, with heavier masses up to—and in some cases beyond—1 TeV, had provided no positive result. The triumph of the Standard Model seems resounding, in particular because the mass of the discovered scalar boson is such that, when identified with the Higgs boson, the Standard Model is able to provide predictions at energies as high as the Planck mass, although at the price of accepting that the vacuum would be metastable. However, even if there were some feelings of triumph, the ambience at the LHC Nobel Symposium was more one of

  14. Private Higgs at the Lhc

    NASA Astrophysics Data System (ADS)

    Bentov, Yoni; Zee, A.

    2013-11-01

    We study the LHC phenomenology of a general class of "Private Higgs" (PH) models, in which fermions obtain their masses from their own Higgs doublets with {O}(1) Yukawa couplings, and the mass hierarchy is translated into a dynamical chain of vacuum expectation values. This is accomplished by introducing a number of light gauge-singlet scalars, the "darkons," some of which could play the role of dark matter. These models allow for substantial modifications to the decays of the lightest Higgs boson, for instance through mixing with TeV-scale PH fields and light darkons: in particular, one could accommodate {O}(10%) flavor-uncorrelated deviations from the SM hf\\bar f vertices with TeV-scale degrees of freedom. We also discuss a new implementation of the PH framework, in which the quark and neutrino mixing angles arise as one-loop corrections to the leading order picture.

  15. LHC forward physics

    SciTech Connect

    Akiba, K.; Akbiyik, M.; Albrow, M.; Arneodo, M.; Avati, V.; Baechler, J.; Baillie, O. Villalobos; Bartalini, P.; Bartels, J.; Baur, S.; Baus, C.; Beaumont, W.; Behrens, U.; Berge, D.; Berretti, M.; Bossini, E.; Boussarie, R.; Brodsky, S.; Broz, M.; Bruschi, M.; Bussey, P.; Byczynski, W.; Noris, J. C. Cabanillas; Villar, E. Calvo; Campbell, A.; Caporale, F.; Carvalho, W.; Chachamis, G.; Chapon, E.; Cheshkov, C.; Chwastowski, J.; Ciesielski, R.; Chinellato, D.; Cisek, A.; Coco, V.; Collins, P.; Contreras, J. G.; Cox, B.; Damiao, D. de Jesus; Davis, P.; Deile, M.; D’Enterria, D.; Druzhkin, D.; Ducloué, B.; Dumps, R.; Dzhelyadin, R.; Dziurdzia, P.; Eliachevitch, M.; Fassnacht, P.; Ferro, F.; Fichet, S.; Figueiredo, D.; Field, B.; Finogeev, D.; Fiore, R.; Forshaw, J.; Medina, A. Gago; Gallinaro, M.; Granik, A.; Gersdorff, G. von; Giani, S.; Golec-Biernat, K.; Goncalves, V. P.; Göttlicher, P.; Goulianos, K.; Grosslord, J-Y; Harland-Lang, L. A.; Haevermaet, H. Van; Hentschinski, M.; Engel, R.; Corral, G. Herrera; Hollar, J.; Huertas, L.; Johnson, D.; Katkov, I.; Kepka, O.; Khakzad, M.; Kheyn, L.; Khachatryan, V.; Khoze, V. A.; Klein, S.; Klundert, M. van; Krauss, F.; Kurepin, A.; Kurepin, N.; Kutak, K.; Kuznetsova, E.; Latino, G.; Lebiedowicz, P.; Lenzi, B.; Lewandowska, E.; Liu, S.; Luszczak, A.; Luszczak, M.; Madrigal, J. D.; Mangano, M.; Marcone, Z.; Marquet, C.; Martin, A. D.; Martin, T.; Hernandez, M. I. Martinez; Martins, C.; Mayer, C.; Nulty, R. Mc; Mechelen, P. Van; Macula, R.; Costa, E. Melo da; Mertzimekis, T.; Mesropian, C.; Mieskolainen, M.; Minafra, N.; Monzon, I. L.; Mundim, L.; Murdaca, B.; Murray, M.; Niewiadowski, H.; Nystrand, J.; Oliveira, E. G. de; Orava, R.; Ostapchenko, S.; Osterberg, K.; Panagiotou, A.; Papa, A.; Pasechnik, R.; Peitzmann, T.; Moreno, L. A. Perez; Pierog, T.; Pinfold, J.; Poghosyan, M.; Pol, M. E.; Prado, W.; Popov, V.; Rangel, M.; Reshetin, A.; Revol, J-P; Rijssenbeek, M.; Rodriguez, M.; Roland, B.; Royon, C.; Ruspa, M.; Ryskin, M.; Vera, A. Sabio; Safronov, G.; Sako, T.; Schindler, H.; Salek, D.; Safarik, K.; Saimpert, M.; Santoro, A.; Schicker, R.; Seger, J.; Sen, S.; Shabanov, A.; Schafer, W.; Silveira, G. Gil Da; Skands, P.; Soluk, R.; Spilbeeck, A. van; Staszewski, R.; Stevenson, S.; Stirling, W. J.; Strikman, M.; Szczurek, A.; Szymanowski, L.; Takaki, J. D. Tapia; Tasevsky, M.; Taesoo, K.; Thomas, C.; Torres, S. R.; Tricomi, A.; Trzebinski, M.; Tsybychev, D.; Turini, N.; Ulrich, R.; Usenko, E.; Varela, J.; Vetere, M. Lo; Tello, A. Villatoro; Pereira, A. Vilela; Volyanskyy, D.; Wallon, S.; Wilkinson, G.; Wöhrmann, H.; Zapp, K. C.; Zoccarato, Y.

    2016-10-17

    The goal of this report is to give a comprehensive overview of the rich field of forward physics, with a special attention to the topics that can be studied at the LHC. The report starts presenting a selection of the Monte Carlo simulation tools currently available, chapter 2, then enters the rich phenomenology of QCD at low, chapter 3, and high, chapter 4, momentum transfer, while the unique scattering conditions of central exclusive production are analyzed in chapter 5. The last two experimental topics, Cosmic Ray and Heavy Ion physics are presented in the chapter 6 and 7 respectively. Chapter 8 is dedicated to the BFKL dynamics, multiparton interactions, and saturation. Here, the report ends with an overview of the forward detectors at LHC. Each chapter is correlated with a comprehensive bibliography, attempting to provide to the interested reader with a wide opportunity for further studies.

  16. LHC forward physics

    DOE PAGES

    Akiba, K.; Akbiyik, M.; Albrow, M.; ...

    2016-10-17

    The goal of this report is to give a comprehensive overview of the rich field of forward physics, with a special attention to the topics that can be studied at the LHC. The report starts presenting a selection of the Monte Carlo simulation tools currently available, chapter 2, then enters the rich phenomenology of QCD at low, chapter 3, and high, chapter 4, momentum transfer, while the unique scattering conditions of central exclusive production are analyzed in chapter 5. The last two experimental topics, Cosmic Ray and Heavy Ion physics are presented in the chapter 6 and 7 respectively. Chaptermore » 8 is dedicated to the BFKL dynamics, multiparton interactions, and saturation. Here, the report ends with an overview of the forward detectors at LHC. Each chapter is correlated with a comprehensive bibliography, attempting to provide to the interested reader with a wide opportunity for further studies.« less

  17. LHC forward physics

    NASA Astrophysics Data System (ADS)

    Akiba, K.; Akbiyik, M.; Albrow, M.; Arneodo, M.; Avati, V.; Baechler, J.; Villalobos Baillie, O.; Bartalini, P.; Bartels, J.; Baur, S.; Baus, C.; Beaumont, W.; Behrens, U.; Berge, D.; Berretti, M.; Bossini, E.; Boussarie, R.; Brodsky, S.; Broz, M.; Bruschi, M.; Bussey, P.; Byczynski, W.; Cabanillas Noris, J. C.; Calvo Villar, E.; Campbell, A.; Caporale, F.; Carvalho, W.; Chachamis, G.; Chapon, E.; Cheshkov, C.; Chwastowski, J.; Ciesielski, R.; Chinellato, D.; Cisek, A.; Coco, V.; Collins, P.; Contreras, J. G.; Cox, B.; Damiao, D. de Jesus; Davis, P.; Deile, M.; D'Enterria, D.; Druzhkin, D.; Ducloué, B.; Dumps, R.; Dzhelyadin, R.; Dziurdzia, P.; Eliachevitch, M.; Fassnacht, P.; Ferro, F.; Fichet, S.; Figueiredo, D.; Field, B.; Finogeev, D.; Fiore, R.; Forshaw, J.; Gago Medina, A.; Gallinaro, M.; Granik, A.; von Gersdorff, G.; Giani, S.; Golec-Biernat, K.; Goncalves, V. P.; Göttlicher, P.; Goulianos, K.; Grosslord, J.-Y.; Harland-Lang, L. A.; Van Haevermaet, H.; Hentschinski, M.; Engel, R.; Herrera Corral, G.; Hollar, J.; Huertas, L.; Johnson, D.; Katkov, I.; Kepka, O.; Khakzad, M.; Kheyn, L.; Khachatryan, V.; Khoze, V. A.; Klein, S.; van Klundert, M.; Krauss, F.; Kurepin, A.; Kurepin, N.; Kutak, K.; Kuznetsova, E.; Latino, G.; Lebiedowicz, P.; Lenzi, B.; Lewandowska, E.; Liu, S.; Luszczak, A.; Luszczak, M.; Madrigal, J. D.; Mangano, M.; Marcone, Z.; Marquet, C.; Martin, A. D.; Martin, T.; Martinez Hernandez, M. I.; Martins, C.; Mayer, C.; McNulty, R.; Van Mechelen, P.; Macula, R.; Melo da Costa, E.; Mertzimekis, T.; Mesropian, C.; Mieskolainen, M.; Minafra, N.; Monzon, I. L.; Mundim, L.; Murdaca, B.; Murray, M.; Niewiadowski, H.; Nystrand, J.; de Oliveira, E. G.; Orava, R.; Ostapchenko, S.; Osterberg, K.; Panagiotou, A.; Papa, A.; Pasechnik, R.; Peitzmann, T.; Perez Moreno, L. A.; Pierog, T.; Pinfold, J.; Poghosyan, M.; Pol, M. E.; Prado, W.; Popov, V.; Rangel, M.; Reshetin, A.; Revol, J.-P.; Rijssenbeek, M.; Rodriguez, M.; Roland, B.; Royon, C.; Ruspa, M.; Ryskin, M.; Sabio Vera, A.; Safronov, G.; Sako, T.; Schindler, H.; Salek, D.; Safarik, K.; Saimpert, M.; Santoro, A.; Schicker, R.; Seger, J.; Sen, S.; Shabanov, A.; Schafer, W.; Gil Da Silveira, G.; Skands, P.; Soluk, R.; van Spilbeeck, A.; Staszewski, R.; Stevenson, S.; Stirling, W. J.; Strikman, M.; Szczurek, A.; Szymanowski, L.; Tapia Takaki, J. D.; Tasevsky, M.; Taesoo, K.; Thomas, C.; Torres, S. R.; Tricomi, A.; Trzebinski, M.; Tsybychev, D.; Turini, N.; Ulrich, R.; Usenko, E.; Varela, J.; Lo Vetere, M.; Villatoro Tello, A.; Vilela Pereira, A.; Volyanskyy, D.; Wallon, S.; Wilkinson, G.; Wöhrmann, H.; Zapp, K. C.; Zoccarato, Y.

    2016-11-01

    The goal of this report is to give a comprehensive overview of the rich field of forward physics, with a special attention to the topics that can be studied at the LHC. The report starts presenting a selection of the Monte Carlo simulation tools currently available, chapter 2, then enters the rich phenomenology of QCD at low, chapter 3, and high, chapter 4, momentum transfer, while the unique scattering conditions of central exclusive production are analyzed in chapter 5. The last two experimental topics, Cosmic Ray and Heavy Ion physics are presented in the chapter 6 and 7 respectively. Chapter 8 is dedicated to the BFKL dynamics, multiparton interactions, and saturation. The report ends with an overview of the forward detectors at LHC. Each chapter is correlated with a comprehensive bibliography, attempting to provide to the interested reader with a wide opportunity for further studies.

  18. LHC forward physics

    SciTech Connect

    Cartiglia, N.; Royon, C.

    2015-10-02

    The goal of this report is to give a comprehensive overview of the rich field of forward physics, with a special attention to the topics that can be studied at the LHC. The report starts presenting a selection of the Monte Carlo simulation tools currently available, chapter 2, then enters the rich phenomenology of QCD at low, chapter 3, and high, chapter 4, momentum transfer, while the unique scattering conditions of central exclusive production are analyzed in chapter 5. The last two experimental topics, Cosmic Ray and Heavy Ion physics are presented in the chapter 6 and 7 respectively. Chapter 8 is dedicated to the BFKL dynamics, multiparton interactions, and saturation. The report ends with an overview of the forward detectors at LHC. Each chapter is correlated with a comprehensive bibliography, attempting to provide to the interested reader with a wide opportunity for further studies.

  19. Successful graft of HTLV-I-transformed human T-cells (MT-2) in severe combined immunodeficiency mice treated with anti-asialo GM-1 antibody.

    PubMed

    Ishihara, S; Tachibana, N; Okayama, A; Murai, K; Tsuda, K; Mueller, N

    1992-04-01

    To develop an experimental model of adult T-cell leukemia/lymphoma in small animals, severe combined immunodeficiency (SCID) mice treated with anti-asialo GM-1 antibody were inoculated with MT-2 cells, a cell line transformed by the human T-cell leukemia virus (HTLV-I). Three mice injected with 4 x 10(7) cells subcutaneously or intramuscularly developed tumors at or near inoculation sites. Immunofluorescent antibody (IFA) staining for HTLV-I structural protein, p19, revealed the specific antigen in the cytoplasm of most cells from tumors and the DNA signals of HTLV-I proviral DNA were also positive in cellular DNA by polymerase chain reaction assay with HTLV-I tax gene primers, SK43/SK44. The MT-2 cells did not invade in mouse organs.

  20. Metallothionein MT2A A-5G Polymorphism as a Risk Factor for Chronic Kidney Disease and Diabetes: Cross-Sectional and Cohort Studies

    PubMed Central

    Hattori, Yuta; Naito, Mariko; Satoh, Masahiko; Nakatochi, Masahiro; Naito, Hisao; Kato, Masashi; Takagi, Sahoko; Matsunaga, Takashi; Seiki, Toshio; Sasakabe, Tae; Suma, Shino; Kawai, Sayo; Okada, Rieko; Hishida, Asahi; Hamajima, Nobuyuki; Wakai, Kenji

    2016-01-01

    Metallothioneins (MTs) are proteins that protect cells from toxic agents such as heavy metal ions or reactive oxygen species. MT2A A-5G is a single nucleotide polymorphism in the promoter region of the MT2A gene, and the minor G allele results in lower transcription efficiency. We aimed to elucidate associations between MT2A A-5G and risks of 2 diseases potentially related to lowered MT expression, chronic kidney disease (CKD), and diabetes mellitus (DM), in a community-dwelling population. Study subjects were Nagoya city residents participating in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC) Daiko Study, comprised 749 men and 2,025 women, aged 39–75 years. CKD (>stage 3) and DM were defined by standard guidelines. Associations were evaluated using logistic regression models with adjustments for age, sex and potential confounders in a cross-sectional study, and verified in a 5-year longitudinal study. Odds ratios (OR [95% confidence interval]) were calculated relative to the AA genotype. Serum MT (I + II), Cd and zinc levels were also determined by genotype. The OR of the GG genotype for CKD risk was 3.98 (1.50, 10.58) in the cross-sectional study and 5.17 (1.39, 19.28) in the longitudinal study. The OR of the GA genotype for DM was 1.86 (1.26, 2.75) in the cross-sectional study and 2.03 (1.19, 3.46) in the longitudinal study. MT2A A-5G may be associated with CKD and DM risks. This polymorphism is a promising target for evaluations of CKD and DM risks with possible involvement of low-dose chronic exposure to environmental pollutants. PMID:27122239

  1. Intracoronary melatonin increases coronary blood flow and cardiac function through β-adrenoreceptors, MT1/MT2 receptors, and nitric oxide in anesthetized pigs.

    PubMed

    Grossini, Elena; Molinari, Claudio; Uberti, Francesca; Mary, David A S G; Vacca, Giovanni; Caimmi, Philippe P

    2011-09-01

    Melatonin is involved in the regulation of the cardiovascular system through the modulation of sympathetic function and the nitric oxide (NO)-related pathway and interaction with MT1/MT2 receptors. However, information regarding its direct actions on coronary blood flow and cardiac function is scarce. This study therefore determined the primary in vivo effect of melatonin on cardiac function and perfusion and the involvement of the autonomic nervous system, MT1/MT2 receptors, and NO. In 35 pigs, melatonin infused into the coronary artery at 70 pg for each mL/min of coronary blood flow while preventing changes in heart rate and arterial pressure increased coronary blood flow, dP/dt(max), segmental shortening, and cardiac output by about 12%, 14%, 8%, and 23% of control values (P < 0.05), respectively. These effects were accompanied by an increase in coronary NO release of about 46% (P < 0.05) of control values. The aforementioned responses were graded in a further five pigs. Moreover, the blockade of muscarinic cholinoreceptors (n = 5) and α-adrenoreceptors (n = 5) did not abolish the observed responses to melatonin. After β(1)-adrenoreceptors blocking (n = 5), melatonin failed to affect cardiac function, whereas β(2)-adrenoreceptors (n = 5) and NO synthase inhibition (n = 5) prevented the coronary response and the effect of melatonin on NO release. Finally, all effects were prevented by MT1/MT2 receptor inhibitors (n = 10). In conclusion, melatonin primarily increased coronary blood flow and cardiac function through the involvement of MT1/MT2 receptors, β-adrenoreceptors, and NO release. These findings add new information about the mechanisms through which melatonin physiologically modulates cardiovascular function and exerts cardioprotective effects. © 2011 John Wiley & Sons A/S.

  2. Metallothionein MT2A A-5G Polymorphism as a Risk Factor for Chronic Kidney Disease and Diabetes: Cross-Sectional and Cohort Studies.

    PubMed

    Hattori, Yuta; Naito, Mariko; Satoh, Masahiko; Nakatochi, Masahiro; Naito, Hisao; Kato, Masashi; Takagi, Sahoko; Matsunaga, Takashi; Seiki, Toshio; Sasakabe, Tae; Suma, Shino; Kawai, Sayo; Okada, Rieko; Hishida, Asahi; Hamajima, Nobuyuki; Wakai, Kenji

    2016-07-01

    Metallothioneins (MTs) are proteins that protect cells from toxic agents such as heavy metal ions or reactive oxygen species. MT2A A-5G is a single nucleotide polymorphism in the promoter region of the MT2A gene, and the minor G allele results in lower transcription efficiency. We aimed to elucidate associations between MT2A A-5G and risks of 2 diseases potentially related to lowered MT expression, chronic kidney disease (CKD), and diabetes mellitus (DM), in a community-dwelling population. Study subjects were Nagoya city residents participating in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC) Daiko Study, comprised 749 men and 2,025 women, aged 39-75 years. CKD (>stage 3) and DM were defined by standard guidelines. Associations were evaluated using logistic regression models with adjustments for age, sex and potential confounders in a cross-sectional study, and verified in a 5-year longitudinal study. Odds ratios (OR [95% confidence interval]) were calculated relative to the AA genotype. Serum MT (I + II), Cd and zinc levels were also determined by genotype. The OR of the GG genotype for CKD risk was 3.98 (1.50, 10.58) in the cross-sectional study and 5.17 (1.39, 19.28) in the longitudinal study. The OR of the GA genotype for DM was 1.86 (1.26, 2.75) in the cross-sectional study and 2.03 (1.19, 3.46) in the longitudinal study. MT2A A-5G may be associated with CKD and DM risks. This polymorphism is a promising target for evaluations of CKD and DM risks with possible involvement of low-dose chronic exposure to environmental pollutants. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology.

  3. Higgs Boson Search at LHC (and LHC/CMS status)

    SciTech Connect

    Korytov, Andrey

    2008-11-23

    Presented are the results of the most recent studies by the CMS and ATLAS collaborations on the expected sensitivity of their detectors to observing a Higgs boson at LHC. The overview is preceded with a brief summary of the LHC and the CMS Experiment status.

  4. LNV Higgses at LHC

    NASA Astrophysics Data System (ADS)

    Maiezza, Alessio; Nemevšek, Miha; Nesti, Fabrizio

    2016-06-01

    Lepton number is a fundamental symmetry that can be probed at the LHC. Here, we study the Higgs sector of theories responsible for neutrino mass generation. After a brief discussion of simple see-saw scenarios, we turn to theories where heavy Majorana neutrino mass is protected by a gauge symmetry and focus on the Left-Right symmetric theory. There, the SM-like Higgs boson can decay to a pair of heavy neutrinos and provide enough information to establish the origin of neutrino mass.

  5. Theory - LHC Phenomenology

    NASA Astrophysics Data System (ADS)

    Gori, Stefania

    2017-01-01

    The discovery of the Higgs boson at the Large Hadron Collider marks the culmination of a decades-long hunt for the last ingredient of the Standard Model. At the same time, there are still many puzzles in particle physics, foremost the existence of a relatively light Higgs boson, seemingly without any extra weak scale particles that would stabilize the Higgs mass against quantum corrections, and the existence of Dark Matter. This talk will give an overview of the most interesting theories that address these problems and how to test these theories at the LHC.

  6. Monotops at the LHC

    SciTech Connect

    Andrea, J.; Fuks, B.

    2011-10-01

    We explore scenarios where top quarks may be produced singly in association with missing energy, a very distinctive signature, which, in analogy with monojets, we dub monotops. We find that monotops can be produced in a variety of modes, typically characterized by baryon number-violating or flavorchanging neutral interactions. We build a simplified model that encompasses all the possible (tree-level) production mechanisms and study the LHC sensitiveness to a few representative scenarios by considering fully hadronic top decays. We find that constraints on such exotic models can already be set with 1 fb{sup -1} of integrated luminosity collected at {radical}(s)=7 TeV.

  7. LNV Higgses at LHC

    SciTech Connect

    Maiezza, Alessio; Nemevšek, Miha; Nesti, Fabrizio

    2016-06-21

    Lepton number is a fundamental symmetry that can be probed at the LHC. Here, we study the Higgs sector of theories responsible for neutrino mass generation. After a brief discussion of simple see-saw scenarios, we turn to theories where heavy Majorana neutrino mass is protected by a gauge symmetry and focus on the Left-Right symmetric theory. There, the SM-like Higgs boson can decay to a pair of heavy neutrinos and provide enough information to establish the origin of neutrino mass.

  8. LHC - a "Why" Facility

    ScienceCinema

    Gordon Kane

    2016-07-12

    The Standard Models of particle physics and cosmology describe the world we see, and how it works, very well. But we want to understand (not just accommodate) much more – how does the Higgs mechanism work, what is the dark matter, why is the universe matter and not antimatter, why is parity violated, why are the particles (quarks and leptons) what they are, and why are the forces that act on them to make our world what they are, and more. Today is an exciting time to be doing particle physics – on the experimental side we have data coming from LHC and dark matter experiments that will provide clues to these questions, and on the theoretical side we have a framework (string theory) that addresses all these “why” questions. LHC data will not qualitatively improve our description – rather, it may provide the data that will allow us to learn about the dark matter, the Higgs physics, the matter asymmetry, etc, to test underlying theories such as string theory, and begin to answer the “why” questions. Supersymmetry is the best motivated discovery, and it would also open a window to the underlying theory near the Planck scale.

  9. Supersymmetry at LHC

    SciTech Connect

    Bartl, A.; Soederqvist, J.; Paige, F.

    1996-11-22

    Supersymmetry (SUSY) is an appealing concept which provides a plausible solution to the fine tuning problem, while leaving the phenomenological success of the Standard Model (SM) unchanged. Moreover, some SUSY models allow for the unification of gauge couplings at a scale of M{sub GUT} {approx} 10{sup 16} GeV. A further attractive feature is the possibility of radiative breaking of the electro-weak symmetry group SU(2) {times} U(1). The masses of the SUSY partners of the SM particles are expected to be in the range 100 GeV to 1 TeV. One of the main goals of the Large Hadron Collider (LHC) will be either to discover weak-scale SUSY or to exclude it over the entire theoretically allowed parameter space. The authors have developed a strategy for the analysis of experimental data at LHC which will allow them to determine the scale for supersymmetry, to limit the model parameter space, and to make precision measurements of model parameters.

  10. The ALICE experiment at the CERN LHC

    NASA Astrophysics Data System (ADS)

    ALICE Collaboration; Aamodt, K.; Abrahantes Quintana, A.; Achenbach, R.; Acounis, S.; Adamová, D.; Adler, C.; Aggarwal, M.; Agnese, F.; Aglieri Rinella, G.; Ahammed, Z.; Ahmad, A.; Ahmad, N.; Ahmad, S.; Akindinov, A.; Akishin, P.; Aleksandrov, D.; Alessandro, B.; Alfaro, R.; Alfarone, G.; Alici, A.; Alme, J.; Alt, T.; Altinpinar, S.; Amend, W.; Andrei, C.; Andres, Y.; Andronic, A.; Anelli, G.; Anfreville, M.; Angelov, V.; Anzo, A.; Anson, C.; Anticić, T.; Antonenko, V.; Antonczyk, D.; Antinori, F.; Antinori, S.; Antonioli, P.; Aphecetche, L.; Appelshäuser, H.; Aprodu, V.; Arba, M.; Arcelli, S.; Argentieri, A.; Armesto, N.; Arnaldi, R.; Arefiev, A.; Arsene, I.; Asryan, A.; Augustinus, A.; Awes, T. C.; Äysto, J.; Danish Azmi, M.; Bablock, S.; Badalà, A.; Badyal, S. K.; Baechler, J.; Bagnasco, S.; Bailhache, R.; Bala, R.; Baldisseri, A.; Baldit, A.; Bán, J.; Barbera, R.; Barberis, P.-L.; Barbet, J. M.; Barnäfoldi, G.; Barret, V.; Bartke, J.; Bartos, D.; Basile, M.; Basmanov, V.; Bastid, N.; Batigne, G.; Batyunya, B.; Baudot, J.; Baumann, C.; Bearden, I.; Becker, B.; Belikov, J.; Bellwied, R.; Belmont-Moreno, E.; Belogianni, A.; Belyaev, S.; Benato, A.; Beney, J. L.; Benhabib, L.; Benotto, F.; Beolé, S.; Berceanu, I.; Bercuci, A.; Berdermann, E.; Berdnikov, Y.; Bernard, C.; Berny, R.; Berst, J. D.; Bertelsen, H.; Betev, L.; Bhasin, A.; Baskar, P.; Bhati, A.; Bianchi, N.; Bielčik, J.; Bielčiková, J.; Bimbot, L.; Blanchard, G.; Blanco, F.; Blanco, F.; Blau, D.; Blume, C.; Blyth, S.; Boccioli, M.; Bogdanov, A.; Bøggild, H.; Bogolyubsky, M.; Boldizsár, L.; Bombara, M.; Bombonati, C.; Bondila, M.; Bonnet, D.; Bonvicini, V.; Borel, H.; Borotto, F.; Borshchov, V.; Bortoli, Y.; Borysov, O.; Bose, S.; Bosisio, L.; Botje, M.; Böttger, S.; Bourdaud, G.; Bourrion, O.; Bouvier, S.; Braem, A.; Braun, M.; Braun-Munzinger, P.; Bravina, L.; Bregant, M.; Bruckner, G.; Brun, R.; Bruna, E.; Brunasso, O.; Bruno, G. E.; Bucher, D.; Budilov, V.; Budnikov, D.; Buesching, H.; Buncic, P.; Burns, M.; Burachas, S.; Busch, O.; Bushop, J.; Cai, X.; Caines, H.; Calaon, F.; Caldogno, M.; Cali, I.; Camerini, P.; Campagnolo, R.; Campbell, M.; Cao, X.; Capitani, G. P.; Romeo, G. Cara; Cardenas-Montes, M.; Carduner, H.; Carena, F.; Carena, W.; Cariola, P.; Carminati, F.; Casado, J.; Casanova Diaz, A.; Caselle, M.; Castillo Castellanos, J.; Castor, J.; Catanescu, V.; Cattaruzza, E.; Cavazza, D.; Cerello, P.; Ceresa, S.; Černý, V.; Chambert, V.; Chapeland, S.; Charpy, A.; Charrier, D.; Chartoire, M.; Charvet, J. L.; Chattopadhyay, S.; Chattopadhyay, S.; Chepurnov, V.; Chernenko, S.; Cherney, M.; Cheshkov, C.; Cheynis, B.; Chochula, P.; Chiavassa, E.; Chibante Barroso, V.; Choi, J.; Christakoglou, P.; Christiansen, P.; Christensen, C.; Chykalov, O. A.; Cicalo, C.; Cifarelli-Strolin, L.; Ciobanu, M.; Cindolo, F.; Cirstoiu, C.; Clausse, O.; Cleymans, J.; Cobanoglu, O.; Coffin, J.-P.; Coli, S.; Colla, A.; Colledani, C.; Combaret, C.; Combet, M.; Comets, M.; Conesa Balbastre, G.; Conesa del Valle, Z.; Contin, G.; Contreras, J.; Cormier, T.; Corsi, F.; Cortese, P.; Costa, F.; Crescio, E.; Crochet, P.; Cuautle, E.; Cussonneau, J.; Dahlinger, M.; Dainese, A.; Dalsgaard, H. H.; Daniel, L.; Das, I.; Das, T.; Dash, A.; Da Silva, R.; Davenport, M.; Daues, H.; DeCaro, A.; de Cataldo, G.; DeCuveland, J.; DeFalco, A.; de Gaspari, M.; de Girolamo, P.; de Groot, J.; DeGruttola, D.; DeHaas, A.; DeMarco, N.; DePasquale, S.; DeRemigis, P.; de Vaux, D.; Decock, G.; Delagrange, H.; DelFranco, M.; Dellacasa, G.; Dell'Olio, C.; Dell'Olio, D.; Deloff, A.; Demanov, V.; Dénes, E.; D'Erasmo, G.; Derkach, D.; Devaux, A.; Di Bari, D.; Di Bartelomen, A.; Di Giglio, C.; Di Liberto, S.; Di Mauro, A.; Di Nezza, P.; Dialinas, M.; Diaz, L.; Díaz Valdes, R.; Dietel, T.; Dima, R.; Ding, H.; Dinca, C.; Divià, R.; Dobretsov, V.; Dobrin, A.; Doenigus, B.; Dobrowolski, T.; Domínguez, I.; Dorn, M.; Drouet, S.; Dubey, A. E.; Ducroux, L.; Dumitrache, F.; Dumonteil, E.; Dupieux, P.; Duta, V.; Dutta Majumdar, A.; Dutta Majumdar, M.; Dyhre, Th; Efimov, L.; Efremov, A.; Elia, D.; Emschermann, D.; Engster, C.; Enokizono, A.; Espagnon, B.; Estienne, M.; Evangelista, A.; Evans, D.; Evrard, S.; Fabjan, C. W.; Fabris, D.; Faivre, J.; Falchieri, D.; Fantoni, A.; Farano, R.; Fearick, R.; Fedorov, O.; Fekete, V.; Felea, D.; Feofilov, G.; Férnandez Téllez, A.; Ferretti, A.; Fichera, F.; Filchagin, S.; Filoni, E.; Finck, C.; Fini, R.; Fiore, E. M.; Flierl, D.; Floris, M.; Fodor, Z.; Foka, Y.; Fokin, S.; Force, P.; Formenti, F.; Fragiacomo, E.; Fragkiadakis, M.; Fraissard, D.; Franco, A.; Franco, M.; Frankenfeld, U.; Fratino, U.; Fresneau, S.; Frolov, A.; Fuchs, U.; Fujita, J.; Furget, C.; Furini, M.; Fusco Girard, M.; Gaardhøje, J.-J.; Gabrielli, A.; Gadrat, S.; Gagliardi, M.; Gago, A.; Gaido, L.; Gallas Torreira, A.; Gallio, M.; Gandolfi, E.; Ganoti, P.; Ganti, M.; Garabatos, J.; Garcia Lopez, A.; Garizzo, L.; Gaudichet, L.; Gemme, R.; Germain, M.; Gheata, A.; Gheata, M.; Ghidini, B.; Ghosh, P.; Giolu, G.; Giraudo, G.; Giubellino, P.; Glasow, R.; Glässel, P.; Ferreiro, E. G.; Gonzalez Gutierrez, C.; Gonzales-Trueba, L. H.; Gorbunov, S.; Gorbunov, Y.; Gos, H.; Gosset, J.; Gotovac, S.; Gottschlag, H.; Gottschalk, D.; Grabski, V.; Grassi, T.; Gray, H.; Grebenyuk, O.; Grebieszkow, K.; Gregory, C.; Grigoras, C.; Grion, N.; Grigoriev, V.; Grigoryan, A.; Grigoryan, C.; Grigoryan, S.; Grishuk, Y.; Gros, P.; Grosse-Oetringhaus, J.; Grossiord, J.-Y.; Grosso, R.; Grynyov, B.; Guarnaccia, C.; Guber, F.; Guerin, F.; Guernane, R.; Guerzoni, M.; Guichard, A.; Guida, M.; Guilloux, G.; Gulkanyan, H.; Gulbrandsen, K.; Gunji, T.; Gupta, A.; Gupta, V.; Gustafsson, H.-A.; Gutbrod, H.; Hadjidakis, C.; Haiduc, M.; Hamar, G.; Hamagaki, H.; Hamblen, J.; Hansen, J. C.; Hardy, P.; Hatzifotiadou, D.; Harris, J. W.; Hartig, M.; Harutyunyan, A.; Hayrapetyan, A.; Hasch, D.; Hasegan, D.; Hehner, J.; Heine, N.; Heinz, M.; Helstrup, H.; Herghelegiu, A.; Herlant, S.; Herrera Corral, G.; Herrmann, N.; Hetland, K.; Hille, P.; Hinke, H.; Hippolyte, B.; Hoch, M.; Hoebbel, H.; Hoedlmoser, H.; Horaguchi, T.; Horner, M.; Hristov, P.; Hřivnáčová, I.; Hu, S.; Guo, C. Hu; Humanic, T.; Hurtado, A.; Hwang, D. S.; Ianigro, J. C.; Idzik, M.; Igolkin, S.; Ilkaev, R.; Ilkiv, I.; Imhoff, M.; Innocenti, P. G.; Ionescu, E.; Ippolitov, M.; Irfan, M.; Insa, C.; Inuzuka, M.; Ivan, C.; Ivanov, A.; Ivanov, M.; Ivanov, V.; Jacobs, P.; Jacholkowski, A.; Jančurová, L.; Janik, R.; Jasper, M.; Jena, C.; Jirden, L.; Johnson, D. P.; Jones, G. T.; Jorgensen, C.; Jouve, F.; Jovanović, P.; Junique, A.; Jusko, A.; Jung, H.; Jung, W.; Kadija, K.; Kamal, A.; Kamermans, R.; Kapusta, S.; Kaidalov, A.; Kakoyan, V.; Kalcher, S.; Kang, E.; Kapitan, J.; Kaplin, V.; Karadzhev, K.; Karavichev, O.; Karavicheva, T.; Karpechev, E.; Karpio, K.; Kazantsev, A.; Kebschull, U.; Keidel, R.; Mohsin Khan, M.; Khanzadeev, A.; Kharlov, Y.; Kikola, D.; Kileng, B.; Kim, D.; Kim, D. S.; Kim, D. W.; Kim, H. N.; Kim, J. S.; Kim, S.; Kinson, J. B.; Kiprich, S. K.; Kisel, I.; Kiselev, S.; Kisiel, A.; Kiss, T.; Kiworra, V.; Klay, J.; Klein Bösing, C.; Kliemant, M.; Klimov, A.; Klovning, A.; Kluge, A.; Kluit, R.; Kniege, S.; Kolevatov, R.; Kollegger, T.; Kolojvari, A.; Kondratiev, V.; Kornas, E.; Koshurnikov, E.; Kotov, I.; Kour, R.; Kowalski, M.; Kox, S.; Kozlov, K.; Králik, I.; Kramer, F.; Kraus, I.; Kravčáková, A.; Krawutschke, T.; Krivda, M.; Kryshen, E.; Kucheriaev, Y.; Kugler, A.; Kuhn, C.; Kuijer, P.; Kumar, L.; Kumar, N.; Kumpumaeki, P.; Kurepin, A.; Kurepin, A. N.; Kushpil, S.; Kushpil, V.; Kutovsky, M.; Kvaerno, H.; Kweon, M.; Labbé, J.-C.; Lackner, F.; Ladron de Guevara, P.; Lafage, V.; La Rocca, P.; Lamont, M.; Lara, C.; Larsen, D. T.; Laurenti, G.; Lazzeroni, C.; LeBornec, Y.; LeBris, N.; LeGailliard, C.; Lebedev, V.; Lecoq, J.; Lee, K. S.; Lee, S. C.; Lefévre, F.; Legrand, I.; Lehmann, T.; Leistam, L.; Lenoir, P.; Lenti, V.; Leon, H.; Monzon, I. Leon; Lévai, P.; Li, Q.; Li, X.; Librizzi, F.; Lietava, R.; Lindegaard, N.; Lindenstruth, V.; Lippmann, C.; Lisa, M.; Listratenko, O. M.; Littel, F.; Liu, Y.; Lo, J.; Lobanov, V.; Loginov, V.; López Noriega, M.; López-Ramírez, R.; López Torres, E.; Lorenzo, P. M.; Løvhøiden, G.; Lu, S.; Ludolphs, W.; Lunardon, M.; Luquin, L.; Lusso, S.; Lutz, J.-R.; Luvisetto, M.; Lyapin, V.; Maevskaya, A.; Magureanu, C.; Mahajan, A.; Majahan, S.; Mahmoud, T.; Mairani, A.; Mahapatra, D.; Makarov, A.; Makhlyueva, I.; Malek, M.; Malkiewicz, T.; Mal'Kevich, D.; Malzacher, P.; Mamonov, A.; Manea, C.; Mangotra, L. K.; Maniero, D.; Manko, V.; Manso, F.; Manzari, V.; Mao, Y.; Marcel, A.; Marchini, S.; Mareš, J.; Margagliotti, G. V.; Margotti, A.; Marin, A.; Marin, J.-C.; Marras, D.; Martinengo, P.; Martínez, M. I.; Martinez-Davalos, A.; Martínez Garcia, G.; Martini, S.; Marzari Chiesa, A.; Marzocca, C.; Masciocchi, S.; Masera, M.; Masetti, M.; Maslov, N. I.; Masoni, A.; Massera, F.; Mast, M.; Mastroserio, A.; Matthews, Z. L.; Mayer, B.; Mazza, G.; Mazzaro, M. D.; Mazzoni, A.; Meddi, F.; Meleshko, E.; Menchaca-Rocha, A.; Meneghini, S.; Meoni, M.; Mercado Perez, J.; Mereu, P.; Meunier, O.; Miake, Y.; Michalon, A.; Michinelli, R.; Miftakhov, N.; Mignone, M.; Mikhailov, K.; Milosevic, J.; Minaev, Y.; Minafra, F.; Mischke, A.; Miśkowiec, D.; Mitsyn, V.; Mitu, C.; Mohanty, B.; Moisa, D.; Molnar, L.; Mondal, M.; Mondal, N.; Montaño Zetina, L.; Monteno, M.; Morando, M.; Morel, M.; Moretto, S.; Morhardt, Th; Morsch, A.; Moukhanova, T.; Mucchi, M.; Muccifora, V.; Mudnic, E.; Müller, H.; Müller, W.; Munoz, J.; Mura, D.; Musa, L.; Muraz, J. F.; Musso, A.; Nania, R.; Nandi, B.; Nappi, E.; Navach, F.; Navin, S.; Nayak, T.; Nazarenko, S.; Nazarov, G.; Nellen, L.; Nendaz, F.; Nianine, A.; Nicassio, M.; Nielsen, B. S.; Nikolaev, S.; Nikolic, V.; Nikulin, S.; Nikulin, V.; Nilsen, B.; Nitti, M.; Noferini, F.; Nomokonov, P.; Nooren, G.; Noto, F.; Nouais, D.; Nyiri, A.; Nystrand, J.; Odyniec, G.; Oeschler, H.; Oinonen, M.; Oldenburg, M.; Oleks, I.; Olsen, E. K.; Onuchin, V.; Oppedisano, C.; Orsini, F.; Ortiz-Velázquez, A.; Oskamp, C.; Oskarsson, A.; Osmic, F.; Österman, L.; Otterlund, I.; Ovrebekk, G.; Oyama, K.; Pachr, M.; Pagano, P.; Paić, G.; Pajares, C.; Pal, S.; Pal, S.; Pálla, G.; Palmeri, A.; Pancaldi, G.; Panse, R.; Pantaleo, A.; Pappalardo, G. S.; Pastirčák, B.; Pastore, C.; Patarakin, O.; Paticchio, V.; Patimo, G.; Pavlinov, A.; Pawlak, T.; Peitzmann, T.; Pénichot, Y.; Pepato, A.; Pereira, H.; Peresunko, D.; Perez, C.; Perez Griffo, J.; Perini, D.; Perrino, D.; Peryt, W.; Pesci, A.; Peskov, V.; Pestov, Y.; Peters, A. J.; Petráček, V.; Petridis, A.; Petris, M.; Petrov, V.; Petrov, V.; Petrovici, M.; Peyré, J.; Piano, S.; Piccotti, A.; Pichot, P.; Piemonte, C.; Pikna, M.; Pilastrini, R.; Pillot, P.; Pinazza, O.; Pini, B.; Pinsky, L.; Pinto Morais, V.; Pismennaya, V.; Piuz, F.; Platt, R.; Ploskon, M.; Plumeri, S.; Pluta, J.; Pocheptsov, T.; Podesta, P.; Poggio, F.; Poghosyan, M.; Poghosyan, T.; Polák, K.; Polichtchouk, B.; Polozov, P.; Polyakov, V.; Pommeresch, B.; Pompei, F.; Pop, A.; Popescu, S.; Posa, F.; Pospíšil, V.; Potukuchi, B.; Pouthas, J.; Prasad, S.; Preghenella, R.; Prino, F.; Prodan, L.; Prono, G.; Protsenko, M. A.; Pruneau, C. A.; Przybyla, A.; Pshenichnov, I.; Puddu, G.; Pujahari, P.; Pulvirenti, A.; Punin, A.; Punin, V.; Putschke, J.; Quartieri, J.; Quercigh, E.; Rachevskaya, I.; Rachevski, A.; Rademakers, A.; Radomski, S.; Radu, A.; Rak, J.; Ramello, L.; Raniwala, R.; Raniwala, S.; Rasmussen, O. B.; Rasson, J.; Razin, V.; Read, K.; Real, J.; Redlich, K.; Reichling, C.; Renard, C.; Renault, G.; Renfordt, R.; Reolon, A. R.; Reshetin, A.; Revol, J.-P.; Reygers, K.; Ricaud, H.; Riccati, L.; Ricci, R. A.; Richter, M.; Riedler, P.; Rigalleau, L. M.; Riggi, F.; Riegler, W.; Rindel, E.; Riso, J.; Rivetti, A.; Rizzi, M.; Rizzi, V.; Rodriguez Cahuantzi, M.; Røed, K.; Röhrich, D.; Román-López, S.; Romanato, M.; Romita, R.; Ronchetti, F.; Rosinsky, P.; Rosnet, P.; Rossegger, S.; Rossi, A.; Rostchin, V.; Rotondo, F.; Roukoutakis, F.; Rousseau, S.; Roy, C.; Roy, D.; Roy, P.; Royer, L.; Rubin, G.; Rubio, A.; Rui, R.; Rusanov, I.; Russo, G.; Ruuskanen, V.; Ryabinkin, E.; Rybicki, A.; Sadovsky, S.; Šafařík, K.; Sahoo, R.; Saini, J.; Saiz, P.; Salur, S.; Sambyal, S.; Samsonov, V.; Šándor, L.; Sandoval, A.; Sann, H.; Santiard, J.-C.; Santo, R.; Santoro, R.; Sargsyan, G.; Saturnini, P.; Scapparone, E.; Scarlassara, F.; Schackert, B.; Schiaua, C.; Schicker, R.; Schioler, T.; Schippers, J. D.; Schmidt, C.; Schmidt, H.; Schneider, R.; Schossmaier, K.; Schukraft, J.; Schutz, Y.; Schwarz, K.; Schweda, K.; Schyns, E.; Scioli, G.; Scomparin, E.; Snow, H.; Sedykh, S.; Segato, G.; Sellitto, S.; Semeria, F.; Senyukov, S.; Seppänen, H.; Serci, S.; Serkin, L.; Serra, S.; Sesselmann, T.; Sevcenco, A.; Sgura, I.; Shabratova, G.; Shahoyan, R.; Sharkov, E.; Sharma, S.; Shigaki, K.; Shileev, K.; Shukla, P.; Shurygin, A.; Shurygina, M.; Sibiriak, Y.; Siddi, E.; Siemiarczuk, T.; Sigward, M. H.; Silenzi, A.; Silvermyr, D.; Silvestri, R.; Simili, E.; Simion, V.; Simon, R.; Simonetti, L.; Singaraju, R.; Singhal, V.; Sinha, B.; Sinha, T.; Siska, M.; Sitár, B.; Sitta, M.; Skaali, B.; Skowronski, P.; Slodkowski, M.; Smirnov, N.; Smykov, L.; Snellings, R.; Snoeys, W.; Soegaard, C.; Soerensen, J.; Sokolov, O.; Soldatov, A.; Soloviev, A.; Soltveit, H.; Soltz, R.; Sommer, W.; Soos, C.; Soramel, F.; Sorensen, S.; Soyk, D.; Spyropoulou-Stassinaki, M.; Stachel, J.; Staley, F.; Stan, I.; Stavinskiy, A.; Steckert, J.; Stefanini, G.; Stefanek, G.; Steinbeck, T.; Stelzer, H.; Stenlund, E.; Stocco, D.; Stockmeier, M.; Stoicea, G.; Stolpovsky, P.; Strmeň, P.; Stutzmann, J. S.; Su, G.; Sugitate, T.; Šumbera, M.; Suire, C.; Susa, T.; Sushil Kumar, K.; Swoboda, D.; Symons, J.; Szarka, I.; Szostak, A.; Szuba, M.; Szymanski, P.; Tadel, M.; Tagridis, C.; Tan, L.; Tapia Takaki, D.; Taureg, H.; Tauro, A.; Tavlet, M.; Tejeda Munoz, G.; Thäder, J.; Tieulent, R.; Timmer, P.; Tolyhy, T.; Topilskaya, N.; Torcato de Matos, C.; Torii, H.; Toscano, L.; Tosello, F.; Tournaire, A.; Traczyk, T.; Tröger, G.; Tromeur, W.; Truesdale, D.; Trzaska, W.; Tsiledakis, G.; Tsilis, E.; Tsvetkov, A.; Turcato, M.; Turrisi, R.; Tuveri, M.; Tveter, T.; Tydesjo, H.; Tykarski, L.; Tywoniuk, K.; Ugolini, E.; Ullaland, K.; Urbán, J.; Urciuoli, G. M.; Usai, G. L.; Usseglio, M.; Vacchi, A.; Vala, M.; Valiev, F.; Vande Vyvre, P.; Van Den Brink, A.; Van Eijndhoven, N.; Van Der Kolk, N.; van Leeuwen, M.; Vannucci, L.; Vanzetto, S.; Vanuxem, J.-P.; Vargas, M. A.; Varma, R.; Vascotto, A.; Vasiliev, A.; Vassiliou, M.; Vasta, P.; Vechernin, V.; Venaruzzo, M.; Vercellin, E.; Vergara, S.; Verhoeven, W.; Veronese, F.; Vetlitskiy, I.; Vernet, R.; Victorov, V.; Vidak, L.; Viesti, G.; Vikhlyantsev, O.; Vilakazi, Z.; Villalobos Baillie, O.; Vinogradov, A.; Vinogradov, L.; Vinogradov, Y.; Virgili, T.; Viyogi, Y.; Vodopianov, A.; Volpe, G.; Vranic, D.; Vrláková, J.; Vulpescu, B.; Wabnitz, C.; Wagner, V.; Wallet, L.; Wan, R.; Wang, Y.; Wang, Y.; Wheadon, R.; Weis, R.; Wen, Q.; Wessels, J.; Westergaard, J.; Wiechula, J.; Wiesenaecker, A.; Wikne, J.; Wilk, A.; Wilk, G.; Williams, C.; Willis, N.; Windelband, B.; Witt, R.; Woehri, H.; Wyllie, K.; Xu, C.; Yang, C.; Yang, H.; Yermia, F.; Yin, Z.; Yin, Z.; Ky, B. Yun; Yushmanov, I.; Yuting, B.; Zabrodin, E.; Zagato, S.; Zagreev, B.; Zaharia, P.; Zalite, A.; Zampa, G.; Zampolli, C.; Zanevskiy, Y.; Zarochentsev, A.; Zaudtke, O.; Závada, P.; Zbroszczyk, H.; Zepeda, A.; Zeter, V.; Zgura, I.; Zhalov, M.; Zhou, D.; Zhou, S.; Zhu, G.; Zichichi, A.; Zinchenko, A.; Zinovjev, G.; Zoccarato, Y.; Zubarev, A.; Zucchini, A.; Zuffa, M.

    2008-08-01

    ALICE (A Large Ion Collider Experiment) is a general-purpose, heavy-ion detector at the CERN LHC which focuses on QCD, the strong-interaction sector of the Standard Model. It is designed to address the physics of strongly interacting matter and the quark-gluon plasma at extreme values of energy density and temperature in nucleus-nucleus collisions. Besides running with Pb ions, the physics programme includes collisions with lighter ions, lower energy running and dedicated proton-nucleus runs. ALICE will also take data with proton beams at the top LHC energy to collect reference data for the heavy-ion programme and to address several QCD topics for which ALICE is complementary to the other LHC detectors. The ALICE detector has been built by a collaboration including currently over 1000 physicists and engineers from 105 Institutes in 30 countries. Its overall dimensions are 16 × 16 × 26 m3 with a total weight of approximately 10 000 t. The experiment consists of 18 different detector systems each with its own specific technology choice and design constraints, driven both by the physics requirements and the experimental conditions expected at LHC. The most stringent design constraint is to cope with the extreme particle multiplicity anticipated in central Pb-Pb collisions. The different subsystems were optimized to provide high-momentum resolution as well as excellent Particle Identification (PID) over a broad range in momentum, up to the highest multiplicities predicted for LHC. This will allow for comprehensive studies of hadrons, electrons, muons, and photons produced in the collision of heavy nuclei. Most detector systems are scheduled to be installed and ready for data taking by mid-2008 when the LHC is scheduled to start operation, with the exception of parts of the Photon Spectrometer (PHOS), Transition Radiation Detector (TRD) and Electro Magnetic Calorimeter (EMCal). These detectors will be completed for the high-luminosity ion run expected in 2010. This

  11. SUSY at the ILC and Solving the LHC Inverse Problem

    SciTech Connect

    Gainer, James S.; /SLAC

    2008-05-28

    Recently a large scale study of points in the MSSM parameter space which are problematic at the Large Hadron Collider (LHC) has been performed. This work was carried out in part to determine whether the proposed International Linear Collider (ILC) could be used to solve the LHC inverse problem. The results suggest that while the ILC will be a valuable tool, an energy upgrade may be crucial to its success, and that, in general, precision studies of the MSSM are more difficult at the ILC than has generally been believed.

  12. PDF4LHC recommendations for LHC Run II

    DOE PAGES

    Butterworth, Jon; Carrazza, Stefano; Cooper-Sarkar, Amanda; ...

    2016-01-06

    We provide an updated recommendation for the usage of sets of parton distribution functions (PDFs) and the assessment of PDF and PDF+αs uncertainties suitable for applications at the LHC Run II. We review developments since the previous PDF4LHC recommendation, and discuss and compare the new generation of PDFs, which include substantial information from experimental data from the Run I of the LHC. We then propose a new prescription for the combination of a suitable subset of the available PDF sets, which is presented in terms of a single combined PDF set. Lastly, we finally discuss tools which allow for themore » delivery of this combined set in terms of optimized sets of Hessian eigenvectors or Monte Carlo replicas, and their usage, and provide some examples of their application to LHC phenomenology.« less

  13. PDF4LHC recommendations for LHC Run II

    SciTech Connect

    Butterworth, Jon; Carrazza, Stefano; Cooper-Sarkar, Amanda; Roeck, Albert De; Feltesse, Joel; Gao, Jun; Glazov, Sasha; Huston, Joey; Kassabov, Zahari; McNulty, Ronan; Morsch, Andreas; Nadolsky, Pavel; Radescu, Voica; Rojo, Juan; Thorne, Robert

    2016-01-06

    We provide an updated recommendation for the usage of sets of parton distribution functions (PDFs) and the assessment of PDF and PDF+αs uncertainties suitable for applications at the LHC Run II. We review developments since the previous PDF4LHC recommendation, and discuss and compare the new generation of PDFs, which include substantial information from experimental data from the Run I of the LHC. We then propose a new prescription for the combination of a suitable subset of the available PDF sets, which is presented in terms of a single combined PDF set. Lastly, we finally discuss tools which allow for the delivery of this combined set in terms of optimized sets of Hessian eigenvectors or Monte Carlo replicas, and their usage, and provide some examples of their application to LHC phenomenology.

  14. Catabolism of pseudocumene and 3-ethyltoluene by Pseudomonas putida (arvilla) mt-2: evidence for new functions of the TOL (pWWO) plasmid.

    PubMed Central

    Kunz, D A; Chapman, P J

    1981-01-01

    Pseudocumene (1,2,4-trimethylbenzene) and 3-ethyltoluene were found to serve as growth substrates for Pseudomonas putida (arvilla) mt-2, in addition to toluene, m-xylene, and p-xylene as previously described. Similar observations were made with several additional P. putida strains also capable of growth with toluene and the xylenes. Additional substrates which supported the growth of these organisms included 3,4-dimethylbenzyl alcohol, 3,4-dimethylbenzoate, and 3-ethylbenzoate. P. putida mt-2 cells grown either with toluene or pseudocumene rapidly oxidized toluene, pseudocumene, and 3-ethyltoluene as well as 3,4-dimethylbenzoate, 3-ethylbenzoate, 3,4-dimethylcatechol, and 3-ethylcatechol. Cell extracts from similarly grown P. putida mt-2 cells catalyzed a meta fission of 3,4-dimethylcatechol and 3-ethylcatechol to compounds having the spectral properties of 2-hydroxy-5-methyl-6-oxo-2,4-heptadienoate and 2-hydroxy-6-ox-2,4-octadienoate, respectively. The further metabolism of these intermediates was shown to be independent of oxidized nicotinamide adenine dinucleotide (NAD+) and resulted in the formation of essentially equimolar amounts of pyruvate, indicating that each ring fission product was degraded via the hydrolytic branch of the meta fission pathway. Treatment of cells with N-methyl-N'-nitro-N-nitrosoguanidine led to the isolation of a mutant, which when grown with succinate in the presence of pseudocumene or 3-ethyltoluene accumulated 3,4-dimethylcatechol or 3-ethylcatechol. Cells unable to utilize toluene, m-xylene, and p-xylene, obtained by growth in benzoate, also lost the ability to utilize pseudocumene and 3-ethyltoluene. The ability to utilize these substrates could be reacquired by incubation with a leucine auxotroph otherwise able to grow on all of the aromatic substrates. PMID:7216999

  15. Technicolor walks at the LHC

    SciTech Connect

    Belyaev, Alexander; Foadi, Roshan; Frandsen, Mads T.; Jaervinen, Matti; Sannino, Francesco; Pukhov, Alexander

    2009-02-01

    We analyze the potential of the Large Hadron Collider (LHC) to observe signatures of phenomenologically viable walking technicolor models. We study and compare the Drell-Yan and vector boson fusion mechanisms for the production of composite heavy vectors. We find that the heavy vectors are most easily produced and detected via the Drell-Yan processes. The composite Higgs phenomenology is also studied. If technicolor walks at the LHC, its footprints will be visible and our analysis will help in uncovering them.

  16. The High Luminosity LHC Project

    NASA Astrophysics Data System (ADS)

    Rossi, Lucio

    The High Luminosity LHC is one of the major scientific project of the next decade. It aims at increasing the luminosity reach of LHC by a factor five for peak luminosity and a factor ten in integrated luminosity. The project, now fully approved and funded, will be finished in ten years and will prolong the life of LHC until 2035-2040. It implies deep modifications of the LHC for about 1.2 km around the high luminosity insertions of ATLAS and CMS and relies on new cutting edge technologies. We are developing new advanced superconducting magnets capable of reaching 12 T field; superconducting RF crab cavities capable to rotate the beams with great accuracy; 100 kA and hundred meter long superconducting links for removing the power converter out of the tunnel; new collimator concepts, etc... Beside the important physics goals, the High Luminosity LHC project is an ideal test bed for new technologies for the next hadron collider for the post-LHC era.

  17. A second chromosomal copy of the catA gene endows Pseudomonas putida mt-2 with an enzymatic safety valve for excess of catechol.

    PubMed

    Jiménez, Jose I; Pérez-Pantoja, Danilo; Chavarría, Max; Díaz, Eduardo; de Lorenzo, Víctor

    2014-06-01

    Pseudomonas putida mt-2 harbours two different routes for catabolism of catechol, namely one meta pathway encoded by the xyl genes of the TOL plasmid pWW0 and one ortho pathway determined by the chromosomal ben and cat genes. P. putida mt-2 has a second chromosomal copy of the catA gene (named catA2) located downstream of the ben operon that encodes an additional catechol-1,2-dioxygenase. The metabolic and regulatory phenotypes of strains lacking one enzyme, the other and both of them in cells with and without the TOL plasmid were evaluated. The data consistently indicated that induction of the ortho pathway by benzoate plasmid-less strain P. putida KT2440 led to catechol surplus, the toxicity of which at high concentrations being counteracted by CatA2. Cells carrying pWW0 but lacking catA2 experienced both a rapid loss of the plasmid when grown on benzoate (a substrate of the lower pathway) and a slowdown of their growth rate when cultured with benzylalcohol (a substrate converted to benzoate by the upper pathway). These data reveal the role of CatA2 as a type of metabolic safety valve for excess catechol that alleviates the metabolic conflict generated by simultaneous expression of the meta and ortho pathways, thereby facilitating their co-existence.

  18. Synthesis and pharmacological evaluation of a series of the agomelatine analogues as melatonin MT1 /MT2 agonist and 5-HT2C antagonist.

    PubMed

    Ettaoussi, Mohamed; Sabaouni, Ahmed; Pérès, Basile; Landagaray, Elodie; Nosjean, Olivier; Boutin, Jean A; Caignard, Daniel-Henri; Delagrange, Philippe; Berthelot, Pascal; Yous, Saïd

    2013-11-01

    Agomelatine is a naphthalenic analogue of melatonin that is in clinical use for the treatment of major depressive disorders. Interestingly, while agomelatine exhibits potent affinity for melatonin receptors, it binds with only moderate affinity to the serotonin 5-HT2C receptor. Optimization of agomelatine toward this target could further potentiate its clinical efficacy. To explore this hypothesis and to access derivatives in which a key point of agomelatine metabolism is blocked, a series of naphthalenic derivatives was designed and synthesized as novel analogues of agomelatine. Most of the prepared compounds exhibited good binding affinity at the melatonin MT1 and MT2 receptor subtypes. Two compounds, an acetamide and an acrylamide derivative, exhibited good binding affinities at both the human melatonin (MT) receptors and the serotonin 5-HT2C receptor subtype, with pKi values of 7.96 and 7.95 against MT1, 7.86 and 8.68 against MT2, and 6.64 and 6.44 against 5-HT2C, respectively. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Four tops for LHC

    NASA Astrophysics Data System (ADS)

    Alvarez, Ezequiel; Faroughy, Darius A.; Kamenik, Jernej F.; Morales, Roberto; Szynkman, Alejandro

    2017-02-01

    We design a search strategy for the Standard Model t t bar t t bar production at the LHC in the same-sign dilepton and trilepton channels. We study different signal features and, given the small expected number of signal events, we scrutinize in detail all reducible and irreducible backgrounds. Our analysis shows that by imposing a basic set of jet and lepton selection criteria, the SM pp → t t bar t t bar process could be evidenced in the near future, within Run-II, when combining both multi-lepton search channels. We argue that this search strategy should also be used as a guideline to test New Physics coupling predominantly to top-quarks. In particular, we show that a non-resonant New Physics enhancement in the four-top final state would be detectable through this search strategy. We study two top-philic simplified models of this kind, a neutral scalar boson and a Z‧, and present current and future exclusion limits on their mass and couplings.

  20. Searching for radiative neutrino mass generation at the LHC

    NASA Astrophysics Data System (ADS)

    Volkas, Raymond R.

    2015-04-01

    In this talk (talk given at the International Conference on Massive Neutrinos, Singapore, 9-13 February 2015), I describe the general characteristics of radiative neutrino mass models that can be probed at the LHC. I then cover the specific constraints on a new, explicit model of this type.

  1. The Standard Model from LHC to future colliders.

    PubMed

    Forte, S; Nisati, A; Passarino, G; Tenchini, R; Calame, C M Carloni; Chiesa, M; Cobal, M; Corcella, G; Degrassi, G; Ferrera, G; Magnea, L; Maltoni, F; Montagna, G; Nason, P; Nicrosini, O; Oleari, C; Piccinini, F; Riva, F; Vicini, A

    This review summarizes the results of the activities which have taken place in 2014 within the Standard Model Working Group of the "What Next" Workshop organized by INFN, Italy. We present a framework, general questions, and some indications of possible answers on the main issue for Standard Model physics in the LHC era and in view of possible future accelerators.

  2. The ATLAS Experiment: Getting Ready for the LHC

    SciTech Connect

    Jenni, Peter

    2006-05-15

    At CERN the Large Hadron Collider (LHC) project is well advanced. First proton-proton collisions at the high-energy frontier are expected for the second half of 2007. In parallel to the collider construction the powerful general-purpose ATLAS detector is being assembled in its underground cavern by a world-wide collaboration. ATLAS will explore new domains of particle physics. After briefly overviewing the LHC construction and installation progress, the status of the ATLAS experiment will be presented, including examples of the exciting prospects for new physics.

  3. First Experiences with LHC Grid Computing and Distributed Analysis

    SciTech Connect

    Fisk, Ian

    2010-12-01

    In this presentation the experiences of the LHC experiments using grid computing were presented with a focus on experience with distributed analysis. After many years of development, preparation, exercises, and validation the LHC (Large Hadron Collider) experiments are in operations. The computing infrastructure has been heavily utilized in the first 6 months of data collection. The general experience of exploiting the grid infrastructure for organized processing and preparation is described, as well as the successes employing the infrastructure for distributed analysis. At the end the expected evolution and future plans are outlined.

  4. Mono-Higgs detection of dark matter at the LHC

    NASA Astrophysics Data System (ADS)

    Berlin, Asher; Lin, Tongyan; Wang, Lian-Tao

    2014-06-01

    Motivated by the recent discovery of the Higgs boson, we investigate the possibility that a missing energy plus Higgs final state is the dominant signal channel for dark matter at the LHC. We consider examples of higher-dimension operators where a Higgs and dark matter pair are produced through an off-shell Z or γ, finding potential sensitivity at the LHC to cutoff scales of around a few hundred GeV. We generalize this production mechanism to a simplified model by introducing a Z' as well as a second Higgs doublet, where the pseudoscalar couples to dark matter. Resonant production of the Z' which decays to a Higgs plus invisible particles gives rise to a potential mono-Higgs signal. This may be observable at the 14 TeV LHC at low tan β and when the Z' mass is roughly in the range 600 GeV to 1.3 TeV.

  5. Parton distributions with LHC data

    NASA Astrophysics Data System (ADS)

    Ball, Richard D.; Bertone, Valerio; Carrazza, Stefano; Deans, Christopher S.; Del Debbio, Luigi; Forte, Stefano; Guffanti, Alberto; Hartland, Nathan P.; Latorre, José I.; Rojo, Juan; Ubiali, Maria; Nnpdf Collaboration

    2013-02-01

    We present the first determination of parton distributions of the nucleon at NLO and NNLO based on a global data set which includes LHC data: NNPDF2.3. Our data set includes, besides the deep inelastic, Drell-Yan, gauge boson production and jet data already used in previous global PDF determinations, all the relevant LHC data for which experimental systematic uncertainties are currently available: ATLAS and LHCb W and Z rapidity distributions from the 2010 run, CMS W electron asymmetry data from the 2011 run, and ATLAS inclusive jet cross-sections from the 2010 run. We introduce an improved implementation of the FastKernel method which allows us to fit to this extended data set, and also to adopt a more effective minimization methodology. We present the NNPDF2.3 PDF sets, and compare them to the NNPDF2.1 sets to assess the impact of the LHC data. We find that all the LHC data are broadly consistent with each other and with all the older data sets included in the fit. We present predictions for various standard candle cross-sections, and compare them to those obtained previously using NNPDF2.1, and specifically discuss the impact of ATLAS electroweak data on the determination of the strangeness fraction of the proton. We also present collider PDF sets, constructed using only data from HERA, the Tevatron and the LHC, but find that this data set is neither precise nor complete enough for a competitive PDF determination.

