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Sample records for lhmus lars briggs

  1. "The Snowman" by Raymond Briggs.

    ERIC Educational Resources Information Center

    Brodie, Carolyn S.

    2003-01-01

    Discusses the classic children's book "The Snowman," by Raymond Briggs, and lists connections to the book in different formats; extension ideas; other picture books that feature snow; information books about snow; videos; a CD-ROM; Web sites related to the book; and Web sites with information about snow. (LRW)

  2. "The Snowman" by Raymond Briggs.

    ERIC Educational Resources Information Center

    Brodie, Carolyn S.

    2003-01-01

    Discusses the classic children's book "The Snowman," by Raymond Briggs, and lists connections to the book in different formats; extension ideas; other picture books that feature snow; information books about snow; videos; a CD-ROM; Web sites related to the book; and Web sites with information about snow. (LRW)

  3. Lars, the Oracle

    NASA Astrophysics Data System (ADS)

    Careri, Giorgio

    Lars Onsager was known for his obscure but correct predictions in several fields of science. Some scientific events, particularly in the field of superfluidity, are recollected here by one of his old friends.

  4. Myers-Briggs typology and Jungian individuation.

    PubMed

    Myers, Steve

    2016-06-01

    Myers-Briggs typology is widely seen as equivalent to and representative of Jungian theory by the users of the Myers-Briggs Type Indicator (MBTI) and similar questionnaires. However, the omission of the transcendent function from the theory, and the use of typological functions as its foundation, has resulted in an inadvertent reframing of the process of individuation. This is despite some attempts to integrate individuation and typology, and reintroduce the transcendent function into Myers-Briggs theory. This paper examines the differing views of individuation in Myers-Briggs and Jungian theory, and some of the challenges of reconciling those differences, particularly in the context of normality. It proposes eight principles, drawn mainly from Jungian and classical post-Jungian work, that show how individuation as a process can be integrated with contemporary Myers-Briggs typology. These principles show individuation as being a natural process that can be encouraged outside of the analytic process. They make use of a wide range of opposites as well as typological functions, whilst being centred on the transcendent function. Central to the process is the alchemical image of the caduceus and a practical interpretation of the axiom of Maria, both of which Jung used to illustrate the process of individuation. © 2016, The Society of Analytical Psychology.

  5. The Myers-Briggs Type of College Student Leaders.

    ERIC Educational Resources Information Center

    Darst, Kimberly Vess

    2001-01-01

    Determined the Myers-Briggs type for 149 undergraduate students holding leadership positions in student organizations. Found that college student leaders tent to be Extraverted, Sensing, Thinking, and Judging on the Myers-Briggs Type Indicator. (EV)

  6. The Myers-Briggs Type of College Student Leaders.

    ERIC Educational Resources Information Center

    Darst, Kimberly Vess

    2001-01-01

    Determined the Myers-Briggs type for 149 undergraduate students holding leadership positions in student organizations. Found that college student leaders tent to be Extraverted, Sensing, Thinking, and Judging on the Myers-Briggs Type Indicator. (EV)

  7. 75 FR 10318 - Briggs & Stratton Power Products Group, LLC., Home Power Division, a Subsidiary of Briggs...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-05

    ..., Schweiger Warehouse, a Subsidiary of Briggs & Stratton Corporation Including On-Site Leased Workers of... the subject firm; Schweiger Warehouse, Jefferson, Wisconsin and the Watertown, Wisconsin locations. Accordingly, the Department is amending the certification to include workers of the Schweiger...

  8. GMRT HI Imaging of Selected LARS+eLARS Galaxies

    NASA Astrophysics Data System (ADS)

    Perez Sarmiento, Karen; Mendoza Davila, Cesar I.; Cannon, John M.; Hayes, Matthew; Melinder, Jens; Östlin, Göran; Pardy, Stephen; LARS Team

    2017-01-01

    The Lyman Alpha Reference Sample (LARS) and its extension (eLARS) form the most comprehensive effort to date to study the details of Lyman Alpha radiative transfer in galaxies. Direct imaging of Lyman Alpha emission from the Hubble Space Telescope is supplemented by a wealth of multi-wavelength observations designed to probe the complex processes that contribute to the escape or destruction of Lyman Alpha photons as they resonantly scatter in the neutral ISM. The 42 LARS+eLARS galaxies span a range of physical properties, including mass and star formation rate. In this work, we present new GMRT HI imaging of selected LARS+eLARS galaxies designed to study the detailed morphology and kinematics of the HI gas. HI column density images and velocity fields are compared to SDSS imaging.

  9. Using the Myers Briggs Type Indicator - part of the solution.

    PubMed

    Allen, Judy

    1994-05-12

    The Myers Briggs Type Indicator, which is based on the work of Jung, is used in an infinite variety of settings to enhance learning, personal development and team building. This article describes its particular relevance to the nursing profession. (N.B. Isabel Myers used the name Isabel Briggs Myers for publication purposes. The Indicator is termed Myers Briggs in order to indicate the involvement of her mother in its development.).

  10. Dr. William Briggs: ophthalmic physician at St. Thomas' Hospital, London.

    PubMed

    Winstanley, J

    2001-01-01

    William Briggs, MD, established himself as one of the first ophthalmic physicians, whom today we would call a neuro-ophthalmologist, to practice in the United Kingdom. After graduating with an MD from Cambridge in 1677, and while a Fellow of Corpus Christi College, he carried out original studies in visual anatomy and physiology. He described and named the optic papilla and the retinal nerve fibers in his book Ophthalmographia, published in 1676. He published his New Theory of Vision in 1682. While at Cambridge, he was a contemporary and a friend of Isaac Newton, with whom Briggs worked but who, in matters of visual anatomy and physiology, came to reach different conclusions from Briggs. In 1683, Briggs came to London to practice as a physician at St. Thomas' Hospital, where he established a considerable reputation as an ophthalmologist. For political reasons he was forced to resign from the Hospital prematurely.

  11. Joanna Briggs Institute: an evidence-based practice database.

    PubMed

    Vardell, Emily; Malloy, Michele

    2013-01-01

    The Joanna Briggs Institute Evidence-Based Practice Database offers systematic reviews, practice recommendations, and consumer information designed to support evidence-based practice. A sample search was conducted within the Ovid platform to demonstrate functionality and available tools.

  12. Lar gibbon (Hylobates lar) great call reveals individual caller identity.

    PubMed

    Terleph, Thomas A; Malaivijitnond, S; Reichard, U H

    2015-07-01

    Gibbons (family Hylobatidae) produce loud, elaborate vocalizations (songs), often in well-coordinated male/female duets. The female's great call, the most conspicuous phrase of the gibbon vocal repertoire, functions primarily to mediate territorial defense. Despite the fact that lar gibbons (Hylobates lar) are the most widely distributed and well researched hylobatid species and produce a rich vocal repertoire, the individual-specificity of their great calls has not previously been quantified. In addition, spectral and temporal features of notes occurring at specific locations within the lar great call have not been described. Here we provide such a description, and test the hypothesis that great calls are statistically discriminable between a large sample of individual callers. We compared recordings of great calls from 14 wild lar females in Khao Yai National Park, Thailand. Our analyses of principal components derived from spectral and temporal measures, as well as spectrograms from the entire great call, indicate that acoustic variation is sufficient to allow identification of individual callers (83.5% discriminability based on principal components, and inter-individual call variation exceeding intra-individual variation in overall spectrogram). These vocalizations potentially allow individual recognition of animals. © 2015 Wiley Periodicals, Inc.

  13. One legacy of Lord Briggs is the value placed on nurse research.

    PubMed

    Adams, John

    2016-03-23

    The announcement of the death of Asa Briggs - Lord Briggs of Lewes - on March 15 brings to mind the debt the nursing profession owes his wise stewardship of a committee that examined aspects of the profession.

  14. The life and scientific contributions of Lyman J. Briggs

    USGS Publications Warehouse

    Landa, Edward R.; Nimmo, John R.

    2003-01-01

    Lyman J. Briggs (1874-1963), an early twentieth century physicist at the U. S. Department of Agriculture (USDA), made many significant contributions to our understanding of soil-water and plant-water interactions. He began his career at the Bureau of Soils (BOS) in 1896. At age 23, Briggs published (1897) a description of the roles of surface tension and gravity in determining the state of static soilmoisture. Concepts he presented remain central to this subject more than 100 yr later. With J. W. McLane, Briggs developed the "moisture equivalent" concept (a precursor to the idea of field capacity) and a centrifuge apparatus for measuring it. Briggs left the BOS at the end of 1905, under pressure from Milton Whitney, and moved to the Bureau of Plant Industry. Briggs' multi-state experiments with H. L. Shantz on water-use efficiencies showed that in a climate like that of the Great Plains, plants use water more productively in the cooler north than in the warmer south. In 1920, he moved from the USDA to the National Bureau of Standards (NBS), rising to Director in 1933. Among his other contributions to the American scientific community was his leadership, beginning in 1939, of a top secret committee that evolved into the Manhattan Project to develop an atomic bomb during World War II. A life-long baseball fan, Briggs at age 84, studied the speed, spin, and deflection of the curve ball, aided by manager Cookie Lavagetto and the pitching staff of the Washington Senators; he published these findings in a paper in the American Journal of Physics in 1959.

  15. An assessment of the Myers-Briggs Type indicator.

    PubMed

    Carlyn, M

    1977-10-01

    A comprehensive assessment of the Myers-Briggs Type indicator is presented, including a description of the four personality scales measured by the instrument, a summary of the scoring process, and an extensive review of intercorrelation studies, reliability studies, and validity studies conducted with the Indicator. Results of the studies indicate that the Myers-Briggs Type Indicator is an adequately reliable self-report inventory. The Extraversion-Introversion Sensation-Intuition, and Thinking-Feeling scales appear to be relatively independent of each other, measuring dimensions of personality which seem to be quite similar to those postulated by Carl Jung.

  16. Myers-Briggs Type Inventory Personality Preferences and Academic Performance.

    ERIC Educational Resources Information Center

    Lowenthal, Werner; Meth, Hilda

    1989-01-01

    A study to determine if there are any relationships between the Myers-Briggs Type Inventory personality preferences and academic performance in schools of pharmacy is discussed. Differences in academic performance that could be related to gender are reported. (Author/MLW)

  17. Myers-Briggs Type Inventory Personality Preferences and Academic Performance.

    ERIC Educational Resources Information Center

    Lowenthal, Werner; Meth, Hilda

    1989-01-01

    A study to determine if there are any relationships between the Myers-Briggs Type Inventory personality preferences and academic performance in schools of pharmacy is discussed. Differences in academic performance that could be related to gender are reported. (Author/MLW)

  18. Credible Immigration Policy Reform: A Response to Briggs

    ERIC Educational Resources Information Center

    Orrenius, Pia M.; Zavodny, Madeline

    2012-01-01

    The authors agree with Vernon M. Briggs, Jr., that U.S. immigration policy has had unexpected consequences. The 1965 immigration reforms led to unanticipated chain migration from developing countries whereas the 1986 Immigration Reform and Control Act failed to slow unauthorized immigration. The result is a large foreign-born population with…

  19. An Assessment of the Myers-Briggs Type Indicator

    ERIC Educational Resources Information Center

    Carlyn, Marcia

    1977-01-01

    The Myers Briggs Type Indicator is a self-report inventory developed to measure variables in Carl Jung's personality typology. The four personality scales measured by the instrument, and the scoring process are described, and an extensive review of the intercorrelation, reliability, and validity research is presented. (Author/MV)

  20. The Utility of the Myers-Briggs Type Indicator.

    ERIC Educational Resources Information Center

    Pittenger, David J.

    1993-01-01

    The Myers Briggs Type Indicator (MBTI) is evaluated using a unified view of test validity that requires that validity be considered from an approach requiring many sources of corroboration. A review of available literature suggests insufficient evidence to support the tenets and claims about the utility of the MBTI. (SLD)

  1. Credible Immigration Policy Reform: A Response to Briggs

    ERIC Educational Resources Information Center

    Orrenius, Pia M.; Zavodny, Madeline

    2012-01-01

    The authors agree with Vernon M. Briggs, Jr., that U.S. immigration policy has had unexpected consequences. The 1965 immigration reforms led to unanticipated chain migration from developing countries whereas the 1986 Immigration Reform and Control Act failed to slow unauthorized immigration. The result is a large foreign-born population with…

  2. The Myers-Briggs type indicator--a management tool.

    PubMed

    Costello, K

    1993-05-01

    The Myers-Briggs Type Indicator can be an enlightening experience for managers as it uncovers blind spots as well as provides insight into managerial styles. This tool offers a way to build communication patterns that meet nurse managers' needs and the needs of the people they supervise.

  3. Item validity of the Myers-Briggs Type Indicator.

    PubMed

    Tzeng, O C; Outcalt, D; Boyer, S L; Ware, R; Landis, D

    1984-06-01

    The present study presents a brief summary of four extensive psychometric analyses of the Myers-Briggs Type Indicator (MBTI) items. Positive empirical evidence supports the MBTI item validity. However, several measurement issues on item construction were raised to caution the future users.

  4. Myers Briggs Type Indicator, burnout, and satisfaction in Illinois dentists.

    PubMed

    Baran, Ronald B

    2005-01-01

    There is conflicting research concerning satisfaction and burnout levels in dentistry. High levels of burnout can have deleterious effects on the dentist, his or her family, and patients. A random sample of Illinois general dentists was examined using the Myers Briggs Type Indicator, the Maslach Burnout Inventory, the Dentist Satisfaction Survey, and a demographic questionnaire. Areas examined were the frequency of types compared to a base population as well as the relationship of type to levels of satisfaction, burnout, and demographic items. Three of the 16 Myers Briggs types were overrepresented in this sample, while two types were underrepresented. Slightly less than half of the dentists were satisfied with their profession; 7.4% had reached significant levels of burnout and 83% perceived dentistry as being "very stressful." The personality types overrepresented in dentistry tended to have a higher level of satisfaction and a lower level of burnout compared to their cohort group.

  5. Rethinking communication apprehension: a Myers-Briggs perspective.

    PubMed

    Opt, S K; Loffredo, D A

    2000-09-01

    This study is an examination of relationships between Myers-Briggs personality type preferences, based on Jungian theory, and communication apprehension. Results showed that participants who preferred introversion or sensing reported significantly higher levels of communication apprehension in general and across the group, dyadic, meeting, and public contexts than did participants who preferred extraversion or intuition. In addition, participants who preferred feeling reported higher levels of communication anxiety in the public context than those who preferred thinking. Findings support the assumption that communication apprehension is biologically based, suggest that the Myers-Briggs type preference framework offers an alternative way of understanding communication apprehension, and point out the need for new approaches to understanding the phenomenon of communication apprehension.

  6. VLA HI Imaging of the LARS+eLARS Galaxies: Global HI Properties

    NASA Astrophysics Data System (ADS)

    Eisner, Brian Andrew; Reilly, Bridget; Cannon, John M.; Hayes, Matthew; Melinder, Jens; Östlin, Göran; Pardy, Stephen; LARS Team

    2017-01-01

    The Lyman Alpha Reference Sample (LARS) and its extension (eLARS) form the most comprehensive effort to date to study the details of Lyman Alpha radiative transfer in galaxies. Direct imaging of Lyman Alpha emission from the Hubble Space Telescope is supplemented by a wealth of multi-wavelength observations designed to probe the complex processes that contribute to the escape or destruction of Lyman Alpha photons as they resonantly scatter in the neutral ISM. The 42 LARS+eLARS galaxies span a range of physical properties, including mass and star formation rate. In this work, we present new VLA D-configuration HI imaging of 32 LARS+eLARS galaxies designed to localize the HI gas and to measure the total HI mass. HI column density images and velocity fields are compared to SDSS imaging. Most galaxies are unresolved at this angular resolution; a companion poster presents imaging of interacting galaxies that are well-resolved.

  7. Preliminary test results of LAr prototype detector

    NASA Astrophysics Data System (ADS)

    Li, Pei-Xian; Guan, Meng-Yun; Yang, Chang-Gen; Zhang, Peng; Liu, Jin-Chang; Zhang, Yong-Peng; Guo, Cong; Wang, Yi

    2016-11-01

    Liquid argon (LAr) is an attractive target for the direct detection of WIMPs. A LAr prototype detector was designed to study the technology and properties of LAr detectors. The prototype detector had an active volume containing 0.65 kg of liquid argon. A liquid nitrogen (LN) cooling system allowed the temperature fluctuation of the liquid argon to be controlled within less than 0.1 K during a one month run. In the 22Na calibration run, the LAr prototype obtained 1.59±0.02 p.e./keV light yield for 511 keV gamma rays using a domestic-made argon purification system. Supported by China Ministry of Science and Technology (2010CB833003), National Nature Science Foundation of China, Youth Science Found (11305188)

  8. Photo-induced chaos in the Briggs-Rauscher reaction

    NASA Astrophysics Data System (ADS)

    Okazaki, Noriaki; Hanazaki, Ichiro

    1998-07-01

    Discovery of the photo-induced chaos in the Briggs-Rauscher system is reported. The chaotic oscillations were observed between the large- and the small-amplitude simple oscillatory states existent in low and high light intensity regions, respectively. Period-doubling sequence from the large-amplitude oscillations to the chaos was observed. Deterministic nature of the chaos was confirmed by the next-amplitude return map. The stretching and folding mechanism of the trajectories was revealed through the three-dimensional attractor reconstructed via the singular value decomposition method. The chemical origin of the photoinduced chaos is discussed based on the photoautocatalysis of HIO2.

  9. The Myers-Briggs type indicator and coronary heart disease.

    PubMed

    Thorne, B M; Fyfe, J H; Carskadon, T G

    1987-01-01

    Researchers have for many years attempted to establish a relationship between coronary heart disease (CHD) and personality type. In our study, 103 subjects completed Form G of the Myers-Briggs Type Indicator (MBTI). Comparisons were made between 93 CHD patients and an age-appropriate control group (Group C) on each of the four MBTI dimensions: Extraversion-Introversion, Sensing-Intuition, Thinking-Feeling, and Judging-Perceiving. The comparison between CHD patients and Group C showed that CHD patients were significantly more likely to prefer sensing and feeling.

  10. Myers-Briggs personality types of art collectors.

    PubMed

    Gridley, Mark C

    2004-04-01

    27 art collectors (13 men, 14 women) completed the Myers-Briggs Type Indicator. Their age range was 37 to 86 years and the mean 59.5 yr. Seventy percent were classified as Intuition types instead of Sensation types (versus its 25% incidence in the general population). This corresponds to personality profiles of artists and the disproportionately high incidence of high scores on the related Openness to Experience factor in studies of creative personalities, thereby supporting the contention that persons creating art and appreciating art have personality traits in common.

  11. A Technical Review of the Myers-Briggs Type Indicator(tm).

    ERIC Educational Resources Information Center

    Denham, Thomas J.

    This paper describes the Myers-Briggs Type Indicator (MBTI), developed by I. Myers and K. Briggs (1940s) to assess personality type. Based on Jungian theory, the MBTI has become a tool for identifying the 16 different patterns of action into which every person fits. The 16 personality types are based on patterns of: (1) extraversion-introversion;…

  12. Myers-Briggs® Preferences and Academic Success in the First College Semester

    ERIC Educational Resources Information Center

    Sanborn, Debra K.

    2013-01-01

    This research examined aspects of Myers-Briggs® preferences and academic success in the first college semester. Academic aptitude as measured by precollege characteristics of ACT and class rank, academic performance during the first semester of college, and Myers-Briggs preference were analyzed for their significance within a learning community at…

  13. Myers-Briggs® Preferences and Academic Success in the First College Semester

    ERIC Educational Resources Information Center

    Sanborn, Debra K.

    2013-01-01

    This research examined aspects of Myers-Briggs® preferences and academic success in the first college semester. Academic aptitude as measured by precollege characteristics of ACT and class rank, academic performance during the first semester of college, and Myers-Briggs preference were analyzed for their significance within a learning community at…

  14. Liquor Activity Reduction (LAR) Programme - 12397

    SciTech Connect

    Pether, Colin; Carrol, Phil; Birkett, Eddie; Kibble, Matthew

    2012-07-01

    Waste material from the reprocessing of irradiated fuel has been stored under water for several decades leading to the water becoming highly radioactive. As a critical enabler to the decommissioning strategy for the Sellafield site, the Liquor Activity Reduction (LAR) programme has been established to provide a processing route for this highly radioactive liquor. This paper reviews the progress that has been made since the start of routine LAR transfer cycles (July 2010) and follows on from the earlier paper presented at WM2011. The paper focuses on the learning from the first full year of routine LAR transfer cycles and the application of this learning to the wider strategies for the treatment of further radioactive liquid effluents on the Sellafield site. During this period over 100,000 Curies of radioactivity has been safely removed and treated. The past year has witnessed the very successful introduction of the LAR programme. This has lead to hazard reduction at MSSS and demonstration that the SIXEP facility can meet the significantly increased challenge that the LAR programme represents. Part of the success has been the ability to predict and deliver a realistic production schedule with the availability of the MSSS, EDT and SIXEP facilities being central to this. Most importantly, the LAR programme has been successful in bringing together key stakeholders to deliver this work while integrating with the existing, day to day, demands of the Sellafield site. (authors)

  15. VLA HI Imaging of the LARS+eLARS Galaxies: Tidally Interacting Systems

    NASA Astrophysics Data System (ADS)

    Reilly, Bridget; Eisner, Brian Andrew; Cannon, John M.; Hayes, Matthew; Melinder, Jens; Östlin, Göran; Pardy, Stephen; LARS Team

    2017-01-01

    The Lyman Alpha Reference Sample (LARS) and its extension (eLARS) form the most comprehensive effort to date to study the details of Lyman Alpha radiative transfer in galaxies. Direct imaging of Lyman Alpha emission from the Hubble Space Telescope is supplemented by a wealth of multi-wavelength observations designed to probe the complex processes that contribute to the escape or destruction of Lyman Alpha photons as they resonantly scatter in the neutral ISM. The 42 LARS+eLARS galaxies span a range of physical properties, including mass and star formation rate. A companion poster presents VLA HI imaging of 32 LARS+eLARS galaxies. In this work, we present new VLA D-configuration HI imaging of selected LARS+eLARS galaxies that are well-resolved or tidally interacting. HI column density and velocity field images are compared to SDSS imaging. We interpret the results in the context of tidal interactions shifting the HI gas out of resonance and increasing the likelihood of Lyman Alpha photons escaping the galaxy.

  16. The LArIAT experiment at Fermilab

    SciTech Connect

    Nutini, Irene

    2016-03-01

    The LArIAT experiment at Fermilab is part of the International Neutrino program recently approved in the US. LArIAT aims to measure the main features of charged particles interactions in argon in the energy range (0.2 - 2.0 GeV) corresponding to the energy spectrum of the same particles when produced in a neutrino-argon interaction (neutrino energies of few GeV) typical of the short- and long-baseline neutrino beams of the Neutrino Program. Data collected from the 1st Run are being analyzed for both Physics studies and a technical characterization of the scintillation light collection system. Furthermore, two analysis topics are reported: the method developed for charged pion cross section measurement, based on the specific features of the LArTPC, and the development and test of the LArIAT custom-designed cold front-end electronics for SiPM devices to collect LAr scintillation light.

  17. The LArIAT experiment at Fermilab

    DOE PAGES

    Nutini, Irene

    2016-03-01

    The LArIAT experiment at Fermilab is part of the International Neutrino program recently approved in the US. LArIAT aims to measure the main features of charged particles interactions in argon in the energy range (0.2 - 2.0 GeV) corresponding to the energy spectrum of the same particles when produced in a neutrino-argon interaction (neutrino energies of few GeV) typical of the short- and long-baseline neutrino beams of the Neutrino Program. Data collected from the 1st Run are being analyzed for both Physics studies and a technical characterization of the scintillation light collection system. Furthermore, two analysis topics are reported: themore » method developed for charged pion cross section measurement, based on the specific features of the LArTPC, and the development and test of the LArIAT custom-designed cold front-end electronics for SiPM devices to collect LAr scintillation light.« less

  18. The Liquid Annular Reactor System (LARS) propulsion

    NASA Technical Reports Server (NTRS)

    Powell, James; Ludewig, Hans; Horn, Frederick; Lenard, Roger

    1990-01-01

    A concept for very high specific impulse (greater than 2000 seconds) direct nuclear propulsion is described. The concept, termed the liquid annular reactor system (LARS), uses liquid nuclear fuel elements to heat hydrogen propellant to very high temperatures (approximately 6000 K). Operating pressure is moderate (approximately 10 atm), with the result that the outlet hydrogen is virtually 100 percent dissociated to monatomic H. The molten fuel is contained in a solid container of its own material, which is rotated to stabilize the liquid layer by centripetal force. LARS reactor designs are described, together with neutronic and thermal-hydraulic analyses. Power levels are on the order of 200 megawatts. Typically, LARS designs use seven rotating fuel elements, are beryllium moderated, and have critical radii of approximately 100 cm (core L/D approximately equal to 1.5).

  19. Myers Briggs Type indicator personality profiles in unipolar depressed patients.

    PubMed

    Janowsky, David S; Hong, Elliot; Morter, Shirley; Howe, Laura

    2002-10-01

    The current study was designed to compare the distribution of Myers Briggs Type Indicator (MBTI) personality types in patients with Unipolar Depression compared to normative data. The MBTI divides individuals into four dichotomous types: Extroverted and Introverted, Sensing and Intuitive, Thinking and Feeling, and Judging and Perceiving. This yields eight single-factor and sixteen four-factor types. One-hundred-thirty Unipolar Depressed patients were administered the MBTI-Form F. Unipolar Depressed patients were significantly more often Introverted, Sensing, Feeling, and Perceiving single-factor types respectively, and Introverted-Sensing-Feeling-Perceiving, and Introverted-Intuitive-Feeling-Perceiving four-factor types. The male Introverted-Sensing-Feeling-Perceiving four-factor type was the most dramatically over-represented. The MBTI effectively discriminates a patient group with Unipolar Depression from a normative population.

  20. A comparative view of the Myers-Briggs type indicator.

    PubMed

    Eicke, F J; Blake, G; Replogle, W

    1993-03-01

    Many family practice residency programs use the Myers-Briggs Type Indicator (MBTI) in the process of resident advising. The purpose of this study was to validate the MBTI with an alternative personality evaluation instrument. We evaluated 44 residents with both the MBTI and the Sixteen Personality Factor Questionnaire (16PF) and computed correlation coefficients. The highest correlations between the two tests were for the Extraversion/Introversion dimension of personality (r = -.71). The 16PF factors of Tough Poise, Independence, and Superego/Control were also significantly correlated with items on the MBTI. The Anxiety dimension of the 16PF yielded no significant correlations with the MBTI. The Extraversion/Introversion variables of the MBTI and 16PF are highly correlated. Other variables on the 16PF and MBTI are also correlated.

  1. Recent assessments of the Myers-Briggs Type Indicator.

    PubMed

    Carlson, J G

    1985-08-01

    The present paper focuses on approximately two dozen recent published studies that examined reliability and validity of the Myers-Briggs Type Indicator (MBTI) in clinical, counseling, and research settings. Several assessments of split-half and test-retest reliability of the standard Form F and shorter Form G of the Inventory have yielded generally satisfactory correlations for all four scales. A larger number of studies of construct validity of the MBTI have yielded support for research hypotheses in situations ranging from correlations of the MBTI with a personality inventory, to couples problems in a counseling setting, to line judgment in groups, and others. Therefore, the applications of the MBTI have been broad, although somewhat unsystematic, and with generally favorable validity assessment. Continued attempts to validate the instrument in a variety of settings are needed.

  2. Self-Selection Patterns of College Roommates as Identified by the Myers-Briggs Type Indicator.

    ERIC Educational Resources Information Center

    Anchors, W. Scott; Hale, John, Jr.

    1985-01-01

    Investigated patterns and processes by which students (N=422) made unassisted roommate pairings within residence halls using the Myers-Briggs Type Indicator. Results indicated introverts, intuitives, feelers, and perceivers each tended to self-select. (BL)

  3. Seven Scales for the Minnesota-Briggs History Record With Reference Group Data

    ERIC Educational Resources Information Center

    Briggs, Peter F.; And Others

    1972-01-01

    The Minnesota-Briggs History Record (M-B) is a self-administered history inventory. This monograph summarizes studies of the M-B and describes the development of seven scales based upon M-B items. (Authors)

  4. Seven Scales for the Minnesota-Briggs History Record With Reference Group Data

    ERIC Educational Resources Information Center

    Briggs, Peter F.; And Others

    1972-01-01

    The Minnesota-Briggs History Record (M-B) is a self-administered history inventory. This monograph summarizes studies of the M-B and describes the development of seven scales based upon M-B items. (Authors)

  5. Using the Myers Briggs Type Indicator--part of the solution?

    PubMed

    Allen, J

    The Myers Briggs Type Indicator, which is based on the work of Jung, is used in an infinite variety of settings to enhance learning, personal development and team building. This article describes its particular relevance to the nursing profession.

  6. Myers-Briggs Type Indicator and dental school performance.

    PubMed

    Jones, A C; Courts, F J; Sandow, P L; Watson, R E

    1997-12-01

    The Myers-Briggs Type Indicator (MBTI) was administered to 256 dental students, representing four classes, at the University of Florida College of Dentistry. The results of this psychological instrument were then correlated with overall dental school performance based on results from the National Dental Board Examinations Part I and II (NB-I, NB-II), yearly class rank, and specific academic difficulties as measured by the Student Performance Evaluation Committee. Introverted students were found to display a significantly increased performance on NB-I (p = .038) and NB-II (p = .044). They were also found, however, to demonstrate a progressively lower class rank over the four-year period than extroverted students and were more likely to experience major academic difficulties as well. Judging and sensing individuals were found to earn a higher class rank over the four-year period than perceiving and intuitive students, respectively. Perceiving students were found to exhibit major difficulties or were placed on probation more often than judging individuals. These results may prove useful in counseling students to recognize potential problems before they commence their dental education or to anticipate and address specific weaknesses during the course of their education.

  7. Pollen Dispersal by Catapult: Experiments of Lyman J. Briggs on the Flower of Mountain Laurel

    NASA Astrophysics Data System (ADS)

    Nimmo, John R.; Hermann, Paula M.; Kirkham, M. B.; Landa, Edward R.

    2014-09-01

    The flower of Kalmia latifolia L. employs a catapult mechanism that flings its pollen to considerable distances. Physicist Lyman J. Briggs investigated this phenomenon in the 1950s after retiring as longtime director of the National Bureau of Standards, attempting to explain how hydromechanical effects inside the flower's stamen could make it possible. Briggs's unfinished manuscript implies that liquid under negative pressure generates stress, which, superimposed on the stress generated from the flower's growth habit, results in force adequate to propel the pollen as observed. With new data and biophysical understanding to supplement Briggs's experimental results and research notes, we show that his postulated negative-pressure mechanism did not play the exclusive and crucial role that he credited to it, though his revisited investigation sheds light on various related processes. Important issues concerning the development and reproductive function of Kalmia flowers remain unresolved, highlighting the need for further biophysical advances.

  8. Effects of Joint Interpretation of the Strong Interest Inventory and the Myers-Briggs Type Indicator in Career Choice.

    ERIC Educational Resources Information Center

    Katz, Louise; Joyner, John W.; Seaman, Nancy

    1999-01-01

    Students completed either the Strong Interest Inventory (n=114) or Myers-Briggs Type Indicator (n=108), both (n=99), or none (n=106). Twelve weeks after interpretation, those who completed both showed more change, specificity, or certainty in their career goal. The Myers-Briggs proved as helpful as Strong in career decision making. (SK)

  9. Effects of Joint Interpretation of the Strong Interest Inventory and the Myers-Briggs Type Indicator in Career Choice.

    ERIC Educational Resources Information Center

    Katz, Louise; Joyner, John W.; Seaman, Nancy

    1999-01-01

    Students completed either the Strong Interest Inventory (n=114) or Myers-Briggs Type Indicator (n=108), both (n=99), or none (n=106). Twelve weeks after interpretation, those who completed both showed more change, specificity, or certainty in their career goal. The Myers-Briggs proved as helpful as Strong in career decision making. (SK)

  10. Relationship between Myers-Briggs Type Indicator and Gregorc Style Delineator.

    PubMed

    Harasym, P H; Leong, E J; Juschka, B B; Lucier, G E; Lorscheider, F L

    1996-06-01

    The relationship between the Myers-briggs Type Indicator and Gregorc Style Delineator, and achievement was examined by administering these instruments to 259 first-year nursing students enrolled in an introductory human anatomy and physiology course. A principal component factor analysis using a varimax rotation of the scores from the two psychometric instruments, achievement examinations and an over-all grade point average indicated that each learning style from the Gregorc Style Delineator corresponds to certain traits on the Myers-Briggs Type Indicator. An individual who had a preference for the learning style of Concrete Sequential tended to have the traits of sensing and judging on the Myers-Briggs Type Indicator, while an individual who used the learning style of Concrete Random tended to have the traits of intuition and perceiving on the Myers-Briggs Type Indicator. One who had a preference for the learning style of Abstract Sequential tended to use the trait of thinking while another who used the learning style of Abstract Random tended to have the trait of feeling. The factor analysis also indicates no relationship of any scores of the traits on the Myers-Briggs Type Indicator or learning styles of the Gregorc Style Delineator with the examination scores achieved in the human anatomy and physiology course or to the students' over-all grade point average. However, factor analysis indicates that the Myers-Briggs Type Indicator traits of Judging vs Perceiving collapsed into the Sensing vs Intuition scale, and that the Gregorc Style Delineator consists of two bipolar scales that are different from those proposed by Gregorc.

  11. [Treatment of acromegaly with octreotide LAR].

    PubMed

    Sosa, Ernesto; Espinosa-de-los-Monteros, Ana Laura; González, Baldomero; Vargas, Guadalupe; Mier, Fernando; Mercado, Moisés

    2008-01-01

    Treatment of acromegaly with somastostatin analogues, albeit highly effective, is not curative and its elevated cost represents a major disadvantage. Hereby we describe our Center's experience using a fixed, 20 mg q.4 weeks- dose of octreotide LAR. 97 patients, 69 females, 71 with macroadenomas, treated with 20-mg im injections of octreotide LAR every 4 weeks, in 23 as primary therapy. No dose escalation was allowed. Patients were evaluated with GH and IGF-1 levels at 4 weeks after the third injection; thereafter, assessments occurred at 3 to 6 months intervals. In 27 unselected patients, evaluations were also performed 6 weeks after the SA injection. A GH concentration < 2.5 ng/mL was reached by 71%, 75% and 83% of patients at the 3rd , 6th and 12th months of follow up respectively, whereas over 30% achieved an IGF-1 index < or = 1.0 at each of these time points, and both biochemical goals were achieved by 30%, 33% and 32% of patients at the same time points. Biochemical success was the same for those patients treated primarily and those treated secondarily and prior radiation made no difference. A baseline GH level > 10 ng/mL was associated with a poor response. A biochemical control rate comparable with other published series it is feasible to reach with the treatment with a fixed dose of 20 mg.

  12. Liquid argon scintillation light studies in LArIAT

    SciTech Connect

    Kryczynski, Pawel

    2016-10-12

    The LArIAT experiment is using its Liquid Argon Time Projection Chamber (LArTPC) in the second run of data-taking at the Fermilab Test Beam Facility. The goal of the experiment is to study the response of LArTPCs to charged particles of energies relevant for planned neutrino experiments. In addition, it will help to develop and evaluate the performance of the simulation, analysis, and reconstruction software used in other LAr neutrino experiments. Particles from a tertiary beam detected by LArIAT (mainly protons, pions and muons) are identified using a set of beamline detectors, including Wire Chambers, Time of Flight counters and Cherenkov counters, as well as a simplified sampling detector used to detect muons. In its effort towards augmenting LArTPC technology for other neutrino experiments, LArIAT also takes advantage of the scintillating capabilities of LAr and is testing the possibility of using the light signal to help reconstruct calorimetric information and particle ID. In this report, we present results from these studies of the scintillation light signal to evaluate detector performance and calorimetry.

  13. Liquid argon scintillation light studies in LArIAT

    NASA Astrophysics Data System (ADS)

    Kryczynski, Pawel; LArIAT Collaboration

    2017-09-01

    The LArIAT experiment is using its Liquid Argon Time Projection Chamber (LArTPC) in the second run of data-taking at the Fermilab Test Beam Facility. The goal of the experiment is to study the response of LArTPCs to charged particles of energies relevant for planned neutrino experiments. In addition, it will help to develop and evaluate the performance of the simulation, analysis, and reconstruction software used in other LAr neutrino experiments. Particles from a tertiary beam detected by LArIAT (mainly protons, pions and muons) are identified using a set of beamline detectors, including Wire Chambers, Time of Flight counters and Cherenkov counters, as well as a simplified sampling detector used to detect muons. In its effort towards augmenting LArTPC technology for other neutrino experiments, LArIAT also takes advantage of the scintillating capabilities of LAr and is testing the possibility of using the light signal to help reconstruct calorimetric information and particle ID. In this report, we present results from these studies of the scintillation light signal to evaluate detector performance and calorimetry.

  14. Myers-Briggs Attitude Typology: The Influence of Birth Order with Other Family Variables.

    ERIC Educational Resources Information Center

    Stansbury, Virginia K.; Coll, Kenneth M.

    1998-01-01

    Investigates the influence of birth order with parenting style, age spacing, gender, and socioeconomic status on the Myers-Briggs attitude scales of Extroversion/Introversion and Judging/Perceiving. Results indicate that age spacing interacted with birth order to influence Extroversion/Introversion scores. Parenting style and gender interacted…

  15. Myers-Briggs Attitude Typology: The Influence of Birth Order with Other Family Variables.

    ERIC Educational Resources Information Center

    Stansbury, Virginia K.; Coll, Kenneth M.

    1998-01-01

    Investigates the influence of birth order with parenting style, age spacing, gender, and socioeconomic status on the Myers-Briggs attitude scales of Extroversion/Introversion and Judging/Perceiving. Results indicate that age spacing interacted with birth order to influence Extroversion/Introversion scores. Parenting style and gender interacted…

  16. Enhancing Student Team Effectiveness: Application of Myers-Briggs Personality Assessment in Business Courses

    ERIC Educational Resources Information Center

    Amato, Christie H.; Amato, Louis H.

    2005-01-01

    This article examines the relationship between student perceptions of team learning experience and communication style. Student group learning perceptions were evaluated and team communication style was measured using dyads derived from Myers-Briggs personality profiles. Groups containing similar personalities were classified as compatible,…

  17. Myers-Briggs Type Indicators and Kirton Adaption-Innovation Inventory Correlations.

    DTIC Science & Technology

    1994-04-01

    Astrologies ," Theology Today, page 292. 2. Ron Zemke, "Second Thoughts About the MBTI," Training, April 1993, page 43. 3. Otto Kroeger and Janet M. Theusen...March 1990): 30-32. Long, Thomas. "Myers-Briggs and Other Modern Astrologies ." Theology Today. 291-294. Reis, Dayr A. and John H. Button. "Bureaucracy and

  18. Age Group Differences and Estimated Frequencies of the Myers-Briggs Type Indicator Preferences.

    ERIC Educational Resources Information Center

    Cummings, William H., III

    1995-01-01

    Reports results of analyses of key tables in the Myers-Briggs Type Indicator Atlas of Type Tables. Significant age group effects on every dimension indicates the need to reestimate population norms for each continuum on the MBTI for interpreting scores of people of various ages. (LKS)

  19. A Description and Evaluation of the Myers-Briggs Type Indicator.

    ERIC Educational Resources Information Center

    Stricker, Lawrence J.; Ross, John

    The Myers-Briggs Type Indicator is a Jungian-oriented self-report inventory which classifies people into dichotomous categories along four scales: extraversion-introversion, sensation-intuition, thinking-feeling, and judgment-perception. Introduced in 1942, the scoring and items have changed after several items analyses. Form F contains 51 phrase…

  20. Prediction of Academic Success with the Myers-Briggs Type Indicator (MBTI). AIR Forum 1981 Paper.

    ERIC Educational Resources Information Center

    Hengstler, Dennis D.; And Others

    The relationship between personality characteristics and academic success of college freshmen at a predominantly female campus was studied, using the Myers-Briggs Type indicator (MBTI) to measure personality and first-year grade point average to measure academic success. The comparative effectiveness of the MBTI and the traditional predictors…

  1. Enhancing Student Team Effectiveness: Application of Myers-Briggs Personality Assessment in Business Courses

    ERIC Educational Resources Information Center

    Amato, Christie H.; Amato, Louis H.

    2005-01-01

    This article examines the relationship between student perceptions of team learning experience and communication style. Student group learning perceptions were evaluated and team communication style was measured using dyads derived from Myers-Briggs personality profiles. Groups containing similar personalities were classified as compatible,…

  2. Myers-Briggs Psychological Type and Achievement in Anatomy and Physiology.

    ERIC Educational Resources Information Center

    Harasym, P. H.; And Others

    1995-01-01

    Results from the Myers-Briggs Type Indicator (MBTI) for 259 nursing students were compared with achievement on examinations in an anatomy and physiology course. Factor analysis demonstrated no relationship between examination scores and any of the individual personality traits purported to be measured by MBTI. Analysis of variance revealed no…

  3. Teacher's Myers-Briggs Personality Profiles: Identifying Effective Teacher Personality Traits

    ERIC Educational Resources Information Center

    Rushton, Stephen; Morgan, Jackson; Richard, Michael

    2007-01-01

    The Myers-Briggs Type Inventory (MBTI) and Beiderman Risk Taking (BRT) scale were administered to 58 teachers living in the state of Florida, USA. These teachers are considered part of prestigious group of educators who were nominated into the Florida League of Teachers by their superintendents/directors. Descriptive data includes frequency and…

  4. The Myers-Briggs Type Indicator as a Measure of Aspects of Cognitive Style.

    ERIC Educational Resources Information Center

    Carey, John C.; And Others

    1989-01-01

    Examined relationships between Myers-Briggs Type Indicator (MBTI) scales and established measures of field dependence-independence and cognitive complexity using female college students (N=79). Found subscales correlated significantly with measures of field dependence-independence but not with measure of cognitive complexity. Found MBTI measured…

  5. The Myers-Briggs Type Indicator: A Measure for Individuals and Groups.

    ERIC Educational Resources Information Center

    McCaulley, Mary H.

    1990-01-01

    Describes Myers-Briggs Type Indicator (MBTI). Looks at history and development of the MBTI, characteristics, scores, Jung's theory of lifelong development, the dynamic interaction of the four functions measured by the MBTI, the construction of the MBTI, use with groups, how to use type tables, and use of the MBTI in career counseling. (NB)

  6. Essentials of Myers-Briggs Type Indicator[R] Assessment. Essentials of Psychological Assessment Series.

    ERIC Educational Resources Information Center

    Quenk, Naomi L.

    This book provides step-by-step guidance on the administration, scoring, and interpretation of the Myers-Briggs Type Indicator[R] (MBTI). The book also contains assessment of the test's strengths and weaknesses, advice on its clinical applications, and several case reports. The chapters are: (1) "Overview"; (2) "How To Administer…

  7. Using the Myers-Briggs Type Indicator in the Social Work Classroom.

    ERIC Educational Resources Information Center

    Aviles, Christopher B.

    The Myers-Briggs Type Indicator (MBTI) is one of the most popular measures of personality available today and has been taken by over 12 million people. The MBTI has been successfully utilized for personal and marriage counseling, conflict and stress management, and understanding learning styles. It is perfect for the social work classroom because…

  8. A Higher Order Analysis of the Factor Structure of the Myers-Briggs Type Indicator.

    ERIC Educational Resources Information Center

    Johnson, William L.; Mauzey, Edward; Johnson, Annabel M.; Murphy, Stanley D.; Zimmerman, Kurt J.

    2001-01-01

    Examines the higher order structure of Form G of the Myers Briggs Type Indicator. A third order component analysis of a sample (N=926) found two higher order components. This higher order analysis contributes to the research literature pertaining to the generalized structure of the personality measure. (Contains 44 references and 1 table.) (GCP)

  9. Properties of a photonic crystal formed in a solution featuring the Briggs-Rauscher oscillating reaction

    NASA Astrophysics Data System (ADS)

    Usanov, D. A.; Rytik, A. P.

    2016-06-01

    It is shown that a solution featuring the Briggs-Rauscher (BR) oscillating chemical reaction can exhibit the properties of a photonic crystal with alternating bandgap width. Thicknesses and dielectric permittivities of structural elements in the BR reaction solution have been determined by measuring the reflection and transmission spectra of microwave radiation in the range of 5-8 GHz.

  10. Utilizing the Myers-Briggs Personality Inventory in Employee Assistance Program Workplace Seminars.

    ERIC Educational Resources Information Center

    Aviles, Christopher B.

    Social work educators are being called upon more often to deliver employee workplace seminars for community agencies on a variety of topics ranging from burnout and stress management to improving workplace communication and managing workplace conflicts. One tool that addresses workplace communication is the Myers-Briggs Type Indicator (MBTI). It…

  11. The Myers-Briggs Type Indicator and the Teaching-Learning Process.

    ERIC Educational Resources Information Center

    McCaulley, Mary H.

    The Myers-Briggs Type Indicator (MBTI) was developed specifically to make possible the implementation of Carl Jung's theory of type and is concerned mainly with conscious elements of the personality. It assumes that to function well, an individual must have a well-developed system for perception and a well-developed system for making decisions or…

  12. Survey of Librarians Using the Myers-Briggs Type Indicator (Form G Self-Scorable).

    ERIC Educational Resources Information Center

    Johns, Alan

    A survey conducted in February 1990 asked 100 librarians to respond to a mailed Myers-Briggs Type Indicator (MBTI), a widely used personality survey that determines Jungian personality types. The results of the MBTI can be applied to building work teams in the library. Forty-eight librarians responded to the survey. Their responses were tallied…

  13. Teacher's Myers-Briggs Personality Profiles: Identifying Effective Teacher Personality Traits

    ERIC Educational Resources Information Center

    Rushton, Stephen; Morgan, Jackson; Richard, Michael

    2007-01-01

    The Myers-Briggs Type Inventory (MBTI) and Beiderman Risk Taking (BRT) scale were administered to 58 teachers living in the state of Florida, USA. These teachers are considered part of prestigious group of educators who were nominated into the Florida League of Teachers by their superintendents/directors. Descriptive data includes frequency and…

  14. Differences in Myers-Briggs Personality Types among High School Band, Orchestra, and Choir Members

    ERIC Educational Resources Information Center

    MacLellan, Christin Reardon

    2011-01-01

    The purpose of this study was to explore personality type differences among high school band, string orchestra, and choir students according to ensemble membership. Participants (N = 355) were high school students who had participated in their school's band, orchestra, or choir for 1 year or more. The author administered the Myers-Briggs Type…

  15. Opposition from Christians to Myers-Briggs Personality Typing: An Analysis and Evaluation

    ERIC Educational Resources Information Center

    Lloyd, John B.

    2007-01-01

    Myers-Briggs personality typing is widely used in the Christian church as an aid to individual self-understanding and spiritual formation. However, some Christian leaders have expressed doubt about its validity in understanding human personality and also opposition to its use in nurturing spiritual growth. The aim of the work reported was to…

  16. Personality Characteristics of South Korean Students with Visual Impairments Using the Myers-Briggs Type Indicator

    ERIC Educational Resources Information Center

    Bak, Sunhi

    2012-01-01

    Introduction: The study presented here was designed to determine whether there were significant differences in the frequency and preference scores of personality functions and the frequency of personality types, as measured by the Myers-Briggs Type Indicator (MBTI), by gender, school level, and level of visual function, of students with visual…

  17. Two Approaches to Examining the Stability of Myers-Briggs Type Indicator Scores

    ERIC Educational Resources Information Center

    Salter, Daniel W.; Forney, Deanna S.; Evans, Nancy J.

    2005-01-01

    In this study, two approaches are used to assess the stability of Myers-Briggs Type Indicator scores across 3 administrations (N = 231): longitudinal configural frequency analysis with categorical scores and generalizability theory with the Preference Clarity Indices and continuous scores. The results are generally positive. Evaluation of…

  18. Myers-Briggs Type Indicator Score Reliability across Studies: A Meta-Analytic Reliability.

    ERIC Educational Resources Information Center

    Capraro, Robert M.; Capraro, Mary Margaret

    2002-01-01

    Submitted the Myers-Briggs Type Indicator (MBTI) to a descriptive reliability generalization analysis to characterize the variability of measurement error in MBTI scores across administrations. In general the MBTI and its scales yielded scores with strong internal consistency and test-retest reliability estimates. (SLD)

  19. A Higher Order Analysis of the Factor Structure of the Myers-Briggs Type Indicator.

    ERIC Educational Resources Information Center

    Johnson, William L.; Mauzey, Edward; Johnson, Annabel M.; Murphy, Stanley D.; Zimmerman, Kurt J.

    2001-01-01

    Examines the higher order structure of Form G of the Myers Briggs Type Indicator. A third order component analysis of a sample (N=926) found two higher order components. This higher order analysis contributes to the research literature pertaining to the generalized structure of the personality measure. (Contains 44 references and 1 table.) (GCP)

  20. Interpreting the Myers-Briggs Type Indicator to Help Clients in Understanding Their Strong Interest Inventory.

    ERIC Educational Resources Information Center

    Healy, Charles C.

    2000-01-01

    Scores of 370 adults on the Myers Briggs Type Indicator (MBTI) were correlated with General Occupational Theme (GOT) scores on the Strong Interest Inventory. Simple categorical MBTI scores were related modestly to Strong GOT scores as expected; individual continuous scores did not account for more variance in GOT than in categorical scores. (SK)

  1. Use of the Myers-Briggs Type Indicator (MBTI) with Physicians: A Review of the Literature.

    ERIC Educational Resources Information Center

    Howard, David H.

    This document reviews the research on the use of the Myers-Briggs Type Indicator (MBTI), with medical students and physicians. The MBTI is a paper-and-pencil instrument based on C. G. Jung's theory of personality typology. The introductory section of the review describes the MBTI and explains its dimensions (extroverted versus introverted, sensing…

  2. Affirmative: In Support of Researching the Myers-Briggs Type Indicator.

    ERIC Educational Resources Information Center

    Carlson, John G.

    1989-01-01

    Updates 1985 review of Myers-Briggs Type Indicator (MBTI) noting recent criterion-based assessments of the MBTI remain largely unsystematic theoretically but generally positive. Claims more methodologically sophisticated approaches have been developed. Concludes that it seems premature to reject the MBTI owing either to its dichotomous approach to…

  3. General Psychology Assessment and Course Satisfaction Compared with the Myers-Briggs Type Indicator.

    ERIC Educational Resources Information Center

    Whitney, Gloria D.

    A study involving 211 students enrolled in eight sections of a general psychology course at Brevard Community College was conducted to determine if the course activities and testing methods were biased toward certain personality types, as defined by the Myers-Briggs Type Inventory (MBTI); and to evaluate the usefulness of the MBTI as a learning…

  4. Eysenck Personality Questionnaire and Jungian Myers-Briggs Type Indicator Correlation of Extraversion-Introversion

    ERIC Educational Resources Information Center

    Steele, Robert S.; Kelly, Thomas J.

    1976-01-01

    C. G. Jung and H. J. Eysenck developed concepts of extraversion-introversion from radically different theoretical orientations. It is hypothesized that given the methods and content similarity of the Eysenck Personality Questionnaire and the Myers-Briggs Type Indicator. Extraversion-Introversion scales of the inventories will be significantly…

  5. Effects of additives on the oscillations of the Briggs-Rauscher reaction

    NASA Astrophysics Data System (ADS)

    Cervellati, R.; Furrow, S. D.

    2013-12-01

    Perturbations with chemical species that have dissimilar physico-chemical properties, such as bromide ions, polyphenols or iron complexes, are often used to investigate the detailed molecular mechanism of the Briggs-Rauscher (BR) oscillating reaction. We describe in this review the effects caused by some of these species and present their mechanistic interpretations. Some new original results are also reported.

  6. Eysenck Personality Questionnaire and Jungian Myers-Briggs Type Indicator Correlation of Extraversion-Introversion

    ERIC Educational Resources Information Center

    Steele, Robert S.; Kelly, Thomas J.

    1976-01-01

    C. G. Jung and H. J. Eysenck developed concepts of extraversion-introversion from radically different theoretical orientations. It is hypothesized that given the methods and content similarity of the Eysenck Personality Questionnaire and the Myers-Briggs Type Indicator. Extraversion-Introversion scales of the inventories will be significantly…

  7. Relationship Between Personality Types on the Strong-Campbell and Myers-Briggs Instruments.

    ERIC Educational Resources Information Center

    Dillon, Michael; Weissman, Shel

    1987-01-01

    Examined relationship between Holland's personality types as measured by the Strong-Campbell Interest Inventory and Jung's personality types as measured by the Myers-Briggs Type Indicator. College students' (N=394) responses to the two instruments revealed significant associations between certain types based on interests and preferences.…

  8. Myers-Briggs Type Indicator Score Reliability across Studies: A Meta-Analytic Reliability.

    ERIC Educational Resources Information Center

    Capraro, Robert M.; Capraro, Mary Margaret

    2002-01-01

    Submitted the Myers-Briggs Type Indicator (MBTI) to a descriptive reliability generalization analysis to characterize the variability of measurement error in MBTI scores across administrations. In general the MBTI and its scales yielded scores with strong internal consistency and test-retest reliability estimates. (SLD)

  9. Opposition from Christians to Myers-Briggs Personality Typing: An Analysis and Evaluation

    ERIC Educational Resources Information Center

    Lloyd, John B.

    2007-01-01

    Myers-Briggs personality typing is widely used in the Christian church as an aid to individual self-understanding and spiritual formation. However, some Christian leaders have expressed doubt about its validity in understanding human personality and also opposition to its use in nurturing spiritual growth. The aim of the work reported was to…

  10. Predicting dentists' career choices using the Myers-Briggs type indicator.

    PubMed

    Grandy, T G; Westerman, G H; Ocanto, R A; Erskine, C G

    1996-02-01

    The Myers-Briggs Type Indicator is a psychological measure designed to determine personality preferences, learning styles and management styles and to assist with career choices. The authors surveyed 1,117 practicing dentists to determine if the MBTI was useful in determining which respondents were most likely to be specialists. They found no significant differences between general practitioners and specialists.

  11. Two Approaches to Examining the Stability of Myers-Briggs Type Indicator Scores

    ERIC Educational Resources Information Center

    Salter, Daniel W.; Forney, Deanna S.; Evans, Nancy J.

    2005-01-01

    In this study, two approaches are used to assess the stability of Myers-Briggs Type Indicator scores across 3 administrations (N = 231): longitudinal configural frequency analysis with categorical scores and generalizability theory with the Preference Clarity Indices and continuous scores. The results are generally positive. Evaluation of…

  12. Examination of the relationship between the Myers-Briggs Type Indicator and empathetic response.

    PubMed

    Jenkins, S J; Stephens, J C; Chew, A L; Downs, E

    1992-06-01

    This study investigated the potential relationship between the Myers-Briggs Type Indicator and level of empathetic responding. Analyses indicated that the Thinking-Feeling scale was significantly associated with ratings of empathy for 49 graduate students in counselor education. Sex and graduate grade point average were also related significantly to empathic responding. Results are discussed in terms of their significance for research.

  13. Differences in Myers-Briggs Personality Types among High School Band, Orchestra, and Choir Members

    ERIC Educational Resources Information Center

    MacLellan, Christin Reardon

    2011-01-01

    The purpose of this study was to explore personality type differences among high school band, string orchestra, and choir students according to ensemble membership. Participants (N = 355) were high school students who had participated in their school's band, orchestra, or choir for 1 year or more. The author administered the Myers-Briggs Type…

  14. Correlations between the Myers-Briggs Type Indicator and the Neo Personality Inventory facets.

    PubMed

    MacDonald, D A; Anderson, P E; Tsagarakis, C I; Holland, C J

    1995-04-01

    Using data obtained from 48 male and 161 female undergraduate students in psychology, correlations between scores on the scales of the Myers-Briggs Type Indicator and the facets of the Neuroticism, Extraversion, and Openness domains of the NEO Personality Inventory were low to moderate.

  15. Personality Characteristics of South Korean Students with Visual Impairments Using the Myers-Briggs Type Indicator

    ERIC Educational Resources Information Center

    Bak, Sunhi

    2012-01-01

    Introduction: The study presented here was designed to determine whether there were significant differences in the frequency and preference scores of personality functions and the frequency of personality types, as measured by the Myers-Briggs Type Indicator (MBTI), by gender, school level, and level of visual function, of students with visual…

  16. Postcrystallization metasomatism in shergottites: Evidence from the paired meteorites LAR 06319 and LAR 12011

    NASA Astrophysics Data System (ADS)

    Howarth, Geoffrey H.; Liu, Yang; Chen, Yang; Pernet-Fisher, John F.; Taylor, Lawrence A.

