Clinical heterogeneity of patients with complex sleep apnea syndrome.

PubMed

Kuźniar, Tomasz J; Kasibowska-Kuźniar, Kamilla; Ray, Daniel W; Freedom, Thomas

2013-12-01

The definition of complex sleep apnea (CompSAS) encompasses patients with obstructive sleep apnea (OSA) who develop central apnea activity upon restitution of airway patency. Presence of arterial hypertension (HTN), coronary artery disease (CAD) and heart failure (HF) have been proposed as risk factors for CompSAS among OSA patients. Using our database of patients with CompSAS, we examined the prevalence of these risk factors and defined other clinical characteristics of patients with CompSAS. Through retrospective search of the database, we examined the medical and clinical characteristics of consecutive patients diagnosed with CompSAS between 11/1/2006 and 6/30/2011 at NorthShore University HealthSystem. One hundred and fifty patients with CompSAS were identified. Among patients included in the study, 97 (64.7 %) had at least one risk factor for CompSAS, while 53 (35.3 %) did not have any of them. Prevalence of low left ventricular ejection fraction and hypocapnia were low. Therapeutic interventions consisted of several positive airway pressure therapies, mainly adaptive servo ventilation. A hundred and ten patients (73.3 %) complied with recommended therapy and improved clinically. Although most patients with CompSAS have cardiac comorbidities, about one third of patients do not have any risk factors of CompSAS prior to sleep testing. Further research on factors involved in development of CompSAS will allow for better tailoring of therapy to pathophysiology involved in an individual case.

The EPA CompTox Chemistry Dashboard - an online resource ...

EPA Pesticide Factsheets

The U.S. Environmental Protection Agency (EPA) Computational Toxicology Program integrates advances in biology, chemistry, and computer science to help prioritize chemicals for further research based on potential human health risks. This work involves computational and data driven approaches that integrate chemistry, exposure and biological data. As an outcome of these efforts the National Center for Computational Toxicology (NCCT) has measured, assembled and delivered an enormous quantity and diversity of data for the environmental sciences including high-throughput in vitro screening data, in vivo and functional use data, exposure models and chemical databases with associated properties. A series of software applications and databases have been produced over the past decade to deliver these data. Recent work has focused on the development of a new architecture that assembles the resources into a single platform. With a focus on delivering access to Open Data streams, web service integration accessibility and a user-friendly web application the CompTox Dashboard provides access to data associated with ~720,000 chemical substances. These data include research data in the form of bioassay screening data associated with the ToxCast program, experimental and predicted physicochemical properties, product and functional use information and related data of value to environmental scientists. This presentation will provide an overview of the CompTox Dashboard and its va

Immunolocalization of Collagens (I and III) and Cartilage Oligomeric Matrix Protein in the Normal and Injured Equine Superficial Digital Flexor Tendon

PubMed Central

2013-01-01

This is a descriptive study of tendon pathology with different structural appearances of repair tissue correlated to immunolocalization of cartilage oligomeric matrix protein (COMP) and type I and III collagens and expression of COMP mRNA. The material consists of nine tendons from seven horses (5–25 years old; mean age of 10 years) with clinical tendinopathy and three normal tendons from horses (3, 3, and 13 years old) euthanized for non-orthopedic reasons. The injured tendons displayed different repair-tissue appearances with organized and disorganized fibroblastic regions as well as areas of necrosis. The normal tendons presented distinct immunoreactivity for COMP and expression of COMP mRNA and type I collagen in the normal aligned fiber structures, but no immunolabeling of type III collagen. However, immunoreactivity for type III collagen was present in the endotenon surrounding the fiber bundles, where no expression of COMP could be seen. Immunostaining for type I and III collagens was present in all of the pathologic regions indicating repair tissue. Interestingly, the granulation tissues showed immunostaining for COMP and expression of COMP mRNA, indicating a role for COMP in repair and remodeling of the tendon after fiber degeneration and rupture. The present results suggest that not only type III collagen but also COMP is involved in the repair and remodeling processes of the tendon. PMID:23020676

CARTILAGE OLIGOMERIC MATRIX PROTEIN ENHANCES MATRIX ASSEMBLY DURING CHONDROGENESIS OF HUMAN MESENCHYMAL STEM CELLS

PubMed Central

Haleem-Smith, Hana; Calderon, Raul; Song, Yingjie; Tuan, Rocky S.; Chen, Faye H.

2011-01-01

Cartilage oligomeric matrix protein/thrombospondin-5 (COMP/TSP5) is an abundant cartilage extracellular matrix (ECM) protein that interacts with major cartilage ECM components, including aggrecan and collagens. To test our hypothesis that COMP/TSP5 functions in the assembly of the ECM during cartilage morphogenesis, we have employed mesenchymal stem cell (MSC) chondrogenesis in vitro as a model to examine the effects of COMP over-expression on neo-cartilage formation. Human bone marrow-derived MSCs were transfected with either full-length COMP cDNA or control plasmid, followed by chondrogenic induction in three-dimensional pellet or alginate-hydrogel culture. MSC chondrogenesis and ECM production was estimated based on quantitation of sulfated glycosaminoglycan (sGAG) accumulation, immunohistochemistry of the presence and distribution of cartilage ECM proteins, and real-time RT-PCR analyis of mRNA expression of cartilage markers. Our results showed that COMP over-expression resulted in increased total sGAG content during the early phase of MSC chondrogenesis, and increased immuno-detectable levels of aggrecan and collagen type II in the ECM of COMP-transfected pellet and alginate cultures, indicating more abundant cartilaginous matrix. COMP transfection did not significantly increase the transcript levels of the early chondrogenic marker, Sox9, or aggrecan, suggesting that enhancement of MSC cartilage ECM was effected at post-transcriptional levels. These findings strongly suggest that COMP functions in mesenchymal chondrogenesis by enhancing cartilage ECM organization and assembly. The action of COMP is most likely mediated not via direct changes in cartilage matrix gene expression but via interactions of COMP with other cartilage ECM proteins, such as aggrecan and collagens, that result in enhanced assembly and retention. PMID:22095699

X-ray radiographic measurements of falling beads in thermally heated Comp B

NASA Astrophysics Data System (ADS)

Suvorova, Natalya; Remelius, Dennis; Oschwald, David; Smilowitz, Laura; Henson, Bryan; Davis, Stephen; Zerkle, David

2017-06-01

We have studied the behavior of Composition B under thermal heating conditions. Comp B formulation has complex thermal behavior due to the combination of 40% low melting point TNT and 60% RDX. At temperatures above the TNT melt, the mechanical behavior of Comp B is complex and sensitive to handling conditions (for instance, stirred versus stationary). In this presentation, we will discuss our experiments studying the motion of embedded beads of various densities different from Comp B density as the system is heated above the TNT melt temperature and before the onset of significant gas generation in the Comp B which acts to mix the RDX and molten TNT. X-ray radiography was used to directly observe the motion of the embedded bead in the Comp B as it is slowly and uniformly heated.

Cartilage oligomeric matrix protein-deficient mice have normal skeletal development.

PubMed

Svensson, Liz; Aszódi, Attila; Heinegård, Dick; Hunziker, Ernst B; Reinholt, Finn P; Fässler, Reinhard; Oldberg, Ake

2002-06-01

Cartilage oligomeric matrix protein (COMP) belongs to the thrombospondin family and is a homopentamer primarily expressed in cartilage. Mutations in the COMP gene result in the autosomal dominant chondrodysplasias pseudoachondroplasia (PSACH) and some types of multiple epiphyseal dysplasia (MED), which are characterized by mild to severe short-limb dwarfism and early-onset osteoarthritis. We have generated COMP-null mice to study the role of COMP in vivo. These mice show no anatomical, histological, or ultrastructural abnormalities and show none of the clinical signs of PSACH or MED. Northern blot analysis and immunohistochemical analysis of cartilage indicate that the lack of COMP is not compensated for by any other member of the thrombospondin family. The results also show that the phenotype in PSACH/MED cartilage disorders is not caused by the reduced amount of COMP.

Treatment of complex sleep apnea syndrome: a retrospective comparative review.

PubMed

Pusalavidyasagar, Snigdha S; Olson, Eric J; Gay, Peter C; Morgenthaler, Timothy I

2006-09-01

Some patients with obstructive sleep apnea syndrome (OSAS) develop problematic central apneas or Cheyne-Stokes pattern with acute application of continuous positive airway pressure (CPAP), herein called complex sleep apnea syndrome (CompSAS). This response makes it difficult to be certain that CPAP will be a successful treatment strategy. We sought to compare treatments between patients with CompSAS vs. OSAS and hypothesized that CompSAS patients would find CPAP less effective and have more problems with adherence than patients with OSAS. We performed a retrospective review of patients studied in our sleep disorders center over 1 month. There were 133 patients with OSAS (mean age=57.6+/-12.2 years; males=63.9%) and 34 with CompSAS (mean age=54.4+/-16 years; males=82.35%). CPAP was prescribed in 93.7 and 87.9% of OSAS and CompSAS patients, respectively (P=0.284), with no significant difference in required CPAP pressures (P=0.112). There was no difference in prescription frequency of alternative therapies. Mean time to the first follow-up was shorter in CompSAS patients (46.2+/-47.3 vs. 53.8+/-36.8 days; P=0.022). CPAP compliance in OSAS and CompSAS patients (5.1+/-1.6 vs. 6.1+/-1.5h, P=0.156) and improvement in Epworth Sleepiness Scale (ESS) (-4.6+/-4.8 vs. -5.9+/-6.9, P=0.483) was similar. However, interface problems were more common in CompSAS patients, especially air hunger/dyspnea (0.8 vs. 8.8%) and inadvertent mask removal (2.6 vs. 17.7%) (all P<0.050). CompSAS patients have more CPAP interface problems and require more follow-up than OSAS patients but with intervention may have similar treatment results compared to patients with OSAS.

Continuous positive airway pressure intolerance associated with elevated nasal resistance is possible mechanism of complex sleep apnea syndrome.

PubMed

Nakazaki, Chie; Noda, Akiko; Yasuda, Yoshinari; Nakata, Seiichi; Koike, Yasuo; Yasuma, Fumihiko; Murohara, Toyoaki; Nakashima, Tsutomu

2012-09-01

Complex sleep apnea syndrome (CompSAS) is diagnosed after an elimination of obstructive events with continuous positive airway pressure (CPAP), when a central apnea index ≥5/h or Cheyne-Stokes respiration pattern emerges in patients with obstructive sleep apnea syndrome (OSAS). However, the pathophysiology of CompSAS remains controversial. Of the 281 patients with suspected OSAS, all of whom underwent polysomnography conducted at Nagoya University Hospital, we enrolled 52 patients with apnea-hypopnea index ≥15/h (age 51.4 ± 13.3 years). The polysomnographic findings, left ventricular ejection fraction (LVEF), and nasal resistance were compared between the CompSAS patients and OSAS patients. Forty-three patients were diagnosed with OSAS and nine patients with central sleep apnea syndrome by natural sleep PSG. Furthermore, 43 OSAS patients were classified into the OSAS patients (OSAS group, n = 38) and the CompSAS patients (CompSAS group, n = 5) by the night on CPAP PSG. The nasal resistance was significantly higher in CompSAS group than in OSAS group (0.30 ± 0.10 vs. 0.19 ± 0.07 Pa/cm(3)/s, P = 0.004). The arousal index, percentage of stage 1 sleep, and oxygen desaturation index were significantly decreased, and the percentage of stage REM sleep was significantly increased in the OSAS group with the initial CPAP treatment, but not in the CompSAS group. In addition, the patients with CompSAS showed normal LVEF. CPAP intolerance secondary to an elevated nasal resistance might relate to frequent arousals, which could presumably contribute to an increase in central sleep apnea. Further evaluation in a large study is needed to clarify the mechanism of CompSAS.

Research and Enhancement of Used Tyres, Such as Material Innovative in Algeria

NASA Astrophysics Data System (ADS)

Belabdelouahab, F.; Trouzine, H.

Currently engineers seeking to improve the characteristics of soils used for the construction of earthworks, with innovations developed from ideas, products or processes of original construction, the land army is an early example particularly successful but there are many other processes as well as other Pneusol processes more or less known to sometimes use bulky industrial wastes, while fitting well into the existing environment. In this paper, we discuss a particular research work within the framework of environmental protection and sustainable development, led to the realization of the recovery and reuse of used tires in the construction of works civil engineering. The main objective of this paper is to present the results of studies in Algiers on ENSTP "Pneusol reducing the thrust" on a scale model on the study of a retaining wall reinforced by a simulation tablecloths tires, and the results of particular research enterprise at the University Djillali Liabes of Sidi Bel Abbes, on an experimental campaign on the Pneusol under expansive soil foundations. Topics will also present the projects carried out in Algeria, as the pilot of stability of a slope to Pneusol in Bousmail (2005), then another item of protection against landslides in Bejaia (2006), from the project of Africa in Mostaganem (2007), concerning the stability of an embankment on the RN11 road, and the conduct of a small dike protection technology Pneusol in Blida (2008), and in 2010 the stability of a landslide in Miliana.

30 CFR 941.780 - Surface mining permit applications-minimum requirements for reclamation and operation plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

... demonstrate compliance with the South Dakota laws on air pollution, S. D. Comp. Laws Ann. Chap. 34A-1, water pollution control, S. D. Comp. Laws Ann. Chap. 34A-2, and solid waste disposal, S. D. Comp. Laws Ann. Chap...

High Performance Split-Stirling Cooler Program

DTIC Science & Technology

1982-09-01

or crankcase subassembly includes the two drive cranks 1800 apart, the two motor bearings, the flywheel and target wheel . This assembly is dynamically...DISPLACER SEAL FRICTION REGENERATOR FLOW @ lOPSI E"I’ •’ REGENERATOR RUNOUT COMP. BRG. LUBRICATION "COMP. PISTON SEAL COMP. PISTON SEAL FRICTION INTER

A Framework for Classifying and Resolving Semantic Conflicts Using the Enhanced Entity-Relationship Model

DTIC Science & Technology

1992-09-01

rank, social security number, and date of birth, sex , race, etc. It also keeps data on marital status, number of dependents, and whether a member’s...specification as listed in the appendix. OPINS stores similar common personnel information to that in the ADMI database, such as name, rank, sex , etc.. The...34+ NAME (comp) "+ DATE..OF-.BIRTH (comp) "+ SEX "+ BACE-MIHNIC "+ ETHNIC..GROUP "+ PAYýENTRY-.BASE..DATE (comp) "+ SERVICE "+ MOS (comp) "+ DATE-OF

Multimission Modular Spacecraft Ground Support Software System (MMS/GSSS) state-of-the-art computer systems/ compatibility study

NASA Technical Reports Server (NTRS)

1980-01-01

The compatibility of the Multimission Modular Spacecraft (MMS) Ground Support Software System (GSSS), currently operational on a ModComp IV/35, with the VAX 11/780 system is discussed. The compatibility is examined in various key areas of the GSSS through the results of in depth testing performed on the VAX 11/780 and ModComp IV/35 systems. The compatibility of the GSSS with the ModComp CLASSIC is presented based upon projections from ModComp supplied literature.

Disentangling Dominance: Obscured AGN Activity versus Star Formation in BPT-Composites

NASA Astrophysics Data System (ADS)

Trouille, Laura

2011-11-01

Approximately 20% of SDSS emission-line galaxies (ELG) lie in the BPT-comp regime, between the Kauffmann et al. (2003) empirically determined SF-dominated regime and the Kewley et al. (2001) theoretically predicted AGN-dominated regime. BPT-AGN, on the other hand, make up only 11% of the ELG population. Whether to include the significant number of BPT-comp in samples of AGN or samples of star-forming galaxies is an open question and has important implications for galaxy evolution studies, metallicity studies, etc. Using a large pectroscopic sample of GOODS-N and LH galaxies with deep Chandra imaging, we perform an X-ray stacking analysis of BPT-comp. We find the stacked signal to be X-ray hard. This X-ray hardness can be indicative of obscured AGN activity or the presence of HMXBs associated with ongoing star formation. In order to distinguish between these scenarios, we perform an IR stacking analysis using Spitzer 24 micron data. The stacked BPT-comp lies well above the expected value for L_x/L_IR for pure star-forming galaxies; similarly for the X-ray detected BPT-comp. We also find that the BPT-comp lie in the AGN-dominated regime of our new TBT diagnostic, which uses [NeIII]/[OII] versus rest-frame g-z colour to identify AGN and star forming galaxies out to z=1.4. [NeIII], which has a higher ionisation potential than other commonly used forbidden emission lines, appears to foster a more reliable selection of AGN-dominated galaxies. These findings suggest that both the X-ray and optical signal in BPT-comp are dominated by obscured or low accretion rate AGN activity rather than star formation. This is in contrast to claims by previous optical emission-line studies that the signal in BPT-comp is dominated by star-formation activity. Therefore, we recommend that groups carefully consider the impact of excluding or including BPT-comp on the interpretation of their results. For example, for studies involving determining the bolometric contribution from AGN activity or the role of AGN activity in galaxy evolution, we advise maximal inclusiveness. Since BPT-comp comprise a significant percentage of the overall emission-line galaxy population, inclusion of the BPT-comp would provide a more comprehensive picture of the true impact of AGN activity in these studies.

A novel endpoint for exacerbations in asthma to accelerate clinical development: a post-hoc analysis of randomised controlled trials.

PubMed

Fuhlbrigge, Anne L; Bengtsson, Thomas; Peterson, Stefan; Jauhiainen, Alexandra; Eriksson, Göran; Da Silva, Carla A; Johnson, Anthony; Sethi, Tariq; Locantore, Nicholas; Tal-Singer, Ruth; Fagerås, Malin

2017-07-01

Occurrence of severe asthma exacerbations are the cornerstone of the evaluation of asthma management, but severe asthma exacerbations are rare events. Therefore, trials that assess drug efficacy on exacerbations are done late in clinical development programmes. We aimed to establish an endpoint capturing clinically relevant deteriorations (diary events) that, when combined with severe exacerbations, create a composite outcome (CompEx). CompEx needs to strongly mirror results seen with the severe exacerbation-validated outcome, to allow the design of clinical trials of shorter duration and that include fewer patients than trials assessing severe exacerbations. Data from 12 asthma trials of 6 months or 12 months duration and, with standardised collection of exacerbations and diary card variables, were used to construct and test CompEx. The study populations had a mean age of 35-53 years, 59-69% were female, and had a mean FEV 1 percentage of predicted normal of 63-84%. With data from five trials, we established a series of diary events based on peak expiratory flow (P), reliever use (R), symptoms (S), awakenings (A), and threshold values for change from baseline and slopes to assess trends. For the development phase, we evaluated different variable combinations and deterioration criteria to select the most robust algorithm to define a diary event for the composite outcome. We defined a composite outcome, CompEx, as first occurrence of a diary event or a severe exacerbation. We assessed the performance of CompEx in seven trials by comparing the event frequency, treatment effect (hazard ratio; HR), and the sample size needed for future trials for the CompEx versus episodes of severe exacerbations. CompEx (based on PRS) was the algorithm that best fulfilled our two-set criteria. When censored at 3 months, CompEx resulted in 2·8 times more events than severe exacerbations, and while preserving the treatment effect observed on severe exacerbations (CompEx over severe exacerbation average HR 1·01). The increased number of events, together with the sustained treatment effect, resulted in a large net gain in power, with a 67% mean reduction in the number of patients required in a drug trial for severe exacerbations. In six of seven comparisons tested, CompEx reduced the sample size needed by at least 50%. Validation of independent test populations confirmed the ability of CompEx to increase event frequencies, preserve treatment effect, and reduce the number of patients needed. CompEx is a composite outcome for evaluation of new asthma therapies. CompEx allows design of shorter trials that require fewer patients than studies of severe exacerbations, while preserving the ability to show a treatment effect compared with severe exacerbations. AstraZeneca. Copyright © 2017 Elsevier Ltd. All rights reserved.

A learnable parallel processing architecture towards unity of memory and computing.

PubMed

Li, H; Gao, B; Chen, Z; Zhao, Y; Huang, P; Ye, H; Liu, L; Liu, X; Kang, J

2015-08-14

Developing energy-efficient parallel information processing systems beyond von Neumann architecture is a long-standing goal of modern information technologies. The widely used von Neumann computer architecture separates memory and computing units, which leads to energy-hungry data movement when computers work. In order to meet the need of efficient information processing for the data-driven applications such as big data and Internet of Things, an energy-efficient processing architecture beyond von Neumann is critical for the information society. Here we show a non-von Neumann architecture built of resistive switching (RS) devices named "iMemComp", where memory and logic are unified with single-type devices. Leveraging nonvolatile nature and structural parallelism of crossbar RS arrays, we have equipped "iMemComp" with capabilities of computing in parallel and learning user-defined logic functions for large-scale information processing tasks. Such architecture eliminates the energy-hungry data movement in von Neumann computers. Compared with contemporary silicon technology, adder circuits based on "iMemComp" can improve the speed by 76.8% and the power dissipation by 60.3%, together with a 700 times aggressive reduction in the circuit area.

The CompHP Core Competencies Framework for Health Promotion in Europe

ERIC Educational Resources Information Center

Barry, Margaret M.; Battel-Kirk, Barbara; Dempsey, Colette

2012-01-01

Background: The CompHP Project on Developing Competencies and Professional Standards for Health Promotion in Europe was developed in response to the need for new and changing health promotion competencies to address health challenges. This article presents the process of developing the CompHP Core Competencies Framework for Health Promotion across…

The EPA CompTox Chemistry Dashboard - an online resource for environmental chemists (ACS Spring Meeting)

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) Computational Toxicology Program integrates advances in biology, chemistry, and computer science to help prioritize chemicals for further research based on potential human health risks. This work involves computational and data drive...

Strategic Pay Reform: A Student Outcomes-Based Evaluation of Denver's ProComp Teacher Pay Initiative

ERIC Educational Resources Information Center

Goldhaber, Dan; Walch, Joe

2012-01-01

Denver Public Schools utilizes one of the nation's highest profile alternative teacher compensation systems, and a key element of Denver's Professional Compensation System for Teachers (ProComp) is pay for performance. This study analyzes the student achievement implications of ProComp utilizing matched student- and teacher-level data from 2003 to…

The distribution patterns of COMP and matrilin-3 in septal, alar and triangular cartilages of the human nose.

PubMed

Wiggenhauser, Paul Severin; Schwarz, Silke; Rotter, Nicole

2018-05-02

The biomechanical characteristics of septal cartilage depend strongly on the distinct extracellular matrix of cartilage tissue; therefore, it is essential that the components of this matrix are identified and understood. Cartilage oligomeric matrix protein (COMP) and matrilin-3 are localised in articular cartilage. This study was the first to examine all subtypes of mature human nasal cartilages (alar, triangular and septal) with specific attention to the distribution of COMP and matrilin-3. Three whole fresh-frozen noses from human donors were dissected, and exemplary biopsies were examined using histochemical staining (haematoxylin and eosin and Alcian blue) and immunohistochemistry (collagen II, COMP and matrilin-3). The following three zones within the nasal cartilage were identified: superficial, intermediate and central. COMP was detected as highest in the intermediate zones in all three subtypes of nasal cartilage, whereas matrilin-3 was detected with pericellular deposition mainly within septal cartilage predominantly in the superficial zones. The distinct staining patterns of COMP and matrilin-3 underscore the different functional roles of both proteins in nasal cartilage. According to the literature, COMP might be involved with collagen II in the formation of networks, whereas matrilin-3 is reported to prevent ossification or regulate mechanosensitivity. The predominant staining observed in septal cartilage suggests matrilin-3's modulatory role because of its presence in the osteochondral junctional zone and given that the biomechanical load in septal cartilage is different from that in alar or triangular cartilage. In conclusion, COMP and matrilin-3 were detected in mature human nasal cartilage but displayed different staining patterns that might be explained by the functional roles of the respective matrix protein; however, further research is necessary to identify and define the functional aspects of this morphological difference.

Syntax-Prosody Interface: Evidence from wh-Movement in Jordanian Arabic and Egyptian Arabic

ERIC Educational Resources Information Center

Yasin, Ayman

2012-01-01

Richards (2006, 2010) suggests that wh-movement is prosodically driven. Based on the position of the Comp(lementizer) and the marking of prosodic phrase edges, he claims that if Comp is on one side and the language marks the opposite side of prosodic phrases, then the wh-phrase does not move since Comp and wh-phrase can create a prosodic wh-domain…

Competitor presence reduces internal attentional focus and improves 16.1km cycling time trial performance.

PubMed

Williams, Emily L; Jones, Hollie S; Andy Sparks, S; Marchant, David C; Midgley, Adrian W; Mc Naughton, Lars R

2015-07-01

Whilst the presence of a competitor has been found to improve performance, the mechanisms influencing the change in selected work rates during direct competition have been suggested but not specifically assessed. The aim was to investigate the physiological and psychological influences of a visual avatar competitor during a 16.1-km cycling time trial performance, using trained, competitive cyclists. Randomised cross-over design. Fifteen male cyclists completed four 16.1km cycling time trials on a cycle ergometer, performing two with a visual display of themselves as a simulated avatar (FAM and SELF), one with no visual display (DO), and one with themselves and an opponent as simulated avatars (COMP). Participants were informed the competitive avatar was a similar ability cyclist but it was actually a representation of their fastest previous performance. Increased performance times were evident during COMP (27.8±2.0min) compared to SELF (28.7±1.9min) and DO (28.4±2.3min). Greater power output, speed and heart rate were apparent during COMP trial than SELF (p<0.05) and DO (p≤0.06). There were no differences between SELF and DO. Ratings of perceived exertion were unchanged across all conditions. Internal attentional focus was significantly reduced during COMP trial (p<0.05), suggesting reduced focused on internal sensations during an increase in performance. Competitive cyclists performed significantly faster during a 16.1-km competitive trial than when performing maximally, without a competitor. The improvement in performance was elicited due to a greater external distraction, deterring perceived exertion. Copyright © 2014 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

Identifying known unknowns using the US EPA's CompTox Chemistry Dashboard.

PubMed

McEachran, Andrew D; Sobus, Jon R; Williams, Antony J

2017-03-01

Chemical features observed using high-resolution mass spectrometry can be tentatively identified using online chemical reference databases by searching molecular formulae and monoisotopic masses and then rank-ordering of the hits using appropriate relevance criteria. The most likely candidate "known unknowns," which are those chemicals unknown to an investigator but contained within a reference database or literature source, rise to the top of a chemical list when rank-ordered by the number of associated data sources. The U.S. EPA's CompTox Chemistry Dashboard is a curated and freely available resource for chemistry and computational toxicology research, containing more than 720,000 chemicals of relevance to environmental health science. In this research, the performance of the Dashboard for identifying known unknowns was evaluated against that of the online ChemSpider database, one of the primary resources used by mass spectrometrists, using multiple previously studied datasets reported in the peer-reviewed literature totaling 162 chemicals. These chemicals were examined using both applications via molecular formula and monoisotopic mass searches followed by rank-ordering of candidate compounds by associated references or data sources. A greater percentage of chemicals ranked in the top position when using the Dashboard, indicating an advantage of this application over ChemSpider for identifying known unknowns using data source ranking. Additional approaches are being developed for inclusion into a non-targeted analysis workflow as part of the CompTox Chemistry Dashboard. This work shows the potential for use of the Dashboard in exposure assessment and risk decision-making through significant improvements in non-targeted chemical identification. Graphical abstract Identifying known unknowns in the US EPA's CompTox Chemistry Dashboard from molecular formula and monoisotopic mass inputs.

Annual Progress Report Fiscal Year 1982.

DTIC Science & Technology

1982-09-30

255 Work Jnit No. 82/43 (FY82,O) A\\dolescent Immunity to Varicella and Cytomegalovirus .............. 256 Work Unit No. 82/45 (FY82,O) V!1-26 In...with technetium-99m bone agent(Infarct avid) radiopharmaceuticals. Presented at the New Mexico Society of Internal Medicine, Albuquerque NM, 11-12 Dec...No: 82/43 Status: Ongoing Title: Adolescent Immunity to Varicella and Cytomegalovirus Start Date: Est Comp Date: Principal Investigator: Facility: LTC

Carbon Fiber Composites

NASA Technical Reports Server (NTRS)

1997-01-01

HyComp(R), Inc. development a line of high temperature carbon fiber composite products to solve wear problems in the harsh environment of steel and aluminum mills. WearComp(R), self-lubricating composite wear liners and bushings, combines carbon graphite fibers with a polyimide binder. The binder, in conjunction with the fibers, provides the slippery surface, one that demands no lubrication, yet wears at a very slow rate. WearComp(R) typically lasts six to ten times longer than aluminum bronze. Unlike bronze, WearComp polishes the same surface and imparts a self-lube film for years of service. It is designed for continuous operation at temperatures of 550 degrees Fahrenheit and can operate under high compressive loads.

CompGO: an R package for comparing and visualizing Gene Ontology enrichment differences between DNA binding experiments.

PubMed

Waardenberg, Ashley J; Basset, Samuel D; Bouveret, Romaric; Harvey, Richard P

2015-09-02

Gene ontology (GO) enrichment is commonly used for inferring biological meaning from systems biology experiments. However, determining differential GO and pathway enrichment between DNA-binding experiments or using the GO structure to classify experiments has received little attention. Herein, we present a bioinformatics tool, CompGO, for identifying Differentially Enriched Gene Ontologies, called DiEGOs, and pathways, through the use of a z-score derivation of log odds ratios, and visualizing these differences at GO and pathway level. Through public experimental data focused on the cardiac transcription factor NKX2-5, we illustrate the problems associated with comparing GO enrichments between experiments using a simple overlap approach. We have developed an R/Bioconductor package, CompGO, which implements a new statistic normally used in epidemiological studies for performing comparative GO analyses and visualizing comparisons from . BED data containing genomic coordinates as well as gene lists as inputs. We justify the statistic through inclusion of experimental data and compare to the commonly used overlap method. CompGO is freely available as a R/Bioconductor package enabling easy integration into existing pipelines and is available at: http://www.bioconductor.org/packages/release/bioc/html/CompGO.html packages/release/bioc/html/CompGO.html.

Antioxidant and anti-inflammatory agents mitigate pathology in a mouse model of pseudoachondroplasia

PubMed Central

Posey, Karen L.; Coustry, Francoise; Veerisetty, Alka C.; Hossain, Mohammad; Alcorn, Joseph L.; Hecht, Jacqueline T.

2015-01-01

Pseudoachondroplasia (PSACH), a severe short-limb dwarfing condition, results from mutations that cause misfolding of the cartilage oligomeric matrix protein (COMP). Accumulated COMP in growth plate chondrocytes activates endoplasmic reticulum stress, leading to inflammation and chondrocyte death. Using a MT-COMP mouse model of PSACH that recapitulates the molecular and clinical PSACH phenotype, we previously reported that oxidative stress and inflammation play important and unappreciated roles in PSACH pathology. In this study, we assessed the ability of antioxidant and anti-inflammatory agents to affect skeletal and cellular pathology in our mouse model of PSACH. Treatment of MT-COMP mice with aspirin or resveratrol from birth to P28 decreased mutant COMP intracellular retention and chondrocyte cell death, and restored chondrocyte proliferation. Inflammatory markers associated with cartilage degradation and eosinophils were present in the joints of untreated juvenile MT-COMP mice, but were undetectable in treated mice. Most importantly, these treatments resulted in significantly increased femur length. This is the first and only therapeutic approach shown to mitigate both the chondrocyte and long-bone pathology of PSACH in a mouse model and suggests that reducing inflammation and oxidative stress early in the disease process may be a novel approach to treat this disorder. PMID:25859006

Novel types of COMP mutations and genotype-phenotype association in pseudoachondroplasia and multiple epiphyseal dysplasia.

PubMed

Mabuchi, Akihiko; Manabe, Noriyo; Haga, Nobuhiko; Kitoh, Hiroshi; Ikeda, Toshiyuki; Kawaji, Hiroyuki; Tamai, Kazuya; Hamada, Junichiro; Nakamura, Shigeru; Brunetti-Pierri, Nicola; Kimizuka, Mamori; Takatori, Yoshio; Nakamura, Kozo; Nishimura, Gen; Ohashi, Hirofumi; Ikegawa, Shiro

2003-01-01

Mutations in the gene encoding cartilage oligomeric matrix protein ( COMP) cause two skeletal dysplasias, pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). More than 40 mutations have been identified; however, genotype-phenotype relationships are not well delineated. Further, mutations other than in-frame insertion/deletions and substitutions have not been found, and currently known mutations are clustered within relatively small regions. Here we report the identification of nine novel and three recurrent COMP mutations in PSACH and MED patients. These include two novel types of mutations; the first, a gross deletion spanning an exon-intron junction, causes an exon deletion. The second, a frameshift mutation that results in a truncation of the C-terminal domain, is the first known truncating mutation in the COMP gene. The remaining mutations, other than a novel exon 18 mutation, affected highly conserved aspartate or cysteine residues in the calmodulin-like repeat (CLR) region. Genotype-phenotype analysis revealed a correlation between the position and type of mutations and the severity of short stature. Mutations in the seventh CLR produced more severe short stature compared with mutations elsewhere in the CLRs ( P=0.0003) and elsewhere in the COMP gene ( P=0.0007). Patients carrying mutations within the five-aspartates repeat (aa 469-473) in the seventh CLR were extremely short (below -6 SD). Patients with deletion mutations were significantly shorter than those with substitution mutations ( P=0.0024). These findings expand the mutation spectrum of the COMP gene and highlight genotype-phenotype relationships, facilitating improved genetic diagnosis and analysis of COMP function in humans.

Correlation of serum cartilage oligomeric matrix protein (COMP) and interleukin-16 (IL-16) levels with disease severity in primary knee osteoarthritis: A pilot study in a Malaysian population.

PubMed

Das Gupta, Esha; Ng, Wei Ren; Wong, Shew Fung; Bhurhanudeen, Abdul Kareem; Yeap, Swan Sim

2017-01-01

The aim of this study was to investigate the correlations between serum cartilage oligomeric matrix protein (COMP), interleukin-16 (IL-16) and different grades of knee osteoarthritis (KOA) in Malaysian subjects. Ninety subjects were recruited comprising 30 with Kellgren-Lawrence (K-L) grade 2 KOA, 27 with K-L grade 3 KOA, 7 with grade 4 KOA, and 30 healthy controls. All subjects completed the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire. Serum COMP and IL-16 levels were measured using ELISA and their values log transformed to ensure a normal distribution. There was no significant differences in levels of log serum COMP and IL-16 between healthy controls and KOA patients. There were no significant differences in the log serum COMP and IL-16 levels within the different K-L grades in the KOA patients. In KOA patients, log serum IL-16 levels significantly correlated with the WOMAC score (p = 0.001) and its subscales, pain (p = 0.005), stiffness (p = 0.019) and physical function (p<0.0001). Serum IL-16 levels were significantly higher in Malaysian Indians compared to Malays and Chinese (p = 0.024). In this multi-ethnic Malaysian population, there was no difference in serum COMP and IL-16 levels between healthy controls and patients with KOA, nor was there any difference in serum COMP or IL-16 levels across the various K-L grades of KOA. However, there were significant inter-racial differences in serum IL-16 levels.

Low serum level of COMP, a cartilage turnover marker, predicts rapid and high ACR70 response to adalimumab therapy in rheumatoid arthritis.

PubMed

Morozzi, G; Fabbroni, M; Bellisai, F; Cucini, S; Simpatico, A; Galeazzi, M

2007-08-01

The aim of this study was to evaluate serum biomarkers, used in clinical routine, to predict the American College of Rheumatology (ACR) response to long-term anti-TNF alpha treatment (adalimumab). Sera from 29 consecutive rheumatoid arthritis patients were analysed for anti-cyclic citrullinated peptide (anti-CCP), cartilage oligomeric matrix protein (COMP) and IgM and IgA RFs (class-specific rheumatoid factors) at the start of treatment with adalimumab and after 3, 6 and 12 months. The response to the therapy was evaluated by ACR 20, 50, 70 and by DAS 28 scores. The mean serum COMP level of the population did not change after treatment. However, patients with low serum COMP levels (<10 U/l) at baseline showed a significant (p<0.02) higher ACR70 response (>50%) within 3 months, and also at 6 months, than patients with higher COMP values (ACR70<20%). This was also reflected by significantly higher decrease in DAS score at 3 (p<0.02) and 6 months (p<0.01) treatments. The IgM RF titre decreased significantly (p=0.02) after the therapy, but the percentage of serum positivity for anti-CCP and IgA/IgM RF did not change. No significant correlation was shown between serum COMP levels and C-reactive protein/erythrocyte sedimentation rate during the follow-up. Neither were any correlations shown between ACR/DAS 28 scores and anti-CCP, Ig M/IgA RFs. Our data indicate that low (<10 U/l) serum COMP before starting anti-TNF alpha treatment predicts a rapid (within 3 months) and high ACR70 response compared to RA patients with higher COMP values. This might reflect different mechanisms in the cartilage process in the RA disease at that time of treatment with different therapeutic sensitivity to anti-TNF alpha treatment.

The efficacy of prospective memory rehabilitation plus metacognitive skills training for adults with traumatic brain injury: study protocol for a randomized controlled trial.

PubMed

Fleming, Jennifer; Ownsworth, Tamara; Doig, Emmah; Hutton, Lauren; Griffin, Janelle; Kendall, Melissa; Shum, David H K

2017-01-05

Impairment of prospective memory (PM) is common following traumatic brain injury (TBI) and negatively impacts on independent living. Compensatory approaches to PM rehabilitation have been found to minimize the impact of PM impairment in adults with TBI; however, poor self-awareness after TBI poses a major barrier to the generalization of compensatory strategies in daily life. Metacognitive skills training (MST) is a cognitive rehabilitation approach that aims to facilitate the development of self-awareness in adults with TBI. This paper describes the protocol of a study that aims to evaluate the efficacy of a MST approach to compensatory PM rehabilitation for improving everyday PM performance and psychosocial outcomes after TBI. This randomized controlled trial has three treatment groups: compensatory training plus metacognitive skills training (COMP-MST), compensatory training only (COMP), and waitlist control. Participants in the COMP-MST and COMP groups will complete a 6-week intervention consisting of six 2-h weekly training sessions. Each 1.5-h session will involve compensatory strategy training and 0.5 h will incorporate either MST (COMP-MST group) or filler activity as an active control (COMP group). Participants in the waitlist group receive care as usual for 6 weeks, followed by the COMP-MST intervention. Based on the sample size estimate, 90 participants with moderate to severe TBI will be randomized into the three groups using a stratified sampling approach. The primary outcomes include measures of PM performance in everyday life and level of psychosocial reintegration. Secondary outcomes include measures of PM function on psychometric testing, strategy use, self-awareness, and level of support needs following TBI. Blinded assessments will be conducted pre and post intervention, and at 3-month and 6-month follow-ups. This study seeks to determine the efficacy of COMP-MST for improving and maintaining everyday PM performance and level of psychosocial integration in adults with moderate to severe TBI. The findings will advance theoretical understanding of the role of self-awareness in compensatory PM rehabilitation and skills generalization. COMP-MST has the potential to reduce the cost of rehabilitation and lifestyle support following TBI because the intervention could enhance generalization success and lifelong application of PM compensatory strategies. New Zealand Clinical Trials Registry, ACTRN12615000996561 . Registered on 23 September 2015; retrospectively registered 2 months after commencement.

High Efficiency Heat Exchanger for High Temperature and High Pressure Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sienicki, James J.; Lv, Qiuping; Moisseytsev, Anton

CompRex, LLC (CompRex) specializes in the design and manufacture of compact heat exchangers and heat exchange reactors for high temperature and high pressure applications. CompRex’s proprietary compact technology not only increases heat exchange efficiency by at least 25 % but also reduces footprint by at least a factor of ten compared to traditional shell-and-tube solutions of the same capacity and by 15 to 20 % compared to other currently available Printed Circuit Heat Exchanger (PCHE) solutions. As a result, CompRex’s solution is especially suitable for Brayton cycle supercritical carbon dioxide (sCO2) systems given its high efficiency and significantly lower capitalmore » and operating expenses. CompRex has already successfully demonstrated its technology and ability to deliver with a pilot-scale compact heat exchanger that was under contract by the Naval Nuclear Laboratory for sCO2 power cycle development. The performance tested unit met or exceeded the thermal and hydraulic specifications with measured heat transfer between 95 to 98 % of maximum heat transfer and temperature and pressure drop values all consistent with the modeled values. CompRex’s vision is to commercialize its compact technology and become the leading provider for compact heat exchangers and heat exchange reactors for various applications including Brayton cycle sCO2 systems. One of the limitations of the sCO2 Brayton power cycle is the design and manufacturing of efficient heat exchangers at extreme operating conditions. Current diffusion-bonded heat exchangers have limitations on the channel size through which the fluid travels, resulting in excessive solid material per heat exchanger volume. CompRex’s design allows for more open area and shorter fluid proximity for increased heat transfer efficiency while sustaining the structural integrity needed for the application. CompRex is developing a novel improvement to its current heat exchanger design where fluids are directed to alternating channels so that each fluid is fully surrounded by the opposing fluid. As compared to similar existing compact heat exchangers, the new design converts most secondary surface area to primary surface area, eliminating fin inefficiencies. CompRex requests that all technical information about the heat exchanger designs be protected as proprietary information. To honor that request, only non-proprietay summaries are included in this report.« less

Les caractéristiques de la collaboration mère-enfant à 48 mois dans deux tâches de numération

PubMed Central

Caron, Lisbeth; Parent, Sophie; Normandeau, Sylvie; Tremblay, Richard E.; Séguin, Jean R.

2017-01-01

RÉSUMÉ Afin d’étudier les connaissances relatives au développement de la numération à l’âge préscolaire, cette recherche examine les manifestations de ces compétences dans un contexte de collaboration mère-enfant. La collaboration entre les mères et leur enfant de 4 ans (n = 193) est observée et analysée dans le contexte de deux tâches de numération. Les résultats complètent les études antérieures sur les compétences maîtrisées par les enfants d’âge préscolaire en performance individuelle en identifiant les compétences en cours d’acquisition exercées avec le soutien de la mère. Les résultats montrent ainsi que les mères ajustent les exigences de la tâche aux compétences de leur enfant afin d’étayer l’exercice de leurs compétences : elles modèlent les compétences numéraires nouvelles et elles soutiennent l’exercice par l’enfant des compétences maîtrisées ou en voie de l’être. Les résultats indiquent également qu’au-delà de l’encadrement de la participation et du transfert progressif des responsabilités cognitives à l’enfant, l’étayage maternel en contexte de numération favorise aussi le soutien de la motivation de l’enfant et le maintien d’un climat affectif harmonieux. PMID:28566773

Visual Information Theory and Visual Representation for Achieving Provable Bounds in Vision-Based Control and Decision

DTIC Science & Technology

2014-07-30

of the IEEE Intl. Conf. on Comp. Vis. and Patt . Recog. (CVPR). 07-JAN-14, . : , B. Taylor, A. Ayvaci, A. Ravichandran, and S. Soatto.. Semantic video...detection, localization and tracking, Intl. Conf. on Comp. Vis. Patt . Recog.. 06-JAN-11, . : , Michalis Raptis, Iasonas Kokkinos, Stefano Soatto...of the IEEE Intl. Conf. on Comp. Vis. and Patt . Recog., 2012. [12] M. Raptis and S. Soatto. Tracklet descriptors for action modeling and video

Reliability Programs for Nonelectronic Designs. Volume 1

DTIC Science & Technology

1983-04-01

to the system or component levels or to both and then Its degree of effectiveness. DOCUMENT ID TITLE/SUBJECT APPLICATION EFFECTIVENESS Sys ./Comp/Both...ID TITLE/SUBJECT APPLICATION EFFECTIVENESS ’ Sys ./Comp/Both Exc./Good/Poor MIL-STD-781B Reliability Tests Exponen- 1 1 1 1 Ii II tial Distribution MIL...DOCUMENT ID TITLE/SUBJECT APPLICATION EFFECTIVENESS Sys ./Comp/Both Exc./Good/Poor MIL-STD-1535A Supplier Quality Assurance I 1 I1 I 1 1 I Program

Cryomilled zinc sulfide: A prophylactic for Staphylococcus aureus-infected wounds

DOE PAGES

Tran, Phat L.; Li, Jianqiang; Lungaro, Lisa; ...

2018-04-23

Bacterial pathogens that colonize wounds form biofilms, which protect the bacteria from the effect of host immune response and antibiotics. This paper examined the effectiveness of newly synthesized zinc sulfide in inhibiting biofilm development by Staphylococcus aureus (S. aureus) strains. Zinc sulfide (ZnS) was anaerobically biosynthesized to produce CompA, which was further processed by cryomilling to maximize the antibacterial properties to produce CompB. The effect of the two compounds on the S. aureus strain AH133 was compared using zone of inhibition assay. The compounds were formulated in a polyethylene glycol cream. We compared the effect of the two compounds onmore » biofilm development by AH133 and two methicillin-resistant S. aureus clinical isolates using the in vitro model of wound infection. Zone of inhibition assay revealed that CompB is more effective than CompA. At 15 mg/application, the formulated cream of either compound inhibited biofilm development by AH133, which was confirmed using confocal laser scanning microscopy. At 20 mg/application, CompB inhibited biofilm development by the two methicillin-resistant S. aureus clinical isolates. To further validate the effectiveness of CompB, mice were treated using the murine model of wound infection. Finally, colony forming cell assay and in vivo live imaging results strongly suggested the inhibition of S. aureus growth.« less

Cryomilled zinc sulfide: A prophylactic for Staphylococcus aureus-infected wounds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tran, Phat L.; Li, Jianqiang; Lungaro, Lisa

Bacterial pathogens that colonize wounds form biofilms, which protect the bacteria from the effect of host immune response and antibiotics. This paper examined the effectiveness of newly synthesized zinc sulfide in inhibiting biofilm development by Staphylococcus aureus (S. aureus) strains. Zinc sulfide (ZnS) was anaerobically biosynthesized to produce CompA, which was further processed by cryomilling to maximize the antibacterial properties to produce CompB. The effect of the two compounds on the S. aureus strain AH133 was compared using zone of inhibition assay. The compounds were formulated in a polyethylene glycol cream. We compared the effect of the two compounds onmore » biofilm development by AH133 and two methicillin-resistant S. aureus clinical isolates using the in vitro model of wound infection. Zone of inhibition assay revealed that CompB is more effective than CompA. At 15 mg/application, the formulated cream of either compound inhibited biofilm development by AH133, which was confirmed using confocal laser scanning microscopy. At 20 mg/application, CompB inhibited biofilm development by the two methicillin-resistant S. aureus clinical isolates. To further validate the effectiveness of CompB, mice were treated using the murine model of wound infection. Finally, colony forming cell assay and in vivo live imaging results strongly suggested the inhibition of S. aureus growth.« less

Improvement of reduced serum cartilage oligomeric matrix protein levels in systemic juvenile idiopathic arthritis patients treated with the anti-interleukin-6 receptor monoclonal antibody tocilizumab.

PubMed

Nakajima, Shoko; Naruto, Takuya; Miyamae, Takako; Imagawa, Tomoyuki; Mori, Masaaki; Nishimaki, Shigeru; Yokota, Shumpei

2009-01-01

In this study, we determined serum cartilage oligomeric matrix protein (COMP) levels in systemic juvenile idiopathic arthritis (sJIA) patients during both the active and the remission phases to investigate how the growth cartilage turnover changed under tocilizumab treatment. Specimens were collected from 201 healthy children under 16 years of age with no growth impairment, and paired sera were collected from 11 sJIA patients treated with tocilizumab. Disease activity was assessed from white blood cell count, erythrocyte sedimentation rate, C-reactive protein, and ferritin, and the COMP concentration was determined by sandwich enzyme-linked immunosorbent assay. Serum COMP concentrations were found independent of age, and the mean value in healthy children was 17.74+/-5.6 U/L. The mean serum COMP in sJIA patients during the active phase was 10.75+/-3.9 U/L, lower than that of healthy children. The mean serum COMP in the remission phase (14.89+/-3.9 U/L) was significantly higher than that in the active period (P<0.05). These results suggested that in sJIA patients, a reduced serum COMP concentration is a useful marker of active disease and growth impairment, and that the growth cartilage turnover suppressed during the active phase is improved in the remission phase under tocilizumab treatment.

[Clinical features and COMP gene mutation in a family with a pseudoachondroplasia child].

PubMed

Lu, Chun-Ting; Guo, Li; Zahng, Zhan-Hui; Lin, Wei-Xia; Song, Yuan-Zong; Feng, Lie

2013-11-01

This study aimed to report the clinical characteristics and COMP gene mutation of a family with pseudoachondroplasia (PSACH), a relatively rare spinal and epiphyseal dysplasia that is inherited as an autosomal dominant trait. Clinical information on a 5-year-2-month-old PSACH child and his parents was collected and analyzed. Diagnosis was confirmed by PCR amplification and direct sequencing of all the 19 exons and their flanking sequences of COMP gene, and the mutation was further ascertained by cloning analysis of exon 10. The child presented with short and stubby fingers, bow leg, short limb dwarfism and metaphysic broadening in long bone as well as lumbar lordosis. A mutation c.1048_1116del (p.Asn350_Asp372del) in exon 10, inherited from his father who did not demonstrate any phenotypic feature of PSACH, was detected in the child. PSACH was diagnosed definitively by means of COMP mutation analysis, on the basis of the child's clinical and imaging features. The non-penetrance phenomenon of COMP mutation was described for the first time in PSACH.

Parallel filtering in global gyrokinetic simulations

NASA Astrophysics Data System (ADS)

Jolliet, S.; McMillan, B. F.; Villard, L.; Vernay, T.; Angelino, P.; Tran, T. M.; Brunner, S.; Bottino, A.; Idomura, Y.

2012-02-01

In this work, a Fourier solver [B.F. McMillan, S. Jolliet, A. Bottino, P. Angelino, T.M. Tran, L. Villard, Comp. Phys. Commun. 181 (2010) 715] is implemented in the global Eulerian gyrokinetic code GT5D [Y. Idomura, H. Urano, N. Aiba, S. Tokuda, Nucl. Fusion 49 (2009) 065029] and in the global Particle-In-Cell code ORB5 [S. Jolliet, A. Bottino, P. Angelino, R. Hatzky, T.M. Tran, B.F. McMillan, O. Sauter, K. Appert, Y. Idomura, L. Villard, Comp. Phys. Commun. 177 (2007) 409] in order to reduce the memory of the matrix associated with the field equation. This scheme is verified with linear and nonlinear simulations of turbulence. It is demonstrated that the straight-field-line angle is the coordinate that optimizes the Fourier solver, that both linear and nonlinear turbulent states are unaffected by the parallel filtering, and that the k∥ spectrum is independent of plasma size at fixed normalized poloidal wave number.

Multi-particle phase space integration with arbitrary set of singularities in CompHEP

NASA Astrophysics Data System (ADS)

Kovalenko, D. N.; Pukhov, A. E.

1997-02-01

We describe an algorithm of multi-particle phase space integration for collision and decay processes realized in CompHEP package version 3.2. In the framework of this algorithm it is possible to regularize an arbitrary set of singularities caused by virtual particle propagators. The algorithm is based on the method of the recursive representation of kinematics and on the multichannel Monte Carlo approach. CompHEP package is available by WWW: http://theory.npi.msu.su/pukhov/comphep.html

CompHEP: developments and applications

NASA Astrophysics Data System (ADS)

Boos, E. E.; Bunichev, V. E.; Dubinin, M. N.; Ilyin, V. A.; Savrin, V. I.; CompHEP Collaboration

2017-11-01

New developments of the CompHEP package and its applications to the top quark and the Higgs boson physics at the LHC collider are reviewed. These developments were motivated mainly by the needs of experimental searches of DO (Tevatron) and CMS (LHC) collaborations where identification of the top quark and the Higgs boson in the framework of the Standard Model (SM) or possible extensions of the SM played an important role. New useful features of the CompHEP Graphics User Interface (GUI) are described.

Continuation of research into language concepts for the mission support environment

NASA Technical Reports Server (NTRS)

1991-01-01

A concept for a more intuitive and graphically based Computation (Comp) Builder was developed. The Graphical Comp Builder Prototype was developed, which is an X Window based graphical tool that allows the user to build Comps using graphical symbols. Investigation was conducted to determine the availability and suitability of the Ada programming language for the development of future control center type software. The Space Station Freedom Project identified Ada as the desirable programming language for the development of Space Station Control Center software systems.