  6. An Introduction to the LHC Olympics

    NASA Astrophysics Data System (ADS)

    Larkoski, Andrew; Armour, Kyle; Gray, Amanda; Ventura, Dan; Walsh, Jon; Schabinger, Rob

    2006-05-01

    The LHC Olympics is a series of workshop aimed at encouraging theorists and experimentalists to prepare for the soon-to-be-online Large Hadron Collider in Geneva, Switzerland. One aspect of the LHC Olympics program consists of the study of simulated data sets which represent various possible new physics signals as they would be seen in LHC detectors. Through this exercise, LHC Olympians learn the phenomenology of possible new physics models and gain experience in analyzing LHC data. Additionally, the LHC Olympics encourages discussion between theorists and experimentalists, and through this collaboration new techniques could be developed. The University of Washington LHC Olympics group consists of several first-year graduate and senior undergraduate students, in both theoretical and experimental particle physics. Presented here is an introduction to how such an LHC Olympics study is done. Various basic analysis tools and techniques are discussed.

  7. Higgs CP properties from early LHC data

    NASA Astrophysics Data System (ADS)

    Freitas, A.; Schwaller, P.

    2013-03-01

    In this paper, we constrain CP violation in the Higgs sector using the measured signal strengths in the various Higgs search channels. To this end, we introduce a general parametrization for a resonance which is an admixture of a CP-even Higgs-like state and a CP-odd scalar. By performing a fit to the available data from the Tevatron and LHC experiments, one obtains constraints on the mixing angle and the couplings of the resonance to Standard Model fields. Depending on the couplings, sizable mixing angles are still compatible with the data, but small mixing is in general preferred by the fit. In particular, we find that a pure CP-odd state is disfavored by the current data at the 3σ level. Additionally, we consider a mixed fermiophobic resonance and a model with two degenerate mixed resonances and find that both scenarios can successfully fit the data within current errors. Finally, we estimate that the mixing angle can be constrained to α<1.1 (0.7) in the full 8 TeV (14 TeV) run of the LHC.

  8. Simplified limits on resonances at the LHC

    NASA Astrophysics Data System (ADS)

    Chivukula, R. Sekhar; Ittisamai, Pawin; Mohan, Kirtimaan; Simmons, Elizabeth H.

    2016-11-01

    In the earliest stages of evaluating new collider data, especially if a small excess may be present, it would be useful to have a method for comparing the data with entire classes of models, to get an immediate sense of which classes could conceivably be relevant. In this paper, we propose a method that applies when the new physics invoked to explain the excess corresponds to the production and decay of a single, relatively narrow, s -channel resonance. A simplifed model of the resonance allows us to convert an estimated signal cross section into general bounds on the product of the branching ratios corresponding to the dominant production and decay modes. This quickly reveals whether a given class of models could possibly produce a signal of the required size at the LHC. Our work sets up a general framework, outlines how it operates for resonances with different numbers of production and decay modes, and analyzes cases of current experimental interest, including resonances decaying to dibosons, diphotons, dileptons, or dijets. If the LHC experiments were to report their searches for new resonances beyond the standard model in the simplified limits variable ζ defined in this paper, that would make it far easier to avoid blind alleys and home in on the most likely candidate models to explain any observed excesses.

  9. Impact of a CP-violating Higgs sector: from LHC to baryogenesis.

    PubMed

    Shu, Jing; Zhang, Yue

    2013-08-30

    We observe a generic connection between LHC Higgs data and electroweak baryogenesis: the particle that contributes to the CP-odd hgg or hγγ vertex would provide the CP-violating source during a first-order phase transition. It is illustrated in the two Higgs doublet model that a common complex phase controls the lightest Higgs properties at the LHC, electric dipole moments, and the CP-violating source for electroweak baryogenesis. We perform a general parametrization of Higgs effective couplings and a global fit to the LHC Higgs data. Current LHC measurements prefer a nonzero phase for tanβ≲1 and electric dipole moment constraints still allow an order-one phase for tanβ∼1, which gives sufficient room to generate the correct cosmic baryon asymmetry. We also give some prospects in the direct measurements of CP violation in the Higgs sector at the LHC.

  10. Melatonin Attenuates Memory Impairment Induced by Klotho Gene Deficiency Via Interactive Signaling Between MT2 Receptor, ERK, and Nrf2-Related Antioxidant Potential

    PubMed Central

    Shin, Eun-Joo; Chung, Yoon Hee; Le, Hoang-Lan Thi; Jeong, Ji Hoon; Dang, Duy-Khanh; Nam, Yunsung; Wie, Myung Bok; Nah, Seung-Yeol; Nabeshima, Yo-Ichi; Nabeshima, Toshitaka; Kim, Hyoung-Chun

    2015-01-01

    Background: We demonstrated that oxidative stress plays a crucial role in cognitive impairment in klotho mutant mice, a genetic model of aging. Since down-regulation of melatonin due to aging is well documented, we used this genetic model to determine whether the antioxidant property of melatonin affects memory impairment. Methods: First, we examined the effects of melatonin on hippocampal oxidative parameters and the glutathione/oxidized glutathione (GSH/GSSG) ratio and memory dysfunction of klotho mutant mice. Second, we investigated whether a specific melatonin receptor is involved in the melatonin-mediated pharmacological response by application with melatonin receptor antagonists. Third, we examined phospho-extracellular-signal-regulated kinase (ERK) expression, nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation, Nrf2 DNA binding activity, and glutamate-cysteine ligase (GCL) mRNA expression. Finally, we examined effects of the ERK inhibitor SL327 in response to antioxidant efficacy and memory enhancement mediated by melatonin. Results: Treatment with melatonin resulted in significant attenuations of oxidative damage, a decrease in the GSH/GSSG ratio, and a significant amelioration of memory impairment in this aging model. These effects of melatonin were significantly counteracted by the selective MT2 receptor antagonist 4-P-PDOT. Importantly, 4-P-PDOT or SL327 also counteracted melatonin-mediated attenuation in response to the decreases in phospho-ERK expression, Nrf2 nuclear translocation, Nrf2 DNA-binding activity, and GCL mRNA expression in the hippocampi of klotho mutant mice. SL327 also counteracted the up-regulation of the GSH/GSSG ratio and the memory enhancement mediated by melatonin in klotho mutant mice. Conclusions: Melatonin attenuates oxidative stress and the associated memory impairment induced by klotho deficiency via signaling interaction between the MT2 receptor and ERK- and Nrf2-related antioxidant potential. PMID

  11. Enhancement of high glucose-induced PINK1 expression by melatonin stimulates neuronal cell survival: Involvement of MT2 /Akt/NF-κB pathway.

    PubMed

    Onphachanh, Xaykham; Lee, Hyun Jik; Lim, Jae Ryong; Jung, Young Hyun; Kim, Jun Sung; Chae, Chang Woo; Lee, Sei-Jung; Gabr, Amr Ahmed; Han, Ho Jae

    2017-09-01

    Hyperglycemia is a representative hallmark and risk factor for diabetes mellitus (DM) and is closely linked to DM-associated neuronal cell death. Previous investigators reported on a genome-wide association study and showed relationships between DM and melatonin receptor (MT), highlighting the role of MT signaling by assessing melatonin in DM. However, the role of MT signaling in DM pathogenesis is unclear. Therefore, we investigated the role of mitophagy regulators in high glucose-induced neuronal cell death and the effect of melatonin against high glucose-induced mitophagy regulators in neuronal cells. In our results, high glucose significantly increased PTEN-induced putative kinase 1 (PINK1) and LC-3B expressions; as well it decreased cytochrome c oxidase subunit 4 expression and Mitotracker™ fluorescence intensity. Silencing of PINK1 induced mitochondrial reactive oxygen species (ROS) accumulation and mitochondrial membrane potential impairment, increased expressions of cleaved caspases, and increased the number of annexin V-positive cells. In addition, high glucose-stimulated melatonin receptor 1B (MTNR1B) mRNA and PINK1 expressions were reversed by ROS scavenger N-acetyl cysteine pretreatment. Upregulation of PINK1 expression in neuronal cells is suppressed by pretreatment with MT2 receptor-specific inhibitor 4-P-PDOT. We further showed melatonin stimulated Akt phosphorylation, which was followed by nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) phosphorylation and nuclear translocation. Silencing of PINK1 expression abolished melatonin-regulated mitochondrial ROS production, cleaved caspase-3 and caspase-9 expressions, and the number of annexin V-positive cells. In conclusion, we have demonstrated the melatonin stimulates PINK1 expression via an MT2 /Akt/NF-κB pathway, and such stimulation is important for the prevention of neuronal cell apoptosis under high glucose conditions. © 2017 The Authors. Journal of Pineal Research

  12. B Physics at the LHC

    SciTech Connect

    Gersabeck, Marco

    2010-02-10

    The LHC is scheduled to start its first physics data taking period later in 2009. Primarily LHCb but also ATLAS and CMS will start a rich B physics programme with the potential of revealing New Physics in the heavy flavour sector. This contribution will cover the prospects for B physics at the LHC with particular emphasis to early measurements. This includes CP violation measurements in B{sub d}{sup 0} and B{sub s}{sup 0} decays, searches for rare decays such as B{sub s}{sup 0}->{mu}{mu}, as well as semileptonic and radiative channels.

  13. LHC Symposium 2003: Summary Talk

    SciTech Connect

    Jeffrey A. Appel

    2003-08-12

    This summary talk reviews the LHC 2003 Symposium, focusing on expectations as we prepare to leap over the current energy frontier into new territory. We may learn from what happened in the two most recent examples of leaping into new energy territory. Quite different scenarios appeared in those two cases. In addition, they review the status of the machine and experiments as reported at the Symposium. Finally, I suggest an attitude which may be most appropriate as they look forward to the opportunities anticipated for the first data from the LHC.

  14. L'Aventure du LHC

    SciTech Connect

    2010-06-11

    Cette présentation s’adressera principalement aux personnes qui ont construit le LHC. La construction du LHC fut longue et difficile. De nombreux problèmes sont apparus en cours de route. Tous ont été résolus grâce au dévouement et à l’engagement du personnel et des collaborateurs. Je reviendrai sur les coups durs et les réussites qui ont marqués ces 15 dernières années et je vous montrerai combien cette machine, le fruit de vos efforts, est extraordinaire.

  15. LHC: The Large Hadron Collider

    ScienceCinema

    Lincoln, Don

    2016-07-12

    The Large Hadron Collider (or LHC) is the world’s most powerful particle accelerator. In 2012, scientists used data taken by it to discover the Higgs boson, before pausing operations for upgrades and improvements. In the spring of 2015, the LHC will return to operations with 163% the energy it had before and with three times as many collisions per second. It’s essentially a new and improved version of itself. In this video, Fermilab’s Dr. Don Lincoln explains both some of the absolutely amazing scientific and engineering properties of this modern scientific wonder.

  16. Electroweak physics at the LHC

    NASA Astrophysics Data System (ADS)

    Berryhill, J.; Oh, A.

    2017-02-01

    The Large Hadron Collider (LHC) has completed in 2012 its first running phase and the experiments have collected data sets of proton-proton collisions at center-of-mass energies of 7 and 8 TeV with an integrated luminosity of about 5 and 20 {{fb}}-1, respectively. Analyses of these data sets have produced a rich set of results in the electroweak sector of the standard model. This article reviews the status of electroweak measurements of the ATLAS, CMS and LHCb experiments at the LHC.

  17. LHC: The Large Hadron Collider

    SciTech Connect

    Lincoln, Don

    2015-03-04

    The Large Hadron Collider (or LHC) is the world’s most powerful particle accelerator. In 2012, scientists used data taken by it to discover the Higgs boson, before pausing operations for upgrades and improvements. In the spring of 2015, the LHC will return to operations with 163% the energy it had before and with three times as many collisions per second. It’s essentially a new and improved version of itself. In this video, Fermilab’s Dr. Don Lincoln explains both some of the absolutely amazing scientific and engineering properties of this modern scientific wonder.

  18. Diffraction dissociation at the LHC

    SciTech Connect

    Jenkovszky, Laszlo; Orava, Risto; Salii, Andrii

    2013-04-15

    We report on recent calculations of low missing mass single (SD) and double (DD) diffractive dissociation at LHC energies. The calculations are based on a dual-Regge model, dominated by a single Pomeron exchange. The diffractively excited states lie on the nucleon trajectory N*, appended by the isolated Roper resonance. Detailed predictions for the squared momentum transfer and missing mass dependence of the differential and integrated single-and double diffraction dissociation in the kinematical range of present and future LHC measurements are given.

  19. The − 5 A/G single-nucleotide polymorphism in the core promoter region of MT2A and its effect on allele-specific gene expression and Cd, Zn and Cu levels in laryngeal cancer

    SciTech Connect

    Starska, Katarzyna; Krześlak, Anna; Forma, Ewa; Morawiec-Sztandera, Alina; Aleksandrowicz, Paweł; Lewy-Trenda, Iwona; and others

    2014-10-15

    Metallothioneins (MTs) are low molecular weight, cysteine-rich heavy metal-binding proteins which participate in the mechanisms of Zn homeostasis, and protect against toxic metals. MTs contain metal-thiolate cluster groups and suppress metal toxicity by binding to them. The aim of this study was to determine the − 5 A/G (rs28366003) single-nucleotide polymorphism (SNP) in the core promoter region of the MT2A gene and to investigate its effect on allele-specific gene expression and Cd, Zn and Cu content in squamous cell laryngeal cancer (SCC) and non-cancerous laryngeal mucosa (NCM) as a control. The MT2A promoter region − 5 A/G SNP was determined by restriction fragment length polymorphism using 323 SCC and 116 NCM. MT2A gene analysis was performed by quantitative real-time PCR. The frequency of A allele carriage was 94.2% and 91.8% in SCC and NCM, respectively, while G allele carriage was detected in 5.8% and 8.2% of SCC and NCM samples, respectively. As a result, a significant association was identified between the − 5 A/G SNP in the MT2A gene with mRNA expression in both groups. Metal levels were analyzed by flame atomic absorption spectrometry. The significant differences were identified between A/A and both the A/G and G/G genotypes, with regard to the concentration of the contaminating metal. The Spearman rank correlation results showed that the MT2A expression and Cd, Zn, Cu levels were negatively correlated. Results obtained in this study suggest that − 5 A/G SNP in MT2A gene may have an effect on allele-specific gene expression and accumulation of metal levels in laryngeal cancer. - Highlights: • MT2A gene expression and metal content in laryngeal cancer tissues • Association between SNP (rs28366003) and expression of MT2A • Significant associations between the SNP and Cd, Zn and Cu levels • Negative correlation between MT2A gene expression and Cd, Zn and Cu levels.

  20. LHC Higgs signatures from extended electroweak gauge symmetry

    NASA Astrophysics Data System (ADS)

    Abe, Tomohiro; Chen, Ning; He, Hong-Jian

    2013-01-01

    We study LHC Higgs signatures from the extended electroweak gauge symmetry SU(2) ⊗ SU(2) ⊗ U(1). Under this gauge structure, we present an effective UV completion of the 3-site moose model with ideal fermion delocalization, which contains two neutral Higgs states ( h, H) plus three new gauge bosons ( W ' , Z '). We study the unitarity, and reveal that the exact E 2 cancellation in the longitudinal V L V L scattering amplitudes is achieved by the joint role of exchanging both spin-1 new gauge bosons W ' /Z ' and spin-0 Higgs bosons h/H. We identify the lighter Higgs state h with mass 125 GeV, and derive the unitarity bound on the mass of heavier Higgs boson H. The parameter space of this model is highly predictive. We study the production and decay signals of this 125 GeV Higgs boson h at the LHC. We demonstrate that the h Higgs boson can naturally have enhanced signals in the diphoton channel gg → h → γγ, while the event rates in the reactions gg → h → W W ∗ and gg → h → ZZ ∗ are generally suppressed relative to the SM expectation. Searching the h Higgs boson via the associated production and the vector boson fusions are also discussed for our model. We further analyze the LHC signals of the heavier Higgs boson H as a new physics discriminator from the SM. For wide mass-ranges of H, we derive constraints from the existing LHC searches, and study the discovery potential of H at the LHC (8 TeV) and LHC (14 TeV).

  1. Probing baryogenesis with displaced vertices at the LHC

    NASA Astrophysics Data System (ADS)

    Cui, Yanou; Shuve, Brian

    2015-02-01

    The generation of the asymmetric cosmic baryon abundance requires a departure from thermal equilibrium in the early universe. In a large class of baryogenesis models, the baryon asymmetry results from the out-of-equilibrium decay of a new, massive particle. We highlight that in the interesting scenario where this particle has a weak scale mass, this out-of-equilibrium condition requires a proper decay length larger than O(1) mm. Such new fields are within reach of the LHC, at which they can be pair produced leaving a distinctive, displaced-vertex signature. This scenario is realized in the recently proposed mechanism of baryogenesis where the baryon asymmetry is produced through the freeze-out and subsequent decay of a meta-stable weakly interacting massive particle ("WIMP baryogenesis"). In analogy to missing energy searches for WIMP dark matter, the LHC is an excellent probe of these new long-lived particles responsible for baryogenesis via the low-background displaced vertex channel. In our paper, we estimate the limits on simplified models inspired by WIMP baryogenesis from two of the most sensitive collider searches by CMS and ATLAS with 8 TeV LHC data. We also estimate the LHC reach at 13 TeV using current strategies, and demonstrate that up to a factor of 100 improvement in cross-section limits can be achieved by requiring two displaced vertices while lowering kinematic thresholds. For meta-stable WIMPs produced through electroweak interactions, the high luminosity LHC is sensitive to masses up to 2.5 TeV for lifetimes around 1 cm, while for singlets pair-produced through the off-shell-Higgs portal, the LHC is sensitive to production cross sections of O(10) ab for benchmark masses around 150 GeV. Our analysis and proposals also generally apply to displaced vertex signatures from other new physics such as hidden valley models, twin Higgs models and displaced supersymmetry.

  2. Inelastic diffraction at the LHC

    NASA Astrophysics Data System (ADS)

    Troshin, S. M.; Tyurin, N. E.

    2017-03-01

    The relativistic scattering was one of the scientific fields where Academician V.G. Kadyshevsky has made an important and highly cited contribution [1]. In this paper we discuss the high-energy dependencies of diffractive and non-diffractive inelastic cross-sections in view of the recent LHC data which reveal a presence of the reflective scattering mode.

  3. The history of the LHC

    ScienceCinema

    None

    2016-07-12

    Abstract: From the civil engineering, to the manufacturing of the various magnet types, each building block of this extraordinary machine required ambitious leaps in innovation. This lecture will review the history of the LHC project, focusing on the many challenges -- scientific, technological, managerial -- that had to be met during the various phases of R&D;, industrialization, construction, installation and commissioning.

  4. String Physics at the LHC

    SciTech Connect

    Anchordoqui, Luis A.

    2008-11-23

    The LHC program will include the identification of events with single high-k{sub T} photons as probes of new physics. We show that this channel is uniquely suited to search for experimental evidence of TeV-scale open string theory.

  5. Heavy Quark Photoproduction at LHC

    NASA Astrophysics Data System (ADS)

    Gonçalves, V. P.; Meneses, A. R.; Machado, M. V.

    2010-11-01

    In this work we calculate the inclusive and difractive photoproduction of heavy quarks in proton-proton collisions at LHC energies within the color dipole picture employing three phenomenological saturation models based on the color glass condensate formalism. Our results demonstrate that the experimental analyzes of these reactions is feasible and that the cross sections are sensitive to the underlying parton dynamics.

  6. PHOBOS in the LHC era

    SciTech Connect

    Steinberg, Peter

    2015-01-15

    The PHOBOS experiment ran at the RHIC collider from 2000 to 2005, under the leadership of Wit Busza. These proceedings summarize selected PHOBOS results, highlighting their continuing relevance amidst the wealth of new results from the lead–lead program at the Large Hadron Collider (LHC)

  7. Diphoton resonances at the LHC

    NASA Astrophysics Data System (ADS)

    Molinaro, Emiliano; Vignaroli, Natascia

    2017-09-01

    We review the current status of searches for new physics beyond the Standard Model in the diphoton channel at the LHC and estimate the reach with future collected data. We perform a model independent analysis based on an effective field theory approach and different production mechanisms. As an illustrative example, we apply our results to a scenario of minimal composite dynamics.

  8. Patterns of strong coupling for LHC searches

    NASA Astrophysics Data System (ADS)

    Liu, Da; Pomarol, Alex; Rattazzi, Riccardo; Riva, Francesco

    2016-11-01

    Even though the Standard Model (SM) is weakly coupled at the Fermi scale, a new strong dynamics involving its degrees of freedom may conceivably lurk at slightly higher energies, in the multi TeV range. Approximate symmetries provide a structurally robust context where, within the low energy description, the dimensionless SM couplings are weak, while the new strong dynamics manifests itself exclusively through higher-derivative interactions. We present an exhaustive classification of such scenarios in the form of effective field theories, paying special attention to new classes of models where the strong dynamics involves, along with the Higgs boson, the SM gauge bosons and/or the fermions. The IR softness of the new dynamics suppresses its effects at LEP energies, but deviations are in principle detectable at the LHC, even at energies below the threshold for production of new states. We believe our construction provides the so far unique structurally robust context where to motivate several LHC searches in Higgs physics, diboson production, or W W scattering. Perhaps surprisingly, the interplay between weak coupling, strong coupling and derivatives, which is controlled by symmetries, can override the naive expansion in operator dimension, providing instances where dimension-8 dominates dimension-6, well within the domain of validity of the low energy effective theory. This result reveals the limitations of an analysis that is both ambitiously general and restricted to dimension-6 operators.

  9. Genetic deletion of MT1 and MT2 melatonin receptors differentially abrogates the development and expression of methamphetamine-induced locomotor sensitization during the day and the night in C3H/HeN mice

    PubMed Central

    Hutchinson, Anthony J.; Hudson, Randall L.; Dubocovich, Margarita L.

    2013-01-01

    This study explored the role of the melatonin receptors in methamphetamine (METH)-induced locomotor sensitization during the light and dark phases in C3H/HeN mice with genetic deletion of theMT1 and/or MT2 melatonin receptors. Six daily treatments with METH (1.2 mg/kg, i.p.) in a novel environment during the light phase led to the development of locomotor sensitization in wild-type (WT), MT1KO and MT2KO mice. Following four full days of abstinence, METH challenge (1.2 mg/kg, i.p.) triggered the expression of locomotor sensitization in METH-pretreated but not in vehicle (VEH)-pretreated mice. In MT1/MT2KO mice, the development of sensitization during the light phase was significantly reduced and the expression of sensitization was completely abrogated upon METH challenge. During the dark phase the development of locomotor sensitization in METH-pretreated WT, MT1KO and MT2KO mice was statistically different from VEH-treated controls. However, WT and MT2KO, but not MT1KO mice receiving repeated VEH pretreatments during the dark phase expressed a sensitized response to METH challenge that is of an identical magnitude to that observed upon 6 days of METH pretreatment. We conclude that exposure to a novel environment during the dark phase, but not during the light phase, facilitated the expression of sensitization to a METH challenge in a manner dependent on MT1 melatonin receptor activation by endogenous melatonin. We suggest that MT1 and MT2 melatonin receptors are potential targets for pharmacotherapeutic intervention in METH abusers. PMID:22672659

  10. The energy dependence of the diffraction minimum in the elastic scattering and new LHC data

    NASA Astrophysics Data System (ADS)

    Selyugin, O. V.

    2017-03-01

    The soft diffraction phenomena in the elastic proton-proton scattering are reviewed from the viewpoint of experiments at the LHC (TOTEM and ATLAS collaboration). In the framework of the High Energy Generalized Structure (HEGS) model the form of the diffraction minimum in the nucleon-nucleon elastic scattering in a wide energy region is analyzed. The energy dependencies of the main characteristics of the diffraction dip are obtained. The numerical predictions at LHC energies are presented. The comparison of the model predictions with the new LHC data at √{ s} = 13 TeV is made.

  11. Le LHC, un tunnel cosmique

    ScienceCinema

    None

    2016-07-12

    Et si la lumière au bout du tunnel du LHC était cosmique ? En d’autres termes, qu’est-ce que le LHC peut nous apporter dans la connaissance de l’Univers ? Car la montée en énergie des accélérateurs de particules nous permet de mieux appréhender l’univers primordial, chaud et dense. Mais dans quel sens dit-on que le LHC reproduit des conditions proches du Big bang ? Quelles informations nous apporte-t-il sur le contenu de l’Univers ? La matière noire est-elle détectable au LHC ? L’énergie noire ? Pourquoi l’antimatière accumulée au CERN est-elle si rare dans l’Univers ? Et si le CERN a bâti sa réputation sur l’exploration des forces faibles et fortes qui opèrent au sein des atomes et de leurs noyaux, est-ce que le LHC peut nous apporter des informations sur la force gravitationnelle qui gouverne l’évolution cosmique ? Depuis une trentaine d’années, notre compréhension de l’univers dans ses plus grandes dimensions et l’appréhension de son comportement aux plus petites distances sont intimement liées : en quoi le LHC va-t-il tester expérimentalement cette vision unifiée ? Tout public, entrée libre / Réservations au +41 (0)22 767 76 76

  12. Testing the Muon g-2 Anomaly at the LHC

    DOE PAGES

    Freitas, Ayres; Lykken, Joseph; Kell, Stefan; ...

    2014-05-29

    The long-standing difference between the experimental measurement and the standard-model prediction for the muon's anomalous magnetic moment,more » $$a_{\\mu} = (g_{\\mu}-2)/2$$, may be explained by the presence of new weakly interacting particles with masses of a few 100 GeV. Particles of this kind can generally be directly produced at the LHC, and thus they may already be constrained by existing data. In this work, we investigate this connection between $$a_{\\mu}$$ and the LHC in a model-independent approach, by introducing one or two new fields beyond the standard model with spin and weak isospin up to one. For each case, we identify the preferred parameter space for explaining the discrepancy of a_mu and derive bounds using data from LEP and the 8-TeV LHC run. Furthermore, we estimate how these limits could be improved with the 14-TeV LHC. We find that the 8-TeV results already rule out a subset of our simplified models, while almost all viable scenarios can be tested conclusively with 14-TeV data.« less

  13. 125 GeV Technidilaton at the LHC

    NASA Astrophysics Data System (ADS)

    Matsuzaki, Shinya

    The technidilaton (TD) is a composite scalar predicted in walking technicolor (WTC), arising as a pseudo Nambu-Goldstone boson associated with the spontaneous breaking of the approximate scale invariance. Due to the Nambu-Goldstone boson's nature, the TD can be as light as the LHC boson that has been discovered at around 125 GeV. We discuss the size of the TD mass and the coupling properties relevant to the LHC study. It turns out that the TD couplings to the standard model (SM) particles take the same form as those of the SM Higgs boson, except the essentially distinguishable two ingredients: i) the overall coupling strengths set by the decay constant related to the spontaneous breaking of the scale invariance, which is in general not equal to the electroweak scale; ii) the couplings to photons and gluons which can include extra contributions from technifermion loops and hence can be enhanced compared to the SM Higgs case. To be concrete, we take the one-family technicolor model to explore the TD LHC phenomenology at 125 GeV. It is shown that the TD gives the signal consistent with the currently reported LHC data, notably can explain the excess in the diphoton channel, due to the extra contributions to digluon and diphoton couplings coming from the one-family technifermion loops.

  14. Testing the Muon g-2 Anomaly at the LHC

    SciTech Connect

    Freitas, Ayres; Lykken, Joseph; Kell, Stefan; Westhoff, Susanne

    2014-05-29

    The long-standing difference between the experimental measurement and the standard-model prediction for the muon's anomalous magnetic moment, $a_{\\mu} = (g_{\\mu}-2)/2$, may be explained by the presence of new weakly interacting particles with masses of a few 100 GeV. Particles of this kind can generally be directly produced at the LHC, and thus they may already be constrained by existing data. In this work, we investigate this connection between $a_{\\mu}$ and the LHC in a model-independent approach, by introducing one or two new fields beyond the standard model with spin and weak isospin up to one. For each case, we identify the preferred parameter space for explaining the discrepancy of a_mu and derive bounds using data from LEP and the 8-TeV LHC run. Furthermore, we estimate how these limits could be improved with the 14-TeV LHC. We find that the 8-TeV results already rule out a subset of our simplified models, while almost all viable scenarios can be tested conclusively with 14-TeV data.

  15. The Role of US Groups in LHC Physics

    NASA Astrophysics Data System (ADS)

    Green, Daniel

    2009-05-01

    U.S. groups have been involved in the LHC for the last fifteen years and have participated in the design, construction, installation and commissioning of the ATLAS and CMS detectors and the LHC accelerator. During this period U.S. groups have been integral to the overall effort and indeed comprise the largest national group within the detector collaborations. In the future these groups will take on operations tasks and R&D plans for detector upgrades. Thus, the U.S. effort will be an extended commitment, decades long. Nevertheless, the methods whereby U.S. groups will play a proportionate role in the physics analyses are less clear. LHC data and computing resources will be spread worldwide. What collaborative tools will allow U.S. groups to fully participate in the expected rich LHC physics? Should there be multiple analysis centers within the large and distributed ATLAS and CMS collaborations? As high energy physics looks ahead to having fewer energy frontier facilities similar issues will arise in the future which makes these questions of more general interest.

  16. Toxicity of synthetic herbicides containing 2,4-D and MCPA moieties towards Pseudomonas putida mt-2 and its response at the level of membrane fatty acid composition.

    PubMed

    Piotrowska, Aleksandra; Syguda, Anna; Chrzanowski, Łukasz; Heipieper, Hermann J

    2016-02-01

    One of the attempts to create more effective herbicidal compounds includes the use of ionic liquids. Herbicidal ionic liquids have more effective biological activity, they are less volatile, more thermally stable, and exhibit superior efficiency in comparison to typically employed herbicides, allowing the reduction of the herbicide dose applied per hectare. However, studies on the environmental toxicity of this group of compounds are very rarely available. Environmental toxicity is an important factor, showing the concentration of compounds that has negative effects on soil bacteria including those responsible for biodegradation processes. Therefore, potential toxicity of four herbicidal ionic liquids (HILs) precursors containing 2,4-D and MCPA moieties was tested with the well investigated model organism for toxicity and adaptation, Pseudomonas putida mt-2. Results were compared to those obtained for commercial 2,4-D and MCPA herbicides. Next to growth inhibition, given as EC50, changes in the isomerisation of cis to trans unsaturated fatty acids were applied as proxy for cellular stress adaptation to toxic substances. The results revealed that all investigated precursors of HILs showed lower toxicity compared to commercialized synthetic herbicides 2,4-D and MCPA. The collected data on toxicity of HILs together with their physico-chemical properties might be useful for assessing the potential risk of the environmental pollution as well as guidelines for setting the legislation for their future use.

  17. Plutonium interaction studies with the Mont Terri Opalinus Clay isolate Sporomusa sp. MT-2.99: changes in the plutonium speciation by solvent extractions.

    PubMed

    Moll, Henry; Cherkouk, Andrea; Bok, Frank; Bernhard, Gert

    2017-04-07

    Since plutonium could be released from nuclear waste disposal sites, the exploration of the complex interaction processes between plutonium and bacteria is necessary for an improved understanding of the fate of plutonium in the vicinity of such a nuclear waste disposal site. In this basic study, the interaction of plutonium with cells of the bacterium, Sporomusa sp. MT-2.99, isolated from Mont Terri Opalinus Clay, was investigated anaerobically (in 0.1 M NaClO4) with or without adding Na-pyruvate as an electron donor. The cells displayed a strong pH-dependent affinity for Pu. In the absence of Na-pyruvate, a strong enrichment of stable Pu(V) in the supernatants was discovered, whereas Pu(IV) polymers dominated the Pu oxidation state distribution on the biomass at pH 6.1. A pH-dependent enrichment of the lower Pu oxidation states (e.g., Pu(III) at pH 6.1 which is considered to be more mobile than Pu(IV) formed at pH 4) was observed in the presence of up to 10 mM Na-pyruvate. In all cases, the presence of bacterial cells enhanced removal of Pu from solution and accelerated Pu interaction reactions, e.g., biosorption and bioreduction.

  18. The impact of succinate trace on pWW0 and ortho-cleavage pathway transcription in Pseudomonas putida mt-2 during toluene biodegradation.

    PubMed

    Tsipa, Argyro; Koutinas, Michalis; Vernardis, Spyros I; Mantalaris, Athanasios

    2017-06-01

    Toluene is a pollutant catabolised through the interconnected pWW0 (TOL) and ortho-cleavage pathways of Pseudomonas putida mt-2, while upon succinate and toluene mixtures introduction in batch cultures grown on M9 medium, succinate was previously reported as non-repressing. The effect of a 40 times lower succinate concentration, as compared to literature values, was explored through systematic real-time qPCR monitoring of transcriptional kinetics of the key TOL Pu, Pm and ortho-cleavage PbenR, PbenA promoters in mixed-substrate experiments. Even succinate trace inhibited transcription leading to bi-modal promoters expression. Potential carbon catabolite repression mechanisms and novel expression patterns of promoters were unfolded. Lag phase was shortened and biomass growth levels increased compared to sole toluene biodegradation suggesting enhanced pollutant removal efficiency. The study stressed the noticeable effect of a preferred compound's left-over on the main route of a bioprocess, revealing the beneficiary supply of low preferred substrates concentrations to design optimal bioremediation strategies. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. A new perspective in Oral health: potential importance and actions of melatonin receptors MT1, MT2, MT3, and RZR/ROR in the oral cavity.

    PubMed

    Cutando, Antonio; Aneiros-Fernández, Jose; López-Valverde, Antonio; Arias-Santiago, Salvador; Aneiros-Cachaza, Jose; Reiter, Russel J

    2011-10-01

    Melatonin is involved in many physiological processes in mammals, amongst others; it is implicated in sleep-wake regulation. It has antioxidant and anti-inflammatory properties. It also acts as an immunomodulator, stimulates bone metabolism and inhibits various tumours. Additionally an abnormal melatonin rhythm may contribute to depression and insomnia. The mechanisms of action of melatonin include the involvement of membrane receptors (MT1, MT2), cytosolic binding sites (MT3 and calmodulin), and nuclear receptors of the RZR/ROR family. Melatonin also has receptor-independent activity and can directly scavenge free radicals. The current review addresses the functions of melatonin in the oral cavity in relation to its receptors. An extensive search was conducted on the following scientific databases Pub Med, Science Direct, ISI Web of Knowledge and Cochrane database in order to review all pertinent literature. Melatonin from the blood into the saliva may play an important role in suppressing oral diseases. It may have beneficial effects in periodontal disease, herpes and oral cancer, amongst others. Melatonin contributes to protecting of oral cavity from tissue damage due to its action of different receptors. From the reviewed literature it is concluded that experimental evidence suggests that melatonin can be useful in treating several common diseases of the oral cavity. Specific studies are necessary to extend the therapeutic possibilities of melatonin to other oral diseases. Copyright © 2011 Elsevier Ltd. All rights reserved.

  20. Medium chain length polyhydroxyalkanoates biosynthesis in Pseudomonas putida mt-2 is enhanced by co-metabolism of glycerol/octanoate or fatty acids mixtures.

    PubMed

    Fontaine, Paul; Mosrati, Ridha; Corroler, David

    2017-05-01

    The synthesis of medium chain length polyhydroxyalkanoates (mcl-PHAs) by Pseudomonas putida mt-2 was investigated under nitrogen-rich then deficient conditions with glycerol/octanoate or long-chain fatty acids (LCFAs) as carbon sources. When mixed, glycerol and octanoate were co-assimilated regardless of nitrogen availability but provided that glycerol uptake has been already triggered under non-limiting nutrient conditions. This concomitant consumption allowed to enhance mcl-PHAs accumulation (up to 57% of cell dry weight (CDW)) under both non-limiting and nitrogen deficient conditions. Octanoate then mostly drove anabolism of the polyester with 3-hydroxyoctanoate (3HO) synthesized as the main monomer (83%). If the preferred PHA precursor octanoate was supplied, glycerol was mainly involved in cell growth and/or maintenance but very little in PHA production even under nitrogen starvation. P. putida cells accumulated higher amounts of mcl-PHAs when grown on mixtures of LCFAs compared to LCFAs supplied as single substrate (25% and 9% of CDW, respectively). However, only a weak enrichment of the polyester was observed after transfer of cells in a fresh nitrogen-free medium containing the same combination of LCFAs. Some typical units within the polyester were related to the LCFAs ratio supplied in the medium indicating that tailor-made monomers could be synthesized. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Enhancement of regulatory T cell-like suppressive function in MT-2 by long-term and low-dose exposure to asbestos.

    PubMed

    Ying, Chen; Maeda, Megumi; Nishimura, Yasumitsu; Kumagai-Takei, Naoko; Hayashi, Hiroaki; Matsuzaki, Hidenori; Lee, Suni; Yoshitome, Kei; Yamamoto, Shoko; Hatayama, Tamayo; Otsuki, Takemi

    2015-12-02

    Asbestos exposure causes lung fibrosis and various malignant tumors such as lung cancer and malignant mesothelioma. The effects of asbestos on immune cells have not been thoroughly investigated, although our previous reports showed that asbestos exposure reduced anti-tumor immunity. The effects of continuous exposure of regulatory T cells (Treg) to asbestos were examined using the HTLV-1 immortalized human T cell line MT-2, which possesses a suppressive function and expresses the Treg marker protein, Foxp3. Sublines were generated by the continuous exposure to low doses of asbestos fibers for more than one year. The sublines exposed to asbestos showed enhanced suppressive Treg function via cell-cell contact, and increased production of soluble factors such as IL-10 and transforming growth factor (TGF)-β1. These results also indicated that asbestos exposure induced the reduction of anti-tumor immunity, and efforts to develop substances to reverse this reduction may be helpful in preventing the occurrence of asbestos-induced tumors.

  2. Naturalness in the dark at the LHC

    NASA Astrophysics Data System (ADS)

    Craig, Nathaniel; Katz, Andrey; Strassler, Matt; Sundrum, Raman

    2015-07-01

    We revisit the Twin Higgs scenario as a "dark" solution to the little hierarchy problem, identify the structure of a minimal model and its viable parameter space, and analyze its collider implications. In this model, dark naturalness generally leads to Hidden Valley phenomenology. The twin particles, including the top partner, are all Standard-Model-neutral, but naturalness favors the existence of twin strong interactions — an asymptotically-free force that confines not far above the Standard Model QCD scale — and a Higgs portal interaction. We show that, taken together, these typically give rise to exotic decays of the Higgs to twin hadrons. Across a substantial portion of the parameter space, certain twin hadrons have visible and often displaced decays, providing a potentially striking LHC signature. We briefly discuss appropriate experimental search strategies.

  3. L'Aventure du LHC

    ScienceCinema

    None

    2016-07-12

    Cette présentation s’adressera principalement aux personnes qui ont construit le LHC. La construction du LHC fut longue et difficile. De nombreux problèmes sont apparus en cours de route. Tous ont été résolus grâce au dévouement et à l’engagement du personnel et des collaborateurs. Je reviendrai sur les coups durs et les réussites qui ont marqués ces 15 dernières années et je vous montrerai combien cette machine, le fruit de vos efforts, est extraordinaire.

  4. Catching Collisions in the LHC

    SciTech Connect

    Fruguiele, Claudia; Hirschauer, Jim

    2015-06-16

    Now that the Large Hadron Collider has officially turned back on for its second run, within every proton collision could emerge the next new discovery in particle physics. Learn how the detectors on the Compact Muon Solenoid, or CMS, experiment capture and track particles as they are expelled from a collision. Talking us through these collisions are Claudia Fruguiele and Jim Hirschauer of Fermi National Accelerator Laboratory, the largest U.S. institution collaborating on the LHC.

  5. Catching Collisions in the LHC

    ScienceCinema

    Fruguiele, Claudia; Hirschauer, Jim

    2016-07-12

    Now that the Large Hadron Collider has officially turned back on for its second run, within every proton collision could emerge the next new discovery in particle physics. Learn how the detectors on the Compact Muon Solenoid, or CMS, experiment capture and track particles as they are expelled from a collision. Talking us through these collisions are Claudia Fruguiele and Jim Hirschauer of Fermi National Accelerator Laboratory, the largest U.S. institution collaborating on the LHC.

  6. hhjj production at the LHC

    DOE PAGES

    Dolan, Matthew J.; Englert, Christoph; Greiner, Nicolas; ...

    2015-08-25

    The search for di-Higgs production at the LHC in order to set limits on the Higgs trilinear coupling and constraints on new physics is one of the main motivations for the LHC high-luminosity phase. Recent experimental analyses suggest that such analyses will only be successful if information from a range of channels is included. We therefore investigate di-Higgs production in association with two hadronic jets and give a detailed discussion of both the gluon- and the weak boson-fusion (WBF) contributions, with a particular emphasis on the phenomenology with modified Higgs trilinear and quartic gauge couplings. We perform a detailed investigationmore » of the full hadronic final state and find that hhjj production should add sensitivity to a di-Higgs search combination at the HL-LHC with 3 ab-1. Since the WBF and GF contributions are sensitive to different sources of physics beyond the Standard Model, we devise search strategies to disentangle and isolate these production modes. In addition, while gluon fusion remains non-negligible in WBF-type selections, sizeable new physics contributions to the latter can still be constrained. As an example of the latter point we investigate the sensitivity that can be obtained for a measurement of the quartic Higgs–gauge boson couplings.« less

  7. Cryogenics for HL-LHC

    NASA Astrophysics Data System (ADS)

    Tavian, L.; Brodzinski, K.; Claudet, S.; Ferlin, G.; Wagner, U.; van Weelderen, R.

    The discovery of a Higgs boson at CERN in 2012 is the start of a major program of work to measure this particle's properties with the highest possible precision for testing the validity of the Standard Model and to search for further new physics at the energy frontier. The LHC is in a unique position to pursue this program. Europe's top priority is the exploitation of the full potential of the LHC, including the high-luminosity upgrade of the machine and detectors with an objective to collect ten times more data than in the initial design, by around 2030. To reach this objective, the LHC cryogenic system must be upgraded to withstand higher beam current and higher luminosity at top energy while keeping the same operation availability by improving the collimation system and the protection of electronics sensitive to radiation. This chapter will present the conceptual design of the cryogenic system upgrade with recent updates in performance requirements, the corresponding layout and architecture of the system as well as the main technical challenges which have to be met in the coming years.

  8. QCD and hard diffraction at the LHC

    SciTech Connect

    Albrow, Michael G.; /Fermilab

    2005-09-01

    As an introduction to QCD at the LHC the author gives an overview of QCD at the Tevatron, emphasizing the high Q{sup 2} frontier which will be taken over by the LHC. After describing briefly the LHC detectors the author discusses high mass diffraction, in particular central exclusive production of Higgs and vector boson pairs. The author introduces the FP420 project to measure the scattered protons 420m downstream of ATLAS and CMS.

  9. Highlights from LHC experiments and future perspectives

    SciTech Connect

    Campana, P.

    2016-01-22

    The experiments at LHC are collecting a large amount of data in a kinematic of the (x, Q{sup 2}) variables never accessed before. Boosted by LHC analyses, Quantum Chromodynamics (QCD) is experiencing an impressive progress in the last few years, and even brighter perspectives can be foreseen for the future data taking. A subset of the most recent results from the LHC experiments in the area of QCD (both perturbative and soft) are reviewed.

  10. Flavor in heavy neutrino searches at the LHC

    NASA Astrophysics Data System (ADS)

    Aguilar-Saavedra, J. A.; Deppisch, F.; Kittel, O.; Valle, J. W. F.

    2012-05-01

    Heavy neutrinos at the TeV scale have been searched for at the LHC in the context of left-right models, under the assumption that they couple to the electron, the muon, or both. We show that current searches are also sensitive to heavy neutrinos coupling predominantly to the tau lepton, and present limits can significantly constrain the parameter space of general flavor mixing.

  11. High Stability and Fast Recovery of Expression of the TOL Plasmid-Carried Toluene Catabolism Genes of Pseudomonas putida mt-2 under Conditions of Oxygen Limitation and Oscillation▿ †

    PubMed Central

    Martínez-Lavanchy, Paula M.; Müller, Christina; Nijenhuis, Ivonne; Kappelmeyer, Uwe; Buffing, Marieke; McPherson, Kyle; Heipieper, Hermann J.

    2010-01-01

    Pseudomonas putida mt-2 harbors the TOL plasmid (pWWO), which contains the genes encoding the enzymes necessary to degrade toluene aerobically. The xyl genes are clustered in the upper operon and encode the enzymes of the upper pathway that degrade toluene to benzoate, while the genes encoding the enzymes of the lower pathway (meta-cleavage pathway) that are necessary for the conversion of benzoate to tricarboxylic acid cycle intermediates, are encoded in a separate operon. In this study, the effects of oxygen availability and oscillation on the expression of catabolic genes for enzymes involved in toluene degradation were studied by using P. putida mt-2 as model bacterium. Quantitative reverse transcription-PCR was used to detect and quantify the expression of the catabolic genes xylM (a key gene of the upper pathway) and xylE (a key gene of the lower pathway) in cultures of P. putida mt-2 that were grown with toluene as a carbon source. Toluene degradation was shown to have a direct dependency on oxygen concentration, where gene expression of xylM and xylE decreased due to oxygen depletion during degradation. Under oscillating oxygen concentrations, P. putida mt-2 induced or downregulated xylM and xylE genes according to the O2 availability in the media. During anoxic periods, P. putida mt-2 decreased the expression of xylM and xylE genes, while the expression of both xylM and xylE genes was immediately increased after oxygen became available again in the medium. These results suggest that oxygen is not only necessary as a cosubstrate for enzyme activity during the degradation of toluene but also that oxygen modulates the expression of the catabolic genes encoded by the TOL plasmid. PMID:20709833

  12. Characteristic and Expression Analysis of a Metallothionein Gene, OsMT2b, Down-Regulated by Cytokinin Suggests Functions in Root Development and Seed Embryo Germination of Rice1[OA

    PubMed Central

    Yuan, Jing; Chen, Dan; Ren, Yujun; Zhang, Xuelian; Zhao, Jie

    2008-01-01

    Metallothioneins (MTs) are low molecular mass and cysteine-rich metal-binding proteins known to be mainly involved in maintaining metal homeostasis and stress responses. But, their functions in higher plant development are scarcely studied. Here, we characterized rice (Oryza sativa) METALLOTHIONEIN2b (OsMT2b) molecularly and found that its expression was down-regulated by cytokinins. OsMT2b was preferentially expressed in rice immature panicles, scutellum of germinating embryos, and primordium of lateral roots. In contrast with wild-type plants, OsMT2b-RNA interference (RNAi) transgenic plants had serious handicap in plant growth and root formation, whereas OsMT2b-overexpressing transformants were dwarfed and presented more adventitious roots and big lateral roots. The increased cytokinin levels in RNAi plants and decreased cytokinin levels in overexpressing plants were confirmed by high-performance liquid chromatography quantitative analysis in the roots of wild-type and transgenic plants. In RNAi plants, localization of isopentenyladenosine, a kind of endogenous cytokinin, in roots and germinating embryos expanded to the whole tissues, whereas in overexpressing plants, the isopentenyladenosine signals were very faint in the vascular tissues of roots and scutellum cells of germinating embryos. In vitro culture of embryos could largely resume the reduced germination frequency in RNAi plants but had no obvious change in overexpressing plants. Taken together, these results indicate a possible feedback regulation mechanism of OsMT2b to the level of endogenous cytokinins that is involved in root development and seed embryo germination of rice. PMID:18258694

  13. LHC crab-cavity aspects and strategy

    SciTech Connect

    Calaga, R.; Tomas, R.; Zimmermann, F.

    2010-05-23

    The 3rd LHC Crab Cavity workshop (LHC-CC09) took place at CERN in October 2009. It reviewed the current status and identified a clear strategy towards a future crab-cavity implementation. Following the success of crab cavities in KEK-B and the strong potential for luminosity gain and leveling, CERN will pursue crab crossing for the LHC upgrade. We present a summary and outcome of the variousworkshop sessions which have led to the LHC crab-cavity strategy, covering topics like layout, cavity design, integration, machine protection, and a potential validation test in the SPS.

  14. Abort Gap Cleaning for LHC Run 2

    SciTech Connect

    Uythoven, Jan; Boccardi, Andrea; Bravin, Enrico; Goddard, Brennan; Hemelsoet, Georges-Henry; Höfle, Wolfgang; Jacquet, Delphine; Kain, Verena; Mazzoni, Stefano; Meddahi, Malika; Valuch, Daniel; Gianfelice-Wendt, Eliana

    2014-07-01

    To minimize the beam losses at the moment of an LHC beam dump the 3 μs long abort gap should contain as few particles as possible. Its population can be minimised by abort gap cleaning using the LHC transverse damper system. The LHC Run 1 experience is briefly recalled; changes foreseen for the LHC Run 2 are presented. They include improvements in the observation of the abort gap population and the mechanism to decide if cleaning is required, changes to the hardware of the transverse dampers to reduce the detrimental effect on the luminosity lifetime and proposed changes to the applied cleaning algorithms.

  15. Purification and properties of catechol 1,2-dioxygenase (pyrocatechase) from Pseudomonas putida mt-2 in comparison with that from Pseudomonas arvilla C-1.

    PubMed

    Nakai, C; Nakazawa, T; Nozaki, M

    1988-12-01

    Catechol 1,2-dioxygenase (pyrocatechase) has been purified to homogeneity from Pseudomonas putida mt-2. Most properties of this enzyme, such as the absorption spectrum, iron content, pH stability, pH optimum, substrate specificity, Km values, and amino acid composition, were similar to those of catechol 1,2-dioxygenase obtained from Pseudomonas arvilla C-1 [Y. Kojima et al. (1967) J. Biol. Chem. 242, 3270-3278]. These two catechol 1,2-dioxygenases were also found, from the results of Ouchterlony double diffusion, to share several antigenic determinants. The molecular weight of the putida enzyme was estimated to be 66,000 and 64,000 by sedimentation equilibrium analysis and Sephadex G-200 gel filtration, respectively. The enzyme gave a single band on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, corresponding to Mr 32,000. The NH2-terminal sequence, which started with threonine, was determined up to 30 residues by Edman degradation. During the degradation, a single amino acid was released at each step. The NH2-terminal sequence up to 20 residues was identical to that of the beta subunit of the arvilla enzyme, with one exception at step 16, at which arginine was observed instead of glutamine. The COOH-terminal residue was deduced to be arginine on carboxypeptidase A and B digestions and on hydrazinolysis. These results indicate that the putida enzyme consists of two identical subunits, in contrast to the arvilla enzyme which consists of two nonidentical subunits, alpha and beta [C. Nakai et al. (1979) Arch. Biochem. Biophys. 195, 12-22], although these two enzymes have very similar properties.

  16. K{sub T} effect in the W boson associative production of the Higgs at the LHC

    SciTech Connect

    Benhizia, K.; Mebarki, N.; Boudine, A.

    2012-06-27

    A make a qualitative study of the K{sub T} effect in the Higgs associative production with a W vector boson at the LHC. The kinematics are presented and the generalized form of the cross section is obtained.

  17. MSSM forecast for the LHC

    NASA Astrophysics Data System (ADS)

    Cabrera, Maria Eugenia; Casas, J. Alberto; de Austri, Roberto Ruiz

    2010-05-01

    We perform a forecast of the MSSM with universal soft terms (CMSSM) for the LHC, based on an improved Bayesian analysis. We do not incorporate ad hoc measures of the fine-tuning to penalize unnatural possibilities: such penalization arises from the Bayesian analysis itself when the experimental value of M Z is considered. This allows to scan the whole parameter space, allowing arbitrarily large soft terms. Still the low-energy region is statistically favoured (even before including dark matter or g-2 constraints). Contrary to other studies, the results are almost unaffected by changing the upper limits taken for the soft terms. The results are also remarkable stable when using flat or logarithmic priors, a fact that arises from the larger statistical weight of the low-energy region in both cases. Then we incorporate all the important experimental constrains to the analysis, obtaining a map of the probability density of the MSSM parameter space, i.e. the forecast of the MSSM. Since not all the experimental information is equally robust, we perform separate analyses depending on the group of observables used. When only the most robust ones are used, the favoured region of the parameter space contains a significant portion outside the LHC reach. This effect gets reinforced if the Higgs mass is not close to its present experimental limit and persits when dark matter constraints are included. Only when the g-2 constraint (based on e + e - data) is considered, the preferred region (for μ > 0) is well inside the LHC scope. We also perform a Bayesian comparison of the positive- and negative- μ possibilities.

  18. LHC Status and Upgrade Challenges

    NASA Astrophysics Data System (ADS)

    Smith, Jeffrey

    2009-11-01

    The Large Hadron Collider has had a trying start-up and a challenging operational future lays ahead. Critical to the machine's performance is controlling a beam of particles whose stored energy is equivalent to 80 kg of TNT. Unavoidable beam losses result in energy deposition throughout the machine and without adequate protection this power would result in quenching of the superconducting magnets. A brief overview of the machine layout and principles of operation will be reviewed including a summary of the September 2008 accident. The current status of the LHC, startup schedule and upgrade options to achieve the target luminosity will be presented.

  19. Z' Phenomenology and the LHC

    SciTech Connect

    Rizzo, Thomas G.

    2006-10-17

    A brief pedagogical overview of the phenomenology of Z{prime} gauge bosons is ILC in determining Z{prime} properties is also discussed. and explore in detail how the LHC may discover and help elucidate the models, review the current constraints on the possible properties of a Z{prime} nature of these new particles. We provide an overview of the Z{prime} studies presented. Such particles can arise in various electroweak extensions of that have been performed by both ATLAS and CMS. The role of the the Standard Model (SM). We provide a quick survey of a number of Z{prime}.

  20. b' search at the LHC

    SciTech Connect

    Holdom, Bob; Yan Qishu

    2011-11-01

    We consider the production and detection of a sequential, down type quark via the mode pp{yields}b'b-bar'{yields}W{sup +}W{sup -}tt-bar{yields}l{nu}{sub l}8j at the LHC, with the collision energy {radical}(s)=10 TeV and the total integrated luminosity around 1 fb{sup -1}. We assume m{sub b'}=m{sub t'}=600 GeV. A full reconstruction is employed and the signal and background discrimination is studied within a neural network approach. Our results show that this mode can make a useful contribution to the b' search.

  1. Radiation hard electronics for LHC

    NASA Astrophysics Data System (ADS)

    Raymond, M.; Millmore, M.; Hall, G.; Sachdeva, R.; French, M.; Nygård, E.; Yoshioka, K.

    1995-02-01

    A CMOS front end electronics chain is being developed by the RD20 collaboration for microstrip detector readout at LHC. It is based on a preamplifier and CR-RC filter, analogue pipeline and an analogue signal processor. Amplifiers and transistor test structures have been constructed and evaluated in detail using a Harris 1.2 μm radiation hardened CMOS process. Progress with larger scale elements, including 32 channel front end chips, is described. A radiation hard 128 channel chip, with a 40 MHz analogue multiplexer, is to be submitted for fabrication in July 1994 which will form the basis of the readout of the tracking system of the CMS experiment.

  2. (SUSY) Higgs Search at the LHC

    SciTech Connect

    Muehlleitner, M. Margarete

    2008-11-23

    The discovery of the Standard Model (SM) or supersymmetric (SUSY) Higgs bosons belongs to the main endeavors of the Large Hadron Collider (LHC). In this article the status of the signal and background calculations for Higgs boson production at the LHC is reviewed.

  3. First data from TOTEM experiment at LHC

    SciTech Connect

    Ferro, F.

    2011-07-15

    The TOTEM experiment at the LHC is mainly dedicated to the measurement of the total proton-proton cross section, elastic scattering and to the study of the diffractive processes. This contribution reviews the physics goals of the experiment, the status of the experimental apparatus and of the analysis of the first data from the LHC.

  4. Diffraction from HERA to the LHC

    SciTech Connect

    Newman, Paul

    2011-07-15

    Following a 15 year programme of intensive research into diffractive electron-proton scattering at HERA, it is important to transfer the knowledge and experience gained into the LHC programme. This contribution raises some current issues in diffraction at the LHC and suggests ways in which they might be addressed using HERA results.

  5. Gauge mediation at the LHC: status and prospects

    NASA Astrophysics Data System (ADS)

    Knapen, Simon; Redigolo, Diego

    2017-01-01

    We show that the predictivity of general gauge mediation (GGM) with TeV-scale stops is greatly increased once the Higgs mass constraint is imposed. The most notable results are a strong lower bound on the mass of the gluino and right-handed squarks, and an upper bound on the Higgsino mass. If the μ-parameter is positive, the wino mass is also bounded from above. These constraints relax significantly for high messenger scales and as such long-lived NLSPs are favored in GGM. We identify a small set of most promising topologies for the neutralino/sneutrino NLSP scenarios and estimate the impact of the current bounds and the sensitivity of the high luminosity LHC. The stau, stop and sbottom NLSP scenarios can be robustly excluded at the high luminosity LHC.

  6. Experimental status of supersymmetry after the LHC Run-I

    NASA Astrophysics Data System (ADS)

    Autermann, Christian

    2016-09-01

    The ATLAS and CMS experiments at the Large Hadron Collider (LHC) at CERN have searched for signals of new physics, in particular for supersymmetry. The data collected until 2012 at center-of-mass energies of 7 and 8 TeV and integrated luminosities of 5 fb-1 and 20 fb-1, respectively, agree with the expectation from standard model processes. Constraints on supersymmetry have been calculated and interpreted in different models. Limits on supersymmetry particle masses at the TeV scale have been derived and interpreted generally in the context of simplified model spectra. The constrained minimal supersymmetric standard model is disfavored by the experimental results. Natural supersymmetry scenarios with low supersymmetry particle masses remain possible in multiple regions, for example in those with compressed spectra, that are difficult to access experimentally. The upgraded LHC operating at √{ s } = 13 TeV is gaining sensitivity to the remaining unexplored SUSY parameter space.

  7. Gauge mediation at the LHC: status and prospects

    DOE PAGES

    Knapen, Simon; Redigolo, Diego

    2017-01-30

    We show that the predictivity of general gauge mediation (GGM) with TeV-scale stops is greatly increased once the Higgs mass constraint is imposed. The most notable results are a strong lower bound on the mass of the gluino and right-handed squarks, and an upper bound on the Higgsino mass. If the μ-parameter is positive, the wino mass is also bounded from above. These constraints relax significantly for high messenger scales and as such long-lived NLSPs are favored in GGM. We identify a small set of most promising topologies for the neutralino/sneutrino NLSP scenarios and estimate the impact of the currentmore » bounds and the sensitivity of the high luminosity LHC. The stau, stop and sbottom NLSP scenarios can be robustly excluded at the high luminosity LHC.« less

  8. Multi-Boson Interactions at the Run 1 LHC

    SciTech Connect

    Green, Daniel R.; Meade, Patrick; Pleier, Marc-Andre

    2016-10-24

    This review article covers results on the production of all possible electroweak boson pairs and 2-to-1 vector boson fusion (VBF) at the CERN Large Hadron Collider (LHC) in proton-proton collisions at a center-of-mass energy of 7 TeV and 8 TeV. The data was taken between 2010 and 2012. Limits on anomalous triple gauge couplings (aTGCs) then follow. In addition, data on electroweak triple gauge boson production and 2-to-2 vector boson scattering (VBS) yield limits on anomalous quartic gauge boson couplings (aQGCs). The LHC hosts two general purpose experiments, ATLAS and CMS, which both have reported limits on aTGCs and aQGCs which are herein summarized. The interpretation of these limits in terms of an effective field theory (EFT) is reviewed, and recommendations are made for testing other types of new physics using multi-gauge boson production.

  9. Remote Operations for LHC and CMS

    SciTech Connect

    Gottschalk, E.E.; /Fermilab

    2007-04-01

    Commissioning the Large Hadron Collider (LHC) and its experiments will be a vital part of the worldwide high energy physics program beginning in 2007. A remote operations center has been built at Fermilab to contribute to commissioning and operations of the LHC and the Compact Muon Solenoid (CMS) experiment, and to develop new capabilities for real-time data analysis and monitoring for LHC, CMS, and grid computing. Remote operations will also be essential to a future International Linear Collider with its multiple, internationally distributed control rooms. In this paper we present an overview of Fermilab's LHC@FNAL remote operations center for LHC and CMS, describe what led up to the development of the center, and describe noteworthy features of the center.

  10. Tax posttranslational modifications and interaction with calreticulin in MT-2 cells and human peripheral blood mononuclear cells of human T cell lymphotropic virus type-I-associated myelopathy/tropical spastic paraparesis patients.

    PubMed

    Medina, Fernando; Quintremil, Sebastian; Alberti, Carolina; Barriga, Andres; Cartier, Luis; Puente, Javier; Ramírez, Eugenio; Ferreira, Arturo; Tanaka, Yuetsu; Valenzuela, Maria Antonieta

    2014-04-01

    The human retrovirus human T cell lymphotropic virus type-I (HTLV-1) is the etiologic agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Axonal degeneration in HAM/TSP patients occurs without neuron infection, with the secreted viral Tax protein proposed to be involved. We previously found that Tax secreted into the culture medium of MT-2 cells (HTLV-1-infected cell line) produced neurite retraction in neuroblastoma cells differentiated to neuronal type. To assess the relevance of Tax posttranslational modifications on this effect, we addressed the question of whether Tax secreted by MT-2 cells and peripheral blood mononuclear cells (PBMCs) of HTLV-1-infected subjects is modified. The interaction of Tax with calreticulin (CRT) that modulates intracellular Tax localization and secretion has been described. We studied Tax localization and modifications in MT-2 cells and its interaction with CRT. Intracellular Tax in MT-2 cells was assessed by flow cytometry, corresponding mainly to a 71-kDa protein followed by western blot. This protein reported as a chimera with gp21 viral protein-confirmed by mass spectrometry-showed no ubiquitination or SUMOylation. The Tax-CRT interaction was determined by confocal microscopy and coimmunoprecipitation. Extracellular Tax from HAM/TSP PBMCs is ubiquitinated according to western blot, and its interaction with CRT was shown by coimmunoprecipitation. A positive correlation between Tax and CRT secretion was observed in HAM/TSP PBMCs and asymptomatic carriers. For both proteins inhibitors and activators of secretion showed secretion through the endoplasmic reticulum-Golgi complex. Tax, present in PBMC culture medium, produced neurite retraction in differentiated neuroblastoma cells. These results suggest that Tax, whether ubiquitinated or not, is active for neurite retraction.

  11. Tax Posttranslational Modifications and Interaction with Calreticulin in MT-2 Cells and Human Peripheral Blood Mononuclear Cells of Human T Cell Lymphotropic Virus Type-I-Associated Myelopathy/Tropical Spastic Paraparesis Patients

    PubMed Central

    Medina, Fernando; Quintremil, Sebastian; Alberti, Carolina; Barriga, Andres; Cartier, Luis; Puente, Javier; Ramírez, Eugenio; Ferreira, Arturo; Tanaka, Yuetsu

    2014-01-01

    Abstract The human retrovirus human T cell lymphotropic virus type-I (HTLV-1) is the etiologic agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Axonal degeneration in HAM/TSP patients occurs without neuron infection, with the secreted viral Tax protein proposed to be involved. We previously found that Tax secreted into the culture medium of MT-2 cells (HTLV-1-infected cell line) produced neurite retraction in neuroblastoma cells differentiated to neuronal type. To assess the relevance of Tax posttranslational modifications on this effect, we addressed the question of whether Tax secreted by MT-2 cells and peripheral blood mononuclear cells (PBMCs) of HTLV-1-infected subjects is modified. The interaction of Tax with calreticulin (CRT) that modulates intracellular Tax localization and secretion has been described. We studied Tax localization and modifications in MT-2 cells and its interaction with CRT. Intracellular Tax in MT-2 cells was assessed by flow cytometry, corresponding mainly to a 71-kDa protein followed by western blot. This protein reported as a chimera with gp21 viral protein—confirmed by mass spectrometry—showed no ubiquitination or SUMOylation. The Tax–CRT interaction was determined by confocal microscopy and coimmunoprecipitation. Extracellular Tax from HAM/TSP PBMCs is ubiquitinated according to western blot, and its interaction with CRT was shown by coimmunoprecipitation. A positive correlation between Tax and CRT secretion was observed in HAM/TSP PBMCs and asymptomatic carriers. For both proteins inhibitors and activators of secretion showed secretion through the endoplasmic reticulum–Golgi complex. Tax, present in PBMC culture medium, produced neurite retraction in differentiated neuroblastoma cells. These results suggest that Tax, whether ubiquitinated or not, is active for neurite retraction. PMID:24321043

  12. Mirage models confront the LHC. III. Deflected mirage mediation

    NASA Astrophysics Data System (ADS)

    Everett, Lisa L.; Garon, Todd; Kaufman, Bryan L.; Nelson, Brent D.