    2016-11-01

    Apatite is the major volatile-bearing phase in Martian meteorites, containing structurally bound fluorine, chlorine, and hydroxyl ions. In apatite, F is more compatible than Cl, which in turn is more compatible than OH. During degassing, Cl strongly partitions into the exsolved phase, whereas F remains in the melt. For these reasons, the volatile concentrations within apatite are predictable during magmatic differentiation and degassing. Here, we present compositional data for apatite and merrillite in the paired enriched, olivine-phyric shergottites LAR 12011 and LAR 06319. In addition, we calculate the relative volatile fugacities of the parental melts at the time of apatite formation. The apatites are dominantly OH-rich (calculated by stoichiometry) with variable yet high Cl contents. Although several other studies have found evidence for degassing in the late-stage mineral assemblage of LAR 06319, the apatite evolutionary trends cannot be reconciled with this interpretation. The variable Cl contents and high OH contents measured in apatites are not consistent with fractionation either. Volatile fugacity calculations indicate that water and fluorine activities remain relatively constant, whereas there is a large variation in the chlorine activity. The Martian crust is Cl-rich indicating that changes in Cl contents in the apatites may be related to an external crustal source. We suggest that the high and variable Cl contents and high OH contents of the apatite are the results of postcrystallization interaction with Cl-rich, and possibly water-rich, crustal fluids circulating in the Martian crust.

  17. Application of the Myers-Briggs Type Indicator to Medicine and Other Health Professions. Monograph I. Final Report.

    ERIC Educational Resources Information Center

    McCaulley, Mary H.

    This monograph is an overview and state of the art paper for the use of the Myers-Briggs Type Indicator in the health professions. The Myers-Briggs Type Indicator is a questionnaire which makes it possible to test and put to practical use that part of the personality theory of C.G. Jung which is concerned with psychological type. Nine areas of…

  18. Use of the Myers-Briggs Type Indicator to develop a continuing education department.

    PubMed

    Schoessler, M; Conedera, F; Bell, L F; Marshall, D; Gilson, M

    1993-01-01

    Myers-Briggs concepts are useful for understanding and managing individual and group strengths, preferences, and "blind spots." Requirements of the work to be accomplished can be matched to the strengths and preferences of the individual or group. Work groups can be selected to enhance individual strengths and to counterbalance blind spots. This article describes the experience of one hospital-based continuing education department that uses the Myers-Briggs Personality Trait Inventory to explore department members' strengths and preferences. Understanding individual preferences has helped group members to understand, anticipate, and work with one another. The ideal mix of profiles challenges and stimulates both the individual and the department. Maximizing diversity increases the potential for conflict between individuals with opposite preferences; recognizing strengths and blind spots, willingness to talk about work style differences, and a little humor all make peaceful coexistence possible.

  19. Over-representation of Myers Briggs Type Indicator introversion in social phobia patients.

    PubMed

    Janowsky, D S; Morter, S; Tancer, M

    2000-01-01

    The purpose of this study is to profile the personalities of patients with social phobia. Sixteen patients with social phobia were compared with a normative population of 55,971, and with 24 hospitalized Major Depressive Disorder inpatients, using the Myers Briggs Type Indicator. The Myers Briggs Type Indicator, a popular personality survey, divides individuals into eight categories: Extroverts versus Introverts, Sensors versus Intuitives, Thinkers versus Feelers, and Judgers versus Perceivers. Social phobia patients were significantly more often Introverts (93.7%) than were subjects in the normative population (46.2%). In addition, using continuous scores, the social phobia patients scored as significantly more introverted than did the patients with Major Depressive Disorder, who also scored as Introverted. Introversion is a major component of social phobia, and this observation may have both etiological and therapeutic significance.

  20. Relationship of Myers Briggs type indicator personality characteristics to suicidality in affective disorder patients.

    PubMed

    Janowsky, David S; Morter, Shirley; Hong, Liyi

    2002-01-01

    The current study characterized the Myers Briggs Type Indicator (MBTI) personality profiles of 64 suicidal and 30 non-suicidal psychiatric inpatients with affective disorder diagnoses. The MBTI divides individuals categorically into eight personality preferences (Extroverted and Introverted, Sensing and Intuitive, Thinking and Feeling, and Judging and Perceiving). Compared to the group of non-suicidal affective disorder patients, suicidal affective disorder patients were significantly more Introverted and Perceiving using ANCOVA analyses, and significantly more Introverted alone using Chi Square analyses.

  1. Reexamination of relations between the Myers-Briggs type indicator and field dependence-independence.

    PubMed

    Schmidt, C P; McCutcheon, J W

    1988-12-01

    The Group Embedded Figures Test and the Myers-Briggs Type Indicator were administered to 210 undergraduate and graduate students. Bivariate relations between the embedded figures test and the Indicator scales of Extraversion-Introversion (EI), Thinking-Feeling (TF), and Judgment-Perception (JP) were nonsignificant while the relation between scores on embedded figures and Sensing-Intuition (SN) was statistically significant. ESFP, ISFJ, and ESFJ types were significantly more field-dependent than the INFP and ENTP types.

  2. Inter- and intraspecific variation in the diets of sympatric siamang (Hylobates syndactylus) and lar gibbons (Hylobates lar).

    PubMed

    Palombit, R A

    1997-01-01

    Studies of the siamang (Hylobates syndactylus continentis) and the lar gibbon (Hylobates lar lar) where they co-occur in mainland Asia have demonstrated interspecific dietary segregation based on body size and have suggested that observed levels of frugivory represent metabolically based maxima for these species. I studied sympatric groups of siamang (H. s. syndactylus) and lar gibbons (H. l. vestitus) at Ketambe in northern Sumatra (Indonesia) in order to assess the magnitude of within- and between-species variation in diets. The insular subspecies are considerably more frugivorous (60-70% of feeding time) than mainland conspecifics (35-50%). This is primarily because Sumatran hylobatids spend about twice as much time (approx. 45% of feeding) eating fig fruits (Ficus spp., Moraceae). A higher density of figs at Ketambe (compared to Kuala Lompat) may account for this behavioral difference. Enhanced frugivory has been achieved at the expense of folivory, which is much reduced in Sumatra--especially in H. lar (4% of diet)- and is limited almost entirely to immature foliage. The expected decline in protein intake resulting from diminished folivory in Sumatra may be counterbalanced by observed increases in insectivory, which is especially pronounced in lar gibbons. Interspecific dietary segregation emerges most clearly in how individuals of each species supplement their similarly fig-dominated diets. Siamang rely more on immature foliage--primarily from lianas, which generate young leaves more reliably and abundantly than trees do. Conversely, lar gibbons exploit the pulpy fruit of trees and lianas more heavily than siamang do. This general pattern occurs where the two species coexist in Malaysia, thereby suggesting a substantive interspecific difference that is somewhat greater in the insular populations.

  3. Scintillation Light Detection System in LArIAT

    SciTech Connect

    Kryczynski, Pawel

    2016-02-29

    The LArIAT experiment is currently taking data at Fermilab using a Liquid Argon TPC, with the aim of studying particle interactions and characterizing detector response for neutrino detectors using argon. In parallel, it serves as a test-bench to develop and evaluate the performance of the simulation, reconstruction, and analysis software used in LAr neutrino experiments. LArIAT also takes advantage of the scintillating capabilities of liquid argon and will evaluate the feasibility of using the light signal to determine calorimetric information and particle identification. To test this possibility, a scintillation light detection system consisting of high Quantum Efficiency (QE) PMT and Silicon Photomultiplier (SiPM) devices is installed in the cryostat, viewing the interior of the TPC. Light collection efficiency is maximized by means of lining the walls with reflector foils covered by a wavelength shifter layer. Collecting the light reflected at the boundaries of the active volume greatly improves also the uniformity of the light yield. Presented here are initial results of the LArIAT light detection system calibration together with the preliminary results of the dedicated simulation and its application in future LAr TPC experiments

  4. Lasso Peptide Biosynthetic Protein LarB1 Binds Both Leader and Core Peptide Regions of the Precursor Protein LarA

    PubMed Central

    2016-01-01

    Lasso peptides are a member of the superclass of ribosomally synthesized and posttranslationally modified peptides (RiPPs). Like all RiPPs, lasso peptides are derived from a gene-encoded precursor protein. The biosynthesis of lasso peptides requires two enzymatic activities: proteolytic cleavage between the leader peptide and the core peptide in the precursor protein, accomplished by the B enzymes, and ATP-dependent isopeptide bond formation, accomplished by the C enzymes. In a subset of lasso peptide biosynthetic gene clusters from Gram-positive organisms, the B enzyme is split between two proteins. One such gene cluster is found in the organism Rhodococcus jostii, which produces the antimicrobial lasso peptide lariatin. The B enzyme in R. jostii is split between two open reading frames, larB1 and larB2, both of which are required for lariatin biosynthesis. While the cysteine catalytic triad is found within the LarB2 protein, LarB1 is a PqqD homologue expected to bind to the lariatin precursor LarA based on its structural homology to other RiPP leader peptide binding domains. We show that LarB1 binds to the leader peptide of the lariatin precursor protein LarA with a sub-micromolar affinity. We used photocrosslinking with the noncanonical amino acid p-azidophenylalanine and mass spectrometry to map the interaction of LarA and LarB1. This analysis shows that the LarA leader peptide interacts with a conserved motif within LarB1 and, unexpectedly, the core peptide of LarA also binds to LarB1 in several positions. A Rosetta model built from distance restraints from the photocrosslinking experiments shows that the scissile bond between the leader peptide and core peptide in LarA is in a solvent-exposed loop. PMID:27800552

  5. Lasso Peptide Biosynthetic Protein LarB1 Binds Both Leader and Core Peptide Regions of the Precursor Protein LarA.

    PubMed

    Cheung, Wai Ling; Chen, Maria Y; Maksimov, Mikhail O; Link, A James

    2016-10-26

    Lasso peptides are a member of the superclass of ribosomally synthesized and posttranslationally modified peptides (RiPPs). Like all RiPPs, lasso peptides are derived from a gene-encoded precursor protein. The biosynthesis of lasso peptides requires two enzymatic activities: proteolytic cleavage between the leader peptide and the core peptide in the precursor protein, accomplished by the B enzymes, and ATP-dependent isopeptide bond formation, accomplished by the C enzymes. In a subset of lasso peptide biosynthetic gene clusters from Gram-positive organisms, the B enzyme is split between two proteins. One such gene cluster is found in the organism Rhodococcus jostii, which produces the antimicrobial lasso peptide lariatin. The B enzyme in R. jostii is split between two open reading frames, larB1 and larB2, both of which are required for lariatin biosynthesis. While the cysteine catalytic triad is found within the LarB2 protein, LarB1 is a PqqD homologue expected to bind to the lariatin precursor LarA based on its structural homology to other RiPP leader peptide binding domains. We show that LarB1 binds to the leader peptide of the lariatin precursor protein LarA with a sub-micromolar affinity. We used photocrosslinking with the noncanonical amino acid p-azidophenylalanine and mass spectrometry to map the interaction of LarA and LarB1. This analysis shows that the LarA leader peptide interacts with a conserved motif within LarB1 and, unexpectedly, the core peptide of LarA also binds to LarB1 in several positions. A Rosetta model built from distance restraints from the photocrosslinking experiments shows that the scissile bond between the leader peptide and core peptide in LarA is in a solvent-exposed loop.

  6. Personality characteristics of hospice volunteers as measured by Myers-Briggs Type Indicator.

    PubMed

    Mitchell, C W; Shuff, I M

    1995-12-01

    A sample of hospice volunteers (n = 99) was administered the Myers-Briggs Type Indicator (Myers & McCaulley, 1985). Frequencies of types observed were compared to population sample (n = 1,105) frequencies. Results indicated that, as a whole, hospice volunteers preferred extraversion over introversion, intuition over sensing, and feeling over thinking. Analysis of four-and two-letter preference combinations also yielded statistically significant differences. Most notably, the sensing-intuitive function appeared pivotal in determining of hospice volunteering. Suggestions are offered as to why the sensing-intuition function appeared central to hospice volunteering. Results appeared consistent with Jungian personality theory.

  7. Communicator image and Myers-Briggs Type Indicator extraversion-introversion.

    PubMed

    Opt, Susan K; Loffredo, Donald A

    2003-11-01

    This study is an examination of the relationship between communicator image and Myers-Briggs Type Indicator (MBTI) dimensions of extraversion-introversion. The authors found that individuals who prefer extraversion tend to have a more positive communicator image than those who prefer introversion. The results of this study support other research results showing that personality preferences differ in communication behaviors and traits, which could have implications for the individual's comfort and success in society. Results of this research also support the contention that communication behavior has biological aspects.

  8. Some Fruits of Genius: Lars Onsager and the Ising Model

    NASA Astrophysics Data System (ADS)

    Fisher, Michael E.

    2006-03-01

    The story of the exact solution of the two-dimensional Ising model by Lars Onsager in the 1940's will be sketched and some of the striking developments following from it, especially for the behavior of fluctuating interfaces, will be recounted.

  9. Operation plan for the data 100/LARS terminal system

    NASA Technical Reports Server (NTRS)

    Bowen, A. J., Jr.

    1980-01-01

    The Data 100/LARS terminal system provides an interface for processing on the IBM 3031 computer system at Purdue University's Laboratory for Applications of Remote Sensing. The environment in which the system is operated and supported is discussed. The general support responsibilities, procedural mechanisms, and training established for the benefit of the system users are defined.

  10. ConvexLAR: An Extension of Least Angle Regression*

    PubMed Central

    Xiao, Wei; Zhou, Hua

    2016-01-01

    The least angle regression (LAR) was proposed by Efron, Hastie, Johnstone and Tibshirani (2004) for continuous model selection in linear regression. It is motivated by a geometric argument and tracks a path along which the predictors enter successively and the active predictors always maintain the same absolute correlation (angle) with the residual vector. Although it gains popularity quickly, its extensions seem rare compared to the penalty methods. In this expository article, we show that the powerful geometric idea of LAR can be generalized in a fruitful way. We propose a ConvexLAR algorithm that works for any convex loss function and naturally extends to group selection and data adaptive variable selection. After simple modification it also yields new exact path algorithms for certain penalty methods such as a convex loss function with lasso or group lasso penalty. Variable selection in recurrent event and panel count data analysis, Ada-Boost, and Gaussian graphical model is reconsidered from the ConvexLAR angle. PMID:27114697

  11. LAR, liprin alpha and the regulation of active zone morphogenesis.

    PubMed

    Stryker, Emily; Johnson, Karl G

    2007-11-01

    Active zones are protein-rich regions of neurons that act as sites of synaptic vesicle fusion and neurotransmitter release at the pre-synaptic terminus. Although the discovery that the receptor protein tyrosine phosphatase LAR and its cytoplasmic binding partner liprin alpha are essential for proper active zone formation is nearly a decade old, the underlying mechanisms are still poorly understood. Recent studies have identified a number of binding partners for both LAR and liprin alpha, several of which play key roles in active zone assembly. These include nidogen, dallylike and syndecan--extracellular ligands for LAR that regulate synapse morphogenesis. In addition, liprin-alpha-interacting proteins such as ERC2, RIM and the MALS/Veli-Cask-Mint1 complex cooperate to form a dense molecular scaffold at the active zone that is crucial for proper synaptic function. These studies allow us to propose testable models of LAR and liprin alpha function, and provide insights into the fundamental molecular mechanisms of synapse formation and stabilization.

  12. Obituary: Gary Lars Grasdalen, 1945-2003

    NASA Astrophysics Data System (ADS)

    Strom, Stephen Eric

    2003-12-01

    With the passing of Gary Grasdalen on 20 April 2003 the astronomical community has lost one its most creative members. Born in Albert Lea, Minnesota on 7 October 1945 to the farming family of Lars G. and Lillie Grasdalen, Gary developed a strong childhood interest in science, and a particular fascination with astronomy. In 1964, he entered Harvard College intending to pursue those interests. During his freshman year, Gary enrolled in an undergraduate research seminar in which he first displayed the combination of keen insight and imagination in applying new techniques that was manifest throughout his professional career. In 1968, he published his first two papers---studies of the C12/C13 ratio in metal deficient stars, and of Fe I and Fe II transition probabilities---which summarized research carried out during his junior and senior years at Harvard. Grasdalen next entered the astronomy graduate program at the University of California, Berkeley. There he developed a strong interest in the early stages of stellar evolution and, in particular, the potential of S-1 image intensifiers and newly available near-infrared detectors to detect and analyze the stellar populations embedded within their parent molecular cloud complexes. Following award of his PhD in 1972, Grasdalen was appointed to the staff at the Kitt Peak National Observatory. Early in his career at KPNO, Gary developed tools that enabled routine near-infrared mapping of nearby molecular cloud complexes, most notably the telescope control programs that enabled precise raster scanning of these regions. Those same programs were some of the many innovations in which Gary had a hand. These innovations enabled a generation of KPNO observers in the 1970s to fully exploit the power of the newly commissioned Mayall telescope as well as the smaller telescopes on Kitt Peak. In 1973, he published the first map of the central region of a molecular cloud, which revealed an extensive embedded, optically obscured

  13. Incremental Validity of the Myers-Briggs Type Indicator in Predicting Academic Major Selection of Undecided University Students

    ERIC Educational Resources Information Center

    Pulver, Chad A.; Kelly, Kevin R.

    2008-01-01

    This study examined the incremental validity of the Myers-Briggs Type Indicator (MBTI) as a predictor of academic major choice. Undecided university students were administered the MBTI and Strong Interest Inventory (SII). Their academic major choice was recorded at the end of their fourth semester and categorized as realistic, investigative,…

  14. The Relationship of the Myers-Briggs Type Indicator to Scores on the National Teacher's Examination. AIR Forum 1981 Paper.

    ERIC Educational Resources Information Center

    Pratt, Linda K.; And Others

    The relationship of the dimensions of the Myers-Briggs Type Indicator (MBTI) to scores on the National Teacher's Examination (NTE) was examined. The MBTI classifies people on each of four indices: extraversion/introversion, sensing/intuition, thinking/feeling, and judgment/perception. A sample of 111 students, 90 percent of whom were black,…

  15. The Relationship of the Myers-Briggs Type Indicator to Scores on the National Teacher's Examination. AIR Forum 1981 Paper.

    ERIC Educational Resources Information Center

    Pratt, Linda K.; And Others

    The relationship of the dimensions of the Myers-Briggs Type Indicator (MBTI) to scores on the National Teacher's Examination (NTE) was examined. The MBTI classifies people on each of four indices: extraversion/introversion, sensing/intuition, thinking/feeling, and judgment/perception. A sample of 111 students, 90 percent of whom were black,…

  16. Comparing University Students and Community College Students Learning Styles and Myers-Briggs Type Indicator (MBTI) Preferences.

    ERIC Educational Resources Information Center

    Herbster, Douglas L.; And Others

    This document reports on a study to determine if there is a pattern between specific learning styles and Myers-Briggs Type Indicator preferences. The learning style inventory used for the study, "The Teaching and Learning Styles Survey for Adolescents (TLC)," is based on Jungian style preferences--thinker, feeler, sensor, and…

  17. The Devil Is in the Detail Regarding the Efficacy of Reading Recovery: A Rejoinder to Schwartz, Hobsbaum, Briggs, and Scull

    ERIC Educational Resources Information Center

    Reynolds, Meree; Wheldall, Kevin; Madelaine, Alison

    2009-01-01

    This rejoinder provides comment on issues raised by Schwartz, Hobsbaum, Briggs and Scull (2009) in their article about evidence-based practice and Reading Recovery (RR), written in response to Reynolds and Wheldall (2007). Particular attention is paid to the processes and findings of the What Works Clearinghouse evaluation of RR. The suggestion…

  18. "Presidential Address." Political Pawns in an Educational Endgame: Reflections on Bryant, Briggs, and Some Twentieth-Century School Questions

    ERIC Educational Resources Information Center

    Graves, Karen

    2013-01-01

    "Newsweek" ran an article on "The Homosexual Teacher" in December 1978. At the end of a tumultuous two-year period framed by Anita Bryant's anti-gay campaign in South Florida and John Briggs' proposition to bar gay and lesbian educators from working in California public schools, reporters concluded, "Most homosexual…

  19. Considering Personality Type in Adult Learning: Using the Myers-Briggs Type Indicator in Instructor Preparation at PricewaterhouseCoopers

    ERIC Educational Resources Information Center

    Daisley, Richard J.

    2011-01-01

    This article explores the feasibility of using the Myers-Briggs Type Indicator (MBTI) as a framework for instructor development in a professional services training environment. It explores the consistency of MBTI with common adult learning theory, addresses questions on MBTI's reliability and validity, and explores the applicability of MBTI to the…

  20. Gathering the Force Fields of Energy in Student Affairs: Staff Development Using the Myers-Briggs Type Indicator.

    ERIC Educational Resources Information Center

    McNickle, Phyllis J.; Veltman, Gayle C.

    1988-01-01

    Discusses application of the Myers-Briggs Type Indicator (MBTI) as a staff development tool at Wichita State University in Kansas. Describes procedure for implementing the MBTI in staff development and presents results from MBTI use with 39 staff members. Recommends that student affairs divisions at other institutions use the MBTI in staff…

  1. "Presidential Address." Political Pawns in an Educational Endgame: Reflections on Bryant, Briggs, and Some Twentieth-Century School Questions

    ERIC Educational Resources Information Center

    Graves, Karen

    2013-01-01

    "Newsweek" ran an article on "The Homosexual Teacher" in December 1978. At the end of a tumultuous two-year period framed by Anita Bryant's anti-gay campaign in South Florida and John Briggs' proposition to bar gay and lesbian educators from working in California public schools, reporters concluded, "Most homosexual…

  2. The Myers-Briggs Type Indicator[R] and Mainstream Psychology: Analysis and Evaluation of an Unresolved Hostility

    ERIC Educational Resources Information Center

    Lloyd, John B.

    2012-01-01

    The Myers-Briggs Type Indicator (MBTI[R]) is widely used as a staff-development tool in the business and voluntary sectors. Its Psychological Type approach is found to be a valuable aid to understanding self and others and thus to enhancing effective team-working. This continuing and growing popularity is surprising in view of the disdain with…

  3. A Review of the Myers-Briggs Type Inventory: A Potential Training Tool for Human Services Organizations.

    ERIC Educational Resources Information Center

    Aviles, Christopher B.

    The Myers-Briggs Type Inventory (MBTI) can be helpful in personal, career, and marriage counseling; conflict and stress management; team building; and understanding managerial and learning styles. It has great potential to be utilized in human services organizations for training purposes because it offers a way to conceptualize employee…

  4. The Myers-Briggs Type Indicator as a Tool to Facilitate Learning Outcomes for Team Building in the Classroom

    ERIC Educational Resources Information Center

    Berry, Priscilla; Wood, Cindy; Thornton, Barry

    2007-01-01

    Globalization and domestic competition are forcing businesses to rethink the human resources utilization process, and one method for considering again this challenge is creating a team culture. One key to this process for human resources development is the understanding of how to create the most successful teams. The use of the Myers-Briggs Type…

  5. Considering Personality Type in Adult Learning: Using the Myers-Briggs Type Indicator in Instructor Preparation at PricewaterhouseCoopers

    ERIC Educational Resources Information Center

    Daisley, Richard J.

    2011-01-01

    This article explores the feasibility of using the Myers-Briggs Type Indicator (MBTI) as a framework for instructor development in a professional services training environment. It explores the consistency of MBTI with common adult learning theory, addresses questions on MBTI's reliability and validity, and explores the applicability of MBTI to the…

  6. The Myers-Briggs Type Indicator as a Tool to Facilitate Learning Outcomes for Team Building in the Classroom

    ERIC Educational Resources Information Center

    Berry, Priscilla; Wood, Cindy; Thornton, Barry

    2007-01-01

    Globalization and domestic competition are forcing businesses to rethink the human resources utilization process, and one method for considering again this challenge is creating a team culture. One key to this process for human resources development is the understanding of how to create the most successful teams. The use of the Myers-Briggs Type…

  7. A Longitudinal Study of Learning Style Preferences on the Myers-Briggs Type Indicator and Learning Style Inventory

    ERIC Educational Resources Information Center

    Salter, Daniel W.; Evans, Nancy J.; Forney, Deanna S.

    2006-01-01

    The stability of learning style preferences, as measured by the Myers-Briggs Type Indicator (MBTI) and Learning Style Inventory (LSI), was examined using a configural frequency analysis of differences. Thirteen cohorts (222 graduate students) completed the instruments 3 times during their programs. Implications for use of learning style measures…

  8. Incremental Validity of the Myers-Briggs Type Indicator in Predicting Academic Major Selection of Undecided University Students

    ERIC Educational Resources Information Center

    Pulver, Chad A.; Kelly, Kevin R.

    2008-01-01

    This study examined the incremental validity of the Myers-Briggs Type Indicator (MBTI) as a predictor of academic major choice. Undecided university students were administered the MBTI and Strong Interest Inventory (SII). Their academic major choice was recorded at the end of their fourth semester and categorized as realistic, investigative,…

  9. Log-Linear Techniques for the Analysis of Categorical Data: A Demonstration with the Myers-Briggs Type Indicator.

    ERIC Educational Resources Information Center

    Salter, Daniel W.

    2003-01-01

    Log-linear analysis (LLA) techniques for categorical variables are demonstrated and evaluated using data from the Myers-Briggs Type Indicator. Symmetrical LLA and asymmetrical LLA address questions of association and inference, respectively. Configural frequency analysis is examined as a strategy for whole types research. LLA approaches seem…

  10. The Myers-Briggs Type Indicator[R] and Mainstream Psychology: Analysis and Evaluation of an Unresolved Hostility

    ERIC Educational Resources Information Center

    Lloyd, John B.

    2012-01-01

    The Myers-Briggs Type Indicator (MBTI[R]) is widely used as a staff-development tool in the business and voluntary sectors. Its Psychological Type approach is found to be a valuable aid to understanding self and others and thus to enhancing effective team-working. This continuing and growing popularity is surprising in view of the disdain with…

  11. A Longitudinal Study of Learning Style Preferences on the Myers-Briggs Type Indicator and Learning Style Inventory

    ERIC Educational Resources Information Center

    Salter, Daniel W.; Evans, Nancy J.; Forney, Deanna S.

    2006-01-01

    The stability of learning style preferences, as measured by the Myers-Briggs Type Indicator (MBTI) and Learning Style Inventory (LSI), was examined using a configural frequency analysis of differences. Thirteen cohorts (222 graduate students) completed the instruments 3 times during their programs. Implications for use of learning style measures…

  12. The Multifactorial Nature of Extraversion-Introversion in the Myers-Briggs Type Indicator and Eysenck Personality Inventory.

    ERIC Educational Resources Information Center

    Sipps, Gary J.; Alexander, Ralph A.

    1987-01-01

    The construct validity of extraversion-introversion was explored, as measured by the Myers Briggs Type Indicator (MBTI) and the Eysenck Personality Inventory. Findings supported the complexity of extraversion-introversion. Two MBTI scales, Extraversion Introversion and Judging Perceiving, were factorially valid measures of impulsivity…

  13. Log-Linear Techniques for the Analysis of Categorical Data: A Demonstration with the Myers-Briggs Type Indicator.

    ERIC Educational Resources Information Center

    Salter, Daniel W.

    2003-01-01

    Log-linear analysis (LLA) techniques for categorical variables are demonstrated and evaluated using data from the Myers-Briggs Type Indicator. Symmetrical LLA and asymmetrical LLA address questions of association and inference, respectively. Configural frequency analysis is examined as a strategy for whole types research. LLA approaches seem…

  14. The Joanna Briggs Institute Best Practice Information Sheet: music as an intervention in hospitals.

    PubMed

    2011-03-01

    This Best Practice Information Sheet aims to synthesize the best-available evidence on music as a therapeutic intervention for the management of anxiety or pain related to procedural or operative interventions. The information that is contained in this sheet has been derived from studies that were included in a systematic review that was conducted by The Joanna Briggs Institute. The original references can be sourced from the systematic review. Music as a therapeutic intervention is a development largely of the mid-20th century; however, it has existed in various forms in most cultures for many centuries. The Best Practice Information Sheet includes music-listening before a procedure or operation, during a procedure or operation, and after a procedure or operation. It excludes other forms of music therapy. Several recommendations for practice are made.

  15. Myers Briggs Type Indicator and Tridimensional Personality Questionnaire differences between bipolar patients and unipolar depressed patients.

    PubMed

    Janowsky, D S; Morter, S; Hong, L; Howe, L

    1999-12-01

    The current study was designed to compare personality differences between bipolar patients and unipolar depressed patients, as evaluated on the Myers Briggs Type Indicator (MBTI) and the Tridimensional Personality Questionnaire (TPQ). A group of bipolar and a group of unipolar depressed patients filled out the MBTI, the TPQ, the Beck Depression Inventory, and the CAGE questionnaire. The two groups were compared with each other as to responses on the above surveys, and subgroups of bipolar depressed and bipolar patients with manic symptoms were also compared. Bipolar patients were found to be significantly more extroverted (p = 0.004) and less judging (p = 0.007) on the MBTI. They were significantly more novelty seeking (p = 0.004) and less harm avoidant (p = 0.002) on the TPQ. Of the above differences, only the TPQ harm avoidance scale appeared strongly linked to the patients' level of depression. Significant differences in personality exist between bipolar disorder and unipolar depressed patients.

  16. Relationship between Myers-Briggs psychological traits and use of course objectives in anatomy and physiology.

    PubMed

    Harasym, P H; Leong, E J; Lucier, G E; Lorscheider, F L

    1996-06-01

    The results from the Myers-Briggs Type Indicator (MBTI), which identified preferred psychological traits for 131 nursing students, were compared to their usage levels of course objectives in an undergraduate course in anatomy and physiology. The three usage levels (user, occasional user, and nonuser) were also compared to exam scores in the course, overall grade point averages (GPA) in first-year nursing, and the various psychological traits measured by the MBTI. A multivariate analysis of variance (MANOVA) indicated that users of objectives achieved significantly higher exam scores and maintained a higher GPA than occasional and nonusers. The MANOVA also indicated that users of course objectives preferred a sensing judging modality, whereas nonusers preferred an intuiting perceiving style to guide their studying and learning.

  17. Bipolarity in Jungian type theory and the Myers-Briggs Type Indicator.

    PubMed

    Girelli, S A; Stake, J E

    1993-04-01

    The standard form of the Myers-Briggs Type Indicator (MBTI; Myers & McCaulley, 1985) was constructed to measure introversion/extroversion, sensing/intuiting, and thinking/feeling as single, bipolar dimensions. We tested this assumption of bipolarity with a Likert form of the MBTI that allowed for the independent assessment of each attitude and function. A total of 106 female and 59 male undergraduate and graduate students completed the standard and Likert MBTI forms approximately 3 weeks apart. Evidence for the bipolarity of the introversion/extroversion dimension was weak, and findings did not support the bipolarity of the sensing/intuiting or thinking/feeling dimensions. Results provide evidence that high negative correlations within MBTI dimensions are an artifact of its forced-choice format. Implications of the findings for typology measurement are discussed.

  18. Myers-Briggs psychological type and achievement in anatomy and physiology.

    PubMed

    Harasym, P H; Leong, E J; Juschka, B B; Lucier, G E; Lorscheider, F L

    1995-06-01

    Results from the Myers-Briggs Type Indicator (MBTI) for 259 nursing students were compared with their achievement on examinations in an undergraduate course in anatomy and physiology. Factor analysis demonstrated that no relationship existed between any of the eight individual personality traits purported to be measured by MBTI (i.e., E, Extrovert; I, Introvert; S, Sensing; N, Intuition; T, Thinking; F, Feeling; J, Judging; P, Perceiving) and examination scores in this course. The analysis also showed that the bipolar scales S vs. N and J vs. P collapsed into a single bipolar scale (S/J vs. N/P). This means that the MBTI is only capable of measuring three bipolar scales of personality traits instead of four scales as currently claimed. Contrary to other findings, results from an analysis of variance revealed no meaningful relationship between course achievement and psychological types.

  19. Bimodal score distributions and the Myers-Briggs Type Indicator: fact or artifact?

    PubMed

    Bess, Tammy L; Harvey, Robert J

    2002-02-01

    We examined Myers-Briggs Type Indicator (MBTI) score distributions computed using item response theory (IRT) to assess the generalizability of earlier bimodality reports that have been cited in support of the "type" versus "trait" view of personality. Using the BILOG IRT program to score a sample of approximately 12,000 individuals who participated in leadership development programs, theta score distributions for the 4 dimensions of the MBTI computed using 10 (the BILOG default) versus 50 quadrature points were compared. Results indicated that past reports of bimodality were artifacts caused by BILOG's default use of a small number of quadrature points; when larger numbers of points were used, score distributions became strongly center-weighted. Although our findings are not supportive of the "type"-based hypothesis, the extremely high correlations between theta scores (rs > .996) suggest that no practical differences would be expected as a function of the number-of-quadrature-points decision.

  20. Thirumŭlar--pioneer of the immunology concept.

    PubMed

    Rajasekaran, R; Narayana, Ala

    2006-01-01

    Extraordinary longevity of life, made possible by repeated reading and following of the text Thirumandiram 3000 - written by great Siddhar Thirumŭlar. He the Prince of Mystics is one of the 18 luminous Siddhars and the first and foremost #1 Siva śiddhăndi. Historians and scholars predicted his life period between 5th to 8th centuries AD. In his teachings, he explained the kinds of 'Thavam' (Yoga) and he insisted the #2 'Kăya siddhi'. Thousands of years ago, he wrote in detail about Anatomy of microcosm, Siddha physiology, Humoural pathology, Science of pulse, Microcosmic Atom theory, Immunology concept and Immortalization of our body. His marvelous text Thirumandiram deals with Medical science, Life science, Natural science and Divine. In this article authors, discuss about the biography of Thirumŭlar and his medical works.

  1. Stability Training for Convolutional Neural Nets in LArTPC

    NASA Astrophysics Data System (ADS)

    Lindsay, Matt; Wongjirad, Taritree

    2017-01-01

    Convolutional Neural Nets (CNNs) are the state of the art for many problems in computer vision and are a promising method for classifying interactions in Liquid Argon Time Projection Chambers (LArTPCs) used in neutrino oscillation experiments. Despite the good performance of CNN's, they are not without drawbacks, chief among them is vulnerability to noise and small perturbations to the input. One solution to this problem is a modification to the learning process called Stability Training developed by Zheng et al. We verify existing work and demonstrate volatility caused by simple Gaussian noise and also that the volatility can be nearly eliminated with Stability Training. We then go further and show that a traditional CNN is also vulnerable to realistic experimental noise and that a stability trained CNN remains accurate despite noise. This further adds to the optimism for CNNs for work in LArTPCs and other applications.

  2. The liquid annular reactor system (LARS) for deep space exploration

    NASA Astrophysics Data System (ADS)

    Maise, George; Paniagua, John; Powell, James R.; Ludewig, Hans; Todosow, Michael

    1999-05-01

    A new propulsion concept for high Δ V space missions, termed LARS (Liquid Annular Reactor System), uses liquid nuclear fuel elements to heat hydrogen propellant to very high temperatures (-6000 K). The molten fuel is contained in a lower-temperature solid container which rotates to stabilize and hold in the liquid layer by centripetal force. Containment of ultra high temperature molten refractories, using this method, has been experimentally demonstrated by A.V. Grosse. The specific impulse of a rocket exhausting hydrogen at 6000 K is 2000 seconds, approximately double that of solid-core nuclear rockets. A LARS-powered space probe could accomplish extra-solar missions to 550 A.U. in approximately 35 years.

  3. LAR: More Than Just a System, It is a Mindset

    DTIC Science & Technology

    2011-04-26

    8217 as: prepared in cooperation with; translation of; report supersedes; old edition number, etc. 14. ABSTRACT. A brief (approximately 200. words ...factual summary of the most significant information. 15. SUBJECT TERMS. Key words or phrases identifying major concepts in the report. 16. SECURITY...Military Operations in Urban Terrain ( MOUT ) and what should be considered in the employment ofLAR units?5 The MCWP 3-14 is woefully inadequate in defining

  4. Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury

    PubMed Central

    Xu, Bin; Park, Dongsun; Ohtake, Yosuke; Li, Hui; Hayat, Umar; Li, Junjun; Selzer, Michael E.; Longo, Frank M.; Li, Shuxin

    2014-01-01

    Extracellular matrix molecule chondroitin sulfate proteoglycans (CSPGs) are highly upregulated in scar tissues and form a potent chemical barrier for CNS axon regeneration. Recent studies support that the receptor protein tyrosine phosphatase σ (PTPσ) and its subfamily member leukocyte common antigen related phosphatase (LAR) act as transmembrane receptors to mediate CSPG inhibition. PTPσ deficiency increased regrowth of ascending axons into scar tissues and descending corticospinal tract (CST) axons into the caudal spinal cord after spinal cord injury (SCI). Pharmacological LAR inhibition enhanced serotonergic axon growth in SCI mice. However, transgenic LAR deletion on axon growth in vivo and role of LAR in regulating regrowth of other fiber tracts have not been studied. Here, we studied role of LAR in restricting regrowth of injured descending CNS axons in deficient mice. LAR deletion increased regrowth of serotonergic axons into scar tissues and caudal spinal cord after dorsal overhemitransection. LAR deletion also stimulated regrowth of CST fibers into the caudal spinal cord. LAR protein was upregulated days to weeks after injury and co-localized to serotonergic and CST axons. Moreover, LAR deletion improved functional recovery by increasing BMS locomotor scores and stride length and reducing grid walk errors. This is the first transgenic study that demonstrates crucial role of LAR in restricting regrowth of injured CNS axons. PMID:25220840

  5. The First Pion-Ar Cross-Section Measurement with the LArIAT Experiment

    SciTech Connect

    Nutini, Irene

    2016-01-01

    A complete understanding of neutrinos properties requires a study and a characterization of the interactions of the daughter particles created in a neutrino-nucleus interaction. The Liquid Argon In A Testbeam (LArIAT) experiment is a small-scale liquid argon detector situated in the Fermilab Test Beam Facility. The LArIAT experiment is exposed to a tertiary beam comprised of mostly pions along with a mix of muons, protons, kaons, and electrons. LArIAT's goal is to characterize the response of the LArTPC to known incoming charged particles and measure their interactions in Argon, in order to understand their cross-sections and to help developing and tuning simulations and reconstruction algorithms for LArTPC neutrino experiments. The world's rst measurement of a pion cross-section on an Argon target, made with the LArIAT detector, is presented here.

  6. LArIAT: Worlds First Pion-Argon Cross-Section

    SciTech Connect

    Hamilton, Pip

    2016-11-02

    The LArIAT experiment has performed the world's first measurement of the total charged-current pion cross-section on an argon target, using the repurposed ArgoNeuT detector in the Fermilab test beam. Presented here are the results of that measurement, along with an overview of the LArIAT experiment and details of the LArIAT collaboration's plans for future measurements.

  7. A Direct Comparison of HI and Lyα Morphologies in Two LARS Galaxies

    NASA Astrophysics Data System (ADS)

    Fitzgibbon, Kathleen; Cannon, John M.; Freeland, Emily; Hayes, Matthew; Östlin, Göran; LARS Team

    2016-01-01

    The Lyman-Alpha Reference Sample (LARS) and its extension (eLARS) represent an exhaustive campaign to reverse-engineer galaxies. The main goal is to understand how Lyα is transported within galaxies: what fraction of it escapes, and what physical properties affect Lyα morphology and radiative transport (e.g. dust and gas content, metallicity, kinematics, properties of the stellar population). Neutral hydrogen emission, which can be used to determine a galaxy's structure and kinematics, was observed using the B and C configurations of the Very Large Array in two galaxies from the sample: LARS02 and LARS09. Images of the HI mass surface density and of the intensity weighted HI velocity field were created at angular scales of ~8 arcseconds. Extended HI gas is detected at high significance up to ˜30 kpc from the optical body of LARS02. LARS09 has a severely disturbed optical morphology; our new HI observations reveal that LARS09 is interacting with the nearby field galaxy SDSS J082353.65+280622.2. In combination with direct imaging of the Lyα morphology from the Hubble Space Telescope, this program has produced the first direct comparison of Lyα and HI morphologies. These observations demonstrate concept for a significant observational campaign that will produce similar comparisons in the remaining 40 LARS+eLARS galaxies.KF was partially supported by a Science Education Award from the Howard Hughes Medical Institute (HHMI) to Macalester College.

  8. Conducting systematic reviews of association (etiology): The Joanna Briggs Institute's approach.

    PubMed

    Moola, Sandeep; Munn, Zachary; Sears, Kim; Sfetcu, Raluca; Currie, Marian; Lisy, Karolina; Tufanaru, Catalin; Qureshi, Rubab; Mattis, Patrick; Mu, Peifan

    2015-09-01

    The systematic review of evidence is the research method which underpins the traditional approach to evidence-based healthcare. There is currently no uniform methodology for conducting a systematic review of association (etiology). This study outlines and describes the Joanna Briggs Institute's approach and guidance for synthesizing evidence related to association with a predominant focus on etiology and contributes to the emerging field of systematic review methodologies. It should be noted that questions of association typically address etiological or prognostic issues.The systematic review of studies to answer questions of etiology follows the same basic principles of systematic review of other types of data. An a priori protocol must inform the conduct of the systematic review, comprehensive searching must be performed and critical appraisal of retrieved studies must be carried out.The overarching objective of systematic reviews of etiology is to identify and synthesize the best available evidence on the factors of interest that are associated with a particular disease or outcome. The traditional PICO (population, interventions, comparators and outcomes) format for systematic reviews of effects does not align with questions relating to etiology. A systematic review of etiology should include the following aspects: population, exposure of interest (independent variable) and outcome (dependent variable).Studies of etiology are predominantly explanatory or predictive. The objective of reviews of explanatory or predictive studies is to contribute to, and improve our understanding of, the relationship of health-related events or outcomes by examining the association between variables. When interpreting possible associations between variables based on observational study data, caution must be exercised due to the likely presence of confounding variables or moderators that may impact on the results.As with all systematic reviews, there are various approaches to

  9. Investigation into the efficacy and safety of octreotide LAR in Japanese patients with acromegaly: Shizuoka study.

    PubMed

    Oki, Yutaka; Inoue, Tatsuhide; Imura, Mitsuo; Tanaka, Tokutaro; Genma, Rieko; Iwabuchi, Masayasu; Hataya, Yuji; Matsuzawa, Yuji; Iino, Kazumi; Nishizawa, Shigeru; Nakamura, Hirotoshi

    2009-01-01

    The efficacy and safety of the long-acting repeatable formulation of octreotide (OCT-LAR) treatment in patients suffering from acromegaly was investigated retrospectively in Shizuoka prefecture, Japan. Thirty patients (11 male, 19 female; average age, 48.9 years old), 29 of whom had undergone transsphenoidal surgery previously, were treated with OCT-LAR. OCT-LAR was injected i.m. every 4 weeks with an intended protocol of 20 mg over 24 months, however, 46.7% of patients required the dose of OCT-LAR to be increased. The final average dose of OCT-LAR was 25.0 +/- 6.8 mg. Administering OCT-LAR significantly decreased serum GH and insulin-like growth factor 1 (IGF-1) levels (from 13.7 +/- 11.9 to 5.8 +/- 7.3 microg/L and from 585 +/- 263 to 339 +/- 193.7 microg/L after 3 months, respectively). Among patients treated with OCT-LAR, 56.7% expressed LAR did not have a negative effect on glucose tolerance when hemoglobin A1c was used as a marker. A gallbladder polyp was found only in 1 patient but it was uncertain whether OCT-LAR was involved in its development because the patient was not examined before OCT-LAR treatment. There were no abnormalities on liver function tests in any patients. In conclusion, our results showed that OCT-LAR was safe and effective as a therapeutic option for Japanese patients with acromegaly in a postoperative setting, by controlling the disease activity.

  10. The association between Myers-Briggs Type Indicator and Psychiatry as the specialty choice.

    PubMed

    Yang, Chong; Richard, George; Durkin, Martin

    2016-02-06

    The purpose of this pilot study is to examine the association between Myers-Briggs Type Indicator (MBTI) and prospective psychiatry residents. Forty-six American medical schools were contacted and asked to participate in this study. Data were collected and an aggregated list was compiled that included the following information: date of MBTI administration, academic year, MBTI form/version, residency match information and student demographic information. The data includes 835 American medical students who completed the MBTI survey and matched into a residency training program in the United States. All analyses were performed using R 3.1.2. The probability of an introvert matching to a psychiatry residency is no different than that of an extravert (p= 0.30). The probability of an intuitive individual matching to a psychiatry residency is no different than that of a sensing type (p=0.20). The probability of a feeling type matching to a psychiatry residency is no different than that of a thinking type (p= 0.50). The probability of a perceiving type matching to a psychiatry residency is no different than that of a judging type (p= 0.60). Further analyses may elicit more accurate information regarding the personality profile of prospective psychiatry residents. The improvement in communication, team dynamics, mentor-mentee relationships and reduction in workplace conflicts are possible with the awareness of MBTI personality profiles.

  11. Pollen dispersal by catapult: Experiments of Lyman J. Briggs on the flower of mountain laurel

    USGS Publications Warehouse

    Nimmo, John R.; Hermann, Paula M.; Kirkham, M.B.; Landa, Edward R.

    2014-01-01

    The flower of Kalmia latifolia L. employs a catapult mechanism that flings its pollen to considerable distances. Physicist Lyman J. Briggs investigated this phenomenon in the 1950s after retiring as longtime director of the National Bureau of Standards, attempting to explain how hydromechanical effects inside the flower’s stamen could make it possible. Briggs’s unfinished manuscript implies that liquid under negative pressure generates stress, which, superimposed on the stress generated from the flower’s growth habit, results in force adequate to propel the pollen as observed. With new data and biophysical understanding to supplement Briggs’s experimental results and research notes, we show that his postulated negative-pressure mechanism did not play the exclusive and crucial role that he credited to it, though his revisited investigation sheds light on various related processes. Important issues concerning the development and reproductive function of Kalmia flowers remain unresolved, highlighting the need for further biophysical advances.

  12. Myers-Briggs type and medical specialty choice: a new look at an old question.

    PubMed

    Stilwell, N A; Wallick, M M; Thal, S E; Burleson, J A

    2000-01-01

    Career development of health professionals is one of many uses of Myers-Briggs Type Indicator (MBTI), with many studies reported from the 1950s. Since 1977, no large-scale effort to collect data on the medical school population has been reported. To determine (a) changes in MBTI profiles of medical students over time, (b) differences between the profiles of men and women and the effects of the increased number of women in medical school, (c) possible associations between type and career choices, and (d) possible type differences of graduates selecting primary care and specialties. Twelve U.S. schools with data on 3,987 students contributed to a database of their graduates' MBTI type and specialty choice at Match. Compared with data from the 1950s, the type distribution of physicians has remained fairly stable, save for a trend toward more judging types. Women in medicine today are more representative of the general population on the feeling dimension than earlier, when medicine was more male-dominated. Women are more likely than men to choose primary care specialties, as are those with preference for introversion and feeling. Feeling types choose Family Medicine significantly more often than thinking types; male, extraverted, and thinking types choose surgical specialties. Of those selecting nonprimary care, male, extraverted, and thinking types choose surgical specialties significantly more than women, introverted, and feeling types. Type remains useful for understanding how some aspects of personality relate to medical specialty choice.

  13. The effect of counseling for interpersonal relationship using myers-briggs type indicator.

    PubMed

    Jang, Seon Suk; Kim, Bong Jo; Ju, Young Tae; Woo, Hyang Ok; Han, Jae Hee; Cho, Gyeong Jae; Hong, Soon Chan

    2011-03-01

    There are large differences between medical school curricula and those of other disciplines and graduate schools. Counseling program is designed to help participants understand their innate tendencies and have indirect experiences with the 16 Myers-Briggs Type Indicator (MBTI) types, which can lead to better interpersonal relationships. The experimental and control groups, which were sampled randomly, comprised 34 students each. Each group was consisted of 17 females and 17 males. We implemented a counseling program (understanding oneself, understanding others) only to the experimental group, not the control group. The effects of the program were analyzed by t-test and analysis of covariance (ANCOVA). The data were analyzed using SPSS 17.0 Window. For the Human relationship scale as a whole, the experimental group showed an increase from 3.641 to 3.846 (p=0.001). With regard to the subcategories, satisfaction increased from 3.705 to 4.022 (p=0.000), trust increased from 3.480 to 3.715 (p=0.015), intimacy increased from 3.833 to 4.019 (p=0.007), and openness increased from 3.435 to 3.700 (p=0.006). This program improved interpersonal relationships by helping new students understand each other, build a rapport, and understand their personalities well with open minded attitudes. Their relationships gradually became more intimate than awkward through this program.

  14. Pilot study of Myers Briggs Type Indicator personality profiling in emergency department senior medical staff.

    PubMed

    Boyd, Russell; Brown, Terry

    2005-06-01

    To study the viability of using the Myers Briggs Type Indicator (MBTI) in senior ED medical staff and to examine what trends, if any, in personality types exist within the specialty. A pilot cross-sectional survey was undertaken during which a standard MBTI questionnaire was sent anonymously to a convenience sample of senior ED medical staff in Tasmania and South Australia. Completed surveys after a second mailing were analysed and the results collated. Of 82 senior ED medical staff surveyed, 68 returned completed questionnaires (response rate 83%). The single most common personality group in the cohort was the (Extrovert/Intuitive/Thinking/Judging) ENTJ type exhibited by 12 (17.7%, 95% CI 9.4-28.7%) clinicians in the cohort. This group is present at a rate of 3% in the general population. In terms of individual traits, Introversion was exhibited by 33 (48.5%, 95% CI 36.2-61%), Intuitive traits by 40 (58.8%, 95% CI 46.2-70.6%), Thinking traits by 40 (58.8%, 95% CI 46.2-70.6%) and Judging traits by 53 (77.9%, 95% CI 66.2-87.1%) of our cohort of senior ED medical staff. Our senior ED medical staff cohort suggests notable variations from the general population in terms of their MBTI profiles.

  15. The association between Myers-Briggs Type Indicator and Psychiatry as the specialty choice

    PubMed Central

    Richard, George; Durkin, Martin

    2016-01-01

    Objectives The purpose of this pilot study is to examine the association between Myers-Briggs Type Indicator (MBTI) and prospective psychiatry residents. Methods Forty-six American medical schools were contacted and asked to participate in this study. Data were collected and an aggregated list was compiled that included the following information: date of MBTI administration, academic year, MBTI form/version, residency match information and student demographic information. The data includes 835 American medical students who completed the MBTI survey and matched into a residency training program in the United States. All analyses were performed using R 3.1.2. Results The probability of an introvert matching to a psychiatry residency is no different than that of an extravert (p= 0.30). The probability of an intuitive individual matching to a psychiatry residency is no different than that of a sensing type (p=0.20). The probability of a feeling type matching to a psychiatry residency is no different than that of a thinking type (p= 0.50). The probability of a perceiving type matching to a psychiatry residency is no different than that of a judging type (p= 0.60). Conclusions Further analyses may elicit more accurate information regarding the personality profile of prospective psychiatry residents. The improvement in communication, team dynamics, mentor-mentee relationships and reduction in workplace conflicts are possible with the awareness of MBTI personality profiles. PMID:26851600

  16. The relationship between life satisfaction, self-consciousness, and the Myers-Briggs type inventory dimensions.

    PubMed

    Harrington, R; Loffredo, D A

    2001-07-01

    The study was an investigation of the relationship between psychological well-being, life satisfaction, self-consciousness, and the four Myers-Briggs Type Indicator dimensions (MBTI; I. B. Myers & M. H. McCaulley, 1985). The participants were 97 college students (79 women and 18 men whose mean age was 31.4 years). All the students were administered four instruments, the Psychological Well-Being Inventory (C. D. Ryff, 1989), the Satisfaction With Life Scale (E. Diener, R. A. Emmons, R. J. Larsen, & S. Griffin, 1985), the Self-Consciousness Scale-Revised (M. F. Scheier & C. S. Carver, 1985), and the MBTI (Form G Self-Scoring). MANOVAs revealed significant differences on three of the four dimensions of the MBTI with extraverts showing higher psychological well-being and life satisfaction and lower self-consciousness than introverts. Intuition types scored higher in psychological well-being and lower in self-consciousness than Sensing types. Judging types scored higher in psychological well-being than Perceiving types. Correlational analyses showed that most dimensions of psychological well-being were negatively related to self-consciousness. The relationship between life satisfaction and personality variables is discussed.

  17. Personality types of family practice residents as measured by the Myers-Briggs type indicator.

    PubMed

    Harris, D L; Ebbert, P

    1985-01-01

    This study was initiated to test the hypothesis that individuals currently choosing family practice as a career are likely to have different personality types than those who previously pursued general practice. Incoming residents to the University of Utah Family Practice Residency Program were compared to a group of private primary care physicians serving rural areas. Personality types were determined by administering the Myers-Briggs Type Indicator to both groups. Results showed that the current resident group differed significantly from the primary care physician group and that the residents' personality types were similar to personality types of faculty in other studies. This raises the concern that many family practice residents may not choose to practice in underserved areas. Further studies need to follow personality types through medical school and residency training and into practice to help determine which prospective physicians are likely to choose a primary care career and a rural practice. This information may be useful in health manpower planning and in examining admissions policies of medical schools and residencies.

  18. MicroBooNE, A Liquid Argon Time Projection Chamber (LArTPC) Neutrino Experiment

    SciTech Connect

    Katori, Teppei

    2011-07-01

    Liquid Argon time projection chamber (LArTPC) is a promising detector technology for future neutrino experiments. MicroBooNE is a upcoming LArTPC neutrino experiment which will be located on-axis of Booster Neutrino Beam (BNB) at Fermilab, USA. The R&D efforts on this detection method and related neutrino interaction measurements are discussed.

  19. Association of LAR-like receptor protein tyrosine phosphatases with an enabled homolog in Hirudo medicinalis.

    PubMed

    Biswas, Subhas C; Dutt, Anindita; Baker, Michael W; Macagno, Eduardo R

    2002-12-01

    Receptor protein tyrosine phosphatases (RPTPs) are thought to play important functions in pathfinding and target recognition by growing neuronal processes. The leech RPTPs HmLAR1 and HmLAR2 are expressed selectively by central neurons, Comb cells, and peripheral muscle tissues in the Hirudo medicinalis embryo. To explore the functions of HmLARs, we have sought to determine their physiological substrates. We report here the cloning and embryonic expression of Lena, the leech homolog of Enabled, a cytosolic protein implicated in actin-based cell motility. Lena is expressed in embryonic central neurons and in the Comb cell. We present experimental evidences indicating that Lena associates selectively with the intracellular domain of HmLAR1 and HmLAR2. Additionally, RNA interference (RNAi) of HmLAR1 in intact leech embryos leads to the hyperphosphorylation of Lena. We propose, therefore, that Lena is an in vivo substrate of HmLAR1 in neurons and perhaps of HmLAR2 in the Comb cells.

  20. Personality types of otolaryngology resident applicants as described by the Myers-Briggs Type Indicator.

    PubMed

    Zardouz, Shawn; German, Michael A; Wu, Edward C; Djalilian, Hamid R

    2011-05-01

    To assess the personality types of applicants to a single otolaryngology residency program using the Myers- Briggs Type Indicator. The personality types were compared with those of the general population and with physicians in other medical specialties. Cross-sectional survey. University hospital. A personality survey was emailed to 327 resident physician applicants over 2 consecutive years (2008- 2009). Analysis was accomplished by calculating prevalence estimates. Of the 327 anonymous surveys, 137 were completed (response rate = 42%). The Introverted/Sensing/Thinking/ Judging personality type was the most prevalent (14.6%), representing 13% of the general population. Prospective applicants displayed mostly Extroverted (E; 58%), Sensing (S; 54%), Thinking (T; 62%), and Judging (J; 61%) personality traits. Of the 16 personality types, statistically significant differences were found between otolaryngology resident applicants and the general population only for the Extroverted/Sensing/Thinking/ Perceiving (P = .002) personality type after correcting for multiple comparisons. The Intuitive (N; 46%) and Feeling (F; 38%) types correlated closely with the reported personality types of those individuals in non–primary care specialties, 47% and 28%, respectively. Extroverted (E) and Thinking (T) individuals appeared to prefer surgical specialties, which occurred in 58% and 62% of the applicants, respectively. There were no significant differences between male and female applicants. This study examines the personality types of medical students applying to an otolaryngology residency. The results support a highly structured, data-driven teaching preference among applicants. These results may allow for a better understanding of the personalities of medical students who are interested in otolaryngology.