Domestic Preference Policies in Federal Procurement

DTIC Science & Technology

1990-01-01

prohibiting awards of certain service contracts,33 it does not purport to require such considerations with respect to the award of tm See, e.g., Lenzar ...of another specific exception to the Act4 3 or other statutory provision, for limiting 3 0See, e.g., Lenzar Optics Corp., Comp. Gen. Dec. B-225432...country source). eleSee, e.g., Lenzar Optics Corp., Comp. Gen. Dec. B-225432, Mar. 4, 1987, 87-1 CPD 1246; Yohar Supply Co., 66 Comp. Gen. 251 (1987

Performance Evaluation of Parallel Algorithms and Architectures in Concurrent Multiprocessor Systems

DTIC Science & Technology

1988-09-01

HEP and Other Parallel processors, Report no. ANL-83-97, Argonne National Laboratory, Argonne, Ill. 1983. [19] Davidson, G . S. A Practical Paradigm for...IEEE Comp. Soc., 1986. [241 Peir, Jih-kwon, and D. Gajski , "CAMP: A Programming Aide For Multiprocessors," Proc. 1986 ICPP, IEEE Comp. Soc., pp475...482. [251 Pfister, G . F., and V. A. Norton, "Hot Spot Contention and Combining in Multistage Interconnection Networks,"IEEE Trans. Comp., C-34, Oct

MetaComp: comprehensive analysis software for comparative meta-omics including comparative metagenomics.

PubMed

Zhai, Peng; Yang, Longshu; Guo, Xiao; Wang, Zhe; Guo, Jiangtao; Wang, Xiaoqi; Zhu, Huaiqiu

2017-10-02

During the past decade, the development of high throughput nucleic sequencing and mass spectrometry analysis techniques have enabled the characterization of microbial communities through metagenomics, metatranscriptomics, metaproteomics and metabolomics data. To reveal the diversity of microbial communities and interactions between living conditions and microbes, it is necessary to introduce comparative analysis based upon integration of all four types of data mentioned above. Comparative meta-omics, especially comparative metageomics, has been established as a routine process to highlight the significant differences in taxon composition and functional gene abundance among microbiota samples. Meanwhile, biologists are increasingly concerning about the correlations between meta-omics features and environmental factors, which may further decipher the adaptation strategy of a microbial community. We developed a graphical comprehensive analysis software named MetaComp comprising a series of statistical analysis approaches with visualized results for metagenomics and other meta-omics data comparison. This software is capable to read files generated by a variety of upstream programs. After data loading, analyses such as multivariate statistics, hypothesis testing of two-sample, multi-sample as well as two-group sample and a novel function-regression analysis of environmental factors are offered. Here, regression analysis regards meta-omic features as independent variable and environmental factors as dependent variables. Moreover, MetaComp is capable to automatically choose an appropriate two-group sample test based upon the traits of input abundance profiles. We further evaluate the performance of its choice, and exhibit applications for metagenomics, metaproteomics and metabolomics samples. MetaComp, an integrative software capable for applying to all meta-omics data, originally distills the influence of living environment on microbial community by regression analysis. Moreover, since the automatically chosen two-group sample test is verified to be outperformed, MetaComp is friendly to users without adequate statistical training. These improvements are aiming to overcome the new challenges under big data era for all meta-omics data. MetaComp is available at: http://cqb.pku.edu.cn/ZhuLab/MetaComp/ and https://github.com/pzhaipku/MetaComp/ .

Deformational behaviour of knee cartilage and changes in serum cartilage oligomeric matrix protein (COMP) after running and drop landing.

PubMed

Niehoff, A; Müller, M; Brüggemann, L; Savage, T; Zaucke, F; Eckstein, F; Müller-Lung, U; Brüggemann, G-P

2011-08-01

To investigate (1) the effect of running and drop landing interventions on knee cartilage deformation and serum cartilage oligomeric matrix protein (COMP) concentration and (2) if the changes in cartilage volume correlate with the changes in serum COMP level. Knee joint cartilage volume and thickness were determined using magnetic resonance imaging (MRI) as well as COMP concentration from serum samples before and after in vivo loading of 14 healthy adults (seven male and seven female). Participants performed different loading interventions of 30 min duration on three different days: (1) 100 vertical drop landings from a 73 cm high platform, (2) running at a velocity of 2.2m/s (3.96 km), and (3) resting on a chair. Blood samples were taken immediately before, immediately after and 0.5h, 1h, 2h and 3h post intervention. Pre- and post-loading coronal and axial gradient echo MR images with fat suppression were used to determine the patellar, tibial and femoral cartilage deformation. Serum COMP levels increased immediately after the running (+30.7%, pre: 7.3U/l, 95% confidence interval (CI): 5.6, 8.9, post: 9.1U/l, 95% CI: 7.2, 11.0, P=0.001) and after drop landing intervention (+32.3%, pre: 6.8U/l, 95% CI: 5.3, 8.4; post: 8.9U/l, 95% CI: 6.8, 10.9, P=0.001). Cartilage deformation was more pronounced after running compared to drop landing intervention, with being significant (volume: P=0.002 and thickness: P=0.001) only in the lateral tibia. We found a significant correlation (r(2)=0.599, P=0.001) between changes in serum COMP (%) and in cartilage volume (%) after the drop landing intervention, but not after running. In vivo exercise interventions differentially regulate serum COMP concentrations and knee cartilage deformations. The relation between changes in COMP and in cartilage volume seems to depend on both mechanical and biochemical factors. Copyright © 2011 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

compMS2Miner: An Automatable Metabolite Identification, Visualization, and Data-Sharing R Package for High-Resolution LC-MS Data Sets.

PubMed

Edmands, William M B; Petrick, Lauren; Barupal, Dinesh K; Scalbert, Augustin; Wilson, Mark J; Wickliffe, Jeffrey K; Rappaport, Stephen M

2017-04-04

A long-standing challenge of untargeted metabolomic profiling by ultrahigh-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) is efficient transition from unknown mass spectral features to confident metabolite annotations. The compMS 2 Miner (Comprehensive MS 2 Miner) package was developed in the R language to facilitate rapid, comprehensive feature annotation using a peak-picker-output and MS 2 data files as inputs. The number of MS 2 spectra that can be collected during a metabolomic profiling experiment far outweigh the amount of time required for pain-staking manual interpretation; therefore, a degree of software workflow autonomy is required for broad-scale metabolite annotation. CompMS 2 Miner integrates many useful tools in a single workflow for metabolite annotation and also provides a means to overview the MS 2 data with a Web application GUI compMS 2 Explorer (Comprehensive MS 2 Explorer) that also facilitates data-sharing and transparency. The automatable compMS 2 Miner workflow consists of the following steps: (i) matching unknown MS 1 features to precursor MS 2 scans, (ii) filtration of spectral noise (dynamic noise filter), (iii) generation of composite mass spectra by multiple similar spectrum signal summation and redundant/contaminant spectra removal, (iv) interpretation of possible fragment ion substructure using an internal database, (v) annotation of unknowns with chemical and spectral databases with prediction of mammalian biotransformation metabolites, wrapper functions for in silico fragmentation software, nearest neighbor chemical similarity scoring, random forest based retention time prediction, text-mining based false positive removal/true positive ranking, chemical taxonomic prediction and differential evolution based global annotation score optimization, and (vi) network graph visualizations, data curation, and sharing are made possible via the compMS 2 Explorer application. Metabolite identities and comments can also be recorded using an interactive table within compMS 2 Explorer. The utility of the package is illustrated with a data set of blood serum samples from 7 diet induced obese (DIO) and 7 nonobese (NO) C57BL/6J mice, which were also treated with an antibiotic (streptomycin) to knockdown the gut microbiota. The results of fully autonomous and objective usage of compMS 2 Miner are presented here. All automatically annotated spectra output by the workflow are provided in the Supporting Information and can alternatively be explored as publically available compMS 2 Explorer applications for both positive and negative modes ( https://wmbedmands.shinyapps.io/compMS2_mouseSera_POS and https://wmbedmands.shinyapps.io/compMS2_mouseSera_NEG ). The workflow provided rapid annotation of a diversity of endogenous and gut microbially derived metabolites affected by both diet and antibiotic treatment, which conformed to previously published reports. Composite spectra (n = 173) were autonomously matched to entries of the Massbank of North America (MoNA) spectral repository. These experimental and virtual (lipidBlast) spectra corresponded to 29 common endogenous compound classes (e.g., 51 lysophosphatidylcholines spectra) and were then used to calculate the ranking capability of 7 individual scoring metrics. It was found that an average of the 7 individual scoring metrics provided the most effective weighted average ranking ability of 3 for the MoNA matched spectra in spite of potential risk of false positive annotations emerging from automation. Minor structural differences such as relative carbon-carbon double bond positions were found in several cases to affect the correct rank of the MoNA annotated metabolite. The latest release and an example workflow is available in the package vignette ( https://github.com/WMBEdmands/compMS2Miner ) and a version of the published application is available on the shinyapps.io site ( https://wmbedmands.shinyapps.io/compMS2Example ).

Army Communicator. Volume 32, Number 1, Winter 2007

DTIC Science & Technology

2007-01-01

1, Winter 2007 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT...leader de- velopment is shifting from command- centric branch qualifying requirements to broader, less prescriptive, compe- tency-based experiences...able to move next summer may be offered an opportunity to broaden their career development by work - ing in another branch or functional area,” said

34 CFR 85.970 - Nonprocurement transaction.

Code of Federal Regulations, 2011 CFR

2011-07-01

... transaction, regardless of type (except procurement contracts), including, but not limited to the following... of Federal funds. (Authority: E.O. 12549 (3 CFR, 1986 Comp., p. 189); E.O 12689 (3 CFR, 1989 Comp., p...

34 CFR 85.970 - Nonprocurement transaction.

Code of Federal Regulations, 2010 CFR

2010-07-01

... transaction, regardless of type (except procurement contracts), including, but not limited to the following... of Federal funds. Authority: E.O. 12549 (3 CFR, 1986 Comp., p. 189); E.O 12689 (3 CFR, 1989 Comp., p...

Increased pentosidine, an advanced glycation end product, in serum and synovial fluid from patients with knee osteoarthritis and its relation with cartilage oligomeric matrix protein

PubMed Central

Senolt, L; Braun, M; Olejarova, M; Forejtova, S; Gatterova, J; Pavelka, K

2005-01-01

Background: Pentosidine, an advanced glycation end product, increasingly accumulates in articular cartilage with age, and contributes to the pathogenesis of osteoarthritis (OA). Increased pentosidine concentrations are associated with inflammatory disorders—for example, rheumatoid arthritis. Objective: To compare pentosidine serum concentrations in patients with knee OA and in healthy volunteers and to determine a relationship between pentosidine and cartilage oligomeric matrix protein (COMP)—a marker of articular cartilage destruction. Methods: Paired serum and synovial fluid samples were obtained by arthrocentesis from 38 patients with knee OA and from 38 healthy volunteers. Pentosidine concentration was measured by reverse phase high performance liquid chromatography with fluorescent detection and COMP was determined by sandwich ELISA. Results: Significantly increased serum pentosidine (p<0.01) and COMP (p<0.05) levels were detected in the patients with OA compared with the control group. Serum pentosidine correlated significantly with synovial fluid pentosidine (p<0.001). Pentosidine in synovial fluid (p<0.05) and in serum (p<0.05) correlated significantly with synovial fluid COMP. Pentosidine and COMP concentrations did not correlate significantly with the radiological stage of the disease. Conclusion: Increased pentosidine serum concentration in patients with OA and its correlation with the cartilage destruction marker COMP in synovial fluid suggests that pentosidine may be important in OA pathology and is a new potential OA marker. PMID:15897309

Mild Myopathy Is Associated with COMP but Not MATN3 Mutations in Mouse Models of Genetic Skeletal Diseases

PubMed Central

Piróg, Katarzyna A.; Katakura, Yoshihisa; Mironov, Aleksandr; Briggs, Michael D.

2013-01-01

Pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED) are skeletal disorders resulting from mutations in COMP, matrilin-3 or collagen IX and are characterised by short-limbed dwarfism and premature osteoarthritis. Interestingly, recent reports suggest patients can also manifest with muscle weakness. Here we present a detailed analysis of two mouse models of the PSACH/MED disease spectrum; ΔD469 T3-COMP (PSACH) and V194D matrilin-3 (MED). In grip test experiments T3-COMP mice were weaker than wild-type littermates, whereas V194D mice behaved as controls, confirming that short-limbed dwarfism alone does not contribute to PSACH/MED-related muscle weakness. Muscles from T3-COMP mice showed an increase in centronuclear fibers at the myotendinous junction. T3-COMP tendons became more lax in cyclic testing and showed thicker collagen fibers when compared with wild-type tissue; matrilin-3 mutant tissues were indistinguishable from controls. This comprehensive study of the myopathy associated with PSACH/MED mutations enables a better understanding of the disease progression, confirms that it is genotype specific and that the limb weakness originates from muscle and tendon pathology rather than short-limbed dwarfism itself. Since some patients are primarily diagnosed with neuromuscular symptoms, this study will facilitate better awareness of the differential diagnoses that might be associated with the PSACH/MED spectrum and subsequent care of PSACH/MED patients. PMID:24312420

Longitudinal documentation of serum cartilage oligomeric matrix protein and patient reported outcomes in collegiate soccer athletes over the course of an athletic season

PubMed Central

Hoch, Johanna M.; Mattacola, Carl G.; Bush, HeatherM.; McKeon, Jennifer Medina; Hewett, Timothy E.; Lattermann, Christian

2013-01-01

Background Serum cartilage oligomeric matrix protein (sCOMP) is a biomarker for cartilage degradation. Patient reported outcomes (PRO) are used to document post-injury recovery and may be used to prospectively identify changes in the course of a season. It is unknown what effect intense, continuous physical activity has on sCOMP levels and PRO values in athletes over the duration of a soccer season. Hypothesis/Purpose The purpose of this study was to longitudinally document sCOMP levels, and to determine if changes in PROs occur in collegiate soccer athletes during a season. The hypotheses tested were that sCOMP levels and PRO scores would remain stable over the duration of the spring soccer season. Study Design Case series; Level of evidence, 4. Methods 29 NCAA Division-I soccer athletes (18 males, 11 females, age:19.6±1.2 years, height:177.8±7.4cm, mass:73.8±10.2kg) participated in three[pre-(T1), mid-(T2), and post-season(T3)] data collection sessions. Subjects were included if they participated in the spring soccer season and were free of severe knee injury at the time of data collection. At each session subjects completed PROs (Lysholm, IKDC) before serum collection. Results For sCOMP(ng/mL) there was a significant effect for time with significant increases at T2(1723.5±257.9, p<0.0001) and T3(1624.7±231.6, p=0.002) when compared with T1(1482.9±217.9). For each of the PROs there was a significant effect for time with increases from T1-T2 and T2-T3. Conclusions These data indicate sCOMP levels increased as athletes reported an increased level of function over time. However, the differences in sCOMP levels did not reach the calculated MDC value and the differences in PRO scores did not reach previously calculated MDC values. It is unclear if these increases in sCOMP levels were due to an increase in cartilage matrix breakdown or turnover. Even though these elevations may not be clinically meaningful, this biomarker may have the potential to be used for future research studies investigating the effects of exercise on overall joint health in longitudinal studies. In addition, these results indicate fluctuations in sCOMP occur during a competitive season and must be taken into consideration for future biomarker studies. PMID:22967826

Changes in Cartilage Biomarker Levels During a Transcontinental Multistage Footrace Over 4486 km.

PubMed

Mündermann, Annegret; Klenk, Christopher; Billich, Christian; Nüesch, Corina; Pagenstert, Geert; Schmidt-Trucksäss, Arno; Schütz, Uwe

2017-09-01

Cartilage turnover and load-induced tissue changes are frequently assessed by quantifying concentrations of cartilage biomarkers in serum. To date, information on the effects of ultramarathon running on articular cartilage is scarce. Serum concentrations of cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-1, MMP-3, MMP-9, COL2-3/4C long mono (C2C), procollagen type II C-terminal propeptide (CPII), and C2C:CPII will increase throughout a multistage ultramarathon. Descriptive laboratory study. Blood samples were collected from 36 runners (4 female; mean age, 49.0 ± 10.7 years; mean body mass index, 23.1 ± 2.3 kg/m 2 [start] and 21.4 ± 1.9 kg/m 2 [finish]) before (t 0 ) and during (t 1 : 1002 km; t 2 : 2132 km; t 3 : 3234 km; t 4 : 4039 km) a 4486-km multistage ultramarathon. Serum COMP, MMP-1, MMP-3, MMP-9, C2C, and CPII levels were assessed using commercial enzyme-linked immunosorbent assays. Linear mixed models were used to detect significant changes in serum biomarker levels over time with the time-varying covariates of body weight, running speed, and daily running time. Serum concentrations of COMP, MMP-9, and MMP-3 changed significantly throughout the multistage ultramarathon. On average, concentrations increased during the first measurement interval (MI1: t 1 -t 0 ) by 22.5% for COMP (95% CI, 0.29-0.71 ng/mL), 22.3% for MMP-3 (95% CI, 0.24-15.37 ng/mL), and 95.6% for MMP-9 (95% CI, 81.7-414.5 ng/mL) and remained stable throughout MI2, MI3, and MI4. Serum concentrations of MMP-1, C2C, CPII, and C2C:CPII did not change significantly throughout the multistage ultramarathon. Changes in MMP-3 were statistically associated with changes in COMP throughout the ultramarathon race (MMP-3: Wald Z = 3.476, P = .001). Elevated COMP levels indicate increased COMP turnover in response to extreme running, and the association between load-induced changes in MMP-3 and changes in COMP suggests the possibility that MMP-3 may be involved in the degradation of COMP. These results suggest that articular cartilage is able to adapt even to extreme physical activity, possibly explaining why the risk of degenerative joint disease is not elevated in the running population.

ISPATOM: A Generic Real-Time Data Processing Tool Without Programming

NASA Technical Reports Server (NTRS)

Dershowitz, Adam

2007-01-01

Information Sharing Protocol Advanced Tool of Math (ISPATOM) is an application program allowing for the streamlined generation of comps, which subscribe to streams of incoming telemetry data, perform any necessary computations on the data, then send the data to other programs for display and/or further processing in NASA mission control centers. Heretofore, the development of comps was difficult, expensive, and time-consuming: Each comp was custom written manually, in a low-level computing language, by a programmer attempting to follow requirements of flight controllers. ISPATOM enables a flight controller who is not a programmer to write a comp by simply typing in one or more equation( s) at a command line or retrieving the equation(s) from a text file. ISPATOM then subscribes to the necessary input data, performs all of necessary computations, and sends out the results. It sends out new results whenever the input data change. The use of equations in ISPATOM is no more difficult than is entering equations in a spreadsheet. The time involved in developing a comp is thus limited to the time taken to decide on the necessary equations. Thus, ISPATOM is a real-time dynamic calculator.

Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women

PubMed Central

Kluzek, Stefan; Bay-Jensen, Anne-Christine; Judge, Andrew; Karsdal, Morten A.; Shorthose, Matthew; Spector, Tim; Hart, Deborah; Newton, Julia L.; Arden, Nigel K.

2015-01-01

Abstract Context and objective: We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 years on the development of radiographic (RKOA) and painful knee osteoarthritis (KOA) in a longitudinal cohort of middle-aged women. Materials and methods: Five hundred and ninety-three women with no baseline KOA underwent 5-year knee radiographs over 20-years and were asked about knee pain a month before each assessment. A repeated measures logistic regression model was used where the outcomes were recorded at 5, 10, 15 and 20-years follow-up. Results: The highest quartile of sCOMP was associated with increased risk of RKOA with overall OR of 1.97 (95% CI: 1.33–2.91) over 20 years when compared with the lowest sCOMP quartile. The association with painful KOA was similar and also independent, but only when the fourth and third sCOMP quartiles were compared. Discussion and conclusion: This study demonstrates that sCOMP levels are predictive of subsequent structural changes and incidence of painful KOA, independently of age and BMI. PMID:26848781

Structure Identification Using the US EPA's CompTox Chemistry Dashboard (CompTox CoP)

EPA Science Inventory

Community of practice webinar presentation on the Identification of unknowns in non-targeted analyses (NTA) requires the integration of complementary data types to generate a confident consensus structure.

Intracavernous Delivery of a Designed Angiopoietin-1 Variant Rescues Erectile Function by Enhancing Endothelial Regeneration in the Streptozotocin-Induced Diabetic Mouse

PubMed Central

Jin, Hai-Rong; Kim, Woo Jean; Song, Jae Sook; Piao, Shuguang; Choi, Min Ji; Tumurbaatar, Munkhbayar; Shin, Sun Hwa; Yin, Guo Nan; Koh, Gou Young; Ryu, Ji-Kan; Suh, Jun-Kyu

2011-01-01

OBJECTIVE Patients with diabetic erectile dysfunction often have severe endothelial dysfunction and respond poorly to oral phosphodiesterase-5 inhibitors. We examined the effectiveness of the potent angiopoietin-1 (Ang1) variant, cartilage oligomeric matrix protein (COMP)-Ang1, in promoting cavernous endothelial regeneration and restoring erectile function in diabetic animals. RESEARCH DESIGN AND METHODS Four groups of mice were used: controls; streptozotocin (STZ)-induced diabetic mice; STZ-induced diabetic mice treated with repeated intracavernous injections of PBS; and STZ-induced diabetic mice treated with COMP-Ang1 protein (days −3 and 0). Two and 4 weeks after treatment, we measured erectile function by electrical stimulation of the cavernous nerve. The penis was harvested for histologic examinations, Western blot analysis, and cGMP quantification. We also performed a vascular permeability test. RESULTS Local delivery of the COMP-Ang1 protein significantly increased cavernous endothelial proliferation, endothelial nitric oxide (NO) synthase (NOS) phosphorylation, and cGMP expression compared with that in the untreated or PBS-treated STZ-induced diabetic group. The changes in the group that received COMP-Ang1 restored erectile function up to 4 weeks after treatment. Endothelial protective effects, such as marked decreases in the expression of p47phox and inducible NOS, in the generation of superoxide anion and nitrotyrosine, and in the number of apoptotic cells in the corpus cavernosum tissue, were noted in COMP-Ang1–treated STZ-induced diabetic mice. An intracavernous injection of COMP-Ang1 completely restored endothelial cell-cell junction proteins and decreased cavernous endothelial permeability. COMP-Ang1–induced promotion of cavernous angiogenesis and erectile function was abolished by the NOS inhibitor, N-nitro-L-arginine methyl ester, but not by the NADPH oxidase inhibitor, apocynin. CONCLUSIONS These findings support the concept of cavernous endothelial regeneration by use of the recombinant Ang1 protein as a curative therapy for diabetic erectile dysfunction. PMID:21270241

Effects of nitrate and phosphate supply on chromophoric and fluorescent dissolved organic matter in the Eastern Tropical North Atlantic: a mesocosm study

NASA Astrophysics Data System (ADS)

Loginova, A. N.; Borchard, C.; Meyer, J.; Hauss, H.; Kiko, R.; Engel, A.

2015-12-01

In open-ocean regions, as is the Eastern Tropical North Atlantic (ETNA), pelagic production is the main source of dissolved organic matter (DOM) and is affected by dissolved inorganic nitrogen (DIN) and phosphorus (DIP) concentrations. Changes in pelagic production under nutrient amendments were shown to also modify DOM quantity and quality. However, little information is available about the effects of nutrient variability on chromophoric (CDOM) and fluorescent (FDOM) DOM dynamics. Here we present results from two mesocosm experiments ("Varied P" and "Varied N") conducted with a natural plankton community from the ETNA, where the effects of DIP and DIN supply on DOM optical properties were studied. CDOM accumulated proportionally to phytoplankton biomass during the experiments. Spectral slope (S) decreased over time indicating accumulation of high molecular weight DOM. In Varied N, an additional CDOM portion, as a result of bacterial DOM reworking, was determined. It increased the CDOM fraction in DOC proportionally to the supplied DIN. The humic-like FDOM component (Comp.1) was produced by bacteria proportionally to DIN supply. The protein-like FDOM component (Comp.2) was released irrespectively to phytoplankton or bacterial biomass, but depended on DIP and DIN concentrations. Under high DIN supply, Comp.2 was removed by bacterial reworking, leading to an accumulation of humic-like Comp.1. No influence of nutrient availability on amino acid-like FDOM component in peptide form (Comp.3) was observed. Comp.3 potentially acted as an intermediate product during formation or degradation of Comp.2. Our findings suggest that changes in nutrient concentrations may lead to substantial responses in the quantity and quality of optically active DOM and, therefore, might bias results of the applied in situ optical techniques for an estimation of DOC concentrations in open-ocean regions.

COMP-1 promotes competitive advantage of nematode sperm.

PubMed

Hansen, Jody M; Chavez, Daniela R; Stanfield, Gillian M

2015-03-19

Competition among sperm to fertilize oocytes is a ubiquitous feature of sexual reproduction as well as a profoundly important aspect of sexual selection. However, little is known about the cellular mechanisms sperm use to gain competitive advantage or how these mechanisms are regulated genetically. In this study, we utilize a forward genetic screen in Caenorhabditis elegans to identify a gene, comp-1, whose function is specifically required in competitive contexts. We show that comp-1 functions in sperm to modulate their migration through and localization within the reproductive tract, thereby promoting their access to oocytes. Contrary to previously described models, comp-1 mutant sperm show no defects in size or velocity, thereby defining a novel pathway for preferential usage. Our results indicate not only that sperm functional traits can influence the outcome of sperm competition, but also that these traits can be modulated in a context-dependent manner depending on the presence of competing sperm.

Maternal ADHD, parenting, and psychopathology among mothers of adolescents with ADHD

PubMed Central

Babinski, Dara E.; Pelham, William E.; Molina, Brooke S.G.; Gnagy, Elizabeth M.; Waschbusch, Daniel A.; Wymbs, Brian T.; Sibley, Margaret H.; Derefinko, Karen J.; Kuriyan, Aparajita B.

2012-01-01

Objective This study describes the parenting and psychopathology of mothers with ADHD of adolescents with ADHD (MCA), non-ADHD mothers of adolescents with ADHD (CA), and non-ADHD mothers of adolescents without ADHD (COMP). Method Two sets of pairwise comparisons: 1) COMP vs. CA and 2) CA vs. MCA were conducted. We hypothesized that CA would experience greater distress in parenting and psychopathology compared to COMP, and that MCA would experience even more impairment compared to CA. Results Few differences emerged in comparisons of CA and COMP, with the exception of CA reporting greater parent-adolescent conflict and internalizing problems. In contrast, differences consistently emerged in comparisons of MCA and CA showing more difficulty for MCA in parenting and psychopathology. Conclusion These findings underscore the need for treatments that address parental ADHD when adolescent ADHD is the intended target. PMID:23160485

The Earth System Prediction Suite: Toward a Coordinated U.S. Modeling Capability

DTIC Science & Technology

2015-01-01

517 regional information products ( Goodall et al. 2013). 518 A critical aspect of future work is the evaluation and evolution of NUOPC and ESMF...Atmosphere (NUMA). SIAM J. Sci. Comp. 35(5), B1162-700 B1194. 701 Goodall , J. L., K. D. Saint, M. B. Ercan, L. J. Baily, S. Murphy, C. DeLuca, R. B

77 FR 64581 - Petition for Exemption; Summary of Petition Received

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-22

... operate their turbo-jet powered Comp-Let TST-14 glider without completing within the preceding 12 calendar..., complete a pilot-in-command proficiency check in the turbo-jet powered Comp-Let TST-14 glider. [FR Doc...

Evaluation of a simple test of reaction time for baseline concussion testing in a population of high school athletes.

PubMed

MacDonald, James; Wilson, Julie; Young, Julie; Duerson, Drew; Swisher, Gail; Collins, Christy L; Meehan, William P

2015-01-01

A common sequela of concussions is impaired reaction time. Computerized neurocognitive tests commonly measure reaction time. A simple clinical test for reaction time has been studied previously in college athletes; whether this test is valid and reliable when assessing younger athletes remains unknown. Our study examines the reliability and validity of this test in a population of high school athletes. Cross-sectional study. Two American High Schools. High school athletes (N = 448) participating in American football or soccer during the academic years 2011 to 2012 and 2012 to 2013. All study participants completed a computerized baseline neurocognitive assessment that included a measure of reaction time (RT comp), in addition to a clinical measure of reaction time that assessed how far a standard measuring device would fall prior to the athlete catching it (RT clin). Validity was assessed by determining the correlation between RT clin and RT comp. Reliability was assessed by measuring the intraclass correlation coefficients (ICCs) between the repeated measures of RT clin and RT comp taken 1 year apart. In the first year of study, RT clin and RT comp were positively but weakly correlated (rs = 0.229, P < 0.001). In the second year, there was no significant correlation between RT clin and RT comp (rs = 0.084, P = 0.084). Both RT clin [ICC = 0.608; 95% confidence interval (CI), 0.434-0.728] and RT comp (ICC = 0.691; 95% CI, 0.554-0.786) had marginal reliability. In a population of high school athletes, RT clin had poor validity when compared with RT comp as a standard. Both RT clin and RT comp had marginal test-retest reliability. Before considering the clinical use of RT clin in the assessment of sport-related concussions sustained by high school athletes, the factors affecting reliability and validity should be investigated further. Reaction time impairment commonly results from concussion and is among the most clinically important measures of the condition. The device evaluated in this study has previously been investigated as a reaction time measure in college athletes. This study investigates the clinical generalizability of the device in a younger population. A video abstract showing how the RT clin device is used in practice is available as Supplemental Digital Content 1, http://links.lww.com/JSM/A43.

CompTox Chemistry Dashboard webinar

EPA Pesticide Factsheets

The CompTox Chemistry Dashboard is part of a suite of dashboards developed by EPA to help evaluate the safety of chemicals. The dashboard provides access to a variety of information on over 700,000 chemicals currently in use. Within the application, users

SEMModComp: An R Package for Calculating Likelihood Ratio Tests for Mean and Covariance Structure Models

ERIC Educational Resources Information Center

Levy, Roy

2010-01-01

SEMModComp, a software package for conducting likelihood ratio tests for mean and covariance structure modeling is described. The package is written in R and freely available for download or on request.

Effect of ginger, Paullinia cupana, muira puama and l- citrulline, singly or in combination, on modulation of the inducible nitric oxide- NO-cGMP pathway in rat penile smooth muscle cells.

PubMed

Ferrini, Monica G; Garcia, Eduardo; Abraham, Andrea; Artaza, Jorge N; Nguyen, Sabine; Rajfer, Jacob

2018-06-01

COMP-4 is a natural compound-based dietary supplement consisting of the combination of ginger, Paullinia cupana, muira puama and l-citrulline, which when given long-term has been shown in the aged rat to a) upregulate iNOS in the penile smooth muscle cells (SMC), b) reverse the corporal SMC apoptosis and fibrosis associated with corporal veno-occlusive dysfunction (CVOD), and c) improve resulting erectile function. To elucidate the mechanism of how COMP-4 and its individual components modulate the iNOS-cGMP pathway, an in vitro study was conducted using a rat corporal primary SMC culture to determine its effect on NOS, soluble guanylate cyclase (sGC), cGMP and the phosphodiesterase 5 enzyme (PDE5). Primary SMC cultures using the explant technique were initiated by cutting small pieces of corporal tissue from 8 week old Sprague-Dawley rats. The SMC were grown in Dulbecco media with 20% fetal calf serum. The SMC were then incubated with or without COMP-4 (0.69 mg/ml) or its ingredients alone (ginger: 0.225 mg/ml; muira puama, Paullinia cupana and l-citrulline each at 0.9 mg/ml) for up to 24 h mRNA and protein were extracted and used for the determination of NOS, sGC and PDE5 content. cGMP content was determined by ELISA. L-NIL (4 μM) was used as an inhibitor of iNOS activity. Compared to the control values, COMP-4 upregulated expression of cGMP by 85%, induced a 42 fold increase in sGC as well as a 15 fold increase in both iNOS protein and mRNA content while it decreased both PDE5 mRNA and protein content each by about 50%. L-NIL completely inhibited the effect of COMP-4 on cGMP production. When compared with each of the individual four components of COMP-4, it appears that COMP-4 itself had the most profound effect in modulating each one the specific steps within the iNOS-cGMP pathway. This in vitro study demonstrates that COMP-4 is capable of activating the endogenous cellular iNOS-cGMP pathway within the CSM cells, which is theorized to be responsible for reducing the fibrosis and apoptosis as well as the CVOD observed in the aging rat penis. Further studies will be necessary in order to determine whether supplementation of COMP-4 on a daily basis may be beneficial in halting or reversing this aging related erectile dysfunction in the clinical setting. Copyright © 2018 Elsevier Inc. All rights reserved.

Genetic Variation in the Vesicular Monoamine Transporter: Preliminary associations with Cognitive Outcomes after Severe Traumatic Brain Injury

PubMed Central

Markos, Steven; Failla, Michelle D.; Ritter, Anne C; Dixon, C. Edward; Conley, Yvette P.; Ricker, Joseph H; Arenth, Patricia M.; Juengst, Shannon B.; Wagner, Amy K.

2015-01-01

Introduction Traumatic brain injury (TBI) frequently results in impaired cognition, a function that can be modulated by monoaminergic signaling. Genetic variation among monoaminergic genes may affect post-TBI cognitive performance. The vesicular monoamine transporter 2 (VMAT2) gene may be a novel source of genetic variation important for cognitive outcomes post-TBI given VMAT2’s role in monoaminergic neurotransmission. Objective Evaluate associations between VMAT2 variability and cognitive outcomes post-TBI. Methods We evaluated 136 white adults with severe TBI for variation in VMAT2 using a tagging single nucleotide polymorphism (tSNP) approach (rs363223, rs363226, rs363251, and rs363341). We show genetic variation interacts with assessed cognitive impairment [cognitive composite T-scores (Comp-Cog)] to influence functional cognition [Functional Independence Measure Cognitive subscale (FIM-Cog)] 6 and 12 months post-injury. Results Multivariate analyses at 6-months post-injury showed rs363226 genotype was associated with Comp-Cog (p=0.040) and interacted with Comp-Cog to influence functional cognition (p<0.001). G-homozygotes had the largest cognitive impairment, and their cognitive impairment had the greatest adverse effect on functional cognition. Discussion We provide the first evidence that genetic variation within VMAT2 is associated with cognitive outcomes following TBI. Further work is needed to validate this finding and elucidate mechanisms by which genetic variation affects monoaminergic signaling, mediating differences in cognitive outcomes. PMID:26828714

DEVELOPING COMPUTATIONAL TOOLS FOR PREDICTING CHEMICAL FATE, METABOLISM, AND TOXICITY PATHWAYS

EPA Science Inventory

ORD's research program in Computational Toxicology (CompTox) will enable EPA Program Offices and other regulators to prioritize and reduce toxicity-testing requirements for potentially hazardous chemicals. The CompTox program defines the "toxicity process" as follows : 1) a stre...

75 FR 15736 - Investigations Regarding Certifications of Eligibility To Apply for Worker Adjustment Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-30

... Kansas City, MO....... 02/22/10 02/10/10 Pharmaceuticals (Comp). 73543 Bumble Bee Foods, LLC (Comp..., Siemens World Boise, ID 02/24/10 02/23/10 Travel (Wkrs). 73561 Musashi Auto Parts (State).. Battle Creek...

20180318 - Using the US EPA's CompTox Chemistry Dashboard for structure identification and non-targeted analyses (ACS Spring)

EPA Science Inventory

The CompTox Chemistry Dashboard provides access to data for ~760,000 chemicals. High quality curated data and rich metadata facilitates mass spec analysis. “MS-Ready” processed data enables structure identification.

Clinical Investigation Program RCS MED-300 (R1).

DTIC Science & Technology

1985-09-30

of Group A Streptococcus ......................................... 193 Work Unit No. 85/17 (FY85,T) Serological Survey of Epstein - Barr Virus ...Prot No: 85/17 Status: Terminated Title: Serological Survey of Epstein - Barr Virus Infections Followed Over a 12-Month Period Start Date: Est Comp Date...Principal Investigator: Facility: CPT C.A. Borchert, MC Dept/Sec: Pediatrics Assoc Investigators Key Words: Epstein - Barr Virus Accumulative MEDCASE Est

Leukotriene B4 induces EMT and vimentin expression in PANC-1 pancreatic cancer cells: Involvement of BLT2 via ERK2 activation.

PubMed

Kim, You Ri; Park, Mi Kyung; Kang, Gyeong Jin; Kim, Hyun Ji; Kim, Eun Ji; Byun, Hyun Jung; Lee, Moo-Yeol; Lee, Chang Hoon

2016-12-01

Leukotriene B 4 (LTB 4 ) is a leukocyte chemoattractant and plays a major role controlling inflammatory responses including pancreatitis. LTB 4 is known to be correlated with cancer progression. LTB 4 induces keratin phosphorylation and reorganization by activating extracellular regulated kinase (ERK) in PANC-1 pancreatic cancer cell lines. However, the role of LTB 4 in epithelial mesenchymal transition (EMT) and vimentin expression in pancreatic cancer cells is unknown. We examined whether LTB 4 induces EMT and vimentin expression by Western blot, si-RNA, and RT-PCR. LTB 4 induced morphological change, decreased E-cadherin expression and increased N-cadherin and vimentin expression. LTB4 increased migration and invasion of PANC-1 cancer cells. LTB 4 dose-dependently upregulated expression of vimentin in PANC-1 cancer cells. LTB 4 -induced vimentin expression was suppressed by LY255283 (BLT2 antagonist). Comp A, a BLT2 agonist, further increased vimentin expression. Gene silencing of BLT2 suppressed LTB 4 -or Comp A-induced vimentin expression in PANC-1 cells. The MEK inhibitor, PD98059 suppressed Comp A-induced vimentin expression. Comp A or transfection of plasmid containing BLT2 cDNA (pC BLT2 ) activated ERK, and BLT2 gene silencing suppressed Comp A-induced ERK activation. ERK2 siRNA abrogated Comp A-induced vimentin expression and ERK2 overexpression enhanced vimentin expression. One of well-known cause of ras mutation, cigarette smoke extracts increased BLT2 expression in PANC-1 cancer cells. Taken together, these results suggest that BLT2 is involved in LTB 4 -induced vimentin expression through ERK2 in PANC-1 cells. Copyright © 2016 Elsevier Ltd. All rights reserved.

Effects of Arnica comp.-Heel® on reducing cardiovascular events in patients with stable coronary disease.

PubMed

Fioranelli, Massimo; Bianchi, Maria; Roccia, Maria G; Di Nardo, Veronica

2016-02-01

The purpose of the study was to evaluate the effectiveness of the treatment with one tablet a day of a low dose multicomponent medication (Arnica comp.-Heel® tablets) with anti-inflammatory properties in order to reduce the risk of cardiovascular events in patients with clinically stable coronary disease. The presence of inflammatory cells in atherosclerotic plaques of patients with stable coronary disease indicates the possibility to act by inhibiting the inflammatory phenomenon with Arnica comp.-Heel® tablets reducing the risk of instability of the plaque and, consequently, improving the clinical outcome in patients with stable coronary disease. Within this retrospective observational spontaneous clinical study 44 patients (31 males and 13 females) all presenting stable coronary artery disease were evaluated; 25 subjects were treated with only acetylsalicylic acid and/or clopidogrel in association with statins (standard therapeutic protocol) while for the other 18 subjects the standard therapeutic protocol was integrated with Arnica comp.-Heel® (one sublingual tablet/day). The primary outcome was to evaluate the incidence of acute coronary syndrome, out-of-hospital cardiac arrest, or non-cardioembolic ischemic stroke. The evaluation of the primary outcome showed that in the group of patients (18) who received the standard therapeutic protocol plus Arnica comp.-Heel® only one cardiovascular event was registered (5.6%) while in the group treated only with standard therapy 4 events were recorded in 25 patients (16%). The treatment with Arnica comp.-Heel® (one tablet/day) in combination with standard therapies for secondary prevention is effective in reducing the incidence of cardiovascular events in patients with stable coronary artery disease.

The effect of vigorous running and cycling on serum COMP, lubricin, and femoral cartilage thickness: a pilot study.

PubMed

Roberts, Harry M; Moore, Jonathan P; Griffith-McGeever, Claire L; Fortes, Matthew B; Thom, Jeanette M

2016-08-01

Our aim was to investigate lubricin, cartilage oligomeric matrix protein (COMP), and femoral cartilage deformation in response to different biomechanical loading of the knee joint (running vs cycling). Serum lubricin and COMP concentrations (enzyme-linked immunosorbent assay), and femoral cartilage thickness (suprapatellar transverse ultrasonography) were determined in 11 male runners (age: 40 ± 6 years; weight: 76 ± 8 kg) and 11 male cyclists (35 ± 12 years; 75 ± 5 kg) at baseline, immediately after, and 30 min after vigorous exercise (time trial: 10-km run or 25-km cycle). At baseline, lubricin (runners: 104.0 ± 19.8 ng/ml; cyclists: 119.1 ± 23.9 ng/ml) and COMP (runners: 804.1 ± 87.5 ng/ml; cyclists: 693.0 ± 84.7 ng/ml) did not significantly differ; however, vigorous exercise was accompanied by an increase in lubricin (cyclists: 39.4 %; p < 0.05; runners: 56.9 %; p < 0.05) and COMP (cyclists: 32.1 %; p < 0.05; runners: 14.2 %; p = 0.14) that returned toward baseline following 30 min of rest (p < 0.05). No between-group differences were observed for baseline cartilage thickness at the intercondyle notch, medial condyle, and lateral condyle, and vigorous exercise did not result in significant change for either group. In the absence of ultrasonographic knee cartilage deformation, the response of serum lubricin and COMP following acute vigorous exercise indicates an increase in joint lubrication and cartilage metabolism, respectively, which appears largely independent of exercise modality.

Coronal multichannel polarimeter for Lomnický štít Observatory. (Slovak Title: Koronálny multikanálový polarimeter pre observatórium Lomnický štít)

NASA Astrophysics Data System (ADS)

Rybák, J.; Ambróz, J.; Gömöry, P.; Kozák, M.; Kučera, A.; Tomczyk, S.; Sewell, S.; Summers, R.; Sutherland, L.; Watt, A.

2010-12-01

The contribution presents the process of development and preparation of the Coronal Multi-channel Polarimeter (COMP-S) for the Lomnický štít Observatory of the SAS Astronomy Institute. The design of the device is based on the experience gained in recent years with the CoMP (High Altitude Observatory / NCAR; Boulder, USA) instrument. The device will be a combination of two main optical components: the Lyot tunable filter and polarimeter, and is prepared specifically for one of the 20 cm Zeiss coronagraph at the Lomnický štít Observatory where it will be installed in 2011. CoMP-S will differ from its predecessor in several respects. The most important difference is that CoMP-S will be able to observe the corona and chromospheric emission lines in the wavelength range from 530 to 1083 nm. This feature will be achieved using superachromatic wave plates and dichroic polarizers with wide bandwidth. Furthermore, in the CoMP-S instrument new SWIFT liquid crystals of Meadowlark Optics company will be used as variable retarders instead of nematic liquid crystal retarders (LCVR) which will considerably shorten the measuring process. Ferroelectric liquid crystals will provide measurements of the full Stokes vector with nearly optimal polarization throughout the whole instrument bandwidth. Recently developed sCMOS cameras are to provide diffraction limit resolution of observations, with the 860x680 arc second field and 30-frames-per-second cadence. The device will be used in the Astronomical Observatory of SAS at Lomnický štít primarily for spectrum polarimetry of prominences and coronal loops of the active solar regions.

COMP (Computerized Operational Materials Prescription).

ERIC Educational Resources Information Center

Rosenkranz, Catherine I.

Described is Project COMP (Computerized Operational Materials Prescription), an individualized reading instructional program for educable mentally retarded (EMR) children in regular or special classes. The program is designed to correlate with the Wisconsin Design for Reading (WDR) and to utilize a diagnostic teaching specialist who uses specific…

Measuring Impact of EPAs Computational Toxicology Research (BOSC)

EPA Science Inventory

Computational Toxicology (CompTox) research at the EPA was initiated in 2005. Since 2005, CompTox research efforts have made tremendous advances in developing new approaches to evaluate thousands of chemicals for potential health effects. The purpose of this case study is to trac...

Effect of resistance training with vibration and compression on the formation of muscle and bone.

PubMed

Zinner, Christoph; Baessler, Bettina; Weiss, Kilian; Ruf, Jasmine; Michels, Guido; Holmberg, Hans-Christer; Sperlich, Billy

2017-12-01

In this study we investigated the effects of resistance training with vibration in combination with leg compression to restrict blood flow on strength, muscle oxygenation, muscle mass, and bone formation. Twelve participants were tested before and after 12 weeks of resistance training with application of vibration (VIBRA; 1-2 mm, 30 Hz) to both legs and compression (∼35 mm Hg, VIBRA+COMP) to only 1 leg. VIBRA+COMP and VIBRA improved 1 repetition maximum (1-RM), increased the number of repetitions preceding muscle exhaustion, enhanced cortical bone mass, and lowered the mass and fat fraction in the thigh, with no changes in total muscle mass. The mass of cancellous bone decreased to a similar extent after VIBRA and VIBRA+COMP. Resistance training with VIBRA+COMP and VIBRA improved 1-RM, increased the number of repetitions preceding muscular exhaustion, and enhanced formation of cortical bone, with no alteration of muscle mass. Muscle Nerve 56: 1137-1142, 2017. © 2017 Wiley Periodicals, Inc.

COMP-1 promotes competitive advantage of nematode sperm

PubMed Central

Hansen, Jody M; Chavez, Daniela R; Stanfield, Gillian M

2015-01-01

Competition among sperm to fertilize oocytes is a ubiquitous feature of sexual reproduction as well as a profoundly important aspect of sexual selection. However, little is known about the cellular mechanisms sperm use to gain competitive advantage or how these mechanisms are regulated genetically. In this study, we utilize a forward genetic screen in Caenorhabditis elegans to identify a gene, comp-1, whose function is specifically required in competitive contexts. We show that comp-1 functions in sperm to modulate their migration through and localization within the reproductive tract, thereby promoting their access to oocytes. Contrary to previously described models, comp-1 mutant sperm show no defects in size or velocity, thereby defining a novel pathway for preferential usage. Our results indicate not only that sperm functional traits can influence the outcome of sperm competition, but also that these traits can be modulated in a context-dependent manner depending on the presence of competing sperm. DOI: http://dx.doi.org/10.7554/eLife.05423.001 PMID:25789512

Star Excursion Balance Test Performance Varies by Sport in Healthy Division I Collegiate Athletes.

PubMed

Stiffler, Mikel R; Sanfilippo, Jennifer L; Brooks, M Alison; Heiderscheit, Bryan C

2015-10-01

Cross-sectional. To describe performance and asymmetry on the Star Excursion Balance Test (SEBT) by sex and sport, and to determine if differences exist within a collegiate athlete population. Performance on the SEBT may differ between sexes and levels of competition, though the results of previous studies have been inconsistent. Investigation of performance and asymmetry differences between sports is limited. Sex- and sport-specific reference values likely need to be determined to best assess SEBT performance. Performance on the SEBT was retrospectively reviewed in 393 healthy National Collegiate Athletic Association Division I collegiate athletes from 8 sports. Means, standard deviations, and 95% confidence intervals were calculated for all variables. Normalized reach distance (percent limb length) and asymmetry between limbs were compared for the anterior (ANT), posterolateral (PL), and posteromedial (PM) directions and for the composite (COMP) score using a 2-way analysis of variance (ANOVA) of sex by sport, and a 1-way ANOVA to separately compare sports within each sex. Average normalized reach distance ranged from 62% to 69%, 84% to 97%, and 99% to 113% in the ANT, PL, and PM directions, respectively, and from 82% to 92% in the COMP score. Normalized asymmetry ranged from 3% to 4%, 5% to 8%, and 5% to 6% in the ANT, PL, and PM directions, respectively. A significant sex-by-sport interaction (P = .039) was observed in the ANT direction, with a sex effect for soccer players (P<.001; men less than women). Significant differences were observed in the PL and PM directions and in the COMP score among women's teams, with women's ice hockey players reaching the farthest (COMP, 90.0%). Among men's teams, significant differences were observed in all directions and in the COMP score. Men's ice hockey players (COMP, 91.9%) and wrestlers achieved the farthest distances (COMP, 88.8%). Performance on the SEBT varies by team, with a difference between sexes also present for soccer. Performance on the SEBT and potential injury risk should be interpreted within the context of the athlete's sport.

Effect of Exercise-Induced Enhancement of the Leg-Extensor Muscle-Tendon Unit Capacities on Ambulatory Mechanics and Knee Osteoarthritis Markers in the Elderly

PubMed Central

Karamanidis, Kiros; Oberländer, Kai Daniel; Niehoff, Anja; Epro, Gaspar; Brüggemann, Gert-Peter

2014-01-01

Objective Leg-extensor muscle weakness could be a key component in knee joint degeneration in the elderly because it may result in altered muscular control during locomotion influencing the mechanical environment within the joint. This work aimed to examine whether an exercise-induced enhancement of the triceps surae (TS) and quadriceps femoris (QF) muscle-tendon unit (MTU) capacities would affect mechanical and biological markers for knee osteoarthritis in the elderly. Methods Twelve older women completed a 14-week TS and QF MTU exercise intervention, which had already been established as increasing muscle strength and tendon stiffness. Locomotion mechanics and serum cartilage oligomeric matrix protein (COMP) levels were examined during incline walking. MTU mechanical properties were assessed using simultaneously ultrasonography and dynamometry. Results Post exercise intervention, the elderly had higher TS and QF contractile strength and tendon-aponeurosis stiffness. Regarding the incline gait task, the subjects demonstrated a lower external knee adduction moment and lower knee adduction angular impulse during the stance phase post-intervention. Furthermore, post-intervention compared to pre-intervention, the elderly showed lower external hip adduction moment, but revealed higher plantarflexion pushoff moment. The changes in the external knee adduction moment were significantly correlated with the improvement in ankle pushoff function. Serum COMP concentration increased in response to the 0.5-h incline walking exercise with no differences in the magnitude of increment between pre- and post-intervention. Conclusions This work emphasizes the important role played by the ankle pushoff function in knee joint mechanical loading during locomotion, and may justify the inclusion of the TS MTU in prevention programs aiming to positively influence specific mechanical markers for knee osteoarthritis in the elderly. However, the study was unable to show that COMP is amenable to change in the elderly following a 14-week exercise intervention and, therefore, the physiological benefit of improved muscle function for knee cartilage requires further investigation. PMID:24905024

Effect of exercise-induced enhancement of the leg-extensor muscle-tendon unit capacities on ambulatory mechanics and knee osteoarthritis markers in the elderly.

PubMed

Karamanidis, Kiros; Oberländer, Kai Daniel; Niehoff, Anja; Epro, Gaspar; Brüggemann, Gert-Peter

2014-01-01

Leg-extensor muscle weakness could be a key component in knee joint degeneration in the elderly because it may result in altered muscular control during locomotion influencing the mechanical environment within the joint. This work aimed to examine whether an exercise-induced enhancement of the triceps surae (TS) and quadriceps femoris (QF) muscle-tendon unit (MTU) capacities would affect mechanical and biological markers for knee osteoarthritis in the elderly. Twelve older women completed a 14-week TS and QF MTU exercise intervention, which had already been established as increasing muscle strength and tendon stiffness. Locomotion mechanics and serum cartilage oligomeric matrix protein (COMP) levels were examined during incline walking. MTU mechanical properties were assessed using simultaneously ultrasonography and dynamometry. Post exercise intervention, the elderly had higher TS and QF contractile strength and tendon-aponeurosis stiffness. Regarding the incline gait task, the subjects demonstrated a lower external knee adduction moment and lower knee adduction angular impulse during the stance phase post-intervention. Furthermore, post-intervention compared to pre-intervention, the elderly showed lower external hip adduction moment, but revealed higher plantarflexion pushoff moment. The changes in the external knee adduction moment were significantly correlated with the improvement in ankle pushoff function. Serum COMP concentration increased in response to the 0.5-h incline walking exercise with no differences in the magnitude of increment between pre- and post-intervention. This work emphasizes the important role played by the ankle pushoff function in knee joint mechanical loading during locomotion, and may justify the inclusion of the TS MTU in prevention programs aiming to positively influence specific mechanical markers for knee osteoarthritis in the elderly. However, the study was unable to show that COMP is amenable to change in the elderly following a 14-week exercise intervention and, therefore, the physiological benefit of improved muscle function for knee cartilage requires further investigation.

Collagen XII and XIV, new partners of cartilage oligomeric matrix protein in the skin extracellular matrix suprastructure.

PubMed

Agarwal, Pallavi; Zwolanek, Daniela; Keene, Douglas R; Schulz, Jan-Niklas; Blumbach, Katrin; Heinegård, Dick; Zaucke, Frank; Paulsson, Mats; Krieg, Thomas; Koch, Manuel; Eckes, Beate

2012-06-29

The tensile and scaffolding properties of skin rely on the complex extracellular matrix (ECM) that surrounds cells, vasculature, nerves, and adnexus structures and supports the epidermis. In the skin, collagen I fibrils are the major structural component of the dermal ECM, decorated by proteoglycans and by fibril-associated collagens with interrupted triple helices such as collagens XII and XIV. Here we show that the cartilage oligomeric matrix protein (COMP), an abundant component of cartilage ECM, is expressed in healthy human skin. COMP expression is detected in the dermal compartment of skin and in cultured fibroblasts, whereas epidermis and HaCaT cells are negative. In addition to binding collagen I, COMP binds to collagens XII and XIV via their C-terminal collagenous domains. All three proteins codistribute in a characteristic narrow zone in the superficial papillary dermis of healthy human skin. Ultrastructural analysis by immunogold labeling confirmed colocalization and further revealed the presence of COMP along with collagens XII and XIV in anchoring plaques. On the basis of these observations, we postulate that COMP functions as an adapter protein in human skin, similar to its function in cartilage ECM, by organizing collagen I fibrils into a suprastructure, mainly in the vicinity of anchoring plaques that stabilize the cohesion between the upper dermis and the basement membrane zone.