    2016-03-01

    We complete the study of a class of string-motivated effective supergravity theories in which modulus-induced soft supersymmetry breaking is sufficiently suppressed in the observable sector so as to be competitive with anomaly-mediated supersymmetry breaking. Here we consider deflected "mirage mediation" (DMM), where contributions from gauge mediation are added to those arising from gravity mediation and anomaly mediation. We update previous work that surveyed the rich parameter space of such theories, in light of data from the CERN Large Hadron Collider (LHC) and recent dark matter detection experiments. Constraints arising from LHC superpartner searches at √{s }=8 TeV are considered, and discovery prospects at √{s }=14 TeV are evaluated. We find that deflected mirage mediation generally allows for S U (3 )-charged superpartners of significantly lower mass (given current knowledge of the Higgs mass and neutralino relic density) than was found for the "pure" mirage mediation models of Kachru et al. [Phys. Rev. D 68, 046005 (2003)]. Consequently, discovery prospects are enhanced for many combinations of matter multiplet modular weights. We examine the experimental challenges that will arise due to the prospect of highly compressed spectra in DMM, and the correlation between accessibility at the LHC and discovery prospects at large-scale liquid xenon dark matter detectors.

  13. GUT and supersymmetry at the LHC and in dark matter

    SciTech Connect

    Nath, Pran

    2012-07-27

    Conventional SO(10) models involve more than one scale for a complete breaking of the GUT symmetry requiring further assumptions on the VEVs of the Higgs fields that enter in the breaking to achieve viable models. Recent works where the breaking can be accomplished at one scale are discussed. These include models with just a pair of 144+144 of Higgs fields. Further extensions of this idea utilizing 560+560 of Higgs representations allow both the breaking at one scale, as well as accomplish a natural doublet-triplet splitting via the missing partner mechanism. More generally, we discuss the connection of high scale models to low energy physics in the context of supergravity grand unification. Here we discuss a natural solution to the little hierarchy problem and also discuss the implications of the LHC data for supersymmetry. It is shown that the LHC data implies that most of the parameter space of supergravity models consistent with the data lie on the Hyperbolic Branch of radiative breaking of the electroweak symmetry and more specifically on the Focal Surface of the Hyperbolic Branch. A discussion is also given of the implications of recent LHC data on the Higgs boson mass for the discovery of supersymmetry and for the search for dark matter.

  14. The versatile link, a common project for super-LHC

    SciTech Connect

    Amaral, Luis; Dris, Stefanos; Gerardin, Alexandre; Huffman, Todd; Issever, Cigdem; Pacheco, Alberto Jimenez; Jones, Mark; Kwan, Simon; Lee, Shih-Chang; Lian, Zhijun; Liu, Tiankuan; /CERN /Oxford U. /Fermilab /Taipei, Computing Ctr. /Southern Methodist U.

    2009-07-01

    Radiation tolerant, high speed optoelectronic data transmission links are fundamental building blocks in today's large scale High Energy Physics (HEP) detectors, as exemplified by the four experiments currently under commissioning at the Large Hadron Collider (LHC), see for example. New experiments or upgrades will impose even more stringent demands on these systems from the point of view of performance and radiation tolerance. This can already be seen from the developments underway for the Super Large Hadron Collider (SLHC) project, a proposed upgrade to the LHC aiming at increasing the luminosity of the machine by factor of 10 to 10{sup 35} cm{sup -2}s{sup -1}, and thus providing a better chance to see rare processes and improving statistically marginal measurements. In the past, specific data transmission links have been independently developed by each LHC experiment for data acquisition (DAQ), detector control as well as trigger and timing distribution (TTC). This was justified by the different types of applications being targeted as well as by technological limitations preventing one single solution from fitting all requirements. However with today's maturity of optoelectronic and CMOS technologies it is possible to envisage the development of a general purpose optical link which can cover most transmission applications: a Versatile Link. Such an approach has the clear advantage of concentrating the development effort on one single project targeting an optical link whose final functionality will only result from the topology and configuration settings adopted.

  15. Overview of LHC physics results at ICHEP

    ScienceCinema

    None

    2016-07-12

     This month LHC physics day will review the physics results presented by the LHC experiments at the 2010 ICHEP in Paris. The experimental presentations will be preceeded by the bi-weekly LHC accelerator status report.The meeting will be broadcast via EVO (detailed info will appear at the time of the meeting in the "Video Services" item on the left menu bar)For those attending, information on accommodation, access to CERN and laptop registration is available from http://cern.ch/lpcc/visits

  16. Critical behavior of cross sections at LHC

    NASA Astrophysics Data System (ADS)

    Dremin, I. M.

    2016-07-01

    Recent experimental data on elastic scattering of high energy protons show that the critical regime has been reached at LHC energies. The approach to criticality is demonstrated by increase of the ratio of elastic to total cross sections from ISR to LHC energies. At LHC it reaches the value which can result in principal change of the character of proton interactions. The treatment of new physics of hollowed toroid-like hadrons requires usage of another branch of the unitarity condition. Its further fate is speculated and interpreted with the help of the unitarity condition in combination with present experimental data. The gedanken experiments to distinguish between different possibilities are proposed.

  17. Overview of LHC physics results at ICHEP

    SciTech Connect

    2011-02-25

     This month LHC physics day will review the physics results presented by the LHC experiments at the 2010 ICHEP in Paris. The experimental presentations will be preceeded by the bi-weekly LHC accelerator status report.The meeting will be broadcast via EVO (detailed info will appear at the time of the meeting in the "Video Services" item on the left menu bar)For those attending, information on accommodation, access to CERN and laptop registration is available from http://cern.ch/lpcc/visits

  18. Gluino polarization at the LHC

    SciTech Connect

    Kraemer, M.; Popenda, E.; Spira, M.; Zerwas, P. M.

    2009-09-01

    Gluinos are produced pairwise at the LHC in quark-antiquark and gluon-gluon collisions: qq, gg{yields}g-tildeg-tilde. While the individual polarization of gluinos vanishes in the limit in which the small mass difference between L and R squarks of the first two generations is neglected, nonzero spin-spin correlations are predicted within gluino pairs. If the squark/quark charges in Majorana gluino decays are tagged, the spin correlations have an impact on the energy and angular distributions in reconstructed final states. On the other hand, the gluino polarization in single gluino production in the supersymmetric Compton process gq{yields}g-tildeq-tilde{sub R,L} is predicted to be nonzero, and the polarization affects the final-state distributions in super-Compton events.

  19. HL-LHC and HE-LHC Upgrade Plans and Opportunities for US Participation

    NASA Astrophysics Data System (ADS)

    Apollinari, Giorgio

    2017-01-01

    The US HEP community has identified the exploitation of physics opportunities at the High Luminosity-LHC (HL-LHC) as the highest near-term priority. Thanks to multi-year R&D programs, US National Laboratories and Universities have taken the leadership in the development of technical solutions to increase the LHC luminosity, enabling the HL-LHC Project and uniquely positioning this country to make critical contributions to the LHC luminosity upgrade. This talk will describe the shaping of the US Program to contribute in the next decade to HL-LHC through newly developed technologies such as Nb3Sn focusing magnets or superconducting crab cavities. The experience gained through the execution of the HL-LHC Project in the US will constitute a pool of knowledge and capabilities allowing further developments in the future. Opportunities for US participations in proposed hadron colliders, such as a possible High Energy-LHC (HE-LHC), will be described as well.

  20. Tension in the LHC diffractive data?

    SciTech Connect

    Gotsman, Errol

    2015-04-10

    I discuss the LHC diffractive data, and compare it to predicted energy behaviour of various models. I suggest that the so called 'tension' between the experimental results, maybe due to the different Monte Carlo programs used.

  1. The LHC Confronts the pMSSM

    SciTech Connect

    Cahill-Rowley, Matthew

    2016-05-31

    Here we explore the impact of current (7+8 TeV) and future (14 TeV) LHC searches on the range of viable sparticle spectra within the 19/20 – dimensional phenomenological MSSM (pMSSM). Considering both neutralino and gravitino LSPs, we compare our results with simplified model exclusion limits and describe important cases where the pMSSM results differ significantly from the simplified model descriptions. We also consider models that are poorly constrained by LHC data because of unusual decay topologies and/or displaced decays, and discuss ways to improve the LHC sensitivity in these scenarios. Finally, motivated by naturalness, we examine the sensitivity of current searches to models with light stops and to a specialized set of models with fine-tuning better than 1%. We show that the 14 TeV LHC will be a very powerful probe of natural pMSSM models.

  2. The LHC Confronts the pMSSM

    DOE PAGES

    Cahill-Rowley, Matthew

    2016-05-31

    Here we explore the impact of current (7+8 TeV) and future (14 TeV) LHC searches on the range of viable sparticle spectra within the 19/20 – dimensional phenomenological MSSM (pMSSM). Considering both neutralino and gravitino LSPs, we compare our results with simplified model exclusion limits and describe important cases where the pMSSM results differ significantly from the simplified model descriptions. We also consider models that are poorly constrained by LHC data because of unusual decay topologies and/or displaced decays, and discuss ways to improve the LHC sensitivity in these scenarios. Finally, motivated by naturalness, we examine the sensitivity of currentmore » searches to models with light stops and to a specialized set of models with fine-tuning better than 1%. We show that the 14 TeV LHC will be a very powerful probe of natural pMSSM models.« less

  3. LHC Beam Instrumentation Status and Challenges

    NASA Astrophysics Data System (ADS)

    Jones, Rhodri

    2006-11-01

    This presentation will aim to give an overview of the beam instrumentation foreseen for the LHC. A brief summary of the main systems will be followed by a discussion of areas where there have been recent advances, such as in the measurement of tune, chromaticity and coupling, or where there are still outstanding issues. The instrumentation to be delivered as part of the US LHC Accelerator Research Program (US-LARP) will also be highlighted.

  4. From the LHC to Future Colliders

    SciTech Connect

    De Roeck, A.; Ellis, J.; Grojean, C.; Heinemeyer, S.; Jakobs, K.; Weiglein, G.; Azuelos, G.; Dawson, S.; Gripaios, B.; Han, T.; Hewett, J.; Lancaster, M.; Mariotti, C.; Moortgat, F.; Moortgat-Pick, G.; Polesello, G.; Riemann, S.; Assamagan, K.; Bechtle, P.; Carena, M.; Chachamis, G.; /more authors..

    2010-06-11

    Discoveries at the LHC will soon set the physics agenda for future colliders. This report of a CERN Theory Institute includes the summaries of Working Groups that reviewed the physics goals and prospects of LHC running with 10 to 300 fb{sup -1} of integrated luminosity, of the proposed sLHC luminosity upgrade, of the ILC, of CLIC, of the LHeC and of a muon collider. The four Working Groups considered possible scenarios for the first 10 fb{sup -1} of data at the LHC in which (i) a state with properties that are compatible with a Higgs boson is discovered, (ii) no such state is discovered either because the Higgs properties are such that it is difficult to detect or because no Higgs boson exists, (iii) a missing-energy signal beyond the Standard Model is discovered as in some supersymmetric models, and (iv) some other exotic signature of new physics is discovered. In the contexts of these scenarios, theWorking Groups reviewed the capabilities of the future colliders to study in more detail whatever new physics may be discovered by the LHC. Their reports provide the particle physics community with some tools for reviewing the scientific priorities for future colliders after the LHC produces its first harvest of new physics from multi-TeV collisions.

  5. Introduction to the HL-LHC Project

    NASA Astrophysics Data System (ADS)

    Rossi, L.; Brüning, O.

    The Large Hadron Collider (LHC) is one of largest scientific instruments ever built. It has been exploring the new energy frontier since 2010, gathering a global user community of 7,000 scientists. To extend its discovery potential, the LHC will need a major upgrade in the 2020s to increase its luminosity (rate of collisions) by a factor of five beyond its design value and the integrated luminosity by a factor of ten. As a highly complex and optimized machine, such an upgrade of the LHC must be carefully studied and requires about ten years to implement. The novel machine configuration, called High Luminosity LHC (HL-LHC), will rely on a number of key innovative technologies, representing exceptional technological challenges, such as cutting-edge 11-12 tesla superconducting magnets, very compact superconducting cavities for beam rotation with ultra-precise phase control, new technology for beam collimation and 300-meter-long high-power superconducting links with negligible energy dissipation. HL-LHC federates efforts and R&D of a large community in Europe, in the US and in Japan, which will facilitate the implementation of the construction phase as a global project.

  6. Considerations on Energy Frontier Colliders after LHC

    SciTech Connect

    Shiltsev, Vladimir

    2016-11-15

    Since 1960’s, particle colliders have been in the forefront of particle physics, 29 total have been built and operated, 7 are in operation now. At present the near term US, European and international strategies of the particle physics community are centered on full exploitation of the physics potential of the Large Hadron Collider (LHC) through its high-luminosity upgrade (HL-LHC). The future of the world-wide HEP community critically depends on the feasibility of possible post-LHC colliders. The concept of the feasibility is complex and includes at least three factors: feasibility of energy, feasibility of luminosity and feasibility of cost. Here we overview all current options for post-LHC colliders from such perspective (ILC, CLIC, Muon Collider, plasma colliders, CEPC, FCC, HE-LHC) and discuss major challenges and accelerator R&D required to demonstrate feasibility of an energy frontier accelerator facility following the LHC. We conclude by taking a look into ultimate energy reach accelerators based on plasmas and crystals, and discussion on the perspectives for the far future of the accelerator-based particle physics. This paper largely follows previous study [1] and the presenta ion given at the ICHEP’2016 conference in Chicago [2].

  7. Composite dark matter and LHC interplay

    NASA Astrophysics Data System (ADS)

    Marzocca, David; Urbano, Alfredo

    2014-07-01

    The actual realization of the electroweak symmetry breaking in the context of a natural extension of the Standard Model (SM) and the nature of Dark Matter (DM) are two of the most compelling questions in high-energy particle physics. Composite Higgs models may provide a unified picture in which both the Higgs boson and the DM particle arise as pseudo Nambu-Goldstone bosons of a spontaneously broken global symmetry at a scale f ˜ TeV. In this paper we analyze a general class of these models based on the coset SO(6) /SO(5). Assuming the existence of light and weakly coupled spin-1 and spin-1/2 resonances which mix linearly with the elementary SM particles, we are able to compute the effective potential of the theory by means of some generalized Weinberg sum rules. The properties of the Higgs boson, DM, top quark and the above resonances are thus calculable and tightly connected. We perform a wide phenomenological analysis, considering both collider physics at the LHC and astrophysical observables. We find that these models are tightly constrained by present experimental data, which are able to completely exclude the most natural setup with f ≃ 800 GeV. Upon increasing the value of f , an allowed region appears. In particular for f ≃ 1 .1 TeV we find a concrete realization that predicts m DM ≃ 200 GeV for the DM mass. This DM candidate lies close to the present sensitivity of direct detection experiments and will be ruled out — or discovered — in the near future.

  8. Revised LHC deal quiets congress

    SciTech Connect

    Lawler, A.

    1997-05-23

    The roughest part of the ride may be over for U.S. physicists who want to participate in the Large Hadron Collider (LHC), the $5 billion accelerator planned for CERN in Geneva. They have found themselves on a political roller coaster for the past few months. This week, U.S. and European negotiators were putting the final touches on a revamped agreement that should pave the way for the United States to help pay for construction of the accelerator and its two main detectors, and guarantee U.S. scientists a role in research on the machine. The trouble began in March, when Representative Joe Barton (R-TX) declared war on a proposed $530 million U.S. contribution to the new facility, slated for completion in 2005. Barton and many other members of Congress were still smarting from what they said was a lack of European support for the canceled Superconducting Super Collider that was being built in Barton`s backyard. Representative James Sensenbrenner (R-WI), who chairs the House Science Committee, led the charge to alter a draft agreement initialed this winter by Department of Energy (DOE) and CERN officials that spelled out the details of U.S. participation. After hurried negotiations, both sides have sharpened the agreement to address the lawmakers` concerns. The new deal, says Energy Secretary Federico Pena, {open_quotes}has made that project even better.{close_quotes}

  9. Bilepton signatures at the LHC

    NASA Astrophysics Data System (ADS)

    Corcella, Gennaro; Corianò, Claudio; Costantini, Antonio; Frampton, Paul H.

    2017-10-01

    We discuss the main signatures of the Bilepton Model at the Large Hadron Collider, focusing on its gauge boson sector. The model is characterised by five additional gauge bosons, four charged and one neutral, beyond those of the Standard Model, plus three exotic quarks. The latter turn into ordinary quarks with the emission of bilepton doublets (Y++ ,Y+) and (Y- ,Y-) of lepton number L = - 2 and L = + 2 respectively, with the doubly-charged bileptons decaying into same-sign lepton pairs. We perform a phenomenological analysis investigating processes with two doubly-charged bileptons and two jets at the LHC and find that, setting suitable cuts on pseudorapidities and transverse momenta of final-states jets and leptons, the model yields a visible signal and the main Standard Model backgrounds can be suppressed. Compared to previous studies, our investigation is based on a full Monte Carlo implementation of the model and accounts for parton showers, hadronization and an actual jet-clustering algorithm for both signal and Standard Model background, thus providing an optimal framework for an actual experimental search.

  10. Jet charge at the LHC.

    PubMed

    Krohn, David; Schwartz, Matthew D; Lin, Tongyan; Waalewijn, Wouter J

    2013-05-24

    Knowing the charge of the parton initiating a light-quark jet could be extremely useful both for testing aspects of the standard model and for characterizing potential beyond-the-standard-model signals. We show that despite the complications of hadronization and out-of-jet radiation such as pileup, a weighted sum of the charges of a jet's constituents can be used at the LHC to distinguish among jets with different charges. Potential applications include measuring electroweak quantum numbers of hadronically decaying resonances or supersymmetric particles, as well as standard model tests, such as jet charge in dijet events or in hadronically decaying W bosons in tt[over ¯] events. We develop a systematically improvable method to calculate moments of these charge distributions by combining multihadron fragmentation functions with perturbative jet functions and pertubative evolution equations. We show that the dependence on energy and jet size for the average and width of the jet charge can be calculated despite the large experimental uncertainty on fragmentation functions. These calculations can provide a validation tool for data independent of Monte Carlo fragmentation models.

  11. Hadron colliders (SSC/LHC)

    SciTech Connect

    Chao, A.W.; Palmer, R.B. |; Evans, L.; Gareyte, J.; Siemann, R.H.

    1992-12-31

    The nominal SSC and LHC designs should operate conservatively at luminosities up to 10{sup 33} cm{sup {minus}2} s{sup {minus}1}. This luminosity is dictated by the event rates that can be handled by the detectors. However, this limit is event dependent (e.g. it does not take much of a detector to detect the event pp {yields} elephant; all one needs is extremely high luminosity). As such, it is useful to explore the possibility of going beyond the 10{sup 33} cm{sup {minus}2} s{sup {minus}1} level. Such exploration will also improve the accelerator physics understanding of pp collider designs. If the detector limitations are removed, the first accelerator limits occur when the luminosity is at the level of 10{sup 34} cm{sup {minus}2}s{sup {minus}1}. These accelerator limits will first be reviewed. The authors will then continue on to explore even higher luminosity as the ultimate limit of pp colliders. Accelerator technologies needed to achieve this ultimate luminosity as well as the R and D needed to reach it are discussed.

  12. Gaugino physics of split supersymmetry spectra at the LHC and future proton colliders

    NASA Astrophysics Data System (ADS)

    Jung, Sunghoon; Wells, James D.

    2014-04-01

    Discovery of the Higgs boson and lack of discovery of superpartners in the first run at the LHC are both predictions of split supersymmetry with thermal dark matter. We discuss what it would take to find gluinos at hadron supercolliders, including the LHC at 14 TeV center-of-mass energy, and future pp colliders at 100 TeV and 200 TeV. We generalize the discussion by reexpressing the search capacity in terms of the gluino to lightest superpartner mass ratio and apply results to other scenarios, such as gauge mediation and mirage mediation.

  13. The MoEDAL experiment at the LHC: status and results

    NASA Astrophysics Data System (ADS)

    Mitsou, Vasiliki A.; MoEDAL Collaboration

    2017-07-01

    The MoEDAL experiment at the LHC is optimised to detect highly ionising particles such as magnetic monopoles, dyons and (multiply) electrically charged stable massive particles predicted in a number of theoretical scenarios. MoEDAL, deployed in the LHCb cavern, combines passive nuclear track detectors with magnetic monopole trapping volumes (MMTs), while spallation-product backgrounds are being monitored with an array of MediPix pixel detectors. An introduction to the detector concept and its physics reach, complementary to that of the large general purpose LHC experiments ATLAS and CMS, will be given. Emphasis is given to the recent MoEDAL results at 13 TeV, where the null results from a search for magnetic monopoles in MMTs exposed in 2015 LHC collisions set the world-best limits on particles with magnetic charges more than 1.5 Dirac charge. The potential to search for heavy, long-lived supersymmetric electrically-charged particles is also discussed.

  14. $A^t_{FB}$ Meets LHC

    SciTech Connect

    Hewett, JoAnne L.; Shelton, Jessie; Spannowsky, Michael; Tait, Tim M.P.; Takeuchi, Michihisa; /Heidelberg U.

    2012-02-14

    The recent Tevatron measurement of the forward-backward asymmetry of the top quark shows an intriguing discrepancy with Standard Model expectations, particularly at large t{bar t} invariant masses. Measurements of this quantity are subtle at the LHC, due to its pp initial state, however, one can define a forward-central-charge asymmetry which captures the physics. We study the capability of the LHC to measure this asymmetry and find that within the SM a measurement at the 5{sigma} level is possible with roughly 60 fb{sup -1} at {radical}s = 14 TeV. If nature realizes a model which enhances the asymmetry (as is necessary to explain the Tevatron measurements), a significant difference from zero can be observed much earlier, perhaps even during early LHC running at {radical}s = 7 TeV. We further explore the capabilities of the 7 TeV LHC to discover resonances or contact interactions which modify the t{bar t} invariant mass distribution using recent boosted top tagging techniques. We find that TeV-scale color octet resonances can be discovered, even with small coupling strengths and that contact interactions can be probed at scales exceeding 6 TeV. Overall, the LHC has good potential to clarify the situation with regards to the Tevatron forward-backward measurement.

  15. High Luminosity LHC: challenges and plans

    NASA Astrophysics Data System (ADS)

    Arduini, G.; Barranco, J.; Bertarelli, A.; Biancacci, N.; Bruce, R.; Brüning, O.; Buffat, X.; Cai, Y.; Carver, L. R.; Fartoukh, S.; Giovannozzi, M.; Iadarola, G.; Li, K.; Lechner, A.; Medina Medrano, L.; Métral, E.; Nosochkov, Y.; Papaphilippou, Y.; Pellegrini, D.; Pieloni, T.; Qiang, J.; Redaelli, S.; Romano, A.; Rossi, L.; Rumolo, G.; Salvant, B.; Schenk, M.; Tambasco, C.; Tomás, R.; Valishev, S.; Van der Veken, F. F.

    2016-12-01

    The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up a new energy frontier for exploration in 2010, it has gathered a global user community working in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. To sustain and extend its discovery potential, the LHC will undergo a major upgrade in the 2020s. This will increase its rate of collisions by a factor of five beyond the original design value and the integrated luminosity by a factor ten. The new configuration, known as High Luminosity LHC (HL-LHC), will rely on a number of key innovations that push accelerator technology beyond its present limits. Among these are cutting-edge 11-12 T superconducting magnets, including Nb3Sn-based magnets never used in accelerators before, compact superconducting cavities for longitudinal beam rotation, new technology and physical processes for beam collimation. The dynamics of the HL-LHC beams will be also particularly challenging and this aspect is the main focus of this paper.

  16. High Luminosity LHC: Challenges and plans

    DOE PAGES

    Arduini, G.; Barranco, J.; Bertarelli, A.; ...

    2016-12-28

    The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up a new energy frontier for exploration in 2010, it has gathered a global user community working in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. To sustain and extend its discovery potential, the LHC will undergo a major upgrade in the 2020s. This will increase its rate of collisions by a factor of five beyond the original design value and the integrated luminosity by a factor ten. The new configuration, known as High Luminosity LHC (HL-LHC), willmore » rely on a number of key innovations that push accelerator technology beyond its present limits. Among these are cutting-edge 11–12 T superconducting magnets, including Nb3Sn-based magnets never used in accelerators before, compact superconducting cavities for longitudinal beam rotation, new technology and physical processes for beam collimation. As a result, the dynamics of the HL-LHC beams will be also particularly challenging and this aspect is the main focus of this paper.« less

  17. High Luminosity LHC: Challenges and plans

    SciTech Connect

    Arduini, G.; Barranco, J.; Bertarelli, A.; Biancacci, N.; Bruce, R.; Bruning, O.; Buffat, X.; Cai, Y.; Carver, L. R.; Fartoukh, S.; Giovannozzi, Massimo; Iadarola, G.; Li, K.; Lechner, A.; Medrano, L. Medina; Metral, E.; Nosochkov, Y.; Papaphilippou, Y.; Pellegrini, D.; Pieloni, T.; Qiang, J.; Redaelli, S.; Romano, A.; Rossi, L.; Rumolo, G.; Salvant, B.; Schenk, M.; Tambasco, C.; Tomas, R.; Valishev, S.; Van der Veken, F. F.

    2016-12-28

    The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up a new energy frontier for exploration in 2010, it has gathered a global user community working in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. To sustain and extend its discovery potential, the LHC will undergo a major upgrade in the 2020s. This will increase its rate of collisions by a factor of five beyond the original design value and the integrated luminosity by a factor ten. The new configuration, known as High Luminosity LHC (HL-LHC), will rely on a number of key innovations that push accelerator technology beyond its present limits. Among these are cutting-edge 11–12 T superconducting magnets, including Nb3Sn-based magnets never used in accelerators before, compact superconducting cavities for longitudinal beam rotation, new technology and physical processes for beam collimation. As a result, the dynamics of the HL-LHC beams will be also particularly challenging and this aspect is the main focus of this paper.

  18. Constraints on gauge-Higgs unification models at the LHC

    NASA Astrophysics Data System (ADS)

    Kitazawa, Noriaki; Sakai, Yuki

    2016-02-01

    We examine the possibility of observing the Kaluza-Klein (KK) gluons in gauge-Higgs unification models at the LHC with the energy s=14 TeV. We consider a benchmark model with the gauge symmetry SU(3)C×SU(3)W in five-dimensional spacetime, where SU(3)C is the gauge symmetry of the strong interaction and SU(3)W is that for the electroweak interaction and a Higgs doublet field. It is natural in general to introduce SU(3)C gauge symmetry in five-dimensional spacetime as well as SU(3)W gauge symmetry in gauge-Higgs unification (GHU) models. Since the fifth dimension is compactified to S1/Z 2 orbifold, there are KK modes of gluons in low-energy effective theory in four-dimensional spacetime. We investigate the resonance contribution of the first KK gluon to dijet invariant mass distribution at the LHC, and provide signal-to-noise ratios in various cases of KK gluon masses and kinematical cuts. Although the results are given in a specific benchmark model, we discuss their application to general GHU models with KK gluons. GHU models can be verified or constrained through the physics of the strong interaction, though they are proposed to solve the naturalness problem in electroweak symmetry breaking.

  19. Supersymmetry without prejudice at the LHC

    NASA Astrophysics Data System (ADS)

    Conley, John A.; Gainer, James S.; Hewett, JoAnne L.; Le, My Phuong; Rizzo, Thomas G.

    2011-07-01

    The discovery and exploration of Supersymmetry in a model-independent fashion will be a daunting task due to the large number of soft-breaking parameters in the MSSM. In this paper, we explore the capability of the ATLAS detector at the LHC (sqrt{s}=14 TeV, 1 fb-1) to find SUSY within the 19-dimensional pMSSM subspace of the MSSM using their standard transverse missing energy and long-lived particle searches that were essentially designed for mSUGRA. To this end, we employ a set of ˜71k previously generated model points in the 19-dimensional parameter space that satisfy all of the existing experimental and theoretical constraints. Employing ATLAS-generated SM backgrounds and following their approach in each of 11 missing energy analyses as closely as possible, we explore all of these 71k model points for a possible SUSY signal. To test our analysis procedure, we first verify that we faithfully reproduce the published ATLAS results for the signal distributions for their benchmark mSUGRA model points. We then show that, requiring all sparticle masses to lie below 1(3) TeV, almost all (two-thirds) of the pMSSM model points are discovered with a significance S>5 in at least one of these 11 analyses assuming a 50% systematic error on the SM background. If this systematic error can be reduced to only 20% then this parameter space coverage is increased. These results are indicative that the ATLAS SUSY search strategy is robust under a broad class of Supersymmetric models. We then explore in detail the properties of the kinematically accessible model points which remain unobservable by these search analyses in order to ascertain problematic cases which may arise in general SUSY searches.

  20. Supersymmetry Without Prejudice at the LHC

    SciTech Connect

    Conley, John A.; Gainer, James S.; Hewett, JoAnne L.; Le, My Phuong; Rizzo, Thomas G.; /SLAC

    2011-08-19

    The discovery and exploration of Supersymmetry in a model-independent fashion will be a daunting task due to the large number of soft-breaking parameters in the MSSM. In this paper, we explore the capability of the ATLAS detector at the LHC ({radical}s = 14 TeV, 1 fb{sup -1}) to find SUSY within the 19-dimensional pMSSM subspace of the MSSM using their standard transverse missing energy and long-lived particle searches that were essentially designed for mSUGRA. To this end, we employ a set of {approx} 71k previously generated model points in the 19-dimensional parameter space that satisfy all of the existing experimental and theoretical constraints. Employing ATLAS-generated SM backgrounds and following their approach in each of 11 missing energy analyses as closely as possible, we explore all of these 71k model points for a possible SUSY signal. To test our analysis procedure, we first verify that we faithfully reproduce the published ATLAS results for the signal distributions for their benchmark mSUGRA model points. We then show that, requiring all sparticle masses to lie below 1(3) TeV, almost all(two-thirds) of the pMSSM model points are discovered with a significance S > 5 in at least one of these 11 analyses assuming a 50% systematic error on the SM background. If this systematic error can be reduced to only 20% then this parameter space coverage is increased. These results are indicative that the ATLAS SUSY search strategy is robust under a broad class of Supersymmetric models. We then explore in detail the properties of the kinematically accessible model points which remain unobservable by these search analyses in order to ascertain problematic cases which may arise in general SUSY searches.

  1. Parton distribution benchmarking with LHC data

    NASA Astrophysics Data System (ADS)

    Ball, Richard D.; Carrazza, Stefano; Del Debbio, Luigi; Forte, Stefano; Gao, Jun; Hartland, Nathan; Huston, Joey; Nadolsky, Pavel; Rojo, Juan; Stump, Daniel; Thorne, Robert S.; Yuan, C.-P.

    2013-04-01

    We present a detailed comparison of the most recent sets of NNLO PDFs from the ABM, CT, HERAPDF, MSTW and NNPDF collaborations. We compare parton distributions at low and high scales and parton luminosities relevant for LHC phenomenology. We study the PDF dependence of LHC benchmark inclusive cross sections and differential distributions for electroweak boson and jet production in the cases in which the experimental covariance matrix is available. We quantify the agreement between data and theory by computing the χ 2 for each data set with all the various PDFs. PDF comparisons are performed consistently for common values of the strong coupling. We also present a benchmark comparison of jet production at the LHC, comparing the results from various available codes and scale settings. Finally, we discuss the implications of the updated NNLO PDF sets for the combined PDF+ α s uncertainty in the gluon fusion Higgs production cross section.

  2. LHC RF System Time-Domain Simulation

    SciTech Connect

    Mastorides, T.; Rivetta, C.; /SLAC

    2010-09-14

    Non-linear time-domain simulations have been developed for the Positron-Electron Project (PEP-II) and the Large Hadron Collider (LHC). These simulations capture the dynamic behavior of the RF station-beam interaction and are structured to reproduce the technical characteristics of the system (noise contributions, non-linear elements, and more). As such, they provide useful results and insight for the development and design of future LLRF feedback systems. They are also a valuable tool for the study of diverse longitudinal beam dynamics effects such as coupled-bunch impedance driven instabilities and single bunch longitudinal emittance growth. Results from these studies and related measurements from PEP-II and LHC have been presented in multiple places. This report presents an example of the time-domain simulation implementation for the LHC.

  3. Higgs coupling measurements at the LHC

    NASA Astrophysics Data System (ADS)

    Englert, Christoph; Kogler, Roman; Schulz, Holger; Spannowsky, Michael

    2016-07-01

    Due to the absence of tantalising hints for new physics during the LHC's Run 1, the extension of the Higgs sector by dimension-six operators will provide the new phenomenological standard for searches of non-resonant extensions of the Standard Model. Using all dominant and subdominant Higgs production mechanisms at the LHC, we compute the constraints on Higgs physics-relevant dimension-six operators in a global and correlated fit. We show in how far these constraints can be improved by new Higgs channels becoming accessible at higher energy and luminosity, both through inclusive cross sections as well as through highly sensitive differential distributions. This allows us to discuss the sensitivity to new effects in the Higgs sector that can be reached at the LHC if direct hints for physics beyond the SM remain elusive. We discuss the impact of these constraints on well-motivated BSM scenarios.

  4. Melatonin modulates the cadmium-induced expression of MT-2 and MT-1 metallothioneins in three lines of human tumor cells (MCF-7, MDA-MB-231 and HeLa).

    PubMed

    Alonso-Gonzalez, Carolina; Mediavilla, Dolores; Martinez-Campa, Carlos; Gonzalez, Alicia; Cos, Samuel; Sanchez-Barcelo, Emilio J

    2008-10-01

    Cadmium (Cd) is a human carcinogen present in tobacco smoke and contaminated industrial soils. Metallothioneins (MTs) are intracellular proteins involved in protecting against Cd. The toxic effects of Cd can be modified by compounds able to modulate MTs synthesis. Melatonin has oncostatic properties and has also been shown to counteract the toxic effects of Cd. In this study we examine the possible role of melatonin in Cd-induced expression of several MT isoforms (MT-2A, MT-1X, MT-1F and MT-1E) in three human tumor cell lines (MCF-7, MDA-MB-231 and HeLa). We found that, in all cell types, melatonin increases Cd-induced expression of MT-2A, which is considered to protect against Cd toxicity. As regards MT-1 subtypes, which have been related with cell invasiveness and high histological grade tumors, melatonin caused Cd-induced expression in both breast cancer cell lines to decrease. These effects point towards melatonin's possible role as a preventive agent for carcinogenesis dependent on Cd contamination.

  5. STATISTICAL CHALLENGES FOR SEARCHES FOR NEW PHYSICS AT THE LHC.

    SciTech Connect

    CRANMER, K.

    2005-09-12

    Because the emphasis of the LHC is on 5{sigma} discoveries and the LHC environment induces high systematic errors, many of the common statistical procedures used in High Energy Physics are not adequate. I review the basic ingredients of LHC searches, the sources of systematics, and the performance of several methods. Finally, I indicate the methods that seem most promising for the LHC and areas that are in need of further study.

  6. New Physics Undercover at the LHC

    NASA Astrophysics Data System (ADS)

    Lou, Hou Keong

    With the completion of 7 TeV and 8 TeV data taking at the Large Hadron Collider (LHC), the physics community witnessed one of the great triumphs of modern physics: the completion of the Standard Model (SM) as an effective theory. The final missing particle, the Higgs boson, was observed and its mass was measured. However, many theoretical questions remain unanswered. What is the source of electroweak symmetry breaking? What is the nature of dark matter? How does gravity fit into the picture? With no definitive hints of new physics at the LHC, we must consider the possibility that our search strategies need to be expanded. Conventional LHC searches focus on theoretically motivated scenarios, such as the Minimal Supersymmetric Standard Models and Little Higgs Theories. However, it is possible that new physics may be entirely different from what we might expect. In this thesis, we examine a variety of scenarios that lead to new physics undercover at the LHC. First we look at potential new physics hiding in Quantum Chromo-Dynamics backgrounds, which may be uncovered using jet substructure techniques in a data-driven way. Then we turn to new long-lived particles hiding in Higgs decay, which may lead to displaced vertices. Such a signal can be unearthed through a data-driven analysis. Then we turn to new physics with ``semi-visible jets'', which lead to missing momentum aligned with jet momentum. These events are vetoed in traditional searches and we demonstrate ways to uncover these signals. Lastly, we explore performance of future colliders in two case studies: Stops and Higgs Portal searches. We show that a 100 TeV collider will lead to significant improvements over 14 TeV LHC runs. Indeed, new physics may lie undercover at the LHC and future colliders, waiting to be discovered.

  7. Using tevatron magnets for HE-LHC or new ring in LHC tunnel

    SciTech Connect

    Piekarz, Henryk; /Fermilab

    2011-08-01

    Two injector accelerator options for HE-LHC of p{sup +} - p{sup +} collisions at 33 TeV cms energy are briefly outlined. One option is based on the Super-SPS (S-SPS) accelerator in the SPS tunnel, and the other one is based on the LER (Low-Energy-Ring) accelerator in the LHC tunnel. Expectations of performance of the main arc accelerator magnets considered for the construction of the S-SPS and of the LER accelerators are used to tentatively devise some selected properties of these accelerators as potential injectors to HE-LHC.

  8. Theoretical interpretation of new jet results from the LHC

    NASA Astrophysics Data System (ADS)

    Vitev, Ivan

    2011-10-01

    Jets physics in heavy ion reactions is an important new area of active research at Relativistic Heavy Ion Collider and at the Large Hadron Collider that paves the way for novel tests of QCD dynamics in dense nuclear matter. Recently, first results on the quenching of leading particles and jets from the LHC lead-lead run at a center-of-mass energy of 2.76 TeV per nucleon-nucleon pair became available. With this motivation, we present a theoretical analysis of the exciting new experimental findings. We emphasize the accuracy that can be achieved in next-to-leading order perturbative calculations and focus on the suppression the single and double inclusive jet cross sections. We demonstrate how the di-jet asymmetry, recently measured by ATLAS and CMS, can be related to these general results. The case of jets tagged by an electroweak boson is exemplified by the Z0+jet channel. We discuss the constraints that the inclusive Z0 measurements by CMS place on cold nuclear matter effects at the LHC. Finally, we clarify the relation between the suppression of inclusive jets, tagged jets and di-jets and the quenching of inclusive particles on the example of the recent ALICE and CMS hadron attenuation data. We conclude by discussing the insights in the in-medium modification of parton showers that the new LHC data provide and point to future directions and effective theories of QCD that can help improve the accuracy of the tools for jet tomography.

  9. Lessons from LHC elastic and diffractive data

    SciTech Connect

    Martin, A.D.; Khoze, V.A.; Ryskin, M.G.

    2015-04-10

    In the light of LHC data, we discuss the global description of all high-energy elastic and diffractive data, using a one-pomeron model, but including multi-pomeron interactions. The LHC data indicate the need of a k{sub t}(s) behaviour, where k{sub t} is the gluon transverse momentum along the partonic ladder structure which describes the pomeron. We also discuss tensions in the data, as well as the t dependence of the slope of dσ{sub el}/dt in the small t domain.

  10. Bigger, Better, Faster, More at the LHC

    SciTech Connect

    Izaguirre, Eder; Manhart, Michael; Wacker, Jay G.; /SLAC

    2010-08-26

    Multijet plus missing energy searches provide universal coverage for theories that have new colored particles that decay into a dark matter candidate and jets. These signals appear at the LHC further out on the missing energy tail than two-to-two scattering indicates. The simplicity of the searches at the LHC contrasts sharply with the Tevatron where more elaborate searches are necessary to separate signal from background. The searches presented in this article effectively distinguish signal from background for any theory where the LSP is a daughter or granddaughter of the pair-produced colored parent particle without ever having to consider missing energies less than 400 GeV.

  11. R-axion detection at LHC

    SciTech Connect

    Goh, Hock-Seng; Ibe, Masahiro; /SLAC

    2009-06-19

    Supersymmetric models with spontaneously broken approximate R-symmetry contains a light spin 0 particle, the R-axion. The properties of the particle can be a powerful probe of the structure of the new physics. In this paper, we discuss the possibilities of the R-axion detection at the LHC experiments. It is challenge to observe this light particle in the LHC environment. However, for typical values in which the mass of the R-axion is a few hundred MeV, we show that those particles can be detected by searching for displaced vertices from R-axion decay.

  12. Charged-particle multiplicity at LHC energies

    ScienceCinema

    None

    2016-07-12

    The talk presents the measurement of the pseudorapidity density and the multiplicity distribution with ALICE at the achieved LHC energies of 0.9 and 2.36 TeV.An overview about multiplicity measurements prior to LHC is given and the related theoretical concepts are briefly discussed.The analysis procedure is presented and the systematic uncertainties are detailed. The applied acceptance corrections and the treatment of diffraction are discussed.The results are compared with model predictions. The validity of KNO scaling in restricted phase space regions is revisited. 

  13. Power converters for future LHC experiments

    NASA Astrophysics Data System (ADS)

    Alderighi, M.; Citterio, M.; Riva, M.; Latorre, S.; Costabeber, A.; Paccagnella, A.; Sichirollo, F.; Spiazzi, G.; Stellini, M.; Tenti, P.; Cova, P.; Delmonte, N.; Lanza, A.; Bernardoni, M.; Menozzi, R.; Baccaro, S.; Iannuzzo, F.; Sanseverino, A.; Busatto, G.; De Luca, V.; Velardi, F.

    2012-03-01

    The paper describes power switching converters suitable for possible power supply distribution networks for the upgraded detectors at the High Luminosity LHC collider. The proposed topologies have been selected by considering their tolerance to the highly hostile environment where the converters will operate as well as their limited electromagnetic noise emission. The analysis focuses on the description of the power supplies for noble liquid calorimeters, such as the Atlas LAr calorimeters, though several outcomes of this research can be applied to other detectors of the future LHC experiments. Experimental results carried on demonstrators are provided.

  14. LHC II system sensitivity to magnetic fluids

    NASA Astrophysics Data System (ADS)

    Cotae, Vlad; Creanga, Ioan

    2005-03-01

    Experiments have been designed to reveal the influences of ferrofluid treatment and static magnetic field exposure on the photosynthetic system II, where the light harvesting complex (LHC II) controls the ratio chlorophyll a/ chlorophyll b (revealing, indirectly, the photosynthesis rate). Spectrophotometric measurement of chlorophyll content revealed different influences for relatively low ferrofluid concentrations (10-30 μl/l) in comparison to higher concentrations (70-100 μl/l). The overlapped effect of the static magnetic field shaped better the stimulatory ferrofluid action on LHC II system in young poppy plantlets.

  15. Techni-Dilaton Signatures at LHC

    NASA Astrophysics Data System (ADS)

    Matsuzaki, Shinya; Yamawaki, Koichi

    2013-03-01

    We explore LHC discovery signatures of techni-dilaton (TD) arising as a composite pseudo Nambu-Goldstone boson (pNGB), associated with the spontaneous breaking of the approximate scale symmetry in the walking technicolor (WTC). We explicitly evaluate the TD 7 TeV LHC production cross sections times the branching ratios in terms of the TD mass MTD as an input parameter for the region 200 GeV < MTD < 1000 GeV in the typical WTC models. It turns out that the TD signatures are quite different from those of the standard model (SM) Higgs.

  16. Production of hhjj at the LHC.

    PubMed

    Dolan, Matthew J; Englert, Christoph; Greiner, Nicolas; Spannowsky, Michael

    2014-03-14

    Until now, a phenomenologically complete analysis of the hh+2j channel at the LHC has been missing. This is mostly due to the high complexity of the involved one-loop gluon fusion contribution and the fact that a reliable estimate thereof cannot be obtained through simplified calculations in the mt→∞ limit. In this Letter, we report on the LHC's potential to access di-Higgs production in association with two jets in a fully showered hadron-level analysis. Our study includes the finite top and bottom mass dependencies for the gluon fusion contribution.

  17. LHC: The Emptiest Space in the Solar System

    ERIC Educational Resources Information Center

    Cid-Vidal, Xabier; Cid, Ramon

    2011-01-01

    Proton beams have been colliding at 7 TeV in the Large Hadron Collider (LHC) since 30 March 2010, meaning that the LHC research programme is underway. Particle physicists around the world are looking forward to using the data from these collisions, as the LHC is running at an energy three and a half times higher than previously achieved at any…

  18. Upgrade of hadron endcap calorimeters CMS at LHC

    NASA Astrophysics Data System (ADS)

    Bunin, P. D.; Zaroubin, A. V.

    2017-09-01

    We present the survey of the main tasks in upgrading the hadron endcap (HE) calorimeters of the CMS experiment at LHC. The results of the HE upgrade during the LHC Long Shutdown (2013-2014) and plans for upgrade during LHC Extended Year End Technical Stop (December 2016-May 2017) are discussed.

  19. LHC: The Emptiest Space in the Solar System

    ERIC Educational Resources Information Center

    Cid-Vidal, Xabier; Cid, Ramon

    2011-01-01

    Proton beams have been colliding at 7 TeV in the Large Hadron Collider (LHC) since 30 March 2010, meaning that the LHC research programme is underway. Particle physicists around the world are looking forward to using the data from these collisions, as the LHC is running at an energy three and a half times higher than previously achieved at any…

  20. Continuing U.S. Participation in the LHC Accelerator Program

    NASA Astrophysics Data System (ADS)

    Syphers, M. J.

    2006-07-01

    The U.S. LHC Accelerator Research Program (LARP) was established to enable U.S. accelerator specialists to take on active and important roles in the LHC accelerator project during its commissioning and early operations, and to be a major collaborator in future LHC performance upgrades. It is hoped that this follow-on effort to the U.S. contributions to the LHC accelerator project will improve the capabilities of the U.S. accelerator community in accelerator science and technology in order to more effectively use, develop, and preserve unique U.S. resources and capabilities during the LHC era.

  1. RENORM predictions of diffraction at LHC confirmed

    SciTech Connect

    Goulianos, Konstantin

    2015-04-10

    The RENORM model predictions of diffractive, total, and total-inelastic cross sections at the LHC are confirmed by recent measurements. The predictions of several other available models are discussed, highlighting their differences from RENORM, mainly arising from the way rapidity gap formation, low- and high-mass diffraction, unitarization, and hadronization are implemented.

  2. U.S. Involvement in the LHC

    DOE PAGES

    Green, Dan

    2016-12-14

    The demise of the SSC in the U.S. created an upheaval in the U.S. high energy physics (HEP) community. Here, the subsequent redirection of HEP efforts to the CERN Large Hadron Collider (LHC) can perhaps be seen as informing on possible future paths for worldwide collaboration on future HEP megaprojects.

  3. Ground Vibration Measurements at LHC Point 4

    SciTech Connect

    Bertsche, Kirk; Gaddi, Andrea; /CERN

    2012-09-17

    Ground vibration was measured at Large Hadron Collider (LHC) Point 4 during the winter shutdown in February 2012. This report contains the results, including power and coherence spectra. We plan to collect and analyze vibration data from representative collider halls to inform specifications for future linear colliders, such as ILC and CLIC. We are especially interested in vibration correlations between final focus lens locations.

  4. U.S. Involvement in the LHC

    SciTech Connect

    Green, Dan

    2016-01-01

    The demise of the SSC in the U.S. created an upheaval in the U.S. High energy physics (HEP) community. The subsequent redirection of HEP efforts to the CERN Large Hadron Collider (LHC) can perhaps be seen as informing on possible future paths for worldwide collaboration on future HEP megaprojects

  5. U.S. Involvement in the LHC

    NASA Astrophysics Data System (ADS)

    Green, Dan

    2016-12-01

    The demise of the SSC in the U.S. created an upheaval in the U.S. high energy physics (HEP) community. The subsequent redirection of HEP efforts to the CERN Large Hadron Collider (LHC) can perhaps be seen as informing on possible future paths for worldwide collaboration on future HEP megaprojects.

  6. Top quark physics expectations at the LHC

    SciTech Connect

    ATLAS Collaboration; CMS Collaboration; Gaponenko, Andrei

    2008-09-30

    The top quark will be produced copiously at the LHC. This will make possible detailed physics studies, and also the use of top quark decays for detector calibration. This talk reviews plans and prospects for top physics activities in ATLAS and CMS experiments.

  7. Phenomenology of flavon fields at the LHC

    SciTech Connect

    Tsumura, Koji; Velasco-Sevilla, Liliana

    2010-02-01

    We study low energy constraints from flavor violating processes, production, and decay at the LHC of a scalar field {phi} (flavon) associated to the breaking of a nonsupersymmetric Abelian family symmetry at the TeV scale. This symmetry is constrained to reproduce fermion masses and mixing, up to O(1) coefficients. The nonsupersymmetric gauged U(1) models considered are severely restricted by cancellation of anomalies and LEP bounds on contact interactions; consequently its phenomenology is out of the LHC reach. We therefore introduce an effective U(1) which is not gauged and is broken explicitly by a CP-odd term at the TeV scale. This helps us to explore flavor violating processes, production, and decay at the LHC for these kind of light scalars. In this context we first study the constraints on the flavon mass and its vacuum expectation value from low energy flavor changing processes such as {mu}{yields}e{gamma}. We find that a flavon of about m{sub {phi}}< or approx. 150 GeV could be experimentally allowed. These kinds of flavons could be significantly generated at the LHC via the gluon fusion mechanism and the single top production channel gu{yields}t{phi}. The produced flavons can have characteristic decay modes such as tc for m{sub {phi}}> or approx. m{sub t}, and {tau}{mu} for m{sub {phi}}< or approx. m{sub t}, which could be effectively useful to detect flavons.

  8. The LHCb Detector at the LHC

    NASA Astrophysics Data System (ADS)

    LHCb Collaboration; Alves, A. Augusto, Jr.; Filho, L. M. Andrade; Barbosa, A. F.; Bediaga, I.; Cernicchiaro, G.; Guerrer, G.; Lima, H. P., Jr.; Machado, A. A.; Magnin, J.; Marujo, F.; de Miranda, J. M.; Reis, A.; Santos, A.; Toledo, A.; Akiba, K.; Amato, S.; de Paula, B.; de Paula, L.; da Silva, T.; Gandelman, M.; Lopes, J. H.; Maréchal, B.; Moraes, D.; Polycarpo, E.; Rodrigues, F.; Ballansat, J.; Bastian, Y.; Boget, D.; DeBonis, I.; Coco, V.; David, P. Y.; Decamp, D.; Delebecque, P.; Drancourt, C.; Dumont-Dayot, N.; Girard, C.; Lieunard, B.; Minard, M. N.; Pietrzyk, B.; Rambure, T.; Rospabe, G.; T'Jampens, S.; Ajaltouni, Z.; Bohner, G.; Bonnefoy, R.; Borras, D.; Carloganu, C.; Chanal, H.; Conte, E.; Cornat, R.; Crouau, M.; Delage, E.; Deschamps, O.; Henrard, P.; Jacquet, P.; Lacan, C.; Laubser, J.; Lecoq, J.; Lefèvre, R.; Magne, M.; Martemiyanov, M.; Mercier, M.-L.; Monteil, S.; Niess, V.; Perret, P.; Reinmuth, G.; Robert, A.; Suchorski, S.; Arnaud, K.; Aslanides, E.; Babel, J.; Benchouk, C.; Cachemiche, J.-P.; Cogan, J.; Derue, F.; Dinkespiler, B.; Duval, P.-Y.; Garonne, V.; Favard, S.; LeGac, R.; Leon, F.; Leroy, O.; Liotard, P.-L.; Marin, F.; Menouni, M.; Ollive, P.; Poss, S.; Roche, A.; Sapunov, M.; Tocco, L.; Viaud, B.; Tsaregorodtsev, A.; Amhis, Y.; Barrand, G.; Barsuk, S.; Beigbeder, C.; Beneyton, R.; Breton, D.; Callot, O.; Charlet, D.; D'Almagne, B.; Duarte, O.; Fulda-Quenzer, F.; Jacholkowska, A.; Jean-Marie, B.; Lefrancois, J.; Machefert, F.; Robbe, P.; Schune, M.-H.; Tocut, V.; Videau, I.; Benayoun, M.; David, P.; DelBuono, L.; Gilles, G.; Domke, M.; Futterschneider, H.; Ilgner, Ch; Kapusta, P.; Kolander, M.; Krause, R.; Lieng, M.; Nedos, M.; Rudloff, K.; Schleich, S.; Schwierz, R.; Spaan, B.; Wacker, K.; Warda, K.; Agari, M.; Bauer, C.; Baumeister, D.; Bulian, N.; Fuchs, H. P.; Fallot-Burghardt, W.; Glebe, T.; Hofmann, W.; Knöpfle, K. T.; Löchner, S.; Ludwig, A.; Maciuc, F.; Sanchez Nieto, F.; Schmelling, M.; Schwingenheuer, B.; Sexauer, E.; Smale, N. J.; Trunk, U.; Voss, H.; Albrecht, J.; Bachmann, S.; Blouw, J.; Deissenroth, M.; Deppe, H.; Dreis, H. B.; Eisele, F.; Haas, T.; Hansmann-Menzemer, S.; Hennenberger, S.; Knopf, J.; Moch, M.; Perieanu, A.; Rabenecker, S.; Rausch, A.; Rummel, C.; Rusnyak, R.; Schiller, M.; Stange, U.; Uwer, U.; Walter, M.; Ziegler, R.; Avoni, G.; Balbi, G.; Bonifazi, F.; Bortolotti, D.; Carbone, A.; D'Antone, I.; Galli, D.; Gregori, D.; Lax, I.; Marconi, U.; Peco, G.; Vagnoni, V.; Valenti, G.; Vecchi, S.; Bonivento, W.; Cardini, A.; Cadeddu, S.; DeLeo, V.; Deplano, C.; Furcas, S.; Lai, A.; Oldeman, R.; Raspino, D.; Saitta, B.; Serra, N.; Baldini, W.; Brusa, S.; Chiozzi, S.; Cotta Ramusino, A.; Evangelisti, F.; Franconieri, A.; Germani, S.; Gianoli, A.; Guoming, L.; Landi, L.; Malaguti, R.; Padoan, C.; Pennini, C.; Savriè, M.; Squerzanti, S.; Zhao, T.; Zhu, M.; Bizzeti, A.; Graziani, G.; Lenti, M.; Lenzi, M.; Maletta, F.; Pennazzi, S.; Passaleva, G.; Veltri, M.; Alfonsi, M.; Anelli, M.; Balla, A.; Battisti, A.; Bencivenni, G.; Campana, P.; Carletti, M.; Ciambrone, P.; Corradi, G.; Dané, E.; Di Virgilio, A.; DeSimone, P.; Felici, G.; Forti, C.; Gatta, M.; Lanfranchi, G.; Murtas, F.; Pistilli, M.; Poli Lener, M.; Rosellini, R.; Santoni, M.; Saputi, A.; Sarti, A.; Sciubba, A.; Zossi, A.; Ameri, M.; Cuneo, S.; Fontanelli, F.; Gracco, V.; Miní, G.; Parodi, M.; Petrolini, A.; Sannino, M.; Vinci, A.; Alemi, M.; Arnaboldi, C.; Bellunato, T.; Calvi, M.; Chignoli, F.; DeLucia, A.; Galotta, G.; Mazza, R.; Matteuzzi, C.; Musy, M.; Negri, P.; Perego, D.; Pessina, G.; Auriemma, G.; Bocci, V.; Buccheri, A.; Chiodi, G.; Di Marco, S.; Iacoangeli, F.; Martellotti, G.; Nobrega, R.; Pelosi, A.; Penso, G.; Pinci, D.; Rinaldi, W.; Rossi, A.; Santacesaria, R.; Satriano, C.; Carboni, G.; Iannilli, M.; Massafferri Rodrigues, A.; Messi, R.; Paoluzzi, G.; Sabatino, G.; Santovetti, E.; Satta, A.; Amoraal, J.; van Apeldoorn, G.; Arink, R.; van Bakel, N.; Band, H.; Bauer, Th; Berkien, A.; van Beuzekom, M.; Bos, E.; Bron, Ch; Ceelie, L.; Doets, M.; van der Eijk, R.; Fransen, J.-P.; de Groen, P.; Gromov, V.; Hierck, R.; Homma, J.; Hommels, B.; Hoogland, W.; Jans, E.; Jansen, F.; Jansen, L.; Jaspers, M.; Kaan, B.; Koene, B.; Koopstra, J.; Kroes, F.; Kraan, M.; Langedijk, J.; Merk, M.; Mos, S.; Munneke, B.; Palacios, J.; Papadelis, A.; Pellegrino, A.; van Petten, O.; du Pree, T.; Roeland, E.; Ruckstuhl, W.; Schimmel, A.; Schuijlenburg, H.; Sluijk, T.; Spelt, J.; Stolte, J.; Terrier, H.; Tuning, N.; Van Lysebetten, A.; Vankov, P.; Verkooijen, J.; Verlaat, B.; Vink, W.; de Vries, H.; Wiggers, L.; Ybeles Smit, G.; Zaitsev, N.; Zupan, M.; Zwart, A.; van den Brand, J.; Bulten, H. J.; de Jong, M.; Ketel, T.; Klous, S.; Kos, J.; M'charek, B.; Mul, F.; Raven, G.; Simioni, E.; Cheng, J.; Dai, G.; Deng, Z.; Gao, Y.; Gong, G.; Gong, H.; He, J.; Hou, L.; Li, J.; Qian, W.; Shao, B.; Xue, T.; Yang, Z.; Zeng, M.; Muryn, B.; Ciba, K.; Oblakowska-Mucha, A.; Blocki, J.; Galuszka, K.; Hajduk, L.; Michalowski, J.; Natkaniec, Z.; Polok, G.; Stodulski, M.; Witek, M.; Brzozowski, K.; Chlopik, A.; Gawor, P.; Guzik, Z.; Nawrot, A.; Srednicki, A.; Syryczynski, K.; Szczekowski, M.; Anghel, D. V.; Cimpean, A.; Coca, C.; Constantin, F.; Cristian, P.; Dumitru, D. D.; Dumitru, D. T.; Giolu, G.; Kusko, C.; Magureanu, C.; Mihon, Gh; Orlandea, M.; Pavel, C.; Petrescu, R.; Popescu, S.; Preda, T.; Rosca, A.; Rusu, V. L.; Stoica, R.; Stoica, S.; Tarta, P. D.; Filippov, S.; Gavrilov, Yu; Golyshkin, L.; Gushchin, E.; Karavichev, O.; Klubakov, V.; Kravchuk, L.; Kutuzov, V.; Laptev, S.; Popov, S.; Aref'ev, A.; Bobchenko, B.; Dolgoshein, V.; Egorychev, V.; Golutvin, A.; Gushchin, O.; Konoplyannikov, A.; Korolko, I.; Kvaratskheliya, T.; Machikhiliyan, I.; Malyshev, S.; Mayatskaya, E.; Prokudin, M.; Rusinov, D.; Rusinov, V.; Shatalov, P.; Shchutska, L.; Tarkovskiy, E.; Tayduganov, A.; Voronchev, K.; Zhiryakova, O.; Bobrov, A.; Bondar, A.; Eidelman, S.; Kozlinsky, A.; Shekhtman, L.; Beloous, K. S.; Dzhelyadin, R. I.; Gelitsky, Yu V.; Gouz, Yu P.; Kachnov, K. G.; Kobelev, A. S.; Matveev, V. D.; Novikov, V. P.; Obraztsov, V. F.; Ostankov, A. P.; Romanovsky, V. I.; Rykalin, V. I.; Soldatov, A. P.; Soldatov, M. M.; Tchernov, E. N.; Yushchenko, O. P.; Bochin, B.; Bondar, N.; Fedorov, O.; Golovtsov, V.; Guets, S.; Kashchuk, A.; Lazarev, V.; Maev, O.; Neustroev, P.; Sagidova, N.; Spiridenkov, E.; Volkov, S.; Vorobyev, An; Vorobyov, A.; Aguilo, E.; Bota, S.; Calvo, M.; Comerma, A.; Cano, X.; Dieguez, A.; Herms, A.; Lopez, E.; Luengo, S.; Garra, J.; Garrido, Ll; Gascon, D.; Gaspar de Valenzuela, A.; Gonzalez, C.; Graciani, R.; Grauges, E.; Perez Calero, A.; Picatoste, E.; Riera, J.; Rosello, M.; Ruiz, H.; Vilasis, X.; Xirgu, X.; Adeva, B.; Cid Vidal, X.; MartÉnez Santos, D.; Esperante Pereira, D.; Fungueiriño Pazos, J. L.; Gallas Torreira, A.; Gómez, C. Lois; Pazos Alvarez, A.; Pérez Trigo, E.; Pló Casasús, M.; Rodriguez Cobo, C.; Rodríguez Pérez, P.; Saborido, J. J.; Seco, M.; Vazquez Regueiro, P.; Bartalini, P.; Bay, A.; Bettler, M.-O.; Blanc, F.; Borel, J.; Carron, B.; Currat, C.; Conti, G.; Dormond, O.; Ermoline, Y.; Fauland, P.; Fernandez, L.; Frei, R.; Gagliardi, G.; Gueissaz, N.; Haefeli, G.; Hicheur, A.; Jacoby, C.; Jalocha, P.; Jimenez-Otero, S.; Hertig, J.-P.; Knecht, M.; Legger, F.; Locatelli, L.; Moser, J.-R.; Needham, M.; Nicolas, L.; Perrin-Giacomin, A.; Perroud, J.-P.; Potterat, C.; Ronga, F.; Schneider, O.; Schietinger, T.; Steele, D.; Studer, L.; Tareb, M.; Tran, M. T.; van Hunen, J.; Vervink, K.; Villa, S.; Zwahlen, N.; Bernet, R.; Büchler, A.; Gassner, J.; Lehner, F.; Sakhelashvili, T.; Salzmann, C.; Sievers, P.; Steiner, S.; Steinkamp, O.; Straumann, U.; van Tilburg, J.; Vollhardt, A.; Volyanskyy, D.; Ziegler, M.; Dovbnya, A.; Ranyuk, Yu; Shapoval, I.; Borisova, M.; Iakovenko, V.; Kyva, V.; Kovalchuk, O.; Okhrimenko, O.; Pugatch, V.; Pylypchenko, Yu; Adinolfi, M.; Brook, N. H.; Head, R. D.; Imong, J. P.; Lessnoff, K. A.; Metlica, F. C. D.; Muir, A. J.; Rademacker, J. H.; Solomin, A.; Szczypka, P. M.; Barham, C.; Buszello, C.; Dickens, J.; Gibson, V.; Haines, S.; Harrison, K.; Jones, C. R.; Katvars, S.; Kerzel, U.; Lazzeroni, C.; Li, Y. Y.; Rogers, G.; Storey, J.; Skottowe, H.; Wotton, S. A.; Adye, T. J.; Densham, C. J.; Easo, S.; Franek, B.; Loveridge, P.; Morrow, D.; Morris, J. V.; Nandakumar, R.; Nardulli, J.; Papanestis, A.; Patrick, G. N.; Ricciardi, S.; Woodward, M. L.; Zhang, Z.; Chamonal, R. J. U.; Clark, P. J.; Clarke, P.; Eisenhardt, S.; Gilardi, N.; Khan, A.; Kim, Y. M.; Lambert, R.; Lawrence, J.; Main, A.; McCarron, J.; Mclean, C.; Muheim, F.; Osorio-Oliveros, A. F.; Playfer, S.; Styles, N.; Xie, Y.; Bates, A.; Carson, L.; da Cunha Marinho, F.; Doherty, F.; Eklund, L.; Gersabeck, M.; Haddad, L.; Macgregor, A. A.; Melone, J.; McEwan, F.; Petrie, D. M.; Paterson, S. K.; Parkes, C.; Pickford, A.; Rakotomiaramanana, B.; Rodrigues, E.; Saavedra, A. F.; Soler, F. J. P.; Szumlak, T.; Viret, S.; Allebone, L.; Awunor, O.; Back, J.; Barber, G.; Barnes, C.; Cameron, B.; Clark, D.; Clark, I.; Dornan, P.; Duane, A.; Eames, C.; Egede, U.; Girone, M.; Greenwood, S.; Hallam, R.; Hare, R.; Howard, A.; Jolly, S.; Kasey, V.; Khaleeq, M.; Koppenburg, P.; Miller, D.; Plackett, R.; Price, D.; Reece, W.; Savage, P.; Savidge, T.; Simmons, B.; Vidal-Sitjes, G.; Websdale, D.; Affolder, A.; Anderson, J. S.; Biagi, S. F.; Bowcock, T. J. V.; Carroll, J. L.; Casse, G.; Cooke, P.; Donleavy, S.; Dwyer, L.; Hennessy, K.; Huse, T.; Hutchcroft, D.; Jones, D.; Lockwood, M.; McCubbin, M.; McNulty, R.; Muskett, D.; Noor, A.; Patel, G. D.; Rinnert, K.; Shears, T.; Smith, N. A.; Southern, G.; Stavitski, I.; Sutcliffe, P.; Tobin, M.; Traynor, S. M.; Turner, P.; Whitley, M.; Wormald, M.; Wright, V.; Bibby, J. H.; Brisbane, S.; Brock, M.; Charles, M.; Cioffi, C.; Gligorov, V. V.; Handford, T.; Harnew, N.; Harris, F.; John, M. J. J.; Jones, M.; Libby, J.; Martin, L.; McArthur, I. A.; Muresan, R.; Newby, C.; Ottewell, B.; Powell, A.; Rotolo, N.; Senanayake, R. S.; Somerville, L.; Soroko, A.; Spradlin, P.; Sullivan, P.; Stokes-Rees, I.; Topp-Jorgensen, S.; Xing, F.; Wilkinson, G.; Artuso, M.; Belyaev, I.; Blusk, S.; Lefeuvre, G.; Menaa, N.; Menaa-Sia, R.; Mountain, R.; Skwarnicki, T.; Stone, S.; Wang, J. C.; Abadie, L.; Aglieri-Rinella, G.; Albrecht, E.; André, J.; Anelli, G.; Arnaud, N.; Augustinus, A.; Bal, F.; Barandela Pazos, M. C.; Barczyk, A.; Bargiotti, M.; Batista Lopes, J.; Behrendt, O.; Berni, S.; Binko, P.; Bobillier, V.; Braem, A.; Brarda, L.; Buytaert, J.; Camilleri, L.; Cambpell, M.; Castellani, G.; Cataneo, F.; Cattaneo, M.; Chadaj, B.; Charpentier, P.; Cherukuwada, S.; Chesi, E.; Christiansen, J.; Chytracek, R.; Clemencic, M.; Closier, J.; Collins, P.; Colrain, P.; Cooke, O.; Corajod, B.; Corti, G.; D'Ambrosio, C.; Damodaran, B.; David, C.; de Capua, S.; Decreuse, G.; Degaudenzi, H.; Dijkstra, H.; Droulez, J.-P.; Duarte Ramos, D.; Dufey, J. P.; Dumps, R.; Eckstein, D.; Ferro-Luzzi, M.; Fiedler, F.; Filthaut, F.; Flegel, W.; Forty, R.; Fournier, C.; Frank, M.; Frei, C.; Gaidioz, B.; Gaspar, C.; Gayde, J.-C.; Gavillet, P.; Go, A.; Gracia Abril, G.; Graulich, J.-S.; Giudici, P.-A.; Guirao Elias, A.; Guglielmini, P.; Gys, T.; Hahn, F.; Haider, S.; Harvey, J.; Hay, B.; Hernando Morata, J.-A.; Herranz Alvarez, J.; van Herwijnen, E.; Hilke, H. J.; von Holtey, G.; Hulsbergen, W.; Jacobsson, R.; Jamet, O.; Joram, C.; Jost, B.; Kanaya, N.; Knaster Refolio, J.; Koestner, S.; Koratzinos, M.; Kristic, R.; Lacarrère, D.; Lasseur, C.; Lastovicka, T.; Laub, M.; Liko, D.; Lippmann, C.; Lindner, R.; Losasso, M.; Maier, A.; Mair, K.; Maley, P.; Mato Vila, P.; Moine, G.; Morant, J.; Moritz, M.; Moscicki, J.; Muecke, M.; Mueller, H.; Nakada, T.; Neufeld, N.; Ocariz, J.; Padilla Aranda, C.; Parzefall, U.; Patel, M.; Pepe-Altarelli, M.; Piedigrossi, D.; Pivk, M.; Pokorski, W.; Ponce, S.; Ranjard, F.; Riegler, W.; Renaud, J.; Roiser, S.; Rossi, A.; Roy, L.; Ruf, T.; Ruffinoni, D.; Saladino, S.; Sambade Varela, A.; Santinelli, R.; Schmelling, S.; Schmidt, B.; Schneider, T.; Schöning, A.; Schopper, A.; Seguinot, J.; Snoeys, W.; Smith, A.; Smith, A. C.; Somogyi, P.; Stoica, R.; Tejessy, W.; Teubert, F.; Thomas, E.; Toledo Alarcon, J.; Ullaland, O.; Valassi, A.; Vannerem, P.; Veness, R.; Wicht, P.; Wiedner, D.; Witzeling, W.; Wright, A.; Wyllie, K.; Ypsilantis, T.