  1. ATLAS LAr calorimeter performance and LHC Run-2 commissioning

    NASA Astrophysics Data System (ADS)

    Spettel, Fabian; Atlas Collaboration

    2016-07-01

    The ATLAS detector was built to study proton-proton collisions produced by the Large Hadron Collider (LHC) at a center of mass energy of up to 14 TeV. The Liquid Argon (LAr) calorimeters are used for all electromagnetic calorimetry as well as the hadronic calorimetry in the endcap and forward regions. They have shown excellent performance during the first LHC data taking campaign, from 2010 to 2012, so-called Run 1, at a peak luminosity of 8 ×1033cm-2s-1. During the next run, peak luminosities of 1.5 ×1034cm-2s-1 and even higher are expected at a 25 ns bunch spacing. Such a high collision rate may have an impact on the quality of the energy reconstruction which is attempted to be maintained at a high level using a calibration procedure described in this contribution. It also poses major challenges to the first level of the trigger system which is constrained to a maximal rate of 100 kHz. For Run-3, scheduled to start in 2019, instantaneous luminosity as high as 3 ×1034cm-2s-1 are foreseen imposing an upgrade of the LAr trigger system to maintain its performance. A demonstrator containing prototypes of the upgraded trigger electronic architecture has been installed on one of the barrel electromagnetic calorimeter readout front end crates to test it during the Run-2 campaign. The new architecture and its benefits for data taking will be discussed below as well as the results from first beam splash events.

  2. Cryopreservation of lar gibbon semen collected by manual stimulation.

    PubMed

    Takasu, Masaki; Morita, Natsumi; Tajima, Shunichiro; Almunia, Julio; Maeda, Masami; Kamiguchi, Takashi

    2016-07-01

    We confirmed ejaculation as a result of manual stimulation in a lar gibbon, and attempted to cryopreserve the semen using TES-Tris-egg yolk-based (TTE) extender. After measuring the amount of semen (g), we first diluted the semen with TTE extender, and calculated sperm concentration (sperm/ml), total sperm count (sperm), and progressive sperm motility (%). Then, we cooled diluted semen slowly to 4 °C over 2 h, and added an equal volume of secondary extender containing glycerol over 30 min. Finally, we flash-froze the semen solution by plunging into liquid nitrogen. In addition, we freeze-thawed the solution to determine the recovery rate of the motile sperm. Collection of semen was successful on four of the five occasions. The median (min-max) quantity of ejaculate was 0.19 g (0.09-0.26 g), the median sperm concentration was 1.38 × 10(9) sperm/ml (1.20-1.53 × 10(9) sperm/ml), and the median total sperm count was 0.26 × 10(9) sperm (0.11-0.40 × 10(9) sperm). Moreover, the median sperm motility immediately after ejaculation was 65 % (60-75 %), the median sperm motility after freeze-thawing was 30 % (25-35 %), and the median recovery rate was 42.3 % (40.0-58.3 %). We were able to (1) collect semen from a lar gibbon by manual stimulation, (2) reveal andrological findings regarding semen characteristics, and (3) preserve the genetic resource using TTE cryopreservation.

  3. A partial replication of Lippin (1990) using the Myers-Briggs type indicator with a sample of female prisoners.

    PubMed

    Long, C K; Lenoir, C; Phung, T; Witherspoon, A D

    1995-10-01

    A sample of 108 women incarcerated in a state prison who volunteered to participate in an employment seminar were given the Myers-Briggs Type Indicator. Comparison of the distribution of types here and in Myers and McCaulley's 1985 sample using a Selection Ratio Type Table for analysis indicated an overrepresentation of ISTJ, ISFJ, and ISTP. The ESFP and ESFJ types were underrepresented. Further analysis of the types and the relationship to criminal offense was not significant. Results are compared with those of Lippin from 1990.

  4. Nonintellective intelligence and personality: variance shared by the Constructive Thinking Inventory and the Myers-Briggs Type Indicator.

    PubMed

    Spirrison, C L; Gordy, C C

    1994-04-01

    The Constructive Thinking Inventory (CTI; Epstein & Meier, 1989), a recently developed scale assessing patterns of habitual everyday thoughts, was compared with the Myers-Briggs Type Indicator (MBTI; Myers & McCaulley, 1985) to ascertain areas of common variance. CTI and MBTI data from 65 men and 109 women were evaluated. A series of standard multiple regression procedures indicated that, in most instances, CTI scales were predictive of MBTI continuous scores, although gender mediated several of the effects. The results suggest that the variance assessed by the CTI is similar to that addressed by traditional measures of personality but that the CTI partitions the variance in an atypical, yet coherent, manner.

  5. Examination of the relations of the Myers-Briggs type indicator and the NEO-4 Personality Inventory in a Polish sample.

    PubMed

    Klinkosz, Waldemar; Iskra, Justyna

    2010-10-01

    The present study was designed to replicate McCrae and Costa's research findings on the relation of NEO-4 domains with the Myers-Briggs Type Indicator scales in a Polish sample of 300 psychology student volunteers (175 women, 125 men). Their mean age was 22.3 yr. (SD = 4.5). Correlations for scores on the MBTI scales with NEO-4 domains ranged from .72 to .02 for Extraversion, from -.60 to -.16 for Openness to experience, from -.56 to -.04 for Agreeableness, and from .55 to -.07 for Conscientiousness. Two domains assessed with the NEO-4 correspond to preferences measured by the Myers-Briggs Type Indicator.

  6. LARS Artificial Ligament Versus ABC Purely Polyester Ligament for Anterior Cruciate Ligament Reconstruction

    PubMed Central

    Iliadis, Dimitrios Ph.; Bourlos, Dimitrios N.; Mastrokalos, Dimitrios S.; Chronopoulos, Efstathios; Babis, George C.

    2016-01-01

    Background: Graft choice for anterior cruciate ligament (ACL) reconstruction is of critical importance. Various grafts have been used so far, with autografts long considered the optimal solution for the treatment of ACL-deficient knees. Limited data are available on the long-term survivorship of synthetic grafts. Purpose: To compare the functional outcome and survivorship of ACL reconstructions performed using the LARS (ligament augmentation and reconstruction system) ligament and the ABC (active biosynthetic composite) purely polyester ligament. Study Design: Case series; Level of evidence, 4. Methods: The results of 72 patients who underwent primary arthroscopic ACL reconstruction with the LARS ligament and 31 cases with an ABC purely polyester ligament were reviewed. The mean follow-up periods for the LARS and ABC groups were 9.5 and 5.1 years, respectively. A survivorship analysis of the 2 synthetic grafts was performed using the Kaplan-Meier method with a log-rank test (Mantel-Cox, 95% CI). Lysholm, Tegner activity, Knee injury and Osteoarthritis Outcome Score (KOOS), and International Knee Documentation Committee (IKDC) scores as well as laxity measurements obtained using a KT-1000 arthrometer were recorded for all intact grafts, and a Mann-Whitney U test was used for comparison reasons. Results: The rupture rates for LARS and ABC grafts were 31% (95% CI, 20%-42%) and 42% (95% CI, 25%-59%), respectively. For intact grafts, the mean Lysholm score was good for both groups (90 for the LARS group and 89 for the ABC group), with the majority of patients returning to their preinjury level of activities, and the mean IKDC score was 90 for the LARS group and 86 for the ABC group. Conclusion: The rupture rates of both LARS and ABC grafts were both high. However, the LARS ligament provided significantly better survivorship compared with the ABC ligament at short- to midterm follow-up (95% CI). PMID:27453894

  7. LARS Artificial Ligament Versus ABC Purely Polyester Ligament for Anterior Cruciate Ligament Reconstruction.

    PubMed

    Iliadis, Dimitrios Ph; Bourlos, Dimitrios N; Mastrokalos, Dimitrios S; Chronopoulos, Efstathios; Babis, George C

    2016-06-01

    Graft choice for anterior cruciate ligament (ACL) reconstruction is of critical importance. Various grafts have been used so far, with autografts long considered the optimal solution for the treatment of ACL-deficient knees. Limited data are available on the long-term survivorship of synthetic grafts. To compare the functional outcome and survivorship of ACL reconstructions performed using the LARS (ligament augmentation and reconstruction system) ligament and the ABC (active biosynthetic composite) purely polyester ligament. Case series; Level of evidence, 4. The results of 72 patients who underwent primary arthroscopic ACL reconstruction with the LARS ligament and 31 cases with an ABC purely polyester ligament were reviewed. The mean follow-up periods for the LARS and ABC groups were 9.5 and 5.1 years, respectively. A survivorship analysis of the 2 synthetic grafts was performed using the Kaplan-Meier method with a log-rank test (Mantel-Cox, 95% CI). Lysholm, Tegner activity, Knee injury and Osteoarthritis Outcome Score (KOOS), and International Knee Documentation Committee (IKDC) scores as well as laxity measurements obtained using a KT-1000 arthrometer were recorded for all intact grafts, and a Mann-Whitney U test was used for comparison reasons. The rupture rates for LARS and ABC grafts were 31% (95% CI, 20%-42%) and 42% (95% CI, 25%-59%), respectively. For intact grafts, the mean Lysholm score was good for both groups (90 for the LARS group and 89 for the ABC group), with the majority of patients returning to their preinjury level of activities, and the mean IKDC score was 90 for the LARS group and 86 for the ABC group. The rupture rates of both LARS and ABC grafts were both high. However, the LARS ligament provided significantly better survivorship compared with the ABC ligament at short- to midterm follow-up (95% CI).

  8. Role of PTPase LAR in EGF Receptor in the Mammary Gland

    DTIC Science & Technology

    2003-06-01

    development and tumorigenesis through negative modulation of EGFR signal transduction. In year 2, we demonstrated that LAR expression is regulated by...blocks the cell cycle. The central role of Akt regulation in this pathway is confirmed by recapitulating the effect with an adenovirus-mediated...epithelium. The experimental question to be asked is: Does LAR regulate pregnancy-dependent mammary gland maturation? This is very relevant to the hypothesis

  9. The receptor tyrosine phosphatase Lar regulates adhesion between Drosophila male germline stem cells and the niche.

    PubMed

    Srinivasan, Shrividhya; Mahowald, Anthony P; Fuller, Margaret T

    2012-04-01

    The stem cell niche provides a supportive microenvironment to maintain adult stem cells in their undifferentiated state. Adhesion between adult stem cells and niche cells or the local basement membrane ensures retention of stem cells in the niche environment. Drosophila male germline stem cells (GSCs) attach to somatic hub cells, a component of their niche, through E-cadherin-mediated adherens junctions, and orient their centrosomes toward these localized junctional complexes to carry out asymmetric divisions. Here we show that the transmembrane receptor tyrosine phosphatase Leukocyte-antigen-related-like (Lar), which is best known for its function in axonal migration and synapse morphogenesis in the nervous system, helps maintain GSCs at the hub by promoting E-cadherin-based adhesion between hub cells and GSCs. Lar is expressed in GSCs and early spermatogonial cells and localizes to the hub-GSC interface. Loss of Lar function resulted in a reduced number of GSCs at the hub. Lar function was required cell-autonomously in germ cells for proper localization of Adenomatous polyposis coli 2 and E-cadherin at the hub-GSC interface and for the proper orientation of centrosomes in GSCs. Ultrastructural analysis revealed that in Lar mutants the adherens junctions between hub cells and GSCs lack the characteristic dense staining seen in wild-type controls. Thus, the Lar receptor tyrosine phosphatase appears to polarize and retain GSCs through maintenance of localized E-cadherin-based adherens junctions.

  10. The receptor tyrosine phosphatase Lar regulates adhesion between Drosophila male germline stem cells and the niche

    PubMed Central

    Srinivasan, Shrividhya; Mahowald, Anthony P.; Fuller, Margaret T.

    2012-01-01

    The stem cell niche provides a supportive microenvironment to maintain adult stem cells in their undifferentiated state. Adhesion between adult stem cells and niche cells or the local basement membrane ensures retention of stem cells in the niche environment. Drosophila male germline stem cells (GSCs) attach to somatic hub cells, a component of their niche, through E-cadherin-mediated adherens junctions, and orient their centrosomes toward these localized junctional complexes to carry out asymmetric divisions. Here we show that the transmembrane receptor tyrosine phosphatase Leukocyte-antigen-related-like (Lar), which is best known for its function in axonal migration and synapse morphogenesis in the nervous system, helps maintain GSCs at the hub by promoting E-cadherin-based adhesion between hub cells and GSCs. Lar is expressed in GSCs and early spermatogonial cells and localizes to the hub-GSC interface. Loss of Lar function resulted in a reduced number of GSCs at the hub. Lar function was required cell-autonomously in germ cells for proper localization of Adenomatous polyposis coli 2 and E-cadherin at the hub-GSC interface and for the proper orientation of centrosomes in GSCs. Ultrastructural analysis revealed that in Lar mutants the adherens junctions between hub cells and GSCs lack the characteristic dense staining seen in wild-type controls. Thus, the Lar receptor tyrosine phosphatase appears to polarize and retain GSCs through maintenance of localized E-cadherin-based adherens junctions. PMID:22378638

  11. Somatostatin analog octreotide LAR in gastro-entero-pancreatic tumors.

    PubMed

    Oberg, Kjell

    2009-05-01

    Neuroendocrine tumors (NETs) are considered to be rare but, during the last two decades, their incidence and prevalence has considerably increased in gastro-entero-pancreatic (GEP) NETs. Most GEP-NETs express somatostatin receptors, which could be targets for treatment. The development of somatostatin analogs for treatment of functioning NETs was a revolution in the treatment of these patients and is still a cornerstone for managing hormone-related clinical symptoms. Furthermore, somatostatin analogs have also demonstrated an anti-tumor effect, with stabilization of tumor growth over long periods of time. The development of a long-acting formulation of octreotide long-acting release (LAR) significantly improved the quality of life for patients with functioning NETs in terms of necessitating only monthly injections. The side effects are few and easily manageable. In the future, somatostatin analogs will continue to be a major treatment option for functioning NETs, but will be combined with other biologicals, such as a-interferons, mTOR inhibitors and VEGF inhibitors. A new multireceptor somatostatin analog, SOM230 (pasireotide), as well as chimeric molecules, such as dopastatin (a combination of a somatostatin analogue plus a dopamine agonist), will come into the clinical management of GEP-NETs.

  12. Holland's Vocational Preference Inventory and the Myers-Briggs Type Indicator as Predictors of Vocational Choice among Master's of Business Administration.

    ERIC Educational Resources Information Center

    Martin, David C.; Bartol, Kathryn M.

    1986-01-01

    Tested the ability of Holland's Vocational Preference Inventory (VPI) and the Myers-Briggs Type Indicator (MBTI) to predict student business concentration. Significant discriminant analysis results were obtained for both instruments. Classification analyses supported the potential usefulness of the VPI for counseling students regarding…

  13. Concurrent Validity of Scores from an Adjectival Self-Description Checklist in Relation to Myers-Briggs Type Indicator (MBTI) Scores.

    ERIC Educational Resources Information Center

    Thompson, Bruce; Stone, Elizabeth

    The Myers-Briggs Type Indicator (MBTI) is one of the most frequently used measures of personality. MBTI Form G and a self-descriptive adjectival checklist, the "Personal Preferences Self-Description Questionnaire" (PPSDQ), were administered to 191 college students. The four dimensions of personality measured by the MBTI are:…

  14. A Comparison of the Myers-Briggs Type Indicator Extraversion-Introversion Scale, and the Minnesota Multiphasic Personality Inventory 0 Scale (Social Introversion).

    ERIC Educational Resources Information Center

    McVay, Micheal R.

    The Myers-Briggs Type Indicator (MBTI) Extraversion-Introversion scale was compared with the Minnesota Multiphasic Personality Inventory (MMPI) 0 scale (Social Introversion) for 18 male and 66 female adult students in introductory courses in psychology, aged 17 to 83 years. A status survey design was used with a priori and post hoc groupings.…

  15. Teaching Teams To Be Teams: An Exercise Using the Myers-Briggs Type Indicator and the Five-Factor Personality Traits.

    ERIC Educational Resources Information Center

    Clinebell, Sharon; Stecher, Mary

    2003-01-01

    Management students formed teams after completing exercises based on the Myers-Briggs Type Indicator and the Five-Factor Model of Personality. Team members examined how types and traits might affect performance. Most students indicated that understanding personality increased awareness of behavior. Teams that used extreme division of labor were…

  16. The Relationship between Personality Type and Software Usability Using the Myers-Briggs Type Indicator (MBTI) and the Software Usability Measurement Inventory (SUMI)

    ERIC Educational Resources Information Center

    Lindsey, William H.

    2011-01-01

    The study attempted to determine if there is a relationship between user's psychological personality types, measured by the Myers Briggs Type Indicator[R] (MBTI[R]) and distinct measures of usability measured by the Software Usability Measurement Inventory (SUMI). The study was expected to provide an answer to the following basic research…

  17. The Relationship between Personality Type and Software Usability Using the Myers-Briggs Type Indicator (MBTI) and the Software Usability Measurement Inventory (SUMI)

    ERIC Educational Resources Information Center

    Lindsey, William H.

    2011-01-01

    The study attempted to determine if there is a relationship between user's psychological personality types, measured by the Myers Briggs Type Indicator[R] (MBTI[R]) and distinct measures of usability measured by the Software Usability Measurement Inventory (SUMI). The study was expected to provide an answer to the following basic research…

  18. Teaching Teams To Be Teams: An Exercise Using the Myers-Briggs Type Indicator and the Five-Factor Personality Traits.

    ERIC Educational Resources Information Center

    Clinebell, Sharon; Stecher, Mary

    2003-01-01

    Management students formed teams after completing exercises based on the Myers-Briggs Type Indicator and the Five-Factor Model of Personality. Team members examined how types and traits might affect performance. Most students indicated that understanding personality increased awareness of behavior. Teams that used extreme division of labor were…

  19. Using the Career Orientation and Planning Profile (COPP) and the Myers-Briggs Type Indicator (MBTI) To Strengthen Adult Students' Knowledge of Self and of the Work World.

    ERIC Educational Resources Information Center

    Hayslip, Jo

    A study worked with three groups of female students to determine whether using the Career Orientation and Planning Profile (COPP) and the Myers-Briggs Type Indicator (MBTI) would enable adults to make better career choices the second time around. The students were women in the Access to Careers and Training (ACT) program for unemployed or…

  20. SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development

    PubMed Central

    Choi, Yeonsoo; Nam, Jungyong; Whitcomb, Daniel J.; Song, Yoo Sung; Kim, Doyoun; Jeon, Sangmin; Um, Ji Won; Lee, Seong-Gyu; Woo, Jooyeon; Kwon, Seok-Kyu; Li, Yan; Mah, Won; Kim, Ho Min; Ko, Jaewon; Cho, Kwangwook; Kim, Eunjoon

    2016-01-01

    Synaptogenic adhesion molecules play critical roles in synapse formation. SALM5/Lrfn5, a SALM/Lrfn family adhesion molecule implicated in autism spectrum disorders (ASDs) and schizophrenia, induces presynaptic differentiation in contacting axons, but its presynaptic ligand remains unknown. We found that SALM5 interacts with the Ig domains of LAR family receptor protein tyrosine phosphatases (LAR-RPTPs; LAR, PTPδ, and PTPσ). These interactions are strongly inhibited by the splice insert B in the Ig domain region of LAR-RPTPs, and mediate SALM5-dependent presynaptic differentiation in contacting axons. In addition, SALM5 regulates AMPA receptor-mediated synaptic transmission through mechanisms involving the interaction of postsynaptic SALM5 with presynaptic LAR-RPTPs. These results suggest that postsynaptic SALM5 promotes synapse development by trans-synaptically interacting with presynaptic LAR-RPTPs and is important for the regulation of excitatory synaptic strength. PMID:27225731

  1. Linear enamel hypoplasia in gibbons (Hylobates lar carpenteri).

    PubMed

    Guatelli-Steinberg, D

    2000-07-01

    This study describes the expression of linear enamel hypoplasia (LEH), a sensitive dental indicator of physiological stress, in Thailand gibbons (Hylobates lar carpenteri). Previous studies of enamel hypoplasia in hominoids have focused on great apes, with little attention given to the expression of this stress indicator in gibbons. In that gibbons differ from both monkeys and great apes in numerous life history features, LEH expression in gibbons might be expected to show significant differences from both. In this study, 92 gibbon specimens from two sites in Thailand were compared with several samples of monkeys and great apes in their expression of LEH. The intertooth distribution of LEH in gibbons was compared to that of chimpanzees and rhesus monkeys. Gibbon populations from both sites exhibit LEH frequencies intermediate between those of the monkey samples, in which LEH prevalence is usually low, and those of the great ape samples, in which LEH prevalence is high. Gibbons differ significantly from monkeys, but not great apes, in the number of individuals whose teeth record multiple stress events. Multiple episodes of stress are rarely recorded in the teeth of monkeys, while multiple stress events occur with higher frequency in gibbons and great apes. Taxonomic variation in the duration of crown formation, the prominence and spacing of perikymata on dental crowns, life history features, and/or experience of physiological stress may explain these patterns. The intertooth distribution of LEH in gibbons is, for different reasons, unlike that of either chimpanzees or rhesus monkeys. The mandibular canines of gibbons have significantly more LEH than any of their other teeth. Aspects of crown morphology, perikymata prominence/spacing, enamel thickness, and crown formation spans are potential causes of taxonomic variation in the intertooth distribution of LEH.

  2. The Joanna Briggs Institute Best Practice Information Sheet: the psychosocial and spiritual experiences of elderly individuals recovering from a stroke.

    PubMed

    2010-12-01

    This Best Practice Information Sheet aims to synthesize the best available evidence on the psychosocial and spiritual experiences of elderly individuals recovering from a stroke. The information that is contained in this sheet has been derived from studies that were included in a systematic review conducted by The Joanna Briggs Institute. Stroke is a major cause of death and disability and the risk of experiencing a stroke increases with age. A wide range of issues that are related to the experience of a stroke, from the perspective of the patient, have been identified in the research literature. This information sheet focuses on qualitative evidence on the short-term and long-term recovery process from the perspective of the elderly person, with the intention of assessing the evidence that would guide nursing practice.

  3. The Joanna Briggs Institute Best Practice Information Sheet: Nurse-led interventions to reduce cardiac risk factors in adults.

    PubMed

    2010-09-01

    This Best Practice Information Sheet updates and supersedes an earlier publication of the Joanna Briggs Institute in 2005. The information that is contained in this publication is based upon a systematic review of six randomized clinical trials. Additional information has been derived from a second systematic review; thus, in total, the information is derived from 22 randomized controlled trials. The original references can be sourced from the systematic reviews. Coronary heart disease (CHD) is the major cause of illness in Western society and it is becoming increasingly important to establish effective strategies in order to reduce the incidence of CHD. Nurse-led clinics are becoming more prominent in community settings and the importance of nurse interventions in the management of CHD and risk factor reduction is recognized in terms of improved health outcomes for patients. However, the variation in outcome measures and inconsistent findings between some studies make it difficult to draw firm conclusions.

  4. Similarity between partners in real and perceived personality traits as measured by the Myers-Briggs type indicator.

    PubMed

    Nordvik, H

    1996-12-01

    From 90 couples, 90 male and 90 female subjects, two sets of scores on the four personality dimensions measured by the Myers-Briggs Type Indicator (MBTI) were obtained by letting each person answer each item twice, first in the ordinary way and then as he or she believed the partner would answer the item. Correlations between partners' self-reported scores were all close to zero, whereas the correlations between the partner-reported scores and the self-reported scores were high for both males and females and for all the four dimensions measured by the MBTI, thus indicating that partners were not similar in personality traits, but they had a realistic perception of each other. The results support the hypothesis that mating is random in terms of personality traits.

  5. Treatment of autonomic neuropathy, postural tachycardia and orthostatic syncope with octreotide LAR.

    PubMed

    Hoeldtke, Robert D; Bryner, Kimberly D; Hoeldtke, Martin E; Hobbs, Gerald

    2007-12-01

    The purpose of this study was to determine whether autonomic neuropathy and the postural tachycardia syndrome can be treated with octreotide LAR (Long Acting Release). This was an open-label pilot project. Protocol 1 Patients with autonomic neuropathy (n = 4) were given increasing doses of octreotide LAR once a month for three months. Blood pressure was measured in the sitting posture every two weeks. Pretreatment mean blood pressure averaged 83.8 +/- 7.1 mm Hg. After four, six and eight weeks of therapy the blood pressures averaged 96.3 +/- 6.4, 98.2 +/- 6.1 (p < .025), and 104.1 +/- 3.1 (p < .025) respectively. Therapy led to a dramatic improvement in symptoms in one patient but another had an unacceptable elevation in supine blood pressure. Protocol 2 Patients with POTS or orthostatic intolerance were given 10, 20, or 30 mg of octreotide LAR over three months. Seven patients entered and five completed the study. After two months treatment, standing time increased from 36.0 +/- 9.2 to 59.2 +/- .8 minutes (p < .01). Heart rate in the standing position was suppressed from 106 +/- .83 to 93.2 +/- .8 beats per minute (p < .05). Orthostatic dizziness and chronic fatigue improved. We conclude that octreotide LAR can be used to treat autonomic neuropathy but there is a risk of an excessive pressor response. Octreotide LAR improved standing time and suppressed tachycardia in patients with orthostatic intolerance.

  6. Designs of Large Liquid Argon TPCs - from MicroBooNE to LBNE LAr40

    NASA Astrophysics Data System (ADS)

    Yu, B.; Makowiecki, D. S.; Mahler, G. J.; Radeka, V.; Thorn, C.; Baller, B.; Jostlein, H.; Fleming, B. T.

    Liquid argon time projection chamber (LArTPC) is a unique technology well suited for large scale detectors of neutrinos and other rare processes. Its combination of millimeter scale 3D precision particle tracking and calorimetry with good dE/dx resolution provide excellent efficiency of particle identification and background rejection. MicroBooNE is a LArTPC about to enter its final design phase and is scheduled for construction in 2012. Its active volume contains 86 ton of LAr. It has a 2.6m drift distance, 8256 sense wires connected to cold CMOS analog front-end electronics. Most of the TPC design features improve upon existing tried and true techniques. The LAr40 is one of the two far detector options under consideration for the Long Baseline Neutrino Experiment (LBNE). Its conceptual design has 40 kton active liquid argon mass, to be installed underground at a moderate depth. Due to its large scale, and underground siting, great emphasis was placed on the detector cost and reliability. A modular TPC design is the key to achieve these goals. The LAr40 consists of two 20 kton detectors in one underground cavern. Each detector is in turn constructed from an array of TPC modules. Innovative concepts enable the modules to be tiled with minimal dead space. An overview of both detectors is presented. The designs of key elements in these two TPCs are described in detail.

  7. The Liquid Argon Software Toolkit (LArSoft): Goals, Status and Plan

    SciTech Connect

    Pordes, Rush; Snider, Erica

    2016-08-17

    LArSoft is a toolkit that provides a software infrastructure and algorithms for the simulation, reconstruction and analysis of events in Liquid Argon Time Projection Chambers (LArTPCs). It is used by the ArgoNeuT, LArIAT, MicroBooNE, DUNE (including 35ton prototype and ProtoDUNE) and SBND experiments. The LArSoft collaboration provides an environment for the development, use, and sharing of code across experiments. The ultimate goal is to develop fully automatic processes for reconstruction and analysis of LArTPC events. The toolkit is based on the art framework and has a well-defined architecture to interface to other packages, including to GEANT4 and GENIE simulation software and the Pandora software development kit for pattern recognition. It is designed to facilitate and support the evolution of algorithms including their transition to new computing platforms. The development of the toolkit is driven by the scientific stakeholders involved. The core infrastructure includes standard definitions of types and constants, means to input experiment geometries as well as meta and event- data in several formats, and relevant general utilities. Examples of algorithms experiments have contributed to date are: photon-propagation; particle identification; hit finding, track finding and fitting; electromagnetic shower identification and reconstruction. We report on the status of the toolkit and plans for future work.

  8. Molecular evidence for the introgression between Hylobates lar and H. pileatus in the wild.

    PubMed

    Matsudaira, Kazunari; Reichard, Ulrich H; Malaivijitnond, Suchinda; Ishida, Takafumi

    2013-01-01

    Inter-specific hybrid zones for Hylobates gibbons are known in Southeast Asia. Among these, one hybrid zone between Hylobates lar and H. pileatus is located in Khao Yai National Park, Thailand. To find molecular evidence for the natural hybridization of the gibbons in this region, we studied mitochondrial DNA (mtDNA) of 68 gibbons of the H. lar phenotype living adjacent to the hybrid zone. Nucleotide sequencing of a fragment of mtDNA spanning hyper variable segment I showed that nine gibbons had an mtDNA haplotype of H. pileatus, and that seven of these nine gibbons belonged to a single maternal lineage over three generations. It is thus confirmed that introgression between H. lar and H. pileatus exists and the initial hybridization took place ages ago.

  9. Gastrointestinal neuroendocrine tumors treated with high dose octreotide-LAR: A systematic literature review

    PubMed Central

    Broder, Michael S; Beenhouwer, David; Strosberg, Jonathan R; Neary, Maureen P; Cherepanov, Dasha

    2015-01-01

    AIM: To review literature on efficacy and safety of octreotide-long-acting repeatable (LAR) used at doses higher than the Food and Drug Administration (FDA)-approved 30 mg/mo for treatment of neuroendocrine tumors (NETs). METHODS: We searched PubMed and Cochrane Library from 1998-2012, 5 conferences (American Society of Clinical Oncology, Endocrine Society, European Neuroendocrine Tumor Society, European Society for Medical Oncology, North American Neuroendocrine Tumor Society) from 2000-2013 using MeSH and keyterms including neuroendocrine tumors, carcinoid tumor, carcinoma, neuroendocrine, and octreotide. Bibliographies of accepted articles were also searched. Two reviewers reviewed titles, abstracts, and full-length articles. Studies that reported data on efficacy and safety of ≥ 30 mg/mo octreotide-LAR for NETs in human subjects, published in any language were included in the review. RESULTS: The search identified 1086 publications, of which 238 underwent full-text review (20 were translated into English); 17 were included in the review. Studies varied in designs, subjects, octreotide-LAR regimens, and definition of outcomes. Eleven studies reported use of higher doses to control symptoms and tumor progression, although symptom severity and formal quality-of-life analysis were not quantitatively measured. Ten studies reported efficacy, describing 260 subjects with doses ranging from 40 mg/mo or 30 mg/3 wk up to 120 mg/mo. Eight studies reported expert clinical opinion that supported dose escalation of octreotide-LAR up to 60 mg/mo for symptom control and suggested increased doses may be effective at preventing tumor progression. Eight studies reported safety; there was no evidence of increased toxicity associated with doses of octreotide-LAR > 30 mg/mo. CONCLUSION: As reported in this review, octreotide-LAR at doses > 30 mg/mo is being prescribed for symptom and tumor control in NET patients. Furthermore, expert clinical opinion provided support for

  10. Peology and Geochemistry of New Paired Martian Meteorites 12095 and LAR 12240

    NASA Technical Reports Server (NTRS)

    Funk, R. C.; Brandon, A. D.; Peslier, A.

    2015-01-01

    The meteorites LAR 12095 and LAR 12240 are believed to be paired Martian meteorites and were discovered during the Antarctic Search for Meteorites (ANSMET) 2012-2013 Season at Larkman Nunatak. The purpose of this study is to characterize these olivine-phyric shergottites by analyzing all mineral phases for major, minor and trace elements and examining their textural relationships. The goal is to constrain their crystallization history and place these shergottites among other Martian meteorites in order to better understand Martian geological history.

  11. LArGe: Background suppression using liquid argon (LAr) scintillation for 0 νββ decay search with enriched germanium (Ge) detectors

    NASA Astrophysics Data System (ADS)

    Di Marco, M.; Peiffer, P.; Schönert, S.

    2007-10-01

    Measurements with a bare p-type high purity germanium diode (HPGe) submerged in a 19 kg liquid argon (LAr) scintillation detector at MPIK-Heidelberg are reported. The liquid argon-germanium system (LArGe) is operated as a 4 π anti-Compton spectrometer to suppress backgrounds in the HPGe. This R&D is carried out in the framework of the Gerda experiment which searches for 0 νββ decays with HPGe detectors enriched in 76Ge. The goal of this work is to develop a novel method to discriminate backgrounds in 0 νββ search which would ultimately allow to investigate the effective neutrino mass free of background events down to the inverse mass hierarchy scale. Other applications in low-background counting are expected.

  12. The Role of the Myers-Briggs Personality Type and Emotional Intelligence in Marital Satisfaction among Married Female Students at Tehran University.

    PubMed

    Shirzad, Galin

    2016-10-01

    The present descriptive correlational study was conducted to predict the role of emotional intelligence and the Myers-Briggs personality type in marital satisfaction in married female students Tehran University in 2015. The study population consisted of all the married female students at Tehran University who visited Iran MBTI center between 22.04.2015 and 21.06.2015. A total of 140 students were selected as the study samples. Data were collected using the Myer-Briggs Type Indicator, the Bar-On Emotional Intelligence Questionnaire and the Enrich Marital Satisfaction Scale and were then analyzed in SPSS-20 using the multivariate regression analysis. The results obtained showed that emotional intelligence (interpersonal and intra-personal skills) and personality type (extraverted and structured) can predict marital satisfaction.

  13. Regulation of Platelet Derived Growth Factor Signaling by Leukocyte Common Antigen-related (LAR) Protein Tyrosine Phosphatase: A Quantitative Phosphoproteomics Study*

    PubMed Central

    Tomlinson, Michael G.; Hellberg, Carina; Hotchin, Neil A.

    2016-01-01

    Intracellular signaling pathways are reliant on protein phosphorylation events that are controlled by a balance of kinase and phosphatase activity. Although kinases have been extensively studied, the role of phosphatases in controlling specific cell signaling pathways has been less so. Leukocyte common antigen-related protein (LAR) is a member of the LAR subfamily of receptor-like protein tyrosine phosphatases (RPTPs). LAR is known to regulate the activity of a number of receptor tyrosine kinases, including platelet-derived growth factor receptor (PDGFR). To gain insight into the signaling pathways regulated by LAR, including those that are PDGF-dependent, we have carried out the first systematic analysis of LAR-regulated signal transduction using SILAC-based quantitative proteomic and phosphoproteomic techniques. We haveanalyzed differential phosphorylation between wild-type mouse embryo fibroblasts (MEFs) and MEFs in which the LAR cytoplasmic phosphatase domains had been deleted (LARΔP), and found a significant change in abundance of phosphorylation on 270 phosphosites from 205 proteins because of the absence of the phosphatase domains of LAR. Further investigation of specific LAR-dependent phosphorylation sites and enriched biological processes reveal that LAR phosphatase activity impacts on a variety of cellular processes, most notably regulation of the actin cytoskeleton. Analysis of putative upstream kinases that may play an intermediary role between LAR and the identified LAR-dependent phosphorylation events has revealed a role for LAR in regulating mTOR and JNK signaling. PMID:27074791

  14. LAR receptor tyrosine phosphatases and HSPGs guide peripheral sensory axons to the skin

    PubMed Central

    Wang, Fang; Wolfson, Sean N.; Gharib, Arash; Sagasti, Alvaro

    2012-01-01

    Background Peripheral axons of somatosensory neurons innervate the skin early in development to detect touch stimuli. Embryological experiments had suggested that the skin produces guidance cues that attract sensory axons, but neither the attractants nor their neuronal receptors had previously been identified. Results To investigate peripheral axon navigation to the skin, we combined live imaging of developing zebrafish Rohon-Beard (RB) neurons with molecular loss-of-function manipulations. Simultaneously knocking down two members of the LAR family of receptor tyrosine phosphatases expressed in RB neurons, or inhibiting their function with dominant negative proteins, misrouted peripheral axons to internal tissues. Time-lapse imaging indicated that peripheral axon guidance, rather than outgrowth or maintenance, was defective in LAR deficient neurons. Peripheral axons displayed a similar misrouting phenotype in mutants defective in heparan sulfate proteoglycan (HSPG) production and avoided regions in which HSPGs were locally degraded. Conclusions HSPGs and LAR family receptors are required for sensory axon guidance to the skin. Together, our results support a model in which peripheral HSPGs are attractive ligands for LAR receptors on RB neurons. PMID:22326027

  15. SER-LARS, Volume 4. Learning Objective History III. 1975-76 Edition.

    ERIC Educational Resources Information Center

    Montgomery County Intermediate Unit 23, Blue Bell, PA.

    The fourth volume in the SER-LARS (Special Education Resources Location Analysis and Retrieval System) series, a diagnostic-prescriptive instructional data bank for teachers of handicapped children, presents a continuation of learning objectives organized by content descriptions. Entrees give a history of the use of each objective along with…

  16. Electron lifetime measurement using cosmic ray muons at the MicroBooNE LArTPC

    NASA Astrophysics Data System (ADS)

    Meddage, Varuna Crishan; MicroBooNE Collaboration

    2017-01-01

    MicroBooNE, a 170 ton liquid argon time projection chamber (LArTPC) located on the Fermilab's Booster Neutrino Beamline (BNB), is designed to both probe neutrino physics phenomena and further develop the LArTPC detector technology. MicroBooNE is the largest currently operating LArTPC detector and began collecting data in Fall 2015. LArTPCs are imaging detectors that offer exceptional capabilities for studying neutrinos. A fundamental requirement for the performance of such detectors is to maintain electronegative contaminants such as oxygen and water at extremely low concentrations, which otherwise can absorb the ionization electrons. The impurity levels in liquid argon can be estimated from the drift electron lifetime as they are inversely proportional to each other. This talk presents a measurement of the drift electron lifetime using cosmic ray muon data collected by MicroBooNE. An interpretation of the observed drift electron lifetime as a function of time indicates that the electron attenuation due to impurities in the liquid argon is negligible during normal operations, implying that the argon purification and gas recirculation system in MicroBooNE is performing successfully.

  17. SER-LARS, Volume 3. Learning Objective History II. 1975-76 Edition.

    ERIC Educational Resources Information Center

    Montgomery County Intermediate Unit 23, Blue Bell, PA.

    The third of nine volumes in the SER-LARS (Special Education Resources Location Analysis and Retrieval System) series, a diagnostic-prescriptive instructional data bank for teachers of handicapped children, presents learning objectives organized by content descriptions. Entries give a history of the use of each objective along with information on…

  18. SER-LARS, Volume 6. Instructional Materials, Teacher Made and Commercially Adapted. 1975-76 Edition.

    ERIC Educational Resources Information Center

    Montgomery County Intermediate Unit 23, Blue Bell, PA.

    The sixth of nine volumes in the Special Education Resources Location Analysis and Retrieval System (SER-LARS), a diagnostic-prescriptive instructional data bank for teachers of handicapped children, presents an inventory of teacher-made and commercially adapted instructional materials. The instructional materials are organized by accession number…

  19. SER-LARS, Volume 10. Instructional Methods I. 1975-76 Edition.

    ERIC Educational Resources Information Center

    Montgomery County Intermediate Unit 23, Blue Bell, PA.

    The book briefly describes several hundred instructional methods from the Special Education Resources Location Analysis and Retrieval System (SER-LARS), which are intended for use in developing and carrying out individualized programs for handicapped children. Each teaching method includes an accession number; title; author; source; teacher tasks;…

  20. SER-LARS, Volume 12. Instructional Methods III. 1975-76 Edition.

    ERIC Educational Resources Information Center

    Montgomery County Intermediate Unit 23, Blue Bell, PA.

    The book briefly describes several hundred instructional methods from the Special Education Resources Location Analysis and Retrieval System (SER-LARS), which are intended for use in developing and carrying out individualized programs for handicapped children. Each teaching method includes an accession number; title; author; source; teacher tasks;…

  1. SER-LARS, Volume 11. Instructional Methods II. 1975-76 Edition.

    ERIC Educational Resources Information Center

    Montgomery County Intermediate Unit 23, Blue Bell, PA.

    The book briefly describes several hundred instructional methods from the Special Education Resources Location Analysis and Retrieval System (SER LARS), which are intended for use in developing and carrying out individualized programs for handicapped children. Each teaching method includes an accession number; title; author; source; teacher tasks;…

  2. LAr calorimeter for SCC with a common vacuum bulkhead---a concept to improve hermeticity

    SciTech Connect

    Pope, W.L. ); Watt, R.D. )

    1989-11-01

    A new concept for a Barrel/Endcap LAr Calorimeter (LAC) is described in which the Barrel and Endcaps are in separate vacuum enclosures but share a common vacuum bulkhead (CVB). We explore 2 possible bulkhead construction types; welded plate sandwich panels, and brazed sandwich panels in which the core is an isotropic cellular solid--foamed aluminum. Gas lines and electric cables from he innermost Drift Chamber pass through radial holes in the core of the sandwich bulkhead. The CVB concept offers the potential to obtain a more hermetic calorimeter with significantly reduced dead material and/or space in the interface region common to conventional design LAr detectors for the SSC with Endcap features. To utilize a common additional steps to remove the Drift Chamber, a large increase in Endcap standby heat leak, and perhaps, new cryogenic safety issues. We find that significant amount of dead mass can be removed from critical regions of the vacuum shells when compared to a promising SSC LAC reference design. It is also shown that the increased standby heat leak of this concept can be easily removed by existing cooling capacity in another large LAr calorimeter. It is further shown that shut-downs need not be appreciably longer. Finally, it is argued that cryogen spill hazards can be avoided if the Endcap's LAr is removed during Drift chamber maintenance shutdowns, and that cryogenic safety is not compromised.

  3. Physician personality types in physical medicine and rehabilitation as measured by the Myers-Briggs Type Indicator.

    PubMed

    Sliwa, J A; Shade-Zeldow, Y

    1994-01-01

    Personality is one variable that correlates with specialty selection and practice type. To test our hypothesis that there has been a change in the personality type of those entering Physical Medicine and Rehabilitation (PM&R) and to identify the academic potential of those in rehabilitation, we invited all residents and graduates of our training program to participate in a study of personality types within PM&R by completing a Myers-Briggs Type Indicator (MBTI). Thirty residents and 48 graduates completed the questionnaire. A wide range of personality types were represented in our sample. The most common types are shared by a number of other people-oriented, primary care specialties. There was a statistically significant difference between residents and graduates on two of the four MBTI indexes, with graduates more introverted (P < 0.05) and judging (P < 0.001) than the present residents. Intuition, previously correlated with research and academic practice, was the dominant process for the majority of graduates and residents. This would confirm, according to type theory, the academic potential of both graduates and residents in our training program.

  4. Reinterpreting the Myers-Briggs Type Indicator from the perspective of the five-factor model of personality.

    PubMed

    McCrae, R R; Costa, P T

    1989-03-01

    The Myers-Briggs Type Indicator (MBTI; Myers & McCaulley, 1985) was evaluated from the perspectives of Jung's theory of psychological types and the five-factor model of personality as measured by self-reports and peer ratings on the NEO Personality Inventory (NEO-PI; Costa & McCrae, 1985b). Data were provided by 267 men and 201 women ages 19 to 93. Consistent with earlier research and evaluations, there was no support for the view that the MBTI measures truly dichotomous preferences or qualitatively distinct types; instead, the instrument measures four relatively independent dimensions. The interpretation of the Judging-Perceiving index was also called into question. The data suggest that Jung's theory is either incorrect or inadequately operationalized by the MBTI and cannot provide a sound basis for interpreting it. However, correlational analyses showed that the four MBTI indices did measure aspects of four of the five major dimensions of normal personality. The five-factor model provides an alternative basis for interpreting MBTI findings within a broader, more commonly shared conceptual framework.

  5. Budget impact of pasireotide LAR for the treatment of acromegaly, a rare endocrine disorder.

    PubMed

    Zhang, J J; Nellesen, D; Ludlam, W H; Neary, M P

    2016-01-01

    Acromegaly is a rare disorder characterized by the over-production of growth hormone (GH). Patients often experience a range of chronic comorbidities including hypertension, cardiac dysfunction, diabetes, osteoarthropathy, and obstructive sleep apnea. Untreated or inadequately controlled patients incur substantial healthcare costs, while normalization of GH levels may reduce morbidity and mortality rates to be comparable to the general population. To assess the 3-year budget impact of pasireotide LAR on a US managed care health plan following pasireotide LAR availability. Two separate economic models were developed: one from the perspective of an entire health plan and another from the perspective of a pharmacy budget. The total budget impact model includes costs of drug therapies and other costs for treatment, monitoring, management of adverse events, and comorbidities. The pharmacy cost calculator only considers drug costs. The total estimated budget impact associated with the introduction of pasireotide LAR is 0.31 cents ($0.0031) per member per month (PMPM) in the first year, 0.78 cents ($0.0078) in the second year, and 1.42 cents ($0.0142) in the third year following FDA approval. Costs were similar or lower from a pharmacy budget impact perspective. For each patient achieving disease control, cost savings from reduced comorbidities amounted to $10,240 per year. Published data on comorbidities for acromegaly are limited. In the absence of data on acromegaly-related costs for some comorbidities, comorbidity costs for the general population were used (may be under-estimates). The budget impact of pasireotide LAR is expected to be modest, with an expected increase of 1.42 cents PMPM on the total health plan budget in the third year after FDA approval. The efficacy of pasireotide LAR in acromegaly, as demonstrated in head-to-head trials compared with currently available treatment options, is expected to be associated with a reduction of the prevalence of

  6. Phase II study of monthly pasireotide LAR (SOM230C) for recurrent or progressive meningioma

    PubMed Central

    Norden, Andrew D.; Ligon, Keith L.; Hammond, Samantha N.; Muzikansky, Alona; Reardon, David A.; Kaley, Thomas J.; Batchelor, Tracy T.; Plotkin, Scott R.; Raizer, Jeffrey J.; Wong, Eric T.; Drappatz, Jan; Lesser, Glenn J.; Haidar, Sam; Beroukhim, Rameen; Lee, Eudocia Q.; Doherty, Lisa; Lafrankie, Debra; Gaffey, Sarah C.; Gerard, Mary; Smith, Katrina H.; McCluskey, Christine; Phuphanich, Surasak

    2015-01-01

    Objective: A subset of meningiomas recur after surgery and radiation therapy, but no medical therapy for recurrent meningioma has proven effective. Methods: Pasireotide LAR is a long-acting somatostatin analog that may inhibit meningioma growth. This was a phase II trial in patients with histologically confirmed recurrent or progressive meningioma designed to evaluate whether pasireotide LAR prolongs progression-free survival at 6 months (PFS6). Patients were stratified by histology (atypical [World Health Organization grade 2] and malignant [grade 3] meningiomas in cohort A and benign [grade 3] in cohort B). Results: Eighteen patients were accrued in cohort A and 16 in cohort B. Cohort A had median age 59 years, median Karnofsky performance status 80, 17 (94%) had previous radiation therapy, and 11 (61%) showed high octreotide uptake. Cohort B had median age 52 years, median Karnofsky performance status 90, 11 (69%) had previous radiation therapy, and 12 (75%) showed high octreotide uptake. There were no radiographic responses to pasireotide LAR therapy in either cohort. Twelve patients (67%) in cohort A and 13 (81%) in cohort B achieved stable disease. In cohort A, PFS6 was 17% and median PFS 15 weeks (95% confidence interval: 8–20). In cohort B, PFS6 was 50% and median PFS 26 weeks (12–43). Treatment was well tolerated. Octreotide uptake and insulin-like growth factor–1 levels did not predict outcome. Expression of somatostatin receptor 3 predicted favorable PFS and overall survival. Conclusions: Pasireotide LAR has limited activity in recurrent meningiomas. The finding that somatostatin receptor 3 is associated with favorable outcomes warrants further investigation. Classification of evidence: This study provides Class IV evidence that in patients with recurrent or progressive meningioma, pasireotide LAR does not significantly increase the proportion of patients with PFS at 6 months. PMID:25527270

  7. Inactivation of LAR family phosphatase genes Ptprs and Ptprf causes craniofacial malformations resembling Pierre-Robin sequence.

    PubMed

    Stewart, Katherine; Uetani, Noriko; Hendriks, Wiljan; Tremblay, Michel L; Bouchard, Maxime

    2013-08-01

    Leukocyte antigen related (LAR) family receptor protein tyrosine phosphatases (RPTPs) regulate the fine balance between tyrosine phosphorylation and dephosphorylation that is crucial for cell signaling during development and tissue homeostasis. Here we show that LAR RPTPs are required for normal development of the mandibular and maxillary regions. Approximately half of the mouse embryos lacking both Ptprs (RPTPσ) and Ptprf (LAR) exhibit micrognathia (small lower jaw), cleft palate and microglossia/glossoptosis (small and deep tongue), a phenotype closely resembling Pierre-Robin sequence in humans. We show that jaw bone and cartilage patterning occurs aberrantly in LAR family phosphatase-deficient embryos and that the mandibular arch harbors a marked decrease in cell proliferation. Analysis of signal transduction in embryonic tissues and mouse embryonic fibroblast cultures identifies an increase in Bmp-Smad signaling and an abrogation of canonical Wnt signaling associated with loss of the LAR family phosphatases. A reactivation of β-catenin signaling by chemical inhibition of GSK3β successfully resensitizes LAR family phosphatase-deficient cells to Wnt induction, indicating that RPTPs are necessary for normal Wnt/β-catenin pathway activation. Together these results identify LAR RPTPs as important regulators of craniofacial morphogenesis and provide insight into the etiology of Pierre-Robin sequence.

  8. The Laminin–Nidogen Complex is a Ligand for a Specific Splice Isoform of the Transmembrane Protein Tyrosine Phosphatase LAR

    PubMed Central

    O'Grady, Pauline; Thai, Tran Cam; Saito, Haruo

    1998-01-01

    Leukocyte antigen–related protein (LAR) is a prototype for a family of transmembrane protein tyrosine phosphatases whose extracellular domain is composed of three Ig and several fibronectin type III (FnIII) domains. Complex alternative splicing of the LAR-FnIII domains 4–8 has been observed. The extracellular matrix laminin–nidogen complex was identified as a ligand for the LAR-FnIII domain 5 (Fn5) using a series of GST-LAR-FnIII domain fusion proteins and testing them in in vitro ligand-binding assays. LAR– laminin–nidogen binding was regulated by alternative splicing of a small exon within the LAR-Fn5 so that inclusion of this exon sequence resulted in disruption of the laminin–nidogen-binding activity. Long cellular processes were observed when HeLa cells were plated on laminin–nidogen, but not when plated on a fibronectin surface. Indirect immunofluorescent antibody staining revealed high expression of LAR in a punctate pattern, throughout the length of these cellular processes observed on laminin–nidogen. Antibody-induced cross-linking of LAR inhibited formation of these cellular processes, and inhibition was correlated with changes in cellular actin cytoskeletal structure. Thus, LAR–laminin–nidogen binding may play a role in regulating cell signaling induced by laminin–nidogen, resulting in cell morphological changes. PMID:9647658

  9. Anterior cruciate ligament repair with LARS (ligament advanced reinforcement system): a systematic review

    PubMed Central

    2010-01-01

    Background Injury to the anterior cruciate ligament (ACL) of the knee is common. Following complete rupture of the ACL, insufficient re-vascularization of the ligament prevents it from healing completely, creating a need for reconstruction. A variety of grafts are available for use in ACL reconstruction surgery, including synthetic grafts. Over the last two decades new types of synthetic ligaments have been developed. One of these synthetic ligaments, the Ligament Advanced Reinforcement System (LARS), has recently gained popularity. The aim of this systematic review was to assess the current best available evidence for the effectiveness of the LARS as a surgical option for symptomatic, anterior cruciate ligament rupture in terms of graft stability, rehabilitation time and return to pre-injury function. Method This systematic review included studies using subjects with symptomatic, ACL ruptures undergoing LARS reconstruction. A range of electronic databases were searched in May 2010. The methodological quality of studies was appraised with a modified version of the Law critical appraisal tool. Data relating to study characteristics, surgical times, complication rates, outcomes related to knee stability, quality of life, function, and return to sport as well as details of rehabilitation programs and timeframes were collected. Results This review identified four studies of various designs, of a moderate methodological quality. Only one case of knee synovitis was reported. Patient satisfaction with LARS was high. Graft stability outcomes were found to be inconsistent both at post operative and at follow up periods. The time frames of rehabilitation periods were poorly reported and at times omitted. Return to pre-injury function and activity was often discussed but not reported in results. Conclusions There is an emerging body of evidence for LARS with comparable complication rates to traditional surgical techniques, and high patient satisfaction scores. However, this

  10. Integrated plan for LArTPC neutrino detectors in the US

    SciTech Connect

    Baller, B.; Fleming, B.; /Fermilab

    2009-11-01

    We present an integrated R&D plan aimed at demonstrating the ability to build a very large Liquid Argon Time Projection Chamber (LArTPC), on a scale suitable for use as a Far Detector for the LBNE neutrino oscillation experiment. This plan adopts current LArTPC R&D-related activities and proposes new ones to address questions that go beyond those being answered by the current efforts. We have employed a risk evaluation strategy to identify questions that can be answered (or risks that can be mitigated) through one or more R&D steps. In summary form, the plan consists of the following pre-existing components: (1) The Materials Test Stand program, now in operation at Fermilab, addressing questions pertaining to maintenance of argon purity; (2) Existing electronics test stands at FNAL and BNL; (3) The Liquid Argon Purity Demonstrator (LAPD) now being assembled at Fermilab; (4) The ArgoNeuT prototype LArTPC, now running in the NuMI beam; (5) The MicroBooNE experiment, proposed as a physics experiment that will advance our understanding of the LArTPC technology, now completing its conceptual design phase; (6) A software development effort that is well integrated across present and planned LArTPC detectors. We are proposing to add to these efforts the following: (1) A membrane cryostat mechanical prototype to evaluate and gain expertise with this technology; (2) An installation and integration prototype, to understand issues pertaining to detector assembly, particularly in an underground environment; (3) A {approx} 5% scale electronics systems test to understand system-wide issues as well as individual component reliability. (4) A calibration test stand that would consist of a small TPC to be exposed to a test beam for calibration studies, relevant for evaluation of physics sensitivities. We have developed a timeline and milestones for achieving these goals as discussed in Section 4. The proposed activities necessary for the final design of LAr20 are complete by CD3 in

  11. Relationship between DHI production values and Myers-Briggs type indicator as a measure of management ability.

    PubMed

    Young, A J; Walters, J L

    2002-08-01

    Associations between owners' Myers-Briggs Type Indicator (MBTI) preferences (E = extraversion vs. I = introversion; S = sensing vs. N = intuition; T = thinking vs F = feeling; J = judging vs. P = perceiving) and 21 Dairy Herd Improvement (DHI) production variables were determined on 60 farms. Of 60 dairy farmers participating, 51 were from Holstein farms (85%) and nine from farms with other breeds, primarily Jersey. Cows were milked either twice (n = 44 herds, 73%) or three times (n = 16) per day. Farmers were evenly split between the "E" and "I" dimension, whereas 93% of the farmers were "S," 75% "T," and 62% "J.". Individuals with a preference for the "I" dimension were associated with higher peak and mature equivalent milk yield than those individuals with a preference for the "E" dimension. The "T" and "J" dimensions had a significantly higher percentage of the herd with records usable by USDA and a lower percentage of animals pregnant by the goal set by the dairy producer than the "F" and "P" dimensions. Herds managed by individuals with a combination preference of "E" and "P" produced 7 to 10 kg of 3.5% FCM/cow per day less or 1,820 to 2,752 kg/ cow RHA ECM less than other combinations of the "E-I" and "J-P" dimensions. Those herds also had longer days dry and a lower percentage of records usable by USDA, suggesting that the "E-P" preference is less favorably associated to those measures of herd performance. The MBTI had limited association with many DHI production variables, but relationships to measures of labor and business management should be examined.

  12. Michel Electron Reconstruction Using the MicroBooNE LArTPC Cosmic Data

    NASA Astrophysics Data System (ADS)

    Caratelli, David; MicroBooNE Collaboration

    2017-09-01

    MicroBooNE is a Liquid Argon Time Projection Chamber (LArTPC) neutrino detector located in the Booster Neutrino Beamline at Fermilab which began collecting neutrino data in October 2015. MicroBooNE aims to explore the low energy excess in the ν e spectrum reported by MiniBooNE as well as perform ν-Ar cross-section measurements. In this note, we present the current status of reconstructing Michel electrons from cosmic ray muons in the MicroBooNE detector. These electrons are distributed uniformly inside the detector, and serve as a natural and powerful sample to study the detector’s response for low energy (tens of MeV) interactions as a function of position. We have developed a reconstruction software tool to identify such Michel electrons which could be of benefit to LArTPC experiments generically.

  13. A most distant intergeneric hybrid offspring (Larcon) of lesser apes, Nomascus leucogenys and Hylobates lar.

    PubMed

    Hirai, Hirohisa; Hirai, Yuriko; Domae, Hiroshi; Kirihara, Yoko

    2007-12-01

    Unlike humans, which are the sole remaining representatives of a once larger group of bipedal apes (hominins), the "lesser apes" (hylobatids) are a diverse radiation with numerous extant species. Consequently, the lesser apes can provide a valuable evolutionary window onto the possible interactions (e.g., interbreeding) of hominin lineages coexisting in the same time and place. In the present work, we employ chromosomal analyses to verify the hybrid ancestry of an individual (Larcon) produced by two of the most distant genera of lesser apes, Hylobates (lar-group gibbons) and Nomascus (concolor-group gibbons). In addition to a mixed pelage pattern, the hybrid animal carries a 48-chromosome karyotype that consists of the haploid complements of each parental species: Hylobates lar (n = 22) and Nomascus leucogenys leucogenys (n = 26). Studies of this animal's karyotype shed light onto the processes of speciation and genus-level divergence in the lesser apes and, by extension, across the Hominoidea.