Proteomic Analysis of Tendon Extracellular Matrix Reveals Disease Stage-specific Fragmentation and Differential Cleavage of COMP (Cartilage Oligomeric Matrix Protein)*

PubMed Central

Dakin, Stephanie Georgina; Smith, Roger Kenneth Whealands; Heinegård, Dick; Önnerfjord, Patrik; Khabut, Areej; Dudhia, Jayesh

2014-01-01

During inflammatory processes the extracellular matrix (ECM) is extensively remodeled, and many of the constituent components are released as proteolytically cleaved fragments. These degradative processes are better documented for inflammatory joint diseases than tendinopathy even though the pathogenesis has many similarities. The aims of this study were to investigate the proteomic composition of injured tendons during early and late disease stages to identify disease-specific cleavage patterns of the ECM protein cartilage oligomeric matrix protein (COMP). In addition to characterizing fragments released in naturally occurring disease, we hypothesized that stimulation of tendon explants with proinflammatory mediators in vitro would induce fragments of COMP analogous to natural disease. Therefore, normal tendon explants were stimulated with IL-1β and prostaglandin E2, and their effects on the release of COMP and its cleavage patterns were characterized. Analyses of injured tendons identified an altered proteomic composition of the ECM at all stages post injury, showing protein fragments that were specific to disease stage. IL-1β enhanced the proteolytic cleavage and release of COMP from tendon explants, whereas PGE2 had no catabolic effect. Of the cleavage fragments identified in early stage tendon disease, two fragments were generated by an IL-1-mediated mechanism. These fragments provide a platform for the development of neo-epitope assays specific to injury stage for tendon disease. PMID:24398684

Collagen XII and XIV, New Partners of Cartilage Oligomeric Matrix Protein in the Skin Extracellular Matrix Suprastructure*

PubMed Central

Agarwal, Pallavi; Zwolanek, Daniela; Keene, Douglas R.; Schulz, Jan-Niklas; Blumbach, Katrin; Heinegård, Dick; Zaucke, Frank; Paulsson, Mats; Krieg, Thomas; Koch, Manuel; Eckes, Beate

2012-01-01

The tensile and scaffolding properties of skin rely on the complex extracellular matrix (ECM) that surrounds cells, vasculature, nerves, and adnexus structures and supports the epidermis. In the skin, collagen I fibrils are the major structural component of the dermal ECM, decorated by proteoglycans and by fibril-associated collagens with interrupted triple helices such as collagens XII and XIV. Here we show that the cartilage oligomeric matrix protein (COMP), an abundant component of cartilage ECM, is expressed in healthy human skin. COMP expression is detected in the dermal compartment of skin and in cultured fibroblasts, whereas epidermis and HaCaT cells are negative. In addition to binding collagen I, COMP binds to collagens XII and XIV via their C-terminal collagenous domains. All three proteins codistribute in a characteristic narrow zone in the superficial papillary dermis of healthy human skin. Ultrastructural analysis by immunogold labeling confirmed colocalization and further revealed the presence of COMP along with collagens XII and XIV in anchoring plaques. On the basis of these observations, we postulate that COMP functions as an adapter protein in human skin, similar to its function in cartilage ECM, by organizing collagen I fibrils into a suprastructure, mainly in the vicinity of anchoring plaques that stabilize the cohesion between the upper dermis and the basement membrane zone. PMID:22573329

Approaches for improving field soil identification

USDA-ARS?s Scientific Manuscript database

Use of soil survey information by non-soil scientists is often limited by their inability to 6 select the correct soil map unit component (COMP). Here, we developed two approaches that 7 can be deployed to smartphones for non-soil scientists to identify COMP using location alone, or 8 location toget...

A Comparison of Two Mathematics Problem-Solving Strategies: Facilitate Algebra-Readiness

ERIC Educational Resources Information Center

Xin, Yan Ping; Zhang, Dake; Park, Joo Young; Tom, Kinsey; Whipple, Amanda; Si, Luo

2011-01-01

The authors compared a conceptual model-based problem-solving (COMPS) approach with a general heuristic instructional approach for teaching multiplication-division word-problem solving to elementary students with learning problems (LP). The results indicate that only the COMPS group significantly improved, from pretests to posttests, their…

Teacher Mobility and Financial Incentives: A Descriptive Analysis of Denver's ProComp

ERIC Educational Resources Information Center

Fulbeck, Eleanor S.

2014-01-01

Extensive teacher mobility can undermine policy efforts to develop a high-quality workforce. In response, policymakers have increasingly championed financial incentives to retain teachers. In 2006, the Denver Public Schools adopted an alternative teacher compensation reform, the Professional Compensation System for Teachers ("ProComp").…

7 CFR 1780.75 - Contract provisions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... shall contain a provision requiring compliance with Executive Order 11246 (3 CFR, 1966 Comp., p.339), entitled, “Equal Employment Opportunity,” as amended by Executive Order 11375 (3 CFR, 1968 Comp., p. 321...) awarded by owners shall include a provision to the effect that the owner, the Agency, the Comptroller...

Public Access to Environmental Chemistry Data via the CompTox Chemistry Dashboard (ACS Fall Meeting 6 of 12)

EPA Science Inventory

The National Center for Computational Toxicology (NCCT) has assembled and delivered an enormous quantity and diversity of data for the environmental sciences through the CompTox Chemistry Dashboard. These data include high-throughput in vitro screening data, in vivo and functiona...

Risk Aversion and Support for Merit Pay: Theory and Evidence from Minnesota's Q Comp Program. Working Paper #09-05

ERIC Educational Resources Information Center

Nadler, Carl; Wiswall, Matthew

2009-01-01

Recent research attributes the lack of merit pay in teaching to the resistance of teachers. This paper examines whether the structure of merit pay affects the types of teachers who support it. We develop a model of the relative utility teachers receive from merit pay versus the current fixed schedule of raises. We show that if teachers are risk…

Complex sleep apnea unmasked by the use of a mandibular advancement device.

PubMed

Kuźniar, Tomasz J; Kovačević-Ristanović, Ružica; Freedom, Thomas

2011-05-01

According to most accepted definitions, complex sleep apnea syndrome (CompSAS) is described as an emergence of central apneas in a patient with obstructive sleep apnea (OSA) upon introduction of continuous positive airway pressure therapy (CPAP). We present two patients who developed comparable central apnea activity when treated with either a CPAP device or a mandibular advancement device. As similar findings have been previously documented in patients with OSA treated with maxillofacial surgery or tracheostomy, we propose that the current definition of CompSAS should broaden to include diagnosis of CompSAS in non-PAP-treated patients, who are managed with either a dental appliance or a surgical procedure.

An Application of Quality Control Theory to Vendor-Supplied Parts at an Aerospace Manufacturing Company.

DTIC Science & Technology

1985-08-01

presently used on the ATF3-6, TFE731 -2, -3, TPE331, GTCP660 and TSCP700 engines. Substantiation Metallurgical V Testing Tnstructions Control Part Name Part... TFE731 -2, -3 Fan 3072162 Ti-6-4 5001 C1.-2 L’$S52458 1st Stg.Comp. 3072193 Ti-6-4 5001 C1.-l AF5395 2nd Stg.Comp. 3072191 Ti-6-4 5001 CI.-I AF5395 W...Control Part Nam~e Part No. material (STIT~eouirernents Specification TFE731 -2, -3 4th Stg.Conp. 3072.93 Ti-6-4 5001 C1.-1 AF5395 HP Comp. 3072639 Ti-6-2

The US EPA CompTox Chemistry Dashboard as a source of data to fill data gaps for chemical sources of risk

EPA Science Inventory

Chemical risk assessment is both time-consuming and difficult because it requires the assembly of data for chemicals generally distributed across multiple sources. The US EPA CompTox Chemistry Dashboard is a publicly accessible web-based application providing access to various da...

34 CFR 85.315 - May I use the services of an excluded person as a principal under a covered transaction?

Code of Federal Regulations, 2010 CFR

2010-07-01

... this kind of an agreement or arrangement more than 90 days after you learn of the exclusion or after.... Authority: E.O. 12549 (3 CFR, 1986 Comp., p. 189); E.O 12689 (3 CFR, 1989 Comp., p. 235); 20 U.S.C. 1082...

Developing Consensus on the CompHP Professional Standards for Health Promotion in Europe

ERIC Educational Resources Information Center

Speller, Viv; Parish, Richard; Davison, Heather; Zilnyk, Anna

2012-01-01

Building on the CompHP Core Competencies for health promotion the Professional Standards for Health Promotion have been developed and consulted on across Europe. The standards were formulated to fit within the complexity of professional, occupational and educational standards frameworks in Europe as learning outcome standards with performance…

Numerical Modeling of Inverse Problems for Damage Detection in Aircraft Structures

DTIC Science & Technology

2009-12-16

e de fadiga em reparos de materiais compósitos em chapas trincadas. X Encontro de Modelagem Computacional, Nova Friburgo. 11. Santos, RR, Sollero...P, Useche, J, Albuquerque, EL (2007). Análise estática de chapas trincadas com reparo de material compósito. X Encontro de Modelagem Computacional

24 CFR 882.803 - Project eligibility and other requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... receiving Federal funding for rental assistance or operating costs under other HUD programs. (3) Nursing... providing continual psychiatric, medical, or nursing services are not eligible for assistance under this.... 3601-19), E.O. 11063 (as amended by E.O. 12259; 3 CFR, 1959-1963 Comp., p. 652 and 3 CFR, 1980 Comp., p...

24 CFR 882.803 - Project eligibility and other requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... receiving Federal funding for rental assistance or operating costs under other HUD programs. (3) Nursing... providing continual psychiatric, medical, or nursing services are not eligible for assistance under this.... 3601-19), E.O. 11063 (as amended by E.O. 12259; 3 CFR, 1959-1963 Comp., p. 652 and 3 CFR, 1980 Comp., p...

24 CFR 882.803 - Project eligibility and other requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... receiving Federal funding for rental assistance or operating costs under other HUD programs. (3) Nursing... providing continual psychiatric, medical, or nursing services are not eligible for assistance under this.... 3601-19), E.O. 11063 (as amended by E.O. 12259; 3 CFR, 1959-1963 Comp., p. 652 and 3 CFR, 1980 Comp., p...

24 CFR 882.803 - Project eligibility and other requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... receiving Federal funding for rental assistance or operating costs under other HUD programs. (3) Nursing... providing continual psychiatric, medical, or nursing services are not eligible for assistance under this.... 3601-19), E.O. 11063 (as amended by E.O. 12259; 3 CFR, 1959-1963 Comp., p. 652 and 3 CFR, 1980 Comp., p...

75 FR 11988 - Aviation Proceedings, Agreements Filed the Week Ending February 27, 2010

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-12

... Air Transport Association. Subject: Mail Vote 625--Resolution 010p, TC3 Japan, Korea-South East Asia...: Members of the International Air Transport Association. Subject: PTC COMP Mail Vote 620, Resolution 024d... International Air Transport Association. Subject: PTC COMP Mail Vote 626, Resolution 011a, Mileage Manual Non TC...

Real-time prediction of Physicochemical and Toxicological Endpoints Using the Web-based CompTox Chemistry Dashboard (ACS Fall meeting) 10 of 12

EPA Science Inventory

The EPA CompTox Chemistry Dashboard developed by the National Center for Computational Toxicology (NCCT) provides access to data for ~750,000 chemical substances. The data include experimental and predicted data for physicochemical, environmental fate and transport and toxicologi...

34 CFR 85.315 - May I use the services of an excluded person as a principal under a covered transaction?

Code of Federal Regulations, 2011 CFR

2011-07-01

... this kind of an agreement or arrangement more than 90 days after you learn of the exclusion or after.... (Authority: E.O. 12549 (3 CFR, 1986 Comp., p. 189); E.O 12689 (3 CFR, 1989 Comp., p. 235); 20 U.S.C. 1082...

Developing a Competency-Based Pan-European Accreditation Framework for Health Promotion

ERIC Educational Resources Information Center

Battel-Kirk, Barbara; Van der Zanden, Gerard; Schipperen, Marielle; Contu, Paolo; Gallardo, Carmen; Martinez, Ana; Garcia de Sola, Silvia; Sotgiu, Alessandra; Zaagsma, Miriam; Barry, Margaret M.

2012-01-01

Background: The CompHP Pan-European Accreditation Framework for Health Promotion was developed as part of the CompHP Project that aimed to develop competency-based standards and an accreditation system for health promotion practice, education, and training in Europe. Method: A phased, multiple-method approach was employed to facilitate consensus…

Experimental demonstration of fronthaul flexibility for enhanced CoMP service in 5G radio and optical access networks.

PubMed

Zhang, Jiawei; Ji, Yuefeng; Yu, Hao; Huang, Xingang; Li, Han

2017-09-04

The RAN architecture towards mobile 5G and beyond is undergoing a fundamental evolution, which brings optics into the radio world. Fronthaul is a new segment that leverages on the advantages of optical communication for RAN transport. However, the current fronthaul architecture shows a fixed connection between an RRH and a BBU, which leads to inefficient resource utilization. In this paper, we focus on the fronthaul flexibility that allows "any-RRH to any-BBU" connection. In particular, we consider a CoMP service and discuss how flexible optical fronthaul helps to improve its performance. To achieve this goal, we propose an SDN-enabled orchestration for coordinating radio and optical access networks. Under this unified control manner, the agile RRH-BBU mapping can be reached through lightpath reconfiguration. To further verify the benefits of flexibility, we experiment the CoMP service in the cloud radio over flexible optical fronthaul (CRoFlex) testbed. Experimental results demonstrate the proposed SDN-enabled flexible optical fronthaul can improve the CoMP performance by optimizing the RRH-BBU mapping.

Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis.

PubMed

Liu, Chuan-ju; Prazak, Lisa; Fajardo, Marc; Yu, Shuang; Tyagi, Neetu; Di Cesare, Paul E

2004-11-05

Mutations in the human cartilage oligomeric matrix protein (COMP) gene have been linked to the development of pseudoachondroplasia and multiple epiphyseal dysplasia. We previously cloned the promoter region of the COMP gene and delineated a minimal negative regulatory element (NRE) that is both necessary and sufficient to repress its promoter (Issack, P. S., Fang, C. H., Leslie, M. P., and Di Cesare, P. E. (2000) J. Orthop. Res. 18, 345-350; Issack, P. S., Liu, C. J., Prazak, L., and Di Cesare, P. E. (2004) J. Orthop. Res. 22, 751-758). In this study, a yeast one-hybrid screen for proteins that associate with the NRE led to the identification of the leukemia/lymphoma-related factor (LRF), a transcriptional repressor that contains a POZ (poxvirus zinc finger) domain, as an NRE-binding protein. LRF bound directly to the NRE both in vitro and in living cells. Nine nucleotides (GAGGGTCCC) in the 30-bp NRE are essential for binding to LRF. LRF showed dose-dependent inhibition of COMP-specific reporter gene activity, and exogenous overexpression of LRF repressed COMP gene expression in both rat chondrosarcoma cells and bone morphogenetic protein-2-treated C3H10T1/2 progenitor cells. In addition, LRF also inhibited bone morphogenetic protein-2-induced chondrogenesis in high density micromass cultures of C3H10T1/2 cells, as evidenced by lack of expression of other chondrocytic markers, such as aggrecan and collagen types II, IX, X, and XI, and by Alcian blue staining. LRF associated with histone deacetylase-1 (HDAC1), and experiments utilizing the HDAC inhibitor trichostatin A revealed that LRF-mediated repression requires deacetylase activity. LRF is the first transcription factor found to bind directly to the COMP gene promoter, to recruit HDAC1, and to regulate both COMP gene expression and chondrogenic differentiation.

Running decreases knee intra-articular cytokine and cartilage oligomeric matrix concentrations: a pilot study.

PubMed

Hyldahl, Robert D; Evans, Alyssa; Kwon, Sunku; Ridge, Sarah T; Robinson, Eric; Hopkins, J Ty; Seeley, Matthew K

2016-12-01

Regular exercise protects against degenerative joint disorders, yet the mechanisms that underlie these benefits are poorly understood. Chronic, low-grade inflammation is widely implicated in the onset and progression of degenerative joint disease. To examine the effect of running on knee intra-articular and circulating markers of inflammation and cartilage turnover in healthy men and women. Six recreational runners completed a running (30 min) and control (unloaded for 30 min) session in a counterbalanced order. Synovial fluid (SF) and serum samples were taken before and after each session. Cytokine concentration was measured in SF and serum using a multiplexed cytokine magnetic bead array. Ground reaction forces were measured during the run. There were no changes in serum or SF cytokine concentration in the control condition. The cytokine GM-CSF decreased from 10.7 ± 9.8 to 6.2 ± 5.9 pg/ml pre- to post-run (p = 0.03). IL-15 showed a trend for decreasing concentration pre- (6.7 ± 7.5 pg/ml) to post-run (4.3 ± 2.7 pg/ml) (p = 0.06). Changes in IL-15 concentration negatively correlated with the mean number of foot strikes during the run (r 2  = 0.67; p = 0.047). The control condition induced a decrease in serum COMP and an increase in SF COMP, while conversely the run induced an increase in serum COMP and a decrease in SF COMP. Changes in serum and SF COMP pre- to post-intervention were inversely correlated (r 2  = 0.47; p = 0.01). Running appears to decrease knee intra-articular pro-inflammatory cytokine concentration and facilitates the movement of COMP from the joint space to the serum.

Programming Environments for High Level Scientific Problem Solving. IFIP WG 2.5 Working Conference 6 Held in Karlsruhe, Germany on September 23 - 27, 1991

DTIC Science & Technology

1991-09-27

Springer Verlag (1989). (13] Hulshof , B.J.A. and van Hulzen, J.A.: "Automatic error cumulation control", Proceedir EUROSAM 󈨘 (J. Fitch. ed.), Springer...User’s Manual", Dept of Comp. Science. Univ. of Twente (In preparation). 268 [15] van Hulzen, J.A., Hulshof , B.J.A.. Gates, B.L. and van Heerwaarden, M.C

Automation and Mankind

DTIC Science & Technology

1960-08-07

limited by the cap- abilities of the human organism in the matter of control of its processes. In our time, the speeds of technological processes are...in many cases limited by conditions of control. The speed of human reaction is limited and therefore, at pre- sent, only processes of a relatively...forwiard, It can e foreseer thast automIation will comp~letely free Mans -Pn work unler conlitions’ of high texpemratures pressures,, anid nollutA-: or

Structure Identification Using High Resolution Mass Spectrometry Data and the EPA’s CompTox Chemistry Dashboard (EAS)

EPA Science Inventory

The iCSS CompTox Dashboard is a publicly accessible dashboard provided by the National Center for Computation Toxicology at the US-EPA. It serves a number of purposes, including providing a chemistry database underpinning many of our public-facing projects (e.g. ToxCast and ExpoC...

The EPA CompTox Dashboard and Underpinning Software Architecture – a platform for data integration for environmental chemistry data (ACS Fall Meeting 7 of 12)

EPA Science Inventory

The CompTox Dashboard was developed by the Environmental Protection Agency’s National Center for Computational Toxicology. This dashboard has been architected in a manner that allows for the deployment of multiple “applications”, both as publicly available databases, and for dep...

Estimated Student Score Gain on the ACT COMP Exam: Valid Tool for Institutional Assessment?

ERIC Educational Resources Information Center

Banta, Trudy W.; And Others

1987-01-01

An institution can test seniors with the ACT College Outcome Measures Project (COMP) exam, then subtract from the senior score an estimated freshman score. Studies at the University of Tennessee, Knoxville, indicate that this method is not reliable to make judgments about the quality of general education programs. (Author/MLW)

78 FR 36098 - Final Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-17

... of 1978, 3 CFR, 1978 Comp., p. 329; E.O. 12127, 44 FR 19367, 3 CFR, 1979 Comp., p. 376. Sec. 67.11... Areas Docket No.: FEMA-B-1216 Mississippi River Approximately 1.67 miles +38 City of Plaquemine, Town upstream of the White of White Castle. Castle-Carville Ferry. Approximately 2 miles +38 upstream of the...

75 FR 5349 - Investigations Regarding Certifications of Eligibility To Apply for Worker Adjustment Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-02

... Products, LLC (Comp). Walterboro, SC........ 12/16/09 12/09/09 73110 Robin Industries, Inc. Cleveland, OH... Garland Commercial Freeland, PA 12/18/09 12/17/09 Industries, LLC (Comp). 73124 Suite Simplicity, LLC.../09 73126 Frescale Semiconductor, Austin, TX 12/18/09 12/11/09 Inc. (Wkrs). 73127 Freescale...

On-line process analysis innovation: DiComp (tm) shunting dielectric sensor technology

NASA Technical Reports Server (NTRS)

Davis, Craig R.; Waldman, Frank A.

1993-01-01

The DiComp Shunting Dielectric Sensor (SDS) is a new patent-pending technology developed under the Small Business Innovation Research Program (SBIR) for NASA's Kennedy Space Center. The incorporation of a shunt electrode into a conventional fringing field dielectric sensor makes the SDS uniquely sensitive to changes in material dielectric properties in the KHz to MHz range which were previously detectable only at GHz measurement frequencies. The initial NASA application of the SDS for Nutrient Delivery Control has demonstrated SDS capabilities for thickness and concentration measurement of Hoagland nutrient solutions. The commercial introduction of DiComp SDS technology for concentration and percent solids measurements in dispersions, emulsions and solutions represents a new technology for process measurements for liquids in a variety of industries.

The semantics of Chemical Markup Language (CML) for computational chemistry : CompChem.

PubMed

Phadungsukanan, Weerapong; Kraft, Markus; Townsend, Joe A; Murray-Rust, Peter

2012-08-07

: This paper introduces a subdomain chemistry format for storing computational chemistry data called CompChem. It has been developed based on the design, concepts and methodologies of Chemical Markup Language (CML) by adding computational chemistry semantics on top of the CML Schema. The format allows a wide range of ab initio quantum chemistry calculations of individual molecules to be stored. These calculations include, for example, single point energy calculation, molecular geometry optimization, and vibrational frequency analysis. The paper also describes the supporting infrastructure, such as processing software, dictionaries, validation tools and database repositories. In addition, some of the challenges and difficulties in developing common computational chemistry dictionaries are discussed. The uses of CompChem are illustrated by two practical applications.

The semantics of Chemical Markup Language (CML) for computational chemistry : CompChem

PubMed Central

2012-01-01

This paper introduces a subdomain chemistry format for storing computational chemistry data called CompChem. It has been developed based on the design, concepts and methodologies of Chemical Markup Language (CML) by adding computational chemistry semantics on top of the CML Schema. The format allows a wide range of ab initio quantum chemistry calculations of individual molecules to be stored. These calculations include, for example, single point energy calculation, molecular geometry optimization, and vibrational frequency analysis. The paper also describes the supporting infrastructure, such as processing software, dictionaries, validation tools and database repositories. In addition, some of the challenges and difficulties in developing common computational chemistry dictionaries are discussed. The uses of CompChem are illustrated by two practical applications. PMID:22870956

Relationship of multiscale entropy to task difficulty and sway velocity in healthy young adults.

PubMed

Lubetzky, Anat V; Price, Robert; Ciol, Marcia A; Kelly, Valerie E; McCoy, Sarah W

2015-01-01

Multiscale entropy (MSE) is a nonlinear measure of postural control that quantifies how complex the postural sway is by assigning a complexity index to the center of pressure (COP) oscillations. While complexity has been shown to be task dependent, the relationship between sway complexity and level of task challenge is currently unclear. This study tested whether MSE can detect short-term changes in postural control in response to increased standing balance task difficulty in healthy young adults and compared this response to that of a traditional measure of postural steadiness, root mean square of velocity (VRMS). COP data from 20 s of quiet stance were analyzed when 30 healthy young adults stood on the following surfaces: on floor and foam with eyes open and closed and on the compliant side of a Both Sides Up (BOSU) ball with eyes open. Complexity index (CompI) was derived from MSE curves. Repeated measures analysis of variance across standing conditions showed a statistically significant effect of condition (p < 0.001) in both the anterior-posterior and medio-lateral directions for both CompI and VRMS. In the medio-lateral direction there was a gradual increase in CompI and VRMS with increased standing challenge. In the anterior-posterior direction, VRMS showed a gradual increase whereas CompI showed significant differences between the BOSU and all other conditions. CompI was moderately and significantly correlated with VRMS. Both nonlinear and traditional measures of postural control were sensitive to the task and increased with increasing difficulty of standing balance tasks in healthy young adults.

Moxifloxacin in Pediatric Patients with Complicated Intra-Abdominal Infections: Results of the MOXIPEDIA Randomized Controlled Study.

PubMed

Wirth, Stefan; Emil, Sherif G S; Engelis, Arnis; Digtyar, Valeri; Criollo, Margarita; DiCasoli, Carl; Stass, Heino; Willmann, Stefan; Nkulikiyinka, Richard; Grossmann, Ulrike

2018-01-18

This study was designed to evaluate primarily the safety and also the efficacy of moxifloxacin (MXF) in children with complicated intra-abdominal infections (cIAIs). In this multicenter, randomized, double-blind, controlled study, 451 pediatric patients aged 3 months to 17 years with cIAIs were treated with intravenous/oral MXF (N = 301) or comparator (COMP, intravenous ertapenem followed by oral amoxicillin/clavulanate; N = 150) for 5 to 14 days. Doses of MXF were selected based on the results of a Phase 1 study in pediatric patients (NCT01049022). The primary endpoint was safety, with particular focus on cardiac and musculoskeletal safety; clinical and bacteriological efficacy at test of cure were also investigated. The proportion of patients with adverse events (AEs) was comparable between the two treatment arms (MXF: 58.1% and COMP: 54.7%). The incidence of drug-related AEs was higher in the MXF arm than the COMP arm (14.3% and 6.7%, respectively). No cases of QTc interval prolongation-related morbidity or mortality were observed. The proportion of patients with musculoskeletal AEs was comparable between treatment arms; no drug-related events were reported. Clinical cure rates were 84.6% and 95.5% in the MXF and COMP arms, respectively, in patients with confirmed pathogen(s) at baseline. MXF treatment was well tolerated in children with cIAIs. However, a lower clinical cure rate was observed with MXF treatment compared with COMP. This study does not support a recommendation of MXF for children with cIAIs when alternative more efficacious antibiotics with better safety profile are available.

The Influence of Preprocessing Steps on Graph Theory Measures Derived from Resting State fMRI

PubMed Central

Gargouri, Fatma; Kallel, Fathi; Delphine, Sebastien; Ben Hamida, Ahmed; Lehéricy, Stéphane; Valabregue, Romain

2018-01-01

Resting state functional MRI (rs-fMRI) is an imaging technique that allows the spontaneous activity of the brain to be measured. Measures of functional connectivity highly depend on the quality of the BOLD signal data processing. In this study, our aim was to study the influence of preprocessing steps and their order of application on small-world topology and their efficiency in resting state fMRI data analysis using graph theory. We applied the most standard preprocessing steps: slice-timing, realign, smoothing, filtering, and the tCompCor method. In particular, we were interested in how preprocessing can retain the small-world economic properties and how to maximize the local and global efficiency of a network while minimizing the cost. Tests that we conducted in 54 healthy subjects showed that the choice and ordering of preprocessing steps impacted the graph measures. We found that the csr (where we applied realignment, smoothing, and tCompCor as a final step) and the scr (where we applied realignment, tCompCor and smoothing as a final step) strategies had the highest mean values of global efficiency (eg). Furthermore, we found that the fscr strategy (where we applied realignment, tCompCor, smoothing, and filtering as a final step), had the highest mean local efficiency (el) values. These results confirm that the graph theory measures of functional connectivity depend on the ordering of the processing steps, with the best results being obtained using smoothing and tCompCor as the final steps for global efficiency with additional filtering for local efficiency. PMID:29497372

The Influence of Preprocessing Steps on Graph Theory Measures Derived from Resting State fMRI.

PubMed

Gargouri, Fatma; Kallel, Fathi; Delphine, Sebastien; Ben Hamida, Ahmed; Lehéricy, Stéphane; Valabregue, Romain

2018-01-01

Resting state functional MRI (rs-fMRI) is an imaging technique that allows the spontaneous activity of the brain to be measured. Measures of functional connectivity highly depend on the quality of the BOLD signal data processing. In this study, our aim was to study the influence of preprocessing steps and their order of application on small-world topology and their efficiency in resting state fMRI data analysis using graph theory. We applied the most standard preprocessing steps: slice-timing, realign, smoothing, filtering, and the tCompCor method. In particular, we were interested in how preprocessing can retain the small-world economic properties and how to maximize the local and global efficiency of a network while minimizing the cost. Tests that we conducted in 54 healthy subjects showed that the choice and ordering of preprocessing steps impacted the graph measures. We found that the csr (where we applied realignment, smoothing, and tCompCor as a final step) and the scr (where we applied realignment, tCompCor and smoothing as a final step) strategies had the highest mean values of global efficiency (eg) . Furthermore, we found that the fscr strategy (where we applied realignment, tCompCor, smoothing, and filtering as a final step), had the highest mean local efficiency (el) values. These results confirm that the graph theory measures of functional connectivity depend on the ordering of the processing steps, with the best results being obtained using smoothing and tCompCor as the final steps for global efficiency with additional filtering for local efficiency.

Predictive parameters for selection of electronic tissue compensation radiotherapy in early-stage breast cancer patients after breast-conserving surgery.

PubMed

Song, Yanbo; Zhang, Miao; Gan, Lu; Chen, Xiaopin; Zhang, Tao; Yue, Ning J; Goyal, Sharad; Haffty, Bruce; Ren, Guosheng

2016-05-31

Electronic tissue compensation (eComp) is an external beam planning technique allowing user to manually generate dynamic beam fluence to produce more uniform or modulated dose distribution. In this study, we compared the effectiveness between conventional three-dimensional conformal radiotherapy (3DCRT) and eComp for whole breast irradiation. 3DCRT and eComp planning techniques were used to generate treatment plans for 60 whole breast patients, respectively. The planning goal was to cover 95% of the planning target volume (PTV) with 95% of the prescription dose while minimizing doses to lung, heart, and skin. Comparing to 3DCRT plans, on the average, eComp treatment planning process was about 7 minutes longer, but resulted in lower lung V20Gy, lower mean skin dose, with similar heart dose. The benefits were more pronounced for larger breast patients. Statistical analyses were performed between critical organ doses and patient anatomic features, i.e., central lung distance (CLD), maximal heart distance (MHD), maximal heart length (MHL) and breast separation (BS) to explore any correlations and planning method selection. It was found that to keep the lung V20Gy lower than 20% and mean skin dose lower than 85% of the prescription dose, eComp was the preferred method for patients with more than 2.3 cm CLD or larger than 22.5 cm BS. The study results may be useful in providing a handy criterion in clinical practice allowing us to easily choose between different planning techniques to satisfy the planning goal with minimal increase in complexity and cost.

Using the US EPA's CompTox Dashboard to support identification and screening of emerging organic contaminants in the environment (ACS Spring National meeting) 2 of 7

EPA Science Inventory

The US EPA’s iCSS CompTox Dashboard is a curated, publicly accessible resource provided by the National Center for Computational Toxicology (https://comptox.epa.gov). The Dashboard provides support for toxicology and risk assessment within and external to the EPA (including ToxC...

Transforming Research and Clinical Knowledge in Traumatic Brain Injury

DTIC Science & Technology

2014-10-01

HEMATOPOETIC Coagulopathy DIC Anemia Requiring Treatment Other Other PULMONARY ARDS Fat Embolus Pulmonary Embolism Pleural Effusions Pneumonia...ComplAsthma, ComplOtherPulmonary1, CompOtherCardio1Txt, ComplOtherPulmonary2, CompOtherCardio2Txt CRF Field ARDS, Fat Embolus, Pulmonary Embolism ...Description Complications Pulmonary: ARDS, Fat Embolus, Pulmonary Embolism , Pleural Effusions, Pneumonia, Presumed Pneumonia, Respiratory Failure

Mass-Spectrometry Based Structure Identification of "Known-Unknowns" Using the EPA's CompTox Dashboard (ACS Spring National Meeting) 4 of 7

EPA Science Inventory

The CompTox Dashboard is a publicly accessible database provided by the National Center for Computational Toxicology at the US-EPA. The dashboard provides access to a database containing ~720,000 chemicals and integrates a number of our public-facing projects (e.g. ToxCast and Ex...

Response of loblolly pine to complete woody and herbaceous control: projected yields and economic outcomes - the COMProject

Treesearch

James H. Miller; R.L. Busby; B.R. Zutter; S.M. Zedaker; M.B. Edwards; R.A. Newbold

1995-01-01

Abstract.Age-8 and -9 data from the 13 study plantations of the Competition Omission Monitoring Project (COMP) were used to project yields and derive economic outcomes for loblolly pine (Pinus taeda L.). COMP treatments were chop-burn, complete woody plant control, complete herbaceous plant control for 4 years, and complete woody...

Using semi-automated curation workflows to collect, organize, and curate the data and models necessary to support the EPA CompTox chemical dashboard (ACS Spring meeting)

EPA Science Inventory

With the increasing need to leverage data and models to perform cutting edge analyses within the environmental science community, collection and organization of that data into a readily accessible format for consumption is a pressing need. The EPA CompTox chemical dashboard is i...

75 FR 5149 - Employment and Training Administration Investigations Regarding Certifications of Eligibility To...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-01

...). 73109 Dayco Products, LLC (Comp). Walterboro, SC........ 12/16/09 12/09/09 73110 Robin Industries, Inc.../17/09 73123 Garland Commercial Freeland, PA 12/18/09 12/17/09 Industries, LLC (Comp). 73124 Suite..., TX 12/18/09 12/16/09 73126 Freescale Semiconductor, Austin, TX 12/18/09 12/11/09 Inc. (Wkrs). 73127...

Designed angiopoietin-1 variant, COMP-angiopoietin-1, rescues erectile function through healthy cavernous angiogenesis in a hypercholesterolemic mouse

PubMed Central

Ryu, Ji-Kan; Kim, Woo Jean; Koh, Young Jun; Piao, Shuguang; Jin, Hai-Rong; Lee, Sae-Won; Choi, Min Ji; Shin, Hwa-Yean; Kwon, Mi-Hye; Jung, Keehoon; Koh, Gou Young; Suh, Jun-Kyu

2015-01-01

Despite the advent of oral phosphodiesterase-5 inhibitors, curative treatment for erectile dysfunction (ED) remains unavailable. Recently, the link between ED and cardiovascular disease was unveiled and the main etiology of ED was found to be vasculogenic. Therefore, neovascularization is a promising strategy for curing ED. Angiopoietin-1 (Ang1) is an angiogenic growth factor that promotes the generation of stable and functional vasculature. Here, we demonstrate that local delivery of the soluble, stable, and potent Ang1 variant, COMP-Ang1 gene or protein, into the penises of hypercholesterolemic mice increases cavernous angiogenesis, eNOS phosphorylation, and cGMP expression, resulting in full recovery of erectile function and cavernous blood flow up to 8 weeks after treatment. COMP-Ang1-induced promotion of cavernous angiogenesis and erectile function was abolished in Nos3-/- mice and in the presence of the NOS inhibitor, L-NAME. COMP-Ang1 also restored the integrity of endothelial cell-cell junction by down-regulating the expression of histone deacetylase 2 in the penis of hypercholesterolemic mice and in primary cultured mouse cavernous endothelial cells. These findings constitute a new paradigm toward curative treatment of both cavernous angiopathy and ED. PMID:25783805

Yield Stress Model for Molten Composition B-3

NASA Astrophysics Data System (ADS)

Davis, Stephen; Zerkle, David

2017-06-01

Composition B-3 (Comp B-3) is a melt-castable explosive composed of 60/40 wt% RDX/TNT (hexahydro-1,3,5-trinitro-1,3,5-triazine/2,4,6-trinitrotoluene). During casting operations thermal conditions are controlled which along with the low melting point of TNT and the insensitivity of the mixture to external stimuli leading to safe use. Outside these standard operating conditions a more rigorous model of Comp B-3 rheological properties is necessary to model thermal transport as Comp B-3 evolves from quiescent solid through vaporization/decomposition upon heating. One particular rheological phenomena of interest is Bingham plasticity, where a material behaves as a quiescent solid unless a sufficient load is applied, resulting in fluid flow. In this study falling ball viscometer data is used to model the change in Bingham plastic yield stresses as a function of RDX particle volume fraction; a function of temperature. Results show the yield stress of Comp B-3 (τy) follows the expression τy = B ϕ -ϕc N , where Φ and Φc are the volume fraction of RDX and a critical volume fraction, respectively and B and N are experimentally evaluated constants.

Sleep, anxiety and electronic device use by athletes in the training and competition environments.

PubMed

Romyn, Georgia; Robey, Elisa; Dimmock, James A; Halson, Shona L; Peeling, Peter

2016-01-01

This study subjectively assessed sleep quality and quantity, state anxiety and electronic device use during a 7-day training week (TRAIN) and a 7-day competitive tournament (COMP). Eight state-level netball players used wrist-watch actigraphy to provide indirect sleep measures of bedtime, wake time, sleep duration, sleep onset latency, sleep efficiency, wake after sleep onset and fragmentation index. State anxiety was reported using the anxiety sub-scale in the Profile of Mood States-Adolescents. Before bed duration of electronic device use and the estimated time to sleep after finishing electronic device use was also recorded. Significant main effects showed that sleep efficiency (p = 0.03) was greater in COMP as compared to TRAIN. Furthermore, the bedtime and wake time were earlier (p = 0.01) during COMP. No further differences existed between conditions (p > 0.05). However, strong negative associations were seen between state anxiety and the sleep quality rating. Here, sleep efficiency was likely greater in COMP due to the homeostatic need for recovery sleep, resulting from the change in environment from training to competition. Furthermore, an increased anxiety before bed seems to influence sleep quality and should be considered in athletes portraying poor sleep habits.

Comparative analysis of the scope of European Union paediatric investigation plans with corresponding orphan designations.

PubMed

Ecker, Andrea; Mariz, Segundo; Naumann-Winter, Frauke; Norga, Koenraad; Barisic, Ingeborg; Girard, Thomas; Tomasi, Paolo; Mentzer, Dirk; Sepodes, Bruno

2018-05-01

Market forces may not be sufficient to stimulate research and development of medicines for small patient populations, such as children and patients with rare diseases. Both the European Union Orphan and Paediatric Regulations were introduced to address the unmet public health needs of these smaller patient populations through the use of incentives, rewards and obligations. Developers for new medicines for rare diseases must agree a paediatric investigation plan (PIP) or waiver with the European Medicines Agency's (EMA) Paediatric Committee (PDCO), and can also apply for an orphan designation (OD) from the EMA's Committee of Orphan Medicinal Products (COMP). The scope of both the OD and the PIP (or waiver) is defined by the agreed condition. The aim of this study was to analyse the approach of PDCO and COMP in defining the appropriate condition for a PIP or OD, respectively, in order to investigate potential challenges in the paediatric development of orphan medicines which have to meet the requirements of both legislations. A comparative analysis of PIP conditions and OD conditions was performed for medicines that have been reviewed by both Committees. We found that in the substantial majority of cases there is no divergence between the conclusions of COMP and PDCO with regard to the condition for which a medicine is to be developed. These findings demonstrate that a collaborative approach allows both Regulations to work synergistically to foster pharmaceutical development for rare diseases in childhood. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

An Information Framework for Facility Operators

DTIC Science & Technology

1991-01-01

and replacement products. Type: Type is used to decompose the building into smaller categories called arrangements, assemblies, parts, joints , and forro...are organized into crews and shops consisting of tradepersons responsible for building materials (concrete, masonry, metals, drywall , paint, etc...Comp Type (pre-cast, CIP) AS I Curing compound , sealant tyDe A S 04--- Masonry Comp Type (CMU, stone, glazed) A S I Manufacturer, style no., color no

34 CFR 85.625 - What is the scope of a suspension or debarment?

Code of Federal Regulations, 2010 CFR

2010-07-01

... individuals, divisions, or other organizational elements; or (2) To specific types of transactions. (b) Any... opportunity to contest the action. Authority: E.O. 12549 (3 CFR, 1986 Comp., p. 189); E.O 12689 (3 CFR, 1989 Comp., p. 235); 20 U.S.C. 1082, 1094, 1221e-3 and 3474; and Sec. 2455, Pub. L. 103-355, 108 Stat. 3243...

34 CFR 85.25 - How is this part organized?

Code of Federal Regulations, 2010 CFR

2010-07-01

... information about this rule. B the types of ED transactions that are covered by the Governmentwide... transaction A, B, D, E and I. (7) Reserved J. Authority: E.O. 12549 (3 CFR, 1986 Comp., p. 189); E.O 12689 (3 CFR, 1989 Comp., p. 235); 20 U.S.C. 1082, 1094, 1221e-3 and 3474; and Sec. 2455, Pub. L. 103-355, 108...

Concordance and predictive value of two adverse drug event data sets.

PubMed

Cami, Aurel; Reis, Ben Y

2014-08-22

Accurate prediction of adverse drug events (ADEs) is an important means of controlling and reducing drug-related morbidity and mortality. Since no single "gold standard" ADE data set exists, a range of different drug safety data sets are currently used for developing ADE prediction models. There is a critical need to assess the degree of concordance between these various ADE data sets and to validate ADE prediction models against multiple reference standards. We systematically evaluated the concordance of two widely used ADE data sets - Lexi-comp from 2010 and SIDER from 2012. The strength of the association between ADE (drug) counts in Lexi-comp and SIDER was assessed using Spearman rank correlation, while the differences between the two data sets were characterized in terms of drug categories, ADE categories and ADE frequencies. We also performed a comparative validation of the Predictive Pharmacosafety Networks (PPN) model using both ADE data sets. The predictive power of PPN using each of the two validation sets was assessed using the area under Receiver Operating Characteristic curve (AUROC). The correlations between the counts of ADEs and drugs in the two data sets were 0.84 (95% CI: 0.82-0.86) and 0.92 (95% CI: 0.91-0.93), respectively. Relative to an earlier snapshot of Lexi-comp from 2005, Lexi-comp 2010 and SIDER 2012 introduced a mean of 1,973 and 4,810 new drug-ADE associations per year, respectively. The difference between these two data sets was most pronounced for Nervous System and Anti-infective drugs, Gastrointestinal and Nervous System ADEs, and postmarketing ADEs. A minor difference of 1.1% was found in the AUROC of PPN when SIDER 2012 was used for validation instead of Lexi-comp 2010. In conclusion, the ADE and drug counts in Lexi-comp and SIDER data sets were highly correlated and the choice of validation set did not greatly affect the overall prediction performance of PPN. Our results also suggest that it is important to be aware of the differences that exist among ADE data sets, especially in modeling applications focused on specific drug and ADE categories.

iDoComp: a compression scheme for assembled genomes

PubMed Central

Ochoa, Idoia; Hernaez, Mikel; Weissman, Tsachy

2015-01-01

Motivation: With the release of the latest next-generation sequencing (NGS) machine, the HiSeq X by Illumina, the cost of sequencing a Human has dropped to a mere $4000. Thus we are approaching a milestone in the sequencing history, known as the $1000 genome era, where the sequencing of individuals is affordable, opening the doors to effective personalized medicine. Massive generation of genomic data, including assembled genomes, is expected in the following years. There is crucial need for compression of genomes guaranteed of performing well simultaneously on different species, from simple bacteria to humans, which will ease their transmission, dissemination and analysis. Further, most of the new genomes to be compressed will correspond to individuals of a species from which a reference already exists on the database. Thus, it is natural to propose compression schemes that assume and exploit the availability of such references. Results: We propose iDoComp, a compressor of assembled genomes presented in FASTA format that compresses an individual genome using a reference genome for both the compression and the decompression. In terms of compression efficiency, iDoComp outperforms previously proposed algorithms in most of the studied cases, with comparable or better running time. For example, we observe compression gains of up to 60% in several cases, including H.sapiens data, when comparing with the best compression performance among the previously proposed algorithms. Availability: iDoComp is written in C and can be downloaded from: http://www.stanford.edu/~iochoa/iDoComp.html (We also provide a full explanation on how to run the program and an example with all the necessary files to run it.). Contact: iochoa@stanford.edu Supplementary information: Supplementary Data are available at Bioinformatics online. PMID:25344501

Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing.

PubMed

Taylor, Adam M; Hsueh, Ming-Feng; Ranganath, Lakshminarayan R; Gallagher, James A; Dillon, Jane P; Huebner, Janet L; Catterall, Jon B; Kraus, Virginia B

2017-01-01

Alkaptonuria (AKU) is a rare autosomal recessive disease resulting from a single enzyme deficiency in tyrosine metabolism. As a result, homogentisic acid cannot be metabolized, causing systemic increases. Over time, homogentisic acid polymerizes and deposits in collagenous tissues, leading to ochronosis. Typically, this occurs in joint cartilages, leading to an early onset, rapidly progressing osteoarthropathy. The aim of this study was to examine tissue turnover in cartilage affected by ochronosis and its role in disease initiation and progression. With informed patient consent, hip and knee cartilages were obtained at surgery for arthropathy due to AKU (n = 6; 2 knees/4 hips) and OA (n = 12; 5 knees/7 hips); healthy non-arthritic (non-OA n = 6; 1 knee/5 hips) cartilages were obtained as waste from trauma surgery. We measured cartilage concentrations (normalized to dry weight) of racemized aspartate, GAG, COMP and deamidated COMP (D-COMP). Unpaired AKU, OA and non-OA samples were compared by non-parametric Mann-Whitney U test. Despite more extractable total protein being obtained from AKU cartilage than from OA or non-OA cartilage, there was significantly less extractable GAG, COMP and D-COMP in AKU samples compared with OA and non-OA comparators. Racemized Asx (aspartate and asparagine) was significantly enriched in AKU cartilage compared with in OA cartilage. These novel data represent the first examination of cartilage matrix components in a sample of patients with AKU, representing almost 10% of the known UK alkaptonuric population. Compared with OA and non-OA, AKU cartilage demonstrates a very low turnover state and has low levels of extractable matrix proteins. © The Author 2016. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing

PubMed Central

Hsueh, Ming-Feng; Ranganath, Lakshminarayan R.; Gallagher, James A.; Dillon, Jane P.; Huebner, Janet L.; Catterall, Jon B.; Kraus, Virginia B.

2017-01-01

Objective. Alkaptonuria (AKU) is a rare autosomal recessive disease resulting from a single enzyme deficiency in tyrosine metabolism. As a result, homogentisic acid cannot be metabolized, causing systemic increases. Over time, homogentisic acid polymerizes and deposits in collagenous tissues, leading to ochronosis. Typically, this occurs in joint cartilages, leading to an early onset, rapidly progressing osteoarthropathy. The aim of this study was to examine tissue turnover in cartilage affected by ochronosis and its role in disease initiation and progression. Methods. With informed patient consent, hip and knee cartilages were obtained at surgery for arthropathy due to AKU (n = 6; 2 knees/4 hips) and OA (n = 12; 5 knees/7 hips); healthy non-arthritic (non-OA n = 6; 1 knee/5 hips) cartilages were obtained as waste from trauma surgery. We measured cartilage concentrations (normalized to dry weight) of racemized aspartate, GAG, COMP and deamidated COMP (D-COMP). Unpaired AKU, OA and non-OA samples were compared by non-parametric Mann–Whitney U test. Results. Despite more extractable total protein being obtained from AKU cartilage than from OA or non-OA cartilage, there was significantly less extractable GAG, COMP and D-COMP in AKU samples compared with OA and non-OA comparators. Racemized Asx (aspartate and asparagine) was significantly enriched in AKU cartilage compared with in OA cartilage. Conclusions. These novel data represent the first examination of cartilage matrix components in a sample of patients with AKU, representing almost 10% of the known UK alkaptonuric population. Compared with OA and non-OA, AKU cartilage demonstrates a very low turnover state and has low levels of extractable matrix proteins. PMID:28028161

SU-F-T-499: Anatomic Features for Selection of Electronic Tissue Compensation Radiotherapy in Early-Stage Breast Cancer Patients After Breast-Conserving Surgery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Song, Y; Gan, L; Chen, X

Purpose: To explore the correlations between anatomic features and dose-volumetric parameters in 3DCRT and eComp whole breast irradiation and identify the feasibility of anatomic parameters to predict the planning method selection. Methods: We compared the effectiveness between conventional three-dimensional conformal radiotherapy (3DCRT) and electronic tissue compensation (eComp) for whole breast irradiation. 3DCRT and eComp planning techniques were used to generate treatment plans for 60 whole breast patients, respectively. The planning goal was to cover 95% of the planning target volume (PTV) with 95% of the prescription dose while minimizing dose to lung, heart, and skin. Statistical analyses were performed betweenmore » critical organ doses and patient anatomic features, i.e., central lung distance (CLD), maximal heart distance (MHD), maximal heart length (MHL) and breast separation (BS). Results: Comparing to 3DCRT plans, on the average, eComp treatment planning process was about 7 minutes longer, but resulted in lower lung V20Gy, lower mean skin dose, with similar heart dose. The benefits were more pronounced for larger breast patients. To keep the lung V20Gy lower than 20% and mean skin dose lower than 85% of the prescription dose, eComp was the preferred method for patients with more than 2.3 cm CLD or larger than 22.5 cm BS. Conclusion: The study results may be useful in providing a handy criterion in clinical practice allowing us to easily choose between different planning techniques to satisfy the planning goal with minimal increase in complexity and cost. This study was supported by National Natural Science Foundation of China (NO. 31420103915) and Chongqing Health and Family Planning Commission Project (2015MSXM012).« less

CoAP-Based Mobility Management for the Internet of Things

PubMed Central

Chun, Seung-Man; Kim, Hyun-Su; Park, Jong-Tae

2015-01-01

Most of the current mobility management protocols such as Mobile IP and its variants standardized by the IETF may not be suitable to support mobility management for Web-based applications in an Internet of Things (IoT) environment. This is because the sensor nodes have limited power capacity, usually operating in sleep/wakeup mode in a constrained wireless network. In addition, sometimes the sensor nodes may act as the server using the CoAP protocol in an IoT environment. This makes it difficult for Web clients to properly retrieve the sensing data from the mobile sensor nodes in an IoT environment. In this article, we propose a mobility management protocol, named CoMP, which can effectively retrieve the sensing data of sensor nodes while they are moving. The salient feature of CoMP is that it makes use of the IETF CoAP protocol for mobility management, instead of using Mobile IP. Thus CoMP can eliminates the additional signaling overhead of Mobile IP, provides reliable mobility management, and prevents the packet loss. CoMP employs a separate location management server to keep track of the location of the mobile sensor nodes. In order to prevent the loss of important sensing data during movement, a holding mode of operation has been introduced. All the signaling procedures including discovery, registration, binding and holding have been designed by extending the IETF CoAP protocol. The numerical analysis and simulation have been done for performance evaluation in terms of the handover latency and packet loss. The results show that the proposed CoMP is superior to previous mobility management protocols, i.e., Mobile IPv4/v6 (MIPv4/v6), Hierarchical Mobile IPv4/v6 (HMIPv4/v6), in terms of the handover latency and packet loss. PMID:26151214

The CompHP core competencies framework for health promotion in Europe.

PubMed

Barry, Margaret M; Battel-Kirk, Barbara; Dempsey, Colette

2012-12-01

The CompHP Project on Developing Competencies and Professional Standards for Health Promotion in Europe was developed in response to the need for new and changing health promotion competencies to address health challenges. This article presents the process of developing the CompHP Core Competencies Framework for Health Promotion across the European Union Member States and Candidate Countries. A phased, multiple-method approach was employed to facilitate a consensus-building process on the development of the core competencies. Key stakeholders in European health promotion were engaged in a layered consultation process using the Delphi technique, online consultations, workshops, and focus groups. Based on an extensive literature review, a mapping process was used to identify the core domains, which informed the first draft of the Framework. A consultation process involving two rounds of a Delphi survey with national experts in health promotion from 30 countries was carried out. In addition, feedback was received from 25 health promotion leaders who participated in two focus groups at a pan-European level and 116 health promotion practitioners who engaged in four country-specific consultations. A further 54 respondents replied to online consultations, and there were a number of followers on various social media platforms. Based on four rounds of redrafting, the final Framework document was produced, consisting of 11 core domains and 68 core competency statements. The CompHP Core Competencies Framework for Health Promotion provides a resource for workforce development in Europe, by articulating the necessary knowledge, skills, and abilities that are required for effective practice. The core domains are based on the multidisciplinary concepts, theories, and research that make health promotion distinctive. It is the combined application of all the domains, the knowledge base, and the ethical values that constitute the CompHP Core Competencies Framework for Health Promotion.

