42 CFR 4.3 - Purpose of the Library.

Code of Federal Regulations, 2012 CFR

2012-10-01

... medical and related sciences and aid the dissemination and exchange of scientific and other information important to the progress of medicine and the public health. The Library acquires and maintains library...

42 CFR 4.3 - Purpose of the Library.

Code of Federal Regulations, 2014 CFR

2014-10-01

... medical and related sciences and aid the dissemination and exchange of scientific and other information important to the progress of medicine and the public health. The Library acquires and maintains library...

42 CFR 4.3 - Purpose of the Library.

Code of Federal Regulations, 2011 CFR

2011-10-01

... medical and related sciences and aid the dissemination and exchange of scientific and other information important to the progress of medicine and the public health. The Library acquires and maintains library...

42 CFR 4.3 - Purpose of the Library.

Code of Federal Regulations, 2013 CFR

2013-10-01

... medical and related sciences and aid the dissemination and exchange of scientific and other information important to the progress of medicine and the public health. The Library acquires and maintains library...

A Preservation Program for the Colorado State University Libraries. The Final Report of the ARL/OMS Preservation Planning Program.

ERIC Educational Resources Information Center

Green, Stephen; And Others

This final report is a product of a Preservation Planning Program (PPP) self-study conducted by the Colorado State University Library (CSUL) working with the Association of Research Libraries' (ARL) Office of Management Studies (OMS). Designed to put self-help tools into the hands of library staff responsible for developing plans and procedures…

Libraries of Middlesex, Final Performance Report for Library Services and Construction Act (LSCA) Title VI, Library Literacy Program.

ERIC Educational Resources Information Center

Director, Elissa

This final performance report for the Libraries of Middlesex literacy project begins with a section that compares actual accomplishments to the following objectives for 1992-93: (1) recruit and enroll at least 150 new volunteers in Basic Reading of English as a Second Language (ESL) tutor training; (2) have at least 125 volunteers successfully…

E-Commerce for Library Promotion and Sustainability: How Library Technicians Can Market Themselves and Their Library's Services Online

ERIC Educational Resources Information Center

von Retzlaff, Lothar

2006-01-01

As players in the delivery of services and online information, libraries are in the best position to use staff expertise and the technology they have developed to foster community awareness of social, professional and commercial interactions on the internet. Historically, libraries have been progressive institutions, undertaking constant…

Statistical molecular design of balanced compound libraries for QSAR modeling.

PubMed

Linusson, A; Elofsson, M; Andersson, I E; Dahlgren, M K

2010-01-01

A fundamental step in preclinical drug development is the computation of quantitative structure-activity relationship (QSAR) models, i.e. models that link chemical features of compounds with activities towards a target macromolecule associated with the initiation or progression of a disease. QSAR models are computed by combining information on the physicochemical and structural features of a library of congeneric compounds, typically assembled from two or more building blocks, and biological data from one or more in vitro assays. Since the models provide information on features affecting the compounds' biological activity they can be used as guides for further optimization. However, in order for a QSAR model to be relevant to the targeted disease, and drug development in general, the compound library used must contain molecules with balanced variation of the features spanning the chemical space believed to be important for interaction with the biological target. In addition, the assays used must be robust and deliver high quality data that are directly related to the function of the biological target and the associated disease state. In this review, we discuss and exemplify the concept of statistical molecular design (SMD) in the selection of building blocks and final synthetic targets (i.e. compounds to synthesize) to generate information-rich, balanced libraries for biological testing and computation of QSAR models.

Information Handling in Selected Academic Libraries of the Caribbean.

ERIC Educational Resources Information Center

Rodriguez, Ketty

1988-01-01

Describes a survey that examined the extent of library technical processes automation within academic libraries at 10 Caribbean universities. Existing conditions, steps in progress, and plans for future automation are discussed. (8 references) (CLB)

Past into Future: Capturing Library Expertise in a Virtual Library.

ERIC Educational Resources Information Center

Daniels, Wayne; Scardellato, Kathy

1999-01-01

Reports on an initiative by the Toronto Public Library to create the "Virtual Reference Library" (VRL). Describes the first service to be offered, a Dewey application called "Science Net." Discusses the VRL and its precursor, objectives, basis for its funding, technical aspects, progress to date and future direction. (AEF)

Are We Ready for the Virtual Library? Technology Push, Market Pull and Organisational Response.

ERIC Educational Resources Information Center

Gilbert, J. D.

1993-01-01

Discusses virtual libraries, i.e., library services available to users via personal computers; considers the issues of technological development, user demands, and organizational response; and describes progress toward virtual libraries in the Netherlands, including networks, online systems, navigation tools, subject classification, coordination…

Long-Range Strategic Planning for Libraries & Information Resources in the Research University. The Final Report on a Research Program on the Future of the Academic Research Library.

ERIC Educational Resources Information Center

California Univ., Los Angeles. Graduate School of Library and Information Science.

This final report on a project at the University of California at Los Angeles (UCLA) on strategic planning for libraries and information resources in the research university begins with an introductory section on levels of consideration in planning; issues of current concern (effects of technology, economics of libraries, changes in the academic…

Lewistown City Library, Final Performance Report for Library Services and Construction Act (LSCA) Title VI, Library Literacy Program.

ERIC Educational Resources Information Center

Stead, Sharon

This final performance report for the Lewistown City Library L.E.A.R.N. (Let Every Adult Read Now!) literacy project begins with a section that provides quantitative data. The next section compares actual accomplishments to the following project goals for 1992-93: to serve a minimum of 25 adult literacy students within an 18-month period and to…

Academic Libraries in Ohio. Progress through Collaboration, Storage, and Technology. Report of the Library Study Committee.

ERIC Educational Resources Information Center

Ohio Board of Regents, Columbus.

Based on a study of the need for, and alternatives to, significant expansion of space for state college and university libraries, this report discusses the resultant recommendations, which address both the long term and the immediate space needs of the state's academic libraries. Following a description of the role of academic libraries and a…

A Status Report on Levels of Library and Information Services of Utah Libraries.

ERIC Educational Resources Information Center

Wood, R. Kent

While much progress has been made since the creation of the Utah State Library Commission more than two decades ago, much more remains to be done to improve library and information services in the state. There is a critical need in school media centers for professionally trained library personnel where non-professionals may now be substituting,…

Future Prospects of Library Acquisitions

ERIC Educational Resources Information Center

Downs, Robert B.

1970-01-01

Technical progress in transmission and microreproduction have created a need for drastic revisions in the traditional research library's goal of autonomy in serving the needs of its clientele. Trends toward viewing library collections as segments of a national resource are summarized. (JS)

Preservation Planning Project Study Team. Final Report.

ERIC Educational Resources Information Center

Pittsburgh Univ., PA. Libraries.

This final report is a product of a comprehensive 14-month Preservation Planning Program (PPP) self-study conducted by the University of Pittsburgh Libraries, working with the Association of Research Libraries' (ARL) Office of Management Studies. The PPP is designed to put self-help tools into the hands of library staff responsible for developing…

New Essentials for the Library as Learning Commons

ERIC Educational Resources Information Center

Gamble, Jay

2011-01-01

Library teachers can no longer do business as usual--their students' deep learning is at risk! Expanding current collection of books, CDs, and DVDs is progress, but library teachers cannot allow their facilities to become warehouses for information resources. Their library learning commons should be a place buzzing with the hustle and bustle of…

Oregonians and Their Library and Information Services. A Progress Report.

ERIC Educational Resources Information Center

Thorne, Maggie, Comp.

Compiled in response to questions from Oregon citizens about library and information services in their state, this report contains: (1) a general description of the Governor's Conference on Library and Information Services held in June 1978; (2) a delegate's viewpoint on the White House Conference on Library and Information Services (WHCLIS); (3)…

Smart Libraries: Integrating Communications Channels and Information Sources.

ERIC Educational Resources Information Center

Webb, T. D.; Jensen, E. A.

Noting that the changing nature of information delivery has established immediacy as the new basis for modern library service, this paper describes the new facilities design and floor plan for the library of Kapiolani Community College of the University of Hawaii. The new library was carefully designed so that students can move progressively from…

Preservation Planning Program. Study Report. Iowa State University Library. Final Report.

ERIC Educational Resources Information Center

Galejs, John; And Others

This final report is a product of a Preservation Planning Program (PPP) self-study conducted by the Iowa State University, working with the Association of Research Libraries' (ARL) Office of Management Studies. The PPP is designed to put self-help tools into the hands of library staff responsible for developing plans and procedures for preserving…

Progress and Problems of Pennsylvania Libraries; a Re-Survey.

ERIC Educational Resources Information Center

Martin, Lowell A.

Following an earlier study of public libraries in Pennsylvania, issued in 1958, this "re-survey" has two purposes: (1) to determine the extent to which the 1958 Pennsylvania library program has been achieved and (2) to propose a revised or new Pennsylvania library program. The basis for the study is 1965-66 data which was obtained from…

The ELISE II Project: A Digital Image Library for Europe.

ERIC Educational Resources Information Center

Strunz, Bob; Waters, Mairead

This paper describes the progress made under the ELISE II electronic image library project from a technical standpoint. The ELISE II project is a European-wide initiative that aims to provide a comprehensive electronic image library service for Europe. It is funded under the European Commission, DG XIII-E, Telematics for Libraries Initiative. The…

A History of the Utilization of Technology in Academic Libraries.

ERIC Educational Resources Information Center

Boden, Dana W. R.

This paper examines the history of academic libraries with special emphasis on the beginnings, growth, and progress in the uses of technology in those libraries. The earliest libraries were maintained for the preservation of knowledge and information. Access to the items in these collections was limited. With the growth of higher education in the…

Networking Activities at the Library of Congress.

ERIC Educational Resources Information Center

Maruyama, Lenore S.; Avram, Henriette D.

1979-01-01

Examines the background studies and high-priority projects which will lay the groundwork for the library bibliographic component of a National Library and Information Service Network and reviews the progress and problems of the national network as evidenced by current cooperative projects. (CWM)

Molecular insights of protein contour recognition with ligand pharmacophoric sites through combinatorial library design and MD simulation in validating HTLV-1 PR inhibitors.

PubMed

Selvaraj, Chandrabose; Omer, Ankur; Singh, Poonam; Singh, Sanjeev Kumar

2015-01-01

Retroviruses HIV-1 and HTLV-1 are chiefly considered to be the most dangerous pathogens in Homo sapiens. These two viruses have structurally unique protease (PR) enzymes, which are having common function of its replication mechanism. Though HIV PR drugs failed to inhibit HTLV-1 infections, they emphatically emphasise the need for designing new lead compounds against HTLV-1 PR. Therefore, we tried to understand the binding level interactions through the charge environment present in both ligand and protein active sites. The domino effect illustrates that libraries of purvalanol-A are attuned to fill allosteric binding site of HTLV-1 PR through molecular recognition and shows proper binding of ligand pharmacophoric features in receptor contours. Our screening evaluates seven compounds from purvalanol-A libraries, and these compounds' pharmacophore searches for an appropriate place in the binding site and it places well according to respective receptor contour surfaces. Thus our result provides a platform for the progress of more effective compounds, which are better in free energy calculation, molecular docking, ADME and molecular dynamics studies. Finally, this research provided novel chemical scaffolds for HTLV-1 drug discovery.

Identification of Information Needs of the American Indian Community That Can Be Met by Library Services. Final Report, June 1975.

ERIC Educational Resources Information Center

Townley, Charles T.

As the final report on the National Indian Education Association's (NIEA) Library Project, this document presents the following: (1) an introduction (describes the general condition of American Indian library service, the involvement of NIEA, and the project's objectives and time line); (2) the methodology of Phase I: identification of…

77 FR 40345 - Notice of the Availability of Record of Decision for the Final Supplemental Environmental Impact...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-09

... and Final SEIS are also available for viewing at the: 1. San Francisco Main Library, 100 Larkin Street, San Francisco, CA 94102; 2. San Francisco State University Library, 1360 Holloway Avenue, San Francisco, CA 94132; 3. Hastings Law Library, UC Hastings College of the Law, 200 McAllister Street, 4th...

Software Library: A Reusable Software Issue.

DTIC Science & Technology

1984-06-01

On reverse aide it neceeary aid Identify by block number) Software Library; Program Library; Reusability; Generator 20 ABSTRACT (Cmlnue on revere... Software Library. A particular example of the Software Library, the Program Library, is described as a prototype of a reusable library. A hierarchical... programming libraries are described. Finally, non code products in the Software Library are discussed. Accesson Fo NTIS R~jS DrrC TA Availability Codes 0

Identification of Information Needs of the American Indian Community That Can Be Met by Library Services. Phase IV. Progress Report.

ERIC Educational Resources Information Center

Townley, Charles T.

Under a grant from the Bureau of Libraries and Learning Resources of the United States Office of Education, the National Indian Education Association (NIEA) implemented a Library Project to identify library and information needs of Indian people and to establish, operate, and evaluate three demonstration sites. During this reporting period,…

A Historical Introduction to Library Education: Problems and Progress to 1951.

ERIC Educational Resources Information Center

White, Carl M.

The growth of libraries and of technical education in the middle of the 19th century led to the organization of Melvil Dewey's School of Library Economy in 1887. The School offered a technical course to replace the apprenticeships then in favor. Its curriculum persisted as the model for library education through 1920. A break with the early form…

Improving Usage Statistics Processing for a Library Consortium: The Virtual Library of Virginia's Experience

ERIC Educational Resources Information Center

Matthews, Tansy E.

2009-01-01

This article describes the development of the Virtual Library of Virginia (VIVA). The VIVA statistics-processing system remains a work in progress. Member libraries will benefit from the ability to obtain the actual data from the VIVA site, rather than just the summaries, so a project to make these data available is currently being planned. The…

Looking for Collection 2.0

ERIC Educational Resources Information Center

Buczynski, James A.

2008-01-01

Libraries are integrating Web 2.0 services into work practices, positioning themselves in online social environments, and deploying enhanced search and discovery tools. Collections conversely are not progressing to the same degree. Like many public services today, library budgets are stained. User-pay options are appearing in library systems,…

LIS Journals in the Knowledge Age.

ERIC Educational Resources Information Center

Breen, Eileen

This paper examines EMERALD LIS and how it facilitates the use of information contained in LIS (library and information science) journals for improvements and progress. EMERALD LIS is a full-text database of journals in information management, library technology, library and information service management, and collection management/development.…

Access and Ownership in the Academic Environment: One Library's Progress Report.

ERIC Educational Resources Information Center

Brin, Beth; Cochran, Elissa

1994-01-01

Describes the methodology used at the University of Arizona Library to address the issue of access versus ownership of library materials. Topics discussed include participatory management; data collection, including focus groups, interlibrary loan statistics, and graduate research citation analysis; and resulting recommendations, including…

A Bibliographic Bank for Resource Sharing in Library Systems: A Feasibility Study. Final Report.

ERIC Educational Resources Information Center

Schwartz, Eugene S.; Saxe, Henry I.

This study of resource sharing among public libraries was made possible by six library systems in northern Illinois. With the organization of the library systems and development of interlibrary loan services and other cooperative activities, the problem of extending resource sharing among member libraries and between library systems arose. Several…

New Technology and the Public Library. Final Report and Executive Summary.

ERIC Educational Resources Information Center

Griffiths, Jose-Marie; King, Donald W.

This report presents current and potential library applications of new technologies, issues surrounding their introduction into public libraries, and activities suggested for use during the introduction procedure. A brief appraisal of the public library's role in the information transfer process precedes a review of library automation in…

A Study of the Effects of Creative Dramatics on the Progress in Use of the Library, Reading Interests, Reading Achievement, Self-Concept, Creativity, and Empathy of Fourth and Fifth Grade Children.

ERIC Educational Resources Information Center

Ziegler, Elsie Mae

To appraise the value of a creative dramatics program in a public library setting was the purpose of this study. Nine public library branches comprised the setting for the experiment. At each branch there were three units: (1) creative dramatics, (2) storytelling, and (3) library usage. Storytelling and library usage were the control group. Pre…

75 FR 22120 - Notice of Roundtables and Request for Comments on Enhancement in the Quality of Patents and on...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-27

... quality and the metrics the USPTO should use to measure progress. The roundtables are open to the public... will be held at the Los Angeles Public Library--Central Library, which is located at 630 W. 5th Street... USPTO is conducting two roundtables, one at the Los Angeles Public Library--Central Library facility...

Design for Progress. A Report of the Workshop in School Library Quarters and Equipment, July 9 to 20, 1962.

ERIC Educational Resources Information Center

Strohecker, Edwin C., Ed.

Significant ideas brought out in the workshop include--(1) that the library is a necessary part of the whole relational structure in education, and (2) that changes in educational programs and methods call for new library planning standards; a library should be able to provide science facilities, audiovisual materials, and a variety of group-work…

Library services for persons with disabilities: twentieth anniversary update.

PubMed

Willis, Christine A

2012-01-01

In recognition of the twentieth anniversary of the Americans with Disabilities Act (ADA), this survey updates the progress and reflects on the status of academic health sciences library services for people with disabilities since the Nelson study in 1996. The results of this survey extend beyond academic libraries to hospital libraries and include areas where all libraries can improve disability access. Based on a 24% response rate, libraries have addressed accessibility of technology in cost-effective and relatively easy ways. Libraries are reactively rather than proactively making changes to services for persons with disabilities. Copyright © Taylor & Francis Group, LLC

LC21-Hopes and Cautions for the Library of Congress; The NSF National Science, Mathematics, Engineering, and Technology Education Digital Library (NSDL) Program: A Progress Report; A Grammar of Dublin Core; Measuring the Impact of an Electronic Journal Collection on Library Costs: A Framework and Preliminary Observations; Emulation As a Digital Preservation Strategy.

ERIC Educational Resources Information Center

O'Donnell, James J.; Zia, Lee L.; Baker, Thomas; Montgomery, Carol Hansen; Granger, Stewart

2000-01-01

Includes five articles: (1) discusses Library of Congress efforts to include digital materials; (2) describes the National Science Foundation (NSF) digital library program to improve science, math, engineering, and technology education; (3) explains Dublin Core grammar; (4) measures the impact of electronic journals on library costs; and (5)…

Studying the Cost and Value of Library Services: Final Report. Technical Report APLAB/94-3/1,2,3,4.

ERIC Educational Resources Information Center

Kantor, Paul B.; And Others

This is the final technical report (in three parts) of a 15-month long project to study the costs and value of library functions at five major research libraries. Twenty-one services or service aspects were studied, and numerous measures of the importance or benefit of the service to the users were made. These measures were studied together to lay…

MR 201424 Final Report Addendum

DTIC Science & Technology

2016-09-01

FINAL REPORT ADDENDUM Munitions Classification Library ESTCP Project MR-201424 SEPTEMBER 2016 Mr. Craig Murray Dr. Nagi Khadr Parsons Dr...solver and multi-solver library databases, and only the TEMTADS 2X2 and the MetalMapper advanced TEM systems are supported by UX-Analyze, data on...other steps (section 3.4) before getting into the data collection activities (sections 3.5-3.7). All inversions of library quality data collected over

Massachusetts Libraries: An Alliance for the Future. [Final Report and Executive Summary] for the Massachusetts Board of Library Commissioners.

ERIC Educational Resources Information Center

Griffiths, Jose-Marie; King, Donald W.

A comprehensive study of the current state of library services and library cooperative activities in Massachusetts found that the state's 2,796 public, academic, school, institutional and special libraries make a significant contribution to lifelong learning, to the economy, and to the quality of life. The libraries have a combined collection of…

Wayne Township Public Library, Final Performance Report for Library Services and Construction Act (LSCA) Title VI, Library Literacy Program.

ERIC Educational Resources Information Center

Smyth, Carol B.; Grannell, Dorothy S.; Moore, Miriam

The Literacy Resource Center project, a program of the Wayne Township Public Library also known as the Morrisson-Reeves Library (Richmond, Indiana), involved recruitment, retention, coalition building, public awareness, training, basic literacy, collection development, tutoring, computer-assisted, other technology, employment oriented,…

Public Library Statistics, 1950. Bulletin, 1953, No. 9

ERIC Educational Resources Information Center

Dunbar, Ralph M.

1954-01-01

The Office of Education has long been interested in the development of public libraries as agencies to further the educational progress of the nation. Beginning with 1870, it has issued at intervals statistical compilations on the status of the various types of libraries. Marking a change in that program, the comprehensive collection covering…

Adults with Special Needs. A Resource and Planning Guide for Wisconsin's Public Libraries.

ERIC Educational Resources Information Center

Huntington, Barbara; Swanson, Coral

This publication is intended to assist Wisconsin's public libraries and public library systems in providing service to adults with special needs (ASN). Twelve chapters cover the following topics: (1) planning for success, including planning services and measuring progress; (2) a Wisconsin vision for the future, including creating the vision and…

Libraries Adding Value with Technology Training

ERIC Educational Resources Information Center

Vengersammy, Ormilla

2011-01-01

Traditional libraries are being redefined. They are not only places to access books in print, but are also rich resources for digital assets. As a result, technology training programs need to progress beyond basic "mouse and keyboard" in order to meet the ever-changing needs and demands of the public. As library collections transition to…

Academic Library Service to Disabled Students: Today and Tomorrow.

ERIC Educational Resources Information Center

Stone, Elizabeth W.

The presentation focuses on the status of disabled persons in the world, notes progress made in improved living conditions for the disabled, and considers implications for libraries serving disabled clients. Services currently offered in academic libraries are described, as are goals related to four aims specified by the United Nations during the…

Libraries' Place in Virtual Social Networks

ERIC Educational Resources Information Center

Mathews, Brian S.

2007-01-01

Do libraries belong in the virtual world of social networking? With more than 100 million users, this environment is impossible to ignore. A rising philosophy for libraries, particularly in blog-land, involves the concept of being where the users are. Simply using new media to deliver an old message is not progress. Instead, librarians should…

Market-Based Adult Lifelong Learning Performance Measures for Public Libraries Serving Lower Income and Majority-Minority Markets. Final Performance Report. September 1, 1996-August 31, 1999.

ERIC Educational Resources Information Center

Koontz, Christine; Jue, Dean K.; Lance, Keith Curry

This document is the final performance report for a Field Initiated Studies (FIS) project that addressed the need for a better assessment of public library services for adult lifelong learning in majority-minority and lower income library market areas. After stating the major educational problem addressed by the FIS project, the report lists the…

Transportation library connectivity and development pooled fund study, final report.

DOT National Transportation Integrated Search

2015-12-01

This report is a record of the major activities and accomplishments of the Transportation Library : Connectivity and Development pooled fund study, TPF-5(237), from its approval by FHWA in : 2010 through its fifth and final annual meeting in August 2...

Feasibility Study for an Automated Library System. Final Report.

ERIC Educational Resources Information Center

Beaumont and Associates, Inc.

This study was initiated by the Newfoundland Public Library Services (NPLS) to assess the feasibility of automation for the library services and to determine the viability of an integrated automated library system for the NPLS. The study addresses the needs of NPLS in terms of library automation; benefits to be achieved through the introduction of…

Carver County Library System, Final Performance Report for Library Services and Construction Act (LSCA) Title VI, Library Literacy Program.

ERIC Educational Resources Information Center

Colhapp, Barbara; Miller, Lana

The Carver County Library System (Chaska, Minnesota) conducted a project to demonstrate adult educational teamwork between libraries and literacy agents in the Carver-Scott two county area. The project, "National Issues Forums (NIF) for the New Reader," extended educational opportunities that encouraged new adult readers and the public…

Final progress report, Construction of a genome-wide highly characterized clone resource for genome sequencing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nierman, William C.

At TIGR, the human Bacterial Artificial Chromosome (BAC) end sequencing and trimming were with an overall sequencing success rate of 65%. CalTech human BAC libraries A, B, C and D as well as Roswell Park Cancer Institute's library RPCI-11 were used. To date, we have generated >300,000 end sequences from >186,000 human BAC clones with an average read length {approx}460 bp for a total of 141 Mb covering {approx}4.7% of the genome. Over sixty percent of the clones have BAC end sequences (BESs) from both ends representing over five-fold coverage of the genome by the paired-end clones. The average phredmore » Q20 length is {approx}400 bp. This high accuracy makes our BESs match the human finished sequences with an average identity of 99% and a match length of 450 bp, and a frequency of one match per 12.8 kb contig sequence. Our sample tracking has ensured a clone tracking accuracy of >90%, which gives researchers a high confidence in (1) retrieving the right clone from the BA C libraries based on the sequence matches; and (2) building a minimum tiling path of sequence-ready clones across the genome and genome assembly scaffolds.« less

Focus Groups and Usability Testing in Redesigning an Academic Library's Web Site

ERIC Educational Resources Information Center

Oldham, Bonnie W.

2008-01-01

As the World Wide Web has advanced since its inception, librarians have endeavored to keep pace with this progress in the design of their library Web pages. User recommendations collected from focus groups and usability testing have indicated that the University of Scranton's Weinberg Memorial Library's Web site was not working as intended, and…

Reviving a Community's Adult Education Past: A Case Study of the Library's Role in Learning

ERIC Educational Resources Information Center

Irving, Catherine J.

2010-01-01

Amidst calls for libraries to regain their socially progressive roots and connections to community, this study analyzes two interwoven cases of nonformal, community education in northeastern Nova Scotia, initiated by libraries that aimed to revive those links. Through a reading circle and a people's school, librarians used historical materials on…

Academic Library Finance, 1970-1985: A Review of the Literature.

ERIC Educational Resources Information Center

Evans, John E.

Developed as a preliminary, literature-based study for a larger work in progress, this report summarizes the financial condition of academic libraries during the critical period from 1970 through the mid-1980's. The paper examines and addresses the issues which arose as libraries emerged from the 1960's, a time of unprecedented growth in library…

Audio from Orbit: The Future of Libraries for Individuals Who Are Blind or Vision Impaired

ERIC Educational Resources Information Center

Steer, Michael; Cheetham, Leonie

2005-01-01

Free library service is a component of the foundations of democracy, citizenship, economic and social development, scholarship and education, in progressive societies. The evolution of libraries for people who are blind or vision impaired is briefly discussed and an innovative project, a talking book and daily newspaper delivery system that…

Meriden Public Library, Final Performance Report for Library Services and Construction Act (LSCA) Title VI, Library Literacy Program.

ERIC Educational Resources Information Center

MacCabe, Bruce

The Literacy Learning Center Project, a project of the Meriden Public Library (Connecticut), targeted the educationally underserved and functionally illiterate, and involved recruitment, retention, space renovation, coalition building, public awareness, training, basic literacy, collection development, tutoring, computer assisted services, and…

On the Economics of Library Operation. Final Report Submitted to National Advisory Commission on Libraries.

ERIC Educational Resources Information Center

National Advisory Commission on Libraries, Washington, DC.

Both an analysis of the sources of cost trends in libraries and the relationship of the prospective role of automation in library operations to the causes of cost trends and the predicted shortage of trained librarians are examined in the study of the economic structure of the library. Issues investigated are those particularly relating to current…

SLEEC: Semantics-Rich Libraries for Effective Exascale Computation. Final Technical Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Milind, Kulkarni

SLEEC (Semantics-rich Libraries for Effective Exascale Computation) was a project funded by the Department of Energy X-Stack Program, award number DE-SC0008629. The initial project period was September 2012–August 2015. The project was renewed for an additional year, expiring August 2016. Finally, the project received a no-cost extension, leading to a final expiry date of August 2017. Modern applications, especially those intended to run at exascale, are not written from scratch. Instead, they are built by stitching together various carefully-written, hand-tuned libraries. Correctly composing these libraries is difficult, but traditional compilers are unable to effectively analyze and transform across abstraction layers.more » Domain specific compilers integrate semantic knowledge into compilers, allowing them to transform applications that use particular domain-specific languages, or domain libraries. But they do not help when new domains are developed, or applications span multiple domains. SLEEC aims to fix these problems. To do so, we are building generic compiler and runtime infrastructures that are semantics-aware but not domain-specific. By performing optimizations related to the semantics of a domain library, the same infrastructure can be made generic and apply across multiple domains.« less

Trailblazing in East Texas: A Progress Report on the Forest Trail Library Consortium's Networking Project.

ERIC Educational Resources Information Center

Claer, Joycelyn H.

This report describes the development of the Forest Trail Library Consortium (FTLC), a network of academic, public, and school libraries in Texas. The growth of FTLC from 4 charter members to its current 16 members is traced, including details about goals and funding. The role of special interest groups (SIGs) is examined, and the goals and…

The Context for Planning: A Report to the Jackson-George Regional Library System.

ERIC Educational Resources Information Center

McCook, Kathleen de la Pena; And Others

This report describes a study of the Jackson-George Regional Library (JGRL) System, which serves a 2-county area in Mississippi with a population of 131,918. The purpose of the study, which built on the planning and administration goals identified in "Planning for Progress: The Long Range Plan of the Jackson George Regional Library," was to…

Progress Report-Cataloging in Publication. July 1973 to June 1974. Report No. 5.

ERIC Educational Resources Information Center

Library of Congress, Washington, DC. Processing Dept.

The Library of Congress Cataloging in Publication (CIP) program is designed to provide professional cataloging data to publishers for printing in their books. From July 1973 to July 1974 the program has grown to include over 640 publishers. CIP is also being carried out by the National Library of Medicine and several major libraries in other…

Automation Is the Answer, but What Is the Question? Progress and Prospects for Central and Eastern European Libraries.

ERIC Educational Resources Information Center

Borgman, Christine L.

1996-01-01

Reports on a survey of 70 research libraries in Croatia, Czech Republic, Hungary, Poland, Slovakia, and Slovenia. Results show that libraries are rapidly acquiring automated processing systems, CD-ROM databases, and connections to computer networks. Discusses specific data on system implementation and network services by country and by type of…

Project BALLOTS: Bibliographic Automation of Large Library Operations Using a Time-Sharing System. Progress Report (3/27/69 - 6/26/69).

ERIC Educational Resources Information Center

Veaner, Allen B.

Project BALLOTS is a large-scale library automation development project of the Stanford University Libraries which has demonstrated the feasibility of conducting on-line interactive searches of complex bibliographic files, with a large number of users working simultaneously in the same or different files. This report documents the continuing…

CALIL.JP, a new web service that provides one-stop searching of Japan-wide libraries' collections

NASA Astrophysics Data System (ADS)

Yoshimoto, Ryuuji

Calil.JP is a new free online service that enables federated searching, marshalling and integration of Web-OPAC data on the collections of libraries from around Japan. It offers the search results through user-friendly interface. Developed with a concept of accelerating discovery of fun-to-read books and motivating users to head for libraries, Calil was initially designed mainly for public library users. It now extends to cover university libraries and special libraries. This article presents the Calil's basic capabilities, concept, progress made thus far, and plan for further development as viewed from an engineering development manager.

Hopkinsville-Christian County Library, Final Performance Report for Library Services and Construction Act (LSCA) Title VI, Library Literacy Program.

ERIC Educational Resources Information Center

Nevels, Vada Germaine

The Hopkinsville-Christian County Library (Kentucky) conducted a project that involved recruitment, public awareness, basic literacy, collection development, tutoring, computer-assisted, other technology, and intergenerational/family programs. The project served a community of 50,000-100,000 people, and targeted the learning disabled,…

Mesa County Public Library District, Final Performance Report for Library Services and Construction Act (LSCA) Title VI, Library Literacy Program.

ERIC Educational Resources Information Center

LaDuke, Caryl

The Adult Reading Program, a project of the Mesa County Public Library District (Grand Junction, Colorado), involved recruitment, retention, coalition building, public awareness, training, rural oriented, basic literacy, collection development, tutoring, employment oriented, intergenerational/family, and English as a Second Language (ESL)…

Library Power in Philadelphia: Final Report from Seven Case Studies.

ERIC Educational Resources Information Center

Useem, Elizabeth; Coe, Cati

Library Power seeks to activate an underutilized resource--a school's library program--in ways that promote schoolwide changes in the curriculum and instruction. This three-year initiative of the DeWitt Wallace-Readers' Digest Fund, located in 19 sites across the country, connects elementary and middle school libraries more directly to classroom…

Columbia County Public Library, Final Performance Report for Library Services and Construction Act (LSCA) Title VI, Library Literacy Program.

ERIC Educational Resources Information Center

Cole, Lucy; Fraser, Ruth

The Columbia County Public Library (Lake City, Florida) conducted a project that involved recruitment, retention, public awareness, training, basic literacy, collection development, tutoring, computer- assisted, other technology, intergenerational/family, and English as a Second Language (ESL) programs. The project served a community of…

The Public Library Effectiveness Study: Final Report.

ERIC Educational Resources Information Center

Childers, Thomas; Van House, Nancy A.

This study investigated the construct of effectiveness as it applies to public libraries and developed a methodology that can be transferred to other types of libraries and organizations. The research team began by compiling a list of indicators that are commonly used to gauge library effectiveness within the areas of: (1) services access; (2)…

Wyoming Academic Libraries Resource Project: Developing a Statewide Ariel Document Delivery Network. Final Report.

ERIC Educational Resources Information Center

Lange, Karen

The Wyoming Academic Libraries Resource Project was initiated to improve cooperation and resource sharing by developing an interconnected information access and delivery system among Wyoming's academic libraries and the State Library. The goal was to formalize communication, cooperation, and resource sharing by developing an Ariel document…

Studies in Public Library Government, Organization, and Support. Final Report.

ERIC Educational Resources Information Center

Garrison, Guy

This report consists of six individual reports that were done by staff members at the Library Research Center as part of the overall project. In Part I, "Financing Public Library Expansion: Case Studies of Three Defeated Bond Issue Referendums," Ruth G. Lindahl and William S. Berner analyze defeated library bond issue referendums in…

78 FR 34920 - Technical Amendments To Reflect the Authorizing Legislation of the Institute of Museum and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-11

... NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES Institute of Museum and Library Services 45 CFR... Museum and Library Services AGENCY: Institute of Museum and Library Services (IMLS), NFAH. ACTION: Technical amendment; final rule. SUMMARY: The Institute of Museum and Library amends its grants regulations...

National Library Service of the Library of Congress: New Electronic Information Projects. Part Four of a Four-Part Series.

ERIC Educational Resources Information Center

McNulty, Tom, Ed.

1995-01-01

This final installment of a four-part series on the National Library Service (NLS) examines recently implemented and future projects, with a focus on alternative formats for patrons with disabilities. Discusses LOCIS, the Library of Congress online public access catalog; MARVEL, the Library of Congress gopher; the NLS Web site; and computer disk…

School Partners in ILLINET. Automation Options for School Library Resource Sharing in Illinois. Final Report [and] Partners in ILLINET. Special Report.

ERIC Educational Resources Information Center

Howrey, Mary M.

This study was funded by the Library Services and Construction Act (LSCA) to enable the Illinois School Library Media Association (ISLMA) to plan the automation of the state's school libraries. The research was intended to identify current national programs of interest to ISLMA, identify current automation programs within Illinois library systems,…

Systems Development at the Grom Hayes Library.

ERIC Educational Resources Information Center

Yother, Larry W.

1987-01-01

Details the "painful" history, development, and progress of a "home-grown" library automation system at the Hartford State Technical College; describes several of the most common activities generated from menus; and looks at future prospects of the system. (Author/CLB)

A Functional Plan for an Illinois Library Telecommunications Network. The Final Report.

ERIC Educational Resources Information Center

Calabrese, Alice; And Others

This final report describes the plan developed by the Northern Illinois Learning Resources Cooperative, a consortium of 44 community colleges and other academic institutions, which was awarded a Library Services and Construction Act (LSCA) Title III planning grant to research the requirements for a statewide electronic network that would provide…

MnDOT Library strategic plan : final report.

DOT National Transportation Integrated Search

2017-06-01

MnDOTs Senior Leadership asked MnDOT Library to develop a Strategic Plan that identifies and reviews the challenges facing the Library over the next five years to better address the evolving needs of the department and users. The strategic plan is...

Planning for the integration of the digital library, clinical decision support, and evidence at the point of care.

PubMed

Schwartz, Linda Matula; Iobst, Barbara

2008-01-01

Integrating knowledge-based resources at the point of care is an important opportunity for hospital library involvement. In the progression of an IAIMS planning grant, the digital library is recognized as pivotal to the success of information domain integration throughout the institution. The planning process, data collection, and evolution of the planning project are discussed.

The Development of a Consumer Input Program for the National Library Service for the Blind and Physically Handicapped (NLS/BPH) and Network Libraries. Final Report.

ERIC Educational Resources Information Center

Cavenaugh, David

This document presents a review of the current consumer relations activites of the National Library Service (NLS) for the Blind and Physically Handicapped of the Library of Congress, and an overall plan to improve NLS receipt of user suggestions, comments, opinions, or complaints through libraries which form the nationwide NLS distribution system.…

Libraries and National Development (Final Report of the Third Afro-Nordic Library Conference, Finland, September 3-7 1979).

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Paris (France).

Contained in this collection of presentations from the third Afro-Nordic Library Conference are a foreword describing the objectives of the meeting and 14 papers: "From Oral Tradition to Literary Writing: The Awakening of National Awareness," by Heikki Kirkinen; "African Library Systems," by L. E. Samarasinghe; "Planning…

Marin County Free Library, Final Performance Report for Library Services and Construction Act (LSCA) Title VI, Library Literacy Program.

ERIC Educational Resources Information Center

Mooney, Sharon Lopez

The West Marin Literacy Project, a project of the Marin County Free Library (San Rafael, California), involved recruitment, retention, coalition building, public awareness, training, rural oriented, tutoring, computer- assisted, intergenerational/family, and English as a Second Language (ESL) programs. The project served a community of under…

Bibliographic Automation of Large Library Operations Using a Time-Sharing System: Phase I. Final Report.

ERIC Educational Resources Information Center

Epstein, A. H.; And Others

The first phase of an ongoing library automation project at Stanford University is described. Project BALLOTS (Bibliographic Automation of Large Library Operations Using a Time-Sharing System) seeks to automate the acquisition and cataloging functions of a large library using an on-line time-sharing computer. The main objectives are to control…

A Different Approach to the Evaluation of Research Libraries. Research Brief No. 6.

ERIC Educational Resources Information Center

Council on Library and Information Resources, Washington, DC.

In 1996, the Council on Library and Information Resources (CLIR) supported a project at Rutgers University that applied new economic theories to measuring how well research libraries fulfill their service roles. This summary draws on the original proposal and the final report from the project's directors. The evaluation of library performance is…

Martinsburg-Berkeley County Public Library, Final Performance Report for Library Services and Construction Act (LSCA) Title VI, Library Literacy Program.

ERIC Educational Resources Information Center

Hess, Therese M.

The Martinsburg-Berkeley County Public Library (West Virginia) conducted a project that involved recruitment, retention, coalition building, public awareness, training, basic literacy, collection development, tutoring, computer assisted, other technology, and English as a Second Language (ESL) programs. The project served a three-county community…

College Library Technology and Cooperation Grants Program, Higher Education Act, Title II-D. Final Performance Report.

ERIC Educational Resources Information Center

Hanifan, Thomas; Hoogheem, Cynthia L.

The Eastern Iowa Community College District (EICCD) libraries received a federal College Library Technology and Cooperation grant to provide and link public access catalogs at each college of the district--Clinton Community College, Muscatine Community College, and Scott Community College. That network is named Quad-LINC (Quad Cities Libraries in…

Criteria of Effectiveness for Network Delivery of Citizens Information through Libraries. Final Report.

ERIC Educational Resources Information Center

Chen, Ching-chih; Hernon, Peter

This two-part publication reports on a study of consumer information delivery by library and non-library networks, which involved an extensive literature review, a telephone survey of 620 library networks, the development of an assessment model for the effectiveness of network information delivery, the development of an in-depth guide for…

Vascular knowledge in medieval times was the turning point for the humanistic trend.