  14. Light-Based Triggering and Reconstruction of Michel Electrons in LArIAT

    SciTech Connect

    Foreman, W.

    2016-01-19

    The LArIAT Experiment aims to calibrate the liquid argon time projection chamber (LArTPC) using a beam of charged particles at the Fermilab Test Beam Facility. It is equipped with a novel scintillation light readout system using PMTs and custom SiPM preamplifier boards to detect light from reflector foils coated with wavelength-shifting TPB. A trigger on delayed secondary flashes of light captures events containing stopping cosmic muons together with the Michel electrons coming from their subsequent decay. This dedicated Michel trigger supplies an abundant sample of low-energy electrons throughout the detector's active volume, providing opportunities to study the combined calorimetric capabilities of the light system and the TPC. Preliminary results using scintillation light to study properties of the Michel electron sample are presented.

  15. Soft error rate estimations of the Kintex-7 FPGA within the ATLAS Liquid Argon (LAr) Calorimeter

    NASA Astrophysics Data System (ADS)

    Wirthlin, M. J.; Takai, H.; Harding, A.

    2014-01-01

    This paper summarizes the radiation testing performed on the Xilinx Kintex-7 FPGA in an effort to determine if the Kintex-7 can be used within the ATLAS Liquid Argon (LAr) Calorimeter. The Kintex-7 device was tested with wide-spectrum neutrons, protons, heavy-ions, and mixed high-energy hadron environments. The results of these tests were used to estimate the configuration ram and block ram upset rate within the ATLAS LAr. These estimations suggest that the configuration memory will upset at a rate of 1.1 × 10-10 upsets/bit/s and the bram memory will upset at a rate of 9.06 × 10-11 upsets/bit/s. For the Kintex 7K325 device, this translates to 6.85 × 10-3 upsets/device/s for configuration memory and 1.49 × 10-3 for block memory.

  16. Selective expression of CSPG receptors PTPσ and LAR in poorly regenerating reticulospinal neurons of lamprey.

    PubMed

    Zhang, Guixin; Hu, Jianli; Li, Shuxin; Huang, Lisa; Selzer, Michael E

    2014-06-15

    Disability following spinal cord injury is due to failure of axon regeneration, which has been ascribed to environmental factors in the central nervous system and a developmental loss of intrinsic growth capacity in neurons. Recently, the receptor-like protein tyrosine phosphatases, protein tyrosine phosphatase σ (PTPσ) and leukocyte common antigen-related phosphatase (LAR), have been identified as specific receptors for the regeneration-inhibiting matrix molecules chondroitin sulfate proteoglycans (CSPGs). After spinal cord transection in lampreys, axons of the large, identified reticulospinal neurons have heterogeneous regenerative abilities. The bad-regenerating neurons also undergo a delayed form of axotomy-induced apoptosis. In the present study, a lamprey genomic database was used to identify homologs of CSPGs, clone PTPσ and LAR, and examine their mRNA expression. CSPG immunoreactivity was increased significantly near the lesion at 2 weeks post transection, and decreased thereafter. Both receptors were expressed selectively in the bad-regenerating neurons and had overlapping cellular distributions. PTPσ was upregulated with age (LAR was not evaluated). By 2 weeks post transection, neurons expressing PTPσ also showed caspase activation, suggesting apoptosis. The probability of axon regeneration for individual identified neurons was negatively correlated with the expression level of PTPσ in both control and spinal cord-transected lampreys. In an animal 7 weeks post transection, regenerated axons were labeled retrogradely from beyond the transection. PTPσ expression and caspase labeling was seen only in neurons whose axon had not regenerated. These results are consistent with a possible role for PTPσ (and LAR) in both retrograde neuronal death and the poor intrinsic regenerative ability of bad-regenerating neurons.

  17. Application of SDSM and LARS-WG for simulating and downscaling of rainfall and temperature

    NASA Astrophysics Data System (ADS)

    Hassan, Zulkarnain; Shamsudin, Supiah; Harun, Sobri

    2014-04-01

    Climate change is believed to have significant impacts on the water basin and region, such as in a runoff and hydrological system. However, impact studies on the water basin and region are difficult, since general circulation models (GCMs), which are widely used to simulate future climate scenarios, do not provide reliable hours of daily series rainfall and temperature for hydrological modeling. There is a technique named as "downscaling techniques", which can derive reliable hour of daily series rainfall and temperature due to climate scenarios from the GCMs output. In this study, statistical downscaling models are used to generate the possible future values of local meteorological variables such as rainfall and temperature in the selected stations in Peninsular of Malaysia. The models are: (1) statistical downscaling model (SDSM) that utilized the regression models and stochastic weather generators and (2) Long Ashton research station weather generator (LARS-WG) that only utilized the stochastic weather generators. The LARS-WG and SDSM models obviously are feasible methods to be used as tools in quantifying effects of climate change condition in a local scale. SDSM yields a better performance compared to LARS-WG, except SDSM is slightly underestimated for the wet and dry spell lengths. Although both models do not provide identical results, the time series generated by both methods indicate a general increasing trend in the mean daily temperature values. Meanwhile, the trend of the daily rainfall is not similar to each other, with SDSM giving a relatively higher change of annual rainfall compared to LARS-WG.

  18. Cerebral infarction and myocardial fibrosis in a white-handed gibbon (Hylobates lar).

    PubMed

    Borkowski, R; Taylor, T G; Rush, J

    2000-03-01

    A white-handed gibbon (Hylobates lar) lost the use of its right hand. Complete blood count, serum chemistry profile, electrocardiographic findings, blood pressure, and radiographic work-up were normal, but the gibbon died 2 days later. The gibbon was serologically positive for herpes simplex I and Epstein-Barr virus. Necropsy and histopathology showed acute infarction of the right cerebrum and multifocal to coalescing severe myocardial fibrosis.

  19. Wire-Cell Tomographic Event Reconstruction for large LArTPCs

    NASA Astrophysics Data System (ADS)

    Qian, Xin; Viren, Brett; Zhang, Chao; Wire-Cell Team

    2016-03-01

    Event reconstruction is one of the most challenging tasks in analyzing the data from current and future large liquid argon time projection chambers (LArTPCs). The performance of the event reconstruction holds the key to many potential future discoveries with the LArTPC technology including i) searching for new CP violation in the leptonic sector, ii) determining the neutrino mass hierarchy, and iii) searching for additional light (sterile) neutrino species. In this talk, we introduce a new reconstruction method: Wire-Cell. The principle of Wire-Cell strictly follows the principle of LArTPC, that is, the same amount of ionization electrons are observed by all the wire-planes. Using both time and charge information, 3D image of the event topologies are firstly obtained. Further reconstruction steps including the clustering, tracking, and particle identifications (PID) are then directly applied to the 3D image. The principle, current status, and future development plan of Wire-Cell will be described. The results of Wire-Cell event reconstruction will be shown with an innovative web-based ``BEE'' 3D event display. This work is supported by U.S. Department of Energy, Office of Science, Office of High Energy Physics and Early Career Research program under Contract Number DE-SC0012704.

  20. Upgraded Trigger Readout Electronics for the ATLAS LAr Calorimeters for Future LHC Running

    NASA Astrophysics Data System (ADS)

    Ma, Hong; ATLAS Liquid Argon Calorimeter Group

    2015-02-01

    The ATLAS Liquid Argon (LAr) calorimeters produce almost 200K signals that are digitized and processed by the front-end and back-end electronics for every triggered event. Additionally, the front-end electronics sums analog signals to provide coarse-grained energy sums to the first- level (L1) trigger system. The current design was optimized for the nominal LHC luminosity of 1034cm-2s-1. In order to retain the capability to trigger on low energy electrons and photons when the LHC is upgraded to higher luminosity, an improved LAr calorimeter trigger readout is proposed and being constructed. The new trigger readout system makes available the fine segmentation of the calorimeter at the L1 trigger with high precision in order to reduce the QCD jet background in electron, photon and tau triggers, and to improve jet and missing ET trigger performance. The new LAr Trigger Digitizer Board is designed to receive the higher granularity signals, digitize them on-detector and send them via fast optical links to a new Digital Processing System. The reconstructed energies of trigger readout channels after digital filtering are transmitted to the L1 system, allowing the extraction of improved trigger signatures. This contribution presents the motivation for the upgrade, the concept for the new trigger readout and the expected performance of the new trigger, and describes the components being developed for the new system.

  1. A comparison of music education and music therapy majors: personality types as described by the Myers-Briggs Type Indicator and demographic profiles.

    PubMed

    Steele, Anita Louise; Young, Sylvester

    2008-01-01

    The purpose of this study was to develop both personality and demographic profiles for students who are interested in majoring in music education or music therapy. Two primary questions were addressed in the study: (a) Are there similarities and differences in the personality types of music education and music therapy majors as measured by the Myers Briggs Type Indicator (MBTI )? (b) Are there similarities and differences in demographic characteristics of music education and music therapy majors in regard to (i) principal instrument studied in college, (ii) grade point average, (iii) scholarship awards, (iv) high school participation in private study and (v) ensembles, (vi) church/community participation, and (vii) volunteerism in high school?

  2. University studies science course selection and academic achievement in relation to the Myers-Briggs Type Indicator

    NASA Astrophysics Data System (ADS)

    Skauge, Suzanne Elizabeth

    This research conducted at a southern regional university studied general education (University Studies - US) science course selection and academic success in US science in relation to Myers-Briggs Type Indicator (MBTI) preference categories (SF, ST, NF and NT). Additionally, differences in type preferences among students with mathematics and/or reading competency were explored. Data was examined for 755 students enrolled in the freshman success seminar course between Fall 1989 and Spring 1995 who had completed the MBTI test as part of that class. US science courses examined were grouped by science study: earth science, biology, chemistry and physics. Academic success was defined as a grade of "C" or higher and proficiency criteria were dictated by the university catalog. The study's nonparametric test results did not find any significant differences between MBTI type preferences and the two main areas of focus, US science course selection and academic success in US science courses. However, significant proportional differences were found between type preferences in relation to student reading competency (sig. = .03), as well as, reading competency and academic success in science (sig. = .04) even though fairly weak relationships existed between the variables with contingency coefficients of .11 and .10 respectively. All other relationships tested proved not significant. Each type's course selection closely reflected the overall sample: Earth Science 52.3%, Biology 34%, Chemistry 7.5% and Physics 6.1%. Nearly one-fifth (19.7%) of the sample were not successful in their selected science course. Less than two-fifths (37.7%) of student sample were not mathematics and/or reading competent. Academically in science intuitive types tended to do better than sensing types and feeling types tended to better than thinking types (NF 2.41, NT 2.36, SF 2.29 and ST 2.23). Further analysis found the TF preference scale contributed more toward the significant differences in reading

  3. Operation of bare HPGe detectors in LAr/LN2 for the GERDA experiment

    NASA Astrophysics Data System (ADS)

    Barnabé Heider, M.; Cattadori, C.; Chkvorets, O.; di Vacri, A.; Gusev, K.; Schönert, S.; Shirchenko, M.

    2008-11-01

    GERDA is designed to search for 0νββ-decay of 76Ge using high purity germanium detectors (HPGe), enriched (~ 85%) in 76Ge, directly immersed in LAr which acts both as shield against γ radiation and as cooling medium. The cryostat is located in a stainless steel water tank providing an additional shield against external background. The GERDA experiment aims at a background (b) lessapprox10-3 cts/(kg-y-keV) and energy resolution (FWHM) <= 4 keV at Qββ = 2039 keV. GERDA experiment is foreseen to proceed in two phases. For Phase I, eight reprocessed enriched HPGe detectors from the past HdM [C Balysh et al., Phys. Rev. D 66 (1997) 54] and IGEX [C E Aalseth et al., Phys. of Atomic Nuclei 63 (2000) 1225] experiments (~ 18 kg) and six reprocessed natural HPGe detectors (~ 15 kg) from the Genius Test-Facility [H V Klapdor et al., HIM A 481 (2002) 149] will be deployed in strings. GERDA aims at b lessapprox 10-2 cts/(kg·keV·y). With an exposure of ~ 15 kg·y of 76Ge and resolution ~ 3.6 keV, the sensitivity on the half-life will be T0ν1/2 3 · 1025 y (90 % C.L.) corresponding to mee < 270 meV [V A Rodin et al., Nucl. Phys. A 766 (2006) 107]. In Phase II, new diodes, able to discriminate between single- and multi-site events, will be added (~ 20 kg of 76Ge with intrinsic b ~ 10-2 cts/(kg·keV·y). With an exposure of ~ 120 kg·y, it is expected T0ν1/2 > 1.5 · 1026 y (90% C.L.) corresponding to mee < 110 meV [V A Rodin et al., Nucl. Phys. A 766 (2006) 107]. Three natural p-type HPGe prototypes (different passivation layer designs) are available in the GERDA underground facility at LNGS to investigate the effect of the detector assembly (low-mass low-activity holder), of the handling procedure and of the refurbishment technology on long term stability and spectroscopy performance. The study started on prototype 1 (fully passivated on the borehole side). 60Co γ-irradiation of the detector in LAr resulted in an increase of the leakage current (LC), depending on the

  4. Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance

    PubMed Central

    Zabolotny, Janice M.; Kim, Young-Bum; Peroni, Odile D.; Kim, Jason K.; Pani, Michael A.; Boss, Olivier; Klaman, Lori D.; Kamatkar, Shubhangi; Shulman, Gerald I.; Kahn, Barbara B.; Neel, Benjamin G.

    2001-01-01

    Previous reports indicate that the expression and/or activity of the protein-tyrosine phosphatase (PTP) LAR are increased in insulin-responsive tissues of obese, insulin-resistant humans and rodents, but it is not known whether these alterations contribute to the pathogenesis of insulin resistance. To address this question, we generated transgenic mice that overexpress human LAR, specifically in muscle, to levels comparable to those reported in insulin-resistant humans. In LAR-transgenic mice, fasting plasma insulin was increased 2.5-fold compared with wild-type controls, whereas fasting glucose was normal. Whole-body glucose disposal and glucose uptake into muscle in vivo were reduced by 39–50%. Insulin injection resulted in normal tyrosyl phosphorylation of the insulin receptor and insulin receptor substrate 1 (IRS-1) in muscle of transgenic mice. However, phosphorylation of IRS-2 was reduced by 62%, PI3′ kinase activity associated with phosphotyrosine, IRS-1, or IRS-2 was reduced by 34–57%, and association of p85α with both IRS proteins was reduced by 39–52%. Thus, overexpression of LAR in muscle causes whole-body insulin resistance, most likely due to dephosphorylation of specific regulatory phosphotyrosines on IRS proteins. Our data suggest that increased expression and/or activity of LAR or related PTPs in insulin target tissues of obese humans may contribute to the pathogenesis of insulin resistance. PMID:11309481

  5. Context-specific close-range "hoo" calls in wild gibbons (Hylobates lar).

    PubMed

    Clarke, Esther; Reichard, Ulrich H; Zuberbühler, Klaus

    2015-04-08

    Close range calls are produced by many animals during intra-specific interactions, such as during home range defence, playing, begging for food, and directing others. In this study, we investigated the most common close range vocalisation of lar gibbons (Hylobates lar), the 'hoo' call. Gibbons and siamangs (family Hylobatidae) are known for their conspicuous and elaborate songs, while quieter, close range vocalisations have received almost no empirical attention, perhaps due to the difficult observation conditions in their natural forest habitats. We found that 'hoo' calls were emitted by both sexes in a variety of contexts, including feeding, separation from group members, encountering predators, interacting with neighbours, or as part of duet songs by the mated pair. Acoustic analyses revealed that 'hoo' calls varied in a number of spectral parameters as a function of the different contexts. Males' and females' 'hoo' calls showed similar variation in these context-specific parameter differences, although there were also consistent sex differences in frequency across contexts. Our study provides evidence that lar gibbons are able to generate significant, context-dependent acoustic variation within their main social call, which potentially allows recipients to make inferences about the external events experienced by the caller. Communicating about different events by producing subtle acoustic variation within some call types appears to be a general feature of primate communication, which can increase the expressive power of vocal signals within the constraints of limited vocal tract flexibility that is typical for all non-human primates. In this sense, this study is of direct relevance for the on-going debate about the nature and origins of vocally-based referential communication and the evolution of human speech.

  6. Development of an ADC radiation tolerance characterization system for the upgrade of the ATLAS LAr calorimeter

    DOE PAGES

    Liu, Hong-Bin; Chen, Hu-Cheng; Chen, Kai; ...

    2017-02-01

    ATLAS LAr calorimeter will undergo its Phase-I upgrade during the long shutdown (LS2) in 2018, and a new LAr Trigger Digitizer Board (LTDB) will be designed and installed. Several commercial-off-the-shelf (COTS) multi-channel high-speed ADCs have been selected as possible backups of the radiation tolerant ADC ASICs for the LTDB. Here, to evaluate the radiation tolerance of these backup commercial ADCs, we developed an ADC radiation tolerance characterization system, which includes the ADC boards, data acquisition (DAQ) board, signal generator, external power supplies and a host computer. The ADC board is custom designed for different ADCs, with ADC drivers and clockmore » distribution circuits integrated on board. The Xilinx ZC706 FPGA development board is used as a DAQ board. The data from the ADC are routed to the FPGA through the FMC (FPGA Mezzanine Card) connector, de-serialized and monitored by the FPGA, and then transmitted to the host computer through the Gigabit Ethernet. A software program has been developed with Python, and all the commands are sent to the DAQ board through Gigabit Ethernet by this program. Two ADC boards have been designed for the ADC, ADS52J90 from Texas Instruments and AD9249 from Analog Devices respectively. TID tests for both ADCs have been performed at BNL, and an SEE test for the ADS52J90 has been performed at Massachusetts General Hospital (MGH). Test results have been analyzed and presented. The test results demonstrate that this test system is very versatile, and works well for the radiation tolerance characterization of commercial multi-channel high-speed ADCs for the upgrade of the ATLAS LAr calorimeter. It is applicable to other collider physics experiments where radiation tolerance is required as well.« less

  7. Development of an ADC radiation tolerance characterization system for the upgrade of the ATLAS LAr calorimeter

    NASA Astrophysics Data System (ADS)

    Liu, Hong-Bin; Chen, Hu-Cheng; Chen, Kai; Kierstead, James; Lanni, Francesco; Takai, Helio; Jin, Ge

    2017-02-01

    ATLAS LAr calorimeter will undergo its Phase-I upgrade during the long shutdown (LS2) in 2018, and a new LAr Trigger Digitizer Board (LTDB) will be designed and installed. Several commercial-off-the-shelf (COTS) multi-channel high-speed ADCs have been selected as possible backups of the radiation tolerant ADC ASICs for the LTDB. To evaluate the radiation tolerance of these backup commercial ADCs, we developed an ADC radiation tolerance characterization system, which includes the ADC boards, data acquisition (DAQ) board, signal generator, external power supplies and a host computer. The ADC board is custom designed for different ADCs, with ADC drivers and clock distribution circuits integrated on board. The Xilinx ZC706 FPGA development board is used as a DAQ board. The data from the ADC are routed to the FPGA through the FMC (FPGA Mezzanine Card) connector, de-serialized and monitored by the FPGA, and then transmitted to the host computer through the Gigabit Ethernet. A software program has been developed with Python, and all the commands are sent to the DAQ board through Gigabit Ethernet by this program. Two ADC boards have been designed for the ADC, ADS52J90 from Texas Instruments and AD9249 from Analog Devices respectively. TID tests for both ADCs have been performed at BNL, and an SEE test for the ADS52J90 has been performed at Massachusetts General Hospital (MGH). Test results have been analyzed and presented. The test results demonstrate that this test system is very versatile, and works well for the radiation tolerance characterization of commercial multi-channel high-speed ADCs for the upgrade of the ATLAS LAr calorimeter. It is applicable to other collider physics experiments where radiation tolerance is required as well. Supported by the U. S. Department of Energy (DE-SC001270)

  8. Anatomical failure following laparoscopic antireflux surgery (LARS); does it really matter?

    PubMed Central

    Dunne, N; Stratford, J; Jones, L; Sohampal, J; Robertson, R; Booth, MI; Dehn, TCB

    2010-01-01

    INTRODUCTION Failure rates of laparoscopic antireflux surgery (LARS) vary from 2–30%. A degree of anatomical failure is common, and the most common failure is intrathoracic wrap herniation. We have assessed anatomical integrity of the crural repair and wrap using marking Liga clips placed at the time of surgery and compared this with symptomatic outcome. PATIENTS AND METHODS A prospective study was undertaken on 50 patients who underwent LARS in a single centre over a 3-year period. Each had an X-ray on the first postoperative day and a barium swallow at 6 months at which the distance was measured between the marking Liga clips. An increase in interclip distance of > 25–49% was deemed ‘mild separation’, and an increase of > 50% ‘moderate separation’. Patients completed a standardised symptom questionnaire at 6 months. RESULTS At 6 months' postoperatively, 22% had mild separation of the crural repair with a mean Visick score of 1.18, and 54% had moderate separation with a mean Visick score of 1.26. Mild separation of the wrap occurred in 28% with a mean Visick score of 1.21 and 22% moderate separation with a mean Visick score of 1.18. Three percent had mild separation of both the crural repair and wrap with a mean Visick score of 1.0, and 16% moderate separation with a mean Visick score of 1.13. Of patients, 14% had evidence of some degree of failure on barium swallow but only one of these was significant intrathoracic migration of the wrap which was symptomatic and required re-do surgery. CONCLUSIONS The prevalence of some form of anatomical failure, as determined by an increase in the interclip distance, is high at 6 months' postoperatively following LARS. However, this does not seem to correlate with a subjective recurrence of symptoms. PMID:19995487

  9. SALTO: a randomized, multicenter study assessing octreotide LAR in inoperable bowel obstruction.

    PubMed

    Laval, Guillemette; Rousselot, Hubert; Toussaint-Martel, Sophie; Mayer, Françoise; Terrebonne, Eric; François, Eric; Brixi, Hédia; Nguyen, Thierry; Bourdeix, Isabelle; Bisot-Locard, Ségolène; Zelek, Laurent

    2012-02-01

    This phase II, multicenter, randomized, double-blind, non-comparative study assessed the efficacy and safety of immediate-release octreotide and octreotide LAR, in combination with corticosteroids and standard medical care, on the symptoms of inoperable malignant bowel obstruction (MBO) due to peritoneal carcinomatosis. The primary efficacy endpoint was "success" at day 14 defined as a composite endpoint including the absence of a nasogastric tube, and vomiting less than twice per day and no use of anticholinergic agents. Patients in the octreotide arm received octreotide LAR 30 mg intramuscular (im) on days 1, 29 and 57, as well as daily immediate-release octreotide 600 μg per day plus methylprednisolone on days 1 to 6. Placebo-treated patients received methylprednisolone and matched placebo instead of octreotide. Difficulties associated with enrolling patients at palliative-care stage meant only 64 patients (instead of the planned 102 patients) were randomized, 32 to octreotide and 32 to placebo. Despite randomization, more patients in the octreotide arm (46.4%) than in the placebo arm (21.9%) had a baseline Karnofsky score less than 50. An intention-to-treat analysis showed that in the octreotide and placebo arms, 12 (38%) and nine (28%), respectively, patients were successfully treated at day 14, which increased to 9/15 (60%) and 7/25 (28%), respectively, among patients with a baseline Karnofsky score greater or equal to 50. Octreotide-treated patients reported three drug-related adverse events (AEs), and no drug-related serious AEs or deaths. Octreotide LAR may have a key role in treating patients with a MBO due to peritoneal carcinomatosis, particularly in those with moderately severe disease.

  10. SN-detection in LAr-TPC and the quest for (ν-Ar) cross sections

    SciTech Connect

    Cavanna, F.

    2015-05-15

    Neutrino-nucleus cross sections are of relevance to supernova astrophysics. These cross-sections can be grouped into three categories, those that affect supernova dynamics, supernova nucleosynthesis, and terrestrial supernova neutrino detection, each of which would benefit from experimental study. In this report only the relevance of an accurate knowledge of neutrino-target nucleus cross sections for SN detection will be discussed, in particular for the case of Argon, the active target material of LAr-TPC detectors currently under construction or proposed for future very massive underground experiments.

  11. Recent R&D results on LAr LEM TPC and plans for LBNO demonstrators

    NASA Astrophysics Data System (ADS)

    Cantini, C.; Epprecht, L.; Gendotti, A.; Horikawa, S.; Murphy, S.; Natterer, G.; Periale, L.; Regenfus, C.; Resnati, F.; Rubbia, A.; Sergiampietri, F.; Viant, T.; Wu, S.; LAGUNA-LBNO Collaboration; WA105 Collaboration

    2015-11-01

    The double phase Liquid Argon (LAr) Time Projection Chamber (TPC) is the state-of-art technology for neutrino detection thanks to its superb 3 Dimensional (3D) tracking and calorimetry performance. Based on this technology, the Giant Liquid Argon Charge Imaging ExpeRiment (GLACIER) is proposed to be the far detector for the Long Baseline Neutrino Oscillation (LBNO) experiment aiming at studying neutrinos 2300 km away from their production point. We report recent R&D results on the charge readout system for GLACIER and the plans to build the GLACIER demonstrators at CERN.

  12. Development of COTS ADC SEE Test System for the ATLAS LArCalorimeter Upgrade

    DOE PAGES

    Hu, Xue -Ye; Chen, Hu -Cheng; Chen, Kai; ...

    2014-12-01

    Radiation-tolerant, high speed, high density and low power commercial off-the-shelf (COTS) analog-to-digital converters (ADCs) are planned to be used in the upgrade to the Liquid Argon (LAr) calorimeter front end (FE) trigger readout electronics. Total ionization dose (TID) and single event effect (SEE) are two important radiation effects which need to be characterized on COTS ADCs. In our initial TID test, Texas Instruments (TI) ADS5272 was identified to be the top performer after screening a total 17 COTS ADCs from different manufacturers with dynamic range and sampling rate meeting the requirements of the FE electronics. Another interesting feature of ADS5272more » is its 6.5 clock cycles latency, which is the shortest among the 17 candidates. Based on the TID performance, we have designed a SEE evaluation system for ADS5272, which allows us to further assess its radiation tolerance. In this paper, we present a detailed design of ADS5272 SEE evaluation system and show the effectiveness of this system while evaluating ADS5272 SEE characteristics in multiple irradiation tests. According to TID and SEE test results, ADS5272 was chosen to be implemented in the full-size LAr Trigger Digitizer Board (LTDB) demonstrator, which will be installed on ATLAS calorimeter during the 2014 Long Shutdown 1 (LS1).« less

  13. Development of COTS ADC SEE Test System for the ATLAS LArCalorimeter Upgrade

    SciTech Connect

    Hu, Xue -Ye; Chen, Hu -Cheng; Chen, Kai; Mead, Joseph; Liu, Shu -Bin; An, Qi

    2014-12-01

    Radiation-tolerant, high speed, high density and low power commercial off-the-shelf (COTS) analog-to-digital converters (ADCs) are planned to be used in the upgrade to the Liquid Argon (LAr) calorimeter front end (FE) trigger readout electronics. Total ionization dose (TID) and single event effect (SEE) are two important radiation effects which need to be characterized on COTS ADCs. In our initial TID test, Texas Instruments (TI) ADS5272 was identified to be the top performer after screening a total 17 COTS ADCs from different manufacturers with dynamic range and sampling rate meeting the requirements of the FE electronics. Another interesting feature of ADS5272 is its 6.5 clock cycles latency, which is the shortest among the 17 candidates. Based on the TID performance, we have designed a SEE evaluation system for ADS5272, which allows us to further assess its radiation tolerance. In this paper, we present a detailed design of ADS5272 SEE evaluation system and show the effectiveness of this system while evaluating ADS5272 SEE characteristics in multiple irradiation tests. According to TID and SEE test results, ADS5272 was chosen to be implemented in the full-size LAr Trigger Digitizer Board (LTDB) demonstrator, which will be installed on ATLAS calorimeter during the 2014 Long Shutdown 1 (LS1).

  14. VALOR joint oscillation analysis using multiple LAr-TPCs in the Booster Neutrino Beam at Fermilab

    NASA Astrophysics Data System (ADS)

    Andreopoulos, C.; Barry, C.; Bench, F.; Chappell, A.; Dealtry, T.; Dennis, S.; Escudero, L.; Jones, R.; Grant, N.; Roda, M.; Sgalaberna, D.; Shah, R.

    2017-09-01

    Anomalies observed by different experiments, the most significant ones being the ∼3.8 sigma νe appearance in a ∼50 MeV νµ beam from muon decay at rest observed by the LSND experiment and the ∼3.8 sigma νe and {\\bar{ν }}e appearance in a ∼1 GeV neutrino beam from pion decay in flight observed by MiniBooNE, suggest the existence of sterile neutrinos. The Short Baseline Neutrino (SBN) program at Fermilab aims to perform a sensitive search for sterile neutrinos by performing analyses of νe appearance and νµ disappearance employing three Liquid Argon Time Projection Chambers (LAr-TPCs) at different baselines. The VALOR neutrino fitting group was established within the T2K experiment and has led numerous flagship T2K oscillation analyses, and provided sensitivity and detector optimisation studies for DUNE and Hyper-K. The neutrino oscillation framework developed by this group is able to perform fits of several samples and systematic parameters within different neutrino models and experiments. Thus, VALOR is an ideal environment for the neutrino oscillation fits using multiple LAr-TPC detectors with proper treatment of correlated systematic uncertainties necessary for the SBN analyses.

  15. Resistance to octreotide LAR in acromegalic patients with high SSTR2 expression: analysis of AIP expression.

    PubMed

    Kasuki, Leandro; Colli, Leandro M; Elias, Paula C L; Castro, Margaret de; Gadelha, Mônica R

    2012-11-01

    We present here the clinical and molecular data of two patients with acromegaly treated with octreotide LAR after non-curative surgery, and who presented different responses to therapy. Somatostatin receptor type 2 and 5 (SSTR2 and SSTR5), and aryl hydrocarbon receptor-interacting protein (AIP) expression levels were analyzed by qPCR. In both cases, high SSTR2 and low SSTR5 expression levels were detected; however, only one of the patients achieved disease control after octreotide LAR therapy. When we analyzed AIP expression levels of both cases, the patient whose disease was controlled after therapy exhibited AIP expression levels that were two times higher than the patient whose disease was still active. These two cases illustrate that, although the currently available somatostatin analogs bind preferentially to SSTR2, some patients are not responsive to therapy despite high expression of this receptor. This difference could be explained by differences in post-receptor signaling pathways, including the recently described involvement of AIP.

  16. [Effects of exenatide lar in type 2 diabetes mellitus and obesity].

    PubMed

    Sierra Poyatos, Roberto; Riobó Serván, Pilar; Vázquez Martínez, Clotilde

    2014-10-24

    Introducción: Los análogos GLP-1 han demostrado ser un tratamiento eficaz en el tratamiento de la diabetes mellitus tipo 2 (DM-2) y la obesidad. Objetivo: Evaluar la eficacia de exenatide LAR sobre la pérdida de peso, control glucémico, tensión arterial (TA) y perfil lipídico, en DM-2 y obesidad. Material y métodos: Estudio retrospectivo de pacientes en tratamiento con exenatide LAR durante 6 meses. Se recogieron datos demográficos (edad, sexo), antropométricos, glucemia basal, hemoglobina glicada (HbA1c), tensión arterial y perfil lipídico al inicio y a los 6 meses de tratamiento. Se ha realizado un análisis de regresión logística para evaluar posibles factores predictores de eficacia. Resultados: 30 pacientes (17 varones, edad media: 61,7±9,5 años) con DM-2 de 9,7±6,2 años de evolución. La HbA1c se redujo en 1,3% (IC95% 1,04-1,57, p.

  17. Isolation and characterization of genes encoding leucoanthocyanidin reductase (FeLAR) and anthocyanidin reductase (FeANR) in buckwheat (Fagopyrum esculentum).

    PubMed

    Matsui, Katsuhiro; Hisano, Tomomi; Yasui, Yasuo; Mori, Masashi; Walker, Amanda R; Morishita, Toshikazu; Katsu, Kenjiro

    2016-10-20

    Proanthocyanidins (PAs) are a major group of flavonoids synthesized via the phenylpropanoid biosynthesis pathway, however the pathway has not been fully characterized in buckwheat. Anthocyanidin reductase (ANR) and leucoanthocyanidin reductase (LAR) are involved in the last steps of PA biosynthesis. To isolate the genes for these enzymes from buckwheat we performed PCR using degenerate primers and obtained cDNAs of ANR and LAR, which we designated FeANR and FeLAR1. A search for homologs in a buckwheat genome database with both sequences returned two more LAR sequences, designated FeLAR2 and FeLAR3. Linkage analysis with an F2 segregating population indicated that the three LAR loci were not genetically linked. We detected high levels of PAs in roots and cotyledons of buckwheat seedlings and in buds and flowers of mature plants. FeANR and FeLAR1-3 were expressed in most organs but had different expression patterns. Our findings would be useful for breeding and further analysis of PA synthesis and its regulation in buckwheat. Copyright © 2016 Elsevier GmbH. All rights reserved.

  18. Genetic and environmental influences on the continuous scales of the Myers-Briggs Type Indicator: an analysis based on twins reared apart.

    PubMed

    Bouchard, T J; Hur, Y M

    1998-04-01

    The Myers-Briggs Type Indicator was administered to a sample of 61 monozygotic twins reared apart (MZA), 49 dizygotic twins reared apart (DZA), and 92 spouses, who participated in the Minnesota Study of Twins Reared Apart (MISTRA) from 1979 to 1995. Twins' scores on the continuous scales were subjected to behavior genetic model-fitting procedures. Extraversion-Introversion and Thinking-Feeling yielded heritabilities of about .60, consisting largely of nonadditive genetic variance. Sensing-Intuition and Judgment-Perception yielded heritabilities of about .40, consisting largely of additive genetic variance. Spouse correlations for three of the four scales were near zero and not statistically significant; one spouse correlation (Sensing-Intuition) was modestly positive and statistically significant.

  19. Acromioclavicular joint reconstruction with the LARS ligament in professional versus non-professional athletes.

    PubMed

    Marcheggiani Muccioli, Giulio Maria; Manning, Christopher; Wright, Philip; Grassi, Alberto; Zaffagnini, Stefano; Funk, Lennard

    2016-06-01

    To compare outcomes of acromioclavicular (AC) joint reconstruction with ligament augmentation and reconstruction system (LARS) ligament in professional and non-professional athletes at 2-year minimum follow-up. Forty-three patients (men; mean age 30, range 19-54 years) with Rockwood type III to V chronic AC joint dislocations underwent AC joint reconstruction with LARS ligament and standardized rehabilitation. Patients were divided into two groups: professionals (22) and non-professionals (21). Clinical and radiological evaluations were performed preoperatively, at 3- and 24-month follow-up. All clinical (Oxford and Constant) scores and patient satisfaction improved significantly from preoperative to follow-up intervals (p < 0.00001). However, professionals showed nonsignificant improvements from 3- to 24-month follow-up in Constant. Although groups differed preoperatively in Constant (p = 0.037), they were not different in preoperative-to-postoperative differences in clinical scores, postoperative final satisfaction and median time to return to unrestricted activity [4 (interquartiler range 3-5) months to return to full sport in professionals]. Follow-up radiographs revealed an AC joint ratio (clavicle inferior-to-superior translation as ratio of AC joint height) of 0.09 and 0.16 in 8/22 professionals, 0.19 and 0.31 in 9/21 non-professionals, 0.14 and 0.24 in 17/43 overall patients at 3- and 24-month follow-up, respectively. Slight loss of reduction (0.25 < AC joint ratio < 0.50): 21 %. There were no significant clinical-radiographic correlations. Complication: one coracoid fracture at follow-up and one wound infection. AC joint reconstruction with LARS ligament did not reveal differences in clinical outcomes between groups, with 2 % of failures (re-dislocations) at 2-year minimum follow-up. Superior radiological outcomes in professionals were not correlated to clinical results. Therapeutic study-prospective comparative study, Level II.

  20. Search for space charge effects in the ICARUS T600 LAr-TPC

    NASA Astrophysics Data System (ADS)

    Torti, Marta

    2016-11-01

    Space charge in Liquid Argon Time Projection Chamber is due to the accumu- lation of positive ions, produced by ionizing tracks crossing the detector, which slowly flow toward the cathode. As a consequence, electric field distortions may arise, thus hindering the possibility to produce faithful 3D images of the ionizing events. The presence of space charge becomes relevant for large TPCs operating at surface or at shallow depths, where cosmic ray flux is high. These effects could interest the next phase of the ICARUS T600 detector, which will be deployed at shallow depths as a Far Detector for Short Baseline Neutrino experiment at FNAL dedicated to sterile neutrino searches. In 2001, the first ICARUS T600 module (T300) operated at surface in Pavia (Italy), recording cosmic ray data. In this work, a sample of cosmic muon tracks from the 2001 run was analyzed and results on space charge effects in LAr-TPCs are shown.

  1. Developing LAr Scintillation Light Collection Ideas in the Short Baseline Neutrino Detector

    SciTech Connect

    Szelc, A. M.

    2016-02-08

    Scintillation light is becoming the most rapidly developing feature of Liquid Argon Time Projection Chamber (LArTPC) neutrino detectors due to its capability to enhance and expand their physics reach traditionally based on charge readout. The SBND detector, set to be built on the Booster Neutrino Beam Line at Fermilab, is in a unique position to test novel liquid argon scintillation light readout systems in a detector with physics neutrino events. The different ideas under consideration by the collaboration are described, including an array of PMTs detecting direct light, SiPM coupled lightguide bars and a setup which uses PMTs/SiPMS and wavelength shifter covered reflector foils, as well as their respective strengths and physics foci and the benchmarks used to compare them.

  2. The big fat LARS - a LArge Reservoir Simulator for hydrate formation and gas production

    NASA Astrophysics Data System (ADS)

    Beeskow-Strauch, Bettina; Spangenberg, Erik; Schicks, Judith M.; Giese, Ronny; Luzi-Helbing, Manja; Priegnitz, Mike; Klump, Jens; Thaler, Jan; Abendroth, Sven

    2013-04-01

    Simulating natural scenarios on lab scale is a common technique to gain insight into geological processes with moderate effort and expenses. Due to the remote occurrence of gas hydrates, their behavior in sedimentary deposits is largely investigated on experimental set ups in the laboratory. In the framework of the submarine gas hydrate research project (SUGAR) a large reservoir simulator (LARS) with an internal volume of 425 liter has been designed, built and tested. To our knowledge this is presently a word-wide unique set up. Because of its large volume it is suitable for pilot plant scale tests on hydrate behavior in sediments. That includes not only the option of systematic tests on gas hydrate formation in various sedimentary settings but also the possibility to mimic scenarios for the hydrate decomposition and subsequent natural gas extraction. Based on these experimental results various numerical simulations can be realized. Here, we present the design and the experimental set up of LARS. The prerequisites for the simulation of a natural gas hydrate reservoir are porous sediments, methane, water, low temperature and high pressure. The reservoir is supplied by methane-saturated and pre-cooled water. For its preparation an external gas-water mixing stage is available. The methane-loaded water is continuously flushed into LARS as finely dispersed fluid via bottom-and-top-located sparger. The LARS is equipped with a mantle cooling system and can be kept at a chosen set temperature. The temperature distribution is monitored at 14 reasonable locations throughout the reservoir by Pt100 sensors. Pressure needs are realized using syringe pump stands. A tomographic system, consisting of a 375-electrode-configuration is attached to the mantle for the monitoring of hydrate distribution throughout the entire reservoir volume. Two sets of tubular polydimethylsiloxan-membranes are applied to determine gas-water ratio within the reservoir using the effect of permeability

  3. Noise Filtering and Signal Calibration in the MicroBooNE LArTPC

    NASA Astrophysics Data System (ADS)

    Joshi, Jyoti; Qian, Xin; MicroBooNE Collaboration Collaboration

    2017-01-01

    In large liquid argon time projection chambers (LArTPCs), TPC signal processing, which recovers the number of ionized electrons arriving at anode wire planes from the raw digitized induction signals, is a crucial step towards automated event reconstruction. The first stage of signal processing is the identification and removal of any excess TPC noise with minimal impact on the true signal. In this talk, first I will describe the characterization and software filtering techniques of various TPC noise observed in the raw digital signal data in MicroBooNE. I will then describe a novel drifted-charge extraction method based on 2D deconvolution technique. These techniques significantly enhance the performance of the induction wire planes in MicroBooNE.

  4. Detailed Hylobates lar karyotype defined by 25-color FISH and multicolor banding.

    PubMed

    Mrasek, Kristin; Heller, Anita; Rubtsov, Nikolai; Trifonov, Vladimir; Starke, Heike; Claussen, Uwe; Liehr, Thomas

    2003-08-01

    A comprehensive and detailed comparative chromosome map of the white-handed gibbon (Hylobates lar = HLA) has been established by hybridizing the recently developed complete human multicolor banding (MCB) probe set on metaphase chromosomes of a male HLA lymphoblastoid cell line. Thus, it was possible to precisely determine the breakpoints and distribution plus orientation of specific DNA-regions in this cytogenetically highly rearranged species compared to Homo sapiens (HSA). In general, the obtained results are in concordance with previous molecular-cytogenetic studies. In this study all 71 breakpoints present in HLA compared to HSA could be determined exactly. This study is a valuable complement to our knowledge on the phylogeny of huminoid chromosomes.

  5. The Pandora multi-algorithm approach to automated pattern recognition in LAr TPC detectors

    NASA Astrophysics Data System (ADS)

    Marshall, J. S.; Blake, A. S. T.; Thomson, M. A.; Escudero, L.; de Vries, J.; Weston, J.; MicroBooNE collaboration

    2017-09-01

    The development and operation of Liquid Argon Time Projection Chambers (LAr TPCs) for neutrino physics has created a need for new approaches to pattern recognition, in order to fully exploit the superb imaging capabilities offered by this technology. The Pandora Software Development Kit provides functionality to aid the process of designing, implementing and running pattern recognition algorithms. It promotes the use of a multi-algorithm approach to pattern recognition: individual algorithms each address a specific task in a particular topology; a series of many tens of algorithms then carefully builds-up a picture of the event. The input to the Pandora pattern recognition is a list of 2D Hits. The output from the chain of over 70 algorithms is a hierarchy of reconstructed 3D Particles, each with an identified particle type, vertex and direction.

  6. Controls on sinuosity in the sparsely vegetated Fossálar River, southern Iceland

    NASA Astrophysics Data System (ADS)

    Ielpi, Alessandro

    2017-06-01

    Vegetation exerts strong controls on fluvial sinuosity, providing bank stability and buffering surface runoff. These controls are manifest in densely vegetated landscapes, whereas sparsely vegetated fluvial systems have been so far overlooked. This study integrates remote sensing and gauging records of the meandering to wandering Fossálar River, a relatively steep-sloped (< 2.5%) Icelandic river featuring well-developed point bars (79%-85% of total active bar surface) despite the lack of thick, arborescent vegetation. Over four decades, fluctuations in the sinuosity index (1.15-1.43) and vegetation cover (63%-83%) are not significantly correlated (r = 0.28, p > 0.05), suggesting that relationships between the two are mediated by intervening variables and uncertain lag times. By comparison, discharge regime and fluvial planform show direct correlation over monthly to yearly time scales, with stable discharge stages accompanying the accretion of meander bends and peak floods related to destructive point-bar reworking. Rapid planform change is aided by the unconsolidated nature of unrooted alluvial banks, with recorded rates of lateral channel-belt migration averaging 18 m/yr. Valley confinement and channel mobility also control the geometry and evolution of individual point bars, with the highest degree of spatial geomorphic variability recorded in low-gradient stretches where lateral migration is unimpeded. Point bars in the Fossálar River display morphometric values comparable to those of other sparsely vegetated rivers, suggesting shared scalar properties. This conjecture prompts the need for more sophisticated integrations between remote sensing and gauging records on modern rivers lacking widespread plant life. While a large volume of experimental and field-based work maintains that thick vegetation has a critical role in limiting braiding, thus favouring sinuosity, this study demonstrates the stronger controls of discharge regime and alluvial morphology on

  7. Mutations in LARS2, encoding mitochondrial leucyl-tRNA synthetase, lead to premature ovarian failure and hearing loss in Perrault syndrome.

    PubMed

    Pierce, Sarah B; Gersak, Ksenija; Michaelson-Cohen, Rachel; Walsh, Tom; Lee, Ming K; Malach, Daniel; Klevit, Rachel E; King, Mary-Claire; Levy-Lahad, Ephrat

    2013-04-04

    The genetic causes of premature ovarian failure (POF) are highly heterogeneous, and causative mutations have been identified in more than ten genes so far. In two families affected by POF accompanied by hearing loss (together, these symptoms compose Perrault syndrome), exome sequencing revealed mutations in LARS2, encoding mitochondrial leucyl-tRNA synthetase: homozygous c.1565C>A (p.Thr522Asn) in a consanguineous Palestinian family and compound heterozygous c.1077delT and c.1886C>T (p.Thr629Met) in a nonconsanguineous Slovenian family. LARS2 c.1077delT leads to a frameshift at codon 360 of the 901 residue protein. LARS2 p.Thr522Asn occurs in the LARS2 catalytic domain at a site conserved from bacteria through mammals. LARS2 p.Thr629Met occurs in the LARS2 leucine-specific domain, which is adjacent to a catalytic loop critical in all species but for which primary sequence is not well conserved. A recently developed method of detecting remote homologies revealed threonine at this site in consensus sequences derived from multiple-species alignments seeded by human and E. coli residues at this region. Yeast complementation indicated that LARS2 c.1077delT is nonfunctional and that LARS2 p.Thr522Asn is partially functional. LARS2 p.Thr629Met was functional in this assay but might be insufficient as a heterozygote with the fully nonfunctional LARS2 c.1077delT allele. A known C. elegans strain with the protein-truncating alteration LARS-2 p.Trp247Ter was confirmed to be sterile. After HARS2, LARS2 is the second gene encoding mitochondrial tRNA synthetase to be found to harbor mutations leading to Perrault syndrome, further supporting a critical role for mitochondria in the maintenance of ovarian function and hearing. Copyright © 2013 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

  8. Assessment of personality type and medical specialty choice among medical students from Karachi; using Myers-Briggs Type Indicator (MBTI) tool.

    PubMed

    Jafrani, Sana; Zehra, Nosheen; Zehra, Muneeza; Abuzar Ali, Syed Muhmmad; Abubakar Mohsin, Saiyed Abdullah; Azhar, Rasheed

    2017-04-01

    To assess personality type of medical students and associate it with their choice of medical specialty. This cross-sectional study was conducted in February 2014 at one public and one private medical university of Karachi, and comprised medical students. A self- administered questionnaire based on Myers-Briggs type indicator was used to collect data which was analysed using SPSS 20. Of the 400 participants, there were 200(50%) each from public and private universities. Of all, 201(50.3%) students were found to be extroverted and 199(49.8%) were introverted personality types. Clinical fields were the main preference of students after their medical degree as selected by 317(79.2%) students; of the, Extroverted-Sensing-Feeling-Perceptive was the most common type identified in39(7.2%) students. Extroverted-Sensing-Feeling-Perceptive 11(2.8%), Extroverted-Sensing-Thinking-Judging 12(3%), Extroverted-Sensing-Feeling-Judging 5(1.3%), Introverted-Sensing-Feeling-Judging 6(1.5%), Introverted-Sensing-Thinking-Perceptive 7(1.8%) had preference for surgery, medicine, gynaecology, paediatrics and cardiology, respectively. Personality had significant impact on specialty and career choice.

  9. [Relationships between Myers-Briggs Type Indicator (MBTI) psychological type and marital satisfaction, divorce proneness, positive affect, and conflict regulation in clinic couples].

    PubMed

    Kong, Seong Sook

    2010-06-01

    The purpose of the study was to investigate the relationships between the Myers-Briggs Type Indicator (MBTI) psychological type and marital satisfaction, divorce proneness, positive affect, and conflict regulation in couple visiting a clinic. Couples (n=62) who visited "M" couple clinic participated in the study. Data were collected from March to June 2009 using the Marital Satisfaction Scale, Marital Status Inventory, Positive Affect Inventory, and Conflict Regulation Inventory. The couples showed no significant differences in marital satisfaction, positive affect, and conflict regulation according to similarities between spouses in MBTI types. However, they showed significant differences in divorce proneness of husband according to a similarity in the Sensing/Intuition indicator. They also showed significant differences in divorce proneness, positive affect, and conflict regulation between the couples for ISTJ (Introversion, Sensing, Thinking, Judging) or ESTJ (Extraversion, Sensing, Thinking, Judging) types compared to other couples. When nurses counsel couples, they should understand that differences in psychological type between spouses affects their marital relationship. In addition, nurses should educate couples on the characteristics of each type according to the couple's types and help them to understand each other, especially for couples where one spouse is the ISTJ/ESTJ type. These interventions will improve marital satisfaction and prevent the divorce in these couples.

  10. The first quantitative rating system of the antioxidant capacity of beauty creams via the Briggs-Rauscher reaction: a crucial step towards evidence-based cosmetics.

    PubMed

    Cecchi, Teresa; Cecchi, Patrizio; Passamonti, Paolo

    2011-02-07

    Oxidative damage is the primary cause of skin aging. Skin care products are numerous and overwhelming, yet there is certain similarity among different formulations. Moisturizers are ubiquitous and the presence of particular added ingredients supports specific marketing claims. The antioxidant effects of botanical polyphenols possess tremendous marketing appeal, because oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) and the skin ability to neutralize them. The concept of evidence-based cosmetics lacks a widely accepted method to estimate the antioxidant capacity of the beauty cream. This was the motive force of the present study: for the first time we put forth a quantitative rating system of skin care products. The overall antioxidant power of 75 widely used and advertised beauty creams was comparatively measured via the oscillating Briggs-Rauscher (BR) reaction. Many dermocosmetic products confirmed their ability to ensure protection against free radicals, even if differences among various creams are striking and often not correlated with the their price. The method we developed is simple and cheap and it can allow dermatologists and consumers to compare and choose effectively; on the other hand, producers can used this method to select the most active antioxidant cosmetic agent to optimise the product performance.

  11. The Joanna Briggs Institute best practice information sheet: the effectiveness of pelvic floor muscle exercises on urinary incontinence in women following childbirth.

    PubMed

    2011-09-01

    This Best Practice Information Sheet is derived from 21 studies and aims to synthesize the best available evidence on the effectiveness of pelvic floor muscle exercises on urinary incontinence in women following childbirth. The information that is contained in this sheet has been derived from studies that were included in a systematic review that was conducted by the Joanna Briggs Institute. The original references can be sourced from the systematic review. Pregnancy and childbirth are major risk factors for the development of urinary incontinence as the muscles of the pelvic floor become stretched and weakened. For some women, such incontinence after childbirth is temporary, but for others, their suffering can be of much longer-term duration. A number of risk factors has been identified for urinary incontinence following childbirth, including antenatal urinary incontinence, obesity, and significant perineal trauma. The aim of pelvic floor muscle exercises is to strengthen the perivaginal and perianal musculature in order to increase a woman's control of urinary leakage.

  12. Reaction routes leading to CO2 and CO in the Briggs-Rauscher oscillator: analogies between the oscillatory BR and BZ reactions.

    PubMed

    Muntean, Norbert; Szabó, Gabriella; Wittmann, Maria; Lawson, Thuy; Fülöp, János; Noszticzius, Zoltán; Onel, Lavinia

    2009-08-13

    With Fenton-type experiments, it is shown that the intense CO2/CO evolution in the Briggs-Rauscher (BR) reaction is due to decarboxylation/decarbonylation of organic free radicals. The metal ion applied in the Fenton-type experiments was Fe2+ or Ti3+ or Mn2+ combined with H2O2 or S2O(8)(2-) as a peroxide, whereas the organic substrate was malonic acid (MA) or a 1:1 mixture of MA and iodomalonic acid (IMA). Experiments with a complete BR system applying MA or the MA/IMA mixture indicate that practically all CO2 and CO comes from IMA. The decarboxylation/decarbonylation mechanisms of various iodomalonyl radicals can be analogous to that of the bromomalonyl radicals studied already in the Belousov-Zhabotinsky (BZ) reaction. It is found that an intense CO2/CO evolution requires the simultaneous presence of H2O2, IO3-, Mn2+, and IMA. It is suggested that the critical first step of this complex reaction takes place in the coordination sphere of Mn2+. That first step can initiate a chain reaction where organic and hydroperoxyl radicals are the chain carriers. A chain reaction was already found in a BZ oscillator as well. Therefore, the analogies between the BR and BZ oscillators are due to the fact that in both mechanisms, free radicals and, in most cases, also transition-metal complexes play an important role.

  13. Research and development for a free-running readout system for the ATLAS LAr Calorimeters at the high luminosity LHC

    NASA Astrophysics Data System (ADS)

    Hils, Maximilian; Atlas Liquid Argon Calorimeter Group

    2016-07-01

    The ATLAS Liquid Argon (LAr) Calorimeters were designed and built to measure electromagnetic and hadronic energy in proton-proton collisions produced at the Large Hadron Collider (LHC) at centre-of-mass energies up to 14 TeV and instantaneous luminosities up to 1034 cm-2 s-1. The High Luminosity LHC (HL-LHC) programme is now developed for up to 5-7 times the design luminosity, with the goal of accumulating an integrated luminosity of 3000 fb-1. In the HL-LHC phase, the increased radiation levels and an improved ATLAS trigger system require a replacement of the Front-end (FE) and Back-end (BE) electronics of the LAr Calorimeters. Results from research and development of individual components and their radiation qualification as well as the overall system design will be presented.

  14. Lanreotide Autogel 120 mg at extended dosing intervals in patients with acromegaly biochemically controlled with octreotide LAR: the LEAD study.

    PubMed

    Neggers, Sebastian J C M M; Pronin, Vyacheslav; Balcere, Inga; Lee, Moon-Kyu; Rozhinskaya, Liudmila; Bronstein, Marcello D; Gadelha, Mônica R; Maisonobe, Pascal; Sert, Caroline; van der Lely, Aart Jan

    2015-09-01

    To evaluate extended dosing intervals (EDIs) with lanreotide Autogel 120 mg in patients with acromegaly previously biochemically controlled with octreotide LAR 10 or 20 mg. Patients with acromegaly had received octreotide LAR 10 or 20 mg/4 weeks for ≥ 6 months and had normal IGF1 levels. Lanreotide Autogel 120 mg was administered every 6 weeks for 24 weeks (phase 1); depending on week-24 IGF1 levels, treatment was then administered every 4, 6 or 8 weeks for a further 24 weeks (phase 2). Hormone levels, patient-reported outcomes and adverse events were assessed. proportion of patients on 6- or 8-week EDIs with normal IGF1 levels at week 48 (study end). 107/124 patients completed the study (15 withdrew from phase 1 and two from phase 2). Of 124 patients enrolled, 77.4% were allocated to 6- or 8-week EDIs in phase 2 and 75.8% (95% CI: 68.3-83.3) had normal IGF1 levels at week 48 with the EDI (primary analysis). A total of 88.7% (83.1-94.3) had normal IGF1 levels after 24 weeks with 6-weekly dosing. GH levels were ≤ 2.5 μg/l in > 90% of patients after 24 and 48 weeks. Patient preferences for lanreotide Autogel 120 mg every 4, 6 or 8 weeks over octreotide LAR every 4 weeks were high. Patients with acromegaly achieving biochemical control with octreotide LAR 10 or 20 mg/4 weeks are possible candidates for lanreotide Autogel 120 mg EDIs. EDIs are effective and well received among such patients. © 2015 European Society of Endocrinology.

  15. A test of the Suits vegetative-canopy reflectance model with LARS soybean-canopy reflectance data

    NASA Technical Reports Server (NTRS)

    Chance, J. E.; Lemaster, E. W.

    1985-01-01

    The Suits vegetative-canopy reflectance model is tested with an extensive set of field reflectance measurements made by the Laboratory for Application of Remote Sensing (LARS) for soybean canopies. The model is tested for the full hemisphere of observer directions as well as the nadir direction. The results show moderate agreement for the visible channels of the Landsat MSS and poor agreement in the near-infrared channel of Landsat MSS. An analysis of errors is given.

  16. A More Reduced Mantle Source for Enriched Shergottites; Insights from the Olivine-Phyric Shergottite Lar 06319

    NASA Technical Reports Server (NTRS)

    Peslier, A. H.; Hnatyshin, D.; Herd, C. D. K.; Walton, E. L.; Brandon, A. D.; Lapen, T. J.; Shafer, J.

    2010-01-01

    A detailed petrographic study of melt inclusions and Cr-Fe-Ti oxides of LAR 06319 leads to two main conclusions: 1) this enriched oxidized olivine- phyric shergottite represents nearly continuous crystallization of a basaltic shergottite melt, 2) the melt became more oxidized during differentiation. The first crystallized mineral assemblages record the oxygen fugacity which is closest to that of the melt s mantle source, and which is lower than generally attributed to the enriched shergottite group.