Recovery of episodic memory subprocesses in mild and complicated mild traumatic brain injury at 1 and 12 months post injury.

PubMed

Tayim, Fadi M; Flashman, Laura A; Wright, Matthew J; Roth, Robert M; McAllister, Thomas W

2016-11-01

Episodic memory complaints are commonly reported after traumatic brain injury (TBI). The contributions of specific memory subprocesses (encoding, consolidation, and retrieval), however, are not well understood in mild TBI (mTBI). In the present study, we evaluated subprocesses of episodic memory in patients with mTBI using the item-specific deficit approach (ISDA), which analyzes responses on list learning tasks at an item level. We also conducted exploratory analyses to evaluate the effects of complicated mTBI (comp-mTBI) on memory. We compared episodic verbal memory performance in mTBI (n = 92) at approximately 1 and 12 months post TBI, as well as in a healthy comparison (HC) group (n = 40) at equivalent time points. Episodic memory was assessed using the California Verbal Learning Test-2nd Edition (CVLT-II), and both standard CVLT-II scores and ISDA indices were evaluated. Compared to the HC group, the mTBI group showed significantly poorer encoding and learning across time, as measured by ISDA and CVLT-II. Further analyses of these mTBI subgroups [(noncomplicated mTBI (NC-mTBI, n = 77) and comp-mTBI (n = 15)], indicated that it was the comp-mTBI group who continued to demonstrate poorer encoding ability than the HC group. When the patient groups were directly compared, the NC-mTBI group improved slightly on the ISDA Encoding Deficit Index. While the comp-mTBI group worsened slightly over time, their poorer encoding ability was not likely clinically meaningful. These findings indicate that, while the NC-mTBI and HC groups' performances were comparable by 12 months, a primary, long-term deficit in encoding of auditory verbal information remained problematic in the comp-mTBI group.

Digital optical computer II

NASA Astrophysics Data System (ADS)

Guilfoyle, Peter S.; Stone, Richard V.

1991-12-01

OptiComp is currently completing a 32-bit, fully programmable digital optical computer (DOC II) that is designed to operate in a UNIX environment running RISC microcode. OptiComp's DOC II architecture is focused toward parallel microcode implementation where data is input in a dual rail format. By exploiting the physical principals inherent to optics (speed and low power consumption), an architectural balance of optical interconnects and software code efficiency can be achieved including high fan-in and fan-out. OptiComp's DOC II program is jointly sponsored by the Office of Naval Research (ONR), the Strategic Defense Initiative Office (SDIO), NASA space station group and Rome Laboratory (USAF). This paper not only describes the motivational basis behind DOC II but also provides an optical overview and architectural summary of the device that allows the emulation of any digital instruction set.

Ada (Trade Name) Compiler Validation Summary Report: Alsys Inc., AlsyCOMP 003, V3.1, Wang PC 280.

DTIC Science & Technology

1988-06-04

Compiler /a tidation Capability. A set of programs that evaluates the conformity of a compiler to the Ada languaJe speci ficat.ion, AIST/MIL-STD--18... Engineering *Ada o ;; ,es~ered trademark of the United States Government (Ada Joint Program Office) A-2 "- S.! ’S APPENDIX B APPENDIX F OF THE Ada...AND ADDRESS 10. PROGRAM ELEMENT, PROJECT. TASK The National Computing Centre Limited AREA & WORK UNIT NUMBERS Manchester, UK ŕ 11. CONTROLLING OFFICE

Development and Evaluation of an Airplane Fuel Tank Ullage Composition Model. Volume 2. Experimental Determination of Airplane Fuel Tank Ullage Compositions

DTIC Science & Technology

1987-10-01

Airplane Fuel Tank Ullage Compositions ~C A. J. Roth BOEING MILITARY AIRPLANE COMPANY P. 0. Box 3707 Seattle, Washington 98124-2207 October 1987 FINAL...controlled mission simulations were made using the ModComp computer to control the Simulated Aircraft Fuel Tank Environment ( SAFTEI facility at Wright...of this report. iii PREFACE This is a final report of work conducted under F33615-84-C-2431 and submitted by the Boeing Military Airplane Company

Integrity Assessment of E1-E3 Sailors at Naval Submarine School: FY2007 - FY2011

DTIC Science & Technology

2012-01-01

5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Submarine Learning Center,Groton,CT,06349 8. PERFORMING... ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT...School, FT “A” School, STS“A” School, BESS, ATT E-CORE, TACT COMPS, SUB OFF BASIC, SOIC , CSRR Operator, and Basic Mechanical Skills. Submarine

75 FR 20393 - Investigations Regarding Certifications of Eligibility to Apply for Worker Adjustment Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-19

..., Inc. (Wkrs). Austin, TX 03/17/10 03/16/10 73735 Product Action (ONE-ST).... Dayton, OH 03/17/10 03/05... Health Care (Wkrs)... Irving, TX 03/17/10 03/15/10 73721 RCL Burco, Inc. (COMP)..... Culloden, WV 03/17.../10 03/15/10 (STATE). 73725 Michaels (Wkrs) Irving, TX 03/17/10 03/10/10 73726 Pentair Water (COMP...

Research into language concepts for the mission control center

NASA Technical Reports Server (NTRS)

Dellenback, Steven W.; Barton, Timothy J.; Ratner, Jeremiah M.

1990-01-01

A final report is given on research into language concepts for the Mission Control Center (MCC). The Specification Driven Language research is described. The state of the image processing field and how image processing techniques could be applied toward automating the generation of the language known as COmputation Development Environment (CODE or Comp Builder) are discussed. Also described is the development of a flight certified compiler for Comps.

util_2comp: Planck-based two-component dust model utilities

NASA Astrophysics Data System (ADS)

Meisner, Aaron

2014-11-01

The util_2comp software utilities generate predictions of far-infrared Galactic dust emission and reddening based on a two-component dust emission model fit to Planck HFI, DIRBE and IRAS data from 100 GHz to 3000 GHz. These predictions and the associated dust temperature map have angular resolution of 6.1 arcminutes and are available over the entire sky. Implementations in IDL and Python are included.

Effects of Dicto-Comp and Dictation on the Writing Skill of Female Adult Iranian EFL Learners

ERIC Educational Resources Information Center

Adel, Rahil; Hashemian, Mahmood

2015-01-01

This study was an attempt to clarify and remind L2 learners/teachers of 2 kinds of writing: dicto-comp and dictation. We explored the effect of controlled writing on the accuracy of the writing of adult Iranian EFL learners. Prior to the study, the homogeneity of 30 adult EFL learners was checked through an OPT test. Thirty participants were…

Characterization of Air Emissions from Open Burning and Open Detonation of Gun Propellants and Ammunition

DTIC Science & Technology

2016-11-07

To) 4. TITLE AND SUBTITLE Innovative Technology Development for Comprehensive Air Quality Characterization from Soil -Covered Open Detonation of...the short duration of the event, the heterogeneous emission concentra- tions, large plume lift, soil entrainment, and explosive safety restrictions...energetics and cased munitions, including Comp B, V453, and V548 munitions, were detonated without soil cover (only Comp B) or at soil cover depths of 3

Mesomelic dwarfism in pseudoachondroplasia.

PubMed

Song, Hae-Ryong; Li, Qi-Wei; Oh, Chang-Wug; Lee, Kwang-Soo; Koo, Soo Kyung; Jung, Sung-Chul

2004-09-01

Pseudoachondroplasia (PSACH) is associated with mutations in the cartilage oligomeric matrix protein (COMP) gene and the clinical characteristics include short stature, deformities of the extremities involving the epiphyses and metaphyses, early onset arthritis, and ligament laxity. PSACH has been considered a rhizomelic form of dwarfism. So far no previous report has described mesomelic shortening of the limbs in PSACH. We reviewed nine patients with a diagnosis of PSACH based on clinical and radiographic examination and mutation analysis of the COMP gene. The mean height in the adults was 116 cm. All patients showed mesomelic dwarfism. The average ratios of radial length to humeral length and tibial length to femoral length were 0.62 and 0.63, respectively. The tibia and the radius showed more severe bony deformity than the femur and humerus. The degree of short stature was related to the site of the mutation in the COMP gene, but there was no correlation between bony deformity and height or gene mutation.

Magnetic Nulls and Super-radial Expansion in the Solar Corona

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gibson, Sarah E.; Dalmasse, Kevin; Tomczyk, Steven

Magnetic fields in the Sun’s outer atmosphere—the corona—control both solar-wind acceleration and the dynamics of solar eruptions. We present the first clear observational evidence of coronal magnetic nulls in off-limb linearly polarized observations of pseudostreamers, taken by the Coronal Multichannel Polarimeter (CoMP) telescope. These nulls represent regions where magnetic reconnection is likely to act as a catalyst for solar activity. CoMP linear-polarization observations also provide an independent, coronal proxy for magnetic expansion into the solar wind, a quantity often used to parameterize and predict the solar wind speed at Earth. We introduce a new method for explicitly calculating expansion factorsmore » from CoMP coronal linear-polarization observations, which does not require photospheric extrapolations. We conclude that linearly polarized light is a powerful new diagnostic of critical coronal magnetic topologies and the expanding magnetic flux tubes that channel the solar wind.« less

SDN-controlled topology-reconfigurable optical mobile fronthaul architecture for bidirectional CoMP and low latency inter-cell D2D in the 5G mobile era.

PubMed

Cvijetic, Neda; Tanaka, Akihiro; Kanonakis, Konstantinos; Wang, Ting

2014-08-25

We demonstrate the first SDN-controlled optical topology-reconfigurable mobile fronthaul (MFH) architecture for bidirectional coordinated multipoint (CoMP) and low latency inter-cell device-to-device (D2D) connectivity in the 5G mobile networking era. SDN-based OpenFlow control is used to dynamically instantiate the CoMP and inter-cell D2D features as match/action combinations in control plane flow tables of software-defined optical and electrical switching elements. Dynamic re-configurability is thereby introduced into the optical MFH topology, while maintaining back-compatibility with legacy fiber deployments. 10 Gb/s peak rates with <7 μs back-to-back transmission latency and 29.6 dB total power budget are experimentally demonstrated, confirming the attractiveness of the new approach for optical MFH of future 5G mobile systems.

Improved Cook-off Modeling of Multi-component Cast Explosives

NASA Astrophysics Data System (ADS)

Nichols, Albert

2017-06-01

In order to understand the hazards associated with energetic materials, it is important to understand their behavior in adverse thermal environments. These processes have been relatively well understood for solid explosives, however, the same cannot be said for multi-component melt-cast explosives. Here we describe the continued development of ALE3D, a coupled thermal/chemical/mechanical code, to improve its description of fluid explosives. The improved physics models include: 1) Chemical potential driven species segregation. This model allows us to model the complex flow fields associated with the melting and decomposing Comp-B, where the denser RDX tends to settle and the decomposing gasses rise, 2) Automatically scaled stream-wise diffusion model for thermal, species, and momentum diffusion. These models add sufficient numerical diffusion in the direction of flow to maintain numerical stability when the system is under resolved, as occurs for large systems. And 3) a slurry viscosity model, required to properly define the flow characteristics of the multi-component fluidized system. These models will be demonstrated on a simple Comp-B system. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under contract DE-AC52-07NA27344.

cAMP and in vivo hypoxia induce tob, ifr1, and fos expression in erythroid cells of the chick embryo.

PubMed

Dragon, Stefanie; Offenhäuser, Nina; Baumann, Rosemarie

2002-04-01

During avian embryonic development, terminal erythroid differentiation occurs in the circulation. Some of the key events, such as the induction of erythroid 2,3-bisphosphoglycerate (2,3-BPG), carbonic anhydrase (CAII), and pyrimidine 5'-nucleotidase (P5N) synthesis are oxygen dependent (Baumann R, Haller EA, Schöning U, and Weber M, Dev Biol 116: 548-551, 1986; Dragon S and Baumann R, Am J Physiol Regulatory Integrative Comp Physiol 280: R870-R878, 2001; Dragon S, Carey C, Martin K, and Baumann R, J Exp Biol 202: 2787-2795, 1999; Dragon S, Glombitza S, Götz R, and Baumann R, Am J Physiol Regulatory Integrative Comp Physiol 271: R982-R989, 1996; Dragon S, Hille R, Götz R, and Baumann R, Blood 91: 3052-3058, 1998; Million D, Zillner P, and Baumann R, Am J Physiol Regulatory Integrative Comp Physiol 261: R1188-R1196, 1991) in an indirect way: hypoxia stimulates the release of norepinephrine (NE)/adenosine into the circulation (Dragon et al., J Exp Biol 202: 2787-2795, 1999; Dragon et al., Am J Physiol Regulatory Integrative Comp Physiol 271: R982-R989, 1996). This leads via erythroid beta-adrenergic/adenosine A(2) receptor activation to a cAMP signal inducing several proteins in a transcription-dependent manner (Dragon et al., Am J Physiol Regulatory Integrative Comp Physiol 271: R982-R989, 1996; Dragon et al., Blood 91: 3052-3058, 1998; Glombitza S, Dragon S, Berghammer M, Pannermayr M, and Baumann R, Am J Physiol Regulatory Integrative Comp Physiol 271: R973-R981, 1996). To understand how the cAMP-dependent processes are initiated, we screened an erythroid cDNA library for cAMP-regulated genes. We detected three genes that were strongly upregulated (>5-fold) by cAMP in definitive and primitive red blood cells. They are homologous to the mammalian Tob, Ifr1, and Fos proteins. In addition, the genes are induced in the intact embryo during short-term hypoxia. Because the genes are regulators of proliferation and differentiation in other cell types, we suggest that cAMP might promote general differentiating processes in erythroid cells, thereby allowing adaptive modulation of the latest steps of erythroid differentiation during developmental hypoxia.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Delaney, Alexander R., E-mail: a.delaney@vumc.nl; Tol, Jim P.; Dahele, Max

Purpose: RapidPlan, a commercial knowledge-based planning solution, uses a model library containing the geometry and associated dosimetry of existing plans. This model predicts achievable dosimetry for prospective patients that can be used to guide plan optimization. However, it is unknown how suboptimal model plans (outliers) influence the predictions or resulting plans. We investigated the effect of, first, removing outliers from the model (cleaning it) and subsequently adding deliberate dosimetric outliers. Methods and Materials: Clinical plans from 70 head and neck cancer patients comprised the uncleaned (UC) Model{sub UC}, from which outliers were cleaned (C) to create Model{sub C}. The lastmore » 5 to 40 patients of Model{sub C} were replanned with no attempt to spare the salivary glands. These substantial dosimetric outliers were reintroduced to the model in increments of 5, creating Model{sub 5} to Model{sub 40} (Model{sub 5-40}). These models were used to create plans for a 10-patient evaluation group. Plans from Model{sub UC} and Model{sub C}, and Model{sub C} and Model{sub 5-40} were compared on the basis of boost (B) and elective (E) target volume homogeneity indexes (HI{sub B}/HI{sub E}) and mean doses to oral cavity, composite salivary glands (comp{sub sal}) and swallowing (comp{sub swal}) structures. Results: On average, outlier removal (Model{sub C} vs Model{sub UC}) had minimal effects on HI{sub B}/HI{sub E} (0%-0.4%) and sparing of organs at risk (mean dose difference to oral cavity and comp{sub sal}/comp{sub swal} were ≤0.4 Gy). Model{sub 5-10} marginally improved comp{sub sal} sparing, whereas adding a larger number of outliers (Model{sub 20-40}) led to deteriorations in comp{sub sal} up to 3.9 Gy, on average. These increases are modest compared to the 14.9 Gy dose increases in the added outlier plans, due to the placement of optimization objectives below the inferior boundary of the dose-volume histogram-predicted range. Conclusions: Overall, dosimetric outlier removal from or addition of 5 to 10 outliers to a 70-patient model had marginal effects on resulting plan quality. Although the addition of >20 outliers deteriorated plan quality, the effect was modest. In this study, RapidPlan demonstrated robustness for moderate proportions of salivary gland dosimetric outliers.« less

Deployed Flight Test of the Iraqi Air Force Comp Air 7SLX (CA-7)

DTIC Science & Technology

2014-02-28

making. 15. SUBJECT TERMS CA-7 aircraft; Comp Air 7SLX aircraft; Iraq; developmental test and evaluation; turboprop aircraft; composite aircraft...high-wing, six-seat composite aircraft was powered by a Walter M601 657 horsepower turboprop engine. The engine, manufactured in the Czech Republic...Major Charles Stuart Farmer of the AFFTC’s Safety Office, who had experience with the small, turboprop - powered Beechcraft T-6 Texan II, was the

78 FR 76738 - Updated Statements of Legal Authority for the Export Administration Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-19

... 13637 of March 8, 2013, 78 FR 16129 (March 13, 2013), and as extended by the Notice of August 8, 2013.... 5; 22 U.S.C. 7201 et seq.; 22 U.S.C. 7210; E.O. 11912, 41 FR 15825, 3 CFR, 1976 Comp., p. 114; E.O.... 13338, 69 FR 26751, 3 CFR, 2004 Comp., p 168; E.O. 13637 of March 8, 2013, 78 FR 16129 (March 13, 2013...

Virtual identification of novel PPARα/γ dual agonists by scaffold hopping of saroglitazar.

PubMed

Jia, Wen-Qing; Jing, Zhi; Liu, Xin; Feng, Xiao-Yan; Liu, Ya-Ya; Wang, Shu-Qing; Xu, Wei-Ren; Liu, Jian-Wen; Cheng, Xian-Chao

2017-10-28

The thiazolidinedione class PPARγ agonists as antidiabetic agents are restricted in clinical use because of the side effects such as edema, weight gain, and heart failure. The single and selective agonism of PPARγ is the main cause of side effects. The multi-target cooperative PPARα/γ dual agonist development is a hot topic in the antidiabetic medicinal chemistry field. Saroglitazar is the first approved PPARα/γ dual agonist, available in India for the treatment of diabetic dyslipidemia. It got rid of these side effects. With the aim of finding more protent PPARα/γ dual agonists, the scaffold hopping was used to replace α-o phenylpropionic acid skeleton of saroglitazar with L-tyrosine skeleton. Then, the structural modification was carried out designing 72 compounds. Considering the importance of chirality, opposite configuration of 72 compounds was also studied. 12 compounds with better -cdocker energy were screened by molecular docking. Subsequently, the pharmacokinetic properties and toxicity evaluated by ADMET prediction, 11 of them showed better properties. Comp#L-17-1 and comp#L-3-1 were regarded as representatives to study the binding stability by molecular dynamics (MD) simulations. The MD simulation results of comp#L-17-1-PPARs (α, γ) and comp#L-3-1-PPARs (α, γ) provided structure reference for the research and development of novel PPARα/γ dual agonists.

Multivalent recombinant proteins for probing functions of leucocyte surface proteins such as the CD200 receptor

PubMed Central

Voulgaraki, Despina; Mitnacht-Kraus, Rita; Letarte, Michelle; Foster-Cuevas, Mildred; Brown, Marion H; Neil Barclay, A

2005-01-01

CD200 (OX2) is a membrane glycoprotein that interacts with a structurally related receptor (CD200R) involved in the regulation of macrophage function. The interaction is of low affinity (KD ∼ 1 μm) but can be detected using CD200 displayed in a multivalent form on beads or with dimeric fusion proteins consisting of the extracellular region of CD200 and immunoglobulin Fc regions. We prepared putative pentamers and trimers of mouse CD200 with sequences from cartilage oligomeric matrix protein (COMP) and surfactant protein D (SP-D), respectively. The COMP protein gave high-avidity binding and was a valuable tool for showing the interaction whilst the SP-D protein gave weak binding. In vivo experiments showed that an agonistic CD200R monoclonal antibody caused some amelioration in a model of experimental autoimmune encephalomyelitis but the COMP protein was cleared rapidly and had minimal effect. Pentameric constructs also allowed detection of the rat CD48/CD2 interaction, which is of much lower affinity (KD ∼ 70 μm). These reagents may have an advantage over Fc-bearing hybrid molecules for probing cell surface proteins without side-effects due to the Fc regions. The CD200-COMP gave strong signals in protein microarrays, suggesting that such reagents may be valuable in high throughput detection of weak interactions. PMID:15946251

Estimation of Solvation Quantities from Experimental Thermodynamic Data: Development of the Comprehensive CompSol Databank for Pure and Mixed Solutes

NASA Astrophysics Data System (ADS)

Moine, Edouard; Privat, Romain; Sirjean, Baptiste; Jaubert, Jean-Noël

2017-09-01

The Gibbs energy of solvation measures the affinity of a solute for its solvent and is thus a key property for the selection of an appropriate solvent for a chemical synthesis or a separation process. More fundamentally, Gibbs energies of solvation are choice data for developing and benchmarking molecular models predicting solvation effects. The Comprehensive Solvation—CompSol—database was developed with the ambition to propose very large sets of new experimental solvation chemical-potential, solvation entropy, and solvation enthalpy data of pure and mixed components, covering extended temperature ranges. For mixed compounds, the solvation quantities were generated in infinite-dilution conditions by combining experimental values of pure-component and binary-mixture thermodynamic properties. Three types of binary-mixture properties were considered: partition coefficients, activity coefficients at infinite dilution, and Henry's-law constants. A rigorous methodology was implemented with the aim to select data at appropriate conditions of temperature, pressure, and concentration for the estimation of solvation data. Finally, our comprehensive CompSol database contains 21 671 data associated with 1969 pure species and 70 062 data associated with 14 102 binary mixtures (including 760 solvation data related to the ionic-liquid class of solvents). On the basis of the very large amount of experimental data contained in the CompSol database, it is finally discussed how solvation energies are influenced by hydrogen-bonding association effects.

Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression.

PubMed

McCarrel, Taralyn; Fortier, Lisa

2009-08-01

Platelet-rich plasma (PRP) has generated substantial interest for tendon and ligament regeneration because of the high concentrations of growth factors in platelet alpha-granules. This study compared the temporal release of growth factors from bone marrow aspirate (BMA), PRP, and lyophilized platelet product (PP), and measured their effects on tendon and ligament gene expression. Blood and BMA were collected and processed to yield PRP and plasma. Flexor digitorum superficialis tendon (FDS) and suspensory ligament (SL) explants were cultured in 10% plasma in DMEM (control), BMA, PRP, or PP. TGF-beta1 and PDGF-BB concentrations were determined at 0, 24, and 96 h of culture using ELISA. Quantitative RT-PCR for collagen types I and III (COL1A1, COL3A1), cartilage oligomeric matrix protein (COMP), decorin, and matrix metalloproteinases-3 and 13 (MMP-3, MMP-13) was performed. TGF-beta1 and PDGF-BB concentrations were highest in PRP and PP. Growth factor quantity was unchanged in BMA, increased in PRP, and decreased in PP over 4 days. TGF-beta1 and platelet concentrations were positively correlated. Lyophilized PP and PRP resulted in increased COL1A1:COL3A1 ratio, increased COMP, and decreased MMP-13 expression. BMA resulted in decreased COMP and increased MMP-3 and MMP-13 gene expression. Platelet concentration was positively correlated with COL1A1, ratio of COL1A1:COL3A1, and COMP, and negatively correlated with COL3A1, MMP-13, and MMP-3. White blood cell concentration was positively correlated with COL3A1, MMP3, and MMP13, and negatively correlated with a ratio of COL1A1:COL3A1, COMP, and decorin. These findings support further in vivo investigation of PRP and PP for treatment of tendonitis and desmitis. Copyright 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

La contribution de la diversité des expériences littéraires préscolaires aux habiletés émergentes en littéracie

PubMed Central

PARENT, Sophie; MONTÉSINOS-GELET, Isabelle; SÉGUIN, Jean R.; ZELAZO, Philip David; TREMBLAY, Richard E.

2017-01-01

RÉSUMÉ Les études antérieures montrent que les facteurs langagiers et cognitifs chez le jeune enfant ne suffisent pas pour expliquer les différences individuelles dans l’acquisition des compétences relatives à la langue écrite (Sénéchal et LeFevre, 2002). S’inspirant de l’éthologie et de la sociologie, Pellegrini (2001) propose que l’exposition à une plus grande variété d’interlocuteurs et de contextes sociaux pour l’exercice des compétences liées à l’écrit favorise l’acquisition du langage littéraire et des compétences en lecture/écriture. La présente étude a pour but de vérifier cette contribution de la variété des opportunités sociales reliées à l’écrit à l’acquisition des compétences émergentes en littéracie à 5 ans. Cette contribution est examinée de concert avec les ressources financières familiales, l’éducation parentale, la fréquence des activités mère-enfant de lecture/écriture et les compétences verbales et mnémoniques de l’enfant. Les résultats confirment partiellement l’hypothèse de Pellegrini et appuient la pertinence de considérer plusieurs dimensions des expériences sociales préscolaires. La contribution unique de la diversité des activités littéraires de l’enfant à 48 mois s’avère de taille similaire à celle du vocabulaire réceptif évalué à 42 mois et de la mémoire à court terme à 42 mois. La diversité des interlocuteurs n’ajoute toutefois pas au modèle. PMID:28566801

Productivity of Senior Dental Students Engaged in Comprehensive Care: A Seven-Year Follow-Up Study.

PubMed

Blalock, John S; Callan, Richard S; Mollica, Anthony G

2017-04-01

The aims of this study were to determine the trend of senior dental students' rate of production of clinical procedures performed in the comprehensive care clinic at one U.S. dental school and to compare that trend to what was reported immediately following inception of that clinic. In addition, total clinic revenues collected were recorded and compared. The periods used for comparisons were 2005 and 2006 combined, the last years before introduction of comprehensive care (called "pre-comp care"); 2007 and 2008 combined, the first two years of comprehensive care (called "post-comp care"); and subsequent years through 2014. The number of procedures and total charges were tracked in the electronic health record, and the total number of student-hours was calculated by multiplying the number of students in the class by the total number of available clinic hours. The rate calculated in this way was then multiplied by a factor of 1,000 for ease of interpretation. The results showed a generally upward trend and a significant increase from post-comp care to 2014 for all procedures combined and for indirect restorations. There was a generally downward trend and a significant decrease from post-comp care to 2014 for direct restorations, extractions, and root planing. There was some up and down fluctuation but no significant change from post-comp care to 2014 for exams. In terms of all procedures, the rate per student/1,000 clinic hours increased from approximately 227 to 419, an 85% increase over seven years. These results show that implementation of the comprehensive care clinic model of clinical education has increased the total clinical productivity of senior dental students at this dental school. Additional studies are indicated to determine the proper balance between a quality education and the financial capabilities of the institution.

Simulated Rainfall-Driven Dissolution of TNT, Tritonal, Comp B and Octol Particles

DTIC Science & Technology

2009-01-01

Comp B a b s t r a c t Live-fire military training can deposit millimeter- sized particles of high explosives (HE) on surface soils when rounds do not...might dissolve under the action of rainfall and to use the data to verify a model that predicts HE dissolution as a function of particle size , particle...Detonations scatter HE particles broadly over surface soils. High-order detonations scatter lm- size HE particles and low-order (LO) detonations scatter

High Temperature Advanced Structural Composites. Volume 2. Ceramic Matrix Composites, Fiber Processing and Properties, and Interfaces

DTIC Science & Technology

1993-04-02

1977) 97. 3 W. Wieswieler, E. Fitzer, G . Nagel, and H. Jager, Thin Solid Film, 148 (1987) 93. 4 T. A. Chernyshova , L. I. Kobelova, J. Mater. Scl., 20...AD-A267 023 I[E[gh ’Temperature kdvanced Structural (Composites Rensselaer Polytechnic Institute , \\ G Troy, N. Y. 12180-3590 - Final Report -- Book 2...thermodynamic data (heats of forma- ,(T p, comp.) °+p, comp.) (1) tion, absolute entropies, heat capacities) of reactants where g ’ is the chemical

A Comparative Study of Very High Burning Rate Materials - HIVELITE compositions 300511 and 300435

DTIC Science & Technology

1982-08-01

explosives and more or as sensitive as RDX and HMX . Thermal Sensitivity Differential Thermal Analysis/Thermogravimetric Analysis (DTA/TGA) Simultaneous...impact than Comp B end RDX but is less sensitive than lead azide. HIVELITE 30051i on the other hand, is less sensitive than Comp B and RDX on the ERL...represents the alpha to beta phase transition of KNO 3 . This endotherm is followed by four exotherms with peaks at 538 K (265*C), 567 K (2940C), 598 K

Short communication: Estimation of yield stress/viscosity of molten octol

DOE PAGES

Davis, S. M.; Zerkle, D. K.

2018-05-04

Explosive HMX particles are similar in morphology and chemistry to RDX particles, the main constituent of Composition B-3 (Comp B-3). This suggests molten HMX-TNT formulations may show Bingham plasticity, much like recent studies have shown for Comp B-3. Here a Bingham plastic viscosity model, including yield stress and shear thinning, is presented for octol (70/30wt% HMX/TNT) as a function of HMX particle volume fraction. The effect of HMX dissolution into molten TNT is included in this analysis.

Comprehensive Approach Training Toolkit: Training Needs Analysis

DTIC Science & Technology

2013-03-01

design pertinent sit e training on . A tool such able 14 summ Global MedAi The research w global and fund War Program. The menu has standards...The cultur detail and designed requires. T type inter cultural pr Table 20 s Comp e Cul Onl s Inte equ aintain Sold ann ess Yes Mod onli exce s...Competency developmen Time comm Use by allie Website Comp e Intr es Bec situa at g grad test The Onl It is Acc s The Win 512 DVD

Dollar Summary of Federal Supply Classification and Service Category by Company, FY84, Part 1 (1005-2610).

DTIC Science & Technology

1984-01-01

350 STATE TOTAL 377 NEBRASKA ARMY TRACTORS WHEELED 111 CONTRACTOR TOTAL 488 PINE BUSH EQUIPMENT CO INC NEW YORK ARMY TRACTORS WHEELED 49 PSI MOBILE...ARMY VEHICULAR FURNITURE AND ACCESSORIES 48- AURORA CORD a CABLE CO INC ILLINOIS ARMY VEHICULAR FURNITURE AND ACCESSORIES 211 BARREN RV MTL HTH/MTL...MICHIGAN ARMY VEHICULAR BRAKE STEERING AXLE WHEEL COMP 702 PENN ARMY VEHICULAR BRAKE STEERING AXLE WHEEL COMP 32 CONTRACTOR TOTAL 734 RYAN CHRYSLER PLYMOUTH

Short communication: Estimation of yield stress/viscosity of molten octol

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, S. M.; Zerkle, D. K.

Explosive HMX particles are similar in morphology and chemistry to RDX particles, the main constituent of Composition B-3 (Comp B-3). This suggests molten HMX-TNT formulations may show Bingham plasticity, much like recent studies have shown for Comp B-3. Here a Bingham plastic viscosity model, including yield stress and shear thinning, is presented for octol (70/30wt% HMX/TNT) as a function of HMX particle volume fraction. The effect of HMX dissolution into molten TNT is included in this analysis.

A Request for the Conference and Symposia Grant from COMP Division of American Chemical Society

DTIC Science & Technology

2015-03-02

John Kattirtzi, Joost VandeVondele, Jun Cheng. 4:45 pm 130 Oxidation stability and decomposition reactions of battery electrolytes and additives in bulk...CA Abstracts2View™: http://abstracts.acs.org/chem/248nm/program/divisionindex.php?act=pre... 3 of 5 8/26/2014 8:19 PM 11:10 am 420 DME decomposition ...Nature of electro-osmosis in hydrated polymer electrolyte membranes Yoong-Kee Choe 5:25 pm Concluding Remarks COMP Emilio Esposito, Scott Wildman

Enhanced Bone Formation in Segmental Defects with BMP2 in a Biologically Relevant Molecular Context

DTIC Science & Technology

2016-10-16

gun shots . These do not heal on their own once a ‘critical size’ segment of bone is missing. One strategy to induce healing is to use bone-inducing...accelerate BMP2-induced bone formation by presenting the growth factor in a more biologically relevant context. This is based on our observation...that manganese increases the binding of BMP2 to COMP. The next steps are to validate these observations using BMP2:COMP on HA/PLG scaffolds in-vitro

Responsibility Determinations of Department of Defense Environmental Cleanup Contractors: Caveat Vendori

DTIC Science & Technology

1993-09-01

114 b. DE FACTO SUSPENSIONS/DEBARMENTS ............ 117 c. INTEGRITY & ENVIRONMENTAL CONTRACTS ........ 119 7. COMPLIANCE WITH APPLICABLE LAWS...Dec. 28, 1973); Comp. Gen. Dec. B-135718, 37 Comp. Gen. 798 (May 28, 1958). 294 4 C.F.R. S 21.3(m)(5) (1991); Ingenieria Y Construcciones, S.A., B...Marathon Watch Co., Ltd., B-247043, Apr. 23, 1992, 92- 1 CPD 11 384; Ingenieria Y Construcciones, S.A., B-241043, Dec. 28, 1990, 90-2 CPD 1 524; Garten-und

Short communication: Estimation of yield stress/viscosity of molten octol

NASA Astrophysics Data System (ADS)

Davis, S. M.; Zerkle, D. K.

2018-05-01

Explosive HMX particles are similar in morphology and chemistry to RDX particles, the main constituent of Composition B-3 (Comp B-3). This suggests molten HMX-TNT formulations may show Bingham plasticity, much like recent studies have shown for Comp B-3. Here a Bingham plastic viscosity model, including yield stress and shear thinning, is presented for octol (70/30wt% HMX/TNT) as a function of HMX particle volume fraction. The effect of HMX dissolution into molten TNT is included in this analysis.

34 CFR 85.310 - What must I do if a Federal agency excludes a person with whom I am already doing business in a...

Code of Federal Regulations, 2010 CFR

2010-07-01

... terminate and the type of termination action, if any, only after a thorough review to ensure that the action..., 682.702, or 668.94, as applicable Authority: E.O. 12549 (3 CFR, 1986 Comp., p. 189); E.O 12689 (3 CFR, 1989 Comp., p. 235); 20 U.S.C. 1082, 1094, 1221e-3 and 3474; and Sec. 2455, Pub. L. 103-355, 108 Stat...

Results of the post-U.S. Food and Drug Administration-approval study with a continuous flow left ventricular assist device as a bridge to heart transplantation: a prospective study using the INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support).

PubMed

Starling, Randall C; Naka, Yoshifumi; Boyle, Andrew J; Gonzalez-Stawinski, Gonzalo; John, Ranjit; Jorde, Ulrich; Russell, Stuart D; Conte, John V; Aaronson, Keith D; McGee, Edwin C; Cotts, William G; DeNofrio, David; Pham, Duc Thinh; Farrar, David J; Pagani, Francis D

2011-05-10

The aim of this study was to determine whether results with the HeartMate (HM) II left ventricular assist device (LVAD) (Thoratec Corporation, Pleasanton, California) in a commercial setting are comparable to other available devices for the same indication. After a multicenter pivotal clinical trial conducted from 2005 to 2008, the U.S. Food and Drug Administration approved the HM II LVAD for bridge to transplantation (BTT). A post-approval study was required by the U.S. Food and Drug Administration to determine whether results with the device in a commercial setting are comparable to other available devices for the same indication. The study was a prospective evaluation of the first 169 consecutive HM II patients enrolled in the national INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) who were listed for transplant or likely to be listed. Patients were enrolled from April through August 2008 at 77 U.S. centers and followed for at least 1 year after implant. A comparison group (COMP) included all patients (n = 169 at 27 centers) enrolled in the INTERMACS registry with other types of LVADs (79% HeartMate XVE, 21% Implantable Ventricular Assist Device [Thoratec Corporation]) for the same BTT indication in the same time period. Survival rates, adverse events, and quality of life with the EuroQol EQ-5D visual analog scale were obtained in the INTERMACS registry. Baseline characteristics were similar, but creatinine and blood urea nitrogen were lower in the HM II versus COMP groups, and there were fewer patients in the highest-risk INTERMACS patient profile Number 1 (24% for HM II vs. 39% for COMP). Adverse event rates were similar or lower for HM II versus COMP for all events. Bleeding was the most frequent adverse event for both groups (1.44 vs. 1.79 events/patient-year). Operative 30-day mortality for HM II was 4% versus 11% for COMP. The percentage of patients reaching transplant, cardiac recovery, or ongoing LVAD support by 6 months was 91% for HM II and 80% for COMP, and the Kaplan-Meier survival for patients remaining on support at 1 year was 85% for HM II versus 70% for COMP. Quality of life was significantly improved at 3 months of support and sustained through 12 months in both groups compared with baseline. The results in a post-market approval, actual patient care setting BTT population support the original findings from the pivotal clinical trial regarding the efficacy and risk profile of the HM II LVAD. These data suggest that dissemination of this technology after approval has been associated with continued excellent results. Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Less is more: Sampling chemical space with active learning

NASA Astrophysics Data System (ADS)

Smith, Justin S.; Nebgen, Ben; Lubbers, Nicholas; Isayev, Olexandr; Roitberg, Adrian E.

2018-06-01

The development of accurate and transferable machine learning (ML) potentials for predicting molecular energetics is a challenging task. The process of data generation to train such ML potentials is a task neither well understood nor researched in detail. In this work, we present a fully automated approach for the generation of datasets with the intent of training universal ML potentials. It is based on the concept of active learning (AL) via Query by Committee (QBC), which uses the disagreement between an ensemble of ML potentials to infer the reliability of the ensemble's prediction. QBC allows the presented AL algorithm to automatically sample regions of chemical space where the ML potential fails to accurately predict the potential energy. AL improves the overall fitness of ANAKIN-ME (ANI) deep learning potentials in rigorous test cases by mitigating human biases in deciding what new training data to use. AL also reduces the training set size to a fraction of the data required when using naive random sampling techniques. To provide validation of our AL approach, we develop the COmprehensive Machine-learning Potential (COMP6) benchmark (publicly available on GitHub) which contains a diverse set of organic molecules. Active learning-based ANI potentials outperform the original random sampled ANI-1 potential with only 10% of the data, while the final active learning-based model vastly outperforms ANI-1 on the COMP6 benchmark after training to only 25% of the data. Finally, we show that our proposed AL technique develops a universal ANI potential (ANI-1x) that provides accurate energy and force predictions on the entire COMP6 benchmark. This universal ML potential achieves a level of accuracy on par with the best ML potentials for single molecules or materials, while remaining applicable to the general class of organic molecules composed of the elements CHNO.

Increased serum cartilage oligomeric matrix protein levels and decreased patellar bone mineral density in patients with chondromalacia patellae

PubMed Central

Murphy, E; FitzGerald, O; Saxne, T; Bresnihan, B

2002-01-01

Background: Chondromalacia patellae is a potentially disabling disorder characterised by features of patellar cartilage degradation. Objective: To evaluate markers of cartilage and bone turnover in patients with chondromalacia patellae. Methods: 18 patients with chondromalacia patellae were studied. Serum cartilage oligomeric matrix protein (s-COMP) and bone sialoprotein (s-BSP) levels were measured by enzyme linked immunosorbent assay (ELISA) and compared with those of age and sex matched healthy control subjects. Periarticular bone mineral density (BMD) of both knee joints was assessed by dual energy x ray absorptiometry (DXA). Results: s-COMP levels were significantly raised in all patients with chondromalacia patellae compared with healthy control subjects (p=0.0001). s-BSP levels did not differ significantly between the groups (p=0.41). BMD of the patella was significantly reduced in patients with chondromalacia patellae compared with the control subjects (p=0.016). In patients with bilateral chondromalacia patellae, BMD of the patella was lower in the more symptomatic knee joint (p=0.005). Changes in periarticular BMD were localised to the patella and were not present in femoral regions. Neither s-COMP (p=0.18) nor s-BSP (p=0.40) levels correlated with patellar BMD. Conclusions: Increased s-COMP levels, reflecting cartilage degradation, and reduced BMD localised to the patella may represent clinically useful markers in the diagnosis and monitoring of patients with chondromalacia patellae. Measures of cartilage degradation did not correlate with loss of patellar bone density, suggesting dissociated pathophysiological mechanisms. PMID:12379520

Increased serum cartilage oligomeric matrix protein levels and decreased patellar bone mineral density in patients with chondromalacia patellae.

PubMed

Murphy, E; FitzGerald, O; Saxne, T; Bresnihan, B

2002-11-01

Chondromalacia patellae is a potentially disabling disorder characterised by features of patellar cartilage degradation. To evaluate markers of cartilage and bone turnover in patients with chondromalacia patellae. 18 patients with chondromalacia patellae were studied. Serum cartilage oligomeric matrix protein (s-COMP) and bone sialoprotein (s-BSP) levels were measured by enzyme linked immunosorbent assay (ELISA) and compared with those of age and sex matched healthy control subjects. Periarticular bone mineral density (BMD) of both knee joints was assessed by dual energy x ray absorptiometry (DXA). s-COMP levels were significantly raised in all patients with chondromalacia patellae compared with healthy control subjects (p=0.0001). s-BSP levels did not differ significantly between the groups (p=0.41). BMD of the patella was significantly reduced in patients with chondromalacia patellae compared with the control subjects (p=0.016). In patients with bilateral chondromalacia patellae, BMD of the patella was lower in the more symptomatic knee joint (p=0.005). Changes in periarticular BMD were localised to the patella and were not present in femoral regions. Neither s-COMP (p=0.18) nor s-BSP (p=0.40) levels correlated with patellar BMD. Increased s-COMP levels, reflecting cartilage degradation, and reduced BMD localised to the patella may represent clinically useful markers in the diagnosis and monitoring of patients with chondromalacia patellae. Measures of cartilage degradation did not correlate with loss of patellar bone density, suggesting dissociated pathophysiological mechanisms.

Analysis of composite plates by using mechanics of structure genome and comparison with ANSYS

NASA Astrophysics Data System (ADS)

Zhao, Banghua

Motivated by a recently discovered concept, Structure Genome (SG) which is defined as the smallest mathematical building block of a structure, a new approach named Mechanics of Structure Genome (MSG) to model and analyze composite plates is introduced. MSG is implemented in a general-purpose code named SwiftComp(TM), which provides the constitutive models needed in structural analysis by homogenization and pointwise local fields by dehomogenization. To improve the user friendliness of SwiftComp(TM), a simple graphic user interface (GUI) based on ANSYS Mechanical APDL platform, called ANSYS-SwiftComp GUI is developed, which provides a convenient way to create some common SG models or arbitrary customized SG models in ANSYS and invoke SwiftComp(TM) to perform homogenization and dehomogenization. The global structural analysis can also be handled in ANSYS after homogenization, which could predict the global behavior and provide needed inputs for dehomogenization. To demonstrate the accuracy and efficiency of the MSG approach, several numerical cases are studied and compared using both MSG and ANSYS. In the ANSYS approach, 3D solid element models (ANSYS 3D approach) are used as reference models and the 2D shell element models created by ANSYS Composite PrepPost (ACP approach) are compared with the MSG approach. The results of the MSG approach agree well with the ANSYS 3D approach while being as efficient as the ACP approach. Therefore, the MSG approach provides an efficient and accurate new way to model composite plates.

Detection of piperonal emitted from polymer controlled odor mimic permeation systems utilizing Canis familiaris and solid phase microextraction-ion mobility spectrometry.

PubMed

Macias, Michael S; Guerra-Diaz, Patricia; Almirall, José R; Furton, Kenneth G

2010-02-25

Currently, in the field of odor detection, there is generally a wider variation in limit of detections (LODs) for canines than instruments. The study presented in this paper introduces an improved protocol for the creation of controlled odor mimic permeation system (COMPS) devices for use as standards in canine training and discusses the canine detection thresholds of piperonal, a starting material for the illicit drug 3,4-methylenedioxymethamphetamine (MDMA), when exposed to these devices. Additionally, this paper describes the first-ever reported direct comparison of solid phase microextraction-ion mobility spectrometry (SPME-IMS) to canine detection for the MDMA odorant, piperonal. The research presented shows the reliability of COMPS devices as low cost field calibrants providing a wide range of odorant concentrations for biological and instrumental detectors. The canine LOD of piperonal emanating from the 100 ng s(-1) COMPS was found to be 1 ng as compared to the SPME-IMS LOD of piperonal in a static, closed system at 2 ng, with a linear dynamic range from 2 ng to 11 ng. The utilization of the COMPS devices would allow for training that will reduce the detection variability between canines and maintain improved consistency for training purposes. Since both SPME and IMS are field portable technologies, it is expected that this coupled method will be useful as a complement to canine detection for the field detection of MDMA. 2009 Elsevier Ireland Ltd. All rights reserved.

All-trans retinol, vitamin D and other hydrophobic compounds bind in the axial pore of the five-stranded coiled-coil domain of cartilage oligomeric matrix protein.

PubMed Central

Guo, Y; Bozic, D; Malashkevich, V N; Kammerer, R A; Schulthess, T; Engel, J

1998-01-01

The potential storage and delivery function of cartilage oligomeric matrix protein (COMP) for cell signaling molecules was explored by binding hydrophobic compounds to the recombinant five-stranded coiled-coil domain of COMP. Complex formation with benzene, cyclohexane, vitamin D3 and elaidic acid was demonstrated through increases in denaturation temperatures of 2-10 degreesC. For all-trans retinol and all-trans retinoic acid, an equilibrium dissociation constant KD = 0.6 microM was evaluated by fluorescence titration. Binding of benzene and all-trans retinol into the hydrophobic axial pore of the COMP coiled-coil domain was proven by the X-ray crystal structures of the corresponding complexes at 0.25 and 0.27 nm resolution, respectively. Benzene binds with its plane perpendicular to the pore axis. The binding site is between the two internal rings formed by Leu37 and Thr40 pointing into the pore of the COMP coiled-coil domain. The retinol beta-ionone ring is positioned in a hydrophobic environment near Thr40, and the 1.1 nm long isoprene tail follows a completely hydrophobic region of the pore. Its terminal hydroxyl group complexes with a ring of the five side chains of Gln54. A mutant in which Gln54 is replaced by Ile binds all-trans retinol with affinity similar to the wild-type, demonstrating that hydrophobic interactions are predominant. PMID:9736606

Improved bioavailability and clinical response in patients with chronic liver disease following the administration of a spironolactone: β-cyclodextrin complex

PubMed Central

Abosehmah-Albidy, A. Z. M.; York, P.; Wong, V.; Losowsky, M. S.; Chrystyn, H.

1997-01-01

Aims To compare the absorption and clinical effect of spironolactone from an inclusion complex with β-cyclodextrin (SP-COMP) to Aldactone tablets (ALD) in chronic liver disease. Methods Patients, admitted with chronic liver disease, completed a randomized crossover steady state study. They received their spironolactone dose as either daily SP-COMP or ALD for 7 days. Serial blood samples were drawn over a 24 h period from day 7 of each therapy. Accurate fluid balance was recorded on days 5–7 and 12–14. Thirteen (six females) whose mean (s.d.) age and weight was 58.4(9.3) years and 74.3(19.0) kg completed the study. Results The mean (95% confidence limits) relative bioavailability for SP-COMP (compared with ALD) from steady state serum concentrations of canrenone, 6β-hydroxyl 7α-thiomethyl spironolactone and 7α-thiomethyl spironolactone was 310.0 (265.4, 336.7), 233.4(212.9, 250.8) and 254.8(230.8, 279.0)%, respectively. Improvements in clinical status and fluid balance occurred over the last 3 days of SP-COMP with a mean (s.d.) net loss, in fluid balance, of 1370(860)ml compared with a gain of 228(936)ml during ALD. Conclusions Better absorption of spironolactone from the spironolactone: β-cyclodextrin complex formulation should lead to a reduction in dosage and perhaps a more consistent effect in patients with chronic liver disease. PMID:9241094

Proposed comprehensive ototoxicity monitoring program for VA healthcare (COMP-VA)

PubMed Central

Konrad-Martin, Dawn; Reavis, Kelly M.; McMillan, Garnett; Helt, Wendy J.; Dille, Marilyn

2015-01-01

Prevention and rehabilitation of hearing loss and tinnitus, the two most commonly awarded service-connected disabilities, are high priority initiatives in the Department of Veterans Affairs (VA). At least 4,000 Veterans, most with significant hearing loss, will receive cisplatin this year, with more than half sustaining permanent hearing shift and nearly 40% developing new tinnitus. With improved survivability following cancer treatment, Veterans treated with cisplatin are approached with the dual goals of effective treatment and preserved quality of life. This article describes COMP-VA, a comprehensive ototoxicity monitoring program developed for VA patients receiving cisplatin. The program includes an individualized pretreatment prediction model that identifies the likelihood of hearing shift given cisplatin dose and patient factors. It supports both manual and automated hearing testing with a newly developed portable audiometer capable of performing the recommended procedures on the chemotherapy unit during treatment. It also includes objective methods for identifying outer hair cell changes and predicting audiogram changes using distortion-product otoacoustic emissions. We describe this program of evidence-based ototoxicity monitoring protocols using a case example to give the reader an understanding of how this program would be applied, along with a plan for future work to accomplish the final stages of program development. PMID:24805896

The Communications Toolbox for MATLAB and E0 3513 Laboratory Design

DTIC Science & Technology

1994-03-24

lengtli(quanchj)-1)) sxniejbinnuMs=bin...nums(1:6) %;.. M.asure dhe quantization noise sig-toLia.is~snr(s1 ,quansig); str --numn2str(sigjoQnois); %Plot 4...compressed quantized signal exp..comp=expmnd(quansig2,mu2,tmx(quansi2)); %use maximum signal value =nrw.ccwnp-snr(s,exp~coinp); str -num2str(sir..comp); MPot...8217) ylabelCAmplitude’) grid cig %Part 2--Observe fte differences in the spectra Program mung Laboratory 3B Key-age 3 319 %for two types of pulse-modulatWd signals

On the Computation of Finite Invariant Sets of Mappings.

DTIC Science & Technology

1988-02-01

for the calculation of such invariant cycles. We refer here only to Doedel [1], looss et al [3], Kevrekidis et al [4], Van Veldhuizen ,[6], where further... van Veldhuizen , On Polygonal Approximations of an Invariant Curve, Dept.of Mathem. and Comp. Science, Vrije Universiteit Amsterdam, Techni- cal Report 1987, Math. Comp. to appear DATE Fl .LMED ...of van der Pol’s equation " x2) x - A(l - x ) X’ + x - 0 (16) As shown, for example in [2], the solution satisfies x - 2 cos(wt)+ A (0.75 sin(wt

Replacing wheat with canola meal and maize grain in the diet of lactating dairy cows: Feed intake, milk production and cow condition responses.

PubMed

McDonnell, Ruairi P; Staines, Martin vH

2017-08-01

This research paper describes the effect of partially replacing wheat with maize grain and canola meal on milk production and body condition changes in early lactation Holstein-Friesian dairy cows consuming a grass silage-based diet over an 83-d period. Two groups of 39 cows were stratified for age, parity, historical milk yield and days in milk (DIM), and offered one of two treatment diets. The first treatment (CON) reflected a typical diet used by Western Australian dairy producers in summer and comprised (kg DM/cow per d); 8 kg of annual ryegrass silage, 6 kg of crushed wheat (provided once daily in a mixed ration), 3·6 kg of crushed lupins (provided in the milking parlour in two daily portions) and ad libitum lucerne haylage. The second treatment diet (COMP) was identical except the 6 kg of crushed wheat was replaced by 6 kg of a more complex concentrate mix (27% crushed wheat, 34% maize grain and 37% canola meal). Lucerne haylage was provided independently in the paddock to all cows, and no pasture was available throughout the experiment. The COMP group had a greater mean overall daily intake (22·5 vs 20·4 kg DM/cow) and a higher energy corrected milk (ECM) yield (29·2 vs 27·1 kg/cow; P = 0·047) than the CON cows. The difference in overall intake was caused by a higher daily intake of lucerne haylage in COMP cows (4·5 vs 2·3 kg DM/cow). The CON group had a higher concentration of milk fat (42·1 vs 39·3 g/kg; P = 0·029) than COMP cows. Milk protein yield was greater in COMP cows (P < 0·021); however, milk fat yield was unaffected by treatment. It is concluded that partially replacing wheat with canola meal and maize grain in a grass silage-based diet increases voluntary DMI of conserved forage and consequently yields of ECM and milk protein.

A computerized clinical decision support system as a means of implementing depression guidelines.