PubMed

Ducasse, E; Speziale, F; Baste, J C; Midy, D

2006-06-01

Knowledge of the history of our surgical specialty may broaden our viewpoint for everyday practice. We illustrate the scientific progress made in medieval times relevant to the vascular system and blood circulation, progress made despite prevailing religious and philosophical dogma. We located all articles concerning vascular knowledge and historical reviews in databases such as MEDLINE, EMBASE and the database of abstracts of reviews (DARE). We also explored the database of the register from the French National Library, the French Medical Inter-University (BIUM), the Italian National Library and the French and Italian Libraries in the Vatican. All data were collected and analysed in chronological order. Medieval vascular knowledge was inherited from Greek via Byzantine and Arabic writings, the first controversies against the recognized vascular schema emanating from an Arabian physician in the 13th century. Dissection was forbidden and clerical rules instilled a fear of blood. Major contributions to scientific progress in the vascular field in medieval times came from Ibn-al-Nafis and Harvey. Vascular specialists today may feel proud to recall that once religious dogma declined in early medieval times, vascular anatomic and physiological discoveries led the way to scientific progress.

Capturing the 'ome': the expanding molecular toolbox for RNA and DNA library construction.

PubMed

Boone, Morgane; De Koker, Andries; Callewaert, Nico

2018-04-06

All sequencing experiments and most functional genomics screens rely on the generation of libraries to comprehensively capture pools of targeted sequences. In the past decade especially, driven by the progress in the field of massively parallel sequencing, numerous studies have comprehensively assessed the impact of particular manipulations on library complexity and quality, and characterized the activities and specificities of several key enzymes used in library construction. Fortunately, careful protocol design and reagent choice can substantially mitigate many of these biases, and enable reliable representation of sequences in libraries. This review aims to guide the reader through the vast expanse of literature on the subject to promote informed library generation, independent of the application.

Plans and progress for building a Great Lakes fauna DNA barcode reference library

EPA Science Inventory

DNA reference libraries provide researchers with an important tool for assessing regional biodiversity by allowing unknown genetic sequences to be assigned identities, while also providing a means for taxonomists to validate identifications. Expanding the representation of Great...

78 FR 21969 - Gulf of Mexico (GOM), Outer Continental Shelf (OCS), Western Planning Area (WPA) Lease Sale 233...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-12

... while ensuring availability of the document to the public, BOEM will primarily distribute digital copies... copies of the Final Supplemental EIS to several libraries along the Gulf Coast. To find out which libraries have copies of the Final Supplemental EIS for review, you may contact BOEM's Public Information...

Design and Testing of a Method to Reach Agreement for Responsibilities in Collection Building Among Libraries. Final Report.

ERIC Educational Resources Information Center

Redfield, Gretchen

As a first step towards resource sharing among libraries in the Cleveland Area Metropolitan Library System (CAMLS), a unique method, called the Site Appraisal for Area Resources Inventory (SAFARI), was developed to examine the library collections. This approach was different than others in that collections were compared by experts in a specific…

Classified Information and Technical Libraries. Final Report. Army Technical Library Improvement Studies (ATLIS), Report No. 11.

ERIC Educational Resources Information Center

Luger, Herbert P.; Booser, Ronald J.

A survey of the literature in the last ten years and interviews with library and security personnel indicated: (1)the problems of handling classified information in libraries have been scanted; (2) there is wide divergence in policies and practices of disseminating such materials; (3)interlibrary cooperation with respect to classified holdings is…

Research on the Impact of a Computerized Circulation System on the Performance of a Large College Library. Final Report.

ERIC Educational Resources Information Center

Frohmberg, Katherine A.; Moffett, William A.

In order to study the effects of introducing an automated circulation system at Oberlin College, Ohio, data were collected from September 1978 until June 1982 on book availability, usage of library facilities, attitudes of library users toward the library, and the efficiency of circulation activities. Data collection methods included circulation…

A Prototype System for a Computer-Based Statewide Film Library Network: A Model for Operation. Final Report.

ERIC Educational Resources Information Center

Bidwell, Charles M.; Auricchio, Dominick

The project set out to establish an operational film scheduling network to improve service to New York State teachers using 16mm educational films. The Network is designed to serve local libraries located in Boards of Cooperative Educational Services (BOCES), regional libraries, and a statewide Syracuse University Film Rental Library (SUFRL). The…

Ouachita Parish Public Library, Final Performance Report for Library Services and Construction Act (LSCA) Title VI, Library Literacy Program, 1992-1993.

ERIC Educational Resources Information Center

Camp, Gloria S.

The Ouachita Parish Public Library (Louisiana) conducted a project that involved recruitment, coalition building, public awareness, training, basic literacy, collection development, tutoring, technology, and English as a Second Language (ESL) programs. The project served a community of over 200,000 people, and targeted the learning disabled,…

77 FR 42761 - Final Environmental Impact Statement for the Oil and Gas Management Plan at Big South Fork...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-20

... conducted in a manner that protects park resources and values, visitor use and experience, and human health... following libraries: McCreary County Public Library 6 North Main Whitley City, KY 42653 Oneida Public Library 290 South Main Street Oneida, TN 37841-2607 Fentress County Public Library 306 South Main Street...

Sri Lanka--Canada School Library & Information Services Programme Components: A School Library Study Tour. Final Report.

ERIC Educational Resources Information Center

Brown, Gerald R.

This document reports on a study tour of Canadian schools conducted by the Sri Lanka Ministry of Education. The purposes of the tour were to: develop an awareness of the scope of modern school library programming; investigate the aspects of implementation of a modern school library program including staffing, facilities, educational programming,…

Improving medical education in Kenya: an international collaboration.

PubMed

Mayo, Alexa

2014-04-01

This paper describes a partnership between the University of Nairobi College of Health Sciences (CHS) Library and the University of Maryland Health Sciences and Human Services Library (HS/HSL). The libraries are collaborating to develop best practices for the CHS Library as it meets the challenge of changing medical education information needs in a digital environment. The collaboration is part of a Medical Education Partnership Initiative. The library project has several components: an assessment of the CHS Library, learning visits in the United States and Kenya, development of recommendations to enhance the CHS Library, and ongoing evaluation of the program's progress. Development of new services and expertise at the CHS Library is critical to the project's success. A productive collaboration between the HS/HSL and CHS Library is ongoing. A successful program to improve the quality of medical education will have a beneficial impact on health outcomes in Kenya.

Improving medical education in Kenya: an international collaboration*†

PubMed Central

Mayo, Alexa

2014-01-01

This paper describes a partnership between the University of Nairobi College of Health Sciences (CHS) Library and the University of Maryland Health Sciences and Human Services Library (HS/HSL). The libraries are collaborating to develop best practices for the CHS Library as it meets the challenge of changing medical education information needs in a digital environment. The collaboration is part of a Medical Education Partnership Initiative. The library project has several components: an assessment of the CHS Library, learning visits in the United States and Kenya, development of recommendations to enhance the CHS Library, and ongoing evaluation of the program's progress. Development of new services and expertise at the CHS Library is critical to the project's success. A productive collaboration between the HS/HSL and CHS Library is ongoing. A successful program to improve the quality of medical education will have a beneficial impact on health outcomes in Kenya. PMID:24860265

Adaptive Technologies for Accommodating Persons with Disabilities.

ERIC Educational Resources Information Center

Berliss, Jane; And Others

1993-01-01

Eight articles review the progress achieved in making library computing technologies and library services accessible to people with disabilities. Adaptive technologies, automated conversion into Braille, and successful programs that demonstrate compliance with the American with Disabilities Act are described. A resource list is included. (EA)

Audiovisual in Libraries; the Past.

ERIC Educational Resources Information Center

Clement, Evelyn G.

By the first decade of the twentieth century, libraries were collecting pictures, post cards, clippings, recordings, music rolls, and stereographs. Circulation of these materials was often restricted, however. A number of progressive librarians stressed the acceptance of nonprinted materials as complementary to the book medium to the library…

Proven in vitro evolution of protease cathepsin E-inhibitors and -activators at pH 4.5 using a paired peptide method.

PubMed

Kitamura, Koichiro; Komatsu, Masayuki; Biyani, Madhu; Futakami, Masae; Kawakubo, Tomoyo; Yamamoto, Kenji; Nishigaki, Koichi

2012-12-01

Improving a particular function of molecules is often more difficult than identifying such molecules ab initio. Here, a method to acquire higher affinity and/or more functional peptides was developed as a progressive library selection method. The primary library selection products were utilized to build a secondary library composed of blocks of 4 amino acids, of which selection led to peptides with increased activity. These peptides were further converted to randomly generate paired peptides. Cathepsin E-inhibitors thus obtained exhibited the highest activities and affinities (pM order). This was also the case with cathepsin E-activating peptides, proving the methodological effectiveness. The primary, secondary, and tertiary library selections can be regarded as module-finding, module-shuffling, and module-pairing, respectively, which resembles the progression of the natural evolution of proteins. The mode of peptide binding to their target proteins is discussed in analogy to antibodies and epitopes of an antigen. Copyright © 2012 European Peptide Society and John Wiley & Sons, Ltd.

FRBR and School Libraries

ERIC Educational Resources Information Center

Hart, Amy

2006-01-01

This article discusses the Functional Requirements for Bibliographic Records (FRBR), a plan that is quickly gaining the support of library organizations around the globe. The FRBR Study Group was appointed by International Federation of Library Associations (IFLA) and issued its final report in 1998. The report redefines the basic unit of…

Standards for the academic veterinary medical library

PubMed Central

Murphy, Sarah Anne; Bedard, Martha A.; Crawley-Low, Jill; Fagen, Diane; Jette, Jean-Paul

2005-01-01

The Standards Committee of the Veterinary Medical Libraries Section was appointed in May 2000 and charged to create standards for the ideal academic veterinary medical library, written from the perspective of veterinary medical librarians. The resulting Standards for the Academic Veterinary Medical Library were approved by members of the Veterinary Medical Libraries Section during MLA '03 in San Diego, California. The standards were approved by Section Council in April 2005 and received final approval from the Board of Directors of the Medical Library Association during MLA '04 in Washington, DC. PMID:15685288

The Library of Congress: Evaluation of the NLS/BPH Braille and Audio Magazine Program. Final Project Report.

ERIC Educational Resources Information Center

Bosma and Associates International, Seattle, WA.

This final report presents an independent formative and summative evaluation of the National Library Services for the Blind and Physically Handicapped (NLS/BPH) braille and audio magazine program. In this program, 77 magazines are distributed directly to subscribers, with 43 magazines available on audio flexible discs and 34 magazines available in…

Acquisition of Scientific Literature in Developing Countries. 2: Malaysia.

ERIC Educational Resources Information Center

Taib, Rosna

1989-01-01

Describes the acquisition of scientific literature by academic libraries in Malaysia. The discussion covers the impact of government policies, library acquisition policies, the selection process, acquisition of special materials, the role of gifts and exchanges, and problems with customs clearance and censorship. Progress in cooperative…

Montana Certification Program Manual.

ERIC Educational Resources Information Center

Montana State Library, Helena.

The Montana Certification Program offers librarians, library staff members, and trustees a systematic and progressive method by which to track their continuing education (CE) efforts; the program also offers library boards and managers an opportunity to recognize staff efforts to improve their skills, ability, and knowledge. This first section of…

Harlan County Public Library, Final Performance Report for Library Services and Construction Act (LSCA) Title VI, Library Literacy Program.

ERIC Educational Resources Information Center

Warren, Carol E.

The Harlan County Public Library Literacy Project (Kentucky) provided rural-oriented, basic literacy, and oral history programs to a community of 100,000-200,000. The goal of the project was to produce six booklets about local people and issues, to be used as literacy materials in programs with Appalachian students. Students wanted to produce…

Special Libraries, Problems and Cooperative Potentials; Prepared for the National Advisory Commission on Libraries. Final Report.

ERIC Educational Resources Information Center

Havlik, Robert J.; And Others

A three part approach was taken in this situation report on the role of the special libraries in the United States. First, several background papers were prepared about the definition and state-of-the-art of the field of special librarianship. These papers are: (1) Shera, Jesse H., "Special Libraries--Why 'Special'?, (2) Ash, Lee,…

Clear Purpose...Complete Commitment. A Long-Range Program To Provide Louisianians with Library and Information Services Adequate to Their Needs, 1990/91-1995.

ERIC Educational Resources Information Center

Jaques, Thomas F.

This long-range library program for the state of Louisiana identifies specific inadequacies in public library services, resources, facilities, and personnel. It identifies the people who are to be served, and reveals geographical, socioeconomic, and educational barriers to the expanded use of libraries. Finally, it presents specific goals and…

An Evaluation of the El Centro de la Causa Library and Information Center: August 1973 through July 1974. Final Report.

ERIC Educational Resources Information Center

Michael, Mary Ellen; Encarnacion, Leticia

An evaluation of Chicago's El Centro de la Causa Library and Information Center was undertaken by the University of Illinois Library Research Center in 1974. Evaluation methods included: (1) a survey of user and nonuser characteristics and attitudes concerning library services; (2) a survey of the needs and information-seeking behavior of people…

Preliminary Specifications (Hardware and Software) for a Center for Information Services. Final Report on Mechanized Information Services in the University Library, Phase I - Planning. Part 10.

ERIC Educational Resources Information Center

California Univ., Los Angeles. Inst. of Library Research.

The general conclusions of the planning study on Mechanized Information Services in the University Library are that such services represent a desirable, even necessary, extension of the library's traditional functions. Preliminary specifications for such a library-based "Center for Information Services" (CIS) are presented in this report. Covered…

Multi-Threaded DNA Tag/Anti-Tag Library Generator for Multi-Core Platforms

DTIC Science & Technology

2009-05-01

base pair)  Watson ‐ Crick  strand pairs that bind perfectly within pairs, but poorly across pairs. A variety  of  DNA  strand hybridization metrics...AFRL-RI-RS-TR-2009-131 Final Technical Report May 2009 MULTI-THREADED DNA TAG/ANTI-TAG LIBRARY GENERATOR FOR MULTI-CORE PLATFORMS...TYPE Final 3. DATES COVERED (From - To) Jun 08 – Feb 09 4. TITLE AND SUBTITLE MULTI-THREADED DNA TAG/ANTI-TAG LIBRARY GENERATOR FOR MULTI-CORE

CD ROM (Compact Disc Read Only Memory): Potential Uses at Air University.

DTIC Science & Technology

1988-04-01

5 Library Science .................................... 6 Medicine........................................... 7 Law...publishing, business, education, library science , medicine, law, weather, cartography, and navigation will be discussed. Finally, Chapter One will conclude...substantial impact in the following disciplines: publishing, business, education, library science , medicine, law, weather and cartography. This portion of 4

77 FR 74472 - Notice of Availability of the Final Tank Closure and Waste Management Environmental Impact...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-14

... Rooms Gonzaga University, Foley Center Library, 101-L East 502 Boone, Spokane, Washington 99258, (509) 313-5931. Portland State University, Government Information, Branford Price Millar Library, 1875 SW Park Avenue, Portland, Oregon 97201, (503) 725- 5874. University of Washington, Suzzallo-Allen Library...

Telefax Library Information Network. Final Report.

ERIC Educational Resources Information Center

Denver Univ., CO. Graduate School of Librarianship and Information Management.

A demonstration project was undertaken to determine whether 1978 telefacsimile technology could address the needs of rural public libraries in a cost-effective manner. The TALINET design utilized local public library staff and a research/resource information staff at the University of Denver to research questions and deliver information to five…

75 FR 34151 - Availability: Final Comprehensive Conservation Plan and Finding of No Significant Impact; Modoc...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-16

... National Wildlife Refuge, 5364 County Road 115, Alturas, CA 96101. Local Library or Libraries: The documents are also available for review at the libraries listed under SUPPLEMENTARY INFORMATION. FOR MORE... management purposes, for migratory birds, for incidental fish and wildlife- oriented recreational development...

Time Management Study in Academic Libraries. Final Report.

ERIC Educational Resources Information Center

Gothberg, Helen M.; Riggs, Donald E.

This study was undertaken to generate and analyze survey data for evaluating time management practices among directors of large academic libraries. Questionnaires were mailed to 194 library directors and the 159 survey respondents (82%) provided information about their experience and other characteristics; how they allocate their time; to what…

Literacy Is VITAL. Final Report.

ERIC Educational Resources Information Center

Gillfillan, Nancy M.

Via an LSCA (Library Services and Construction Act) Title VI Library Literacy grant for fiscal year 1986, the Dixon (Illinois) Public Library expanded its involvement in the literacy effort. Additional rooms were made available for tutoring, materials and equipment for literacy students and books and equipment for literacy tutors were provided,…

Iranian Special Library Standards.

ERIC Educational Resources Information Center

Harvey, John F.

The purposes of these standards are: (1) to suggest the steps necessary for the establishment of special libraries; (2) for those recently established, to suggest the steps necessary to achieve satisfactory performance levels in all areas, and finally, (3) for well established libraries, to suggest the steps necessary to achieve excellence. These…

Center for Research Libraries Study, Concordia University. Final Report.

ERIC Educational Resources Information Center

Tallon, J.

This discussion of the implementation of services related to the Center for Research Libraries (CRL) if Concordia University Libraries were to join CRL includes policies and procedures designed to assist Concordia in making effective use of CRL's services without sacrificing regular services or incurring large expenses in addition to the…

Peptide Transduction-Based Therapies for Prostate Cancer

DTIC Science & Technology

2004-06-01

using an M13 peptide phage display library. Initial screening of the library for transduction of tumors in vivo has identified peptides able to...marker conjugates may have to be tested. (Months 6-12, Year 1) Progress: These experiments have been initiated. Task 4. An M13 peptide phage display ... phage 12 amino acid control peptide display library (New England Biolabs, Beverly, MA ) was used. Briefly, One nude mouse bearing a human tumor line

Books and Reading and Singleness of Purpose.

ERIC Educational Resources Information Center

Neill, S. D.

1985-01-01

Argues that in an age of information overload, the public library role is to promote books and reading and warns that public libraries that focus on technologies and information services will become cogs in the engine of material progress rather than fulfilling their role as sources of knowledge. (19 references) (EJS)

Library Services for Australia: The Work of AACOBS.

ERIC Educational Resources Information Center

National Library of Australia, Canberra.

Activities of the Australian Advisory Council on Bibliographical Services (AACOBS) in 1976 included a series of initiatives designed to promote, improve, and systematise the provision of library and information services on a nation-wide basis. This report discusses work in the area of (1) bibliographical services--work in progress, control of…

Computerization of Library and Information Services in Mainland China.

ERIC Educational Resources Information Center

Lin, Sharon Chien

1994-01-01

Describes two phases of the automation of library and information services in mainland China. From 1974-86, much effort was concentrated on developing computer systems, databases, online retrieval, and networking. From 1986 to the present, practical progress became possible largely because of CD-ROM technology; and large scale networking for…

Follow the St. Petersburg College Library as They Enter the Blogosphere

ERIC Educational Resources Information Center

Mairn, Chad P.

2005-01-01

Libraries throughout history have utilized some method of communicating resources and services to their communities. Verbal communication progressed into newsletters, event calendars, bookmarks, and posters. More recently, technological advancements have allowed individuals to communicate ideas beyond the confined pages of a book or newsletter and…

In Defense of DEZ: LC's Perspective.

ERIC Educational Resources Information Center

Welsh, William J.

1987-01-01

The Deputy Librarian of Congress responds to a Library Journal editorial on the Library of Congress' role in the development of the diethyl zinc process in preservation technology. Safety issues, DEZ as prototype, progress and success claims, deciding which books to save, and why DEZ should be used are explained. (EM)

Library Research: Luxury or Necessity?

ERIC Educational Resources Information Center

Maguire, Carmel

2011-01-01

The necessity of library and information research is pointed up by referring to some of important categories of research now in progress. Reasons are advanced for the necessity such research in Australia and ways suggested in which students wishing to make a career research and practitioners anxious for research opportunities may be accommodated.…

Low track height standard cell design in iN7 using scaling boosters

NASA Astrophysics Data System (ADS)

Sherazi, S. M. Y.; Jha, C.; Rodopoulos, D.; Debacker, P.; Chava, B.; Matti, L.; Bardon, M. G.; Schuddinck, P.; Raghavan, P.; Gerousis, V.; Spessot, A.; Verkest, D.; Mocuta, A.; Kim, R. H.; Ryckaert, J.

2017-04-01

In this paper, standard cell design for iN7 CMOS platform technology targeting the tightest contacted poly pitch (CPP) of 42 nm and a metal pitch of 32 nm in the FinFET technology is presented. Three standard cell architectures for iN7, a 7.5-Track library, 6.5-Track library, and 6-Track library have been designed. Scaling boosters are introduced for the libraries progressively: first an extra MOL layer to enable an efficient layout of the three libraries starting with 7.5-Track library; second, fully self aligned gate contact is introduced for 6.5 and 6-Track library and third, 6-Track cell design includes a buried rail track for supply. The 6-Track cells are on average 5% and 45% smaller than the 6.5 and 7.5-Track cells, respectively.

Longview Public Library Final Performance Report for Library Services and Construction Act (LCSA) Title VI Library Literacy Program.

ERIC Educational Resources Information Center

Longview Public Library, WA.

Project Read at the Longview (Washington) Public Library conducted a program to maintain and expand the Family Literacy Center to provide a monitored tutoring site and family outreach program for a minimum of 75 adult learners and 40 tutors. Two projects were involved: (1) Project READ focused on adult learners with a one-on-one tutoring approach;…

The Science, Engineering and Technology Career Library Corner. Final report, February 1, 1995--January 31, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cole, P.R.

1996-03-01

A grant was made to install and pilot-test the Science, Engineering and Technology (SET) Career Library Corner at the New York Hall of Science. The SET Career Library Corner is located in a multi-media library setting where visitors can explore careers in a quiet, uninterrupted environment, in contrast to the original installation designed as a museum floor exhibit.

Design of an Automated Library Information Storage and Retrieval System for Library of Congress Division for the Blind and Physically Handicapped (DBPH). Final Report.

ERIC Educational Resources Information Center

Systems Architects, Inc., Randolph, MA.

A practical system for producing a union catalog of titles in the collections of the Library of Congress Division for the Blind and Physically Handicapped (DBPH), its regional network, and related agencies from a machine-readable data base is presented. The DBPH organization and operations and the associated regional library network are analyzed.…

The Library and Human Memory. Final Report on Mechanized Information Services in the University Library, Phase I - Planning. Part 13.

ERIC Educational Resources Information Center

Norman, Donald A.

This paper discusses the differences between the storage problems encountered in a large library and those encountered in the human memory. Some of the properties of the human memory system and some of the major issues which affect the interaction between human users and the existing library systems are outlined. The problem of browsing is used as…

Survey of Library and Information Problems in Correctional Institutions. Volume 1: Findings and Recommendations. ILR-73-008. Final Report.

ERIC Educational Resources Information Center

LeDonne, Marjorie

On-site visits were made to all federal and some state prisons in 10 selected states to provide current information on which decisions could be based for prison library and information services. The focus was on the broad issues of library goals and objectives, relationship of the library to the total institution and the outside community, the…

CASMO5 JENDL-4.0 and ENDF/B-VII.1beta4 libraries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rhodes, J.; Gheorghiu, N.; Ferrer, R.

2012-07-01

This paper details the generation of neutron data libraries for the CASMO5 lattice physics code based on the recently released JENDL-4.0 and ENDF/B-VII.1beta4 nuclear data evaluations. This data represents state-of-the-art nuclear data for late-2011. The key features of the new evaluations are briefly described along with the procedure for processing of this data into CASMO5, 586-energy group neutron data libraries. Finally some CASMO5 results for standard UO{sub 2} and MOX critical experiments for the two new libraries and the current ENDF/B-VII.0 CASMO5 library are presented including the B and W 1810 series, DIMPLE S06A, S06B, TCA reflector criticals with ironmore » plates and the PNL-30-35 MOX criticals. The results show that CASMO5 with the new libraries is performing well for these criticals with a very slight edge in results to the JENDL-4.0 nuclear data evaluation over the ENDF/B-VII.1beta4 evaluation. Work is currently underway to generate a CASMO5 library based on the final ENDF/B-VII.R1 evaluation released Dec. 22, 2011. (authors)« less

Demonstrating the financial impact of clinical libraries: a systematic review.

PubMed

Madden, Anne; Collins, Pamela; McGowan, Sondhaya; Stevenson, Paul; Castelli, David; Hyde, Loree; DeSanto, Kristen; O'Brien, Nancy; Purdon, Michelle; Delgado, Diana

2016-09-01

The purpose of this review is to evaluate the tools used to measure the financial value of libraries in a clinical setting. Searches were carried out on ten databases for the years 2003-2013, with a final search before completion to identify any recent papers. Eleven papers met the final inclusion criteria. There was no evidence of a single 'best practice', and many metrics used to measure financial impact of clinical libraries were developed on an ad hoc basis locally. The most common measures of financial impact were value of time saved, value of resource collection against cost of alternative sources, cost avoidance and revenue generated through assistance on grant submissions. Few papers provided an insight into the longer term impact on the library service resulting from submitting return on investment (ROI) or other financial impact statements. There are limited examples of metrics which clinical libraries can use to measure explicit financial impact. The methods highlighted in this literature review are generally implicit in the measures used and lack robustness. There is a need for future research to develop standardised, validated tools that clinical libraries can use to demonstrate their financial impact. © 2016 Health Libraries Group.

The medical matters wiki: building a library Web site 2.0.

PubMed

Robertson, Justin; Burnham, Judy; Li, Jie; Sayed, Ellen

2008-01-01

New and innovative information technologies drive the ever-evolving library profession. From clay tablet to parchment scroll to manufactured paper to computer screen pixel, information storage, retrieval, and delivery methods continue to evolve, and each advance irrevocably affects the way libraries, and librarians, work. The Internet has forever altered information and library science, both in theory and practice, but even within this context the progression continues. Though ambiguously defined, Web 2.0 offers a new outlook and new software, presenting librarians with potentially invaluable new tools and methods. This paper discusses the creation, implementation, and maintenance of a Web 2.0 technology, the wiki, as a resource tool for an academic biomedical library.

Age Analysis of Public Library Collections. Final Report.

ERIC Educational Resources Information Center

Wallace, Danny P.; And Others

The use of information regarding the ages of library items is a standard component of many approaches to weeding library collections, and has a long history in the literature of collection management. Current and past approaches to using aging information to make weeding decisions make use of very arbitrary decision criteria. This study examined…

School Library Resources Program. Final Report, 1983-1984.

ERIC Educational Resources Information Center

District of Columbia Public Schools, Washington, DC. Div. of Quality Assurance.

Data for this evaluation of the District of Columbia Public Schools (DCPS) School Library Resources Program as operated during the 1983-84 school year were collected via surveys of library media specialists and teachers. The stated objectives of the program scheduled for attainment by June 1984 called for planning a pilot program for…

Small Public Library Management

ERIC Educational Resources Information Center

Pearlmutter, Jane; Nelson, Paul

2012-01-01

Anyone at the helm of a small public library knows that every little detail counts. But juggling the responsibilities that are part and parcel of the job is far from easy. Finally, here's a handbook that includes everything administrators need to keep a handle on library operations, freeing them up to streamline and improve how the organization…

Supplementary Materials for State Penitentiary Library Project. Final Performance Report.

ERIC Educational Resources Information Center

Hull, Jane A.

This report describes how a Library Services and Construction Act (LSCA) Title VI Library Literacy Program grant was used to improve the literacy and coping skills of illiterate and functionally illiterate inmates incarcerated at the Mississippi State Penitentiary. A second objective of this literacy program was to produce an annotated…

Library Information System Time-Sharing (LISTS) Project. Final Report.

ERIC Educational Resources Information Center

Black, Donald V.

The Library Information System Time-Sharing (LISTS) experiment was based on three innovations in data processing technology: (1) the advent of computer time-sharing on third-generation machines, (2) the development of general-purpose file-management software and (3) the introduction of large, library-oriented data bases. The main body of the…

Personnel for Research Libraries; Qualifications, Responsibilities and Use. Final Report.

ERIC Educational Resources Information Center

Clark, Philip M.

The project was conceived to examine the current manpower situation in research libraries and to develop a methodological model for projecting future personnel needs. Eight academic research libraries were selected for investigation and three instruments developed to gather data toward these ends. A personal interview format was used to interview…

75 FR 26278 - The Register of Copyrights’ and the Copyright Royalty Judges’ authority to determine the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-11

... LIBRARY OF CONGRESS Copyright Office [Docket No. RF 2009-1B] The Register of Copyrights' and the...: Copyright Office, Library of Congress. ACTION: Final Order. SUMMARY: Two material questions of substantive..., 2010 David O. Carson, General Counsel. Before the U.S. Copyright Office Library of Congress Washington...

New Directions in Library and Information Science Education. Final Report. Volume 2.12: Library System Supplier Professional Competencies.

ERIC Educational Resources Information Center

Griffiths, Jose-Marie; And Others

This document contains validated activities and competencies needed by information professionals working in a library system supplier organization. The activities and competencies are organized according to the functions which information professionals working in such organizations perform: research and development; marketing; customer support;…

Catalogue Support Systems Study. Final Report for British Columbia Library Development Commission.

ERIC Educational Resources Information Center

MacDonald, R. W.; And Others

To determine the need for additional bibliographic resources in the libraries of British Columbia, Canada, an evaluation was undertaken which included visits to libraries and existing operational catalog support systems, and meetings with advisory committees. Recommendations included: (1) implementation of a province-wide, on-line catalog system;…

Progress has Stalled in U.S. Stroke Death Rates after Decades of Decline

MedlinePlus

... Library (PHIL) Progress has stalled in US stroke death rates after decades of decline More timely stroke ... cdc.gov/vitalsigns/stroke/infographic.html#graphic) Stroke death declines have stalled in 3 out of every ...

Design of a fragment library that maximally represents available chemical space.

PubMed

Schulz, M N; Landström, J; Bright, K; Hubbard, R E

2011-07-01

Cheminformatics protocols have been developed and assessed that identify a small set of fragments which can represent the compounds in a chemical library for use in fragment-based ligand discovery. Six different methods have been implemented and tested on Input Libraries of compounds from three suppliers. The resulting Fragment Sets have been characterised on the basis of computed physico-chemical properties and their similarity to the Input Libraries. A method that iteratively identifies fragments with the maximum number of similar compounds in the Input Library (Nearest Neighbours) produces the most diverse library. This approach could increase the success of experimental ligand discovery projects, by providing fragments that can be progressed rapidly to larger compounds through access to available similar compounds (known as SAR by Catalog).

Successes & Failures of Digital Libraries. Papers Presented at the Annual Clinic on Library Applications of Data Processing (35th, Champaign, Illinois, March 22-24, 1998).

ERIC Educational Resources Information Center

Harum, Susan, Ed.; Twidale, Michael, Ed.

This clinic's goal was to address questions arising during the process of transition from theory and research development to deployed useful and usable (and used) digital library systems. The idea was to use the Digital Libraries Initiative (DLI) based at the University of Illinois at Urbana-Champaign and entering its final year, as a detailed…

New on the Shelf: Teens in the Library. Findings from the Evaluation of Public Libraries as Partners in Youth Development, An Initiative of the Wallace Foundation. Final Report

ERIC Educational Resources Information Center

Spielberger, Julie; Horton, Carol; Michels, Lisa; Halpern, Robert

2004-01-01

Several trends have come together to intensify interest in how public libraries might best support the interests and needs of youth in their communities. This study reports on findings from the Public Libraries as Partners in Youth Development (PLPYD) Initiative, a four-year, nine-site initiative funded by the Wallace Foundation to develop…

Lessons from Library Power: Enriching Teaching and Learning. Final Report of the Evaluation of the National Library Power Initiative, an Initiative of the DeWitt Wallace-Reader's Digest Fund.

ERIC Educational Resources Information Center

Zweizig, Douglas L.; Hopkins, Dianne McAfee

This book presents the results of an evaluation of Library Power, an initiative of the DeWitt Wallace-Reader's Digest Fund that provided support for school library development in 19 communities. Following an introductory chapter, the chapters are organized around key questions of the evaluation. Chapters 2 through 4 address the implementation of…

Redesign of Library Workflows: Experimental Models for Electronic Resource Description.

ERIC Educational Resources Information Center

Calhoun, Karen

This paper explores the potential for and progress of a gradual transition from a highly centralized model for cataloging to an iterative, collaborative, and broadly distributed model for electronic resource description. The purpose is to alert library managers to some experiments underway and to help them conceptualize new methods for defining,…

Digitisation of Local Heritage: Local Studies Collections and Digitisation in Public Libraries

ERIC Educational Resources Information Center

Smith, Lucy; Rowley, Jennifer

2012-01-01

This study explores the application of digitisation in the context of public library local studies services. Since there has been limited previous research on digitisation and local studies collections, this research makes an important contribution in profiling the current situation, and highlighting the extent to which progress is limited in the…

Steps for Evaluating a Fifth Grade Science Collection

ERIC Educational Resources Information Center

Griffin, Gail Guidry

2011-01-01

A well balanced curriculum is an area of great concern in a school. With an enhanced collection, the library media specialist can further educational progress on all levels. Through accessing a good science collection in the library, students can achieve their learning goals. This article describes a process used to evaluate a science collection…

Bibliographical Work in New Zealand, 1980-1982. Work in Progress and Work Published.

ERIC Educational Resources Information Center

Millett, A. P. U., Comp.; Cole, F. T. H., Comp.

Formerly published as an irregular feature of New Zealand Libraries, these three annual bibliographies (1980, 1981, 1982) list bibliographical work in progress, as well as enumerative and subject bibliographies published in New Zealand from July 1977 to June 1982. It is noted that bibliographical work in progress is compiled from an annual…

Systems Design and Pilot Operation of a Regional Center for Technical Processing for the Libraries of the New England State Universities. NELINET, New England Library Information Network. Progress Report, July 1, 1967 - March 30, 1968, Volume II, Appendices.

ERIC Educational Resources Information Center

Agenbroad, James E.; And Others

Included in this volume of appendices to LI 000 979 are acquisitions flow charts; a current operations questionnaire; an algorithm for splitting the Library of Congress call number; analysis of the Machine-Readable Cataloging (MARC II) format; production problems and decisions; operating procedures for information transmittal in the New England…

76 FR 5145 - Notice of Availability of the Final Long-Term Management and Storage of Elemental Mercury...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-28

... are available for public review at the locations listed below. Colorado Mesa County Library, 530 Grand..., Washington, DC 20585, (202) 586-5955. Georgia Augusta State University, Reese Library, 2500 Walton Way, Augusta, GA 30904, (706) 737-1745. Savannah State University, Asa H. Gordon Library, 2200 Tompkins Road...

Analysis of the Midwest Medical Union Catalog. Final Report.

ERIC Educational Resources Information Center

Olson, Paul E.; Pletzke, Chester J.

A cost-benefit analysis of the 43-library, 260,000-title Midwest Medical Union Catalog (MMUC) of books, conducted from June, 1973, through May, 1975, under a grant from the National Library of Medicine, studied the 49-year-old catalog in the context of the interlibrary loan activity of the Midwest Health Science Library Network. The study tested…

Fort Berthold Library Literacy Program. Final Performance Report, October 1, 1988-September 30, 1989.

ERIC Educational Resources Information Center

Fort Berthold Reservation Public Library, New Town, ND.

The report describes activities of the Fort Berthold Reservation Public Library (North Dakota) Literacy Program to meet six objectives for the 1988-89 project year. The program was designed specifically to promote literacy among three Native American tribes, the Mandan, Hidatsa, and Arikara. Objectives included acquisition of a library literacy…

The School Library Supervisor and Her Situation. Final Report.

ERIC Educational Resources Information Center

Bundy, Mary Lee; And Others

In the study of the school library supervisor, the universe was made up of those school systems in the United States with enrollments of 25,000 or more and identified as having the position of school library supervisor. Questionnaires were sent to all 150 supervisors thus identified and 99 returned the questionnaire. Full detail of sample choice…

Being there: the library as place.

PubMed

Weise, Frieda

2004-01-01

The value of the library as place is examined in this Janet Doe Lecture. The lecture, which is intended to focus on the history or philosophy of health sciences librarianship, presents an overview of the library as a place in society from ancient times to the present. The impact of information technology and changes in the methods of scholarly publication from print to digital are addressed as well as the role of the library as the repository of the written historical record of cultures. Functions and services of libraries are discussed in light of the physical library facility of the future. Finally, librarians are asked to remember the enduring values of librarianship in planning libraries of the future.

Being there: the library as place*

PubMed Central

Weise, Frieda

2004-01-01

The value of the library as place is examined in this Janet Doe Lecture. The lecture, which is intended to focus on the history or philosophy of health sciences librarianship, presents an overview of the library as a place in society from ancient times to the present. The impact of information technology and changes in the methods of scholarly publication from print to digital are addressed as well as the role of the library as the repository of the written historical record of cultures. Functions and services of libraries are discussed in light of the physical library facility of the future. Finally, librarians are asked to remember the enduring values of librarianship in planning libraries of the future. PMID:14762459

Mixture-based combinatorial libraries from small individual peptide libraries: a case study on α1-antitrypsin deficiency.

PubMed

Chang, Yi-Pin; Chu, Yen-Ho

2014-05-16

The design, synthesis and screening of diversity-oriented peptide libraries using a "libraries from libraries" strategy for the development of inhibitors of α1-antitrypsin deficiency are described. The major buttress of the biochemical approach presented here is the use of well-established solid-phase split-and-mix method for the generation of mixture-based libraries. The combinatorial technique iterative deconvolution was employed for library screening. While molecular diversity is the general consideration of combinatorial libraries, exquisite design through systematic screening of small individual libraries is a prerequisite for effective library screening and can avoid potential problems in some cases. This review will also illustrate how large peptide libraries were designed, as well as how a conformation-sensitive assay was developed based on the mechanism of the conformational disease. Finally, the combinatorially selected peptide inhibitor capable of blocking abnormal protein aggregation will be characterized by biophysical, cellular and computational methods.

Human Resources in the Library System. Course 2, Study Guide. Final Report, Phase 2, Post-Master's Education for Middle and Upper-Level Personnel in Libraries and Information Centers.

ERIC Educational Resources Information Center

Goodman, Charles H.; Stone, Elizabeth W.

A study guide is presented for a course designed for the continuing education of professional librarians at the level of middle or upper management who find that they need understanding about human resources in the library system beyond that acquired on the job or in previous library education. The course has four units: (1) Management: A Systems…

Design of targeted libraries against the human Chk1 kinase using PGVL Hub.

PubMed

Peng, Zhengwei; Hu, Qiyue

2011-01-01

PGVL Hub is a Pfizer internal desktop tool for chemical library and singleton design. In this chapter, we give a short introduction to PGVL Hub, the core workflow it supports, and the rich design capabilities it provides. By re-creating two legacy targeted libraries against the human checkpoint kinase 1 (Chk1) as a showcase, we illustrate how PGVL Hub could be used to help library designers carry out the steps in library design and realize design objectives such as SAR expansion and improvement in both kinase selectivity and compound aqueous solubility. Finally we share several tips about library design and usage of PGVL Hub.

Quality ILL Service in the Network of CSIC Libraries: Five Years of Progress.

ERIC Educational Resources Information Center

Malo de Molina y Martin-Montalvo, Teresa; Quintana Martinez, Isabel

1997-01-01

Although Spanish interlibrary loans (ILL) have increased from 100 to 525 per 100,000 inhabitants, there are still many problems to resolve. Examines a plan developed by the Consejo Superior de Investigaciones Cientificas (CSIC) Library Network to improve ILL services. Provides a comparative analysis of ILL services from 1992-1995. Includes charts…

Historical Work in Mass Communication Studies: Literacy, Libraries, and Popular Reading.

ERIC Educational Resources Information Center

Inglesby, Pamela

Recent work in both the history of education and the influence of popular culture suggests that libraries can be studied as sites where the public is taught--through a variety of mechanisms--important lessons about communication, knowledge and society. Researchers have addressed the interpretive question of whether literacy is tied to progress and…

Working Paper on the Future of Library Automation at Stanford.

ERIC Educational Resources Information Center

Weber, David C.