    2008-08-01

    The LHCb experiment is dedicated to precision measurements of CP violation and rare decays of B hadrons at the Large Hadron Collider (LHC) at CERN (Geneva). The initial configuration and expected performance of the detector and associated systems, as established by test beam measurements and simulation studies, is described.

  9. Discovering walking technirho mesons at the LHC

    NASA Astrophysics Data System (ADS)

    Kurachi, Masafumi; Matsuzaki, Shinya; Yamawaki, Koichi

    2014-09-01

    We formulate a scale-invariant hidden local symmetry (HLS) as a low-energy effective theory of walking technicolor (WTC) which includes the technidilaton, technipions, and technirho mesons as the low-lying spectra. As a benchmark for LHC phenomenology, we in particular focus on the one-family model of WTC having eight technifermion flavors, which can be—at energy scales relevant to the reach of the LHC—described by the scale-invariant HLS based on the manifold [SU(8)L×SU(8)R]global×SU(8)local/SU(8)V, where SU(8)local is the HLS and the global SU(8)L×SU(8)R symmetry is partially gauged by the SU(3)×SU(2)L×U(1)Y of the standard model. Based on the scale-invariant HLS, we evaluate the coupling properties of the technirho mesons and place limits on the masses from the current LHC data. Then, implications for future LHC phenomenology are discussed by focusing on the technirho mesons produced through the Drell-Yan process. We find that the color-octet technirho decaying to the technidilaton along with the gluon is of interest as the discovery channel at the LHC, which would provide a characteristic signature to probe the one-family WTC.

  10. Sum-rule constraints on possible diphoton resonances at LHC

    NASA Astrophysics Data System (ADS)

    Roig, P.; Sanz-Cillero, J. J.

    2017-03-01

    The study of the forward scattering amplitude V(k, λ)V(k'λ') → V(k, λ)V(k', λ') of real massless gauge bosons V, e.g. photons or gluons, leads to a sumrule that can be used to investigate beyond the Standard Model signals at LHC in the γγ channel. The sum-rule only relies on general properties such as analyticity, unitarity and crossing. We use the now buried "750 GeV diphoton resonance" as a case of study to exemplify the constraints that the forward sum-rule requires to any new physics candidate. In the case of a large γγ or gg partial width, of the order of 10 GeV in our 750 GeV analysis, one finds that an infinite tower of states with spin JR = 2 and higher must be ultimately incorporated to the beyond Standard Model theory in order to fulfill the sumrule. We expect these techniques may be useful in next diphoton searches at LHC and future colliders.

  11. The complete HEFT Lagrangian after the LHC Run I

    NASA Astrophysics Data System (ADS)

    Brivio, I.; Gonzalez-Fraile, J.; Gonzalez-Garcia, M. C.; Merlo, L.

    2016-07-01

    The complete effective chiral Lagrangian for a dynamical Higgs is presented and constrained by means of a global analysis including electroweak precision data together with Higgs and triple gauge-boson coupling data from the LHC Run I. The operators' basis up to next-to-leading order in the expansion consists of 148 (188 considering right-handed neutrinos) flavour universal terms and it is presented here making explicit the custodial nature of the operators. This effective Lagrangian provides the most general description of the physical Higgs couplings once the electroweak symmetry is assumed, and it allows for deviations from the SU(2)_L doublet nature of the Standard Model Higgs. The comparison with the effective linear Lagrangian constructed with an exact SU(2)_L doublet Higgs and considering operators with at most canonical dimension six is presented. A promising strategy to disentangle the two descriptions consists in analysing (i) anomalous signals present only in the chiral Lagrangian and not expected in the linear one, that are potentially relevant for LHC searches, and (ii) decorrelation effects between observables that are predicted to be correlated in the linear case and not in the chiral one. The global analysis presented here, which includes several kinematic distributions, is crucial for reducing the allowed parameter space and for controlling the correlations between parameters. This improves previous studies aimed at investigating the Higgs Nature and the origin of the electroweak symmetry breaking.

  12. A flippon related singlet at the LHC II

    SciTech Connect

    Li, Tianjun; Maxin, James A.; Mayes, Van E.; Nanopoulos, Dimitri V.

    2016-06-28

    Here, we consider the 750 GeV diphoton resonance at the 13 TeV LHC in the ℱ-SU(5) model with a Standard Model (SM) singlet field which couples to TeV-scale vector-like particles, dubbed flippons. This singlet field assumes the role of the 750 GeV resonance, with production via gluon fusion and subsequent decay to a diphoton via the vector-like particle loops. We present a numerical analysis showing that the observed 8 TeV and 13 TeV diphoton production cross-sections can be generated in the model space with realistic electric charges and Yukawa couplings for light vector-like masses. We further discuss the experimental viability of light vector-like masses in a General No-Scale ℱ-SU(5) model, offering a few benchmark scenarios in this consistent GUT that can satisfy all experimental constraints imposed by the LHC and other essential experiments.

  13. A flippon related singlet at the LHC II

    DOE PAGES

    Li, Tianjun; Maxin, James A.; Mayes, Van E.; ...

    2016-06-28

    Here, we consider the 750 GeV diphoton resonance at the 13 TeV LHC in the ℱ-SU(5) model with a Standard Model (SM) singlet field which couples to TeV-scale vector-like particles, dubbed flippons. This singlet field assumes the role of the 750 GeV resonance, with production via gluon fusion and subsequent decay to a diphoton via the vector-like particle loops. We present a numerical analysis showing that the observed 8 TeV and 13 TeV diphoton production cross-sections can be generated in the model space with realistic electric charges and Yukawa couplings for light vector-like masses. We further discuss the experimental viabilitymore » of light vector-like masses in a General No-Scale ℱ-SU(5) model, offering a few benchmark scenarios in this consistent GUT that can satisfy all experimental constraints imposed by the LHC and other essential experiments.« less

  14. LHAPDF6: parton density access in the LHC precision era

    NASA Astrophysics Data System (ADS)

    Buckley, Andy; Ferrando, James; Lloyd, Stephen; Nordström, Karl; Page, Ben; Rüfenacht, Martin; Schönherr, Marek; Watt, Graeme

    2015-03-01

    The Fortran LHAPDF library has been a long-term workhorse in particle physics, providing standardised access to parton density functions for experimental and phenomenological purposes alike, following on from the venerable PDFLIB package. During Run 1 of the LHC, however, several fundamental limitations in LHAPDF's design have became deeply problematic, restricting the usability of the library for important physics-study procedures and providing dangerous avenues by which to silently obtain incorrect results. In this paper we present the LHAPDF 6 library, a ground-up re-engineering of the PDFLIB/LHAPDF paradigm for PDF access which removes all limits on use of concurrent PDF sets, massively reduces static memory requirements, offers improved CPU performance, and fixes fundamental bugs in multi-set access to PDF metadata. The new design, restricted for now to interpolated PDFs, uses centralised numerical routines and a powerful cascading metadata system to decouple software releases from provision of new PDF data and allow completely general parton content. More than 200 PDF sets have been migrated from LHAPDF 5 to the new universal data format, via a stringent quality control procedure. LHAPDF 6 is supported by many Monte Carlo generators and other physics programs, in some cases via a full set of compatibility routines, and is recommended for the demanding PDF access needs of LHC Run 2 and beyond.

  15. Heavy color-octet particles at the LHC

    SciTech Connect

    Chen, Chien-Yi; Freitas, Ayres; Han, Tao; Lee, Keith S. M.

    2015-05-26

    Many new-physics models, especially those with a color-triplet top-quark partner, contain a heavy color-octet state. The “naturalness” argument for a light Higgs boson requires that the color-octet state be not much heavier than a TeV, and thus it can be pair-produced with large cross sections at high-energy hadron colliders. It may decay preferentially to a top quark plus a top partner, which subsequently decays to a top quark plus a color-singlet state. This singlet can serve as a WIMP dark-matter candidate. Such decay chains lead to a spectacular signal of four top quarks plus missing energy. We pursue a general categorization of the color-octet states and their decay products according to their spin and gauge quantum numbers. Here, we review the current bounds on the new states at the LHC and study the expected discovery reach at the 8-TeV and 14-TeV runs. We also present the production rates at a future 100-TeV hadron collider, where the cross sections will be many orders of magnitude greater than at the 14-TeV LHC. Furthermore, we explore the extent to which one can determine the color octet’s mass, spin, and chiral couplings. Finally, we propose a test to determine whether the fermionic color octet is a Majorana particle.

  16. J. J. Sakurai Prize: Precision Quantum Chromodynamics at the LHC

    NASA Astrophysics Data System (ADS)

    Kosower, David

    2014-03-01

    The Large Hadron Collider (LHC) at CERN in Geneva, Switzerland, is the highest-energy particle collider operating today. In 2012, the two general-purpose detector collaborations, ATLAS and CMS, announced the discovery of the long-sought Higgs boson, the last missing particle of the Standard Model. The two collaborations have also set limits on new physics beyond the Standard Model, such as supersymmetry. Future direct and indirect searches for new physics require a precise, quantitative understanding of the known physics of the Standard Model, and in particular of the scattering of quark and gluon constituents of the proton under the strong force, known today as quantum chromodynamics (QCD). Achieving this level of understanding requires at least the incorporation of the first quantum corrections in perturbation theory - next-to-leading order (NLO) corrections - in scattering processes with several constituents leading to several jets in the final state. The new ``on-shell'' techniques, described earlier by Lance Dixon, have allowed these computations to be made beyond the reach of traditional diagrammatic methods. I will describe a direct numerical application of the new techniques in the BlackHat software library, and several phenomenological studies of physics at the LHC. These include studies relevant to CMS's supersymmetry searches, and to ATLAS measurements of electroweak vector-boson production with up to five associated jets. Partly supported by the European Research Council under Advanced Investigator Grant ERC-AdG-228301.

  17. Flavor changing heavy Higgs interactions at the LHC

    NASA Astrophysics Data System (ADS)

    Altunkaynak, Baris; Hou, Wei-Shu; Kao, Chung; Kohda, Masaya; McCoy, Brent

    2015-12-01

    A general two Higgs doublet model (2HDM) is adopted to study the signature of flavor changing neutral Higgs (FCNH) decay ϕ0 → t c bar + t bar c, where ϕ0 could be a CP-even scalar (H0) or a CP-odd pseudoscalar (A0). Measurement of the light 125 GeV neutral Higgs boson (h0) couplings at the Large Hadron Collider (LHC) favor the decoupling limit or the alignment limit of a 2HDM, in which gauge boson and diagonal fermion couplings of h0 approach Standard Model values. In such limit, FCNH couplings of h0 are naturally suppressed by a small mixing parameter cos ⁡ (β - α), while the off-diagonal couplings of heavier neutral scalars ϕ0 are sustained by sin ⁡ (β - α) ∼ 1. We study physics background from dominant processes with realistic acceptance cuts and tagging efficiencies. Promising results are found for the LHC running at 13 or 14 TeV collision energies.

  18. Flavor changing heavy Higgs interactions at the LHC

    NASA Astrophysics Data System (ADS)

    McCoy, Brent; Altunkaynak, Baris; Kao, Chung; Hou, Wei-Shou; Kohda, Masaya

    2016-03-01

    A general two Higgs doublet model (2HDM) is adopted to study the signature of flavor changing neutral Higgs (FCNH) decay ϕ0 --> t c + t c , where ϕ0 could be a CP-even scalar (H0) or a CP-odd pseudoscalar (A0). Measurement of the light 126 GeV neutral Higgs boson (h0) couplings at the Large Hadron Collider (LHC) favor the decoupling limit or the alignment limit of a 2HDM, in which gauge boson and diagonal fermion couplings of h0 approach Standard Model values. In such a limit, FCNH couplings of h0 are naturally suppressed by a small mixing parameter cos (β - α) , while the off-diagonal couplings of heavier neutral scalars ϕ0 are sustained by sin (β - α) ~ 1 . We study physics background from dominant processes with realistic acceptance cuts and tagging efficiencies. Promising results are found for the LHC running at 13 or 14 TeV collision energies. Academia Sinica, National Taiwan University; OU Supercomputing Center for Education & Research; U.S. Department of Energy, Grant No. DEFG01-13ER41979; Academic Summit Grants: MOST 103-2745-M-002-001-ASP, NTU-EPR-103R8915, and NSC 102-2112-M-033-007-MY3.

  19. The PAX Toolkit and Its Applications at Tevatron and LHC

    NASA Astrophysics Data System (ADS)

    Kappler, S.; Erdmann, M.; Felzmann, U.; Hirschbuhl, D.; Kirsch, M.; Quast, G.; Schmidt, A.; Weng, J.

    2006-04-01

    At the CHEP03 conference we launched the Physics Analysis eXpert (PAX), a C++ toolkit released for the use in advanced high energy physics (HEP) analyses. This toolkit allows to define a level of abstraction beyond detector reconstruction by providing a general, persistent container model for HEP events. Physics objects such as particles, vertices and collisions can easily be stored, accessed and manipulated. Bookkeeping of relations between these objects (like decay trees, vertex and collision separation, etc.) including deep copies is fully provided by the relation management. Event container and associated objects represent a uniform interface for algorithms and facilitate the parallel development and evaluation of different physics interpretations of individual events. So-called analysis factories, which actively identify and distinguish different physics processes and study systematic uncertainties, can easily be realized with the PAX toolkit. PAX is officially released to experiments at Tevatron and LHC. Being explored by a growing user community, it is applied in a number of complex physics analyses, two of which are presented here. We report the successful application in studies of t-tbar production at the Tevatron and Higgs searches in the channel t-tbar-Higgs at the LHC and give a short outlook on further developments.

  20. Production of stoponium at the LHC

    NASA Astrophysics Data System (ADS)

    Kim, Chul; Idilbi, Ahmad; Mehen, Thomas; Yoon, Yeo Woong

    2014-04-01

    Although the Large Hadron Collider (LHC) has not observed supersymmetric (SUSY) partners of the Standard Model particles, their existence is not ruled out yet. One recently explored scenario in which there are light SUSY partners that have evaded current bounds from the LHC is that of a light long-lived stop quark. In this paper we consider light stop pair production at the LHC when the stop mass is between 200 and 400 GeV. If the stops are long-lived they can form a bound state, stoponium, which then undergoes two-body decays to Standard Model particles. By considering the near-threshold production of such a pair through the gluon-gluon fusion process and taking into account the strong Coulombic interactions responsible for the formation of this bound state, we obtain factorization theorems for the stop pair inclusive and differential production cross sections. We also perform a resummation of large threshold logarithms up to next-to-next-to-leading logarithmic accuracy using well-established renormalization group equations in an effective field theory methodology. These results are used to calculate the invariant mass distributions of two photons or two Z bosons coming from the decay of the stoponium at the LHC. For our choices of SUSY model parameters, the stoponium is not detectable above Standard Model backgrounds in γγ or ZZ at 8 TeV, but will be visible with 400 fb-1 of accumulated data if its mass is below 500 GeV when the LHC runs at 14 TeV.

  1. Less-simplified models of dark matter for direct detection and the LHC

    NASA Astrophysics Data System (ADS)

    Choudhury, Arghya; Kowalska, Kamila; Roszkowski, Leszek; Sessolo, Enrico Maria; Williams, Andrew J.

    2016-04-01

    We construct models of dark matter with suppressed spin-independent scattering cross section utilizing the existing simplified model framework. Even simple combinations of simplified models can exhibit interference effects that cause the tree level contribution to the scattering cross section to vanish, thus demonstrating that direct detection limits on simplified models are not robust when embedded in a more complicated and realistic framework. In general for fermionic WIMP masses ≳ 10 GeV direct detection limits on the spin-independent scattering cross section are much stronger than those coming from the LHC. However these model combinations, which we call less-simplified models, represent situations where LHC searches become more competitive than direct detection experiments even for moderate dark matter mass. We show that a complementary use of several searches at the LHC can strongly constrain the direct detection blind spots by setting limits on the coupling constants and mediators' mass. We derive the strongest limits for combinations of vector + scalar, vector + "squark", and "squark" + scalar mediator, and present the corresponding projections for the LHC 14 TeV for a number of searches: mono-jet, jets + missing energy, and searches for heavy vector resonances.

  2. The LHC magnet system and its status of development

    NASA Technical Reports Server (NTRS)

    Bona, Maurizio; Perin, Romeo; Vlogaert, Jos

    1995-01-01

    CERN is preparing for the construction of a new high energy accelerator/collider, the Large Hadron Collider (LHC). This new facility will mainly consist of two superconducting magnetic beam channels, 27 km long, to be installed in the existing LEP tunnel. The magnetic system comprises about 1200 twin-aperture dipoles, 13.145 m long, with an operational field of 8.65 T, about 600 quadrupoles, 3 m long, and a very large number of other superconducting magnetic components. A general description of the system is given together with the main features of the design of the regular lattice magnets. The paper also describes the present state of the magnet R & D program. Results from short model work, as well as from full scale prototypes will be presented, including the recently tested 10 m long full-scale prototype dipole manufactured in industry.

  3. Electroweak Sudakov corrections to new physics searches at the LHC.

    PubMed

    Chiesa, Mauro; Montagna, Guido; Barzè, Luca; Moretti, Mauro; Nicrosini, Oreste; Piccinini, Fulvio; Tramontano, Francesco

    2013-09-20

    We compute the one-loop electroweak Sudakov corrections to the production process Z(νν)+n jets, with n=1, 2, 3, in pp collisions at the LHC. It represents the main irreducible background to new physics searches at the energy frontier. The results are obtained at the leading and next-to-leading logarithmic accuracy by implementing the general algorithm of Denner and Pozzorini in the event generator for multiparton processes alpgen. For the standard selection cuts used by the ATLAS and CMS Collaborations, we show that the Sudakov corrections to the relevant observables can grow up to -40% at sqrt[s ]= 14 TeV. We also include the contribution due to undetected real radiation of massive gauge bosons, to show to what extent the partial cancellation with the large negative virtual corrections takes place in realistic event selections.

  4. Limitation of EFT for DM interactions at the LHC

    NASA Astrophysics Data System (ADS)

    Busoni, G.; de Simone, A.; Gramling, J.; Morgante, E.; Riotto, A.

    We generalize in several directions our recent analysis of the limitations to the use of the effective field theory approach to study dark matter at the LHC. Firstly, we study the full list of operators connecting fermion DM to quarks and gluons, corresponding to integrating out a heavy mediator in the $s$-channel; secondly, we provide analytical results for the validity of the EFT description for both $\\sqrt{s}=8$ {\\rm TeV} and $14$ {\\rm TeV}; thirdly, we make use of a MonteCarlo event generator approach to assess the validity of our analytical conclusions. We apply our results to revisit the current collider bounds on the ultraviolet cut-off scale of the effective field theory and show that these bounds are weakened once the validity conditions of the effective field theory are imposed.

  5. Indirect Searches for Z'-like Resonances at the LHC

    SciTech Connect

    Rizzo, Thomas G.; /SLAC

    2009-06-19

    We explore the possibility of indirectly observing the effects of Z{prime}-like particles with electroweak strength couplings in the Drell-Yan channel at the LHC with masses above the resonance direct search reach. We find that, mostly due to statistical limitations, this is very unlikely in almost all classes of models independently of the spin of the resonance. Not unexpectedly, the one exception to this general result is the case of degenerate Kaluza-Klein (KK) excitations of the photon and Z that occur in some extra-dimensional models. In this special case, the strong destructive interference with the Standard Model (SM) exchanges below the resonance mass leads to a well-known significant suppression of the cross section and thus increased sensitivity to this particular new physics scenario.

  6. Smashing Protons: First Physics at the LHC

    SciTech Connect

    Miller, David

    2010-11-30

    The Large Hadron Collider, at CERN in Geneva, Switzerland, is the largest scientific instrument ever built. For nearly a year now, we have been smashing protons into each other with unprecedented energy, allowing us to peer into nature's most intimate depths. The world's largest and most complex cameras take snapshots of these collisions millions of times per second. These pictures reveal the smallest components of the universe - the quarks and gluons - and, someday, we hope, the elusive Higgs boson. Why do we need to build such an enormous machine in order to study particles more than a million times smaller than a speck of dust? This lecture will explain how the LHC and its detectors work, what the pictures from the LHC are telling us now, and how we will use this technology to explore the deepest secrets of the universe.

  7. Elementary Particle Interactions with CMS at LHC

    SciTech Connect

    Spanier, Stefan

    2016-07-31

    The High Energy Particle Physics group of the University of Tennessee participates in the search for new particles and forces in proton-proton collisions at the LHC with the Compact Muon Solenoid experiment. Since the discovery of the Higgs boson in 2012, the search has intensified to find new generations of particles beyond the standard model using the higher collision energies and ever increasing luminosity, either directly or via deviations from standard model predictions such as the Higgs boson decays. As part of this effort, the UTK group has expanded the search for new particles in four-muon final states, and in final states with jets, has successfully helped and continues to help to implement and operate an instrument for improved measurements of the luminosity needed for all data analyses, and has continued to conduct research of new technologies for charged particle tracking at a high-luminosity LHC.

  8. Novel Geometries for the LHC Crab Cavity

    SciTech Connect

    B. Hall,G. Burt,C. Lingwood,Robert Rimmer,Haipeng Wang; Hall, B.; Burt, G.; Lingwood, C.; Rimmer, Robert; Wang, Haipeng

    2010-05-01

    The planned luminosity upgrade to LHC is likely to necessitate a large crossing angle and a local crab crossing scheme. For this scheme crab cavities align bunches prior to collision. The scheme requires at least four such cavities, a pair on each beam line either side of the interaction point (IP). Upstream cavities initiate rotation and downstream cavities cancel rotation. Cancellation is usually done at a location where the optics has re-aligned the bunch. The beam line separation near the IP necessitates a more compact design than is possible with elliptical cavities such as those used at KEK. The reduction in size must be achieved without an increase in the operational frequency to maintain compatibility with the long bunch length of the LHC. This paper proposes a suitable superconducting variant of a four rod coaxial deflecting cavity (to be phased as a crab cavity), and presents analytical models and simulations of suitable designs.

  9. LHC constraints on gravitino dark matter

    NASA Astrophysics Data System (ADS)

    Arbey, Alexandre; Battaglia, Marco; Covi, Laura; Hasenkamp, Jasper; Mahmoudi, Farvah

    2015-12-01

    Gravitino dark matter (DM) represents a compelling scenario in supersymmetry (SUSY), which brings together a variety of data from cosmology and collider physics. We discuss the constraints obtained from the LHC on supersymmetric models with gravitino dark matter and the neutralino next-to-lightest SUSY particle, which is the case most difficult to disentangle at colliders from a neutralino lightest SUSY particle forming DM. The phenomenological SUSY model with 19 +1 free parameters is adopted. Results are obtained from broad scans of the phase space of these uncorrelated parameters. The relation between gravitino mass, gluino mass and reheating temperature as well as the derived constraints on these parameters are discussed in detail. This relation offers a unique opportunity to place stringent bounds on the cosmological model, within the gravitino dark matter scenario, from the results of the LHC searches in run-2 and the planned high-luminosity upgrade.

  10. LHC Computing: The First Run and Beyond

    SciTech Connect

    Fisk, Ian

    2012-10-10

    Even in between the last two generations of high energy physics detectors there has been a tremendous amount of progress in the area of computing. The distributed computing systems used in the LHC are composed of large-scale facilities on 5 continents, executing over a million processing requests a day, and moving peta-bytes of data a month. In this presentation I will discuss the operational experience of the LHC experiments and the challenges faced in the first run. I will discuss how the techniques have evolved and I will cover future projects to improve the distributed computing infrastructure and services. I will close by speaking of some potential new technologies being explored.

  11. Novel Geometries for the LHC Crab Cavity

    SciTech Connect

    B. Hall, G. Burt, C. Lingwood, R. Rimmer, H. Wang

    2010-05-23

    The planned luminosity upgrade to LHC is likely to necessitate a large crossing angle and a local crab crossing scheme. For this scheme crab cavities align bunches prior to collision. The scheme requires at least four such cavities, a pair on each beam line either side of the interaction point (IP). Upstream cavities initiate rotation and downstream cavities cancel rotation. Cancellation is usually done at a location where the optics has re-aligned the bunch. The beam line separation near the IP necessitates a more compact design than is possible with elliptical cavities such as those used at KEK. The reduction in size must be achieved without an increase in the operational frequency to maintain compatibility with the long bunch length of the LHC. This paper proposes a suitable superconducting variant of a four rod coaxial deflecting cavity (to be phased as a crab cavity), and presents analytical models and simulations of suitable designs.

  12. Jet energy calibration at the LHC

    DOE PAGES

    Schwartzman, Ariel

    2015-11-10

    In this study, jets are one of the most prominent physics signatures of high energy proton–proton (p–p) collisions at the Large Hadron Collider (LHC). They are key physics objects for precision measurements and searches for new phenomena. This review provides an overview of the reconstruction and calibration of jets at the LHC during its first Run. ATLAS and CMS developed different approaches for the reconstruction of jets, but use similar methods for the energy calibration. ATLAS reconstructs jets utilizing input signals from their calorimeters and use charged particle tracks to refine their energy measurement and suppress the effects of multiplemore » p–p interactions (pileup). CMS, instead, combines calorimeter and tracking information to build jets from particle flow objects. Jets are calibrated using Monte Carlo (MC) simulations and a residual in situ calibration derived from collision data is applied to correct for the differences in jet response between data and Monte Carlo.« less

  13. Scalar explanation of diphoton excess at LHC

    NASA Astrophysics Data System (ADS)

    Han, Huayong; Wang, Shaoming; Zheng, Sibo

    2016-06-01

    Inspired by the diphoton signal excess observed in the latest data of 13 TeV LHC, we consider either a 750 GeV real scalar or pseudo-scalar responsible for this anomaly. We propose a concrete vector-like quark model, in which the vector-like fermion pairs directly couple to this scalar via Yukawa interaction. For this setting the scalar is mainly produced via gluon fusion, then decays at the one-loop level to SM diboson channels gg , γγ , ZZ , WW. We show that for the vector-like fermion pairs with exotic electric charges, such model can account for the diphoton excess and is consistent with the data of 8 TeV LHC simultaneously in the context of perturbative analysis.

  14. Jet energy calibration at the LHC

    SciTech Connect

    Schwartzman, Ariel

    2015-11-10

    In this study, jets are one of the most prominent physics signatures of high energy proton–proton (p–p) collisions at the Large Hadron Collider (LHC). They are key physics objects for precision measurements and searches for new phenomena. This review provides an overview of the reconstruction and calibration of jets at the LHC during its first Run. ATLAS and CMS developed different approaches for the reconstruction of jets, but use similar methods for the energy calibration. ATLAS reconstructs jets utilizing input signals from their calorimeters and use charged particle tracks to refine their energy measurement and suppress the effects of multiple p–p interactions (pileup). CMS, instead, combines calorimeter and tracking information to build jets from particle flow objects. Jets are calibrated using Monte Carlo (MC) simulations and a residual in situ calibration derived from collision data is applied to correct for the differences in jet response between data and Monte Carlo.

  15. Null radiation zone at the LHC

    NASA Astrophysics Data System (ADS)

    Hagiwara, Kaoru; Yamada, Toshifumi

    2013-01-01

    The null radiation zone theorem states that, when special kinematical conditions are satisfied, all the helicity amplitudes of a parton-level subprocess where a vector current is emitted vanish due to destructive interference among different diagrams. We study the manifestation of the theorem in pp collisions at the s=8TeV LHC. The theorem predicts that the cross section for pp→jjγ events is suppressed when the transverse momenta of the two jets are similar and when the rapidity difference between the photon and the cluster of the jets is nearly zero, because the uu→uuγ subprocess, which dominates in events with large jjγ invariant mass, has strong destructive interference in this region. We confirm this prediction by the calculation with MadGraph 5, and show that the suppression on the pp→jjγ cross section is observable at the LHC.

  16. Strong Coupling Gauge Theories in LHC ERA

    NASA Astrophysics Data System (ADS)

    Fukaya, H.; Harada, M.; Tanabashi, M.; Yamawaki, K.

    2011-01-01

    AdS/QCD, light-front holography, and the nonperturbative running coupling / Stanley J. Brodsky, Guy de Teramond and Alexandre Deur -- New results on non-abelian vortices - Further insights into monopole, vortex and confinement / K. Konishi -- Study on exotic hadrons at B-factories / Toru Iijima -- Cold compressed baryonic matter with hidden local symmetry and holography / Mannque Rho -- Aspects of baryons in holographic QCD / T. Sakai -- Nuclear force from string theory / K. Hashimoto -- Integrating out holographic QCD back to hidden local symmetry / Masayasu Harada, Shinya Matsuzaki and Koichi Yamawaki -- Holographic heavy quarks and the giant Polyakov loop / Gianluca Grignani, Joanna Karczmarek and Gordon W. Semenoff -- Effect of vector-axial-vector mixing to dilepton spectrum in hot and/or dense matter / Masayasu Harada and Chihiro Sasaki -- Infrared behavior of ghost and gluon propagators compatible with color confinement in Yang-Mills theory with the Gribov horizon / Kei-Ichi Kondo -- Chiral symmetry breaking on the lattice / Hidenori Fukaya [for JLQCD and TWQCD collaborations] -- Gauge-Higgs unification: Stable Higgs bosons as cold dark matter / Yutaka Hosotani -- The limits of custodial symmetry / R. Sekhar Chivukula ... [et al.] -- Higgs searches at the tevatron / Kazuhiro Yamamoto [for the CDF and D[symbol] collaborations] -- The top triangle moose / R. S. Chivukula ... [et al.] -- Conformal phase transition in QCD like theories and beyond / V. A. Miransky -- Gauge-Higgs unification at LHC / Nobuhito Maru and Nobuchika Okada -- W[symbol]W[symbol] scattering in Higgsless models: Identifying better effective theories / Alexander S. Belyaev ... [et al.] -- Holographic estimate of Muon g - 2 / Deog Ki Hong -- Gauge-Higgs dark matter / T. Yamashita -- Topological and curvature effects in a multi-fermion interaction model / T. Inagaki and M. Hayashi -- A model of soft mass generation / J. Hosek -- TeV physics and conformality / Thomas Appelquist -- Conformal

  17. Status of the TOTEM experiment at LHC

    NASA Astrophysics Data System (ADS)

    Baechler, J.; Antchev, G.; Aspell, P.; Atanassov, I.; Avati, V.; Berardi, V.; Berretti, M.; Bossini, E.; Bozzo, M.; Brogi, P.; Brücken, E.; Buzzo, A.; Cafagna, F.; Calicchio, M.; Catanesi, M. G.; Covault, C.; Csörgő, T.; Deile, M.; Eggert, K.; Eremin, V.; Ferretti, R.; Ferro, F.; Fiergolski, A.; Garcia, F.; Giani, S.; Greco, V.; Grzanka, L.; Heino, J.; Hilden, T.; Intonti, M. R.; Kašpar, J.; Kopal, J.; Kundrát, V.; Kurvinen, K.; Lami, S.; Latino, G.; Lauhakangas, R.; Leszko, T.; Lippmaa, E.; Lokajíček, M.; Lo Vetere, M.; Lucas Rodríguez, F.; Macrí, M.; Magaletti, L.; Mercadante, A.; Minafra, N.; Minutoli, S.; Nemes, F.; Niewiadomski, H.; Oliveri, E.; Oljemark, F.; Orava, R.; Oriunno, M.; Österberg, K.; Palazzi, P.; Procházka, J.; Quinto, M.; Radermacher, E.; Radicioni, E.; Ravotti, F.; Robutti, E.; Ropelewski, L.; Ruggiero, G.; Saarikko, H.; Sanguinetti, G.; Santroni, A.; Scribano, A.; Snoeys, W.; Sziklai, J.; Taylor, C.; Turini, N.; Vacek, V.; Vítek, M.; Welti, J.; Whitmore, J.

    2013-08-01

    The TOTEM experiment is dedicated to the measurement of the total proton-proton cross-section with the luminosity-independent method and the study of elastic and diffractive scattering processes. Two tracking telescopes, T1 and T2, integrated in the CMS detector, cover the pseudo-rapidity region between 3.1 and 6.5 on both sides of the interaction point IP5. The Roman Pot (RP) stations are located at distances of ±147 m and ±220 m with respect to the interaction point to measure the very forward scattered protons at very small angles. During the LHC technical stop in winter 2010/2011, the TOTEM experiment was completed with the installation of the T1 telescope and the RP stations at ±147 m. In 2011, the LHC machine provided special optics with the large ß*=90 m, allowing TOTEM to measure the elastic scattering differential cross-section, down to the four-momentum transfer squared |t|=2×10-2 GeV2. Using the optical theorem and extrapolation of the differential cross-section to t=0 (optical point), the total p-p cross-section at the LHC energy of √{ s} = 7 TeV could be computed for the first time. Furthermore we measured with standard LHC beam optics and the energy of √{ s} = 7 TeV the forward charged particle pseudorapidity density dn/dη in the range of 5.3<|η|<6.4. The status of the experiment, the performance of the detectors with emphasis on the RPs are described and the first physics results are presented.

  18. The BRAN luminosity detectors for the LHC

    NASA Astrophysics Data System (ADS)

    Matis, H. S.; Placidi, M.; Ratti, A.; Turner, W. C.; Bravin, E.; Miyamoto, R.

    2017-03-01

    This paper describes the several phases which led, from the conceptual design, prototyping, construction and tests with beam, to the installation and operation of the BRAN (Beam RAte of Neutrals) relative luminosity monitors for the LHC. The detectors have been operating since 2009 to contribute, optimize and maintain the accelerator performance in the two high luminosity interaction regions (IR), the IR1 (ATLAS) and the IR5 (CMS). The devices are gas ionization chambers installed inside a neutral particle absorber 140 m away from the Interaction Points in IR1 and IR5 and monitor the energy deposited by electromagnetic showers produced by high-energy neutral particles from the collisions. The detectors have the capability to resolve the bunch-by-bunch luminosity at the 40 MHz bunch rate, as well as to survive the extreme level of radiation during the nominal LHC operation. The devices have operated since the early commissioning phase of the accelerator over a broad range of luminosities reaching 1.4×1034 cm-2 s-1 with a peak pileup of 45 events per bunch crossing. Even though the nominal design luminosity of the LHC has been exceeded, the BRAN is operating well. After describing how the BRAN can be used to monitor the luminosity of the collider, we discuss the technical choices that led to its construction and the different tests performed prior to the installation in two IRs of the LHC. Performance simulations are presented together with operational results obtained during p-p operations, including runs at 40 MHz bunch rate, Pb-Pb operations and p-Pb operations.

  19. Bottom production asymmetries at the LHC

    SciTech Connect

    Norrbin, E.; Vogt, R.

    1999-01-01

    We present results on bottom hadron production asymmetries at the LHC within both the Lund string fragmentation model and the intrinsic bottom model. The main aspects of the models are summarized and specific predictions for pp collisions at 14 TeV are given. Asymmetries are found to be very small at central rapidities increasing to a few percent at forward rapidities. At very large rapidities intrinsic production could dominate but this region is probably out of reach of any experiment.

  20. Measuring Higgs couplings from LHC data.

    PubMed

    Klute, Markus; Lafaye, Rémi; Plehn, Tilman; Rauch, Michael; Zerwas, Dirk

    2012-09-07

    Following recent ATLAS and CMS publications we interpret the results of their Higgs searches in terms of standard model operators. For a Higgs boson mass of 125 GeV we determine several Higgs couplings from published 2011 data and extrapolate the results towards different scenarios of LHC running. Even though our analysis is limited by low statistics we already derive meaningful constraints on modified Higgs sectors.

  1. Color Sextet Scalars in Early LHC Experiments

    SciTech Connect

    Berger, Edmond L.; Cao Qinghong; Chen, Chuan-Ren; Shaughnessy, Gabe; Zhang Hao

    2010-10-29

    We explore the potential for discovery of an exotic color sextet scalar in same-sign top quark pair production in early running at the LHC. We present the first phenomenological analysis at colliders of color sextet scalars with full top quark spin correlations included. We demonstrate that one can measure the scalar mass, the top quark polarization, and confirm the scalar resonance with 1 fb{sup -1} of integrated luminosity. The top quark polarization can distinguish gauge triplet and singlet scalars.

  2. Foward Calorimetry in ALICE at LHC

    NASA Astrophysics Data System (ADS)

    Chujo, Tatsuya; Alice Focal Collaboration

    2014-09-01

    We present an upgrade proposal for calorimetry in the forward direction, FOCAL, to measure direct photons in η = 3 . 3 - 5 . 3 in ALICE at the Large Hadron Collider (LHC). We suggest to use an electromagnetic calorimeter based on the novel technology of silicon sensors with W absorbers for photons, together with a conventional hadron calorimeter for jet measurements and photon isolation. The current status of the FOCAL R&D project will be presented.

  3. Electron lenses for particle collimation in LHC

    SciTech Connect

    Shiltsev, v.; /Fermilab

    2007-12-01

    Electron Lenses built and installed in Tevatron have proven themselves as safe and very reliable instruments which can be effectively used in hadron collider operation for a number of applications, including compensation of beam-beam effects [1], DC beam removal from abort gaps [2], as a diagnostic tool. In this presentation we - following original proposal [3] - consider in more detail a possibility of using electron lenses with hollow electron beam for ion and proton collimation in LHC.

  4. Dark Matter Jets at the LHC

    SciTech Connect

    Bai, Yang; Rajaraman, Arvind; /UC, Irvine

    2012-03-28

    We argue that dark matter particles which have strong interactions with the Standard Model particles are not excluded by current astrophysical constraints. These dark matter particles have unique signatures at colliders; instead of missing energy, the dark matter particles produce jets. We propose a new search strategy for such strongly interacting particles by looking for a signal of two trackless jets. We show that suitable cuts can plausibly allow us to find these signals at the LHC even in early data.

  5. TOPICAL REVIEW: Soft physics at the LHC

    NASA Astrophysics Data System (ADS)

    Ryskin, M. G.; Martin, A. D.; Khoze, V. A.; Shuvaev, A. G.

    2009-09-01

    We recall the main features of the Regge approach used to understand soft interactions at LHC and higher energies. Unitarity tames the power growth of the elastic proton-proton scattering amplitude with energy and leads to the migration of the secondary particles produced in high-energy proton-proton collisions to larger transverse momenta. We discuss, in qualitative terms, the role of processes containing large rapidity gaps (LRG) and the probability that the gaps survive population by secondaries produced in additional soft interactions. We explain how the Regge diagram corresponding to a LRG event simultaneously describes events with different (single, double, etc) particle density in the same rapidity interval. We show that the role of these, enhanced, multi-Pomeron diagrams can be studied by measuring multiplicity fluctuations and long-range rapidity correlations between secondaries produced at the Tevatron and the LHC. Finally, we make a list of the characteristic features of the multi-Pomeron description of soft interactions that may be observed at the high energies accessible at the Tevatron and the LHC. Based on two lectures by Misha Ryskin at the St. Petersburg Winter School, Gatchina, February 2009.

  6. Processing LHC data in the UK.

    PubMed

    Colling, D; Britton, D; Gordon, J; Lloyd, S; Doyle, A; Gronbech, P; Coles, J; Sansum, A; Patrick, G; Jones, R; Middleton, R; Kelsey, D; Cass, A; Geddes, N; Clark, P; Barnby, L

    2013-01-28

    The Large Hadron Collider (LHC) is one of the greatest scientific endeavours to date. The construction of the collider itself and the experiments that collect data from it represent a huge investment, both financially and in terms of human effort, in our hope to understand the way the Universe works at a deeper level. Yet the volumes of data produced are so large that they cannot be analysed at any single computing centre. Instead, the experiments have all adopted distributed computing models based on the LHC Computing Grid. Without the correct functioning of this grid infrastructure the experiments would not be able to understand the data that they have collected. Within the UK, the Grid infrastructure needed by the experiments is provided by the GridPP project. We report on the operations, performance and contributions made to the experiments by the GridPP project during the years of 2010 and 2011--the first two significant years of the running of the LHC.

  7. Beam Loss Monitoring for LHC Machine Protection

    NASA Astrophysics Data System (ADS)

    Holzer, Eva Barbara; Dehning, Bernd; Effnger, Ewald; Emery, Jonathan; Grishin, Viatcheslav; Hajdu, Csaba; Jackson, Stephen; Kurfuerst, Christoph; Marsili, Aurelien; Misiowiec, Marek; Nagel, Markus; Busto, Eduardo Nebot Del; Nordt, Annika; Roderick, Chris; Sapinski, Mariusz; Zamantzas, Christos

    The energy stored in the nominal LHC beams is two times 362 MJ, 100 times the energy of the Tevatron. As little as 1 mJ/cm3 deposited energy quenches a magnet at 7 TeV and 1 J/cm3 causes magnet damage. The beam dumps are the only places to safely dispose of this beam. One of the key systems for machine protection is the beam loss monitoring (BLM) system. About 3600 ionization chambers are installed at likely or critical loss locations around the LHC ring. The losses are integrated in 12 time intervals ranging from 40 μs to 84 s and compared to threshold values defined in 32 energy ranges. A beam abort is requested when potentially dangerous losses are detected or when any of the numerous internal system validation tests fails. In addition, loss data are used for machine set-up and operational verifications. The collimation system for example uses the loss data for set-up and regular performance verification. Commissioning and operational experience of the BLM are presented: The machine protection functionality of the BLM system has been fully reliable; the LHC availability has not been compromised by false beam aborts.

  8. Processing LHC data in the UK

    PubMed Central

    Colling, D.; Britton, D.; Gordon, J.; Lloyd, S.; Doyle, A.; Gronbech, P.; Coles, J.; Sansum, A.; Patrick, G.; Jones, R.; Middleton, R.; Kelsey, D.; Cass, A.; Geddes, N.; Clark, P.; Barnby, L.

    2013-01-01

    The Large Hadron Collider (LHC) is one of the greatest scientific endeavours to date. The construction of the collider itself and the experiments that collect data from it represent a huge investment, both financially and in terms of human effort, in our hope to understand the way the Universe works at a deeper level. Yet the volumes of data produced are so large that they cannot be analysed at any single computing centre. Instead, the experiments have all adopted distributed computing models based on the LHC Computing Grid. Without the correct functioning of this grid infrastructure the experiments would not be able to understand the data that they have collected. Within the UK, the Grid infrastructure needed by the experiments is provided by the GridPP project. We report on the operations, performance and contributions made to the experiments by the GridPP project during the years of 2010 and 2011—the first two significant years of the running of the LHC. PMID:23230163

  9. Compressed electroweakino spectra at the LHC

    NASA Astrophysics Data System (ADS)

    Schwaller, Pedro; Zurita, José

    2014-03-01

    In this work, we examine the sensitivity of monojet searches at the LHC to directly produced charginos and neutralinos (electroweakinos) in the limit of small mass splitting, where the traditional multilepton plus missing energy searches loose their sensitivity. We first recast the existing 8 TeV monojet search at CMS in terms of a SUSY simplified model with only light gauginos (winos and binos) or only light Higgsinos. The current searches are not sensitive to MSSM-like production cross sections, but would be sensitive to models with 2-20 times enhanced production cross section, for particle masses between 100 GeV and 250 GeV. Then we explore the sensitivity in the 14 TeV run of the LHC. Here we emphasise that in addition to the pure monojet search, soft leptons present in the samples can be used to increase the sensitivity. Exclusion of electroweakino masses up to 200 GeV is possible with 300 fb-1 at the LHC, if the systematic error can be reduced to the 1% level. Discovery is possible with 3000 fb-1 in some regions of parameter space.

  10. LHC signatures of WIMP-triggered baryogenesis

    NASA Astrophysics Data System (ADS)

    Cui, Yanou; Okui, Takemichi; Yunesi, Arash

    2016-12-01

    A robust mechanism was recently proposed in which thermal freeze-out of WIMPs can provide a unified origin of dark matter and baryon abundances in our universe. We point out that this WIMP-triggered baryogenesis mechanism can exhibit a rich collider phenomenology and be tested at the current and near-future experiments at LHC, even in the case where the WIMPs are completely devoid of SM gauge and Higgs portal interactions, as may be motivated by the persistent null results of WIMP dark matter searches. We catalog a rich array of LHC signatures robustly present in such a scenario. In particular, the simplest such implementation can already offer a very clean signal of a TeV-scale resonance that decays to diphotons with a cross section that can easily be within the reach of the current and near-future LHC runs in the region of parameter space that leads to a successful baryogenesis. Other characteristic signatures include the production of multiple bottom and/or multiple top quarks, promptly or displaced. An even more exotic possibility is the production of two separate sets of isolated emerging jets connected by a charged track, which may require new dedicated studies. Finally, dinucleon decay can also provide a powerful probe of the mechanism.

  11. Scalar unparticle signals at the LHC

    NASA Astrophysics Data System (ADS)

    Aliev, T. M.; Bilmiş, S.; Solmaz, M.; Turan, I.

    2017-05-01

    If scale invariance exists in nature, the so-called "unparticle physics" may become part of reality. The only way to refute or confirm this idea is through experiments, such as those at the Large Hadron Collider (LHC). One of the peculiar properties of the unparticle stuff is that it gives striking multiphoton signals which have been studied through only the unparticle self-interactions. By considering not only the self-interactions of unparticles but also all the other possible contributions, which are dominant, a detailed study of the processes, within a scalar unparticle scenario, p p →4 γ , p p →2 γ 2 g , p p →2 γ 2 ℓ, p p →4 e , p p →4 μ and p p →2 e 2 μ at √{s }=14 TeV at the LHC is carried out. We use basic selection cuts and analyze various distributions to discriminate the signals over the Standard Model backgrounds and discuss what seems to be the most likely channel among the above for an indirect manifestation of unparticle effects. We follow a new approach to tackle the issue with the three-point correlation function for the scalar unparticle self-interactions. We also obtain the exclusion region in the unparticle parameter space from the available two-photon data of the LHC and compare it with the existing bounds coming from other sources.

  12. Experiment Dashboard for Monitoring of the LHC Distributed Computing Systems

    NASA Astrophysics Data System (ADS)

    Andreeva, J.; Devesas Campos, M.; Tarragon Cros, J.; Gaidioz, B.; Karavakis, E.; Kokoszkiewicz, L.; Lanciotti, E.; Maier, G.; Ollivier, W.; Nowotka, M.; Rocha, R.; Sadykov, T.; Saiz, P.; Sargsyan, L.; Sidorova, I.; Tuckett, D.

    2011-12-01

    LHC experiments are currently taking collisions data. A distributed computing model chosen by the four main LHC experiments allows physicists to benefit from resources spread all over the world. The distributed model and the scale of LHC computing activities increase the level of complexity of middleware, and also the chances of possible failures or inefficiencies in involved components. In order to ensure the required performance and functionality of the LHC computing system, monitoring the status of the distributed sites and services as well as monitoring LHC computing activities are among the key factors. Over the last years, the Experiment Dashboard team has been working on a number of applications that facilitate the monitoring of different activities: including following up jobs, transfers, and also site and service availabilities. This presentation describes Experiment Dashboard applications used by the LHC experiments and experience gained during the first months of data taking.

  13. High-field Magnet Development toward the High Luminosity LHC

    SciTech Connect

    Apollinari, Giorgio

    2014-07-01

    The upcoming Luminosity upgrade of the LHC (HL-LHC) will rely on the use of Accelerator Quality Nb3Sn Magnets which have been the focus of an intense R&D effort in the last decade. This contribution will describe the R&D and results of Nb3Sn Accelerator Quality High Field Magnets development efforts, with emphasis on the activities considered for the HL-LHC upgrades.

  14. The Large Hadron Collider (LHC): The Energy Frontier

    NASA Astrophysics Data System (ADS)

    Brianti, Giorgio; Jenni, Peter

    The following sections are included: * Introduction * Superconducting Magnets: Powerful, Precise, Plentiful * LHC Cryogenics: Quantum Fluids at Work * Current Leads: High Temperature Superconductors to the Fore * A Pumping Vacuum Chamber: Ultimate Simplicity * Vertex Detectors at LHC: In Search of Beauty * Large Silicon Trackers: Fast, Precise, Efficient * Two Approaches to High Resolution Electromagnetic Calorimetry * Multigap Resistive Plate Chamber: Chronometry of Particles * The LHCb RICH: The Lord of the Cherenkov Rings * Signal Processing: Taming the LHC Data Avalanche * Giant Magnets for Giant Detectors

  15. A fixed-target programme at the LHC (AFTER@LHC)

    NASA Astrophysics Data System (ADS)

    Trzeciak, Barbara; AFTER@LHC study group

    2017-01-01

    We report on the perspectives for hadron, heavy-ion and spin physics with a multi-purpose fixed-target programme using the LHC multi-TeV proton and heavy-ion beams (AFTER@LHC). This would be the most energetic fixed-target experiment opening new domains of particle and nuclear physics and complementing current and future collider programmes. Thanks to the large boost, one can fully access –with conventional detectors– the backward hemisphere in the center-of-mass system which allows for studies of the largely uncharted high-x region (xF → -1).

  16. Progress towards next generation hadron colliders: FCC-hh, HE-LHC, and SPPC

    NASA Astrophysics Data System (ADS)

    Zimmermann, Frank; EuCARD-2 Extreme Beams Collaboration; Future Circular Collider (FCC) Study Collaboration

    2017-01-01

    A higher-energy circular proton collider is generally considered to be the only path available in this century for exploring energy scales well beyond the reach of the Large Hadron Collider (LHC) presently in operation at CERN. In response to the 2013 Update of the European Strategy for Particle Physics and aligned with the 2014 US ``P5'' recommendations, the international Future Circular Collider (FCC) study, hosted by CERN, is designing such future frontier hadron collider. This so-called FCC-hh will provide proton-proton collisions at a centre-of-mass energy of 100 TeV, with unprecedented luminosity. The FCC-hh energy goal is reached by combining higher-field, 16 T magnets, based on Nb3Sn superconductor, and a new 100 km tunnel connected to the LHC complex. In addition to the FCC-hh proper, the FCC study is also exploring the possibility of a High-Energy LHC (HE-LHC), with a centre-of-mass energy of 25-27 TeV, as could be achieved in the existing 27 km LHC tunnel using the FCC-hh magnet technology. A separate design effort centred at IHEP Beijing aims at developing and constructing a similar collider in China, with a smaller circumference of about 54 km, called SPPC. Assuming even higher-field 20 T magnets, by relying on high-temperature superconductor, the SPPC could reach a c.m. energy of about 70 TeV. This presentation will report the motivation and the present status of the R&D for future hadron colliders, a comparison of the three designs under consideration, the major challenges, R&D topics, the international technology programs, and the emerging global collaboration. Work supported by the European Commission under Capacities 7th Framework Programme project EuCARD-2, Grant Agreement 312453, and the HORIZON 2020 project EuroCirCol, Grant Agreement 654305.

  17. Is leptogenesis falsifiable at LHC?

    NASA Astrophysics Data System (ADS)

    Frère, Jean-Marie; Hambye, Thomas; Vertongen, Gilles

    2009-01-01

    It is well known that the leptogenesis mechanism offers an attractive possibility to explain the baryon asymmetry of the universe. Its particular robustness however comes with one major difficulty: it will be very hard if not impossible to test experimentally in a foreseeable future, as most of the mechanics typically takes place at high energy or results from suppressed interactions, without unavoidable low-energy implications. An alternate approach is taken by asking: can it be at least falsified? We show that possible discoveries at current and future colliders, most notably that of right-handed gauge interactions, would indeed forbid at least the "canonical" leptogenesis mechanisms, namely those based on right-handed neutrino decay. General lower bounds for successful leptogenesis on the mass of the right-handed gauge boson WR are given. Other possibilities to falsify leptogenesis, including from the observation of a Z', are also considered.

  18. 3D sensors for the HL-LHC

    NASA Astrophysics Data System (ADS)

    Vázquez Furelos, D.; Carulla, M.; Cavallaro, E.; Förster, F.; Grinstein, S.; Lange, J.; López Paz, I.; Manna, M.; Pellegrini, G.; Quirion, D.; Terzo, S.

    2017-01-01

    In order to increase its discovery potential, the Large Hadron Collider (LHC) accelerator will be upgraded in the next decade. The high luminosity LHC (HL-LHC) period requires new sensor technologies to cope with increasing radiation fluences and particle rates. The ATLAS experiment will replace the entire inner tracking detector with a completely new silicon-only system. 3D pixel sensors are promising candidates for the innermost layers of the Pixel detector due to their excellent radiation hardness at low operation voltages and low power dissipation at moderate temperatures. Recent developments of 3D sensors for the HL-LHC are presented.

  19. Large hadron collider (LHC) project quality assurance plan

    SciTech Connect

    Gullo, Lisa; Karpenko, Victor; Robinson, Kem; Turner, William; Wong, Otis

    2002-09-30

    The LHC Quality Assurance Plan is a set of operating principles, requirements, and practices used to support Berkeley Lab's participation in the Large Hadron Collider Project. The LHC/QAP is intended to achieve reliable, safe, and quality performance in the LHC project activities. The LHC/QAP is also designed to fulfill the following objectives: (1) The LHC/QAP is Berkeley Lab's QA program document that describes the elements necessary to integrate quality assurance, safety management, and conduct of operations into the Berkeley Lab's portion of the LHC operations. (2) The LHC/QAP provides the framework for Berkeley Lab LHC Project administrators, managers, supervisors, and staff to plan, manage, perform, and assess their Laboratory work. (3) The LHC/QAP is the compliance document that conforms to the requirements of the Laboratory's Work Smart Standards for quality assurance (DOE O 414.1, 10 CFR 830.120), facility operations (DOE O 5480.19), and safety management (DOE P 450.4).

  20. The CMSSM and NUHM1 after LHC Run 1.

    PubMed

    Buchmueller, O; Cavanaugh, R; Roeck, A De; Dolan, M J; Ellis, J R; Flächer, H; Heinemeyer, S; Isidori, G; Marrouche, J; Santos, D Martínez; Olive, K A; Rogerson, S; Ronga, F J; de Vries, K J; Weiglein, G

    We analyze the impact of data from the full Run 1 of the LHC at 7 and 8 TeV on the CMSSM with [Formula: see text] and [Formula: see text] and the NUHM1 with [Formula: see text], incorporating the constraints imposed by other experiments such as precision electroweak measurements, flavour measurements, the cosmological density of cold dark matter and the direct search for the scattering of dark matter particles in the LUX experiment. We use the following results from the LHC experiments: ATLAS searches for events with [Formula: see text] accompanied by jets with the full 7 and 8 TeV data, the ATLAS and CMS measurements of the mass of the Higgs boson, the CMS searches for heavy neutral Higgs bosons and a combination of the LHCb and CMS measurements of [Formula: see text] and [Formula: see text]. Our results are based on samplings of the parameter spaces of the CMSSM for both [Formula: see text] and [Formula: see text] and of the NUHM1 for [Formula: see text] with 6.8[Formula: see text], 6.2[Formula: see text] and 1.6[Formula: see text] points, respectively, obtained using the MultiNest tool. The impact of the Higgs-mass constraint is assessed using FeynHiggs 2.10.0, which provides an improved prediction for the masses of the MSSM Higgs bosons in the region of heavy squark masses. It yields in general larger values of [Formula: see text] than previous versions of FeynHiggs, reducing the pressure on the CMSSM and NUHM1. We find that the global [Formula: see text] functions for the supersymmetric models vary slowly over most of the parameter spaces allowed by the Higgs-mass and the [Formula: see text] searches, with best-fit values that are comparable to the [Formula: see text] for the best Standard Model fit. We provide 95 % CL lower limits on the masses of various sparticles and assess the prospects for observing them during Run 2 of the LHC.

  1. The CMSSM and NUHM1 after LHC Run 1

    DOE PAGES

    Buchmueller, O.; De Roeck, A.; Cavanaugh, R.; ...

    2014-06-13

    We analyze the impact of data from the full Run 1 of the LHC at 7 and 8 TeV on the CMSSM with μ > 0 and < 0 and the NUHM1 with μ > 0, incorporating the constraints imposed by other experiments such as precision electroweak measurements, flavour measurements, the cosmological density of cold dark matter and the direct search for the scattering of dark matter particles in the LUX experiment. We use the following results from the LHC experiments: ATLAS searches for events with E/T accompanied by jets with the full 7 and 8 TeV data, the ATLASmore » and CMS measurements of the mass of the Higgs boson, the CMS searches for heavy neutral Higgs bosons and a combination of the LHCb and CMS measurements of BR(Bs → μ+μ–) and BR(Bd → μ+μ–). Our results are based on samplings of the parameter spaces of the CMSSM for both μ > 0 and μ < 0 and of the NUHM1 for μ > 0 with 6.8×106, 6.2×106 and 1.6×107 points, respectively, obtained using the MultiNest tool. The impact of the Higgs-mass constraint is assessed using FeynHiggs 2.10.0, which provides an improved prediction for the masses of the MSSM Higgs bosons in the region of heavy squark masses. It yields in general larger values of Mh than previous versions of FeynHiggs, reducing the pressure on the CMSSM and NUHM1. We find that the global χ2 functions for the supersymmetric models vary slowly over most of the parameter spaces allowed by the Higgs-mass and the E/T searches, with best-fit values that are comparable to the χ2/dof for the best Standard Model fit. As a result, we provide 95% CL lower limits on the masses of various sparticles and assess the prospects for observing them during Run 2 of the LHC.« less

  2. The CMSSM and NUHM1 after LHC Run 1

    SciTech Connect

    Buchmueller, O.; De Roeck, A.; Cavanaugh, R.; Dolan, M. J.; Ellis, J. R.; Flacher, H.; Heinemeyer, S.; Isidori, G.; Marrouche, J.; Martinez Santos, D.; Olive, K. A.; Rogerson, S.; Ronga, F. J.; de Vries, K. J.; Weiglein, G.

    2014-06-13

    We analyze the impact of data from the full Run 1 of the LHC at 7 and 8 TeV on the CMSSM with μ > 0 and < 0 and the NUHM1 with μ > 0, incorporating the constraints imposed by other experiments such as precision electroweak measurements, flavour measurements, the cosmological density of cold dark matter and the direct search for the scattering of dark matter particles in the LUX experiment. We use the following results from the LHC experiments: ATLAS searches for events with E/T accompanied by jets with the full 7 and 8 TeV data, the ATLAS and CMS measurements of the mass of the Higgs boson, the CMS searches for heavy neutral Higgs bosons and a combination of the LHCb and CMS measurements of BR(Bs → μ+μ) and BR(Bd → μ+μ). Our results are based on samplings of the parameter spaces of the CMSSM for both μ > 0 and μ < 0 and of the NUHM1 for μ > 0 with 6.8×106, 6.2×106 and 1.6×107 points, respectively, obtained using the MultiNest tool. The impact of the Higgs-mass constraint is assessed using FeynHiggs 2.10.0, which provides an improved prediction for the masses of the MSSM Higgs bosons in the region of heavy squark masses. It yields in general larger values of Mh than previous versions of FeynHiggs, reducing the pressure on the CMSSM and NUHM1. We find that the global χ2 functions for the supersymmetric models vary slowly over most of the parameter spaces allowed by the Higgs-mass and the E/T searches, with best-fit values that are comparable to the χ2/dof for the best Standard Model fit. As a result, we provide 95% CL lower limits on the masses of various sparticles and assess the prospects for observing them during Run 2 of the LHC.

  3. Supersymmetry Without Prejudice at the 7 TeV LHC

    SciTech Connect

    Conley, John A.; Gainer, James S.; Hewett, JoAnne L.; Le, My Phuong; Rizzo, Thomas G.; /SLAC

    2011-08-12

    We investigate the model independent nature of the Supersymmetry search strategies at the 7 TeV LHC. To this end, we study the missing-transverse-energy-based searches developed by the ATLAS Collaboration that were essentially designed for mSUGRA. We simulate the signals for {approx} 71k models in the 19-dimensional parameter space of the pMSSM. These models have been found to satisfy existing experimental and theoretical constraints and provide insight into general features of the MSSM without reference to a particular SUSY breaking scenario or any other assumptions at the GUT scale. Using backgrounds generated by ATLAS, we find that imprecise knowledge of these estimated backgrounds is a limiting factor in the potential discovery of these models and that some channels become systematics-limited at larger luminosities. As this systematic error is varied between 20-100%, roughly half to 90% of this model sample is observable with significance S {ge} 5 for 1 fb{sup -1} of integrated luminosity. We then examine the model characteristics for the cases which cannot be discovered and find several contributing factors. We find that a blanket statement that squarks and gluinos are excluded with masses below a specific value cannot be made. We next explore possible modifications to the kinematic cuts in these analyses that may improve the pMSSM model coverage. Lastly, we examine the implications of a null search at the 7 TeV LHC in terms of the degree of fine-tuning that would be present in this model set and for sparticle production at the 500 GeV and 1 TeV Linear Collider.

  4. Supersymmetric dark matter after LHC run 1.

    PubMed

    Bagnaschi, E A; Buchmueller, O; Cavanaugh, R; Citron, M; De Roeck, A; Dolan, M J; Ellis, J R; Flächer, H; Heinemeyer, S; Isidori, G; Malik, S; Martínez Santos, D; Olive, K A; Sakurai, K; de Vries, K J; Weiglein, G

    Different mechanisms operate in various regions of the MSSM parameter space to bring the relic density of the lightest neutralino, [Formula: see text], assumed here to be the lightest SUSY particle (LSP) and thus the dark matter (DM) particle, into the range allowed by astrophysics and cosmology. These mechanisms include coannihilation with some nearly degenerate next-to-lightest supersymmetric particle such as the lighter stau [Formula: see text], stop [Formula: see text] or chargino [Formula: see text], resonant annihilation via direct-channel heavy Higgs bosons H / A, the light Higgs boson h or the Z boson, and enhanced annihilation via a larger Higgsino component of the LSP in the focus-point region. These mechanisms typically select lower-dimensional subspaces in MSSM scenarios such as the CMSSM, NUHM1, NUHM2, and pMSSM10. We analyze how future LHC and direct DM searches can complement each other in the exploration of the different DM mechanisms within these scenarios. We find that the [Formula: see text] coannihilation regions of the CMSSM, NUHM1, NUHM2 can largely be explored at the LHC via searches for [Formula: see text] events and long-lived charged particles, whereas their H / A funnel, focus-point and [Formula: see text] coannihilation regions can largely be explored by the LZ and Darwin DM direct detection experiments. We find that the dominant DM mechanism in our pMSSM10 analysis is [Formula: see text] coannihilation: parts of its parameter space can be explored by the LHC, and a larger portion by future direct DM searches.