PubMed

Trivedi, Madhukar H; Kern, Janet K; Grannemann, Bruce D; Altshuler, Kenneth Z; Sunderajan, Prabha

2004-08-01

The authors describe the history and current use of computerized systems for implementing treatment guidelines in general medicine as well as the development, testing, and early use of a computerized decision support system for depression treatment among "real-world" clinical settings in Texas. In 1999 health care experts from Europe and the United States met to confront the well-documented challenges of implementing treatment guidelines and to identify strategies for improvement. They suggested the integration of guidelines into computer systems that is incorporated into clinical workflow. Several studies have demonstrated improvements in physicians' adherence to guidelines when such guidelines are provided in a computerized format. Although computerized decision support systems are being used in many areas of medicine and have demonstrated improved patient outcomes, their use in psychiatric illness is limited. The authors designed and developed a computerized decision support system for the treatment of major depressive disorder by using evidence-based guidelines, transferring the knowledge gained from the Texas Medication Algorithm Project (TMAP). This computerized decision support system (CompTMAP) provides support in diagnosis, treatment, follow-up, and preventive care and can be incorporated into the clinical setting. CompTMAP has gone through extensive testing to ensure accuracy and reliability. Physician surveys have indicated a positive response to CompTMAP, although the sample was insufficient for statistical testing. CompTMAP is part of a new era of comprehensive computerized decision support systems that take advantage of advances in automation and provide more complete clinical support to physicians in clinical practice.

Hexagonal boron nitride as a tablet lubricant and a comparison with conventional lubricants.

PubMed

Uğurlu, Timuçin; Turkoğlu, Murat

2008-04-02

The objective of this study was to investigate the lubrication properties of hexagonal boron nitride (HBN) as a new tablet lubricant and compare it with conventional lubricants such as magnesium stearate (MGST), stearic acid (STAC), and glyceryl behenate (COMP). Tablets were manufactured on an instrumented single-station tablet press to monitor lower punch ejection force (LPEF) containing varied lubricants in different ratio (0.5, 1, 2%). Tablet crushing strength, disintegration time and thickness were measured. Tensile strength of compacted tablets were measured by applying a diametrical load across the edge of tablets to determine mechanical strength. The deformation mechanism of tablets was studied during compression from the Heckel plots with or without lubricants. MGST was found to be the most effective lubricant based on LPEF-lubrication concentration profile and LPEF of HBN was found very close to that of MGST. HBN was better than both STAC and COMP. A good lubrication was obtained at 0.5% for MGST and HBN (189 and 195N, respectively). Where COMP and STAC showed 20 and 35% more LPEF compare to that of MGST (239 and 288N, respectively). Even at the concentration of 2% COMP and STAC did not decrease LPEF as much as 0.5% of MGST and HBN. Like all conventional lubricants the higher the concentration of HBN the lower the mechanical properties of tablets because of its hydrophobic character. However, this deterioration was not as pronounced as MGST. HBN had no significant effect on tablet properties. Based on the Heckel plots, it was observed that after the addition of 1% lubricant granules showed less plastic deformation.

Integrated rheology model: Explosive Composition B-3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, Stephen M.; Zerkle, David K.; Smilowitz, Laura B.

Composition B-3 (Comp B-3) is a high explosive formulation composed of 60/40wt% RDX (1,3,5-trinitroperhydro-1,3,5-triazine) /TNT (2,4,6 trinitrotoluene). Above approximately 78°C this formulation partially melts to form a multiphase system with solid RDX particles in a molten TNT matrix. This multiphase system presents a number of phenomena that influence its apparent viscosity. In an earlier study explosive Composition B-3 (Comp B-3, 60/40wt% RDX/TNT) was examined for evidence of yield stress using a non-isothermal falling ball viscometer and a yield stress model was proposed in this paper. An integrated viscosity model suitable for use in computational fluid dynamics (CFD) simulations is developedmore » to capture the transition from a heterogeneous solid to a Bingham viscoplastic fluid. This viscosity model is used to simulate the motion of imbedded spheres falling through molten Comp B-3. Finally, comparison of the simulations to physical tests show agreement between the positions predicted by the model and the measured locations of the spheres as a function of temperature between 90C and 165C.« less

Treatment outcomes in 3 modes of orthodontic practice.

PubMed

Poulton, Donald R; Baumrind, Sheldon; Vlaskalic, Vicki

2002-02-01

This study examined differences in pretreatment severity and treatment outcome among orthodontic patients treated in 3 different practice-management modes. Samples of pretreatment (T1) and end of treatment (T2) study casts were selected from traditional private practices (TPP, 3 offices, 81 cases), a dental corporation (COMP, 2 offices, 53 cases), and a dental management service organization (DMSO, 1 office, 36 cases). Orthodontic specialists had treated all patients. Cases were initially selected on a consecutive start basis. From each practice, the first 30 cases satisfying the study criteria were included in the sample. The T1 and T2 study casts were evaluated with the PAR and HLD indexes. The PAR and HLD indexes showed a high level of agreement on T1 cast scores but not on the T2 casts. Mean T1 scores were highest in the COMP cases, followed by the DMSO and the TPP cases. T2 scores were lowest in the TPP cases, followed by the DMSO and the COMP cases. The percentage of PAR score reduction showed that, in all 3 modes, patients were treated to a high standard.

One dimensional shock Initiation of UK Comp B

NASA Astrophysics Data System (ADS)

Burns, Malcolm

2017-06-01

Ten shock initiation experiments have been carried out on the UK isostatically pressed Composition B (59.5% RDX, 39.5% TNT, 1% wax) comprising of seven sustained pulse experiments with input pressures ranging from 2.89 to 9.86 GPa and three short shock experiments using the embedded gauge technique at the Los Alamos National Laboratory gas gun facility. The evolution of the reactive growth at and behind the shock front has been measured along with the run to detonation distance. These data have been used to create the Pop plot and hugoniot states for the UK Comp B. The shock initiation behavior of the UK Comp B has been compared to that of the equivalent US Composition. The reactive growth shows a feature that was observed in the US composition in which the wave profiles dispay a high level of pre-detonation noise. This was hypothesized to be due to a piezoelectric effect in the RDX crystals. The results of these experiments have shown that this effect may be localized in the gamma phase at shock pressures in the region of 5 GP and above.

Further evidence for addition and numerical competence by a Grey parrot (Psittacus erithacus).

PubMed

Pepperberg, Irene M

2012-07-01

A Grey parrot (Psittacus erithacus), able to quantify sets of eight or fewer items (including heterogeneous subsets), to sum two sequentially presented sets of 0–6 items (up to 6), and to identify and serially order Arabic numerals (1–8), all by using English labels (Pepperberg in J Comp Psychol 108:36–44, 1994; J CompPsychol 120:1–11, 2006a; J Comp Psychol 120:205–216,2006b; Pepperberg and Carey submitted), was tested on addition of two Arabic numerals or three sequentially presented collections (e.g., of variously sized jelly beans or nuts). He was, without explicit training and in the absence of the previously viewed addends, asked, "How many total?" and required to answer with a vocal English number label. In a few trials on the Arabic numeral addition, he was also shown variously colored Arabic numerals while the addends were hidden and asked "What color number (is the) total?" Although his death precluded testing on all possible arrays, his accuracy was statistically significant and suggested addition abilities comparable with those of nonhuman primates.

Neonatal abstinence syndrome: Neurobehavior at 6 weeks of age in infants with or without pharmacological treatment for withdrawal.

PubMed

Heller, Nicole A; Logan, Beth A; Morrison, Deborah G; Paul, Jonathan A; Brown, Mark S; Hayes, Marie J

2017-07-01

Use and abuse of prescription opioids and concomitant increase in Neonatal Abstinence Syndrome (NAS), a condition that may lead to protracted pharmacological treatment in more than 60% of infants, has tripled since 2000. This study assessed neurobehavioral development using the NICU Network Neurobehavioral Scale in 6-week old infants with prenatal methadone exposure who did (NAS+; n = 23) or did not (NAS-; n = 16) require pharmacological treatment for NAS severity determined by Finnegan Scale. An unexposed, demographically similar group of infants matched for age served as comparison (COMP; n = 21). NAS+, but not NAS- group, had significantly lower scores on the regulation (p < .01) and quality of movement (p < .01) summary scales than the COMP group. The NAS+ and NAS- groups had higher scores on the stress-abstinence scale than the COMP group (p < .05). NAS diagnosis (NAS +) was associated with poorer regulation and quality of movement at 6 weeks of age compared to infants without prenatal methadone exposure from the same demographic. © 2017 Wiley Periodicals, Inc.

Integrated rheology model: Explosive Composition B-3

DOE PAGES

Davis, Stephen M.; Zerkle, David K.; Smilowitz, Laura B.; ...

2018-03-20

Composition B-3 (Comp B-3) is a high explosive formulation composed of 60/40wt% RDX (1,3,5-trinitroperhydro-1,3,5-triazine) /TNT (2,4,6 trinitrotoluene). Above approximately 78°C this formulation partially melts to form a multiphase system with solid RDX particles in a molten TNT matrix. This multiphase system presents a number of phenomena that influence its apparent viscosity. In an earlier study explosive Composition B-3 (Comp B-3, 60/40wt% RDX/TNT) was examined for evidence of yield stress using a non-isothermal falling ball viscometer and a yield stress model was proposed in this paper. An integrated viscosity model suitable for use in computational fluid dynamics (CFD) simulations is developedmore » to capture the transition from a heterogeneous solid to a Bingham viscoplastic fluid. This viscosity model is used to simulate the motion of imbedded spheres falling through molten Comp B-3. Finally, comparison of the simulations to physical tests show agreement between the positions predicted by the model and the measured locations of the spheres as a function of temperature between 90C and 165C.« less

Phenomenon of Energy Focusing in Explosive Systems which include High Modulus Elastic Elements

NASA Astrophysics Data System (ADS)

Balagansky, I.; Hokamoto, K.; Manikandan, P.; Matrosov, A.; Stadnichenko, I.; Miyoshi, H.

2009-06-01

The phenomenon was observed in a passive HE charge of cast Comp. B without cumulative shape under shock wave loading by explosion of an active HE charge through water after preliminary compression by a leading wave in silicon carbide insert. The phenomenon manifested itself as a hole in identification steel specimen with depth of about 10 mm and diameter of about 5 mm. Results of experiments on studying of conditions of implementation of this phenomenon for SEP and Comp. B are presented. For each HE a number of experiments has been executed at various length of silicon carbide insert. Presence or absence of a hole in the steel specimen was determined. Also a number of optical registrations of process in framing mode with record step of 1 μs have been executed. Digital video camera SHIMADZU HPV-1 was used for optical registration. Results of experiments testify that the phenomenon is reproduced both for SEP, and for Comp. B. Focusing process is observed in conditions close to critical conditions of transfer of a detonation from active to a passive HE charge.

Post-Deployment Reintegration Experiences of AF Personnel: Implications for Scale Development

DTIC Science & Technology

2006-09-01

peuvent également présenter des avantages, notamment une amélioration aux points de vue suivants : confiance en soi , tolérance à l’égard de soi...notamment une amélioration aux points de vue suivants : confiance en soi , tolérance à l’égard de soi, compréhension politique et compétence militaire... confiance en soi , tolérance à l’égard de soi, compréhension politique et compétence militaire. À ce jour, les études sur l’expérience de réinsertion

Logistics Complete Round Charts: Grenades, Mines, Pyrotechnics, Rockets, Rocket Motors, Demolition Material

DTIC Science & Technology

1986-06-01

Flash 3. (342 g) Electrically Comp Actuated By Blasting Machine or Battery 5/ 8 STD 37524 Simulator, Projectile M1lSA2 0.30 7549246 MIL-S-10058 Hand...8799710 Blastin Comp (0.07 oz) Blasting (Whistle) Fuze Fuze 8-14 Frictio Friction (Burst) ’ l3AI M3A1 721 Igniter 8833721 Igniter last 5-10 8799714...8799715 iBlasti Blasting Sec FuzeN Fuze M3A1 •721 Igniter 8833721 Igniter Inst 6-10 8799714 879971 Blast Blasting See Fuze Puze N13A1 587 FrictLi 8848587

A Database Design for the Brazilian Air Force Military Personnel Control System.

DTIC Science & Technology

1987-06-01

GIVEN A RECNum GET MOVING HISTORICAL". 77 SEL4 PlC X(70) VALUE ". 4. GIVEN A RECNUM GET NOMINATION HISTORICAL". 77 SEL5 PIC X(70) VALUE it 5. GIVEN A...WHERE - "°RECNUM = :RECNUM". 77 SQL-SEL3-LENGTH PIC S9999 VALUE 150 COMP. 77 SQL- SEL4 PIC X(150) VALUE "SELECT ABBREV,DTNOM,DTEXO,SITN FROM...NOMINATION WHERE RECNUM 77 SQL- SEL4 -LENGTH PIC S9999 VALUE 150 COMP. 77 SQL-SEL5 PIC X(150) VALUE "SELECT ABBREVDTDES,DTWAIVER,SITD FROM DESIG WHERE RECNUM It

Comparisons of Buckling Capacity Curves of Pressurized Spheres with EDR Provisions and Experimental Results

NASA Astrophysics Data System (ADS)

Błażejewski, Paweł; Marcinowski, Jakub

2017-06-01

Existing provisions leading to the assessment of the buckling resistance of pressurised spherical shells were published in the European Design Recommendations (EDR) [1]. This book comprises rules which refer to the stability of steel shells of different shapes. In the first step of the general procedure they require calculation of two reference quantities: the elastic critical buckling reference pRcr and the plastic reference resistance pRpl. These quantities should be determined in the linear buckling analysis (LBA) and in the materially nonlinear analysis (MNA) respectively. Only in the case of spherical shells the existing procedure has exceptional character. It is based on the geometrically nonlinear analysis (GNA) and on the geometrically and materially nonlinear analysis (GMNA), respectively. From this reason, in this particular case there was a need to change the existing approach. The new procedure was presented in the work of Błażejewski & Marcinowski in 2016 (comp. [2]). All steps of the procedure leading to the assessment of buckling resistance of pressurized steel, spherical shells were presented in this work. The elaborated procedure is consistent with provisions of Eurocode EN1993-1-6 (comp. [3]) and with recommendations inserted in Europeans Design Recommendations [1]. The proposed capacity curves were compared with existing proposal published in [1] for three different fabrication quality classes predicted in [3]. In this work also comparisons of author's proposals with experimental results obtained by other authors were presented.

QualComp: a new lossy compressor for quality scores based on rate distortion theory

PubMed Central

2013-01-01

Background Next Generation Sequencing technologies have revolutionized many fields in biology by reducing the time and cost required for sequencing. As a result, large amounts of sequencing data are being generated. A typical sequencing data file may occupy tens or even hundreds of gigabytes of disk space, prohibitively large for many users. This data consists of both the nucleotide sequences and per-base quality scores that indicate the level of confidence in the readout of these sequences. Quality scores account for about half of the required disk space in the commonly used FASTQ format (before compression), and therefore the compression of the quality scores can significantly reduce storage requirements and speed up analysis and transmission of sequencing data. Results In this paper, we present a new scheme for the lossy compression of the quality scores, to address the problem of storage. Our framework allows the user to specify the rate (bits per quality score) prior to compression, independent of the data to be compressed. Our algorithm can work at any rate, unlike other lossy compression algorithms. We envisage our algorithm as being part of a more general compression scheme that works with the entire FASTQ file. Numerical experiments show that we can achieve a better mean squared error (MSE) for small rates (bits per quality score) than other lossy compression schemes. For the organism PhiX, whose assembled genome is known and assumed to be correct, we show that it is possible to achieve a significant reduction in size with little compromise in performance on downstream applications (e.g., alignment). Conclusions QualComp is an open source software package, written in C and freely available for download at https://sourceforge.net/projects/qualcomp. PMID:23758828

Predictive Engineering Tools for Injection-Molded Long-Carbon-Fiber Thermoplastic Composites. Topical Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, Ba Nghiep; Fifield, Leonard S.; Wang, Jin

2016-06-01

This project aimed to integrate, optimize, and validate the fiber orientation and length distribution models previously developed and implemented in the Autodesk® Simulation Moldflow® Insight (ASMI) software package for injection-molded long-carbon-fiber (LCF) thermoplastic composite structures. The project was organized into two phases. Phase 1 demonstrated the ability of the advanced ASMI package to predict fiber orientation and length distributions in LCF/polypropylene (PP) and LCF/polyamide-6, 6 (PA66) plaques within 15% of experimental results. Phase 2 validated the advanced ASMI package by predicting fiber orientation and length distributions within 15% of experimental results for a complex three-dimensional (3D) Toyota automotive part injection-moldedmore » from LCF/PP and LCF/PA66 materials. Work under Phase 2 also included estimate of weight savings and cost impacts for a vehicle system using ASMI and structural analyses of the complex part. The present report summarizes the completion of Phases 1 and 2 work activities and accomplishments achieved by the team comprising Pacific Northwest National Laboratory (PNNL); Purdue University (Purdue); Virginia Polytechnic Institute and State University (Virginia Tech); Autodesk, Inc. (Autodesk); PlastiComp, Inc. (PlastiComp); Toyota Research Institute North America (Toyota); Magna Exteriors and Interiors Corp. (Magna); and University of Illinois. Figure 1 illustrates the technical approach adopted in this project that progressed from compounding LCF/PP and LCF/PA66 materials, to process model improvement and implementation, to molding and modeling LCF/PP and LCF/PA66 plaques. The lessons learned from the plaque study and the successful validation of improved process models for fiber orientation and length distributions for these plaques enabled the project to go to Phase 2 to mold, model, and optimize the 3D complex part.« less

Connections of the Auditory Brainstem in a Songbird, Taeniopygia guttata. II. Projections of Nucleus Angularis and Nucleus Laminaris to the Superior Olive and Lateral Lemniscal Nuclei

PubMed Central

Krützfeldt, Nils O.E.; Logerot, Priscilla; Kubke, M. Fabiana; Wild, J. Martin

2013-01-01

Three nuclei of the lateral lemniscus are present in the zebra finch, ventral (LLV), intermediate (LLI), and dorsal (LLD). LLV is separate from the superior olive (OS): it lies closer to the spinal lemniscus and extends much further rostrally around the pontine periphery. LLI extends from a caudal position ventrolateral to the principal sensory trigeminal nucleus (LLIc) to a rostral position medial to the ventrolateral parabrachial nucleus (LLIr). LLD consists of posterior (LLDp) and anterior (LLDa) parts, which are largely coextensive rostrocaudally, although LLDa lies medial to LLDp. All nuclei are identifiable on the basis of cytochrome oxidase activity. The cochlear nucleus angularis (NA) and the third-order nucleus laminaris (NL) project on OS predominantly ipsilaterally, on LLV and LLI predominantly contralaterally, and on LLD contralaterally only. The NA projections are heavier than those of NL and differ from them primarily in their terminations within LLD: NA projects to LLDp, whereas NL projects to LLDa. In this the projections are similar to those in the barn owl (Takahashi and Konishi [1988] J Comp Neurol 274:212–238), in which time and intensity pathways remain separate as far as the central nucleus of the inferior colliculus (MLd). In contrast, in the zebra finch, although NA and NL projections remain separate within LLD, the projections of LLDa and LLDp become intermixed within MLd (Wild et al., J Comp Neurol, this issue), consistent with the intermixing of the direct NA and NL projections to MLd (Krützfeldt et al., J Comp Neurol, this issue). J. Comp. Neurol. 518:2135–2148, 2010. PMID:20394062

Inflammation is more distinct in temporomandibular joint osteoarthritis compared to the knee joint.

PubMed

Vos, Lukas M; Kuijer, Roel; Huddleston Slater, James J R; Bulstra, Sjoerd K; Stegenga, Boudewijn

2014-01-01

Most of the current understanding of articular cartilage maintenance and degradation is derived from large load-bearing synovial joints, in particular the knee joint. The aim of this study was to identify valuable degradation markers for cartilage degradation in the temporomandibular joint (TMJ) by comparing the relative concentrations of carboxyterminal telopeptides of collagen types I and II (CTX-I and CTX-II), cartilage oligomeric matrix protein (COMP), and prostaglandin E2 (PGE2) in synovial fluid (SF) of TMJ and knee joints with cartilage degradation. In this cross-sectional comparative study, participants were recruited from the University Medical Center Groningen, The Netherlands. Patients with TMJ osteoarthritis were compared with patients with knee osteoarthritis. The outcome variables were the relative SF concentrations of CTX-I, CTX-II, COMP, and PGE2. An independent samples Mann-Whitney U test was used to compare the relative concentrations. Thirty consecutive patients (9 male, 21 female; mean age, 40.1 yr; standard deviation, 15.3 yr) with TMJ osteoarthritis and 31 consecutive patients (20 male, 11 female; mean age, 37.4 yr; standard deviation, 13.7 yr) who were scheduled for arthroscopy of the knee joint participated in this study. Significant differences were found between relative concentrations of COMP (P = .000) and PGE2 (P = .005), and no significant differences were found between relative concentrations of CTX-I (P = .720) and CTX-II (P = .242). Relative SF concentrations of COMP and PGE2 showed significant differences between the TMJ and the knee joint, suggesting that there are differences in pathophysiology and that the inflammatory component may be more distinct in the TMJ. Copyright © 2014 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

Evaluation of Real-Time and Off-Line Performance of the Virtual Seismologist Earthquake Early Warning Algorithm in Switzerland

NASA Astrophysics Data System (ADS)

Behr, Yannik; Clinton, John; Cua, Georgia; Cauzzi, Carlo; Heimers, Stefan; Kästli, Philipp; Becker, Jan; Heaton, Thomas

2013-04-01

The Virtual Seismologist (VS) method is a Bayesian approach to regional network-based earthquake early warning (EEW) originally formulated by Cua and Heaton (2007). Implementation of VS into real-time EEW codes has been an on-going effort of the Swiss Seismological Service at ETH Zürich since 2006, with support from ETH Zürich, various European projects, and the United States Geological Survey (USGS). VS is one of three EEW algorithms that form the basis of the California Integrated Seismic Network (CISN) ShakeAlert system, a USGS-funded prototype end-to-end EEW system that could potentially be implemented in California. In Europe, VS is currently operating as a real-time test system in Switzerland. As part of the on-going EU project REAKT (Strategies and Tools for Real-Time Earthquake Risk Reduction), VS installations in southern Italy, western Greece, Istanbul, Romania, and Iceland are planned or underway. In Switzerland, VS has been running in real-time on stations monitored by the Swiss Seismological Service (including stations from Austria, France, Germany, and Italy) since 2010. While originally based on the Earthworm system it has recently been ported to the SeisComp3 system. Besides taking advantage of SeisComp3's picking and phase association capabilities it greatly simplifies the potential installation of VS at networks in particular those already running SeisComp3. We present the architecture of the new SeisComp3 based version and compare its results from off-line tests with the real-time performance of VS in Switzerland over the past two years. We further show that the empirical relationships used by VS to estimate magnitudes and ground motion, originally derived from southern California data, perform well in Switzerland.

Melt Infiltrated Ceramic Matrix Composites for Shrouds and Combustor Liners of Advanced Industrial Gas Turbines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gregory Corman; Krishan Luthra; Jill Jonkowski

2011-01-07

This report covers work performed under the Advanced Materials for Advanced Industrial Gas Turbines (AMAIGT) program by GE Global Research and its collaborators from 2000 through 2010. A first stage shroud for a 7FA-class gas turbine engine utilizing HiPerComp{reg_sign}* ceramic matrix composite (CMC) material was developed. The design, fabrication, rig testing and engine testing of this shroud system are described. Through two field engine tests, the latter of which is still in progress at a Jacksonville Electric Authority generating station, the robustness of the CMC material and the shroud system in general were demonstrated, with shrouds having accumulated nearly 7,000more » hours of field engine testing at the conclusion of the program. During the latter test the engine performance benefits from utilizing CMC shrouds were verified. Similar development of a CMC combustor liner design for a 7FA-class engine is also described. The feasibility of using the HiPerComp{reg_sign} CMC material for combustor liner applications was demonstrated in a Solar Turbines Ceramic Stationary Gas Turbine (CSGT) engine test where the liner performed without incident for 12,822 hours. The deposition processes for applying environmental barrier coatings to the CMC components were also developed, and the performance of the coatings in the rig and engine tests is described.« less

HNS/Teflon, a new heat resistant explosive

NASA Technical Reports Server (NTRS)

Heller, H.; Bertram, A. L.

1973-01-01

HNS/Teflon (90/10) is a new pressed explosive developed for use in the Apollo program. The major advantages of HNS/Teflon are (1) excellent thermal stability at elevated temperatures, (2) superior resistance to sublimation at high temperatures and low pressures and (3) ease of molding powder preparation, pressing and machining. The impact sensitivity of HNS/Teflon is between that of Comp B and Comp A-3 while its explosive performance is about the same as TNT. Under the severe environmental conditions of the moon's surface, this explosive successfully performed its intended function of generating seismic waves in the Apollo ALSEP and LSPE experiments. (Modified author abstract)

CompGC: Efficient Offline/Online Semi-Honest Two-Party Computation

DTIC Science & Technology

2017-02-03

κ ∈ N : Pr [ ExptprivA,S(κ) = 1 ] ≤ 1 2 + µ(κ) 4.1. Component-Based Secure Two-Party Compu- tation We now briefly describe how to use component-based...number of classes and “F” is the number of features. Specs. Naive CompGC Bost et al. [BPTG15] Data Set N D Time Time* Comm. Time Time* Comm. Time Comm...Rounds Nursery 4 4 40 0.3 40 0.01 2085 21.6 15 ECG 6 4 40 0.4 40 0.1 8816 29.1 22 (c) Decision tree classifier. “ N ” is the number of internal nodes in

Novel peptide chemistry in terrestrial animals: natural luciferin analogues from the bioluminescent earthworm Fridericia heliota.

PubMed

Dubinnyi, Maxim A; Tsarkova, Aleksandra S; Petushkov, Valentin N; Kaskova, Zinaida M; Rodionova, Natalja S; Kovalchuk, Sergey I; Ziganshin, Rustam H; Baranov, Mikhail S; Mineev, Konstantin S; Yampolsky, Ilia V

2015-03-02

We report isolation and structure elucidation of AsLn5, AsLn7, AsLn11 and AsLn12: novel luciferin analogs from the bioluminescent earthworm Fridericia heliota. They were found to be highly unusual modified peptides, comprising either of the two tyrosine-derived chromophores, CompX or CompY and a set of amino acids, including threonine, gamma-aminobutyric acid, homoarginine, and unsymmetrical N,N-dimethylarginine. These natural compounds represent a unique peptide chemistry found in terrestrial animals and rise novel questions concerning their biosynthetic origin. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

GlycCompSoft: Software for Automated Comparison of Low Molecular Weight Heparins Using Top-Down LC/MS Data

PubMed Central

Li, Lingyun; Zhang, Fuming; Hu, Min; Ren, Fuji; Chi, Lianli; Linhardt, Robert J.

2016-01-01

Low molecular weight heparins are complex polycomponent drugs that have recently become amenable to top-down analysis using liquid chromatography-mass spectrometry. Even using open source deconvolution software, DeconTools, and automatic structural assignment software, GlycReSoft, the comparison of two or more low molecular weight heparins is extremely time-consuming, taking about a week for an expert analyst and provides no guarantee of accuracy. Efficient data processing tools are required to improve analysis. This study uses the programming language of Microsoft Excel™ Visual Basic for Applications to extend its standard functionality for macro functions and specific mathematical modules for mass spectrometric data processing. The program developed enables the comparison of top-down analytical glycomics data on two or more low molecular weight heparins. The current study describes a new program, GlycCompSoft, which has a low error rate with good time efficiency in the automatic processing of large data sets. The experimental results based on three lots of Lovenox®, Clexane® and three generic enoxaparin samples show that the run time of GlycCompSoft decreases from 11 to 2 seconds when the data processed decreases from 18000 to 1500 rows. PMID:27942011

Predictive Engineering Tools for Injection-Molded Long-Carbon-Fiber Thermoplastic Composites - FY 2014 Fourth Quarterly Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, Ba Nghiep; Fifield, Leonard S.; Mathur, Raj N.

2014-09-30

During the last quarter of FY 2014, the following technical progress has been made toward project milestones: 1) Autodesk, Inc. (Autodesk) has implemented a new fiber length distribution (FLD) model based on an unbreakable length assumption with Reduced Order Modeling (ROM) by the Proper Orthogonal Decomposition (POD) approach in the mid-plane, dual-domain and 3D solvers. 2) Autodesk improved the ASMI 3D solver for fiber orientation prediction using the anisotropic rotary diffusion (ARD) – reduced strain closure (RSC) model. 3) Autodesk received consultant services from Prof. C.L. Tucker at the University of Illinois on numerical simulation of fiber orientation and fibermore » length. 4) PlastiComp, Inc. (PlastiComp) suggested to Purdue University a procedure for fiber separation using an inert-gas atmosphere in the burn-off furnace. 5) Purdue University (Purdue) hosted a face-to-face project review meeting at Purdue University on August 6-7, 2014. 6) Purdue conducted fiber orientation measurements for 3 PlastiComp plaques: fast-fill 30wt% LCF/PP edged-gated, slow-fill 50wt% LCF/PP edge-gated, and slow-fill 50wt% LCF/PP center-gated plaques, and delivered the orientation data for these plaques at the selected locations (named A, B, and C) to PNNL. 7) PNNL conducted ASMI mid-plane analyses for the above PlastiComp plaques and compared the predicted fiber orientations with the measured data provided by Purdue at Locations A, B, and C on these plaques. 8) PNNL planned the project review meeting (August 6-7, 2014) with Purdue. 9) PNNL performed ASMI analyses for the Toyota complex parts with and without ribs, having different wall thicknesses, and using the PlastiComp 50wt% LCF/PP, 50wt% LCF/PA66, 30wt% LCF/PP, and 30wt% LCF/PA66 materials to provide guidance for tool design and modifications needed for molding these parts. 10) Magna Exteriors and Interiors Corp. (Magna) molded plaques from the 50% LCF/PP and 50% LCF/PA66 materials received from Plasticomp in order to extract machine purgings (purge materials) from Magna’s 200-Ton Injection Molding machine targeted to mold the complex part. 11) Toyota and Magna discussed with PNNL tool modification for molding the complex part.« less

A comparison of hydrostatic weighing and air displacement plethysmography in adults with spinal cord injury.

PubMed

Clasey, Jody L; Gater, David R

2005-11-01

To compare (1) total body volume (V(b)) and density (D(b)) measurements obtained by hydrostatic weighing (HW) and air displacement plethysmography (ADP) in adults with spinal cord injury (SCI); (2) measured and predicted thoracic gas volume (V(TG)); and (3) differences in percentage of fat measurements using ADP-obtained D(b) and HW-obtained D(b) measures that were interchanged in a 4-compartment body composition model (4-comp %fat). Twenty adults with SCI underwent ADP and V(TG), and HW testing. In a subgroup (n=13) of subjects, 4-comp %fat procedures were computed. Research laboratories in a university setting. Twenty adults with SCI below the T3 vertebrae and motor complete paraplegia. Not applicable. Statistical analyses, including determination of group mean differences, shared variance, total error, and 95% confidence intervals. The 2 methods yielded small yet significantly different V(b) and D(b). The groups' mean V(TG) did not differ significantly, but the large relative differences indicated an unacceptable amount of individual error. When the 4-comp %fat measurements were compared, there was a trend toward significant differences (P=.08). ADP is a valid alternative method of determining the V(b) and D(b) in adults with SCI; however, the predicted V(TG) should be used with caution.

Effects of Ion-ion Collisions and Inhomogeneity in Two-dimensional Simulations of Stimulated Brillouin Backscattering*

NASA Astrophysics Data System (ADS)

Cohen, B. I.

2005-10-01

Two-dimensional simulations of stimulated Brillouin backscattering (SBBS) with the BZOHAR^1 code have been extended to include ion-ion collisions and spatial nonuniformity in the mean ion flow. BZOHAR hybrid simulations (particle-in-cell kinetic ions and Boltzmann fluid electrons) have shown^2 that SBBS saturation is dominated by ion trapping effects and secondary instability of the primary ion wave (decay into subharmonic ion waves and ion quasi-modes). Here we address the effects of ion collisions^3 on SBBS saturation and employ the efficient Langevin ion collision algorithm of Ref. 4 and the Fokker-Planck collision operator of Ref. 5. We also report simulations of SBBS with a linear gradient in the mean ion drift, which in conjunction with the nonlinear frequency shift due to ion trapping can introduce auto-resonance effects that may enhance reflectivities.^6 For SBBS in a high-gain limit with ion collisions or inhomogeneity, we find that ion trapping and secondary ion wave instabilities are robust saturation mechanisms. *Work performed for US DOE by UC LLNL under Contr. W-7405-ENG-48. ^1B.I. Cohen, et al., Phys. Plasmas 4, 956 (1997). ^2B.I. Cohen, et al., Phys. Plasmas, 12, 052703 (2005),. ^ 3P.W. Rambo, et al., Phys. Rev. Lett. 79, 83 (1997). ^ 4M.E. Jones, et al., J. Comp. Phys. 123, 169, (1996). ^ 5W. M. Manheimer, et al., J. Comp. Phys. 138, 563 (1997). ^ 6E.A. Williams, et al., Phys. Plasmas 11, 231 (2004).

Comparison of organ-at-risk sparing and plan robustness for spot-scanning proton therapy and volumetric modulated arc photon therapy in head-and-neck cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barten, Danique L. J., E-mail: d.barten@vumc.nl; Tol, Jim P.; Dahele, Max

Purpose: Proton radiotherapy for head-and-neck cancer (HNC) aims to improve organ-at-risk (OAR) sparing over photon radiotherapy. However, it may be less robust for setup and range uncertainties. The authors investigated OAR sparing and plan robustness for spot-scanning proton planning techniques and compared these with volumetric modulated arc therapy (VMAT) photon plans. Methods: Ten HNC patients were replanned using two arc VMAT (RapidArc) and spot-scanning proton techniques. OARs to be spared included the contra- and ipsilateral parotid and submandibular glands and individual swallowing muscles. Proton plans were made using Multifield Optimization (MFO, using three, five, and seven fields) and Single-field Optimizationmore » (SFO, using three fields). OAR sparing was evaluated using mean dose to composite salivary glands (Comp{sub Sal}) and composite swallowing muscles (Comp{sub Swal}). Plan robustness was determined for setup and range uncertainties (±3 mm for setup, ±3% HU) evaluating V95% and V107% for clinical target volumes. Results: Averaged over all patients Comp{sub Sal}/Comp{sub Swal} mean doses were lower for the three-field MFO plans (14.6/16.4 Gy) compared to the three-field SFO plans (20.0/23.7 Gy) and VMAT plans (23.0/25.3 Gy). Using more than three fields resulted in differences in OAR sparing of less than 1.5 Gy between plans. SFO plans were significantly more robust than MFO plans. VMAT plans were the most robust. Conclusions: MFO plans had improved OAR sparing but were less robust than SFO and VMAT plans, while SFO plans were more robust than MFO plans but resulted in less OAR sparing. Robustness of the MFO plans did not increase with more fields.« less

Spectrophotometric determination of cyclotrimethylenetrinitramine (RDX) in explosive mixtures and residues with the Berthelot reaction.

PubMed

Uzer, A; Erçağ, E; Apak, R

2008-03-31

On-site colorimetric methods are a valuable, cost-effective tool to assess the nature and extent of contamination in remediated sites and to enable on-site screening for police criminology laboratories. The existing colorimetric method for cyclotrimethylenetrinitramine (RDX) based on a Griess reaction suffers from the non-quantitative reduction to nitrite and from the unstable character of HNO2 in acidic medium. Thus we propose a novel spectrophotometric RDX assay in explosive mixtures and residues, based on (Zn+HCl) reduction of RDX in a microwave oven, followed by neutralization of the reduction products to ammonia and low molecular-weight amines, and Berthelot reaction of these amine-compounds with phenol and hypochlorite in alkaline medium to give an intensely blue indophenol dye absorbing at 631nm. The molar absorptivity and limit of detection (LOD) for RDX were (1.08+/-0.04)x10(4) L mol(-1) cm(-1) and 0.18 mg L(-1), respectively. Application of the method to synthetic mixture solutions of RDX and trinitrotoluene (TNT) at varying proportions showed that there was minimal interference from TNT (which could be compensated for by dicyclohexylamine colorimetry), since the Berthelot reaction was essentially non-responsive to m-substituted anilines derived from TNT upon (Zn+HCl) reduction. The proposed method was successfully applied to military-purpose explosive mixtures of (RDX+inert matter) such as Comp A5, Comp C4, and Hexal P30, and to (RDX+TNT) mixtures such as Comp B. The molar absorptivity of RDX was much higher than that of either ammonium or nitrate; RDX could be effectively separated from ammonium and nitrate in soil mixtures, based on solubility differences. The Berthelot method for RDX was statistically validated using Comp B mixtures against standard HPLC equipped with a Hypersil C-18 column with (40% MeOH-60% H2O) mobile phase, and against gas chromatography-thermal energy analysis (GC-TEA) system.

Effect of lower limb compression on blood flow and performance in elite wheelchair rugby athletes

PubMed Central

Vaile, Joanna; Stefanovic, Brad; Askew, Christopher D.

2016-01-01

Objective To investigate the effects of compression socks worn during exercise on performance and physiological responses in elite wheelchair rugby athletes. Design In a non-blinded randomized crossover design, participants completed two exercise trials (4 × 8 min bouts of submaximal exercise, each finishing with a timed maximal sprint) separated by 24 hr, with or without compression socks. Setting National Sports Training Centre, Queensland, Australia. Participants Ten national representative male wheelchair rugby athletes with cervical spinal cord injuries volunteered to participate. Interventions Participants wore medical grade compression socks on both legs during the exercise task (COMP), and during the control trial no compression was worn (CON). Outcome Measures The efficacy of the compression socks was determined by assessments of limb blood flow, core body temperature, heart rate, and ratings of perceived exertion, perceived thermal strain, and physical performance. Results While no significant differences between conditions were observed for maximal sprint time, average lap time was better maintained in COMP compared to CON (P<0.05). Lower limb blood flow increased from pre- to post-exercise by the same magnitude in both conditions (COMP: 2.51 ± 2.34; CON: 2.20 ± 1.85 ml.100 ml.−1min−1), whereas there was a greater increase in upper limb blood flow pre- to post-exercise in COMP (10.77 ± 8.24 ml.100 ml.−1min−1) compared to CON (6.21 ± 5.73 ml.100 ml.−1min−1; P < 0.05). Conclusion These findings indicate that compression socks worn during exercise is an effective intervention for maintaining submaximal performance during wheelchair exercise, and this performance benefit may be associated with an augmentation of upper limb blood flow. PMID:25582434

Mathematical foundations of the dendritic growth models.

PubMed

Villacorta, José A; Castro, Jorge; Negredo, Pilar; Avendaño, Carlos

2007-11-01

At present two growth models describe successfully the distribution of size and topological complexity in populations of dendritic trees with considerable accuracy and simplicity, the BE model (Van Pelt et al. in J. Comp. Neurol. 387:325-340, 1997) and the S model (Van Pelt and Verwer in Bull. Math. Biol. 48:197-211, 1986). This paper discusses the mathematical basis of these models and analyzes quantitatively the relationship between the BE model and the S model assumed in the literature by developing a new explicit equation describing the BES model (a dendritic growth model integrating the features of both preceding models; Van Pelt et al. in J. Comp. Neurol. 387:325-340, 1997). In numerous studies it is implicitly presupposed that the S model is conditionally linked to the BE model (Granato and Van Pelt in Brain Res. Dev. Brain Res. 142:223-227, 2003; Uylings and Van Pelt in Network 13:397-414, 2002; Van Pelt, Dityatev and Uylings in J. Comp. Neurol. 387:325-340, 1997; Van Pelt and Schierwagen in Math. Biosci. 188:147-155, 2004; Van Pelt and Uylings in Network. 13:261-281, 2002; Van Pelt, Van Ooyen and Uylings in Modeling Dendritic Geometry and the Development of Nerve Connections, pp 179, 2000). In this paper we prove the non-exactness of this assumption, quantify involved errors and determine the conditions under which the BE and S models can be separately used instead of the BES model, which is more exact but considerably more difficult to apply. This study leads to a novel expression describing the BE model in an analytical closed form, much more efficient than the traditional iterative equation (Van Pelt et al. in J. Comp. Neurol. 387:325-340, 1997) in many neuronal classes. Finally we propose a new algorithm in order to obtain the values of the parameters of the BE model when this growth model is matched to experimental data, and discuss its advantages and improvements over the more commonly used procedures.

Sports-related sudden cardiac deaths in the young population of Switzerland.

PubMed

Asatryan, Babken; Vital, Cristina; Kellerhals, Christoph; Medeiros-Domingo, Argelia; Gräni, Christoph; Trachsel, Lukas D; Schmied, Christian M; Saguner, Ardan M; Eser, Prisca; Herzig, David; Bolliger, Stephan; Michaud, Katarzyna; Wilhelm, Matthias

2017-01-01

In Switzerland, ECG screening was first recommended for national squad athletes in 1998. Since 2001 it has become mandatory in selected high-risk professional sports. Its impact on the rates of sports-related sudden cardiac death (SCD) is unknown. We aimed to study the incidence, causes and time trends of sports-related SCD in comparison to SCD unrelated to exercise in Switzerland. We reviewed all forensic reports of SCDs of the German-speaking region of Switzerland in the age group of 10 to 39 years, occurring between 1999 and 2010. Cases were classified into three categories based on whether or not deaths were associated with sports: no sports (NONE), recreational sports (REC), and competitive sports (COMP). Over the 12-year study period, 349 SCD cases were recorded (mean age 30±7 years, 76.5% male); 297 cases were categorized as NONE, 31 as REC, and 21 as COMP. Incidences of SCD per 100,000 person-years [mean (95% CI)] were the lowest in REC [0.43 (0.35-0.56)], followed by COMP [1.19 (0.89-1.60)] and NONE [2.46 (2.27-2.66)]. In all three categories, coronary artery disease (CAD) with or without acute myocardial infarction (MI) was the most common cause of SCD. Three professional athletes were identified in COMP category which all had SCD due to acute MI. There were no time trends, neither in overall, nor in cause-specific incidences of SCD. The incidence of SCD in young individuals in Switzerland is low, both related and unrelated to sports. In regions, like Switzerland, where CAD is the leading cause of SCD associated with competitions, screening for cardiovascular risk factors in addition to the current PPS recommendations might be indicated to improve detection of silent CAD and further decrease the incidence of SCD.

The Relationship of Core Strength and Activation and Performance on Three Functional Movement Screens.

PubMed

Johnson, Caleb D; Whitehead, Paul N; Pletcher, Erin R; Faherty, Mallory S; Lovalekar, Mita T; Eagle, Shawn R; Keenan, Karen A

2018-04-01

Johnson, CD, Whitehead, PN, Pletcher, ER, Faherty, MS, Lovalekar, MT, Eagle, SR, and Keenan, KA. The relationship of core strength and activation and performance on three functional movement screens. J Strength Cond Res 32(4): 1166-1173, 2018-Current measures of core stability used by clinicians and researchers suffer from several shortcomings. Three functional movement screens appear, at face-value, to be dependent on the ability to activate and control core musculature. These 3 screens may present a viable alternative to current measures of core stability. Thirty-nine subjects completed a deep squat, trunk stability push-up, and rotary stability screen. Scores on the 3 screens were summed to calculate a composite score (COMP). During the screens, muscle activity was collected to determine the length of time that the bilateral erector spinae, rectus abdominis, external oblique, and gluteus medius muscles were active. Strength was assessed for core muscles (trunk flexion and extension, trunk rotation, and hip abduction and adduction) and accessory muscles (knee flexion and extension and pectoralis major). Two ordinal logistic regression equations were calculated with COMP as the outcome variable, and: (a) core strength and accessory strength, (b) only core strength. The first model was significant in predicting COMP (p = 0.004) (Pearson's Chi-Square = 149.132, p = 0.435; Nagelkerke's R-Squared = 0.369). The second model was significant in predicting COMP (p = 0.001) (Pearson's Chi-Square = 148.837, p = 0.488; Nagelkerke's R-Squared = 0.362). The core muscles were found to be active for most screens, with percentages of "time active" for each muscle ranging from 54-86%. In conclusion, performance on the 3 screens is predicted by core strength, even when accounting for "accessory" strength variables. Furthermore, it seems the screens elicit wide-ranging activation of core muscles. Although more investigation is needed, these screens, collectively, seem to be a good assessment of core strength.

Whole blood lead levels are associated with biomarkers of joint tissue metabolism in African American and white men and women: the Johnston County Osteoarthritis Project.

PubMed

Nelson, Amanda E; Chaudhary, Sanjay; Kraus, Virginia B; Fang, Fang; Chen, Jiu-Chiuan; Schwartz, Todd A; Shi, Xiaoyan A; Renner, Jordan B; Stabler, Thomas V; Helmick, Charles G; Caldwell, Kathleen; Poole, A Robin; Jordan, Joanne M

2011-11-01

To examine associations between biomarkers of joint tissue metabolism and whole blood lead (Pb), separately for men and women in an African American and Caucasian population, which may reflect an underlying pathology. Participants in the Johnston County Osteoarthritis Project Metals Exposure Sub-Study (329 men and 342 women) underwent assessment of whole blood Pb and biochemical biomarkers of joint tissue metabolism. Urinary cross-linked N telopeptide of type I collagen (uNTX-I) and C-telopeptide fragments of type II collagen (uCTX-II), serum cleavage neoepitope of type II collagen (C2C), serum type II procollagen synthesis C-propeptide (CPII), and serum hyaluronic acid (HA) were measured using commercially available kits; the ratio of [C2C:CPII] was calculated. Serum cartilage oligomeric matrix protein (COMP) was measured by an in-house assay. Multiple linear regression models were used to examine associations between continuous blood Pb and biomarker outcomes, adjusted for age, race, current smoking status, and body mass index. Results are reported as estimated change in biomarker level for a 5-unit change in Pb level. The median Pb level among men and women was 2.2 and 1.9μg/dL, respectively. Correlations were noted between Pb levels and the biomarkers uNTX-I, uCTX-II, and COMP in women, and between Pb and uCTX-II, COMP, CPII, and the ratio [C2C:CPII] in men. In adjusted models among women, a 5-unit increase in blood Pb level was associated with a 28% increase in uCTX-II and a 45% increase in uNTX-I levels (uCTX-II: 1.28 [95% CI: 1.04-1.58], uNTX-I: 1.45 [95% CI:1.21-1.74]). Among men, levels of Pb and COMP showed a borderline positive association (8% increase in COMP for a 5-unit change in Pb: 1.08 [95% CI: 1.00-1.18]); no other associations were significant after adjustment. Based upon known biomarker origins, the novel associations between blood Pb and biomarkers appear to be primarily reflective of relationships to bone and calcified cartilage turnover among women and cartilage metabolism among men, suggesting a potential gender-specific effect of Pb on joint tissue metabolism that may be relevant to osteoarthritis. Copyright © 2011 Elsevier Inc. All rights reserved.

Whole blood lead levels are associated with biomarkers of joint tissue metabolism in African American and White men and women: The Johnston County Osteoarthritis Project

PubMed Central

Nelson, Amanda E.; Chaudhary, Sanjay; Kraus, Virginia B.; Fang, Fang; Chen, Jiu-Chiuan; Schwartz, Todd A.; Shi, Xiaoyan A.; Renner, Jordan B.; Stabler, Thomas V.; Helmick, Charles G.; Caldwell, Kathleen; Poole, A. Robin; Jordan, Joanne M.

2011-01-01

Purpose To examine associations between biomarkers of joint tissue metabolism and whole blood lead (Pb), separately for men and women in an African American and Caucasian population, which may reflect an underlying pathology. Methods Participants in the Johnston County Osteoarthritis Project Metals Exposure Sub-study (329 men and 342 women) underwent assessment of whole blood Pb and biochemical biomarkers of joint tissue metabolism. Urinary cross-linked N telopeptide of type I collagen (uNTX-I) and C-telopeptide fragments of type II collagen (uCTX-II), and serum cleavage neoepitope of type II collagen (C2C), serum type II procollagen synthesis C-propeptide (CPII), and serum hyaluronic acid (HA) were measured using commercially available kits; the ratio of [C2C:CPII] was calculated. Serum cartilage oligomeric matrix protein (COMP) was measured by an in-house assay. Multiple linear regression models were used to examine associations between continuous blood Pb and biomarker outcomes, adjusted for age, race, current smoking status, and body mass index. Results are reported as estimated change in biomarker level for a 5-unit change in Pb level. Results The median Pb level among men and women was 2.2 and 1.9 µg/dL, respectively. Correlations were noted between Pb levels and the biomarkers uNTX-I, uCTX-II, and COMP in women, and between Pb and uCTX-II, COMP, CPII, and the ratio [C2C:CPII] in men. In adjusted models among women, a 5-unit increase in blood Pb level was associated with a 28% increase in uCTX-II and a 45% increase in uNTX-I levels (uCTX-II: 1.28 [95%CI: 1.04–1.58], uNTX-I: 1.45 [95%CI:1.21–1.74]). Among men, levels of Pb and COMP showed a borderline positive association (8% increase in COMP for a 5-unit change in Pb: 1.08 [95% CI: 1.00–1.18])); no other associations were significant after adjustment. Conclusions Based upon known biomarker origins, the novel associations between blood Pb and biomarkers appear to be primarily reflective of relationships to bone and calcified cartilage turnover among women and cartilage metabolism among men, suggesting a potential gender-specific effect of Pb on joint tissue metabolism that may be relevant to osteoarthritis. PMID:21839992

Analysis of mobile fronthaul bandwidth and wireless transmission performance in split-PHY processing architecture.

PubMed

Miyamoto, Kenji; Kuwano, Shigeru; Terada, Jun; Otaka, Akihiro

2016-01-25

We analyze the mobile fronthaul (MFH) bandwidth and the wireless transmission performance in the split-PHY processing (SPP) architecture, which redefines the functional split of centralized/cloud RAN (C-RAN) while preserving high wireless coordinated multi-point (CoMP) transmission/reception performance. The SPP architecture splits the base stations (BS) functions between wireless channel coding/decoding and wireless modulation/demodulation, and employs its own CoMP joint transmission and reception schemes. Simulation results show that the SPP architecture reduces the MFH bandwidth by up to 97% from conventional C-RAN while matching the wireless bit error rate (BER) performance of conventional C-RAN in uplink joint reception with only 2-dB signal to noise ratio (SNR) penalty.

Effect of Velocity of Detonation of Explosives on Seismic Radiation

NASA Astrophysics Data System (ADS)

Stroujkova, A. F.; Leidig, M.; Bonner, J. L.

2014-12-01

We studied seismic body wave generation from four fully contained explosions of approximately the same yields (68 kg of TNT equivalent) conducted in anisotropic granite in Barre, VT. The explosions were detonated using three types of explosives with different velocities of detonation (VOD): Black Powder (BP), Ammonium Nitrate Fuel Oil/Emulsion (ANFO), and Composition B (COMP B). The main objective of the experiment was to study differences in seismic wave generation among different types of explosives, and to determine the mechanism responsible for these differences. The explosives with slow burn rate (BP) produced lower P-wave amplitude and lower corner frequency, which resulted in lower seismic efficiency (0.35%) in comparison with high burn rate explosives (2.2% for ANFO and 3% for COMP B). The seismic efficiency estimates for ANFO and COMP B agree with previous studies for nuclear explosions in granite. The body wave radiation pattern is consistent with an isotropic explosion with an added azimuthal component caused by vertical tensile fractures oriented along pre-existing micro-fracturing in the granite, although the complexities in the P- and S-wave radiation patterns suggest that more than one fracture orientation could be responsible for their generation. High S/P amplitude ratios and low P-wave amplitudes suggest that a significant fraction of the BP source mechanism can be explained by opening of the tensile fractures as a result of the slow energy release.

Promoting Optimal Physical Exercise for Life: An Exercise and Self-Management Program to Encourage Participation in Physical Activity after Discharge from Stroke Rehabilitation—A Feasibility Study

PubMed Central

Mansfield, Avril; Knorr, Svetlana; Poon, Vivien; Inness, Elizabeth L.; Middleton, Laura; Biasin, Louis; Brunton, Karen; Howe, Jo-Anne; Brooks, Dina

2016-01-01

People with stroke do not achieve adequate levels of physical exercise following discharge from rehabilitation. We developed a group exercise and self-management program (PROPEL), delivered during stroke rehabilitation, to promote uptake of physical activity after discharge. This study aimed to establish the feasibility of a larger study to evaluate the effect of this program on participation in self-directed physical activity. Participants with subacute stroke were recruited at discharge from one of three rehabilitation hospitals; one hospital offered the PROPEL program whereas the other two did not (comparison group; COMP). A high proportion (11/16) of eligible PROPEL program participants consented to the study. Fifteen COMP participants were also recruited. Compliance with wearing an accelerometer for 6 weeks continuously and completing physical activity questionnaires was high (>80%), whereas only 34% of daily heart rate data were available. Individuals who completed the PROPEL program seemed to have higher outcome expectations for exercise, fewer barriers to physical activity, and higher participation in physical activity than COMP participants (Hedge's g ≥ 0.5). The PROPEL program delivered during stroke rehabilitation shows promise for reducing barriers to exercise and increasing participation in physical activity after discharge. This study supports feasibility of a larger randomized trial to evaluate this program. PMID:27313948

A 3-D Approach for Teaching and Learning about Surface Water Systems through Computational Thinking, Data Visualization and Physical Models

NASA Astrophysics Data System (ADS)

Caplan, B.; Morrison, A.; Moore, J. C.; Berkowitz, A. R.