A number of important factors require Stanford University to review the progress and future implications of technological innovations in the library for the community of scholars which it serves. These factors include: The general economic climate of the University in 1971 and in the immediate years ahead; The problem of future funding of the…

DEVELOPMENT OF AN ELECTROSPRAY LC/MS LIBRARY IDENTIFICATION PROTOCOL FOR THE SCREENING OF ORGANIC CONTAMINANTS IN DRINKING WATER

EPA Science Inventory

A significant number (80%) of organic contaminants that represent health risks in drinking water are better suited to screening by LC/MS rather than GC/MS analysis. We report progress with the draft Library System Protocol 1.1 from a round robin of private, state and federal lab...

Developing and Managing a Local Digital Archive for Integrated Access to Journals and Other Publications.

ERIC Educational Resources Information Center

Stackpole, Laurie

2001-01-01

The Naval Research Laboratory Library has made significant progress providing its distributed user community with a single point-of-access to information needed to support scientific research through TORPEDO "Ultra," a digital archive that in many respects functions as an electronic counterpart of a traditional library. It consists of…

The Public Library Administrator and His Situation. Final Report.

ERIC Educational Resources Information Center

Bundy, Mary Lee; And Others

In this study of the public library administrator the universe was made up of public libraries serving populations of 100,000 or more. A total of 102 administrators responded to the questionnaire. Full details of sample choice and design and an analysis of the returns are contained in the Appendix. A primary concern was to discern where and how…

User Requirements in Identifying Desired Works in a Large Library. Final Report.

ERIC Educational Resources Information Center

Lipetz, Ben-Ami

Utilization of the card catalog in the main library (Sterling Memorial Library) of Yale University was studied over a period of more than a year. Traffic flow in the catalog was observed, and was used as the basis for scheduling interviews with a representative sample of catalog users at the moment of catalog use. More than 2000 interviews were…

The Role of Libraries in Lifelong Learning. Final Report of the IFLA Project under the Section for Public Libraries

ERIC Educational Resources Information Center

Haggstrom, Britt Marie, Ed.

2004-01-01

The fifth UNESCO/CONFINTEA meeting took place in Hamburg in 1997. The Hamburg declaration was adopted and stated that "UNESCO should strengthen libraries, museums heritage and cultural institutions as learning places and partners in the lifelong learning process and modern citizenship" It was felt that IFLA (International Federation of…

77 FR 27111 - Office of Commercial Space Transportation (AST); Notice of Availability of the Final...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-08

... Policy Act of 1969, as amended (NEPA; 42 U.S.C. 4321 et seq.), Council on Environmental Quality NEPA... Base Library, 95 SPTG/SVMG, 5 West Yeager Blvd., Building 2665, Edwards AFB, CA 93524-1295. Kern County Library, Boron Branch, 26967 20 Mule Team Road, Boron, CA 93516. Kern County Library, California City...

The Research Library's Role in Digital Repository Services: Final Report of the ARL Digital Repository Issues Task Force

ERIC Educational Resources Information Center

Association of Research Libraries, 2009

2009-01-01

Libraries are making diverse contributions to the development of many types of digital repositories, particularly those housing locally created digital content, including new digital objects or digitized versions of locally held works. In some instances, libraries are managing a repository and its related services entirely on their own, but often…

Coordinated Collection Development via CD-ROM. A Pilot Project Granted by LSCA Title III Funds to Crosby Library, Gonzaga University. Final Narrative Report.

ERIC Educational Resources Information Center

Peterson, Elaine; Carr, Mary M.

Three colleges in the state of Washington--Gonzaga College (Crosby Library), Whitworth College, and Eastern Washington University--received grants from the Fred Meyer Charitable Trust and the Library Services and Construction Act to facilitate coordinated collection development in the areas of education and business/economics, so that their…

Clear Purpose...Complete Commitment: A Long-Range Program To Provide Louisianians with Library and Information Services Adequate to Their Needs, 1992-1996.

ERIC Educational Resources Information Center

Jaques, Thomas F.

This report identifies specific inadequacies in Louisiana public library services, resources, facilities, and personnel. It also identifies the people who are to be served, and reveals the geographical, sociological, economic, and educational barriers to the expanded use of libraries. Finally, it presents specific goals and objectives as part of…

Therapy Dogs in Academic Libraries: A Way to Foster Student Engagement and Mitigate Self-Reported Stress during Finals

ERIC Educational Resources Information Center

Jalongo, Mary Renck; McDevitt, Theresa

2015-01-01

More and more modern academic libraries are turning to student engagement activities designed to welcome students into Academia, join a community of scholars, and avail themselves of the full range of resources and services that a university library can provide. One unusual, but inexpensive and highly effective method of engaging students is…

Museums and Libraries Engaging America's Youth: Final Report of a Study of IMLS Youth Programs, 1998-2003

ERIC Educational Resources Information Center

Koke, Judy; Dierking, Lynn

2007-01-01

The Institute of Museum and Library Services (IMLS) helps museums and libraries preserve our cultural heritage, enhance learning and innovation, and develop staff capacities to provide the best in service to our communities. IMLS has a long-standing commitment to funding grants and sponsoring research on the subject of how both preschool and…

Human Resources in the Library System. Course 2, Leader's Handbook, Part 1: Designs for Learning. Final Report, Phase 2, Post-Master's Education for Middle and Upper-Level Personnel in Libraries and Information Centers.

ERIC Educational Resources Information Center

Goodman, Charles H.; Stone, Elizabeth W.

A leader's handbook is presented for a course designed for the continuing education of professional librarians at the level of middle or upper management who find that they need understanding about human resources in the library system beyond that acquired on the job or in previous library education. The course has four units: (1) Management: A…

Multiple views of the October 2003 Cedar Fires captured by the High Performance Wireless Research and Education Network

NASA Astrophysics Data System (ADS)

Morikawa, E.; Nayak, A.; Vernon, F.; Braun, H.; Matthews, J.

2004-12-01

Late October 2003 brought devastating fires to the entire Southern California region. The NSF-funded High Performance Wireless Research and Education Network (HPWREN - http://hpwren.ucsd.edu/) cameras captured the development and progress of the Cedar fire in San Diego County. Cameras on Mt. Laguna, Mt. Woodson, Ramona Airport, and North Peak, recording one frame every 12 seconds, allowed for a time-lapse composite showing the fire's formation and progress from its beginnings on October 26th, to October 30th. The time-lapse camera footage depicts gushing smoke formations during the day, and bright orange walls of fire at night. The final video includes time synchronized views from multiple cameras, and an animated map highlighting the progress of the fire over time, and a directional indicator for each of the displaying cameras. The video is narrated by the California Department of Forestry and Fire Protection Fire Captain Ron Serabia (retd.) who was working then as a Air Tactical Group Supervisor with the aerial assault on the Cedar Fire Sunday October 26, 2004. The movie will be made available for download from the Scripps Institution of Oceanography Visualization Center Visual Objects library (supported by the OptIPuter project) at http://www.siovizcenter.ucsd.edu.

Little by Little Does the Trick: Design and Construction of a Discrete Event Agent-Based Simulation Framework

DTIC Science & Technology

2007-12-01

model. Finally, we build a small agent-based model using the component architecture to demonstrate the library’s functionality. 15. NUMBER OF...and a Behavioral model. Finally, we build a small agent-based model using the component architecture to demonstrate the library’s functionality...prototypes an architectural design which is generalizable, reusable, and extensible. We have created an initial set of model elements that demonstrate

Definition of natural T cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries.

PubMed

Hiemstra, H S; van Veelen, P A; Schloot, N C; Geluk, A; van Meijgaarden, K E; Willemen, S J; Leunissen, J A; Benckhuijsen, W E; Amons, R; de Vries, R R; Roep, B O; Ottenhoff, T H; Drijfhout, J W

1998-10-15

Progress has recently been made in the use of synthetic peptide libraries for the identification of T cell-stimulating ligands. T cell epitopes identified from synthetic libraries are mimics of natural epitopes. Here we show how the mimicry epitopes obtained from synthetic peptide libraries enable unambiguous identification of natural T cell Ags. Synthetic peptide libraries were screened with Mycobacterium tuberculosis-reactive and -autoreactive T cell clones. In two cases, database homology searches with mimicry epitopes isolated from a dedicated synthetic peptide library allowed immediate identification of the natural antigenic protein. In two other cases, an amino acid pattern that reflected the epitope requirements of the T cell was determined by substitution and omission mixture analysis. Subsequently, the natural Ag was identified from databases using this refined pattern. This approach opens new perspectives for rapid and reliable Ag definition, representing a feasible alternative to the biochemical and genetic approaches described thus far.

The identification of high-affinity G protein-coupled receptor ligands from large combinatorial libraries using multicolor quantum dot-labeled cell-based screening

PubMed Central

Fu, Junjie; Lee, Timothy; Qi, Xin

2014-01-01

G protein-coupled receptors (GPCRs), which are involved in virtually every biological process, constitute the largest family of transmembrane receptors. Many top-selling and newly approved drugs target GPCRs. In this review, we aim to recapitulate efforts and progress in combinatorial library-assisted GPCR ligand discovery, particularly focusing on one-bead-one-compound library synthesis and quantum dot-labeled cell-based assays, which both effectively enhance the rapid identification of GPCR ligands with higher affinity and specificity. PMID:24941874

Sequence-independent construction of ordered combinatorial libraries with predefined crossover points.

PubMed

Jézéquel, Laetitia; Loeper, Jacqueline; Pompon, Denis

2008-11-01

Combinatorial libraries coding for mosaic enzymes with predefined crossover points constitute useful tools to address and model structure-function relationships and for functional optimization of enzymes based on multivariate statistics. The presented method, called sequence-independent generation of a chimera-ordered library (SIGNAL), allows easy shuffling of any predefined amino acid segment between two or more proteins. This method is particularly well adapted to the exchange of protein structural modules. The procedure could also be well suited to generate ordered combinatorial libraries independent of sequence similarities in a robotized manner. Sequence segments to be recombined are first extracted by PCR from a single-stranded template coding for an enzyme of interest using a biotin-avidin-based method. This technique allows the reduction of parental template contamination in the final library. Specific PCR primers allow amplification of two complementary mosaic DNA fragments, overlapping in the region to be exchanged. Fragments are finally reassembled using a fusion PCR. The process is illustrated via the construction of a set of mosaic CYP2B enzymes using this highly modular approach.

Enriching peptide libraries for binding affinity and specificity through computationally directed library design

PubMed Central

Foight, Glenna Wink; Chen, T. Scott; Richman, Daniel; Keating, Amy E.

2017-01-01

Peptide reagents with high affinity or specificity for their target protein interaction partner are of utility for many important applications. Optimization of peptide binding by screening large libraries is a proven and powerful approach. Libraries designed to be enriched in peptide sequences that are predicted to have desired affinity or specificity characteristics are more likely to yield success than random mutagenesis. We present a library optimization method in which the choice of amino acids to encode at each peptide position can be guided by available experimental data or structure-based predictions. We discuss how to use analysis of predicted library performance to inform rounds of library design. Finally, we include protocols for more complex library design procedures that consider the chemical diversity of the amino acids at each peptide position and optimize a library score based on a user-specified input model. PMID:28236241

Enriching Peptide Libraries for Binding Affinity and Specificity Through Computationally Directed Library Design.

PubMed

Foight, Glenna Wink; Chen, T Scott; Richman, Daniel; Keating, Amy E

2017-01-01

Peptide reagents with high affinity or specificity for their target protein interaction partner are of utility for many important applications. Optimization of peptide binding by screening large libraries is a proven and powerful approach. Libraries designed to be enriched in peptide sequences that are predicted to have desired affinity or specificity characteristics are more likely to yield success than random mutagenesis. We present a library optimization method in which the choice of amino acids to encode at each peptide position can be guided by available experimental data or structure-based predictions. We discuss how to use analysis of predicted library performance to inform rounds of library design. Finally, we include protocols for more complex library design procedures that consider the chemical diversity of the amino acids at each peptide position and optimize a library score based on a user-specified input model.

Introducing Public Libraries to The Big Read: Final Report on the Audio Guide Distribution

ERIC Educational Resources Information Center

Sloan, Kay; Randall, Michelle

2009-01-01

In July 2008, over 14,000 public libraries throughout the U.S. received, free of charge, a set of fourteen Audio Guides introducing them to The Big Read. Since 2007, when the National Endowment for the Arts and the Institute of Museum and Library Services, in partnership with Arts Midwest, debuted The Big Read, the program has awarded grants to…

Transportation library connectivity pooled fund study, TPF-5(105).

DOT National Transportation Integrated Search

2010-10-01

This report is a record of the formation, major activities and accomplishments of the Transportation Library Connectivity : pooled fund study, TPF-5(105), from its approval by FHWA in 2005 through its fifth and final annual meeting in September : 201...

Where Library History Meets the Future: Proceedings of the 43rd Annual Military Librarians Workshop

DTIC Science & Technology

2001-04-04

way things turn out.” Prusak’s final advice at SLA in June—“Don’t stick with library science stuff, but understand how your organization will be...gives the written subject-matter test in library science to persons seeking to qualify for GS 1410 Librarian series positions. Persons who want to...the Army’s practice to recruit librarians with Masters in Library Science “ it is neither the policy nor the practice of the US ARMY to hire non

A Study with Computer-Based Circulation Data of the Non-Use and Use of a Large Academic Library. Final Report.

ERIC Educational Resources Information Center

Lubans, John, Jr.; And Others

Computer-based circulation systems, it is widely believed, can be utilized to provide data for library use studies. The study described in this report involves using such a data base to analyze aspects of library use and non-use and types of users. Another major objective of this research was the testing of machine-readable circulation data…

A Demonstration Pilot Project of Comprehensive Library Services for the Aged in Selected Communities in Kentucky (NRTA/AARP Kentucky Library Project). Final Report, Phase 1.

ERIC Educational Resources Information Center

Carlson, Lawrence O.

The project, intended to design and field test models of specialized library services for older adults, was conducted in two parts. Phase 1 consisted of collecting and evaluating data for use in designing models in Louisville, Lexington, Somerset, and Hazard, Kentucky. Data was collected by search of the literature, personal interviews, a…

Analysis of Requirements of On-Line Network Cataloging Services for Small, Academic, Public, School and Other Libraries: A Demonstration Project using the OCLC System. Final Report.

ERIC Educational Resources Information Center

Markuson, Barbara Evans

This report results from a project using the OCLC system to provide catalog services to small libraries. Alternatives described include: centralized cataloging, centralized book processing, sharing of OCLC terminals, and use of dial-up terminals. The OCLC data base was found useful for all types of small libraries. It is recommended that network…

Visual Image Transmission. An Examination of Electronic Delivery of Visual Images and Text from the Library to the Academic Community. Final Report.

ERIC Educational Resources Information Center

Smith, Merrill W.; And Others

Designed to examine the potential for delivering images stored on videodisc and other optical media from the library to the classroom, the pilot project described in this report has focused on ways to transmit still color or black and white images from the library's collection to a constituent academic unit. This report discusses analog and…

Libraries--Link To Learning. Final Report on the Indiana Governor's Conference on Libraries and Information Services (2nd, Indianapolis, Indiana, November 16-18, 1990).

ERIC Educational Resources Information Center

Henson, Jane E., Ed.

This report focuses on the three themes of the 1991 White House Conference on Library and Information Services, i.e., Democracy, Literacy, and Productivity. The report begins with an introduction by State Librarian Ray Ewick and a summary of the conference activities. Executive summaries of remarks made by speakers during three general conference…

Seminar on the Acquisition of Latin American Library Materials (15th, Toronto, Ontario, Canada, June 23-26, 1970). Final Report and Working Papers, Volume II.

ERIC Educational Resources Information Center

Benson, Susan Shattuck: Bresie, Mayellen

Volume 2 contains 13 working papers from the 15th Seminar on Acquisition of Latin American Library Materials. The papers are: (1) A Report on Bibliographic Activities; (2) Microfilm Projects Newsletter; (3) Role of Latin American Legal Material in the Social Science Research Library; (4) A description of sources for Legal and Social Science…

Central New York Library Resources Council CLRC Regional Digitization Plan. Final Report for the Preparing Central New York History for the Future LSTA Project.

ERIC Educational Resources Information Center

Sywetz, Betsy

The primary goal for digitization projects sponsored by the Central New York Library Resources Council (CLRC) is enhanced access for the people of the region to digital resources created from collections in Central New York's libraries, archives and museums. The CLRC Digitization Plan provides a framework for the support of digitization activities…

Finally! Distance Education for Library Support Staff.

ERIC Educational Resources Information Center

Rau, Kirk

1998-01-01

Discusses distance undergraduate education programs for paraprofessional librarians and suggests how to evaluate institutions: accreditation, academic program, communication, curriculum, and delivery methods. Highlights the AS degree in Library and Information Technology distance-education program offered by the University of Maine at Augusta.…

Discrete RNA libraries from pseudo-torsional space

PubMed Central

Humphris-Narayanan, Elisabeth

2012-01-01

The discovery that RNA molecules can fold into complex structures and carry out diverse cellular roles has led to interest in developing tools for modeling RNA tertiary structure. While significant progress has been made in establishing that the RNA backbone is rotameric, few libraries of discrete conformations specifically for use in RNA modeling have been validated. Here, we present six libraries of discrete RNA conformations based on a simplified pseudo-torsional notation of the RNA backbone, comparable to phi and psi in the protein backbone. We evaluate the ability of each library to represent single nucleotide backbone conformations and we show how individual library fragments can be assembled into dinucleotides that are consistent with established RNA backbone descriptors spanning from sugar to sugar. We then use each library to build all-atom models of 20 test folds and we show how the composition of a fragment library can limit model quality. Despite the limitations inherent in using discretized libraries, we find that several hundred discrete fragments can rebuild RNA folds up to 174 nucleotides in length with atomic-level accuracy (<1.5Å RMSD). We anticipate the libraries presented here could easily be incorporated into RNA structural modeling, analysis, or refinement tools. PMID:22425640

Library services for people with disabilities: results of a survey.

PubMed Central

Nelson, P P

1996-01-01

The Americans with Disabilities Act (ADA), enacted in 1990, has had a significant impact on the way many institutions, including libraries, do business. The Association of Research Libraries surveyed its members in 1991 to determine the effect of this legislation, and the author conducted a similar survey in 1995 to learn what progress academic health sciences libraries have made in serving the needs of people with disablities. A questionnaire was mailed to 131 members of the Association of Academic Health Sciences Library Directors. Nearly three-quarters of respondents reported elimination of physical barriers. The most common services provided are retrieval of materials from the stacks and photocopy assistance. Much less attention has been paid to the use of adaptive technology that allows disabled users to search a library's online catalog and databases; special technology is often provided by another unit on campus but there seems to be little coordination with library services Few libraries have assigned responsibility for disability services to a specific staff member and even fewer have done a formal assessment of the need for special services. The issues identified by the survey should challenge academic health sciences libraries to examine their status regarding compliance with ADA legislation. PMID:8883988

An Optimizing Compiler for Petascale I/O on Leadership Class Architectures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Choudhary, Alok; Kandemir, Mahmut

In high-performance computing systems, parallel I/O architectures usually have very complex hierarchies with multiple layers that collectively constitute an I/O stack, including high-level I/O libraries such as PnetCDF and HDF5, I/O middleware such as MPI-IO, and parallel file systems such as PVFS and Lustre. Our project explored automated instrumentation and compiler support for I/O intensive applications. Our project made significant progress towards understanding the complex I/O hierarchies of high-performance storage systems (including storage caches, HDDs, and SSDs), and designing and implementing state-of-the-art compiler/runtime system technology that targets I/O intensive HPC applications that target leadership class machine. This final report summarizesmore » the major achievements of the project and also points out promising future directions.« less

A Hartree-Fock Application Using UPC++ and the New DArray Library

DOE PAGES

Ozog, David; Kamil, Amir; Zheng, Yili; ...

2016-07-21

The Hartree-Fock (HF) method is the fundamental first step for incorporating quantum mechanics into many-electron simulations of atoms and molecules, and it is an important component of computational chemistry toolkits like NWChem. The GTFock code is an HF implementation that, while it does not have all the features in NWChem, represents crucial algorithmic advances that reduce communication and improve load balance by doing an up-front static partitioning of tasks, followed by work stealing whenever necessary. To enable innovations in algorithms and exploit next generation exascale systems, it is crucial to support quantum chemistry codes using expressive and convenient programming modelsmore » and runtime systems that are also efficient and scalable. Here, this paper presents an HF implementation similar to GTFock using UPC++, a partitioned global address space model that includes flexible communication, asynchronous remote computation, and a powerful multidimensional array library. UPC++ offers runtime features that are useful for HF such as active messages, a rich calculus for array operations, hardware-supported fetch-and-add, and functions for ensuring asynchronous runtime progress. We present a new distributed array abstraction, DArray, that is convenient for the kinds of random-access array updates and linear algebra operations on block-distributed arrays with irregular data ownership. Finally, we analyze the performance of atomic fetch-and-add operations (relevant for load balancing) and runtime attentiveness, then compare various techniques and optimizations for each. Our optimized implementation of HF using UPC++ and the DArrays library shows up to 20% improvement over GTFock with Global Arrays at scales up to 24,000 cores.« less

A Hartree-Fock Application Using UPC++ and the New DArray Library

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ozog, David; Kamil, Amir; Zheng, Yili

The Hartree-Fock (HF) method is the fundamental first step for incorporating quantum mechanics into many-electron simulations of atoms and molecules, and it is an important component of computational chemistry toolkits like NWChem. The GTFock code is an HF implementation that, while it does not have all the features in NWChem, represents crucial algorithmic advances that reduce communication and improve load balance by doing an up-front static partitioning of tasks, followed by work stealing whenever necessary. To enable innovations in algorithms and exploit next generation exascale systems, it is crucial to support quantum chemistry codes using expressive and convenient programming modelsmore » and runtime systems that are also efficient and scalable. Here, this paper presents an HF implementation similar to GTFock using UPC++, a partitioned global address space model that includes flexible communication, asynchronous remote computation, and a powerful multidimensional array library. UPC++ offers runtime features that are useful for HF such as active messages, a rich calculus for array operations, hardware-supported fetch-and-add, and functions for ensuring asynchronous runtime progress. We present a new distributed array abstraction, DArray, that is convenient for the kinds of random-access array updates and linear algebra operations on block-distributed arrays with irregular data ownership. Finally, we analyze the performance of atomic fetch-and-add operations (relevant for load balancing) and runtime attentiveness, then compare various techniques and optimizations for each. Our optimized implementation of HF using UPC++ and the DArrays library shows up to 20% improvement over GTFock with Global Arrays at scales up to 24,000 cores.« less

Empirical calibration of the near-infrared Ca ii triplet - I. The stellar library and index definition

NASA Astrophysics Data System (ADS)

Cenarro, A. J.; Cardiel, N.; Gorgas, J.; Peletier, R. F.; Vazdekis, A.; Prada, F.

2001-09-01

A new stellar library at the near-IR spectral region developed for the empirical calibration of the Caii triplet and stellar population synthesis modelling is presented. The library covers the range λλ8348-9020 at 1.5-Å (FWHM) spectral resolution, and consists of 706 stars spanning a wide range in atmospheric parameters. We have defined a new set of near-IR indices, CaT*, CaT and PaT, which mostly overcome the limitations of previous definitions, the former being specially suited for the measurement of the Caii triplet strength corrected for the contamination from Paschen lines. We also present a comparative study of the new and the previous Ca indices, as well as the corresponding transformations between the different systems. A thorough analysis of the sources of index errors and the procedure to calculate them is given. Finally, index and error measurements for the whole stellar library are provided together with the final spectra.

Availability of a library of infrared (2.1-25.0 microns) mineral spectra

NASA Technical Reports Server (NTRS)

Salisbury, John W.; Vergo, Norma; Walter, Louis S.

1989-01-01

All previously published libraries of infrared mineral spectra are in the form of transmitance. Reflectance spectra are, however, more useful for remote sensing and some potential laboratory applications, such as the use of an infrared microscope for mineral identification on polished sections. This note points out that construction of a new library of infrared (2.1-25.0 microns) mineral spectra is in progress. Both transmittance and reflectance measurements of a selection of 63 different, well-characterized minerals have been published to date. These data are available in both hard copy and digital form.

Degrees of Impact: Analyzing the Effects of Progressive Librarian Course Collaborations on Student Performance

ERIC Educational Resources Information Center

Booth, Char; Lowe, M. Sara; Tagge, Natalie; Stone, Sean M.

2015-01-01

The Claremont Colleges Library conducted direct rubric assessment of Pitzer College First-Year Seminar research papers to analyze the impact of diverse levels of librarian course collaborations on information literacy (IL) performance in student writing. Findings indicate that progressive degrees of librarian engagement in IL-related course…

A Safe and Welcoming Place?: Workplace Progression for Women Staff.

ERIC Educational Resources Information Center

Gardiner, Jean; O'Rourke, Rebecca

1995-01-01

Interviews with seven women lecturers and five administrative/library staff at Leeds University uncovered the following: differential career paths for women and men; a link between the extent of career progression and working full or part time; and few opportunities for gender issues to be openly discussed in the academic workplace. (SK)

Structure-Based Virtual Screening of Commercially Available Compound Libraries.

PubMed

Kireev, Dmitri

2016-01-01

Virtual screening (VS) is an efficient hit-finding tool. Its distinctive strength is that it allows one to screen compound libraries that are not available in the lab. Moreover, structure-based (SB) VS also enables an understanding of how the hit compounds bind the protein target, thus laying ground work for the rational hit-to-lead progression. SBVS requires a very limited experimental effort and is particularly well suited for academic labs and small biotech companies that, unlike pharmaceutical companies, do not have physical access to quality small-molecule libraries. Here, we describe SBVS of commercial compound libraries for Mer kinase inhibitors. The screening protocol relies on the docking algorithm Glide complemented by a post-docking filter based on structural protein-ligand interaction fingerprints (SPLIF).

Health Sciences Library Support of a University Common Reading Program: A Case Study.

PubMed

Delwiche, Frances A

2017-01-01

Common reading programs have become increasingly popular on college and university campuses as a means for increasing student engagement, retention, and success. This article describes the characteristics, goals, and benefits of common reading programs and provides examples from the literature of academic library involvement in them. Finally, an example is provided of how one academic health sciences library participated in its institution's First-Year Summer Reading program.

A New Strategic Direction for the AAHSLD Annual Statistics: Planning, Service Roles, Performance Measures, and Management Information Systems for Academic Health Science Libraries: Final Report for Phase I.

ERIC Educational Resources Information Center

McClure, Charles R.; And Others

This report presents a summary of activities, findings, and recommendations from Phase I of a project to improve the effectiveness of academic health science libraries and their provision of information services. The objectives for Phase I of the project are given: (1) to identify academic health science library requirements in the areas of…

Specifications of a Mechanized Center for Information Services for a Public Library Reference Center. Final Report. Part 1, Preliminary Specification: Mechanized Information Services in Public Library Reference Centers.

ERIC Educational Resources Information Center

California Univ., Los Angeles. Inst. of Library Research.

This document presents preliminary specifications for a library-based Center for Information Services (CIS). Four sets of issues are covered: (1) data base inventory, providing a listing of magnetic tape data bases now available from national sources or soon to be so; (2) administrative issues, including the organization of the CIS within the…

Assess and Invest: Faculty Feedback on Library Tutorials

ERIC Educational Resources Information Center

Appelt, Kristina M.; Pendell, Kimberly

2010-01-01

Communication and collaboration with faculty are increasingly important in the development of both curriculum-integrated and stand-alone "just in time" library tutorials. In the final developmental stages of the Evidence-Based Practice online tutorials, faculty members were asked to provide input during structured faculty feedback…

Information Literacy for the Skeptical Library Director.

ERIC Educational Resources Information Center

Breivik, Patricia S.

This paper begins by providing background on the information literacy movement, including the educational reform efforts of the 1980s, a higher education summit conference, and the 1989 American Library Association (ALA) Presidential Committee on Information Literacy Final Report. Other highlights include: the information literacy triangle;…

1991 survey of recent health sciences library building projects.

PubMed Central

Ludwig, L T

1992-01-01

Twenty health sciences libraries reported building planning, expansion, or construction of new facilities in the association's second annual survey of recent building projects. Six projects are new, freestanding structures in which the library occupies all or a major portion of the space. Six other projects are part of new construction for separately administered units in which the library is a major tenant. The final eight projects involve additions to or renovations of existing space. Seven of these twenty libraries were still in projected, predesign, or design stages of awaiting funding approval; of those seven, five were not prepared to release the requested information. Six projects are reported here as illustrative of current building projects. Images PMID:1600420

Construction of a scFv Library with Synthetic, Non-combinatorial CDR Diversity.

PubMed

Bai, Xuelian; Shim, Hyunbo

2017-01-01

Many large synthetic antibody libraries have been designed, constructed, and successfully generated high-quality antibodies suitable for various demanding applications. While synthetic antibody libraries have many advantages such as optimized framework sequences and a broader sequence landscape than natural antibodies, their sequence diversities typically are generated by random combinatorial synthetic processes which cause the incorporation of many undesired CDR sequences. Here, we describe the construction of a synthetic scFv library using oligonucleotide mixtures that contain predefined, non-combinatorially synthesized CDR sequences. Each CDR is first inserted to a master scFv framework sequence and the resulting single-CDR libraries are subjected to a round of proofread panning. The proofread CDR sequences are assembled to produce the final scFv library with six diversified CDRs.

Making It Work for Everyone: HTML5 and CSS Level 3 for Responsive, Accessible Design on Your Library's Web Site

ERIC Educational Resources Information Center

Baker, Stewart C.

2014-01-01

This article argues that accessibility and universality are essential to good Web design. A brief review of library science literature sets the issue of Web accessibility in context. The bulk of the article explains the design philosophies of progressive enhancement and responsive Web design, and summarizes recent updates to WCAG 2.0, HTML5, CSS…

The French Translation of the EAC DTD: A Few Thoughts on Interoperability with Reference to Authority Data

ERIC Educational Resources Information Center

Bourdon, Francoise

2005-01-01

The translation into French of the Encoded Archival Context (EAC) DTD tag library has been in progress for a few months. It is being carried out by a group of experts gathered by AFNOR, the French national standards agency. The main goal of this group is to foster the interoperability of authority data between archives, libraries and museums, and…

Bead-based screening in chemical biology and drug discovery.

PubMed

Komnatnyy, Vitaly V; Nielsen, Thomas E; Qvortrup, Katrine

2018-06-11

High-throughput screening is an important component of the drug discovery process. The screening of libraries containing hundreds of thousands of compounds requires assays amenable to miniaturisation and automization. Combinatorial chemistry holds a unique promise to deliver structurally diverse libraries for early drug discovery. Among the various library forms, the one-bead-one-compound (OBOC) library, where each bead carries many copies of a single compound, holds the greatest potential for the rapid identification of novel hits against emerging drug targets. However, this potential has not yet been fully realized due to a number of technical obstacles. In this feature article, we review the progress that has been made in bead-based library screening and its application to the discovery of bioactive compounds. We identify the key challenges of this approach and highlight key steps needed for making a greater impact in the field.

Development of a New 47-Group Library for the CASL Neutronics Simulators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Kang Seog; Williams, Mark L; Wiarda, Dorothea

The CASL core simulator MPACT is under development for the neutronics and thermal-hydraulics coupled simulation for the pressurized light water reactors. The key characteristics of the MPACT code include a subgroup method for resonance self-shielding, and a whole core solver with a 1D/2D synthesis method. The ORNL AMPX/SCALE code packages have been significantly improved to support various intermediate resonance self-shielding approximations such as the subgroup and embedded self-shielding methods. New 47-group AMPX and MPACT libraries based on ENDF/B-VII.0 have been generated for the CASL core simulator MPACT of which group structure comes from the HELIOS library. The new 47-group MPACTmore » library includes all nuclear data required for static and transient core simulations. This study discusses a detailed procedure to generate the 47-group AMPX and MPACT libraries and benchmark results for the VERA progression problems.« less

Library management in the tight budget seventies. Problems, challenges, and opportunities.

PubMed

White, H S

1977-01-01

This paper examines changes in the management of university, special, and medical libraries brought about by the budget curtailments that followed the more affluent funding period of the mid-1960s. Based on a study conducted for the National Science Foundation by the Indiana University Graduate Library School, this paper deals with misconceptions that have arisen in the relationship between publishers and librarians, and differentiates between the priority perceptions of academic and of special librarians in the allocation of progressively scarcer resources. It concludes that libraries must make strong efforts to reduce the growing erosion of materials acquisitions budgets because of growing labor costs as a percentage of all library expenditures; that they must make a working reality of the resource-sharing mechanisms established through consortia and networks; and that they must use advanced evaluative techniques in the determination of which services and programs to implement, expand, and retain, and which to curtail and abandon.

23 CFR 140.609 - Progress and final vouchers.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Progress and final vouchers. 140.609 Section 140.609 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES REIMBURSEMENT Reimbursement for Bond Issue Projects § 140.609 Progress and final vouchers. (a) Progress vouchers may be...

23 CFR 140.609 - Progress and final vouchers.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 23 Highways 1 2013-04-01 2013-04-01 false Progress and final vouchers. 140.609 Section 140.609 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES REIMBURSEMENT Reimbursement for Bond Issue Projects § 140.609 Progress and final vouchers. (a) Progress vouchers may be...

23 CFR 140.609 - Progress and final vouchers.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false Progress and final vouchers. 140.609 Section 140.609 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES REIMBURSEMENT Reimbursement for Bond Issue Projects § 140.609 Progress and final vouchers. (a) Progress vouchers may be...

23 CFR 140.609 - Progress and final vouchers.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Progress and final vouchers. 140.609 Section 140.609 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES REIMBURSEMENT Reimbursement for Bond Issue Projects § 140.609 Progress and final vouchers. (a) Progress vouchers may be...

Adiabatic quantum-flux-parametron cell library adopting minimalist design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Takeuchi, Naoki, E-mail: takeuchi-naoki-kx@ynu.jp; Yamanashi, Yuki; Yoshikawa, Nobuyuki

We herein build an adiabatic quantum-flux-parametron (AQFP) cell library adopting minimalist design and a symmetric layout. In the proposed minimalist design, every logic cell is designed by arraying four types of building block cells: buffer, NOT, constant, and branch cells. Therefore, minimalist design enables us to effectively build and customize an AQFP cell library. The symmetric layout reduces unwanted parasitic magnetic coupling and ensures a large mutual inductance in an output transformer, which enables very long wiring between logic cells. We design and fabricate several logic circuits using the minimal AQFP cell library so as to test logic cells inmore » the library. Moreover, we experimentally investigate the maximum wiring length between logic cells. Finally, we present an experimental demonstration of an 8-bit carry look-ahead adder designed using the minimal AQFP cell library and demonstrate that the proposed cell library is sufficiently robust to realize large-scale digital circuits.« less

Adiabatic quantum-flux-parametron cell library adopting minimalist design

NASA Astrophysics Data System (ADS)

Takeuchi, Naoki; Yamanashi, Yuki; Yoshikawa, Nobuyuki

2015-05-01

We herein build an adiabatic quantum-flux-parametron (AQFP) cell library adopting minimalist design and a symmetric layout. In the proposed minimalist design, every logic cell is designed by arraying four types of building block cells: buffer, NOT, constant, and branch cells. Therefore, minimalist design enables us to effectively build and customize an AQFP cell library. The symmetric layout reduces unwanted parasitic magnetic coupling and ensures a large mutual inductance in an output transformer, which enables very long wiring between logic cells. We design and fabricate several logic circuits using the minimal AQFP cell library so as to test logic cells in the library. Moreover, we experimentally investigate the maximum wiring length between logic cells. Finally, we present an experimental demonstration of an 8-bit carry look-ahead adder designed using the minimal AQFP cell library and demonstrate that the proposed cell library is sufficiently robust to realize large-scale digital circuits.

Information Resources Management Skills for Academic Librarians: Final Report.

ERIC Educational Resources Information Center

McClure, Charles R.; And Others

This report summarizes activities conducted from fall 1984 through spring 1985, under a planning grant from the Council on Library Resources for Innovation and Improvement of Basic and Supplementary Education for Academic and Research Libraries. The report includes a review of selected literature related to educational programs for academic…

The Impact of Automation on Libraries. Final Report.

ERIC Educational Resources Information Center

Cline, Hugh F.; Sinnott, Loraine T.

This project examined a series of alternative policies for the management and funding of university libraries as they adopt and adapt to various information science technologies to accomplish the functions of acquisitions, cataloging, circulation, and reference services. Comparative case studies were completed at the University of Chicago,…

75 FR 47464 - Exemption to Prohibition on Circumvention of Copyright Protection Systems for Access Control...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-06

... LIBRARY OF CONGRESS Copyright Office 37 CFR Part 201 [Docket No. RM 2008-8] Exemption to Prohibition on Circumvention of Copyright Protection Systems for Access Control Technologies AGENCY: Copyright Office, Library of Congress. ACTION: Final Rule; correction. SUMMARY: The Copyright Office makes a...

New Directions in Library and Information Science Education. Final Report. Volume 2.1: Academic Librarian Competencies.

ERIC Educational Resources Information Center

Griffiths, Jose-Marie; And Others

This document contains validated activities and competencies needed by librarians working in an academic library. The activities and competencies are organized according to the functions which academic librarians perform: acquisitions; cataloging; circulation and reader services; collection maintenance; interlibrary loan; management; reference;…

New Directions in Library and Information Science Education. Final Report. Volume 2.4: Special Librarian Competencies.

ERIC Educational Resources Information Center

Griffiths, Jose-Marie; And Others

This document contains validated activities and competencies needed by librarians working in a special library. The activities and competencies are organized according to the functions which special librarians perform: acquisitions; cataloging; circulation and user services; collection maintenance; interlibrary loan; management; reference; and…

New Directions in Library and Information Science Education. Final Report. Volume 2.2: Public Librarian Competencies.

ERIC Educational Resources Information Center

Griffiths, Jose-Marie; And Others

This document contains validated activities and competencies needed by librarians working in a public library. The activities and competencies are organized according to the functions which public librarians perform: acquisitions; cataloging; circulation and reader services; collection maintenance; interlibrary loan; management; reference; and…

New Directions in Library and Information Science Education. Final Report. Volume 2.3: School Librarian Competencies.

ERIC Educational Resources Information Center

Griffiths, Jose-Marie; And Others

This document contains validated activities and competencies needed by librarians working in a school library. The activities and competencies are organized according to the functions which school librarians perform: acquisitions; cataloging; circulation and reader services; collection maintenance; interlibrary loan; management; reference; and…

78 FR 66276 - Determination of Rates and Terms for Business Establishment Services

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-05

... LIBRARY OF CONGRESS Copyright Royalty Board 37 CFR Part 384 [Docket No. 2012-1 CRB Business... Board, Library of Congress. ACTION: Final rule. SUMMARY: The Copyright Royalty Judges are publishing... . SUPPLEMENTARY INFORMATION: In 1995, Congress enacted the Digital Performance in Sound Recordings Act, Public Law...

75 FR 5513 - Determination of Rates and Terms for Preexisting Subscription Services and Satellite Digital...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-03

... LIBRARY OF CONGRESS Copyright Royalty Board 37 CFR Part 382 [Docket No. 2006-1 CRB DSTRA] Determination of Rates and Terms for Preexisting Subscription Services and Satellite Digital Audio Radio Services AGENCY: Copyright Royalty Board, Library of Congress. ACTION: Final rule. SUMMARY: The Copyright...

78 FR 78309 - Mechanical and Digital Phonorecord Delivery Compulsory License

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-26

... Rates for Mechanical and Digital Phonorecord. Final rule. 78 FR 67938, Nov. 13, 2013. The Office finds... LIBRARY OF CONGRESS U.S. Copyright Office 37 CFR Parts 201 and 210 [Docket No. 2012-7] Mechanical and Digital Phonorecord Delivery Compulsory License AGENCY: U.S. Copyright Office, Library of Congress...

UCLA Working Group on Public Catalogs. Final Report.