  17. Gibbon (Hylobates lar) reintroduction success in Phuket, Thailand, and its conservation benefits.

    PubMed

    Osterberg, Petra; Samphanthamit, Phamon; Maprang, Owart; Punnadee, Suwit; Brockelman, Warren Y

    2015-05-01

    We summarize the results from a long-term gibbon reintroduction project in Phuket, Thailand, and evaluate its benefits to conservation. Between October 2002 and November 2012, eight breeding families of white-handed gibbons (Hylobates lar) were returned to the wild in Khao Phra Thaew non-hunting area (KPT). Wild gibbons were extirpated from Phuket Island by the early 1980s, but the illegal wildlife trade has continued to bring young gibbons from elsewhere to the island's popular tourist areas as pets and photo props. The Gibbon Rehabilitation Project (GRP) has rescued and rehabilitated confiscated and donated captive gibbons since 1992 and aims to repopulate the island's last sizable forest area. Following unsuccessful early attempts at translocation in the 1990s, GRP has now developed specific methods for gibbon reintroduction that have led to the establishment of a small independent, reproducing population of captive-raised and wild-born gibbons on Phuket. Eleven infants have been born wild within the reintroduced population, including a second generation wild-born gibbon in September 2012. Benefits of the GRP project include restoration of the gibbon population on Phuket, rescue of illegally kept gibbons, public education, training of personnel in gibbon conservation work, and gaining experience which may prove useful in saving more severely threatened species. It is unlikely that gibbon (and other large primate) translocations will make a significant contribution to conservation of the species as a whole, and primate translocation projects should not be judged solely by this criterion. © 2015 Wiley Periodicals, Inc.

  18. Translational research needs us to go back to basics and collaborate: interview with Lars Sundstrom

    PubMed Central

    Sundstrom, Lars

    2016-01-01

    Lars Sundstrom is Director of Enterprise and Translation at the West of England Academic Health Sciences Network [1] (UK), a Professor of Practice in Translational Medicine and Co-Director of the Elizabeth Blackwell Institute for Health Research at Bristol University [2] (UK), and an honorary Professor of Medicine at Cardiff University (UK). He has extensive experience in translational medicine and clinical neurosciences, holding positions at several eminent universities. He has also held executive and board-level positions at several SMEs, developing new therapeutics for neurological conditions and tools for drug discovery. He has also been an advisor to several UK and local government task forces and to the European Commission and the European Federation of Pharmaceutical Industry Associations. He was a founding member of the European Brain Council in Brussels, and set up the Severnside Alliance for Translational Research, developing a regional network partnership to link clinical and basic scientists. He was also involved in the creation of Health Research Wales. PMID:28031978

  19. Sterile pyuria in a population of wild white-handed gibbons (Hylobates lar).

    PubMed

    Beaman, Barbara A; Hesemeyer, Wyatt J; Dominy, Nathaniel J; Savini, Tommaso; Reichard, Ulrich H

    2009-10-01

    Urinalysis is an emerging method for monitoring the health and energy balance of wild primates. Here, we report the first urinalysis of wild gibbons. We used multi-reagent test strips to monitor the health status of 52 individual white-handed gibbons (Hylobates lar) inhabiting Khao Yai National Park, Thailand. Most urinary reference values were within normal ranges; however, regardless of age- and sex-class or monthly fruit productivity, we found unexpectedly high rates of urinary leukocytes (50% and 90% of individuals in 2001-2003 and 2006, respectively). In contrast to previous studies of African apes, this finding is coupled with the near absence of urinary nitrites, demonstrating pervasive levels of sterile pyuria. This result is the first reported case of sterile pyuria in a population of wild primates. The etiology of human sterile pyuria is diverse, but in all cases it is diagnostic of systemic inflammation. We discuss the potential causes of sterile pyuria in the gibbons of Khao Yai.

  20. The prevalence of Pediculus humanus capitis in two primary schools of Hacılar, Kayseri.

    PubMed

    Çetinkaya, Ülfet; Hamamcı, Berna; Delice, Safiye; Ercal, Barış Derya; Gücüyetmez, Süheyla; Yazar, Süleyman; Şahin, İzzet

    2011-01-01

    Pediculosis capitis is a worldwide public health concern, and today, head lice are seen in all socio-economic levels. The infestation usually occurs by head-to-head contact and children, primarily girls, aged 3-12 years are mostly affected. In the present study a total of 405 pupils (214 boys and 191 girls) from two pre- and primary schools in the Kayseri-Hacılar region were examined for pediculosis capitis during March 2010. Lice and/or eggs were detected by visual examination of the children's hair. Out of 405 children, 44 (10.9%) were infested with head lice. There were significant differences between the schools and the gender while no significant differences could be found between infestation and child's age, education of the parents, income of the family, housing type, source of water, and the presence or absence of a bathroom. Head lice remain a public health problem and more emphasis should be given to the education of parents regarding their biology and control.

  1. Catalytic Metallodrugs Based on the LaR2C Peptide Target HCV SLIV IRES RNA

    PubMed Central

    Ross, Martin James; Bradford, Seth S.; Cowan, J. A.

    2015-01-01

    Prior work has demonstrated the potential effectiveness of a new class of metallopeptides as catalytic metallodrugs that target HCV IRES SLIIb RNA (Cu-GGHYrFK, 1). Herein new catalytic metallodrugs (GGHKYKETDLLILFKDDYFAKKNEERK, 2; and GGHKYKETDL, 3) are described based on the LaR2C peptide that has been shown to bind to the SLIV HCV IRES domain. In vitro fluorescence assays yielded KD values ~10 μM for both peptides and reaction of the copper derivatives with SLIV RNA demonstrated initial rates comparable across different assays as well as displaying pseudo-Michaelis-Menten behavior. The sites of reaction and cleavage mechanisms were determined by MALDI-TOF mass spectrometry. The primary site of copper-promoted SLIV cleavage is shown to occur in the vicinity of the 5’-G17C18A19C20-3’ sequence that corresponds to a known binding site of the RM2 motif of the human La protein and has previously been reported to be important for viral translation. This domain also flanks the internal start codon (AUG). Both copper complexes also showed efficacy in an HCV replicon assay (IC50 = 0.75 μM for 2-Cu, and 2.17 μM for 3-Cu) and show potential for treatment of hepatitis C, complementing other marketed drugs by acting on a distinct therapeutic target by a novel mechanism of action. PMID:26583601

  2. Fatal human herpesvirus type 1 infection in a white-handed gibbon (Hylobates lar).

    PubMed

    Landolfi, Jennifer A; Wellehan, James F X; Johnson, April J; Kinsel, Michael J

    2005-07-01

    This report documents a case of spontaneous, fatal, and likely recrudescent human herpesvirus type 1 (HHV-1) infection in a captive white-handed gibbon (Hylobates lar) confirmed by polymerase chain reaction (PCR). An approximately 44-year-old, captive, female, white-handed gibbon with a history of recurrent conjunctivitis and occasional seizures became acutely weak, disoriented, and ataxic. A postictal state was suspected by caretakers and veterinary staff, and euthanasia was ultimately elected because of lack of clinical improvement with supportive care. No significant abnormalities were detected at necropsy. Histologically, sections of cerebrum and midbrain contained minimal to mild, multifocal lymphoplasmacytic meningoencephalitis with numerous intranuclear viral inclusions within astrocytes and some neurons. The presumptive diagnosis of HHV-1-induced encephalitis was strengthened by nested PCR amplification of a segment of the herpesvirus DNA polymerase gene. Sequences from this region have been found to be unique to each herpesvirus species, thus identifying HHV-1 as the likely etiologic agent in this case. Positive HHV-1 serology from several years before the terminal episode suggested that the disease was most likely due to recrudescence of latent HHV-1 infection.

  3. Fluid Flow Patterns During Production from Gas Hydrates in the Laboratory compared to Field Settings: LARS vs. Mallik

    NASA Astrophysics Data System (ADS)

    Strauch, B.; Heeschen, K. U.; Priegnitz, M.; Abendroth, S.; Spangenberg, E.; Thaler, J.; Schicks, J. M.

    2015-12-01

    The GFZ's LArge Reservoir Simulator LARS allows for the simulation of the 2008 Mallik gas hydrate production test and the comparison of fluid flow patterns and their driving forces. Do we see the gas flow pattern described for Mallik [Uddin, M. et al., J. Can. Petrol Tech, 50, 70-89, 2011] in a pilot scale test? If so, what are the driving forces? LARS has a network of temperature sensors and an electric resistivity tomography (ERT) enabling a good spatial resolution of gas hydrate occurrences, water and gas distribution, and changes in temperature in the sample. A gas flow meter and a water trap record fluid flow patterns and a backpressure valve has controlled the depressurization equivalent to the three pressure stages (7.0 - 5.0 - 4.2 MPa) applied in the Mallik field test. The environmental temperature (284 K) and confining pressure (13 MPa) have been constant. The depressurization induced immediate endothermic gas hydrate dissociation until re-establishment of the stability conditions by a consequent temperature decrease. Slight gas hydrate dissociation continued at the top and upper lateral border due to the constant heat input from the environment. Here transport pathways were short and permeability higher due to lower gas hydrate saturation. At pressures of 7.0 and 5.0 MPa the LARS tests showed high water flow rates and short irregular spikes of gas production. The gas flow patterns at 4.2 MPa and 3.0MPa resembled those of the Mallik test. In LARS the initial gas surges overlap with times of hydrate instability while water content and lengths of pathways had increased. Water production was at a minimum. A rapidly formed continuous gas phase caused the initial gas surges and only after gas hydrate dissociation decreased to a minimum the single gas bubbles get trapped before slowly coalescing again. In LARS, where pathways were short and no additional water was added, a transport of microbubbles is unlikely to cause a gas surge as suggested for Mallik.

  4. LAR tyrosine phosphatase receptor: alternative splicing is preferential to the nervous system, coordinated with cell growth and generates novel isoforms containing extensive CAG repeats

    PubMed Central

    1995-01-01

    Receptor-linked tyrosine phosphatases regulate cell growth by dephosphorylating proteins involved in tyrosine kinase signal transduction. The leukocyte common antigen-related (LAR) tyrosine phosphatase receptor has sequence similarity to the neural cell adhesion molecule N-CAM and is located in a chromosomal region (1p32- 33) frequently altered in neuroectodermal tumors. To understand the function of receptor-linked tyrosine phosphatases in neural development, we sought to identify LAR isoforms preferentially expressed in the nervous system and cellular processes regulating LAR alternative splicing. We report here the isolation of a series of rat LAR cDNA clones arising from complex combinatorial alternative splicing, not previously demonstrated for the tyrosine phosphatase- receptor gene family in general. Isoforms included: (a) deletions of the fourth, sixth and seventh fibronectin type III-like domains; (b) an alternatively spliced novel cassette exon in the fifth fibronectin type III-like domain; (c) two alternatively spliced novel cassette exons in the juxtamembrane region; (d) a retained intron in the extracellular region with in-frame stop codons predicting a secreted LAR isoform; and (e) an LAR transcript including an alternative 3' untranslated region containing multiple stretches of tandem CAG repeats up to 21 repeats in length. This number of repeats was in the range found in normal alleles of genes in which expansions of repeats are associated with neurodegenerative disease and the genetic phenomenon of anticipation. RT-PCR and Northern analysis demonstrated that LAR alternative splicing occurred preferentially in neuromuscular tissue in vivo and in neurons compared to astrocytes in vitro and was developmentally regulated. Alternative splicing was also regulated in PC12 cells by NGF, in 3T3 fibroblasts by cell confluence and in sciatic nerve and muscle subsequent to nerve transection. Western blot analysis demonstrated that alternatively spliced

  5. Characterizing the successful student in general chemistry and physical science classes in terms of Jung's personality types as identified by the Myers-Briggs Type Indicator

    NASA Astrophysics Data System (ADS)

    Riley, Wayne David

    1998-11-01

    A student's success in a science class can depend upon previous experiences, motivation, and the level of interest in the subject. Since psychological type is intrinsic to a person's whole being, it can be influential upon the student's motivation and interests. Thus, a study of student psychological types versus the level of success in a class, as measured by a percentage, has potential to uncover certain personality characteristics which may be helpful to or which may hinder a student's learning environment. This study was initiated, using the Myers-Briggs Type Indicator, to evaluate any correlation between a student's personality type and his/her performance in a science class. A total of 1041 students from three classes: Chemistry 121/122, Chemistry 112, Physical Science 100, volunteered for the study. An analysis of variance (ANOVA) was used to determine the levels of significance among sixteen personality types' averages. The results reveal that for the Chemistry 1121/122 course, the average score of the INTJ personality type was 5.1 to 12.6 points higher than every other personality type. The ANOVA identifies 3 personality types with averages significantly below the INTJ at the p < 0.05 significance level. The ANOVA analysis for the Chemistry 112 course identified significances between student scores at p = 0.08. The significance level for the differences among scores for the Physical Science 100 course was determined at a level of p = 0.02. Significance levels for p < 0.05 and <0.01 were identified between several groups in this course. The data suggest, that although personality type may not predict a particular student's success in a science class, students with certain personality traits may be favored in a chemistry class due the structure of the instruction and the presentation of the subject matter.

  6. Simulating the gas hydrate production test at Mallik using the pilot scale pressure reservoir LARS

    NASA Astrophysics Data System (ADS)

    Heeschen, Katja; Spangenberg, Erik; Schicks, Judith M.; Priegnitz, Mike; Giese, Ronny; Luzi-Helbing, Manja

    2014-05-01

    LARS, the LArge Reservoir Simulator, allows for one of the few pilot scale simulations of gas hydrate formation and dissociation under controlled conditions with a high resolution sensor network to enable the detection of spatial variations. It was designed and built within the German project SUGAR (submarine gas hydrate reservoirs) for sediment samples with a diameter of 0.45 m and a length of 1.3 m. During the project, LARS already served for a number of experiments simulating the production of gas from hydrate-bearing sediments using thermal stimulation and/or depressurization. The latest test simulated the methane production test from gas hydrate-bearing sediments at the Mallik test site, Canada, in 2008 (Uddin et al., 2011). Thus, the starting conditions of 11.5 MPa and 11°C and environmental parameters were set to fit the Mallik test site. The experimental gas hydrate saturation of 90% of the total pore volume (70 l) was slightly higher than volumes found in gas hydrate-bearing formations in the field (70 - 80%). However, the resulting permeability of a few millidarcy was comparable. The depressurization driven gas production at Mallik was conducted in three steps at 7.0 MPa - 5.0 MPa - 4.2 MPa all of which were used in the laboratory experiments. In the lab the pressure was controlled using a back pressure regulator while the confining pressure was stable. All but one of the 12 temperature sensors showed a rapid decrease in temperature throughout the sediment sample, which accompanied the pressure changes as a result of gas hydrate dissociation. During step 1 and 2 they continued up to the point where gas hydrate stability was regained. The pressure decreases and gas hydrate dissociation led to highly variable two phase fluid flow throughout the duration of the simulated production test. The flow rates were measured continuously (gas) and discontinuously (liquid), respectively. Next to being discussed here, both rates were used to verify a model of gas

  7. Sexual swellings in wild white-handed gibbon females (Hylobates lar) indicate the probability of ovulation.

    PubMed

    Barelli, Claudia; Heistermann, Michael; Boesch, Christophe; Reichard, Ulrich H

    2007-02-01

    Conspicuous sexual swellings in the females of some primate species have been a focus of scientific interest since Darwin first wrote about them in 1871. To understand these visual signals, research focused on exaggerated sexual swellings of Old World primates. However, some primate species develop much smaller sexual swellings and it is as yet unclear if these smaller swellings can serve similar functions as those proposed for exaggerated swellings, i.e. advertising fertility to attract mates. We studied the temporal patterns of sexual swellings, timing of ovulation and female reproductive status in wild white-handed gibbons (Hylobates lar) at Khao Yai National Park, Thailand, where this species has a variable social organization. We established fecal progestogen profiles in fifteen cycles of eight cycling females and, to detect swellings outside the menstrual cycle, five pregnant and six lactating females. In 80% of menstrual cycles, ovulation and maximum swelling phase (duration: Ø 9.3 days; 42.8% of cycle length), overlapped tightly. The probability of ovulation peaked on day 3 of the maximum swelling period. Nevertheless, the temporal relationship between maximum swelling and probability of ovulation varied from day -1 to day 13 of the swelling period and three times ovulations fell outside the maximum swelling phase. The different swellings phases occurred in similar proportions in cycling and pregnant, but not lactating females, which were rarely swollen. Despite their smaller size, gibbons' sexual swellings probably serve functions similar to those suggested for exaggerated swellings by the graded-signal hypothesis, which predicts that sexual swellings indicate the probability of ovulation, without allowing males to pinpoint its exact time.

  8. External forces and torques generated by the brachiating white-handed gibbon (Hylobates lar).

    PubMed

    Chang, Y H; Bertram, J E; Lee, D V

    2000-10-01

    We compared the kinetics of brachiation to bipedal walking and running. Gibbons use pectoral limbs in continuous contact with their overhead support at slow speeds, but exhibit aerial phases (or ricochetal brachiation) at faster speeds. This basic interaction between limb and support suggests some analogy to walking and running. We quantified the forces in three axes and torque about the vertical axis generated by a brachiating White-handed gibbon (Hylobates lar) and compared them with bipedal locomotion. Handholds oriented perpendicular to the direction of travel (as in ladder rungs) were spaced 0.80, 1.20, 1.60, 1.72, 1.95, and 2.25 m apart. The gibbon proportionally matched forward velocity to stride length. Handhold reaction forces resembled ground reaction forces of running humans except that the order of horizontal braking and propulsion were reversed. Peak vertical forces in brachiation increased with speed as in bipedal locomotion. In contrast to bipedalism, however, peak horizontal forces changed little with speed. Gait transition occurred within the same relative velocity range as the walk-run transition in bipeds (Froude number = 0.3-0.6). We oriented handholds parallel to the direction of travel (as in a continuous pole) at 0.80 and 1.60 m spacings. In ricochetal brachiation, the gibbon generated greater torque with handholds oriented perpendicular as opposed to parallel to the direction of travel. Handhold orientation did not affect peak forces. The similarities and differences between brachiation and bipedalism offer insight into the ubiquity of mechanical principles guiding all limbed locomotion and the distinctiveness of brachiation as a unique mode of locomotion. Copyright 2000 Wiley-Liss, Inc.

  9. Geochemistry and sources of fluoride and nitrate contamination of groundwater in Lar area, south Iran.

    PubMed

    Rezaei, Mohsen; Nikbakht, Masume; Shakeri, Ata

    2017-06-01

    Groundwater quality in bone-dry and semiarid areas of Iran is decreasing because of contaminants from natural origins and anthropogenic sources. Among many harmful contaminants, nitrate and fluoride ions are more common. This study was carried out with the aim of determining geochemical processes controlling chemistry of groundwater with special reference to nitrate and fluoride enrichment in groundwater in Lar plain aquifer, south of Iran. Groundwater samples were collected from 17 sites and analyzed for main constituents (Na, K, Ca, Mg, Cl, SO4(2-), HCO3(-), F(-), and NO3(-)). Composite diagram, saturation indices calculation, and multivariate analysis techniques including cluster and factor analyses were employed in evaluating groundwater quality. The EC ranges from 8793.87 to 13,345.00 μS/cm in wet season and from 9621.59 to 12,640.00 μS/cm in dry season. Fluoride amounts range between 0.59 and 3.92 mg/L. Nitrate concentrations range between 1.47 and 70.66 mg/L. Results indicate that dissolution-precipitation of carbonate and evaporate minerals, evaporation (in terms of agricultural water return), and opposite ion interchange are the main processes that determine groundwater chemistry. It seems that fluoride has a natural origin and the equilibrium reaction between fluorite and calcite is very significant to control fluoride concentration level in water. Vertical variation of nitrate concentration and distribution of agricultural areas have indicated that nitrate originated from nitrogenous inorganic fertilizers used during irrigation periods. The results also indicate that denitrification takes place in the aquifer and that nitrate decline is not only a function of dilution but also a process of denitrification.

  10. Stages of rootless cone formation observed within the Raudhólar cone group, Iceland

    NASA Astrophysics Data System (ADS)

    Fitch, E. P.; Hamilton, C.; Fagents, S. A.; Thordarson, T.

    2013-12-01

    Secondary (rootless) cones form when lava interacts explosively with water contained in the substrate, and represent a largely degassed, end-member system that can elucidate mechanisms of magma-water interactions in the absence of primary degassing-induced fragmentation. Rootless cones are well documented in Iceland. The Raudhólar rootless cone group, located within the ~5200-year-old Ellidaá lava flow on the south-eastern outskirts of Reykjavík, was extensively quarried during the Second World War and now provides excellent cross-sections through the tephra sequences. Taking advantage of this exposure, we performed detailed stratigraphic, grain-size, and componentry analyses, which suggest that the energetics of rootless explosions vary substantially during cone formation. The lower unit contains the most substrate sediment and is characterized by dilute pyroclastic density current deposits. The middle unit is dominated by a succession of bed-pairs, each containing a finer-grained lower layer and coarser-grained upper layer. In the upper unit, the succession grades into a welded section that caps the cone. The abundance of substrate sediment generally decreases upwards within the cone, which suggests that the efficiency of lava-substrate mixing decreased with time. In addition, clast size generally increases upwards within the cone, implying that the fragmentation energy also decreased as the rootless eruption progressed. Both lines of evidence suggest that the explosions decreased in intensity with time, likely due to the depletion of available groundwater. However, alternating fine- and coarse-grained beds imply cycles of increased and decreased fragmentation efficiency, which we attribute to groundwater recharge and depletion during the event. Therefore, this study presents a detailed look at rootless cone formation and provides the foundation for future work on this important, yet understudied, system.

  11. Histological reconstruction of dental development and age at death in a juvenile gibbon (Hylobates lar).

    PubMed

    Dirks, W

    1998-01-01

    Although research on dental development in great apes and modern humans has provided comparative models for life history, growth and development in hominin evolution, almost nothing is known about dental development in their sister group, the hylobatids. Hylobatids are of interest because they differ in important life history variables from other catarrhines of similar body mass, and can help to provide more general models for the factors underlying patterns of dental development. This study uses histological techniques to reconstruct developmental sequence, crown formation times, root extension rates, daily rates of enamel and dentine formation, and age at death in a single specimen of Hylobates lar. Thin sections were prepared of permanent mandibular teeth and analyzed by polarized light microscopy. Age at death was determined to be 2.88 yrs calibrated from a pattern of accentuated growth increments. At this age, permanent teeth in occlusion include I1, I2, and M1. Developing permanent teeth include C1, P3, P4, and M2. P3 lags behind P4 in development, and there is no indication of M3 present in the crypt. Differences between the gibbon specimen and great apes include greater prenatal development of M1, accelerated incisor development relative to molars and prenatal development of I1, no overlap between M2 and M3 crown development, shorter crown formation times, and slower root extension rates of 4-5 micron daily in the molars. Root extension rates are higher in the incisors. The periodicity of growth increments is four days, more similar to macaques than to other hominoids. Daily formation rates for enamel of 1.2-4.9 micron and dentine of 1.7-4.9 micron are similar to those reported for other catarrhines.

  12. A study of the atmospheric dispersion of a high release of krypton-85 above a complex coastal terrain, comparison with the predictions of Gaussian models (Briggs, Doury, ADMS4).

    PubMed

    Leroy, C; Maro, D; Hébert, D; Solier, L; Rozet, M; Le Cavelier, S; Connan, O

    2010-11-01

    Atmospheric releases of krypton-85, from the nuclear fuel reprocessing plant at the AREVA NC facility at La Hague (France), were used to test Gaussian models of dispersion. In 2001-2002, the French Institute for Radiological Protection and Nuclear Safety (IRSN) studied the atmospheric dispersion of 15 releases, using krypton-85 as a tracer for plumes emitted from two 100-m-high stacks. Krypton-85 is a chemically inert radionuclide. Krypton-85 air concentration measurements were performed on the ground in the downwind direction, at distances between 0.36 and 3.3 km from the release, by neutral or slightly unstable atmospheric conditions. The standard deviation for the horizontal dispersion of the plume and the Atmospheric Transfer Coefficient (ATC) were determined from these measurements. The experimental results were compared with calculations using first generation (Doury, Briggs) and second generation (ADMS 4.0) Gaussian models. The ADMS 4.0 model was used in two configurations; one takes account of the effect of the built-up area, and the other the effect of the roughness of the surface on the plume dispersion. Only the Briggs model correctly reproduced the measured values for the width of the plume, whereas the ADMS 4.0 model overestimated it and the Doury model underestimated it. The agreement of the models with measured values of the ATC varied according to distance from the release point. For distances less than 2 km from the release point, the ADMS 4.0 model achieved the best agreement between model and measurement; beyond this distance, the best agreement was achieved by the Briggs and Doury models.

  13. Octreotide LAR treatment of acromegaly in "real life": long-term outcome at a tertiary care center.

    PubMed

    Espinosa-de-los-Monteros, Ana Laura; Gonzalez, Baldomero; Vargas, Guadalupe; Sosa, Ernesto; Mercado, Moises

    2015-06-01

    To report our day-to day experience with the long-term use of octreotide LAR in the treatment of acromegaly. Patients with acromegaly managed between 2003 and 2012 with octreotide LAR for a median of 27 months (interquartile ranges 12-60) and who had not received radiation therapy or concomitant treatment with cabergoline were retrospectively evaluated. Both primarily treated patients (n = 33) and patients who received octreotide after failed pituitary surgery (adjunctive treatment, n = 124) were included. Full biochemical response was defined as the achievement of a GH <2.5 ng/mL and an IGF-1 <1.2 times the upper limit of normal (× ULN); we also evaluated efficacy using a GH cut off of <1 ng/mL. Over 60% of the patients achieved a GH of <2.5 ng/mL. The combined GH (<2.5 ng/mL) and IGF-1 (<1.2 × ULN) target was achieved by 35.5 and 33.6% of the patients treated primarily and adjunctively, respectively; these figures dropped to 22.6 and 23% when using a GH target of <1 ng/mL. All patients reported a significant improvement in acromegalic symptoms. Lower pretreatment GH and IGF-1 levels were both associated with a higher probability of achieving the composite biochemical target. Currently recommended GH and IGF-1 targets are reached by <36% of patients treated with octreotide LAR in a day-to day practice context. Nevertheless, in most instances a clinical benefit and an improvement in biochemical markers can be clearly documented.

  14. The physiological concentration of ferrous iron (II) alters the inhibitory effect of hydrogen peroxide on CD45, LAR and PTP1B phosphatases.

    PubMed

    Kuban-Jankowska, Alicja; Gorska, Magdalena; Jaremko, Lukasz; Jaremko, Mariusz; Tuszynski, Jack A; Wozniak, Michal

    2015-12-01

    Hydrogen peroxide is an important regulator of protein tyrosine phosphatase activity via reversible oxidation. However, the role of iron in this reaction has not been yet elucidated. Here we compare the influence of hydrogen peroxide and the ferrous iron (reagent for Fenton reaction) on the enzymatic activity of recombinant CD45, LAR, PTP1B phosphatases and cellular CD45 in Jurkat cells. The obtained results show that ferrous iron (II) is potent inhibitor of CD45, LAR and PTP1B, but the inhibitory effect is concentration dependent. We found that the higher concentrations of ferrous iron (II) increase the inactivation of CD45, LAR and PTP1B phosphatase caused by hydrogen peroxide, but the addition of the physiological concentration (500 nM) of ferrous iron (II) has even a slightly preventive effect on the phosphatase activity against hydrogen peroxide.

  15. Octreotide LAR and Prednisone as Neoadjuvant Treatment in Patients with Primary or Locally Recurrent Unresectable Thymic Tumors: A Phase II Study

    PubMed Central

    Kirzinger, Lukas; Boy, Sandra; Marienhagen, Jörg; Schuierer, Gerhard; Neu, Reiner; Ried, Michael; Hofmann, Hans-Stefan; Wiebe, Karsten; Ströbel, Philipp; May, Christoph; Kleylein-Sohn, Julia; Baierlein, Claudia; Bogdahn, Ulrich; Marx, Alexander; Schalke, Berthold

    2016-01-01

    Therapeutic options to cure advanced, recurrent, and unresectable thymomas are limited. The most important factor for long-term survival of thymoma patients is complete resection (R0) of the tumor. We therefore evaluated the response to and the induction of resectability of primarily or locally recurrent unresectable thymomas and thymic carcinomas by octreotide Long-Acting Release (LAR) plus prednisone therapy in patients with positive octreotide scans. In this open label, single-arm phase II study, 17 patients with thymomas considered unresectable or locally recurrent thymoma (n = 15) and thymic carcinoma (n = 2) at Masaoka stage III were enrolled. Octreotide LAR (30 mg once every 2 weeks) was administered in combination with prednisone (0.6 mg/kg per day) for a maximum of 24 weeks (study design according to Fleming´s one sample multiple testing procedure for phase II clinical trials). Tumor size was evaluated by volumetric CT measurements, and a decrease in tumor volume of at least 20% at week 12 compared to baseline was considered as a response. We found that octreotide LAR plus prednisone elicited response in 15 of 17 patients (88%). Median reduction of tumor volume after 12 weeks of treatment was 51% (range 20%–86%). Subsequently, complete surgical resection was achieved in five (29%) and four patients (23%) after 12 and 24 weeks, respectively. Octreotide LAR plus prednisone treatment was discontinued in two patients before week 12 due to unsatisfactory therapeutic effects or adverse events. The most frequent adverse events were gastrointestinal (71%), infectious (65%), and hematological (41%) complications. In conclusion, octreotide LAR plus prednisone is efficacious in patients with primary or recurrent unresectable thymoma with respect to tumor regression. Octreotide LAR plus prednisone was well tolerated and adverse events were in line with the known safety profile of both agents. PMID:27992479

  16. Octreotide LAR and Prednisone as Neoadjuvant Treatment in Patients with Primary or Locally Recurrent Unresectable Thymic Tumors: A Phase II Study.

    PubMed

    Kirzinger, Lukas; Boy, Sandra; Marienhagen, Jörg; Schuierer, Gerhard; Neu, Reiner; Ried, Michael; Hofmann, Hans-Stefan; Wiebe, Karsten; Ströbel, Philipp; May, Christoph; Kleylein-Sohn, Julia; Baierlein, Claudia; Bogdahn, Ulrich; Marx, Alexander; Schalke, Berthold

    2016-01-01

    Therapeutic options to cure advanced, recurrent, and unresectable thymomas are limited. The most important factor for long-term survival of thymoma patients is complete resection (R0) of the tumor. We therefore evaluated the response to and the induction of resectability of primarily or locally recurrent unresectable thymomas and thymic carcinomas by octreotide Long-Acting Release (LAR) plus prednisone therapy in patients with positive octreotide scans. In this open label, single-arm phase II study, 17 patients with thymomas considered unresectable or locally recurrent thymoma (n = 15) and thymic carcinoma (n = 2) at Masaoka stage III were enrolled. Octreotide LAR (30 mg once every 2 weeks) was administered in combination with prednisone (0.6 mg/kg per day) for a maximum of 24 weeks (study design according to Fleming´s one sample multiple testing procedure for phase II clinical trials). Tumor size was evaluated by volumetric CT measurements, and a decrease in tumor volume of at least 20% at week 12 compared to baseline was considered as a response. We found that octreotide LAR plus prednisone elicited response in 15 of 17 patients (88%). Median reduction of tumor volume after 12 weeks of treatment was 51% (range 20%-86%). Subsequently, complete surgical resection was achieved in five (29%) and four patients (23%) after 12 and 24 weeks, respectively. Octreotide LAR plus prednisone treatment was discontinued in two patients before week 12 due to unsatisfactory therapeutic effects or adverse events. The most frequent adverse events were gastrointestinal (71%), infectious (65%), and hematological (41%) complications. In conclusion, octreotide LAR plus prednisone is efficacious in patients with primary or recurrent unresectable thymoma with respect to tumor regression. Octreotide LAR plus prednisone was well tolerated and adverse events were in line with the known safety profile of both agents.

  17. SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3–LAR adhesion

    PubMed Central

    Lie, Eunkyung; Ko, Ji Seung; Choi, Su-Yeon; Roh, Junyeop Daniel; Cho, Yi Sul; Noh, Ran; Kim, Doyoun; Li, Yan; Kang, Hyeyeon; Choi, Tae-Yong; Nam, Jungyong; Mah, Won; Lee, Dongmin; Lee, Seong-Gyu; Kim, Ho Min; Kim, Hyun; Choi, Se-Young; Um, Ji Won; Kang, Myoung-Goo; Bae, Yong Chul; Ko, Jaewon; Kim, Eunjoon

    2016-01-01

    Synaptic adhesion molecules regulate various aspects of synapse development, function and plasticity. These functions mainly involve trans-synaptic interactions and positive regulations, whereas cis-interactions and negative regulation are less understood. Here we report that SALM4, a member of the SALM/Lrfn family of synaptic adhesion molecules, suppresses excitatory synapse development through cis inhibition of SALM3, another SALM family protein with synaptogenic activity. Salm4-mutant (Salm4−/−) mice show increased excitatory synapse numbers in the hippocampus. SALM4 cis-interacts with SALM3, inhibits trans-synaptic SALM3 interaction with presynaptic LAR family receptor tyrosine phosphatases and suppresses SALM3-dependent presynaptic differentiation. Importantly, deletion of Salm3 in Salm4−/− mice (Salm3−/−; Salm4−/−) normalizes the increased excitatory synapse number. These results suggest that SALM4 negatively regulates excitatory synapses via cis inhibition of the trans-synaptic SALM3–LAR adhesion. PMID:27480238

  18. Mice lacking leukocyte common antigen-related (LAR) protein tyrosine phosphatase domains demonstrate spatial learning impairment in the two-trial water maze and hyperactivity in multiple behavioural tests.

    PubMed

    Kolkman, Marloes J M; Streijger, Femke; Linkels, Marianne; Bloemen, Marjon; Heeren, Dick J; Hendriks, Wiljan J A J; Van der Zee, Catharina E E M

    2004-09-23

    Leukocyte common antigen-related (LAR) protein is a cell adhesion molecule-like receptor-type protein tyrosine phosphatase. We previously reported that in LAR tyrosine phosphatase-deficient (LAR-Delta P) mice the number and size of basal forebrain cholinergic neurons as well as their innervation of the hippocampal area was reduced. With the hippocampus being implicated in behavioural activity aspects, including learning and memory processes, we assessed possible phenotypic consequences of LAR phosphatase deficiency using a battery of rodent behaviour tests. Motor function and co-ordination tests as well as spatial learning ability assays did not reveal any performance differences between wildtype and LAR-Delta P mice. A spatial learning impairment was found in the difficult variant of the Morris water maze. Exploration, nestbuilding and activity tests indicated that LAR-Delta P mice were more active than wildtype littermates. The observed hyperactivity in LAR-Delta P mice could not be explained by altered anxiety or curiosity levels, and was found to be persistent throughout the nocturnal period. In conclusion, behavioural testing of the LAR-Delta P mice revealed a spatial learning impairment and a significant increase in activity.

  19. Briggs, Henry (1561-1630)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Mathematician, born in Worley Wood, Yorkshire, England. Professor at Cambridge, London (Gresham College) and Oxford. By pointing out how much more useful logarithms would be if (unlike JOHN NAPIER's original invention) they were to base 10, he was responsible for improving astronomers' ability to calculate. Published mathematical tables (logarithms, sines, tangents, secants) as an aid to such ca...

  20. Age related decline in female lar gibbon great call performance suggests that call features correlate with physical condition.

    PubMed

    Terleph, Thomas A; Malaivijitnond, S; Reichard, U H

    2016-01-05

    White-handed gibbons (Hylobates lar) are small Asian apes known for living in stable territories and producing loud, elaborate vocalizations (songs), often in well-coordinated male/female duets. The female great call, the most conspicuous phrase of the repertoire, has been hypothesized to function in intra-sexual territorial defense. We therefore predicted that characteristics of the great call would correlate with a caller's physical condition, and thus might honestly reflect resource holding potential (RHP). Because measurement of RHP is virtually impossible for wild animals, we used age as a proxy, hypothesizing that great call climaxes are difficult to produce and maintain over time, and that older adults will therefore perform lower quality great calls than young adults. To test this we analyzed the great call climaxes of 15 wild lar gibbon females at Khao Yai National Park, Thailand and 2 captive females at Leo Conservation Center, Greenwich, CT. Findings show that call climaxes correlate with female age, as young animals (n = 8, mean age: 12.9 years) produced climaxes with a higher frequency range (delta F0), maximum F0 frequency and duty cycle than old animals (n = 9, mean age: 29.6 years). A permuted discriminant function analysis also correctly classified calls by age group. During long song bouts the maximum F0 frequency of great call climaxes' also decreased. Additional data support the hypothesis that short high notes, associated with rapid inhalation as an individual catches its breath, reflect increased caller effort. Older females produced more high notes than younger females, but the difference only approached statistical significance, suggesting that calling effort may be similar across different ages. Finally, for the first time in this species, we measured peak intensity of calls in captive females. They were capable of producing climaxes in excess of 100 dB at close range (2.7 m). Age and within-bout differences in the lar gibbon

  1. High-Fat Diet Augments VPAC1 Receptor-Mediated PACAP Action on the Liver, Inducing LAR Expression and Insulin Resistance.

    PubMed

    Nakata, Masanori; Zhang, Boyang; Yang, Yifei; Okada, Takashi; Shintani, Norihito; Hashimoto, Hitoshi; Yada, Toshihiko

    2016-01-01

    Pituitary adenylate cyclase-activating polypeptide (PACAP) acts on multiple processes of glucose and energy metabolism. PACAP potentiates insulin action in adipocytes and insulin release from pancreatic β-cells, thereby enhancing glucose tolerance. Contrary to these effects at organ levels, PACAP null mice exhibit hypersensitivity to insulin. However, this apparent discrepancy remains to be solved. We aimed to clarify the mechanism underlying the antidiabetic phenotype of PACAP null mice. Feeding with high-fat diet (HFD) impaired insulin sensitivity and glucose tolerance in wild type mice, whereas these changes were prevented in PACAP null mice. HFD also impaired insulin-induced Akt phosphorylation in the liver in wild type mice, but not in PACAP null mice. Using GeneFishing method, HFD increased the leukocyte common antigen-related (LAR) protein tyrosine phosphatase in the liver in wild type mice. Silencing of LAR restored the insulin signaling in the liver of HFD mice. Moreover, the increased LAR expression by HFD was prevented in PACAP null mice. HFD increased the expression of VPAC1 receptor (VPAC1-R), one of three PACAP receptors, in the liver of wild type mice. These data indicate that PACAP-VPAC1-R signaling induces LAR expression and insulin resistance in the liver of HFD mice. Antagonism of VPAC1-R may prevent progression of HFD-induced insulin resistance in the liver, providing a novel antidiabetic strategy.

  2. High-Fat Diet Augments VPAC1 Receptor-Mediated PACAP Action on the Liver, Inducing LAR Expression and Insulin Resistance

    PubMed Central

    Nakata, Masanori; Zhang, Boyang; Yang, Yifei; Okada, Takashi; Shintani, Norihito; Hashimoto, Hitoshi

    2016-01-01

    Pituitary adenylate cyclase-activating polypeptide (PACAP) acts on multiple processes of glucose and energy metabolism. PACAP potentiates insulin action in adipocytes and insulin release from pancreatic β-cells, thereby enhancing glucose tolerance. Contrary to these effects at organ levels, PACAP null mice exhibit hypersensitivity to insulin. However, this apparent discrepancy remains to be solved. We aimed to clarify the mechanism underlying the antidiabetic phenotype of PACAP null mice. Feeding with high-fat diet (HFD) impaired insulin sensitivity and glucose tolerance in wild type mice, whereas these changes were prevented in PACAP null mice. HFD also impaired insulin-induced Akt phosphorylation in the liver in wild type mice, but not in PACAP null mice. Using GeneFishing method, HFD increased the leukocyte common antigen-related (LAR) protein tyrosine phosphatase in the liver in wild type mice. Silencing of LAR restored the insulin signaling in the liver of HFD mice. Moreover, the increased LAR expression by HFD was prevented in PACAP null mice. HFD increased the expression of VPAC1 receptor (VPAC1-R), one of three PACAP receptors, in the liver of wild type mice. These data indicate that PACAP-VPAC1-R signaling induces LAR expression and insulin resistance in the liver of HFD mice. Antagonism of VPAC1-R may prevent progression of HFD-induced insulin resistance in the liver, providing a novel antidiabetic strategy. PMID:28044141

  3. Observations on the behavior of gibbons (Hylobates leucogenys, H. gabriellae, and H. lar) in the presence of mirrors.

    PubMed

    Ujhelyi, M; Merker, B; Buk, P; Geissmann, T

    2000-09-01

    Three captive gibbons (Hylobates leucogenys, H. gabriellae, and H. lar) were videotaped in the course of longitudinal exposure to mirrors introduced into their familiar cage or island housing situation. The gibbons, which differed in age, sex, species, and rearing condition, exhibited great individual differences in their behavioral reactions to mirrors, spanning from a minimal reaction dominated by social responses to a dramatic sequence of progressive behavioral change that featured a variety of contingency testing behaviors and included mirror-mediated, self-directed behavior. Additional information on the mirror competence of gibbons was provided by modified mark tests and a hidden object task. The results are discussed in relation to current criteria for self-recognition in primates and factors involved in individual and species differences in reactions to mirror exposure.

  4. The effect of 1 month of therapy with midodrine, octreotide-LAR and albumin in refractory ascites: a pilot study.

    PubMed

    Tandon, Puneeta; Tsuyuki, Ross T; Mitchell, Lesley; Hoskinson, Michael; Ma, Mang M; Wong, Winnie W; Mason, Andrew L; Gutfreund, Klaus; Bain, Vincent G

    2009-02-01

    The pathogenesis of refractory ascites (RA) is linked to splanchnic vasodilation. We hypothesized that a combination of midodrine, octreotide long-acting release (LAR) and albumin would result in increased natriuresis, better control of ascites and an improvement in renal function in patients with RA+/-Type 2 hepatorenal syndrome. A prospective pilot study in patients with RA as defined by the International Ascites Club. Consecutive patients received an intramuscular injection of octreotide-LAR, 50 g of albumin three times per week and midodrine titrated to increase the systolic blood pressure for 1 month. Ten patients with RA were enrolled and eight with complete data to 1 month post-treatment were included in the analysis. There was no change in renal function but there was a trend towards a reduction in the volume of ascites removed by paracentesis (P=0.08) and a significant reduction in the plasma renin (P=0.01) and aldosterone concentrations (P=0.01). Interestingly, there was a transient worsening in the model for end-stage liver disease (MELD) score (P=0.01). The deterioration in MELD was completely reversible after discontinuation of therapy. To our knowledge, this is the first study of prolonged midodrine, octreotide and albumin therapy in RA. We observed a significant reduction in the plasma renin and aldosterone concentrations and a trend towards a reduction in the volume of ascites removed by paracentesis without an effect on renal function. The beneficial effects are at the expense of a reversible deterioration in the MELD score. Large controlled trials are needed before this therapy can be routinely recommended.

  5. Discontinuation of octreotide LAR after long term, successful treatment of patients with acromegaly: is it worth trying?

    PubMed

    Ramírez, Claudia; Vargas, Guadalupe; González, Baldomero; Grossman, Ashley; Rábago, Julia; Sosa, Ernesto; Espinosa-de-Los-Monteros, Ana Laura; Mercado, Moisés

    2012-01-01

    Somatostatin analogs (SA) have been used for over 25 years in the treatment of acromegaly. A major disadvantage is the need to continue therapy indefinitely. To evaluate the feasibility of discontinuing therapy in well-controlled patients with acromegaly treated chronically with SA. Of the 205 subjects on octreotide LAR, we selected those who met the following criteria: two or more years of treatment, a stable dose and injection interval of 20  mg every 8 weeks or longer for the previous year, no history of radiation, no cabergoline for the previous 6 months, a GH <1.5  ng/ml, and an IGF1 <1.2×upper limit of normal (ULN). Octreotide LAR was stopped and both GH and IGF1 were measured monthly for 4 months; a glucose-suppressed GH value and magnetic resonance imaging were obtained at the 4th month, thereafter, basal GH and IGF1 were measured q. 3 months, for 12-18 months. Patients were removed from the study if GH or IGF1 rose to 1.5  ng/ml or 1.2×ULN respectively. Twelve patients (ten women, mean age 48±13 years) were studied. Seven patients (58.3%) relapsed biochemically within 1 year of having stopped the SA; two patients relapsed by GH and IGF1 criteria, the remaining five patients kept GH levels within target. Five patients (41.7%) remain in remission after 12 months of follow-up. Non-recurring patients were on longer injection intervals but no other characteristic was associated with a successful withdrawal. Withdrawal of SA is possible in a small but distinct subset of patients, particularly in those who are very well controlled on relatively low doses administered at long intervals.

  6. Relationships between Myers-Briggs type indicator measure of psychological type and neo measure of big five personality factors in Polish University students: a preliminary cross-cultural comparison.

    PubMed

    Tobacyk, Jerome J; Livingston, Mary M; Robbins, James E

    2008-10-01

    English-language versions of the Myers-Briggs Type Indicator (Form G) measure of psychological type and the NEO-FFI measure of the Big Five personality factors were completed by 57 Polish university students fluent in the English language. The pattern of correlations between MBTI and NEO-FFI scales for the Polish sample was compared to the pattern of correlations for measures of these same constructs reported for Americans. Four of the five significant relationships between MBTI and NEO-FFI scales reported in the American sample were also recorded in the Polish sample: MBTI Extraversion-Introversion with NEO Extraversion, MBTI Sensing-Intuition and MBTI Judging-Perceiving with NEO-Openness, and MBTI Judging-Perceiving with NEO Conscientiousness. Pending replication with a larger, more representative sample, this preliminary study supports the validity of psychological type in Polish society.

  7. Magmatic history and parental melt composition of olivine-phyric shergottite LAR 06319: Importance of magmatic degassing and olivine antecrysts in Martian magmatism

    NASA Astrophysics Data System (ADS)

    Balta, J. Brian; Sanborn, Matthew; McSween, Harry Y.; Wadhwa, Meenakshi

    2013-08-01

    Several olivine-phyric shergottites contain enough olivine that they could conceivably represent the products of closed-system crystallization of primary melts derived from partial melting of the Martian mantle. Larkman Nunatak (LAR) 06319 has been suggested to represent a close approach to a Martian primary liquid composition based on approximate equilibrium between its olivine and groundmass. To better understand the olivine-melt relationship and the evolution of this meteorite, we report the results of new petrographic and chemical analyses. We find that olivine megacryst cores are generally not in equilibrium with the groundmass, but rather have been homogenized by diffusion to Mg# 72. We have identified two unique grain types: an olivine glomerocryst and an olivine grain preserving a primary magmatic boundary that constrains the time scale of eruption to be on the order of hours. We also report the presence of trace oxide phases and phosphate compositions that suggest that the melt contained approximately 1.1% H2O and lost volatiles during cooling, also associated with an increase in oxygen fugacity upon degassing. We additionally report in situ rare earth element measurements of the various mineral phases in LAR 06319. Based on these reported trace element abundances, we estimate the oxygen fugacity in the LAR 06319 parent melt early in its crystallization sequence (i.e., at the time of crystallization of the low-Ca and high-Ca pyroxenes), the rare earth element composition of the parent melt, and those of melts in equilibrium with later formed phases. We suggest that LAR 06319 represents the product of closed-system crystallization within a shallow magma chamber, with additional olivine accumulated from a cumulate pile. We infer that the olivine megacrysts are antecrysts, derived from a single magma chamber, but not directly related to the host magma, and suggest that mixing of antecrysts within magma chambers may be a common process in Martian magmatic

  8. The allelic variant of LAR gene promoter -127 bp T-->A is associated with reduced risk of obesity and other features related to insulin resistance.

    PubMed

    Miscio, Giuseppe; Tassi, Vittorio; Coco, Angelo; Soccio, Teresa; Di Paola, Rosa; Prudente, Sabrina; Baratta, Roberto; Frittitta, Lucia; Ludovico, Ornella; Padovano, Libera; Dallapiccola, Bruno; Di Mario, Umberto; De Cosmo, Salvatore; Trischitta, Vincenzo

    2004-07-01

    Insulin resistance, which is pathogenic for type 2 diabetes (T2D), is under the control of largely unknown genetic determinants. LAR, a protein-tyrosine phosphatase which inhibits insulin signalling, is overexpressed in animal and human models of insulin resistance. We studied the entire sequence of the LAR gene by SSCP analysis and automatic DNA sequencing, with the aim of verifying whether its sequence variants might be associated with insulin resistance. In the 276 bp sequence upstream of the transcriptional start site (i.e. a region we have identified as having basal promoter activity) a -127 bp T-->A SNP (5% frequency) was associated with lower body mass index (BMI) ( P=0.03), waist circumference ( P=0.01), blood pressure ( P=0.01) and urinary albumin/creatinine ratio ( P=0.04) in 589 non-diabetic unrelated individuals from the Gargano region (central east coast of Italy). To quantify the risk for a high body weight conferred by the -127 T-->A SNP, the whole cohort was divided into tertiles according to the individual BMI. The risk of belonging to the heavier tertile, as compared to the leaner one, was reduced by approximately 60%. In a population from East Sicily ( n=307), T/A genotype carriers ( n=13) showed lower triglyceride levels ( P=0.04) and higher insulin sensitivity as indicated by lower plasma glucose ( P=0.03) and serum insulin ( P=0.006) during oral glucose tolerance testing (OGTT). Promoter activity, studied by cDNA transfection experiments, was similar for the A and T alleles. In conclusion, a genetic variant of the LAR gene promoter is consistently associated with features of insulin resistance in two different Caucasian populations. Although the biological relevance of this variant has yet to be determined, this finding underlines the potential importance of the LAR gene in dysregulation of insulin sensitivity and related disorders.

  9. Rb-Sr and Sm-Nd Studies of Olivine-Phyric Shergottites RBT 04262 and LAR 06319: Isotopic Evidence for Relationship to Enriched Basaltic Shergottites

    NASA Technical Reports Server (NTRS)

    Nyquist, L.E.; Shih, C.-Y.; Reese, Y.

    2009-01-01

    RBT 04262 and LAR 06319 are two Martian meteorites recently discovered in Antarctica. Both contain abundant olivines, and were classified as olivine-phyric shergottites. A detailed petrographic study of RBT 04262 suggested it should be reclassified as a lherzolitic shergottite. However, the moderately LREE-depleted REE distribution pattern indicated that it is closely related to enriched basaltic shergottites like Shergotty, Zagami, Los Angeles, etc. In earlier studies of a similarly olivinephyric shergottite NWA 1068 which contains 21% modal olivine, it was shown that it probably was produced from an enriched basaltic shergottite magma by olivine accumulation . As for LAR 06319, recent petrographic studies suggested that it is different from either lherzolitic shergottites or the highly LREE-depleted olivine-phyric shergottites. We performed Rb-Sr and Sm-Nd isotopic analyses on RBT 04262 and LAR 06319 to determine their crystallization ages and Sr and Nd isotopic signatures, and to better understand the petrogenetic relationships between them and other basaltic, lherzolitic and depleted olivine-phyric shergottites.

  10. Deep-Sea Phylogeographic Structure Shaped by Paleoenvironmental Changes and Ongoing Ocean Currents Around the Sea of Japan in a Crangonid Shrimp, Argis lar.

    PubMed

    Fujita, Junta; Drumm, David T; Iguchi, Akira; Ueda, Yuji; Yamashita, Yuho; Ito, Masaki; Tominaga, Osamu; Kai, Yoshiaki; Ueno, Masahiro; Yamashita, Yoh

    2017-10-01

    The deep-sea crangonid shrimp, Argis lar, is a highly abundant species from the northern Pacific Ocean. We investigated its phylogeographic and demographic structure across the species' extensive range, using mitochondrial DNA sequence variation to evaluate the impact of deep-sea paleoenvironmental dynamics in the Sea of Japan on population histories. The haplotype network detected three distinct lineages with allopatric isolation, which roughly corresponded to the Sea of Japan (Lineage A), the northwestern Pacific off the Japanese Archipelago (Lineage B), and the Bering Sea/Gulf of Alaska (Lineage C). Lineage A showed relatively low haplotype and nucleotide diversity, a significantly negative value of Tajima's D, and a star-shaped network, suggesting that anoxic bottom-water in the Sea of Japan over the last glacial period may have brought about a reduction in the Sea of Japan population. Furthermore, unexpectedly, the distributions of Lineage A and B were closely related to the pathways of the two ocean currents, especially along the Sanriku Coast. This result indicated that A. lar could disperse across shallow straits through the ocean current, despite their deep-sea adult habitat. Bayesian inference of divergence time revealed that A. lar separated into three lineages approximately 1 million years before present (BP) in the Pleistocene, and then had been influenced by deep-sea paleoenvironmental change in the Sea of Japan during the last glacial period, followed by a more recent larval dispersal with the ocean current since ca. 6 kilo years BP.

  11. First Independent Replication of the Involvement of LARS2 in Perrault Syndrome by Whole-Exome Sequencing of an Italian Family

    PubMed Central

    Soldà, Giulia; Caccia, Sonia; Robusto, Michela; Chiereghin, Chiara; Castorina, Pierangela; Ambrosetti, Umberto; Duga, Stefano; Asselta, Rosanna

    2015-01-01

    Perrault syndrome (MIM #233400) is a rare autosomal recessive disorder characterized by ovarian dysgenesis and primary ovarian insufficiency in females, and progressive hearing loss in both genders. Recently, mutations in five genes (HSD17B4, HARS2, CLPP, LARS2, and C10ORF2) were found to be responsible for Perrault syndrome, although they do not account for all cases of this genetically heterogeneous condition. We used whole-exome sequencing to identify pathogenic variants responsible for Perrault syndrome in an Italian pedigree with two affected siblings. Both patients were compound heterozygous for two novel missense variants within the mitochondrial leucyl-tRNA synthetase (LARS2), NM_015340.3:c.899C>T(p.Thr300Met) and c.1912G>A(p.Glu638Lys). Both variants co-segregated with the phenotype in the family. p.Thr300 and p.Glu638 are evolutionary conserved residues, and are located respectively within the editing domain and immediately before the catalytically important KMSKS motif. Homology modeling using as template the E. coli leucyl-tRNA synthetase provided further insights on the possible pathogenic effects of the identified variants. This represents the first independent replication of the involvement of LARS2 mutations in Perrault syndrome, contributing valuable information for the further understanding of this disease. PMID:26657938

  12. PoLAR Voices: Informing Adult Learners about the Science and Story of Climate Change in the Polar Regions Through Audio Podcast

    NASA Astrophysics Data System (ADS)

    Quinney, A.; Murray, M. S.; Gobroski, K. A.; Topp, R. M.; Pfirman, S. L.

    2015-12-01

    The resurgence of audio programming with the advent of podcasting in the early 2000s spawned a new medium for communicating advances in science, research, and technology. To capitalize on this informal educational outlet, the Arctic Institute of North America partnered with the International Arctic Research Center, the University of Alaska Fairbanks, and the UA Museum of the North to develop a podcast series called PoLAR Voices for the Polar Learning and Responding (PoLAR) Climate Change Education Partnership. PoLAR Voices is a public education initiative that uses creative storytelling and novel narrative structures to immerse the listener in an auditory depiction of climate change. The programs will feature the science and story of climate change, approaching topics from both the points of view of researchers and Arctic indigenous peoples. This approach will engage the listener in the holistic story of climate change, addressing both scientific and personal perspectives, resulting in a program that is at once educational, entertaining and accessible. Feedback is being collected at each stage of development to ensure the content and format of the program satisfies listener interests and preferences. Once complete, the series will be released on thepolarhub.org and on iTunes. Additionally, blanket distribution of the programs will be accomplished via radio broadcast in urban, rural and remote areas, and in multiple languages to increase distribution and enhance accessibility.

  13. Cross-species amplification of human microsatellite markers using noninvasive samples from white-handed gibbons (Hylobates lar).

    PubMed

    Chambers, Karen E; Reichard, Ulrich H; Möller, Asja; Nowak, Katrin; Vigilant, Linda

    2004-09-01

    Analysis of the population genetic structure and reproductive strategies of various primate species has been facilitated by cross-species amplification (i.e., the use of microsatellite markers developed in one species for analysis of another). In this study we screened 47 human-derived markers to assess their utility in the white-handed gibbon (Hylobates lar). Only eight produced accurate, reliable results, and exhibited levels of polymorphism that were adequate for individual identification. This low success rate was surprising given that human microsatellite markers typically work well in species (such as macaques) that are evolutionarily more distant from humans than are gibbons. In addition, we experienced limited success in using a set of microsatellite markers that have been reported to be useful in the closely-related H. muelleri, and applying our set of microsatellite markers to samples obtained from one H. pileatus individual. Our results emphasize the importance of extensively screening potential markers in representatives of the population of interest.

  14. Brief communication: Three-dimensional motion analysis of hindlimb during brachiation in a white-handed gibbon (Hylobates lar).