2017-12-01

Understanding water is central to understanding environmental challenges. Scientists use `big data' and computational models to develop knowledge about the structure and function of complex systems, and to make predictions about changes in climate, weather, hydrology, and ecology. Large environmental systems-related data sets and simulation models are difficult for high school teachers and students to access and make sense of. Comp Hydro, a collaboration across four states and multiple school districts, integrates computational thinking and data-related science practices into water systems instruction to enhance development of scientific model-based reasoning, through curriculum, assessment and teacher professional development. Comp Hydro addresses the need for 1) teaching materials for using data and physical models of hydrological phenomena, 2) building teachers' and students' comfort or familiarity with data analysis and modeling, and 3) infusing the computational knowledge and practices necessary to model and visualize hydrologic processes into instruction. Comp Hydro teams in Baltimore, MD and Fort Collins, CO are integrating teaching about surface water systems into high school courses focusing on flooding (MD) and surface water reservoirs (CO). This interactive session will highlight the successes and challenges of our physical and simulation models in helping teachers and students develop proficiency with computational thinking about surface water. We also will share insights from comparing teacher-led vs. project-led development of curriculum and our simulations.

Plant growth improvement mediated by nitrate capture in co-composted biochar.

PubMed

Kammann, Claudia I; Schmidt, Hans-Peter; Messerschmidt, Nicole; Linsel, Sebastian; Steffens, Diedrich; Müller, Christoph; Koyro, Hans-Werner; Conte, Pellegrino; Joseph, Stephen; Stephen, Joseph

2015-06-09

Soil amendment with pyrogenic carbon (biochar) is discussed as strategy to improve soil fertility to enable economic plus environmental benefits. In temperate soils, however, the use of pure biochar mostly has moderately-negative to -positive yield effects. Here we demonstrate that co-composting considerably promoted biochars' positive effects, largely by nitrate (nutrient) capture and delivery. In a full-factorial growth study with Chenopodium quinoa, biomass yield increased up to 305% in a sandy-poor soil amended with 2% (w/w) co-composted biochar (BC(comp)). Conversely, addition of 2% (w/w) untreated biochar (BC(pure)) decreased the biomass to 60% of the control. Growth-promoting (BC(comp)) as well as growth-reducing (BC(pure)) effects were more pronounced at lower nutrient-supply levels. Electro-ultra filtration and sequential biochar-particle washing revealed that co-composted biochar was nutrient-enriched, particularly with the anions nitrate and phosphate. The captured nitrate in BC(comp) was (1) only partly detectable with standard methods, (2) largely protected against leaching, (3) partly plant-available, and (4) did not stimulate N2O emissions. We hypothesize that surface ageing plus non-conventional ion-water bonding in micro- and nano-pores promoted nitrate capture in biochar particles. Amending (N-rich) bio-waste with biochar may enhance its agronomic value and reduce nutrient losses from bio-wastes and agricultural soils.

COMP report: CPQR technical quality control guidelines for low-dose-rate permanent seed brachytherapy.

PubMed

Beaulieu, Luc; Radford, Dee-Ann; Eduardo Villarreal-Barajas, J

2018-03-14

The Canadian Organization of Medical Physicists (COMP), in close partnership with the Canadian Partnership for Quality Radiotherapy (CPQR) has developed a series of Technical Quality Control (TQC) guidelines for radiation treatment equipment. These guidelines outline the performance objectives that equipment should meet in order to ensure an acceptable level of radiation treatment quality. The TQC guidelines have been rigorously reviewed and field tested in a variety of Canadian radiation treatment facilities. The development process enables rapid review and update to keep the guidelines current with changes in technology. This article contains detailed performance objectives and safety criteria for low-dose-rate (LDR) permanent seed brachytherapy. © 2018 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

Predictive Engineering Tools for Injection-Molded Long-Carbon-Fiber Thermoplastic Composites - Second FY 2015 Quarterly Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, Ba Nghiep; Fifield, Leonard S.; Kijewski, Seth A.

During the second quarter of FY 2015, the following technical progress has been made toward project milestones: 1) Autodesk reviewed 3D fiber orientation distribution (FOD) comparisons and provided support on improving accuracy. 2) Autodesk reviewed fiber length distribution (FLD) data comparisons and provided suggestions, assisted PNNL in FOD and FLD parameter settings optimization, and advised PNNL on appropriate through thickness thermal conductivity for improved frozen layer effect on FOD predictions. Autodesk also participated in project review meetings including preparations and discussions towards passing the go/no-go decision point. 3) Autodesk implemented an improved FOD inlet profile specification method through the partmore » thickness for 3D meshes and provided an updated ASMI research version to PNNL. 4) The University of Illinois (Prof. C.L. Tucker) provided Autodesk with ideas to improve fiber orientation modeling 5) Purdue University re-measured fiber orientation for the fast-fill 50wt% LCF/PA66 edge-gated plaque, and delivered the fiber orientation data for this plaque at the selected locations (named A, B, and C, Figure 1) to PNNL. Purdue also re-measured fiber orientation for locations A on the fast-fill 30wt% LCF/PP and 50wt% LCF/PA66 center-gated plaques, which exhibited anomalous fiber orientation behavior. 6) Purdue University conducted fiber length measurements and delivered the length data to PNNL for the purge materials (slow-fill 30wt% LCF/PP and 30wt% LCF/PA66 purge materials) and PlastiComp plaques selected on the go/no-go list for fiber length model validation (i.e., slow-fill edge-gated 30wt% LCF/PP and 30wt% LCF/PA66 plaques, Locations A, B, and C). 7) PNNL developed a method to recover intact carbon fibers from LCF/PA66 materials. Isolated fibers were shipped to Purdue for length distribution analysis. 8) PNNL completed ASMI mid-plane analyses for all the PlastiComp plaques defined on the go/no-go list for fiber orientation (FO) model validation and compared the predicted fiber orientations with the measured data provided by Purdue at Locations A, B, and C on these plaques. The 15% accuracy criterion based on evaluation of tensile and bending stiffness was used to assess the accuracy in fiber orientation predictions. 9) PNNL completed ASMI mid-plane analyses for all the PlastiComp plaques defined on the go/no-go list for fiber length distribution (FLD) model validation and compared the predicted length distributions with the measured data provided by Purdue at Locations A, B, and C on these plaques. The 15% accuracy criterion based on evaluation of tensile and bending stiffness was used to assess the accuracy in fiber orientation predictions. 10) PNNL tested the new ASMI version received from Autodesk in March 2015, examined and discussed 3D fiber orientation predictions for PlastiComp plaques. 11) PlastiComp, Inc. (PlastiComp), Toyota Research Institute North America (Toyota) and Magna Exteriors and Interiors Corporation (Magna) participated in discussions with team members on the go/no-go plan. Toyota continued the discussion with Magna on tool modification for molding the complex part in order to achieve the target fiber length in the part.« less

Sci-Fri AM: Quality, Safety, and Professional Issues 01: CPQR Technical Quality Control Suite Development including Quality Control Workload Results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malkoske, Kyle; Nielsen, Michelle; Brown, Erika

A close partnership between the Canadian Partnership for Quality Radiotherapy (CPQR) and the Canadian Organization of Medical Physicist’s (COMP) Quality Assurance and Radiation Safety Advisory Committee (QARSAC) has resulted in the development of a suite of Technical Quality Control (TQC) Guidelines for radiation treatment equipment, that outline specific performance objectives and criteria that equipment should meet in order to assure an acceptable level of radiation treatment quality. The framework includes consolidation of existing guidelines and/or literature by expert reviewers, structured stages of public review, external field-testing and ratification by COMP. The adopted framework for the development and maintenance of themore » TQCs ensures the guidelines incorporate input from the medical physics community during development, measures the workload required to perform the QC tests outlined in each TQC, and remain relevant (i.e. “living documents”) through subsequent planned reviews and updates. This presentation will show the Multi-Leaf Linear Accelerator document as an example of how feedback and cross-national work to achieve a robust guidance document. During field-testing, each technology was tested at multiple centres in a variety of clinic environments. As part of the defined feedback, workload data was captured. This lead to average time associated with testing as defined in each TQC document. As a result, for a medium-sized centre comprising 6 linear accelerators and a comprehensive brachytherapy program, we evaluate the physics workload to 1.5 full-time equivalent physicist per year to complete all QC tests listed in this suite.« less

Impact of Subsurface Heterogeneities on nano-Scale Zero Valent Iron Transport

NASA Astrophysics Data System (ADS)

Krol, M. M.; Sleep, B. E.; O'Carroll, D. M.

2011-12-01

Nano-scale zero valent iron (nZVI) has been applied as a remediation technology at sites contaminated with chlorinated compounds and heavy metals. Although laboratory studies have demonstrated high reactivity for the degradation of target contaminants, the success of nZVI in the field has been limited due to poor subsurface mobility. When injected into the subsurface, nZVI tends to aggregate and be retained by subsurface soils. As such nZVI suspensions need to be stabilized for increased mobility. However, even with stabilization, soil heterogeneities can still lead to non-uniform nZVI transport, resulting in poor distribution and consequently decreased degradation of target compounds. Understanding how nZVI transport can be affected by subsurface heterogeneities can aid in improving the technology. This can be done with the use of a numerical model which can simulate nZVI transport. In this study CompSim, a finite difference groundwater model, is used to simulate the movement of nZVI in a two-dimensional domain. CompSim has been shown in previous studies to accurately predict nZVI movement in the subsurface, and is used in this study to examine the impact of soil heterogeneity on nZVI transport. This work also explores the impact of different viscosities of the injected nZVI suspensions (corresponding to different stabilizing polymers) and injection rates on nZVI mobility. Analysis metrics include travel time, travel distance, and average nZVI concentrations. Improving our understanding of the influence of soil heterogeneity on nZVI transport will lead to improved field scale implementation and, potentially, to more effective remediation of contaminated sites.

Determination of nitroaromatic and nitramine type energetic materials in synthetic and real mixtures by cyclic voltammetry.

PubMed

Üzer, Ayşem; Sağlam, Sener; Tekdemir, Yasemin; Ustamehmetoğlu, Belkıs; Sezer, Esma; Erçağ, Erol; Apak, Reşat

2013-10-15

Nitro-explosives contain reducible aromatic -NO2 groups or cyclic >N-NO2 bonds that may undergo reductive cleavage. This work reports the development of a cyclic voltammetric (CV) assay for nitro-aromatics (trinitrotoluene (TNT), dinitrotoluene (DNT)) and nitramines (1,3,5-trinitro-1,3,5-triazacyclohexane (RDX) and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX)) using a glassy carbon electrode. This determination was first used for these energetic materials by resolving current responses of reduction potentials primarily due to one constituent but partly contributed by other constituents. Calibration curves of current intensity versus concentration were linear in the range of 30-120 mg L(-1) for RDX with a limit of detection (LOD) of 10.2 mg L(-1), 40-120 mg L(-1) for HMX (LOD=11.7 mg L(-1)), 40-120 mg L(-1) for TNT (LOD=11.2 mg L(-1)), and 40-140 mg L(-1) for DNT (LOD=10.8 mg L(-1)). Results showed that the CV method could provide a sensitive approach for the simultaneous determination of RDX and TNT in synthetic and real mixtures. Deconvolution of current contributions of mixtures at peak potentials of constituents was performed by multiple linear regression. The proposed method was successfully applied to the analysis of military explosives comp A5 and octol, and method validation was performed both against HPLC on a comp B (TNT+RDX) sample and against GC-MS on real post-blast residual samples containing both explosives. Copyright © 2013 Elsevier B.V. All rights reserved.

15 CFR 990.30 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... the United States, the District of Columbia, the Commonwealth of Puerto Rico, Guam, American Samoa... Comp., p. 22), including the ocean waters of the areas referred to as “eastern special areas” in...

15 CFR 990.30 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... the United States, the District of Columbia, the Commonwealth of Puerto Rico, Guam, American Samoa... Comp., p. 22), including the ocean waters of the areas referred to as “eastern special areas” in...

15 CFR 990.30 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... the United States, the District of Columbia, the Commonwealth of Puerto Rico, Guam, American Samoa... Comp., p. 22), including the ocean waters of the areas referred to as “eastern special areas” in...

15 CFR 990.30 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... the United States, the District of Columbia, the Commonwealth of Puerto Rico, Guam, American Samoa... Comp., p. 22), including the ocean waters of the areas referred to as “eastern special areas” in...

EPA-Health Canada CompTox Collaboration

EPA Science Inventory

Research program of EPA’s National Center for Computational Toxicology addresses chemical screening and prioritization needs for pesticidal inerts, anti-microbials, CCLs, HPVs and MPVs, comprehensive use of HTS technologies to generate.

A randomized controlled pilot trial of modified whole blood versus component therapy in severely injured patients requiring large volume transfusions.

PubMed

Cotton, Bryan A; Podbielski, Jeanette; Camp, Elizabeth; Welch, Timothy; del Junco, Deborah; Bai, Yu; Hobbs, Rhonda; Scroggins, Jamie; Hartwell, Beth; Kozar, Rosemary A; Wade, Charles E; Holcomb, John B

2013-10-01

To determine whether resuscitation of severely injured patients with modified whole blood (mWB) resulted in fewer overall transfusions compared with component (COMP) therapy. For decades, whole blood (WB) was the primary product for resuscitating patients in hemorrhagic shock. After dramatic advances in blood banking in the 1970s, blood donor centers began supplying hospitals with individual components [red blood cell (RBC), plasma, platelets] and removed WB as an available product. However, no studies of efficacy or hemostatic potential in trauma patients were performed before doing so. Single-center, randomized trial of severely injured patients predicted to large transfusion volume. Pregnant patients, prisoners, those younger than 18 years or with more than 20% total body surface area burns (TBSA) burns were excluded. Patients were randomized to mWB (1 U mWB) or COMP therapy (1 U RBC+ 1 U plasma) immediately on arrival. Each group also received 1 U platelets (apheresis or prepooled random donor) for every 6 U of mWB or 6 U of RBC + 6 U plasma. The study was performed under the Exception From Informed Consent (Food and Drug Administration 21 code of federal regulations [CFR] 50.24). Primary outcome was 24-hour transfusion volumes. A total of 107 patients were randomized (55 mWB, 52 COMP therapy) over 14 months. There were no differences in demographics, arrival vitals or laboratory values, injury severity, or mechanism. Transfusions were similar between groups (intent-to-treat analysis). However, when excluding patients with severe brain injury (sensitivity analysis), WB group received less 24-hour RBC (median 3 vs 6, P = 0.02), plasma (4 vs 6, P = 0.02), platelets (0 vs 3, P = 0.09), and total products (11 vs 16, P = 0.02). Compared with COMP therapy, WB did not reduce transfusion volumes in severely injured patients predicted to receive massive transfusion. However, in the sensitivity analysis (patients without severe brain injuries), use of mWB significantly reduced transfusion volumes, achieving the prespecified endpoint of this initial pilot study.

Promoting walking among office employees ― evaluation of a randomized controlled intervention with pedometers and e-mail messages

PubMed Central

2012-01-01

Background The purpose of the study was to evaluate a 6-month intervention to promote office-employees’ walking with pedometers and e-mail messages. Methods Participants were recruited by 10 occupational health care units (OHC) from 20 worksites with 2,230 employees. Voluntary and insufficiently physically active employees (N = 241) were randomized to a pedometer (STEP, N = 123) and a comparison group (COMP, N = 118). STEP included one group meeting, log-monitored pedometer-use and six e-mail messages from OHC. COMP participated in data collection. Reach, effectiveness, adoption, implementation, maintenance (RE-AIM) and costs were assessed with questionnaires (0, 2, 6, 12 months), process evaluation and interviews (12 months). Results The intervention reached 29% (N = 646) of employees in terms of participation willingness. Logistic regression showed that the proportion of walkers tended to increase more in STEP than in COMP at 2 months in “walking for transportation” (Odds ratio 2.12, 95%CI 0.94 to 4.81) and at 6 months in “walking for leisure” (1.86, 95%CI 0.94 to 3.69). Linear model revealed a modest increase in the mean duration of “walking stairs” at 2 and 6 months (Geometric mean ratio 1.26, 95%CI 0.98 to 1.61; 1.27, 0.98 to 1.64). Adoption and implementation succeeded as intended. At 12 months, some traces of the intervention were sustained in 15 worksites, and a slightly higher number of walkers in STEP in comparison with COMP was observed in “walking stairs” (OR 2.24, 95%CI 0.94 to 5.31) and in “walking for leisure” (2.07, 95%CI 0.99 to 4.34). The direct costs of the intervention were 43 Euros per participant. Conclusions The findings indicate only modest impact on some indicators of walking. Future studies should invest in reaching the employees, minimizing attrition rate and using objective walking assessment. Trial registeration ISRCTN79432107 PMID:22672576

Pro-inflammatory cytokines and structural biomarkers are effective to categorize osteoarthritis phenotype and progression in Standardbred racehorses over five years of racing career.

PubMed

Bertuglia, Andrea; Pagliara, Eleonora; Grego, Elena; Ricci, Alessandro; Brkljaca-Bottegaro, Nika

2016-11-08

Joint impact injuries initiate a progressive articular damage finally leading to post-traumatic osteoarthritis (PTOA). Racehorses represent an ideal, naturally available, animal model of the disease. Standardbred racehorses developing traumatic osteoarthritis of the fetlock joint during the first year of their career were enrolled in our study. Age-matched controls were contemporarily included. Biomarker levels of equine osteoarthritis were measured in serum and synovial fluid (SF) at baseline, and repeated yearly over the next 4 years of training (from T1 to T4). The effect of time and disease on the biomarker concentrations were analysed, and their relationship with clinical and radiographic parameters were assessed. We hypothesized that the kinetics of pro-inflammatory cytokines and structural biomarkers of joint disease would demonstrate progression of degenerative joint status during post-traumatic osteoarthritis and clarify the effect of early joint trauma. The concentrations of IL1-ß, IL-6, TNF-α in the SF of PTOA group peaked at T0, decreased at T1, and then progressively increased with time, reaching levels higher than those observed at baseline starting from T3. CTXII and COMP levels were similar in PTOA and control horses at baseline, and increased in serum and synovial fluid of PTOA horses starting from T2 (serum and synovial CTXII, and serum COMP) or T3 (synovial COMP). The percentual change of TNF-α in the SF of the affected joints independently contributed to explaining the radiological changes at T3 vs T2 and T4 vs T3. Temporal changes of selected biomarkers in STBRs with an acute episode of traumatic fetlock OA demonstrated that long-term increased concentrations of inflammatory cytokines, type II collagen fragments and COMP, in the SF and serum, are related to PTOA. Based on the observed decrease in inflammatory merkers at T1, we hypothesize that the progression of PTOA could be effectively modulated by proper treatment strategies. Annual variations of synovial concentration of TNF-α can reliably predict radiographic progression of PTOA.

A modified oral sugar test for evaluation of insulin and glucose dynamics in horses.

PubMed

Lindåse, Sanna; Nostell, Katarina; Bröjer, Johan

2016-10-20

An oral sugar test (OST) using Karo ® Light Corn Syrup has been developed in the USA as a field test for the assessment of insulin dysregulation in horses but the syrup is not available in Scandinavian grocery stores. The aim of the study was to compare the results of a modified OST between horses with equine metabolic syndrome (EMS) and healthy horses using a Scandinavian commercially available glucose syrup (Dansukker glykossirap). In addition, the effect of breed and the repeatability of the test were evaluated. In the present study, clinically healthy horses (7 Shetland ponies, 8 Icelandic horses, 8 Standardbred horses) and 20 horses of various breeds with EMS underwent the modified OST test. The Icelandic horses and Shetland ponies underwent the OST twice. Insulin and glucose data from the OST were used to calculate peak insulin concentration (Peak INS ), time to peak insulin concentration (T-peak INS ), area under the curve for insulin (AUC INS ) and glucose (AUC GLU ) as well as whole body insulin sensitivity index (ISI COMP ). Compared to the healthy group, the EMS group had 6-7 times higher geometric mean for Peak INS and AUC INS and 8 times lower geometric mean for ISI COMP . The EMS group had a delayed T-peak INS compared to the healthy group. There was no effect of breed in the group of healthy horses on Peak INS , T-peak INS , AUC INS , AUC GLU and ISI COMP . Coefficient of variation for repeated tests was 19.8, 19.0 and 17.6 % for Peak INS , AUC INS and ISI COMP respectively. The results of the present study demonstrate that the modified OST appears to be a practical and useful diagnostic tool for assessment of insulin dysregulation in the horse. However, to make it possible to establish the most appropriate sampling interval and to evaluate the accuracy of the modified OST, further studies in horses with a variable degree of insulin resistance are needed, where results from the modified OST are compared with quantitative measurements for IS.

Assessment of Research Interests of First-Year Osteopathic Medical Students.

PubMed

Carter, John; McClellan, Nicholas; McFaul, Derek; Massey, Blaine; Guenther, Elisabeth; Kisby, Glen

2016-07-01

According to a 2014 survey, 59% of students entering allopathic medical school reported previous research experience. However, limited data exist on the amount of research experience that students have before entering osteopathic medical school. A strong understanding of the research skills and level of interest of first-year osteopathic medical students is essential for developing research programs at osteopathic medical schools. Limited data exist on the amount of research experience that students have before starting osteopathic medical school. A strong understanding of the research skills and level of interest of first-year medical students is essential for developing research programs at osteopathic medical schools. To determine the amount of previous research experience of first-year osteopathic medical students, their level of interest in participating in research during medical school, the factors influencing their interest in research, and their research fields of interest. First-year osteopathic medical students (class of 2019) at the Western University of Health Sciences, College of Osteopathic Medicine of the Pacific in Pomona, California (WesternU/COMP), and Pacific-Northwest in Lebanon, Oregon (WesternU/COMP-Northwest), campuses were surveyed about their previous research experiences and whether they were interested in participating in research during medical school. Surveys were administered through an anonymous online portal. Responses were evaluated for evidence of interest in conducting research. Of the 346 osteopathic medical students invited to participate in the study, the response rate was 77% (N=266). A total of 167 from WesternU/COMP and 99 from the WesternU/COMP-Northwest responded. More than 215 students (81%) reported they had participated in research before entering medical school. In addition, 200 students (75%) either expressed a strong interest in participating in research during medical school or were currently conducting research. Among research areas, clinical research was the overwhelming favorite, with 218 students (82%) expressing interest. First-year osteopathic students may have comparable amounts of research experience as allopathic medical students. Although these findings are limited to 2 campuses of 1 osteopathic medical school, they suggest that first-year osteopathic medical students are highly motivated to participate in research while in medical school.

Comparative Proteomic Analysis of Normal and Collagen IX Null Mouse Cartilage Reveals Altered Extracellular Matrix Composition and Novel Components of the Collagen IX Interactome*

PubMed Central

Brachvogel, Bent; Zaucke, Frank; Dave, Keyur; Norris, Emma L.; Stermann, Jacek; Dayakli, Münire; Koch, Manuel; Gorman, Jeffrey J.; Bateman, John F.; Wilson, Richard

2013-01-01

The cartilage extracellular matrix is essential for endochondral bone development and joint function. In addition to the major aggrecan/collagen II framework, the interacting complex of collagen IX, matrilin-3, and cartilage oligomeric matrix protein (COMP) is essential for cartilage matrix stability, as mutations in Col9a1, Col9a2, Col9a3, Comp, and Matn3 genes cause multiple epiphyseal dysplasia, in which patients develop early onset osteoarthritis. In mice, collagen IX ablation results in severely disturbed growth plate organization, hypocellular regions, and abnormal chondrocyte shape. This abnormal differentiation is likely to involve altered cell-matrix interactions but the mechanism is not known. To investigate the molecular basis of the collagen IX null phenotype we analyzed global differences in protein abundance between wild-type and knock-out femoral head cartilage by capillary HPLC tandem mass spectrometry. We identified 297 proteins in 3-day cartilage and 397 proteins in 21-day cartilage. Components that were differentially abundant between wild-type and collagen IX-deficient cartilage included 15 extracellular matrix proteins. Collagen IX ablation was associated with dramatically reduced COMP and matrilin-3, consistent with known interactions. Matrilin-1, matrilin-4, epiphycan, and thrombospondin-4 levels were reduced in collagen IX null cartilage, providing the first in vivo evidence for these proteins belonging to the collagen IX interactome. Thrombospondin-4 expression was reduced at the mRNA level, whereas matrilin-4 was verified as a novel collagen IX-binding protein. Furthermore, changes in TGFβ-induced protein βig-h3 and fibronectin abundance were found in the collagen IX knock-out but not associated with COMP ablation, indicating specific involvement in the abnormal collagen IX null cartilage. In addition, the more widespread expression of collagen XII in the collagen IX-deficient cartilage suggests an attempted compensatory response to the absence of collagen IX. Our differential proteomic analysis of cartilage is a novel approach to identify candidate matrix protein interactions in vivo, underpinning further analysis of mutant cartilage lacking other matrix components or harboring disease-causing mutations. PMID:23530037

Physician role change in managed care: a frontline report.

PubMed

Christian, J H

1998-01-01

Dr. Christian, Vice President and Chief Medical Officer of ManagedComp, Inc., describes the company's new managed compensation program in which the physician's role is expanded to include more accountability.

Experimental evaluation of compost leachates.

DOT National Transportation Integrated Search

2015-09-01

Compost is often used in raingardens, roadsides, and bioretention systems, not only because of : its beneficial properties on soil quality, but also because compost improves water infiltration and : retains stormwater contaminants. However, when comp...

20 CFR 435.33 - Federally-owned and exempt property.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Mathematics and Science Education in Support of the National Education Goals” (3 CFR, 1992 Comp., p. 323... GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, OTHER NON-PROFIT ORGANIZATIONS...

20 CFR 435.33 - Federally-owned and exempt property.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Mathematics and Science Education in Support of the National Education Goals” (3 CFR, 1992 Comp., p. 323... GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, OTHER NON-PROFIT ORGANIZATIONS...

20 CFR 435.33 - Federally-owned and exempt property.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Mathematics and Science Education in Support of the National Education Goals” (3 CFR, 1992 Comp., p. 323... GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, OTHER NON-PROFIT ORGANIZATIONS...

20 CFR 435.33 - Federally-owned and exempt property.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Mathematics and Science Education in Support of the National Education Goals” (3 CFR, 1992 Comp., p. 323... GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, OTHER NON-PROFIT ORGANIZATIONS...

20 CFR 435.33 - Federally-owned and exempt property.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Mathematics and Science Education in Support of the National Education Goals” (3 CFR, 1992 Comp., p. 323... GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, OTHER NON-PROFIT ORGANIZATIONS...

RMP*Comp

EPA Pesticide Factsheets

You can use this free software program to complete the Off-site Consequence Analyses (both worst case scenarios and alternative scenarios) required under the Risk Management Program rule, so that you don't have to do calculations by hand.

32 CFR Appendix A to Part 651 - References

Code of Federal Regulations, 2010 CFR

2010-07-01

... Technology). DOD 5000.2-R Mandatory Procedures for Major Defense Acquisition Programs and Major Automated... Protection of Children from Environmental Health Risks and Safety Risks, 3 CFR, 1997 Comp., p. 198. Executive...

32 CFR Appendix A to Part 651 - References

Code of Federal Regulations, 2011 CFR

2011-07-01

... Technology). DOD 5000.2-R Mandatory Procedures for Major Defense Acquisition Programs and Major Automated... Protection of Children from Environmental Health Risks and Safety Risks, 3 CFR, 1997 Comp., p. 198. Executive...

2 CFR 215.33 - Federally-owned and exempt property.

Code of Federal Regulations, 2013 CFR

2013-01-01

... and Science Education in Support of the National Education Goals” (57 FR 54285, 3 CFR, 1992 Comp., p... GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT...

2 CFR 215.33 - Federally-owned and exempt property.

Code of Federal Regulations, 2011 CFR

2011-01-01

... and Science Education in Support of the National Education Goals” (57 FR 54285, 3 CFR, 1992 Comp., p... GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT...

2 CFR 215.33 - Federally-owned and exempt property.

Code of Federal Regulations, 2012 CFR

2012-01-01

... and Science Education in Support of the National Education Goals” (57 FR 54285, 3 CFR, 1992 Comp., p... GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT...

Publisher Correction: Hierarchical self-entangled carbon nanotube tube networks.

PubMed

Schütt, Fabian; Signetti, Stefano; Krüger, Helge; Röder, Sarah; Smazna, Daria; Kaps, Sören; Gorb, Stanislav N; Mishra, Yogendra Kumar; Pugno, Nicola M; Adelung, Rainer

2018-01-09

The original version of this Article was missing the ORCID ID of Professor Nicola Pugno.Also in the original version of this Article, the third to last sentence of the fourth paragraph of the Results incorrectly read 'However, the stepwise addition of CNTs increases the self-entanglement and thereby the compressive strength value as well as the Young's modulus (up to 2.5 MPa (normalized by density 6.4) and 24.5 MPa (normalized by density 62 MPa cm 3 g -1 ).' The correct version adds the units 'MPa cm 3 g -1 ' to '6.4'.Finally, in the original version of this Article, the y-axis label of Figure 3f incorrectly read 'Comp. strengthy'. The new version corrects that to 'Comp. Strength'.These errors have now been corrected in both the PDF and the HTML versions of the Article.

Triaxial instabilities in rapidly rotating neutron stars

NASA Astrophysics Data System (ADS)

Basak, Arkadip

2018-06-01

Viscosity driven bar mode secular instabilities of rapidly rotating neutron stars are studied using LORENE/Nrotstar code. These instabilities set a more rigorous limit to the rotation frequency of a neutron star than the Kepler frequency/mass-shedding limit. The procedure employed in the code comprises of perturbing an axisymmetric and stationary configuration of a neutron star and studying its evolution by constructing a series of triaxial quasi-equilibrium configurations. Symmetry breaking point was found out for Polytropic as well as 10 realistic equations of states (EOS) from the CompOSE data base. The concept of piecewise polytropic EOSs has been used to comprehend the rotational instability of Realistic EOSs and validated with 19 different Realistic EOSs from CompOSE. The possibility of detecting quasi-periodic gravitational waves from viscosity driven instability with ground-based LIGO/VIRGO interferometers is also discussed very briefly.

Comment on: ‘ERGC: an efficient referential genome compression algorithm’

PubMed Central

Deorowicz, Sebastian; Grabowski, Szymon; Ochoa, Idoia; Hernaez, Mikel; Weissman, Tsachy

2016-01-01

Motivation: Data compression is crucial in effective handling of genomic data. Among several recently published algorithms, ERGC seems to be surprisingly good, easily beating all of the competitors. Results: We evaluated ERGC and the previously proposed algorithms GDC and iDoComp, which are the ones used in the original paper for comparison, on a wide data set including 12 assemblies of human genome (instead of only four of them in the original paper). ERGC wins only when one of the genomes (referential or target) contains mixed-cased letters (which is the case for only the two Korean genomes). In all other cases ERGC is on average an order of magnitude worse than GDC and iDoComp. Contact: sebastian.deorowicz@polsl.pl, iochoa@stanford.edu Supplementary information: Supplementary data are available at Bioinformatics online. PMID:26615213

Proinflammatory and Anabolic Gene Expression Effects of Platelet-Rich Gel Supernatants on Equine Synovial Membrane Explants Challenged with Lipopolysaccharide

PubMed Central

Ríos, Diana L.; Pérez, Jorge E.

2017-01-01

Platelet-rich plasma (PRP) preparations are used in horses with osteoarthritis (OA). However, some controversies remain regarding the ideal concentration of platelets and leukocytes to produce an adequate anti-inflammatory and anabolic response in the synovial membrane. The aims of this study were to study the influence of leukoconcentrated platelet-rich gel (Lc-PRG) and leukoreduced platelet-rich gel (Lr-PRG) supernatants on the quantitative expression of some proinflammatory and anabolic genes in equine synovial membrane explants (SMEs) challenged with lipopolysaccharide (LPS). SMEs from six horses were cultured over 96 h. Then, SMEs were harvested for RNA extraction and quantitative gene expression analysis by RT-qPCR for nuclear factor kappa B (NFκB), matrix metalloproteinase 13 (MMP-13), a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4), collagen type I alpha 1 (COL1A1), collagen type II alpha 1 (COL2A1), and cartilage oligomeric matrix protein (COMP). The 25% and 50% Lc-PRG supernatants led to downregulation of NFκB, MMP-13, ADAMTS-4, COL1A1, COL2A1, and COMP in SMEs. Lr-PRG supernatants (particularly at the 50% concentration) induced downregulation of NFκB, MMP-13, ADAMTS-4, and COL1A1 and upregulation of COL2A1 and COMP. Lr-PRG supernatants should be used for the treatment of inflammatory arthropathies in horses because they have anti-inflammatory and anabolic effects in the synovial membrane. PMID:28761774

Proinflammatory and Anabolic Gene Expression Effects of Platelet-Rich Gel Supernatants on Equine Synovial Membrane Explants Challenged with Lipopolysaccharide.

PubMed

Carmona, Jorge U; Ríos, Diana L; López, Catalina; Álvarez, María E; Pérez, Jorge E

2017-01-01

Platelet-rich plasma (PRP) preparations are used in horses with osteoarthritis (OA). However, some controversies remain regarding the ideal concentration of platelets and leukocytes to produce an adequate anti-inflammatory and anabolic response in the synovial membrane. The aims of this study were to study the influence of leukoconcentrated platelet-rich gel (Lc-PRG) and leukoreduced platelet-rich gel (Lr-PRG) supernatants on the quantitative expression of some proinflammatory and anabolic genes in equine synovial membrane explants (SMEs) challenged with lipopolysaccharide (LPS). SMEs from six horses were cultured over 96 h. Then, SMEs were harvested for RNA extraction and quantitative gene expression analysis by RT-qPCR for nuclear factor kappa B (NF κ B), matrix metalloproteinase 13 (MMP-13), a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4), collagen type I alpha 1 (COL1A1), collagen type II alpha 1 (COL2A1), and cartilage oligomeric matrix protein (COMP). The 25% and 50% Lc-PRG supernatants led to downregulation of NF κ B, MMP-13, ADAMTS-4, COL1A1, COL2A1, and COMP in SMEs. Lr-PRG supernatants (particularly at the 50% concentration) induced downregulation of NF κ B, MMP-13, ADAMTS-4, and COL1A1 and upregulation of COL2A1 and COMP. Lr-PRG supernatants should be used for the treatment of inflammatory arthropathies in horses because they have anti-inflammatory and anabolic effects in the synovial membrane.

Ultrastructural Examination of Diffuse and Specific Tectopulvinar Projections in the Tree Shrew

PubMed Central

CHOMSUNG, RANIDA D.; PETRY, HEYWOOD M.; BICKFORD, MARTHA E.

2008-01-01

Two pathways from the superior colliculus (SC) to the tree shrew pulvinar nucleus have been described, one in which the axons terminate in dense (or specific) patches and one in which the axon arbors are more diffusely organized (Luppino et al. [1988] J. Comp. Neurol. 273:67– 86). As predicted by Lyon et al. ([2003] J. Comp. Neurol. 467:593– 606), we found that anterograde labeling of the diffuse tectopulvinar pathway terminated in the acetylcholinesterase (AChE)-rich dorsal pulvinar (Pd), whereas the specific pathway terminated in the AChE-poor central pulvinar (Pc). Injections of retrograde tracers in Pd labeled non-γ-aminobutyric acid (GABA)-ergic wide-field vertical cells located in the lower stratum griseum superficiale and stratum opticum of the medial SC, whereas injections in Pc labeled similar cells in more lateral regions. At the ultrastructural level, we found that tectopulvinar terminals in both Pd and Pc contact primarily non-GABAergic dendrites. When present, however, synaptic contacts on GABAergic profiles were observed more frequently in Pc (31% of all contacts) compared with Pd (16%). Terminals stained for the type 2 vesicular glutamate transporter, a potential marker of tectopulvinar terminals, also contacted more GABAergic profiles in Pc (19%) compared with Pd (4%). These results provide strong evidence for the division of the tree shrew pulvinar into two distinct tectorecipient zones. The potential functions of these pathways are discussed. J. Comp. Neurol. 510:24 – 46, 2008. PMID:18615501

Biochemical characterisation of navicular hyaline cartilage, navicular fibrocartilage and the deep digital flexor tendon in horses with navicular disease.

PubMed

Viitanen, M; Bird, J; Smith, R; Tulamo, R-M; May, S A

2003-10-01

The study hypothesis was that navicular disease is a process analogous to degenerative joint disease, which leads to changes in navicular fibrocartilage and in deep digital flexor tendon (DDFT) matrix composition and that the process extends to the adjacent distal interphalangeal joint. The objectives were to compare the biochemical composition of the navicular articular and palmar cartilages from 18 horses with navicular disease with 49 horses with no history of front limb lameness, and to compare navicular fibrocartilage with medial meniscus of the stifle and collateral cartilage of the hoof. Cartilage oligomeric matrix protein (COMP), deoxyribonucleic acid (DNA), total glycosaminoglycan (GAG), metalloproteinases MMP-2 and MMP-9 and water content in tissues were measured. Hyaline cartilage had the highest content of COMP and COMP content in hyaline cartilage and tendon was higher in lame horses than in sound horses (p<0.05). The concentration of MMP-2 amount in hyaline cartilage was higher in lame horses than in sound horses. The MMP-2 amounts were significantly higher in tendons compared to other tissue types. Overall, 79% of the lame horses with lesions had MMP-9 in their tendons and the amount was higher than in sound horses (p<0.05). In horses with navicular disease there were matrix changes in navicular hyaline and fibrocartilage as well as the DDFT with potential implications for the pathogenesis and management of the condition.

Diffusion of chaotic field lines in tokamaks

NASA Astrophysics Data System (ADS)

Ali, Halima; Punjabi, Alkesh

2006-10-01

An important instability for the destruction of magnetic surfaces in tokamaks due to island overlapping is the tearing modes. Magnetic fields perturbed by tearing modes are given by the sinusoidal form Br=-1rR∑m,nbm^n ( mθ-n ) . The sinusoidal nature of perturbation creates islands structure near resonant surfaces. In this work, we consider two modes, ( m1,n1 )and ( m2,n2 )that interact with each other, leading to two chains of islands, called primary islands. We use a previously derived Hamiltonian map, the ψ-θ map, with and without higher order control terms to study the diffusion of chaotic field lines. We will present and discuss the results of this work, and discuss its implications with regard to magnetic transport barriers for a fixed q-profile and increasing strength of magnetic perturbations. This work is done under the DOE grant number DE-FG02-01ER54624. 1.A. Punjabi et al, Phys. Rev. lett., 69, 3322 (1992). 2. H. Ali, A. Punjabi, and A. Boozer, Int. J. Comp. Num. Ana. Applications 6, 17 (2005).

Cyromazine

Integrated Risk Information System (IRIS)

Integrated Risk Information System ( IRIS ) Chemical Assessment Summary U.S . Environmental Protection Agency National Center for Environmental Assessment 1 Cyromazine ; CASRN 66215 - 27 - 8Human health assessment information on a chemical substance is included in the IRIS database only after a comp

Intercity Bus Feeder Project Program Analysis

DOT National Transportation Integrated Search

1990-09-01

Following the passage of the Bus Regualtory Reform Act of 1982 (BRRA), intercity : carriers used their increased regulatory flexibility to discontinue many : underutilized rural and small city services. This was understandable, in light : of the comp...

32 CFR 34.22 - Federally owned property.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... 12999 (3 CFR, 1996 Comp., p. 180), “Educational Technology: Ensuring Opportunity for All Children in the... Components are authorized by 15 U.S.C. 3710(i), the Federal Technology Transfer Act, to donate research...

32 CFR 34.22 - Federally owned property.

Code of Federal Regulations, 2013 CFR

2013-07-01

.... 12999 (3 CFR, 1996 Comp., p. 180), “Educational Technology: Ensuring Opportunity for All Children in the... Components are authorized by 15 U.S.C. 3710(i), the Federal Technology Transfer Act, to donate research...

32 CFR 34.22 - Federally owned property.

Code of Federal Regulations, 2011 CFR

2011-07-01

.... 12999 (3 CFR, 1996 Comp., p. 180), “Educational Technology: Ensuring Opportunity for All Children in the... Components are authorized by 15 U.S.C. 3710(i), the Federal Technology Transfer Act, to donate research...

32 CFR 34.22 - Federally owned property.

Code of Federal Regulations, 2014 CFR

2014-07-01

.... 12999 (3 CFR, 1996 Comp., p. 180), “Educational Technology: Ensuring Opportunity for All Children in the... Components are authorized by 15 U.S.C. 3710(i), the Federal Technology Transfer Act, to donate research...

32 CFR 34.22 - Federally owned property.

Code of Federal Regulations, 2012 CFR

2012-07-01

.... 12999 (3 CFR, 1996 Comp., p. 180), “Educational Technology: Ensuring Opportunity for All Children in the... Components are authorized by 15 U.S.C. 3710(i), the Federal Technology Transfer Act, to donate research...

Genetics Home Reference: multiple epiphyseal dysplasia

MedlinePlus

... MedlinePlus (5 links) Diagnostic Tests Drug Therapy Genetic Counseling Palliative Care Surgery and Rehabilitation Related Information How ... manifestations of multiple epiphyseal dysplasia caused by MATN3 versus COMP mutations: a case control study. BMC Musculoskelet ...

Effects of decompression on operator performance.

DOT National Transportation Integrated Search

1966-04-01

The study was performed to provide more quantitative estimates of degradation of pilot performance following decompression and the extent to which a decompression with mask donning interrupts the task of piloting. The experiments utilized a Scow comp...

29 CFR 4.190 - Contract cancellation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... in paragraph (a). Such contract is without warrant of law and has no force and effect and is void ab initio, 33 Comp Gen. 63; Decision of the Comptroller General, B-115051, August 6, 1953. Furthermore, any...

29 CFR 4.190 - Contract cancellation.

Code of Federal Regulations, 2012 CFR

2012-07-01

... in paragraph (a). Such contract is without warrant of law and has no force and effect and is void ab initio, 33 Comp Gen. 63; Decision of the Comptroller General, B-115051, August 6, 1953. Furthermore, any...

29 CFR 4.190 - Contract cancellation.

Code of Federal Regulations, 2013 CFR

2013-07-01

... in paragraph (a). Such contract is without warrant of law and has no force and effect and is void ab initio, 33 Comp Gen. 63; Decision of the Comptroller General, B-115051, August 6, 1953. Furthermore, any...

29 CFR 4.190 - Contract cancellation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... in paragraph (a). Such contract is without warrant of law and has no force and effect and is void ab initio, 33 Comp Gen. 63; Decision of the Comptroller General, B-115051, August 6, 1953. Furthermore, any...

29 CFR 4.190 - Contract cancellation.

Code of Federal Regulations, 2014 CFR

2014-07-01

... in paragraph (a). Such contract is without warrant of law and has no force and effect and is void ab initio, 33 Comp Gen. 63; Decision of the Comptroller General, B-115051, August 6, 1953. Furthermore, any...

32 CFR 767.12 - References for submission of permit application to conduct archeological research.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Cultural Resources Program. (i) Naval Historical Center Instruction 5510.4. (NAVHISTCENINST 5510.4, 14..., 1971-1975 Comp., p. 559 (Protection and Enhancement of the Cultural Environment). (g) Department of...

RMP Guidance for Offsite Consequence Analysis

EPA Pesticide Factsheets

Offsite consequence analysis (OCA) consists of a worst-case release scenario and alternative release scenarios. OCA is required from facilities with chemicals above threshold quantities. RMP*Comp software can be used to perform calculations described here.

Lagrangian statistics in compressible isotropic homogeneous turbulence

NASA Astrophysics Data System (ADS)

Yang, Yantao; Wang, Jianchun; Shi, Yipeng; Chen, Shiyi

2011-11-01

In this work we conducted the Direct Numerical Simulation (DNS) of a forced compressible isotropic homogeneous turbulence and investigated the flow statistics from the Lagrangian point of view, namely the statistics is computed following the passive tracers trajectories. The numerical method combined the Eulerian field solver which was developed by Wang et al. (2010, J. Comp. Phys., 229, 5257-5279), and a Lagrangian module for tracking the tracers and recording the data. The Lagrangian probability density functions (p.d.f.'s) have then been calculated for both kinetic and thermodynamic quantities. In order to isolate the shearing part from the compressing part of the flow, we employed the Helmholtz decomposition to decompose the flow field (mainly the velocity field) into the solenoidal and compressive parts. The solenoidal part was compared with the incompressible case, while the compressibility effect showed up in the compressive part. The Lagrangian structure functions and cross-correlation between various quantities will also be discussed. This work was supported in part by the China's Turbulence Program under Grant No.2009CB724101.

Uncertainties in climate change projections for viticulture in Portugal

NASA Astrophysics Data System (ADS)

Fraga, Helder; Malheiro, Aureliano C.; Moutinho-Pereira, José; Pinto, Joaquim G.; Santos, João A.

2013-04-01

The assessment of climate change impacts on viticulture is often carried out using regional climate model (RCM) outputs. These studies rely on either multi-model ensembles or on single-model approaches. The RCM-ensembles account for uncertainties inherent to the different models. In this study, using a 16-RCM ensemble under the IPCC A1B scenario, the climate change signal (future minus recent-past, 2041-2070 - 1961-2000) of 4 bioclimatic indices (Huglin Index - HI, Dryness Index - DI, Hydrothermal Index - HyI and CompI - Composite Index) over mainland Portugal is analysed. A normalized interquartile range (NIQR) of the 16-member ensemble for each bioclimatic index is assessed in order to quantify the ensemble uncertainty. The results show significant increases in the HI index over most of Portugal, with higher values in Alentejo, Trás-os-Montes and Douro/Porto wine regions, also depicting very low uncertainty. Conversely, the decreases in the DI pattern throughout the country show large uncertainties, except in Minho (northwestern Portugal), where precipitation reaches the highest amounts in Portugal. The HyI shows significant decreases in northwestern Portugal, with relatively low uncertainty all across the country. The CompI depicts significant decreases over Alentejo and increases over Minho, though decreases over Alentejo reveal high uncertainty, while increases over Minho show low uncertainty. The assessment of the uncertainty in climate change projections is of great relevance for the wine industry. Quantifying this uncertainty is crucial, since different models may lead to quite different outcomes and may thereby be as crucial as climate change itself to the winemaking sector. This work is supported by European Union Funds (FEDER/COMPETE - Operational Competitiveness Programme) and by national funds (FCT - Portuguese Foundation for Science and Technology) under the project FCOMP-01-0124-FEDER-022692.

Reducing cement content in concrete mixtures : [research brief].

DOT National Transportation Integrated Search

2011-12-01

Concrete mixtures contain crushed rock or gravel, and sand, bound together by Portland cement in combination with supplemental cementitious materials (SCMs), which harden through a chemical reaction with water. Portland cement is the most costly comp...

The future for Canada-U.S. container port rivalries

DOT National Transportation Integrated Search

2003-06-01

Canada's major container ports have competed successfully against their U.S. counterparts for overseas container traffic. However, the ocean container shipping industry is undergoing changes that will impact on their relationships with ports and comp...

Procedures, cost and effectiveness for deteriorated bridge substructure repair.

DOT National Transportation Integrated Search

2013-03-01

Deterioration of bridge substructures has been a serious concern throughout Wisconsin. Concrete, steel and : timber components all require distinct repair methods which not only address the true cause of the deterioration, : but also protect the comp...

Gender Differences in Marital Status Moderation of Genetic and Environmental Influences on Subjective Health.

PubMed

Finkel, Deborah; Franz, Carol E; Horwitz, Briana; Christensen, Kaare; Gatz, Margaret; Johnson, Wendy; Kaprio, Jaako; Korhonen, Tellervo; Niederheiser, Jenae; Petersen, Inge; Rose, Richard J; Silventoinen, Karri

2015-10-14

From the IGEMS Consortium, data were available from 26,579 individuals aged 23 to 102 years on 3 subjective health items: self-rated health (SRH), health compared to others (COMP), and impact of health on activities (ACT). Marital status was a marker of environmental resources that may moderate genetic and environmental influences on subjective health. Results differed for the 3 subjective health items, indicating that they do not tap the same construct. Although there was little impact of marital status on variance components for women, marital status was a significant modifier of variance in all 3 subjective health measures for men. For both SRH and ACT, single men demonstrated greater shared and nonshared environmental variance than married men. For the COMP variable, genetic variance was greater for single men vs. married men. Results suggest gender differences in the role of marriage as a source of resources that are associated with subjective health.

Magnetic Nulls and Super-Radial Expansion in the Solar Corona

NASA Technical Reports Server (NTRS)

Gibson, Sarah E.; Dalmasse, Kevin; Rachmeler, Laurel A.; De Rosa, Marc L.; Tomczyk, Steven; De Toma, Giuliana; Burkepile, Joan; Galloy, Michael

2017-01-01

Magnetic fields in the Sun's outer atmosphere, the corona, control both solar-wind acceleration and the dynamics of solar eruptions. We present the first clear observational evidence of coronal magnetic nulls in off-limb linearly polarized observations of pseudostreamers, taken by the Coronal Multichannel Polarimeter (CoMP) telescope. These nulls represent regions where magnetic reconnection is likely to act as a catalyst for solar activity.CoMP linear-polarization observations also provide an independent, coronal proxy for magnetic expansion into the solar wind, a quantity often used to parameterize and predict the solar wind speed at Earth. We introduce a new method for explicitly calculating expansion factors from CoMP coronal linear-polarization observations, which does not require photospheric extrapolations. We conclude that linearly polarized light is a powerful new diagnostic of critical coronal magnetic topologies and the expanding magnetic flux tubes that channel the solar wind.

DOC II 32-bit digital optical computer: optoelectronic hardware and software

NASA Astrophysics Data System (ADS)

Stone, Richard V.; Zeise, Frederick F.; Guilfoyle, Peter S.

1991-12-01

This paper describes current electronic hardware subsystems and software code which support OptiComp's 32-bit general purpose digital optical computer (DOC II). The reader is referred to earlier papers presented in this section for a thorough discussion of theory and application regarding DOC II. The primary optoelectronic subsystems include the drive electronics for the multichannel acousto-optic modulators, the avalanche photodiode amplifier, as well as threshold circuitry, and the memory subsystems. This device utilizes a single optical Boolean vector matrix multiplier and its VME based host controller interface in performing various higher level primitives. OptiComp Corporation wishes to acknowledge the financial support of the Office of Naval Research, the National Aeronautics and Space Administration, the Rome Air Development Center, and the Strategic Defense Initiative Office for the funding of this program under contracts N00014-87-C-0077, N00014-89-C-0266 and N00014-89-C- 0225.

Comment on: 'ERGC: an efficient referential genome compression algorithm'.

PubMed

Deorowicz, Sebastian; Grabowski, Szymon; Ochoa, Idoia; Hernaez, Mikel; Weissman, Tsachy

2016-04-01

Data compression is crucial in effective handling of genomic data. Among several recently published algorithms, ERGC seems to be surprisingly good, easily beating all of the competitors. We evaluated ERGC and the previously proposed algorithms GDC and iDoComp, which are the ones used in the original paper for comparison, on a wide data set including 12 assemblies of human genome (instead of only four of them in the original paper). ERGC wins only when one of the genomes (referential or target) contains mixed-cased letters (which is the case for only the two Korean genomes). In all other cases ERGC is on average an order of magnitude worse than GDC and iDoComp. sebastian.deorowicz@polsl.pl, iochoa@stanford.edu Supplementary data are available at Bioinformatics online. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Effect of a Mediterranean Type Diet on Inflammatory and Cartilage Degradation Biomarkers in Patients with Osteoarthritis.

PubMed

Dyer, J; Davison, G; Marcora, S M; Mauger, A R

2017-01-01

To investigate the effects of a Mediterranean type diet on patients with osteoarthritis (OA). Ninety-nine volunteers with OA (aged 31 - 90 years) completed the study (83% female). Southeast of England, UK. Participants were randomly allocated to the dietary intervention (DIET, n = 50) or control (CON, n = 49). The DIET group were asked to follow a Mediterranean type diet for 16 weeks whereas the CON group were asked to follow their normal diet. All participants completed an Arthritis Impact Measurement Scale (AIMS2) pre-, mid- and post- study period. A subset of participants attended a clinic at the start and end of the study for assessment of joint range of motion, ROM (DIET = 33, CON = 28), and to provide blood samples (DIET = 29, CON = 25) for biomarker analysis (including serum cartilage oligomeric matrix protein (sCOMP) (a marker of cartilage degradation) and a panel of other relevant biomarkers including pro- and anti-inflammatory cytokines). There were no differences between groups in the response of any AIMS2 components and most biomarkers (p > 0.05), except the pro-inflammatory cytokine IL-1α, which decreased in the DIET group (~47%, p = 0.010). sCOMP decreased in the DIET group by 1 U/L (~8%, p = 0.014). There was a significant improvement in knee flexion and hip rotation ROM in the DIET group (p < 0.05). The average reduction in sCOMP in the DIET group (1 U/L) represents a meaningful change, but the longer term effects require further study.