  5. Astrophysical constraints on singlet scalars at LHC

    NASA Astrophysics Data System (ADS)

    Hertzberg, Mark P.; Masoumi, Ali

    2017-04-01

    We consider the viability of new heavy gauge singlet scalar particles at colliders such as the LHC . Our original motivation for this study came from the possibility of a new heavy particle of mass ~ TeV decaying significantly into two photons at colliders, such as LHC, but our analysis applies more broadly. We show that there are significant constraints from astrophysics and cosmology on the simplest UV complete models that incorporate such new particles and its associated collider signal. The simplest and most obvious UV complete model that incorporates such signals is that it arises from a new singlet scalar (or pseudo-scalar) coupled to a new electrically charged and colored heavy fermion. Here we show that these new fermions (and anti-fermions) would be produced in the early universe, then form new color singlet heavy mesons with light quarks, obtain a non-negligible freeze-out abundance, and remain in kinetic equilibrium until decoupling. These heavy mesons possess interesting phenomenology, dependent on their charge, including forming new bound states with electrons and protons. We show that a significant number of these heavy states would survive for the age of the universe and an appreciable number would eventually be contained within the earth and solar system. We show that this leads to detectable consequences, including the production of highly energetic events from annihilations on earth, new spectral lines, and, spectacularly, the destabilization of stars. The lack of detection of these consequences rules out such simple UV completions, putting pressure on the viability of such new particles at LHC . To incorporate such a scalar would require either much more complicated UV completions or even further new physics that provides a decay channel for the associated fermion.

  6. Supersymmetric Dark Matter after LHC Run 1

    SciTech Connect

    Bagnaschi, E. A.; Buchmueller, O.; Cavanaugh, R.; Citron, M.; De Roeck, A.; Dolan, M. J.; Ellis, J. R.; Flacher, H.; Heinemeyer, S.; Isidori, G.; Malik, S.; Santos, D. Martinez; Olive, K. A.; Sakurai, K.; de Vries, K. J.; Weiglein, G.

    2015-10-23

    Different mechanisms operate in various regions of the MSSM parameter space to bring the relic density of the lightest neutralino, χ~01, assumed here to be the lightest SUSY particle (LSP) and thus the dark matter (DM) particle, into the range allowed by astrophysics and cosmology. These mechanisms include coannihilation with some nearly degenerate next-to-lightest supersymmetric particle such as the lighter stau τ~1, stop t~1 or chargino χ1, resonant annihilation via direct-channel heavy Higgs bosons H / A, the light Higgs boson h or the Z boson, and enhanced annihilation via a larger Higgsino component of the LSP in the focus-point region. These mechanisms typically select lower-dimensional subspaces in MSSM scenarios such as the CMSSM, NUHM1, NUHM2, and pMSSM10. We analyze how future LHC and direct DM searches can complement each other in the exploration of the different DM mechanisms within these scenarios. We find that the τ~1 coannihilation regions of the CMSSM, NUHM1, NUHM2 can largely be explored at the LHC via searches for /ET events and long-lived charged particles, whereas theirH / A funnel, focus-point and χ1 coannihilation regions can largely be explored by the LZ and Darwin DM direct detection experiments. Furthermore, we find that the dominant DM mechanism in our pMSSM10 analysis is χ~±1 coannihilation: parts of its parameter space can be explored by the LHC, and a larger portion by future direct DM searches.

  7. Supersymmetric Dark Matter after LHC Run 1

    DOE PAGES

    Bagnaschi, E. A.; Buchmueller, O.; Cavanaugh, R.; ...

    2015-10-23

    Different mechanisms operate in various regions of the MSSM parameter space to bring the relic density of the lightest neutralino, χ~01, assumed here to be the lightest SUSY particle (LSP) and thus the dark matter (DM) particle, into the range allowed by astrophysics and cosmology. These mechanisms include coannihilation with some nearly degenerate next-to-lightest supersymmetric particle such as the lighter stau τ~1, stop t~1 or chargino χ~±1, resonant annihilation via direct-channel heavy Higgs bosons H / A, the light Higgs boson h or the Z boson, and enhanced annihilation via a larger Higgsino component of the LSP in the focus-pointmore » region. These mechanisms typically select lower-dimensional subspaces in MSSM scenarios such as the CMSSM, NUHM1, NUHM2, and pMSSM10. We analyze how future LHC and direct DM searches can complement each other in the exploration of the different DM mechanisms within these scenarios. We find that the τ~1 coannihilation regions of the CMSSM, NUHM1, NUHM2 can largely be explored at the LHC via searches for /ET events and long-lived charged particles, whereas theirH / A funnel, focus-point and χ~±1 coannihilation regions can largely be explored by the LZ and Darwin DM direct detection experiments. Furthermore, we find that the dominant DM mechanism in our pMSSM10 analysis is χ~±1 coannihilation: parts of its parameter space can be explored by the LHC, and a larger portion by future direct DM searches.« less

  8. Heavy-ion collisions at the LHC

    NASA Astrophysics Data System (ADS)

    Roland, G.; Šafařík, K.; Steinberg, P.

    2014-07-01

    A new era in the study of high-energy nuclear collisions began when the CERN Large Hadron Collider (LHC) provided the first collisions of lead nuclei in late 2010. In the first three years of operation the ALICE, ATLAS and CMS experiments each collected Pb-Pb data samples of more than 50 μb at √{sNN}=2.76 TeV, exceeding the previously studied collision energies by more than an order of magnitude. These data have provided new insights into the properties of QCD matter under extreme conditions, with extensive measurements of soft particle production and newly accessible hard probes of the hot and dense medium. In this review, we provide a comprehensive overview of the results obtained in heavy-ion collisions at the LHC so far, with particular emphasis on the complementary nature of the observations by the three experiments. In particular, the combination of ALICE’s strengths at hadron identification, the strengths of ATLAS and CMS to make precise measurements of high pT probes, and the resourceful measurements of collective flow by all of the experiments have provided a rich and diverse dataset in only a few years. While the basic paradigm established at RHIC - that of a hot, dense medium that flows with a viscosity to shear-entropy ratio near the predicted lower bound, and which degrades the energy of probes, such as jets, heavy-flavours and J/ψ - is confirmed at the LHC, the new data suggest many new avenues for extracting its properties in detail.

  9. Vertex finding with deformable templates at LHC

    NASA Astrophysics Data System (ADS)

    Stepanov, Nikita; Khanov, Alexandre

    1997-02-01

    We present a novel vertex finding technique. The task is formulated as a discrete-continuous optimisation problem in a way similar to the deformable templates approach for the track finding. Unlike the track finding problem, "elastic hedgehogs" rather than elastic arms are used as deformable templates. They are initialised by a set of procedures which provide zero level approximation for vertex positions and track parameters at the vertex point. The algorithm was evaluated using the simulated events for the LHC CMS detector and demonstrated good performance.

  10. Underlying Event Studies for LHC Energies

    SciTech Connect

    Barnafoeldi, Gergely Gabor; Levai, Peter; Agocs, Andras G.

    2011-04-26

    Underlying event was originally defined by the CDF collaboration decades ago. Here we improve the original definition to extend our analysis for events with multiple-jets. We introduce a definition for surrounding rings/belts and based on this definition the jet- and surrounding-belt-excluded areas will provide a good underlying event definition. We inverstigate our definition via the multiplicity in the defined geometry. In parallel, mean transverse momenta of these areas also studied in proton-proton collisions at {radical}(s) = 7 TeV LHC energy.

  11. A Natural Nightmare for the LHC?

    SciTech Connect

    Underwood, Thomas E. J.

    2007-11-20

    A minimal lepton number conserving extension to the Standard Model is considered providing light Dirac neutrinos without resorting to tiny Yukawa couplings. Successful baryogenesis through leptogenesis is not only possible in this case, but even suggests an electroweak scale vacuum expectation value for a gauge singlet scalar in the model. The spectrum contains two massive Higgs bosons and a massless Nambu-Goldstone boson. The existence of the Nambu-Goldstone boson suppresses the Higgs to bb-bar branching ratio and instead Higgs bosons will decay mainly into invisible Goldstone bosons. We consider the constraints on the potential and the implications for the LHC.

  12. A Natural Nightmare for the LHC?

    NASA Astrophysics Data System (ADS)

    Underwood, Thomas E. J.

    2007-11-01

    A minimal lepton number conserving extension to the Standard Model is considered providing light Dirac neutrinos without resorting to tiny Yukawa couplings. Successful baryogenesis through leptogenesis is not only possible in this case, but even suggests an electroweak scale vacuum expectation value for a gauge singlet scalar in the model. The spectrum contains two massive Higgs bosons and a massless Nambu-Goldstone boson. The existence of the Nambu-Goldstone boson suppresses the Higgs to bb¯ branching ratio and instead Higgs bosons will decay mainly into invisible Goldstone bosons. We consider the constraints on the potential and the implications for the LHC.

  13. Early black hole signals at the LHC

    SciTech Connect

    Koch, Ben; Bleicher, Marcus; Stoecker, Horst

    2007-10-26

    The production of mini black holes due to large extra dimensions is a speculative but possible scenario. We survey estimates for di-jet suppression, and multi-mono-jet emission due to black hole production. We further look for a possible sub-scenario which is the formation of a stable or meta-stable black hole remnant (BHR). We show that the beauty of such objects is, that they are relatively easy to observe, even in the early phase of LHC running.

  14. MCFM for the Tevatron and the LHC

    SciTech Connect

    Campbell, John M.; Ellis, R.K.; /Fermilab

    2010-07-01

    A summary is given of the current status of the next-to-leading order (NLO) parton-level integrator MCFM. Some details are given about the Higgs + 2-jet process and the production and decay of t{bar t}, both of which have recently been added to the code. Using MCFM, comparisons between the Tevatron running at {radical}s = 2 TeV and the LHC running at {radical}s = 7 TeV are made for standard model process including the production of Higgs bosons. The case for running the Tevatron until 16fb{sup -1} are accumulated by both detectors is sketched.

  15. Higgs boson at LHC: a diffractive opportunity

    SciTech Connect

    Ducati, M. B. Gay; Silveira, G. G.

    2009-03-23

    An alternative process is presented for diffractive Higgs boson production in peripheral pp collisions, where the particles interact through the Double Pomeron Exchange. The event rate is computed as a central-rapidity distribution for Tevatron and LHC energies leading to a result around 0.6 pb, higher than the predictions from previous approaches. Therefore, this result arises as an enhanced signal for the detection of the Higgs boson in hadron colliders. The predictions for the Higgs boson photoproduction are compared to the ones obtained from a similar approach proposed by the Durham group, enabling an analysis of the future developments of its application to pp and AA collisions.

  16. Particle physics with the LHC data

    NASA Astrophysics Data System (ADS)

    Hagiwara, Kaoru

    2012-07-01

    In this talk, I give reasons why we regard GUT as a part of the Standard Model of Elementary Particle Physics that explain all phenomena observed at high energy experiments and in the universe, with a few notable exceptions. It is based on my introduction-to-elementary-particle-physics lectures for the first year graduate students at Sokendai, Graduate University for Advanced Studies. No new observation is made, but I think that it is important for us to examine the LHC data from the GUT viewpoint together with our fresh students.

  17. Black Holes versus Supersymmetry at the LHC

    NASA Astrophysics Data System (ADS)

    Roy, Arunava; Cavaglia, Marco

    2007-11-01

    Supersymmetry and extra dimensions are the two most promising candidates for new physics at the TeV scale. Supersymmetric particles or extra-dimensional effects could soon be observed at the Large Hadron Collider. In this paper we assess the distinguishability of supersymmetry and black hole events at the LHC. Black hole events are simulated with the CATFISH black hole generator. Supersymmetry simulations use a combination of PYTHIA and ISAJET, the latter providing the mass spectrum. Our analysis shows that supersymmetry and black hole events at the Large Hadron Collider can be easily discriminated.

  18. Early black hole signals at the LHC

    NASA Astrophysics Data System (ADS)

    Koch, Ben; Bleicher, Marcus; Stöcker, Horst

    2007-10-01

    The production of mini black holes due to large extra dimensions is a speculative but possible scenario. We survey estimates for di-jet suppression, and multi-mono-jet emission due to black hole production. We further look for a possible sub-scenario which is the formation of a stable or meta-stable black hole remnant (BHR). We show that the beauty of such objects is, that they are relatively easy to observe, even in the early phase of LHC running.

  19. Constraining flavoured contact interactions at the LHC

    NASA Astrophysics Data System (ADS)

    Davidson, Sacha; Descotes-Genon, Sébastien

    2014-05-01

    Contact interactions are the low-energy footprints of New Physics, so ideally, constraints upon them should be as generic and model independent as possible. Hadron colliders search for four-quark contact interactions with incident valence quarks, and the LHC currently sets limits on a flavour sum (over uu, dd and ud) of selected interactions. We approximately translate these bounds to a more complete (and larger) set of dimension-six interactions of specified flavours. These estimates are obtained at the parton level, are mostly analytic and are less restrictive than the experimental bounds on flavour-summed interactions. The estimates may scale in a simple way to higher energy and luminosity.

  20. LHC searches for exotic new particles

    NASA Astrophysics Data System (ADS)

    Golling, Tobias

    2016-09-01

    A coherent description of the ATLAS and CMS program of searches for physics beyond the Standard Model of particle physics (except supersymmetry) is subject of this review. The theoretical motivation for new phenomena and the associated phenomenology are discussed. The search approach and philosophy by the experiments are presented in detail with illustrative examples both from Run-1 and early Run-2 of the LHC. The searches are largely driven by a diverse set of experimental signatures predicted by the various hypotheses of new physics.

  1. Higgs boson photoproduction at the LHC

    SciTech Connect

    Ducati, M. B. Gay; Silveira, G. G.

    2011-07-15

    We present the current development of the photoproduction approach for the Higgs boson with its application to pp and pA collisions at the LHC. We perform a different analysis for the Gap Survival Probability, where we consider a probability of 3% and also a more optimistic value of 10% based on the HERA data for dijet production. As a result, the cross section for the exclusive Higgs boson production is about 2 fb and 6 fb in pp collisions and 617 and 2056 fb for pPb collisions, considering the gap survival factor of 3% and 10%, respectively.

  2. Tevatron-for-LHC Report: Preparations for Discoveries

    SciTech Connect

    Buescher, V.; Carena, Marcela S.; Dobrescu, Bogdan A.; Mrenna, S.; Rainwater, D.; Schmitt, M.

    2006-08-01

    This is the ''TeV4LHC'' report of the ''Physics Landscapes'' Working Group, focused on facilitating the start-up of physics explorations at the LHC by using the experience gained at the Tevatron. We present experimental and theoretical results that can be employed to probe various scenarios for physics beyond the Standard Model.

  3. The operation of the LHC accelerator complex (1/2)

    ScienceCinema

    None

    2016-07-12

    These lectures will give an overview of what happens when the LHC is in running mode. They are aimed at students working on the LHC experiments, but all those who are curious about what happens behind the scenes of the LHC are welcomed. You will learn all you always wanted to know about the LHC, and never had the courage to ask! The only pre-requisite is a basic, college-level, knowledge of EM and of the principles that allow to steer charged beams. Topics covered will include, among others: - the description of the injector chain, from the generation of the protons, to the delivery of bunches to the LHC. - the discussion of the steps required to accelerate the beams in the LHC, to bring them into collision, and to control the luminosity at the interaction points. - the description of the monitoring tools available to the LHC operators, and an explanation of the various plots and panels that can be found on the LHC web pages. o Lecture 1: Wednesday April 7, 10-11am o Lecture 2: Friday April 9, 10-11am The lectures will be webcast, recorded and archived. Coffee will be served before the lectures, starting at 9:45

  4. The operation of the LHC accelerator complex (2/2)

    ScienceCinema

    None

    2016-07-12

    These lectures will give an overview of what happens when the LHC is in running mode. They are aimed at students working on the LHC experiments, but all those who are curious about what happens behind the scenes of the LHC are welcomed. You will learn all you always wanted to know about the LHC, and never had the courage to ask! The only pre-requisite is a basic, college-level, knowledge of EM and of the principles that allow to steer charged beams. Topics covered will include, among others: - the description of the injector chain, from the generation of the protons, to the delivery of bunches to the LHC. - the discussion of the steps required to accelerate the beams in the LHC, to bring them into collision, and to control the luminosity at the interaction points. - the description of the monitoring tools available to the LHC operators, and an explanation of the various plots and panels that can be found on the LHC web pages. o Lecture 1: Wednesday April 7, 10-11am o Lecture 2: Friday April 9, 10-11am The lectures will be webcast, recorded and archived. Coffee will be served before the lectures, starting at 9:45

  5. Beyond the Standard Model at the LHC and Beyond

    SciTech Connect

    Ellis, John

    2007-11-20

    Many of the open questions beyond the Standard Model will be addressed by the LHC, including the origin of mass, supersymmetry, dark matter and the possibility of large extra dimensions. A linear e{sup +}e{sup -} collider (LC) with sufficient centre-of-mass energy would add considerable value to the capabilities of the LHC.

  6. The operation of the LHC accelerator complex (2/2)

    SciTech Connect

    2010-04-09

    These lectures will give an overview of what happens when the LHC is in running mode. They are aimed at students working on the LHC experiments, but all those who are curious about what happens behind the scenes of the LHC are welcomed. You will learn all you always wanted to know about the LHC, and never had the courage to ask! The only pre-requisite is a basic, college-level, knowledge of EM and of the principles that allow to steer charged beams. Topics covered will include, among others: - the description of the injector chain, from the generation of the protons, to the delivery of bunches to the LHC. - the discussion of the steps required to accelerate the beams in the LHC, to bring them into collision, and to control the luminosity at the interaction points. - the description of the monitoring tools available to the LHC operators, and an explanation of the various plots and panels that can be found on the LHC web pages. o Lecture 1: Wednesday April 7, 10-11am o Lecture 2: Friday April 9, 10-11am The lectures will be webcast, recorded and archived. Coffee will be served before the lectures, starting at 9:45

  7. The operation of the LHC accelerator complex (1/2)

    SciTech Connect

    2010-04-07

    These lectures will give an overview of what happens when the LHC is in running mode. They are aimed at students working on the LHC experiments, but all those who are curious about what happens behind the scenes of the LHC are welcomed. You will learn all you always wanted to know about the LHC, and never had the courage to ask! The only pre-requisite is a basic, college-level, knowledge of EM and of the principles that allow to steer charged beams. Topics covered will include, among others: - the description of the injector chain, from the generation of the protons, to the delivery of bunches to the LHC. - the discussion of the steps required to accelerate the beams in the LHC, to bring them into collision, and to control the luminosity at the interaction points. - the description of the monitoring tools available to the LHC operators, and an explanation of the various plots and panels that can be found on the LHC web pages. o Lecture 1: Wednesday April 7, 10-11am o Lecture 2: Friday April 9, 10-11am The lectures will be webcast, recorded and archived. Coffee will be served before the lectures, starting at 9:45

  8. Predictions for diffraction at the LHC compared to experimental results

    NASA Astrophysics Data System (ADS)

    Goulianos, Konstantin

    2014-04-01

    Diffractive proton-proton cross sections at the LHC, as well as the total and total-inelastic proton-proton cross sections, are predicted in a simple model obeying all unitarity constraints. The model has been implemented in the PYTHIA8-MBR event generator for single diffraction, double diffraction, and central diffraction processes. Predictions of the model are compared to recent LHC results.

  9. {pi} p and {pi}{pi} scattering at LHC

    SciTech Connect

    Ryutin, R.; Petrov, V.; Sobol, A.

    2011-07-15

    Can we get the information on {pi} p and {pi}{pi} scattering from the LHC data? We present briefly recent results of the IHEP Diffractive Group, which include all the steps: formulation of the problem, an idea how to solve it, experimental tools, Monte-Carlo simulation and preliminary expectations concerning the first data from the LHC.

  10. Data-driven model-independent searches for long-lived particles at the LHC

    NASA Astrophysics Data System (ADS)

    Coccaro, Andrea; Curtin, David; Lubatti, H. J.; Russell, Heather; Shelton, Jessie

    2016-12-01

    Neutral long-lived particles (LLPs) are highly motivated by many beyond the Standard Model scenarios, such as theories of supersymmetry, baryogenesis, and neutral naturalness, and present both tremendous discovery opportunities and experimental challenges for the LHC. A major bottleneck for current LLP searches is the prediction of Standard Model backgrounds, which are often impossible to simulate accurately. In this paper, we propose a general strategy for obtaining differential, data-driven background estimates in LLP searches, thereby notably extending the range of LLP masses and lifetimes that can be discovered at the LHC. We focus on LLPs decaying in the ATLAS muon system, where triggers providing both signal and control samples are available at LHC run 2. While many existing searches require two displaced decays, a detailed knowledge of backgrounds will allow for very inclusive searches that require just one detected LLP decay. As we demonstrate for the h →X X signal model of LLP pair production in exotic Higgs decays, this results in dramatic sensitivity improvements for proper lifetimes ≳10 m . In theories of neutral naturalness, this extends reach to glueball masses far below the b ¯b threshold. Our strategy readily generalizes to other signal models and other detector subsystems. This framework therefore lends itself to the development of a systematic, model-independent LLP search program, in analogy to the highly successful simplified-model framework of prompt searches.

  11. The No-Higgs Signal: Strong WW Scattering at the LHC

    SciTech Connect

    Michael S. Chanowitz

    2004-12-07

    Strong WW scattering at the LHC is discussed as a manifestation of electroweak symmetry breaking in the absence of a light Higgs bosom. The general framework of the Higgs mechanism--with or without a Higgs boson--is reviewed, and unitarity is shown to fix the scale of strong WW scattering. Strong WW scattering is also shown to be a possible outcome of five-dimensional models, which do not employ the usual Higgs mechanism at the TeV scale. Precision electroweak constraints are briefly discussed. Illustrative LHC signals are reviewed for models with QCD-like dynamics, stressing the complementarity of the W{sup {+-}}Z and like-charge W{sup +}W{sup +} + W{sup -}W{sup -} channels.

  12. Lepton-flavor-violating decay {tau}{yields}{mu}{mu}{mu} at the CERN LHC

    SciTech Connect

    Giffels, M.; Stahl, A.; Kallarackal, J.; Kraemer, M.; O'Leary, B.

    2008-04-01

    Lepton-flavor-violating {tau} decays are predicted in many extensions of the standard model at a rate observable at future collider experiments. In this article we focus on the decay {tau}{yields}{mu}{mu}{mu}, which is a promising channel to observe lepton-flavor violation at the CERN Large Hadron Collider (LHC). We present analytic expressions for the differential decay width derived from a model-independent effective Lagrangian with general four-fermion operators, and estimate the experimental acceptance for detecting the decay {tau}{yields}{mu}{mu}{mu} at the LHC. Specific emphasis is given to decay angular distributions and how they can be used to discriminate new physics models. We provide specific predictions for various extensions of the standard model, including supersymmetric, little Higgs, and technicolor models.

  13. Particle Physics on the Eve of Lhc

    NASA Astrophysics Data System (ADS)

    Studenikin, Alexander I.

    2009-01-01

    Fundamentals of particle physics. The quantum number of color, colored quarks and dynamic models of Hadrons composed of quasifree quarks / V. Matveev, A. Tavkhelidze. Discovery of the color degree of freedom in particle physics: a personal perspective / O. W. Greenberg. The evolution of the concepts of energy, momentum, and mass from Newton and Lomonosov to Einstein and Feynman / L. Okun -- Physics at accelerators and studies in SM and beyond. Search for new physics at LHC (CMS) / N. Krasnikov. Measuring the Higgs Boson(s) at ATLAS / C. Kourkoumelis. Beyond the standard model physics reach of the ATLAS experiment / G. Unel. The status of the International Linear Collider / B. Foster. Review of results of the electron-proton collider HERA / V. Chekelian. Recent results from the Tevatron on CKM matrix elements from Bs oscillations and single top production, and studies of CP violation in Bs Decays / J. P. Fernández. Direct observation of the strange b Barion [symbol] / L. Vertogradov. Search for new physics in rare B Decays at LHCb / V. Egorychev. CKM angle measurements at LHCb / S. Barsuk. Collider searches for extra spatial dimensions and black holes / G. Landsberg -- Neutrino Physics. Results of the MiniBooNE neutrino oscillation experiment / Z. Djurcic. MINOS results and prospects / J. P. Ochoa-Ricoux. The new result of the neutrino magnetic moment measurement in the GEMMA experiment / A. G. Beda ... [et al.]. The Baikal neutrino experiment: status, selected physics results, and perspectives / V. Aynutdinov ... [et al.]. Neutrino telescopes in the deep sea / V. Flaminio. Double beta decay: present status / A. S. Barabash. Beta-beams / C. Volpe. T2K experiment / K. Sakashita. Non-standard neutrino physics probed by Tokai-to-Kamioka-Korea two-detector complex / N. Cipriano Ribeiro ... [et al.]. Sterile neutrinos: from cosmology to the LHC / F. Vannucci. From Cuoricino to Cuore towards the inverted hierarchy region / C. Nones. The MARE experiment: calorimetric

  14. Beam screen cryogenic control improvements for the LHC run 2

    NASA Astrophysics Data System (ADS)

    Bradu, B.; Rogez, E.; Blanco-Viñuela, E.; Ferlin, G.; Tovar-Gonzalez, A.

    2017-02-01

    This paper presents the improvements made on the cryogenic control system for the LHC beam screens. The regulation objective is to maintain an acceptable temperature range around 20 K which simultaneously ensures a good LHC beam vacuum and limits cryogenic heat loads. In total, through the 27 km of the LHC machine, there are 485 regulation loops affected by beam disturbances. Due to the increase of the LHC performance during Run 2, standard PID controllers cannot keeps the temperature transients of the beam screens within desired limits. Several alternative control techniques have been studied and validated using dynamic simulation and then deployed on the LHC cryogenic control system in 2015. The main contribution is the addition of a feed-forward control in order to compensate the beam effects on the beam screen temperature based on the main beam parameters of the machine in real time.

  15. Turning the LHC ring into a new physics search machine

    NASA Astrophysics Data System (ADS)

    Orava, Risto

    2017-03-01

    The LHC Collider Ring is proposed to be turned into an ultimate automatic search engine for new physics in four consecutive phases: (1) Searches for heavy particles produced in Central Exclusive Process (CEP): pp → p + X + p based on the existing Beam Loss Monitoring (BLM) system of the LHC; (2) Feasibility study of using the LHC Ring as a gravitation wave antenna; (3) Extensions to the current BLM system to facilitate precise registration of the selected CEP proton exit points from the LHC beam vacuum chamber; (4) Integration of the BLM based event tagging system together with the trigger/data acquisition systems of the LHC experiments to facilitate an on-line automatic search machine for the physics of tomorrow.

  16. Upgrades of the CMS Outer Tracker for HL-LHC

    NASA Astrophysics Data System (ADS)

    Sguazzoni, Giacomo

    2017-02-01

    The LHC machine is planning an upgrade program which will smoothly bring the luminosity to about 5 ×1034cm-2s-1 around 2028, to possibly reach an integrated luminosity of 3000 fb-1 in the following decade. This High Luminosity LHC scenario, HL-LHC, will require a preparation program of the LHC detectors known as Phase-2 upgrade. The current CMS Outer Tracker, already running close to its design limits, will not be able to survive HL-LHC radiation conditions and CMS will need a completely new device, in order to fully exploit the highly demanding operating conditions and the delivered luminosity. The new Tracker should have also L1 trigger capabilities. To achieve such goals, R&D activities are ongoing to explore options and develop solutions that would allow including tracking information at Level-1. The design choices for the CMS Outer Tracker upgrades are discussed along with some highlights of the R&D activities.

  17. Simplified Models for LHC New Physics Searches

    SciTech Connect

    Alves, Daniele; Arkani-Hamed, Nima; Arora, Sanjay; Bai, Yang; Baumgart, Matthew; Berger, Joshua; Buckley, Matthew; Butler, Bart; Chang, Spencer; Cheng, Hsin-Chia; Cheung, Clifford; Chivukula, R.Sekhar; Cho, Won Sang; Cotta, Randy; D'Alfonso, Mariarosaria; El Hedri, Sonia; Essig, Rouven,; Evans, Jared A.; Fitzpatrick, Liam; Fox, Patrick; Franceschini, Roberto; /more authors..

    2012-06-01

    This document proposes a collection of simplified models relevant to the design of new-physics searches at the LHC and the characterization of their results. Both ATLAS and CMS have already presented some results in terms of simplified models, and we encourage them to continue and expand this effort, which supplements both signature-based results and benchmark model interpretations. A simplified model is defined by an effective Lagrangian describing the interactions of a small number of new particles. Simplified models can equally well be described by a small number of masses and cross-sections. These parameters are directly related to collider physics observables, making simplified models a particularly effective framework for evaluating searches and a useful starting point for characterizing positive signals of new physics. This document serves as an official summary of the results from the 'Topologies for Early LHC Searches' workshop, held at SLAC in September of 2010, the purpose of which was to develop a set of representative models that can be used to cover all relevant phase space in experimental searches. Particular emphasis is placed on searches relevant for the first {approx} 50-500 pb{sup -1} of data and those motivated by supersymmetric models. This note largely summarizes material posted at http://lhcnewphysics.org/, which includes simplified model definitions, Monte Carlo material, and supporting contacts within the theory community. We also comment on future developments that may be useful as more data is gathered and analyzed by the experiments.

  18. Naturally flavorful supersymmetry at the LHC

    SciTech Connect

    Nomura, Yasunori; Stolarski, Daniel

    2008-11-01

    The suppression of flavor and CP violation in supersymmetric theories may be due to the mechanism responsible for the structure of the Yukawa couplings. We study model independently the compatibility between low-energy flavor and CP constraints and observability of superparticles at the LHC, assuming a generic correlation between the Yukawa couplings and the supersymmetry breaking parameters. We find that the superpotential operators that generate scalar trilinear interactions are generically problematic. We discuss several ways in which this tension is naturally avoided. In particular, we focus on several frameworks in which the dangerous operators are naturally absent. These frameworks can be combined with many theories of flavor, including those with (flat or warped) extra dimensions, strong dynamics, or flavor symmetries. We show that the resulting theories can avoid all the low-energy constraints while keeping the superparticles light. The intergenerational mass splittings among the sfermions can reflect the structure of the underlying flavor theory, and can be large enough to be measurable at the LHC. Detailed observations of the superparticle spectrum may thus provide new handles on the origin of the flavor structure of the standard model.

  19. Electroweak Corrections at the LHC with MCFM

    SciTech Connect

    Campbell, John M.; Wackeroth, Doreen; Zhou, Jia

    2015-07-10

    Electroweak (EW) corrections at the LHC can be enhanced at high energies due to soft/collinear radiation of W and Z bosons, being dominated by Sudakov-like corrections in the form of $\\alpha_W^l\\log^n(Q^2/M_W^2)$ $(n \\le 2l, \\alpha_W = \\alpha/(4\\pi\\sin\\theta_W^2))$ when the energy scale $Q$ enters the TeV regime. Thus, the inclusion of EW corrections in LHC predictions is important for the search of possible signals of new physics in tails of kinematic distributions. EW corrections should also be taken into account in virtue of their comparable size ($\\mathcal{O}(\\alpha)$) to that of higher order QCD corrections ($\\mathcal{O}(\\alpha_s^2)$). We calculated the next-to-leading-order (NLO) weak corrections to the neutral-current (NC) Drell-Yan process, top-quark pair production and di-jet producion, and implemented them in the Monte-Carlo program MCFM. This enables a combined study with the corresponding NLO QCD corrections. We provide both the full NLO weak corrections and their weak Sudakov approximation valid at high energies. The latter is often used for a fast evaluation of weak effects, and having the exact result available as well allows to quantify the validity of the Sudakov approximation.

  20. Novel Geometries for the LHC Crab Cavity

    SciTech Connect

    Hall, B.; Burt, G.; Smith, J. D.A.; Rimmer, R.; Wang, H.; Delayen, J.; Calaga, R.

    2009-05-01

    In 2017 the LHC is envisioned to increase its luminosity via an upgrade. This upgrade is likely to require a large crossing angle hence a crab cavity is required to align the bunches prior to collision. There are two possible schemes for crab cavity implementation, global and local. In a global crab cavity the crab cavity is far from the IP and the bunch rotates back and forward as it traverses around the accelerator in a closed orbit. For this scheme a two-cell elliptical squashed cavity at 800 MHz is preferred. To avoid any potential beam instabilities all the parasitic modes of the cavities must be damped strongly, however crab cavities have lower order and same order modes in addition to the usual higher order modes and hence a novel damping scheme must be used to provide sufficient damping of these modes. In the local scheme two crab cavities are placed at each side of the IP two start and stop rotation of the bunches. This would require crab cavities much smaller transversely than in the global scheme but the frequency cannot be increased any higher due to the long bunch length of the LHC beam. This will require a novel compact crab cavity design. A superconducting version of a two rod coaxial deflecting cavity as a suitable design is proposed in this paper.

  1. Light exotic Higgs bosons at the LHC

    NASA Astrophysics Data System (ADS)

    Munir, Shoaib

    2017-07-01

    Most models of new physics contain extended Higgs sectors with multiple Higgs bosons. The observation of an additional Higgs boson, besides the ∼ 125 GeV ‘hobs ’, will thus serve as an irrefutable evidence of physics beyond the Standard Model (SM). However, even when fairly light, these additional Higgs bosons may still have escaped detection at the Large Electron-Positron (LEP) collider, the Tevatron and the Large Hadron Collider (LHC) hitherto, owing to their highly reduced couplings to the SM particles. Therefore, in addition to the searches based on the conventional production processes of these Higgs bosons, such as gluon or vector boson fusion, possible new search modes need to be exploited at collider experiments in order to establish their signatures. We investigate here the phenomenology of pseudoscalars, with masses ranging from {O}(1) GeV to about 150 GeV, in the Next-to-Minimal Supersymmetric SM (NMSSM) and the Type-I 2-Higgs Doublet Model (2HDM) in some such atypical search channels at the LHC Run-II.

  2. MSSM Electroweak Baryogenesis and LHC Data

    SciTech Connect

    Carena, Marcela; Nardini, Germano; Quiros, Mariano; Wagner, Carlos E.M.

    2013-02-01

    Electroweak baryogenesis is an attractive scenario for the generation of the baryon asymmetry of the universe as its realization depends on the presence at the weak scale of new particles which may be searched for at high energy colliders. In the MSSM it may only be realized in the presence of light stops, and with moderate or small mixing between the left- and right-handed components. Consistency with the observed Higgs mass around 125 GeV demands the heavier stop mass to be much larger than the weak scale. Moreover the lighter stop leads to an increase of the gluon-gluon fusion Higgs production cross section which seems to be in contradiction with indications from current LHC data. We show that this tension may be considerably relaxed in the presence of a light neutralino with a mass lower than about 60 GeV, satisfying all present experimental constraints. In such a case the Higgs may have a significant invisible decay width and the stop decays through a three or four body decay channel, including a bottom quark and the lightest neutralino in the final state. All these properties make this scenario testable at a high luminosity LHC.

  3. Medical Imaging Inspired Vertex Reconstruction at LHC

    NASA Astrophysics Data System (ADS)

    Hageböck, S.; von Toerne, E.

    2012-12-01

    Three-dimensional image reconstruction in medical applications (PET or X-ray CT) utilizes sophisticated filter algorithms to linear trajectories of coincident photon pairs or x-rays. The goal is to reconstruct an image of an emitter density distribution. In a similar manner, tracks in particle physics originate from vertices that need to be distinguished from background track combinations. In this study it is investigated if vertex reconstruction in high energy proton collisions may benefit from medical imaging methods. A new method of vertex finding, the Medical Imaging Vertexer (MIV), is presented based on a three-dimensional filtered backprojection algorithm. It is compared to the open-source RAVE vertexing package. The performance of the vertex finding algorithms is evaluated as a function of instantaneous luminosity using simulated LHC collisions. Tracks in these collisions are described by a simplified detector model which is inspired by the tracking performance of the LHC experiments. At high luminosities (25 pileup vertices and more), the medical imaging approach finds vertices with a higher efficiency and purity than the RAVE “Adaptive Vertex Reconstructor” algorithm. It is also much faster if more than 25 vertices are to be reconstructed because the amount of CPU time rises linearly with the number of tracks whereas it rises quadratically for the adaptive vertex fitter AVR.

  4. Simplified models for LHC new physics searches

    NASA Astrophysics Data System (ADS)

    Alves, Daniele; Arkani-Hamed, Nima; Arora, Sanjay; Bai, Yang; Baumgart, Matthew; Berger, Joshua; Buckley, Matthew; Butler, Bart; Chang, Spencer; Cheng, Hsin-Chia; Cheung, Clifford; Sekhar Chivukula, R.; Cho, Won Sang; Cotta, Randy; D'Alfonso, Mariarosaria; El Hedri, Sonia; Essig (Editor, Rouven; Evans, Jared A.; Fitzpatrick, Liam; Fox, Patrick; Franceschini, Roberto; Freitas, Ayres; Gainer, James S.; Gershtein, Yuri; Gray, Richard; Gregoire, Thomas; Gripaios, Ben; Gunion, Jack; Han, Tao; Haas, Andy; Hansson, Per; Hewett, JoAnne; Hits, Dmitry; Hubisz, Jay; Izaguirre, Eder; Kaplan, Jared; Katz, Emanuel; Kilic, Can; Kim, Hyung-Do; Kitano, Ryuichiro; Koay, Sue Ann; Ko, Pyungwon; Krohn, David; Kuflik, Eric; Lewis, Ian; Lisanti (Editor, Mariangela; Liu, Tao; Liu, Zhen; Lu, Ran; Luty, Markus; Meade, Patrick; Morrissey, David; Mrenna, Stephen; Nojiri, Mihoko; Okui, Takemichi; Padhi, Sanjay; Papucci, Michele; Park, Michael; Park, Myeonghun; Perelstein, Maxim; Peskin, Michael; Phalen, Daniel; Rehermann, Keith; Rentala, Vikram; Roy, Tuhin; Ruderman, Joshua T.; Sanz, Veronica; Schmaltz, Martin; Schnetzer, Stephen; Schuster (Editor, Philip; Schwaller, Pedro; Schwartz, Matthew D.; Schwartzman, Ariel; Shao, Jing; Shelton, Jessie; Shih, David; Shu, Jing; Silverstein, Daniel; Simmons, Elizabeth; Somalwar, Sunil; Spannowsky, Michael; Spethmann, Christian; Strassler, Matthew; Su, Shufang; Tait (Editor, Tim; Thomas, Brooks; Thomas, Scott; Toro (Editor, Natalia; Volansky, Tomer; Wacker (Editor, Jay; Waltenberger, Wolfgang; Yavin, Itay; Yu, Felix; Zhao, Yue; Zurek, Kathryn; LHC New Physics Working Group

    2012-10-01

    This document proposes a collection of simplified models relevant to the design of new-physics searches at the Large Hadron Collider (LHC) and the characterization of their results. Both ATLAS and CMS have already presented some results in terms of simplified models, and we encourage them to continue and expand this effort, which supplements both signature-based results and benchmark model interpretations. A simplified model is defined by an effective Lagrangian describing the interactions of a small number of new particles. Simplified models can equally well be described by a small number of masses and cross-sections. These parameters are directly related to collider physics observables, making simplified models a particularly effective framework for evaluating searches and a useful starting point for characterizing positive signals of new physics. This document serves as an official summary of the results from the ‘Topologies for Early LHC Searches’ workshop, held at SLAC in September of 2010, the purpose of which was to develop a set of representative models that can be used to cover all relevant phase space in experimental searches. Particular emphasis is placed on searches relevant for the first ˜50-500 pb-1 of data and those motivated by supersymmetric models. This note largely summarizes material posted at http://lhcnewphysics.org/, which includes simplified model definitions, Monte Carlo material, and supporting contacts within the theory community. We also comment on future developments that may be useful as more data is gathered and analyzed by the experiments.

  5. CERN LHC signals from warped extra dimensions

    SciTech Connect

    Agashe, Kaustubh; Belyaev, Alexander; Krupovnickas, Tadas; Perez, Gilad; Virzi, Joseph

    2008-01-01

    We study production of Kaluza-Klein (KK) gluons at the Large Hadron Collider (LHC) in the framework of a warped extra dimension with the standard model fields propagating in the bulk. We show that the detection of the KK gluon is challenging since its production is suppressed by small couplings to the proton's constituents. Moreover, the KK gluon decays mostly to top pairs due to an enhanced coupling and hence is broad. Nevertheless, we demonstrate that for M{sub KKG} < or approx. 4 TeV, 100 fb{sup -1} of data at the LHC can provide discovery of the KK gluon. We utilize a sizable left-right polarization asymmetry from the KK gluon resonance to maximize the signal significance, and we explore the novel feature of extremely highly energetic 'top-jets'. We briefly discuss how the detection of electroweak gauge KK states (Z/W) faces a similar challenge since their leptonic decays (golden modes) are suppressed. Our analysis suggests that other frameworks, for example, little Higgs, which rely on UV completion via strong dynamics might face similar challenges, namely, (1) suppressed production rates for the new particles (such as Z{sup '}), due to their 'light-fermion-phobic' nature, and (2) difficulties in detection since the new particles are broad and decay predominantly to third generation quarks and longitudinal gauge bosons.

  6. LHC Signals from Warped Extra Dimensions

    SciTech Connect

    Agashe, K.; Belyaev, A.; Krupovnickas, T.; Perez, G.; Virzi, J.

    2006-12-06

    We study production of Kaluza-Klein gluons (KKG) at the Large Hadron Collider (LHC) in the framework of a warped extra dimension with the Standard Model (SM) fields propagating in the bulk. We show that the detection of KK gluon is challenging since its production is suppressed by small couplings to the proton's constituents. Moreover, the KK gluon decaysmostly to top pairs due to an enhanced coupling and hence is broad. Nevertheless, we demonstrate that for MKKG<~;; 4 TeV, 100 fb-1 of data at the LHC can provide discovery of the KK gluon. We utilize a sizeable left-right polarization asymmetry from the KK gluon resonance to maximize the signal significance, and we explore the novel feature of extremely highly energetic"top-jets." We briefly discuss how the detection of electroweak gauge KK states (Z/W) faces a similar challenge since their leptonic decays ("golden" modes) are suppressed. Our analysis suggests that other frameworks, for example little Higgs, which rely on UV completion via strong dynamics might face similar challenges, namely (1) Suppressed production rates for the new particles (such as Z'), due to their"lightfermion-phobic" nature, and (2) Difficulties in detection since the new particles are broad and decay predominantly to third generation quarks and longitudinal gauge bosons.

  7. Techni-Dilaton Signatures at LHC

    NASA Astrophysics Data System (ADS)

    Matsuzaki, S.; Yamawaki, K.

    2012-02-01

    We explore discovery signatures of techni-dilaton (TD) at LHC. The TD was predicted long ago as a composite pseudo Nambu-Goldstone boson (pNGB) associated with the spontaneous breaking of the approximate scale symmetry in the walking technicolor (WTC) (initially dubbed ``scale-invariant technicolor''). Being pNGB, whose mass arises from the explicit scale-symmetry breaking due to the spontaneous breaking itself (dynamical mass generation), the TD as a composite scalar should have a mass M_{TD} lighter than other techni-hadrons, say M_{TD} ≃ 600 GeV for the typical WTC model, which is well in the discovery range of the ongoing LHC experiment. We develop a spurion method of nonlinear realization to calculate the TD couplings to the standard model (SM) particles and explicitly evaluate the TD LHC production cross sections at √{s} = 7 TeV times the branching ratios in terms of M_{TD} as an input parameter for the region 200 GeV < M_{TD} < 1000 GeV in the typical WTC models. It turns out that the TD signatures are quite different from those of the SM Higgs: In the one-doublet model (1DM) all the cross sections including the WW/ZZ mode are suppressed compared to those of the SM Higgs due to the suppressed TD couplings, while in the one-family model (1FM) all those cross sections get highly enhanced because of the presence of extra colored fermion (techni-quark) contributions. We compare the {TD} → WW/ZZ signature with the recent ATLAS and CMS bounds and find that in the case of 1DM the signature is consistent over the whole mass range 200 GeV < M_{TD} < 1000 GeV due to the large suppression of TD couplings, and by the same token the signal is too tiny for the TD to be visible through this channel at LHC. As for the 1FMs, on the other hand, a severe constraint is given on the TD mass to exclude the TD with mass ≲ 600 GeV, which, however, would imply an emergence of somewhat dramatic excess as the TD signature at 600 GeV ≲ M_{TD} < 1000 GeV in the near future. We

  8. Spin and diffractive physics with a fixed-target experiment at the LHC (AFTER-LHC)

    SciTech Connect

    Lorce, C.; Chambert, V.; Didelez, J. P.; Genolini, B.; Hadjidakis, C.; Lansberg, J. P.; Rosier, P.; Brodsky, S. J.; Ferreiro, E. G.; Fleuret, F.

    2013-04-15

    We report on the spin and diffractive physics at a future multi-purpose f xed-target experiment with proton and lead LHC beams extracted by a bent crystal. The LHC multi-TeV beams allow for the most energetic f xed-target experiments ever performed, opening new domains of particle and nuclear physics and complementing that of collider physics, in particular that of RHIC and the EIC projects. The luminosity achievable with AFTER using typical targets would surpass that of RHIC by more than 3 orders of magnitude. The f xed-target mode has the advantage to allow for measurements of single-spin asymmetries with polarized target as well as of single-diffractive processes in the target region.

  9. Performance of the cold powered diodes and diode leads in the main magnets of the LHC

    NASA Astrophysics Data System (ADS)

    Willering, G. P.; Giloux, C.; Bajko, M.; Bednarek, M.; Bottura, L.; Charifoulline, Z.; Dahlerup-Petersen, K.; Dib, G.; D'Angelo, G.; Gharib, A.; Grand-Clement, L.; Izquierdo Bermudez, S.; Prin, H.; Roger, V.; Rowan, S.; Savary, F.; Tock, J.-Ph; Verweij, A.

    2015-12-01

    During quench tests in 2011 variations in resistance of an order of magnitude were found in the diode by-pass circuit of the main LHC magnets. An investigation campaign was started to understand the source, the occurrence and the impact of the high resistances. Many tests were performed offline in the SM18 test facility with a focus on the contact resistance of the diode to heat sink contact and the diode wafer temperature. In 2014 the performance of the diodes and diode leads of the main dipole bypass systems in the LHC was assessed during a high current qualification test. In the test a current cycle similar to a magnet circuit discharge from 11 kA with a time constant of 100 s was performed. Resistances of up to 600 μΩ have been found in the diode leads at intermediate current, but in general the high resistances decrease at higher current levels and no sign of overheating of diodes has been seen and the bypass circuit passed the test. In this report the performance of the diodes and in particular the contact resistances in the diode leads are analysed with available data acquired over more than 10 years from acceptance test until the main dipole training campaign in the LHC in 2015.

  10. Commissioning of the cryogenics of the LHC long straight sections

    SciTech Connect

    Perin, A.; Casas-Cubillos, J.; Claudet, S.; Darve, C.; Ferlin, G.; Millet, F.; Parente, C.; Rabehl, R.; Soubiran, M.; van Weelderen, R.; Wagner, U.; /CERN

    2010-01-01

    The LHC is made of eight circular arcs interspaced with eight Long Straight Sections (LSS). Most powering interfaces to the LHC are located in these sections where the particle beams are focused and shaped for collision, cleaning and acceleration. The LSSs are constituted of several unique cryogenic devices and systems like electrical feed-boxes, standalone superconducting magnets, superconducting links, RF cavities and final focusing superconducting magnets. This paper presents the cryogenic commissioning and the main results obtained during the first operation of the LHC Long Straight Sections.

  11. ADVANCES TOWARDS THE MEASUREMENT AND CONTROL LHC TUNE AND CHROMATICITY

    SciTech Connect

    CAMERON, P.; CUPOLO, J.; DEGEN, C.; DELLAPENNA, A.; HOFF, L.; MEAD, J.; SIKORA, R.

    2005-06-06

    Requirements for tune and chromaticity control in most superconducting hadron machines, and in particular the LHC, are stringent. In order to reach nominal operation, the LHC will almost certainly require feedback on both tune and chromaticity. Experience at RHIC has also shown that coupling control is crucial to successful tune feedback. A prototype baseband phase-locked loop (PLL) tune measurement system has recently been brought into operation at RHIC as part of the US LHC Accelerator Research Program (LARP). We report on the performance of that system and compare it with the extensive accumulation of data from the RHIC 245MHz PLL.

  12. SPS Beam Steering for LHC Extraction

    SciTech Connect

    Gianfelice-Wendt, Eliana; Bartosik, Hannes; Cornelis, Karel; Norderhaug Drøsdal, Lene; Goddard, Brennan; Kain, Verena; Meddahi, Malika; Papaphilippou, Yannis; Wenninger, Jorg

    2014-07-01

    The CERN Super Proton Synchrotron accelerates beams for the Large Hadron Collider to 450 GeV. In addition it produces beams for fixed target facilities which adds complexity to the SPS operation. During the run 2012-2013 drifts of the extracted beam trajectories have been observed and lengthy optimizations in the transfer lines were performed to reduce particle losses in the LHC. The observed trajectory drifts are consistent with the measured SPS orbit drifts at extraction. While extensive studies are going on to understand, and possibly suppress, the source of such SPS orbit drifts the feasibility of an automatic beam steering towards a “golden” orbit at the extraction septa, by means of the interlocked correctors, is also being investigated. The challenges and constraints related to the implementation of such a correction in the SPS are described. Simulation results are presented and a possible operational steering strategy is proposed.

  13. Jet measurements by ALICE at LHC

    SciTech Connect

    Sultanov, Rishat; Collaboration: ALICE Collaboration

    2015-12-15

    Jets are collimated sprays of particles originating from fragmentation of high energy partons produced in a hard collision. They are an important diagnostic tool in studies of the Quark Gluon Plasma (QGP). The modification of the jet fragmentation pattern and its structure is a signature for the influence of hot and dense matter on the parton fragmentation process. Jet measurements in proton-proton collisions provide a baseline for similar measurements in heavy-ion collisions, while studies in proton-nucleus system allow to estimate cold nuclear matter effects. Here we present jet studies in different colliding systems (p–p, p–Pb, Pb–Pb) performed by the ALICE collaboration at LHC energies. Results on jet spectra, cross sections, nuclear modification factors, jet structure and other kinematic observables will be presented.

  14. Unification and new particles at the LHC

    NASA Astrophysics Data System (ADS)

    Arkani-Hamed, Nima; D'Agnolo, Raffaele Tito; Low, Matthew; Pinner, David

    2016-11-01

    Precision gauge coupling unification is one of the primary quantitative successes of low energy or split supersymmetry. Preserving this success puts severe restrictions on possible matter and gauge sectors that might appear at collider-accessible energies. In this work we enumerate new gauge sectors which are compatible with unification, consisting of horizontal gauge groups acting on vector-like matter charged under the Standard Model. Interestingly, almost all of these theories are in the supersymmetric conformal window at high energies and confine quickly after the superpartners are decoupled. For a range of scalar masses compatible with both moderately tuned and minimally split supersymmetry, the confining dynamics happen at the multi-TeV scale, leading to a spectrum of multiple spin-0 and spin-1 resonances accessible to the LHC, with unusual quantum numbers and striking decay patterns.

  15. Silicon beam telescope for LHC upgrade tests

    SciTech Connect

    Maenpaa, T.; Luukka, P.; Betchart, B.; Czellar, S.; Demina, R.; Gotra, Y.; Frey, M.; Hartmann, F.; Harkonen, J.; Korjenevski, S.; Kortelainen, M.J.; /Helsinki Inst. of Phys. /Helsinki Inst. of Phys.

    2008-01-01

    A beam telescope based on the CMS Tracker data acquisition prototype cards has been developed in order to test sensor candidates for S-LHC tracking systems. The telescope consists of up to eight reference silicon microstrip modules and slots for a couple of test modules. Beam tracks, as measured by the reference modules, provide a means of determining the position resolution and efficiency of the test modules. The impact point precision of reference tracks at the location of the test modules is about 4 {micro}m. This note presents a detailed description of the silicon beam telescope (SiBT) along with some results from its initial operation in summer 2007 in the CERN H2 beamline.

  16. Unification and new particles at the LHC

    DOE PAGES

    Arkani-Hamed, Nima; D’Agnolo, Raffaele Tito; Low, Matthew; ...

    2016-11-14

    Precision gauge coupling uni cation is one of the primary quantitative successes of low energy or split supersymmetry. Preserving this success puts severe restrictions on possible matter and gauge sectors that might appear at collider-accessible energies. In this study we enumerate new gauge sectors which are compatible with uni cation, consisting of horizontal gauge groups acting on vector-like matter charged under the Standard Model. Interestingly, almost all of these theories are in the supersymmetric conformal window at high energies and con ne quickly after the superpartners are decoupled. For a range of scalar masses compatible with both moderately tuned andmore » minimally split supersymmetry, the con ning dynamics happen at the multi-TeV scale, leading to a spectrum of multiple spin-0 and spin-1 resonances accessible to the LHC, with unusual quantum numbers and striking decay patterns.« less

  17. Symmetry restored in dibosons at the LHC?

    DOE PAGES

    Brehmer, Johann; Hewett, JoAnne; Kopp, Joachim; ...

    2015-10-28

    A number of LHC resonance search channels display an excess in the invariant mass region of 1.8–2.0 TeV. Among them is a 3.4σ excess in the fully hadronic decay of a pair of Standard Model electroweak gauge bosons, in addition to potential signals in the HW and dijet final states. We perform a model-independent cross-section fit to the results of all ATLAS and CMS searches sensitive to these final states. We then interpret these results in the context of the Left-Right Symmetric Model, based on the extended gauge group SU(2)L × SU(2)R × U(1)', and show that a heavy right-handedmore » gauge boson WR can naturally explain the current measurements with just a single coupling gR ~ 0.4. Thus, we discuss a possible connection to dark matter.« less

  18. Unification and new particles at the LHC

    SciTech Connect

    Arkani-Hamed, Nima; D’Agnolo, Raffaele Tito; Low, Matthew; Pinner, David

    2016-11-14

    Precision gauge coupling uni cation is one of the primary quantitative successes of low energy or split supersymmetry. Preserving this success puts severe restrictions on possible matter and gauge sectors that might appear at collider-accessible energies. In this study we enumerate new gauge sectors which are compatible with uni cation, consisting of horizontal gauge groups acting on vector-like matter charged under the Standard Model. Interestingly, almost all of these theories are in the supersymmetric conformal window at high energies and con ne quickly after the superpartners are decoupled. For a range of scalar masses compatible with both moderately tuned and minimally split supersymmetry, the con ning dynamics happen at the multi-TeV scale, leading to a spectrum of multiple spin-0 and spin-1 resonances accessible to the LHC, with unusual quantum numbers and striking decay patterns.

  19. Hadroproduction of heavy quarkonia at the LHC

    SciTech Connect

    Berezhnoy, A. V.; Likhoded, A. K.; Luchinsky, A. V. Poslavsky, S. V.

    2015-05-15

    The production of heavy quarkonia at the LHC is considered. It is shown that, in the case of the inclusive production of χ{sub cJ}P-wave charmonia, existing experimental data can be described upon taking into account next-to-leading corrections, a dominant contribution coming from color-singlet states. For the case of B{sub c}-meson production, it is shown that, at experimentally accessible values of the transverse momentum, power-law corrections to the cross section make a significant contribution, with the result that the cross-section ratio σ(B{sub c})/σ(B) develops a p{sub T} dependence not observed in the fragmentation regime. The case of double vector-charmonium production is also considered.

  20. Top B physics at the LHC.

    PubMed

    Gedalia, Oram; Isidori, Gino; Maltoni, Fabio; Perez, Gilad; Selvaggi, Michele; Soreq, Yotam

    2013-06-07

    In top-pair events where at least one of the tops decays semileptonically, the identification of the lepton charge allows us to tag not only the top quark charge but also that of the subsequent b quark. In cases where the b also decays semileptonically, the charge of the two leptons can be used to probe CP violation in heavy flavor mixing and decays. This strategy to measure CP violation is independent of those adopted so far in experiments, and can already constrain non standard model sources of CP violation with current and near future LHC data. To demonstrate the potential of this method we construct two CP asymmetries based on same-sign and opposite-sign leptons and estimate their sensitivities. This proposal opens a new window for doing precision measurements of CP violation in b and c quark physics via high p(T) processes at ATLAS and CMS.

  1. LHC constraints on color octet scalars

    NASA Astrophysics Data System (ADS)

    Hayreter, Alper; Valencia, German

    2017-08-01

    We extract constraints on the parameter space of the Manohar and Wise model by comparing the cross sections for dijet, top-pair, dijet-pair, t t ¯t t ¯ and b b ¯b b ¯ productions at the LHC with the strongest available experimental limits from ATLAS or CMS at 8 or 13 TeV. Overall we find mass limits around 1 TeV in the most sensitive regions of parameter space, and lower elsewhere. This is at odds with generic limits for color octet scalars often quoted in the literature where much larger production cross sections are assumed. The constraints that can be placed on coupling constants are typically weaker than those from existing theoretical considerations, with the exception of the parameter ηD.

  2. Operational results from the LHC luminosity monitors

    SciTech Connect

    Miyamoto, R.; Ratti, A.; Matis, H.S.; Stezelberger, T.; Turner, W.C.; Yaver, H.; Bravin, E.

    2011-03-28

    The luminosity monitors for the high luminosity regions in the LHC have been operating to monitor and optimize the luminosity since 2009. The device is a gas ionization chamber inside the neutral particle absorber 140 m from the interaction point and monitors showers produced by high energy neutral particles from the collisions. It has the ability to resolve the bunch-by-bunch luminosity as well as to survive the extreme level of radiation in the nominal LHC operation. We present operational results of the device during proton and lead ion operations in 2010 and make comparisons with measurements of experiments. The Large Hadron Collider (LHC) at CERN can accelerate proton and lead ion beams to 7 TeV and 547 TeV and produce collisions of these particles. Luminosity measures performance of the LHC and is particularly important for experiments in high luminosity interaction points (IPs), ATLAS (IP1) and CMS (IP5). To monitor and optimize the luminosities of these IPs, BRAN (Beam RAte Neutral) detectors [1, 2] have been installed and operating since the beginning of the 2009 operation [3]. A neutral particle absorber (TAN) protects the D2 separation dipole from high energy forward neutral particles produced in the collisions [4]. These neutral particles produce electromagnetic and hadronic showers inside the TAN and their energy flux is proportional to the collision rate and hence to the luminosity. The BRAN detector is an Argon gas ionization chamber installed inside the TANs on both sides of the IP1 and IP5 and monitors the relative changes in the luminosity by detecting the ionization due to these showers. When the number of collisions per bunch crossing (multiplicity) is small, the shower rate inside the TAN is also proportional to the luminosity. Hence, the detector is designed to operate by measuring either the shower rate (counting mode for low and intermediate luminosities) or the average shower flux (pulse height mode for high luminosities). The detector is

  3. Hiding a Heavy Higgs Boson at the 7 TeV LHC

    SciTech Connect

    Bai, Yang; Fan, JiJi; Hewett, JoAnne L.

    2012-03-20

    A heavy Standard Model Higgs boson is not only disfavored by electroweak precision observables but is also excluded by direct searches at the 7 TeV LHC for a wide range of masses. Here, we examine scenarios where a heavy Higgs boson can be made consistent with both the indirect constraints and the direct null searches by adding only one new particle beyond the Standard Model. This new particle should be a weak multiplet in order to have additional contributions to the oblique parameters. If it is a color singlet, we find that a heavy Higgs with an intermediate mass of 200-300 GeV can decay into the new states, suppressing the branching ratios for the standard model modes, and thus hiding a heavy Higgs at the LHC. If the new particle is also charged under QCD, the Higgs production cross section from gluon fusion can be reduced significantly due to the new colored particle one-loop contribution. Current collider constraints on the new particles allow for viable parameter space to exist in order to hide a heavy Higgs boson. We categorize the general signatures of these new particles, identify favored regions of their parameter space and point out that discovering or excluding them at the LHC can provide important indirect information for a heavy Higgs. Finally, for a very heavy Higgs boson, beyond the search limit at the 7 TeV LHC, we discuss three additional scenarios where models would be consistent with electroweak precision tests: including an additional vector-like fermion mixing with the top quark, adding another U(1) gauge boson and modifying triple-gauge boson couplings.

  4. The NUHM2 after LHC Run 1.

    PubMed

    Buchmueller, O; Cavanaugh, R; Citron, M; De Roeck, A; Dolan, M J; Ellis, J R; Flächer, H; Heinemeyer, S; Malik, S; Marrouche, J; Martínez Santos, D; Olive, K A; de Vries, K J; Weiglein, G

    We make a frequentist analysis of the parameter space of the NUHM2, in which the soft supersymmetry (SUSY)-breaking contributions to the masses of the two Higgs multiplets, [Formula: see text], vary independently from the universal soft SUSY-breaking contributions [Formula: see text] to the masses of squarks and sleptons. Our analysis uses the MultiNest sampling algorithm with over [Formula: see text] points to sample the NUHM2 parameter space. It includes the ATLAS and CMS Higgs mass measurements as well as the ATLAS search for supersymmetric jets + [Formula: see text] signals using the full LHC Run 1 data, the measurements of [Formula: see text] by LHCb and CMS together with other B-physics observables, electroweak precision observables and the XENON100 and LUX searches for spin-independent dark-matter scattering. We find that the preferred regions of the NUHM2 parameter space have negative SUSY-breaking scalar masses squared at the GUT scale for squarks and sleptons, [Formula: see text], as well as [Formula: see text]. The tension present in the CMSSM and NUHM1 between the supersymmetric interpretation of [Formula: see text] and the absence to date of SUSY at the LHC is not significantly alleviated in the NUHM2. We find that the minimum [Formula: see text] with 21 degrees of freedom (dof) in the NUHM2, to be compared with [Formula: see text] in the CMSSM, and [Formula: see text] in the NUHM1. We find that the one-dimensional likelihood functions for sparticle masses and other observables are similar to those found previously in the CMSSM and NUHM1.

  5. The NUHM2 after LHC Run 1

    DOE PAGES

    Buchmueller, O.; Cavanaugh, R.; Citron, M.; ...

    2014-12-17

    We make a frequentist analysis of the parameter space of the NUHM2, in which the soft supersymmetry (SUSY)-breaking contributions to the masses of the two Higgs multiplets, m2Hu,d, vary independently from the universal soft SUSY-breaking contributions m20 to the masses of squarks and sleptons. Our analysis uses the MultiNest sampling algorithm with over 4 × 10⁸ points to sample the NUHM2 parameter space. It includes the ATLAS and CMS Higgs mass measurements as well as the ATLAS search for supersymmetric jets + /ET signals using the full LHC Run 1 data, the measurements of BR(Bs→μ⁺μ⁻) by LHCb and CMS togethermore » with other B-physics observables, electroweak precision observables and the XENON100 and LUX searches for spin-independent dark-matter scattering. We find that the preferred regions of the NUHM2 parameter space have negative SUSY-breaking scalar masses squared at the GUT scale for squarks and sleptons, m20 < 0, as well as m2Hu < m2Hd < 0. The tension present in the CMSSM and NUHM1 between the supersymmetric interpretation of (g – 2)μ and the absence to date of SUSY at the LHC is not significantly alleviated in the NUHM2. We find that the minimum χ2 = 32.5 with 21 degrees of freedom (dof) in the NUHM2, to be compared with χ2/dof = 35.0/23 in the CMSSM, and χ2/dof = 32.7/22 in the NUHM1. We find that the one-dimensional likelihood functions for sparticle masses and other observables are similar to those found previously in the CMSSM and NUHM1.« less

  6. Selected experimental results from heavy-ion collisions at LHC

    DOE PAGES

    Singh, Ranbir; Kumar, Lokesh; Netrakanti, Pawan Kumar; ...

    2013-01-01

    We reviewmore » a subset of experimental results from the heavy-ion collisions at the Large Hadron Collider (LHC) facility at CERN. Excellent consistency is observed across all the experiments at the LHC (at center of mass energysNN=2.76 TeV) for the measurements such as charged particle multiplicity density, azimuthal anisotropy coefficients, and nuclear modification factor of charged hadrons. Comparison to similar measurements from the Relativistic Heavy Ion Collider (RHIC) at lower energy (sNN=200 GeV) suggests that the system formed at LHC has a higher energy density and larger system size and lives for a longer time. These measurements are compared to model calculations to obtain physical insights on the properties of matter created at the RHIC and LHC.« less

  7. Experimental overview on small collision systems at the LHC

    NASA Astrophysics Data System (ADS)

    Loizides, Constantin

    2016-12-01

    These conferences proceedings summarize the experimental findings obtained in small collision systems at the LHC, as presented in the special session on "QGP in small systems?" at the Quark Matter 2015 conference.