ERIC Educational Resources Information Center

Aroeste, Jean; And Others

Though recent technological developments have promised solutions to the costly problems of expanding card catalogs and changing cataloging practices, at the University of California libraries the problems have been compounded by a desire to stay compatible with the changing conventions of the Library of Congress and by an increasingly stringent…

Vitamin D Levels Predict Multiple Sclerosis Progression

MedlinePlus

... Record Research & Training Medical Research Initiatives Science Highlights Science Education Research in NIH Labs & Clinics Training Opportunities Library Resources Research Resources Clinical Research Resources Safety, Regulation ...

Human Resources in the Library System. Course 2, Leader's Handbook, Part 2: Aids (Volume 1). Final Report, Phase 2, Post-Master's Education for Middle and Upper-Level Personnel in Libraries and Information Centers.

ERIC Educational Resources Information Center

Goodman, Charles H.; Stone, Elizabeth W.

The aids to be used in a course designed for the continuing education of professional librarians on human resources in the library have been compiled in two volumes. The first of these contains forms, work assignments, handouts, and transparencies. Forms are for personal information, work assignments, evaluations, and critiques. Work assignments…

Quantitation of next generation sequencing library preparation protocol efficiencies using droplet digital PCR assays - a systematic comparison of DNA library preparation kits for Illumina sequencing.

PubMed

Aigrain, Louise; Gu, Yong; Quail, Michael A

2016-06-13

The emergence of next-generation sequencing (NGS) technologies in the past decade has allowed the democratization of DNA sequencing both in terms of price per sequenced bases and ease to produce DNA libraries. When it comes to preparing DNA sequencing libraries for Illumina, the current market leader, a plethora of kits are available and it can be difficult for the users to determine which kit is the most appropriate and efficient for their applications; the main concerns being not only cost but also minimal bias, yield and time efficiency. We compared 9 commercially available library preparation kits in a systematic manner using the same DNA sample by probing the amount of DNA remaining after each protocol steps using a new droplet digital PCR (ddPCR) assay. This method allows the precise quantification of fragments bearing either adaptors or P5/P7 sequences on both ends just after ligation or PCR enrichment. We also investigated the potential influence of DNA input and DNA fragment size on the final library preparation efficiency. The overall library preparations efficiencies of the libraries show important variations between the different kits with the ones combining several steps into a single one exhibiting some final yields 4 to 7 times higher than the other kits. Detailed ddPCR data also reveal that the adaptor ligation yield itself varies by more than a factor of 10 between kits, certain ligation efficiencies being so low that it could impair the original library complexity and impoverish the sequencing results. When a PCR enrichment step is necessary, lower adaptor-ligated DNA inputs leads to greater amplification yields, hiding the latent disparity between kits. We describe a ddPCR assay that allows us to probe the efficiency of the most critical step in the library preparation, ligation, and to draw conclusion on which kits is more likely to preserve the sample heterogeneity and reduce the need of amplification.

10. copy of a construction progress photograph taken by the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. copy of a construction progress photograph taken by the Hunkin-Conkey Construction Company, dated October 25, 1916. Photo shows the reinforced concrete subway deck as it appeared shortly after construction. A portion of arch number 12, can be see. Photo courtesy of Cleveland Public Library. - Detroit Superior High Level Bridge, Cleveland, Cuyahoga County, OH

Evaluating Chagas disease progression and cure through blood-derived biomarkers: a systematic review.

PubMed

Requena-Méndez, Ana; López, Manuel Carlos; Angheben, Andrea; Izquierdo, Luis; Ribeiro, Isabela; Pinazo, Maria-Jesús; Gascon, Joaquim; Muñoz, José

2013-09-01

This article reviews the usefulness of various types of blood-derived biomarkers that are currently being studied to predict the progression of Chagas disease in patients with the indeterminate form, to assess the efficacy of antiparasitic drugs and to identify early cardiac and gastrointestinal damage. The authors used a search strategy based on MEDLINE, Cochrane Library Register for systematic review, EmBase, Global Health and LILACS databases. Out of 1716 screened articles, only 166 articles were eligible for final inclusion. The authors classified the biomarkers according to their biochemical structure and primary biological activity in four groups: i) markers of inflammation and cellular injury, ii) metabolic biomakers, iii) prothrombotic biomarkers and iv) markers derived from specific antigens of the parasite. Several potential biomarkers might have clinical potential for the detection of early cardiopathy. Such capacity is imperative in order to detect high-risk patients who require intensive monitoring and earlier therapy. Prospective studies with longer follow-ups are needed for the appraisal of biomarkers assessing clinical or microbiological cure after therapy. At the same time, studies evaluating more than one biomarker are useful to compare the efficacy among them given the lack of a recognized gold standard.

77 FR 16558 - General Management Plan/Final Environmental Impact Statement, Hampton National Historic Site...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-21

... Management Plan/Final Environmental Impact Statement, Hampton National Historic Site, Maryland AGENCY...) announces the availability of the Final Environmental Impact Statement for the General Management Plan.../Baltimore County Library, 320 York Avenue, Towson, Maryland 21204. Baltimore County Tourism Office and...

[Primary culture of cat intestinal epithelial cell and construction of its cDNA library].

PubMed

Ye, L; Gui-Hua, Z; Kun, Y; Hong-Fa, W; Ting, X; Gong-Zhen, L; Wei-Xia, Z; Yong, C

2017-04-12

Objective To establish the primary cat intestinal epithelial cells (IECs) culture methods and construct the cDNA library for the following yeast two-hybrid experiment, so as to screen the virulence interaction factors among the final host. Methods The primary cat IECs were cultured by the tissue cultivation and combined digestion with collagenase XI and dispase I separately. Then the cat IECs cultured was identified with the morphological observation and cyto-keratin detection, by using goat anti-cyto-keratin monoclonal antibodies. The mRNA of cat IECs was isolated and used as the template to synthesize the first strand cDNA by SMART™ technology, and then the double-strand cDNAs were acquired by LD-PCR, which were subsequently cloned into the plasmid PGADT7-Rec to construct yeast two-hybrid cDNA library in the yeast strain Y187 by homologous recombination. Matchmaker™ Insert Check PCR was used to detect the size distribution of cDNA fragments after the capacity calculation of the cDNA library. Results The comparison of the two cultivation methods indicated that the combined digestion of collagenase XI and dispase I was more effective than the tissue cultivation. The cat IECs system of continuous culture was established and the cat IECs with high purity were harvested for constructing the yeast two-hybrid cDNA library. The library contained 1.1×10 6 independent clones. The titer was 2.8×10 9 cfu/ml. The size of inserted fragments was among 0.5-2.0 kb. Conclusion The yeast two-hybrid cDNA library of cat IECs meets the requirements of further screen research, and this study lays the foundation of screening the Toxoplasma gondii virulence interaction factors among the cDNA libraries of its final hosts.

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The Library Services Alliance is a unique multi-type library consortium committed to resource sharing. As a voluntary association of university and governmental laboratory libraries supporting scientific research, the Alliance has become a leader in New Mexico in using cooperative ventures to cost-effectively expand resources supporting their scientific and technical communities. During 1994, the alliance continued to expand on their strategic planning foundation to enhance access to research information for the scientific and technical communities. Significant progress was made in facilitating easy access to the on-line catalogs of member libraries via connections through the Internet. Access to Alliance resources is nowmore » available via the World Wide Web and Gopher, as well as links to other databases and electronic information. This report highlights the accomplishments of the Alliance during calendar year 1994.« less

Availability of a library of infrared (2.1-25.0 μm) mineral spectra

USGS Publications Warehouse

Salisbury, John W.; Walter, Louis S.; Vergo, Norma

1989-01-01

All previously published libraries of infrared mineral spectra are in the form of transmittance.  Reflectance spectra are, however, more useful for remote sensing and some potential laboratory applications, such as the use of an infrared microscope for mineral identification on polished sections. This note points out that construction of a new library of infrared (2.1-25.0 μm) mineral spectra is in progress. Both transmittance and reflectance measurements of a selection of 63 different, well-characteized minerals have been published to date. These data are available in both hard copy and digital form.

Investigation of the Public Library as a Linking Agent to Major Scientific, Educational, Social, and Environmental Data Bases. Sixth Progress Report, January 1976-March 1976.

ERIC Educational Resources Information Center

Summit, Roger K.; Firschein, Oscar

In conjunction with the National Science Foundation (NSD), an on-going experiment is being conducted to test the feasibility of increasing public access to 16 major data bases by providing public libraries with on-line, interactive, retrieval capacity. During the period from January to March 1976, the major activities of the study were: (1) a…

The Use of General Collections at the University of California: A Study of Unrecorded Use, At-the-Shelf Discovery, and Immediacy of Need for Materials at the Davis and Santa Cruz Campus Libraries. Final Report. Research Report RR-80-1.

ERIC Educational Resources Information Center

Lawrence, Gary S.; Oja, Anne R.

Use studies were conducted at the main libraries and science branches at the Davis and Santa Cruz campuses of the University of California to gather data for use in the detailed planning for establishing regional compact shelving facilities for infrequently circulated library material. Analysis of preliminary data on the three areas…

Combinatorial Algorithms to Enable Computational Science and Engineering: Work from the CSCAPES Institute

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boman, Erik G.; Catalyurek, Umit V.; Chevalier, Cedric

2015-01-16

This final progress report summarizes the work accomplished at the Combinatorial Scientific Computing and Petascale Simulations Institute. We developed Zoltan, a parallel mesh partitioning library that made use of accurate hypergraph models to provide load balancing in mesh-based computations. We developed several graph coloring algorithms for computing Jacobian and Hessian matrices and organized them into a software package called ColPack. We developed parallel algorithms for graph coloring and graph matching problems, and also designed multi-scale graph algorithms. Three PhD students graduated, six more are continuing their PhD studies, and four postdoctoral scholars were advised. Six of these students and Fellowsmore » have joined DOE Labs (Sandia, Berkeley), as staff scientists or as postdoctoral scientists. We also organized the SIAM Workshop on Combinatorial Scientific Computing (CSC) in 2007, 2009, and 2011 to continue to foster the CSC community.« less

Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis

PubMed Central

Patten, Shunmoogum A.; Aggad, Dina; Martinez, Jose; Tremblay, Elsa; Petrillo, Janet; Armstrong, Gary A.B.; Maios, Claudia; Liao, Meijiang; Ciura, Sorana; Wen, Xiao-Yan; Rafuse, Victor; Ichida, Justin; Zinman, Lorne; Julien, Jean-Pierre; Kabashi, Edor; Robitaille, Richard; Korngut, Lawrence; Parker, J. Alexander

2017-01-01

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing, fatal disorder with no effective treatment. We used simple genetic models of ALS to screen phenotypically for potential therapeutic compounds. We screened libraries of compounds in C. elegans, validated hits in zebrafish, and tested the most potent molecule in mice and in a small clinical trial. We identified a class of neuroleptics that restored motility in C. elegans and in zebrafish, and the most potent was pimozide, which blocked T-type Ca2+ channels in these simple models and stabilized neuromuscular transmission in zebrafish and enhanced it in mice. Finally, a short randomized controlled trial of sporadic ALS subjects demonstrated stabilization of motility and evidence of target engagement at the neuromuscular junction. Simple genetic models are, thus, useful in identifying promising compounds for the treatment of ALS, such as neuroleptics, which may stabilize neuromuscular transmission and prolong survival in this disease. PMID:29202456

An Optimizing Compiler for Petascale I/O on Leadership-Class Architectures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kandemir, Mahmut Taylan; Choudary, Alok; Thakur, Rajeev

In high-performance computing (HPC), parallel I/O architectures usually have very complex hierarchies with multiple layers that collectively constitute an I/O stack, including high-level I/O libraries such as PnetCDF and HDF5, I/O middleware such as MPI-IO, and parallel file systems such as PVFS and Lustre. Our DOE project explored automated instrumentation and compiler support for I/O intensive applications. Our project made significant progress towards understanding the complex I/O hierarchies of high-performance storage systems (including storage caches, HDDs, and SSDs), and designing and implementing state-of-the-art compiler/runtime system technology that targets I/O intensive HPC applications that target leadership class machine. This final reportmore » summarizes the major achievements of the project and also points out promising future directions Two new sections in this report compared to the previous report are IOGenie and SSD/NVM-specific optimizations.« less

Chemical synthesis, NMR analysis and evaluation on a cancer xenograft model (HL-60) of the aminosteroid derivative RM-133.

PubMed

Maltais, René; Hospital, Audrey; Delhomme, Audrey; Roy, Jenny; Poirier, Donald

2014-04-01

The aminosteroid derivative RM-133 has been reported to be a promising pro-apoptotic agent showing activity on various cancer cell lines. Following the development of solid-phase synthesis that generated a series of libraries of aminosteroid derivatives, we now report the development of a convenient liquid phase chemical synthesis of RM-133, the most promising candidate, in order to obtain sufficient quantities to proceed with the first preclinical assays. A simple and convergent six-step synthesis was designed and allowed the preparation of a gram-quantity scale of RM-133. This aminosteroid derivative was also fully characterized by NMR experiments which revealed an interesting mixture of conformers. Finally, the in vivo potency of RM-133 was evaluated on a xenograft model in nude mice with HL-60 tumors, which has resulted in the blocking of tumor progression by 57%. Copyright © 2014 Elsevier Inc. All rights reserved.

Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis.

PubMed

Patten, Shunmoogum A; Aggad, Dina; Martinez, Jose; Tremblay, Elsa; Petrillo, Janet; Armstrong, Gary Ab; La Fontaine, Alexandre; Maios, Claudia; Liao, Meijiang; Ciura, Sorana; Wen, Xiao-Yan; Rafuse, Victor; Ichida, Justin; Zinman, Lorne; Julien, Jean-Pierre; Kabashi, Edor; Robitaille, Richard; Korngut, Lawrence; Parker, J Alexander; Drapeau, Pierre

2017-11-16

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing, fatal disorder with no effective treatment. We used simple genetic models of ALS to screen phenotypically for potential therapeutic compounds. We screened libraries of compounds in C. elegans, validated hits in zebrafish, and tested the most potent molecule in mice and in a small clinical trial. We identified a class of neuroleptics that restored motility in C. elegans and in zebrafish, and the most potent was pimozide, which blocked T-type Ca2+ channels in these simple models and stabilized neuromuscular transmission in zebrafish and enhanced it in mice. Finally, a short randomized controlled trial of sporadic ALS subjects demonstrated stabilization of motility and evidence of target engagement at the neuromuscular junction. Simple genetic models are, thus, useful in identifying promising compounds for the treatment of ALS, such as neuroleptics, which may stabilize neuromuscular transmission and prolong survival in this disease.

Copyright Policy and Practice in Electronic Reserves among ARL Libraries

ERIC Educational Resources Information Center

Hansen, David R.; Cross, William M.; Edwards, Phillip M.

2013-01-01

This paper presents the results of a survey of 110 ARL institutions regarding their copyright policies for providing electronic reserves. It compiles descriptive statistics on library practice as well as coding responses to reveal trends and shared practices. Finally, it presents conclusions about policy making, decision making and risk aversion…

77 FR 46516 - Notice of Availability of the Final Environmental Impact Statement, Including a Programmatic...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-03

... Groundwater Development Project, Nevada AGENCY: Bureau of Land Management, Interior. ACTION: Notice of... White Pine Counties Groundwater Development Project (SNWA Project), and by this notice is announcing the... Drive, Las Vegas Libraries in Nevada: Nevada State Library, 100 N. Stewart St., Carson City White Pine...

76 FR 5196 - Aransas National Wildlife Refuge Complex, Aransas, Calhoun, and Refugio Counties, TX; Final...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-28

... recreational development, the protection of natural resources, and the conservation of endangered or threatened.... We completed a thorough analysis of impacts on the human environment, which we included in the EA.../STRC/laguna/Index_Laguna.html . At the following libraries: Library Address Phone number Victoria...

Demonstration of Cataloging Support Services and Marc II Conversion. Final Report.

ERIC Educational Resources Information Center

Buckland, Lawrence F.; And Others

Beginning in December, 1967, the New England Library Information Network (NELINET) was demonstrated in actual operation using Machine-Readable Cataloging (MARC I) bibliographic data. Section 1 of this report is an introduction and summary of the project. Section 2 described the library processing function demonstrated which included catalog card…

Assessing Information on the Internet: Toward Providing Library Services for Computer-Mediated Communication. A Final Report.

ERIC Educational Resources Information Center

Dillon, Martin; And Others

The Online Computer Library Center Internet Resource project focused on the nature of electronic textual information available through remote access using the Internet and the problems associated with creating machine-readable cataloging (MARC) records for these objects using current USMARC format for computer files and "Anglo-American…

78 FR 71501 - Cost of Living Adjustment for Performance of Musical Compositions by Colleges and Universities

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-29

... LIBRARY OF CONGRESS Copyright Royalty Board 37 CFR Part 381 [Docket No. 2013-9 CRB NCEB COLA] Cost of Living Adjustment for Performance of Musical Compositions by Colleges and Universities AGENCY: Copyright Royalty Board, Library of Congress. ACTION: Final rule. SUMMARY: The Copyright Royalty Judges...

75 FR 74623 - Cost of Living Adjustment for Performance of Musical Compositions by Colleges and Universities

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-01

... LIBRARY OF CONGRESS Copyright Royalty Board 37 CFR Part 381 [Docket No. 2010-9 CRB] Cost of Living Adjustment for Performance of Musical Compositions by Colleges and Universities AGENCY: Copyright Royalty Board, Library of Congress. ACTION: Final rule. SUMMARY: The Copyright Royalty Judges announce a cost of...

76 FR 74703 - Cost of Living Adjustment for Performance of Musical Compositions by Colleges and Universities

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-01

... LIBRARY OF CONGRESS Copyright Royalty Board 37 CFR Part 381 [Docket No. 2011-9 CRB NCEB COLA] Cost of Living Adjustment for Performance of Musical Compositions by Colleges and Universities AGENCY: Copyright Royalty Board, Library of Congress. ACTION: Final rule. SUMMARY: The Copyright Royalty Judges...

Adult Services in the Eighties: Final Report.

ERIC Educational Resources Information Center

Heim, Kathleen M.

The American Library Association's (ALA) Adult Services in the Eighties (ASE) project was undertaken to supply information about areas of current and unique concentration to aid librarians in identifying, describing, and planning the scope of adult services in their own libraries. The ASE project updates a study conducted in 1954--the most recent…

75 FR 14074 - Digital Performance Right in Sound Recordings and Ephemeral Recordings for a New Subscription...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-24

... LIBRARY OF CONGRESS Copyright Royalty Board 37 CFR Part 383 [Docket No. 2009-2 CRB New Subscription II] Digital Performance Right in Sound Recordings and Ephemeral Recordings for a New Subscription Service AGENCY: Copyright Royalty Board, Library of Congress. ACTION: Final rule. SUMMARY: The Copyright...

76 FR 45695 - Notice and Recordkeeping for Use of Sound Recordings Under Statutory License

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-01

... LIBRARY OF CONGRESS Copyright Royalty Board 37 CFR Parts 370 and 382 [Docket No. RM 2011-5] Notice..., Library of Congress. ACTION: Final rule. SUMMARY: The Copyright Royalty Judges are amending their... of digital audio transmissions pursuant to statutory license. Proxy reports of use will be used for...

Evaluation of Three MALDI-TOF Mass Spectrometry Libraries for the Identification of Filamentous Fungi in Three Clinical Microbiology Laboratories in Manitoba, Canada.

PubMed

Stein, Markus; Tran, Vanessa; Nichol, Kimberly A; Lagacé-Wiens, Philippe; Pieroni, Peter; Adam, Heather J; Turenne, Christine; Walkty, Andrew J; Normand, Anne-Cécile; Hendrickx, Marijke; Piarroux, Renaud; Karlowsky, James A

2018-06-12

Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) is commonly used by clinical microbiology laboratories to identify bacterial pathogens and yeasts, but not for the identification of moulds. Recent progress in extraction protocols and the composition of comparative libraries support potential application of MALDI-TOF MS for mould identification in clinical microbiology laboratories. We evaluated the performance of the Bruker Microflex ™ MALDI-TOF MS instrument (Billerica, MA, USA) to identify clinical isolates and reference strains of moulds using three libraries, the Bruker mould library, the National Institutes of Health (NIH) library, and the Mass Spectrometry Identification (MSI) online library, and compared those results to conventional (morphological) and molecular (18S/ITS; gold standard) identification methods. All three libraries demonstrated greater accuracy in genus identification (≥94.9%) than conventional methods (86.4%). MALDI-TOF MS identified 73.3% of isolates to species-level compared to only 31.7% by conventional methods. The MSI library demonstrated the highest rate of species-level identification (72.0%) compared to NIH (19.5%) and Bruker (13.6%) libraries. Greater than 20% of moulds remained unidentified to species-level by all three MALDI-TOF MS libraries primarily because of library limitations or imperfect spectra. The overall identification rate of each MALDI-TOF MS library depended on the number of species and the number of spectra representing each species in the library. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Automated synthesis of a 96 product-sized library of triazole derivatives using a solid phase supported copper catalyst.

PubMed

Jlalia, Ibtissem; Beauvineau, Claire; Beauvière, Sophie; Onen, Esra; Aufort, Marie; Beauvineau, Aymeric; Khaba, Eihab; Herscovici, Jean; Meganem, Faouzi; Girard, Christian

2010-04-28

This article deal with the parallel synthesis of a 96 product-sized library using a polymer-based copper catalyst that we developed which can be easily separated from the products by simple filtration. This gave us the opportunity to use this catalyst in an automated chemical synthesis station (Chemspeed ASW-2000). Studies and results about the preparation of the catalyst, its use in different solvent systems, its recycling capabilities and its scope and limitations in the synthesis of this library will be addressed. The synthesis of the triazole library and the very good results obtained will finally be discussed.

Rethinking the core list of journals for libraries that serve schools and colleges of pharmacy.

PubMed

Beckett, Robert D; Cole, Sabrina W; Rogers, Hannah K; Bickett, Skye; Seeger, Christina; McDaniel, Jennifer A

2014-10-01

The Core List of Journals for Libraries that Serve Schools and Colleges of Pharmacy is a guide for developing and maintaining pharmacy-affiliated library collections. A work group was created to update the list and design a process for updating that will streamline future revisions. Work group members searched the National Library of Medicine catalog for an initial list of journals and then applied inclusion criteria to narrow the list. The work group finalized the fifth edition of the list with 225 diverse publications and produced a sustainable set of criteria for journal inclusion, providing a structured, objective process for future updates.

Rethinking the Core List of Journals for Libraries that Serve Schools and Colleges of Pharmacy

PubMed Central

Beckett, Robert D.; Rogers, Hannah K.; Bickett, Skye; Seeger, Christina; McDaniel, Jennifer A.

2014-01-01

The Core List of Journals for Libraries that Serve Schools and Colleges of Pharmacy is a guide for developing and maintaining pharmacy-affiliated library collections. A work group was created to update the list and design a process for updating that will streamline future revisions. Work group members searched the National Library of Medicine catalog for an initial list of journals and then applied inclusion criteria to narrow the list. The work group finalized the fifth edition of the list with 225 diverse publications and produced a sustainable set of criteria for journal inclusion, providing a structured, objective process for future updates. PMID:25349548

Metrology of deep trench etched memory structures using 3D scatterometry

NASA Astrophysics Data System (ADS)

Reinig, Peter; Dost, Rene; Moert, Manfred; Hingst, Thomas; Mantz, Ulrich; Moffitt, Jasen; Shakya, Sushil; Raymond, Christopher J.; Littau, Mike

2005-05-01

Scatterometry is receiving considerable attention as an emerging optical metrology in the silicon industry. One area of progress in deploying these powerful measurements in process control is performing measurements on real device structures, as opposed to limiting scatterometry measurements to periodic structures, such as line-space gratings, placed in the wafer scribe. In this work we will discuss applications of 3D scatterometry to the measurement of advanced trench memory devices. This is a challenging and complex scatterometry application that requires exceptionally high-performance computational abilities. In order to represent the physical device, the relatively tall structures require a high number of slices in the rigorous coupled wave analysis (RCWA) theoretical model. This is complicated further by the presence of an amorphous silicon hard mask on the surface, which is highly sensitive to reflectance scattering and therefore needs to be modeled in detail. The overall structure is comprised of several layers, with the trenches presenting a complex bow-shape sidewall that must be measured. Finally, the double periodicity in the structures demands significantly greater computational capabilities. Our results demonstrate that angular scatterometry is sensitive to the key parameters of interest. The influence of further model parameters and parameter cross correlations have to be carefully taken into account. Profile results obtained by non-library optimization methods compare favorably with cross-section SEM images. Generating a model library suitable for process control, which is preferred for precision, presents numerical throughput challenges. Details will be discussed regarding library generation approaches and strategies for reducing the numerical overhead. Scatterometry and SEM results will be compared, leading to conclusions about the feasibility of this advanced application.

MT71x: Multi-Temperature Library Based on ENDF/B-VII.1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Conlin, Jeremy Lloyd; Parsons, Donald Kent; Gray, Mark Girard

The Nuclear Data Team has released a multitemperature transport library, MT71x, based upon ENDF/B-VII.1 with a few modifications as well as additional evaluations for a total of 427 isotope tables. The library was processed using NJOY2012.39 into 23 temperatures. MT71x consists of two sub-libraries; MT71xMG for multigroup energy representation data and MT71xCE for continuous energy representation data. These sub-libraries are suitable for deterministic transport and Monte Carlo transport applications, respectively. The SZAs used are the same for the two sub-libraries; that is, the same SZA can be used for both libraries. This makes comparisons between the two libraries and betweenmore » deterministic and Monte Carlo codes straightforward. Both the multigroup energy and continuous energy libraries were verified and validated with our checking codes checkmg and checkace (multigroup and continuous energy, respectively) Then an expanded suite of tests was used for additional verification and, finally, verified using an extensive suite of critical benchmark models. We feel that this library is suitable for all calculations and is particularly useful for calculations sensitive to temperature effects.« less

Peregrine

PubMed Central

Langevin, Stanley A.; Bent, Zachary W.; Solberg, Owen D.; Curtis, Deanna J.; Lane, Pamela D.; Williams, Kelly P.; Schoeniger, Joseph S.; Sinha, Anupama; Lane, Todd W.; Branda, Steven S.

2013-01-01

Use of second generation sequencing (SGS) technologies for transcriptional profiling (RNA-Seq) has revolutionized transcriptomics, enabling measurement of RNA abundances with unprecedented specificity and sensitivity and the discovery of novel RNA species. Preparation of RNA-Seq libraries requires conversion of the RNA starting material into cDNA flanked by platform-specific adaptor sequences. Each of the published methods and commercial kits currently available for RNA-Seq library preparation suffers from at least one major drawback, including long processing times, large starting material requirements, uneven coverage, loss of strand information and high cost. We report the development of a new RNA-Seq library preparation technique that produces representative, strand-specific RNA-Seq libraries from small amounts of starting material in a fast, simple and cost-effective manner. Additionally, we have developed a new quantitative PCR-based assay for precisely determining the number of PCR cycles to perform for optimal enrichment of the final library, a key step in all SGS library preparation workflows. PMID:23558773

Composing compound libraries for hit discovery--rationality-driven preselection or random choice by structural diversity?

PubMed

Weidel, Elisabeth; Negri, Matthias; Empting, Martin; Hinsberger, Stefan; Hartmann, Rolf W

2014-01-01

In order to identify new scaffolds for drug discovery, surface plasmon resonance is frequently used to screen structurally diverse libraries. Usually, hit rates are low and identification processes are time consuming. Hence, approaches which improve hit rates and, thus, reduce the library size are required. In this work, we studied three often used strategies for their applicability to identify inhibitors of PqsD. In two of them, target-specific aspects like inhibition of a homologous protein or predicted binding determined by virtual screening were used for compound preselection. Finally, a fragment library, covering a large chemical space, was screened and served as comparison. Indeed, higher hit rates were observed for methods employing preselected libraries indicating that target-oriented compound selection provides a time-effective alternative.

Model-based reconstruction of synthetic promoter library in Corynebacterium glutamicum.

PubMed

Zhang, Shuanghong; Liu, Dingyu; Mao, Zhitao; Mao, Yufeng; Ma, Hongwu; Chen, Tao; Zhao, Xueming; Wang, Zhiwen

2018-05-01

To develop an efficient synthetic promoter library for fine-tuned expression of target genes in Corynebacterium glutamicum. A synthetic promoter library for C. glutamicum was developed based on conserved sequences of the - 10 and - 35 regions. The synthetic promoter library covered a wide range of strengths, ranging from 1 to 193% of the tac promoter. 68 promoters were selected and sequenced for correlation analysis between promoter sequence and strength with a statistical model. A new promoter library was further reconstructed with improved promoter strength and coverage based on the results of correlation analysis. Tandem promoter P70 was finally constructed with increased strength by 121% over the tac promoter. The promoter library developed in this study showed a great potential for applications in metabolic engineering and synthetic biology for the optimization of metabolic networks. To the best of our knowledge, this is the first reconstruction of synthetic promoter library based on statistical analysis of C. glutamicum.

Peregrine: A rapid and unbiased method to produce strand-specific RNA-Seq libraries from small quantities of starting material.

PubMed

Langevin, Stanley A; Bent, Zachary W; Solberg, Owen D; Curtis, Deanna J; Lane, Pamela D; Williams, Kelly P; Schoeniger, Joseph S; Sinha, Anupama; Lane, Todd W; Branda, Steven S

2013-04-01

Use of second generation sequencing (SGS) technologies for transcriptional profiling (RNA-Seq) has revolutionized transcriptomics, enabling measurement of RNA abundances with unprecedented specificity and sensitivity and the discovery of novel RNA species. Preparation of RNA-Seq libraries requires conversion of the RNA starting material into cDNA flanked by platform-specific adaptor sequences. Each of the published methods and commercial kits currently available for RNA-Seq library preparation suffers from at least one major drawback, including long processing times, large starting material requirements, uneven coverage, loss of strand information and high cost. We report the development of a new RNA-Seq library preparation technique that produces representative, strand-specific RNA-Seq libraries from small amounts of starting material in a fast, simple and cost-effective manner. Additionally, we have developed a new quantitative PCR-based assay for precisely determining the number of PCR cycles to perform for optimal enrichment of the final library, a key step in all SGS library preparation workflows.

Library management in the tight budget seventies. Problems, challenges, and opportunities.

PubMed Central

White, H S

1977-01-01

This paper examines changes in the management of university, special, and medical libraries brought about by the budget curtailments that followed the more affluent funding period of the mid-1960s. Based on a study conducted for the National Science Foundation by the Indiana University Graduate Library School, this paper deals with misconceptions that have arisen in the relationship between publishers and librarians, and differentiates between the priority perceptions of academic and of special librarians in the allocation of progressively scarcer resources. It concludes that libraries must make strong efforts to reduce the growing erosion of materials acquisitions budgets because of growing labor costs as a percentage of all library expenditures; that they must make a working reality of the resource-sharing mechanisms established through consortia and networks; and that they must use advanced evaluative techniques in the determination of which services and programs to implement, expand, and retain, and which to curtail and abandon. PMID:831887

We Spent Our Summer Chasing Unicorns: A Young Adult Reading Game Update.

ERIC Educational Resources Information Center

Edgerton, Cathi

1986-01-01

Describes a young adult summer reading game which is offered in three age-level versions from grades 1 through 12 at Enoch Pratt Free Library (Maryland). Benefits of young adult reading games in public libraries, game rules and sample questions, and the game finale visit to Walters Art Gallery are highlighted. (EJS)

High School to University: What Skills Do Students Need?

ERIC Educational Resources Information Center

Daniel, Eileen

The problem of transferring library and information searching skills from high school to college is not new, but has become intensified in the last decade by the pressures of the information explosion, new technologies, and budget reductions. This paper compares the library skills required of students in their final year of high school with those…

Australian Information Education in the 21st Century--The Synergy among Research, Teaching and Practice

ERIC Educational Resources Information Center

Nastasie, Daniela L.

2012-01-01

In 2011 a group of Australian Library and Information Science academics led by Prof. Helen Partridge conducted an investigation into the Australian Library and Information Science education in the 21st century. The project was funded by the Australian Learning and Teaching Council (ALTC) and the final report, titled "Re-conceptualising and…

The Cost of Maintaining and Updating Library Card Catalogs. Final Report.

ERIC Educational Resources Information Center

Dolby, J. L.; And Others

The main problem considered in this project is whether it will be possible for civilization to cope with the increasing quantities of archival information that must be stored in libraries, and if so, whether traditional methods of identification and access will prove adequate to the task. It is concluded that unless the storage, transmission, and…

An Evaluation of the Utility and Cost of Computerized Library Catalogs. Final Report.

ERIC Educational Resources Information Center

Dolby, J.L.; And Others

This study analyzes the basic cost factors in the automation of library catalogs, with a separate examination of the influence of typography on the cost of printed catalogs and the use of efficient automatic error detection procedures in processing bibliographic records. The utility of automated catalogs is also studied, based on data from a…

Preservation at Stony Brook. Preservation Planning Program. Study Report.

ERIC Educational Resources Information Center

Cook, Donald C.; And Others

This final report is a product of a Preservation Planning Program (PPP) self-study conducted by the State University of New York (SUNY), Stony Brook, working with the Association of Research Libraries' (ARL) Office of Management Studies (OMS). The PPP is designed to put self-help tools into the hands of library staff responsible for developing…

Comparative Study of Periodical Literature Indexing: Print versus Electronic Access. Final Report.

ERIC Educational Resources Information Center

Lowry, Charles B.

This 2-year project at the University of Texas at Arlington (UTA) was conducted to determine the feasibility of providing online periodical indexing to the journal holdings of the UTA libraries by demonstrating an extended use of the libraries' NOTIS Online Public Access Catalog (OPAC) to provide better access to local resources. Three approaches…

A Quantitative Inventory of Resource Development and Utilization for Metropolitan High School Students. Final Report.

ERIC Educational Resources Information Center

Drott, M. Carl; And Others

This study describes materials used by secondary school students in preparing independent study papers and other types of assignments calling for library use, including the use of home collections and school, public, college, and special libraries. Bibliometric methods were used to provide measurement of the nature and currency of books,…

A Testbed for Advancing the Role of Digital Technologies for Library Preservation and Access. Final Report.

ERIC Educational Resources Information Center

Kenney, Anne R.; Personius, Lynne K.

In cooperation with the Commission on Preservation and Access, Xerox Corporation, Sun Microsystems, Inc., and the New York State Program for the Conservation and Preservation of Library Research Materials, Cornell University (New York) studied and established the effectiveness of digital technology to preserve and make available research library…

Koha@ESO Reloaded

NASA Astrophysics Data System (ADS)

Meakins, S.; Grothkopf, U.

2015-04-01

What happened to the ESO library's plan to use the open source software Koha as their new library system? After an intensive migration process, we finally went online in June 2012. We want to share some of our experiences, point out advantages and disadvantages of an open source system and show some highlights of Koha, especially the flexibility the system offers.

Pima Community College Facilities Specification for a Library/Student Center Prototype. Final [Report].

ERIC Educational Resources Information Center

Paulien, Daniel K.; Thibodeau, Yvonne

This document is a description of a prototype Library/Student Center designed to serve approximately 10,000 students at a comprehensive campus. Prepared by the firm Paulien & Associates, Inc., of Denver, Colorado, this prototype will serve a design basis for facilities at all Pima Community College (PCC) campuses. The prototype will not be…

A Pilot Library Workshop on Term Paper Writing: Proposal and Final Report.

ERIC Educational Resources Information Center

Ames, Gregory P.

The first part of this two-part paper contains the original proposal for a college-level, team-taught library workshop designed for maximum interpersonal guidance on the mechanics of term paper preparation. It includes a survey of on-campus opportunities for students to receive help in developing their personal term paper skills, an assessment of…

Technology in the Service of Creativity: Computer Assisted Writing Project--Stetson Middle School, Philadelphia, Pennsylvania. Final Report.

ERIC Educational Resources Information Center

Bender, Evelyn

The American Library Association's Carroll Preston Baber Research Award supported this project on the use, impact and feasibility of a computer assisted writing facility located in the library of Stetson Middle School in Philadelphia, an inner city school with a population of minority, "at risk" students. The writing facility consisted…

Finding Opportunity: Darcy Cahill--Baltimore County Public Library

ERIC Educational Resources Information Center

Library Journal, 2004

2004-01-01

Three months after Darcy Cahill was promoted to head the Randallstown branch of the Baltimore County Public Library (BCPL), at 6 a.m. on a Saturday morning, the branch suffered a devastating fire. When firefighters finally contained the blaze, she was shocked to see the building drenched and in disarray. This article gives a detailed description…

Pilot Test of the Online Public Access Catalog Project's User and Nonuser Questionnaires. Final Report.

ERIC Educational Resources Information Center

Markey, Karen

This report describes the pilot data collections and post-questionnaire interview activities of the Council on Library Resources (CLR)/Online Computer Library Center (OCLC) Online Public Access Project. The background of the project is briefly described, the purpose and adminstration of the post-questionnaire interviews are outlined, and pilot…

Current and future resources for functional metagenomics.

PubMed

Lam, Kathy N; Cheng, Jiujun; Engel, Katja; Neufeld, Josh D; Charles, Trevor C

2015-01-01

Functional metagenomics is a powerful experimental approach for studying gene function, starting from the extracted DNA of mixed microbial populations. A functional approach relies on the construction and screening of metagenomic libraries-physical libraries that contain DNA cloned from environmental metagenomes. The information obtained from functional metagenomics can help in future annotations of gene function and serve as a complement to sequence-based metagenomics. In this Perspective, we begin by summarizing the technical challenges of constructing metagenomic libraries and emphasize their value as resources. We then discuss libraries constructed using the popular cloning vector, pCC1FOS, and highlight the strengths and shortcomings of this system, alongside possible strategies to maximize existing pCC1FOS-based libraries by screening in diverse hosts. Finally, we discuss the known bias of libraries constructed from human gut and marine water samples, present results that suggest bias may also occur for soil libraries, and consider factors that bias metagenomic libraries in general. We anticipate that discussion of current resources and limitations will advance tools and technologies for functional metagenomics research.

[From library to clinical decision support systems: access of general practitioner to quality information].

PubMed

Fauquert, B

2012-09-01

Since 2003, the following tools have been implemented in Belgium for improving the access of general practioners to the EBM literature: the Digital Library for Health and the evidence-linker of the CEBAM, the portal EBMPracticeNet.be and the multidimensional electronic clinical decision support EBMeDS. The aim of this article is to show the progress achieved in the information dissemination toward the belgian general practioners, particularly the access from the electronic health record. From the literature published these last years, the opportunities cited by the users are for using EBM and the strong willingness for using these literature access in the future; the limits are the medical data coding, the irrelevance of the search results, the alerts fatigue induced by EBMeDS. The achievements done and planned for the new EBMPracticeNet guidelines portal and the EBMeDS system are explained in the aim of informing belgian healthcare professionals. These projects are claiming for lauching a participatory process in the production and dissemination of EBM information. The discussion is focused on the belgian healthcare system advantages, the solutions for a reasonable implementation of these projects and for increasing the place of an evidence-based information in the healthcare decision process. Finally the input of these projects to the continuing medical education and to the healthcare quality are discussed, in a context of multifactorial interaction healthcare design (complexity design).

DSMC (Defense Systems Management College) CALS (Computer-Aided Acquisition and Logistics Support) Briefing: Program Manager Course.

DTIC Science & Technology

1988-11-01

library . o Air Force Tech Order Management System - Final Report, library o DLA CALS 1988 Implementation Plan, library . Where to go for Additional...0. ~l l LU; 0. 0 0 2. o 3 0 I) 0 U no V) 4- C 4. U) 00 u c.C0 Cco C Cl) cc m~0-CU . d" CD 0 m mooc Er.C 0 .0> s -w 2 c IM CO (aC wi E 0 r. X 0-0 a 0...as well as wider application. The Air Force AFTOMS Automation Plan, a copy of which is in the library , has excellent discussions of the expected

The Impact of Library Tutorials on the Information Literacy Skills of Occupational Therapy and Physical Therapy Students in an Evidence-Based Practice Course: A Rubric Assessment.