5-year results comparing mineral trioxide aggregate and adhesive resin composite for root-end sealing in apical surgery.

PubMed

von Arx, Thomas; Hänni, Stefan; Jensen, Simon Storgård

2014-08-01

Recent meta-analyses of the outcome of apical surgery using modern techniques including microsurgical principles and high-power magnification have yielded higher rates of healing. However, the information is mainly based on 1- to 2-year follow-up data. The present prospective study was designed to re-examine a large sample of teeth treated with apical surgery after 5 years. Patients were recalled 5 years after apical surgery, and treated teeth were classified as healed or not healed based on clinical and radiographic examination. (The latter was performed independently by 3 observers). Two different methods of root-end preparation and filling (primary study parameters) were to be compared (mineral trioxide aggregate [MTA] vs adhesive resin composite [COMP]) without randomization. A total of 271 patients and teeth from a 1-year follow-up sample of 339 could be re-examined after 5 years (dropout rate = 20.1%). The overall rate of healed cases was 84.5% with a significant difference (P = .0003) when comparing MTA (92.5%) and COMP (76.6%). The evaluation of secondary study parameters yielded no significant difference for healing outcome when comparing subcategories (ie, sex, age, type of tooth treated, post/screw, type of surgery). The results from this prospective nonrandomized clinical study with a 5-year follow-up of 271 teeth indicate that MTA exhibited a higher healing rate than COMP in the longitudinal prognosis of root-end sealing. Copyright © 2014 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

Optimizing pKa computation in proteins with pH adapted conformations.

PubMed

Kieseritzky, Gernot; Knapp, Ernst-Walter

2008-05-15

pK(A) in proteins are determined by electrostatic energy computations using a small number of optimized protein conformations derived from crystal structures. In these protein conformations hydrogen positions and geometries of salt bridges on the protein surface were determined self-consistently with the protonation pattern at three pHs (low, ambient, and high). Considering salt bridges at protein surfaces is most relevant, since they open at low and high pH. In the absence of these conformational changes, computed pK(A)(comp) of acidic (basic) groups in salt bridges underestimate (overestimate) experimental pK(A)(exp), dramatically. The pK(A)(comp) for 15 different proteins with 185 known pK(A)(exp) yield an RMSD of 1.12, comparable with two other methods. One of these methods is fully empirical with many adjustable parameters. The other is also based on electrostatic energy computations using many non-optimized side chain conformers but employs larger dielectric constants at short distances of charge pairs that diminish their electrostatic interactions. These empirical corrections that account implicitly for additional conformational flexibility were needed to describe the energetics of salt bridges appropriately. This is not needed in the present approach. The RMSD of the present approach improves if one considers only strongly shifted pK(A)(exp) in contrast to the other methods under these conditions. Our method allows interpreting pK(A)(comp) in terms of pH dependent hydrogen bonding pattern and salt bridge geometries. A web service is provided to perform pK(A) computations. 2007 Wiley-Liss, Inc.

Computational Modeling of Thyroid Hormone Regulated Neurodevelopment for Chemical Prioritization (SOT)

EPA Science Inventory

Thyroid hormones (TH) are critical for normal brain development. Environmental chemicals may disrupt TH homeostasis through a variety of physiological systems including membrane transporters, serum transporters, synthesis and catabolic enzymes, and nuclear receptors. Current comp...

28 CFR 17.1 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Administration DEPARTMENT OF JUSTICE CLASSIFIED NATIONAL SECURITY INFORMATION AND ACCESS TO CLASSIFIED... Comp., p. 391) and implementing directives from the Information Security Oversight Office of the... Security Information and the criteria for access to this information. Accordingly, this part is a revision...

Analytical Fuselage and Wing Weight Estimation of Transport Aircraft

DOT National Transportation Integrated Search

1996-05-01

A method of estimating the load-bearing fuselage weight and wing weight of transport aircraft based on fundamental structural principles has been developed. This method of weight estimation represents a compromise between the rapid assessment of comp...

Modernizing bridge safety inspection with process improvement and digital assistance.

DOT National Transportation Integrated Search

2004-01-01

This research effort was developed to record and analyze the Virginia Department of Transportation (VDOT) bridge/structure inspection processes as an aid to modernizing and automating these inspection processes through the use of mobile personal comp...

28 CFR 17.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Administration DEPARTMENT OF JUSTICE CLASSIFIED NATIONAL SECURITY INFORMATION AND ACCESS TO CLASSIFIED... Comp., p. 391) and implementing directives from the Information Security Oversight Office of the... Security Information and the criteria for access to this information. Accordingly, this part is a revision...

Executive report : toll roads, toll rates, and driver behavior.

DOT National Transportation Integrated Search

2012-12-01

State and federal research has examined toll roads and attempted to identify methods to make toll roads a more attractive option for drivers. Researchers examined various views of toll road transactions and concluded: : Truckers and trucking comp...

Evaluation of field projects using crumb rubber modified asphaltic concrete.

DOT National Transportation Integrated Search

2007-03-01

In 1994, the Louisiana Department of Transportation and Development (LADOTD) initiated a research project to evaluate different crumb-rubber modified (CRM) applications in which the long-term pavement performance of the CRM asphalt pavements was comp...

Software Engineering Education Directory

DTIC Science & Technology

1990-04-01

and Engineering (CMSC 735) Codes: GPEV2 * Textiooks: IEEE Tutoria on Models and Metrics for Software Management and Engameeing by Basi, Victor R...Software Engineering (Comp 227) Codes: GPRY5 Textbooks: IEEE Tutoria on Software Design Techniques by Freeman, Peter and Wasserman, Anthony 1. Software

Open container laws and alcohol involved crashes : some preliminary data

DOT National Transportation Integrated Search

2002-04-01

This report presents the results of a study conducted for the National Highway Traffic Safety Administration (NHTSA) to assess the highway safety effects of laws that prohibit open containers of alcoholic beverages to be located in the passenger comp...

Barriers and Opportunities for the Use of Alternative Technologies to Reduce Nitrogen in Coastal Estuaries

EPA Science Inventory

In coastal New England, many communities wrestling with nitrogen over-enrichment from insufficient wastewater management are considering alternative technologies to supplement traditional sewering technology. In particular, communities on Cape Cod, Massachusetts are actively comp...

Identifying known unknowns using the US EPA's CompTox Chemistry Dashboard

EPA Science Inventory

Chemical features observed using high-resolution mass spectrometry can be tentatively identified using online chemical reference databases by searching molecular formulae and monoisotopic masses and then rank-ordering of the hits using appropriate relevance criteria. The most li...

77 FR 19930 - Amendment of Class E Airspace; Tobe, CO

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-03

...-1963 Comp., p. 389. Sec. 71.1 [Amended] 0 2. The incorporation by reference in 14 CFR 71.1 of the..., and on the west by V-389. Issued in Seattle, Washington, on March 26, 2012. Robert Henry, Acting...

Predictive Engineering Tools for Injection-Molded Long-Carbon-Fiber Thermoplastic Composites - Quarterly Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, Ba Nghiep; Simmons, Kevin L.

This quarterly report summarizes the status for the project planning to initiate all the legal and contract documents required for establishing the subcontracts needed and a Cooperative Research and Development Agreement (CRADA) with Autodesk, Inc., Toyota Motor Engineering and Manufacturing North America (Toyota), and Magna Exterior and Interiors Corporation (Magna). During the first quarter (10/1/2012 to 12/31/2012), the statements of work (SOW) for the subcontracts to Purdue University, University of Illinois, and PlastiComp, Inc. were completed. A draft of the CRADA SOW was sent to Autodesk, Toyota, and Magna for technical and legal reviews. PNNL Legal Services contacted project partners’more » Legal counterparts for preparing legal documents for the project. A non-disclosure agreement was drafted and sent to all the parties for reviews.« less

Predictive Engineering Tools for Injection-Molded Long-Carbon-Fiber Thermoplastic Composites - FY 2015 First Quarterly Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, Ba Nghiep; Fifield, Leonard S.; Kijewski, Seth A.

2015-01-29

During the first quarter of FY 2015, the following technical progress has been made toward project milestones: 1) Autodesk delivered a new research version of ASMI to PNNL. This version includes the improved 3D fiber orientation solver, and the reduced order model (ROM) for fiber length distribution using the proper orthogonal decomposition (POD) implemented in the mid-plane, dual-domain and 3D solvers. 2) Autodesk coordinated a conference paper with PNNL reporting ASMI mid-plane fiber orientation predictions compared with the measured data for two PlastiComp plaques. This paper was accepted for presentation at the 2015 Society for Plastics Engineers (SPE) ANTEC conference.more » 3) The University of Illinois (Prof. Tucker) assisted team members from Purdue with fiber orientation measurement techniques, including interpretation of off-axis cross sections. 4) The University of Illinois assisted Autodesk team members with software implementation of the POD approach for fiber length modeling, and with fiber orientation modeling. 5) The University of Illinois co-authored in the SPE ANTEC paper, participated with the team in discussions of plaque data and model results, and participated in the definition of go/no-go experiments and data. 6) Purdue University (Purdue) conducted fiber orientation measurements for 3 PlastiComp plaques: fast-fill 30wt% LCF/PP center-gated, fast-fill 50wt% LCF/PA66 edge-gated and fast-fill 50wt% LCF/PA66 center-gated plaques, and delivered the fiber orientation data for these plaques at the selected locations (named A, B, and C) to PNNL. However, the data for the fast-fill 50wt% LCF/PA66 edge-gated plaque exhibited unusual variations and could not be used for the model validation. Purdue will re-measure fiber orientation for this plaque. 7) Based on discussions with the University of Illinois Purdue explained the ambiguity in the measurements of the fiber orientation components. 8) PNNL discussed with team members to establish a go/no-go decision plan for the project and submitted the established plan to DOE. 9) PNNL performed ASMI mid-plane analyses for the fast-fill center-gated 30wt% LCF/PP and 50wt% LCF/PA66 plaques and compared the predicted fiber orientations with the measured data provided by Purdue at Locations A, B, and C on these plaques. 10) Based on discussions with the University of Illinois and Autodesk, PNNL proposed a procedure to adjust fiber orientation data for Location A of the center-gated plaques so that the data can be expressed and interpreted in the flow/cross-flow direction coordinate system. 11) PNNL tested the new ASMI version received from Autodesk, examined and discussed 3D fiber orientation predictions for PlastiComp plaques. 12) PlastiComp, Inc. (PlastiComp), Toyota Research Institute North America (Toyota) and Magna Exteriors and Interiors Corp. (Magna) participated in discussions with team members on the go/no-go plan and the issues related to fiber length measurements. Toyota continued the discussion with Magna on tool modification for molding the complex part in order to achieve the target fiber length in the part.« less

Fertigation uniformity under sprinkler irrigation: evaluation and analysis

USDA-ARS?s Scientific Manuscript database

n modern farming systems, fertigation is widely practiced as a cost effective and convenient method for applying soluble fertilizers to crops. Along with efficiency and adequacy, uniformity is an important fertigation performance evaluation criterion. Fertigation uniformity is defined here as a comp...

In Defence of Ubuntu

ERIC Educational Resources Information Center

Letseka, Moeketsi

2012-01-01

The article defends ubuntu against the assault by Enslin and Horsthemke ("Comp Educ" 40(4):545-558, 2004). It challenges claims that the Africanist/Afrocentrist project, in which the philosophy of ubuntu is central, faces numerous problems, involves substantial political, moral, epistemological and educational errors, and should…

Atmospheric boundary layer evening transitions over West Texas

USDA-ARS?s Scientific Manuscript database

A systemic analysis of the atmospheric boundary layer behavior during some evening transitions over West Texas was done using the data from an extensive array of instruments which included small and large aperture scintillometers, net radiometers, and meteorological stations. The analysis also comp...

Investigating the cost-effectiveness of nutrient credit use as an option for stormwater permitting requirements.

DOT National Transportation Integrated Search

2014-07-01

The purpose of this study was to determine the feasibility of the Virginia Department of Transportation (VDOT) : participating in water quality trading (WQT) in lieu of constructing onsite structural best management practices (BMPs) to : achieve comp...

A Risk-based Prioritization Strategy for Thyroid Disruption Under EDSP21

EPA Science Inventory

The US Environmental Protection Agency (EPA) established the Endocrine Disruptor Screening Program (EDSP) to determine whether certain substances may have an effect in humans or wildlife that disrupt the estrogen, androgen or thyroid axes. The EDSP is now utilizing comp...

ADVANCED COMPUTATIONAL METHODS IN DOSE MODELING

EPA Science Inventory

The overall goal of the EPA-ORD NERL research program on Computational Toxicology (CompTox) is to provide the Agency with the tools of modern chemistry, biology, and computing to improve quantitative risk assessments and reduce uncertainties in the source-to-adverse outcome conti...

76 FR 79270 - Aviation Proceedings, Agreements Filed the Week Ending December 3, 2011

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-21

...: Members of the International Air Transport Association. Subject: Composite Passenger Tariff Coordinating Conference Singapore, 14 October 2011. Composite Resolution 017i. (Memo PTC COMP 1652,). Intended Effective... of the International Air Transport Association. Subject :Composite Passenger Tariff Coordinating...

LIFE AFTER COMPETITIVE EXCLUSION: AN ALTERNATIVE STRATEGY FOR A COMPETITIVE INFERIOR

EPA Science Inventory

Experimental manipulations in the rocky intertidal have demonstrated that in the absence of predation (Paine 1966, 1974) or physical disturbance (Dayton 1971) a competitive dominant species can monopolize the primary space, thereby excluding competitors. he endpoint of this compe...

Acrylamide in processed potato products

USDA-ARS?s Scientific Manuscript database

Trace amounts of acrylamide are found in many foods cooked at high temperatures. Acrylamide in processed potato products is formed from reducing sugars and asparagine and is a product of the Maillard reaction. Processed potato products including fries and chips are relatively high in acrylamide comp...

77 FR 4708 - Proposed Amendment of Class E Airspace; Tobe, CO

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-31

.... 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 [Amended] 2. The incorporation by reference... the southeast by V-263, and on the west by V-389. Issued in Seattle, Washington, on January 23, 2012...

Pyrethroid insecticide accumulation in primary cultures of cortical neurons in vitro

EPA Science Inventory

Primary cultures of neurons have been widely utilized to study the actions of pyrethroids and other neurotoxicants, with the presumption that the media concentration accurately reflects the dose received by the cells. However, recent studies have demonstrated that lipophilic comp...

Crash cost estimates by maximum police-reported injury severity within selected crash geometrics

DOT National Transportation Integrated Search

2005-10-01

This paper presents estimates for the economic (human capital) and comprehensive costs per crash for six KABCO groupings within 22 selected crash types and within two speed limit categories (=80 km/h (>= 50 mi/h)). The comp...

75 FR 7043 - Investigations Regarding Certifications of Eligibility To Apply for Worker Adjustment Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-16

... Valley, AL 01/25/10 01/15/10 Office (Comp). 73343 Convergys, IMG (Wkrs)...... Lake Mary, FL......... 01... Tardy-Conners Group, LLC Monson, ME 01/26/10 01/22/10 (Wkrs). 73360 Mann-Hummel Advanced Louisville, KY...

ADVANCED COMPUTATIONAL METHODS IN DOSE MODELING: APPLICATION OF COMPUTATIONAL BIOPHYSICAL TRANSPORT, COMPUTATIONAL CHEMISTRY, AND COMPUTATIONAL BIOLOGY

EPA Science Inventory

Computational toxicology (CompTox) leverages the significant gains in computing power and computational techniques (e.g., numerical approaches, structure-activity relationships, bioinformatics) realized over the last few years, thereby reducing costs and increasing efficiency i...

A GLOBAL VIEW OF VELOCITY FLUCTUATIONS IN THE CORONA BELOW 1.3 R {sub ⊙} WITH CoMP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morton, R. J.; Tomczyk, S.; Pinto, R. F., E-mail: richard.morton@northumbria.ac.uk

The Coronal Multi-channel Polarimeter (CoMP) has previously demonstrated the presence of Doppler velocity fluctuations in the solar corona. The observed fluctuations are thought to be transverse waves, i.e., highly incompressible motions whose restoring force is dominated by the magnetic tension, some of which demonstrate clear periodicity. We aim to exploit CoMP’s ability to provide high cadence observations of the off-limb corona to investigate the properties of velocity fluctuations in a range of coronal features, providing insight into how (whether) the properties of the waves are influenced by the varying magnetic topology in active regions, quiet Sun and open field regions.more » An analysis of Doppler velocity time-series of the solar corona from the 10747 Å Iron xiii line is performed, determining the velocity power spectrum and using it as a tool to probe wave behavior. Further, the average phase speed and density for each region are estimated and used to compute the spectra for energy density and energy flux. In addition, we assess the noise levels associated with the CoMP data, deriving analytic formulae for the uncertainty on Doppler velocity measurements and providing a comparison by estimating the noise from the data. It is found that the entire corona is replete with transverse wave behavior. The corresponding power spectra indicate that the observed velocity fluctuations are predominately generated by stochastic processes, with the spectral slope of the power varying between the different magnetic regions. Most strikingly, all power spectra reveal the presence of enhanced power occurring at ∼3 mHz, potentially implying that the excitation of coronal transverse waves by p -modes is a global phenomenon.« less

Coronal Seismology: The Search for Propagating Waves in Coronal Loops

NASA Astrophysics Data System (ADS)

Schad, Thomas A.; Seeley, D.; Keil, S. L.; Tomczyk, S.

2007-05-01

We report on Doppler observations of the solar corona obtained in the Fe XeXIII 1074.7nm coronal emission line with the HAO Coronal Multi-Channel Polarimeter (CoMP) mounted on the NSO Coronal One Shot coronagraph located in the Hilltop Facility of NSO/Sacramento Peak. The COMP is a tunable filtergraph instrument that records the entire corona from the edge of the occulting disk at approximately 1.03 Rsun out to 1.4 Rsun with a spatial resolution of about 4” x 4”. COMP can be rapidly scanned through the spectral line while recording orthogonal states of linear and circular polarization. The two dimensional spatial resolution allows us to correlate temporal fluctuations observed in one part of the corona with those seen at other locations, in particular along coronal loops. Using cross spectral analysis we find that the observations reveal upward propagating waves that are characterized by Doppler shifts with rms velocities of 0.3 km/s, peak wave power in the 3-5 mHz frequency range, and phase speeds 1-3 Mm/s. The wave trajectories are consistent with the direction of the magnetic field inferred from the linear polarization measurements. We discuss the phase and coherence of these waves as a function of height in the corona and relate our findings to previous observations. The observed waves appear to be Alfvenic in character. "Thomas Schad was supported through the National Solar Observatory Research Experiences for Undergraduate (REU) site program, which is co-funded by the Department of Defense in partnership with the National Science Foundation REU Program." Daniel Seeley was supported through the National Solar Observatory Research Experience for Teachers (RET) site program, which is funded by the National Science Foundation RET program.

Baseline Fuel Economy and Emissions Tests of a Chrysler 1978, 225 CID Engine

DOT National Transportation Integrated Search

1980-09-01

This document reports on baseline engine tests of a Chrysler 1978, 225 CID, six-cylinder engine. The tests were conducted in the Automotive Research Laboratory at the Transportation Systems Center. Test results presented herein are also filed on comp...

Communication and coordination demands of railroad roadway worker activities and implications for new technology

DOT National Transportation Integrated Search

2007-11-01

This report documents the results of a cognitive task analysis (CTA) that examined the cognitive and collaborative demands and : activities of railroad roadway workers. The purpose of the CTA of roadway workers was to understand the factors that comp...

The CompTox Chemistry Dashboard - A Community Data Resource for Environmental Chemistry

EPA Science Inventory

Despite an abundance of online databases providing access to chemical data, there is increasing demand for high-quality, structure-curated, open data to meet the various needs of the environmental sciences and computational toxicology communities. The U.S. Environmental Protectio...

7 CFR 1794.2 - Authority.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 12 2014-01-01 2013-01-01 true Authority. 1794.2 Section 1794.2 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE... Enhancement of the Cultural Environment (3 CFR, 1971 Comp., p. 154); (5) E.O. 11514, Protection and...

7 CFR 1794.2 - Authority.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 12 2013-01-01 2013-01-01 false Authority. 1794.2 Section 1794.2 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE... Enhancement of the Cultural Environment (3 CFR, 1971 Comp., p. 154); (5) E.O. 11514, Protection and...

7 CFR 1794.2 - Authority.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 12 2010-01-01 2010-01-01 false Authority. 1794.2 Section 1794.2 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE... Enhancement of the Cultural Environment (3 CFR, 1971 Comp., p. 154); (5) E.O. 11514, Protection and...

INTERCOMPARISON STUDY OF ATMOSPHERIC MERCURY MODELS: 1. COMPARISON OF MODELS WITH SHORT-TERM MEASUREMENTS

EPA Science Inventory

Five regional scale models with a horizontal domain covering the European continent and its surrounding seas, one hemispheric and one global scale model participated in an atmospheric mercury modelling intercomparison study. Model-predicted concentrations in ambient air were comp...

A Temperature-Based Monitoring System for Scour and Deposition at Bridge Piers

DOT National Transportation Integrated Search

2017-05-01

Stream flows around a bridge pier can be fast and highly turbulent causing large shear stresses that may mobilize streambed sediment resulting in scour around bridge foundations. Scour is the leading cause of bridge failure in the USA because it comp...

A SPATIALLY EXPLICIT HIERARCHICAL APPROACH TO MODELING COMPLEX ECOLOGICAL SYSTEMS: THEORY AND APPLICATIONS. (R827676)

EPA Science Inventory

Ecological systems are generally considered among the most complex because they are characterized by a large number of diverse components, nonlinear interactions, scale multiplicity, and spatial heterogeneity. Hierarchy theory, as well as empirical evidence, suggests that comp...

How Do Land-Use and Climate Change Affect Watershed Health? A Scenario-Based Analysis

EPA Science Inventory

With the growing emphasis on biofuel crops and potential impacts of climate variability and change, there is a need to quantify their effects on hydrological processes for developing watershed management plans. Environmental consequences are currently estimated by utilizing comp...

7 CFR 2.96 - Director, Office of Operations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... actions are taken for the prevention, control, and abatement of environmental pollution. (2) Provide... Federal Environmental, Energy, and Transportation Management,” 3 CFR, 2007 Comp., p. 193, and 13514, “Federal Leadership in Environmental, Energy, and Economic Performance” (74 FR 52117, Oct. 8, 2009). (iii...

7 CFR 2.96 - Director, Office of Operations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... actions are taken for the prevention, control, and abatement of environmental pollution. (2) Provide... Federal Environmental, Energy, and Transportation Management,” 3 CFR, 2007 Comp., p. 193, and 13514, “Federal Leadership in Environmental, Energy, and Economic Performance” (74 FR 52117, Oct. 8, 2009). (iii...

7 CFR 2.96 - Director, Office of Operations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... actions are taken for the prevention, control, and abatement of environmental pollution. (2) Provide... Federal Environmental, Energy, and Transportation Management,” 3 CFR, 2007 Comp., p. 193, and 13514, “Federal Leadership in Environmental, Energy, and Economic Performance” (74 FR 52117, Oct. 8, 2009). (iii...

7 CFR 2.96 - Director, Office of Operations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... actions are taken for the prevention, control, and abatement of environmental pollution. (2) Provide... Federal Environmental, Energy, and Transportation Management,” 3 CFR, 2007 Comp., p. 193, and 13514, “Federal Leadership in Environmental, Energy, and Economic Performance” (74 FR 52117, Oct. 8, 2009). (iii...

Determination of Biogenic Amines with HPLC-APCI-MS

USDA-ARS?s Scientific Manuscript database

Determination of biogenic amines in fish samples can be used as a quality attribute and are commonly performed using a derivatization step followed by high pressure liquid chromatography (HPLC) and UV detection. Over estimation and misidentification of biogenic amines can occur when interfering comp...

Implementation of the soil compactor analyzer into test method TEX-113-E : technical report.

DOT National Transportation Integrated Search

2012-04-01

Test method Tex-113-E prepares laboratory aggregate base test specimens with an impact hammer : compactor. These specimens are used for compaction characteristics and design tests. Although the : historical Tex-113-E required a certain amount of comp...

International Suspect Screening: NORMAN Suspect Exchange meets the US EPA CompTox Chemistry Dashboard (ICCE 2017 Oslo)

EPA Science Inventory

Members of the European NORMAN Network of Environmental Laboratories (www.norman-network.com) have many substance lists, including targets, suspects, surfactants, perfluorinated substances and regulated, partially confidential data sets of complex mixtures. The NORMAN Suspect Lis...

25 CFR 211.7 - Environmental studies.

Code of Federal Regulations, 2011 CFR

2011-04-01

.... (b) The Secretary shall ensure that all necessary surveys are performed and clearances obtained in... Enhancement of the Cultural Environment (3 CFR, 1971 through 1975 Comp., p. 559). If these surveys indicate... other related research is conducted and ensure that complete data describing the historic property is...

25 CFR 211.7 - Environmental studies.

Code of Federal Regulations, 2010 CFR

2010-04-01

.... (b) The Secretary shall ensure that all necessary surveys are performed and clearances obtained in... Enhancement of the Cultural Environment (3 CFR, 1971 through 1975 Comp., p. 559). If these surveys indicate... other related research is conducted and ensure that complete data describing the historic property is...

25 CFR 211.7 - Environmental studies.

Code of Federal Regulations, 2014 CFR

2014-04-01

.... (b) The Secretary shall ensure that all necessary surveys are performed and clearances obtained in... Enhancement of the Cultural Environment (3 CFR, 1971 through 1975 Comp., p. 559). If these surveys indicate... other related research is conducted and ensure that complete data describing the historic property is...

25 CFR 211.7 - Environmental studies.

Code of Federal Regulations, 2012 CFR

2012-04-01

.... (b) The Secretary shall ensure that all necessary surveys are performed and clearances obtained in... Enhancement of the Cultural Environment (3 CFR, 1971 through 1975 Comp., p. 559). If these surveys indicate... other related research is conducted and ensure that complete data describing the historic property is...

25 CFR 211.7 - Environmental studies.

Code of Federal Regulations, 2013 CFR

2013-04-01

.... (b) The Secretary shall ensure that all necessary surveys are performed and clearances obtained in... Enhancement of the Cultural Environment (3 CFR, 1971 through 1975 Comp., p. 559). If these surveys indicate... other related research is conducted and ensure that complete data describing the historic property is...

Vibration and Temperature Survey Production CH-47C Helicopter

DTIC Science & Technology

1975-09-01

energy level. Comp eon with the Mitiary Studard 16. Figure C show% a laboratory vibration test curve for equipment installed in helicopters taken...February 1975. 12. Publication, Instut Royale Meteorologique de Belgique, Donnes du Rayornnement Solair a Leopoldville, Periode 1953-1962, 1965. 13

Characterization of nuclear microsatellite markers from Agrostis species

EPA Science Inventory

Agrostis stolonifera L. (creeping bentgrass) is a widely distributed, out-crossing, wind-pollinated, perennial grass that has been genetically engineered for a variety of traits including herbicide, disease and insect resistance. This allotetraploid species (A2A2A3A3 genomic comp...

High-Throughput Toxicokinetics (HTTK) R package (CompTox CoP presentation)

EPA Science Inventory

Toxicokinetics (TK) provides a bridge between HTS and HTE by predicting tissue concentrations due to exposure, but traditional TK methods are resource intensive. Relatively high throughput TK (HTTK) methods have been used by the pharmaceutical industry to determine range of effic...

How to Submit a Risk Management Plan (RMP) to EPA

EPA Pesticide Factsheets

RMP*eSubmit software is the only way to submit RMPs. After you have prepared your plan using RMP*eSubmit, you may also re-submit, correct, or withdraw an RMP. Another electronic tool, RMP*Comp, performs the required off-site consequence analysis.

Grid-coordinate generation program

USGS Publications Warehouse

Cosner, Oliver J.; Horwich, Esther

1974-01-01

This program description of the grid-coordinate generation program is written for computer users who are familiar with digital aquifer models. The program computes the coordinates for a variable grid -used in the 'Pinder Model' (a finite-difference aquifer simulator), for input to the CalComp GPCP (general purpose contouring program). The program adjusts the y-value by a user-supplied constant in order to transpose the origin of the model grid from the upper left-hand corner to the lower left-hand corner of the grid. The user has the options of, (1.) choosing the boundaries of the plot; (2.) adjusting the z-values (altitudes) by a constant; (3.) deleting superfluous z-values and (4.) subtracting the simulated surfaces from each other to obtain the decline. Output of this program includes the fixed format CNTL data cards and the other data cards required for input to GPCP. The output from GPCP then is used to produce a potentiometric map or a decline map by means of the CalComp plotter.

Effect of support flexibilty and damping on the dynamic response of a single mass flexible rotor in elastic bearings

NASA Technical Reports Server (NTRS)

Kirk, R. G.; Gunter, E. J.

1972-01-01

A steady state analysis of the shaft and the bearing housing motion was made by assuming synchronous precession of the system. The conditions under which the support system would act as a dynamic vibration absorber at the rotor critical speed were studied; plots of the rotor and support amplitudes, phase angles, and forces transmitted were evaluated by the computer, and the performance curves were automatically plotted by a CalComp plotter unit. Curves are presented on the optimization of the support housing characteristics to attenuate the rotor unbalance response over the entire rotor speed range. The complete transient motion including rotor unbalance was examined by integrating the equations of motion numerically using a modified fourth order Runge-Kutta procedure, and the resulting whirl orbits were plotted by the CalComp plotter unit. The results of the transient analysis are discussed with regards to the design optimization procedure derived from the steady-state analysis.

EFFECTS OF CHLORINATION ON THE PERSISTENCE OF PHARMACEUTICALS IN THE ENVIRONMENT

EPA Science Inventory

In the past decade, the identification of pharmaceuticals in surface (Jones et al. 2001; Ternes 1998), ground (Sacher et al. 2001) and drinking (Heberer 2002) waters has attracted the attention of both the scientific and lay communities. Although the concentrations of these comp...

24 CFR 50.4 - Related Federal laws and authorities.

Code of Federal Regulations, 2013 CFR

2013-04-01

... of Wetlands), (3 CFR, 1977 Comp., p. 121). (c) Coastal areas protection and management. (1) The... and Urban Development PROTECTION AND ENHANCEMENT OF ENVIRONMENTAL QUALITY General: Federal Laws and... U.S.C. 470 et seq.), as amended. (2) Executive Order 11593, Protection and Enhancement of the...

24 CFR 50.4 - Related Federal laws and authorities.

Code of Federal Regulations, 2011 CFR

2011-04-01

... of Wetlands), (3 CFR, 1977 Comp., p. 121). (c) Coastal areas protection and management. (1) The... and Urban Development PROTECTION AND ENHANCEMENT OF ENVIRONMENTAL QUALITY General: Federal Laws and... U.S.C. 470 et seq.), as amended. (2) Executive Order 11593, Protection and Enhancement of the...

24 CFR 50.4 - Related Federal laws and authorities.

Code of Federal Regulations, 2012 CFR

2012-04-01

... of Wetlands), (3 CFR, 1977 Comp., p. 121). (c) Coastal areas protection and management. (1) The... and Urban Development PROTECTION AND ENHANCEMENT OF ENVIRONMENTAL QUALITY General: Federal Laws and... U.S.C. 470 et seq.), as amended. (2) Executive Order 11593, Protection and Enhancement of the...

24 CFR 50.4 - Related Federal laws and authorities.

Code of Federal Regulations, 2014 CFR

2014-04-01

... CFR, 1977 Comp., p. 121)—24 CFR part 55, Floodplain Management and Protection of Wetlands. (c) Coastal areas protection and management. (1) The Coastal Barrier Resources Act, as amended by the Coastal... and Urban Development PROTECTION AND ENHANCEMENT OF ENVIRONMENTAL QUALITY General: Federal Laws and...

24 CFR 50.4 - Related Federal laws and authorities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... of Wetlands), (3 CFR, 1977 Comp., p. 121). (c) Coastal areas protection and management. (1) The... and Urban Development PROTECTION AND ENHANCEMENT OF ENVIRONMENTAL QUALITY General: Federal Laws and... U.S.C. 470 et seq.), as amended. (2) Executive Order 11593, Protection and Enhancement of the...

Chemical composition and bioactivity studies of Alpinia nigra essential oils

USDA-ARS?s Scientific Manuscript database

Free radical scavenging, bactericidal and bitting deterrent properties of Alpinia nigra essential oils (EOs) were investigated in the present study. Chemical composition of the EOs were analyzed using GC-MS/GC-FID which revealed the presence of 63 constituents including ß-caryophyllene as major comp...

34 CFR 85.900 - Adequate evidence.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 1 2011-07-01 2011-07-01 false Adequate evidence. 85.900 Section 85.900 Education Office of the Secretary, Department of Education GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT... reasonable belief that a particular act or omission has occurred. (Authority: E.O. 12549 (3 CFR, 1986 Comp...

34 CFR 85.900 - Adequate evidence.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Adequate evidence. 85.900 Section 85.900 Education Office of the Secretary, Department of Education GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT... reasonable belief that a particular act or omission has occurred. Authority: E.O. 12549 (3 CFR, 1986 Comp., p...

LIGHTING FOR READING: DESIGNING AN LED LUMINAIRE FOR HOMES AND OFFICES

EPA Science Inventory

Energy waste from traditional incandescent light bulbs was reduced by fluorescent lamps, but they pose a threat to the environment due to the mercury in each tube and disposal issues. Light emitting diodes (LEDs) provide superior energy efficiency, longer life, toxin-free comp...

Insulin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal gland

USDA-ARS?s Scientific Manuscript database

The mammalian pineal gland synthesizes melatonin in a circadian manner, peaking during the dark phase. This synthesis is primarily regulated by sympathetic innervations via noradrenergic fibers, but is also modulated by many peptidergic and hormonal systems. A growing number of studies reveal a comp...

ToxCast Profiling in a Human Stem Cell Assay for Developmental Toxicity (CompTox CoP)

EPA Science Inventory

Standard practice for assessing disruptions in embryogenesis involves testing pregnant animals of two species, typically rats and rabbits, exposed during major organogenesis and evaluated just prior to term. Under this design the major manifestations of developmental toxicity are...

2007 motor vehicle occupant safety survey : use of and support for emergency medical services systems.

DOT National Transportation Integrated Search

2009-09-01

The Motor Vehicle Occupant Safety Survey (MVOSS) is a national telephone survey administered by NHTSA on a periodic basis to obtain data on attitudes, knowledge, and self-reported behavior primarily in areas of occupant protection. The sample is comp...

Structure identification by Mass Spectrometry Non-Targeted Analysis using the US EPA’s CompTox Chemistry Dashboard

EPA Science Inventory

Identification of unknowns in mass spectrometry based non-targeted analyses (NTA) requires the integration of complementary pieces of data to arrive at a confident, consensus structure. Researchers use chemical reference databases, spectral matching, fragment prediction tools, r...

75 FR 10325 - Investigations Regarding Certifications of Eligibility To Apply for Worker Adjustment Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-05

... Systems (Comp) Keller, TX 02/17/10 02/10/10 73477 International Game Reno, NV 02/17/10 02/05/10 Technology.../10 Company (USW). 73495 Perkinelmer Health Sciences, Shelton, CT 02/18/10 02/08/10 Inc. (Wkrs). 73496...

Induction of Endometriosis in Mice: A New Model Sensitive to Estrogen

EPA Science Inventory

Endometriosis consists of the growth of endometrial tissue outside the uterus. A rat model of endometriosis is available to evaluate the potential for environmental chemicals to promote the disease but may he relatively insensitive for the evaluation of the hazard of certain comp...

Effect of vegetative canopy architecture on vertical transport of massless particles

USDA-ARS?s Scientific Manuscript database

A series of large-eddy simulations were performed to examine the effect of canopy architecture on particle dispersion. A heterogeneous canopy geometry was simulated that consists of a set of infinitely repeating vegetation rows. Simulations in which row structure was approximately resolved were comp...

Amnesia Production by Visual Stimulation.

DTIC Science & Technology

1982-12-01

electroconvulsive shock-produced retro- grade amnesia in the rat. J Comp Physiol Psychol 88:373-377 (1975). 5. Cronholm, B., and L. Molander. Memory...disturbances after electrocon- vulsive therapy : 5. Conditions one month after a series of treat- ments. Acta Psychiatr Scand 40:211-216 (1964). 6. Dinc, H. I

77 FR 35370 - Combined Notice of Filings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-13

... Pipeline Comp. Description: Company Name Change to be effective 7/1/2012. Filed Date: 5/31/12. Accession... Natural Gas Service Company. Description: El Paso Natural Gas Company's 2011 (Jan-Mar) Penalty Credit... Numbers: RP12-791-000. Applicants: Dauphin Island Gathering Partners. Description: Negotiated Rates 2012...

Evaluation of alternative mulches for blueberry over five production seasons

USDA-ARS?s Scientific Manuscript database

Highbush blueberry (Vaccinium corymbosum L.) is a calcifuge (acid-loving) plant that responds favorably to mulching with organic matter (OM). Until recently, most blueberry plantings in our region were grown with a mulch of douglas-fir sawdust, with additional nitrogen (N) fertilizer applied to comp...

STABILITY EVALUATION OF MULTICOMPONENT EPA PROTOCOL GASES

EPA Science Inventory

Acid rain occurs when sulfur dioxide and nitrogen oxide emissions are transformed in the atmosphere and return to earth in rain, fog or snow. ost of the emissions are from the burning of fossil fuels by electric utilities. he electric utilities must reduce their emissions to comp...

32 CFR 9.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-07-01

... MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.1 Purpose. This part implements policy, assigns responsibilities, and prescribes procedures under the United States... of Certain Non-Citizens in the War Against Terrorism” (3 CFR, 2001 comp., p. 918, 66 FR 57833), for...

Simulation and Design of Nanocomposite for Application in Ballistic Protection

DTIC Science & Technology

2008-12-01

diene terpolymer ( EPDM ) nanocomposites with organo- montmorillonite (OMMT). It was found that the tensile modulus can be increased by 60% and...Y. D. and Li, W., 2005: Morphology and characterization of clay-reinforced EPDM nanocomposites, J. Comp. Mat., 39, 745- 754. [3] Avila, A. F

Comparative proteomic analysis of normal and collagen IX null mouse cartilage reveals altered extracellular matrix composition and novel components of the collagen IX interactome.

PubMed

Brachvogel, Bent; Zaucke, Frank; Dave, Keyur; Norris, Emma L; Stermann, Jacek; Dayakli, Münire; Koch, Manuel; Gorman, Jeffrey J; Bateman, John F; Wilson, Richard

2013-05-10

Collagen IX is an integral cartilage extracellular matrix component important in skeletal development and joint function. Proteomic analysis and validation studies revealed novel alterations in collagen IX null cartilage. Matrilin-4, collagen XII, thrombospondin-4, fibronectin, βig-h3, and epiphycan are components of the in vivo collagen IX interactome. We applied a proteomics approach to advance our understanding of collagen IX ablation in cartilage. The cartilage extracellular matrix is essential for endochondral bone development and joint function. In addition to the major aggrecan/collagen II framework, the interacting complex of collagen IX, matrilin-3, and cartilage oligomeric matrix protein (COMP) is essential for cartilage matrix stability, as mutations in Col9a1, Col9a2, Col9a3, Comp, and Matn3 genes cause multiple epiphyseal dysplasia, in which patients develop early onset osteoarthritis. In mice, collagen IX ablation results in severely disturbed growth plate organization, hypocellular regions, and abnormal chondrocyte shape. This abnormal differentiation is likely to involve altered cell-matrix interactions but the mechanism is not known. To investigate the molecular basis of the collagen IX null phenotype we analyzed global differences in protein abundance between wild-type and knock-out femoral head cartilage by capillary HPLC tandem mass spectrometry. We identified 297 proteins in 3-day cartilage and 397 proteins in 21-day cartilage. Components that were differentially abundant between wild-type and collagen IX-deficient cartilage included 15 extracellular matrix proteins. Collagen IX ablation was associated with dramatically reduced COMP and matrilin-3, consistent with known interactions. Matrilin-1, matrilin-4, epiphycan, and thrombospondin-4 levels were reduced in collagen IX null cartilage, providing the first in vivo evidence for these proteins belonging to the collagen IX interactome. Thrombospondin-4 expression was reduced at the mRNA level, whereas matrilin-4 was verified as a novel collagen IX-binding protein. Furthermore, changes in TGFβ-induced protein βig-h3 and fibronectin abundance were found in the collagen IX knock-out but not associated with COMP ablation, indicating specific involvement in the abnormal collagen IX null cartilage. In addition, the more widespread expression of collagen XII in the collagen IX-deficient cartilage suggests an attempted compensatory response to the absence of collagen IX. Our differential proteomic analysis of cartilage is a novel approach to identify candidate matrix protein interactions in vivo, underpinning further analysis of mutant cartilage lacking other matrix components or harboring disease-causing mutations.

Defining the human deubiquitinating enzyme interaction landscape.

PubMed

Sowa, Mathew E; Bennett, Eric J; Gygi, Steven P; Harper, J Wade

2009-07-23

Deubiquitinating enzymes (Dubs) function to remove covalently attached ubiquitin from proteins, thereby controlling substrate activity and/or abundance. For most Dubs, their functions, targets, and regulation are poorly understood. To systematically investigate Dub function, we initiated a global proteomic analysis of Dubs and their associated protein complexes. This was accomplished through the development of a software platform called CompPASS, which uses unbiased metrics to assign confidence measurements to interactions from parallel nonreciprocal proteomic data sets. We identified 774 candidate interacting proteins associated with 75 Dubs. Using Gene Ontology, interactome topology classification, subcellular localization, and functional studies, we link Dubs to diverse processes, including protein turnover, transcription, RNA processing, DNA damage, and endoplasmic reticulum-associated degradation. This work provides the first glimpse into the Dub interaction landscape, places previously unstudied Dubs within putative biological pathways, and identifies previously unknown interactions and protein complexes involved in this increasingly important arm of the ubiquitin-proteasome pathway.

Defining the Human Deubiquitinating Enzyme Interaction Landscape

PubMed Central

Sowa, Mathew E.; Bennett, Eric J.; Gygi, Steven P.; Harper, J. Wade

2009-01-01

Summary Deubiquitinating enzymes (Dubs) function to remove covalently attached ubiquitin from proteins, thereby controlling substrate activity and/or abundance. For most Dubs, their functions, targets, and regulation are poorly understood. To systematically investigate Dub function, we initiated a global proteomic analysis of Dubs and their associated protein complexes. This was accomplished through the development of a software platform, called CompPASS, which uses unbiased metrics to assign confidence measurements to interactions from parallel non-reciprocal proteomic datasets. We identified 774 candidate interacting proteins associated with 75 Dubs. Using Gene Ontology, interactome topology classification, sub-cellular localization and functional studies, we link Dubs to diverse processes, including protein turnover, transcription, RNA processing, DNA damage, and endoplasmic reticulum-associated degradation. This work provides the first glimpse into the Dub interaction landscape, places previously unstudied Dubs within putative biological pathways, and identifies previously unknown interactions and protein complexes involved in this increasingly important arm of the ubiquitin-proteasome pathway. PMID:19615732

20180318 - Structure identification by Mass Spectrometry Non-Targeted Analysis using the US EPA’s CompTox Chemistry Dashboard (ACS Spring)

EPA Science Inventory

Identification of unknowns in mass spectrometry based non-targeted analyses (NTA) requires the integration of complementary pieces of data to arrive at a confident, consensus structure. Researchers use chemical reference databases, spectral matching, fragment prediction tools, r...

Freight distribution problems in congested urban areas : fast and effective solution procedures to time-dependent vehicle routing problems

DOT National Transportation Integrated Search

2011-01-01

Congestion is a common phenomenon in all medium to large cities of the world. Reliability of freight movement in urban areas is an important : issue to manufacturing or service companies whose operation is based in just-in-time approaches. These comp...

Retirement | Alaska Division of Retirement and Benefits

Science.gov Websites

Comp All Other Programs Features Empower Retirement Account Info Online myRnB Member Services Seminars Benefits > Retirement Online Counselor Scheduler Empower Retirement Account Info Online myRnB Member Welcome to the Retirement Section News Empower Increases Participant Account Security Help What retirement

Irradiation, microwave and alternative energy-based treatments for low water activity foods

USDA-ARS?s Scientific Manuscript database

There is an increasing recognition of low water activity foods as vectors for human pathogens. Partially or fully dried agricultural commodities, along with modern formulated dried food products, are complex, and designed to meet a variety of nutritional, sensory, and market-oriented goal. This comp...

First report of the post-fire morel, Morchella exuberans, in eastern North America

USDA-ARS?s Scientific Manuscript database

Reports of true morels (Morchella) fruiting on conifer burn sites are common in western North America where five different fire-adapted species of black morels (Elata Clade) have been documented based on multilocus phylogenetic analyses. Fruiting of post-fire morels in eastern North America, by comp...

ELUCIDATING THE ROLE OF ELECTRON TRANSFER MEDIATORS IN REDUCTIVE TRANSFORMATIONS IN NATURAL SEDIMENTS

EPA Science Inventory

To study the identity and reactivity of electron transfer mediators (ETMs) in natural sediments, the reduction kinetics of a glass bead-azo dye complex were measured in abiotic and biotic model systems, as well as in natural sediments. In abiotic model systems, the bead-dye comp...

32 CFR 272.1 - Purpose

Code of Federal Regulations, 2010 CFR

2010-07-01

... AND SUPPORT OF BASIC RESEARCH BY THE DEPARTMENT OF DEFENSE § 272.1 Purpose This part implements the: (a) Policy on the support of scientific research in Executive Order 10521, “Administration of Scientific Research by Agencies of the Federal Government” (3 CFR, 1954-1958 Comp., p. 183), as amended; and...

32 CFR 272.1 - Purpose

Code of Federal Regulations, 2011 CFR

2011-07-01

... AND SUPPORT OF BASIC RESEARCH BY THE DEPARTMENT OF DEFENSE § 272.1 Purpose This part implements the: (a) Policy on the support of scientific research in Executive Order 10521, “Administration of Scientific Research by Agencies of the Federal Government” (3 CFR, 1954-1958 Comp., p. 183), as amended; and...

OBSERVATIONS ON THE REGROWTH OF SUBAQUATIC VEGETATION FOLLOWING TRANSPLANTATION: A POTENTIAL METHOD TO ASSESS ENVIRONMENTAL HEALTH OF COASTAL HABITATS

EPA Science Inventory

In 1991, experimental transplantings of Vallisneria americana (tapegrass, vallisneria, or wildcelery) were initiated at selected sites which lacked grass beds along the north shore of Perdido Bay, located on the Alabama-Florida border. Abatement of organic and color-staining comp...

TRIBROMOPYRROLE, BROMINATED ACIDS, AND OTHER DISINFECTION BYPRODUCTS PRODUCED BY DISINFECTION OF DRINKING WATER RICH IN BROMIDE

EPA Science Inventory

Using gas chromatography/mass spectrometry (GC/MS), we investigated the formation of disinfection byproducts (DBPs) from high bromide waters (2 mg/L) treated with chlorine or chlorine dioxide used in combination with chlorine and chloramines. This study represents the first comp...

Comparison of Field Measurements to Methane Emissions Models at a New Landfill

EPA Science Inventory

Due to both technical and economic limitations, estimates of methane emissions from landfills rely primarily on models. While models are easy to implement, there is uncertainty due to the use of parameters that are difficult to validate. The objective of this research was to comp...

Expedient Repair Materials for Roadway Pavements

DTIC Science & Technology

2005-03-01

SILSPEC 900 PNS Patch/spall SSI Const. & Indus. Elastomeric conc. Matls Sikadur 22 Lo-Mod Sika Corp. Epoxy polymer concrete SikaTop 123 Plus Thin...patch Sika 2-component, polymer- 15 min modified Sikaset Roadway Patch Patch/spall Sika 1-comp. with high 15-25 min (15 min) (2000) alumina cement (not

Toward a More Comprehensive Model of Teacher Pay. Research Brief

ERIC Educational Resources Information Center

National Center on Performance Incentives, 2008

2008-01-01

In "Toward a More Comprehensive Model of Teacher Pay"--a paper presented at the February 2008 National Center on Performance Incentives research to policy conference--Julia Koppich examines recent policy initiatives implementing new approaches to teacher pay. Her discussion focuses on four current initiatives: ProComp in Denver, Toledo…

Measurement of Aerosolization of Asbestos from Soil Using the Releasable Asbestos Field Sampler (RAFS)

EPA Science Inventory

Releasable Asbestos Field Sampler (RAFS) was designed to provide an alternative to activity-based sampling (ABS) for determining likely asbestos exposure resulting from activities at site with low contaminant levels. This paper presents a description of the RAFS device and a comp...

A Multicultural Perspective on Play and Learning in Primary School

ERIC Educational Resources Information Center

Lillemyr, Ole Fredrik; Sobstad, Frode; Marder, Kurt; Flowerday, Terri

2011-01-01

In the school's conception of learning, the cultural aspect of children's play has often been lacking. In different countries, it is emphasized that play is important for learning (Dockett and Fleer, Play and pedagogy in early childhood: Bending the rules. Harcourt Brace & Comp, Sydney, "1999"; Lillemyr, Nordisk Pedagogik/Nordic…

Cumulative assessment of steroid receptor mediated activity of contaminants in water samples using in vitro bioassays. -EMGS

EPA Science Inventory

Cell-based in vitro assays show promise for water quality monitoring applications due to high sensitivity, the ability to quantitatively detect a biologically relevant effect endpoint such as receptor transactivation (i.e., effect-based monitoring), and the ability to assess comp...

Ohio Department of Transportation State Infrastructure Bank Annual Financial Report : Federal Fiscal Year 2004

DOT National Transportation Integrated Search

2004-01-01

The Ohio Department of Transportation is pleased to present the Federal Fiscal : Year 2004 State Infrastructure Bank (SIB) Annual Financial Report. The portfolio of : the FFY 04 SIB had a total of nineteen loans in the amount of $47,340,891. : A comp...

“httk”: EPA’s Tool for High Throughput Toxicokinetics (CompTox CoP)

EPA Science Inventory

Thousands of chemicals have been pro?led by high-throughput screening programs such as ToxCast and Tox21; these chemicals are tested in part because most of them have limited or no data on hazard, exposure, or toxicokinetics. Toxicokinetic models aid in predicting tissue concentr...

24 CFR 2002.21 - Authority to deny requests for records and form of denial.

Code of Federal Regulations, 2010 CFR

2010-04-01

... criminal investigation or by an agency conducting a lawful national security intelligence investigation... commercial or financial information, predisclosure notification to business submitters is required by Executive Order 12600 (3 CFR, 1987 Comp., p. 235) to afford the business submitter an opportunity to object...

Cross-Talk in Comp Theory: A Reader.

ERIC Educational Resources Information Center

Villanueva, Victor, Jr., Ed.

Intended for experienced teachers of composition and for graduate student of composition studies, this collection of essays represents an overview of the last 30 years of composition theory--a near chronology of the profession's changes, from process to cohesion to cognition to social construction to ideology. The 41 essays and their authors…

ANALYSIS OF THE ENANTIOMERS OF CHIRAL PESTICIDES AND OTHER POLLUTANTS IN ENVIRONMENTAL SAMPLES BY CAPILLARY ELECTROPHORESIS

EPA Science Inventory

The generic method described here involves typical capillary electrophoresis (CE) techniques, with the addition of cyclodextrin chiral selectors to the electrolyte for enantiomer separation and also, in the case of neutral analytes, the further addition of a micelle forming comp...

PROGRAM TO DETERMINE PERFORMANCE OF FLUORINATED ETHERS AND FLUORINATED PROPANES IN A COMPRESSOR CALORIMETER

EPA Science Inventory

The paper discusses a program to determine the performance of fluorinated ethers and fluorinated propanes in a compressor calorimeter. These chlorine free ethers and propanes are being considered as potential long-term replacements for CFC-11, -12, -114, and -115. A standard comp...

Determination of selection criteria for spray drift reduction from atomization data

USDA-ARS?s Scientific Manuscript database

When testing and evaluating drift reduction technologies (DRT), there are different metrics that can be used to determine if the technology reduces drift as compared to a reference system. These metrics can include reduction in percent of fine drops, measured spray drift from a field trial, or comp...

Acute sensitivity of freshwater mollusks and commonly tested invertebrates to select chemicals with different toxic models of action

EPA Science Inventory

Previous studies indicate that freshwater mollusks are more sensitive than commonly tested organisms to some chemicals, such as copper and ammonia. Nevertheless, mollusks are generally under-represented in toxicity databases. Studies are needed to generate data with which to comp...