  8. Status of superconducting magnet development (SSC, RHIC, LHC)

    SciTech Connect

    Wanderer, P.

    1993-12-31

    This paper summarize recent superconducting accelerator magnet construction and test activities at the Superconducting Super Collider Laboratory (SSC), the Large Hadron Collider at CERN (LHC), and the Relativistic Heavy Ion Collider at Brookhaven (RHIC). Future plan are also presented.

  9. Operating the Worldwide LHC Computing Grid: current and future challenges

    NASA Astrophysics Data System (ADS)

    Flix Molina, J.; Forti, A.; Girone, M.; Sciaba, A.

    2014-06-01

    The Wordwide LHC Computing Grid project (WLCG) provides the computing and storage resources required by the LHC collaborations to store, process and analyse their data. It includes almost 200,000 CPU cores, 200 PB of disk storage and 200 PB of tape storage distributed among more than 150 sites. The WLCG operations team is responsible for several essential tasks, such as the coordination of testing and deployment of Grid middleware and services, communication with the experiments and the sites, followup and resolution of operational issues and medium/long term planning. In 2012 WLCG critically reviewed all operational procedures and restructured the organisation of the operations team as a more coherent effort in order to improve its efficiency. In this paper we describe how the new organisation works, its recent successes and the changes to be implemented during the long LHC shutdown in preparation for the LHC Run 2.

  10. Leptonic flavor violation in the Higgs sector at the LHC

    NASA Astrophysics Data System (ADS)

    McCoy, Brent; Kao, Chung; Hou, Wei-Shu; Kohda, Masaya; Soni, Amarjit

    2017-01-01

    We present the discovery potential of pp ->ϕ0 -> τμ + X at the Large Hadron Collider (LHC), with ϕ0 =h0 ,H0 ,A0 . We choose a general Two Higgs Doublet Model (2HDM) with non-negligible flavor changing couplings in the hadronic sector, in which ϕ0 couples to tc . Current data favors the alignment limit of a 2HDM where sin(β - α) 1 , which can enhance leptonic couplings to the light Higgs boson and might provide an observable flavor changing cross-section in that sector. We study the ϕ0 -> τμ channel for a range of cos(β - α) and ρτμ values that can be consistent with the CMS excess in Run-1 and account for dominant physics background with realistic acceptance cuts at √{ s} = 13 TeV and 14 TeV. U.S. Department of Energy and OU Supercomputing Center for Education and Research.

  11. Searches for hyperbolic extra dimensions at the LHC

    NASA Astrophysics Data System (ADS)

    Melbéus, Henrik; Ohlsson, Tommy

    2008-08-01

    We investigate a model of large extra dimensions where the internal space has the geometry of a hyperbolic disc. Compared with the ADD model, this model provides a more satisfactory solution to the hierarchy problem between the electroweak scale and the Planck scale, and it also avoids constraints from astrophysics. In general, a novel feature of this model is that the physical results depend on the position of the brane in the internal space, and in particular, the signal almost disappears completely if the brane is positioned at the center of the disc. Since there is no known analytic form of the Kaluza-Klein spectrum for our choice of geometry, we obtain a spectrum based on a combination of approximations and numerical computations. We study the possible signatures of our model for hadron colliders, especially the LHC, where the most important processes are the production of a graviton together with a hadronic jet or a photon. We find that the signals are similar to those of the ADD model, regarding both qualitative behavior and strength. For the case of hadronic jet production, it is possible to obtain relatively strong signals, while for the case of photon production, this is much more difficult.

  12. The Higgs and Supersymmetry at Run II of the LHC

    SciTech Connect

    Shih, David

    2016-04-14

    Prof. David Shih was supported by DOE grant DE-SC0013678 from April 2015 to April 2016. His research during this year focused on the phenomenology of super-symmetry (SUSY) and maximizing its future discovery potential at Run II of the LHC. SUSY is one of the most well-motivated frameworks for physics beyond the Standard Model. It solves the "naturalness" or "hierarchy" problem by stabilizing the Higgs mass against otherwise uncontrolled quantum corrections, predicts "grand unification" of the fundamental forces, and provides many potential candidates for dark matter. However, after decades of null results from direct and indirect searches, the viable parameter space for SUSY is increasingly constrained. Also, the discovery of a Standard Model-like Higgs with a mass at 125 GeV places a stringent constraint on SUSY models. In the work supported on this grant, Shih has worked on four different projects motivated by these issues. He has built natural SUSY models that explain the Higgs mass and provide viable dark matter; he has studied the parameter space of "gauge mediated supersymmetry breaking" (GMSB) that satisfies the Higgs mass constraint; he has developed new tools for the precision calculation of flavor and CP observables in general SUSY models; and he has studied new techniques for discovery of supersymmetric partners of the top quark.

  13. SUSY searches at the LHC with the ATLAS experiment

    ScienceCinema

    None

    2016-07-12

    First ATLAS searches for signals of Supersymmetry in proton-proton collisions at the LHC are presented. These searches are performed in various channels containing different lepton and jet multiplicities in the final states; the full data sample recorded in the 2010 LHC run, corresponding to an integrated luminosity of 35 pb-1, has been analysed. Limits on squarks and gluins are the most stringent to date.

  14. Black Holes at the LHC: Progress since 2002

    SciTech Connect

    Park, Seong Chan

    2008-11-23

    We review the recent noticeable progresses in black hole physics focusing on the up-coming super-collider, the LHC. We discuss the classical formation of black holes by particle collision, the greybody factors for higher dimensional rotating black holes, the deep implications of black hole physics to the 'energy-distance' relation, the security issues of the LHC associated with black hole formation and the newly developed Monte-Carlo generators for black hole events.

  15. Kruger 2010: Workshop on Discovery Physics at the LHC

    NASA Astrophysics Data System (ADS)

    Six days of plenary talks and parallel sessions where some of the very latest experimental results from the LHC (ALICE, ATLAS, CMS and LHCb), as well as topical beyond the Standard Model theories, will be presented. The surroundings of one of the world's largest national parks, and the physics results presented during this workshop, will serve to inspire discussions between theorists and experimentalists on the latest LHC and Tevatron measurements as well as our expectations for the future.

  16. CMS experiment at the LHC: Results and outlook

    NASA Astrophysics Data System (ADS)

    Golutvin, I. A.; Shmatov, S. V.

    2017-09-01

    The results of the CMS experiment based on the LHC first-run data taken at c.m.s. energies of 7 and 8 TeV and on the first data taken in the second-run at the c.m.s. energy of 13 TeV are presented. The research prospects with the LHC running at high luminosity are discussed.

  17. Upgrading Luminosity from the Tevatron Through the LHC

    NASA Astrophysics Data System (ADS)

    Peggs, Stephen

    2005-04-01

    Very soon the LHC will push the high energy frontier from 1 TeV to 7 TeV, well beyond present operating experience with the Tevatron. The LHC (with 2 rings) is also expected to raise proton luminosities by about two orders of magnitude, to about 10^34 cm-2sec-1 in its initial configuration. This extrapolation leads to a new regime of Accelerator Physics and Technology challenges. The stored energy in the nominal LHC beam is almost 3 orders of magnitude larger than in the Tevatron. Efficient acceleration up the energy ramp is more difficult and more important. Long range beam-beam collisions become more severe. Luminosity debris power becomes a significant constraint. The U.S. LHC Accelerator Research Program (LARP) is a collaboration of BNL, FNAL, LBNL, and SLAC, working with CERN to address these frontier issues. LARP is also working with CERN on an LHC Interaction Region upgrade, through which the luminosity may be increased even further, to about 10^35cm-2sec-1. This paper discusses the technical issues in extrapolating the energy and luminosity from the Tevatron to the LHC, and describes the programs in place to address them.

  18. Commissioning the cryogenic system of the first LHC sector

    SciTech Connect

    Millet, F.; Claudet, S.; Ferlin, G.; Perin, A.; Riddone, G.; Serio, L.; Soubiran, M.; Tavian, L.; Ronayette, L.; Rabehl, R.; /Fermilab

    2007-12-01

    The LHC machine, composed of eight sectors with superconducting magnets and accelerating cavities, requires a complex cryogenic system providing high cooling capacities (18 kW equivalent at 4.5 K and 2.4 W at 1.8 K per sector produced in large cold boxes and distributed via 3.3-km cryogenic transfer lines). After individual reception tests of the cryogenic subsystems (cryogen storages, refrigerators, cryogenic transfer lines and distribution boxes) performed since 2000, the commissioning of the cryogenic system of the first LHC sector has been under way since November 2006. After a brief introduction to the LHC cryogenic system and its specificities, the commissioning is reported detailing the preparation phase (pressure and leak tests, circuit conditioning and flushing), the cool-down sequences including the handling of cryogenic fluids, the magnet powering phase and finally the warm-up. Preliminary conclusions on the commissioning of the first LHC sector will be drawn with the review of the critical points already solved or still pending. The last part of the paper reports on the first operational experience of the LHC cryogenic system in the perspective of the commissioning of the remaining LHC sectors and the beam injection test.

  19. Will there be energy frontier colliders after LHC?

    SciTech Connect

    Shiltsev, Vladimir

    2016-09-15

    High energy particle colliders have been in the forefront of particle physics for more than three decades. At present the near term US, European and international strategies of the particle physics community are centered on full exploitation of the physics potential of the Large Hadron Collider (LHC) through its high-luminosity upgrade (HL-LHC). The future of the world-wide HEP community critically depends on the feasibility of possible post-LHC colliders. The concept of the feasibility is complex and includes at least three factors: feasibility of energy, feasibility of luminosity and feasibility of cost. Here we overview all current options for post-LHC colliders from such perspective (ILC, CLIC, Muon Collider, plasma colliders, CEPC, FCC, HE-LHC) and discuss major challenges and accelerator R&D required to demonstrate feasibility of an energy frontier accelerator facility following the LHC. We conclude by taking a look into ultimate energy reach accelerators based on plasmas and crystals, and discussion on the perspectives for the far future of the accelerator-based particle physics.

  20. The PDF4LHC report on PDFs and LHC data: Results from Run I and preparation for Run II

    SciTech Connect

    Rojo, Juan; Accardi, Alberto; Ball, Richard D.; Cooper-Sarkar, Amanda; de Roeck, Albert; Farry, Stephen; Ferrando, James; Forte, Stefano; Gao, Jun; Harland-Lang, Lucian; Huston, Joey; Glazov, Alexander; Gouzevitch, Maxime; Gwenlan, Claire; Lipka, Katerina; Lisovyi, Mykhailo; Mangano, Michelangelo; Nadolsky, Pavel; Perrozzi, Luca; Plačakytė, Ringaile; Radescu, Voica; Salam, Gavin P.; Thorne, Robert

    2015-09-16

    The accurate determination of Parton Distribution Functions (PDFs) of the proton is an essential ingredient of the Large Hadron Collider (LHC) program. PDF uncertainties impact a wide range of processes, from Higgs boson characterization and precision Standard Model measurements to New Physics searches. A major recent development in modern PDF analyses has been to exploit the wealth of new information contained in precision measurements from the LHC Run I, as well as progress in tools and methods to include these data in PDF fits. In this report we summarize the information that PDF-sensitive measurements at the LHC have provided so far, and review the prospects for further constraining PDFs with data from the recently started Run II. As a result, this document aims to provide useful input to the LHC collaborations to prioritize their PDF-sensitive measurements at Run II, as well as a comprehensive reference for the PDF-fitting collaborations.

  1. The PDF4LHC report on PDFs and LHC data: results from Run I and preparation for Run II

    NASA Astrophysics Data System (ADS)

    Rojo, Juan; Accardi, Alberto; Ball, Richard D.; Cooper-Sarkar, Amanda; de Roeck, Albert; Farry, Stephen; Ferrando, James; Forte, Stefano; Gao, Jun; Harland-Lang, Lucian; Huston, Joey; Glazov, Alexander; Gouzevitch, Maxime; Gwenlan, Claire; Lipka, Katerina; Lisovyi, Mykhailo; Mangano, Michelangelo; Nadolsky, Pavel; Perrozzi, Luca; Plačakytė, Ringaile; Radescu, Voica; Salam, Gavin P.; Thorne, Robert

    2015-10-01

    The accurate determination of the parton distribution functions (PDFs) of the proton is an essential ingredient of the Large Hadron Collider (LHC) program. PDF uncertainties impact a wide range of processes, from Higgs boson characterization and precision Standard Model measurements to new physics searches. A major recent development in modern PDF analyses has been to exploit the wealth of new information contained in precision measurements from the LHC Run I, as well as progress in tools and methods to include these data in PDF fits. In this report we summarize the information that PDF-sensitive measurements at the LHC have provided so far, and review the prospects for further constraining PDFs with data from the recently started Run II. This document aims to provide useful input to the LHC collaborations to prioritize their PDF-sensitive measurements at Run II, as well as a comprehensive reference for the PDF-fitting collaborations.

  2. The PDF4LHC report on PDFs and LHC data: Results from Run I and preparation for Run II

    DOE PAGES

    Rojo, Juan; Accardi, Alberto; Ball, Richard D.; ...

    2015-09-16

    The accurate determination of Parton Distribution Functions (PDFs) of the proton is an essential ingredient of the Large Hadron Collider (LHC) program. PDF uncertainties impact a wide range of processes, from Higgs boson characterization and precision Standard Model measurements to New Physics searches. A major recent development in modern PDF analyses has been to exploit the wealth of new information contained in precision measurements from the LHC Run I, as well as progress in tools and methods to include these data in PDF fits. In this report we summarize the information that PDF-sensitive measurements at the LHC have provided somore » far, and review the prospects for further constraining PDFs with data from the recently started Run II. As a result, this document aims to provide useful input to the LHC collaborations to prioritize their PDF-sensitive measurements at Run II, as well as a comprehensive reference for the PDF-fitting collaborations.« less

  3. Quench antenna studies of mechanical and quench performance in Fermilab interaction region quadrupoles for LHC

    SciTech Connect

    Tartaglia, M.A.; Feher, S.; Hocker, A.; Lamm, M.; Schlabach, P.; Sylvester, C.; Tompkins, J.C.; /Fermilab

    2005-09-01

    As part of the US-LHC collaboration, Fermilab has built and tested seventeen high gradient quadrupole magnets, assembled into nine cryostats, for installation at the Large Hadron Collider Interaction Regions. Most of these magnets have only quarter coil voltage taps for quench characterization, but the magnetic measurement warm bore is instrumented with a quench antenna for localization and characterization. We report on studies using the quench antenna for pre-production prototype (with extensive voltage taps) and 17 production magnets. These include a summary of quench localization and development characteristics, as well as general features of flux changes observed during training ramps.

  4. The NLO QCD corrections to associate production of squarks and charginos at LHC

    SciTech Connect

    Xiao Zhenjun; Jin Ligang; Yu Huan; Cheng Hongmei

    2010-02-10

    In this talk, we present our calculations for the next-to-leading order(NLO) QCD corrections to the cross sections (CS) of the associate production processes pp->gq->q-tilde{sub i}chi-tilde{sub j}{sup +}-+X with q = (u,d) in the constrained minimal supersymmetric standard model in the CERN LHC experiments. The NLO QCD corrections can in general provide a 30-40% enhancement to the corresponding cross sections, and significantly reduce the dependence of the total cross section on the renormalization and factorization scales.

  5. Examining the identity of Yukawa with gauge couplings in supersymmetric QCD at LHC

    SciTech Connect

    Freitas, Ayres; Skands, Peter Z.; Spira, M.; Zerwas, P.M.; /DESY

    2007-03-01

    The identity of the quark-squark-gluino Yukawa coupling with the corresponding quark-quark-gluon QCD coupling in supersymmetric theories can be examined experimentally at the Large Hadron Collider (LHC). Extending earlier investigations of like-sign di-lepton final states, we include jets in the analysis of the minimal supersymmetric standard model, adding squark-gluino and gluino-pair production to squark-pair production. Moreover we expand the method towards model-independent analyses which cover more general scenarios. In all cases, squark decays to light charginos and neutralinos persist to play a dominant role.

  6. The effect of LHC jet data on MSTW PDFs.

    PubMed

    Watt, B J A; Motylinski, P; Thorne, R S

    We consider the effect on LHC jet cross sections on partons distribution functions (PDFs), in particular the MSTW2008 set of PDFs. We first compare the published inclusive jet data to the predictions using MSTW2008, finding a very good description. We also use the parton distribution reweighting procedure to estimate the impact of these new data on the PDFs, finding that the combined ATLAS 2.76 and 7 TeV data, and CMS 7 TeV data have some significant impact. We then also investigate the impact of ATLAS, CMS and DØ dijet data using the same techniques. In this case we investigate the effect of using different scale choices for the NLO cross section calculation. We find that the dijet data is generally not completely compatible with the corresponding inclusive jet data, often tending to pull PDFs, particularly the gluon distribution, away from the default values. However, the effect depends on the dijet dataset used as well as the scale choice. We also note that conclusions may be affected by limiting the pull on the data luminosity chosen by the best fit, which is sometimes a number of standard deviations. Finally we include the inclusive jet data in a new PDF fit explicitly. This enables us to check the consistency of the exact result with that obtained from the reweighting procedure. There is generally good, but not full quantitative agreement. Hence, the conclusion remains that MSTW2008 PDFs already fit the published jet data well, but the central values and uncertainties are altered and improved, respectively, to a significant, but not dramatic extent by inclusion of these data.

  7. The LHCf experiment at the LHC accelerator

    SciTech Connect

    Bonechi, L.; Adriani, O.; Bongi, M.; D'Alessandro, R.; Papini, P.; Castellini, G.; Faus, A.; Velasco, J.; Haguenauer, M.; Itow, Y.; Mase, T.; Masuda, K.; Matsubara, Y.; Matsumoto, H.; Menjo, H.; Muraki, Y.; Sako, T.; Tanaka, K.; Watanabe, H.; Kasahara, K.

    2006-10-27

    The claimed discovery of atmospheric shower induced by cosmic-ray with energy beyond the GZK cutoff by the AGASA experiment in 1994-1995, although not confirmed by other important experiments like Fly's Eye and Hi-Res, together with the poor knowledge of the composition of cosmic rays around and beyond the Knee region, have highlighted the necessity of new experiments that should increase our present knowledge of HECR and UHECR. For this reason big efforts have been addressed to the development of new experiments, like Auger, TA and EUSO, for a systematic study of the UHE atmospheric showers with increased capabilities with respect to the previous experiments. Moreover complementary experiments should allow a precise calibration of the methods used for the reconstruction of cosmic-ray showers in atmosphere. Their aim is the measurement of quantities that are used in these procedures and that are not yet precisely known. Under this perspective the LHCf experiment is a compact experiment which has been proposed for the study of neutral pion and gamma production at high energy in proton-proton interaction in the very forward region of the LHC accelerator. It will help calibrating the algorithms that are used to reconstruct the atmospheric shower events for energy beyond the Knee. The LHCf apparatus and the results of the first beam test, held in 2004, are shortly discussed in this work.

  8. Precision diboson observables for the LHC

    NASA Astrophysics Data System (ADS)

    Frye, Christopher; Freytsis, Marat; Scholtz, Jakub; Strassler, Matthew J.

    2016-03-01

    Motivated by the restoration of SU(2) × U(1) at high energy, we suggest that certain ratios of diboson differential cross sections can be used as high-precision observables at the LHC. We rewrite leading-order diboson partonic cross sections in a form that makes their SU(2) × U(1) and custodial SU(2) structure more explicit than in previous literature, and identify important aspects of this structure that survive even in hadronic cross sections. We then focus on higher-order corrections to ratios of γγ, Zγ and ZZ processes, including full next-to-leading-order corrections and gg initial-state contributions, and argue that these ratios can likely be predicted to better than 5%, which should make them useful in searches for new phenomena. The ratio of Zγ to γγ is especially promising in the near term, due to large rates and to exceptional cancellations of QCD-related uncertainties. We argue that electroweak corrections are moderate in size, have small uncertainties, and can potentially be observed in these ratios in the long run.

  9. ψ(2S) Production at the LHC

    NASA Astrophysics Data System (ADS)

    Du, Xiaojian; Rapp, Ralf

    2017-01-01

    We calculate the production of ψ(2S) and the pertinent double ratio of its nuclear modi cation factor (R AA) over that of the J/ψ in Pb-Pb collisions at the LHC. Based on a transport model with temperature dependent reaction rates, a sequential regeneration pattern emerges: the larger ψ(2S) width, relative to the J/ψ, around and below the critical temperature, implies that most of the ψ(2S) states are regenerated later in the evolution of the reball. This has noticeable consequences for the transverse-momentum (pT ) spectra of the regenerated charmonia. While the total yield of ψ(2S) meson remains smaller than those of J/ψ’s, their harder pT spectra can produce a double ratio above unity for a pT > 3 GeV cut, as applied by the CMS collaboration. A signi cant uncertainty in our calculations is associated with the values of the temperature where most of the ψ(2S) regeneration occurs, i.e., the quantitative temperature dependence of its inelastic width.

  10. QCD, Tevatron results and LHC prospects

    SciTech Connect

    Elvira, V.Daniel; /Fermilab

    2008-08-01

    We present a summary of the most recent measurements relevant to Quantum Chromodynamics (QCD) delivered by the D0 and CDF Tevatron experiments by May 2008. CDF and D0 are moving toward precision measurements of QCD based on data samples in excess of 1 fb-1. The inclusive jet cross sections have been extended to forward rapidity regions and measured with unprecedented precision following improvements in the jet energy calibration. Results on dijet mass distributions, bbbar dijet production using tracker based triggers, underlying event in dijet and Drell-Yan samples, inclusive photon and diphoton cross sections complete the list of measurements included in this paper. Good agreement with pQCD within errors is observed for jet production measurements. An improved and consistent theoretical description is needed for photon+jets processes. Collisions at the LHC are scheduled for early fall 2008, opening an era of discoveries at the new energy frontier, 5-7 times higher than that of the Tevatron.

  11. Signatures of Spherical Compactifications at the LHC

    SciTech Connect

    Davoudiasl, Hooman; Rizzo, Thomas G.

    2007-02-12

    TeV-scale extra dimensions may play an important role in electroweak or supersymmetry breaking. We examine the phenomenology of such dimensions, compactified on a sphere S{sup n}, n {ge} 2, and show that they possess distinct features and signatures. For example, unlike flat toroidal manifolds, spheres do not trivially allow fermion massless modes. Acceptable phenomenology then generically leads to ''non-universal'' extra dimensions with ''pole-localized'' 4-d fermions; the bosonic fields can be in the bulk. Due to spherical symmetry, some Kaluza-Klein (KK) modes of bulk gauge fields are either stable or extremely long-lived, depending on the graviton KK spectrum. Using precision electroweak data, we constrain the lightest gauge field KK modes to lie above {approx_equal} 4 TeV. We show that some of these KK resonances are within the reach of the LHC in several different production channels. The models we study can be uniquely identified by their collider signatures.

  12. Using widgets to monitor the LHC experiments

    NASA Astrophysics Data System (ADS)

    González Caballero, I.; Sarkar, S.

    2011-12-01

    The complexity of the LHC experiments requires monitoring systems to verify the correct functioning of different sub-systems and to allow operators to quickly spot problems and issues that may cause loss of information and data. Due to the distributed nature of the collaborations and the different technologies involved, the information data that need to be correlated is usually spread over several databases, web pages and monitoring systems. On the other hand, although the complete set of monitorable aspects is known and fixed, the subset that each person needs to monitor is often different for each individual. Therefore, building a unique monitoring tool that suits every single collaborator becomes close to impossible. A modular approach with a set of customizable widgets, small autonomous portions of HTML and JavaScript, that can be aggregated to form private or public monitoring web pages can be a scalable and robust solution, where the information can be provided by a simple and thin set of web services. Among the different widget development toolkits available today, we have chosen the open project UWA (Unified Widget API) because of its portability to the most popular widget platforms (including iGoogle, Netvibes and Apple Dashboard). As an example, we show how this technology is currently being used to monitor parts of the CMS Computing project.

  13. Symmetry restored in dibosons at the LHC?

    SciTech Connect

    Brehmer, Johann; Hewett, JoAnne; Kopp, Joachim; Rizzo, Thomas; Tattersall, Jamie

    2015-10-28

    A number of LHC resonance search channels display an excess in the invariant mass region of 1.8–2.0 TeV. Among them is a 3.4σ excess in the fully hadronic decay of a pair of Standard Model electroweak gauge bosons, in addition to potential signals in the HW and dijet final states. We perform a model-independent cross-section fit to the results of all ATLAS and CMS searches sensitive to these final states. We then interpret these results in the context of the Left-Right Symmetric Model, based on the extended gauge group SU(2)L × SU(2)R × U(1)', and show that a heavy right-handed gauge boson WR can naturally explain the current measurements with just a single coupling gR ~ 0.4. Thus, we discuss a possible connection to dark matter.

  14. Fastlim: a fast LHC limit calculator

    NASA Astrophysics Data System (ADS)

    Papucci, Michele; Sakurai, Kazuki; Weiler, Andreas; Zeune, Lisa

    2014-11-01

    Fastlim is a tool to calculate conservative limits on extensions of the Standard Model from direct LHC searches without performing any Monte Carlo event generation. The program reconstructs the visible cross sections (cross sections after event selection cuts) from pre-calculated efficiency tables and cross section tables for simplified event topologies. As a proof of concept of the approach, we have implemented searches relevant for supersymmetric models with R-parity conservation. Fastlim takes the spectrum and coupling information of a given model point and provides, for each signal region of the implemented analyses, the visible cross sections normalised to the corresponding upper limit, reported by the experiments, as well as the value. To demonstrate the utility of the program we study the sensitivity of the recent ATLAS missing energy searches to the parameter space of natural SUSY models. The program structure allows the straightforward inclusion of external efficiency tables and can be generalised to R-parity violating scenarios and non-SUSY models. This paper serves as a self-contained user guide and indicates the conventions and approximations used.

  15. Cornering compressed gluino at the LHC

    NASA Astrophysics Data System (ADS)

    Nagata, Natsumi; Otono, Hidetoshi; Shirai, Satoshi

    2017-03-01

    We discuss collider search strategies of gluinos which are highly degenerate with the lightest neutralino in mass. This scenario is fairly difficult to probe with conventional search strategies at colliders, and thus may provide a hideaway of supersymmetry. Moreover, such a high degeneracy plays an important role in dark matter physics as the relic abundance of the lightest neutralino is significantly reduced via coannihilation. In this paper, we discuss ways of uncovering this scenario with the help of longevity of gluinos; if the mass difference between the lightest neutralino and gluino is ≲ 100 GeV and squarks are heavier than gluino, then the decay length of the gluino tends to be of the order of the detector-size scale. Such gluinos can be explored in the searches of displaced vertices, disappearing tracks, and anomalously large energy deposit by (meta)stable massive charged particles. We find that these searches are complementary to each other, and by combining their results we may probe a wide range of the compressed gluino region in the LHC experiments.

  16. Kaluza-Klein gravitons at LHC2

    NASA Astrophysics Data System (ADS)

    Dillon, Barry M.; Sanz, Veronica

    2017-08-01

    In this work we study constraints from new searches for heavy particles at the LHC on the allowed masses and couplings of a Kaluza-Klein (KK) graviton in a holographic composite Higgs model. Keeping new electroweak states heavy such that electroweak precision tests are satisfied, we control the mass of the lightest KK graviton using a brane kinetic term. With this we study KK graviton masses from 0.5-3 TeV. In our analysis we also employ little Randall-Sundrum (RS) models, characterized by a lower UV scale in the five-dimensional model which in turn implies modified couplings to massless bulk fields. Viewing this scenario as a strongly coupled four-dimensional theory with a composite Higgs boson, the KK graviton is interpreted as a composite spin-2 state and the varying UV scale corresponds to a varying intermediate scale between the cutoff of the low-energy effective theory and the Planck scale. We find that KK gravitons with masses in the range [500, 3000] GeV are compatible with current collider constraints, where the most promising channels for detecting these states are the diphoton and Z Z channels. A detection is more likely in the little RS models, in which the dual gauge theory has a larger number of colors than in traditional RS models.

  17. Calibration of Cryogenic Thermometers for the Lhc

    NASA Astrophysics Data System (ADS)

    Balle, Ch.; Casas-Cubillos, J.; Vauthier, N.; Thermeau, J. P.

    2008-03-01

    6000 cryogenic temperature sensors of resistive type covering the range from room temperature down to 1.6 K are installed on the LHC machine. In order to meet the stringent requirements on temperature control of the superconducting magnets, each single sensor needs to be calibrated individually. In the framework of a special contribution, IPN (Institut de Physique Nucléaire) in Orsay, France built and operated a calibration facility with a throughput of 80 thermometers per week. After reception from the manufacturer, the thermometer is first assembled onto a support specific to the measurement environment, and then thermally cycled ten times and calibrated at least once from 1.6 to 300 K. The procedure for each of these interventions includes various measurements and the acquired data is recorded in an ORACLE®-database. Furthermore random calibrations on some samples are executed at CERN to crosscheck the coherence between the approximation data obtained by both IPN and CERN. In the range of 1.5 K to 30 K, the calibration apparatuses at IPN and CERN are traceable to standards maintained in a national metrological laboratory by using a set of rhodium-iron temperature sensors of metrological quality. This paper presents the calibration procedure, the quality assurance applied, the results of the calibration campaigns and the return of experience.

  18. Fastlim: a fast LHC limit calculator.

    PubMed

    Papucci, Michele; Sakurai, Kazuki; Weiler, Andreas; Zeune, Lisa

    Fastlim is a tool to calculate conservative limits on extensions of the Standard Model from direct LHC searches without performing any Monte Carlo event generation. The program reconstructs the visible cross sections (cross sections after event selection cuts) from pre-calculated efficiency tables and cross section tables for simplified event topologies. As a proof of concept of the approach, we have implemented searches relevant for supersymmetric models with R-parity conservation. Fastlim takes the spectrum and coupling information of a given model point and provides, for each signal region of the implemented analyses, the visible cross sections normalised to the corresponding upper limit, reported by the experiments, as well as the [Formula: see text] value. To demonstrate the utility of the program we study the sensitivity of the recent ATLAS missing energy searches to the parameter space of natural SUSY models. The program structure allows the straightforward inclusion of external efficiency tables and can be generalised to R-parity violating scenarios and non-SUSY models. This paper serves as a self-contained user guide and indicates the conventions and approximations used.

  19. Models of Black Hole Production at LHC

    NASA Astrophysics Data System (ADS)

    Klippert, R.; Salinas, C. J. Solano

    2002-10-01

    The purpose of this paper is to discuss about the different models for black hole production at the future Large Hadron Collider. In traditional scenarios the Planck scale is fundamental, and the weak scale is derived from it via some dynamical mechanism. Recently, several authors are exploring an alternative viewpoint where the weak scale is the fundamental scale of nature and the 4-dimensional Planck scale is to be derived from that 1. These scenarios include large or warped extra dimensions, propagation of matter and gauge degrees of freedom on brane worlds, and a fundamental Planck scale of O(TeV). If the scale of quantum gravity is near TeV we will have a copious production of mini black holes at the Large Hadron Collider 2 and Cosmic rays interactions in the atmosphere 3. We discussed as well other line of semi-classical models from analog gravity in nonlinear electrodynamics that can be tested as well at LHC. The possibles consequences of these models for high energy experimental physics are discussed.

  20. Family gauge boson production at the LHC

    NASA Astrophysics Data System (ADS)

    Koide, Yoshio; Yamanaka, Masato; Yokoya, Hiroshi

    2015-11-01

    Family gauge boson production at the LHC is investigated according to a U (3) family gauge model with twisted family number assignment. In the model we study, a family gauge boson with the lowest mass, A11, interacts only with the first generation leptons and the third generation quarks. (The family numbers are assigned, for example, as (e1 ,e2 ,e3) = (e- ,μ- ,τ-) and (d1 ,d2 ,d3) = (b , d , s) [or (d1 ,d2 ,d3) = (b , s , d)].) In the model, the family gauge coupling constant is fixed by relating to the electroweak gauge coupling constant. Thus measurements of production cross sections and branching ratios of A11 clearly confirm or rule out the model. We calculate the cross sections of inclusive A11 production and b b bar (t t bar) associated A11 production at √{ s} = 14 TeV and 100 TeV. With the dielectron production cross section, we discuss the determination of diagonalizing matrix of quark mass matrix, Uu and Ud, respectively.

  1. Bottomia physics at RHIC and LHC

    NASA Astrophysics Data System (ADS)

    Wolschin, Georg

    2017-04-01

    In UU collisions at RHIC energies and PbPb collisions at LHC energies the suppression of ϒ mesons in the hot quark-gluon medium (QGP) versus reduced feed-down is investigated. Our model encompasses screening, collisional damping and gluodissociation in the QGP. For ϒ(1S) it is in agreement with both STAR and CMS data provided the relativistic Doppler effect and the reduced feed-down from the ϒ(nS) and χb(nP) states are properly considered. At both energies, most of the suppression for the ϒ(1S) state is found to be due to reduced feed-down, whereas most of the ϒ(2S) suppression is caused by the hot-medium effects. The role of the in-medium effects relative to reduced feed-down in creases with energy. The ϒ(1S)-suppression in PbPb at √sNN = 5.02 TeV is predicted.

  2. The CMS experiment at the CERN LHC

    NASA Astrophysics Data System (ADS)