PubMed

Schweikhard, April J; Hoberecht, Toni; Peterson, Alyssa; Randall, Ken

2018-01-01

This study measures how online library instructional tutorials implemented into an evidence-based practice course have impacted the information literacy skills of occupational and physical therapy graduate students. Through a rubric assessment of final course papers, this study compares differences in students' search strategies and cited sources pre- and post-implementation of the tutorials. The population includes 180 randomly selected graduate students from before and after the library tutorials were introduced into the course curriculum. Results indicate a statistically significant increase in components of students' searching skills and ability to find higher levels of evidence after completing the library tutorials.

Human Resources in the Library System. Course 2, Leader's Handbook, Part 2: Aids (Volume 2). Final Report, Phase 2, Post-Master's Education for Middle and Upper-Level Personnel in Libraries and Information Centers.

ERIC Educational Resources Information Center

Goodman, Charles H.; Stone, Elizabeth W.

The aids to be used in a course designed for the continuing education of professional librarians on human resources in the library have been compiled in two volumes. The second of these contains films, cassettes, games, and readings. The film section has a list of films in the order that they are to be used in the course, as well as a directory of…

Genetics Home Reference: progressive supranuclear palsy

MedlinePlus

... Accessibility FOIA Viewers & Players U.S. Department of Health & Human Services National Institutes of Health National Library of Medicine Lister Hill National Center for Biomedical Communications 8600 Rockville Pike, Bethesda, MD 20894, USA HONCode ...

Software Quality Assurance and Verification for the MPACT Library Generation Process

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Yuxuan; Williams, Mark L.; Wiarda, Dorothea

This report fulfills the requirements for the Consortium for the Advanced Simulation of Light-Water Reactors (CASL) milestone L2:RTM.P14.02, “SQA and Verification for MPACT Library Generation,” by documenting the current status of the software quality, verification, and acceptance testing of nuclear data libraries for MPACT. It provides a brief overview of the library generation process, from general-purpose evaluated nuclear data files (ENDF/B) to a problem-dependent cross section library for modeling of light-water reactors (LWRs). The software quality assurance (SQA) programs associated with each of the software used to generate the nuclear data libraries are discussed; specific tests within the SCALE/AMPX andmore » VERA/XSTools repositories are described. The methods and associated tests to verify the quality of the library during the generation process are described in detail. The library generation process has been automated to a degree to (1) ensure that it can be run without user intervention and (2) to ensure that the library can be reproduced. Finally, the acceptance testing process that will be performed by representatives from the Radiation Transport Methods (RTM) Focus Area prior to the production library’s release is described in detail.« less

Common ground: the HealthWeb project as a model for Internet collaboration.

PubMed Central

Redman, P M; Kelly, J A; Albright, E D; Anderson, P F; Mulder, C; Schnell, E H

1997-01-01

The establishment of the HealthWeb project by twelve health sciences libraries provides a collaborative means of organizing and enhancing access to Internet resources for the international health sciences community. The project is based on the idea that the Internet is common ground for all libraries and that through collaboration a more comprehensive, robust, and long-lasting information product can be maintained. The participants include more than seventy librarians from the health sciences libraries of the Committee on Institutional Cooperation (CIC), an academic consortium of twelve major research universities. The Greater Midwest Region of the National Network of Libraries of Medicine serves as a cosponsor. HealthWeb is an information resource that provides access to evaluated, annotated Internet resources via the World Wide Web. The project vision as well as the progress reported on its implementation may serve as a model for other collaborative Internet projects. PMID:9431420

Systematic Analysis of Cell Cycle Effects of Common Drugs Leads to the Discovery of a Suppressive Interaction between Gemfibrozil and Fluoxetine

PubMed Central

Hoose, Scott A.; Duran, Camille; Malik, Indranil; Eslamfam, Shabnam; Shasserre, Samantha C.; Downing, S. Sabina; Hoover, Evelyn M.; Dowd, Katherine E.; Smith, Roger; Polymenis, Michael

2012-01-01

Screening chemical libraries to identify compounds that affect overall cell proliferation is common. However, in most cases, it is not known whether the compounds tested alter the timing of particular cell cycle transitions. Here, we evaluated an FDA-approved drug library to identify pharmaceuticals that alter cell cycle progression in yeast, using DNA content measurements by flow cytometry. This approach revealed strong cell cycle effects of several commonly used pharmaceuticals. We show that the antilipemic gemfibrozil delays initiation of DNA replication, while cells treated with the antidepressant fluoxetine severely delay progression through mitosis. Based on their effects on cell cycle progression, we also examined cell proliferation in the presence of both compounds. We discovered a strong suppressive interaction between gemfibrozil and fluoxetine. Combinations of interest among diverse pharmaceuticals are difficult to identify, due to the daunting number of possible combinations that must be evaluated. The novel interaction between gemfibrozil and fluoxetine suggests that identifying and combining drugs that show cell cycle effects might streamline identification of drug combinations with a pronounced impact on cell proliferation. PMID:22567160

Systematic analysis of cell cycle effects of common drugs leads to the discovery of a suppressive interaction between gemfibrozil and fluoxetine.

PubMed

Hoose, Scott A; Duran, Camille; Malik, Indranil; Eslamfam, Shabnam; Shasserre, Samantha C; Downing, S Sabina; Hoover, Evelyn M; Dowd, Katherine E; Smith, Roger; Polymenis, Michael

2012-01-01

Screening chemical libraries to identify compounds that affect overall cell proliferation is common. However, in most cases, it is not known whether the compounds tested alter the timing of particular cell cycle transitions. Here, we evaluated an FDA-approved drug library to identify pharmaceuticals that alter cell cycle progression in yeast, using DNA content measurements by flow cytometry. This approach revealed strong cell cycle effects of several commonly used pharmaceuticals. We show that the antilipemic gemfibrozil delays initiation of DNA replication, while cells treated with the antidepressant fluoxetine severely delay progression through mitosis. Based on their effects on cell cycle progression, we also examined cell proliferation in the presence of both compounds. We discovered a strong suppressive interaction between gemfibrozil and fluoxetine. Combinations of interest among diverse pharmaceuticals are difficult to identify, due to the daunting number of possible combinations that must be evaluated. The novel interaction between gemfibrozil and fluoxetine suggests that identifying and combining drugs that show cell cycle effects might streamline identification of drug combinations with a pronounced impact on cell proliferation.

Computer-Based Training for Library Staff: A Demonstration Project Using HyperCard. Final Performance Report.

ERIC Educational Resources Information Center

Bayne, Pauline S; Rader, Joe C.

The purpose of this project was to demonstrate that computer-based training (CBT) sessions, produced as HyperCard stacks (files), are an efficient and effective component for staff training in libraries. The purpose was successfully met in the 15-month period of development, evaluation, and implementation, and the University of Tennessee (UT)…

Systems Analysis of a University Library; Final Report on a Research Project.

ERIC Educational Resources Information Center

Buckland, Michael K.; And Others

The objectives of this study are to ensure that the resources at the disposal of the librarian are deployed in a manner which will effectively contribute to the purposes of the university. User behavior is explored in an attempt to solve the difficulties that arise in library planning and management, such as: (1) the relationship between length of…

A System for Inter-Library Communication (SILC). Final Report.

ERIC Educational Resources Information Center

Hayes, R. M.

A study was made of the use of time-sharing computer systems as a means of communication, accounting, message switching, and referral in a System for Inter-Library Communication (SILC). The purpose of the study was to develop data on which to evaluate the feasibility of such a system; the results are reported in terms of four issues: technical…

Institute for Training in Library Management and Communication Skills. Final Report.

ERIC Educational Resources Information Center

Chang, Henry C.; And Others

An institute held December 10-16, 1978, in the United States Virgin Islands, trained 25 middle-level library administrators in the use of communications as a management tool. The institute was part of an on-going program of staff development in a multi-cultural, disadvantaged area. The program was based on these objectives: (1) to introduce basic…

A Selective Stratistical Study of Transaction Activity in a Large On-Line Automated Circulation System. Final Report.

ERIC Educational Resources Information Center

Guthrie, Gerry D.

The objective of this study was to provide the library community with basic statistical data from on-line activity in the Ohio State University Libraries' Circulation System. Over 1.6 million archive records in the circulation system for 1972 were investigated to produce subject reports of circulation activity, activity reports by collection…

Rules for Input to the Library Catalog on Microfiche (A Guide to Librarians at the Eastman Kodak Company).

ERIC Educational Resources Information Center

Freund, Clare E.

The rules for catalog entries and punctuation outlined in this manual were used to prepare a computer-produced union catalog of the holdings of several libraries at the Eastman Kodak Company. The computer sorts digitally, considering first blanks, then punctuation marks, letters, and finally numbers. This results in a filing sequence which differs…

Economic Impact of the Hawaii State Public Library System (HSPLS) on the Business and Tourism Industries Study: Final Report

ERIC Educational Resources Information Center

Ryan, Joe; McClure, Charles R.

2003-01-01

Ryan Information Management conducted a return on investment (ROI) study of the economic value of the Hawaii State Public Library System (HSPLS) and identified potential additional sources of operating revenue. HSPLS economic value was examined from four viewpoints, HSPLS: direct economic impact, market value, peer comparison and value to library…

Colorado Academic Libraries Book Processing Center. Final Report, Phase I and Phase II (1 February 1967-30 April 1968).

ERIC Educational Resources Information Center

Leonard, Lawrence E.; And Others

This report summarizes the results of a fourteen-month study to (1) examine the feasibility of establishing a book processing center to serve the nine state-supported college and university libraries in Colorado and (2) conduct a simulation study of the proposed Center. The report covers: background, operational characteri tics of participating…

Supplementing the One-Shot Session: Tools to Enhance Instruction beyond the Computer Lab

ERIC Educational Resources Information Center

Becker, Bernd W.

2012-01-01

It is always a pleasure to stumble upon a discussion about library topics as they become mainstream issues. Some of the satisfaction is simply validation, knowing that the work librarians are doing has implications that extend beyond the library's four walls. But usually the author is excited that the rest of the world finally "gets it." Last…

Development of a Machine Form Union Catalog for the New England Library Information Network (NELINET). Final Report.

ERIC Educational Resources Information Center

Goldstein, Samuel; And Others

Based on a literature survey of union cataloging, and New England libraries it was determined that: (1) New England's collective union catalog needs and problems had not been specified, especially regarding the possibilities of machine application; (2) crucial data and analysis needed for such specification was unavailable; and (3) the absence of…

Clinical Trials: Key to Medical Progress

MedlinePlus

... consumer, and it has untold benefits for the public health, too." — National Library of Medicine Director Donald A. ... consumer, and it has untold benefits for the public health, too." How to Participate A variety of federal ...

Current and future resources for functional metagenomics

PubMed Central

Lam, Kathy N.; Cheng, Jiujun; Engel, Katja; Neufeld, Josh D.; Charles, Trevor C.

2015-01-01

Functional metagenomics is a powerful experimental approach for studying gene function, starting from the extracted DNA of mixed microbial populations. A functional approach relies on the construction and screening of metagenomic libraries—physical libraries that contain DNA cloned from environmental metagenomes. The information obtained from functional metagenomics can help in future annotations of gene function and serve as a complement to sequence-based metagenomics. In this Perspective, we begin by summarizing the technical challenges of constructing metagenomic libraries and emphasize their value as resources. We then discuss libraries constructed using the popular cloning vector, pCC1FOS, and highlight the strengths and shortcomings of this system, alongside possible strategies to maximize existing pCC1FOS-based libraries by screening in diverse hosts. Finally, we discuss the known bias of libraries constructed from human gut and marine water samples, present results that suggest bias may also occur for soil libraries, and consider factors that bias metagenomic libraries in general. We anticipate that discussion of current resources and limitations will advance tools and technologies for functional metagenomics research. PMID:26579102

Grant Closeout Requirements and Reports

Cancer.gov

Requirements and reports to comply with grant closeout, including Final Federal Financial Report (FFR, SF425); Final Research Performance Progress Report (FRPPR); Interim Research Performance Progress Report (IRPPR); Final Invention Statement (FIS, HHS

Building high-quality assay libraries for targeted analysis of SWATH MS data.

PubMed

Schubert, Olga T; Gillet, Ludovic C; Collins, Ben C; Navarro, Pedro; Rosenberger, George; Wolski, Witold E; Lam, Henry; Amodei, Dario; Mallick, Parag; MacLean, Brendan; Aebersold, Ruedi

2015-03-01

Targeted proteomics by selected/multiple reaction monitoring (S/MRM) or, on a larger scale, by SWATH (sequential window acquisition of all theoretical spectra) MS (mass spectrometry) typically relies on spectral reference libraries for peptide identification. Quality and coverage of these libraries are therefore of crucial importance for the performance of the methods. Here we present a detailed protocol that has been successfully used to build high-quality, extensive reference libraries supporting targeted proteomics by SWATH MS. We describe each step of the process, including data acquisition by discovery proteomics, assertion of peptide-spectrum matches (PSMs), generation of consensus spectra and compilation of MS coordinates that uniquely define each targeted peptide. Crucial steps such as false discovery rate (FDR) control, retention time normalization and handling of post-translationally modified peptides are detailed. Finally, we show how to use the library to extract SWATH data with the open-source software Skyline. The protocol takes 2-3 d to complete, depending on the extent of the library and the computational resources available.

Generation of human Fab antibody libraries: PCR amplification and assembly of light- and heavy-chain coding sequences.

PubMed

Andris-Widhopf, Jennifer; Steinberger, Peter; Fuller, Roberta; Rader, Christoph; Barbas, Carlos F

2011-09-01

The development of therapeutic antibodies for use in the treatment of human diseases has long been a goal for many researchers in the antibody field. One way to obtain these antibodies is through phage-display libraries constructed from human lymphocytes. This protocol describes the construction of human Fab (fragment antigen binding) antibody libraries. In this method, the individual rearranged heavy- and light-chain variable regions are amplified separately and are linked through a series of overlap polymerase chain reaction (PCR) steps to give the final Fab products that are used for cloning.

Study of an Audio Playback Machine Storage, Distribution, and Repair System. Options for Machine Operation. Study II, Part 1, Phase 2, Final Report.

ERIC Educational Resources Information Center

ManTech Technical Services Corp., Fairfax, VA.

This report presents the results of a management study of audio playback equipment operations conducted by the National Library Service, Library of Congress, its associated network of state and local machine lending agencies (MLA), and other parties that play a role in current operations. The objectives were to document current operations,…

Use of Census Bureau Data in GPO Depository Libraries: Future Issues and Trends. Final Report.

ERIC Educational Resources Information Center

McClure, Charles R.; Hernon, Peter

A discussion piece to assist the U.S. Bureau of the Census in planning for the effective use and dissemination of future census data and products in the Government Printing Office's Depository Library Program (DLP), this report identifies key issues that may affect the role of the DLP in providing the public with access to Census Bureau data. The…

Investigation of the Public Library as a Linking Agent to Major Scientific, Educational, Social, and Environmental Data Bases. Final Report.

ERIC Educational Resources Information Center

Lockheed Research Lab., Palo Alto, CA.

The DIALIB Project was a 3-year experiment that investigated the potential of the public library as a "linking agent" between the public and the many machine-readable data bases currently accessible via the telephone using online terminals. The study investigated the following questions: (1) Is online search of use to the patrons of a…

Investigation of the Searching Efficiency and Cost of Creating a Remote Access Catalog for the New York State Library. Final Report.

ERIC Educational Resources Information Center

Buckland, Lawrence F.; Madden, Mary

From experimental work performed, and reported upon in this document, it is concluded that converting the New York State Library (NYSL) shelf list sample to machine readable form, and searching this shelf list using a remote access catalog are technically sound concepts though the capital costs of data conversion and system installation will be…

LSCA Final Reports: Second Series.

ERIC Educational Resources Information Center

Clark, Collin, Ed.

This document includes final summary reports from recent federally funded Library Services and Construction Act (LSCA) demonstration projects in California. While some projects reported at length and others provided the bare facts, reports are excerpted but published as received, without editing beyond a uniform first page. The Summary Report Form…

LSCA Final Reports: Third Series.

ERIC Educational Resources Information Center

Clark, Collin, Ed.

This document includes final summary reports from 16 recent federally funded Library Services and Construction Act (LSCA) projects in California. This volume covers generally the period 1984-85, and reports are presented in six subject areas: programs for children, information and referral projects, institutional services, literacy, local history,…

BRAF Mutation is Associated with an Improved Survival in Glioma-a Systematic Review and Meta-analysis.

PubMed

Vuong, Huy Gia; Altibi, Ahmed M A; Duong, Uyen N P; Ngo, Hanh T T; Pham, Thong Quang; Fung, Kar-Ming; Hassell, Lewis

2018-05-01

Newly emerged molecular markers in gliomas provide prognostic values beyond the capabilities of histologic classification. BRAF mutation, especially BRAF V600E, is common in a subset of gliomas and may represent a potential prognostic marker. The aim of our study is to investigate the potential use of BRAF mutations on prognosis of glioma patients. Four electronic databases were searched for potential articles, including PubMed, Scopus, ISI Web of Science, and Virtual Health Library (VHL). Data of hazard ratio (HR) for overall survival (OS) and progression-free survival (PFS) were directly obtained from original papers or indirectly estimated from Kaplan Meier curve (KMC). A random effect model weighted by inverse variance method was used to calculate the pooled HR. From 705 articles, we finally included 11 articles with 1308 glioma patients for the final analysis. The overall estimates showed that BRAF V600E was associated with an improved overall survival (OS) in glioma patients (HR = 0.60; 95% CI = 0.44-0.80). Results for progression-free survival (PFS), however, were not statistically significant (HR = 1.39; 95% CI = 0.82-2.34). In subgroup analyses, BRAF V600E showed its effect in improving survival in pediatric and young adult gliomas (under 35 years) but did not have prognostic value in old adult. Additionally, BRAF V600E was only associated with a favorable prognosis in lower grade glioma. Our meta-analysis provides evidence that BRAF mutation has a favorable prognostic impact in gliomas and its prognostic value might be dependent on patient age and tumor grade. This mutation can be used as a prognostic factor in glioma but additional studies are required to clarify its prognostic value taking into account other confounding factors.

A Molecular Framework for Understanding DCIS

DTIC Science & Technology

2015-10-01

progressing from DCIS to IDC, with the purpose of reducing the need for over treatment for this disease . 2. Body Biopsies are analyzed in two...to DCIS, stroma adjacent to IDC, atypia lesions, Stroma away from disease , normal ductal epithelium and immune infiltrates. We have sequenced 500...DNA libraries we plan be able to answer the question of whether DCIS is a clonal disease , and if IDC is an independent disease or is a progression from

Digital Preservation and Deep Infrastructure; Dublin Core Metadata Initiative Progress Report and Workplan for 2002; Video Gaming, Education and Digital Learning Technologies: Relevance and Opportunities; Digital Collections of Real World Objects; The MusArt Music-Retrieval System: An Overview; eML: Taking Mississippi Libraries into the 21st Century.

ERIC Educational Resources Information Center

Granger, Stewart; Dekkers, Makx; Weibel, Stuart L.; Kirriemuir, John; Lensch, Hendrik P. A.; Goesele, Michael; Seidel, Hans-Peter; Birmingham, William; Pardo, Bryan; Meek, Colin; Shifrin, Jonah; Goodvin, Renee; Lippy, Brooke

2002-01-01

One opinion piece and five articles in this issue discuss: digital preservation infrastructure; accomplishments and changes in the Dublin Core Metadata Initiative in 2001 and plans for 2002; video gaming and how it relates to digital libraries and learning technologies; overview of a music retrieval system; and the online version of the…

Photons Revisited

NASA Astrophysics Data System (ADS)

Batic, Matej; Begalli, Marcia; Han, Min Cheol; Hauf, Steffen; Hoff, Gabriela; Kim, Chan Hyeong; Kim, Han Sung; Grazia Pia, Maria; Saracco, Paolo; Weidenspointner, Georg

2014-06-01

A systematic review of methods and data for the Monte Carlo simulation of photon interactions is in progress: it concerns a wide set of theoretical modeling approaches and data libraries available for this purpose. Models and data libraries are assessed quantitatively with respect to an extensive collection of experimental measurements documented in the literature to determine their accuracy; this evaluation exploits rigorous statistical analysis methods. The computational performance of the associated modeling algorithms is evaluated as well. An overview of the assessment of photon interaction models and results of the experimental validation are presented.

Development of High Throughput Process for Constructing 454 Titanium and Illumina Libraries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deshpande, Shweta; Hack, Christopher; Tang, Eric

2010-05-28

We have developed two processes with the Biomek FX robot to construct 454 titanium and Illumina libraries in order to meet the increasing library demands. All modifications in the library construction steps were made to enable the adaptation of the entire processes to work with the 96-well plate format. The key modifications include the shearing of DNA with Covaris E210 and the enzymatic reaction cleaning and fragment size selection with SPRI beads and magnetic plate holders. The construction of 96 Titanium libraries takes about 8 hours from sheared DNA to ssDNA recovery. The processing of 96 Illumina libraries takes lessmore » time than that of the Titanium library process. Although both processes still require manual transfer of plates from robot to other work stations such as thermocyclers, these robotic processes represent about 12- to 24-folds increase of library capacity comparing to the manual processes. To enable the sequencing of many libraries in parallel, we have also developed sets of molecular barcodes for both library types. The requirements for the 454 library barcodes include 10 bases, 40-60percent GC, no consecutive same base, and no less than 3 bases difference between barcodes. We have used 96 of the resulted 270 barcodes to construct libraries and pool to test the ability of accurately assigning reads to the right samples. When allowing 1 base error occurred in the 10 base barcodes, we could assign 99.6percent of the total reads and 100percent of them were uniquely assigned. As for the Illumina barcodes, the requirements include 4 bases, balanced GC, and at least 2 bases difference between barcodes. We have begun to assess the ability to assign reads after pooling different number of libraries. We will discuss the progress and the challenges of these scale-up processes.« less

HEP data analysis using jHepWork and Java.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chekanov, S.; High Energy Physics

2009-03-23

A role of Java in high-energy physics (HEP) and recent progress in development of a platform-independent data-analysis framework, jHepWork, is discussed. The framework produces professional graphics and has many libraries for data manipulation.

A Robust and Versatile Method of Combinatorial Chemical Synthesis of Gene Libraries via Hierarchical Assembly of Partially Randomized Modules

PubMed Central

Popova, Blagovesta; Schubert, Steffen; Bulla, Ingo; Buchwald, Daniela; Kramer, Wilfried

2015-01-01

A major challenge in gene library generation is to guarantee a large functional size and diversity that significantly increases the chances of selecting different functional protein variants. The use of trinucleotides mixtures for controlled randomization results in superior library diversity and offers the ability to specify the type and distribution of the amino acids at each position. Here we describe the generation of a high diversity gene library using tHisF of the hyperthermophile Thermotoga maritima as a scaffold. Combining various rational criteria with contingency, we targeted 26 selected codons of the thisF gene sequence for randomization at a controlled level. We have developed a novel method of creating full-length gene libraries by combinatorial assembly of smaller sub-libraries. Full-length libraries of high diversity can easily be assembled on demand from smaller and much less diverse sub-libraries, which circumvent the notoriously troublesome long-term archivation and repeated proliferation of high diversity ensembles of phages or plasmids. We developed a generally applicable software tool for sequence analysis of mutated gene sequences that provides efficient assistance for analysis of library diversity. Finally, practical utility of the library was demonstrated in principle by assessment of the conformational stability of library members and isolating protein variants with HisF activity from it. Our approach integrates a number of features of nucleic acids synthetic chemistry, biochemistry and molecular genetics to a coherent, flexible and robust method of combinatorial gene synthesis. PMID:26355961

A Robust and Versatile Method of Combinatorial Chemical Synthesis of Gene Libraries via Hierarchical Assembly of Partially Randomized Modules.

PubMed

Popova, Blagovesta; Schubert, Steffen; Bulla, Ingo; Buchwald, Daniela; Kramer, Wilfried

2015-01-01

A major challenge in gene library generation is to guarantee a large functional size and diversity that significantly increases the chances of selecting different functional protein variants. The use of trinucleotides mixtures for controlled randomization results in superior library diversity and offers the ability to specify the type and distribution of the amino acids at each position. Here we describe the generation of a high diversity gene library using tHisF of the hyperthermophile Thermotoga maritima as a scaffold. Combining various rational criteria with contingency, we targeted 26 selected codons of the thisF gene sequence for randomization at a controlled level. We have developed a novel method of creating full-length gene libraries by combinatorial assembly of smaller sub-libraries. Full-length libraries of high diversity can easily be assembled on demand from smaller and much less diverse sub-libraries, which circumvent the notoriously troublesome long-term archivation and repeated proliferation of high diversity ensembles of phages or plasmids. We developed a generally applicable software tool for sequence analysis of mutated gene sequences that provides efficient assistance for analysis of library diversity. Finally, practical utility of the library was demonstrated in principle by assessment of the conformational stability of library members and isolating protein variants with HisF activity from it. Our approach integrates a number of features of nucleic acids synthetic chemistry, biochemistry and molecular genetics to a coherent, flexible and robust method of combinatorial gene synthesis.

Accountable Information Flow for Java-Based Web Applications

DTIC Science & Technology

2010-01-01

runtime library Swift server runtime Java servlet framework HTTP Web server Web browser Figure 2: The Swift architecture introduced an open-ended...On the server, the Java application code links against Swift’s server-side run-time library, which in turn sits on top of the standard Java servlet ...AFRL-RI-RS-TR-2010-9 Final Technical Report January 2010 ACCOUNTABLE INFORMATION FLOW FOR JAVA -BASED WEB APPLICATIONS

Cornell University Libraries. A Final Report from the Public Services Research Projects. Appropriate Public Services for Agricultural Research Faculty. One of a Series of Self-Studies and Research Projects.

ERIC Educational Resources Information Center

Olsen, Jan Kennedy; And Others

This paper reports a self-study undertaken at Cornell University's Albert R. Mann Library to explore appropriate public services for an agricultural research faculty. The study took place over a 22-month period and involved a literature review, development of a questionnaire, administration of the questionnaire, an experimental period of…

SELECTIVE DISSEMINATION OF INFORMATION--REVIEW OF SELECTED SYSTEMS AND A DESIGN FOR ARMY TECHNICAL LIBRARIES. FINAL REPORT. ARMY TECHNICAL LIBRARY IMPROVEMENT STUDIES (ATLIS), REPORT NO. 8.

ERIC Educational Resources Information Center

BIVONA, WILLIAM A.

THIS REPORT PRESENTS AN ANALYSIS OF OVER EIGHTEEN SMALL, INTERMEDIATE, AND LARGE SCALE SYSTEMS FOR THE SELECTIVE DISSEMINATION OF INFORMATION (SDI). SYSTEMS ARE COMPARED AND ANALYZED WITH RESPECT TO DESIGN CRITERIA AND THE FOLLOWING NINE SYSTEM PARAMETERS--(1) INFORMATION INPUT, (2) METHODS OF INDEXING AND ABSTRACTING, (3) USER INTEREST PROFILE…

SELECTIVE DISSEMINATION OF INFORMATION (SDI). VOLUME I, PILOT TEST AT U.S. ARMY NATICK LABORATORIES. FINAL REPORT. ARMY TECHNICAL LIBRARY IMPROVEMENT STUDIES (ATLIS), REPORT NO. 15.

ERIC Educational Resources Information Center

BIVONA, WILLIAM A.

THIS VOLUME PRESENTS THE RESULTS OF A NINE-MONTH TEST OF A PROTOTYPE SELECTIVE DISSEMINATION OF INFORMATION (SDI) SYSTEM DEVELOPED FOR THE ARMY TECHNICAL LIBRARIES. DURING THE PILOT TEST ONE THOUSAND DOCUMENTS WERE CATALOGED, INDEXED, AND DISSEMINATED TO TWENTY-FIVE SCIENTIFIC AND TECHNICAL PERSONNEL. MATCHING OF THE INTEREST PROFILES OF THESE…

Comparative Analysis of Fruit Ripening-Related miRNAs and Their Targets in Blueberry Using Small RNA and Degradome Sequencing

PubMed Central

Hou, Yanming; Zhai, Lulu; Li, Xuyan; Xue, Yu; Wang, Jingjing; Yang, Pengjie; Cao, Chunmei; Li, Hongxue; Cui, Yuhai; Bian, Shaomin

2017-01-01

MicroRNAs (miRNAs) play vital roles in the regulation of fruit development and ripening. Blueberry is an important small berry fruit crop with economical and nutritional value. However, nothing is known about the miRNAs and their targets involved in blueberry fruit ripening. In this study, using high-throughput sequencing of small RNAs, 84 known miRNAs belonging to 28 families and 16 novel miRNAs were identified in white fruit (WF) and blue fruit (BF) libraries, which represent fruit ripening onset and in progress, respectively. Among them, 41 miRNAs were shown to be differentially expressed during fruit maturation, and 16 miRNAs representing 16 families were further chosen to validate the sRNA sequencing data by stem-loop qRT-PCR. Meanwhile, 178 targets were identified for 41 known and 7 novel miRNAs in WF and BF libraries using degradome sequencing, and targets of miR160 were validated using RLM-RACE (RNA Ligase-Mediated (RLM)-Rapid Amplification of cDNA Ends) approach. Moreover, the expression patterns of 6 miRNAs and their targets were examined during fruit development and ripening. Finally, integrative analysis of miRNAs and their targets revealed a complex miRNA-mRNA regulatory network involving a wide variety of biological processes. The findings will facilitate future investigations of the miRNA-mediated mechanisms that regulate fruit development and ripening in blueberry. PMID:29257112

Workflows for Full Waveform Inversions

NASA Astrophysics Data System (ADS)

Boehm, Christian; Krischer, Lion; Afanasiev, Michael; van Driel, Martin; May, Dave A.; Rietmann, Max; Fichtner, Andreas

2017-04-01

Despite many theoretical advances and the increasing availability of high-performance computing clusters, full seismic waveform inversions still face considerable challenges regarding data and workflow management. While the community has access to solvers which can harness modern heterogeneous computing architectures, the computational bottleneck has fallen to these often manpower-bounded issues that need to be overcome to facilitate further progress. Modern inversions involve huge amounts of data and require a tight integration between numerical PDE solvers, data acquisition and processing systems, nonlinear optimization libraries, and job orchestration frameworks. To this end we created a set of libraries and applications revolving around Salvus (http://salvus.io), a novel software package designed to solve large-scale full waveform inverse problems. This presentation focuses on solving passive source seismic full waveform inversions from local to global scales with Salvus. We discuss (i) design choices for the aforementioned components required for full waveform modeling and inversion, (ii) their implementation in the Salvus framework, and (iii) how it is all tied together by a usable workflow system. We combine state-of-the-art algorithms ranging from high-order finite-element solutions of the wave equation to quasi-Newton optimization algorithms using trust-region methods that can handle inexact derivatives. All is steered by an automated interactive graph-based workflow framework capable of orchestrating all necessary pieces. This naturally facilitates the creation of new Earth models and hopefully sparks new scientific insights. Additionally, and even more importantly, it enhances reproducibility and reliability of the final results.

Using experimental and computational energy equilibration to understand hierarchical self-assembly of Fmoc-dipeptide amphiphiles.

PubMed

Sasselli, I R; Pappas, C G; Matthews, E; Wang, T; Hunt, N T; Ulijn, R V; Tuttle, T

2016-10-12

Despite progress, a fundamental understanding of the relationships between the molecular structure and self-assembly configuration of Fmoc-dipeptides is still in its infancy. In this work, we provide a combined experimental and computational approach that makes use of free energy equilibration of a number of related Fmoc-dipeptides to arrive at an atomistic model of Fmoc-threonine-phenylalanine-amide (Fmoc-TF-NH 2 ) which forms twisted fibres. By using dynamic peptide libraries where closely related dipeptide sequences are dynamically exchanged to eventually favour the formation of the thermodynamically most stable configuration, the relative importance of C-terminus modifications (amide versus methyl ester) and contributions of aliphatic versus aromatic amino acids (phenylalanine F vs. leucine L) is determined (F > L and NH 2 > OMe). The approach enables a comparative interpretation of spectroscopic data, which can then be used to aid the construction of the atomistic model of the most stable structure (Fmoc-TF-NH 2 ). The comparison of the relative stabilities of the models using molecular dynamic simulations and the correlation with experimental data using dynamic peptide libraries and a range of spectroscopy methods (FTIR, CD, fluorescence) allow for the determination of the nanostructure with atomistic resolution. The final model obtained through this process is able to reproduce the experimentally observed formation of intertwining fibres for Fmoc-TF-NH 2 , providing information of the interactions involved in the hierarchical supramolecular self-assembly. The developed methodology and approach should be of general use for the characterization of supramolecular structures.

The View Behind and Ahead: Implications of Certification *

PubMed Central

Darling, Louise

1973-01-01

The Medical Library Association's certification plan, never of real significance in employment and promotion practices in health sciences librarianship, does not reflect the many changes which have occurred in swift progression since adoption of the code in 1949. Solutions to the problems which have accumulated since then are sought in a brief examination of trends in credentialing and certification in the health professions and in the library field, both general and special. Emphasis is given to the historical development of provisions in the MLA Code for the Training and Certification of Medical Librarians, the limited opportunity for practical implementation of most of the provisions, the importance of the code in stimulating the Association's educational programs, the impact of the Medical Library Assistance Act, Regional Medical Programs, and increases in demand for health information on manpower requirements for health science libraries, the specific dissatisfactions MLA members have expressed over certification, and the role of the Ad Hoc Committee to Develop a New Certification Code. PMID:4744343

Integrating the Learning of Mathematics and Science Using Interactive Teaching and Learning Strategies

NASA Astrophysics Data System (ADS)

Holmes, Mark H.

2006-10-01

To help students grasp the intimate connections that exist between mathematics and its applications in other disciplines a library of interactive learning modules was developed. This library covers the mathematical areas normally studied by undergraduate students and is used in science courses at all levels. Moreover, the library is designed not just to provide critical connections across disciplines but to also provide longitudinal subject reinforcement as students progress in their studies. In the process of developing the modules a complete editing and publishing system was constructed that is optimized for automated maintenance and upgradeability of materials. The result is a single integrated production system for web-based educational materials. Included in this is a rigorous assessment program, involving both internal and external evaluations of each module. As will be seen, the formative evaluation obtained during the development of the library resulted in the modules successfully bridging multiple disciplines and breaking down the disciplinary barriers commonly found in their math and non-math courses.

Construction of random sheared fosmid library from Chinese cabbage and its use for Brassica rapa genome sequencing project.

PubMed

Park, Tae-Ho; Park, Beom-Seok; Kim, Jin-A; Hong, Joon Ki; Jin, Mina; Seol, Young-Joo; Mun, Jeong-Hwan

2011-01-01

As a part of the Multinational Genome Sequencing Project of Brassica rapa, linkage group R9 and R3 were sequenced using a bacterial artificial chromosome (BAC) by BAC strategy. The current physical contigs are expected to cover approximately 90% euchromatins of both chromosomes. As the project progresses, BAC selection for sequence extension becomes more limited because BAC libraries are restriction enzyme-specific. To support the project, a random sheared fosmid library was constructed. The library consists of 97536 clones with average insert size of approximately 40 kb corresponding to seven genome equivalents, assuming a Chinese cabbage genome size of 550 Mb. The library was screened with primers designed at the end of sequences of nine points of scaffold gaps where BAC clones cannot be selected to extend the physical contigs. The selected positive clones were end-sequenced to check the overlap between the fosmid clones and the adjacent BAC clones. Nine fosmid clones were selected and fully sequenced. The sequences revealed two completed gap filling and seven sequence extensions, which can be used for further selection of BAC clones confirming that the fosmid library will facilitate the sequence completion of B. rapa. Copyright © 2011. Published by Elsevier Ltd.

cDNA library construction of two human Demodexspecies.

PubMed

Niu, DongLing; Wang, RuiLing; Zhao, YaE; Yang, Rui; Hu, Li; Lei, YuYang; Dan, WeiChao

2017-06-01

The research of Demodex, a type of pathogen causing various dermatoses in animals and human beings, is lacking at RNA level. This study aims at extracting RNA and constructing cDNA library for Demodex. First, P. cuniculiand D. farinaewere mixed to establish homogenization method for RNA extraction. Second, D. folliculorumand D. breviswere collected and preserved in Trizol, which were mixed with D. farinaerespectively to extract RNA. Finally, cDNA library was constructed and its quality was assessed. The results indicated that for D. folliculorum& D. farinae, the recombination rate of cDNA library was 90.67% and the library titer was 7.50 × 104 pfu/ml. 17 of the 59 positive clones were predicted to be of D. folliculorum; For D. brevis& D. farinae, the recombination rate was 90.96% and the library titer was 7.85 x104 pfu/ml. 40 of the 59 positive clones were predicted to be of D. brevis. Further detection by specific primers demonstrated that mtDNA cox1, cox3and ATP6 detected from cDNA libraries had 96.52%-99.73% identities with the corresponding sequences in GenBank. In conclusion, the cDNA libraries constructed for Demodexmixed with D. farinaewere successful and could satisfy the requirements for functional genes detection.

Errors in CGAP xProfiler and cDNA DGED: the importance of library parsing and gene selection algorithms.

PubMed

Milnthorpe, Andrew T; Soloviev, Mikhail

2011-04-15

The Cancer Genome Anatomy Project (CGAP) xProfiler and cDNA Digital Gene Expression Displayer (DGED) have been made available to the scientific community over a decade ago and since then were used widely to find genes which are differentially expressed between cancer and normal tissues. The tissue types are usually chosen according to the ontology hierarchy developed by NCBI. The xProfiler uses an internally available flat file database to determine the presence or absence of genes in the chosen libraries, while cDNA DGED uses the publicly available UniGene Expression and Gene relational databases to count the sequences found for each gene in the presented libraries. We discovered that the CGAP approach often includes libraries from dependent or irrelevant tissues (one third of libraries were incorrect on average, with some tissue searches no correct libraries being selected at all). We also discovered that the CGAP approach reported genes from outside the selected libraries and may omit genes found within the libraries. Other errors include the incorrect estimation of the significance values and inaccurate settings for the library size cut-off values. We advocated a revised approach to finding libraries associated with tissues. In doing so, libraries from dependent or irrelevant tissues do not get included in the final library pool. We also revised the method for determining the presence or absence of a gene by searching the UniGene relational database, revised calculation of statistical significance and sorted the library cut-off filter. Our results justify re-evaluation of all previously reported results where NCBI CGAP expression data and tools were used.

Errors in CGAP xProfiler and cDNA DGED: the importance of library parsing and gene selection algorithms

PubMed Central

2011-01-01

Background The Cancer Genome Anatomy Project (CGAP) xProfiler and cDNA Digital Gene Expression Displayer (DGED) have been made available to the scientific community over a decade ago and since then were used widely to find genes which are differentially expressed between cancer and normal tissues. The tissue types are usually chosen according to the ontology hierarchy developed by NCBI. The xProfiler uses an internally available flat file database to determine the presence or absence of genes in the chosen libraries, while cDNA DGED uses the publicly available UniGene Expression and Gene relational databases to count the sequences found for each gene in the presented libraries. Results We discovered that the CGAP approach often includes libraries from dependent or irrelevant tissues (one third of libraries were incorrect on average, with some tissue searches no correct libraries being selected at all). We also discovered that the CGAP approach reported genes from outside the selected libraries and may omit genes found within the libraries. Other errors include the incorrect estimation of the significance values and inaccurate settings for the library size cut-off values. We advocated a revised approach to finding libraries associated with tissues. In doing so, libraries from dependent or irrelevant tissues do not get included in the final library pool. We also revised the method for determining the presence or absence of a gene by searching the UniGene relational database, revised calculation of statistical significance and sorted the library cut-off filter. Conclusion Our results justify re-evaluation of all previously reported results where NCBI CGAP expression data and tools were used. PMID:21496233

Subject cataloging practices in North American medical school libraries.