    PubMed

    Oka, Kenji; Hirasaki, Eishi; Hirokawa, Yohko; Nakano, Yoshihiko; Kumakura, Hiroo

    2010-08-01

    In brachiating gibbons, it is thought that there is little movement in the hindlimb joints and that lateral body movement is quite limited. These hypotheses are based on naked-eye observations, and no quantitative motion analyses of the hindlimbs have been reported. This study quantitatively describes the three-dimensional movements of the lower trunk and distal thigh during continuous-contact brachiation in a white-handed gibbon (Hylobates lar) to evaluate the roles of the trunk and hindlimb. The results revealed that the lower trunk moved both laterally and vertically. The lateral movement of the lower trunk resulted from the lateral inclination of the trunk by gravity. The vertical movement of the trunk was converted into forward velocity, indicating an exchange between potential and kinetic energy. We also observed flexion and extension of the hip, although the excursion was within a small range. In addition, the lateral movement of the hindlimb in thedirection opposite to that of trunk movement helped to reduce the lateral sway of the body. These results suggest that during continuous-contact brachiation a gibbon uses hip flexion and extension motions to increase the kinetic energy in the swing. In addition, fine motions of the hip may restrict the lateral sway of the center of body mass. Copyright 2010 Wiley-Liss, Inc.

  15. Effects of social status and stress on patterns of gastrointestinal parasitism in wild white-handed gibbons (Hylobates lar).

    PubMed

    Gillespie, Thomas R; Barelli, Claudia; Heistermann, Michael

    2013-04-01

    Although gibbons (family Hylobatidae) are typically monogamous, polyandrous groups occur regularly. Stress associated with elevated intragroup competition among males in polyandrous groups may increase susceptibility to infectious disease. To better understand this interplay, as well as to provide the first comprehensive assessment of parasitism in free-ranging gibbons, we characterized the richness of gastrointestinal parasites and examined their prevalence in males from 14 groups (10 pair-living, 4 multi-male) of white-handed gibbons (Hylobates lar) at Khao Yai National Park, Thailand. From September 2008 to May 2009, 324 fecal samples were collected from 23 individually recognizable male gibbons and screened for gastrointestinal helminths and protozoa after isolation via fecal floatation, sedimentation, and immunofluorescent antibody detection. A total of 10 parasite species recovered, including seven nematodes, two protozoans, and one trematode. Parasite richness and species-specific prevalence were examined relative to social organization (pair-living vs. multi-male), male status (primary vs. secondary), age (subadult, adult, senior), fecal glucocorticoid levels, and time of the year. No relationship was found between parasite richness and sociodemographic or physiological factors. Similarly, prevalence of infection with parasite species was not associated with the majority of sociodemographic factors; however, Ternidens sp. and Balantidium coli varied seasonally and Trichuris sp. decreased with increasing age. Moreover, observational data suggest that competition is low in this gibbon population, and our findings are consistent with those observations in that cooperative defense may offset stress and reduce susceptibility to infection. Copyright © 2013 Wiley Periodicals, Inc.

  16. Analysis of Spatial-Temporal Variation of Land Surface Temperature, Vegetation and Snow Cover in Lar National Park of Iran

    NASA Astrophysics Data System (ADS)

    Arekhi, M.

    2016-10-01

    Changes in land surface reflectance measured by remote sensing data can be useful in climate change studies. This study attempts to analyze the spatial-temporal extent change of vegetation greenness, Land Surface Temperature (LST), and Normalized Difference Snow Index (NDSI) in late spring at the Lar National Park of Iran using Landsat data. Vegetation indices (VIs), LST, and NDSI maps were calculated for each date (1985, 1994, 2010, and 2015). All VIs have shown an increasing trend from 1985 to 2015 which depicted increase of vegetation. Spectral reflectance of all bands is declining from 1985 to 2015 except in near-infrared (NIR) bands. High reflectance in NIR bands is due to increased vegetation greenness. The reduction was seen in the visible bands that show increased vegetation photosynthetic activity. In the short-wave infrared bands (SWIR) were observed reduced trend from 1985 to 2015 which is indicate increased vegetation. Also, in the mid-wave infrared (MWIR) bands were observed a declining trend which is the result of decreasing soil fraction from 1985 to 2015. LST has increased from 23.27 °C in 1985 to 27.45 °C in 2015. Snow patches were decreased over the study period. In conclusion, VIs and surface reflectance bands are considered the main tool to display vegetation change. Also, high VIs values showed healthy and dense vegetation. The results of our study will provide valuable information in preliminary climate change studies.

  17. Kinetics of low-density lipoprotein receptor activity in Hep-G2 cells: derivation and validation of a Briggs-Haldane-based kinetic model for evaluating receptor-mediated endocytotic processes in which receptors recycle.

    PubMed Central

    Harwood, H J; Pellarin, L D

    1997-01-01

    The process of receptor-mediated endocytosis for receptors that recycle to the cell surface in an active form can be considered as being kinetically analogous to that of a uni-substrate, uni-product enzyme-catalysed reaction. In this study we have derived steady-state initial-velocity rate equations for this process, based on classical Briggs-Haldane and King-Altman kinetic approaches to multi-step reactions, and have evaluated this kinetic paradigm, using as a model system the low-density lipoprotein (LDL)-receptor-mediated endocytosis of the trapped label [14C]sucrose-LDL in uninduced, steady-state Hep-G2 cells. Using the derived rate equations, together with experimentally determined values for Bmax (123 fmol/mg of cell protein), Kd (14.3 nM), the endocytotic rate constant ke (analogous to kcat; 0.163 min-1), Km (80 nM) and maximal internalization velocity (26.4 fmol/min per mg), we have calculated the ratio ke/Km (0.00204 nM-1.min-1), the bimolecular rate constant for LDL and LDL-receptor association (0. 00248 nM-1.min-1), the first-order rate constant for LDL-LDL-receptor complex dissociation (0.0354 min-1), the total cellular content of LDL receptors (154 fmol/mg of cell protein), the intracellular LDL receptor concentration (30.7 fmol/mg of cell protein) and the pseudo-first-order rate constant for LDL receptor recycling (0.0653 min-1). Based on this mathematical model, the kinetic mechanism for the receptor-mediated endocytosis of [14C]sucrose-LDL by steady-state Hep-G2 cells is one of constitutive endocytosis via independent internalization sites that follows steady-state Briggs-Haldane kinetics, such that LDL-LDL-receptor interactions are characterized by a rapid-high-affinity ligand-receptor association, followed by ligand-receptor complex internalization that is rapid relative to complex dissociation, and by receptor recycling that is more rapid than complex internalization and that serves to maintain 80% of cellular LDL receptors on the cell surface in

  18. Michel electron reconstruction using cosmic-ray data from the MicroBooNE LArTPC

    NASA Astrophysics Data System (ADS)

    Acciarri, R.; Adams, C.; An, R.; Anthony, J.; Asaadi, J.; Auger, M.; Bagby, L.; Balasubramanian, S.; Baller, B.; Barnes, C.; Barr, G.; Bass, M.; Bay, F.; Bishai, M.; Blake, A.; Bolton, T.; Bugel, L.; Camilleri, L.; Caratelli, D.; Carls, B.; Castillo Fernandez, R.; Cavanna, F.; Chen, H.; Church, E.; Cianci, D.; Cohen, E.; Collin, G. H.; Conrad, J. M.; Convery, M.; Crespo-Anadón, J. I.; Del Tutto, M.; Devitt, D.; Dytman, S.; Eberly, B.; Ereditato, A.; Escudero Sanchez, L.; Esquivel, J.; Fleming, B. T.; Foreman, W.; Furmanski, A. P.; Garcia-Gamez, D.; Garvey, G. T.; Genty, V.; Goeldi, D.; Gollapinni, S.; Graf, N.; Gramellini, E.; Greenlee, H.; Grosso, R.; Guenette, R.; Hackenburg, A.; Hamilton, P.; Hen, O.; Hewes, J.; Hill, C.; Ho, J.; Horton-Smith, G.; Huang, E.-C.; James, C.; de Vries, J. Jan; Jen, C.-M.; Jiang, L.; Johnson, R. A.; Joshi, J.; Jostlein, H.; Kaleko, D.; Karagiorgi, G.; Ketchum, W.; Kirby, B.; Kirby, M.; Kobilarcik, T.; Kreslo, I.; Laube, A.; Li, Y.; Lister, A.; Littlejohn, B. R.; Lockwitz, S.; Lorca, D.; Louis, W. C.; Luethi, M.; Lundberg, B.; Luo, X.; Marchionni, A.; Mariani, C.; Marshall, J.; Martinez Caicedo, D. A.; Meddage, V.; Miceli, T.; Mills, G. B.; Moon, J.; Mooney, M.; Moore, C. D.; Mousseau, J.; Murrells, R.; Naples, D.; Nienaber, P.; Nowak, J.; Palamara, O.; Paolone, V.; Papavassiliou, V.; Pate, S. F.; Pavlovic, Z.; Piasetzky, E.; Porzio, D.; Pulliam, G.; Qian, X.; Raaf, J. L.; Rafique, A.; Rochester, L.; von Rohr, C. Rudolf; Russell, B.; Schmitz, D. W.; Schukraft, A.; Seligman, W.; Shaevitz, M. H.; Sinclair, J.; Snider, E. L.; Soderberg, M.; Söldner-Rembold, S.; Soleti, S. R.; Spentzouris, P.; Spitz, J.; St. John, J.; Strauss, T.; Sutton, K. A.; Szelc, A. M.; Tagg, N.; Terao, K.; Thomson, M.; Toups, M.; Tsai, Y.-T.; Tufanli, S.; Usher, T.; Van de Water, R. G.; Viren, B.; Weber, M.; Wickremasinghe, D. A.; Wolbers, S.; Wongjirad, T.; Woodruff, K.; Yang, T.; Yates, L.; Zeller, G. P.; Zennamo, J.; Zhang, C.

    2017-09-01

    The MicroBooNE liquid argon time projection chamber (LArTPC) has been taking data at Fermilab since 2015 collecting, in addition to neutrino beam, cosmic-ray muons. Results are presented on the reconstruction of Michel electrons produced by the decay at rest of cosmic-ray muons. Michel electrons are abundantly produced in the TPC, and given their well known energy spectrum can be used to study MicroBooNE's detector response to low-energy electrons (electrons with energies up to ~ 50 MeV). We describe the fully-automated algorithm developed to reconstruct Michel electrons, with which a sample of ~ 14,000 Michel electron candidates is obtained. Most of this article is dedicated to studying the impact of radiative photons produced by Michel electrons on the accuracy and resolution of their energy measurement. In this energy range, ionization and bremsstrahlung photon production contribute similarly to electron energy loss in argon, leading to a complex electron topology in the TPC. By profiling the performance of the reconstruction algorithm on simulation we show that the ability to identify and include energy deposited by radiative photons leads to a significant improvement in the energy measurement of low-energy electrons. The fractional energy resolution we measure improves from over 30% to ~ 20% when we attempt to include radiative photons in the reconstruction. These studies are relevant to a large number of analyses which aim to study neutrinos by measuring electrons produced by νe interactions over a broad energy range.

  19. Interspecific territoriality in gibbons (Hylobates lar and H. pileatus) and its effects on the dynamics of interspecies contact zones.

    PubMed

    Suwanvecho, Udomlux; Brockelman, Warren Y

    2012-01-01

    We investigated the ecology and interspecific interactions of the two gibbon species (Hylobates lar and H. pileatus) that overlap in distribution within a narrow zone of contact in the headwaters of the Takhong River at Khao Yai National Park in central Thailand. The zone is about 10-km wide, with phenotypic hybrids comprising 6.5% of the adult population. We compared species with respect to diet, territory size, intra- and interspecific group encounters, and territory quality. The two gibbon species exploited the same types of resources within their territories despite variation in the relative abundance of food-plant species between territories. The gibbons were interspecifically territorial, and males of both species displayed aggressive behaviors at both intraspecific and interspecific territorial boundaries. There was no marked difference in the amount of overlap between territories of conspecific and heterospecific pairs of groups. Although the habitat was not homogeneous, territory quality did not vary significantly between species. The species have not diverged in habitat preference or in diet. Neither species dominated in interspecific encounters, and both were reproducing well in the contact zone. We analyzed the potential consequences of several types of interspecific interactions on individual dispersal options and on the structure of the contact zone. Interference competition through interspecific territoriality affects the dispersal of individuals into the range of the other species. In general, territorial competition coupled with limited hybridization leads to predictions of a narrow contact zone or parapatry between species; thus, behavioral and ecological interactions between species need to be considered as potential factors in explaining range borders of primate species.

  20. Long-term home range use in white-handed gibbons (Hylobates lar) in Khao Yai National Park, Thailand.

    PubMed

    Bartlett, Thad Q; Light, Lydia E O; Brockelman, Warren Y

    2016-02-01

    Ranging behavior is an important element of how nonhuman primates obtain sufficient resources to ensure biological maintenance and reproductive success. As most primates live in permanent social groups, group members must balance the benefits of group living with the costs of intragroup competition for resources. One way to mitigate the cost of intragroup feeding competition is to increase foraging-related travel, thereby increasing the number of patches visited. As a result we might expect home range size to increase as a function of group size. On the other hand, for perennially territorial species, ranging behavior may be constrained by the ranging requirements of territorial defense or by the location of neighboring territories, which would result in long-term stability in the size and location of a group's home range. In this study, we examined changes in range-use characteristics in one well-habituated group of white-handed gibbons (Hylobates lar) during three study periods over a 10-year span. Group size changed from five members, two adults, two juveniles, and one infant, in 1994, to two adults in 2002, and to three adults and one sub-adult in 2004. Despite inter-annual changes in core area use we found that home range location was highly stable across years. Nevertheless, home range size was larger and daily path length significantly longer in 2002 relative to 1994 when a dependent infant was present in the group. The percentage of time adults spent resting was also significantly greater in 1994 when the infant was present. These findings highlight the importance of considering group composition, in addition to group size, when evaluating the determinants of ranging behavior. We also consider the influence of individual and shared knowledge on home range stability. © 2015 Wiley Periodicals, Inc.

  1. Locomotor versatility in the white-handed gibbon (Hylobates lar): a spatiotemporal analysis of the bipedal, tripedal, and quadrupedal gaits.

    PubMed

    Vereecke, Evie E; D'Août, Kristiaan; Aerts, Peter

    2006-05-01

    This study gives a qualitative and quantitative description of the different terrestrial locomotor modes of a group of white-handed gibbons (Hylobates lar) from the Wild Animal Park Planckendael, Belgium. The gibbons were filmed during voluntary locomotion on a grassy and smooth substrate and on a pole. These video images allowed us to define seven different gait types, based on spatial and temporal footfall patterns. Consequent digitization of the video images (n = 254) yielded duty factors, stride lengths, and stride frequencies of the fore- and hind limbs during locomotion at a wide range of speeds. These spatiotemporal gait characteristics were regressed against velocity, and the regression lines of the different gait types were compared. In addition, gibbon bipedalism was compared with bonobo (Pan paniscus) and human bipedalism. Gibbons appear to be very versatile animals, using a bipedal, tripedal, or quadrupedal gait during terrestrial travel with an overlapping speed range. The spatiotemporal characteristics of these gaits are largely similar, although they have clearly distinct footfall patterns. Bipedal walking on the pole is slightly different from terrestrial bipedalism, but differences between substrate types (grass vs. catwalk) are subtle. During bipedalism, gibbons increase both stride length and frequency to increase speed, just as humans and bonobos do, but at a given speed, gibbons take relatively larger strides at lower rates. Bipedal walking in gibbons also appears to be relatively fast-gibbons could keep on walking at speeds where humans have to start running. Apparently, adaptations for arboreal locomotion have not constrained the terrestrial locomotor abilities of gibbons. This may indicate that the step from an arboreal ancestral ape to a terrestrial, upright bipedal hominin might not be difficult and that structural specializations are not a prerequisite for adopting a (non-habitual) bipedal gait.

  2. [Effect of long-term treatment with octreotide-lar in a TSH-secreting pituitary macroadenoma and secondary hyperthyroidism].

    PubMed

    Del Monte, P; Bernasconi, D; Ruelle, A; Marugo, A; Marugo, M; Torre, R

    2005-06-01

    A 74 year-old man was admitted to the hospital for heart failure and atrial fibrillation episodes. He had been irregularly treated for hyperthyroidism during the previous 3 years, with poor control. Thyroid function evaluation showed secondary hyperthyroidism, with high free thyroid hormone levels and TSH inappropriately in the high-normal range (4.2 mU/ml), only slightly responsive to TRH-stimulation (6 microU/ml). Alpha-subunits were hyper-responsive to TRH stimulation (+123%). Thyroid autoimmunity tests were negative and ultrasonography evidenced a diffusely enlarged gland. Magnetic resonance (MR) imaging of the pituitary showed a macroadenoma. The patient underwent transphenoidal adenomectomy, and immunohistochemistry confirmed the diagnosis of a TSH-secreting pituitary macroadenoma. A moderate secondary hyperthyroidism was still present and a new MR evidenced residual disease, involving the right cavernous sinus. A (111)In-octreoscan revealed an increased captation in this area. The patient was treated with octreotide-Lar (20 mg/monthly), which normalized FT3, FT4 and TSH levels already after 3 months of therapy. This effect is still maintained at 42 months of treatment. MR imaging showed a reduction in the residual lesion after 18 months (>50% in comparison with postsurgical MR) and a further decrease after 36 months of treatment). This suggests that the antiproliferative effect on the adenomatous cells is progressive and continues over time. This patients did not receive radiotherapy, so this action is entirely due to the medical treatment. No significant side effects developed and the patient's compliance was good. He has not had further arrhythmic episodes.

  3. Different Alleles of a Gene Encoding Leucoanthocyanidin Reductase (PaLAR3) Influence Resistance against the Fungus Heterobasidion parviporum in Picea abies.

    PubMed

    Nemesio-Gorriz, Miguel; Hammerbacher, Almuth; Ihrmark, Katarina; Källman, Thomas; Olson, Åke; Lascoux, Martin; Stenlid, Jan; Gershenzon, Jonathan; Elfstrand, Malin

    2016-08-01

    Despite the fact that fungal diseases are a growing menace for conifers in modern silviculture, only a very limited number of molecular markers for pathogen resistance have been validated in conifer species. A previous genetic study indicated that the resistance of Norway spruce (Picea abies) to Heterobasidion annosum s.l., a pathogenic basidiomycete species complex, is linked to a quantitative trait loci that associates with differences in fungal growth in sapwood (FGS) that includes a gene, PaLAR3, which encodes a leucoanthocyanidin reductase. In this study, gene sequences showed the presence of two PaLAR3 allelic lineages in P. abies. Higher resistance was associated with the novel allele, which was found in low frequency in the four P. abies populations that we studied. Norway spruce plants carrying at least one copy of the novel allele showed a significant reduction in FGS after inoculation with Heterobasidion parviporum compared to their half-siblings carrying no copies, indicating dominance of this allele. The amount of (+) catechin, the enzymatic product of PaLAR3, was significantly higher in bark of trees homozygous for the novel allele. Although we observed that the in vitro activities of the enzymes encoded by the two alleles were similar, we could show that allele-specific transcript levels were significantly higher for the novel allele, indicating that regulation of gene expression is responsible for the observed effects in resistance, possibly caused by differences in cis-acting elements that we observe in the promoter region of the two alleles.

  4. Numerical modeling of the simulated gas hydrate production test at Mallik 2L-38 in the pilot scale pressure reservoir LARS - Applying the "foamy oil" model

    NASA Astrophysics Data System (ADS)

    Abendroth, Sven; Thaler, Jan; Klump, Jens; Schicks, Judith; Uddin, Mafiz

    2014-05-01

    In the context of the German joint project SUGAR (Submarine Gas Hydrate Reservoirs: exploration, extraction and transport) we conducted a series of experiments in the LArge Reservoir Simulator (LARS) at the German Research Centre of Geosciences Potsdam. These experiments allow us to investigate the formation and dissociation of hydrates at large scale laboratory conditions. We performed an experiment similar to the field-test conditions of the production test in the Mallik gas hydrate field (Mallik 2L-38) in the Beaufort Mackenzie Delta of the Canadian Arctic. The aim of this experiment was to study the transport behavior of fluids in gas hydrate reservoirs during depressurization (see also Heeschen et al. and Priegnitz et al., this volume). The experimental results from LARS are used to provide details about processes inside the pressure vessel, to validate the models through history matching, and to feed back into the design of future experiments. In experiments in LARS the amount of methane produced from gas hydrates was much lower than expected. Previously published models predict a methane production rate higher than the one observed in experiments and field studies (Uddin et al. 2010; Wright et al. 2011). The authors of the aforementioned studies point out that the current modeling approach overestimates the gas production rate when modeling gas production by depressurization. They suggest that trapping of gas bubbles inside the porous medium is responsible for the reduced gas production rate. They point out that this behavior of multi-phase flow is not well explained by a "residual oil" model, but rather resembles a "foamy oil" model. Our study applies Uddin's (2010) "foamy oil" model and combines it with history matches of our experiments in LARS. Our results indicate a better agreement between experimental and model results when using the "foamy oil" model instead of conventional models of gas flow in water. References Uddin M., Wright J.F. and Coombe D

  5. Change in quality of life in patients with acromegaly after treatment with octreotide LAR: first application of AcroQoL in Korea

    PubMed Central

    Chin, Sang Ouk; Chung, Choon Hee; Chung, Yoon-Sok; Kim, Byung-Joon; Kim, Hee Young; Kim, In-Ju; Kim, Jung Guk; Kim, Min-Seon; Kim, Seong-Yeon; Lee, Eun Jig; Lee, Ki Young; Kim, Sung-Woon

    2015-01-01

    Objectives This study was designed to investigate changes in health-related quality of life (HRQoL) of patients with acromegaly in Korea after medical treatment with octreotide LAR using the validated Korean version of the acromegaly quality of life questionnaire (AcroQoL). Design A prospective, open-label, single-arm study. Setting 11 tertiary centres in Korea. Participants 58 Korean patients (aged 21–72 years) who were newly diagnosed with acromegaly between 2009 and 2012 were prescribed octreotide LAR 20 mg at the time of enrolment. During 24 weeks of observation, AcroQoL survey questionnaires and measurement of growth hormone insulin-like growth factor 1(GH/IGF-I) were performed at baseline, week 12 and week 24. Main outcome measures We assessed the HRQoL of Korean patients with acromegaly after medical treatment with octreotide LAR using the validated Korean version of the AcroQoL questionnaire. Results Patients had a mean age of 47.2 years (29 males), and GH and IGF-I significantly decreased during the first 12 weeks (GH: 4.8 vs 1.9 μg/L, p<0.001; IGF-I: 497 vs 265 μg/L, p<0.001), but showed insignificant change at week 24 (GH: 2.3 μg/L; IGF-I: 294 μg/L). Only AcroQoL scores for the psychological appearance subdomain showed a significant increase during the entire 24 weeks (p<0.05). The change in the psychological appearance subdomain of AcroQoL scores demonstrated a significant but weak negative correlation with change in IGF-I levels (r=−0.282, p=0.039). When patients were divided into two groups according to their disease activity at week 24 (controlled vs uncontrolled), there was no difference in AcroQoL scores, but the psychological appearance subdomain of the two groups appeared to change differently over the entire 24-week period (p=0.047). Conclusions: Medical treatment with octreotide LAR in patients with acromegaly has a limited contribution to HRQoL as assessed by the AcroQoL. PMID:26063564

  6. Case study of a 15-year-old boy with McCune-Albright syndrome combined with pituitary gigantism: effect of octreotide-long acting release (LAR) and cabergoline therapy.

    PubMed

    Tajima, Toshihiro; Tsubaki, Junko; Ishizu, Katsura; Jo, Wakako; Ishi, Nobuaki; Fujieda, Kenji

    2008-07-01

    The use of octreotide-LAR and cabergoline therapy has shown great promise in adults with acromegaly; however, the experience in pediatric patients has rarely been reported. We described a clinical course of a 15-year-old boy of McCune-Albright syndrome (MAS) with pituitary gigantism. At the age of 8 years, a growth hormone (GH) and prolactin (PRL) producing pituitary adenoma was diagnosed at our hospital. He also had multiple fibrous dysplasia, so that he was diagnosed as having MAS. The tumor was partially resected, and GNAS1 gene mutation (R201C) was identified in affected tissues. We introduced octreotide to suppress GH secretion (100 mug 2/day s.c). During therapy with octreotide, IGF-1 and GH levels could not be suppressed and the patient frequently complained of nausea from octreotide treatment. Therefore, the therapy was changed to monthly injections of octreotide-LAR at the age of 12.3 years and was partially effective. However, as defect of left visual field worsened due to progressive left optic canal stenosis, he underwent second neurological decompression of the left optic nerve at 13.4 years of age. After surgery, in addition to octreotide-LAR, cabergoline (0.25 mg twice a month) was started. This regimen normalized serum levels of GH and IGF-1; however, he showed impaired glucose tolerance and gallstones at 15.7 years of age. Therefore, the dose of octreotide-LAR was reduced to 10 mg and the dose of cabergoline increased. This case demonstrated the difficulty of treating pituitary gigantism due to MAS. The use of octreotide-LAR and cabergoline should be considered even in pediatric patients; however, adverse events due to octreotide-LAR must be carefully examined.

  7. Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group.

    PubMed

    Rinke, Anja; Müller, Hans-Helge; Schade-Brittinger, Carmen; Klose, Klaus-Jochen; Barth, Peter; Wied, Matthias; Mayer, Christina; Aminossadati, Behnaz; Pape, Ulrich-Frank; Bläker, Michael; Harder, Jan; Arnold, Christian; Gress, Thomas; Arnold, Rudolf

    2009-10-01

    Somatostatin analogs are indicated for symptom control in patients with gastroenteropancreatic neuroendocrine tumors (NETs). The ability of somatostatin analogs to control the growth of well-differentiated metastatic NETs is a matter of debate. We performed a placebo-controlled, double-blind, phase IIIB study in patients with well-differentiated metastatic midgut NETs. The hypothesis was that octreotide LAR prolongs time to tumor progression and survival. Treatment-naive patients were randomly assigned to either placebo or octreotide LAR 30 mg intramuscularly in monthly intervals until tumor progression or death. The primary efficacy end point was time to tumor progression. Secondary end points were survival time and tumor response. This report is based on 67 tumor progressions and 16 observed deaths in 85 patients at the time of the planned interim analysis. Median time to tumor progression in the octreotide LAR and placebo groups was 14.3 and 6 months, respectively (hazard ratio [HR] = 0.34; 95% CI, 0.20 to 0.59; P = .000072). After 6 months of treatment, stable disease was observed in 66.7% of patients in the octreotide LAR group and 37.2% of patients in the placebo group. Functionally active and inactive tumors responded similarly. The most favorable effect was observed in patients with low hepatic tumor load and resected primary tumor. Seven and nine deaths were observed in the octreotide LAR and placebo groups, respectively. The HR for overall survival was 0.81 (95% CI, 0.30 to 2.18). Octreotide LAR significantly lengthens time to tumor progression compared with placebo in patients with functionally active and inactive metastatic midgut NETs. Because of the low number of observed deaths, survival analysis was not confirmatory.

  8. Exclusive muon neutrino charged current pion-less topologies. ArgoNeuT results and future prospects in LAr TPC detectors

    SciTech Connect

    Palamara, Ornella

    2016-12-29

    Results from the analysis of charged current pion-less (CC 0-pion) muon neutrino events in argon collected by the ArgoNeuT experiment on the NuMI beam at Fermilab are presented and compared with predictions from Monte Carlo simulations. A novel analysis method, based on the reconstruction of exclusive topologies, fully exploiting the Liquid argon Time Projection Chamber (LAr TPC) technique capabilities, is used to analyze the events, characterized by the presence at the vertex of a leading muon track eventually accompanied by one or more highly ionizing tracks, and study nuclear effects in neutrino interactions on argon nuclei. Multiple protons accompanying the leading muon are visible in the ArgoNeuT events, and measured with a proton reconstruction threshold of 21 MeV kinetic energy. As a result, measurements of (anti-)neutrino CC 0-pion inclusive and exclusive cross sections on argon nuclei are reported. Prospects for future, larger mass LAr TPC detectors are discussed.

  9. Exclusive muon neutrino charged current pion-less topologies. ArgoNeuT results and future prospects in LAr TPC detectors

    DOE PAGES

    Palamara, Ornella

    2016-12-29

    Results from the analysis of charged current pion-less (CC 0-pion) muon neutrino events in argon collected by the ArgoNeuT experiment on the NuMI beam at Fermilab are presented and compared with predictions from Monte Carlo simulations. A novel analysis method, based on the reconstruction of exclusive topologies, fully exploiting the Liquid argon Time Projection Chamber (LAr TPC) technique capabilities, is used to analyze the events, characterized by the presence at the vertex of a leading muon track eventually accompanied by one or more highly ionizing tracks, and study nuclear effects in neutrino interactions on argon nuclei. Multiple protons accompanying themore » leading muon are visible in the ArgoNeuT events, and measured with a proton reconstruction threshold of 21 MeV kinetic energy. As a result, measurements of (anti-)neutrino CC 0-pion inclusive and exclusive cross sections on argon nuclei are reported. Prospects for future, larger mass LAr TPC detectors are discussed.« less

  10. A comparison of acute and chronic anterior cruciate ligament reconstruction using LARS artificial ligaments: a randomized prospective study with a 5-year follow-up.

    PubMed

    Chen, Jia; Gu, Aiqun; Jiang, Haitao; Zhang, Wenjie; Yu, Xiangrong

    2015-01-01

    This prospective randomized study compared acute and chronic anterior cruciate ligament (ACL) reconstruction using ligament advanced reinforcement system (LARS) artificial ligament in young active adults with a 5-year follow-up. Fifty-five patients were enrolled in this study and divided into two groups based on the elapsed time between the injury and reconstruction: the acute group (3-7 weeks) and the chronic group (6-11 months). The clinical outcomes were evaluated using the Lysholm knee scoring scale, the Tegner activity rating, a KT-1000 Arthrometer, and the International Knee Documentation Committee (IKDC) scoring system. Isokinetic strength of the quadriceps and hamstring was assessed using the Biodex System 3 isokinetic dynamometer. Anterior laxity was decreased and quadriceps/hamstring muscle strength was increased in the acute group compared to the chronic group (p > 0.05). There were no statistically significant differences in Lysholm scores, Tegner activity scores, and the IKDC evaluation form between the two groups. These results suggest that earlier ACL reconstruction using a LARS artificial ligament may provide an advantage in the treatment and rehabilitation of ACL rupture.

  11. The Drosophila Receptor Protein Tyrosine Phosphatase LAR Is Required for Development of Circadian Pacemaker Neuron Processes That Support Rhythmic Activity in Constant Darkness But Not during Light/Dark Cycles

    PubMed Central

    Agrawal, Parul

    2016-01-01

    In Drosophila, a transcriptional feedback loop that is activated by CLOCK-CYCLE (CLK-CYC) complexes and repressed by PERIOD-TIMELESS (PER-TIM) complexes keeps circadian time. The timing of CLK-CYC activation and PER-TIM repression is regulated post-translationally, in part through rhythmic phosphorylation of CLK, PER, and TIM. Although kinases that control PER, TIM, and CLK levels, activity, and/or subcellular localization have been identified, less is known about phosphatases that control clock protein dephosphorylation. To identify clock-relevant phosphatases, clock-cell-specific RNAi knockdowns of Drosophila phosphatases were screened for altered activity rhythms. One phosphatase that was identified, the receptor protein tyrosine phosphatase leukocyte-antigen-related (LAR), abolished activity rhythms in constant darkness (DD) without disrupting the timekeeping mechanism in brain pacemaker neurons. However, expression of the neuropeptide pigment-dispersing factor (PDF), which mediates pacemaker neuron synchrony and output, is eliminated in the dorsal projections from small ventral lateral (sLNv) pacemaker neurons when Lar expression is knocked down during development, but not in adults. Loss of Lar function eliminates sLNv dorsal projections, but PDF expression persists in sLNv and large ventral lateral neuron cell bodies and their remaining projections. In contrast to the defects in lights-on and lights-off anticipatory activity seen in flies that lack PDF, Lar RNAi knockdown flies anticipate the lights-on and lights-off transition normally. Our results demonstrate that Lar is required for sLNv dorsal projection development and suggest that PDF expression in LNv cell bodies and their remaining projections mediate anticipation of the lights-on and lights-off transitions during a light/dark cycle. SIGNIFICANCE STATEMENT In animals, circadian clocks drive daily rhythms in physiology, metabolism, and behavior via transcriptional feedback loops. Because key circadian

  12. Gibbons (Hylobates pileatus, H. moloch, H. lar, Symphalangus syndactylus) follow human gaze, but do not take the visual perspective of others.

    PubMed

    Liebal, Katja; Kaminski, Juliane

    2012-11-01

    We investigated four gibbon species of two different genera (Hylobates pileatus, H. moloch, H. lar, Symphalangus syndactylus) in terms of their looking behavior in response to a human who either looked up or looked at the gibbon. Comparing those two conditions, gibbons as a group looked up more when the human was looking up, but they also performed more looks in other directions and thus generally looked more in this condition. Unlike great apes, gibbons did not respond differently between conditions when only the first look on every trial was considered. Furthermore, they did not perform double looks up to check where the human was looking and also did not habituate to the human's looks up. This suggests that gibbons co-orient with human gaze, but unlike great apes, they do not take the visual perspective of others.

  13. Placebo-Controlled, Double-Blind, Prospective, Randomized Study on the Effect of Octreotide LAR in the Control of Tumor Growth in Patients with Metastatic Neuroendocrine Midgut Tumors (PROMID): Results of Long-Term Survival.

    PubMed

    Rinke, Anja; Wittenberg, Michael; Schade-Brittinger, Carmen; Aminossadati, Behnaz; Ronicke, Erdmuthe; Gress, Thomas M; Müller, Hans-Helge; Arnold, Rudolf

    2017-01-01

    Somatostatin analogs have been shown to control the growth of well-differentiated metastatic neuroendocrine tumors. Their effect on overall survival is a matter of debate. We analyzed the prognostic significance of early treatment with octreotide LAR and of hepatic tumor load in the PROMID trial cohort. Between 2001 and 2008, 85 treatment-naïve patients were randomly assigned to monthly octreotide LAR 30 mg or placebo until tumor progression or death. Post-study treatment was at the discretion of the investigator. Upon disease progression, 38 out of 43 placebo patients (88.4%) received octreotide LAR. For survival, patients were followed until May 2014. Forty-eight out of 85 patients (56.5%) died. In 38 patients (79.2%), death was tumor related. The median overall survival (84.7 and 83.7 months) was only slightly different in patients assigned to octreotide and placebo [HR = 0.83 (95% CI: 0.47-1.46); p = 0.51]. The median overall survival was 84.7 months for all 85 patients, 107.6 months in the low-tumor-load (n = 64) and 57.5 months in the high-tumor-load (n = 21) subgroups [HR = 2.49 (95% CI: 1.36-4.55); p = 0.002]. There was a trend towards improved overall survival in patients with a low hepatic tumor load receiving octreotide compared to placebo ['median not reached' and 87.2 months; HR = 0.59 (95% CI: 0.29-1.2); p = 0.142]. The extent of tumor burden is a predictor for shorter survival. Overall survival was similar in patients receiving octreotide LAR or placebo treatment at randomization. Crossover of the majority of placebo patients to octreotide LAR may have confounded the data on overall survival. © 2016 S. Karger AG, Basel.

  14. Transmembrane proteins UNC-40/DCC, PTP-3/LAR, and MIG-21 control anterior-posterior neuroblast migration with left-right functional asymmetry in Caenorhabditis elegans.

    PubMed

    Sundararajan, Lakshmi; Lundquist, Erik A

    2012-12-01

    Migration of neurons and neural crest cells is of central importance to the development of nervous systems. In Caenorhabditis elegans, the QL neuroblast on the left migrates posteriorly, and QR on the right migrates anteriorly, despite similar lineages and birth positions with regard to the left-right axis. Initial migration is independent of a Wnt signal that controls later anterior-posterior Q descendant migration. Previous studies showed that the transmembrane proteins UNC-40/DCC and MIG-21, a novel thrombospondin type I repeat containing protein, act redundantly in left-side QL posterior migration. Here we show that the LAR receptor protein tyrosine phosphatase PTP-3 acts with MIG-21 in parallel to UNC-40 in QL posterior migration. We also show that in right-side QR, the UNC-40 and PTP-3/MIG-21 pathways mutually inhibit each other's role in posterior migration, allowing anterior QR migration. Finally, we present evidence that these proteins act autonomously in the Q neuroblasts. These studies indicate an inherent left-right asymmetry in the Q neuroblasts with regard to UNC-40, PTP-3, and MIG-21 function that results in posterior vs. anterior migration.

  15. Transmembrane Proteins UNC-40/DCC, PTP-3/LAR, and MIG-21 Control Anterior–Posterior Neuroblast Migration with Left–Right Functional Asymmetry in Caenorhabditis elegans

    PubMed Central

    Sundararajan, Lakshmi; Lundquist, Erik A.

    2012-01-01

    Migration of neurons and neural crest cells is of central importance to the development of nervous systems. In Caenorhabditis elegans, the QL neuroblast on the left migrates posteriorly, and QR on the right migrates anteriorly, despite similar lineages and birth positions with regard to the left–right axis. Initial migration is independent of a Wnt signal that controls later anterior–posterior Q descendant migration. Previous studies showed that the transmembrane proteins UNC-40/DCC and MIG-21, a novel thrombospondin type I repeat containing protein, act redundantly in left-side QL posterior migration. Here we show that the LAR receptor protein tyrosine phosphatase PTP-3 acts with MIG-21 in parallel to UNC-40 in QL posterior migration. We also show that in right-side QR, the UNC-40 and PTP-3/MIG-21 pathways mutually inhibit each other’s role in posterior migration, allowing anterior QR migration. Finally, we present evidence that these proteins act autonomously in the Q neuroblasts. These studies indicate an inherent left–right asymmetry in the Q neuroblasts with regard to UNC-40, PTP-3, and MIG-21 function that results in posterior vs. anterior migration. PMID:23051647

  16. Home-range characteristics and the influence of seasonality on female reproduction in white-handed gibbons (Hylobates lar) at Khao Yai National Park, Thailand.

    PubMed

    Savini, Tommaso; Boesch, Christophe; Reichard, Ulrich H

    2008-01-01

    A three-year (2001-2003) study was carried out on the home range characteristics of seven wild white-handed gibbon (Hylobates lar) groups focusing on the spatio-temporal distribution of food resources at Khao Yai National Park in northeastern Thailand. These results were combined with 23 years (1980-2003) of reproductive performance data on seven females from the same focal groups. Reproductive performance was equal among females with regard to birth, weaning and maturation ratios, and independent of variation in food availability. Offspring mortality, however, was significantly positively correlated with home-range size. In addition, there was an increase in offspring mortality just after weaning, suggesting that the increase in the daily distance traveled by juveniles contributed to this mortality. Conceptions clustered during the first half of the year when food production was at its peak, which presumably allowed females to accumulate sufficient body reserves to resume ovarian cycling. Our results place Khao Yai gibbons closer to Cercopithecidae than great apes in terms of the temporal pattern of reproductive events, though gestation, lactation, inter-birth interval, and offspring maturation are considerably longer in gibbons, placing them closer to the other apes. Our findings underline the unique phylogenetic position of these small-bodied apes in terms of reproductive patterns in primates. (c) 2007 Wiley-Liss, Inc.

  17. First operation and performance of a 200 lt double phase LAr LEM-TPC with a 40 × 76 cm2 readout

    NASA Astrophysics Data System (ADS)

    Badertscher, A.; Curioni, A.; Degunda, U.; Epprecht, L.; Gendotti, A.; Horikawa, S.; Knecht, L.; Lussi, D.; Natterer, G.; Nguyen, K.; Resnati, F.; Rubbia, A.; Viant, T.

    2013-04-01

    In this paper we describe the design, construction, and operation of a first large area double-phase liquid argon Large Electron Multiplier Time Projection Chamber (LAr LEM-TPC). The detector has a maximum drift length of 60 cm and the readout consists of a 40 × 76 cm2 LEM and 2D projective anode to multiply and collect drifting charges. Scintillation light is detected by means of cryogenic PMTs positioned below the cathode. To record both charge and light signals, we have developed a compact acquisition system, which is scalable up to ton-scale detectors with thousands of charge readout channels. The acquisition system, as well as the design and the performance of custom-made charge sensitive preamplifiers, are described. The complete experimental setup has been operated for a first time during a period of four weeks at CERN in the cryostat of the ArDM experiment, which was equipped with liquid and gas argon purification systems. The detector, exposed to cosmic rays, recorded events with a single-channel signal-to-noise ratio in excess of 30 for minimum ionising particles. Cosmic muon tracks and their δ-rays were used to assess the performance of the detector, and to estimate the liquid argon purity and the gain at different amplification fields.

  18. Long-term operation of a double phase LAr LEM Time Projection Chamber with a simplified anode and extraction-grid design

    NASA Astrophysics Data System (ADS)

    Cantini, C.; Epprecht, L.; Gendotti, A.; Horikawa, S.; Murphy, S.; Natterer, G.; Periale, L.; Resnati, F.; Rubbia, A.; Sergiampietri, F.; Viant, T.; Wu, S.

    2014-03-01

    We report on the successful operation of a double phase Liquid Argon Large Electron Multiplier Time Projection Chamber (LAr LEM-TPC) equipped with two dimensional projective anodes with dimensions 10 × 10 cm2, and with a maximum drift length of 21 cm. The anodes were manufactured for the first time from a single multilayer printed circuit board (PCB). Various layouts of the readout views have been tested and optimised. In addition, the ionisation charge was efficiently extracted from the liquid to the gas phase with a single grid instead of two previously. We studied the response and the gain of the detector to cosmic muon tracks. To study long-term stability over several weeks, we continuously operated the chamber at fixed electric field settings. We reproducibly observe that after an initial decrease with a characteristic time of τ ≈ 1.6 days, the observed gain is stable. In 46 days of operation, a total of 14.6 million triggers have been collected at a stable effective gain of G∞ ~ 15 corresponding to a signal-to-noise ratio (S/N)gtrsim60 for minimum ionising tracks. During the full period, eight discharges across the LEM were observed. A maximum effective gain of 90 was also observed, corresponding to a signal-to-noise ratio (S/N)gtrsim400 for minimum ionising tracks, or S/N ≈ 10 for an energy deposition of 15 keV on a single readout channel.

  19. Efficacy of a slow-release formulation of lanreotide (Autogel) 120 mg) in patients with acromegaly previously treated with octreotide long acting release (LAR): an open, multicentre longitudinal study.

    PubMed

    Ronchi, C L; Boschetti, M; Degli Uberti, E C; Mariotti, S; Grottoli, S; Loli, P; Lombardi, G; Tamburrano, G; Arvigo, M; Angeletti, G; Boscani, P F; Beck-Peccoz, P; Arosio, M

    2007-10-01

    Lanreotide Autogel 120 mg (ATG120; Ipsen S.p.A, Milan, Italy) is a high-dose, sustained-release aqueous gel formulation, supplied in a prefilled syringe and given by deep subcutaneous injection. The aim of this study was to compare efficacy and tolerability of ATG120 given every 4-8 weeks with those of octreotide LAR (o-LAR) given every 4 weeks. DESIGN PATIENTS AND INTERVENTION: A phase III multicentre Italian open clinical study of 23 acromegalic patients (15 female, 8 male). All patients had received o-LAR for 6-18 months and, after 3 months wash out, ATG120 was given every 6 weeks for a total of four injections (Period 1). Then the interval between ATG120 injections was adjusted according to three different schemes: every 4, 6 or 8 weeks depending on GH levels (GH > 2.5 microg/l; 1 < GH LAR. The number of patients who achieved GH < 2.5 microg/l was comparable between o-LAR (43%) and ATG120 at Period 1 (48%) and at Period 2 (62%). Normal IGF-I levels were recorded in 8 patients during o-LAR (35%), 11 during ATG Period 1 (48%) and 10 at the final visit (43%). Last, 4 patients showed a better response to ATG

  20. Leaf swallowing and parasite expulsion in Khao Yai white-handed gibbons (Hylobates lar), the first report in an Asian ape species.

    PubMed

    Barelli, Claudia; Huffman, Michael A

    2017-03-01

    Leaf swallowing behavior, known as a form of self-medication for the control of nematode and tapeworm infection, occurs widely in all the African great apes (Pan troglodytes schweinfurthii, P. t. troglodytes, P. t. verus, P. t. vellerosus, Pan paniscus, Gorilla gorilla graueri), except mountain gorillas. It is also reported to occur in a similar context across a wide array of other animal taxa including, domestic dogs, wolves, brown bears, and civets. Despite long-term research on Asian great and small apes, this is the first report of leaf swallowing in an Asian species, the white-handed gibbon (Hylobates lar) in Khao Yai National Park, central Thailand. We present the first evidence of leaf swallowing (Gironniera nervosa Planch CANNABACEA) behavior (N = 5 cases) and parasite (Streptopharagus pigmentatus) expulsion (N = 4 cases), recorded during 4,300 hr of direct animal observations during two distinct research projects. We recovered 4-18 rough, hairy, and hispid surfaced leaves from each sample, undigested and folded, from the freshly evacuated feces of five different individuals (2 males, 3 females, 5 to 34+ years old) living in three different social groups, between the hours of 06:00 to 10:30. Based on close inspection of the leaves, as observed in chimpanzees, it was clear that they were taken into the mouth, one at a time, folded and detached from the stem with the teeth before swallowing them whole. All instances occurred during the rainy season, the time when nematode worms were also found in the feces, although they were not found together with leaves in the same feces. These striking similarities in the details of leaf swallowing between white-handed gibbons and African great apes, and other animal species, suggest a similar self-medicative function. © 2016 Wiley Periodicals, Inc.

  1. In vivo and in vitro response to octreotide LAR in a TSH-secreting adenoma: characterization of somatostatin receptor expression and role of subtype 5.

    PubMed

    Gatto, Federico; Barbieri, Federica; Castelletti, Lara; Arvigo, Marica; Pattarozzi, Alessandra; Annunziata, Francesca; Saveanu, Alexandru; Minuto, Francesco; Castellan, Lucio; Zona, Gianluigi; Florio, Tullio; Ferone, Diego

    2011-06-01

    Thyrotropin-secreting pituitary adenomas (TSHomas) are a rare cause of hyperthyroidism and account for less than 2% of pituitary adenomas. Medical therapy with somatostatin analogues (SSAs) effectively reduces TSH secretion in approximately 80% of patients and induces shrinkage in about 45% of tumors. According with previous data, resistance to SSA treatment might be due to heterogeneity in somatostatin receptors (SSTRs) expression. We report the case of TSHoma in a 41-year-old man treated with octreotide LAR that caused a dramatic decrease of TSH and thyroid hormones and tumor shrinkage already after 3 months of pre-surgical therapy. In search of potential molecular determinants of octreotide effectiveness, we measured, in primary cultures from this tumor, SSTR and dopamine D2 receptor (D2R) expression, and octreotide and/or cabergoline effects on TSH secretion and cell proliferation. SSTR5 and D2R expression was higher than SSTR2. Octreotide significantly inhibited TSH secretion more effectively than cabergoline (P<0.001), whereas the combined treatment was comparable with cabergoline alone. Similarly, octreotide resulted more effective than cabergoline on cell proliferation, while the combination did not show any additive or synergistic effects. In conclusion, the significant antisecretive and antiproliferative effect of octreotide in this patient might be related to the high expression of SSTR5, in the presence of SSTR2. After reviewing the literature, indeed, in line with previous observations, we hypothesize that SSTR5/SSTR2 ratio in TSHomas may represent a useful marker in predicting the outcome of therapy with SSAs. The role of D2R should be further explored considering that the presence of D2R can influence SSTRs functionality. © Springer Science+Business Media, LLC 2010

  2. Path Crossings with Lars Onsager

    NASA Astrophysics Data System (ADS)

    Yang, Chen Ning

    2013-05-01

    I first heard of Onsager's name from my M.S. degree thesis adviser J. S. Wang in Kunming, China. Wang had studied the theory of order-disorder transitions with R. H. Fowler in Cambridge, England in the 1930's. He told me one day in 1944-45 that Onsager had produced an exact solution of the Ising model in two dimensions. Wang was a quiet and reserved person. But that day he was evidently quite excited. I can remember still today, half a century later, the tone of admiration bordering on agitation with which he told me about Onsager's paper. I then looked up the paper [26J, but did not understand the strategic plan of Onsager's method. Onsager seemed to have a predilection for calculating commutators at every possible turn without supplying the reasons for so doing...

  3. Rationale and protocol of the MetNET-1 trial, a prospective, single center, phase II study to evaluate the activity and safety of everolimus in combination with octreotide LAR and metformin in patients with advanced pancreatic neuroendocrine tumors.

    PubMed

    Pusceddu, Sara; de Braud, Filippo; Concas, Laura; Bregant, Cristina; Leuzzi, Livia; Formisano, Barbara; Buzzoni, Roberto

    2014-01-01

    Abnormal PI3K-AKT-mTOR pathway signalling and autocrine activation of the mTOR pathway, mediated through insulin-like growth factor-1, have been implicated in the proliferation of pancreatic neuroendocrine tumor (pNET) cells. Everolimus, an mTOR inhibitor, has shown antitumor benefit in pNETs alone and in combination with octreotide LAR in RADIANT-1 and RADIANT-3 studies. Although everolimus-based phase II/III trials have improved progression-free survival for pNET, its use has not impacted on prolonging overall survival. Metformin has recently shown some anti-cancer activity in both in vitro and in vivo studies by its indirect properties to decrease insulin and insulin-like growth factor-1 (IGF-1) levels and by its antitumour effect to promote AMPK activation and consequently inhibition to TSC1-2/mTOR complex. In light of even more retrospective evidence of metformin's anticancer activity, a prospective evaluation is required to either confirm or discard these preliminary findings. With the aim to evaluate the antiproliferative effect of metformin in combination with everolimus and octreotide LAR in pancreatic well-differentiated neuroendocrine tumor patients, a single arm, prospective, single center phase II study was designed (MetNET-1 trial, NCT 02294006). Forty-three patients are expected to be evaluated. The study is ongoing, and recruitment is estimated to be completed in August 2016. The results will be anticipated in 2017.

  4. Detailed geomorphological mapping of debris-covered and rock glaciers in the Hólar area, Tröllaskagi Peninsula (northern Iceland).

    NASA Astrophysics Data System (ADS)

    Tanarro, Luis M.; Palacios, David; Zamorano, Jose J.; Andres, Nuria

    2017-04-01

    Most studies conducted on rock and debris-covered glaciers only include simplified geomorphological maps representing main units (ridges, furrows, front, and thermokarst depressions). The aim of this study is to develop a detailed geomorphological mapping of the Hóladalsjökull debris-covered glacier (65°42' N; 18°57' W) and the Fremri-Grjótárdalur rock glacier (65°43' N 19° W), located near Hólar, a village in the central area of the Trolläskagi peninsula (northern Iceland). The mapping process has been conducted using standard stereo-photointerpretation of aerial photographs and stereo-plotting of a topographic map at 1:2000 scale. Also, landforms have been represented in different transects. Lastly, the geomorphological map has been designed using the elevation digital model, and a 3D pdf file has been generated, allowing for better viewing and understanding the different units and their modelling. The geomorphological mapping of the Hóladalsjökull debris-covered glacier and the Fremri-Grjótárdalur rock glacier represents the prominent walls of their valley heads and their summits, which form a flat highland at 1,200-1,330 metres above sea level, covered by blockfield and patterned ground features. Rockfall and slide landforms are common processes at the foot of these 100-170 metre-high cirque-walls. Debris-covered glaciers and rock glaciers are born right under these walls, building up a spoon-shaped hollow around glacial ice, surrounded by young moraine ridges at their fronts. The dominant features in the Hóladalsjökull debris-covered glacier are large longitudinal ridges and furrows, stretching over 1.5 km in length in the central and western areas. Medium-sized thermokarst depressions (between 15-40 metres in diameter), often running parallel to the furrows, dot the surface of the debris-covered glacier. Parallel alternate ridges and furrows can be seen near the snout. Ridges are rugged and fall around 30-40 metres, with over 30 degree slopes

  5. The Drosophila Receptor Protein Tyrosine Phosphatase LAR Is Required for Development of Circadian Pacemaker Neuron Processes That Support Rhythmic Activity in Constant Darkness But Not during Light/Dark Cycles.

    PubMed

    Agrawal, Parul; Hardin, Paul E

    2016-03-30

    InDrosophila, a transcriptional feedback loop that is activated by CLOCK-CYCLE (CLK-CYC) complexes and repressed by PERIOD-TIMELESS (PER-TIM) complexes keeps circadian time. The timing of CLK-CYC activation and PER-TIM repression is regulated post-translationally, in part through rhythmic phosphorylation of CLK, PER, and TIM. Although kinases that control PER, TIM, and CLK levels, activity, and/or subcellular localization have been identified, less is known about phosphatases that control clock protein dephosphorylation. To identify clock-relevant phosphatases, clock-cell-specific RNAi knockdowns ofDrosophilaphosphatases were screened for altered activity rhythms. One phosphatase that was identified, the receptor protein tyrosine phosphatase leukocyte-antigen-related (LAR), abolished activity rhythms in constant darkness (DD) without disrupting the timekeeping mechanism in brain pacemaker neurons. However, expression of the neuropeptide pigment-dispersing factor (PDF), which mediates pacemaker neuron synchrony and output, is eliminated in the dorsal projections from small ventral lateral (sLNv) pacemaker neurons whenLarexpression is knocked down during development, but not in adults. Loss ofLarfunction eliminates sLNvdorsal projections, but PDF expression persists in sLNvand large ventral lateral neuron cell bodies and their remaining projections. In contrast to the defects in lights-on and lights-off anticipatory activity seen in flies that lack PDF,LarRNAi knockdown flies anticipate the lights-on and lights-off transition normally. Our results demonstrate thatLaris required for sLNvdorsal projection development and suggest that PDF expression in LNvcell bodies and their remaining projections mediate anticipation of the lights-on and lights-off transitions during a light/dark cycle. In animals, circadian clocks drive daily rhythms in physiology, metabolism, and behavior via transcriptional feedback loops. Because key circadian transcriptional activators and

  6. Myers-Briggs Type Indicator Applied to Executive Leadership

    DTIC Science & Technology

    1987-01-01

    Extraversion(E) versus Introversion(I) Sensing (S) versus Intuition(N) Thinking(T) versus Feeling (F) Perception (P) versus Judgment(J) Table 1...Introversion(I) Sensing (S) versus Intuition(N) Thinking(T) versus Feeling (F) Perception (P) versus Judgment(J) Table 1: Preference Scales During Dr... Feeling (F) Perception (P) versus Judgment(J) Table 1: Preference Scales An expanded discussion of the MBTI can be found at Appendix A; however, a

  7. Myers-Briggs Type Indicator: A Cultural and Ethical Evaluation

    DTIC Science & Technology

    1993-04-01

    on the personality theory of Carl Gustav Jung . Jung included three variables in his theory to explain the way people perceive, interpret, and respond...34 Journal of Psychological Type 14 (1988): 15-24. Moore, Thomas. "Personality Tests Are Back; the Latest Management Tool Dates to Carl Jung ." Fortune 30...across 8 a very broad range of life events. Jung believed he was describing mental processes common to the entire human species. To the extent that he

  8. When 'Sanctity of Life' and 'Self-Determination' clash: Briggs versus Briggs [2016] EWCOP 53 - implications for policy and practice.

    PubMed

    Kitzinger, Jenny; Kitzinger, Celia; Cowley, Jakki

    2017-07-01

    In a landmark judgment in the English Court of Protection, the judge (Charles J) found it to be in the best interests of a minimally conscious patient for clinically assisted nutrition and hydration (CANH) to be withdrawn, with the inevitable consequence that the patient would die. In making this judgment, it was accepted that the patient's level of consciousness - if CANH were continued and rehabilitation provided - might improve, and that he might become capable of expressing emotions and making simple choices. The decision to withdraw treatment relied on a best interests decision, which gave great weight to the patient's past wishes, feelings, values and beliefs, and brought a 'holistic' approach to understanding what this particular patient would have wanted. We draw on our own experience of supporting families, advocating for patients and training healthcare professionals in similar situations to consider the implications of the published judgment for policy and practice with patients in prolonged disorders of consciousness and their families. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  9. The Effect of Aerobic Exercise on Quantity and Quality of Sleep Among Elderly People Referring to Health Centers of Lar City, Southern of Iran; A Randomized Controlled Clinical Trial.