    CMS Collaboration; Chatrchyan, S.; Hmayakyan, G.; Khachatryan, V.; Sirunyan, A. M.; Adam, W.; Bauer, T.; Bergauer, T.; Bergauer, H.; Dragicevic, M.; Erö, J.; Friedl, M.; Frühwirth, R.; Ghete, V. M.; Glaser, P.; Hartl, C.; Hoermann, N.; Hrubec, J.; Hänsel, S.; Jeitler, M.; Kastner, K.; Krammer, M.; Magrans de Abril, I.; Markytan, M.; Mikulec, I.; Neuherz, B.; Nöbauer, T.; Oberegger, M.; Padrta, M.; Pernicka, M.; Porth, P.; Rohringer, H.; Schmid, S.; Schreiner, T.; Stark, R.; Steininger, H.; Strauss, J.; Taurok, A.; Uhl, D.; Waltenberger, W.; Walzel, G.; Widl, E.; Wulz, C.-E.; Petrov, V.; Prosolovich, V.; Chekhovsky, V.; Dvornikov, O.; Emeliantchik, I.; Litomin, A.; Makarenko, V.; Marfin, I.; Mossolov, V.; Shumeiko, N.; Solin, A.; Stefanovitch, R.; Suarez Gonzalez, J.; Tikhonov, A.; Fedorov, A.; Korzhik, M.; Missevitch, O.; Zuyeuski, R.; Beaumont, W.; Cardaci, M.; DeLanghe, E.; DeWolf, E. A.; Delmeire, E.; Ochesanu, S.; Tasevsky, M.; Van Mechelen, P.; D'Hondt, J.; DeWeirdt, S.; Devroede, O.; Goorens, R.; Hannaert, S.; Heyninck, J.; Maes, J.; Mozer, M. U.; Tavernier, S.; Van Doninck, W.; Van Lancker, L.; Van Mulders, P.; Villella, I.; Wastiels, C.; Yu, C.; Bouhali, O.; Charaf, O.; Clerbaux, B.; DeHarenne, P.; DeLentdecker, G.; Dewulf, J. P.; Elgammal, S.; Gindroz, R.; Hammad, G. H.; Mahmoud, T.; Neukermans, L.; Pins, M.; Pins, R.; Rugovac, S.; Stefanescu, J.; Sundararajan, V.; Vander Velde, C.; Vanlaer, P.; Wickens, J.; Tytgat, M.; Assouak, S.; Bonnet, J. L.; Bruno, G.; Caudron, J.; DeCallatay, B.; DeFavereau DeJeneret, J.; DeVisscher, S.; Demin, P.; Favart, D.; Felix, C.; Florins, B.; Forton, E.; Giammanco, A.; Grégoire, G.; Jonckman, M.; Kcira, D.; Keutgen, T.; Lemaitre, V.; Michotte, D.; Militaru, O.; Ovyn, S.; Pierzchala, T.; Piotrzkowski, K.; Roberfroid, V.; Rouby, X.; Schul, N.; Van der Aa, O.; Beliy, N.; Daubie, E.; Herquet, P.; Alves, G.; Pol, M. E.; Souza, M. H. G.; Vaz, M.; DeJesus Damiao, D.; Oguri, V.; Santoro, A.; Sznajder, A.; DeMoraes Gregores, E.; Iope, R. L.; Novaes, S. F.; Tomei, T.; Anguelov, T.; Antchev, G.; Atanasov, I.; Damgov, J.; Darmenov, N.; Dimitrov, L.; Genchev, V.; Iaydjiev, P.; Marinov, A.; Piperov, S.; Stoykova, S.; Sultanov, G.; Trayanov, R.; Vankov, I.; Cheshkov, C.; Dimitrov, A.; Dyulendarova, M.; Glushkov, I.; Kozhuharov, V.; Litov, L.; Makariev, M.; Marinova, E.; Markov, S.; Mateev, M.; Nasteva, I.; Pavlov, B.; Petev, P.; Petkov, P.; Spassov, V.; Toteva, Z.; Velev, V.; Verguilov, V.; Bian, J. G.; Chen, G. M.; Chen, H. S.; Chen, M.; Jiang, C. H.; Liu, B.; Shen, X. Y.; Sun, H. S.; Tao, J.; Wang, J.; Yang, M.; Zhang, Z.; Zhao, W. R.; Zhuang, H. L.; Ban, Y.; Cai, J.; Ge, Y. C.; Liu, S.; Liu, H. T.; Liu, L.; Qian, S. J.; Wang, Q.; Xue, Z. H.; Yang, Z. C.; Ye, Y. L.; Ying, J.; Li, P. J.; Liao, J.; Xue, Z. L.; Yan, D. S.; Yuan, H.; Carrillo Montoya, C. A.; Sanabria, J. C.; Godinovic, N.; Puljak, I.; Soric, I.; Antunovic, Z.; Dzelalija, M.; Marasovic, K.; Brigljevic, V.; Kadija, K.; Morovic, S.; Fereos, R.; Nicolaou, C.; Papadakis, A.; Ptochos, F.; Razis, P. A.; Tsiakkouri, D.; Zinonos, Z.; Hektor, A.; Kadastik, M.; Kannike, K.; Lippmaa, E.; Müntel, M.; Raidal, M.; Rebane, L.; Aarnio, P. A.; Anttila, E.; Banzuzi, K.; Bulteau, P.; Czellar, S.; Eiden, N.; Eklund, C.; Engstrom, P.; Heikkinen, A.; Honkanen, A.; Härkönen, J.; Karimäki, V.; Katajisto, H. M.; Kinnunen, R.; Klem, J.; Kortesmaa, J.; Kotamäki, M.; Kuronen, A.; Lampén, T.; Lassila-Perini, K.; Lefébure, V.; Lehti, S.; Lindén, T.; Luukka, P. R.; Michal, S.; Moura Brigido, F.; Mäenpää, T.; Nyman, T.; Nystén, J.; Pietarinen, E.; Skog, K.; Tammi, K.; Tuominen, E.; Tuominiemi, J.; Ungaro, D.; Vanhala, T. P.; Wendland, L.; Williams, C.; Iskanius, M.; Korpela, A.; Polese, G.; Tuuva, T.; Bassompierre, G.; Bazan, A.; David, P. Y.; Ditta, J.; Drobychev, G.; Fouque, N.; Guillaud, J. P.; Hermel, V.; Karneyeu, A.; LeFlour, T.; Lieunard, S.; Maire, M.; Mendiburu, P.; Nedelec, P.; Peigneux, J. P.; Schneegans, M.; Sillou, D.; Vialle, J. P.; Anfreville, M.; Bard, J. P.; Besson, P.; Bougamont, E.; Boyer, M.; Bredy, P.; Chipaux, R.; Dejardin, M.; Denegri, D.; Descamps, J.; Fabbro, B.; Faure, J. L.; Ganjour, S.; Gentit, F. X.; Givernaud, A.; Gras, P.; Hamel de Monchenault, G.; Jarry, P.; Jeanney, C.; Kircher, F.; Lemaire, M. C.; Lemoigne, Y.; Levesy, B.; Locci, E.; Lottin, J. P.; Mandjavidze, I.; Mur, M.; Pansart, J. P.; Payn, A.; Rander, J.; Reymond, J. M.; Rolquin, J.; Rondeaux, F.; Rosowsky, A.; Rousse, J. Y. A.; Sun, Z. H.; Tartas, J.; Van Lysebetten, A.; Venault, P.; Verrecchia, P.; Anduze, M.; Badier, J.; Baffioni, S.; Bercher, M.; Bernet, C.; Berthon, U.; Bourotte, J.; Busata, A.; Busson, P.; Cerutti, M.; Chamont, D.; Charlot, C.; Collard, C.; Debraine, A.; Decotigny, D.; Dobrzynski, L.; Ferreira, O.; Geerebaert, Y.; Gilly, J.; Gregory, C.; Guevara Riveros, L.; Haguenauer, M.; Karar, A.; Koblitz, B.; Lecouturier, D.; Mathieu, A.; Milleret, G.; Miné, P.; Paganini, P.; Poilleux, P.; Pukhaeva, N.; Regnault, N.; Romanteau, T.; Semeniouk, I.; Sirois, Y.; Thiebaux, C.; Vanel, J. C.; Zabi, A.; Agram, J. L.; Albert, A.; Anckenmann, L.; Andrea, J.; Anstotz, F.; Bergdolt, A. M.; Berst, J. D.; Blaes, R.; Bloch, D.; Brom, J. M.; Cailleret, J.; Charles, F.; Christophel, E.; Claus, G.; Coffin, J.; Colledani, C.; Croix, J.; Dangelser, E.; Dick, N.; Didierjean, F.; Drouhin, F.; Dulinski, W.; Ernenwein, J. P.; Fang, R.; Fontaine, J. C.; Gaudiot, G.; Geist, W.; Gelé, D.; Goeltzenlichter, T.; Goerlach, U.; Graehling, P.; Gross, L.; Hu, C. Guo; Helleboid, J. M.; Henkes, T.; Hoffer, M.; Hoffmann, C.; Hosselet, J.; Houchu, L.; Hu, Y.; Huss, D.; Illinger, C.; Jeanneau, F.; Juillot, P.; Kachelhoffer, T.; Kapp, M. R.; Kettunen, H.; Lakehal Ayat, L.; LeBihan, A. C.; Lounis, A.; Maazouzi, C.; Mack, V.; Majewski, P.; Mangeol, D.; Michel, J.; Moreau, S.; Olivetto, C.; Pallarès, A.; Patois, Y.; Pralavorio, P.; Racca, C.; Riahi, Y.; Ripp-Baudot, I.; Schmitt, P.; Schunck, J. P.; Schuster, G.; Schwaller, B.; Sigward, M. H.; Sohler, J. L.; Speck, J.; Strub, R.; Todorov, T.; Turchetta, R.; Van Hove, P.; Vintache, D.; Zghiche, A.; Ageron, M.; Augustin, J. E.; Baty, C.; Baulieu, G.; Bedjidian, M.; Blaha, J.; Bonnevaux, A.; Boudoul, G.; Brunet, P.; Chabanat, E.; Chabert, E. C.; Chierici, R.; Chorowicz, V.; Combaret, C.; Contardo, D.; Della Negra, R.; Depasse, P.; Drapier, O.; Dupanloup, M.; Dupasquier, T.; El Mamouni, H.; Estre, N.; Fay, J.; Gascon, S.; Giraud, N.; Girerd, C.; Guillot, G.; Haroutunian, R.; Ille, B.; Lethuillier, M.; Lumb, N.; Martin, C.; Mathez, H.; Maurelli, G.; Muanza, S.; Pangaud, P.; Perries, S.; Ravat, O.; Schibler, E.; Schirra, F.; Smadja, G.; Tissot, S.; Trocme, B.; Vanzetto, S.; Walder, J. P.; Bagaturia, Y.; Mjavia, D.; Mzhavia, A.; Tsamalaidze, Z.; Roinishvili, V.; Adolphi, R.; Anagnostou, G.; Brauer, R.; Braunschweig, W.; Esser, H.; Feld, L.; Karpinski, W.; Khomich, A.; Klein, K.; Kukulies, C.; Lübelsmeyer, K.; Olzem, J.; Ostaptchouk, A.; Pandoulas, D.; Pierschel, G.; Raupach, F.; Schael, S.; Schultz von Dratzig, A.; Schwering, G.; Siedling, R.; Thomas, M.; Weber, M.; Wittmer, B.; Wlochal, M.; Adamczyk, F.; Adolf, A.; Altenhöfer, G.; Bechstein, S.; Bethke, S.; Biallass, P.; Biebel, O.; Bontenackels, M.; Bosseler, K.; Böhm, A.; Erdmann, M.; Faissner, H.; Fehr, B.; Fesefeldt, H.; Fetchenhauer, G.; Frangenheim, J.; Frohn, J. H.; Grooten, J.; Hebbeker, T.; Hermann, S.; Hermens, E.; Hilgers, G.; Hoepfner, K.; Hof, C.; Jacobi, E.; Kappler, S.; Kirsch, M.; Kreuzer, P.; Kupper, R.; Lampe, H. R.; Lanske, D.; Mameghani, R.; Meyer, A.; Meyer, S.; Moers, T.; Müller, E.; Pahlke, R.; Philipps, B.; Rein, D.; Reithler, H.; Reuter, W.; Rütten, P.; Schulz, S.; Schwarthoff, H.; Sobek, W.; Sowa, M.; Stapelberg, T.; Szczesny, H.; Teykal, H.; Teyssier, D.; Tomme, H.; Tomme, W.; Tonutti, M.; Tsigenov, O.; Tutas, J.; Vandenhirtz, J.; Wagner, H.; Wegner, M.; Zeidler, C.; Beissel, F.; Davids, M.; Duda, M.; Flügge, G.; Giffels, M.; Hermanns, T.; Heydhausen, D.; Kalinin, S.; Kasselmann, S.; Kaussen, G.; Kress, T.; Linn, A.; Nowack, A.; Perchalla, L.; Poettgens, M.; Pooth, O.; Sauerland, P.; Stahl, A.; Tornier, D.; Zoeller, M. H.; Behrens, U.; Borras, K.; Flossdorf, A.; Hatton, D.; Hegner, B.; Kasemann, M.; Mankel, R.; Meyer, A.; Mnich, J.; Rosemann, C.; Youngman, C.; Zeuner, W. D.; Bechtel, F.; Buhmann, P.; Butz, E.; Flucke, G.; Hamdorf, R. H.; Holm, U.; Klanner, R.; Pein, U.; Schirm, N.; Schleper, P.; Steinbrück, G.; Van Staa, R.; Wolf, R.; Atz, B.; Barvich, T.; Blüm, P.; Boegelspacher, F.; Bol, H.; Chen, Z. Y.; Chowdhury, S.; DeBoer, W.; Dehm, P.; Dirkes, G.; Fahrer, M.; Felzmann, U.; Frey, M.; Furgeri, A.; Gregoriev, E.; Hartmann, F.; Hauler, F.; Heier, S.; Kärcher, K.; Ledermann, B.; Mueller, S.; Müller, Th; Neuberger, D.; Piasecki, C.; Quast, G.; Rabbertz, K.; Sabellek, A.; Scheurer, A.; Schilling, F. P.; Simonis, H. J.; Skiba, A.; Steck, P.; Theel, A.; Thümmel, W. H.; Trunov, A.; Vest, A.; Weiler, T.; Weiser, C.; Weseler, S.; Zhukov, V.; Barone, M.; Daskalakis, G.; Dimitriou, N.; Fanourakis, G.; Filippidis, C.; Geralis, T.; Kalfas, C.; Karafasoulis, K.; Koimas, A.; Kyriakis, A.; Kyriazopoulou, S.; Loukas, D.; Markou, A.; Markou, C.; Mastroyiannopoulos, N.; Mavrommatis, C.; Mousa, J.; Papadakis, I.; Petrakou, E.; Siotis, I.; Theofilatos, K.; Tzamarias, S.; Vayaki, A.; Vermisoglou, G.; Zachariadou, A.; Gouskos, L.; Karapostoli, G.; Katsas, P.; Panagiotou, A.; Papadimitropoulos, C.; Aslanoglou, X.; Evangelou, I.; Kokkas, P.; Manthos, N.; Papadopoulos, I.; Triantis, F. A.; Bencze, G.; Boldizsar, L.; Debreczeni, G.; Hajdu, C.; Hidas, P.; Horvath, D.; Kovesarki, P.; Laszlo, A.; Odor, G.; Patay, G.; Sikler, F.; Veres, G.; Vesztergombi, G.; Zalan, P.; Fenyvesi, A.; Imrek, J.; Molnar, J.; Novak, D.; Palinkas, J.; Szekely, G.; Beni, N.; Kapusi, A.; Marian, G.; Radics, B.; Raics, P.; Szabo, Z.; Szillasi, Z.; Trocsanyi, Z. L.; Zilizi, G.; Bawa, H. S.; Beri, S. B.; Bhandari, V.; Bhatnagar, V.; Kaur, M.; Kohli, J. M.; Kumar, A.; Singh, B.; Singh, J. B.; Arora, S.; Bhattacharya, S.; Chatterji, S.; Chauhan, S.; Choudhary, B. C.; Gupta, P.; Jha, M.; Ranjan, K.; Shivpuri, R. K.; Srivastava, A. K.; Choudhury, R. K.; Dutta, D.; Ghodgaonkar, M.; Kailas, S.; Kataria, S. K.; Mohanty, A. K.; Pant, L. M.; Shukla, P.; Topkar, A.; Aziz, T.; Banerjee, Sunanda; Bose, S.; Chendvankar, S.; Deshpande, P. V.; Guchait, M.; Gurtu, A.; Maity, M.; Majumder, G.; Mazumdar, K.; Nayak, A.; Patil, M. R.; Sharma, S.; Sudhakar, K.; Acharya, B. S.; Banerjee, Sudeshna; Bheesette, S.; Dugad, S.; Kalmani, S. D.; Lakkireddi, V. R.; Mondal, N. K.; Panyam, N.; Verma, P.; Arfaei, H.; Hashemi, M.; Najafabadi, M. Mohammadi; Moshaii, A.; Paktinat Mehdiabadi, S.; Felcini, M.; Grunewald, M.; Abadjiev, K.; Abbrescia, M.; Barbone, L.; Cariola, P.; Chiumarulo, F.; Clemente, A.; Colaleo, A.; Creanza, D.; DeFilippis, N.; DePalma, M.; DeRobertis, G.; Donvito, G.; Ferorelli, R.; Fiore, L.; Franco, M.; Giordano, D.; Guida, R.; Iaselli, G.; Lacalamita, N.; Loddo, F.; Maggi, G.; Maggi, M.; Manna, N.; Marangelli, B.; Mennea, M. S.; My, S.; Natali, S.; Nuzzo, S.; Papagni, G.; Pinto, C.; Pompili, A.; Pugliese, G.; Ranieri, A.; Romano, F.; Roselli, G.; Sala, G.; Selvaggi, G.; Silvestris, L.; Tempesta, P.; Trentadue, R.; Tupputi, S.; Zito, G.; Abbiendi, G.; Bacchi, W.; Battilana, C.; Benvenuti, A. C.; Boldini, M.; Bonacorsi, D.; Braibant-Giacomelli, S.; Cafaro, V. D.; Capiluppi, P.; Castro, A.; Cavallo, F. R.; Ciocca, C.; Codispoti, G.; Cuffiani, M.; D'Antone, I.; Dallavalle, G. M.; Fabbri, F.; Fanfani, A.; Finelli, S.; Giacomelli, P.; Giordano, V.; Giunta, M.; Grandi, C.; Guerzoni, M.; Guiducci, L.; Marcellini, S.; Masetti, G.; Montanari, A.; Navarria, F. L.; Odorici, F.; Paolucci, A.; Pellegrini, G.; Perrotta, A.; Rossi, A. M.; Rovelli, T.; Siroli, G. P.; Torromeo, G.; Travaglini, R.; Veronese, G. P.; Albergo, S.; Chiorboli, M.; Costa, S.; Galanti, M.; Gatto Rotondo, G.; Giudice, N.; Guardone, N.; Noto, F.; Potenza, R.; Saizu, M. A.; Salemi, G.; Sutera, C.; Tricomi, A.; Tuve, C.; Bellucci, L.; Brianzi, M.; Broccolo, G.; Catacchini, E.; Ciulli, V.; Civinini, C.; D'Alessandro, R.; Focardi, E.; Frosali, S.; Genta, C.; Landi, G.; Lenzi, P.; Macchiolo, A.; Maletta, F.; Manolescu, F.; Marchettini, C.; Masetti, L.; Mersi, S.; Meschini, M.; Minelli, C.; Paoletti, S.; Parrini, G.; Scarlini, E.; Sguazzoni, G.; Benussi, L.; Bertani, M.; Bianco, S.; Caponero, M.; Colonna, D.; Daniello, L.; Fabbri, F.; Felli, F.; Giardoni, M.; La Monaca, A.; Ortenzi, B.; Pallotta, M.; Paolozzi, A.; Paris, C.; Passamonti, L.; Pierluigi, D.; Ponzio, B.; Pucci, C.; Russo, A.; Saviano, G.; Fabbricatore, P.; Farinon, S.; Greco, M.; Musenich, R.; Badoer, S.; Berti, L.; Biasotto, M.; Fantinel, S.; Frizziero, E.; Gastaldi, U.; Gulmini, M.; Lelli, F.; Maron, G.; Squizzato, S.; Toniolo, N.; Traldi, S.; Banfi, S.; Bertoni, R.; Bonesini, M.; Carbone, L.; Cerati, G. B.; Chignoli, F.; D'Angelo, P.; DeMin, A.; Dini, P.; Farina, F. M.; Ferri, F.; Govoni, P.; Magni, S.; Malberti, M.; Malvezzi, S.; Mazza, R.; Menasce, D.; Miccio, V.; Moroni, L.; Negri, P.; Paganoni, M.; Pedrini, D.; Pullia, A.; Ragazzi, S.; Redaelli, N.; Rovere, M.; Sala, L.; Sala, S.; Salerno, R.; Tabarelli de Fatis, T.; Tancini, V.; Taroni, S.; Boiano, A.; Cassese, F.; Cassese, C.; Cimmino, A.; D'Aquino, B.; Lista, L.; Lomidze, D.; Noli, P.; Paolucci, P.; Passeggio, G.; Piccolo, D.; Roscilli, L.; Sciacca, C.; Vanzanella, A.; Azzi, P.; Bacchetta, N.; Barcellan, L.; Bellato, M.; Benettoni, M.; Bisello, D.; Borsato, E.; Candelori, A.; Carlin, R.; Castellani, L.; Checchia, P.; Ciano, L.; Colombo, A.; Conti, E.; Da Rold, M.; Dal Corso, F.; DeGiorgi, M.; DeMattia, M.; Dorigo, T.; Dosselli, U.; Fanin, C.; Galet, G.; Gasparini, F.; Gasparini, U.; Giraldo, A.; Giubilato, P.; Gonella, F.; Gresele, A.; Griggio, A.; Guaita, P.; Kaminskiy, A.; Karaevskii, S.; Khomenkov, V.; Kostylev, D.; Lacaprara, S.; Lazzizzera, I.; Lippi, I.; Loreti, M.; Margoni, M.; Martinelli, R.; Mattiazzo, S.; Mazzucato, M.; Meneguzzo, A. T.; Modenese, L.; Montecassiano, F.; Neviani, A.; Nigro, M.; Paccagnella, A.; Pantano, D.; Parenti, A.; Passaseo, M.; Pedrotta, R.; Pegoraro, M.; Rampazzo, G.; Reznikov, S.; Ronchese, P.; Sancho Daponte, A.; Sartori, P.; Stavitskiy, I.; Tessaro, M.; Torassa, E.; Triossi, A.; Vanini, S.; Ventura, S.; Ventura, L.; Verlato, M.; Zago, M.; Zatti, F.; Zotto, P.; Zumerle, G.; Baesso, P.; Belli, G.; Berzano, U.; Bricola, S.; Grelli, A.; Musitelli, G.; Nardò, R.; Necchi, M. M.; Pagano, D.; Ratti, S. P.; Riccardi, C.; Torre, P.; Vicini, A.; Vitulo, P.; Viviani, C.; Aisa, D.; Aisa, S.; Ambroglini, F.; Angarano, M. M.; Babucci, E.; Benedetti, D.; Biasini, M.; Bilei, G. M.; Bizzaglia, S.; Brunetti, M. T.; Caponeri, B.; Checcucci, B.; Covarelli, R.; Dinu, N.; Fanò, L.; Farnesini, L.; Giorgi, M.; Lariccia, P.; Mantovani, G.; Moscatelli, F.; Passeri, D.; Piluso, A.; Placidi, P.; Postolache, V.; Santinelli, R.; Santocchia, A.; Servoli, L.; Spiga, D.; Azzurri, P.; Bagliesi, G.; Balestri, G.; Basti, A.; Bellazzini, R.; Benucci, L.; Bernardini, J.; Berretta, L.; Bianucci, S.; Boccali, T.; Bocci, A.; Borrello, L.; Bosi, F.; Bracci, F.; Brez, A.; Calzolari, F.; Castaldi, R.; Cazzola, U.; Ceccanti, M.; Cecchi, R.; Cerri, C.; Cucoanes, A. S.; Dell'Orso, R.; Dobur, D.; Dutta, S.; Fiori, F.; Foà, L.; Gaggelli, A.; Gennai, S.; Giassi, A.; Giusti, S.; Kartashov, D.; Kraan, A.; Latronico, L.; Ligabue, F.; Linari, S.; Lomtadze, T.; Lungu, G. A.; Magazzu, G.; Mammini, P.; Mariani, F.; Martinelli, G.; Massa, M.; Messineo, A.; Moggi, A.; Palla, F.; Palmonari, F.; Petragnani, G.; Petrucciani, G.; Profeti, A.; Raffaelli, F.; Rizzi, D.; Sanguinetti, G.; Sarkar, S.; Segneri, G.; Sentenac, D.; Serban, A. T.; Slav, A.; Spagnolo, P.; Spandre, G.; Tenchini, R.; Tolaini, S.; Tonelli, G.; Venturi, A.; Verdini, P. G.; Vos, M.; Zaccarelli, L.; Baccaro, S.; Barone, L.; Bartoloni, A.; Borgia, B.; Capradossi, G.; Cavallari, F.; Cecilia, A.; D'Angelo, D.; Dafinei, I.; DelRe, D.; Di Marco, E.; Diemoz, M.; Ferrara, G.; Gargiulo, C.; Guerra, S.; Iannone, M.; Longo, E.; Montecchi, M.; Nuccetelli, M.; Organtini, G.; Palma, A.; Paramatti, R.; Pellegrino, F.; Rahatlou, S.; Rovelli, C.; Safai Tehrani, F.; Zullo, A.; Alampi, G.; Amapane, N.; Arcidiacono, R.; Argiro, S.; Arneodo, M.; Bellan, R.; Benotto, F.; Biino, C.; Bolognesi, S.; Borgia, M. A.; Botta, C.; Brasolin, A.; Cartiglia, N.; Castello, R.; Cerminara, G.; Cirio, R.; Cordero, M.; Costa, M.; Dattola, D.; Daudo, F.; Dellacasa, G.; Demaria, N.; Dughera, G.; Dumitrache, F.; Farano, R.; Ferrero, G.; Filoni, E.; Kostyleva, G.; Larsen, H. E.; Mariotti, C.; Marone, M.; Maselli, S.; Menichetti, E.; Mereu, P.; Migliore, E.; Mila, G.; Monaco, V.; Musich, M.; Nervo, M.; Obertino, M. M.; Panero, R.; Parussa, A.; Pastrone, N.; Peroni, C.; Petrillo, G.; Romero, A.; Ruspa, M.; Sacchi, R.; Scalise, M.; Solano, A.; Staiano, A.; Trapani, P. P.; Trocino, D.; Vaniev, V.; Vilela Pereira, A.; Zampieri, A.; Belforte, S.; Cossutti, F.; Della Ricca, G.; Gobbo, B.; Kavka, C.; Penzo, A.; Kim, Y. E.; Nam, S. K.; Kim, D. H.; Kim, G. N.; Kim, J. C.; Kong, D. J.; Ro, S. R.; Son, D. C.; Park, S. Y.; Kim, Y. J.; Kim, J. Y.; Lim, I. T.; Pac, M. Y.; Lee, S. J.; Jung, S. Y.; Rhee, J. T.; Ahn, S. H.; Hong, B. S.; Jeng, Y. K.; Kang, M. H.; Kim, H. C.; Kim, J. H.; Kim, T. J.; Lee, K. S.; Lim, J. K.; Moon, D. H.; Park, I. C.; Park, S. K.; Ryu, M. S.; Sim, K.-S.; Son, K. J.; Hong, S. J.; Choi, Y. I.; Castilla Valdez, H.; Sanchez Hernandez, A.; Carrillo Moreno, S.; Morelos Pineda, A.; Aerts, A.; Van der Stok, P.; Weffers, H.; Allfrey, P.; Gray, R. N. C.; Hashimoto, M.; Krofcheck, D.; Bell, A. J.; Bernardino Rodrigues, N.; Butler, P. H.; Churchwell, S.; Knegjens, R.; Whitehead, S.; Williams, J. C.; Aftab, Z.; Ahmad, U.; Ahmed, I.; Ahmed, W.; Asghar, M. I.; Asghar, S.; Dad, G.; Hafeez, M.; Hoorani, H. R.; Hussain, I.; Hussain, N.; Iftikhar, M.; Khan, M. S.; Mehmood, K.; Osman, A.; Shahzad, H.; Zafar, A. R.; Ali, A.; Bashir, A.; Jan, A. M.; Kamal, A.; Khan, F.; Saeed, M.; Tanwir, S.; Zafar, M. A.; Blocki, J.; Cyz, A.; Gladysz-Dziadus, E.; Mikocki, S.; Rybczynski, M.; Turnau, J.; Wlodarczyk, Z.; Zychowski, P.; Bunkowski, K.; Cwiok, M.; Czyrkowski, H.; Dabrowski, R.; Dominik, W.; Doroba, K.; Kalinowski, A.; Kierzkowski, K.; Konecki, M.; Krolikowski, J.; Kudla, I. M.; Pietrusinski, M.; Pozniak, K.; Zabolotny, W.; Zych, P.; Gokieli, R.; Goscilo, L.; Górski, M.; Nawrocki, K.; Traczyk, P.; Wrochna, G.; Zalewski, P.; Pozniak, K. T.; Romaniuk, R.; Zabolotny, W. M.; Alemany-Fernandez, R.; Almeida, C.; Almeida, N.; Araujo Vila Verde, A. S.; Barata Monteiro, T.; Bluj, M.; Da Mota Silva, S.; Tinoco Mendes, A. David; Freitas Ferreira, M.; Gallinaro, M.; Husejko, M.; Jain, A.; Kazana, M.; Musella, P.; Nobrega, R.; Rasteiro Da Silva, J.; Ribeiro, P. Q.; Santos, M.; Silva, P.; Silva, S.; Teixeira, I.; Teixeira, J. P.; Varela, J.; Varner, G.; Vaz Cardoso, N.; Altsybeev, I.; Babich, K.; Belkov, A.; Belotelov, I.; Bunin, P.; Chesnevskaya, S.; Elsha, V.; Ershov, Y.; Filozova, I.; Finger, M.; Finger, M., Jr.; Golunov, A.; Golutvin, I.; Gorbounov, N.; Gramenitski, I.; Kalagin, V.; Kamenev, A.; Karjavin, V.; Khabarov, S.; Khabarov, V.; Kiryushin, Y.; Konoplyanikov, V.; Korenkov, V.; Kozlov, G.; Kurenkov, A.; Lanev, A.; Lysiakov, V.; Malakhov, A.; Melnitchenko, I.; Mitsyn, V. V.; Moisenz, K.; Moisenz, P.; Movchan, S.; Nikonov, E.; Oleynik, D.; Palichik, V.; Perelygin, V.; Petrosyan, A.; Rogalev, E.; Samsonov, V.; Savina, M.; Semenov, R.; Sergeev, S.; Shmatov, S.; Shulha, S.; Smirnov, V.; Smolin, D.; Tcheremoukhine, A.; Teryaev, O.; Tikhonenko, E.; Urkinbaev, A.; Vasil'ev, S.; Vishnevskiy, A.; Volodko, A.; Zamiatin, N.; Zarubin, A.; Zarubin, P.; Zubarev, E.; Bondar, N.; Gavrikov, Y.; Golovtsov, V.; Ivanov, Y.; Kim, V.; Kozlov, V.; Lebedev, V.; Makarenkov, G.; Moroz, F.; Neustroev, P.; Obrant, G.; Orishchin, E.; Petrunin, A.; Shcheglov, Y.; Shchetkovskiy, A.; Sknar, V.; Skorobogatov, V.; Smirnov, I.; Sulimov, V.; Tarakanov, V.; Uvarov, L.; Vavilov, S.; Velichko, G.; Volkov, S.; Vorobyev, A.; Chmelev, D.; Druzhkin, D.; Ivanov, A.; Kudinov, V.; Logatchev, O.; Onishchenko, S.; Orlov, A.; Sakharov, V.; Smetannikov, V.; Tikhomirov, A.; Zavodthikov, S.; Andreev, Yu; Anisimov, A.; Duk, V.; Gninenko, S.; Golubev, N.; Gorbunov, D.; Kirsanov, M.; Krasnikov, N.; Matveev, V.; Pashenkov, A.; Pastsyak, A.; Postoev, V. E.; Sadovski, A.; Skassyrskaia, A.; Solovey, Alexander; Solovey, Anatoly; Soloviev, D.; Toropin, A.; Troitsky, S.; Alekhin, A.; Baldov, A.; Epshteyn, V.; Gavrilov, V.; Ilina, N.; Kaftanov, V.; Karpishin, V.; Kiselevich, I.; Kolosov, V.; Kossov, M.; Krokhotin, A.; Kuleshov, S.; Oulianov, A.; Pozdnyakov, A.; Safronov, G.; Semenov, S.; Stepanov, N.; Stolin, V.; Vlasov, E.; Zaytsev, V.; Boos, E.; Dubinin, M.; Dudko, L.; Ershov, A.; Eyyubova, G.; Gribushin, A.; Ilyin, V.; Klyukhin, V.; Kodolova, O.; Kruglov, N. A.; Kryukov, A.; Lokhtin, I.; Malinina, L.; Mikhaylin, V.; Petrushanko, S.; Sarycheva, L.; Savrin, V.; Shamardin, L.; Sherstnev, A.; Snigirev, A.; Teplov, K.; Vardanyan, I.; Fomenko, A. M.; Konovalova, N.; Kozlov, V.; Lebedev, A. I.; Lvova, N.; Rusakov, S. V.; Terkulov, A.; Abramov, V.; Akimenko, S.; Artamonov, A.; Ashimova, A.; Azhgirey, I.; Bitioukov, S.; Chikilev, O.; Datsko, K.; Filine, A.; Godizov, A.; Goncharov, P.; Grishin, V.; Inyakin, A.; Kachanov, V.; Kalinin, A.; Khmelnikov, A.; Konstantinov, D.; Korablev, A.; Krychkine, V.; Krinitsyn, A.; Levine, A.; Lobov, I.; Lukanin, V.; Mel'nik, Y.; Molchanov, V.; Petrov, V.; Petukhov, V.; Pikalov, V.; Ryazanov, A.; Ryutin, R.; Shelikhov, V.; Skvortsov, V.; Slabospitsky, S.; Sobol, A.; Sytine, A.; Talov, V.; Tourtchanovitch, L.; Troshin, S.; Tyurin, N.; Uzunian, A.; Volkov, A.; Zelepoukine, S.; Lukyanov, V.; Mamaeva, G.; Prilutskaya, Z.; Rumyantsev, I.; Sokha, S.; Tataurschikov, S.; Vasilyev, I.; Adzic, P.; Anicin, I.; Djordjevic, M.; Jovanovic, D.; Maletic, D.; Puzovic, J.; Smiljkovic, N.; Aguayo Navarrete, E.; Aguilar-Benitez, M.; Ahijado Munoz, J.; Alarcon Vega, J. M.; Alberdi, J.; Alcaraz Maestre, J.; Aldaya Martin, M.; Arce, P.; Barcala, J. M.; Berdugo, J.; Blanco Ramos, C. L.; Burgos Lazaro, C.; Caballero Bejar, J.; Calvo, E.; Cerrada, M.; Chamizo Llatas, M.; Chercoles Catalán, J. J.; Colino, N.; Daniel, M.; DeLa Cruz, B.; Delgado Peris, A.; Fernandez Bedoya, C.; Ferrando, A.; Fouz, M. C.; Francia Ferrero, D.; Garcia Romero, J.; Garcia-Abia, P.; Gonzalez Lopez, O.; Hernandez, J. M.; Josa, M. I.; Marin, J.; Merino, G.; Molinero, A.; Navarrete, J. J.; Oller, J. C.; Puerta Pelayo, J.; Puras Sanchez, J. C.; Ramirez, J.; Romero, L.; Villanueva Munoz, C.; Willmott, C.; Yuste, C.; Albajar, C.; de Trocóniz, J. F.; Jimenez, I.; Macias, R.; Teixeira, R. F.; Cuevas, J.; Fernández Menéndez, J.; Gonzalez Caballero, I.; Lopez-Garcia, J.; Naves Sordo, H.; Vizan Garcia, J. M.; Cabrillo, I. J.; Calderon, A.; Cano Fernandez, D.; Diaz Merino, I.; Duarte Campderros, J.; Fernandez, M.; Fernandez Menendez, J.; Figueroa, C.; Garcia Moral, L. A.; Gomez, G.; Gomez Casademunt, F.; Gonzalez Sanchez, J.; Gonzalez Suarez, R.; Jorda, C.; Lobelle Pardo, P.; Lopez Garcia, A.; Lopez Virto, A.; Marco, J.; Marco, R.; Martinez Rivero, C.; Martinez Ruiz del Arbol, P.; Matorras, F.; Orviz Fernandez, P.; Patino Revuelta, A.; Rodrigo, T.; Rodriguez Gonzalez, D.; Ruiz Jimeno, A.; Scodellaro, L.; Sobron Sanudo, M.; Vila, I.; Vilar Cortabitarte, R.; Barbero, M.; Goldin, D.; Henrich, B.; Tauscher, L.; Vlachos, S.; Wadhwa, M.; Abbaneo, D.; Abbas, S. M.; Ahmed, I.; Akhtar, S.; Akhtar, M. I.; Albert, E.; Alidra, M.; Ashby, S.; Aspell, P.; Auffray, E.; Baillon, P.; Ball, A.; Bally, S. L.; Bangert, N.; Barillère, R.; Barney, D.; Beauceron, S.; Beaudette, F.; Benelli, G.; Benetta, R.; Benichou, J. L.; Bialas, W.; Bjorkebo, A.; Blechschmidt, D.; Bloch, C.; Bloch, P.; Bonacini, S.; Bos, J.; Bosteels, M.; Boyer, V.; Branson, A.; Breuker, H.; Bruneliere, R.; Buchmuller, O.; Campi, D.; Camporesi, T.; Caner, A.; Cano, E.; Carrone, E.; Cattai, A.; Chatelain, J. P.; Chauvey, M.; Christiansen, T.; Ciganek, M.; Cittolin, S.; Cogan, J.; Conde Garcia, A.; Cornet, H.; Corrin, E.; Corvo, M.; Cucciarelli, S.; Curé, B.; D'Enterria, D.; DeRoeck, A.; de Visser, T.; Delaere, C.; Delattre, M.; Deldicque, C.; Delikaris, D.; Deyrail, D.; Di Vincenzo, S.; Domeniconi, A.; Dos Santos, S.; Duthion, G.; Edera, L. M.; Elliott-Peisert, A.; Eppard, M.; Fanzago, F.; Favre, M.; Foeth, H.; Folch, R.; Frank, N.; Fratianni, S.; Freire, M. A.; Frey, A.; Fucci, A.; Funk, W.; Gaddi, A.; Gagliardi, F.; Gastal, M.; Gateau, M.; Gayde, J. C.; Gerwig, H.; Ghezzi, A.; Gigi, D.; Gill, K.; Giolo-Nicollerat, A. S.; Girod, J. P.; Glege, F.; Glessing, W.; Gomez-Reino Garrido, R.; Goudard, R.; Grabit, R.; Grillet, J. P.; Gutierrez Llamas, P.; Gutierrez Mlot, E.; Gutleber, J.; Hall-wilton, R.; Hammarstrom, R.; Hansen, M.; Harvey, J.; Hervé, A.; Hill, J.; Hoffmann, H. F.; Holzner, A.; Honma, A.; Hufnagel, D.; Huhtinen, M.; Ilie, S. D.; Innocente, V.; Jank, W.; Janot, P.; Jarron, P.; Jeanrenaud, M.; Jouvel, P.; Kerkach, R.; Kloukinas, K.; Kottelat, L. J.; Labbé, J. C.; Lacroix, D.; Lagrue, X.; Lasseur, C.; Laure, E.; Laurens, J. F.; Lazeyras, P.; LeGoff, J. M.; Lebeau, M.; Lecoq, P.; Lemeilleur, F.; Lenzi, M.; Leonardo, N.; Leonidopoulos, C.; Letheren, M.; Liendl, M.; Limia-Conde, F.; Linssen, L.; Ljuslin, C.; Lofstedt, B.; Loos, R.; Lopez Perez, J. A.; Lourenco, C.; Lyonnet, A.; Machard, A.; Mackenzie, R.; Magini, N.; Maire, G.; Malgeri, L.; Malina, R.; Mannelli, M.; Marchioro, A.; Martin, J.; Meijers, F.; Meridiani, P.; Meschi, E.; Meyer, T.; Meynet Cordonnier, A.; Michaud, J. F.; Mirabito, L.; Moser, R.; Mossiere, F.; Muffat-Joly, J.; Mulders, M.; Mulon, J.; Murer, E.; Mättig, P.; Oh, A.; Onnela, A.; Oriunno, M.; Orsini, L.; Osborne, J. A.; Paillard, C.; Pal, I.; Papotti, G.; Passardi, G.; Patino-Revuelta, A.; Patras, V.; Perea Solano, B.; Perez, E.; Perinic, G.; Pernot, J. F.; Petagna, P.; Petiot, P.; Petit, P.; Petrilli, A.; Pfeiffer, A.; Piccut, C.; Pimiä, M.; Pintus, R.; Pioppi, M.; Placci, A.; Pollet, L.; Postema, H.; Price, M. J.; Principe, R.; Racz, A.; Radermacher, E.; Ranieri, R.; Raymond, G.; Rebecchi, P.; Rehn, J.; Reynaud, S.; Rezvani Naraghi, H.; Ricci, D.; Ridel, M.; Risoldi, M.; Rodrigues Simoes Moreira, P.; Rohlev, A.; Roiron, G.; Rolandi, G.; Rumerio, P.; Runolfsson, O.; Ryjov, V.; Sakulin, H.; Samyn, D.; Santos Amaral, L. C.; Sauce, H.; Sbrissa, E.; Scharff-Hansen, P.; Schieferdecker, P.; Schlatter, W. D.; Schmitt, B.; Schmuecker, H. G.; Schröder, M.; Schwick, C.; Schäfer, C.; Segoni, I.; Sempere Roldán, P.; Sgobba, S.; Sharma, A.; Siegrist, P.; Sigaud, C.; Sinanis, N.; Sobrier, T.; Sphicas, P.; Spiropulu, M.; Stefanini, G.; Strandlie, A.; Szoncsó, F.; Taylor, B. G.; Teller, O.; Thea, A.; Tournefier, E.; Treille, D.; Tropea, P.; Troska, J.; Tsesmelis, E.; Tsirou, A.; Valls, J.; Van Vulpen, I.; Vander Donckt, M.; Vasey, F.; Vazquez Acosta, M.; Veillet, L.; Vichoudis, P.; Waurick, G.; Wellisch, J. P.; Wertelaers, P.; Wilhelmsson, M.; Willers, I. M.; Winkler, M.; Zanetti, M.; Bertl, W.; Deiters, K.; Dick, P.; Erdmann, W.; Feichtinger, D.; Gabathuler, K.; Hochman, Z.; Horisberger, R.; Ingram, Q.; Kaestli, H. C.; Kotlinski, D.; König, S.; Poerschke, P.; Renker, D.; Rohe, T.; Sakhelashvili, T.; Starodumov, A.; Aleksandrov, V.; Behner, F.; Beniozef, I.; Betev, B.; Blau, B.; Brett, A. M.; Caminada, L.; Chen, Z.; Chivarov, N.; Da Silva Di Calafiori, D.; Dambach, S.; Davatz, G.; Delachenal, V.; Della Marina, R.; Dimov, H.; Dissertori, G.; Dittmar, M.; Djambazov, L.; Dröge, M.; Eggel, C.; Ehlers, J.; Eichler, R.; Elmiger, M.; Faber, G.; Freudenreich, K.; Fuchs, J. F.; Georgiev, G. M.; Grab, C.; Haller, C.; Herrmann, J.; Hilgers, M.; Hintz, W.; Hofer, Hans; Hofer, Heinz; Horisberger, U.; Horvath, I.; Hristov, A.; Humbertclaude, C.; Iliev, B.; Kastli, W.; Kruse, A.; Kuipers, J.; Langenegger, U.; Lecomte, P.; Lejeune, E.; Leshev, G.; Lesmond, C.; List, B.; Luckey, P. D.; Lustermann, W.; Maillefaud, J. D.; Marchica, C.; Maurisset, A.; Meier, B.; Milenovic, P.; Milesi, M.; Moortgat, F.; Nanov, I.; Nardulli, A.; Nessi-Tedaldi, F.; Panev, B.; Pape, L.; Pauss, F.; Petrov, E.; Petrov, G.; Peynekov, M. M.; Pitzl, D.; Punz, T.; Riboni, P.; Riedlberger, J.; Rizzi, A.; Ronga, F. J.; Roykov, P. A.; Röser, U.; Schinzel, D.; Schöning, A.; Sourkov, A.; Stanishev, K.; Stoenchev, S.; Stöckli, F.; Suter, H.; Trüb, P.; Udriot, S.; Uzunova, D. G.; Veltchev, I.; Viertel, G.; von Gunten, H. P.; Waldmeier-Wicki, S.; Weber, R.; Weber, M.; Weng, J.; Wensveen, M.; Wittgenstein, F.; Zagoursky, K.; Alagoz, E.; Amsler, C.; Chiochia, V.; Hoermann, C.; Regenfus, C.; Robmann, P.; Rommerskirchen, T.; Schmidt, A.; Steiner, S.; Tsirigkas, D.; Wilke, L.; Blyth, S.; Chang, Y. H.; Chen, E. A.; Go, A.; Hung, C. C.; Kuo, C. M.; Li, S. W.; Lin, W.; Chang, P.; Chao, Y.; Chen, K. F.; Gao, Z.; Hou, G. W. S.; Hsiung, Y. B.; Lei, Y. J.; Lin, S. W.; Lu, R. S.; Shiu, J. G.; Tzeng, Y. M.; Ueno, K.; Velikzhanin, Y.; Wang, C. C.; Wang, M.-Z.; Aydin, S.; Azman, A.; Bakirci, M. N.; Basegmez, S.; Cerci, S.; Dumanoglu, I.; Erturk, S.; Eskut, E.; Kayis Topaksu, A.; Kisoglu, H.; Kurt, P.; Ozdemir, K.; Ozdes Koca, N.; Ozkurt, H.; Ozturk, S.; Polatöz, A.; Sogut, K.; Topakli, H.; Vergili, M.; Önengüt, G.; Gamsizkan, H.; Sekmen, S.; Serin-Zeyrek, M.; Sever, R.; Zeyrek, M.; Deliomeroglu, M.; Gülmez, E.; Isiksal, E.; Kaya, M.; Kaya, O.; Ozkorucuklu, S.; Sonmez, N.; Grinev, B.; Lyubynskiy, V.; Senchyshyn, V.; Levchuk, L.; Lukyanenko, S.; Soroka, D.; Sorokin, P.; Zub, S.; Anjum, A.; Baker, N.; Hauer, T.; McClatchey, R.; Odeh, M.; Rogulin, D.; Solomonides, A.; Brooke, J. J.; Croft, R.; Cussans, D.; Evans, D.; Frazier, R.; Grant, N.; Hansen, M.; Head, R. D.; Heath, G. P.; Heath, H. F.; Hill, C.; Huckvale, B.; Jackson, J.; Lynch, C.; Mackay, C. K.; Metson, S.; Nash, S. J.; Newbold, D. M.; Presland, A. D.; Probert, M. G.; Reid, E. C.; Smith, V. J.; Tapper, R. J.; Walton, R.; Bateman, E.; Bell, K. W.; Brown, R. M.; Camanzi, B.; Church, I. T.; Cockerill, D. J. A.; Cole, J. E.; Connolly, J. F.; Coughlan, J. A.; Flower, P. S.; Ford, P.; Francis, V. B.; French, M. J.; Galagedera, S. B.; Gannon, W.; Gay, A. P. R.; Geddes, N. I.; Greenhalgh, R. J. S.; Halsall, R. N. J.; Haynes, W. J.; Hill, J. A.; Jacob, F. R.; Jeffreys, P. W.; Jones, L. L.; Kennedy, B. W.; Lintern, A. L.; Lodge, A. B.; Maddox, A. J.; Morrissey, Q. R.; Murray, P.; Patrick, G. N.; Pattison, C. A. X.; Pearson, M. R.; Quinton, S. P. H.; Rogers, G. J.; Salisbury, J. G.; Shah, A. A.; Shepherd-Themistocleous, C. H.; Smith, B. J.; Sproston, M.; Stephenson, R.; Taghavi, S.; Tomalin, I. R.; Torbet, M. J.; Williams, J. H.; Womersley, W. J.; Worm, S. D.; Xing, F.; Apollonio, M.; Arteche, F.; Bainbridge, R.; Barber, G.; Barrillon, P.; Batten, J.; Beuselinck, R.; Brambilla Hall, P. M.; Britton, D.; Cameron, W.; Clark, D. E.; Clark, I. W.; Colling, D.; Cripps, N.; Davies, G.; Della Negra, M.; Dewhirst, G.; Dris, S.; Foudas, C.; Fulcher, J.; Futyan, D.; Graham, D. J.; Greder, S.; Greenwood, S.; Hall, G.; Hassard, J. F.; Hays, J.; Iles, G.; Kasey, V.; Khaleeq, M.; Leaver, J.; Lewis, P.; MacEvoy, B. C.; Maroney, O.; McLeod, E. M.; Miller, D. G.; Nash, J.; Nikitenko, A.; Noah Messomo, E.; Noy, M.; Papageorgiou, A.; Pesaresi, M.; Petridis, K.; Price, D. R.; Qu, X.; Raymond, D. M.; Rose, A.; Rutherford, S.; Ryan, M. J.; Sciacca, F.; Seez, C.; Sharp, P.; Sidiropoulos, G.; Stettler, M.; Stoye, M.; Striebig, J.; Takahashi, M.; Tallini, H.; Tapper, A.; Timlin, C.; Toudup, L.; Virdee, T.; Wakefield, S.; Walsham, P.; Wardrope, D.; Wingham, M.; Zhang, Y.; Zorba, O.; Da Via, C.; Goitom, I.; Hobson, P. R.; Imrie, D. C.; Reid, I.; Selby, C.; Sharif, O.; Teodorescu, L.; Watts, S. J.; Yaselli, I.; Hazen, E.; Heering, A.; Heister, A.; Lawlor, C.; Lazic, D.; Machado, E.; Rohlf, J.; Sulak, L.; Varela Rodriguez, F.; Wu, S. X.; Avetisyan, A.; Bose, T.; Christofek, L.; Cutts, D.; Esen, S.; Hooper, R.; Landsberg, G.; Narain, M.; Nguyen, D.; Speer, T.; Tsang, K. V.; Breedon, R.; Case, M.; Chertok, M.; Conway, J.; Cox, P. T.; Dolen, J.; Erbacher, R.; Fisyak, Y.; Friis, E.; Grim, G.; Holbrook, B.; Ko, W.; Kopecky, A.; Lander, R.; Lin, F. C.; Lister, A.; Maruyama, S.; Pellett, D.; Rowe, J.; Searle, M.; Smith, J.; Soha, A.; Squires, M.; Tripathi, M.; Vasquez Sierra, R.; Veelken, C.; Andreev, V.; Arisaka, K.; Bonushkin, Y.; Chandramouly, S.; Cline, D.; Cousins, R.; Erhan, S.; Hauser, J.; Ignatenko, M.; Jarvis, C.; Lisowski, B.; Matthey, C.; Mohr, B.; Mumford, J.; Otwinowski, S.; Pischalnikov, Y.; Rakness, G.; Schlein, P.; Shi, Y.; Tannenbaum, B.; Tucker, J.; Valuev, V.; Wallny, R.; Wang, H. G.; Yang, X.; Zheng, Y.; Andreeva, J.; Babb, J.; Campana, S.; Chrisman, D.; Clare, R.; Ellison, J.; Fortin, D.; Gary, J. W.; Gorn, W.; Hanson, G.; Jeng, G. Y.; Kao, S. C.; Layter, J. G.; Liu, F.; Liu, H.; Luthra, A.; Pasztor, G.; Rick, H.; Satpathy, A.; Shen, B. C.; Stringer, R.; Sytnik, V.; Tran, P.; Villa, S.; Wilken, R.; Wimpenny, S.; Zer-Zion, D.; Branson, J. G.; Coarasa Perez, J. A.; Dusinberre, E.; Kelley, R.; Lebourgeois, M.; Letts, J.; Lipeles, E.; Mangano, B.; Martin, T.; Mojaver, M.; Muelmenstaedt, J.; Norman, M.; Paar, H. P.; Petrucci, A.; Pi, H.; Pieri, M.; Rana, A.; Sani, M.; Sharma, V.; Simon, S.; White, A.; Würthwein, F.; Yagil, A.; Affolder, A.; Allen, A.; Campagnari, C.; D'Alfonso, M.; Dierlamm, A.; Garberson, J.; Hale, D.; Incandela, J.; Kalavase, P.; Koay, S. A.; Kovalskyi, D.; Krutelyov, V.; Kyre, S.; Lamb, J.; Lowette, S.; Nikolic, M.; Pavlunin, V.; Rebassoo, F.; Ribnik, J.; Richman, J.; Rossin, R.; Shah, Y. S.; Stuart, D.; Swain, S.; Vlimant, J. R.; White, D.; Witherell, M.; Bornheim, A.; Bunn, J.; Chen, J.; Denis, G.; Galvez, P.; Gataullin, M.; Legrand, I.; Litvine, V.; Ma, Y.; Mao, R.; Nae, D.; Narsky, I.; Newman, H. B.; Orimoto, T.; Rogan, C.; Shevchenko, S.; Steenberg, C.; Su, X.; Thomas, M.; Timciuc, V.; van Lingen, F.; Veverka, J.; Voicu, B. R.; Weinstein, A.; Wilkinson, R.; Xia, Y.; Yang, Y.; Zhang, L. Y.; Zhu, K.; Zhu, R. Y.; Ferguson, T.; Jang, D. W.; Jun, S. Y.; Paulini, M.; Russ, J.; Terentyev, N.; Vogel, H.; Vorobiev, I.; Bunce, M.; Cumalat, J. P.; Dinardo, M. E.; Drell, B. R.; Ford, W. T.; Givens, K.; Heyburn, B.; Johnson, D.; Nauenberg, U.; Stenson, K.; Wagner, S. R.; Agostino, L.; Alexander, J.; Blekman, F.; Cassel, D.; Das, S.; Duboscq, J. E.; Gibbons, L. K.; Heltsley, B.; Jones, C. D.; Kuznetsov, V.; Patterson, J. R.; Riley, D.; Ryd, A.; Stroiney, S.; Sun, W.; Thom, J.; Vaughan, J.; Wittich, P.; Beetz, C. P.; Cirino, G.; Podrasky, V.; Sanzeni, C.; Winn, D.; Abdullin, S.; Afaq, M. A.; Albrow, M.; Amundson, J.; Apollinari, G.; Atac, M.; Badgett, W.; Bakken, J. A.; Baldin, B.; Banicz, K.; Bauerdick, L. A. T.; Baumbaugh, A.; Berryhill, J.; Bhat, P. C.; Binkley, M.; Bloch, I.; Borcherding, F.; Boubekeur, A.; Bowden, M.; Burkett, K.; Butler, J. N.; Cheung, H. W. K.; Chevenier, G.; Chlebana, F.; Churin, I.; Cihangir, S.; Dagenhart, W.; Demarteau, M.; Dykstra, D.; Eartly, D. P.; Elias, J. E.; Elvira, V. D.; Evans, D.; Fisk, I.; Freeman, J.; Gaines, I.; Gartung, P.; Geurts, F. J. M.; Giacchetti, L.; Glenzinski, D. A.; Gottschalk, E.; Grassi, T.; Green, D.; Grimm, C.; Guo, Y.; Gutsche, O.; Hahn, A.; Hanlon, J.; Harris, R. M.; Hesselroth, T.; Holm, S.; Holzman, B.; James, E.; Jensen, H.; Johnson, M.; Joshi, U.; Klima, B.; Kossiakov, S.; Kousouris, K.; Kowalkowski, J.; Kramer, T.; Kwan, S.; Lei, C. M.; Leininger, M.; Los, S.; Lueking, L.; Lukhanin, G.; Lusin, S.; Maeshima, K.; Marraffino, J. M.; Mason, D.; McBride, P.; Miao, T.; Moccia, S.; Mokhov, N.; Mrenna, S.; Murray, S. J.; Newman-Holmes, C.; Noeding, C.; O'Dell, V.; Paterno, M.; Petravick, D.; Pordes, R.; Prokofyev, O.; Ratnikova, N.; Ronzhin, A.; Sekhri, V.; Sexton-Kennedy, E.; Sfiligoi, I.; Shaw, T. M.; Skup, E.; Smith, R. P.; Spalding, W. J.; Spiegel, L.; Stavrianakou, M.; Stiehr, G.; Stone, A. L.; Suzuki, I.; Tan, P.; Tanenbaum, W.; Temple, L. E.; Tkaczyk, S.; Uplegger, L.; Vaandering, E. W.; Vidal, R.; Wands, R.; Wenzel, H.; Whitmore, J.; Wicklund, E.; Wu, W. M.; Wu, Y.; Yarba, J.; Yarba, V.; Yumiceva, F.; Yun, J. C.; Zimmerman, T.; Acosta, D.; Avery, P.; Barashko, V.; Bartalini, P.; Bourilkov, D.; Cavanaugh, R.; Dolinsky, S.; Drozdetskiy, A.; Field, R. D.; Fu, Y.; Furic, I. K.; Gorn, L.; Holmes, D.; Kim, B. J.; Klimenko, S.; Konigsberg, J.; Korytov, A.; Kotov, K.; Levchenko, P.; Madorsky, A.; Matchev, K.; Mitselmakher, G.; Pakhotin, Y.; Prescott, C.; Ramond, L.; Ramond, P.; Schmitt, M.; Scurlock, B.; Stasko, J.; Stoeck, H.; Wang, D.; Yelton, J.; Gaultney, V.; Kramer, L.; Lebolo, L. M.; Linn, S.; Markowitz, P.; Martinez, G.; Rodriguez, J. L.; Adams, T.; Askew, A.; Atramentov, O.; Bertoldi, M.; Dharmaratna, W. G. D.; Gershtein, Y.; Gleyzer, S. V.; Hagopian, S.; Hagopian, V.; Jenkins, C. J.; Johnson, K. F.; Prosper, H.; Simek, D.; Thomaston, J.; Baarmand, M.; Baksay, L.; Guragain, S.; Hohlmann, M.; Mermerkaya, H.; Ralich, R.; Vodopiyanov, I.; Adams, M. R.; Anghel, I. M.; Apanasevich, L.; Barannikova, O.; Bazterra, V. E.; Betts, R. R.; Dragoiu, C.; Garcia-Solis, E. J.; Gerber, C. E.; Hofman, D. J.; Hollis, R.; Iordanova, A.; Khalatian, S.; Mironov, C.; Shabalina, E.; Smoron, A.; Varelas, N.; Akgun, U.; Albayrak, E. A.; Ayan, A. S.; Briggs, R.; Cankocak, K.; Clarida, W.; Cooper, A.; Debbins, P.; Duru, F.; Fountain, M.; McCliment, E.; Merlo, J. P.; Mestvirishvili, A.; Miller, M. J.; Moeller, A.; Newsom, C. R.; Norbeck, E.; Olson, J.; Onel, Y.; Perera, L.; Schmidt, I.; Wang, S.; Yetkin, T.; Anderson, E. W.; Chakir, H.; Hauptman, J. M.; Lamsa, J.; Barnett, B. A.; Blumenfeld, B.; Chien, C. Y.; Giurgiu, G.; Gritsan, A.; Kim, D. W.; Lae, C. K.; Maksimovic, P.; Swartz, M.; Tran, N.; Baringer, P.; Bean, A.; Chen, J.; Coppage, D.; Grachov, O.; Murray, M.; Radicci, V.; Wood, J. S.; Zhukova, V.; Bandurin, D.; Bolton, T.; Kaadze, K.; Kahl, W. E.; Maravin, Y.; Onoprienko, D.; Sidwell, R.; Wan, Z.; Dahmes, B.; Gronberg, J.; Hollar, J.; Lange, D.; Wright, D.; Wuest, C. R.; Baden, D.; Bard, R.; Eno, S. C.; Ferencek, D.; Hadley, N. J.; Kellogg, R. G.; Kirn, M.; Kunori, S.; Lockner, E.; Ratnikov, F.; Santanastasio, F.; Skuja, A.; Toole, T.; Wang, L.; Wetstein, M.; Alver, B.; Ballintijn, M.; Bauer, G.; Busza, W.; Gomez Ceballos, G.; Hahn, K. A.; Harris, P.; Klute, M.; Kravchenko, I.; Li, W.; Loizides, C.; Ma, T.; Nahn, S.; Paus, C.; Pavlon, S.; Piedra Gomez, J.; Roland, C.; Roland, G.; Rudolph, M.; Stephans, G.; Sumorok, K.; Vaurynovich, S.; Wenger, E. A.; Wyslouch, B.; Bailleux, D.; Cooper, S.; Cushman, P.; DeBenedetti, A.; Dolgopolov, A.; Dudero, P. R.; Egeland, R.; Franzoni, G.; Gilbert, W. J.; Gong, D.; Grahl, J.; Haupt, J.; Klapoetke, K.; Kronkvist, I.; Kubota, Y.; Mans, J.; Rusack, R.; Sengupta, S.; Sherwood, B.; Singovsky, A.; Vikas, P.; Zhang, J.; Booke, M.; Cremaldi, L. M.; Godang, R.; Kroeger, R.; Reep, M.; Reidy, J.; Sanders, D. A.; Sonnek, P.; Summers, D.; Watkins, S.; Bloom, K.; Bockelman, B.; Claes, D. R.; Dominguez, A.; Eads, M.; Furukawa, M.; Keller, J.; Kelly, T.; Lundstedt, C.; Malik, S.; Snow, G. R.; Swanson, D.; Ecklund, K. M.; Iashvili, I.; Kharchilava, A.; Kumar, A.; Strang, M.; Alverson, G.; Barberis, E.; Boeriu, O.; Eulisse, G.; McCauley, T.; Musienko, Y.; Muzaffar, S.; Osborne, I.; Reucroft, S.; Swain, J.; Taylor, L.; Tuura, L.; Gobbi, B.; Kubantsev, M.; Kubik, A.; Ofierzynski, R. A.; Schmitt, M.; Spencer, E.; Stoynev, S.; Szleper, M.; Velasco, M.; Won, S.; Andert, K.; Baumbaugh, B.; Beiersdorf, B. A.; Castle, L.; Chorny, J.; Goussiou, A.; Hildreth, M.; Jessop, C.; Karmgard, D. J.; Kolberg, T.; Marchant, J.; Marinelli, N.; McKenna, M.; Ruchti, R.; Vigneault, M.; Wayne, M.; Wiand, D.; Bylsma, B.; Durkin, L. S.; Gilmore, J.; Gu, J.; Killewald, P.; Ling, T. Y.; Rush, C. J.; Sehgal, V.; Williams, G.; Adam, N.; Chidzik, S.; Denes, P.; Elmer, P.; Garmash, A.; Gerbaudo, D.; Halyo, V.; Jones, J.; Marlow, D.; Olsen, J.; Piroué, P.; Stickland, D.; Tully, C.; Werner, J. S.; Wildish, T.; Wynhoff, S.; Xie, Z.; Huang, X. T.; Lopez, A.; Mendez, H.; Ramirez Vargas, J. E.; Zatserklyaniy, A.; Apresyan, A.; Arndt, K.; Barnes, V. E.; Bolla, G.; Bortoletto, D.; Bujak, A.; Everett, A.; Fahling, M.; Garfinkel, A. F.; Gutay, L.; Ippolito, N.; Kozhevnikov, Y.; Laasanen, A. T.; Liu, C.; Maroussov, V.; Medved, S.; Merkel, P.; Miller, D. H.; Miyamoto, J.; Neumeister, N.; Pompos, A.; Roy, A.; Sedov, A.; Shipsey, I.; Cuplov, V.; Parashar, N.; Bargassa, P.; Lee, S. J.; Liu, J. H.; Maronde, D.; Matveev, M.; Nussbaum, T.; Padley, B. P.; Roberts, J.; Tumanov, A.; Bodek, A.; Budd, H.; Cammin, J.; Chung, Y. S.; DeBarbaro, P.; Demina, R.; Ginther, G.; Gotra, Y.; Korjenevski, S.; Miner, D. C.; Sakumoto, W.; Slattery, P.; Zielinski, M.; Bhatti, A.; Demortier, L.; Goulianos, K.; Hatakeyama, K.; Mesropian, C.; Bartz, E.; Chuang, S. H.; Doroshenko, J.; Halkiadakis, E.; Jacques, P. F.; Khits, D.; Lath, A.; Macpherson, A.; Plano, R.; Rose, K.; Schnetzer, S.; Somalwar, S.; Stone, R.; Watts, T. L.; Cerizza, G.; Hollingsworth, M.; Lazoflores, J.; Ragghianti, G.; Spanier, S.; York, A.; Aurisano, A.; Golyash, A.; Kamon, T.; Nguyen, C. N.; Pivarski, J.; Safonov, A.; Toback, D.; Weinberger, M.; Akchurin, N.; Berntzon, L.; Carrell, K. W.; Gumus, K.; Jeong, C.; Kim, H.; Lee, S. W.; McGonagill, B. G.; Roh, Y.; Sill, A.; Spezziga, M.; Thomas, R.; Volobouev, I.; Washington, E.; Wigmans, R.; Yazgan, E.; Bapty, T.; Engh, D.; Florez, C.; Johns, W.; Keskinpala, T.; Luiggi Lopez, E.; Neema, S.; Nordstrom, S.; Pathak, S.; Sheldon, P.; Andelin, D.; Arenton, M. W.; Balazs, M.; Buehler, M.; Conetti, S.; Cox, B.; Hirosky, R.; Humphrey, M.; Imlay, R.; Ledovskoy, A.; Phillips, D., II; Powell, H.; Ronquest, M.; Yohay, R.; Anderson, M.; Baek, Y. W.; Bellinger, J. N.; Bradley, D.; Cannarsa, P.; Carlsmith, D.; Crotty, I.; Dasu, S.; Feyzi, F.; Gorski, T.; Gray, L.; Grogg, K. S.; Grothe, M.; Jaworski, M.; Klabbers, P.; Klukas, J.; Lanaro, A.; Lazaridis, C.; Leonard, J.; Loveless, R.; Magrans de Abril, M.; Mohapatra, A.; Ott, G.; Smith, W. H.; Weinberg, M.; Wenman, D.; Atoian, G. S.; Dhawan, S.; Issakov, V.; Neal, H.; Poblaguev, A.; Zeller, M. E.; Abdullaeva, G.; Avezov, A.; Fazylov, M. I.; Gasanov, E. M.; Khugaev, A.; Koblik, Y. N.; Nishonov, M.; Olimov, K.; Umaraliev, A.; Yuldashev, B. S.

    2008-08-01

    The Compact Muon Solenoid (CMS) detector is described. The detector operates at the Large Hadron Collider (LHC) at CERN. It was conceived to study proton-proton (and lead-lead) collisions at a centre-of-mass energy of 14 TeV (5.5 TeV nucleon-nucleon) and at luminosities up to 1034 cm-2 s-1 (1027 cm-2 s-1). At the core of the CMS detector sits a high-magnetic-field and large-bore superconducting solenoid surrounding an all-silicon pixel and strip tracker, a lead-tungstate scintillating-crystals electromagnetic calorimeter, and a brass-scintillator sampling hadron calorimeter. The iron yoke of the flux-return is instrumented with four stations of muon detectors covering most of the 4π solid angle. Forward sampling calorimeters extend the pseudorapidity coverage to high values (|η| <= 5) assuring very good hermeticity. The overall dimensions of the CMS detector are a length of 21.6 m, a diameter of 14.6 m and a total weight of 12500 t.

  3. Specialized minimal PDFs for optimized LHC calculations.

    PubMed

    Carrazza, Stefano; Forte, Stefano; Kassabov, Zahari; Rojo, Juan

    2016-01-01

    We present a methodology for the construction of parton distribution functions (PDFs) designed to provide an accurate representation of PDF uncertainties for specific processes or classes of processes with a minimal number of PDF error sets: specialized minimal PDF sets, or SM-PDFs. We construct these SM-PDFs in such a way that sets corresponding to different input processes can be combined without losing information, specifically as regards their correlations, and that they are robust upon smooth variations of the kinematic cuts. The proposed strategy never discards information, so that the SM-PDF sets can be enlarged by the addition of new processes, until the prior PDF set is eventually recovered for a large enough set of processes. We illustrate the method by producing SM-PDFs tailored to Higgs, top-quark pair, and electroweak gauge boson physics, and we determine that, when the PDF4LHC15 combined set is used as the prior, around 11, 4, and 11 Hessian eigenvectors, respectively, are enough to fully describe the corresponding processes.

  4. Pigment-dependence of LHC assembly, structure, and function

    SciTech Connect

    Plumley, F.G.; Weston, B.; Stafford, R.A. ); Schmidt, G.W. )

    1993-05-01

    The role of pigments in the assembly and function of light-harvesting complexes in incompletely understood. A Chl b- and neoxanthin-deficient Chlamydomonas mutant (GE2.27) was isolated. Surprisingly, the rate of PSII-dependent O[sub 2] evolution at light-limiting conditions in mutant GE2.27 is reduced to the same extent as in another Chlamydomonas mutant completely devoid of LHC apoproteins. Thus, the partially assembled LHCs of GE2,27 do not functionally interact with PSII. Protease treatments of thylakoids reveal that the LHC proteins of GE2.27 are both hypersensitive and digested at unique sites indicating that the partially assembled LHC proteins of GE2.27 have an altered topological organization. Because thylakoid proteins from both PSI- and PSII-deficient mutants do not exhibit alterations in their susceptibility to exogenous proteases, the topological changes observed in GE2.27 LHC proteins are not a result of their propensity to associate with PSI or their apparent inability to functionally associate with PSII.Partially assembled LHCs, containing only Chl a, lutein, loroxanthin and violaxanthin were purified from GE2.27 thylakoids. the data indicate the altered topology as assessed by protease digestion assays are not simply due to the absence of Chl b and/or neoxanthin as proteolytic shields. We suggest that assembly of Chl b is required for proper folding of LHC proteins in thylakoid membranes and the conformational changes facilitate assembly and, therefore, accumulation of neoxanthin. Finally, neither Chl b nor neoxanthin is required for LHC association with PSI but one or more of these pigments is necessary to promote LHC association with PSII reaction centers. This is the first demonstration of pigment-dependent modulation of thylakoid protein conformation and function.

  5. Stepping outside the neighborhood of T at LHC

    NASA Astrophysics Data System (ADS)

    Wiedemann, Urs Achim

    2009-11-01

    “ As you are well aware, many in the RHIC community are interested in the LHC heavy-ion program, but have several questions: What can we learn at the LHC that is qualitatively new? Are collisions at LHC similar to RHIC ones, just with a somewhat hotter/denser initial state? If not, why not? These questions are asked in good faith, and this talk is an opportunity to answer them directly to much of the RHIC community.” With these words, the organizers of Quark Matter 2009 in Knoxville invited me to discuss the physics opportunities for heavy ion collisions at the LHC without recalling the standard arguments, which are mainly based on the extended kinematic reach of the machine. In response, I emphasize here that lattice QCD indicates characteristic qualitative differences between thermal physics in the neighborhood of the critical temperature (T400-500MeV), for which the relevant energy densities will be solely attainable at the LHC.

  6. Shaping Collaboration 2006: action items for the LHC

    NASA Astrophysics Data System (ADS)

    Goldfarb, S.; Herr, J.; Neal, H. A.

    2008-07-01

    Shaping Collaboration 2006 [1] was a workshop held in Geneva, on December 11-13, 2006, to examine the status and future of collaborative tool technology and its usage for large global scientific collaborations, such as those of the CERN LHC [2]. The workshop brought together some of the leading experts in the field of collaborative tools (WACE 2006) [3] with physicists and developers of the LHC collaborations and HENP (High-Energy and Nuclear Physics). We highlight important presentations and key discussions held during the workshop, then focus on a large and aggressive set of goals and specific action items targeted at institutes from all levels of the LHC organization. This list of action items, assembled during a panel discussion at the close of the LHC sessions, includes recommendations for the LHC Users, their Universities, Project Managers, Spokespersons, National Funding Agencies and Host Laboratories. We present this list, along with suggestions for priorities in addressing the immediate and long-term needs of HENP.

  7. Handbook of LHC Higgs Cross Sections: 3. Higgs Properties

    SciTech Connect

    Heinemeyer, S; et al.

    2013-01-01

    This Report summarizes the results of the activities in 2012 and the first half of 2013 of the LHC Higgs Cross Section Working Group. The main goal of the working group was to present the state of the art of Higgs Physics at the LHC, integrating all new results that have appeared in the last few years. This report follows the first working group report Handbook of LHC Higgs Cross Sections: 1. Inclusive Observables (CERN-2011-002) and the second working group report Handbook of LHC Higgs Cross Sections: 2. Differential Distributions (CERN-2012-002). After the discovery of a Higgs boson at the LHC in mid-2012 this report focuses on refined prediction of Standard Model (SM) Higgs phenomenology around the experimentally observed value of 125-126 GeV, refined predictions for heavy SM-like Higgs bosons as well as predictions in the Minimal Supersymmetric Standard Model and first steps to go beyond these models. The other main focus is on the extraction of the characteristics and properties of the newly discovered particle such as couplings to SM particles, spin and CP-quantum numbers etc.

  8. Pixel Hybridization Technologies for the HL-LHC

    NASA Astrophysics Data System (ADS)

    Alimonti, G.; Biasotti, M.; Ceriale, V.; Darbo, G.; Gariano, G.; Gaudiello, A.; Gemme, C.; Rossi, L.; Rovani, A.; Ruscino, E.

    2016-12-01

    During the 2024-2025 shut-down, the Large Hadron Collider (LHC) will be upgraded to reach an instantaneous luminosity up to 7×1034 cm-2s-1. This upgrade of the collider is called High-Luminosity LHC (HL-LHC). ATLAS and CMS detectors will be upgraded to meet the new challenges of HL-LHC: an average of 200 pile-up events in every bunch crossing and an integrated luminosity of 3000 fb-1 over ten years. In particular, the current trackers will be completely replaced. In HL-LHC the trackers should operate under high fluences (up to 1.4 × 1016 neq cm-2), with a correlated high radiation damage. The pixel detectors, the innermost part of the trackers, needed a completely new design in the readout electronics, sensors and interconnections. A new 65 nm front-end (FE) electronics is being developed by the RD53 collaboration compatible with smaller pixel sizes than the actual ones to cope with the high track densities. Consequently the bump density will increase up to 4 ·104 bumps/cm2. Preliminary results of two hybridization technologies study are presented in this paper. In particular, the on-going bump-bonding qualification program at Leonardo-Finmeccanica is discussed, together with alternative hybridization techniques, as the capacitive coupling for HV-CMOS detectors.

  9. Supersymmetry, Naturalness, and Signatures at the LHC

    SciTech Connect

    Kitano, Ryuichiro; Nomura, Yasunori

    2006-02-10

    Weak scale supersymmetry is often said to be fine-tuned, especially if the matter content is minimal. This is not true if there is a large A term for the top squarks. We present a systematic study on fine-tuning in minimal supersymmetric theories and identify low energy spectra that do not lead to severe fine-tuning. Characteristic features of these spectra are: a large A term for the top squarks, small top squark masses, moderately large tan {beta}, and a small {mu} parameter. There are classes of theories leading to these features, which are discussed. In one class, which allows a complete elimination of fine-tuning, the Higgsinos are the lightest among all the superpartners of the standard model particles, leading to three nearly degenerate neutralino/chargino states. This gives interesting signals at the LHC--the dilepton invariant mass distribution has a very small endpoint and shows a particular shape determined by the Higgsino nature of the two lightest neutralinos. We demonstrate that these signals are indeed useful in realistic analyses by performing Monte Carlo simulations, including detector simulations and background estimations. We also present a method that allows the determination of all the relevant superparticle masses without using input from particular models, despite the limited kinematical information due to short cascades. This allows us to test various possible models, which is demonstrated in the case of a model with mixed moduli-anomaly mediation. We also give a simple derivation of special renormalization group properties associated with moduli mediated supersymmetry breaking, which are relevant in a model without fine-tuning.

  10. Supersymmetry, Naturalness, and Signatures at the LHC

    SciTech Connect

    Kitano, Ryuichiro; Nomura, Yasunori

    2006-02-21

    Weak scale supersymmetry is often said to be fine-tuned, especially if the matter content is minimal. This is not true if there is a large {Alpha} term for the top squarks. We present a systematic study on fine-tuning in minimal supersymmetric theories and identify low energy spectra that do not lead to severe .ne-tuning. Characteristic features of these spectra are: a large {Alpha} term for the top squarks, small top squark masses, moderately large tan {beta}, and a small {mu} parameter. There are classes of theories leading to these features, which are discussed. In one class, which allows a complete elimination of fine-tuning, the Higgsinos are the lightest among all the superpartners of the standard model particles, leading to three nearly degenerate neutralino/chargino states. This gives interesting signals at the LHC--the dilepton invariant mass distribution has a very small endpoint and shows a particular shape determined by the Higgsino nature of the two lightest neutralinos. We demonstrate that these signals are indeed useful in realistic analyses by performing Monte Carlo simulations, including detector simulations and background estimations. We also present a method that allows the determination of all the relevant superparticle masses without using input from particular models, despite the limited kinematical information due to short cascades. This allows us to test various possible models, which is demonstrated in the case of a model with mixed moduli-anomaly mediation. We also give a simple derivation of special renormalization group properties associated with moduli mediated supersymmetry breaking, which are relevant in a model without fine-tuning.

  11. Natural generalized mirage mediation

    NASA Astrophysics Data System (ADS)

    Baer, Howard; Barger, Vernon; Serce, Hasan; Tata, Xerxes

    2016-12-01

    In the supersymmetric scenario known as mirage mediation (MM), the soft supersymmetry (SUSY) breaking terms receive comparable anomaly-mediation and moduli-mediation contributions leading to the phenomenon of mirage unification. The simplest MM SUSY breaking models which are consistent with the measured Higgs mass and sparticle mass constraints are strongly disfavored by fine-tuning considerations. However, while MM makes robust predictions for gaugino masses, the scalar sector is quite sensitive to specific mechanisms for moduli stabilization and potential uplifting. We suggest here a broader setup of generalized mirage mediation (GMM), where heretofore discrete parameters are allowed as continuous to better parametrize these other schemes. We find that natural SUSY spectra consistent with both the measured value of mh as well as LHC lower bounds on superpartner masses are then possible. We explicitly show that models generated from natural GMM may be beyond the reach of even high-luminosity LHC searches. In such a case, the proposed International Linear e+e- Collider will be required for natural SUSY discovery via higgsino pair production reactions. We also outline prospects for detection of higgsino-like WIMPs from natural GMM.

  12. Optics of a 1.5 TeV injector for the LHC

    SciTech Connect

    Johnstone, John A.; /Fermilab

    2006-07-01

    A concept is being developed to install a second, low energy ring (LER) above the LHC to accelerate protons from 450 GeV to 1.5 TeV prior to injection into the LHC. The arc and dispersion suppresser optics of the LHC would be replicated in the LER using combined function ''transmission line'' magnets originally proposed for the VLHC. To avoid costly civil construction, in the straight sections housing detectors at least, the LER and LHC must share beampipes and some magnets through the detector portion of the straights. Creating the appropriate optics for these LER-LHC transition regions is very challenging: In addition to matching to the nominal LHC lattice functions at these locations the changes in altitude of 1.35 m separating the LER and LHC must be performed achromatically to avoid emittance blowup arising from vertical dispersion when the beams are transferred to the LHC.

  13. Kaluza-Klein Dark Matter: Direct Detection vis-a-vis LHC

    SciTech Connect

    Arrenberg, Sebastian; Baudis, Laura; Kong, Kyoungchul; Matchev, Konstantin T.; Yoo, Jonghee; /Fermilab

    2008-11-01

    We explore the phenomenology of Kaluza-Klein (KK) dark matter in very general models with universal extra dimensions (UEDs), emphasizing the complementarity between high-energy colliders and dark matter direct detection experiments. In models with relatively small mass splittings between the dark matter candidate and the rest of the (colored) spectrum, the collider sensitivity is diminished, but direct detection rates are enhanced. UEDs provide a natural framework for such mass degeneracies. We consider both 5-dimensional and 6-dimensional non-minimal UED models, and discuss the detection prospects for various KK dark matter candidates: the KK photon {gamma}{sub 1} (5D) the KK Z-boson Z{sub 1} (5D) and the spinless KK photon {gamma}{sub H} (6D). We combine collider limits such as electroweak precision data and expected LHC reach, with cosmological constraints from WMAP and the sensitivity of current or planned direct detection experiments. Allowing for general mass splittings, we show that neither colliders, nor direct detection experiments by themselves can explore all of the relevant KK dark matter parameter space. Nevertheless, they probe different parameter space regions and the combination of the two types of constraints can be quite powerful. For example, in the case of {gamma}{sub 1} in 5D UEDs the relevant parameter space will be almost completely covered by the combined LHC and direct detection sensitivities expected in the near future.

  14. Kaluza-Klein dark matter: Direct detection vis-a-vis CERN LHC

    SciTech Connect

    Arrenberg, Sebastian; Baudis, Laura; Kong, Kyoungchul; Matchev, Konstantin T.; Yoo, Jonghee

    2008-09-01

    We explore the phenomenology of Kaluza-Klein (KK) dark matter in very general models with universal extra dimensions (UEDs), emphasizing the complementarity between high-energy colliders and dark matter direct detection experiments. In models with relatively small mass splittings between the dark matter candidate and the rest of the (colored) spectrum, the collider sensitivity is diminished, but direct detection rates are enhanced. UEDs provide a natural framework for such mass degeneracies. We consider both five-dimensional and six-dimensional nonminimal UED models, and discuss the detection prospects for various KK dark matter candidates: the KK photon {gamma}{sub 1}, the KK Z boson Z{sub 1}, the KK Higgs boson H{sub 1}, and the spinless KK photon {gamma}{sub H}. We combine collider limits, such as electroweak precision data and expected LHC reach, with cosmological constraints from WMAP, and the sensitivity of current or planned direct detection experiments. Allowing for general mass splittings, we show that neither colliders nor direct detection experiments by themselves can explore all of the relevant KK dark matter parameter space. Nevertheless, they probe different parameter space regions, and the combination of the two types of constraints can be quite powerful. For example, in the case of {gamma}{sub 1} in 5D UEDs the relevant parameter space will be almost completely covered by the combined CERN LHC and direct detection sensitivities expected in the near future.

  15. Stashing the stops in multijet events at the LHC

    NASA Astrophysics Data System (ADS)

    Diglio, Sara; Feligioni, Lorenzo; Moultaka, Gilbert

    2017-09-01

    While the presence of a light stop is increasingly disfavored by the experimental limits set on R-parity conserving scenarios, the naturalness of supersymmetry could still be safely concealed in the more challenging final states predicted by the existence of non-null R-parity violating couplings. Although R-parity violating signatures are extensively looked for at the Large Hadron Collider, these searches mostly assume 100% branching ratios for the direct decays of supersymmetric particles into Standard Model ones. In this paper we scrutinize the implications of relaxing this assumption by focusing on one motivated scenario where the lightest stop is heavier than a chargino and a neutralino. Considering a class of R-parity baryon number violating couplings, we show on general grounds that while the direct decay of the stop into Standard Model particles is dominant for large values of these couplings, smaller values give rise, instead, to the dominance of a plethora of longer decay chains and richer final states that have been so far barely analyzed at the LHC, thus weakening the impact of the present experimental stop mass limits. We characterize the case for R-parity baryon number violating couplings in the 10-7-10-1 range, in two different benchmark points scenarios within the model-independent setting of the low-energy phenomenological Minimal Supersymmetric Standard Model. We identify the different relevant experimental signatures from stop pair production and decays, estimate the corresponding proton-proton cross sections at √{s }=14 TeV and discuss signal versus background issues.

  16. Summary of the Mini BNL/LARP/CARE-HHH Workshop on Crab Cavities for the LHC (LHC-CC08)

    SciTech Connect

    Ben-Zvi,I.; Calaga, R.; Zimmermann, F.

    2008-05-01

    The first mini-workshop on crab compensation for the LHC luminosity upgrade (LHC-CC08) was held February 24-25, 2008 at the Brookhaven National Laboratory. A total of 35 participants from 3 continents and 15 institutions from around the world participated to discuss the exciting prospect of a crab scheme for the LHC. If realized it will be the first demonstration in hadron colliders. The workshop is organized by joint collaboration of BNL, US-LARP and CARE-HHH. The enormous interest in the subject of crab cavities for the international linear collider and future light sources has resulted in a large international collaboration to exchange aspects of synergy and expertise. A central repository for this exchange of information documenting the latest design effort for LHC crab cavities is consolidated in a wiki page: https://twiki.cern.ch/twiki/bin/view/Main/LHCCrabCavities. The main goal of this workshop was to define a road-map for a prototype crab cavity to be installed in the LHC and to discuss the associated R&D and beam dynamics challenges. The diverse subject of implementing the crab scheme resulted in a scientific program with a wide range of subtopics which were divided into 8 sessions. Each session was given a list of fundamental questions to be addressed and used as a guideline to steer the discussions.

  17. New Tools for Forecasting Old Physics at the LHC

    ScienceCinema

    None

    2016-07-12

    For the LHC to uncover many types of new physics, the "old physics" produced by the Standard Model must be understood very well. For decades, the central theoretical tool for this job was the Feynman diagram expansion. However, Feynman diagrams are just too slow, even on fast computers, to allow adequate precision for complicated LHC events with many jets in the final state. Such events are already visible in the initial LHC data. Over the past few years, alternative methods to Feynman diagrams have come to fruition. These new "on-shell" methods are based on the old principles of unitarity and factorization. They can be much more efficient because they exploit the underlying simplicity of scattering amplitudes, and recycle lower-loop information. I will describe how and why these methods work, and present some of the recent state-of-the-art results that have been obtained with them.

  18. Tevatron-for-LHC Report of the QCD Working Group

    SciTech Connect

    Albrow, Michael G.; Begel, M.; Bourilkov, D.; Campanelli, M.; Chlebana, F.; De Roeck, A.; Dittmann, J.R.; Ellis, S.D.; Field, B.; Field, R.; Gallinaro, M.; /Fermilab /Rochester U. /Florida U. /Geneva U. /CERN /Baylor U. /Washington U., Seattle /Florida State U. /Rockefeller U. /Prague, Tech. U. /Michigan State U.

    2006-10-01

    The experiments at Run 2 of the Tevatron have each accumulated over 1 fb{sup -1} of high-transverse momentum data. Such a dataset allows for the first precision (i.e. comparisons between theory and experiment at the few percent level) tests of QCD at a hadron collider. While the Large Hadron Collider has been designed as a discovery machine, basic QCD analyses will still need to be performed to understand the working environment. The Tevatron-for-LHC workshop was conceived as a communication link to pass on the expertise of the Tevatron and to test new analysis ideas coming from the LHC community. The TeV4LHC QCD Working Group focused on important aspects of QCD at hadron colliders: jet definitions, extraction and use of Parton Distribution Functions, the underlying event, Monte Carlo tunes, and diffractive physics. This report summarizes some of the results achieved during this workshop.

  19. SMALL ANGLE CRAB COMPENSATION FOR LHC IR UPGRADE

    SciTech Connect

    CALAGA,R.; DORDA, U.; OHMI, D.; OIDE, K.; TOMAS, R.; ZIMMERMANN, F.

    2007-06-25

    A small angle (< 1 mrad) crab scheme is an attractive option for the LHC luminosity upgrade to recover the geometric luminosity loss from the finite crossing angle [I]. The luminosity loss increases steeply to unacceptable levels as the IP beta function is reduced below its nominal value (see Fig. 1 in Ref. [2]). The crab compensation in the LHC can be accomplished using only two sets of deflecting RF cavities, placed in collision-free straight sections of the LHC to nullify the effective crossing angles at IPI & IP5. We also explore a 400 MHz superconducting cavity design and discuss the pertinent RF challenges. We present IR optics configurations with low-angle crab crossing, study the beam-beam performance and proton-beam emittance growth in the presence of crab compensation, lattice errors, and crab RF noise sources.

  20. Scalar-mediated double beta decay and LHC

    NASA Astrophysics Data System (ADS)

    Gonzalez, L.; Helo, J. C.; Hirsch, M.; Kovalenko, S. G.

    2016-12-01

    The decay rate of neutrinoless double beta (0 νββ) decay could be dominated by Lepton Number Violating (LNV) short-range diagrams involving only heavy scalar intermediate particles, known as "topology-II" diagrams. Examples are diagrams with diquarks, leptoquarks or charged scalars. Here, we compare the LNV discovery potentials of the LHC and 0 νββ-decay experiments, resorting to three example models, which cover the range of the optimistic-pessimistic cases for 0 νββ decay. We use the LHC constraints from dijet as well as leptoquark searches and find that already with 20/fb the LHC will test interesting parts of the parameter space of these models, not excluded by the current limits on 0 νββ-decay.

  1. SUPERCONDUCTING DIPOLE MAGNETS FOR THE LHC INSERTION REGIONS

    SciTech Connect

    WILLEN,E.; ANERELLA,M.; COZZOLINO,J.; GANETIS,G.; GHOSH,A.; GUPTA,R.; HARRISON,M.; JAIN,A.; MARONE,A.; MURATORE,J.; PLATE,S.; SCHMALZLE,J.; WANDERER,P.; WU,K.C.

    2000-06-26

    Dipole bending magnets are required to change the horizontal separation of the two beams in the LHC. In Intersection Regions (IR) 1, 2, 5, and 8, the beams are brought into collision for the experiments located there. In IR4, the separation of the beams is increased to accommodate the machine's particle acceleration hardware. As part of the US contribution to the LHC Project, BNL is building the required superconducting magnets. Designs have been developed featuring a single aperture cold mass in a single cryostat, two single aperture cold masses in a single cryostat, and a dual aperture cold mass in a single cryostat. All configurations feature the 80 mm diameter, 10 m long superconducting coil design used in the main bending magnets of the Relativistic Heavy Ion Collider recently completed at Brookhaven. The magnets for the LHC, to be built at Brookhaven, are described and results from the program to build two dual aperture prototypes are presented.

  2. Searching for anomalous top quark production at the early LHC.

    PubMed

    Gao, Jun; Li, Chong Sheng; Yang, Li Lin; Zhang, Hao

    2011-08-26

    We present a detailed study of the anomalous top quark production with subsequent decay at the LHC induced by model-independent flavor-changing neutral-current couplings, incorporating the complete next-to-leading order QCD effects. Our results show that, taking into account the current limits from the Tevatron, the LHC with √s=7  TeV may discover the anomalous coupling at 5σ level for a very low integrated luminosity of 61  pb⁻¹. The discovery potentials for the anomalous couplings at the LHC are examined in detail. We also discuss the possibility of using the charge ratio to distinguish the tug and tcg couplings.

  3. Quark-lepton symmetric model at the LHC

    NASA Astrophysics Data System (ADS)

    Clarke, Jackson D.; Foot, Robert; Volkas, Raymond R.

    2012-04-01

    We investigate the quark-lepton symmetric model of Foot and Lew in the context of the Large Hadron Collider (LHC). In this “bottom-up” extension to the standard model, quark-lepton symmetry is achieved by introducing a gauged “leptonic color” symmetry which is spontaneously broken above the electroweak scale. If this breaking occurs at the TeV scale, then we expect new physics to be discovered at the LHC. We examine three areas of interest: the Z' heavy neutral gauge boson, charge ±1/2 exotic leptons, and a color triplet scalar diquark. We find that the LHC has already explored and/or will explore new parameter space for these particles over the course of its lifetime.

  4. First Attempts at using Active Halo Control at the LHC

    SciTech Connect

    Wagner, Joschka; Bruce, Roderik; Garcia Morales, Hector; Höfle, Wolfgang; Kotzian, Gerd; Kwee-Hinzmann, Regina; Langner, Andy; Mereghetti, Alessio; Quaranta, Elena; Redaelli, Stefano; Rossi, Adriana; Salvachua, Belen; Stancari, Giulio; Tomás, Rogelio; Valentino, Gianluca; Valuch, Daniel

    2016-06-01

    The beam halo population is a non-negligible factor for the performance of the LHC collimation system and the machine protection. In particular this could become crucial for aiming at stored beam energies of 700 MJ in the High Luminosity (HL-LHC) project, in order to avoid beam dumps caused by orbit jitter and to ensure safety during a crab cavity failure. Therefore several techniques to safely deplete the halo, i.e. active halo control, are under development. In a first attempt a novel way for safe halo depletion was tested with particle narrow-band excitation employing the LHC Transverse Damper (ADT). At an energy of 450 GeV a bunch selective beam tail scraping without affecting the core distribution was attempted. This paper presents the first measurement results, as well as a simple simulation to model the underlying dynamics.

  5. Confronting lepton flavor universality violation in B decays with high-pT tau lepton searches at LHC

    NASA Astrophysics Data System (ADS)

    Faroughy, Darius A.; Greljo, Admir; Kamenik, Jernej F.

    2017-01-01

    We confront the indications of lepton flavor universality (LFU) violation observed in semi-tauonic B meson decays with new physics (NP) searches using high pT tau leptons at the LHC. Using effective field theory arguments we correlate possible non-standard contributions to semi-tauonic charged currents with the τ+τ- signature at high energy hadron colliders. Several representative standard model extensions put forward to explain the anomaly are examined in detail: (i) weak triplet of color-neutral vector resonances, (ii) second Higgs doublet and (iii) scalar or (iv) vector leptoquark. We find that, in general, τ+τ- searches pose a serious challenge to NP explanations of the LFU anomaly. Recasting existing 8 TeV and 13 TeV LHC analyses, stringent limits are set on all considered simplified models. Future projections of the τ+τ- constraints as well as caveats in interpreting them within more elaborate models are also discussed.

  6. Detailed analysis of flavor-changing decays of top quarks as a probe of new physics at the LHC

    NASA Astrophysics Data System (ADS)

    Bardhan, Debjyoti; Bhattacharyya, Gautam; Ghosh, Diptimoy; Patra, Monalisa; Raychaudhuri, Sreerup

    2016-07-01

    If the LHC should fail to observe direct signals for new physics, it may become necessary to look for new physics effects in rare events such as flavor-changing decays of the top quark, which, in the standard model, are predicted to be too small to be observed. We set up the theoretical framework in which experimentally accessible results can be expected in models of new physics, and go on to discuss two models of supersymmetry—one with conserved R -parity, and one without R -parity—to illustrate how the flavor-changing signals are predicted in these models. In the latter case, there is a distinct possibility of detecting the rare decay t →c +Z0 at the LHC. We also present a detailed set of very general formulas which can be used to make similar calculations in diverse models of new physics.

  7. Asymptotic safety and Kaluza-Klein gravitons at the LHC

    SciTech Connect

    Gerwick, Erik; Litim, Daniel; Plehn, Tilman

    2011-04-15

    We study Drell-Yan production at the LHC in low-scale quantum gravity models with extra dimensions. Asymptotic safety implies that the ultraviolet behavior of gravity is dictated by a fixed point. We show how the energy dependence of Newton's coupling regularizes the gravitational amplitude using a renormalization group improvement. We study LHC predictions and find that Kaluza-Klein graviton signals are well above standard model backgrounds. This leaves a significant sensitivity to the energy scale {Lambda}{sub T} where the gravitational couplings crossover from classical to fixed point scaling.

  8. Heavy particles at the LHC and in cosmic rays

    NASA Astrophysics Data System (ADS)

    Petrukhin, A. A.; Bogdanov, A. G.

    2017-09-01

    Direct production of heavy particles and their indirect signatures, detected at the LHC as anomalous events, are considered. Analogous anomalous events at comparable c.m.s. energies were detected in cosmic-ray experiments several decades ago. All these exotic phenomena and processes can be interpreted from a common viewpoint by assuming the production of quark-gluon blobs with large orbital momenta which hinder the emission of light rather than heavy quarks including the top quarks. The prospects for testing this model in the LHC experiments are discussed.

  9. Multivariate Search of the Standard Model Higgs Boson at LHC

    SciTech Connect

    Mjahed, Mostafa

    2007-01-12

    resent an attempt to identify the SM Higgs boson at LHC in the channel (pp-bar {yields} HX {yields} W+ W-X {yields} l+ vl- v X). We use a multivariate processing of data as a tool for a better discrimination between signal and background (via Principal Components Analysis, Genetic Algorithms and Neural Network). Events were produced at LHC energies (MH = 140 - 200 GeV), using the Lund Monte Carlo generator PYTHIA 6.1. Higgs boson events (pp-bar {yields} HX {yields} W+W-X {yields} l+ vl- v X) and the most relevant background are considered.