PubMed Central

Fredericksen, R B; Michael, H N

1976-01-01

A survey of North American medical school libraries was made to determine current trends in subject cataloging practices. First, responses from 114 of these libraries are recorded and analyzed in the following areas: subject heading authority lists employed; use of the divided versus the dictionary catalog; and the form in which local subject authority files are kept. Then, focusing on 78 libraries that use MeSH in combination with a divided catalog, a further analysis of responses is made concerning issues relating to subject cataloging practices: updating the subject catalog to conform to annual MeSH changes; use of guide cards in the catalog; use of MeSH subheadings; filing conventions; and related issues. An attempt is made to analyze the extent to which these libraries vary from NLM practices. Suggestions are offered for formulating subject cataloging practices for an individual library. Finally, while it is concluded that MeSH and the Current Catalog are useful tools, a more detailed explication of the use of MeSH and NLM cataloging practices would be beneficial. PMID:989741

Combined in vitro transcription and reverse transcription to amplify and label complex synthetic oligonucleotide probe libraries.

PubMed

Murgha, Yusuf; Beliveau, Brian; Semrau, Kassandra; Schwartz, Donald; Wu, Chao-Ting; Gulari, Erdogan; Rouillard, Jean-Marie

2015-06-01

Oligonucleotide microarrays allow the production of complex custom oligonucleotide libraries for nucleic acid detection-based applications such as fluorescence in situ hybridization (FISH). We have developed a PCR-free method to make single-stranded DNA (ssDNA) fluorescent probes through an intermediate RNA library. A double-stranded oligonucleotide library is amplified by transcription to create an RNA library. Next, dye- or hapten-conjugate primers are used to reverse transcribe the RNA to produce a dye-labeled cDNA library. Finally the RNA is hydrolyzed under alkaline conditions to obtain the single-stranded fluorescent probes library. Starting from unique oligonucleotide library constructs, we present two methods to produce single-stranded probe libraries. The two methods differ in the type of reverse transcription (RT) primer, the incorporation of fluorescent dye, and the purification of fluorescent probes. The first method employs dye-labeled reverse transcription primers to produce multiple differentially single-labeled probe subsets from one microarray library. The fluorescent probes are purified from excess primers by oligonucleotide-bead capture. The second method uses an RNA:DNA chimeric primer and amino-modified nucleotides to produce amino-allyl probes. The excess primers and RNA are hydrolyzed under alkaline conditions, followed by probe purification and labeling with amino-reactive dyes. The fluorescent probes created by the combination of transcription and reverse transcription can be used for FISH and to detect any RNA and DNA targets via hybridization.

A Model Scholar's Outpost on the Electronic Frontier. Final Performance Report, October 1993-September 1995.

ERIC Educational Resources Information Center

Phillips, Linda L.

This final report describes a two-year project to create a library-supported Scholar's Workstation that provides convenient, timely user access to information in or near the scholar's workplace, particularly in relation to environmental studies. The University of Tennessee, Knoxville (UTK) librarians demonstrated current and emerging information…

Evaluation of the Impact, Costs and Benefits of the Albuquerque Model Cities Library Materials and Cultural Centers. Final Report. Volume I and II.

ERIC Educational Resources Information Center

Zink, Lee B.; And Others

The purpose of this study was the examination of the Albuquerque Model Cities Library Materials and Cultural Centers and of their impact upon the community they serve. This was not a traditional cost/benefit study although it contains many of the aspects of such an analysis. The area served by the Centers is an area of relatively poor persons of…

Common Pitfalls in F77 Code Conversion

DTIC Science & Technology

2003-02-01

implementation versus another are the source of these errors rather than typography . It is well to use the practice of commenting-out original source file lines...identifier), every I in the format field must be replaced with f followed by an appropriate floating point format designator . Floating point numeric...helps even more. Finally, libraries are a major source of non-portablility[sic], with graphics libraries one of the chief culprits. We in Fusion

IFLA General Conference, 1986. Bibliographic Control Division. Section: Bibliography. Papers.

ERIC Educational Resources Information Center

International Federation of Library Associations and Institutions, The Hague (Netherlands).

Papers on bibliographic control presented at the 1986 International Federation of Library Associations (IFLA) conference include: (1) "Bibliographic Interchange/Coordination in Southeast Asia (Huck Tee Lim, Malaysia); (2) "Project for 'Chinese National Bibliography' and Its Progress" (Huang Jungui, China); (3) "Subject…

QUARTERLY TECHNICAL PROGRESS REPORT, JULY, AUGUST, SEPTEMBER 1966.

DTIC Science & Technology

Contents: Circuit research program; Hardware systems research; Software systems research program; Numerical methods, computer arithmetic and...artificial languages; Library automation; Illiac II service , use, and program development; IBM service , use, and program development; Problem specifications; Switching theory and logical design; General laboratory information.

Library Resources for Bac End Sequencing. Final Technical Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pieter J. de Jong

2000-10-01

Studies directed towards the specific aims outlined for this research award are summarized. The RPCI II Human Bac Library has been expanded by the addition of 6.9-fold genomic coverage. This segment has been generated from a MBOI partial digest of the same anonymous donor DNA used for the rest of the library. A new cloning vector, pTARBAC1, has been constructed and used in the construction of RPCI-II segment 5. This new cloning vector provides a new strategy in identifying targeted genomic regions and will greatly facilitate a large-scale analysis for positional cloning. A new maleCS7BC/6J mouse BAC library has beenmore » constructed. RPCI-23 contain 576 plates (approx 210,000 clones) and represents approximately 11-fold coverage of the mouse genome.« less

AFCI-2.0 Library of Neutron Cross Section Covariances

DOE Office of Scientific and Technical Information (OSTI.GOV)

Herman, M.; Herman,M.; Oblozinsky,P.

2011-06-26

Neutron cross section covariance library has been under development by BNL-LANL collaborative effort over the last three years. The primary purpose of the library is to provide covariances for the Advanced Fuel Cycle Initiative (AFCI) data adjustment project, which is focusing on the needs of fast advanced burner reactors. The covariances refer to central values given in the 2006 release of the U.S. neutron evaluated library ENDF/B-VII. The preliminary version (AFCI-2.0beta) has been completed in October 2010 and made available to the users for comments. In the final 2.0 release, covariances for a few materials were updated, in particular newmore » LANL evaluations for {sup 238,240}Pu and {sup 241}Am were adopted. BNL was responsible for covariances for structural materials and fission products, management of the library and coordination of the work, while LANL was in charge of covariances for light nuclei and for actinides.« less

Meeting information needs in health policy and public health: priorities for the National Library of Medicine and The National Network of Libraries of Medicine.

PubMed

Humphreys, B L

1998-12-01

Those seeking information in health policy and public health are not as well served as those seeking clinical information. Problems inhibiting access to health policy and public health information include the heterogeneity of professionals seeking the information, the distribution of relevant information across disciplines and information sources, scarcity of synthesized information useful to practitioners, lack of awareness of available services or training in their use, and lack of access to information technology or to knowledgeable librarians and information specialists. Since 1990, the National Library of Medicine and the National Network of Libraries of Medicine have been working to enhance information services in health policy and public health through expanding the coverage of the NLM collection, building new databases, and engaging in targeted outreach and training initiatives directed toward segments of the health policy and public health communities. Progress has been made, but more remains to be done. Recommendations arising from the meeting, Accessing Useful Information: Challenges in Health Policy and Public Health, will help NLM and the National Network of Libraries of Medicine to establish priorities and action plans for the next several years.

The Use of EST Expression Matrixes for the Quality Control of Gene Expression Data

PubMed Central

Milnthorpe, Andrew T.; Soloviev, Mikhail

2012-01-01

EST expression profiling provides an attractive tool for studying differential gene expression, but cDNA libraries' origins and EST data quality are not always known or reported. Libraries may originate from pooled or mixed tissues; EST clustering, EST counts, library annotations and analysis algorithms may contain errors. Traditional data analysis methods, including research into tissue-specific gene expression, assume EST counts to be correct and libraries to be correctly annotated, which is not always the case. Therefore, a method capable of assessing the quality of expression data based on that data alone would be invaluable for assessing the quality of EST data and determining their suitability for mRNA expression analysis. Here we report an approach to the selection of a small generic subset of 244 UniGene clusters suitable for identification of the tissue of origin for EST libraries and quality control of the expression data using EST expression information alone. We created a small expression matrix of UniGene IDs using two rounds of selection followed by two rounds of optimisation. Our selection procedures differ from traditional approaches to finding “tissue-specific” genes and our matrix yields consistency high positive correlation values for libraries with confirmed tissues of origin and can be applied for tissue typing and quality control of libraries as small as just a few hundred total ESTs. Furthermore, we can pick up tissue correlations between related tissues e.g. brain and peripheral nervous tissue, heart and muscle tissues and identify tissue origins for a few libraries of uncharacterised tissue identity. It was possible to confirm tissue identity for some libraries which have been derived from cancer tissues or have been normalised. Tissue matching is affected strongly by cancer progression or library normalisation and our approach may potentially be applied for elucidating the stage of normalisation in normalised libraries or for cancer staging. PMID:22412959

Arrayed antibody library technology for therapeutic biologic discovery.

PubMed

Bentley, Cornelia A; Bazirgan, Omar A; Graziano, James J; Holmes, Evan M; Smider, Vaughn V

2013-03-15

Traditional immunization and display antibody discovery methods rely on competitive selection amongst a pool of antibodies to identify a lead. While this approach has led to many successful therapeutic antibodies, targets have been limited to proteins which are easily purified. In addition, selection driven discovery has produced a narrow range of antibody functionalities focused on high affinity antagonism. We review the current progress in developing arrayed protein libraries for screening-based, rather than selection-based, discovery. These single molecule per microtiter well libraries have been screened in multiplex formats against both purified antigens and directly against targets expressed on the cell surface. This facilitates the discovery of antibodies against therapeutically interesting targets (GPCRs, ion channels, and other multispanning membrane proteins) and epitopes that have been considered poorly accessible to conventional discovery methods. Copyright © 2013. Published by Elsevier Inc.

Comparative analysis of machine learning methods in ligand-based virtual screening of large compound libraries.

PubMed

Ma, Xiao H; Jia, Jia; Zhu, Feng; Xue, Ying; Li, Ze R; Chen, Yu Z

2009-05-01

Machine learning methods have been explored as ligand-based virtual screening tools for facilitating drug lead discovery. These methods predict compounds of specific pharmacodynamic, pharmacokinetic or toxicological properties based on their structure-derived structural and physicochemical properties. Increasing attention has been directed at these methods because of their capability in predicting compounds of diverse structures and complex structure-activity relationships without requiring the knowledge of target 3D structure. This article reviews current progresses in using machine learning methods for virtual screening of pharmacodynamically active compounds from large compound libraries, and analyzes and compares the reported performances of machine learning tools with those of structure-based and other ligand-based (such as pharmacophore and clustering) virtual screening methods. The feasibility to improve the performance of machine learning methods in screening large libraries is discussed.

Digitizing an Analog Radiography Teaching File Under Time Constraint: Trade-Offs in Efficiency and Image Quality.

PubMed

Loehfelm, Thomas W; Prater, Adam B; Debebe, Tequam; Sekhar, Aarti K

2017-02-01

We digitized the radiography teaching file at Black Lion Hospital (Addis Ababa, Ethiopia) during a recent trip, using a standard digital camera and a fluorescent light box. Our goal was to photograph every radiograph in the existing library while optimizing the final image size to the maximum resolution of a high quality tablet computer, preserving the contrast resolution of the radiographs, and minimizing total library file size. A secondary important goal was to minimize the cost and time required to take and process the images. Three workers were able to efficiently remove the radiographs from their storage folders, hang them on the light box, operate the camera, catalog the image, and repack the radiographs back to the storage folder. Zoom, focal length, and film speed were fixed, while aperture and shutter speed were manually adjusted for each image, allowing for efficiency and flexibility in image acquisition. Keeping zoom and focal length fixed, which kept the view box at the same relative position in all of the images acquired during a single photography session, allowed unused space to be batch-cropped, saving considerable time in post-processing, at the expense of final image resolution. We present an analysis of the trade-offs in workflow efficiency and final image quality, and demonstrate that a few people with minimal equipment can efficiently digitize a teaching file library.

National Library of Medicine Celebrates 30 Years of Progress and Charts the Future | NIH MedlinePlus the Magazine

MedlinePlus

... described the genesis of the National Center for Biotechnology Information (NCBI); the Visible Human Project (a digital ... expand the publication and distribution of NIH MedlinePlus magazine, thousands and thousands more people will gain valuable, ...

Medical serials control systems by computer--a state of the art review.

PubMed

Brodman, E; Johnson, M F

1976-01-01

A review of the problems encountered in serials control systems is followed by a description of some of the present-day attempts to solve these problems. Specific networks are described, notably PHILSOM (developed at Washington University School of Medicine Library), the UCLA Biomedical Library's system, and OCLC in Columbus, Ohio. Finally, the role of minicomputers in present and future developments is discussed, and some cautious guesses are made on future directions in the field.

Survey of Bibliographies and Reference Works on Asia, Africa, Latin America, and Russia and East Europe and Compilation of Bibliographies on East Asia, South Asia, and Africa South of the Sahara for Undergraduate Libraries. Final Report.

ERIC Educational Resources Information Center

Morehouse, Ward

The project was concerned with developing three up-to-date, accurate bibliographies on Asia and Africa as resource guides and book selection tools for undergraduate libraries. Existing bibliographies and information on newer books favorably received in journals were entered on a computer system. A preliminary, unedited, unselected bibliography was…

Arizona State Museum "Culture Craft Saturdays--Serving At-Risk Populations" Institute of Museums and Library Services Grant Museums for America Program, 2007-2008 School Year. Final Evaluation Report

ERIC Educational Resources Information Center

Falk, Lisa; Powers, Stephen

2008-01-01

Background: The Arizona State Museum, Tucson, received a grant for the school year 2007-08 from the Institute of Museums and Library Services, Museum for America Programs. The goals of this grant were (1) to continue a vibrant, monthly offering of family programs at the Arizona State Museum (ASM) around the topic of museum exhibitions, (2) to…

Generation of human scFv antibody libraries: PCR amplification and assembly of light- and heavy-chain coding sequences.

PubMed

Andris-Widhopf, Jennifer; Steinberger, Peter; Fuller, Roberta; Rader, Christoph; Barbas, Carlos F

2011-09-01

The development of therapeutic antibodies for use in the treatment of human diseases has long been a goal for many researchers in the antibody field. One way to obtain these antibodies is through phage-display libraries constructed from human lymphocytes. This protocol describes the construction of human scFv (single chain antibody fragment) libraries using a short linker (GGSSRSS) or a long linker (GGSSRSSSSGGGGSGGGG). In this method, the individual rearranged heavy- and light-chain variable regions are amplified separately and are linked through a series of overlap polymerase chain reaction (PCR) steps to give the final scFv products that are used for cloning.

Fluorous Parallel Synthesis of A Hydantoin/Thiohydantoin Library

PubMed Central

Lu, Yimin; Zhang, Wei

2007-01-01

Fluorous tagging strategy is applied to solution-phase parallel synthesis of a library containing hydantoin and thiohydantoin analogs. Two perfluoroalkyl (Rf)-tagged α-amino esters each react with 6 aromatic aldehydes under reductive amination conditions. Twelve amino esters then each react with 10 isocyanates and isothiocyanates in parallel. The resulting 120 ureas and thioureas undergo spontaneous cyclization to form the corresponding hydantoins and thiohydantoins. The intermediate and final product purifications are performed with solid-phase extraction (SPE) over FluoroFlash™ cartridges, no chromatography is required. Using standard instruments and straightforward SPE technique, one chemist accomplished the 120-member library synthesis in less than 5 working days, including starting material synthesis and product analysis. PMID:15789556

77 FR 44221 - Notice of Availability of the Final Environmental Impact Statement for the Proposed Point Thomson...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-27

... will be issued after August 27, 2012. The Final EIS is not open for public comment. FOR FURTHER... after requests for an extension were received. Open house and public comment meetings were held between... EIS are available for review at the following public libraries and schools: Harold Kaveolook School...

78 FR 32269 - Notice of Availability of the Final Environmental Impact Statement/Environmental Impact Report...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-29

..., state and local levels. While CDFW has participated in the development of this joint EIS/ EIR, the... alternatives on the human and physical environment, including, but not limited to, effects on biological... inspection at several libraries and government offices. A full list of locations where the final EIS/EIR is...

ANSL-V: ENDF/B-V based multigroup cross-section libraries for Advanced Neutron Source (ANS) reactor studies. Supplement 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wright, R.Q.; Renier, J.P.; Bucholz, J.A.

1995-08-01

The original ANSL-V cross-section libraries (ORNL-6618) were developed over a period of several years for the physics analysis of the ANS reactor, with little thought toward including the materials commonly needed for shielding applications. Materials commonly used for shielding applications include calcium barium, sulfur, phosphorous, and bismuth. These materials, as well as {sup 6}Li, {sup 7}Li, and the naturally occurring isotopes of hafnium, have been added to the ANSL-V libraries. The gamma-ray production and gamma-ray interaction cross sections were completely regenerated for the ANSL-V 99n/44g library which did not exist previously. The MALOCS module was used to collapse the 99n/44gmore » coupled library to the 39n/44g broad- group library. COMET was used to renormalize the two-dimensional (2- D) neutron matrix sums to agree with the one-dimensional (1-D) averaged values. The FRESH module was used to adjust the thermal scattering matrices on the 99n/44g and 39n/44g ANSL-V libraries. PERFUME was used to correct the original XLACS Legendre polynomial fits to produce acceptable distributions. The final ANSL-V 99n/44g and 39n/44g cross-section libraries were both checked by running RADE. The AIM module was used to convert the master cross-section libraries from binary coded decimal to binary format (or vice versa).« less

State of the art of geoscience libraries and information services

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pruett, N.J.

Geoscience libraries and geoscience information services are closely related. Both are trying to meet the needs of the geoscientists for information and data. Both are also being affected by many trends: increased availability of personal computers; decreased costs of machine readable storage; increased availability of maps in digital format (Pallatto, 1986); progress in graphic displays and in developing Geographic Information System, (GIS) (Kelly and Phillips, 1986); development in artificial intelligence; and the availability of new formats (e.g. CD-ROM). Some additional factors are at work at changing the role of libraries: libraries are coming to recognize the impossibility of collecting everythingmore » and the validity of Bradford's Law unobtrustive studies of library reference services have pointed out that only 50% of the questions are answered correctly it is clear that the number of databases is increasing although good figures for specifically geoscience databases are not available; lists of numeric database are beginning to appear; evaluative (as opposed to purely descriptive) reviews of available bibliographic databases are beginning to appear; more and more libraries are getting online catalogs and results of studies of users of online catalog are being used to improve catalog design; and research is raising consciousness about the value of; and research is raising consciousness about the value of information. All these trends are having or will have an effect on geoscience information.« less

Synthetic Biology Toolbox for Controlling Gene Expression in the Cyanobacterium Synechococcus sp. strain PCC 7002

DOE Office of Scientific and Technical Information (OSTI.GOV)

Markley, Andrew L.; Begemann, Matthew B.; Clarke, Ryan E.

The application of synthetic biology requires characterized tools to precisely control gene expression. This toolbox of genetic parts previously did not exist for the industrially promising cyanobacterium, Synechococcus sp. strain PCC 7002. To address this gap, two orthogonal constitutive promoter libraries, one based on a cyanobacterial promoter and the other ported from Escherichia coli, were built and tested in PCC 7002. The libraries demonstrated 3 and 2.5 log dynamic ranges, respectively, but correlated poorly with E. coli expression levels. These promoter libraries were then combined to create and optimize a series of IPTG inducible cassettes. The resultant induction system hadmore » a 48-fold dynamic range and was shown to out-perform P trc constructs. Finally, a RBS library was designed and tested in PCC 7002. The presented synthetic biology toolbox will enable accelerated engineering of PCC 7002.« less

Synthetic Biology Toolbox for Controlling Gene Expression in the Cyanobacterium Synechococcus sp. strain PCC 7002

DOE PAGES

Markley, Andrew L.; Begemann, Matthew B.; Clarke, Ryan E.; ...

2014-09-12

The application of synthetic biology requires characterized tools to precisely control gene expression. This toolbox of genetic parts previously did not exist for the industrially promising cyanobacterium, Synechococcus sp. strain PCC 7002. To address this gap, two orthogonal constitutive promoter libraries, one based on a cyanobacterial promoter and the other ported from Escherichia coli, were built and tested in PCC 7002. The libraries demonstrated 3 and 2.5 log dynamic ranges, respectively, but correlated poorly with E. coli expression levels. These promoter libraries were then combined to create and optimize a series of IPTG inducible cassettes. The resultant induction system hadmore » a 48-fold dynamic range and was shown to out-perform P trc constructs. Finally, a RBS library was designed and tested in PCC 7002. The presented synthetic biology toolbox will enable accelerated engineering of PCC 7002.« less

Fifteen hundred guidelines and growing: the UK database of clinical guidelines.

PubMed

van Loo, John; Leonard, Niamh

2006-06-01

The National Library for Health offers a comprehensive searchable database of nationally approved clinical guidelines, called the Guidelines Finder. This resource, commissioned in 2002, is managed and developed by the University of Sheffield Health Sciences Library. The authors introduce the historical and political dimension of guidelines and the nature of guidelines as a mechanism to ensure clinical effectiveness in practice. The article then outlines the maintenance and organisation of the Guidelines Finder database itself, the criteria for selection, who publishes guidelines and guideline formats, usage of the Guidelines Finder service and finally looks at some lessons learnt from a local library offering a national service. Clinical guidelines are central to effective clinical practice at the national, organisational and individual level. The Guidelines Finder is one of the most visited resources within the National Library for Health and is successful in answering information needs related to specific patient care, clinical research, guideline development and education.

A basic list of recommended books and journals for support of clinical dentistry in a nondental library.

PubMed Central

Johnson, R C; Mason, F O; Sims, R H

1997-01-01

A basic list of 133 book and journal titles in dentistry is presented. The list is intended as a bibliographic selection tool for those libraries and health institutions that support clinical dentistry programs and services in the nondental school environment in the United States and Canada. The book and journal titles were selected by the membership of the Dental Section of the Medical Library Association (MLA). The Dental Section membership represents dental and other health sciences libraries and dental research institutions from the United States and Canada, as well as from other countries. The list was compiled and edited by the Ad Hoc Publications Committee of the Dental Section of MLA. The final list was reviewed and subsequently was approved for publication and distribution by the Dental Section of MLA during the section's 1996 annual meeting in Kansas City, Missouri. PMID:9285122

Cleveland's Multicultural Librarian: Eleanor (Edwards) Ledbetter, 1870-1954

ERIC Educational Resources Information Center

Jones, Plummer Alston, Jr.

2013-01-01

Eleanor (Edwards) Ledbetter, who served immigrant populations in Cleveland throughout most of the Progressive Era and the Great Depression, was one of the first librarians to advocate for multiculturalism (then called cultural pluralism) as opposed to Americanism. In providing multicultural and multilingual library services for immigrants,…

Research administration, state planning & research part II program : FY2012 at-a-glance.

DOT National Transportation Integrated Search

2012-01-01

This publication presents a summary of Research and Library funding statistics and project progress for Fiscal Year (FY) 2012. The tables on pages 2 through 7 list all MDOT-funded research projects by focus area that were active or completed during 2...

Research administration, state planning & research part II program : FY2013 at-a-glance.

DOT National Transportation Integrated Search

2014-01-01

This publication presents a summary of Research and Library funding statistics and project progress for Fiscal Year : (FY) 2013. The tables on pages 2 through 7 list all MDOT-funded research projects by topic area that were active : or completed duri...

Revisiting Professional Dispositions: Research Redux

ERIC Educational Resources Information Center

Bush, Gail; Jones, Jami L.

2011-01-01

As the authors progressed through their research agenda last year, they contributed an article to "School Library Monthly" entitled "Forecasting Professional Dispositions of School Librarians" (January 2011, 54-56) wherein they described a Delphi study they conducted in the fall of 2009 that identified professional dispositions based on responses…

Lopez Energy Alternatives project. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Forbes, R.B.

1985-01-01

The activities reported include: purchase of books and periodical subscriptions on energy-related topics for a community library; organization of energy-related workshops; and monitoring of solar radiation and wind. (LEW)

Only for "purely scientific" institutions: the Medical Library Association's Exchange, 1898-1950s.

PubMed

Connor, Jennifer J

2011-04-01

Centralized exchanges of scientific materials existed by the late nineteenth century, but they did not include medical publications. North American medical leaders therefore formed an association of institutions to run their own exchange: the Medical Library Association (MLA). After providing background to the exchange concept and the importance of institutional members for MLA, this article examines archival MLA correspondence to consider the role of its Exchange in the association's professional development before the 1950s. MLA's membership policy admitted only libraries open to the medical profession with a large number of volumes. But the correspondence of the MLA Executive Committee reveals that the committee constantly adjusted the definition of library membership: personal, public, sectarian, commercial, allied science, and the then-termed "colored" medical school libraries all were denied membership. Study of these decisions, using commercial and sectarian libraries as a focus, uncovers the primary justification for membership exclusions: a goal of operating a scientific exchange. Also, it shows that in this way, MLA shadowed policies and actions of the American Medical Association. Finally, the study suggests that the medical profession enforced its policies of exclusion through MLA, despite a proclaimed altruistic sharing of medical literature.

Scaling up the 454 Titanium Library Construction and Pooling of Barcoded Libraries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Phung, Wilson; Hack, Christopher; Shapiro, Harris

2009-03-23

We have been developing a high throughput 454 library construction process at the Joint Genome Institute to meet the needs of de novo sequencing a large number of microbial and eukaryote genomes, EST, and metagenome projects. We have been focusing efforts in three areas: (1) modifying the current process to allow the construction of 454 standard libraries on a 96-well format; (2) developing a robotic platform to perform the 454 library construction; and (3) designing molecular barcodes to allow pooling and sorting of many different samples. In the development of a high throughput process to scale up the number ofmore » libraries by adapting the process to a 96-well plate format, the key process change involves the replacement of gel electrophoresis for size selection with Solid Phase Reversible Immobilization (SPRI) beads. Although the standard deviation of the insert sizes increases, the overall quality sequence and distribution of the reads in the genome has not changed. The manual process of constructing 454 shotgun libraries on 96-well plates is a time-consuming, labor-intensive, and ergonomically hazardous process; we have been experimenting to program a BioMek robot to perform the library construction. This will not only enable library construction to be completed in a single day, but will also minimize any ergonomic risk. In addition, we have implemented a set of molecular barcodes (AKA Multiple Identifiers or MID) and a pooling process that allows us to sequence many targets simultaneously. Here we will present the testing of pooling a set of selected fosmids derived from the endomycorrhizal fungus Glomus intraradices. By combining the robotic library construction process and the use of molecular barcodes, it is now possible to sequence hundreds of fosmids that represent a minimal tiling path of this genome. Here we present the progress and the challenges of developing these scaled-up processes.« less

Medical serials control systems by computer--a state of the art review.

PubMed Central

Brodman, E; Johnson, M F

1976-01-01

A review of the problems encountered in serials control systems is followed by a description of some of the present-day attempts to solve these problems. Specific networks are described, notably PHILSOM (developed at Washington University School of Medicine Library), the UCLA Biomedical Library's system, and OCLC in Columbus, Ohio. Finally, the role of minicomputers in present and future developments is discussed, and some cautious guesses are made on future directions in the field. PMID:1247704

Affirming our commitment to research: the Medical Library Association's research policy statement: the process and findings.

PubMed

Grefsheim, Suzanne F; Rankin, Jocelyn A; Perry, Gerald J; McKibbon, K Ann

2008-04-01

Building on its 1995 research policy statement, the Medical Library Association (MLA) has issued a new research policy, The Research Imperative. This paper shares the background research that informed the new policy. Semi-structured interviews were conducted with fifty-one key informants representing various library types, functions, geographic locations, ages, and ethnicities. The grounded theory approach was used to analyze the resulting textual database. Additionally, to gather input from the membership as a whole, two open forums were held at MLA annual meetings. Key informant data indicated that the policy should provide roles for MLA in leadership, advocacy, collaboration, services, education, publishing, and development of a research agenda. Evidence-based library and information practice was emphasized. Six themes emerged to center the new policy: creation of a research culture, challenges, domains of research, research skills set, roles of stakeholders, and measurement of progress. Reflecting the interests and beliefs of the membership, The Research Imperative challenges MLA members to build a supportive culture that values and contributes to a research base that is recognized as an essential tool for future practice.

Standards for hospital libraries 2002

PubMed Central

Gluck, Jeannine Cyr; Hassig, Robin Ackley; Balogh, Leeni; Bandy, Margaret; Doyle, Jacqueline Donaldson; Kronenfeld, Michael R.; Lindner, Katherine Lois; Murray, Kathleen; Petersen, JoAn; Rand, Debra C.

2002-01-01

The Medical Library Association's “Standards for Hospital Libraries 2002” have been developed as a guide for hospital administrators, librarians, and accrediting bodies to ensure that hospitals have the resources and services to effectively meet their needs for knowledge-based information. Specific requirements for knowledge-based information include that the library be a separate department with its own budget. Knowledge-based information in the library should be directed by a qualified librarian who functions as a department head and is a member of the Academy of Health Information Professionals. The standards define the role of the medical librarian and the links between knowledge-based information and other functions such as patient care, patient education, performance improvement, and education. In addition, the standards address the development and implementation of the knowledge-based information needs assessment and plans, the promotion and publicity of the knowledge-based information services, and the physical space and staffing requirements. The role, qualifications, and functions of a hospital library consultant are outlined. The health sciences library is positioned to play a key role in the hospital. The increasing use of the Internet and new information technologies by medical, nursing, and allied health staffs; patients; and the community require new strategies, strategic planning, allocation of adequate resources, and selection and evaluation of appropriate information resources and technologies. The Hospital Library Standards Committee has developed this document as a guideline to be used in facing these challenges. Editor's Note: The “Standards for Hospital Libraries 2002” were approved by the members of the Hospital Library Section during MLA '02 in Dallas, Texas. They were subsequently approved by Section Council and received final approval from the MLA Board of Directors in June 2002. They succeed the Standards for Hospital Libraries published in 1994 and the Minimum Standards for Health Sciences Libraries in Hospitals from 1983. A Frequently Asked Questions document discussing the development of the new standards can be found on the Hospital Library Section Website at http://www.hls.mlanet.org. PMID:12398254

Genomic clones for human cholinesterase

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kott, M.; Venta, P.J.; Larsen, J.

1987-05-01

A human genomic library was prepared from peripheral white blood cells from a single donor by inserting an MboI partial digest into BamHI poly-linker sites of EMBL3. This library was screened using an oligolabeled human cholinesterase cDNA probe over 700 bp long. The latter probe was obtained from a human basal ganglia cDNA library. Of approximately 2 million clones screened with high stringency conditions several positive clones were identified; two have been plaque purified. One of these clones has been partially mapped using restriction enzymes known to cut within the coded region of the cDNA for human serum cholinesterase. Hybridizationmore » of the fragments and their sizes are as expected if the genomic clone is cholinesterase. Sequencing of the DNA fragments in M13 is in progress to verify the identify of the clone and the location of introns.« less

75 FR 34709 - Notice of Availability for the Final Environmental Impact Statement/Environmental Impact Report...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-18

... and H.P. Wright Library Branch. The Final EIS/EIR is available at the Corps' Web site: http://www.spl... includes a draft general conformity determination (see Section 3.2, Section 4.7 and Appendix D.7), pursuant to Section 176(c) of the Clean Air Act. A general conformity determination is necessary because...

Report on Information Retrieval and Library Automation Studies.

ERIC Educational Resources Information Center

Alberta Univ., Edmonton. Dept. of Computing Science.

Short abstracts of works in progress or completed in the Department of Computing Science at the University of Alberta are presented under five major headings. The five categories are: Storage and search techniques for document data bases, Automatic classification, Study of indexing and classification languages through computer manipulation of data…

Expanding Our Understanding of the Inquiry Process

ERIC Educational Resources Information Center

Stafford, Tish; Stemple, Jennifer

2011-01-01

School librarians know the importance of collaboration. They cannot run effective school library programs unless they work closely with classroom teachers. They have learned that deep collaboration is a fluid process that evolves over time. Only as connections are made and relationships are forged can real instructional progress occur. Yet it…

Development of an Urban Search and Rescue Robot

DTIC Science & Technology

2003-01-01

is a magnetorheological (MR) fluids shock absorber. The nature of this fluid is such that its compliance can be electronically adjusted thousands...simulators. First, ODE is still a work in progress. The user manual is far from finished and modifications to the coded library come out quite frequently...

Tunable intraparticle frameworks for creating complex heterostructured nanoparticle libraries

NASA Astrophysics Data System (ADS)

Fenton, Julie L.; Steimle, Benjamin C.; Schaak, Raymond E.

2018-05-01

Complex heterostructured nanoparticles with precisely defined materials and interfaces are important for many applications. However, rationally incorporating such features into nanoparticles with rigorous morphology control remains a synthetic bottleneck. We define a modular divergent synthesis strategy that progressively transforms simple nanoparticle synthons into increasingly sophisticated products. We introduce a series of tunable interfaces into zero-, one-, and two-dimensional copper sulfide nanoparticles using cation exchange reactions. Subsequent manipulation of these intraparticle frameworks yielded a library of 47 distinct heterostructured metal sulfide derivatives, including particles that contain asymmetric, patchy, porous, and sculpted nanoarchitectures. This generalizable mix-and-match strategy provides predictable retrosynthetic pathways to complex nanoparticle features that are otherwise inaccessible.

Writing academic papers: lost in translation?

PubMed

Grant, Maria J

2011-12-01

The process of writing for publication is a challenging one. It moves us from the spoken and written word into a realm that requires us to provide supporting evidence to develop an argument in a logical and progressive way. In English language journals, as elsewhere, the quality of the written word is a determining factor in the likelihood of a paper being accepted for publication. By reading past issues of a targeted journal, drawing on the expertise of colleagues and responding positively to feedback, it is possible to significantly enhance your prospects of publication. © 2011 The authors. Health Information and Libraries Journal © 2011 Health Libraries Group.

"De Cassini à l'an 2000": The Paris Observatory Library

NASA Astrophysics Data System (ADS)

Vallet, M.; Reymonet, N.

Paris Observatory founded in 1667 by Louis XIV is one of the so called "Grand Etablissement" under of the aegis of the Ministry of higher education and research, and includes two other centres: Meudon Observatory and the Radioastronomy centre in Nancay, created respectively in 1876 and 1955. The decree which gave birth to the library itself was signed in 1785 by Louis XVI. In 1926 Meudon is joined to Paris. The total number of bound volumes, including journals, is 100.000. This comprises 2000 periodical titles (of which 1200 are current titles), monographs, photographs, incunabula and manuscripts from the 16th to the 20th century, microfilm versions of historical material. The collections of two libraries are complementary. Starting in 1981, the library became part of a national "Centre d'Acquisition et de Diffusion de l'Information Scientifique et Technique" (CADIST) for astronomy and astrophysics documents. The catalogue is available on national networks such as the Pancatalogue or CCN. It may also be accessed on the international OCLC network. Finally the library may be accessed on internet via WWW.

Construction of 1,3,4-Oxadiazole and 1,3,4-Thiadiazole Library with a High Level of Skeletal Diversity Based on Branching Diversity-Oriented Synthesis on Solid-Phase Supports.

PubMed

Ha, Ji-Eun; Yang, Seung-Ju; Gong, Young-Dae

2018-02-12

An efficient solid-phase synthetic route for the construction of 1,3,4-oxadiazole and 1,3,4-thiadiazole libraries based on branching diversity-oriented synthesis (DOS) has been developed in this study. The core skeleton resins, 1,3,4-oxadiazole and 1,3,4-thiadiazole, were obtained through desulfurative and dehydrative cyclizations of thiosemicarbazide resin, respectively. Various functional groups have been introduced to the core skeleton resins, such as aryl, amine, amide, urea, thiourea, and an amino acid. Most of the libraries were purified by simple trituration without extraction or column chromatography after cleavage of the products from the solid-supported resin. As a result, we obtained high yields of pure 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives (total numbers = 128). Finally, we confirmed the drug-like properties of our library by calculation of physicochemical properties, displays of the skeletal diversities of the library in 3D-space, and occupation of a broad range of areas by their functional groups.

NaLi-H1: A universal synthetic library of humanized nanobodies providing highly functional antibodies and intrabodies

PubMed Central

Moutel, Sandrine; Bery, Nicolas; Bernard, Virginie; Keller, Laura; Lemesre, Emilie; de Marco, Ario; Ligat, Laetitia; Rain, Jean-Christophe; Favre, Gilles; Olichon, Aurélien; Perez, Franck

2016-01-01

In vitro selection of antibodies allows to obtain highly functional binders, rapidly and at lower cost. Here, we describe the first fully synthetic phage display library of humanized llama single domain antibody (NaLi-H1: Nanobody Library Humanized 1). Based on a humanized synthetic single domain antibody (hs2dAb) scaffold optimized for intracellular stability, the highly diverse library provides high affinity binders without animal immunization. NaLi-H1 was screened following several selection schemes against various targets (Fluorescent proteins, actin, tubulin, p53, HP1). Conformation antibodies against active RHO GTPase were also obtained. Selected hs2dAb were used in various immunoassays and were often found to be functional intrabodies, enabling tracking or inhibition of endogenous targets. Functionalization of intrabodies allowed specific protein knockdown in living cells. Finally, direct selection against the surface of tumor cells produced hs2dAb directed against tumor-specific antigens further highlighting the potential use of this library for therapeutic applications. DOI: http://dx.doi.org/10.7554/eLife.16228.001 PMID:27434673

Collection development using interlibrary loan borrowing and acquisitions statistics.

PubMed Central

Byrd, G D; Thomas, D A; Hughes, K E

1982-01-01

Libraries, especially those supporting the sciences, continually face the problem of selecting appropriate new books for their users. Traditional collection development techniques include the use of librarian or user subject specialists, user recommendations, and approval plans. These methods of selection, however, are most effective in large libraries and do not systemically correlate new book purchases with the actual demands of users served. This paper describes a statistical method for determining subject strengths and weaknesses in a library book collection in relation to user demand. Using interlibrary loan borrowing and book acquisition statistics gathered for one fiscal year from three health sciences libraries, the authors developed a way to graph the broad and narrow subject fields of strength and potential weakness in a book collection. This method has the advantages of simplicity, speed of implementation, and clarity. It can also be used over a period of time to verify the success or failure of a collection development program. Finally, the method has potential as a tool for use by two or more libraries seeking to improve cooperative collection development in a network or consortium. PMID:7059712

Application of clone library analysis and real-time PCR for comparison of microbial communities in a low-grade copper sulfide ore bioheap leachate.

PubMed

Bowei, Chen; Xingyu, Liu; Wenyan, Liu; Jiankang, Wen

2009-11-01

The microbial communities of leachate from a bioleaching heap located in China were analyzed using the 16S rRNA gene clone library and real-time quantitative PCR. Both methods showed that Leptospirillum spp. were the dominant bacteria, and Ferroplasma acidiphilum were the only archaea detected in the leachate. Clone library results indicated that nine operational taxonomic units (OTUs) were obtained, which fell into four divisions, the Nitrospirae (74%), the gamma-Proteobacteria (14%), the Actinobacteria (6%) and the Euryarchaeota (6%). The results obtained by real-time PCR in some ways were the same as clone library analysis. Furthermore, Sulfobacillus spp., detected only by real-time PCR, suggests that real-time PCR was a reliable technology to study the microbial communities in bioleaching environments. It is a useful tool to assist clone library analysis, to further understand microbial consortia and to have comprehensive and exact microbiological information about bioleaching environments. Finally, the interactions among the microorganisms detected in the leachate were summarized according to the characteristics of these species.

