Contacts in the Office of Pesticide Programs, Registration Division

EPA Pesticide Factsheets

The Registration Division (RD) is responsible product registrations, amendments, registrations, tolerances, experimental use permits, and emergency exemptions for conventional chemical pesticides. Find contacts in this division.

Psychological factors in breast feeding versus bottle feeding in the Third World.

PubMed

Berry, N; Mccullough, M

1982-09-01

Some readers may be aware of the sociopolitical and moral issues associated with the theme of Brenda Meldrum's article (Bulletin, June 1982) about breast and bottle feeding in the 3rd world. For over a decade many groups (e.g. War on Want; World Development Movement) have been concerned that unnecessary bottle feeding has almost certainly resulted in considerable infant disease and mortality in the 3rd world. Morever, such groups have been well aware of the high psychological value of formula foods; and have attributed this mainly to the aggressive and fundamentally dishonest way in which food companies promote their breastmilk substitutes. In 1979, in response to the bad publicity resulting from the campaigning of 3rd world agencies, Nestle and others agreed to adopt a voluntary code of practice proposed by World Health Organization and UNICEF. However, commercial interests have prevailed--baby food sales in 3rd world account for 2 1/2% of 1 transnational group's turnover--and the malpractices have continued. In view of this we feel that it is appropriate to amend Brenda Meldrum's conclusion to: While transnational corporations continue to actively promote their baby food products in the 3rd world, there can be no reversal to the old, exclusive breastfeeding of traditional practice, and that infants that would otherwise have lived will continue to die. The boycott campaign is continuing and might we suggest that BPS members who organize conferences give some thought to the possibility of requesting that their caterers do not use products of these companies. A list of companies may be obtained from New Internationalist (February 1982) or from us. full text

78 FR 19585 - Change of Address; Biologics License Applications; Technical Amendment

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-02

... Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Bldg. 22, rm. 1120, Silver... and Research, Food and Drug Administration, 5901B Ammendale Rd., Beltsville, MD 20705. This action is...

Career intentions and choices of paediatricians entering training in the UK.

PubMed

Shortland, David; Roland, Damian; Lumsden, Daniel Edward; Ewing, Carol; L'Esperance, Veline; McColgan, Martin; Winch, Rachel; Mahmood, Shazia

2015-06-01

The paediatric workforce has grown substantially in recent years. Roles have changed considerably with the introduction of working time legislation and a move towards a trained doctor solution. By gaining a better understanding of paediatric trainees' career intentions, this study aims to assess whether the right workforce is being trained to meet the future demand for paediatric services in the UK. A survey was sent to paediatric specialist trainees, when they were expected to have completed their 1st year of Specialty Training or Fixed Term Specialty Training Appointments, in 2009 (part 1). A second survey was sent to the same cohort when they were expected to have completed their 3rd year in 2011 (part 2). In part 1 of the survey, the response rate was 79.1%. In part 2 the response rate was 80.5%. Of those who had responded to part 1, 87.4% also responded to part 2. The attrition rate of trainees leaving the paediatric training scheme between the 1st year and 3rd year of training was 15%. Of those still training in paediatrics after the 3rd year, 38.7% intended to be subspecialty paediatricians, 25.7% general paediatricians, 5.4% community paediatricians and 3.5% academic paediatricians. 26% were undecided and 0.6% did not intend to follow a career in paediatrics at all. The proportion of trainees who were undecided about their career intentions had risen substantially from 7.7% after the 1st year. There was a decrease in trainees' confidence in obtaining a consultant post between the 1st year and the 3rd year. Workforce planning is a complex task and this study shows that trainees will change their career plans while progressing through their run-through programmes. A better understanding of these factors will enable the Royal College of Paediatrics and Chld Health to deliver the right workforce for the UK. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

77 FR 2711 - Equity and Excellence Commission

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-19

... DEPARTMENT OF EDUCATION Equity and Excellence Commission AGENCY: Office for Civil Rights, Education. ACTION: Notice of open meeting (Amended). SUMMARY: On January 5, 2012, the Office for Civil... will participate in an Ethics briefing prior to the start of the January 23rd meeting This notice sets...