    PubMed

    Sharif, Farkhondeh; Seddigh, Maryam; Jahanbin, Iran; Keshavarzi, Sareh

    2015-01-01

    Aging is associated with reduced quality and quantity of sleep. 50% of senior citizens living in the community and 70% of those living in nursing homes suffer from sleep disorders. Moreover, insomnia increases the risk of mortality and morbidity in older adults. We aimed to investigate the effect of aerobic exercise on quantity and quality of sleep among the elderly people referring to health centers of Lar city, southern Iran. We enrolled 60 elderly people whose age range was 60-75 years and (mean ±SD) age was (64.8±5.2). Participants were randomly assigned into two groups of 30 each (case group= 30 and control group=30). The patients in the case group participated in exercise trainings consisted of three one-hour sessions per week for 12 consecutive weeks. Sleep quantity and quantity in the participants was evaluated before and after intervention using Pittsburgh Sleep Quality Index (PSQI). Independent t-test showed that sleep quality score was improved by 44.46% in the case group (p<0.0001). Furthermore, sleep duration was improved by 98/16% (p=0.038) and sleep latency was improved by 76/6% in the case group; while, the difference between the two groups regarding the changes in the sleep latency was not statistically significant (p=0.089). Aerobic exercise program could improve the sleep quality and quantity in the elderly. It could also be used as a cost effective and long lasting method of therapy with no side effect which could be used for the treatment of insomnia in older people.

  10. When ‘Sanctity of Life’ and ‘Self-Determination’ clash: Briggs versus Briggs [2016] EWCOP 53 – implications for policy and practice

    PubMed Central

    Cowley, Jakki

    2017-01-01

    In a landmark judgment in the English Court of Protection, the judge (Charles J) found it to be in the best interests of a minimally conscious patient for clinically assisted nutrition and hydration (CANH) to be withdrawn, with the inevitable consequence that the patient would die. In making this judgment, it was accepted that the patient’s level of consciousness — if CANH were continued and rehabilitation provided — might improve, and that he might become capable of expressing emotions and making simple choices. The decision to withdraw treatment relied on a best interests decision, which gave great weight to the patient’s past wishes, feelings, values and beliefs, and brought a ‘holistic’ approach to understanding what this particular patient would have wanted. We draw on our own experience of supporting families, advocating for patients and training healthcare professionals in similar situations to consider the implications of the published judgment for policy and practice with patients in prolonged disorders of consciousness and their families. PMID:28642353

  11. A Longitudinal Study of Myers-Briggs Personality Types in Air Traffic Controllers

    DTIC Science & Technology

    2004-12-01

    Introversion .005 -.016 -.044 Sensing /Intuitive (N) .000 -.036* -.011 Thinking/ Feeling -.023 -.010 -.068** Judging/ Perceptive .035* .040...became supervisors/managers. A higher percentage of entrants fell within the Sensing -Thinking-Judging combinations (whether extroverted or...Extroversion/Introversion); ways of perceiving ( Sensing / Intuitive); how judgments are formed (Thinking/ Feeling ); and a fourth dimension, decision

  12. A Managerial View of Myers-Briggs Personality Types in the Clinical Laboratory.

    DTIC Science & Technology

    1982-12-01

    Extroverts constituted 38 per cent of the sample, introverts 62 per cent, sensing 73 per cent, intuitive 27 per cent, thinking 43 per cent, feeling ...his perceptions . A person who prefers thinking (T) analyzes impersonally with logic and objectivity. Feeling (F), on the other hand, implies analysis...Continuous Accumulated laboratory tenure excluding student experience El Dichotomous Extrovert /Introvert index Contin’uous SN Dichotomous Sensing /Intuitive

  13. Myers-Briggs Personality Type and Adolescent Coping in the College Search

    ERIC Educational Resources Information Center

    Golden, Thomas Courtenay

    2009-01-01

    The college choice requires the adolescent to gather and synthesize vast amounts of information, reconcile sometimes competing personal and familial goals, and manage a range of emotions. This decision process represents a major developmental crisis with which the adolescent must cope. Scholars have noted that psychological strain and heightened…

  14. Identifying Student Potential for ICT Entrepreneurship Using Myers-Briggs Personality Type Indicators

    ERIC Educational Resources Information Center

    Johnston, Kevin A.; Andersen, Barry K.; Davidge-Pitts, Jennifer; Ostensen-Saunders, Mark

    2009-01-01

    Literature relating to personality and entrepreneurship has focused primarily on personality characteristics of traditional entrepreneurs. The focus of this study was on personality characteristics and temperaments of potential Information and Communication Technology (ICT) entrepreneurs. The main objective of the study was to evaluate the…

  15. Working Effectively with Different Personality Types: A Look at the Myers-Briggs Type Indicator

    ERIC Educational Resources Information Center

    Khanagov, Diana

    2007-01-01

    In 1921, Carl Jung wrote about four different types of personality, identified 24 centuries ago by Hippocrates. He theorized that these differences were not abnormalities in personality. Instead, he maintained that human behavior is predictable and classifiable that everyone has and acts upon personal preferences, established in early childhood.…

  16. Working Effectively with Different Personality Types: A Look at the Myers-Briggs Type Indicator

    ERIC Educational Resources Information Center

    Khanagov, Diana

    2007-01-01

    In 1921, Carl Jung wrote about four different types of personality, identified 24 centuries ago by Hippocrates. He theorized that these differences were not abnormalities in personality. Instead, he maintained that human behavior is predictable and classifiable that everyone has and acts upon personal preferences, established in early childhood.…

  17. Myers-Briggs Personality Type and Adolescent Coping in the College Search

    ERIC Educational Resources Information Center

    Golden, Thomas Courtenay

    2009-01-01

    The college choice requires the adolescent to gather and synthesize vast amounts of information, reconcile sometimes competing personal and familial goals, and manage a range of emotions. This decision process represents a major developmental crisis with which the adolescent must cope. Scholars have noted that psychological strain and heightened…

  18. Synthesis, crystal and electronic structures, and physical properties of the novel compounds LaR4Mo36O52 (R = Dy, Er, Yb, and Y) containing infinite chains of trans-edge-shared Mo6 octahedra and Mo2 pairs and rectangular Mo4 clusters with triple Mo-Mo bonds.

    PubMed

    Barrier, N; Fontaine, B; Pierrefixe, S; Gautier, R; Gougeon, P

    2009-04-20

    The novel quaternary reduced molybdenum oxides LaR(4)Mo(36)O(52) (R = Dy, Er, Yb, and Y) have been synthesized with solid-state reactions at 1400 degrees C for 48 h in sealed molybdenum crucibles. The crystal structure was determined on a single crystal of LaEr(4)Mo(36)O(52) by X-ray diffraction. LaEr(4)Mo(36)O(52) crystallizes in the tetragonal space group I4 with two formula units per cell and the following lattice parameters: a = 19.8348(2) and c = 5.6594(1) A. The Mo network is dominated by infinite chains of trans-edge-shared Mo(6) octahedra, which coexist with Mo(2) pairs and rectangular Mo(4) clusters. The Mo-Mo distances within the infinite chains range from 2.5967(7) to 2.8529(8) A and from 2.239(3) to 2.667(2) A in the Mo(2) pairs and rectangular Mo(4) clusters, respectively. The Mo-O distances are comprised between 1.993(7) and 2.149(7) A, as usually observed in these types of compound. The La(3+) and Er(3+) ions are in a square-prismatic [LaO(8)] and a tricapped trigonal-prismatic [ErO(9)] environment of oxygen atoms, respectively. The La-O distances range from 2.555(6) to 2.719(6) A and the Er-O ones from 2.260(6) to 2.469(5) A. Theoretical calculations allow the determination of the optimal electron count of both motifs in the title compound. Weak interactions occur between neighboring dimetallic and tetrametallic clusters and between trans-edge-sharing infinite chains and dimers and tetramers. The presence of rectangular clusters is favored on the basis of theoretical considerations. Single-crystal resistivity measurements show that LaEr(4)Mo(36)O(52) is metallic between 4.2 and 300 K, in agreement with the band structure calculations. Magnetic susceptibility measurements indicate that the oxidation state of the magnetic rare earths is +3, and there is an absence of localized moments on the Mo network.

  19. Lars Onsager Prize Lecture: Statistical Dynamics of Disordered Systems

    NASA Astrophysics Data System (ADS)

    Fisher, Daniel S.

    2013-03-01

    The properties of many systems are strongly affected by quenched disorder that arose from their past history but is frozen on the time scales of interest. Although equilibrium phases and phase transitions in disordered materials can be very different from their counterparts in pure systems, the most striking phenomena involve non-equilibrium dynamics. The state of understanding of some of these will be reviewed including approach to equilibrium in spin glasses and the onset of motion in driven systems such as vortices in superconductors or earthquakes on geological faults. The potential for developing understanding of short-term evolutionary dynamics of microbial populations by taking advantage of the randomness of their past histories and the biological complexities will be discussed briefly.

  20. Lars Onsager Prize: Topological Defects in Condensed Matter Phases

    NASA Astrophysics Data System (ADS)

    Mineev, Vladimir

    2014-03-01

    Circulation quantization in superfluid 4He and superconductors. General principles of classification of topologically stable defects in ordered media. Superfluid phases of 3He. Topology at different scales of length. Superfluids under rotation. Biaxial nematics. Nonabelian disclinations. Half-quantum vortices: 3He-A, Sr2RuO4, exciton-polariton condensates, FFLO, Super Solid.

  1. Lars Onsager Prize Lecture: A Random Walk Through Theoretical Physics

    NASA Astrophysics Data System (ADS)

    Affleck, Ian

    2012-02-01

    A historical account will be given of my efforts to apply conformal field theory techniques to experimentally relevant models of condensed matter. This began with a so far unsuccessful attempt to find the exact critical exponents for the localization transition in the integer quantum Hall effect, using techniques developed by field/string theorists. It was followed by a program to classify critical behavior of Heisenberg antiferromagnetic spin chains of arbitrary spin magnitude. It eventually led to a general theory of the low energy behavior of quantum impurity models including exact solutions for non-Fermi liquid critical points.

  2. Lars Onsager Prize Talk: Flow Equations for Hamiltonians

    NASA Astrophysics Data System (ADS)

    Wegner, Franz

    2015-03-01

    The equation dH (l) = GH (l) can describe the renormalization group equation for the Hamiltonian/Lagrangian H (l) and the generator G of the group. But it can also describe a Hamiltonian flow for bosons/fermions, which eliminates the off-diagonal matrix elements or (quasi)-particle violating terms by means of unitary transformations dH (l) / dl = [ η (l) , H (l) ] . Typically off-diagonal matrix elements are eliminated for ΔE >l - 1 / 2 . The flow equation has been applied to numerous systems (F. Wegner, J. Phys. A: Math. Gen. 39 (2006) 8221, arXiv: cond-mat/0511660; S. Kehrein, The Flow Equation Approach to Many-Particle Systems, Springer 2006), among them to the two-dimensional Hubbard-model, spin-boson models, the Anderson impurity model, QED and QCD. A simple and surprising result (as compared to that by Frohlich) is obtained for the elimination of the electron-phonon interaction yielding an attractive interaction for all energies. (P. Lenz and F. Wegner, Nucl. Phys. B482 (1996) 693; arXiv: cond-mat/9604087).

  3. Lars Onsager Prize: Phase transitions in massive data acquisition

    NASA Astrophysics Data System (ADS)

    Mezard, Marc

    The rapid increase in the amount of data that is presently being generated, acquired and processed opens new perspectives in many branches of science. In order to take full advantage of this « data revolution », and to turn it into a major tool for scientific discoveries, new concepts and methods need to be developed, thus allowing us to focus on the extraction of significant information. Referring to the case of compressed sensing, the talk will show how ideas and methods in statistical physics -from spin glass theory to cristal nucleation - can help design faster, less destructive, and more efficient signal acquisition protocols, with possible applications into numerous fields -from magnetic resonance imaging to astronomy, tomography, or gene interaction network reconstruction.

  4. Telemetered electromyography of forelimb muscle chains in gibbons (Hylobates lar).

    PubMed

    Jungers, W L; Stern, J T

    1980-05-09

    Electromyographic studies of brachiation in the gibbon controvert deductions, based on dissection, about the purported functions of muscle chains in the hylobatid forelimb. Neither force conduction distally along the components of the chains nor simultaneity of muscular contraction occurs in brachiation. Rather, the unique structure of the forelimb is probably the result of evolved changes in the short head of biceps brachii to enhance its role as a forearm flexor.

  5. Evaluation of the Draeger LAR V Pure Oxygen Scuba

    DTIC Science & Technology

    1975-10-08

    SUPPLEMENTARY NOTES 19. KEY WORDS (Continue on reverse aide If necessar’y and identify by block number) r- SCUBA -PURE OXYGEN CLOSED CIRCUIT OXYGEN A03UTRACT...apparatus des~igned and manufactured in the Federal Republic of Germany. The scuba is completely closed circuit and incorporates a demand type oxygen supply...incorporates many inherent design features which makes it easier to pre/post dive and to maintain than the Emerein closed circuit scuba Test were conducted by

  6. Exploring the Relationship between Myers-Briggs Type and Instructional Perspectives among College Faculty across Academic Disciplines

    ERIC Educational Resources Information Center

    Moehl, Pamela J.

    2011-01-01

    Education has the opportunity to play an integral role in sustaining the health of our economy in an increasingly competitive, global market. A review of the issues and trends impacting higher education reveals growing pressure placed on faculty to advance instructional outcomes among more diverse populations. Imbedded is the challenge to create…

  7. Agnotology, Scientific Consensus, and the Teaching and Learning of Climate Change: A Response to Legates, Soon and Briggs

    NASA Astrophysics Data System (ADS)

    Bedford, Daniel; Cook, John

    2013-08-01

    Agnotology is a term that has been used to describe the study of ignorance and its cultural production (Proctor in Agnotology: the making and unmaking of ignorance. Stanford University Press, Stanford, 2008). For issues that are contentious in the societal realm, though largely not in the scientific realm, such as human evolution or the broad basics of human-induced climate change, it has been suggested that explicit study of relevant misinformation might be a useful teaching approach (Bedford in J Geogr 109(4):159-165, 2010). Recently, Legates et al. (Sci Educ. doi:10.1007/s11191-013-9588-3, 2013) published an aggressive critique of Bedford's (J Geogr 109(4):159-165, 2010) proposals. However, the critique is based on a comprehensive misinterpretation of Bedford's (J Geogr 109(4):159-165, 2010) paper. Consequently, Legates et al. (Sci Educ. doi:10.1007/s11191-013-9588-3, 2013) address arguments not actually made by Bedford (J Geogr 109(4):159-165, 2010). This article is a response to Legates et al. (Sci Educ. doi:10.1007/s11191-013-9588-3, 2013), and demonstrates their errors of interpretation of Bedford (J Geogr 109(4):159-165, 2010) in several key areas: the scientific consensus on climate change; misinformation and the public perception of the scientific consensus on climate change; and agnotology as a teaching tool. We conclude by arguing that, although no single peer-reviewed publication on climate change, or any other scientific issue, should be accepted without due scrutiny, the existence of a scientific consensus—especially one as overwhelming as exists for human-induced climate change—raises the level of confidence that the overall findings of that consensus are correct.

  8. Psychological Type Analysis Using Myers-Briggs Type Indicator of Air Force Personnel Undergoing Treatment for Alcoholism.

    DTIC Science & Technology

    1986-09-01

    a "sixth sense" or " extrasensory perception " because it originates within the individual. It differs from sensation because the origin of an intuition...representations of the external world, and invests itself in perceptions , thoughts, and feelings about objects, people and animals, and other environmental...times, "the introvert interposes a subjective view between the perception of the object and his own action, which pre- vents the action from assuming a

  9. Agnotology, Scientific Consensus, and the Teaching and Learning of Climate Change: A Response to Legates, Soon and Briggs

    ERIC Educational Resources Information Center

    Bedford, Daniel; Cook, John

    2013-01-01

    Agnotology is a term that has been used to describe the study of ignorance and its cultural production (Proctor in "Agnotology: the making and unmaking of ignorance." Stanford University Press, Stanford, 2008). For issues that are contentious in the societal realm, though largely not in the scientific realm, such as human evolution or…

  10. Exploring the Relationship between Myers-Briggs Type and Instructional Perspectives among College Faculty across Academic Disciplines

    ERIC Educational Resources Information Center

    Moehl, Pamela J.

    2011-01-01

    Education has the opportunity to play an integral role in sustaining the health of our economy in an increasingly competitive, global market. A review of the issues and trends impacting higher education reveals growing pressure placed on faculty to advance instructional outcomes among more diverse populations. Imbedded is the challenge to create…

  11. Agnotology, Scientific Consensus, and the Teaching and Learning of Climate Change: A Response to Legates, Soon and Briggs

    ERIC Educational Resources Information Center

    Bedford, Daniel; Cook, John

    2013-01-01

    Agnotology is a term that has been used to describe the study of ignorance and its cultural production (Proctor in "Agnotology: the making and unmaking of ignorance." Stanford University Press, Stanford, 2008). For issues that are contentious in the societal realm, though largely not in the scientific realm, such as human evolution or…

  12. Joanna Briggs Collaboration Aged Care Fellowship Project: implementing a smoking cessation program in a young, frail aged residential care facility.

    PubMed

    Nicholson, Elayne

    2008-03-01

    Background  The subject site (Ian George Court) caters for clients from a socially disadvantaged background. All clients have been homeless or at risk of homelessness and have a history of alcohol and substance abuse often linked to mental health issues. This project was developed to examine if the site provided best practice in the promotion of smoking cessation. Objectives  The first objective of this project was to improve client knowledge to make informed choice about smoking cessation, ensuring that client advice was given in line with best available evidence and assist the client in accessing community programs. The second objective was to fully review the current assessment tool used in relation to gathering baseline data about smoking habits and act on the information provided. Search strategy  The search strategy sought to find published studies and papers. An initial limited search of MEDLINE and CINAHL was undertaken followed by an analysis of the text words contained in the title and abstract. A second extensive search was then undertaken using all identified keywords. Conclusion  A smoking assessment tool was developed and is now in use across all Anglicare sites in South Australia. This provides staff with consistent baseline information and offers evidence-based health care in a package format to aid clients in smoking cessation.

  13. Quanta, a Learning Community at Daytona Beach Community College and the Use of the Myers-Briggs Type Inventory.

    ERIC Educational Resources Information Center

    Bushnell, Jay R.

    In fall 1984, a program was implemented at Daytona Beach Community College (Florida) with the dual purpose of integrating subject material between courses and establishing a close community of learners to cooperate in the mastery of subject matter. In the fall semester, participating students enroll in a block of three courses; English I,…

  14. Lars Onsager Prize Talk: Quantum fluids: from liquid helium to cold atoms

    NASA Astrophysics Data System (ADS)

    Pethick, Christopher

    2008-03-01

    The study of quantum liquids has led to ideas and concepts of broad applicability. I shall illustrate this by examples from the physics of liquid helium-3, heavy-fermion compounds, quark-gluon plasmas and cold atomic gases.

  15. Minilaparoscopy-assisted transrectal low anterior resection (LAR): a preliminary study.

    PubMed

    Lacy, Antonio M; Adelsdorfer, Cedric; Delgado, Salvadora; Sylla, Patricia; Rattner, David W

    2013-01-01

    Natural orifice translumenal endoscopic surgery (NOTES) represents the evolution of surgery towards less invasive procedures. The feasibility of NOTES transrectal approach has increased its clinical applicability. This report describes a first series of minilaparoscopy-assisted transrectal low anterior resection with double purse-string end-to-end circular stapler anastomoses. Between March and April 2012 three selected patients underwent transrectal minilaparoscopy-assisted natural orifice surgery total mesorectal excision for rectal cancer. All the oncologic principles of open/laparoscopic low anterior resection for rectal cancer were strictly fulfilled. Two patients underwent neoadjuvant treatment. Laparoscopic visualization and assistance was provided through one 10-mm umbilical port and two ports, one of which was used as stoma site (5 mm) and the other as a drain site (2 mm needle port). The specimen was transected transanally followed by the confection of double purse-string lateral/end-to-end anastomoses. There were no intraoperative complications. Mean operative time was 143 min. Oral intake was initiated on the second postoperative day. Patients were discharged home by day 5. The pathology unit confirmed that distal and circumferential margins were free of tumor invasion, and quality of mesorectum resection was reported satisfactory. One patient had to be readmitted because of severe dehydration due to increased ileostomy output. The patient was discharged at the third day after the readmission without renal failure. In this preliminary report, transrectal minilaparoscopy-assisted low anterior resection was feasible and safe. Lateral/end-to-end anastomoses can be considered an interesting alternative to the double-stapling technique. However, it is necessary to further study and develop these procedures, along with careful patient selection, before transrectal low anterior resection may be considered for routine clinical use.

  16. Lars Onsager Prize: Optimization and learning algorithms from the theory of disordered systems

    NASA Astrophysics Data System (ADS)

    Zecchina, Riccardo

    The extraction of information from large amounts of data is one of the prominent cross disciplinary challenges in contemporary science. Solving inverse and learning problems over large scale data sets requires the design of efficient optimization algorithms over very large scale networks of constraints. In such a setting, critical phenomena of the type studied in statistical physics of disordered systems often play a crucial role. This observation has lead in the last decade to a cross fertilization between statistical physics, information theory and computer science, with applications in a variety of fields. In particular a deeper geometrical understanding of the ground state structure of random computational problems and novel classes of probabilistic algorithms have emerged. In this talk I will give a brief overview of these conceptual advances and I will discuss the role that subdominant states play in the design of algorithms for large scale optimization problems. I will conclude by showing how these ideas can lead to novel applications in computational neuroscience.

  17. Protein tyrosine phosphatases PTPδ, PTPσ, and LAR: presynaptic hubs for synapse organization

    PubMed Central

    Takahashi, Hideto; Craig, Ann Marie

    2013-01-01

    Synapse development requires differentiation of presynaptic neurotransmitter release sites and postsynaptic receptive apparatus coordinated by synapse organizing proteins. In addition to the well-characterized neurexins, recent studies identified presynaptic type IIa receptor-type protein tyrosine phosphatases (RPTPs) as mediators of presynaptic differentiation and triggers of postsynaptic differentiation, thus extending the roles of RPTPs from axon outgrowth and guidance. Similarly to neurexins, RPTPs exist in multiple isoforms generated by alternative splicing that interact in a splice-selective code with diverse postsynaptic partners. The parallel RPTP and neurexin hub design facilitates synapse self-assembly through cooperation, pairs presynaptic similarity with postsynaptic diversity, and balances excitation with inhibition. Upon mutation of individual genes in neuropsychiatric disorders, imbalance of this synaptic organizing network may contribute to impaired cognitive function. PMID:23835198

  18. A readout driver for the ATLAS LAr-calorimeter at a High Luminosity LHC

    NASA Astrophysics Data System (ADS)

    Kielburg-Jeka, A.; Stärz, S.

    2011-01-01

    A new readout driver (ROD) is being developed as a central part of the signal processing of the ATLAS liquid-argon calorimeters for operation at the High Luminosity LHC (HL-LHC). In the architecture of the upgraded readout system, the ROD modules will have several challenging tasks: receiving of up to 1.4 Tb/s of data per board from the detector front-end on multiple high-speed serial links, low-latency data processing, data buffering, and data transmission to the ATLAS trigger and DAQ systems. In order to evaluate the different components, prototype boards in ATCA format equipped with modern Xilinx and Altera FPGAs have been built. We will report on the measured performance of the SERDES devices, the parallel signal processing using DSP slices, the implementation of trigger interfaces, using e.g. multi-Gb Ethernet, as well as the development of the ATCA infrastructure on the very first ROD prototype modules.

  19. Comparison of octreotide LAR and lanreotide autogel as post-operative medical treatment in acromegaly.

    PubMed

    Tutuncu, Yasemin; Berker, Dilek; Isik, Serhat; Ozuguz, Ufuk; Akbaba, Gulhan; Kucukler, Ferit Kerim; Aydin, Yusuf; Guler, Serdar

    2012-09-01

    Long-acting somatostatin analogs are frequently used as adjuvant treatment of acromegaly patients after noncurative surgery. This sudy aims to compare the efficacy of octreotide long-acting release (OCT) and lanreotide Autogel (LAN) in acromegaly patients. Sixty-eight patients not cured by transsphenoidal endoscopic or microscopic pituitary surgery between 2003 and 2009 were retrospectively analyzed (25 men; 43 women; mean age 41.1 ± 10.9 years [range 18-65 years]). The patients were assigned randomly to OCT (n = 36) and LAN (n = 32) groups. Evaluations included insulin-like growth factor I (IGF-I) and growth hormone (GH) after oral glucose tolerance test (OGTT) 3, 6, 12 and 18 months after starting medical treatment; pituitary magnetic resonance imaging was performed before treatment and after 3 and 12 months. Patients achieving IGF-I levels within the age and gender normal range and GH level <1 μg/l following OGTT were considered a 'biochemical cure'. Mean IGF-I and GH values and tumor volumes (cm(3)) in the LAN and OCT groups were similar in the post-operative period before initiation of medical treatment. A statistically significant decrease in GH and IGF-I levels was obtained for both treatment groups at each follow-up visit compared to the previous value. Tumor shrinkage after 12 months of treatment was statistically significant in both groups but the percentage tumor shrinkage (28.5% vs. 34.9%, P = 0.166) and rate of patients achieving biochemical cure (63.9 and 78.1%, P = 0.454) were similar between OCT and LAN groups, respectively. OCT and LAN treatment options have similar efficacy for ensuring biochemical cure and tumor shrinkage in acromegaly patients who had noncurative surgery.

  20. D0 Collider Detector LINDE, East Chicago (LAr Contractor) Trip Report

    SciTech Connect

    Dixon, K.; Krempetz, K.; Mulholland, G.T.; Urbin, J.; /Fermilab

    1991-02-08

    East Chicago is capable of processing air at a 6-7E6 SCFH rate. They can produce as much as 1.2E6 SCFH 02 and 4.5 SCFH N2 (not coincidently) with a peak product efficiency of 85-86% (product to total Intake). The general area demand has been as high as 10E6, as low as 4.5E6, and is currently 8E6 SCFH totaI product. The plant is really four plants in one. At anyone time one or more plants can be down for maintenance and the others online and delivering to the pipe line that distributes their product to nearby steel plants, and to the liquid reservoirs (perlite insulated tanks) of 160, 160 and 200 E6 SCF. At the time of our visit two plants were down and two were on line. The following describes the characteristics of one of the four plants. The cycle requires a base compressor (Brown Boveri, 22,600 hp) that pumps to 90-100 psig, and a booster compressor (Clark, 14,000 hp) that pumps to 300 psig. Filter houses (ca. 20-ft x 20-ft) feed the suctions and the discharge is scrubbed by dual, molecular sieve, beds 0 300 psi (6-8 hour cycle time). The beds are provided with dust blow down and down stream filter provisions. The scrubbers remove CO2, the heavy HC, and water. The effectiveness of the scrubbers is measured by the record 6 years one of the plants ran w/o the need for thawing. The thaw operation takes about 4 days. It was interesting to learn that a plant can be brought on line in two and one half hours from a warm start. Major swings from N2 rich to O2 rich production take about an hour. Argon is a small constituent in air (0.61) and thus not a major product. It comes off the main column at 761 Ar balance air components and is further purified in another column to 2% N2, 2% O2. The stream is then warmed, H2 added, and run though a palladium deoxo to combine the O2 to water. The water is removed in a dryer and the product reliquified to seperate the nitrogen. The final product is either drawn off and pumped to storage, or, in the case of case of the high purity product, pressure transfered directly from the final column to a properly cooled and purged truck backed right up to the column. The high purity product can be as low as 0.3 ppm 02 by proper application of these procedures. Liquid Argon is the only product for which standing, loaded, trailers are provided vent recovery lines. The recovered gas is fed back to the crude Ar stream. The local O2 monitoring equipment is a Teledyne 306WA with ranges of 1, 10, 100 and 1000 PPM full scale. The wet cell unit is available from ENPRO for an estimated $3,500. The N2 in Ar is measured by a special in-house Linde instrument.

  1. Acromegaly: correlation between expression of somatostatin receptor subtypes and response to octreotide-lar treatment.

    PubMed

    Casarini, Ana Paula M; Jallad, Raquel S; Pinto, Emília M; Soares, Iberê C; Nonogaki, Suely; Giannella-Neto, Daniel; Musolino, Nina R; Alves, Venâncio A F; Bronstein, Marcello D

    2009-01-01

    About one-third of acromegalics are resistant to the clinically available somatostatin analogs (SA). The resistance is related to density reduction or different expression of somatostatin receptor subtypes (SSTR). This study analyzes SSTR's expression in somatotrophinomas, comparing to SA response, hormonal levels, and tumor volume. We analyzed 39 somatotrophinomas; 49% were treated with SA. The most expressed SSTR was SSTR5, SSTR3, SSTR2, SSTR1, and SSTR4, respectively. SSTR1 and SSTR2 had higher expression in patients that had normalized GH and IGF-I. SSTR3 was more expressed in patients with tumor reduction. There was a positive correlation between the percentage of tumor reduction and SSTR1, SSTR2 and SSTR3 expression. Also, a positive correlation between SSTR2 mRNA expression and the immunohistochemical reactivity of SSTR2 was found. Our study confirmed the association between the SA response to GH and IGF-I and the SSTR2. Additionally, this finding was also demonstrated in relation to SSTR1.

  2. Exploratory investigation of the need for and feasibility of a Lower Atmosphere Research Satellite (LARS) program

    NASA Technical Reports Server (NTRS)

    1980-01-01

    The need for and feasibility of a research satellite program for the intensive study of the lower atmosphere (the troposphere and lower stratosphere) is discussed. The priorities for scientific investigation of the lower atmosphere during the next decade are examined. The findings of the study are concerned with identification of those broad research issues of highest priority and, in particular, with those that are most appropriate for investigation from space platforms.

  3. Protein tyrosine phosphatases PTPδ, PTPσ, and LAR: presynaptic hubs for synapse organization.

    PubMed

    Takahashi, Hideto; Craig, Ann Marie

    2013-09-01

    Synapse development requires differentiation of presynaptic neurotransmitter release sites and postsynaptic receptive apparatus coordinated by synapse organizing proteins. In addition to the well-characterized neurexins, recent studies identified presynaptic type IIa receptor-type protein tyrosine phosphatases (RPTPs) as mediators of presynaptic differentiation and triggers of postsynaptic differentiation, thus extending the roles of RPTPs from axon outgrowth and guidance. Similarly to neurexins, RPTPs exist in multiple isoforms generated by alternative splicing that interact in a splice-selective code with diverse postsynaptic partners. The parallel RPTP and neurexin hub design facilitates synapse self-assembly through cooperation, pairs presynaptic similarity with postsynaptic diversity, and balances excitation with inhibition. Upon mutation of individual genes in neuropsychiatric disorders, imbalance of this synaptic organizing network may contribute to impaired cognitive function.

  4. Novel technique for a symptomatic subscapularis herniation through a scapu-lar defect

    PubMed Central

    Grau, Luis; Chen, Kevin; Alhandi, Ali A; Goldberg, Benjamin

    2017-01-01

    Fractures of the scapula are rare and have been reported to account for only 1% of all fractures and 3%-5% of upper extremity fractures. Several studies have reported successful outcomes with non-operative treatment of scapula fractures. Although non-operative treatments are successful in a very high percentage of patients, very few cases of non-union of scapular body fractures have been reported. In our review of the literature, we found two case reports of scapular body fractures developed into non-unions. In both of these cases, open reduction and internal fixation with reconstruction plates and bone graft was successful at eliminating pain and restoring function. This is a case report of a patient with a symptomatic, extra-articular scapular body defect from a non-union that was treated successfully with an acellular dermal extracellular matrix and bone graft using a novel technique PMID:28251072

  5. A readout driver for the ATLAS LAr-calorimeter at a High Luminosity LHC

    NASA Astrophysics Data System (ADS)

    Kielburg-Jeka, A.; Stärz, S.

    2011-01-01

    A new readout driver (ROD) is being developed as a central part of the signal processing of the ATLAS liquid-argon calorimeters for operation at the High Luminosity LHC (HL-LHC). In the architecture of the upgraded readout system, the ROD modules will have several challenging tasks: receiving of up to 1.4 Tb/s of data per board from the detector front-end on multiple high-speed serial links, low-latency data processing, data buffering, and data transmission to the ATLAS trigger and DAQ systems. In order to evaluate the different components, prototype boards in ATCA format equipped with modern Xilinx and Altera FPGAs have been built. We will report on the measured performance of the SERDES devices, the parallel signal processing using DSP slices, the implementation of trigger interfaces, using e.g. multi-Gb Ethernet, as well as the development of the ATCA infrastructure on the very first ROD prototype modules.

  6. The Utility of the Myers-Briggs Type Indicator and the Strong Interest Inventory in Predicting Service Community Selection at the United States Naval Academy

    DTIC Science & Technology

    2002-06-01

    35 1. Analysis of Both Genders Using MBTI results as a Variable ...............38 2. Analysis...41 4. Analysis of Both Genders Using Temperament and E/I Results as Variables...49 1. Combined Gender Analysis Using MBTI Results As Predictors

  7. The Impact of Online Teaching and Learning about Emotional Intelligence, Myers Briggs Personality Dimensions and Mindfulness on Personal and Social Awareness

    ERIC Educational Resources Information Center

    Cotler, Jami L.

    2016-01-01

    As computer-meditated communication continues to evolve and become more sophisticated and accessible, the applications for this technology continue to grow. One area that has garnered a considerable amount of attention is online teaching and learning. Research has shown increasing evidence that learning outcomes of face-to-face, in comparison to…

  8. Personality Type Analysis of Air Force Institute of Technology School of Systems and Logistics Graduate Degree 85S Class Using Myers-Briggs Type Indicator.

    DTIC Science & Technology

    1985-09-01

    presentation of the resulting sixteen types is: 13 A ISTJ ISFJ INFJ INTJ ISTP ISFP INFP INTP ESTP ESFP ENFP ENTP ESTJ ESFJ ENFJ ENTJ In-depth...0.14), discounting the 0 value for the non-represented INFJ category, was for the INFP type. For six of the selection ratios (ISFJ, INTJ, ISFP, ESFP...ratios significant at the .001 level were ISTJ, INFP , ESTP, ENFP and ESTJ. 49 +.. i.++ +i- . i .- -? -’i .+. - -+’ i .+.+.-’. • .i

  9. A descriptive study of Myers-Briggs personality types of professional music educators and music therapists with comparisons to undergraduate majors.

    PubMed

    Steele, Anita Louise; Young, Sylvester

    2011-01-01

    The purpose of the current study was to determine personality types and demographic characteristics of professional music educators and music therapists. The researchers also sought to determine if personality types of professionals were consistent with undergraduate majors in those fields and personal characteristics as suggested by The Music Education National Conference (MENC) and the American Music Therapy Association (AMTA). The research of Steele and Young (2008) found strong similarities and some differences between undergraduate music education and music therapy students. The possibility that basic types extend across the life span may strengthen understanding of job satisfaction, stress, burn out and other factors affecting retention. Participants were a voluntary convenience sample of 253 music educators (n=110) and music therapists (n=143). The highest preference for music educators was Extrovert-Intuition-Feeling-Judgment (ENFJ) and the highest preference for music therapists was Introvert-Intuition-Feeling-Judgment (INFJ). The difference in the collective type of each group was their "outlook on life", which was either Extrovert or Introvert. However, both groups were the same in their secondary type functions of "NFJ". A comparison of findings with the Steele and Young (2008) study suggested small changes in personality type over time. Caution must be exercised in generalizing findings; however this descriptive investigation may serve as the basis for future studies, which should help foster a stable work force in these professions.

  10. The Maryland Career Course. Stage/Style Interactions: The Perry Scheme and the Myers-Briggs Type Indicator. Brief Report #3.

    ERIC Educational Resources Information Center

    Moore, William S.

    The Maryland career course is a one-credit career planning course for undecided undergraduates based on William Perry's (1970) model of intellectual and ethical development. The Perry model can be described using four major and sometimes overlapping divisions which represent a series of positions on learning, i.e., Dualism, Multiplicity,…

  11. The Impact of Online Teaching and Learning about Emotional Intelligence, Myers Briggs Personality Dimensions and Mindfulness on Personal and Social Awareness

    ERIC Educational Resources Information Center

    Cotler, Jami L.

    2016-01-01

    As computer-meditated communication continues to evolve and become more sophisticated and accessible, the applications for this technology continue to grow. One area that has garnered a considerable amount of attention is online teaching and learning. Research has shown increasing evidence that learning outcomes of face-to-face, in comparison to…

  12. Analyzing the Relationship of Strengths to Personality Preferences and Vocational Interests Utilizing Clifton StrengthsFinder, Myers-Briggs Type Indicator, and Strong Interest Inventory

    ERIC Educational Resources Information Center

    Schenck, Paulette M.

    2009-01-01

    Throughout the history of vocational psychology, career counselors have constantly searched for, devised, and implemented practices and techniques to best prepare clients for the world of work. The purpose of this study was to explore the relationship between strengths to personality preference and vocational interests utilizing the Myers-Briggs…

  13. Hispanic College Students' Learning Styles, Personality Types, and Gender Differences: A Collective Case Study of Ten Hispanic College Students Exposed to the Myers Briggs Type Indicator

    ERIC Educational Resources Information Center

    Harris, Rachelle D.

    2014-01-01

    The research body regarding learning styles has been abundant; however, research related to Separate and Connected learning styles has not been as copious. The purpose of this qualitative study was to explore the association between learning styles, personality types, and gender differences for Hispanic college students between the ages of 18-24…

  14. Analyzing the Relationship of Strengths to Personality Preferences and Vocational Interests Utilizing Clifton StrengthsFinder, Myers-Briggs Type Indicator, and Strong Interest Inventory

    ERIC Educational Resources Information Center

    Schenck, Paulette M.

    2009-01-01

    Throughout the history of vocational psychology, career counselors have constantly searched for, devised, and implemented practices and techniques to best prepare clients for the world of work. The purpose of this study was to explore the relationship between strengths to personality preference and vocational interests utilizing the Myers-Briggs…

  15. Hispanic College Students' Learning Styles, Personality Types, and Gender Differences: A Collective Case Study of Ten Hispanic College Students Exposed to the Myers Briggs Type Indicator

    ERIC Educational Resources Information Center

    Harris, Rachelle D.

    2014-01-01

    The research body regarding learning styles has been abundant; however, research related to Separate and Connected learning styles has not been as copious. The purpose of this qualitative study was to explore the association between learning styles, personality types, and gender differences for Hispanic college students between the ages of 18-24…

  16. Use of LARS system for the quantitative determination of smoke plume lateral diffusion coefficients from ERTS images of Virginia

    NASA Technical Reports Server (NTRS)

    Blais, R. N.; Copeland, G. E.; Lerner, T. H.

    1975-01-01

    A technique for measuring smoke plume of large industrial sources observed by satellite using LARSYS is proposed. A Gaussian plume model is described, integrated in the vertical, and inverted to yield a form for the lateral diffusion coefficient, Ky. Given u, wind speed; y sub l, the horizontal distance of a line of constant brightness from the plume symmetry axis a distance x sub l, downstream from reference point at x=x sub 2, y=0, then K sub y = u ((y sub 1) to the 2nd power)/2 x sub 1 1n (x sub 2/x sub 1). The technique is applied to a plume from a power plant at Chester, Virginia, imaged August 31, 1973 by LANDSAT I. The plume bends slightly to the left 4.3 km from the source and estimates yield Ky of 28 sq m/sec near the source, and 19 sq m/sec beyond the bend. Maximum ground concentrations are estimated between 32 and 64 ug/cu m. Existing meteorological data would not explain such concentrations.

  17. Combined treatment with octreotide LAR and pegvisomant in patients with pituitary gigantism: clinical evaluation and genetic screening.

    PubMed

    Mangupli, Ruth; Rostomyan, Liliya; Castermans, Emilie; Caberg, Jean-Hubert; Camperos, Paul; Krivoy, Jaime; Cuauro, Elvia; Bours, Vincent; Daly, Adrian F; Beckers, Albert

    2016-10-01

    Pituitary gigantism is a rare condition caused by growth hormone secreting hypersecretion, usually by a pituitary tumor. Acromegaly and gigantism cases that have a genetic cause are challenging to treat, due to large tumor size and poor responses to some medical therapies (e.g. AIP mutation affected cases and those with X-linked acrogigantism syndrome). We performed a retrospective study to identify gigantism cases among 160 somatotropinoma patients treated between 1985 and 2015 at the University Hospital of Caracas, Venezuela. We studied clinical details at diagnosis, hormonal responses to therapy and undertook targeted genetic testing. Among the 160 cases, eight patients (six males; 75 %) were diagnosed with pituitary gigantism and underwent genetic analysis that included array comparative genome hybridization for Xq26.3 duplications. All patients had GH secreting pituitary macroadenomas that were difficult to control with conventional treatment options, such as surgery or primary somatostatin receptor ligand (SRL) therapy. Combined therapy (long-acting SRL and pegvisomant) as primary treatment or after pituitary surgery and radiotherapy permitted the normalization of IGF-1 levels and clinical improvement. Novel AIP mutations were the found in three patients. None of the patients had Xq26.3 microduplications. Treatment of pituitary gigantism is frequently challenging; delayed control increases the harmful effects of GH excess, such as, excessive stature and symptom burden, so early diagnosis and effective treatment are particularly important in these cases.

  18. Experimental lepromatous leprosy in the white-handed gibbon (Hylobatus lar): successful inoculation with leprosy bacilli of human origin.

    PubMed

    Waters, M F; Bakri, I B; Isa, H J; Rees, R J; McDougall, A C

    1978-12-01

    Leprosy bacilli of human origin were inoculated into a white-handed gibbon by the i.v. and i.p. routes, and also locally into ears, testis and around an ulnar nerve. The animal was observed closely during a period of nearly 15 years and did not exhibit any clinical evidence of cutaneous or neurological disease. At death, a wide range of tissues was taken for bacterial counts and histological examination, and a disseminated and progressive infection was demonstrated. Acid-fast bacilli were found in many sites; their morphological appearance distribution in nerves, and pattern of multiplication in mouse foot-pads, and also the presence of anti-mycobacterial antibody in the serum and the absence of specific lymphocyte transformation were all in keeping with an infection by Mycobacterium leprae, at an early lepromatous stage. This is probably the first fully documented report of experimental lepromatous infection in a primate. The findings are discussed in relation to the long incubation period of le promatous leprosy and the difficulties of diagnosing the disease at an early stage in man.

  19. D0 Silicon Upgrade: Summary of Warm-Up After Draining for the D-Zero LAr Calorimeters

    SciTech Connect

    Rucinski, Russ; /Fermilab

    1996-03-14

    After a very successful physics run, the D-Zero detector Liquid Argon Calorimeters were drained in preparation of the detector rollout. During the roll out process, the calorimeters were without cooling. Information regarding the temperatures, estimated heat transfer, and pressure maintenance are documented in this engineering note.

  20. A 12 bit 40 MSPS SAR ADC with a redundancy algorithm and digital calibration for the ATLAS LAr calorimeter readout

    NASA Astrophysics Data System (ADS)

    Zeloufi, M.

    2016-01-01

    We present a SAR ADC with a generalized redundant search algorithm offering the flexibility to relax the requirements on the DAC settling time. The redundancy also allows a digital background calibration, based on a code density analysis, to compensate for the capacitor mismatch effects. The total number of capacitors used in this architecture is limited to one half of the one in a classical SAR design. Only 211 unit capacitors were necessary to reach 12 bit resolution, and the switching algorithm is intrinsically monotonic. The design is fully differential featuring 12 bit 40 MS/s in a CMOS 130 nm 1P8M process.

  1. Muon momentum measurement in ICARUS-T600 LAr-TPC via multiple scattering in few-GeV range

    NASA Astrophysics Data System (ADS)

    Antonello, M.; Baibussinov, B.; Bellini, V.; Benetti, P.; Boffelli, F.; Bubak, A.; Calligarich, E.; Centro, S.; Cervi, T.; Cesana, A.; Cieslik, K.; Cocco, A. G.; Dabrowska, A.; Dermenev, A.; Falcone, A.; Farnese, C.; Fava, A.; Ferrari, A.; Gibin, D.; Gninenko, S.; Guglielmi, A.; Haranczyk, M.; Holeczek, J.; Janik, M.; Kirsanov, M.; Kisiel, J.; Kochanek, I.; Lagoda, J.; Menegolli, A.; Meng, G.; Montanari, C.; Otwinowski, S.; Picchi, P.; Pietropaolo, F.; Plonski, P.; Rappoldi, A.; Raselli, G. L.; Rossella, M.; Rubbia, C.; Sala, P.; Scaramelli, A.; Sergiampietri, F.; Spanu, M.; Stefan, D.; Sulej, R.; Szarska, M.; Terrani, M.; Torti, M.; Tortorici, F.; Varanini, F.; Ventura, S.; Vignoli, C.; Wang, H.; Yang, X.; Zalewska, A.; Zani, A.; Zaremba, K.

    2017-04-01

    The measurement of muon momentum by Multiple Coulomb Scattering is a crucial ingredient to the reconstruction of νμ CC events in the ICARUS-T600 liquid argon TPC in absence of magnetic field, as in the search for sterile neutrinos at Fermilab where ICARUS will be exposed to ~ 1 GeV Booster neutrino beam. A sample of ~ 1000 stopping muons produced by charged current interactions of CNGS νμ in the surrounding rock at the INFN Gran Sasso underground Laboratory provides an ideal benchmark in the few-GeV range since their momentum can be directly and independently obtained by the calorimetric measurement. Stopping muon momentum in the 0.5-4.5 GeV/c range has been reconstructed via Multiple Coulomb Scattering with resolution ranging from 10 to 25% depending on muon energy, track length and uniformity of the electric field in the drift volume.

  2. Tactical Symbology Catalog

    DTIC Science & Technology

    1983-05-01

    PRIMITIVE DELETION INSTRUCTIONS G IC PRIMITIVE GRAPHIC PRIMITIVES GRHIC PRIMITIVES I &ins 23 larP 45 medJ 2 Y 24 larQ 46 medK 3 activttyarrow4 25 larR 47...GRAPHIC PRIMITIVES GRAPIC PRIMITIVES GRAPIC PRIMITBES I 2asnl 23 larP 45 medJ 2 VMA 4 larQ 46 medK 3 activityarrow4 25 larR 47 medL 4 arrow 26 larS

  3. An Identification of Interpersonal Skills for Building Army Civilian Leaders

    DTIC Science & Technology

    2006-09-01

    Development Course MBTI Myers-Briggs Type Indicator MDC Manager Development Course NSPS National Security Personnel System O Officer OLE...face communication, public speaking, in writing, verbally, and through briefings. The Myers-Briggs Type Indicator ( MBTI ) personality inventory

  4. Building Efficient and Effective Strategic Intelligence Teams

    DTIC Science & Technology

    2012-03-22

    this useful understanding is the Myer’s Briggs Type Indicator (MBTI). Developed by psychologist Carl Jung, Isabel Briggs Myers and Katharine Cook...collaboration across the U.S. interagencies. 15. SUBJECT TERMS Human Resources, Myer’s Briggs Type Indicator, National Intelligence Agencies...FORMAT: Strategy Research Project DATE: 22 MARCH 2012 WORD COUNT: 5,053 PAGES: 26 KEY TERMS: Human Resources, Myer’s Briggs Type Indicator

  5. Management: Towards a Unified Field Theory

    DTIC Science & Technology

    2000-01-01

    Myers - Briggs type indicator . Palo Alto, CA: Consulting Psychologists Press. Cascio, W. (1978). Applied psychology in personnel...which com- bined “situational leadership II” with the Myers - Briggs Type Indicator (MBTI) ( Briggs - Myers and McCaulley, 1985). Of course, his most well...that people differ. The exten- sion to the Myers - Briggs is, thus, a very logical one. The latter is a model of 16 types of preferences to

  6. Practicing Strategic Leadership Without a License

    DTIC Science & Technology

    2010-05-05

    4 Isabel Briggs Myers and Peter B. Myers , Gifts Differing: Understanding Personality Type (Palo Alto, CA: Davies-Black...BIBLIOGRAPHY Ackoff, Russell L. The Art of Problem Solving. New York: John Wiley & Sons, 1978. Briggs Myers , Isabel. Type and Teamwork. Gainesville, FL...Center for Applications of Psychological Type, Inc., 1974. Briggs Myers , Isabel, and Peter B. Myers . Gifts Differing: Understanding Personality Type

  7. Lars Onsager Prize: The mean field solution for Hard Sphere Jamming and a new scenario for the low temperature landscape of glasses

    NASA Astrophysics Data System (ADS)

    Parisi, Giorgio

    In a hard spheres systems particles cannot overlap. Increasing the density we reach a point where most of the particles are blocked and the density cannot be increased any more: this is the jamming point. The jamming point separates the phase, where all the constraint can be satisfied, from an unsatifiable phase, where spheres do have to overlap. A scaling theory of the behavior around the jamming critical point has been formulated and a few critical exponents have been introduced. The exponents are apparently super-universal, as far as they do seem to be independent from the space dimensions. The mean field version of the model (i.e. the infinite dimensions limit) has been solved analytically using broken replica symmetry techniques and the computed critical exponents have been found in a remarkable agreement with three-dimensional and two-dimensional numerical results and experiments. The theory predicts in hard spheres (in glasses) a new transition (the Gardener transition) from the replica symmetric phase to the replica broken phase at high density (at low temperature), in agreement with simulations on hard sphere systems. I will briefly discuss the possible consequences of this new picture on the very low temperature behavior of glasses in the quantum regime.

  8. Lars Onsager Prize Talk: A New Challenge for Cold Atom Physics: Achieving the Strongly Correlated Regimes for Cold Atoms in Optical Lattices.

    NASA Astrophysics Data System (ADS)

    Ho, Tin-Lun

    2008-03-01

    Cold atoms in optical lattices show great promise to generate a whole host of new strongly correlated states and to emulate many theoretical models for strongly interacting electronic systems. However, to reach these strongly correlated regimes, we need to reach unprecedented low temperatures within current experimental settings. To achieve this, it is necessary to remove considerable amount of entropy from the system. Here, we point out a general principle for removing entropies of quantum gases in optical lattices which will allow one to reach some extraordinarily low temperature scales.

  9. Lars Onsager Prize Talk: 1+1d conformal field theories as natural languages for asymptotically large-scale quantum computing

    NASA Astrophysics Data System (ADS)

    Friedan, Daniel

    2010-03-01

    An abstract argument is offered that the ideal physical systems for asymptotically large-scale quantum computers are near-critical quantum circuits, critical in the bulk, whose bulk universality classes are described by 1+1d conformal field theories. One in particular -- the Monster conformal field theory -- is especially ideal, because all of its bulk couplings are irrelevant.

  10. Bacterial Contamination of Anaesthetic and Vasopressor Drugs in the Operating Theatres: Ameliyathanelerde Anestetik ve Vazopressör İlaçların Bakteriyel Kontaminasyonu.

    PubMed

    Rueangchira-Urai, Rongrong; Rujirojindakul, Panthila; Geater, Alan Frederick; McNeil, Edward

    2017-02-01

    The aim of this study was to determine the incidence of bacterial and fungal contamination in anaesthetic and vasopressor drugs before and after use in operating theatres. A cross-sectional study was conducted in the operating theatres of a university hospital. We collected 945 samples of three different drugs, namely, propofol, vecuronium and ephedrine, from 20 operating rooms and refrigerators where the unused drugs were stored. Each drug was divided into two groups, the pre-use group and the post-use group. The pre-use drugs were cultured before the patient received the drug. The post-use drugs were cultured after the patient had received the drug or after the drugs had been transferred to other syringes. The culture results were reported as either positive or negative. Out of the 945 drug samples, 26 (2.8%, 95% confidence interval=1.8%-4.0%) gave a positive culture. Of the 317 propofol samples, 20 (6.3%) were found to have bacterial contamination, 11 in the pre-use group and 9 in the post-use group. Of the 318 ephedrine samples, 6 (1.9%) were found to be positive on culture, one in the pre-use group and five in the post-use group. Vecuronium gave no positive cultures. All organisms were non-pathogenic, and no fungal contamination was found. The incidence of bacterial contamination in anaesthetic and vasopressor drugs was 2.8%. Anaesthetic teams must be aware of contamination issues in anaesthetic drugs that have been prepared for later use and, in order to reduce the risk of contamination, they must improve the methods of administering drugs to patients.

  11. Application of satellite data and LARS's data processing techniques to mapping vegetation of the Dismal Swamp. M.S. Thesis - Old Dominion Univ.

    NASA Technical Reports Server (NTRS)

    Messmore, J. A.

    1976-01-01

    The feasibility of using digital satellite imagery and automatic data processing techniques as a means of mapping swamp forest vegetation was considered, using multispectral scanner data acquired by the LANDSAT-1 satellite. The site for this investigation was the Dismal Swamp, a 210,000 acre swamp forest located south of Suffolk, Va. on the Virginia-North Carolina border. Two basic classification strategies were employed. The initial classification utilized unsupervised techniques which produced a map of the swamp indicating the distribution of thirteen forest spectral classes. These classes were later combined into three informational categories: Atlantic white cedar (Chamaecyparis thyoides), Loblolly pine (Pinus taeda), and deciduous forest. The subsequent classification employed supervised techniques which mapped Atlantic white cedar, Loblolly pine, deciduous forest, water and agriculture within the study site. A classification accuracy of 82.5% was produced by unsupervised techniques compared with 89% accuracy using supervised techniques.

  12. The Arches Cluster Out to its Tidal Radius: Dynamical Mass Segregation and the Effect of the Extinction Law on the - Lar Mass Function

    NASA Astrophysics Data System (ADS)

    Habibi, Maryam; Stolte, Andrea; Brandner, Wolfgang; Hussman, Benjamin

    2013-07-01

    The Galactic Center is the most active site of star formation in the Milky Way Galaxy, where particularly high-mass stars have formed very recently and are still forming today. However, since we are looking at the Galactic Center through the Galactic disk, knowledge of extinction is crucial to study this region. The Arches cluster is a young, massive starburst cluster near the Galactic Center. We observed the Arches cluster out to its tidal radius using Ks-band imaging obtained with NAOS/CONICA at the VLT combined with Subaro/Cisco J-band data to gain a full understanding of the cluster mass distribution. We show that the determination of the mass of the most massive star in the Arches cluster, which had been used in previous studies to establish an upper-mass limit for the star formation process in the Milky Way, strongly depends on the assumed slope of the extinction law. Assuming the two regimes of widely used infrared extinction laws, we show that the difference can reach up to 30% for individually derived stellar masses and ∆AKs˜1 magnitude in acquired Ks-band extinction, while the present mass function slope changes by ˜0.17 dex. The present-day mass function slope derived assuming the Nishiyama et al. (2009) extinction law increases from a flat slope of α-Nishi = 1.50 ± 0.35 in the core (r<0.2 pc) to α-Nishi = 2.21±0.27 in the intermediate annulus (0.2

  13. Milk composition of captive vervet monkey (Chlorocebus pygerythrus) and rhesus macaque (Macaca mulatta) with observations on gorilla (Gorilla gorilla gorilla) and white handed gibbon (Hylobates lar).

    PubMed

    Osthoff, G; Hugo, A; de Wit, M; Nguyen, T P M; Seier, J

    2009-04-01

    The nutrient content and fatty acid composition of vervet monkey milk has been determined and is compared with rhesus macaque, and two hominoid apes, the white handed gibbon and gorilla. With 15.7+/-4.1 g protein, 33.1+/-9.4 g fat, and 85.1+/-7.5 g lactose per kg milk, vervet monkey milk does not differ from that of rhesus macaque, and is within the range of other primates. Small amounts (>1 g kg(-1)) of oligosaccharides, glucose, galactose and fucose were noted. In comparison, gorilla milk has a low fat content of 13.8 g kg(-1), but contains high levels of oligosaccharides at 7.0 g kg(-1) milk. The hominoid partner, the white handed gibbon, contains no oligosaccharides and a milk fat content similar to other hominoid species. Differences between vervet monkey and rhesus macaque milks were observed in the electrophoretic pattern of the milk proteins, mainly amongst the kappa- and gamma-caseins, which also differ from that of the hominids. The fatty acid contents of these milks differ from studies where a natural diet of leafy material was available in that a low content of alpha-linolenic acid (18:3n-3) was noted. A phylogenetic effect is observed for the content of 8:0, 10:0 fatty acids between the Cercopithecidae and Hominoidea, and a further phylogenetic effect suggested between the Hylobatidae and Hominidae.