Expressed sequence tags from heat-shocked seagrass Zostera noltii (Hornemann) from its southern distribution range.

PubMed

Massa, Sónia I; Pearson, Gareth A; Aires, Tânia; Kube, Michael; Olsen, Jeanine L; Reinhardt, Richard; Serrão, Ester A; Arnaud-Haond, Sophie

2011-09-01

Predicted global climate change threatens the distributional ranges of species worldwide. We identified genes expressed in the intertidal seagrass Zostera noltii during recovery from a simulated low tide heat-shock exposure. Five Expressed Sequence Tag (EST) libraries were compared, corresponding to four recovery times following sub-lethal temperature stress, and a non-stressed control. We sequenced and analyzed 7009 sequence reads from 30min, 2h, 4h and 24h after the beginning of the heat-shock (AHS), and 1585 from the control library, for a total of 8594 sequence reads. Among 51 Tentative UniGenes (TUGs) exhibiting significantly different expression between libraries, 19 (37.3%) were identified as 'molecular chaperones' and were over-expressed following heat-shock, while 12 (23.5%) were 'photosynthesis TUGs' generally under-expressed in heat-shocked plants. A time course analysis of expression showed a rapid increase in expression of the molecular chaperone class, most of which were heat-shock proteins; which increased from 2 sequence reads in the control library to almost 230 in the 30min AHS library, followed by a slow decrease during further recovery. In contrast, 'photosynthesis TUGs' were under-expressed 30min AHS compared with the control library, and declined progressively with recovery time in the stress libraries, with a total of 29 sequence reads 24h AHS, compared with 125 in the control. A total of 4734 TUGs were screened for EST-Single Sequence Repeats (EST-SSRs) and 86 microsatellites were identified. Copyright © 2011 Elsevier B.V. All rights reserved.

Dynamic combinatorial libraries: new opportunities in systems chemistry.

PubMed

Hunt, Rosemary A R; Otto, Sijbren

2011-01-21

Combinatorial chemistry is a tool for selecting molecules with special properties. Dynamic combinatorial chemistry started off aiming to be just that. However, unlike ordinary combinatorial chemistry, the interconnectedness of dynamic libraries gives them an extra dimension. An understanding of these molecular networks at systems level is essential for their use as a selection tool and creates exciting new opportunities in systems chemistry. In this feature article we discuss selected examples and considerations related to the advanced exploitation of dynamic combinatorial libraries for their originally conceived purpose of identifying strong binding interactions. Also reviewed are examples illustrating a trend towards increasing complexity in terms of network behaviour and reversible chemistry. Finally, new applications of dynamic combinatorial chemistry in self-assembly, transport and self-replication are discussed.

Inquiry-based Learning and Digital Libraries in Undergraduate Science Education

NASA Astrophysics Data System (ADS)

Apedoe, Xornam S.; Reeves, Thomas C.

2006-12-01

The purpose of this paper is twofold: to describe robust rationales for integrating inquiry-based learning into undergraduate science education, and to propose that digital libraries are potentially powerful technological tools that can support inquiry-based learning goals in undergraduate science courses. Overviews of constructivism and situated cognition are provided with regard to how these two theoretical perspectives have influenced current science education reform movements, especially those that involve inquiry-based learning. The role that digital libraries can play in inquiry-based learning environments is discussed. Finally, the importance of alignment among critical pedagogical dimensions of an inquiry-based pedagogical framework is stressed in the paper, and an example of how this can be done is presented using earth science education as a context.

Parallel and automated library synthesis of 2-long alkyl chain benzoazoles and azole[4,5-b]pyridines under microwave irradiation.

PubMed

Martínez-Palou, Rafael; Zepeda, L Gerardo; Höpfl, Herbert; Montoya, Ascensión; Guzmán-Lucero, Diego J; Guzmán, Javier

2005-01-01

A versatile route to 40-membered library of 2-long alkyl chain substituted benzoazoles (1 and 2) and azole[4,5-b]pyridines (3 and 4) via microwave-assisted combinatorial synthesis was developed. The reactions were carried out in both monomode and multimode microwave oven. With the latter, all reactions were performed in high-throughput experimental settings consisting of an 8 x 5 combinatorial library designed to synthesize 40 compounds. Each step, from the addition of reagents to the recovery of final products, was automated. The microwave-assisted N-long chain alkylation reactions of 2-alkyl-1H-benzimidazole (1) and 2-alkyl-1H-benzimidazole[4,5-b] pyridines (3) were also studied.

Libraries of 2β-(N-substituted piperazino)-5α-androstane-3α, 17β-diols: chemical synthesis and cytotoxic effects on human leukemia HL-60 cells and on normal lymphocytes.

PubMed

Roy, Jenny; Maltais, René; Jegham, Hajer; Poirier, Donald

2011-05-01

Libraries of steroid derivatives with two levels of molecular diversity were prepared to optimize the antiproliferative activity on leukemia HL-60 cells by first varying the amino acid (AA) at R(1) (libraries A, B, C, and D: with 45, 45, 20, and 20 members, respectively) and, subsequently, the capping group at R(2) (library E: 168 members). The screening of these aminosteroids revealed interesting structure-activity relationships. In library A, the compounds bearing a tetrahydroisoquinolone residue as the first element of diversity showed potent cytotoxicity, principally when isovaleric or cyclohexyl acetic acid was used as a capping group (>40% of cell growth inhibition at 1 μM). In library B, the phenylalanine (Phe) derivatives bearing a cyano group induced a higher growth inhibition than the other Phe derivatives. The screening of library C indicated the increase of hydrophobicity of proline (Pro) seems to preserve the cytotoxic effect achieved by the lead compound. However, the synthesis of structural Pro variants (library D) clearly shows weaker activities when compared to L-Pro building blocks. Finally, by incorporating some of the most active AA of libraries A-D in library E, we observed that the amide coupling functionality gave stronger cytotoxic activity compared to the corresponding sulfonamides or benzylamines. Six of the most active amide derivatives (E-37P, E-41P, E-42P, E-46P, E-48F, and E-12T) were selected and IC(50) determined on HL-60 cells as well as on normal human lymphocytes. Among this series of new anticancer agents, good to high selectivity indices (SI = IC(50) (lymphocytes)/IC(50) (HL-60 cells) = 5 - 55) were obtained.

SLA truck configuration library final report.

DOT National Transportation Integrated Search

2016-10-31

Historically, the Texas Department of Transportation (TxDOT) State Legislative Affairs (SLA) : Section, TxDOT subject matter experts (SME) and the University of Texas Center for : Transportation Research (CTR) and University of Texas San Anto...

Accepting the challenge: what academic health sciences library directors do to become effective leaders.

PubMed

Fought, Rick L; Misawa, Mitsunori

2018-04-01

This study sought to better understand effective leadership through the lived experiences of academic health sciences library directors. Phenomenological interviews were conducted with eight academic health sciences library directors to capture the essence of their shared leadership experiences. The research question that guided the study was: How do academic health sciences library directors understand their leadership effectiveness? The interviews were transcribed and coded, and the data were analyzed thematically. Three main themes emerged from data after analysis: assessment of the environment, strategies and decisions, and critical skills. Assessment of the environment includes awareness not only of trends in libraries and technology, but also the trends in health information, higher education, and current events and politics of their institutions and states. The strategies and decisions theme is about the ability to think both in the long-term and short-term when leading the library. Finally, critical skills are those leadership skills that the research participants identified as most important to their leadership effectiveness. The study identified three main themes capturing the essence of the research participants' leadership experiences. The three themes constitute a wide array of leadership skills that are important to learn, understand, and develop to increase leadership effectiveness. Effective leadership is fundamental to obtaining long-term strategic goals and is critical to the long-term future of the libraries.

NSUF Irradiated Materials Library

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cole, James Irvin

The Nuclear Science User Facilities has been in the process of establishing an innovative Irradiated Materials Library concept for maximizing the value of previous and on-going materials and nuclear fuels irradiation test campaigns, including utilization of real-world components retrieved from current and decommissioned reactors. When the ATR national scientific user facility was established in 2007 one of the goals of the program was to establish a library of irradiated samples for users to access and conduct research through competitively reviewed proposal process. As part of the initial effort, staff at the user facility identified legacy materials from previous programs thatmore » are still being stored in laboratories and hot-cell facilities at the INL. In addition other materials of interest were identified that are being stored outside the INL that the current owners have volunteered to enter into the library. Finally, over the course of the last several years, the ATR NSUF has irradiated more than 3500 specimens as part of NSUF competitively awarded research projects. The Logistics of managing this large inventory of highly radioactive poses unique challenges. This document will describe materials in the library, outline the policy for accessing these materials and put forth a strategy for making new additions to the library as well as establishing guidelines for minimum pedigree needed to be included in the library to limit the amount of material stored indefinitely without identified value.« less

Accepting the challenge: what academic health sciences library directors do to become effective leaders

PubMed Central

Fought, Rick L.; Misawa, Mitsunori

2018-01-01

Objective This study sought to better understand effective leadership through the lived experiences of academic health sciences library directors. Methods Phenomenological interviews were conducted with eight academic health sciences library directors to capture the essence of their shared leadership experiences. The research question that guided the study was: How do academic health sciences library directors understand their leadership effectiveness? The interviews were transcribed and coded, and the data were analyzed thematically. Results Three main themes emerged from data after analysis: assessment of the environment, strategies and decisions, and critical skills. Assessment of the environment includes awareness not only of trends in libraries and technology, but also the trends in health information, higher education, and current events and politics of their institutions and states. The strategies and decisions theme is about the ability to think both in the long-term and short-term when leading the library. Finally, critical skills are those leadership skills that the research participants identified as most important to their leadership effectiveness. Conclusions The study identified three main themes capturing the essence of the research participants’ leadership experiences. The three themes constitute a wide array of leadership skills that are important to learn, understand, and develop to increase leadership effectiveness. Effective leadership is fundamental to obtaining long-term strategic goals and is critical to the long-term future of the libraries. PMID:29632444

Research progress of asymptomatic bacteriuria before arthroplasty: A systematic review.

PubMed

Zhang, Qingyu; Liu, Lihua; Sun, Wei; Gao, Fuqiang; Cheng, Liming; Li, Zirong

2018-02-01

A high prevalence of asymptomatic bacteriuria exists in patients prior to arthroplasty, and urinary tract infection is considered to be a source of postoperative superficial wound and prosthetic joint infections. There is no consensus whether to screen for and treat asymptomatic bacteriuria before arthroplasty. To summarize the association between asymptomatic bacteriuria and complications after arthroplasty and to evaluate the clinical benefits of treating asymptomatic bacteriuria prior to arthroplasty. We systematically searched PubMed, Embase, and the Cochrane Library to retrieve potentially eligible articles. By screening the titles and abstracts of retrieved records and then reading the full texts of the remaining papers, we finally included 8 English-language articles in this systematic review. Asymptomatic bacteriuria prior to arthroplasty is significantly associated with an increased occurrence of postoperative prosthetic joint and superficial wound infections. However, there is little evidence for direct or hematogenous seeding of urinary infections, and treating asymptomatic bacteriuria before arthroplasty did not decrease the incidence of postoperative infectious complications. Asymptomatic bacteriuria is not a contraindication for arthroplasty, and the practice of routine preoperative screening for and treatment of asymptomatic bacteriuria should not be continued.

Trends in health sciences library and information science research: an analysis of research publications in the Bulletin of the Medical Library Association and Journal of the Medical Library Association from 1991 to 2007.

PubMed

Gore, Sally A; Nordberg, Judith M; Palmer, Lisa A; Piorun, Mary E

2009-07-01

This study analyzed trends in research activity as represented in the published research in the leading peer-reviewed professional journal for health sciences librarianship. Research articles were identified from the Bulletin of the Medical Library Association and Journal of the Medical Library Association (1991-2007). Using content analysis and bibliometric techniques, data were collected for each article on the (1) subject, (2) research method, (3) analytical technique used, (4) number of authors, (5) number of citations, (6) first author affiliation, and (7) funding source. The results were compared to a previous study, covering the period 1966 to 1990, to identify changes over time. Of the 930 articles examined, 474 (51%) were identified as research articles. Survey (n = 174, 37.1%) was the most common methodology employed, quantitative descriptive statistics (n = 298, 63.5%) the most used analytical technique, and applied topics (n = 332, 70%) the most common type of subject studied. The majority of first authors were associated with an academic health sciences library (n = 264, 55.7%). Only 27.4% (n = 130) of studies identified a funding source. This study's findings demonstrate that progress is being made in health sciences librarianship research. There is, however, room for improvement in terms of research methodologies used, proportion of applied versus theoretical research, and elimination of barriers to conducting research for practicing librarians.

Towards a high performance geometry library for particle-detector simulations

DOE PAGES

Apostolakis, J.; Bandieramonte, M.; Bitzes, G.; ...

2015-05-22

Thread-parallelization and single-instruction multiple data (SIMD) ”vectorisation” of software components in HEP computing has become a necessity to fully benefit from current and future computing hardware. In this context, the Geant-Vector/GPU simulation project aims to re-engineer current software for the simulation of the passage of particles through detectors in order to increase the overall event throughput. As one of the core modules in this area, the geometry library plays a central role and vectorising its algorithms will be one of the cornerstones towards achieving good CPU performance. Here, we report on the progress made in vectorising the shape primitives, asmore » well as in applying new C++ template based optimizations of existing code available in the Geant4, ROOT or USolids geometry libraries. We will focus on a presentation of our software development approach that aims to provide optimized code for all use cases of the library (e.g., single particle and many-particle APIs) and to support different architectures (CPU and GPU) while keeping the code base small, manageable and maintainable. We report on a generic and templated C++ geometry library as a continuation of the AIDA USolids project. As a result, the experience gained with these developments will be beneficial to other parts of the simulation software, such as for the optimization of the physics library, and possibly to other parts of the experiment software stack, such as reconstruction and analysis.« less

Towards a high performance geometry library for particle-detector simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Apostolakis, J.; Bandieramonte, M.; Bitzes, G.

Thread-parallelization and single-instruction multiple data (SIMD) ”vectorisation” of software components in HEP computing has become a necessity to fully benefit from current and future computing hardware. In this context, the Geant-Vector/GPU simulation project aims to re-engineer current software for the simulation of the passage of particles through detectors in order to increase the overall event throughput. As one of the core modules in this area, the geometry library plays a central role and vectorising its algorithms will be one of the cornerstones towards achieving good CPU performance. Here, we report on the progress made in vectorising the shape primitives, asmore » well as in applying new C++ template based optimizations of existing code available in the Geant4, ROOT or USolids geometry libraries. We will focus on a presentation of our software development approach that aims to provide optimized code for all use cases of the library (e.g., single particle and many-particle APIs) and to support different architectures (CPU and GPU) while keeping the code base small, manageable and maintainable. We report on a generic and templated C++ geometry library as a continuation of the AIDA USolids project. As a result, the experience gained with these developments will be beneficial to other parts of the simulation software, such as for the optimization of the physics library, and possibly to other parts of the experiment software stack, such as reconstruction and analysis.« less

Libraries and Librarians: Key Partners for Progress in Health Literacy Research and Practice.

PubMed

Whitney, Wanda; Keselman, Alla; Humphreys, Betsy

2017-01-01

The field of librarianship has a history of involvement in patient education, general literacy and information literacy efforts. This history and prominent placement in communities make libraries and librarians an excellent resource in advancing health literacy practice and research. This chapter provides an overview of health literacy and health information literacy efforts in US libraries over the past two decades. The chapter begins with the description of the role of the US National Library of Medicine in developing resources, programs, and partnerships serving health information needs of the public. It then overviews special training programs for increasing librarians' expertise with health information and health literacy support. The narrative also presents different models of health information outreach programs in diverse communities, focusing on serving special populations that may suffer from health disparities. The second half of the chapter describes libraries' and librarians' health information response to continuously evolving contexts, mediums, and requirements. One subsection describes librarians' outreach effort with cutting-edge technologies, such as virtual worlds and gaming. Another focuses on supporting patients' information needs in clinical settings. Two more describe how libraries meet patrons' health information needs in the context of disaster preparedness and health insurance market place sign-up. While presenting the information, to the extent possible, the chapter draws upon research and evaluation of the effectiveness of different types of programs. It also discusses enablers of successes, limitations of the existing data, and directions for future research.

Findings from the most recent Medical Library Association salary survey.

PubMed

Wallace, Marc; McMullen, Thomas D; Corcoran, Kate

2004-10-01

The objective is to provide information on basic issues in library management identified by the Medical Library Association's (MLA's) seventh triennial salary survey. The survey was a Web-based questionnaire. A nonrandom sample of persons was obtained by posting messages to MLA's membership and to the MEDLIB-L e-mail discussion list. Employed MLA members and nonmembers employed in medical library settings filled out a Web-based form designed using common gateway interface (CGI) programming. Six hundred forty-five usable responses were analyzed by the Hay Group and presented in the MLA publication, Hay Group/MLA 2001 Compensation and Benefits Survey. Results from the 2001 survey in this article focus on pay and job satisfaction. Salary survey results since 1983 were analyzed to review trends in seniority, diversity, and pay equity. Given the age progression of respondents from 1983 to 2001, it is clear that succession planning is a core issue for medical libraries. Although efforts to create more diversity in medical libraries in member organizations have started to yield results, pay for white respondents has increased at a higher rate than for other racial categories. The authors found that the pay-for-performance system in the organizations of approximately two-thirds of the respondents is suboptimized and that most of the reasons medical librarians cite for leaving their organization can be addressed and potentially changed by management. Results from the eighth salary survey, slated to be conducted in the fall of 2004, will further track these trends and issues.

[175 years of the National Library of Medicine, of the United States of America: a scientific and cultural treasure worthy of admiration].

PubMed

Cabello C, Felipe

2011-09-01

The National Library of Medicine (NLM) of the United States of America, celebrates in 2011 its 175th anniversary. This Library, the largest biomedical library in the world, has a proud and rich history serving the health community and the public, especially since its transfer to the National Institutes of Health in Bethesda, Maryland, in 1968. It holds 17 million publications in 150 languages, and has an important collection of ancient and modern historical books as well as original publications of Vesalius and other founders of biomedicine. Its modern document collections illustrate the progress of medical sciences. These collections include laboratory notes from many scientists whose work forms the foundations of contemporary life sciences. The Library also provides several services for health research and for the public, including databases and services such as MedLine and BLAST. The NLM constantly strives to fulfill the information needs of its customers, whether scientists or the public at large. For example, as the Hispanic population of the Unites States has increased in recent years, the NLM has made larger and larger amounts of data available in Spanish to fulfill the health information needs of this population. NLM programs train professionals in library science and biomedical informatics and link biomedical libraries of 18 academic centers throughout the United States. The NLM funds competitive grants for training at the Library, organizing short instruction courses about library science and informatics, and writing books on health related matters including the history of medicine and public health. The NLM is managed and maintained by an outstanding and farsighted group of professionals and dedicated support staff. Their focus on serving and reaching both the biomedical community and the public at large has been crucial to its development into a world icon of biomedical sciences, information technology and the humanities.

Strong spurious transcription likely contributes to DNA insert bias in typical metagenomic clone libraries.

PubMed

Lam, Kathy N; Charles, Trevor C

2015-01-01

Clone libraries provide researchers with a powerful resource to study nucleic acid from diverse sources. Metagenomic clone libraries in particular have aided in studies of microbial biodiversity and function, and allowed the mining of novel enzymes. Libraries are often constructed by cloning large inserts into cosmid or fosmid vectors. Recently, there have been reports of GC bias in fosmid metagenomic libraries, and it was speculated to be a result of fragmentation and loss of AT-rich sequences during cloning. However, evidence in the literature suggests that transcriptional activity or gene product toxicity may play a role. To explore possible mechanisms responsible for sequence bias in clone libraries, we constructed a cosmid library from a human microbiome sample and sequenced DNA from different steps during library construction: crude extract DNA, size-selected DNA, and cosmid library DNA. We confirmed a GC bias in the final cosmid library, and we provide evidence that the bias is not due to fragmentation and loss of AT-rich sequences but is likely occurring after DNA is introduced into Escherichia coli. To investigate the influence of strong constitutive transcription, we searched the sequence data for promoters and found that rpoD/σ(70) promoter sequences were underrepresented in the cosmid library. Furthermore, when we examined the genomes of taxa that were differentially abundant in the cosmid library relative to the original sample, we found the bias to be more correlated with the number of rpoD/σ(70) consensus sequences in the genome than with simple GC content. The GC bias of metagenomic libraries does not appear to be due to DNA fragmentation. Rather, analysis of promoter sequences provides support for the hypothesis that strong constitutive transcription from sequences recognized as rpoD/σ(70) consensus-like in E. coli may lead to instability, causing loss of the plasmid or loss of the insert DNA that gives rise to the transcription. Despite widespread use of E. coli to propagate foreign DNA in metagenomic libraries, the effects of in vivo transcriptional activity on clone stability are not well understood. Further work is required to tease apart the effects of transcription from those of gene product toxicity.

A part toolbox to tune genetic expression in Bacillus subtilis

PubMed Central

Guiziou, Sarah; Sauveplane, Vincent; Chang, Hung-Ju; Clerté, Caroline; Declerck, Nathalie; Jules, Matthieu; Bonnet, Jerome

2016-01-01

Libraries of well-characterised components regulating gene expression levels are essential to many synthetic biology applications. While widely available for the Gram-negative model bacterium Escherichia coli, such libraries are lacking for the Gram-positive model Bacillus subtilis, a key organism for basic research and biotechnological applications. Here, we engineered a genetic toolbox comprising libraries of promoters, Ribosome Binding Sites (RBS), and protein degradation tags to precisely tune gene expression in B. subtilis. We first designed a modular Expression Operating Unit (EOU) facilitating parts assembly and modifications and providing a standard genetic context for gene circuits implementation. We then selected native, constitutive promoters of B. subtilis and efficient RBS sequences from which we engineered three promoters and three RBS sequence libraries exhibiting ∼14 000-fold dynamic range in gene expression levels. We also designed a collection of SsrA proteolysis tags of variable strength. Finally, by using fluorescence fluctuation methods coupled with two-photon microscopy, we quantified the absolute concentration of GFP in a subset of strains from the library. Our complete promoters and RBS sequences library comprising over 135 constructs enables tuning of GFP concentration over five orders of magnitude, from 0.05 to 700 μM. This toolbox of regulatory components will support many research and engineering applications in B. subtilis. PMID:27402159

Systematic Biological Filter Design with a Desired I/O Filtering Response Based on Promoter-RBS Libraries.

PubMed

Hsu, Chih-Yuan; Pan, Zhen-Ming; Hu, Rei-Hsing; Chang, Chih-Chun; Cheng, Hsiao-Chun; Lin, Che; Chen, Bor-Sen

2015-01-01

In this study, robust biological filters with an external control to match a desired input/output (I/O) filtering response are engineered based on the well-characterized promoter-RBS libraries and a cascade gene circuit topology. In the field of synthetic biology, the biological filter system serves as a powerful detector or sensor to sense different molecular signals and produces a specific output response only if the concentration of the input molecular signal is higher or lower than a specified threshold. The proposed systematic design method of robust biological filters is summarized into three steps. Firstly, several well-characterized promoter-RBS libraries are established for biological filter design by identifying and collecting the quantitative and qualitative characteristics of their promoter-RBS components via nonlinear parameter estimation method. Then, the topology of synthetic biological filter is decomposed into three cascade gene regulatory modules, and an appropriate promoter-RBS library is selected for each module to achieve the desired I/O specification of a biological filter. Finally, based on the proposed systematic method, a robust externally tunable biological filter is engineered by searching the promoter-RBS component libraries and a control inducer concentration library to achieve the optimal reference match for the specified I/O filtering response.

In vitro selection using a dual RNA library that allows primerless selection

PubMed Central

Jarosch, Florian; Buchner, Klaus; Klussmann, Sven

2006-01-01

High affinity target-binding aptamers are identified from random oligonucleotide libraries by an in vitro selection process called Systematic Evolution of Ligands by EXponential enrichment (SELEX). Since the SELEX process includes a PCR amplification step the randomized region of the oligonucleotide libraries need to be flanked by two fixed primer binding sequences. These primer binding sites are often difficult to truncate because they may be necessary to maintain the structure of the aptamer or may even be part of the target binding motif. We designed a novel type of RNA library that carries fixed sequences which constrain the oligonucleotides into a partly double-stranded structure, thereby minimizing the risk that the primer binding sequences become part of the target-binding motif. Moreover, the specific design of the library including the use of tandem RNA Polymerase promoters allows the selection of oligonucleotides without any primer binding sequences. The library was used to select aptamers to the mirror-image peptide of ghrelin. Ghrelin is a potent stimulator of growth-hormone release and food intake. After selection, the identified aptamer sequences were directly synthesized in their mirror-image configuration. The final 44 nt-Spiegelmer, named NOX-B11-3, blocks ghrelin action in a cell culture assay displaying an IC50 of 4.5 nM at 37°C. PMID:16855281

Only for “purely scientific” institutions: the Medical Library Association's Exchange, 1898–1950s

PubMed Central

Connor, Jennifer J

2011-01-01

Objective: Centralized exchanges of scientific materials existed by the late nineteenth century, but they did not include medical publications. North American medical leaders therefore formed an association of institutions to run their own exchange: the Medical Library Association (MLA). After providing background to the exchange concept and the importance of institutional members for MLA, this article examines archival MLA correspondence to consider the role of its Exchange in the association's professional development before the 1950s. Results: MLA's membership policy admitted only libraries open to the medical profession with a large number of volumes. But the correspondence of the MLA Executive Committee reveals that the committee constantly adjusted the definition of library membership: personal, public, sectarian, commercial, allied science, and the then-termed “colored” medical school libraries all were denied membership. Conclusion: Study of these decisions, using commercial and sectarian libraries as a focus, uncovers the primary justification for membership exclusions: a goal of operating a scientific exchange. Also, it shows that in this way, MLA shadowed policies and actions of the American Medical Association. Finally, the study suggests that the medical profession enforced its policies of exclusion through MLA, despite a proclaimed altruistic sharing of medical literature. PMID:21464849

Library of Advanced Materials for Engineering (LAME) 4.44.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scherzinger, William M.; Lester, Brian T.

Accurate and efficient constitutive modeling remains a cornerstone issues for solid mechanics analysis. Over the years, the LAME advanced material model library has grown to address this challenge by implementing models capable of describing material systems spanning soft polymers to s ti ff ceramics including both isotropic and anisotropic responses. Inelastic behaviors including (visco) plasticity, damage, and fracture have all incorporated for use in various analyses. This multitude of options and flexibility, however, comes at the cost of many capabilities, features, and responses and the ensuing complexity in the resulting implementation. Therefore, to enhance confidence and enable the utilization ofmore » the LAME library in application, this effort seeks to document and verify the various models in the LAME library. Specifically, the broader strategy, organization, and interface of the library itself is first presented. The physical theory, numerical implementation, and user guide for a large set of models is then discussed. Importantly, a number of verification tests are performed with each model to not only have confidence in the model itself but also highlight some important response characteristics and features that may be of interest to end-users. Finally, in looking ahead to the future, approaches to add material models to this library and further expand the capabilities are presented.« less

Library of Advanced Materials for Engineering (LAME) 4.48.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scherzinger, William M.; Lester, Brian T.

Accurate and efficient constitutive modeling remains a cornerstone issues for solid mechanics analysis. Over the years, the LAME advanced material model library has grown to address this challenge by implement- ing models capable of describing material systems spanning soft polymers to stiff ceramics including both isotropic and anisotropic responses. Inelastic behaviors including (visco)plasticity, damage, and fracture have all incorporated for use in various analyses. This multitude of options and flexibility, however, comes at the cost of many capabilities, features, and responses and the ensuing complexity in the resulting imple- mentation. Therefore, to enhance confidence and enable the utilization of themore » LAME library in application, this effort seeks to document and verify the various models in the LAME library. Specifically, the broader strategy, organization, and interface of the library itself is first presented. The physical theory, numerical implementation, and user guide for a large set of models is then discussed. Importantly, a number of verifi- cation tests are performed with each model to not only have confidence in the model itself but also highlight some important response characteristics and features that may be of interest to end-users. Finally, in looking ahead to the future, approaches to add material models to this library and further expand the capabilities are presented.« less

a UV Spectral Library of Metal-Poor Massive Stars

NASA Astrophysics Data System (ADS)

Robert, Carmelle

1994-01-01

We propose to use the FOS to build a snapshot library of UV spectra of a sample of about 50 metal-poor massive stars located in the Magellanic Clouds. The majority of libraries already existing contains spectra of hot stars with chemical abundances close to solar. The high spectral resolution achieves with the FOS will be a major factor for the uniqueness of this new library. UV spectral libraries represent fundamental tools for the study of the massive star populations of young star-forming regions. Massive stars, which are impossible to identify directly in the optical-IR part of a composite spectrum, display on the other hand key signatures in the UV region. These signatures are mainly broad, metallicity dependent spectral features formed in the hot star winds. They require a high spectral resolution (of the order of 200-300 km/s) for an adequate study. A spectral library of metal-poor massive stars represents also a unique source of data for a stellar atmosphere analysis. Within less then 10 min we will obtain a high signal-to-noise ratio of at least 30. Finally, since short exposure times are possible, this proposal makes extremely good use of the capabilities of HST. We designed an observing strategy which yields a maximum scientific return at a minimum cost of spacecraft time.

Implementation of Web 2.0 services in academic, medical and research libraries: a scoping review.

PubMed

Gardois, Paolo; Colombi, Nicoletta; Grillo, Gaetano; Villanacci, Maria C

2012-06-01

Academic, medical and research libraries frequently implement Web 2.0 services for users. Several reports notwithstanding, characteristics and effectiveness of services are unclear. To find out: the Web 2.0 services implemented by medical, academic and research libraries; study designs, measures and types of data used in included articles to evaluate effectiveness; whether the identified body of literature is amenable to a systematic review of results. Scoping review mapping the literature on the topic. Searches were performed in 19 databases. research articles in English, Italian, German, French and Spanish (publication date ≥ 2006) about Web 2.0 services for final users implemented by academic, medical and research libraries. Reviewers' agreement was measured by Cohen's kappa. From a data set of 6461 articles, 255 (4%) were coded and analysed. Conferencing/chat/instant messaging, blogging, podcasts, social networking, wikis and aggregators were frequently examined. Services were mainly targeted at general academic users of English-speaking countries. Data prohibit a reliable estimate of the relative frequency of implemented Web 2.0 services. Case studies were the prevalent design. Most articles evaluated different outcomes using diverse assessment methodologies. A systematic review is recommended to assess the effectiveness of such services. © 2012 The authors. Health Information and Libraries Journal © 2012 Health Libraries Group.

Comparing published scientific journal articles to their pre-print versions

DOE PAGES

Klein, Martin; Broadwell, Peter; Farb, Sharon E.; ...

2018-02-05

Academic publishers claim that they add value to scholarly communications by coordinating reviews and contributing and enhancing text during publication. These contributions come at a considerable cost: US academic libraries paid $1.7 billion for serial subscriptions in 2008 alone. Library budgets, in contrast, are flat and not able to keep pace with serial price inflation. Here, we have investigated the publishers’ value proposition by conducting a comparative study of pre-print papers from two distinct science, technology, and medicine corpora and their final published counterparts. This comparison had two working assumptions: (1) If the publishers’ argument is valid, the text ofmore » a pre-print paper should vary measurably from its corresponding final published version, and (2) by applying standard similarity measures, we should be able to detect and quantify such differences. Our analysis revealed that the text contents of the scientific papers generally changed very little from their pre-print to final published versions. These findings contribute empirical indicators to discussions of the added value of commercial publishers and therefore should influence libraries’ economic decisions regarding access to scholarly publications.« less

Comparing published scientific journal articles to their pre-print versions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klein, Martin; Broadwell, Peter; Farb, Sharon E.

Academic publishers claim that they add value to scholarly communications by coordinating reviews and contributing and enhancing text during publication. These contributions come at a considerable cost: US academic libraries paid $1.7 billion for serial subscriptions in 2008 alone. Library budgets, in contrast, are flat and not able to keep pace with serial price inflation. Here, we have investigated the publishers’ value proposition by conducting a comparative study of pre-print papers from two distinct science, technology, and medicine corpora and their final published counterparts. This comparison had two working assumptions: (1) If the publishers’ argument is valid, the text ofmore » a pre-print paper should vary measurably from its corresponding final published version, and (2) by applying standard similarity measures, we should be able to detect and quantify such differences. Our analysis revealed that the text contents of the scientific papers generally changed very little from their pre-print to final published versions. These findings contribute empirical indicators to discussions of the added value of commercial publishers and therefore should influence libraries’ economic decisions regarding access to scholarly publications.« less

ICT and Information Strategies for a Knowledge Economy: The Indian Experience

ERIC Educational Resources Information Center

Ghosh, Maitrayee; Ghosh, Ipsheet

2009-01-01

Purpose: The purpose of this paper is to describe the progress India has made in its move towards a knowledge-based economy with details of how the Indian Government has demonstrated its commitment to the development of fundamental pillars of knowledge sharing infrastructure, knowledge workers and a knowledge innovation system. Libraries are…

Document Image Processing: Going beyond the Black-and-White Barrier. Progress, Issues and Options with Greyscale and Colour Image Processing.

ERIC Educational Resources Information Center

Hendley, Tom

1995-01-01

Discussion of digital document image processing focuses on issues and options associated with greyscale and color image processing. Topics include speed; size of original document; scanning resolution; markets for different categories of scanners, including photographic libraries, publishing, and office applications; hybrid systems; data…

75 FR 80420 - Reasonable Further Progress Requirements for the 1997 8-Hour Ozone National Ambient Air Quality...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-22

... Air and Radiation Docket and Information Center is in the EPA Headquarters Library, Room Number 3334... hold a public hearing. Please refer to SUPPLEMENTARY INFORMATION for additional information on the... Information Center, Attention Docket ID No. EPA-HQ-OAR-2010-0891, Environmental Protection Agency, 1301...

Rare and Precious Books and Documents Section. Collections and Services Division. Papers.

ERIC Educational Resources Information Center

International Federation of Library Associations, The Hague (Netherlands).

Papers on rare and precious books and documents, which were presented at the 1983 International Federation of Library Associations (IFLA) conference, include: (1) "Report on the State of Work on the Union Catalogue of Incunabula (GW) and Progress in the International Cataloguing of Incunabula" by Ursula Altmann (East Germany); (2)…

University and Polytechnic Objectives, Resource Allocation and Performance Indices in the Central Services. Program on Institutional Management in Higher Education.

ERIC Educational Resources Information Center

Norris, Graeme, Ed.

Research progress by member institutions is reviewed with regard to university administration, computing, committees, libraries, and student welfare. Consideration is given to effectiveness and efficiency, management information, management by objectives, periodic review of objectives, strategy, and analytic resource allocation. Two research…

Naughty or Not? : Exploring Controversial Content and Core Universal Themes in Contemporary Young Adult Literature

ERIC Educational Resources Information Center

O'Bannion, Colette Marie

2010-01-01

A reader might assume contemporary society has progressed beyond literary censorship. However, as recently as 2008, the "Gossip Girl" and "Twilight" young adult literature series both faced challenges in distinct sectors of United States society (American Library Association (ALA), 2009: Martindale, 2008). A number of concerned…

The U.S. EPA ToxCast Program: Moving from Data Generation to Application (SOT Tox21 update symposium presentation)

EPA Science Inventory

The U.S. EPA ToxCast program is entering its tenth year. Significant learning and progress have occurred towards collection, analysis, and interpretation of the data. The library of ~1,800 chemicals has been subject to ongoing characterization (e.g., identity, purity, stability...

Plan for Progress in the Media Center; 7-12.

ERIC Educational Resources Information Center

Iowa State Dept. of Public Instruction, Des Moines.

This handbook has been prepared by a committee composed of administrators and media specialists under the direction of the Department of Public Instruction. Its purpose is to establish guidelines for media centers in the secondary schools of Iowa. Most secondary schools in Iowa now have traditional libraries. This handbook provides guidelines for…

User Instructions for the Final Version of the EPIC Research Code

DTIC Science & Technology

1996-04-01

by which library fracture strain constants (D1, D2, EFMIN- defined later) are multiplied. DFRAC = 1.0 will provide the exact library constants. EFAIL ...If EFAIL > 999, the check for total failure will be omitted. Deription Card for Solids Input Data (415, aX F5.0, A50) - This card (plus five additional...hydrostatic pressure capability remains. Can be used only with DAM 1. T142M 57 0 0 0 0 0 0 0 0 0 EFAIL - Equivalent plastic strain, or volumetric strain

Havery Mudd 2014-2015 Computer Science Conduit Clinic Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aspesi, G; Bai, J; Deese, R

2015-05-12

Conduit, a new open-source library developed at Lawrence Livermore National Laboratories, provides a C++ application programming interface (API) to describe and access scientific data. Conduit’s primary use is for inmemory data exchange in high performance computing (HPC) applications. Our team tested and improved Conduit to make it more appealing to potential adopters in the HPC community. We extended Conduit’s capabilities by prototyping four libraries: one for parallel communication using MPI, one for I/O functionality, one for aggregating performance data, and one for data visualization.

The effects of nuclear data library processing on Geant4 and MCNP simulations of the thermal neutron scattering law

NASA Astrophysics Data System (ADS)

Hartling, K.; Ciungu, B.; Li, G.; Bentoumi, G.; Sur, B.

2018-05-01

Monte Carlo codes such as MCNP and Geant4 rely on a combination of physics models and evaluated nuclear data files (ENDF) to simulate the transport of neutrons through various materials and geometries. The grid representation used to represent the final-state scattering energies and angles associated with neutron scattering interactions can significantly affect the predictions of these codes. In particular, the default thermal scattering libraries used by MCNP6.1 and Geant4.10.3 do not accurately reproduce the ENDF/B-VII.1 model in simulations of the double-differential cross section for thermal neutrons interacting with hydrogen nuclei in a thin layer of water. However, agreement between model and simulation can be achieved within the statistical error by re-processing ENDF/B-VII.I thermal scattering libraries with the NJOY code. The structure of the thermal scattering libraries and sampling algorithms in MCNP and Geant4 are also reviewed.

Shuffle Optimizer: A Program to Optimize DNA Shuffling for Protein Engineering.

PubMed

Milligan, John N; Garry, Daniel J

2017-01-01

DNA shuffling is a powerful tool to develop libraries of variants for protein engineering. Here, we present a protocol to use our freely available and easy-to-use computer program, Shuffle Optimizer. Shuffle Optimizer is written in the Python computer language and increases the nucleotide homology between two pieces of DNA desired to be shuffled together without changing the amino acid sequence. In addition we also include sections on optimal primer design for DNA shuffling and library construction, a small-volume ultrasonicator method to create sheared DNA, and finally a method to reassemble the sheared fragments and recover and clone the library. The Shuffle Optimizer program and these protocols will be useful to anyone desiring to perform any of the nucleotide homology-dependent shuffling methods.

Quantum mechanical energy-based screening of combinatorially generated library of tautomers. TauTGen: a tautomer generator program.

PubMed

Harańczyk, Maciej; Gutowski, Maciej

2007-01-01

We describe a procedure of finding low-energy tautomers of a molecule. The procedure consists of (i) combinatorial generation of a library of tautomers, (ii) screening based on the results of geometry optimization of initial structures performed at the density functional level of theory, and (iii) final refinement of geometry for the top hits at the second-order Möller-Plesset level of theory followed by single-point energy calculations at the coupled cluster level of theory with single, double, and perturbative triple excitations. The library of initial structures of various tautomers is generated with TauTGen, a tautomer generator program. The procedure proved to be successful for these molecular systems for which common chemical knowledge had not been sufficient to predict the most stable structures.

Teko: A block preconditioning capability with concrete example applications in Navier--Stokes and MHD

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cyr, Eric C.; Shadid, John N.; Tuminaro, Raymond S.