25 CFR 225.24 - Environmental studies.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 40 CFR parts 1500-1508. (b) The Secretary shall ensure that all necessary surveys are performed and... 11593 (3 CFR 1971-1975 Comp., p. 559, May 13, 1971). If these surveys indicate that a mineral... effect is mitigated, or that appropriate excavations or other related research is conducted; and (3...

25 CFR 225.24 - Environmental studies.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 40 CFR parts 1500-1508. (b) The Secretary shall ensure that all necessary surveys are performed and... 11593 (3 CFR 1971-1975 Comp., p. 559, May 13, 1971). If these surveys indicate that a mineral... effect is mitigated, or that appropriate excavations or other related research is conducted; and (3...

25 CFR 225.24 - Environmental studies.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 40 CFR parts 1500-1508. (b) The Secretary shall ensure that all necessary surveys are performed and... 11593 (3 CFR 1971-1975 Comp., p. 559, May 13, 1971). If these surveys indicate that a mineral... effect is mitigated, or that appropriate excavations or other related research is conducted; and (3...

25 CFR 225.24 - Environmental studies.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 40 CFR parts 1500-1508. (b) The Secretary shall ensure that all necessary surveys are performed and... 11593 (3 CFR 1971-1975 Comp., p. 559, May 13, 1971). If these surveys indicate that a mineral... effect is mitigated, or that appropriate excavations or other related research is conducted; and (3...

Test using expansive cement in cement stabilized base to eliminate or prevent cracking : experimental projects.

DOT National Transportation Integrated Search

1975-08-01

The purpose of this study was to determine the feasibility of using an : expansive cement, TXI 4C Chem Comp, in lieu of the regular Type I Portland : Cement in a cement stabilized gravel screenings base so as to eliminate : or reduce cracks associate...

DSSTox: The Open Environmental Chemistry Data underlying the CompTox Chemical Dashboard (OpenTox USA)

EPA Science Inventory

The DSSTox project has long been dedicated to the idea of making chemical information linked to environmental or toxicological data of interest freely available. Since its first posting of data files in 2004, DSSTox database development has consistently focused on enabling data ...

From Dictatorship to Democracy: History of Education in Spain

ERIC Educational Resources Information Center

Viñao, Antonio

2014-01-01

In a book published in 1995 providing an overview on the state of the art in European educational historiography in Europe, Marie-Madeleine Compère referring to post-Franco Spain, emphasised the "dynamism" and "the capacity to mobilise" that had arisen among Spanish researchers by "any collective initiative." Moving…

PROJECTING POPULATION-LEVEL RESPONSES OF MYSIDS EXPOSED TO AN ENDOCRINE DISRUPTING CHEMICAL

EPA Science Inventory

Raimondo, Sandy and Charles L. McKenney, Jr. Submitted. Projecting Population-Level Responses of Mysids Exposed to an Endocrine-Disrupting Chemical. Integr. Comp. Biol. 23 p. (ERL,GB 1203).

To fully understand the implications of a chemical's effect on the conservation of...

Nitrous oxide emissions from a coal mine land reclaimed with stabilized manure

USDA-ARS?s Scientific Manuscript database

Mined land restoration using manure-based amendments may create soil conditions suitable for nitrous oxide production and emission. We measured nitrous oxide emissions from mine soil amended with composted poultry manure (Comp) or poultry manure mixed with paper mill sludge (Man+PMS) at C/N ratios o...

Controls of event-based nutrient transport within nested headwater agricultural watersheds of the western Lake Erie basin

USDA-ARS?s Scientific Manuscript database

Understanding the processes controlling nutrient delivery in headwater agricultural watersheds is essential for predicting and mitigating eutrophication and harmful algal blooms in receiving surface waters. The objective of this study was to elucidate nutrient transport pathways and examine key comp...

Computer Service Technician "COMPS." Curriculum Grant 1985.

ERIC Educational Resources Information Center

Schoolcraft Coll., Livonia, MI.

This document is a curriculum guide for a program in computer service technology developed at Schoolcraft College, Livonia, Michigan. The program is designed to give students a strong background in the fundamentals of electricity, electronic devices, and basic circuits (digital and linear). The curriculum includes laboratory demonstrations of the…

77 FR 52025 - Notification of a Public Teleconference of the Science Advisory Board; Exposure and Human Health...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-28

... Science Advisory Board; Exposure and Human Health Committee AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: The Environmental Protection Agency (EPA) Science Advisory Board (SAB) Staff... draft report concerning EPA's application of computational toxicology (CompTox) data in risk assessment...

Managing Parallelism and Resources in Scientific Dataflow Programs

DTIC Science & Technology

1990-03-01

1983. [52] K. Hiraki , K. Nishida, S. Sekiguchi, and T. Shimada. Maintainence architecture and its LSI implementation of a dataflow computer with a... Hiraki , and K. Nishida. An architecture of a data flow machine and its evaluation. In Proceedings of CompCon 84, pages 486-490. IEEE, 1984. [84] N

Effect of hydrocolloids on functional properties of navy bean starch

USDA-ARS?s Scientific Manuscript database

Pulses are recognized as a low-fat source of gluten-free protein, soluble fiber, B-vitamins and minerals, and their use in foods has increased in recent years. The functional properties of pulse starches have received relatively little attention, but they are important since starch is the major comp...

Building Program Verifiers from Compilers and Theorem Provers

DTIC Science & Technology

2015-05-14

Checking with SMT UFO • LLVM-based front-end (partially reused in SeaHorn) • Combines Abstract Interpretation with Interpolation-Based Model Checking • (no...assertions Counter-examples are long Hard to determine (from main) what is relevant Assertion Main 35 Building Verifiers from Comp and SMT Gurfinkel, 2015

Auftragstaktik: The Basis for Modern Military Command?

DTIC Science & Technology

2012-12-06

Operations of the Second Army from the Opening of the Campaign to the Capitulation of Metz, comp. Captain von der Goltz (Berlin: E. S. Mittler...from the Opening of the Campaign to the Capitulation of Metz. Compiled by Captain von der Goltz . Berlin: E.S. Mittler & Son, 1873. Hoenig, Fritz. La

Aerostat-Based Sampling of Emissions from Open Burning and Open Detonation of Military Ordnance

EPA Science Inventory

Emissions from open detonation (OD), open burning (OB), and static firing (SF) of obsolete military munitions were collected using an aerostat-lofted sampling instrument maneuvered into the plumes with remotely controlled tether winches. PM2.5, PM10, metals, volatile organic comp...

A Comprehensive High Performance Predictive Tool for Fusion Liquid Metal Hydromagnetics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Peter; Chhabra, Rupanshi; Munipalli, Ramakanth

In Phase I SBIR project, HyPerComp and Texcel initiated the development of two induction-based MHD codes as a predictive tool for fusion hydro-magnetics. The newly-developed codes overcome the deficiency of other MHD codes based on the quasi static approximation by defining a more general mathematical model that utilizes the induced magnetic field rather than the electric potential as the main electromagnetic variable. The UCLA code is a finite-difference staggered-mesh code that serves as a supplementary tool to the massively-parallel finite-volume code developed by HyPerComp. As there is no suitable experimental data under blanket-relevant conditions for code validation, code-to-code comparisons andmore » comparisons against analytical solutions were successfully performed for three selected test cases: (1) lid-driven MHD flow, (2) flow in a rectangular duct in a transverse magnetic field, and (3) unsteady finite magnetic Reynolds number flow in a rectangular enclosure. The performed tests suggest that the developed codes are accurate and robust. Further work will focus on enhancing the code capabilities towards higher flow parameters and faster computations. At the conclusion of the current Phase-II Project we have completed the preliminary validation efforts in performing unsteady mixed-convection MHD flows (against limited data that is currently available in literature), and demonstrated flow behavior in large 3D channels including important geometrical features. Code enhancements such as periodic boundary conditions, unmatched mesh structures are also ready. As proposed, we have built upon these strengths and explored a much increased range of Grashof numbers and Hartmann numbers under various flow conditions, ranging from flows in a rectangular duct to prototypic blanket modules and liquid metal PFC. Parametric studies, numerical and physical model improvements to expand the scope of simulations, code demonstration, and continued validation activities have also been completed.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harvey, R. W.

This DOE grant supported fusion energy research, a potential long-term solution to the world's energy needs. Magnetic fusion, exemplified by confinement of very hot ionized gases, i.e., plasmas, in donut-shaped tokamak vessels is a leading approach for this energy source. Thus far, a mixture of hydrogen isotopes has produced 10's of megawatts of fusion power for seconds in a tokamak reactor at Princeton Plasma Physics Laboratory in New Jersey. The research grant under consideration, ER54684, uses computer models to aid in understanding and projecting efficacy of heating and current drive sources in the National Spherical Torus Experiment, a tokamak variant,more » at PPPL. The NSTX experiment explores the physics of very tight aspect ratio, almost spherical tokamaks, aiming at producing steady-state fusion plasmas. The current drive is an integral part of the steady-state concept, maintaining the magnetic geometry in the steady-state tokamak. CompX further developed and applied models for radiofrequency (rf) heating and current drive for applications to NSTX. These models build on a 30 year development of rf ray tracing (the all-frequencies GENRAY code) and higher dimensional Fokker-Planck rf-collisional modeling (the 3D collisional-quasilinear CQL3D code) at CompX. Two mainline current-drive rf modes are proposed for injection into NSTX: (1) electron Bernstein wave (EBW), and (2) high harmonic fast wave (HHFW) modes. Both these current drive systems provide a means for the rf to access the especially high density plasma--termed high beta plasma--compared to the strength of the required magnetic fields. The CompX studies entailed detailed modeling of the EBW to calculate the efficiency of the current drive system, and to determine its range of flexibility for driving current at spatial locations in the plasma cross-section. The ray tracing showed penetration into NSTX bulk plasma, relatively efficient current drive, but a limited ability to produce current over the whole radial plasma cross-section. The actual EBW experiment will cost several million dollars, and remains in the proposal stage. The HHFW current drive system has been experimentally implemented on NSTX, and successfully drives substantial current. The understanding of the experiment is to be accomplished in terms of general concepts of rf current drive, and also detailed modeling of the experiment which can discern the various competing processes which necessarily occur simultaneously in the experiment. An early discovery of the CompX codes, GENRAY and CQL3D, was that there could be significant interference between the neutral beam injection fast ions in the machine (injected for plasma heating) and the HHFW energy. Under many NSTX experimental conditions, power which could go to the fast ions would then be unavailable for current drive by the desired HHFW interaction with electrons. This result has been born out by experiments; the modeling helps in understanding difficulties with HHFW current drive, and has enabled adjustment of the experiment to avoid interaction with neutral beam injected fast ions thereby achieving stronger HHFW current drive. The detailed physics modeling of the various competing processes is almost always required in fusion energy plasma physics, to ensure a reasonably accurate and certain interpretation of the experiment, enabling the confident design of future, more advanced experiments and ultimately a commercial fusion reactor. More recent work entails detailed investigation of the interaction of the HHFW radiation for fast ions, accounting for the particularly large radius orbits in NSTX, and correlations between multiple HHFW-ion interactions. The spherical aspect of the NSTX experiment emphasized particular physics such as the large orbits which are present to some degree in all tokamaks, but gives clearer clues on the resulting physics phenomena since competing physics effects are reduced.« less

24 CFR 50.1 - Purpose, authority, and applicability.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Purpose, authority, and..., restoring and enhancing environmental quality. NEPA is implemented by Executive Order 11514 of March 5, 1970, (3 CFR, 1966-1970 Comp., p. 902) as amended by Executive Order 11991 of May 24, 1977, (3 CFR, 1977...

The Role of Edited Collections in Composition Studies.

ERIC Educational Resources Information Center

Micciche, Laura

2001-01-01

Describes general characteristics of edited collections and then offers a brief history of the genre in composition studies based in part on the existing data in CompPile, an online and ongoing bibliography. Explores several explanations for the proliferation of edited collections in the field. Makes note of what these explanations can say about…

Background, College Experiences, and the ACT-COMP Exam: Using Construct Validity to Evaluate Assessment Instruments.

ERIC Educational Resources Information Center

Pike, Gary R.

1989-01-01

A study investigated the appropriateness of the American College Testing Program's College Outcome Measures Program, conducted at the University of Tennessee, Knoxville, by applying the criterion of construct validity. Results indicated that while the test primarily measures individual differences, it is also sensitive to the effects of higher…

Topoclimatic aspects of developmental suitability in the metropolitan landscape

Treesearch

Spencer A., Jr. Joyner; Raymond S. Bradley; Robert E., Jr. Reiter

1977-01-01

A computer-based procedure for geographically identifying rating, and ranking topoclimatic characteristics is described. The influences of topography, land use, and soils are considered and combined into a single composite topoclimate developmental suitability map drawn by a Cal Comp plotter. By allocating development to the most suitable topoclimate areas, the long-...

Characterization of two biologically distinct variants of Tomato spotted wilt virus

USDA-ARS?s Scientific Manuscript database

Significant economic losses result on a wide range of crops due to infection with Tomato spotted wilt virus (TSWV). In this study, two TSWV isolates, one from basil and a second from tomato, were established in a common plant host. Viral proteins were monitored over time, plant host ranges were comp...

34 CFR 85.415 - What must I do if a Federal agency excludes the participant or a principal after I enter into a...

Code of Federal Regulations, 2010 CFR

2010-07-01

... after you learn of the exclusion or after the close of the Federal fiscal year in which the exclusion takes effect, whichever is later. Authority: E.O. 12549 (3 CFR, 1986 Comp., p. 189); E.O 12689 (3 CFR...

Effect of foliar application of pyrifluquinazon on Bemisia tabaci (MED whitefly) and Amblyseius swirskii, 2016

USDA-ARS?s Scientific Manuscript database

With the overall goal to integrate the predatory mite Amblyseius swirskii in the management program of MED whitefly, the specific objective of this study was to evaluate pyrifluquinazon, a pyridine insecticide for whitefly control, and assess its compatibility with swirskii mite, and assess its comp...

Autonomous Underwater Munitions and Explosives of Concern Detection System

DTIC Science & Technology

2015-03-01

Field Magnetometer ......................................................................... 19 5.3.2 Fluxgate Compass...through the vehicle control system. Magnetic measurements are sampled at 10 Hz. 5.3.2 Fluxgate Compass Located in the magnetometer module pressure...pitch, and roll) from the fluxgate compass and the total field magnetometer measurements are required for processing into the MagComp compensation

CompGC: Efficient Offline/Online Sem i-honest Two-party Computation

DTIC Science & Technology

2016-04-22

Rivest, and A. T. Sherman, Eds., Plenum Press, New York, USA, pp. 205–210. 13 [9] Goldreich, O. Foundations of Cryptography : Volume 2, Basic...low depth circuits. In FC 2013: 17th International Conference on Financial Cryptography and Data Security (Okinawa, Japan, Apr. 1–5, 2013), A.-R

The Reintegration of Tongan Postgraduate Scholars after Study Abroad: Knowledge Utilisation and Resituation

ERIC Educational Resources Information Center

Franken, Margaret; Langi, Nautalus Tuituiovai Kaho; Branson, Christopher

2016-01-01

Higher education has seen increasing educational mobility as students finance themselves or get financial support from their families to study abroad (Shields "Comp Educ Rev" 57(4):609-636, 2013; Verbik and Lazanowski in "World education news and reviews." http://www.wes.org/educators/pdf/StudentMobility.pdf, 2007). Another…

Digital Competence Model of Distance Learning Students

ERIC Educational Resources Information Center

da Silva, Ketia Kellen A.; Behar, Patricia A.

2017-01-01

This article presents the development of a digital competency model of Distance Learning (DL) students in Brazil called CompDigAl_EAD. The following topics were addressed in this study: Educational Competences, Digital Competences, and Distance Learning students. The model was developed between 2015 and 2016 and is being validated in 2017. It was…

32 CFR 22.530 - Metric system of measurement.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Metric system of measurement. 22.530 Section 22... REGULATIONS DoD GRANTS AND AGREEMENTS-AWARD AND ADMINISTRATION National Policy Matters § 22.530 Metric system... CFR, 1991 Comp., p. 343), states that: (1) The metric system is the preferred measurement system for U...

32 CFR 22.530 - Metric system of measurement.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 1 2014-07-01 2014-07-01 false Metric system of measurement. 22.530 Section 22... REGULATIONS DoD GRANTS AND AGREEMENTS-AWARD AND ADMINISTRATION National Policy Matters § 22.530 Metric system... CFR, 1991 Comp., p. 343), states that: (1) The metric system is the preferred measurement system for U...

32 CFR 22.530 - Metric system of measurement.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false Metric system of measurement. 22.530 Section 22... REGULATIONS DoD GRANTS AND AGREEMENTS-AWARD AND ADMINISTRATION National Policy Matters § 22.530 Metric system... CFR, 1991 Comp., p. 343), states that: (1) The metric system is the preferred measurement system for U...

32 CFR 22.530 - Metric system of measurement.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Metric system of measurement. 22.530 Section 22... REGULATIONS DoD GRANTS AND AGREEMENTS-AWARD AND ADMINISTRATION National Policy Matters § 22.530 Metric system... CFR, 1991 Comp., p. 343), states that: (1) The metric system is the preferred measurement system for U...

32 CFR 22.530 - Metric system of measurement.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false Metric system of measurement. 22.530 Section 22... REGULATIONS DoD GRANTS AND AGREEMENTS-AWARD AND ADMINISTRATION National Policy Matters § 22.530 Metric system... CFR, 1991 Comp., p. 343), states that: (1) The metric system is the preferred measurement system for U...

The Heartland Region P-Index Conservation Innovation Grant: protecting water quality through improved phosphorus management

USDA-ARS?s Scientific Manuscript database

Reducing phosphorus loss from agricultural land is important for improvement and protection of surface water quality. Agricultural models can be used to determine management impacts on P loss and therefore serve as a guide for recommending best management practices. However, the models must be comp...

48 CFR 22.403-4 - Department of Labor regulations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Department of Labor... 22.403 and Reorganization Plan No. 14 of 1950 (3 CFR 1949-53 Comp., p. 1007), the Secretary of Labor..., Feb. 18, 1988, as amended at 66 FR 2141, Jan. 10, 2001; 66 FR 53480, Oct. 22, 2001] ...

An Exchange between Laurie Grobman and Richard C. Raymond

ERIC Educational Resources Information Center

Teaching English in the Two-Year College, 2010

2010-01-01

This article presents a commentary exchange between authors Laurie Grobman and Richard C. Raymond regarding Raymond's article "Re-placing Lit in Comp II: Pragmatic/Humanistic Benefits." Grobman said that in her brief commentary on Raymond's article, she chooses not to explicitly address his thesis that literature belongs in a research-based…

34 CFR 668.82 - Standard of conduct.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) Upon learning of a conviction, plea, or administrative or judicial determination described in paragraph.... 12549 (3 CFR, 1986 Comp., p. 189) or the FAR, 48 CFR part 9, subpart 9.4; and (ii) Upon learning of the... period of 60 days, beginning on the effective date specified in the notice by the Secretary under 2 CFR...

Free online access to experimental and predicted chemical properties through the EPA’s CompTox Chemistry Dashboard (ACS Spring meeting)

EPA Science Inventory

The increasing number and size of public databases is facilitating the collection of chemical structures and associated experimental data for QSAR modeling. However, the performance of QSAR models is highly dependent not only on the modeling methodology, but also on the quality o...

76 FR 14691 - Notice of Determinations Regarding Eligibility To Apply for Worker Adjustment Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-17

... domestic industry in an investigation resulting in-- (A) an affirmative determination of serious injury or..., Byron Center, MI....... December 16, 2009. CompX Durislide; Leased Workers from Gill Staffing, Manpower... Enterprises, Leased Workers Manpower, etc. 75,070 St. Johnson Medical Services Bethpage, NY January 5, 2010...

Identifying "known unknowns": A comparison between ChemSpider and the US EPA's CompTox Dashboard (ACS Spring National meeting) 1 of 7

EPA Science Inventory

Non-targeted analysis (NTA) workflows in high-resolution mass spectrometry require mechanisms for compound identification. One strategy for tentative identification is the use of online chemical databases such as ChemSpider. Databases like this use molecular formulae and monois...

Computer Software for Life Cycle Cost.

DTIC Science & Technology

1987-04-01

34 111. 1111I .25 IL4 jj 16 MICROCOPY RESOLUTION TEST CHART hut FILE C AIR CoMMNAMN STFF COLLG STUJDET PORTO i COMpUTER SOFTWARE FOR LIFE CYCLE CO879...obsolete), physical life (utility before physically wearing out), or application life (utility in a given function)." (7:5) The costs are usually

Structure identification for Non-Targeted Analytical Chemistry using the US EPA’s CompTox Chemistry Dashboard (ACS 2017 Fall meeting 3 of 3)

EPA Science Inventory

Identification of unknowns in non-targeted analyses (NTA) requires the integration of complementary data types to generate a confident consensus structure. Researchers use a variety of data and tools (e.g., chemical reference databases, spectral matching, fragment prediction too...

A CompStat Counterterrorism Strategy to Protect Train and Subway Systems

DTIC Science & Technology

2008-03-01

other aspect of this collection of information, including suggestions for reducing this burden, to Washington headquarters Services , Directorate for...Explosives on the London Underground .........................................54 VI. RECOVERY ...evacuation plan in an effort to aid in the recovery from an attack. This is essential in preventing the terrorists from accomplishing their goals of

34 CFR 85.415 - What must I do if a Federal agency excludes the participant or a principal after I enter into a...

Code of Federal Regulations, 2011 CFR

2011-07-01

... after you learn of the exclusion or after the close of the Federal fiscal year in which the exclusion takes effect, whichever is later. (Authority: E.O. 12549 (3 CFR, 1986 Comp., p. 189); E.O 12689 (3 CFR...

24 CFR 58.5 - Related Federal laws and authorities.

Code of Federal Regulations, 2012 CFR

2012-04-01

...). (2) Executive Order 11593, Protection and Enhancement of the Cultural Environment, May 13, 1971 (36... section 3 (16 U.S.C. 469a-1). (b) Floodplain management and wetland protection. (1) Executive Order 11988...) Executive Order 11990, Protection of Wetlands, May 24, 1977 (42 FR 26961), 3 CFR, 1977 Comp., p. 121...

24 CFR 58.5 - Related Federal laws and authorities.

Code of Federal Regulations, 2010 CFR

2010-04-01

...). (2) Executive Order 11593, Protection and Enhancement of the Cultural Environment, May 13, 1971 (36... section 3 (16 U.S.C. 469a-1). (b) Floodplain management and wetland protection. (1) Executive Order 11988...) Executive Order 11990, Protection of Wetlands, May 24, 1977 (42 FR 26961), 3 CFR, 1977 Comp., p. 121...

10 CFR Appendix A to Part 600 - Generally Applicable Requirements

Code of Federal Regulations, 2010 CFR

2010-01-01

... Competitive Practices Act of 1974 (49 U.S.C. 1517). Executive Order 12138, “Creating a National Women's... National Program for Women's Business Enterprise,” (May 18, 1979) 3 CFR 1979 Comp., p. 393. Sec. 403(b... Audit at Educational Institutions. OMB Circular A-73, Audit of Federal Operations and Programs. Single...

Teacher Performance Pay Programs and Necessary Communication Actions

ERIC Educational Resources Information Center

Heneman, Herbert G., III; Worth, Robin; Arrigoni, Jessica; Kimball, Steven M.; Milanowski, Anthony

2013-01-01

Teacher performance pay programs have proliferated across the country over the past 20 years. To aid in understanding their many variations, the seven major components of these programs are described. Three examples of teacher performance pay programs are provided for illustration: Denver ProComp, TAP, and Houston ASPIRE. Evidence is mixed on the…

Filth fly transmission of Escherichia coli O157:H7 and Salmonella enterica to lettuce, Lactuca sativa

USDA-ARS?s Scientific Manuscript database

Filth flies have been implicated in the dispersal of human disease pathogens; however, fly transmission parameters of human pathogens to plants are largely undescribed. The capacity of the black blow fly, Phormia regina, to acquire and subsequently release bacteria onto baby lettuce leaves was comp...

22 CFR 92.70 - Special fees for depositions in connection with foreign documents.

Code of Federal Regulations, 2010 CFR

2010-04-01

... and 3496, and E.O. 10307, 3 CFR, 1949-1953 Comp.). (c) Fees payable to interpreters and translators. Each interpreter and translator employed by the commissioner under these regulations shall receive an... interpreters and translators shall be chargeable to the United States. (d) Time for paying fees. Witnesses...

Intercomparison of measurements of NO2 concentrations in the atmosphere simulation chamber SAPHIR during the NO3Comp campaign

NASA Astrophysics Data System (ADS)

Fuchs, H.; Ball, S. M.; Bohn, B.; Brauers, T.; Cohen, R. C.; Dorn, H.-P.; Dubé, W. P.; Fry, J. L.; Häseler, R.; Heitmann, U.; Jones, R. L.; Kleffmann, J.; Mentel, T. F.; Müsgen, P.; Rohrer, F.; Rollins, A. W.; Ruth, A. A.; Kiendler-Scharr, A.; Schlosser, E.; Shillings, A. J. L.; Tillmann, R.; Varma, R. M.; Venables, D. S.; Villena Tapia, G.; Wahner, A.; Wegener, R.; Wooldridge, P. J.; Brown, S. S.

2010-01-01

NO2 concentrations were measured by various instruments during the NO3Comp campaign at the atmosphere simulation chamber SAPHIR at Forschungszentrum Jülich, Germany, in June 2007. Analytical methods included photolytic conversion with chemiluminescence (PC-CLD), broadband cavity ring-down spectroscopy (BBCRDS), pulsed cavity ring-down spectroscopy (CRDS), incoherent broadband cavity-enhanced absorption spectroscopy (IBBCEAS), and laser-induced fluorescence (LIF). All broadband absorption spectrometers were optimized for the detection of the main target species of the campaign, NO3, but were also capable of detecting NO2 simultaneously with reduced sensitivity. NO2 mixing ratios in the chamber were within a range characteristic of polluted, urban conditions, with a maximum mixing ratio of approximately 75 ppbv. The overall agreement between measurements of all instruments was excellent. Linear fits of the combined data sets resulted in slopes that differ from unity only within the stated uncertainty of each instrument. Possible interferences from species such as water vapor and ozone were negligible under the experimental conditions.

Intercomparison of measurements of NO2 concentrations in the atmosphere simulation chamber SAPHIR during the NO3Comp campaign

NASA Astrophysics Data System (ADS)

Fuchs, H.; Ball, S. M.; Bohn, B.; Brauers, T.; Cohen, R. C.; Dorn, H.-P.; Dubé, W. P.; Fry, J. L.; Häseler, R.; Heitmann, U.; Jones, R. L.; Kleffmann, J.; Mentel, T. F.; Müsgen, P.; Rohrer, F.; Rollins, A. W.; Ruth, A. A.; Kiendler-Scharr, A.; Schlosser, E.; Shillings, A. J. L.; Tillmann, R.; Varma, R. M.; Venables, D. S.; Villena Tapia, G.; Wahner, A.; Wegener, R.; Wooldridge, P. J.; Brown, S. S.

2009-10-01

NO2 concentrations were measured by various instruments during the NO3Comp campaign at the atmosphere simulation chamber SAPHIR at Forschungszentrum Jülich, Germany, in June 2007. Analytic methods included photolytic conversion with chemiluminescence (PC-CLD), broadband cavity ring-down spectroscopy (BBCRDS), pulsed cavity ring-down spectroscopy (CRDS), incoherent broadband cavity-enhanced absorption spectroscopy (IBBCEAS), and laser-induced fluorescence (LIF). All broadband absorption spectrometers were optimized for the detection of the main target species of the campaign, NO2, but were also capable of detecting NO2 simultaneously with reduced sensitivity. NO2 mixing ratios in the chamber were within a range characteristic of polluted, urban conditions, with a maximum mixing ratio of approximately 75 ppbv. The overall agreement between measurements of all instruments was excellent. Linear fits of the combined data sets resulted in slopes that differ from unity only within the stated uncertainty of each instrument. Possible interferences from species such as water vapor and ozone were negligible under the experimental conditions.

Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network

PubMed Central

Blank, Birgit; Maiser, Andreas; Emin, Derya; Prescher, Jens; Beck, Gisela; Kienzle, Christine; Bartnik, Kira; Habermann, Bianca; Pakdel, Mehrshad; Leonhardt, Heinrich; Lamb, Don C.

2016-01-01

Sorting and export of transmembrane cargoes and lysosomal hydrolases at the trans-Golgi network (TGN) are well understood. However, elucidation of the mechanism by which secretory cargoes are segregated for their release into the extracellular space remains a challenge. We have previously demonstrated that, in a reaction that requires Ca2+, the soluble TGN-resident protein Cab45 is necessary for the sorting of secretory cargoes at the TGN. Here, we report that Cab45 reversibly assembles into oligomers in the presence of Ca2+. These Cab45 oligomers specifically bind secretory proteins, such as COMP and LyzC, in a Ca2+-dependent manner in vitro. In intact cells, mutation of the Ca2+-binding sites in Cab45 impairs oligomerization, as well as COMP and LyzC sorting. Superresolution microscopy revealed that Cab45 colocalizes with secretory proteins and the TGN Ca2+ pump (SPCA1) in specific TGN microdomains. These findings reveal that Ca2+-dependent changes in Cab45 mediate sorting of specific cargo molecules at the TGN. PMID:27138253

Structure-based virtual screening efforts against HIV-1 reverse transcriptase to introduce the new potent non-nucleoside reverse transcriptase inhibitor

NASA Astrophysics Data System (ADS)

Hosseini, Yaser; Mollica, Adriano; Mirzaie, Sako

2016-12-01

The human immunodeficiency virus (HIV) which is strictly related to the development of AIDS, is treated by a cocktail of drugs, but due its high propensity gain drug resistance, the rational development of new medicine is highly desired. Among the different mechanism of action we selected the reverse transcriptase (RT) inhibition, for our studies. With the aim to identify new chemical entities to be used for further rational drug design, a set of 3000 molecules from the Zinc Database have been screened by docking experiments using AutoDock Vina software. The best ranked compounds with respect of the crystallographic inhibitor MK-4965 resulted to be five compounds, and the best among them was further tested by molecular dynamics (MD) simulation. Our results indicate that comp1 has a stronger interaction with the subsite p66 of RT than MK-4965 and that both are able to stabilize specific conformational changes of the RT 3D structure, which may explain their activity as inhibitors. Therefore comp1 could be a good candidate for biological tests and further development.

De Novo Assembly of a Transcriptome for Calanus finmarchicus (Crustacea, Copepoda) – The Dominant Zooplankter of the North Atlantic Ocean

PubMed Central

Lenz, Petra H.; Roncalli, Vittoria; Hassett, R. Patrick; Wu, Le-Shin; Cieslak, Matthew C.; Hartline, Daniel K.; Christie, Andrew E.

2014-01-01

Assessing the impact of global warming on the food web of the North Atlantic will require difficult-to-obtain physiological data on a key copepod crustacean, Calanus finmarchicus. The de novo transcriptome presented here represents a new resource for acquiring such data. It was produced from multiplexed gene libraries using RNA collected from six developmental stages: embryo, early nauplius (NI-II), late nauplius (NV-VI), early copepodite (CI-II), late copepodite (CV) and adult (CVI) female. Over 400,000,000 paired-end reads (100 base-pairs long) were sequenced on an Illumina instrument, and assembled into 206,041 contigs using Trinity software. Coverage was estimated to be at least 65%. A reference transcriptome comprising 96,090 unique components (“comps”) was annotated using Blast2GO. 40% of the comps had significant blast hits. 11% of the comps were successfully annotated with gene ontology (GO) terms. Expression of many comps was found to be near zero in one or more developmental stages suggesting that 35 to 48% of the transcriptome is “silent” at any given life stage. Transcripts involved in lipid biosynthesis pathways, critical for the C. finmarchicus life cycle, were identified and their expression pattern during development was examined. Relative expression of three transcripts suggests wax ester biosynthesis in late copepodites, but triacylglyceride biosynthesis in adult females. Two of these transcripts may be involved in the preparatory phase of diapause. A key environmental challenge for C. finmarchicus is the seasonal exposure to the dinoflagellate Alexandrium fundyense with high concentrations of saxitoxins, neurotoxins that block voltage-gated sodium channels. Multiple contigs encoding putative voltage-gated sodium channels were identified. They appeared to be the result of both alternate splicing and gene duplication. This is the first report of multiple NaV1 genes in a protostome. These data provide new insights into the transcriptome and physiology of this environmentally important zooplankter. PMID:24586345

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trouille, L.; Barger, A. J.; Tremonti, C.

The Baldwin, Phillips, and Terlevich emission-line ratio diagnostic ([O III]/H{beta} versus [N II]/H{alpha}, hereafter BPT diagram) efficiently separates galaxies whose signal is dominated by star formation (BPT-SF) from those dominated by active galactic nucleus (AGN) activity (BPT-AGN). Yet this BPT diagram is limited to z < 0.5, the redshift at which [N II]{lambda}6584 leaves the optical spectral window. Using the Sloan Digital Sky Survey (SDSS), we construct a new diagnostic, or TBT diagram, that is based on rest-frame g - z color, [Ne III]{lambda}3869, and [O II]{lambda}{lambda}3726 + 3729 and can be used for galaxies out to z < 1.4.more » The TBT diagram identifies 98.7% of the SDSS BPT-AGN as TBT-AGN and 97% of the SDSS BPT-SF as TBT-SF. Furthermore, it identifies 97% of the OPTX Chandra X-ray-selected AGNs as TBT-AGN. This is in contrast to the BPT diagram, which misidentifies 20% of X-ray-selected AGNs as BPT-SF. We use the Great Observatories Origins Deep Survey North and Lockman Hole galaxy samples, with their accompanying deep Chandra imaging, to perform X-ray and infrared stacking analyses to further validate our TBT-AGN and TBT-SF selections; that is, we verify the dominance of AGN activity in the former and star formation activity in the latter. Finally, we address the inclusion of the majority of the BPT-comp (sources lying between the BPT-SF and BPT-AGN regimes) in our TBT-AGN regime. We find that the stacked BPT-comp source is X-ray hard (({Gamma}{sub eff}) = 1.0{sup +0.4}{sub -0.4}) and has a high X-ray luminosity to total infrared luminosity ratio. This suggests that, on average, the X-ray signal in BPT-comp is dominated by obscured or low accretion rate AGN activity rather than by star formation, supporting their inclusion in the TBT-AGN regime.« less

Evolving prevalence of haematological malignancies in orphan designation procedures in the European Union.

PubMed

Polsinelli, Benedetta; Tsigkos, Stelios; Naumann-Winter, Frauke; Mariz, Segundo; Sepodes, Bruno

2017-01-21

The Committee for Orphan Medicinal Products (COMP) evaluates prevalence of rare conditions as one of the criteria for granting an orphan designation with a prevalence threshold of 5 in 10.000. At the time of Marketing Authorisation (MA) these criteria are reassessed to ensure they are still met. The COMP has noted discordance between the prevalence of certain haematological malignancies at the time of Orphan Designation and at the time of Marketing Authorisation. Consequently, we conducted a retrospective assessment of Chronic Lymphocytic Lymphoma and Multiple Myeloma/Plasma cell Myeloma as well as several other haematological rare aetiologies frequently subject of orphan designation. These were: Diffuse large B-Cell Lymphoma (DLBCL), Follicular Lymphoma (FL), Cutaneous T-Cell Lymphoma (CTCL), Mantle Cell Lymphoma (MCL) and Chronic Myeloid Leukaemia (CML). The review used submissions as well as recent publications and results from external and EMA databases. As a first step in the analysis, an increase over time in the number of people affected was evident for four conditions in the COMP designation documents, whereas for DLBCL, FL, CTCL and MCL there had been no significant change, since the introduction of the Regulation in 2000. Specifically, the prevalence estimates increased from 1.2 to 3.6 per 10,000 for multiple myeloma, from 0.4 to 1.7 in acute lymphoblastic leukaemia, and from 2.7 to 4.85 for chronic lymphocytic leukaemia/small lymphocytic leukaemia and 1 to 2 in 10,000 for chronic myeloid leukaemia. The reasons for the changes in the prevalence of these four haematological conditions over the last 15 years were not assessed but recent publications have alluded to better outcomes due to new treatments being made available. In addition, many orphan diseases have a median age of onset over 60 years so that also the aging of the population may be a relevant contributing factor.

Turbulence and Heating in the Flank and Wake Regions of a Coronal Mass Ejection

NASA Astrophysics Data System (ADS)

Fan, Siteng; He, Jiansen; Yan, Limei; Tomczyk, Steven; Tian, Hui; Song, Hongqiang; Wang, Linghua; Zhang, Lei

2018-01-01

As a coronal mass ejection (CME) passes, the flank and wake regions are typically strongly disturbed. Various instruments, including the Large Angle and Spectroscopic Coronagraph (LASCO), the Atmospheric Imaging Assembly (AIA), and the Coronal Multi-channel Polarimeter (CoMP), observed a CME close to the east limb on 26 October 2013. A hot ({≈} 10 MK) rising blob was detected on the east limb, with an initial ejection flow speed of {≈} 330 km s^{-1}. The magnetic structures on both sides and in the wake of the CME were strongly distorted, showing initiation of turbulent motions with Doppler-shift oscillations enhanced from {≈} ± 3 km s^{-1} to {≈} ± 15 km s^{-1} and effective thermal velocities from {≈} 30 km s^{-1} to {≈} 60 km s^{-1}, according to the CoMP observations at the Fe xiii line. The CoMP Doppler-shift maps suggest that the turbulence behaved differently at various heights; it showed clear wave-like torsional oscillations at lower altitudes, which are interpreted as the antiphase oscillation of an alternating red/blue Doppler shift across the strands at the flank. The turbulence seems to appear differently in the channels of different temperatures. Its turnover time was {≈} 1000 seconds for the Fe 171 Å channel, while it was {≈} 500 seconds for the Fe 193 Å channel. Mainly horizontal swaying rotations were observed in the Fe 171 Å channel, while more vertical vortices were seen in the Fe 193 Å channel. The differential-emission-measure profiles in the flank and wake regions have two components that evolve differently: the cool component decreased over time, evidently indicating a drop-out of cool materials due to ejection, while the hot component increased dramatically, probably because of the heating process, which is suspected to be a result of magnetic reconnection and turbulence dissipation. These results suggest a new turbulence-heating scenario of the solar corona and solar wind.

Sports-related sudden cardiac death in Switzerland classified by static and dynamic components of exercise.

PubMed

Gräni, Christoph; Chappex, Nina; Fracasso, Tony; Vital, Cristina; Kellerhals, Christoph; Schmied, Christian; Saguner, Ardan M; Trachsel, Lukas D; Eser, Prisca; Michaud, Katarzyna; Wilhelm, Matthias

2016-07-01

Sports-related sudden cardiac deaths (SrSCDs) occur most frequently in highly dynamic and/or static sports. We aimed to assess the incidence and characteristics of SrSCDs in Switzerland and to compare SrSCD occurrence according to sports categories with the sports participation behaviour in the general population. Between 1999 and 2010, forensic reports of SrSCDs in young individuals (10-39 years of age) were retrospectively reviewed and categorised based on peak static (increasing from I to III) and dynamic sports components (increasing from A to C). Data were compared to the sports participation behaviour of the Swiss population. Sixty-nine SrSCDs were identified. Forty-eight (69.6%) occurred during recreational sports (REC) and 21 (30.4%) during competitive sports (COMP). Incidences (per 100,000 athlete person-years) for COMP and REC were 0.90 and 0.52, respectively (p = 0.001). Most SrSCDs occurred in IC (23 cases, 33.3%), followed by IIC (13, 18.9%), IIIA and IIIC (11 each, 15.9%), IIIB (6, 8.7%), IIA (4, 5.8%) and IB sports categories (1, 1.5%). No SrSCDs were found in IA and IIB sports categories. Incidences between sports categories (IIIA 0.25, IB 0.25, IC 0.18, IIC 0.33 and IIIC 0.25) were not significantly different except to IIA (0.94, p < 0.001), due to the fact that few people were involved in this sports category. Coronary artery disease (CAD) was the most common underlying pathology of SrSCD. In this Swiss cohort, incidence of SrSCD was very low and similar in all sports categories classified by their static and dynamic components. However, the incidence was higher in COMP compared to REC, and CAD proved to be the most common underlying cause of SrSCD. © The European Society of Cardiology 2016.

Resistance Exercise Attenuates High-Fructose, High-Fat-Induced Postprandial Lipemia

PubMed Central

Wilburn, Jessie R; Bourquin, Jeffrey; Wysong, Andrea; Melby, Christopher L

2015-01-01

INTRODUCTION Meals rich in both fructose and fat are commonly consumed by many Americans, especially young men, which can produce a significant postprandial lipemic response. Increasing evidence suggests that aerobic exercise can attenuate the postprandial increase in plasma triacylglycerols (TAGs) in response to a high-fat or a high-fructose meal. However, it is unknown if resistance exercise can dampen the postprandial lipemic response to a meal rich in both fructose and fat. METHODS Eight apparently healthy men (Mean ± SEM; age = 27 ± 2 years) participated in a crossover study to examine the effects of acute resistance exercise on next-day postprandial lipemia resulting from a high-fructose, high-fat meal. Participants completed three separate two-day conditions in a random order: (1) EX-COMP: a full-body weightlifting workout with the provision of additional kilocalories to compensate for the estimated net energy cost of exercise on day 1, followed by the consumption of a high-fructose, high-fat liquid test meal the next morning (day 2) (~600 kcal) and the determination of the plasma glucose, lactate, insulin, and TAG responses during a six-hour postprandial period; (2) EX-DEF: same condition as EX-COMP but without exercise energy compensation on day 1; and (3) CON: no exercise control. RESULTS The six-hour postprandial plasma insulin and lactate responses did not differ between conditions. However, the postprandial plasma TAG concentrations were 16.5% and 24.4% lower for EX-COMP (551.0 ± 80.5 mg/dL × 360 minutes) and EX-DEF (499.4 ± 73.5 mg/dL × 360 minutes), respectively, compared to CON (660.2 ± 95.0 mg/dL × 360 minutes) (P < 0.05). CONCLUSIONS A single resistance exercise bout, performed ~15 hours prior to a high-fructose, high-fat meal, attenuated the postprandial TAG response, as compared to a no-exercise control condition, in healthy, resistance-trained men. PMID:26508874

Resistance Exercise Attenuates High-Fructose, High-Fat-Induced Postprandial Lipemia.

PubMed

Wilburn, Jessie R; Bourquin, Jeffrey; Wysong, Andrea; Melby, Christopher L

2015-01-01

Meals rich in both fructose and fat are commonly consumed by many Americans, especially young men, which can produce a significant postprandial lipemic response. Increasing evidence suggests that aerobic exercise can attenuate the postprandial increase in plasma triacylglycerols (TAGs) in response to a high-fat or a high-fructose meal. However, it is unknown if resistance exercise can dampen the postprandial lipemic response to a meal rich in both fructose and fat. Eight apparently healthy men (Mean ± SEM; age = 27 ± 2 years) participated in a crossover study to examine the effects of acute resistance exercise on next-day postprandial lipemia resulting from a high-fructose, high-fat meal. Participants completed three separate two-day conditions in a random order: (1) EX-COMP: a full-body weightlifting workout with the provision of additional kilocalories to compensate for the estimated net energy cost of exercise on day 1, followed by the consumption of a high-fructose, high-fat liquid test meal the next morning (day 2) (~600 kcal) and the determination of the plasma glucose, lactate, insulin, and TAG responses during a six-hour postprandial period; (2) EX-DEF: same condition as EX-COMP but without exercise energy compensation on day 1; and (3) CON: no exercise control. The six-hour postprandial plasma insulin and lactate responses did not differ between conditions. However, the postprandial plasma TAG concentrations were 16.5% and 24.4% lower for EX-COMP (551.0 ± 80.5 mg/dL × 360 minutes) and EX-DEF (499.4 ± 73.5 mg/dL × 360 minutes), respectively, compared to CON (660.2 ± 95.0 mg/dL × 360 minutes) (P < 0.05). A single resistance exercise bout, performed ~15 hours prior to a high-fructose, high-fat meal, attenuated the postprandial TAG response, as compared to a no-exercise control condition, in healthy, resistance-trained men.

Levels of biomarkers correlate with magnetic resonance imaging progression of knee cartilage degeneration: a study on canine.

PubMed

Qi, Chang; Changlin, Huang

2007-07-01

To examine the association between levers of cartilage oligomeric matrix protein (COMP), matrix metalloproteinases-1 (MMP-1), matrix metalloproteinases-3 (MMP-3), tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) in serum and synovial fluid, and MR imaging of cartilage degeneration in knee joint, and to understand the effects of movement training with different intensity on cartilage of knee joint. 20 adult canines were randomly divided into three groups (8 in the light training group; 8 in the intensive training group; 4 in the control group), and canines of the two training groups were trained daily at different intensity. The training lasted for 10 weeks in all. Magnetic resonance imaging (MRI) examinations were performed regularly (2, 4, 6, 8, 10 week) to investigate the changes of articular cartilage in the canine knee, while concentrations of COMP, MMP-1, MMP-3, TIMP-1 in serum and synovial fluid were measured by ELISA assays. We could find imaging changes of cartilage degeneration in both the training groups by MRI examination during training period, compared with the control group. However, there was no significant difference between these two training groups. Elevations of levels of COMP, MMP-1, MMP-3, TIMP-1, MMP-3/TIMP-1 were seen in serum and synovial fluid after training, and their levels had obvious association with knee MRI grades of cartilage lesion. Furthermore, there were statistically significant associations between biomarkers levels in serum and in synovial fluid. Long-time and high-intensity movement training induces cartilage degeneration in knee joint. Within the intensity extent applied in this study, knee cartilage degeneration caused by light training or intensive training has no difference in MR imaging, but has a comparatively obvious difference in biomarkers level. To detect articular cartilage degeneration in early stage and monitor pathological process, the associated application of several biomarkers has a very good practical value, and can be used as a helpful supplement to MRI.

Protection against tuberculosis by a single intranasal administration of DNA-hsp65 vaccine complexed with cationic liposomes

PubMed Central

Rosada, Rogério S; Torre, Lucimara Gaziola de la; Frantz, Fabiani G; Trombone, Ana PF; Zárate-Bladés, Carlos R; Fonseca, Denise M; Souza, Patrícia RM; Brandão, Izaíra T; Masson, Ana P; Soares, Édson G; Ramos, Simone G; Faccioli, Lúcia H; Silva, Célio L; Santana, Maria HA; Coelho-Castelo, Arlete AM

2008-01-01

Background The greatest challenges in vaccine development include optimization of DNA vaccines for use in humans, creation of effective single-dose vaccines, development of delivery systems that do not involve live viruses, and the identification of effective new adjuvants. Herein, we describe a novel, simple technique for efficiently vaccinating mice against tuberculosis (TB). Our technique consists of a single-dose, genetic vaccine formulation of DNA-hsp65 complexed with cationic liposomes and administered intranasally. Results We developed a novel and non-toxic formulation of cationic liposomes, in which the DNA-hsp65 vaccine was entrapped (ENTR-hsp65) or complexed (COMP-hsp65), and used to immunize mice by intramuscular or intranasal routes. Although both liposome formulations induced a typical Th1 pattern of immune response, the intramuscular route of delivery did not reduce the number of bacilli. However, a single intranasal immunization with COMP-hsp65, carrying as few as 25 μg of plasmid DNA, leads to a remarkable reduction of the amount of bacilli in lungs. These effects were accompanied by increasing levels of IFN-γ and lung parenchyma preservation, results similar to those found in mice vaccinated intramuscularly four times with naked DNA-hsp65 (total of 400 μg). Conclusion Our objective was to overcome the significant obstacles currently facing DNA vaccine development. Our results in the mouse TB model showed that a single intranasal dose of COMP-hsp65 elicited a cellular immune response that was as strong as that induced by four intramuscular doses of naked-DNA. This formulation allowed a 16-fold reduction in the amount of DNA administered. Moreover, we demonstrated that this vaccine is safe, biocompatible, stable, and easily manufactured at a low cost. We believe that this strategy can be applied to human vaccines to TB in a single dose or in prime-boost protocols, leading to a tremendous impact on the control of this infectious disease. PMID:18647414

Studies performed in the proper context suggest that antimicrobial use during swine and cattle production minimally impact antimicrobial resistance

USDA-ARS?s Scientific Manuscript database

In the United States (U.S.) it is estimated that food-animal production agriculture accounts for >70% of antimicrobial (AM) use leading to concerns that agricultural uses are the primary source of antimicrobial resistance (AMR). Many studies report AMR in food-animal production settings without comp...

DEVELOPING AND IMPLEMENTING A LEAD DUST MONITORING, OUTREACH AND EDUCATION PROGRAM IN YOUR COMMUNITY/SYRACUSE LEAD DUST PROJECT

EPA Science Inventory

EPA has developed a technology transfer document (case-study) for the EMPACT Syracuse Lead Dust Project. The Lead Dust Project is designed to measure the lead dust content in homes and public buildings within the City of Syracuse, NY. The project also contains an educational comp...

Investigation of Surface Breakdown on Semiconductor Devices Using Optical Probing Techniques.

DTIC Science & Technology

1990-01-01

18] L. Bovino , T. Burke, R. Youmans, M. Weiner, and J. Car, r, "Recent Advances in Optically C’ntrolled Bulk Semiconductor Switches," Digest of...Comp. Simul. 5 (3), 175 (1988). [321 M. Weiner, L. Bovino , R. Youmans, and T. Burke, "Modeling of the Optically Conrolled Semiconductor Switch," J

Generalizability of the Differential Coursework Methodology: Relationships between Self-Reported Coursework and Performance on the ACT-COMP Exam.

ERIC Educational Resources Information Center

Pike, Gary R.; Phillippi, Raymond H.

1989-01-01

Measures of student achievement must be linked to the characteristics of academic programs. The Differential Coursework Patterns Project at Iowa State University was used by the University of Tennessee at Knoxville as a method of linking outcome measures to program data. Results are discussed. (Author/MLW)

Cross-Talk in Comp Theory: A Reader. Second Edition, Revised and Updated.

ERIC Educational Resources Information Center

Villanueva, Victor, Ed.

This revised and updated resource contains a total of 43 essays that serve to initiate graduate students and more experienced teachers into the theories that inform composition studies. Under Section One--The Givens in Our Conversations: The Writing Process--are these essays: "Teach Writing as a Process Not Product" (Donald M. Murray);…

Evaluation and characterization in bananas (Musa ssp.) at the USDA-ARS Tropical Agriculture Research Station

USDA-ARS?s Scientific Manuscript database

Banana, Musa spp., is a key horticultural crop in tropical regions of the world where they provide sustenance and serve as cash crops. The plantain subgroup in particular, is an important staple in the Caribbean, Central America and some countries in South America. One of the integral research comp...

INSIGHTS FROM AHR AND ARNT GENE KNOCKOUT STUDIES REGARDING RESPONSES TO TCDD AND REGULATION OF NORMAL EMBRYONIC DEVELOPMENT

EPA Science Inventory

The aryl hydrocarbon receptor (AhR) and the AhR nuclear translocator (ARNT) are members of the Per-ARNT-Sim (PAS) family of proteins. The AhR binds members of the chemical family that includes dioxins, furans and coplanar polychlorinated biphenyls (PCBs). A ligand-AhR-ARNT comp...

Target and non-target toxicity of botanical insecticide derived from Couroupita guianensis L. flower against generalist herbivore, Spodoptera litura Fab. and an earthworm, Eisenia foetida Savigny

USDA-ARS?s Scientific Manuscript database

Novel chemistries in botanical insecticides may provide alternatives to, or development of synthetic insecticides suitable for controlling the Lepidopteran pests, like Spodoptera litura (F.). Many botanical chemistries are biodegradable, and have lower mammalian toxicity. Eight natural chemical comp...

10 CFR Appendix A to Part 600 - Generally Applicable Requirements

Code of Federal Regulations, 2014 CFR

2014-01-01

...)). Sec. 7(b), Indian Self-Determination and Education Assistance Act (25 U.S.C. 450e(b)). Cargo... Competitive Practices Act of 1974 (49 U.S.C. 1517). Executive Order 12138, “Creating a National Women's... National Program for Women's Business Enterprise,” (May 18, 1979) 3 CFR 1979 Comp., p. 393. Sec. 403(b...

77 FR 39653 - Proposed Establishment of Class E Airspace; Reidsville, GA, and Proposed Amendment of Class E...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-05

... at Reidsville, GA. Separation of existing Class E airspace surrounding Swinton Smith Field at... the surface at Swinton Smith Field at Reidsville Municipal Airport (formerly Reidsville Airport... CFR, 1959-1963 Comp., p. 389. Sec. 71.1 [Amended] 2. The incorporation by reference in 14 CFR 71.1 of...