  10. JINR Tier-1 centre for the CMS experiment at LHC

    NASA Astrophysics Data System (ADS)

    Astakhov, N. S.; Baginyan, A. S.; Belov, S. D.; Dolbilov, A. G.; Golunov, A. O.; Gorbunov, I. N.; Gromova, N. I.; Kadochnikov, I. S.; Kashunin, I. A.; Korenkov, V. V.; Mitsyn, V. V.; Pelevanyuk, I. S.; Shmatov, S. V.; Strizh, T. A.; Tikhonenko, E. A.; Trofimov, V. V.; Voitishin, N. N.; Zhiltsov, V. E.

    2016-09-01

    An overview of the JINR Tier-1 centre for the CMS experiment at the LHC is given. Special emphasis is placed on the main tasks and services of the CMS Tier-1 at JINR. In February 2015 the JINR CMS Tier-1 resources were increased to the level that was outlined in JINR's rollout plan: CPU 2400 cores (28800 HEP-Spec06), 2.4 PB disks, and 5.0 PB tapes. The first results of the Tier-1 operations received during the LHC Run-2 start are presented.

  11. Small-x physics in coherent pp interactions at LHC

    NASA Astrophysics Data System (ADS)

    Gonçalves, V. P.; Machado, M. V. T.; Meneses, A. R.

    2009-03-01

    In this contribution we analyze the electromagnetic interactions present in hadron-hadron collisions at the LHC energy and summarize our estimate for the total cross sections for the diffractive photoproduction of vector mesons in the hh→hXh process (X = J/Ψ,Υ), which are characterized by two rapidity gaps in the final state. In particular, we discuss the possibility to constrain the gluon distribution using this process. Our results demonstrate that the study of these processes is feasible considering the proton tagging detectors (Roman Pots) already planned for the initial start-up of the LHC.

  12. Cold matter effects and quarkonium production at RHIC and LHC

    SciTech Connect

    Dos Santos, G. S.; Mariotto, C. B.; Goncalves, V. P.

    2013-03-25

    In this work we investigate two cold matter effects in J/{Psi} and {Upsilon} production in nuclear collisions at RHIC and LHC, namely the shadowing effect and nuclear absorption. We characterize these effects by estimating the rapidity dependence of some nuclear ratios in pA and AA collisions at RHIC and LHC, R{sub pA} = d{sigma}{sub pA}(J/{Psi},{Upsilon})/Ad{sigma}{sub pp}(J/{Psi},{Upsilon}) and R{sub AA} = d{sigma}{sub AA}(J/{Psi},{Upsilon})/A{sup 2}d{sigma}{sub pp}(J/{Psi},{Upsilon}).

  13. Performance of the LHCb RICH detector at the LHC.

    PubMed

    Adinolfi, M; Aglieri Rinella, G; Albrecht, E; Bellunato, T; Benson, S; Blake, T; Blanks, C; Brisbane, S; Brook, N H; Calvi, M; Cameron, B; Cardinale, R; Carson, L; Contu, A; Coombes, M; D'Ambrosio, C; Easo, S; Egede, U; Eisenhardt, S; Fanchini, E; Fitzpatrick, C; Fontanelli, F; Forty, R; Frei, C; Gandini, P; Gao, R; Garra Tico, J; Giachero, A; Gibson, V; Gotti, C; Gregson, S; Gys, T; Haines, S C; Hampson, T; Harnew, N; Hill, D; Hunt, P; John, M; Jones, C R; Johnson, D; Kanaya, N; Katvars, S; Kerzel, U; Kim, Y M; Koblitz, S; Kucharczyk, M; Lambert, D; Main, A; Maino, M; Malde, S; Mangiafave, N; Matteuzzi, C; Mini', G; Mollen, A; Morant, J; Mountain, R; Morris, J V; Muheim, F; Muresan, R; Nardulli, J; Owen, P; Papanestis, A; Patel, M; Patrick, G N; Perego, D L; Pessina, G; Petrolini, A; Piedigrossi, D; Plackett, R; Playfer, S; Powell, A; Rademacker, J H; Ricciardi, S; Rogers, G J; Sail, P; Sannino, M; Savidge, T; Sepp, I; Sigurdsson, S; Soler, F J P; Solomin, A; Soomro, F; Sparkes, A; Spradlin, P; Storaci, B; Thomas, C; Topp-Joergensen, S; Torr, N; Ullaland, O; Vervink, K; Voong, D; Websdale, D; Wilkinson, G; Wotton, S A; Wyllie, K; Xing, F; Young, R

    The LHCb experiment has been taking data at the Large Hadron Collider (LHC) at CERN since the end of 2009. One of its key detector components is the Ring-Imaging Cherenkov (RICH) system. This provides charged particle identification over a wide momentum range, from 2-100 GeV/c. The operation and control, software, and online monitoring of the RICH system are described. The particle identification performance is presented, as measured using data from the LHC. Excellent separation of hadronic particle types (π, K, p) is achieved.

  14. Lepton Number Violation in Higgs Decay at LHC.

    PubMed

    Maiezza, Alessio; Nemevšek, Miha; Nesti, Fabrizio

    2015-08-21

    We show that within the left-right symmetric model, lepton number violating decays of the Higgs boson can be discovered at the LHC. The process is due to the mixing of the Higgs boson with the triplet that breaks parity. As a result, the Higgs boson can act as a gateway to the origin of the heavy Majorana neutrino mass. To assess the LHC reach, a detailed collider study of the same-sign dileptons plus jets channel is provided. This process is complementary to the existing nuclear and collider searches for lepton number violation and can probe the scale of parity restoration even beyond other direct searches.

  15. Pixel DAQ and trigger for HL-LHC

    NASA Astrophysics Data System (ADS)

    Morettini, P.

    2017-03-01

    The read-out is one of the challenges in the design of a pixel detector for the High Luminosity upgrade of the Large Hadron Collider (HL-LHC), that is expected to operate from 2026 at a leveled luminosity of 5 × 1034 cm‑2 s‑1. This is especially true if tracking information is needed in a low latency trigger system. The difficulties of a fast read-out will be reviewed, and possible strategies explained. The solutions that are being evaluated by the ATLAS and CMS collaborations for the upgrade of their trackers will be outlined and ideas on possible development beyond HL-LHC will be presented.

  16. Hints for a nonstandard Higgs boson from the LHC

    SciTech Connect

    Raidal, Martti; Strumia, Alessandro

    2011-10-01

    We reconsider Higgs boson invisible decays into Dark Matter in the light of recent Higgs searches at the LHC. Present hints in the Compact Muon Solenoid and ATLAS data favor a nonstandard Higgs boson with approximately 50% invisible branching ratio, and mass around 143 GeV. This situation can be realized within the simplest thermal scalar singlet Dark Matter model, predicting a Dark Matter mass around 50 GeV and direct detection cross section just below present bound. The present runs of the Xenon100 and LHC experiments can test this possibility.

  17. Identification of the Origin of Monojet Signatures at the LHC

    SciTech Connect

    Rizzo, Thomas G.; /SLAC

    2008-05-13

    Several new physics scenarios can lead to monojet signatures at the LHC. If such events are observed above the Standard Model background it will be important to identify their origin. In this paper we compare and contrast these signatures as produced in two very different pictures: vector or scalar unparticle production in the scale-invariant/conformal regime and graviton emission in the Arkani-Hamed, Dimopoulos and Dvali extra-dimensional model. We demonstrate that these two scenarios can be distinguished at the LHC for a reasonable range of model parameters through the shape of their respective monojet and/or missing E{sub T} distributions.

  18. The pMSSM Interpretation of LHC Results Using Rernormalization Group Invariants

    SciTech Connect

    Carena, Marcela; Lykken, Joseph; Sekmen, Sezen; Shah, Nausheen R.; Wagner, Carlos E.M.

    2012-10-01

    The LHC has started to constrain supersymmetry-breaking parameters by setting bounds on possible colored particles at the weak scale. Moreover, constraints from Higgs physics, flavor physics, the anomalous magnetic moment of the muon, as well as from searches at LEP and the Tevatron have set additional bounds on these parameters. Renormalization Group Invariants (RGIs) provide a very useful way of representing the allowed parameter space by making direct connection with the values of these parameters at the messenger scale. Using a general approach, based on the pMSSM parametrization of the soft supersymmetry-breaking parameters, we analyze the current experimental constraints to determine the probability distributions for the RGIs. As examples of their application, we use these distributions to analyze the question of Gaugino Mass Unification and to probabilistically determine the parameters of General and Minimal Gauge Mediation with arbitrary Higgs mass parameters at the Messenger Scale.

  19. Multicore job scheduling in the Worldwide LHC Computing Grid

    NASA Astrophysics Data System (ADS)

    Forti, A.; Pérez-Calero Yzquierdo, A.; Hartmann, T.; Alef, M.; Lahiff, A.; Templon, J.; Dal Pra, S.; Gila, M.; Skipsey, S.; Acosta-Silva, C.; Filipcic, A.; Walker, R.; Walker, C. J.; Traynor, D.; Gadrat, S.

    2015-12-01

    After the successful first run of the LHC, data taking is scheduled to restart in Summer 2015 with experimental conditions leading to increased data volumes and event complexity. In order to process the data generated in such scenario and exploit the multicore architectures of current CPUs, the LHC experiments have developed parallelized software for data reconstruction and simulation. However, a good fraction of their computing effort is still expected to be executed as single-core tasks. Therefore, jobs with diverse resources requirements will be distributed across the Worldwide LHC Computing Grid (WLCG), making workload scheduling a complex problem in itself. In response to this challenge, the WLCG Multicore Deployment Task Force has been created in order to coordinate the joint effort from experiments and WLCG sites. The main objective is to ensure the convergence of approaches from the different LHC Virtual Organizations (VOs) to make the best use of the shared resources in order to satisfy their new computing needs, minimizing any inefficiency originated from the scheduling mechanisms, and without imposing unnecessary complexities in the way sites manage their resources. This paper describes the activities and progress of the Task Force related to the aforementioned topics, including experiences from key sites on how to best use different batch system technologies, the evolution of workload submission tools by the experiments and the knowledge gained from scale tests of the different proposed job submission strategies.

  20. Constraining Higgsino kink tracks from existing LHC searches

    NASA Astrophysics Data System (ADS)

    Jung, Sunghoon; Lee, Hye-Sung

    2017-05-01

    Considering the supersymmetric model with the long-lived charged Higgsino, we discuss how Higgsino kink signals can show up in the latest LHC Disappearing Track (DT) and stable chargino searches. We derive constraints on the Higgsino kink signal, and characterize it in comparison to the Wino DT and the slepton kink track. We also discuss how to infer Higgsino model kinematics.

  1. Corona effect in AA collisions at the LHC

    NASA Astrophysics Data System (ADS)

    Pantuev, V. S.

    2017-05-01

    Following our earlier finding based on RHIC data on the dominant jet production from nucleus corona region, we reconsider this effect in nucleus-nucleus collisions at the LHC energies. Our hypothesis was based on experimental data, which raised the idea of a finite formation time for the produced medium. At the RHIC energy and in low-density corona region, this time reaches about 2 fm/ c. Following this hypothesis, the nuclear modification factor R AA at high p t should be independent on particle momentum, and the azimuthal anisotropy of high p t particles, v 2, should be finite. A separate prediction held that, at the LHC energy, the formation time in the corona region should be about 1 fm/ c. New LHC data show that R AA is not flat and is rising with p t . We add to our original hypothesis an assumption that a fast parton traversing the produced medium loses the fixed portion of its energy. A shift of about 7 GeV from the original power law p -6 production cross section in pp explains well all the observed R AA dependencies. The shift of about 7 GeV is also valid at the RHIC energy. We also show that the observed at the LHC dependence of v 2 at high p t and our previous predictions agree.

  2. Forward physics using proton tagging at the LHC

    SciTech Connect

    Royon, Christophe

    2015-04-10

    We describe different physics topics that can be performed at the LHC using tagged intact protons leading to a better understanding of the Pomeron structure in terms of quarks and gluons and to unprecedented sensitivities to quartic anomalous couplings between γ and W/Z bosons.

  3. Simulation Study of Hollow Electron Beam Collimation for LHC

    SciTech Connect

    Valishev, A.

    2014-05-02

    In this note we describe the results of numerical simulations of hollow electron beam collimation for the nominal LHC machine. The halo cleaning rates for various operating scenarios are predicted. The impact of electron lens imperfections on the collider luminosity performance is estimated.

  4. ALICE and The state of matter at LHC

    ScienceCinema

    None

    2016-07-12

    Assembly and installation of ALICE, the LHC heavy ion experiment dedicated to the study of matter at extreme temperature and pressure, is nearing completion and the commissioning of the detector is well under way. A good time to look back, to the making of ALICE, and to look forward, to the first physics with proton and heavy ion beams.

  5. Double Pomeron Exchange: from the ISR to the LHC

    NASA Astrophysics Data System (ADS)

    Albrow, Michael

    2011-07-01

    I discuss Double Pomeron Exchange processes from their first observation at the CERN Intersecting Storage Rings, focusing on glueball searches, through the observations of exclusive χc0, γγ and di-jets at the Tevatron, to prospects at the LHC for exclusive Higgs boson production.

  6. Hadronic and electromagnetic fragmentation of ultrarelativistic heavy ions at LHC

    NASA Astrophysics Data System (ADS)

    Braun, H. H.; Fassò, A.; Ferrari, A.; Jowett, J. M.; Sala, P. R.; Smirnov, G. I.

    2014-02-01

    Reliable predictions of yields of nuclear fragments produced in electromagnetic dissociation and hadronic fragmentation of ion beams are of great practical importance in analyzing beam losses and interactions with the beam environment at the Large Hadron Collider (LHC) at CERN as well as for estimating radiation effects of galactic cosmic rays on the spacecraft crew and electronic equipment. The model for predicting the fragmentation of relativistic heavy ions is briefly described, and then applied to problems of relevance for LHC. The results are based on the fluka code, which includes electromagnetic dissociation physics and dpmjet-iii as hadronic event generator. We consider the interaction of fully stripped lead ions with nuclei in the energy range from about one hundred MeV to ultrarelativistic energies. The yields of fragments close in the mass and charge to initial ions are calculated. The approach under discussion provides a good overall description of Pb fragmentation data at 30 and 158A GeV as well as recent LHC data for √sNN =2.76 TeV Pb-Pb interactions. Good agreement with the calculations in the framework of different models is found. This justifies application of the developed simulation technique both at the LHC injection energy of 177A GeV and at its collision energies of 1.38, 1.58, and 2.75A TeV, and gives confidence in the results obtained.

  7. Analysis of optics designs for the LHC IR upgrade

    SciTech Connect

    Sen, Tanaji; Johnstone, John; /Fermilab

    2007-06-01

    We consider the different options proposed for the LHC IR upgrade. The two main categories: quadrupoles first (as in the baseline design) and dipoles-first have complementary strengths. We analyze the potential of the proposed designs by calculating important performance parameters. We also propose a local scheme for correcting the quadratic chromaticity.

  8. Constraining Higgsino kink tracks from existing LHC searches

    DOE PAGES

    Jung, Sunghoon; Lee, Hye -Sung

    2017-04-26

    Considering the supersymmetric model with the long-lived charged Higgsino, we discuss how Higgsino kink signals can show up in the latest LHC Disappearing Track (DT) and stable chargino searches. We derive constraints on the Higgsino kink signal, and characterize it in comparison to the Wino DT and the slepton kink track. Here, we also discuss how to infer Higgsino model kinematics.

  9. A full-acceptance detector at the LHC (FELIX)

    SciTech Connect

    Ageev, A.; Akhobadze, K.; Alvero, L.; Amelino-Camelia, G.; Avati, V.; Baier, R.; Bartels, J.; Baur, G.; Beneke, M.; Berera, A.; Bjorken, J.D.; Bondila, M.; Britvich, I.; Capella, A.; Close, F.; Collins, J.; Costa, C.; Cudell, J.-R.; Derevschikov, A.; Dick, L.; Djordjadze, V.; Dokshitzer, Yu; Donnachie, A.; Eggert, K.; Engel, R.; Frankfurt, L.; Geiger, K.; Giovannini, A.; Goloskokov, S.; Goulianos, K.; Gridasov, V.; Gustafson, H.R.; Halzen, F.; Hencken, K.; Inyakin, A.; Islam, M.M.; Jones, L.; Kaidalov, A.B.; Karapetian, G.; Karapetian, V.; Karpushov, I.D.; Kashtanov, E.; Kharlov, Y.; Khoze, V.; Klein, S.; Klimenko, E.Yu; Kozlov, O.; Kowalski, K.; Kubarovsky, A.V.; Landshoff, P.V.; Leflat, A.K.; Lippmaa, E.; Manankov, V.M.; Marchesini, G.; Medvedkov, A.; Mokhnatuk, V.A.; Mueller, A.H.; Murzin, V.S.; Myznikov, K.; Nikitin, V.; Nomokonov, P.; Novikov, S.I.; Orava, R.; Ostonen, R.; Ouvarov, V.; Papageorgiou, E.; Polyakov, V.; Raidal, M.; Rainwater, D.; Ranft, J.; Riege, H.; Roufanov, I.; Rubin, N.; Sadovsky, S.; Salam, G.P.; Sauli, F.; Schiff, D.; Selyugin, O.; Shabalina, E.K.; Shabratova, G.; Shuvalou, S.; Smirnov, V.; Strikman, M.; Subbi, J.; Sytnik, V.; Taylor, C.; Tikhonova, L.A.; Toukhtarov, A.; Treleani, D.; Ugoccioni, R.; Vasilchenko, V.; Vasiliev, A.; Vasiliev, L.; White, A.; Whitmore, J.; Wlodarczyk, Z.; Yakovlev, V.; Yushchenko, O.; Zeppenfeld, D.; Zhalov, M.; Zinchenko, S.; Zotov, N.P.

    2002-01-02

    The FELIX collaboration had proposed the construction of a full-acceptance detector for the LHC. The primary mission of FELIX was the study of QCD: to provide comprehensive and definitive observations of a very broad range of strong-interaction processes. This document contains an extensive discussion of this physics menu. In a further paper the FELIX detector will be reviewed.

  10. Some interesting min-bias distributions for early LHC runs

    SciTech Connect

    Skands, P.Z.; /CERN /Fermilab

    2007-12-01

    A few observable distributions in min-bias (inelastic, non-diffractive) events which could be well constrained with early LHC data are presented, with some comments on their significance for placing constraints on theoretical models. The effects of fiducial cuts (p{perpendicular} > 0.5 GeV, |{eta}| < 2.5) and extrapolation from the Tevatron are illustrated.

  11. Double Pomeron Exchange: from the ISR to the LHC

    SciTech Connect

    Albrow, Michael; /Fermilab

    2010-09-01

    I discuss Double Pomeron Exchange processes from their first observation at the CERN Intersecting Storage Rings, focusing on glueball searches, through the observations of exclusive {chi}{sub c0}, {gamma}{gamma} and di-jets at the Tevatron, to prospects at the LHC for exclusive Higgs boson production.

  12. CERN and LHC - their place in global science

    ScienceCinema

    None

    2016-07-12

    The Large Hadron Collider (LHC) is the largest scientific instrument in the world. It brings into collision intense beams of protons and ions to explore the structure of matter and investigate the forces of nature at an unprecedented energy scale, thus serving a community of some 7,000 particle physicists from all over the world.

  13. From Rindler horizon to mini black holes at LHC

    NASA Astrophysics Data System (ADS)

    Ghaffary, Tooraj

    2017-02-01

    Recently researchers (A. Sepehri et al., Astrophys. Space Sci. 344, 79 (2013)) have considered the signature of superstring balls near mini black holes at LHC and calculate the information loss for these types of strings. Motivated by their work, we consider the evolution of events in high energy experiments from lower energies for which the Rindler horizon is formed to higher energies in which mini black holes and string balls are emerged. Extending the Gottesman and Preskill method to string theory, we find the information loss for excited strings "string balls" in mini black holes at LHC and calculate the information transformation from the collapsing matter to the state of outgoing Hawking radiation for strings. We come to the conclusion that information transformation for high energy strings is complete. Then the thermal distribution of excited strings near mini black holes at LHC is calculated. In order to obtain the total string cross section near black holes produced in proton-proton collision, we multiply the black hole production cross section by the thermal distribution of strings. It is observed that many high energy excited strings are produced near the event horizon of TeV black holes. These excited strings evaporate to standard model particles like Higgs boson and top quark at Hagedorn temperature. We derive the production cross section for these particles due to string ball decay at LHC and consider their decay to light particles like bottom quarks and gluons.

  14. Double Pomeron Exchange: from the ISR to the LHC

    SciTech Connect

    Albrow, Michael

    2011-07-15

    I discuss Double Pomeron Exchange processes from their first observation at the CERN Intersecting Storage Rings, focusing on glueball searches, through the observations of exclusive {chi}{sub c0},{gamma}{gamma} and di-jets at the Tevatron, to prospects at the LHC for exclusive Higgs boson production.

  15. Diffractive Measurements at the LHC: Elastic and Inelastic Soft Diffraction

    SciTech Connect

    Orava, Risto

    2011-07-15

    A short review of four topics was presented: (1) Photon bremsstrahlung in elastic proton-proton scattering, (2) Low mass Single Diffraction (SD), (3) Low mass Central Exclusive Diffraction (CED), and (4) Event classification of the pp interactions at the LHC. This article summarizes topic (1).

  16. Baseline review of the U.S. LHC Accelerator project

    SciTech Connect

    1998-02-01

    The Department of Energy (DOE) Review of the U.S. Large Hadron Collider (LHC) Accelerator project was conducted February 23--26, 1998, at the request of Dr. John R. O`Fallon, Director, Division of High Energy Physics, Office of Energy Research, U.S. DOE. This is the first review of the U.S. LHC Accelerator project. Overall, the Committee found that the U.S. LHC Accelerator project effort is off to a good start and that the proposed scope is very conservative for the funding available. The Committee recommends that the project be initially baselined at a total cost of $110 million, with a scheduled completion data of 2005. The U.S. LHC Accelerator project will supply high technology superconducting magnets for the interaction regions (IRs) and the radio frequency (rf) straight section of the LHC intersecting storage rings. In addition, the project provides the cryogenic support interface boxes to service the magnets and radiation absorbers to protect the IR dipoles and the inner triplet quadrupoles. US scientists will provide support in analyzing some of the detailed aspects of accelerator physics in the two rings. The three laboratories participating in this project are Brookhaven National Laboratory, Fermi National Accelerator Laboratory (Fermilab), and Lawrence Berkeley National Laboratory. The Committee was very impressed by the technical capabilities of the US LHC Accelerator project team. Cost estimates for each subsystem of the US LHC Accelerator project were presented to the Review Committee, with a total cost including contingency of $110 million (then year dollars). The cost estimates were deemed to be conservative. A re-examination of the funding profile, costs, and schedules on a centralized project basis should lead to an increased list of deliverables. The Committee concluded that the proposed scope of US deliverables to CERN can be readily accomplished with the $110 million total cost baseline for the project. The current deliverables should serve as

  17. Supersymmetry-breaking parameters from renormalization group invariants at the LHC.

    SciTech Connect

    Carena, M.; Draper, P.; Shah, N. R.; Wagner, C. E. M.

    2011-02-18

    We study renormalization group invariant (RGI) quantities in the minimal supersymmetric standard model and show that they are a powerful and simple instrument for testing high-scale models of supersymmetry (SUSY) breaking. For illustration, we analyze the frameworks of minimal and general gauge-mediated (MGM and GGM) SUSY breaking, with additional arbitrary soft Higgs mass parameters at the messenger scale. We show that if a gaugino and two first generation sfermion soft masses are determined at the LHC, the RGIs lead to MGM sum rules that yield accurate predictions for the other gaugino and first generation soft masses. RGIs can also be used to reconstruct the fundamental MGM parameters (including the messenger scale), calculate the hypercharge D-term, and find relationships among the third generation and Higgs soft masses. We then study the extent to which measurements of the full first generation spectrum at the LHC may distinguish different SUSY-breaking scenarios. In the case of the MGM model, although most deviations violate the sum rules by more than estimated experimental errors, we find a one-parameter family of GGM models that satisfy the constraints and produce the same first generation spectrum. The GGM-MGM degeneracy is lifted by differences in the third generation masses and the messenger scales.

  18. Detection and analysis of atmospheric muons using the ALICE detector at the LHC

    NASA Astrophysics Data System (ADS)

    Alessandro, Bruno

    2017-06-01

    ALICE is a general purpose experiment designed to investigate nucleus-nucleus collisions at the CERN Large Hadron Collider (LHC). Located 52 meters underground, with 28 meters of overburden rock, it has also been used to detect the muonic component of the extensive air showers produced by cosmic-ray interactions in the upper atmosphere. A program of cosmic-ray data taking, with specific triggers for atmospheric muons, was started in 2010 in periods when there is no beam circulating in the LHC. Several million events have been recorded to date. The large size and excellent tracking capability of the ALICE Time Projection Chamber are exploited to detect and reconstruct these muons. In this paper the analysis of the multiplicity distribution of the atmospheric muons detected by ALICE between 2010 and 2013 is presented, along with the comparison with Monte Carlo simulations. Special emphasis is given to the study of high multiplicity events containing more than 100 reconstructed muons. The comprehension of the frequency of these events was an unsolved problem since the pioneering studies performed by ALEPH and DELPHI experiments at LEP. In our work the ALICE measurements show that such high multiplicity events demand primary cosmic rays with energy above 1016 eV. Their frequency can be successfully described by assuming a heavy mass composition of primary cosmic rays above this energy and using the most recent interaction models to describe the development of the air shower resulting from the primary interaction.

  19. Supersymmetry-breaking parameters from renormalization group invariants at the LHC

    SciTech Connect

    Carena, Marcela; Draper, Patrick; Shah, Nausheen R.; Wagner, Carlos E. M.

    2011-02-01

    We study renormalization group invariant (RGI) quantities in the minimal supersymmetric standard model and show that they are a powerful and simple instrument for testing high-scale models of supersymmetry (SUSY) breaking. For illustration, we analyze the frameworks of minimal and general gauge-mediated (MGM and GGM) SUSY breaking, with additional arbitrary soft Higgs mass parameters at the messenger scale. We show that if a gaugino and two first generation sfermion soft masses are determined at the LHC, the RGIs lead to MGM sum rules that yield accurate predictions for the other gaugino and first generation soft masses. RGIs can also be used to reconstruct the fundamental MGM parameters (including the messenger scale), calculate the hypercharge D-term, and find relationships among the third generation and Higgs soft masses. We then study the extent to which measurements of the full first generation spectrum at the LHC may distinguish different SUSY-breaking scenarios. In the case of the MGM model, although most deviations violate the sum rules by more than estimated experimental errors, we find a one-parameter family of GGM models that satisfy the constraints and produce the same first generation spectrum. The GGM-MGM degeneracy is lifted by differences in the third generation masses and the messenger scales.

  20. LHC Predictions from a Tevatron Anomaly in the Top Quark Forward-Backward Asymmetry

    SciTech Connect

    Bai, Yang; Hewett, JoAnne L.; Kaplan, Jared; Rizzo, Thomas G.; /SLAC

    2011-08-12

    We examine the implications of the recent CDF measurement of the top-quark forward-backward asymmetry, focusing on a scenario with a new color octet vector boson at 1-3 TeV. We study several models, as well as a general effective field theory, and determine the parameter space which provides the best simultaneous fit to the CDF asymmetry, the Tevatron top pair production cross section, and the exclusion regions from LHC dijet resonance and contact interaction searches. Flavor constraints on these models are more subtle and less severe than the literature indicates. We find a large region of allowed parameter space at high axigluon mass and a smaller region at low mass; we match the latter to an SU(3){sub 1} x SU(3){sub 2}/SU(3){sub c} coset model with a heavy vector-like fermion. Our scenario produces discoverable effects at the LHC with only 1-2 inverse femtobarns of luminosity at 7-8 TeV. Lastly, we point out that a Tevatron measurement of the b-quark forward-backward asymmetry would be very helpful in characterizing the physics underlying the top-quark asymmetry.

  1. Upgrade of the LHC magnet interconnections thermal shielding

    SciTech Connect

    Musso, Andrea; Barlow, Graeme; Bastard, Alain; Charrondiere, Maryline; Deferne, Guy; Dib, Gaëlle; Duret, Max; Guinchard, Michael; Prin, Hervé; Craen, Arnaud Vande; Villiger, Gilles; Chrul, Anna; Damianoglou, Dimitrios; Strychalski, Michał; Wright, Loren

    2014-01-29

    The about 1700 interconnections (ICs) between the Large Hadron Collider (LHC) superconducting magnets include thermal shielding at 50-75 K, providing continuity to the thermal shielding of the magnet cryostats to reduce the overall radiation heat loads to the 1.9 K helium bath of the magnets. The IC shield, made of aluminum, is conduction-cooled via a welded bridge to the thermal shield of the adjacent magnets which is actively cooled. TIG welding of these bridges made in the LHC tunnel at installation of the magnets induced a considerable risk of fire hazard due to the proximity of the multi-layer insulation of the magnet shields. A fire incident occurred in one of the machine sectors during machine installation, but fortunately with limited consequences thanks to prompt intervention of the operators. LHC is now undergoing a 2 years technical stop during which all magnet's ICs will have to be opened to consolidate the magnet electrical connections. The IC thermal shields will therefore have to be removed and re-installed after the work is completed. In order to eliminate the risk of fire hazard when re-welding, it has been decided to review the design of the IC shields, by replacing the welded bridges with a mechanical clamping which also preserves its thermal function. An additional advantage of this new solution is the ease in dismantling for maintenance, and eliminating weld-grinding operations at removal needing radioprotection measures because of material activation after long-term operation of the LHC. This paper describes the new design of the IC shields and in particular the theoretical and experimental validation of its thermal performance. Furthermore a status report of the on-going upgrade work in the LHC is given.

  2. Upgrade of the LHC magnet interconnections thermal shielding

    NASA Astrophysics Data System (ADS)

    Musso, Andrea; Barlow, Graeme; Bastard, Alain; Charrondiere, Maryline; Chrul, Anna; Damianoglou, Dimitrios; Deferne, Guy; Dib, Gaëlle; Duret, Max; Guinchard, Michael; Prin, Hervé; Strychalski, Michał; Craen, Arnaud Vande; Villiger, Gilles; Wright, Loren

    2014-01-01

    The about 1700 interconnections (ICs) between the Large Hadron Collider (LHC) superconducting magnets include thermal shielding at 50-75 K, providing continuity to the thermal shielding of the magnet cryostats to reduce the overall radiation heat loads to the 1.9 K helium bath of the magnets. The IC shield, made of aluminum, is conduction-cooled via a welded bridge to the thermal shield of the adjacent magnets which is actively cooled. TIG welding of these bridges made in the LHC tunnel at installation of the magnets induced a considerable risk of fire hazard due to the proximity of the multi-layer insulation of the magnet shields. A fire incident occurred in one of the machine sectors during machine installation, but fortunately with limited consequences thanks to prompt intervention of the operators. LHC is now undergoing a 2 years technical stop during which all magnet's ICs will have to be opened to consolidate the magnet electrical connections. The IC thermal shields will therefore have to be removed and re-installed after the work is completed. In order to eliminate the risk of fire hazard when re-welding, it has been decided to review the design of the IC shields, by replacing the welded bridges with a mechanical clamping which also preserves its thermal function. An additional advantage of this new solution is the ease in dismantling for maintenance, and eliminating weld-grinding operations at removal needing radioprotection measures because of material activation after long-term operation of the LHC. This paper describes the new design of the IC shields and in particular the theoretical and experimental validation of its thermal performance. Furthermore a status report of the on-going upgrade work in the LHC is given.

  3. Hadronic flavor violation in pp -> t phi + X and p p -> t t -> bjjc phi +X channels at the LHC

    NASA Astrophysics Data System (ADS)

    Jain, Rishabh; McCoy, Brent; Kao, Chung; Sloan, Jackson

    2017-01-01

    We present a study of flavor changing neutral Higgs interaction in pp -> tϕ0 + X and pp -> t t -> bjjcϕ0 + X , where ϕ0 = h0 or H0 , at the Large Hadron Collider(LHC). We choose a general two Higgs doublet model (2HDM) to study the ghtc couplings with particular emphasis on the ϕ0 -> WW -> lνlν decay channel. With high top production cross section at the LHC,we expect these low background channels to provide a clean signature of flavor changing neutral current among up-type quarks in the Higgs sector and conduct detector simulations to study the visibility and significance of our signal for several values of Higgs masses and the ghtc couplings at the LHC. We include standard model (SM) physics background with realistic acceptance cuts at √{ s} = 13 TeV and 14 TeV. Department of Energy and , OU Supercomputing Center for Education and Reasearch.

  4. Single-Transverse-Spin-Asymmetry studies with a fixed-target experiment using the LHC beams (AFTER@LHC)

    DOE PAGES

    Lansberg, J. P.; Anselmino, M.; Arnaldi, R.; ...

    2016-11-19

    Here we discuss the potential of AFTER@LHC to measure single-transverse-spin asymmetries in open-charm and bottomonium production. With a HERMES-like hydrogen polarised target, such measurements over a year can reach precisions close to the per cent level. This is particularly remarkable since these analyses can probably not be carried out anywhere else.

  5. New Detector Technologies for the LHC Experiments: Prospects, Strategies and Technologies for the HL-LHC Upgrades

    SciTech Connect

    Mannelli, Marcello

    2013-03-06

    We review the prospects, strategies and technologies for the High Luminosity (HL-LHC) upgrades of the ATLAS and CMS detectors, in the light of a very successful two year-long first physics run, and the discovery of a new 126 GeV boson with properties consistent with those of the Standard Model Higgs boson.

  6. Quench protection study of the updated MQXF for the LHC luminosity upgrade (HiLumi LHC)

    DOE PAGES

    Marinozzi, Vittorio; Ambrosio, Giorgio; Ferracin, Paolo; ...

    2016-06-01

    In 2023, the LHC luminosity will be increased, aiming at reaching 3000 fb-1 integrated over ten years. To obtain this target, new Nb3Sn low-β quadrupoles (MQXF) have been designed for the interaction regions. These magnets present a very large aperture (150 mm, to be compared with the 70 mm of the present NbTi quadrupoles) and a very large stored energy density (120 MJ/m3). For these reasons, quench protection is one of the most challenging aspects of the design of these magnets. In fact, protection studies of a previous design showed that the simulated hot spot temperature was very close tomore » the maximum allowed limit of 350 K; this challenge motivated improvements in the current discharge modeling, taking into account the so-called dynamic effects on the apparent magnet inductance. Moreover, quench heaters design has been studied to be going into more details. In this study, a protection study of the updated MQXF is presented, benefiting from the experience gained by studying the previous design. As a result, a study of the voltages between turns in the magnet is also presented during both normal operation and most important failure scenarios.« less

  7. Quench protection study of the updated MQXF for the LHC luminosity upgrade (HiLumi LHC)

    SciTech Connect

    Marinozzi, Vittorio; Ambrosio, Giorgio; Ferracin, Paolo; Izquierdo Bermudez, Susana; Rysti, Juho; Salmi, Tiina; Sorbi, Massimo; Todesco, Ezio

    2016-06-01

    In 2023, the LHC luminosity will be increased, aiming at reaching 3000 fb-1 integrated over ten years. To obtain this target, new Nb3Sn low-β quadrupoles (MQXF) have been designed for the interaction regions. These magnets present a very large aperture (150 mm, to be compared with the 70 mm of the present NbTi quadrupoles) and a very large stored energy density (120 MJ/m3). For these reasons, quench protection is one of the most challenging aspects of the design of these magnets. In fact, protection studies of a previous design showed that the simulated hot spot temperature was very close to the maximum allowed limit of 350 K; this challenge motivated improvements in the current discharge modeling, taking into account the so-called dynamic effects on the apparent magnet inductance. Moreover, quench heaters design has been studied to be going into more details. In this study, a protection study of the updated MQXF is presented, benefiting from the experience gained by studying the previous design. As a result, a study of the voltages between turns in the magnet is also presented during both normal operation and most important failure scenarios.

  8. Quench protection study of the updated MQXF for the LHC luminosity upgrade (HiLumi LHC)

    SciTech Connect

    Marinozzi, Vittorio; Ambrosio, Giorgio; Ferracin, Paolo; Izquierdo Bermudez, Susana; Rysti, Juho; Salmi, Tiina; Sorbi, Massimo; Todesco, Ezio

    2016-06-01

    In 2023, the LHC luminosity will be increased, aiming at reaching 3000 fb-1 integrated over ten years. To obtain this target, new Nb3Sn low-β quadrupoles (MQXF) have been designed for the interaction regions. These magnets present a very large aperture (150 mm, to be compared with the 70 mm of the present NbTi quadrupoles) and a very large stored energy density (120 MJ/m3). For these reasons, quench protection is one of the most challenging aspects of the design of these magnets. In fact, protection studies of a previous design showed that the simulated hot spot temperature was very close to the maximum allowed limit of 350 K; this challenge motivated improvements in the current discharge modeling, taking into account the so-called dynamic effects on the apparent magnet inductance. Moreover, quench heaters design has been studied to be going into more details. In this study, a protection study of the updated MQXF is presented, benefiting from the experience gained by studying the previous design. As a result, a study of the voltages between turns in the magnet is also presented during both normal operation and most important failure scenarios.

  9. Regulation of general amino acid permeases Gap1p, GATA transcription factors Gln3p and Gat1p on 2-phenylethanol biosynthesis via Ehrlich pathway.

    PubMed

    Chen, Xianrui; Wang, Zhaoyue; Guo, Xuena; Liu, Sha; He, Xiuping

    2017-01-20

    In Saccharomyces cerevisiae, when l-phenylalanine (l-Phe) is used as the sole nitrogen source, 2-phenylethanol (PE) is mainly synthesized via the Ehrlich pathway. General amino acid permease Gap1p is response of aromatic amino acids transportation, and GATA transcription factors Gln3p and Gat1p regulate the transcription of permease gene and catabolic enzyme genes for nitrogen sources and aromatic amino acids utilization. In this study, it was demonstrated that over-expressing GLN3 gene from industrial yeast strain MT2 or S. cerevisiae haploid strain YS58, 2-PE synthesis levels of recombinant strains increased 54% or 40% than that of the control strain, which suggested that higher Gln3p activity in yeast has positive regulation effect on 2-PE biosynthesis via Ehrlich pathway. The recombinant strains with over-expression of GAT1 gene from MT2 or YS58 also up-regulated Ehrlich pathway for 2-PE biosynthesis and increased 2-PE production. Similarly, when GAP1 gene respectively from MT2 or YS58 was over-expressed, 2-PE yield was improved obviously, suggesting that GAP1 over-expressing in yeast also promoted Ehrlich pathway to produce 2-PE. The synergistic regulation of GLN3/GAT1 or GLN3/GAP1 over-expression was similar to that of single factor over-expression. Among these regulatory factors, Gln3p of industrial yeast strain MT2 caused stronger regulation on target genes than that of haploid strain YS58, which might be due to the differences in translational efficiency or nuclear localization of each Gln3p, or due to their different spatial structures and binding domains. Further results showed that efficient Gln3p expression in MT2 brought about higher 2-PE, 3.59gL(-1), which was of potential significant for commercial exploitation. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. The First Moment of Azimuthal Anisotropy in Nuclear Collisions from AGS to LHC Energies

    DOE PAGES

    Singha, Subhash; Shanmuganathan, Prashanth; Keane, Declan

    2016-10-01

    We reviewmore » topics related to the first moment of azimuthal anisotropy (v1), commonly known as directed flow, focusing on both charged particles and identified particles from heavy-ion collisions. Beam energies from the highest available, at the CERN LHC, down to projectile kinetic energies per nucleon of a few GeV per nucleon, as studied in experiments at the Brookhaven AGS, fall within our scope. We focus on experimental measurements and on theoretical work where direct comparisons with experiment have been emphasized. The physics addressed or potentially addressed by this review topic includes the study of Quark Gluon Plasma and, more generally, investigation of the Quantum Chromodynamics phase diagram and the equation of state describing the accessible phases.« less

  11. Open charm meson analysis in proton-proton collisions at the LHC with ALICE

    NASA Astrophysics Data System (ADS)

    Ortona, G.

    2010-06-01

    The extremely high energies that will be reached with the Large Hadron Collider (LHC) at CERN will allow studying the production of open charm with high statistics in both proton-proton and Pb-Pb collisions. The study of open charm (D) mesons in Pb-Pb collisions will be a powerful tool to investigate the production of heavy flavours and their interaction with the medium produced in such collisions (QGP). Heavy flavour yields will provide also a normalization for quarkonia production. We will present a general overview of the ALICE collaboration heavy flavour program, then we will focus on the analysis and reconstruction strategies developed for the study of the charmed (D) mesons by the ALICE collaboration for proton-proton collisions, with special emphasis on the charged D mesons. Finally, some expected results obtained with MonteCarlo production will be shown.

  12. Kaluza-Klein Dark Matter: Direct Detection vis-a-vis LHC (2013 update)

    SciTech Connect

    Arrenberg, Sebastian; Baudis, Laura; Kong, Kyoungchul; Matchev, Konstantin T.; Yoo, Jonghee

    2013-07-24

    We present updated results on the complementarity between high-energy colliders and dark matter direct detection experiments in the context of Universal Extra Dimensions (UED). In models with relatively small mass splittings between the dark matter candidate and the rest of the (colored) spectrum, the collider sensitivity is diminished, but direct detection rates are enhanced. UED provide a natural framework to study such mass degeneracies. We discuss the detection prospects for the KK photon $\\gamma_1$ and the KK $Z$-boson $Z_1$, combining the expected LHC reach with cosmological constraints from WMAP/Planck, and the sensitivity of current or planned direct detection experiments. Allowing for general mass splittings, neither colliders, nor direct detection experiments by themselves can explore all of the relevant KK dark matter parameter space. Nevertheless, they probe different parameter space regions, and the combination of the two types of constraints can be quite powerful.

  13. Right-handed neutrinos at CERN LHC and the mechanism of neutrino mass generation

    SciTech Connect

    Kersten, Joern; Smirnov, Alexei Yu.

    2007-10-01

    We consider the possibility to detect right-handed neutrinos, which are mostly singlets of the standard model gauge group, at future accelerators. Substantial mixing of these neutrinos with the active neutrinos requires a cancellation of different contributions to the light neutrino mass matrix at the level of 10{sup -8}. We discuss possible symmetries behind this cancellation and argue that for three right-handed neutrinos they always lead to conservation of total lepton number. Light neutrino masses can be generated by small perturbations violating these symmetries. In the most general case, LHC physics and the mechanism of neutrino mass generation are essentially decoupled; with additional assumptions, correlations can appear between collider observables and features of the neutrino mass matrix.

  14. The First Moment of Azimuthal Anisotropy in Nuclear Collisions from AGS to LHC Energies

    SciTech Connect

    Singha, Subhash; Shanmuganathan, Prashanth; Keane, Declan

    2016-10-01

    We review topics related to the first moment of azimuthal anisotropy (v1), commonly known as directed flow, focusing on both charged particles and identified particles from heavy-ion collisions. Beam energies from the highest available, at the CERN LHC, down to projectile kinetic energies per nucleon of a few GeV per nucleon, as studied in experiments at the Brookhaven AGS, fall within our scope. We focus on experimental measurements and on theoretical work where direct comparisons with experiment have been emphasized. The physics addressed or potentially addressed by this review topic includes the study of Quark Gluon Plasma and, more generally, investigation of the Quantum Chromodynamics phase diagram and the equation of state describing the accessible phases.

  15. 4D fast tracking for experiments at high luminosity LHC

    NASA Astrophysics Data System (ADS)

    Neri, N.; Cardini, A.; Calabrese, R.; Fiorini, M.; Luppi, E.; Marconi, U.; Petruzzo, M.

    2016-11-01

    The full exploitation of the physics potential of the high luminosity LHC is a big challenge that requires new instrumentation and innovative solutions. We present here a conceptual design and simulation studies of a fast timing pixel detector with embedded real-time tracking capabilities. The system is conceived to operate at 40 MHz event rate and to reconstruct tracks in real-time, using precise space and time 4D information of the hit, for fast trigger decisions. This work is part of an R&D project aimed at building an innovative tracking detector with superior time (10 ps) and position (10 μm) resolutions to be used in very harsh radiation environments, for the ultimate flavour physics experiment at the high luminosity phase of the LHC.

  16. Probing composite models at the LHC with exotic quarks production

    NASA Astrophysics Data System (ADS)

    Kukla, Romain

    2017-03-01

    After the Higgs boson hunt, the LHC could be a powerful tool to unravel the mystery of which physics lies beyond the realm of the Standard Model. Different new sectors have been postulated to address naturalness: SUSY, extra dimensions and strong dynamics theories. Composite models extend EWSB to a global symmetry breaking whose pseudo-Goldstone boson is the SM Higgs boson. The resulting mass spectrum originates from a partial mixing between fundamental fermions and composite fields which creates massive states including new heavy quarks coupled preferentially to the top quark. Searches for these top partners have been carried out by the ATLAS and CMS collaborations, constraining the models. Other composite contributions are expected to enhance the 4-top production, which should be observable in the next years at the LHC.

  17. VII Workshop Italiano sulla fisica pp a LHC

    NASA Astrophysics Data System (ADS)

    LHCpp2016 è la settima edizione dell'incontro nazionale sulla fisica p-p a LHC. Questa serie di incontri è nata a Pisa nel 2003 con lo scopo di stimolare lo scambio di idee tra le comunità sperimentali di ATLAS, CMS e LHCB e la comunità teorica. Caratteristica fondamentale di questi incontri è la preparazione di larga parte dei talk in collaborazione tra i vari esperimenti e la comunità teorica. Largo spazio nella preparazione e presentazione dei talk viene dato ai giovani ricercatori. In questa settima edizione, che si tiene di nuovo a Pisa, vogliamo concentrare l'attenzione sulle potenzialità di scoperta offerte dai dati raccolti durante il runII di LHC.

  18. Test results of LHC interaction regions quadrupoles produced by Fermilab

    SciTech Connect

    Bossert, R.; Carson, J.; Chichili, D.R.; Feher, S.; Kerby, J.; Lamm, M.J.; Nobrega, A.; Nicol, T.; Ogitsu, T.; Orris, D.; Page, T.; Peterson, T.; Rabehl, R.; Robotham, W.; Scanlan, R.; Schlabach, P.; Sylvester, C.; Strait, J.; Tartaglia, M.; Tompkins, J.C.; Velev, G.; /Fermilab

    2004-10-01

    The US-LHC Accelerator Project is responsible for the production of the Q2 optical elements of the final focus triplets in the LHC interaction regions. As part of this program Fermilab is in the process of manufacturing and testing cryostat assemblies (LQXB) containing two identical quadrupoles (MQXB) with a dipole corrector between them. The 5.5 m long Fermilab designed MQXB have a 70 mm aperture and operate in superfluid helium at 1.9 K with a peak field gradient of 215 T/m. This paper summarizes the test results of several production MQXB quadrupoles with emphasis on quench performance and alignment studies. Quench localization studies using quench antenna signals are also presented.

  19. Charged Higgs Probes of Dark Bosons at the LHC

    SciTech Connect

    Kong, Kyoungchul; Lee, Hye-Sung; Park, Myeonghun

    2014-08-01

    A very light (GeV scale) dark gauge boson (Z') is a recently highlighted hypothetical particle that can address some astrophysical anomalies as well as the 3.6σ deviation in the muon g-2 measurement. We suggest top quark decays as a venue to search for light dark force carriers at the LHC. Such Z's can be easily boosted, and they can decay into highly collimated leptons (lepton-jet) with large branching ratio. We investigate a scenario where a top quark decays to bW accompanied by one or multiple dark force carriers and find that such a scenario could be easily probed at the early stage of LHC Run 2.

  20. Heat Exchanger Design Studies for AN Lhc Inner Triplet Upgrade

    NASA Astrophysics Data System (ADS)

    Rabehl, R. J.; Huang, Y.

    2008-03-01

    A luminosity upgrade of the CERN Large Hadron Collider (LHC) is planned to coincide with the expected end of life of the existing inner triplet quadrupole magnets. The upgraded inner triplet will have much larger heat loads to be removed from the magnets by the cryogenics system. A number of cryogenics design studies have been completed under the LHC Accelerator Research Program (LARP), including investigations of required heat exchanger characteristics to transfer this heat from the pressurized He II bath to the saturated He II system. This paper discusses heat exchangers both external to the magnet cold mass and internal to the magnet cold mass. A possible design for a heat exchanger external to the magnet cold mass is also presented.

  1. Proton-proton hollowness at the LHC from inverse scattering

    NASA Astrophysics Data System (ADS)

    Arriola, Enrique Ruiz; Broniowski, Wojciech

    2017-04-01

    Parametrizations of the pp scattering data at the LHC collision energies indicate a hollow in the inelasticity profile of the pp interaction, with less absorption for head-on collisions than at a nonzero impact parameter. We show that some qualitatively unnoticed features may be unveiled by a judicious application of the inverse scattering problem in the eikonal approximation and interpretation within an optical potential model. The hollowness effect is magnified in a 3D picture of the optical potential, and will presumably be enhanced at yet higher energies. Moreover, in 3D it sets in at much smaller energies than at the LHC. We argue that hollowness in the impact parameter is a quantum effect, relying on the build-up of the real part of the eikonal scattering phase and its possible passage through π /2 . We also show that it precludes models of inelastic collisions where inelasticity is obtained by naive folding of partonic densities.

  2. Broad-Band Impedance of LHC Shielded Bellows

    NASA Astrophysics Data System (ADS)

    D'Yachkov, M.; Ruggiero, F.

    1997-05-01

    To compensate for thermal expansion the LHC ring has to accommodate about 3000 bellows which together with beam position monitors are the biggest contributors to the LHC broad-band impedance budget. In order to reduce this impedance to an acceptable value the bellows have to be shielded. In this paper we compare different designs proposed for the bellows and calculate their transverse and longitudinal wake fields and impedances. Due to the 3D geometry of the bellows MAFIA was used for the wake-field calculations; when possible the MAFIA results were compared with those obtained with ABCI. The results presented in this paper indicate that two designs for the bellows in which shielding is provided by using sprung fingers which can slide along the beam screens both have acceptable impedances, but one design may be preferable to the other from mechanical considerations. Several failure modes such as missing fingers and imperfect rf contact have also been studied.

  3. Observing the top energy asymmetry at the LHC

    NASA Astrophysics Data System (ADS)

    Berge, S.; Westhoff, S.

    2017-01-01

    The top-antitop energy asymmetry is a promising observable of the charge asymmetry in jet-associated top-quark pair production at the LHC. We present new predictions of the energy asymmetry in proton-proton collisions at 13 TeV, including QCD corrections at the next-to-leading perturbative order. The effect of QCD corrections on the observable is moderate. With suitable phase-space cuts, the asymmetry can be enhanced at the cost of reducing the cross section. For instance, for a cross section of 1 pb after cuts, we predict an energy asymmetry of -6. 5-0.2+0.1% at the next-to-leading order in QCD. We also investigate scale uncertainties and parton-shower effects, which partially cancel in the normalized asymmetry. Our results provide a sound basis for a measurement of the energy asymmetry at the LHC during run II.

  4. CMS Pixel Detector design for HL-LHC

    NASA Astrophysics Data System (ADS)

    Migliore, E.

    2016-12-01

    The LHC machine is planning an upgrade program which will smoothly bring the luminosity to about 7.5×1034cm-2s-1 in 2028, to possibly reach an integrated luminosity of 3000 fb-1 by the end of 2037. This High Luminosity scenario, HL-LHC, will present new challenges in higher data rates and increased radiation. In order to maintain its physics reach the CMS collaboration has undertaken a preparation program of the detector known as Phase-2 upgrade. The CMS Phase-2 Pixel upgrade will require a high bandwidth readout system and high radiation tolerance for sensors and on-detector ASICs. Several technologies for the upgrade sensors are being studied. Serial powering schemes are under consideration to accommodate significant constraints on the system. These prospective designs, as well as new layout geometries that include very forward pixel discs, will be presented together with performance estimation.

  5. The LHC Inverse Problem, Supersymmetry and the ILC

    SciTech Connect

    Berger, C.F.; Gainer, J.S.; Hewett, J.L.; Lillie, B.; Rizzo, T.G.

    2007-11-12

    We address the question whether the ILC can resolve the LHC Inverse Problem within the framework of the MSSM. We examine 242 points in the MSSM parameter space which were generated at random and were found to give indistinguishable signatures at the LHC. After a realistic simulation including full Standard Model backgrounds and a fast detector simulation, we find that roughly only one third of these scenarios lead to visible signatures of some kind with a significance {ge} 5 at the ILC with {radical}s = 500 GeV. Furthermore, we examine these points in parameter space pairwise and find that only one third of the pairs are distinguishable at the ILC at 5{sigma}.

  6. Finding the strong CP problem at the LHC

    NASA Astrophysics Data System (ADS)

    D'Agnolo, Raffaele Tito; Hook, Anson

    2016-11-01

    We show that a class of parity based solutions to the strong CP problem predicts new colored particles with mass at the TeV scale, due to constraints from Planck suppressed operators. The new particles are copies of the Standard Model quarks and leptons. The new quarks can be produced at the LHC and are either collider stable or decay into Standard Model quarks through a Higgs, a W or a Z boson. We discuss some simple but generic predictions of the models for the LHC and find signatures not related to the traditional solutions of the hierarchy problem. We thus provide alternative motivation for new physics searches at the weak scale. We also briefly discuss the cosmological history of these models and how to obtain successful baryogenesis.

  7. Current LHC constraints on minimal universal extra dimensions

    NASA Astrophysics Data System (ADS)

    Deutschmann, Nicolas; Flacke, Thomas; Kim, Jong Soo

    2017-08-01

    In this letter, we present LHC limits on the minimal universal extra dimension (MUED) model from LHC Run 1 data and current limits from searches of the ongoing Run 2. Typical collider signals of the Kaluza-Klein (KK) states mimic generic degenerate supersymmetry (SUSY) missing transverse momentum signatures since the KK particles cascade decay into jets, leptons and the lightest KK particle which is stable due to KK parity and evades detection. We test the parameter space against a large number of supersymmetry based missing energy searches implemented in the public code CheckMATE. We demonstrate the complementarity of employing various searches which target a large number of final state signatures, and we derive the most up to date limits on the MUED parameter space from 13 TeV SUSY searches.

  8. High Speed Measurements of the LHC Luminosity Monitor

    NASA Astrophysics Data System (ADS)

    Beche, J. F.; Byrd, J. M.; Monroy, M.; Ratti, A.; Turner, W.; Bravin, E.

    2006-11-01

    The LHC luminosity monitor is a gas ionization chamber designed to operate in the high radiation environment present in the TAN neutral absorbers at the LHC. One of the challenges is to measure the luminosity of individual bunch crossings with a minimum separation of 25 nsec. To test the time response and other aspects of a prototype chamber, we have performed a test using an x-ray beam of 40-60 keV with pulse spacing of 26 nsec as an ionizing beam. The tests were made at BL 8.3.2 at the Advanced Light Source (ALS). This work was supported by the Director, Office of Science, Office of High Energy Physics, of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231.

  9. Signals of Warped Extra Dimensions at the LHC

    SciTech Connect

    Osland, P.; Pankov, A. A.; Tsytrinov, A. V.; Paver, N.

    2010-12-22

    We discuss the signatures of the spin-2 graviton excitations predicted by the Randall-Sundrum model with one warped extra dimension, in dilepton and diphoton production at LHC. By using a specific angular analysis, we assess the ranges in mass and coupling constant where such gravitons can be discriminated against competitor spin-1 and spin-0 objects, that potentially could manifest themselves in these processes with the same mass and rate of events. Depending on the value of the coupling constant to quarks and leptons, the numerical results indicate graviton identification mass ranges up to 1.1-2.4 TeV and 1.6-3.2 TeV for LHC nominal energy of 14 TeV and time-integrated luminosity of 10 and 100fb{sup -1}, respectively.

  10. Augmented reality aiding collimator exchange at the LHC

    NASA Astrophysics Data System (ADS)

    Martínez, Héctor; Fabry, Thomas; Laukkanen, Seppo; Mattila, Jouni; Tabourot, Laurent

    2014-11-01

    Novel Augmented Reality techniques have the potential to have a large positive impact on the way remote maintenance operations are carried out in hazardous areas, e.g. areas where radiation doses that imply careful planning and optimization of maintenance operations are present. This paper describes an Augmented Reality strategy, system and implementation for aiding the remote collimator exchange in the LHC, currently the world's largest and highest-energy particle accelerator. The proposed system relies on marker detection and multi-modal augmentation in real-time. A database system has been used to ensure flexibility. The system has been tested in a mock-up facility, showing real time performance and great potential for future use in the LHC. The technical-scientific difficulties identified during the development of the system and the proposed solutions described in this paper may help the development of future Augmented Reality systems for remote handling in scientific facilities.

  11. Vector resonances at LHC Run II in composite 2HDM

    NASA Astrophysics Data System (ADS)

    Di Chiara, Stefano; Heikinheimo, Matti; Tuominen, Kimmo

    2017-03-01

    We consider a model where the electroweak symmetry breaking is driven by strong dynamics, resulting in an electroweak doublet scalar condensate, and transmitted to the standard model matter fields via another electroweak doublet scalar. At low energies the effective theory therefore shares features with a type-I two Higgs doublet model. However, important differences arise due to the rich composite spectrum expected to contain new vector resonances accessible at the LHC. We carry out a systematic analysis of the vector resonance signals at LHC and find that the model remains viable, but will be tightly constrained by direct searches as the projected integrated luminosity, around 200 fb-1, of the current run becomes available.

  12. CP asymmetries in the supersymmetric trilepton signal at the LHC

    NASA Astrophysics Data System (ADS)

    Bornhauser, S.; Drees, M.; Dreiner, H.; Éboli, O. J. P.; Kim, J. S.; Kittel, O.

    2012-03-01

    In the CP-violating Minimal Supersymmetric Standard Model, we study the production of a neutralino-chargino pair at the LHC. For their decays into three leptons, we analyze CP asymmetries which are sensitive to the CP phases of the neutralino and chargino sector. We present analytical formulas for the entire production and decay process, and identify the CP-violating contributions in the spin correlation terms. This allows us to define the optimal CP asymmetries. We present a detailed numerical analysis of the cross sections, branching ratios, and the CP observables. For light neutralinos, charginos, and squarks, the asymmetries can reach several 10%. We estimate the discovery potential for the LHC to observe CP violation in the trilepton channel.

  13. LHC Olympics Workshop and String Phenomenology 2006 Conference

    SciTech Connect

    David Gross

    2006-10-01

    This is the final report of the organizers of the String Phenomenolgy program of which the LHC Olympics and the String Phenomenolgy conference were a part. In addition, it includes the list of talks from our website which comprise the online proceedings. The KITP no longer publishes conferences proceedings but rather makes recordings and visuals of all talks available on its website at www.kitp.ucsb.edu Program talks are available at http://online.kitp.ucsb.edu/online/strings06/ Conference talks are are at http://online.itp.ucsb.edu/online/strings_c06/ and LHC Olympics talks are at http://online.itp.ucsb.edu/online/lhco_c06/. These talks constitute the proceedings of these meetings.

  14. LHC beam-beam compensation studies at RHIC

    SciTech Connect

    Fischer,W.; Abreu, N.; Calaga, R.; Robert-Demolaize, G.; Luo, Y.; Montag, C.

    2009-05-04

    Long-range and head-on beam-beam effects are expected to limit the LHC performance with design parameters. To mitigate long-range effects current carrying wires parallel to the beam were proposed. Two such wires are installed in RHIC where they allow studying the effect of strong long-range beam-beam effects, as well as the compensation of a single long-range interaction. The tests provide benchmark data for simulations and analytical treatments. To reduce the head-on beam-beam effect electron lenses were proposed for both the LHC and RHIC. We present the experimental long-range beam-beam program and report on head-on compensations studies at RHIC, which are based on simulations.

  15. Nuclear effects in squark production at the LHC

    SciTech Connect

    Espindola, Danusa B.; Mariotto, C. B.; Rodriguez, M. C.

    2013-03-25

    In this contribution we study the production of squarks. If squarks are found in proton-proton (pp) collisions at the LHC, they might also be produced in collisions involving nuclei (pA and AA collisions). Here we investigate the influence of nuclear effects in the production of squarks in nuclear collisions at the LHC, and estimate the transverse momentum dependence of the nuclear ratios R{sub pA} = (d{sigma}(pA)/d{sub pT})/A(d{sigma}(pp)/d{sub pT}) and R{sub AA} = (d{sigma}(AA)/d{sub pT})/A{sup 2}(d{sigma}(pp)/d{sub pT}). We demonstrate that depending on the magnitude of the nuclear effects, the production of squarks could be enhanced or suppressed, compared to proton-proton collisions at same energies.

  16. The LHC Higgs boson discovery: Implications for Finite Unified Theories

    NASA Astrophysics Data System (ADS)

    Heinemeyer, S.; Mondragón, M.; Zoupanos, G.

    2014-06-01

    Finite Unified Theories (FUTs) are N = 1 supersymmetric Grand Unified Theories (GUTs) which can be made finite to all-loop orders, based on the principle of reduction of couplings, and therefore are provided with a large predictive power. We confront the predictions of an SU(5) FUT with the top and bottom quark masses and other low-energy experimental constraints, resulting in a relatively heavy SUSY spectrum, naturally consistent with the nonobservation of those particles at the LHC. The light Higgs boson mass is automatically predicted in the range compatible with the Higgs discovery at the LHC. Requiring a light Higgs boson mass in the precise range of Mh = 125.6 ±2.1 GeV favors the lower part of the allowed spectrum, resulting in clear predictions for the discovery potential at current and future pp, as well as future e+e- colliders.

  17. Falsifying high-scale leptogenesis at the LHC.

    PubMed

    Deppisch, Frank F; Harz, Julia; Hirsch, Martin

    2014-06-06

    Measuring a nonzero value for the cross section of any lepton number violating (LNV) process would put a strong lower limit on the washout factor for the effective lepton number density in the early Universe at times close to the electroweak phase transition and thus would lead to important constraints on any high-scale model for the generation of the observed baryon asymmetry based on LNV. In particular, for leptogenesis (LG) models with masses of the right-handed neutrinos heavier than the mass scale observed at the LHC, the implied large washout factors would lead to a violation of the out-of-equilibrium condition and exponentially suppress the net lepton number produced in such LG models. We thus demonstrate that the observation of LNV processes at the LHC results in the falsification of high-scale LG models. However, no conclusions about the viability of LG models can be drawn from the nonobservation of LNV processes.

  18. Optics Studies of the LHC Beam Transfer Line TI8

    SciTech Connect

    J. Wenninger; G. Arduini; B. Goddard; D. Jacquet; V. Kain; M. Lamont; V. Mertens; J.A. Uythoven; Y.-C. Chao

    2005-05-16

    The optics of the newly commissioned LHC beam transfer line TI 8 was studied with beam trajectories, dispersion and profile measurements. Steering magnet response measurements were used to analyze the quality of the steering magnets and of the beam position monitors. A simultaneous fit of the quadrupole strengths was used to search for setting or calibration errors. Residual coupling between the planes was evaluated using high statistics samples of trajectories. Initial conditions for the optics at the entrance of the transfer line were reconstructed from beam profile measurements with Optical Transition Radiation monitors. The paper presents the various analysis methods and their errors. The expected emittance growth arising from optical mismatch into the LHC is evaluated.

  19. Single and double diffraction dissociation at the LHC

    NASA Astrophysics Data System (ADS)

    Fiore, Roberto; Jenkovszky, László; Mieskolainen, Mikael; Orava, Risto

    2017-03-01

    Single and double diffraction dissociation at the LHC is studied in a factorizable Regge-pole model, dominated by a Pomeron pole exchange in the t channel. While the contribution from secondary reggeon exchanges at the LHC is negligible, they are indispensable to match the lower-energy, ISR and FNAL data. To this end we append to the leading Pomeron exchange an effective reggeon. The main emphasis in our study is on the nucleon resonances in missing masses, that are accounted for by a dual model of the inelastic pP → MX vertex, similar to the DIS structure function, known from HERA, with a non-linear nucleon, N∗ trajectory in the direct, MX2 channel. Regge factorization and its breakdown due to a renormalization factor, tempering the energy rise is discussed.

  20. LHC diphoton Higgs signal predicted by little Higgs models

    SciTech Connect

    Wang Lei; Yang Jinmin

    2011-10-01

    Little Higgs theory naturally predicts a light Higgs boson whose most important discovery channel at the LHC is the diphoton signal pp{yields}h{yields}{gamma}{gamma}. In this work, we perform a comparative study for this signal in some typical little Higgs models, namely, the littlest Higgs model, two littlest Higgs models with T-parity (named LHT-I and LHT-II), and the simplest little Higgs models. We find that compared with the standard model prediction, the diphoton signal rate is always suppressed and the suppression extent can be quite different for different models. The suppression is mild (< or approx. 10%) in the littlest Higgs model but can be quite severe ({approx_equal}90%) in other three models. This means that discovering the light Higgs boson predicted by the little Higgs theory through the diphoton channel at the LHC will be more difficult than discovering the standard model Higgs boson.