This study describes the design of Teko, an object-oriented C++ library for implementing advanced block preconditioners. Mathematical design criteria that elucidate the needs of block preconditioning libraries and techniques are explained and shown to motivate the structure of Teko. For instance, a principal design choice was for Teko to strongly reflect the mathematical statement of the preconditioners to reduce development burden and permit focus on the numerics. Additional mechanisms are explained that provide a pathway to developing an optimized production capable block preconditioning capability with Teko. Finally, Teko is demonstrated on fluid flow and magnetohydrodynamics applications. In addition to highlightingmore » the features of the Teko library, these new results illustrate the effectiveness of recent preconditioning developments applied to advanced discretization approaches.« less

Teko: A block preconditioning capability with concrete example applications in Navier--Stokes and MHD

DOE PAGES

Cyr, Eric C.; Shadid, John N.; Tuminaro, Raymond S.

2016-10-27

This study describes the design of Teko, an object-oriented C++ library for implementing advanced block preconditioners. Mathematical design criteria that elucidate the needs of block preconditioning libraries and techniques are explained and shown to motivate the structure of Teko. For instance, a principal design choice was for Teko to strongly reflect the mathematical statement of the preconditioners to reduce development burden and permit focus on the numerics. Additional mechanisms are explained that provide a pathway to developing an optimized production capable block preconditioning capability with Teko. Finally, Teko is demonstrated on fluid flow and magnetohydrodynamics applications. In addition to highlightingmore » the features of the Teko library, these new results illustrate the effectiveness of recent preconditioning developments applied to advanced discretization approaches.« less

Final Progress Report for Ionospheric Dusty Plasma In the Laboratory [Smokey Plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robertson, Scott

2010-07-31

“Ionospheric Dusty Plasma in the Laboratory” is a research project with the purpose of finding and reproducing the characteristics of plasma in the polar mesosphere that is unusually cold (down to 140 K) and contains nanometer-sized dust particles. This final progress report summarizes results from four years of effort that include a final year with a no-cost extension.

Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep).

PubMed

Guellouz, Asma; Valerio-Lepiniec, Marie; Urvoas, Agathe; Chevrel, Anne; Graille, Marc; Fourati-Kammoun, Zaineb; Desmadril, Michel; van Tilbeurgh, Herman; Minard, Philippe

2013-01-01

We previously designed a new family of artificial proteins named αRep based on a subgroup of thermostable helicoidal HEAT-like repeats. We have now assembled a large optimized αRep library. In this library, the side chains at each variable position are not fully randomized but instead encoded by a distribution of codons based on the natural frequency of side chains of the natural repeats family. The library construction is based on a polymerization of micro-genes and therefore results in a distribution of proteins with a variable number of repeats. We improved the library construction process using a "filtration" procedure to retain only fully coding modules that were recombined to recreate sequence diversity. The final library named Lib2.1 contains 1.7×10(9) independent clones. Here, we used phage display to select, from the previously described library or from the new library, new specific αRep proteins binding to four different non-related predefined protein targets. Specific binders were selected in each case. The results show that binders with various sizes are selected including relatively long sequences, with up to 7 repeats. ITC-measured affinities vary with Kd values ranging from micromolar to nanomolar ranges. The formation of complexes is associated with a significant thermal stabilization of the bound target protein. The crystal structures of two complexes between αRep and their cognate targets were solved and show that the new interfaces are established by the variable surfaces of the repeated modules, as well by the variable N-cap residues. These results suggest that αRep library is a new and versatile source of tight and specific binding proteins with favorable biophysical properties.

Development of a large peptoid-DOTA combinatorial library.

PubMed

Singh, Jaspal; Lopes, Daniel; Gomika Udugamasooriya, D

2016-09-01

Conventional one-bead one-compound (OBOC) library synthesis is typically used to identify molecules with therapeutic value. The design and synthesis of OBOC libraries that contain molecules with imaging or even potentially therapeutic and diagnostic capacities (e.g. theranostic agents) has been overlooked. The development of a therapeutically active molecule with a built-in imaging component for a certain target is a daunting task, and structure-based rational design might not be the best approach. We hypothesize to develop a combinatorial library with potentially therapeutic and imaging components fused together in each molecule. Such molecules in the library can be used to screen, identify, and validate as direct theranostic candidates against targets of interest. As the first step in achieving that aim, we developed an on-bead library of 153,600 Peptoid-DOTA compounds in which the peptoids are the target-recognizing and potentially therapeutic components and the DOTA is the imaging component. We attached the DOTA scaffold to TentaGel beads using one of the four arms of DOTA, and we built a diversified 6-mer peptoid library on the remaining three arms. We evaluated both the synthesis and the mass spectrometric sequencing capacities of the test compounds and of the final library. The compounds displayed unique ionization patterns including direct breakages of the DOTA scaffold into two units, allowing clear decoding of the sequences. Our approach provides a facile synthesis method for the complete on-bead development of large peptidomimetic-DOTA libraries for screening against biological targets for the identification of potential theranostic agents in the future. © 2016 The Authors. Biopolymers Published by Wiley Periodicals, Inc. Biopolymers (Pept Sci) 106: 673-684, 2016. © 2016 The Authors. Biopolymers Published by Wiley Periodicals, Inc.

Selection of Specific Protein Binders for Pre-Defined Targets from an Optimized Library of Artificial Helicoidal Repeat Proteins (alphaRep)

PubMed Central

Chevrel, Anne; Graille, Marc; Fourati-Kammoun, Zaineb; Desmadril, Michel; van Tilbeurgh, Herman; Minard, Philippe

2013-01-01

We previously designed a new family of artificial proteins named αRep based on a subgroup of thermostable helicoidal HEAT-like repeats. We have now assembled a large optimized αRep library. In this library, the side chains at each variable position are not fully randomized but instead encoded by a distribution of codons based on the natural frequency of side chains of the natural repeats family. The library construction is based on a polymerization of micro-genes and therefore results in a distribution of proteins with a variable number of repeats. We improved the library construction process using a “filtration” procedure to retain only fully coding modules that were recombined to recreate sequence diversity. The final library named Lib2.1 contains 1.7×109 independent clones. Here, we used phage display to select, from the previously described library or from the new library, new specific αRep proteins binding to four different non-related predefined protein targets. Specific binders were selected in each case. The results show that binders with various sizes are selected including relatively long sequences, with up to 7 repeats. ITC-measured affinities vary with Kd values ranging from micromolar to nanomolar ranges. The formation of complexes is associated with a significant thermal stabilization of the bound target protein. The crystal structures of two complexes between αRep and their cognate targets were solved and show that the new interfaces are established by the variable surfaces of the repeated modules, as well by the variable N-cap residues. These results suggest that αRep library is a new and versatile source of tight and specific binding proteins with favorable biophysical properties. PMID:24014183

Next-Generation DNA Sequencing of VH/VL Repertoires: A Primer and Guide to Applications in Single-Domain Antibody Discovery.

PubMed

Henry, Kevin A

2018-01-01

Immunogenetic analyses of expressed antibody repertoires are becoming increasingly common experimental investigations and are critical to furthering our understanding of autoimmunity, infectious disease, and cancer. Next-generation DNA sequencing (NGS) technologies have now made it possible to interrogate antibody repertoires to unprecedented depths, typically by sequencing of cDNAs encoding immunoglobulin variable domains. In this chapter, we describe simple, fast, and reliable methods for producing and sequencing multiplex PCR amplicons derived from the variable regions (V H , V H H or V L ) of rearranged immunoglobulin heavy and light chain genes using the Illumina MiSeq platform. We include complete protocols and primer sets for amplicon sequencing of V H /V H H/V L repertoires directly from human, mouse, and llama lymphocytes as well as from phage-displayed V H /V H H/V L libraries; these can be easily be adapted to other types of amplicons with little modification. The resulting amplicons are diverse and representative, even using as few as 10 3 input B cells, and their generation is relatively inexpensive, requiring no special equipment and only a limited set of primers. In the absence of heavy-light chain pairing, single-domain antibodies are uniquely amenable to NGS analyses. We present a number of applications of NGS technology useful in discovery of single-domain antibodies from phage display libraries, including: (i) assessment of library functionality; (ii) confirmation of desired library randomization; (iii) estimation of library diversity; and (iv) monitoring the progress of panning experiments. While the case studies presented here are of phage-displayed single-domain antibody libraries, the principles extend to other types of in vitro display libraries.

Template-based structure modeling of protein-protein interactions

PubMed Central

Szilagyi, Andras; Zhang, Yang

2014-01-01

The structure of protein-protein complexes can be constructed by using the known structure of other protein complexes as a template. The complex structure templates are generally detected either by homology-based sequence alignments or, given the structure of monomer components, by structure-based comparisons. Critical improvements have been made in recent years by utilizing interface recognition and by recombining monomer and complex template libraries. Encouraging progress has also been witnessed in genome-wide applications of template-based modeling, with modeling accuracy comparable to high-throughput experimental data. Nevertheless, bottlenecks exist due to the incompleteness of the proteinprotein complex structure library and the lack of methods for distant homologous template identification and full-length complex structure refinement. PMID:24721449

Report on accreditation learning sets in the West Midlands region of the NHS.

PubMed

Giles, G

2000-12-01

This article reports on the evaluation of the first year of a project, which utilized learning sets to support librarians undergoing the accreditation process, in the health libraries in the West Midlands region of the NHS. The West Midlands Health region is divided up into education consortia patches. Each group of patch librarians was allocated a local accreditation facilitator. The groups met regularly to discuss problems and progress relating to their library's accreditation. The results of the evaluation suggest that this is a valuable approach to use. The recommendations state that regular, frequent meetings are needed. Extra training and guidance would help the facilitators to be more effective in their role.

Preservation of the biomedical literature: an overview.

PubMed Central

Byrnes, M M

1989-01-01

The National Library of Medicine began to preserve its collection many years ago. This article presents a brief review of NLM's early conservation and microfilming programs, and describes the current activities of the library's new Preservation Section. Also mentioned are the complementary efforts of NLM staff who are involved in research into electronic imaging and the campaign to increase the use of alkaline paper in medical and scientific publishing. Goals of the National Preservation Plan for the Biomedical Literature are summarized and a report on progress in implementing the plan is provided. Results of the preservation needs assessment described in the accompanying article by Kirkpatrick are briefly analyzed. Recent efforts of the Commission on Preservation and Access, the National Endowment for the Humanities, the Research Libraries Group, and several international associations are described in terms of their potential benefit to preservation of the biomedical literature. The need to monitor new preservation technologies and preserve materials in audiovisual and electronic formats is emphasized. It is argued that with enough coordination, cooperation, and willingness among health sciences libraries to share the costs, the goal of preserving all of the important biomedical literature can be accomplished. PMID:2758180

Automation and hypermedia technology applications

NASA Technical Reports Server (NTRS)

Jupin, Joseph H.; Ng, Edward W.; James, Mark L.

1993-01-01

This paper represents a progress report on HyLite (Hypermedia Library technology): a research and development activity to produce a versatile system as part of NASA's technology thrusts in automation, information sciences, and communications. HyLite can be used as a system or tool to facilitate the creation and maintenance of large distributed electronic libraries. The contents of such a library may be software components, hardware parts or designs, scientific data sets or databases, configuration management information, etc. Proliferation of computer use has made the diversity and quantity of information too large for any single user to sort, process, and utilize effectively. In response to this information deluge, we have created HyLite to enable the user to process relevant information into a more efficient organization for presentation, retrieval, and readability. To accomplish this end, we have incorporated various AI techniques into the HyLite hypermedia engine to facilitate parameters and properties of the system. The proposed techniques include intelligent searching tools for the libraries, intelligent retrievals, and navigational assistance based on user histories. HyLite itself is based on an earlier project, the Encyclopedia of Software Components (ESC) which used hypermedia to facilitate and encourage software reuse.

X-ray Pulsars Across the Parameter Space of Luminosity, Accretion Mode, and Spin

NASA Astrophysics Data System (ADS)

Laycock, Silas; Yang, Jun; Christodoulou, Dimitris; Coe, Malcolm; Cappallo, Rigel; Zezas, Andreas; Ho, Wynn C. G.; Hong, JaeSub; Fingerman, Samuel; Drake, Jeremy J.; Kretschmar, Peter; Antoniou, Vallia

2017-08-01

We present our multi-satellite library of X-ray Pulsar observations to the community, and highlight recent science results. Available at www.xraypulsars.space the library provides a range of high-level data products, including: activity histories, pulse-profiles, phased event files, and a unique pulse-profile modeling interface. The initial release (v1.0) contains some 15 years of RXTE-PCA, Chandra ACIS-I, and XMM-PN observations of the Small Magellanic Cloud, creating a valuable record of pulsar behavior. Our library is intended to enable new progress on fundamental NS parameters and accretion physics. The major motivations are (1) Assemble a large homogeneous sample to enable population statistics. This has so far been used to map the propeller transition, and explore the role of retrograde and pro-grade accretion disks. (2) Obtain pulse-profiles for the same pulsars on many different occasions, at different luminosities and states in order to break model degeneracies. This effort has led to preliminary measurements of the offsets between magnetic and spin axes. With the addition of other satellites, and Galactic pulsars, the library will cover the entire available range of luminosity, variability timescales and accretion regimes.

Discovering Drugs with DNA-Encoded Library Technology: From Concept to Clinic with an Inhibitor of Soluble Epoxide Hydrolase.

PubMed

Belyanskaya, Svetlana L; Ding, Yun; Callahan, James F; Lazaar, Aili L; Israel, David I

2017-05-04

DNA-encoded chemical library technology was developed with the vision of its becoming a transformational platform for drug discovery. The hope was that a new paradigm for the discovery of low-molecular-weight drugs would be enabled by combining the vast molecular diversity achievable with combinatorial chemistry, the information-encoding attributes of DNA, the power of molecular biology, and a streamlined selection-based discovery process. Here, we describe the discovery and early clinical development of GSK2256294, an inhibitor of soluble epoxide hydrolase (sEH, EPHX2), by using encoded-library technology (ELT). GSK2256294 is an orally bioavailable, potent and selective inhibitor of sEH that has a long half life and produced no serious adverse events in a first-time-in-human clinical study. To our knowledge, GSK2256294 is the first molecule discovered from this technology to enter human clinical testing and represents a realization of the vision that DNA-encoded chemical library technology can efficiently yield molecules with favorable properties that can be readily progressed into high-quality drugs. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Recommendations of the Commission on Government Procurement: A Final Assessment

DTIC Science & Technology

1979-05-31

Assessment TECHNICAi; LIBRARY Important structural changes are now in place on procurement reforms first proposed in 1972, but the program is far...COMPTROLLER GENERAL’S REPORT TO THE CONGRESS RECOMMENDATIONS OF THE COMMISSION ON GOVERNMENT PROCUREMENT: A FINAL ASSESSMENT DIGEST As Federal...legislation and —the Office of Federal Procurement Policy (OFPP) to lead in making needed changes. OVERALL ASSESSMENT Success of the reform program is still

Final Report of the Ad Hoc Subcommittee on Subject Analysis of African and Asian Materials. Subject Analysis Committee, Cataloging and Classification Section, Resources and Technical Services Division, ALA.

ERIC Educational Resources Information Center

Zuckerman, Arline; And Others

Six general recommendations reflect the findings from this final report on subject analysis of African and Asian library materials: (1) more specificity of headings, especially subdivisions and unique terms, are needed; (2) more attention should be given to Asian and African materials, using available expertise; (3) efforts to eliminate offensive…

A large shRNA library approach identifies lncRNA Ntep as an essential regulator of cell proliferation

PubMed Central

Beermann, Julia; Kirste, Dominique; Iwanov, Katharina; Lu, Dongchao; Kleemiß, Felix; Kumarswamy, Regalla; Schimmel, Katharina; Bär, Christian; Thum, Thomas

2018-01-01

The mammalian cell cycle is a complex and tightly controlled event. Myriads of different control mechanisms are involved in its regulation. Long non-coding RNAs (lncRNA) have emerged as important regulators of many cellular processes including cellular proliferation. However, a more global and unbiased approach to identify lncRNAs with importance for cell proliferation is missing. Here, we present a lentiviral shRNA library-based approach for functional lncRNA profiling. We validated our library approach in NIH3T3 (3T3) fibroblasts by identifying lncRNAs critically involved in cell proliferation. Using stringent selection criteria we identified lncRNA NR_015491.1 out of 3842 different RNA targets represented in our library. We termed this transcript Ntep (non-coding transcript essential for proliferation), as a bona fide lncRNA essential for cell cycle progression. Inhibition of Ntep in 3T3 and primary fibroblasts prevented normal cell growth and expression of key fibroblast markers. Mechanistically, we discovered that Ntep is important to activate P53 concomitant with increased apoptosis and cell cycle blockade in late G2/M. Our findings suggest Ntep to serve as an important regulator of fibroblast proliferation and function. In summary, our study demonstrates the applicability of an innovative shRNA library approach to identify long non-coding RNA functions in a massive parallel approach. PMID:29099486

A standard stellar library for evolutionary synthesis. III. Metallicity calibration

NASA Astrophysics Data System (ADS)

Westera, P.; Lejeune, T.; Buser, R.; Cuisinier, F.; Bruzual, G.

2002-01-01

We extend the colour calibration of the widely used BaSeL standard stellar library (Lejeune et al. 1997, 1998) to non-solar metallicities, down to [Fe/H] ~ -2.0 dex. Surprisingly, we find that at the present epoch it is virtually impossible to establish a unique calibration of UBVRIJHKL colours in terms of stellar metallicity [Fe/H] which is consistent simultaneously with both colour-temperature relations and colour-absolute magnitude diagrams (CMDs) based on observed globular cluster photometry data and on published, currently popular standard stellar evolutionary tracks and isochrones. The problem appears to be related to the long-standing incompleteness in our understanding of convection in late-type stellar evolution, but is also due to a serious lack of relevant observational calibration data that would help resolve, or at least further significant progress towards resolving this issue. In view of the most important applications of the BaSeL library, we here propose two different metallicity calibration versions: (1) the ``WLBC 99'' library, which consistently matches empirical colour-temperature relations and which, therefore, should make an ideal tool for the study of individual stars; and (2), the ``PADOVA 2000'' library, which provides isochrones from the Padova 2000 grid (Girardi et al. \\cite{padova}) that successfully reproduce Galactic globular-cluster colour-absolute magnitude diagrams and which thus should prove particularly useful for studies of collective phenomena in stellar populations in clusters and galaxies.

From the ORFeome concept to highly comprehensive, full-genome screening libraries.

PubMed

Rid, Raphaela; Abdel-Hadi, Omar; Maier, Richard; Wagner, Martin; Hundsberger, Harald; Hintner, Helmut; Bauer, Johann; Onder, Kamil

2013-02-01

Recombination-based cloning techniques have in recent times facilitated the establishment of genome-scale single-gene ORFeome repositories. Their further handling and downstream application in systematic fashion is, however, practically impeded because of logistical plus economic challenges. At this juncture, simultaneously transferring entire gene collections in compiled pool format could represent an advanced compromise between systematic ORFeome (an organism's entire set of protein-encoding open reading frames) projects and traditional random library approaches, but has not yet been considered in great detail. In our endeavor to merge the comprehensiveness of ORFeomes with a basically simple, streamlined, and easily executable single-tube design, we have here produced five different pooled screening-ready libraries for both Staphylococcus aureus and Homo sapiens. By evaluating the parallel transfer efficiencies of differentially sized genes from initial polymerase chain reaction (PCR) product amplification to entry and final destination library construction via quantitative real-time PCR, we found that the complexity of the gene population is fairly stably maintained once an entry resource has been successfully established, and that no apparent size-selection bias loss of large inserts takes place. Recombinational transfer processes are hence robust enough for straightforwardly achieving such pooled screening libraries.

PSI-Center Final Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jarboe, Thomas R.; Shumlak, Uri; Sovinec, Carl

This is the Final Progress Report of the Plasma Science and Innovation Center (PSI-Center) covering March 2014 through February 2017. The Center has accomplished a great deal during this period. The PSI-Center is organized into four groups: Edge and Dynamic Neutrals; Transport and Kinetic Effects; Equilibrium, Stability, and Kinetic Effects in 3D Topologies; and Interface for Validation. Each group has made good progress and the results from each group are given in detail.

32 CFR 299.3 - Policy.

Code of Federal Regulations, 2012 CFR

2012-07-01

... does not originate final orders, opinions, statements of policy, interpretations, staff manuals, or... Cryptologic Museum (NCM), which serves as the NSA/CSS FOIA reading room, and made available through the... available in hard copy in the museum library and on the Internet. ...

32 CFR 299.3 - Policy.

Code of Federal Regulations, 2014 CFR

2014-07-01

... does not originate final orders, opinions, statements of policy, interpretations, staff manuals, or... Cryptologic Museum (NCM), which serves as the NSA/CSS FOIA reading room, and made available through the... available in hard copy in the museum library and on the Internet. ...

32 CFR 299.3 - Policy.

Code of Federal Regulations, 2011 CFR

2011-07-01

... does not originate final orders, opinions, statements of policy, interpretations, staff manuals, or... Cryptologic Museum (NCM), which serves as the NSA/CSS FOIA reading room, and made available through the... available in hard copy in the museum library and on the Internet. ...

32 CFR 299.3 - Policy.

Code of Federal Regulations, 2013 CFR

2013-07-01

... does not originate final orders, opinions, statements of policy, interpretations, staff manuals, or... Cryptologic Museum (NCM), which serves as the NSA/CSS FOIA reading room, and made available through the... available in hard copy in the museum library and on the Internet. ...

32 CFR 299.3 - Policy.

Code of Federal Regulations, 2010 CFR

2010-07-01

... does not originate final orders, opinions, statements of policy, interpretations, staff manuals, or... Cryptologic Museum (NCM), which serves as the NSA/CSS FOIA reading room, and made available through the... available in hard copy in the museum library and on the Internet. ...

PandaEPL: a library for programming spatial navigation experiments.

PubMed

Solway, Alec; Miller, Jonathan F; Kahana, Michael J

2013-12-01

Recent advances in neuroimaging and neural recording techniques have enabled researchers to make significant progress in understanding the neural mechanisms underlying human spatial navigation. Because these techniques generally require participants to remain stationary, computer-generated virtual environments are used. We introduce PandaEPL, a programming library for the Python language designed to simplify the creation of computer-controlled spatial-navigation experiments. PandaEPL is built on top of Panda3D, a modern open-source game engine. It allows users to construct three-dimensional environments that participants can navigate from a first-person perspective. Sound playback and recording and also joystick support are provided through the use of additional optional libraries. PandaEPL also handles many tasks common to all cognitive experiments, including managing configuration files, logging all internal and participant-generated events, and keeping track of the experiment state. We describe how PandaEPL compares with other software for building spatial-navigation experiments and walk the reader through the process of creating a fully functional experiment.

PandaEPL: A library for programming spatial navigation experiments

PubMed Central

Solway, Alec; Miller, Jonathan F.

2013-01-01

Recent advances in neuroimaging and neural recording techniques have enabled researchers to make significant progress in understanding the neural mechanisms underlying human spatial navigation. Because these techniques generally require participants to remain stationary, computer-generated virtual environments are used. We introduce PandaEPL, a programming library for the Python language designed to simplify the creation of computer-controlled spatial-navigation experiments. PandaEPL is built on top of Panda3D, a modern open-source game engine. It allows users to construct three-dimensional environments that participants can navigate from a first-person perspective. Sound playback and recording and also joystick support are provided through the use of additional optional libraries. PandaEPL also handles many tasks common to all cognitive experiments, including managing configuration files, logging all internal and participant-generated events, and keeping track of the experiment state. We describe how PandaEPL compares with other software for building spatial-navigation experiments and walk the reader through the process of creating a fully functional experiment. PMID:23549683

Trends in health sciences library and information science research: an analysis of research publications in the Bulletin of the Medical Library Association and Journal of the Medical Library Association from 1991 to 2007*

PubMed Central

Gore, Sally A.; Nordberg, Judith M.; Palmer, Lisa A.

2009-01-01

Objective: This study analyzed trends in research activity as represented in the published research in the leading peer-reviewed professional journal for health sciences librarianship. Methodology: Research articles were identified from the Bulletin of the Medical Library Association and Journal of the Medical Library Association (1991–2007). Using content analysis and bibliometric techniques, data were collected for each article on the (1) subject, (2) research method, (3) analytical technique used, (4) number of authors, (5) number of citations, (6) first author affiliation, and (7) funding source. The results were compared to a previous study, covering the period 1966 to 1990, to identify changes over time. Results: Of the 930 articles examined, 474 (51%) were identified as research articles. Survey (n = 174, 37.1%) was the most common methodology employed, quantitative descriptive statistics (n = 298, 63.5%) the most used analytical technique, and applied topics (n = 332, 70%) the most common type of subject studied. The majority of first authors were associated with an academic health sciences library (n = 264, 55.7%). Only 27.4% (n = 130) of studies identified a funding source. Conclusion: This study's findings demonstrate that progress is being made in health sciences librarianship research. There is, however, room for improvement in terms of research methodologies used, proportion of applied versus theoretical research, and elimination of barriers to conducting research for practicing librarians. PMID:19626146

The EULAR Outcome Measures Library: development and an example from a systematic review for systemic lupus erythematous instruments.

PubMed

Castrejon, I; Carmona, L; Agrinier, N; Andres, M; Briot, K; Caron, M; Christensen, R; Consolaro, A; Curbelo, R; Ferrer, Montserrat; Foltz, Violaine; Gonzalez, C; Guillemin, F; Machado, P M; Prodinger, Birgit; Ravelli, A; Scholte-Voshaar, M; Uhlig, T; van Tuyl, L H D; Zink, A; Gossec, L

2015-01-01

Patient reported outcomes (PROs) are relevant in rheumatology. Variable accessibility and validity of commonly used PROs are obstacles to homogeneity in evidence synthesis. The objective of this project was to provide a comprehensive library of "validated PROs". A launch meeting with rheumatologists, PROs methodological experts, and patients, was held to define the library's aims and scope, and basic requirements. To feed the library we performed systematic reviews on selected diseases and domains. Relevant information on PROs was collected using standardised data collection forms based on the COSMIN checklist. The EULAR Outcomes Measures Library (OML), whose aims are to provide and to advise on PROs on a user-friendly manner albeit based on scientific grounds, has been launched and made accessible to all. PROs currently included cover any domain and, are generic or specifically target to the following diseases: rheumatoid arthritis, osteoarthritis, spondyloarthritis, low back pain, systemic lupus erythematosus, gout, osteoporosis, juvenile idiopathic arthritis, and fibromyalgia. Up to 236 instruments (106 generic and 130 specific) have been identified, evaluated, and included. The systematic review for SLE, which yielded 10 specific instruments, is presented here as an example. The OML website includes, for each PRO, information on the construct being measured and the extent of validation, recommendations for use, and available versions; it also contains a glossary on common validation terms. The OML is an in progress library led by rheumatologists, related professionals and patients, that will help to better understand and apply PROs in rheumatic and musculoskeletal diseases.

Findings from the most recent Medical Library Association salary survey

PubMed Central

Wallace, Marc; McMullen, Thomas D.; Corcoran, Kate

2004-01-01

Objective: The objective is to provide information on basic issues in library management identified by the Medical Library Association's (MLA's) seventh triennial salary survey. Methods: The survey was a Web-based questionnaire. A nonrandom sample of persons was obtained by posting messages to MLA's membership and to the MEDLIB-L email discussion list. Employed MLA members and nonmembers employed in medical library settings filled out a Web-based form designed using common gateway interface (CGI) programming. Results: Six hundred forty-five usable responses were analyzed by the Hay Group and presented in the MLA publication, Hay Group/MLA 2001 Compensation and Benefits Survey. Results from the 2001 survey in this article focus on pay and job satisfaction. Salary survey results since 1983 were analyzed to review trends in seniority, diversity, and pay equity. Conclusions: Given the age progression of respondents from 1983 to 2001, it is clear that succession planning is a core issue for medical libraries. Although efforts to create more diversity in medical libraries in member organizations have started to yield results, pay for white respondents has increased at a higher rate than for other racial categories. The authors found that the pay-for-performance system in the organizations of approximately two-thirds of the respondents is suboptimized and that most of the reasons medical librarians cite for leaving their organization can be addressed and potentially changed by management. Results from the eighth salary survey, slated to be conducted in the fall of 2004, will further track these trends and issues. PMID:15494762

Progress in UNISIST Activity: The First Three Years of the UNISIST Programme in Australia, 1974-77. Network Study No. 8.

ERIC Educational Resources Information Center

National Library of Australia, Canberra.

This paper reprints the Australian report to UNISIST, the World Science Information System, whose objective is the development of national, regional, and international scientific, technological, industrial, and agricultural information policies, infrastructures, and services. It represents a full statement of the National Library's services and…

The Internet for Teachers and School Library Media Specialists: Today's Applications, Tomorrow's Prospects.

ERIC Educational Resources Information Center

Valauskas, Edward J.; Ertel, Monica

This book is a collection of "success stories" written by teachers, media specialists, and school administrators who have developed their own facilities to bring the Internet to their students. The book's four main parts parallel the stages educators progress through when incorporating the Internet into the instructional process. Part 1,…

Foreign Language Display Library Catalog. Supplement to Studies in Language and Language Behavior, Progress Report VIII.

ERIC Educational Resources Information Center

Ann Arbor Public Schools, MI.

Designed as a tool for foreign language teachers attempting to keep updated on the constantly proliferating number of printed materials being produced for use in elementary and secondary school language classes, this catalog attempts to bring together in one collection a representative selection of foreign language texts, readers, workbooks, and…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kartsaklis, Christos; Civario, G

This paper discusses an ongoing progress regarding the development of a Java-based library for rapid kernel prototyping in NVIDIA PTX and PTX instruction scheduling. It is aimed at developers seeking total control of emitted PTX, highly parametric emission of, and tunable instruction reordering. It is primarily used for code development at ICHEC but is also hoped that NVIDIA GPU community will also find it beneficial.

Virtual Screening as a Strategy for the Identification of Xenobiotics Disrupting Corticosteroid Action

PubMed Central

Praxmarer, Lukas; Chantong, Boonrat; Cereghetti, Diego; Winiger, Rahel; Schuster, Daniela; Odermatt, Alex

2012-01-01

Background Impaired corticosteroid action caused by genetic and environmental influence, including exposure to hazardous xenobiotics, contributes to the development and progression of metabolic diseases, cardiovascular complications and immune disorders. Novel strategies are thus needed for identifying xenobiotics that interfere with corticosteroid homeostasis. 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2) and mineralocorticoid receptors (MR) are major regulators of corticosteroid action. 11β-HSD2 converts the active glucocorticoid cortisol to the inactive cortisone and protects MR from activation by glucocorticoids. 11β-HSD2 has also an essential role in the placenta to protect the fetus from high maternal cortisol concentrations. Methods and Principal Findings We employed a previously constructed 3D-structural library of chemicals with proven and suspected endocrine disrupting effects for virtual screening using a chemical feature-based 11β-HSD pharmacophore. We tested several in silico predicted chemicals in a 11β-HSD2 bioassay. The identified antibiotic lasalocid and the silane-coupling agent AB110873 were found to concentration-dependently inhibit 11β-HSD2. Moreover, the silane AB110873 was shown to activate MR and stimulate mitochondrial ROS generation and the production of the proinflammatory cytokine interleukin-6 (IL-6). Finally, we constructed a MR pharmacophore, which successfully identified the silane AB110873. Conclusions Screening of virtual chemical structure libraries can facilitate the identification of xenobiotics inhibiting 11β-HSD2 and/or activating MR. Lasalocid and AB110873 belong to new classes of 11β-HSD2 inhibitors. The silane AB110873 represents to the best of our knowledge the first industrial chemical shown to activate MR. Furthermore, the MR pharmacophore can now be used for future screening purposes. PMID:23056542

Menthol cigarettes and smoking cessation behaviour: a review of tobacco industry documents

PubMed Central

2011-01-01

Objective To determine what the tobacco industry knew about menthol's relation to smoking cessation behaviour. Methods A snowball sampling design was used to systematically search the Legacy Tobacco Documents Library (LTDL) (http://legacy.library.ucsf.edu) between 15 May to 1 August 2010. Of the approximately 11 million documents available in the LTDL, the iterative searches returned tens of thousands of results. A final collection of 509 documents relevant to 1 or more of the research questions were qualitatively analysed, as follows: (1) perceived sensory and taste rewards of menthol and potential relation to quitting; and (2) motivation to quit among menthol users. Results Menthol's cooling and anaesthetic effects mask the short-term negative physiological effects of smoking such as throat pain, burning and cough. This provides superficial physical relief as well as psychological assurance against concerns about the health dangers of smoking that would otherwise motivate smokers to quit. Menthol smokers, particularly women, perceive the minty aroma of menthol cigarettes to be more socially acceptable than non-menthol cigarettes. Discussion Consumers believe menthol's sensory effects equate to health protections and that menthol cigarettes are more socially acceptable than non-menthol cigarettes. Menthol in cigarettes may encourage experimenters who find non-mentholated cigarettes too harsh, including young or inexperienced users, to progress to regular smoking rather than quitting, and may lessen the motivation to quit among established menthol smokers. The perception of menthol cigarettes as more socially acceptable lessens the impact of smoking denormalisation on quitting motivation. Menthol makes cigarettes easier and more palatable to smoke and less desirable to quit among established smokers. Fewer smokers quitting contributes to the incidence of tobacco-related diseases. PMID:21504932

46 CFR 172.195 - Survival conditions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... assumed damage if it meets the following conditions in the final stage of flooding: (a) Final waterline... of an opening through which progressive flooding may take place, such as an air pipe, or an opening... least 3.94 inches (10 cm). (3) Each submerged opening must be weathertight. (d) Progressive flooding. If...

46 CFR 172.195 - Survival conditions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... assumed damage if it meets the following conditions in the final stage of flooding: (a) Final waterline... of an opening through which progressive flooding may take place, such as an air pipe, or an opening... least 3.94 inches (10 cm). (3) Each submerged opening must be weathertight. (d) Progressive flooding. If...

46 CFR 172.195 - Survival conditions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... assumed damage if it meets the following conditions in the final stage of flooding: (a) Final waterline... of an opening through which progressive flooding may take place, such as an air pipe, or an opening... least 3.94 inches (10 cm). (3) Each submerged opening must be weathertight. (d) Progressive flooding. If...

Improvements to the Kunkel mutagenesis protocol for constructing primary and secondary phage-display libraries.

PubMed

Huang, Renhua; Fang, Pete; Kay, Brian K

2012-09-01

Site-directed mutagenesis is routinely performed in protein engineering experiments. One method, termed Kunkel mutagenesis, is frequently used for constructing libraries of peptide or protein variants in M13 bacteriophage, followed by affinity selection of phage particles. To make this method more efficient, the following two modifications were introduced: culture was incubated at 25°C for phage replication, which yielded two- to sevenfold more single-stranded DNA template compared to growth at 37°C, and restriction endonuclease recognition sites were used to remove non-recombinants. With both of the improvements, we could construct primary libraries of high complexity and that were 99-100% recombinant. Finally, with a third modification to the standard protocol of Kunkel mutagenesis, two secondary (mutagenic) libraries of a fibronectin type III (FN3) monobody were constructed with DNA segments that were amplified by error-prone and asymmetric PCR. Two advantages of this modification are that it bypasses the lengthy steps of restriction enzyme digestion and ligation, and that the pool of phage clones, recovered after affinity selection, can be used directly to generate a secondary library. Screening one of the two mutagenic libraries yielded variants that bound two- to fourfold tighter to human Pak1 kinase than the starting clone. The protocols described in this study should accelerate the discovery of phage-displayed recombinant affinity reagents. Copyright © 2012 Elsevier Inc. All rights reserved.

Criteria-based evaluation of group 3 level memory telefacsimile equipment for interlibrary loan.

PubMed Central

Bennett, V M; Wood, M S; Malcom, D L

1990-01-01

The Interlibrary Loan, Document Delivery, and Union List Task Force of the Health Sciences Libraries Consortium (HSLC)--with nineteen libraries located in Philadelphia, Pittsburgh, and Hershey, Pennsylvania, and Delaware--accepted the charge of evaluating and recommending for purchase telefacsimile hardware to further interlibrary loan among HSLC members. To allow a thorough and scientific evaluation of group 3 level telefacsimile equipment, the task force identified ninety-six hardware features, which were grouped into nine broad criteria. These features formed the basis of a weighted analysis that identified three final candidates, with one model recommended to the HSLC board. This article details each of the criteria and discusses features in terms of library applications. The evaluation grid developed in the weighted analysis process should aid librarians charged with the selection of level 3 telefacsimile equipment. PMID:2328361

Component Technology for High-Performance Scientific Simulation Software

DOE Office of Scientific and Technical Information (OSTI.GOV)

Epperly, T; Kohn, S; Kumfert, G

2000-11-09

We are developing scientific software component technology to manage the complexity of modem, parallel simulation software and increase the interoperability and re-use of scientific software packages. In this paper, we describe a language interoperability tool named Babel that enables the creation and distribution of language-independent software libraries using interface definition language (IDL) techniques. We have created a scientific IDL that focuses on the unique interface description needs of scientific codes, such as complex numbers, dense multidimensional arrays, complicated data types, and parallelism. Preliminary results indicate that in addition to language interoperability, this approach provides useful tools for thinking about themore » design of modem object-oriented scientific software libraries. Finally, we also describe a web-based component repository called Alexandria that facilitates the distribution, documentation, and re-use of scientific components and libraries.« less

Analysis of the Browns Ferry Unit 3 irradiation experiments. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simmons, G.L.

1984-11-01

The results of the analysis of two experiments performed at the Browns Ferry-3 reactor are presented. These calculations utilize state-of-the-art neutron transport techniques and a new neutron cross-section library that has been developed for LWR applications. The calculations agree well with the experimental data obtained in irradiations inside the reactor vessel. For the measurements performed in the reactor cavity, the calculations agree well at the reactor midplane. Accurate determination of the axial distribution of the neutron fluence in the reactor cavity depends on having a concise representation of the axial-void distribution in the core. Detailed data are presented describing themore » procedures used in the generation of the new cross-section library that has been named SAILOR. This library is available from the Radiation-Shielding Information Center.« less

Structure Based Library Design (SBLD) for new 1,4-dihydropyrimidine scaffold as simultaneous COX-1/COX-2 and 5-LOX inhibitors.

PubMed

Lokwani, Deepak; Azad, Rajaram; Sarkate, Aniket; Reddanna, Pallu; Shinde, Devanand

2015-08-01

The various scaffolds containing 1,4-dihydropyrimidine ring were designed by considering the environment of the active site of COX-1/COX-2 and 5-LOX enzymes. The structure-based library design approach, including the focused library design (Virtual Combinatorial Library Design) and virtual screening was used to select the 1,4-dihydropyrimidine scaffold for simultaneous inhibition of both enzyme pathways (COX-1/COX-2 and 5-LOX). The virtual library on each 1,4-dihydropyrimidine scaffold was enumerated in two alternative ways. In first way, the chemical reagents at R groups were filtered by docking of scaffold with single position substitution, that is, only at R1, or R2, or R3, … Rn on COX-2 enzyme using Glide XP docking mode. The structures that do not dock well were removed and the library was enumerated with filtered chemical reagents. In second alternative way, the single position docking stage was bypassed, and the entire library was enumerated using all chemical reagents by docking on the COX-2 enzyme. The entire library of approximately 15,629 compounds obtained from both ways after screening for drug like properties, were further screened for their binding affinity against COX-1 and 5-LOX enzymes using Virtual Screening Workflow. Finally, 142 hits were obtained and divided into two groups based on their binding affinity for COX-1/COX-2 and for both enzyme pathways (COX-1/COX-2 and 5-LOX). The ten molecules were selected, synthesized and evaluated for their COX-1, COX-2 and 5-LOX inhibiting activity. Copyright © 2015 Elsevier Ltd. All rights reserved.