  14. Personality and the Planning Process

    DTIC Science & Technology

    2001-01-01

    staff officers. This paper is based on theories of personality type (C.G. Jung?s psychological types, Katherine Briggs and Isabel Briggs Myers work on...commanders and individual staff officers. This paper is based on theories of personality type (C.G. Jung’s psychological types, Katherine Briggs and Isabel...wrote about rudimentary psychology before it was a mature field. A most important aspect inferred from his writing is that there exists a personality

  15. Characterization of Truck-Mounted Atomization Equipment Typically Used in Vector Control

    DTIC Science & Technology

    2007-01-01

    Briggs & Stratton gasoline engine that drives a rotary positive displacement...Chemical Aerosol Generator (London Fog): The M.A.G. is an ULV aerosol generator that is powered by a 3.5-hp Briggs & Stratton gasoline engine. It...St. Louis, MO): The Model G-4 is a ULV chemical dispersal unit powered by a 5-hp Briggs & Stratton gasoline engine. The pesticide droplet spectrum

  16. Castles in the Clouds: The Irrelevance of Vertical Scales for Most Practical Concerns

    ERIC Educational Resources Information Center

    Ho, Andrew

    2016-01-01

    This is a response to a focus article by Briggs and Peck (2015) in issue 13(2). It should have been published in issue 13(3-4) alongside a rejoinder by Briggs and Peck that did appear. Due to an oversight, it was not published there and appears here. See issue 13(3-4) for a rejoinder to this response. Briggs and Peck (2015) propose what amounts to…

  17. Castles in the Clouds: The Irrelevance of Vertical Scales for Most Practical Concerns

    ERIC Educational Resources Information Center

    Ho, Andrew

    2016-01-01

    This is a response to a focus article by Briggs and Peck (2015) in issue 13(2). It should have been published in issue 13(3-4) alongside a rejoinder by Briggs and Peck that did appear. Due to an oversight, it was not published there and appears here. See issue 13(3-4) for a rejoinder to this response. Briggs and Peck (2015) propose what amounts to…

  18. Intuition: A Needed Component of Leadership for Decision-making in Today’s Technology Driven Air Force

    DTIC Science & Technology

    2009-12-15

    in the decision -making process. 29 During orientation observed data is 26 The Myers Briggs ...assessment tool is the Myers Briggs Type Indicator (MBTI). 26 The MBTI has been a reliable and valid assessment tool over the last 40 years. 27 The...1997. The Myers Briggs Foundation. Http://www.myersbriggs.org. Noddings, Nel and Paul Shore. Awakening The Inner Eye: Intuition In Education. New

  19. Battle Space Action Centers

    DTIC Science & Technology

    2011-05-14

    Systems 3RD Annual Conference, Eau Claire, Wisconsin, May 2008. 57. VREEDE, G.J. DE, BRIGGS, R.O. REINIG, B. (2008), E-Collaboration Satisfaction...Systems 3RD Annual Conference, Eau Claire, Wisconsin, May 2008. 90. Vreede, G.J. De, Briggs, R.O. Reinig, B. (2008), E-Collaboration Satisfaction

  20. Modified Betatron Accelerator Studies.

    DTIC Science & Technology

    1983-12-01

    Stability Calcula- tions," AMRC-N-207 (Mission Research Corporation, Albuquerque, 1982). 6. T. J. Fessenden , W. A. Atchison, D. L. Birx, R. J. Briggs...Hughes, AMRC-N-207 (Mission Research Corpora- tion, Albuquerque, 1982). *6. T. J. Fessenden , W. A. Atchison, D. L. Blrx, R. J. Briggs, J. C. Clark, R. E

  1. Our Hidden Prejudices, on Trial

    ERIC Educational Resources Information Center

    Glenn, David

    2008-01-01

    In October 2006, a New Hampshire police officer named Michael Briggs was shot to death in an alley. His accused killer, Michael Addison, has been charged with capital murder. It is the state's first death-penalty case in more than 30 years, and it is racially fraught: Addison is African-American, and Briggs was white. New Hampshire has a long list…

  2. Our Hidden Prejudices, on Trial

    ERIC Educational Resources Information Center

    Glenn, David

    2008-01-01

    In October 2006, a New Hampshire police officer named Michael Briggs was shot to death in an alley. His accused killer, Michael Addison, has been charged with capital murder. It is the state's first death-penalty case in more than 30 years, and it is racially fraught: Addison is African-American, and Briggs was white. New Hampshire has a long list…

  3. Alternative Ways of Measuring Counselees' Jungian Psychological-Type Preferences

    ERIC Educational Resources Information Center

    Vacha-Haase, Tammi; Thompson, Bruce

    2002-01-01

    Instruments measuring Carl Jung's (1921/1971) theory of psychological types have been widely used in various counseling contexts, including career counseling, marital and family therapy, and team building. The most popular measure of types, the Myers-Briggs Type Indicator (MBTI), was developed by Katherine C. Briggs and her daughter, Isabel Briggs…

  4. Crisis Thinking, Sensuous Reflexivity, and Solving Real Issues

    ERIC Educational Resources Information Center

    Jaspers, Jürgen

    2016-01-01

    In "Voices of Modernity," Richard Bauman and Charles Briggs write their grand overview of the birth and maturation of modernity. Bauman and Briggs understand modernity as a discursive construction that opposes traditional and modern developments, ways of being, and modes of understanding. Central in this narrative project of modernity…

  5. Alternative Ways of Measuring Counselees' Jungian Psychological-Type Preferences

    ERIC Educational Resources Information Center

    Vacha-Haase, Tammi; Thompson, Bruce

    2002-01-01

    Instruments measuring Carl Jung's (1921/1971) theory of psychological types have been widely used in various counseling contexts, including career counseling, marital and family therapy, and team building. The most popular measure of types, the Myers-Briggs Type Indicator (MBTI), was developed by Katherine C. Briggs and her daughter, Isabel Briggs…

  6. Psychometric Properties of Scores on a New Measure of Psychological Type.

    ERIC Educational Resources Information Center

    Vacha-Haase, Tammi; Thompson, Bruce

    Instruments measuring Carl Jung's (1921/1971) theory of psychological types have been widely used in various counseling contexts. The most popular measure of types has been the Myers-Briggs Type Indicator (K. Briggs and I. Myers). This measure has been criticized for dichotomous scoring, forced-choice response formats, and differential gender…

  7. Information Processing Patterns of Postsecondary American Indian/Alaska Native Students

    ERIC Educational Resources Information Center

    Aragon, Steven R.

    2004-01-01

    In the last of a three-part series, this study examined the information processing patterns of postsecondary American Indian/Alaska Native students attending community and tribal colleges in the Southwest. Using a survey design, students completed the Kolb Learning Style Inventory, the Briggs and Myers Myers-Briggs Type Indicator, and the Oltman,…

  8. A Systematic Review of the Literature to Support an Evidence-based Precepting Program

    DTIC Science & Technology

    2014-01-01

    comparing the Myers Briggs type indicator and the Keirsey Temperament Sorter. In: Boyar LS, editor. New psychological tests and testing research...Temperament Sorter II. J Career Assess 2001;9(1):49 59. [28] Quinn MT, Lewis R, Fischer K. A cross correlation of the Myers Briggs and Keirsey instruments. J

  9. Crisis Thinking, Sensuous Reflexivity, and Solving Real Issues

    ERIC Educational Resources Information Center

    Jaspers, Jürgen

    2016-01-01

    In "Voices of Modernity," Richard Bauman and Charles Briggs write their grand overview of the birth and maturation of modernity. Bauman and Briggs understand modernity as a discursive construction that opposes traditional and modern developments, ways of being, and modes of understanding. Central in this narrative project of modernity…

  10. Information Processing Patterns of Postsecondary American Indian/Alaska Native Students

    ERIC Educational Resources Information Center

    Aragon, Steven R.

    2004-01-01

    In the last of a three-part series, this study examined the information processing patterns of postsecondary American Indian/Alaska Native students attending community and tribal colleges in the Southwest. Using a survey design, students completed the Kolb Learning Style Inventory, the Briggs and Myers Myers-Briggs Type Indicator, and the Oltman,…

  11. 77 FR 46110 - Notice of Application for Proposed Withdrawal Extension and Opportunity for Public Meeting; Oregon

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-02

    .../wildlife habitat values in the scenic section of the Illinois Wild and Scenic River between the mouth of Deer Creek and the mouth of Briggs Creek. The withdrawal created by PLO No. 6986 will expire on June 30... section of the Illinois Wild and Scenic River between the mouth of Deer Creek and the mouth of Briggs...

  12. Preoperative, intraoperative and postoperative risk factors for anastomotic leakage after laparoscopic low anterior resection with double stapling technique anastomosis

    PubMed Central

    Kawada, Kenji; Sakai, Yoshiharu

    2016-01-01

    Anastomotic leakage (AL) is one of the most devastating complications after rectal cancer surgery. The double stapling technique has greatly facilitated intestinal reconstruction especially for anastomosis after low anterior resection (LAR). Risk factor analyses for AL after open LAR have been widely reported. However, a few studies have analyzed the risk factors for AL after laparoscopic LAR. Laparoscopic rectal surgery provides an excellent operative field in a narrow pelvic space, and enables total mesorectal excision surgery and preservation of the autonomic nervous system with greater precision. However, rectal transection using a laparoscopic linear stapler is relatively difficult compared with open surgery because of the width and limited performance of the linear stapler. Moreover, laparoscopic LAR exhibits a different postoperative course compared with open LAR, which suggests that the risk factors for AL after laparoscopic LAR may also differ from those after open LAR. In this review, we will discuss the risk factors for AL after laparoscopic LAR. PMID:27433085

  13. 78 FR 57664 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-19

    ...: September 19, 2013. FOR FURTHER INFORMATION CONTACT: Robin W. Edwards, Patent Counsel, Langley Research....: LAR-18065-1: Variable Acceleration Force Calibration System; NASA Case No.: LAR-18127-1: A...

  14. 74 FR 10623 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2009-03-11

    ... Damage Location Sensing System; NASA Case No. LAR-17044-1: Method of Generating X-Ray Diffraction Data... Properties and Devices Based on Such Materials; NASA Case No. LAR-17554-1: X-ray Diffraction Wafer...

  15. Petrology and Geochemistry of New Paired Martian Meteorites Larkman Nunatak 12240 and Larkman Nunatak 12095

    NASA Astrophysics Data System (ADS)

    Funk, R. C.; Peslier, A. H.; Brandon, A. D.; Humayun, M.

    2016-08-01

    Two of the latest Martian meteorites found in Antarctica, paired olivine-phyric shergottites LAR 12240 and LAR 12095, are described in order to decipher their petrological context, and place constraints on the geological history of Mars.

  16. 78 FR 29387 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ... Generator; NASA Case No.: LAR-18131-1: Puncture-Healing Thermoplastic Resin Carbon-Fiber Reinforced Composites; NASA Case No.: LAR-18089-1: Fluidic Oscillator Array for Synchronized Oscillating Jet Generation...

  17. 78 FR 19743 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-02

    ....: LAR-18202-1: Method for Ground-to-Space Laser Calibration System; NASA Case No.: LAR-18132-1: Modeling of Laser Ablation and Plume Chemistry in a Boron Nitride Nanotube Production Rig; NASA Case No.:...

  18. Current and future liquid argon neutrino experiments

    SciTech Connect

    Karagiorgi, Georgia S.

    2015-05-15

    The liquid argon time projection chamber (LArTPC) detector technology provides an opportunity for precision neutrino oscillation measurements, neutrino cross section measurements, and searches for rare processes, such as SuperNova neutrino detection. These proceedings review current and future LArTPC neutrino experiments. Particular focus is paid to the ICARUS, MicroBooNE, LAr1, 2-LArTPC at CERN-SPS, LBNE, and 100 kton at Okinoshima experiments.

  19. Further studies of electron avalanche gain in liquid argon

    SciTech Connect

    Kim, J.G.; Dardin, S.M.; Kadel, R.W.; Kadyk, J.A.; Jackson, K.H.; Peskov, V.; Wenzel, W.A.; Joo, K.S.

    2003-03-07

    Previously we showed how small admixtures of xenon (Xe) stabilize electron avalanches in liquid Argon (LAr). In the present work, we have measured the positive charge carrier mobility in LAr with small admixtures of Xe to be 6.4 x 10{sup -3} cm{sup 2}/Vsec, in approximate agreement with the mobility measured in pure LAr, and consistent with holes as charge carriers. We have measured the concentration of Xe actually dissolved in the liquid and compared the results with expectations based on the amount of Xe gas added to the LAr. We also have tested LAr doped with krypton to investigate the mechanism of avalanche stabilization.

  20. An Operational Definition of the Steady State in Enzyme Kinetics.

    ERIC Educational Resources Information Center

    Barnsley, E. A.

    1990-01-01

    The Briggs-Haldane assumption is used as the basis for the development of a kinetic model for enzyme catalysis. An alternative definition of the steady state and examples of realistic mechanisms are provided. (KR)

  1. Human Robotic Study at Houghton Crater - virtual reality study from NASA Ames (FFC) Future Fight

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Human Robotic Study at Houghton Crater - virtual reality study from NASA Ames (FFC) Future Fight Central simulator tower L-R: Dr Geoffrey Briggs; Jen Jasper (seated); Dr Jan Akins and Mr. Tony Gross, Ames

  2. Unlocking Personality Type.

    ERIC Educational Resources Information Center

    Tieger, Paul D.

    2002-01-01

    This article examines some of the intricacies of personality types and their effect on career choices. Proposes that knowing students' Myers-Briggs personality types can help school counselors guide them down the right career path. (GCP)

  3. 78 FR 77778 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ..., macular scar, esotropia, macular hole, visual acuity loss, cataract, chronic angle closure glaucoma...), Thomas A. Black (MO), Eugene R. Briggs (MI), Matthew S. Burns (OH), Ryan J. Burnworth (MO), Dennis...

  4. The Learning Styles of Agriculture Preservice Teachers as Assessed by the MBTI.

    ERIC Educational Resources Information Center

    Cano, Jamie; Garton, Bryan L.

    1994-01-01

    The Myers Briggs Type Indicator was completed by 82 preservice agricultural education teachers. All 16 types were reflected; the most common were Extrovert Sensing Thinking Judging (23%), Introvert Sensing Thinking Judging (18%), and Extrovert Sensing Feeling Judging (13%). (SK)

  5. ARC-2002-ACD02-0141-001

    NASA Image and Video Library

    2002-07-25

    Human Robotic Study at Houghton Crater - virtual reality study from NASA Ames (FFC) Future Fight Central simulator tower L-R: Dr Geoffrey Briggs; Jen Jasper (seated); Dr Jan Akins and Mr. Tony Gross, Ames

  6. Human Robotic Study at Houghton Crater - virtual reality study from NASA Ames (FFC) Future Fight

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Human Robotic Study at Houghton Crater - virtual reality study from NASA Ames (FFC) Future Fight Central simulator tower L-R: Dr Geoffrey Briggs; Jen Jasper (seated); Dr Jan Akins and Mr. Tony Gross, Ames

  7. 78 FR 58286 - Export Trade Certificate of Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-23

    ...: Magic Circle Corporation d/b/a Dixie Chopper (Coatesville, IN) and Briggs & Stratton Corporation... Ingersoll Equipment Company, Inc., Winnecone, WI Kut-Kwick Corporation, Brunswick, GA Magic Circle...

  8. Relationship of self-management to personality types and indices.

    PubMed

    Williams, R L; Verble, J S; Price, D E; Layne, B H

    1995-06-01

    This study addressed the relationship between self-management (as measured by the Lifestyle Approaches Inventory, Williams, Moore, Pettibone, & Thomas, 1992) and personality types and indexes (as measured by the Myers-Briggs Type Indicator, Myers & McCaulley, 1985) in a sample of 347 university students. Correlational analyses indicated that the self-management factor most consistently linked to the Myers-Briggs indices was Organization of Physical Space. The Myers-Briggs index most consistently correlated with the self-management factors was Judgment-Perception. Overall, male and female subjects showed similar patterns of relationships between the self-management and personality indices. When the self-management scores were compared for the various Myers-Briggs types, the analysis indicated that types having a J (planful and organized) or S (precise and practical) in the typology tended to score higher than those having a P (spontaneous and flexible) or N (imaginative and insightful).

  9. An Operational Definition of the Steady State in Enzyme Kinetics.

    ERIC Educational Resources Information Center

    Barnsley, E. A.

    1990-01-01

    The Briggs-Haldane assumption is used as the basis for the development of a kinetic model for enzyme catalysis. An alternative definition of the steady state and examples of realistic mechanisms are provided. (KR)

  10. The Learning Styles of Agriculture Preservice Teachers as Assessed by the MBTI.

    ERIC Educational Resources Information Center

    Cano, Jamie; Garton, Bryan L.

    1994-01-01

    The Myers Briggs Type Indicator was completed by 82 preservice agricultural education teachers. All 16 types were reflected; the most common were Extrovert Sensing Thinking Judging (23%), Introvert Sensing Thinking Judging (18%), and Extrovert Sensing Feeling Judging (13%). (SK)

  11. Fads versus Reality: Knowing Your Students.

    ERIC Educational Resources Information Center

    Holliday, William G.

    2000-01-01

    Indicates the responsibilities of teachers in understanding the student learning process and focuses on some tools that identify student learning styles such as quizzes, the Myers Briggs Type Indicator, and Multiple Intelligences. (YDS)

  12. Unlocking Personality Type.

    ERIC Educational Resources Information Center

    Tieger, Paul D.

    2002-01-01

    This article examines some of the intricacies of personality types and their effect on career choices. Proposes that knowing students' Myers-Briggs personality types can help school counselors guide them down the right career path. (GCP)

  13. A Pilot Study of Personality Type Change.

    ERIC Educational Resources Information Center

    Johnson, Lee

    1980-01-01

    Used the Myers Briggs Type Indicator to measure personality type changes in three developmentally disabled adolescents before and after token economy treatment was conducted in a half-way house. (Author/DB)

  14. Fads versus Reality: Knowing Your Students.

    ERIC Educational Resources Information Center

    Holliday, William G.

    2000-01-01

    Indicates the responsibilities of teachers in understanding the student learning process and focuses on some tools that identify student learning styles such as quizzes, the Myers Briggs Type Indicator, and Multiple Intelligences. (YDS)

  15. Personality type and clinical evaluations in an obstetrics/gynecology medical student clerkship.

    PubMed

    Davis, Katrina R; Banken, Joseph A

    2005-11-01

    The purpose of this study was to determine whether the Myers-Briggs type inventory extraversion is associated with clinical evaluation ratings that students earn during their (obstetrics/gynecology) junior medical student clerkship. The Myers-Briggs type inventory was administered to medical students during their obstetrics/gynec clerkship. Bivariate correlations between clinical evaluations, National Board of Medical Examiners subject scores, and data from the Myers-Briggs type inventory extraversion scale were analyzed. Pearson product-moment correlation between clinical and National Board of Medical Examiners subject scores was not significant (r = .25; P = .05). The National Board of Medical Examiners did not show significant correlations with the Myers-Briggs type inventory extraversion data. The clinical evaluations showed a significant correlation (r = .35; P = .005) with Myers-Briggs type inventory extraversion. Results show that Myers-Briggs type inventory extraversion is correlated positively with clinical evaluations. The National Board of Medical Examiners subject examination and clinical evaluations were not correlated significantly. Findings question whether clinical evaluation data should be included in the obstetrics/gynecology medical student evaluation process.

  16. Update on local allergic rhinitis.

    PubMed

    Altıntoprak, Niyazi; Kar, Murat; Bayar Muluk, Nuray; Oktemer, Tugba; Ipci, Kagan; Birdane, Leman; Aricigil, Mitat; Senturk, Mehmet; Bafaqeeh, Sameer Ali; Cingi, Cemal

    2016-08-01

    We here provide an update on the literature regarding local allergic rhinitis (LAR). In reviewing LAR, we have included an updated definition, classifications, mechanisms, comorbidities, and recommendations for diagnosis and treatment for LAR, as well as the defined research areas for future evidence-based studies. LAR is a localised nasal allergic response in the absence of systemic atopy characterised by local production of specific IgE (sIgE) antibodies, a TH2 pattern of mucosal cell infiltration during natural exposure to aeroallergens, and a positive nasal allergen provocation test response, with the release of inflammatory mediators. The localised allergic response of LAR is an important topic for the study of allergies. This review provides an update on the current knowledge of LAR. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  17. Optical-Fiber Fluorosensors With Polarized Light Sources

    NASA Technical Reports Server (NTRS)

    Egalon, Claudio O.; Rogowski, Robert S.

    1995-01-01

    Chemiluminescent and/or fluorescent molecules in optical-fiber fluorosensors oriented with light-emitting dipoles along transverse axis. Sensor of proposed type captures greater fraction of chemiluminescence or fluorescence and transmits it to photodetector. Transverse polarization increases sensitivity. Basic principles of optical-fiber fluorosensors described in "Making Optical-Fiber Chemical Sensors More Sensitive" (LAR-14525), "Improved Optical-Fiber Chemical Sensors" (LAR-14607), and "Improved Optical-Fiber Temperature Sensors" (LAR-14647).

  18. Naval Research Reviews. Office of Naval Research, Volume 45, Four/1993 and Volume 46, One/1994

    DTIC Science & Technology

    1994-01-01

    that, because of the great difference between the mass of the electron and the masses of the other atomic and molecu- AG T _ ( Ao + AGO lar species in...of homogeneous bimolecu- clue to theorigin of thisdsparate behavior isprovidedby theET lar reactivity noted above. The most important difference...radius? Both of rate inversion.7 3 These experiments involved intramolecu- questions could be of importance in emerging redox-based lar ET and were

  19. Petrology and Geochemistry of New Paired Martian Meteorites Larkman Nunatak 12240 and Larkman Nunatak 12095

    NASA Technical Reports Server (NTRS)

    Funk, R. C.; Peslier, A. H.; Brandon, A. D.; Humayun, M.

    2016-01-01

    Two of the latest Martian meteorites found in Antarctica, paired olivine-phyric shergottites LAR 12240 and LAR 12095, are described in order to decipher their petrological context, and place constraints on the geological history of Mars. This project identifies all phases found in LAR 12240 and 12095 and analyzes them for major and trace elements. The textural relationships among these phases are examined in order to develop a crystallization history of the magma(s) that formed these basalts.

  20. Optical-Fiber Fluorosensors With Polarized Light Sources

    NASA Technical Reports Server (NTRS)

    Egalon, Claudio O.; Rogowski, Robert S.

    1995-01-01

    Chemiluminescent and/or fluorescent molecules in optical-fiber fluorosensors oriented with light-emitting dipoles along transverse axis. Sensor of proposed type captures greater fraction of chemiluminescence or fluorescence and transmits it to photodetector. Transverse polarization increases sensitivity. Basic principles of optical-fiber fluorosensors described in "Making Optical-Fiber Chemical Sensors More Sensitive" (LAR-14525), "Improved Optical-Fiber Chemical Sensors" (LAR-14607), and "Improved Optical-Fiber Temperature Sensors" (LAR-14647).

  1. Improving the Utility of Laryngeal Adductor Reflex Testing: A Translational Tale of Mice and Men.

    PubMed

    Shock, Leslie A; Gallemore, Brandon C; Hinkel, Cameron J; Szewczyk, Marlena M; Hopewell, Bridget L; Allen, Mitchell J; Thombs, Lori A; Lever, Teresa E

    2015-07-01

    Evaluation of the laryngeal adductor reflex (LAR) entails delivering air through an endoscope positioned 1 to 2 mm from the arytenoid mucosa to elicit bilateral vocal fold (VF) closure. This short working distance limits visualization to only the ipsilateral arytenoid and results in quantification of a single LAR metric: threshold pressure that evokes the LAR. Our goal was to evolve the LAR procedure to optimize its utility in clinical practice and translational research. Prospective translational experiment. Academic institution. Young healthy human adults (n = 13) and 3 groups of mice: healthy, primary aging mice (n = 5), a transgenic mouse model of amyotrophic lateral sclerosis (ALS; n = 4), and young healthy controls (n = 10). The VFs were visualized bilaterally during supramaximal air stimulation through an endoscope. Responses were analyzed to quantify 4 novel metrics: VF adduction phase duration, complete glottic closure duration, VF abduction phase duration, and total LAR duration. The 4 LAR metrics are remarkably similar between healthy young humans and mice. Compared to control mice, aging mice have shorter glottic closure durations, whereas ALS-affected mice have shorter VF abduction phase durations. We have established a new LAR protocol that permits quantification of novel LAR metrics that are translatable between mice and humans. Using this protocol, we showed that VF adduction is impaired in primary aging mice, whereas VF abduction is impaired in ALS-affected mice. These preliminary findings highlight the enhanced diagnostic potential of LAR testing. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2015.

  2. Cognitive and learning styles as predictors of success on the National Board Dental Examination.

    PubMed

    Behar-Horenstein, L S; Garvan, Cynthia W; Bowman, B J; Bulosan, M; Hancock, S; Johnson, M; Mutlu, B

    2011-04-01

    Using a deidentified retrospective dataset of three cohorts of matriculated dental students, we measured the degree to which selected student attributes, the Learning Type Measure, the Myers-Briggs Type Indicator, and Dental Admission Test subtests scores predicted passage on the National Board Dental Examination (NBDE), Parts I and II. Gender, Myers-Briggs Type Indicators, and the Dental Admission Test subtests for academic average and biology were found to be predictive of passing the NBDE Part I. Gender, a Myers-Briggs Type Indicator (thinking over feeling), and the Dental Admission Test subtests on reading and biology were found to be predictive of passing the NBDE Part II. The Learning Type Measure was not found to be predictive of passing the NBDE Part I or Part II. This study holds implications for heightening faculty members' awareness of students' aptitude and cognitive attributes, for teaching, and for the admissions process.

  3. Moderator variables in life stress and illness relationship.

    PubMed

    Cooley, E J; Keesey, J C

    1981-09-01

    The relationship between life stress and physical illness was examined for the effects of potential moderator variables: The Sensation-Seeking Scale, health Locus of Control Scale, and Myers-Briggs Type Indicator. The Sensation-Seeking Scale proved to be a moderator with high sensation seekers (highest quartile) showing no significant correlations between life change and illness, while low sensation seekers (lowest quartile) showed a significant correlation. The Health Locus of Control Scale failed to differentiate between correlation levels for Internals and Externals. The Myers-Briggs provided several moderator variables. Introverts, Thinking and Sensing types showed larger correlations than their Extrovert, Feeling and Intuitive counterparts. The magnitudes and significance levels of these correlations suggest that the Myers-Briggs may have further usefulness in exploring the relationship between life change and illness.

  4. Interaction of psychological type and anxiety sensitivity on academic achievement.

    PubMed

    Nyland, J L; Ybarra, K M; Sammut, K L; Rienecker, E M; Kameda, D M

    2000-06-01

    The Myers-Briggs Type Indicator and the Anxiety Sensitivity Index were administered to 143 undergraduate college students. Analyses of variance were performed to assess the relationship between these indices and semester grades (Grade Point Average). The Myers-Briggs Sensing-Intuitive and Judging-Perceiving dimensions showed significant main effects on GPA. The interaction of Judging-Perceiving and Anxiety Sensitivity was also significant (F = 18.00, p<.0001), although that of Sensing-Intuition and Anxiety Sensitivity was not (F = 3.51, p=.06). These findings suggest that personality factors measured by the Myers-Briggs Type Indicator may serve as mediating variables in evaluating whether trait anxiety has a facilitating or debilitating effect on academic achievement.

  5. Prevention of diet-induced obesity by safflower oil: insights at the levels of PPARalpha, orexin, and ghrelin gene expression of adipocytes in mice.

    PubMed

    Zhang, Zhong; Li, Qiang; Liu, Fengchen; Sun, Yuqian; Zhang, Jinchao

    2010-03-15

    The aim of this study was to investigate the prevention of diet-induced obesity by a high safflower oil diet and adipocytic gene expression in mice. Forty 3-week-old C57BL/6 mice were randomly divided into three groups: control group (CON, 5% lard + 5% safflower oil), high lard group (LAR, 45% lard + 5% safflower oil), and high safflower oil group (SAF, 45% safflower oil + 5% lard). After 10 weeks, 10 mice of the LAR group were switched to high safflower oil diet (LAR-SAF). Ten weeks later, glucose tolerance tests were performed by intraperitoneal injection of glucose. Circulating levels of lipid and insulin were measured and white adipose tissues were taken for gene chip and reverse transcriptase-polymerase chain reaction analysis. The LAR group showed higher body weight, adiposity index, insulin, and lipids than the CON group (P<0.05). The body weight in the LAR-SAF group decreased after dietary reversal. The plasma biochemical profiles decreased in the LAR-SAF and SAF groups (P<0.05) compared with those of the LAR group. The blood glucose level of the LAR-SAF group was reduced during intraperitoneal glucose tolerance test compared with that of the LAR group. The LAR-SAF group had lower levels of Orexin and Ghrelin gene expression, whereas the level of PPARalpha gene expression was significantly enhanced compared with that of the LAR group. So, the SAF diet can alter adipocytic adiposity-related gene expression and result in effective amelioration of diet-induced obesity.

  6. Sediment Particle Characterization for Acoustic Applications: Coarse Content, Size and Shape Distributions in a Shelly Sand/Mud Environment

    DTIC Science & Technology

    2009-03-31

    Sedimentology , 55, pp.31-63. [15] E.I. Thorsos, K.L. Williams, D. Tang and S.G. Kargl (2005), “SAX04 overview”, in, Boundary Influences in High...Briggs, and A.H. Reed (2005), “Using CT to image storm-generated stratigraphy in sandy sediment off Fort Walton Beach, Florida, USA”, in, Proceedings of...K.B. Briggs, A.H. Reed, D.R. Jackson, and D. Tang (2010), “Fine-scale volume heterogeneity in storm-generated stratigraphy in sandy sediment off

  7. Stabilizing Effect of Gas Conductivity Evolution on the Resistive Sausage Mode of a Propagating Beam

    DTIC Science & Technology

    1983-06-08

    and S. Yu, "Model of Emittance Growth in a Self-Pinched Beam," Lawrence Livermore Laboratory Report UCID-18330 (1979). 18. J. C. Clark, T. J. Fessenden ...and K. W. Struve, Bull. Am. Phys. Soc. 27, 1133 (1982). 19. R. J. Briggs, D. L. Birx, G. J. Caporaso, T. J. Fessenden , R. E. Hester, V fR. Melendez...V. K. Neil, A. C. Paul, and K. W. Struve, IEEE Trans. Nucl. Sci. NS-28, 3360 (1981). 23 20. E. J. Lauer, R. J. Briggs, T. J. Fessenden , R. E. Rester

  8. The new Adelaide medium frequency Doppler radar

    NASA Astrophysics Data System (ADS)

    Reid, I. M.; Vandepeer, B. G. W.; Dillon, S.; Fuller, B.

    1993-08-01

    The Buckland Park Aerial Array (35 deg S, 138 deg E) is situated about 40 km north of Adelaide on a flat coastal plain. It was designed by Basil Briggs and Graham Elford, and constructed between 1965 and 1968. The first results were published in the late 1960's. Some aspects of the history of the array are described in Briggs (1993). A new MF Doppler Radar utilizing the array has been developed. This paper describes some of the technical details of this new facility.

  9. Preceptors and new graduate nurse orientees: implications of psychological type compatibility.

    PubMed

    Poradzisz, Michele; Kostovich, Carol T; O'Connell, Debbie; Lefaiver, Cheryl A

    2012-01-01

    The relationship between preceptor and new graduate nurse (NGN) orientee can be a critical factor in NGNs' satisfaction with choice of profession and place of employment. A research study was conducted with NGN orientees (n = 218) and preceptors (n = 159) to investigate characteristics of psychological type as determined by the Myers-Briggs Type Indicator. Preliminary descriptive data regarding participants' Myers-Briggs Type Indicator characteristics is presented, and suggestions are offered for working with orientees during orientation in both classroom sessions and clinical units.

  10. 77 FR 54933 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    ....: LAR-17485-2: Metal/Fiber Laminate and Fabrication Using a Porous Metal/Fiber Preform; NASA Case No...: Wireless Temperature Sensor Having No Electrical Connections and Sensing Method for Use Therewith; NASA... Piezoelectric Stacks; NASA Case No.: LAR-17455-2: A Nanotube Film Electrode and an Electroactive Device...

  11. 75 FR 28663 - Government-Owned Inventions, Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-21

    ... Deflection to Control an Electron Beam Wire. NASA Case No.: LAR-17286-1: Miniature, Low-Power X-Ray Tube Using a Microchannel Electron Generator Electron Source. NASA Case No.: LAR-17413-2: Nanoparticle...-1: Closed-Loop Process Control for Electron Beam Freeform Fabrication and Deposition Processes....

  12. 78 FR 14817 - Endangered Species; Receipt of Applications for Permit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-07

    ...), mandrill (Mandrillus sphinx), lar gibbon (Hylobates lar), leopard (Panthera pardus), snow leopard (Uncia... wildlife registration under 50 CFR 17.21(g) to include leopard (Panthera pardus), snow leopard (Uncia uncia... langur (Semnopithecus entellus) Mandrill (Mandrillus sphinx) African wild dog (Lycaon pictus) Snow...

  13. Molecular characterization of genes encoding leucoanthocyanidin reductase involved in proanthocyanidin biosynthesis in apple

    PubMed Central

    Liao, Liao; Vimolmangkang, Sornkanok; Wei, Guochao; Zhou, Hui; Korban, Schuyler S.; Han, Yuepeng

    2015-01-01

    Proanthocyanidins (PAs) are the major component of phenolics in apple, but mechanisms involved in PA biosynthesis remain unclear. Here, the relationship between the PA biosynthesis and the expression of genes encoding leucoanthocyanidin reductase (LAR) and anthocyanidin reductase (ANR) was investigated in fruit skin of one apple cultivar and three crabapples. Transcript levels of LAR1 and ANR2 genes were significantly correlated with the contents of catechin and epicatechin, respectively, which suggests their active roles in PA synthesis. Surprisingly, transcript levels for both LAR1 and LAR2 genes were almost undetectable in two crabapples that accumulated both flavan-3-ols and PAs. This contradicts the previous finding that LAR1 gene is a strong candidate regulating the accumulation of metabolites such as epicatechin and PAs in apple. Ectopic expression of apple MdLAR1 gene in tobacco suppresses expression of the late genes in anthocyanin biosynthetic pathway, resulting in loss of anthocyanin in flowers. Interestingly, a decrease in PA biosynthesis was also observed in flowers of transgenic tobacco plants overexpressing the MdLAR1 gene, which could be attributed to decreased expression of both the NtANR1 and NtANR2 genes. Our study not only confirms the in vivo function of apple LAR1 gene, but it is also helpful for understanding the mechanism of PA biosynthesis. PMID:25914714

  14. The "Journal of Learning Analytics": Supporting and Promoting Learning Analytics Research

    ERIC Educational Resources Information Center

    Siemens, George

    2014-01-01

    The paper gives a brief overview of the main activities for the development of the emerging field of learning analytics led by the Society for Learning Analytics Research (SoLAR). The place of the "Journal of Learning Analytics" is identified. Analytics is the most significant new initiative of SoLAR.

  15. The Need For and Benefits of the Creation of the Light Armored Reconnaissance Regiment

    DTIC Science & Technology

    2010-04-14

    the Marine Personnel Carrier will require the funding to build new maintenance ramps, infrastructure, and barracks aboard Camp Pendleton and Camp ... Lejuene . In m’der to facilitate the creation of the LAR Regiment and the creation of the LAR TECOE, it is proposed that the MPC units inherent the

  16. Sustained release octreotide may have a role in the treatment of malignant bowel obstruction.

    PubMed

    Massacesi, Cristian; Galeazzi, Giordano

    2006-10-01

    Daily or continuous infusion octreotide is effective in relieving the gastrointestinal symptoms associated with inoperable malignant bowel obstruction (MBO). The sustained release (LAR) formulation of octreotide provides sustained exposure of the drug. This preliminary study aimed to investigate the efficacy of octreotide LAR (20 mg) for reducing gastrointestinal symptoms or nasogastric tube (NGT) secretions in patients with MBO. In patients with NGT (n = 8), octreotide LAR reduced NGT secretions from day one onwards, and NGT was removed in one patient. In patients without NGT (n = 4), octreotide LAR reduced episodes of vomiting and the severity of nausea, and this reduction was maintained throughout the study. Tolerability was good. In conclusion, the more convenient dosing schedule and potential activity of octreotide LAR may have a role in controlling MBO symptoms, and, therefore, it deserves further studies.

  17. Robotic Versus Laparoscopic Surgery for Rectal Cancer after Preoperative Chemoradiotherapy: Case-Matched Study of Short-Term Outcomes

    PubMed Central

    Kim, Yong Sok; Kim, Min Jung; Park, Sung Chan; Sohn, Dae Kyung; Kim, Dae Yong; Chang, Hee Jin; Nam, Byung-Ho; Oh, Jae Hwan

    2016-01-01

    Purpose Robotic surgery is expected to have advantages over laparoscopic surgery; however, there are limited data regarding the feasibility of robotic surgery for rectal cancer after preoperative chemoradiotherapy (CRT). Therefore, we evaluated the short-term outcomes of robotic surgery for rectal cancer. Materials and Methods Thirty-three patients with cT3N0-2 rectal cancer after preoperative CRT who underwent robotic low anterior resection (R-LAR) between March 2010 and January 2012 were matched with 66 patients undergoing laparoscopic low anterior resection (L-LAR). Perioperative clinical outcomes and pathological data were compared between the two groups. Results Patient characteristics did not differ significantly different between groups. The mean operation time was 441 minutes (R-LAR) versus 277 minutes (L-LAR, p < 0.001). The open conversion rate was 6.1% in the R-LAR group and 0% in the L-LAR group (p=0.11). There were no significant differences in the time to flatus passage, length of hospital stay, and postoperative morbidity. In pathological review, the mean number of harvested lymph nodes was 22.3 in R-LAR and 21.6 in L-LAR (p=0.82). Involvement of circumferential resection margin was positive in 16.1% and 6.7%, respectively (p=0.42). Total mesorectal excision (TME) quality was complete in 97.0% in R-LAR and 91.0% in L-LAR (p=0.41). Conclusion In our study, short-term outcomes of robotic surgery for rectal cancer after CRT were similar to those of laparoscopic surgery in respect to bowel function recovery, morbidity, and TME quality. Well-designed clinical trials are needed to evaluate the functional results and long-term outcomes of robotic surgery for rectal cancer. PMID:25779367

  18. Nonparametric Regression Subject to a Given Number of Local Extreme Value

    DTIC Science & Technology

    2001-07-01

    Universitdit Essen, 1997. 8. Jorge Nocedal and Stephen J. Wright. Numerical Optimization. Springer, Berlin, 1999. 9. Gerardo Toraldo and Jorge J. Mor&. On...proved by L6wendick [6]. El Bibliography 1. William L. Briggs. A Multigrid Tutorial. SIAM, New York, 1994. 2. Paul H. Calamai and Jorge J. Mor6

  19. Robbing Peter to pay Paul.

    PubMed

    Briggs, P

    1979-10-05

    Cutbacks in the health service are already affecting recruitment. Employing authorities are facing the problem of reducing expenditure and this will, inevitably lead to a reappraisal of decisions to employ locums. Peter Briggs, area medical officer for Hillingdon, discusses the implications and looks at the situation in the London area.

  20. 77 FR 43582 - Agency Information Collection Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-25

    ... information collection request to the OMB for an extension under the provisions of the Paperwork Reduction Act... Street NW., Washington, DC 20503, and to Felecia Briggs, U.S. Department of Energy, Office of Health, Safety and Security, HS-83/C-412, 1000 Independence Ave. SW., Washington, DC 20585-1290, (301)...

  1. Boys and CSA Prevention: Issues Surrounding Gender and Approaches for Prevention

    ERIC Educational Resources Information Center

    Scholes, Laura; Jones, Christian; Nagel, Michael

    2014-01-01

    Freda Briggs (2007), a leader in the field of child protection in Australia continues to raise concerns about the vulnerability and victimisation of boys that she believes is substantially under-recognised. She argues that boys have not been well supported by child sexual abuse (CSA) prevention programs with child protection curriculum not yet…

  2. Correlation between Leadership Effectiveness and Personality Preferences at a Hungarian Independent Financial Advisor Company

    ERIC Educational Resources Information Center

    Mészáros, Aranka; Budavári-Takács, Ildikó

    2016-01-01

    The main focus of our research is to study, with the help of the dimensions of the Myers-Briggs Type Indicator (hereinafter: MBTI) the personality preferences of those leaders at the financial advisor company who are successful already. In the present study first we introduce the preferences of MBTI. Then we go on to define our hypothesis…

  3. Use of the MBTI as a Predictor of Successful Academic and Military Performance at the United States Coast Guard Academy. Report 10-93.

    ERIC Educational Resources Information Center

    O'Connor, John C., III

    This study provides an analysis of a random sample of 100 cadets from the United States Coast Guard Academy class of 1993. Emphasis is placed on the cadets' academic achievements, their military performance, and their resignation status to determine whether the Myers-Briggs Type Indicator (MBTI) preferences can be used to predict success in these…

  4. Correlation between Leadership Effectiveness and Personality Preferences at a Hungarian Independent Financial Advisor Company

    ERIC Educational Resources Information Center

    Mészáros, Aranka; Budavári-Takács, Ildikó

    2016-01-01

    The main focus of our research is to study, with the help of the dimensions of the Myers-Briggs Type Indicator (hereinafter: MBTI) the personality preferences of those leaders at the financial advisor company who are successful already. In the present study first we introduce the preferences of MBTI. Then we go on to define our hypothesis…

  5. Learning Progressions, Vertical Scales, and Testable Hypotheses: Promising Intuitions and Points for Clarification

    ERIC Educational Resources Information Center

    Maul, Andrew

    2015-01-01

    Briggs and Peck [in "Using Learning Progressions to Design Vertical Scales That Support Coherent Inferences about Student Growth"] call for greater care in the conceptualization of the target attributes of students, or "what it is that is growing from grade to grade." In particular, they argue that learning progressions can…

  6. Balancing the Need for Reliability and Time Efficiency: Short Forms of the Wechsler Adult Intelligence Scale-III

    ERIC Educational Resources Information Center

    Jeyakumar, Sharon L. E.; Warriner, Erin M.; Raval, Vaishali V.; Ahmad, Saadia A.

    2004-01-01

    Tables permitting the conversion of short-form composite scores to full-scale IQ estimates have been published for previous editions of the Wechsler Adult Intelligence Scale (WAIS). Equivalent tables are now needed for selected subtests of the WAIS-III. This article used Tellegen and Briggs's formulae to convert the sum of scaled scores for four…

  7. Holland Vocational Personality Codes and People with Visual Disabilities: A Need for Caution.

    ERIC Educational Resources Information Center

    Jones, W. Paul

    1995-01-01

    This study compared scores of adults (n=34) with blindness and sighted individuals on the Holland Vocational Preference Inventory (VPI) and the Myers-Briggs Type Indicator (MBTI). Findings indicated a higher incidence of unusual vocational codes selected by people with visual disabilities on the VPI and few differences between visually impaired…

  8. Temperament-Based Learning Styles of Palestinian and US Children

    ERIC Educational Resources Information Center

    Oakland, Thomas; Alghorani, Mohammed Adnan; Lee, Dong Hun

    2007-01-01

    Temperament styles of 400 Palestinian children living in Gaza are described, examined for possible gender and age differences, and compared with those of 3,200 US children in light of Jung's theory of temperament as modified by Myers and Briggs. The results show that Palestinian children generally prefer practical to imaginative, feeling to…

  9. Temperament Styles of Children in South Korea and the United States

    ERIC Educational Resources Information Center

    Lee, Dong Hun; Oakland, Thomas; Ahn, Changgu

    2010-01-01

    Temperament styles of 4,628 South Korean children, ages 9-17, are described in reference to possible gender and age differences and compared with those of 3,200 US age peers in the light of Jung's theory of temperament as modified by Myers and Briggs, one that highlights four bipolar qualities: extroversion-introversion, practical-imaginative,…

  10. Linking Learning Style Theory with Retention Research: The TRAILS Project. AIR 1986 Annual Forum Paper.

    ERIC Educational Resources Information Center

    Kalsbeek, David H.

    The Myers-Briggs Type Indicator (MBTI), a measure of personality type and learning style, was used at Saint Louis University in the TRAILS (Tracking Retention and Academic Integration by Learning Style) Project. In addition to considering links between learning styles and student academic achievement and aptitude, MBTI was used to identify…

  11. Selection and Assessment of Special Forces Qualification Course Candidates: Preliminary Issues

    DTIC Science & Technology

    1988-04-01

    judge things, people, events, or ideas. Perception and judgment are assessed through four bipolar dimensions: extraversion - introversion , E-I (reflects...order: Wonderlic Personnel Test , Jackson Personality Inventory, Myers-Briggs Type Indicator, and the Biographical questionnaire. Total administration...Physical Fitness . . . . . . .. .. .. .. .. .. .. .. .. .. .. 6 Intelligence .. .. ....... ...... ....... ....... 6 Personality

  12. Learning Style Preferences of Native American and African-American Secondary Students as Measured by the MBTI.

    ERIC Educational Resources Information Center

    Nuby, Jacqueline F.; Oxford, Rebecca L.

    The Myers Briggs Type Indicator (MBTI) was used to identify simililarities and significant differences in the learning style preferences of secondary students from two cultures. A second purpose of the study was to identify gender differences in learning style within and across these two cultures. A total of 103 African Americans from a high…

  13. The Singer-Loomis Inventory of Personality: A Review and Critique.

    ERIC Educational Resources Information Center

    Shou, Priscilla

    The Singer-Loomis Inventory of Personality (SLIP) was developed by two Jungian analysts to allow examination of personality from the perspective of Jung's typology and to solve problems perceived with the Myers-Briggs Type Indicator, based on Jungian dichotomies. The SLIP is designed to clarify and describe the user's personality based on the…

  14. Overview of the Taxonomy of Environmental Types and the Factor Structure of the Salter Environmental Type Assessment.

    ERIC Educational Resources Information Center

    Salter, Daniel W.; Vandiver, Beverly J.

    2002-01-01

    The Salter Environmental Type Assessment (SETA) was created to be a commensurate measure for the Myers-Briggs Type Indicator and to improve the efficacy of the person-environmental interaction paradigm to student affairs. A confirmatory factor analysis of SETA profiles supported the four dimensions in environmental type theory. The utility of this…

  15. A Generalizability Study of Salter Environmental Type Assessment Scores by Social Climate Domain.

    ERIC Educational Resources Information Center

    Walter, Daniel W.

    2003-01-01

    The Salter Environmental Type Assessment- Experimental Form B (SETA-Form B) was designed to be a commensurate environmental assessment for the Myers-Briggs Type Indicator. This study addressed the generalizability of the SETA-Form B scores provided by 800 college students across 4 environmental domains. Although the results were mostly positive,…

  16. Effects of Computer-Based Test Administrations on Test Anxiety and Performance.

    ERIC Educational Resources Information Center

    Shermis, Mark D.; Lombard, Danielle

    1998-01-01

    Examines the degree to which computer and test anxiety have a predictive role in performance across three computer-administered placement tests. Subjects (72 undergraduate students) were measured with the Computer Anxiety Rating Scale, the Test Anxiety Inventory, and the Myers-Briggs Type Indicator. Results suggest that much of what is considered…

  17. 78 FR 42804 - SST Truck Company, LLC, a Navistar, Inc. Company Including On-Site Leased Workers From Employee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-17

    ... Business Machines (IBM), Akzo Nobel, US Security, ASF Logistics, LLC, Briggs Equipment, William Thomas... reports that workers leased from Encore, International Business Machines (IBM), Akzo Nobel, US Security... include workers leased from Encore, International Business Machines (IBM), Akzo Nobel, US Security, ASF...

  18. The Maryland Career Course: Type/Learning Style Issues. Brief Report #2.

    ERIC Educational Resources Information Center

    Moore, William S.

    The Maryland career course is a one-credit career planning course for undecided undergraduates which has provided training for teaching apprentices, and research on students' career decision making. To investigate typology differences in the population enrolling in the course, the Strong-Campbell Interest Inventory (SCII) and the Myers-Briggs Type…

  19. Relationship of Personality Traits to Student Retention

    ERIC Educational Resources Information Center

    Liang, John Paul

    2010-01-01

    Carl Jung's theory of psychological types has been the basis for the development of personality categorization, including tests such as Myers-Briggs Type Indicator (MBTI). This study analyzed the extent of the relationship between MBTI and Tinto (1993) retention factors that influence Oriental medicine students' choice of staying or dropping out…

  20. A Comparison of Osteopathic, Pharmacy, Physical Therapy, Physician Assistant and Occupational Therapy Students' Personality Styles: Implications for Education and Practice.

    ERIC Educational Resources Information Center

    Hardigan, Patrick C.; Cohen, Stanley R.

    This study compared personality traits of students in five health professions. The Myers-Briggs Type Indicator was completed by 1,508 osteopathic students, 654 pharmacy students, 165 physical therapy students, 211 physician assistant students, and 70 occupational therapy students. Comparing the extrovert/introvert dimension revealed that pharmacy…

  1. Personality Trait and Professional Choice among Preservice Teachers in Eastern Kentucky.

    ERIC Educational Resources Information Center

    Hinton, Samuel; Stockburger, Muriel

    A preliminary study was conducted to examine indicators which tend to reflect relationships between personality traits and professional choice among elementary education students enrolled in the teacher education program in Eastern Kentucky University. Education students in elementary education (N=122) completed the Myers Briggs Type Indicator.…

  2. Investigation of the Relationships Between Personality Types of Eighth-Grade Science Students and Cognitive Preference Orientation.

    ERIC Educational Resources Information Center

    Novak, John Anthony

    This study investigated the relationship among personality types, cognitive preference orientation, science achievement, intelligence, attitudes toward science and scientists, sex, and geographic area of eighth-grade science students using the following four instruments: (1) Myers-Briggs Type Indication (MBTI); (2) Cognitive Preference Examination…

  3. An Examination of Preferences for Social Presence in Online Courses with Regard to Personality Type

    ERIC Educational Resources Information Center

    Rose, Daniel Merritt

    2012-01-01

    The purpose of this research was to examine the connections between personality types as illustrated by the Myers Briggs Type Indicator and the desire for social presence components within a technology based learning environment. Participants in the study were undergraduate and graduate students enrolled in an educational technology program at a…

  4. Personality Types and Learners' Interaction in Web-Based Threaded Discussion

    ERIC Educational Resources Information Center

    Lee, JeongMin; Lee, Youngmin

    2006-01-01

    This study examined the effects of group composition based on the learners' personality types as measured by the Myers-Briggs type indicator as they interacted in threaded discussions. Three groups comprised introverts, extroverts, and mixed introvert-extrovert classifications. Ninety-six participants were divided into 24 groups of 4 participants…

  5. Examination of Psychological Type and Preferred Negotiation Tactics and Strategies of Contract Negotiators

    DTIC Science & Technology

    1992-09-01

    16 Jung’s Theory of Psychological Types ............. 16 Personality Type Theory ....................... 17 Perception...noted psychologist Carl G. Jung published the book Psychological Types. Within this publication, Jung detailed his theory of personality types which...Jung. Myers and Briggs expanded Jung’s psychological type theory by adding an attitude preference which will again double the number of personality

  6. An Examination of Self-Directed Learning Readiness in Executive-Level Fire Officers

    ERIC Educational Resources Information Center

    Knight, Steven G.

    2012-01-01

    The purpose of this study was to examine the self-directed learning readiness in executive fire officers in relation to the independent variables of personality type, educational attainment, and professional designation. This research utilized a quantitative design. This study utilized the Myers-Briggs Type Indicator (MBTI) and the Self-Directed…

  7. Personality Traits of Graduate Counseling Students as Compared to Education Administration/Supervision Students.

    ERIC Educational Resources Information Center

    Ledyard, Pat

    This research study describes results of a survey developed from the Sixteen Personality Factor Questionnaire and the Myers-Briggs Type Indicators and administered to 45 graduate students, including both counseling and education administration students. Previous research suggested that there were specific personality traits for counselor…

  8. The Role of Personality Temperament and Student Learning in Principles of Economics: Further Evidence.

    ERIC Educational Resources Information Center

    Ziegert, Andrea L.

    2000-01-01

    Explores the relationship between student personality types and measures of student performance in principles of microeconomics using the Keirsey Sorter, a 70-question Myers-Briggs Type Indicator (MBTI); results from the Test of Understanding of College Economics (TUCE); and course grades. Suggests that personality types do affect student…

  9. Consistency between Learning Style Patterns and Teaching Style Behaviors of Prospective Elementary Teachers.

    ERIC Educational Resources Information Center

    Lyons, Carol A.

    A followup study was made of a previous investigation of the learning and teaching style of preservice elementary school teachers. In the original study, 20 female education majors were given the Myers-Briggs Type Indicator (MBTI) test to determine individual dominant personality types. The portable Rod and Frame Test, the Group Embedded Figures…

  10. Creativity and Intuition Revisited

    ERIC Educational Resources Information Center

    Dollinger, Stephen J.; Palaskonis, Dimitra G.; Pearson, Jodi L.

    2004-01-01

    This study used the recently revised Myers Briggs Type Indicator (MBTI) and a variety of validated creativity measures to replicate a classic finding--that sensing-intuition predicts creativity--and to evaluate whether the other MBTI scales add to the prediction of creativity. 94 undergraduates completed the MBTI (form M self-scorable) and…

  11. Access Education Literature with ERIC on CD-ROM: An Introductory Workshop.

    ERIC Educational Resources Information Center

    Roberts, Deanna

    This report provides instructional materials for a voluntary introductory workshop in the use of the Educational Resources and Information Clearinghouse (ERIC) database on CD-ROM. The workshop instruction is based on Leslie J. Brigg's Theories of Instructional Design with instructional objectives based on Robert Gagne's Learning Taxonomy. Library…

  12. The Scholarly Process: A Grounded Theory Exploring How Counselor Educators Promote Scholarship of Counselors-in-Training

    ERIC Educational Resources Information Center

    Michalak, Megan B.

    2013-01-01

    The demand for master's level counseling scholarship is on the rise as a call for evidenced based practices persist (Benishek, 1998; Briggs & Pehrsson, 2008; Huber & Savage, 2009). Although there is a demand to increase the amount of counseling produced scholarship, little examination exists regarding how the profession can begin to…

  13. Punk Rock Fish: Applying a Conceptual Framework of Simulations in a High School Science Classroom

    ERIC Educational Resources Information Center

    Helms, Samuel

    2009-01-01

    Like other learning tools, simulations benefit from an instructional context. To use Gagne and Briggs' model as an example, the learner should first be reminded of the prerequisite learnings, informed of the objectives, and his/her attention gained before being presented with the learning material. Research regarding simulations in education…

  14. The Effects of Iconic Presentation on Individuals

    DTIC Science & Technology

    1992-09-01

    attitudes (Davis, 1981; Lusk and Dersnick, 1979; Robey, 1983; Zmud, Blocher, and Moffie , 1983). Davis (1981) performed a study based on the Myers-Briggs...Cheshire CT: Graphics Press, 1983. Zmud, R. W., E. Blocher, and R. P. Moffie . "The Impact of Color Graphic Report Formats on Decision Performance and

  15. Report of the President’s Task Force on Aircraft Crew Complement

    DTIC Science & Technology

    1981-07-02

    be heard at Manh 5, ,481 ’he iex, of thu Presid(,nt’s hearing should send a request to the the hearings and to schedule the order Me mnuindrm...and Sex on Group Performance and Member Reactions, Journal of Personality and Social Psychology, 1978, 36, 1224-1240. Briggs, G.E., and Naylor, J.C

  16. The Relationship of Personality-Based Learning Style Preferences and Learning among Online Graduate Students

    ERIC Educational Resources Information Center

    Rovai, Alfred P.; Grooms, Linda D.

    2004-01-01

    The purpose of this study was to examine the relationship of personality-based learning styles and learning among graduate students enrolled in an online doctoral program that utilized the Blackboard[SM] e-learning system. Two measures of learning--course grades and perceived learning--were used. According to the Myers-Briggs Type Indicator[R],…

  17. Personality Types of Hong Kong Kindergarten Teachers: Implications for Teacher Education

    ERIC Educational Resources Information Center

    Wong, Yau-ho Paul; Li-fang, Zhang

    2013-01-01

    While an individual's personality is related to his or her well-being, little research has examined kindergarten teachers' personality. This research was the first to investigate Hong Kong kindergarten teachers' personality types using the Myers-Briggs Type Indicator (MBTI). Three hundred and seventy-one kindergarten teachers voluntarily responded…

  18. Section 1. Career Transition for Attorneys.

    ERIC Educational Resources Information Center

    Byers, Mark; And Others

    1996-01-01

    This section on career transition for attorneys discusses career choice and satisfaction; lawyers as outplacement clients; lawyers' career concerns; Myers-Briggs type preference of lawyers and career counselors; career assessment tools and resources; lawyers and contract work; and helping lawyers change their jobs without changing employers. (JOW)

  19. A Generalizability Study of Salter Environmental Type Assessment Scores by Social Climate Domain.

    ERIC Educational Resources Information Center

    Walter, Daniel W.

    2003-01-01

    The Salter Environmental Type Assessment- Experimental Form B (SETA-Form B) was designed to be a commensurate environmental assessment for the Myers-Briggs Type Indicator. This study addressed the generalizability of the SETA-Form B scores provided by 800 college students across 4 environmental domains. Although the results were mostly positive,…

  20. Overview of the Taxonomy of Environmental Types and the Factor Structure of the Salter Environmental Type Assessment.

    ERIC Educational Resources Information Center

    Salter, Daniel W.; Vandiver, Beverly J.

    2002-01-01

    The Salter Environmental Type Assessment (SETA) was created to be a commensurate measure for the Myers-Briggs Type Indicator and to improve the efficacy of the person-environmental interaction paradigm to student affairs. A confirmatory factor analysis of SETA profiles supported the four dimensions in environmental type theory. The utility of this…