32 CFR 644.417 - For MCA family housing.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 4 2011-07-01 2011-07-01 false For MCA family housing. 644.417 Section 644.417... family housing. The Act of 1 September 1954, Pub. L. 765, 83rd Congress (68 Stat. 1119), as amended by... Construction-Army Family Housing at Military Installations and Facilities.” ...

A resolution recognizing the 193rd anniversary of the independence of Greece and celebrating democracy in Greece and the United States.

THOMAS, 113th Congress

Sen. Menendez, Robert [D-NJ

2014-03-10

Senate - 03/13/2014 Resolution agreed to in Senate without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

32 CFR 644.417 - For MCA family housing.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true For MCA family housing. 644.417 Section 644.417... family housing. The Act of 1 September 1954, Pub. L. 765, 83rd Congress (68 Stat. 1119), as amended by... Construction-Army Family Housing at Military Installations and Facilities.” ...

77 FR 13232 - Abbott Laboratories; Filing of Food Additive Petition

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-06

.... FDA-2012-F-0138] Abbott Laboratories; Filing of Food Additive Petition AGENCY: Food and Drug... that Abbott Laboratories has filed a petition proposing that the food additive regulations be amended... given that a food additive petition (FAP 2A4788) has been filed by Abbott Laboratories, 3300 Stelzer Rd...

Nutrient Supplying Potential of Different Spent Mushroom Substrate Preparations as Soil Amendment in a Potting Media

NASA Astrophysics Data System (ADS)

Ultra, VU, Jr.; Ong Sotto, JME; Punzalan, MR

2018-03-01

A three consecutive cropping experiment was conducted to evaluate the nutrient supplying potential of different preparations of the spent mushroom substrate as an amendment of growing media for potted plants using pechay as test plant. There are 12 treatment combinations consisted 4 types of growing media containing soil alone and mixtures of soil with fresh SMS (FSMS), weathered SMS (WSMS) and carbonized SMS (CSMS) in combination with 0%, 50% or 100% recommended rate (RR) of nitrogen fertilizer. Succeeding two trials were conducted on the same pots and treatment assignments. The high yield of pechay during the first and second crop was observed on WSMS and CSMS treatments FSMS media produced high yields only during the 3rd crop. Yield was increased by N fertilizer in WSMS and CSMS treatments but not in FSMS. The growth differences is attributed to differences in available nutrients and C/N ratio between treatments. WSMS and CSMS increased the available N while FSMS immobilized N and other nutrients indicting that weathered SMS and carbonized SMS are more suitable as a component of potting media or as soil amendments without detrimental effect on immobilization and availability of nutrients.

Children and Gun Violence. Hearings on S. 1087, a Bill To Amend Title 18, United States Code, To Prohibit the Possession of a Handgun or Ammunition by, or the Private Transfer of a Handgun or Ammunition to, a Juvenile, before the Subcommittee on Juvenile Justice of the Committee on the Judiciary. United States Senate, 103rd Congress, First Session.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate Committee on the Judiciary.

This transcript contains the following: (1) statements of several Committee Members; (2) text of the proposed legislation; (3) a list of witnesses; and (4) statements, testimony, and supporting documents submitted by the witnesses. Numerous laypersons and professionals have their testimonies recorded, giving statements in support of and in…

78 FR 23472 - Amendments to Existing Validated End-User Authorizations: CSMC Technologies Corporation in the...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-19

... of Wuxi CR Semiconductor Wafers & Chips Co., Ltd. and CSMC Technologies Fab 1 Co., Ltd., which is... Validated End-User: CSMC Technologies Corporation. Eligible Destinations: CSMC Technologies Fab 1 Co., Ltd., 14 Liangxi Road, Wuxi, Jiangsu 214061, China. CSMC Technologies Fab 2 Co., Ltd., 8 Xinzhou Rd., Wuxi...

A resolution commending the National Association for the Advancement of Colored People on the occasion of its 103rd anniversary.

THOMAS, 112th Congress

Sen. Cardin, Benjamin L. [D-MD

2012-07-16

Senate - 07/16/2012 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

The impact of Ontario’s extended drinking hours on cross-border cities of Windsor and Detroit

PubMed Central

Vingilis, E.; McLeod, A.I.; Seeley, J.; Mann, R.; Voas, R.; Compton, C.

2008-01-01

Purpose This study evaluated the cross-border safety impact of extended drinking hours from 1:00 to 2:00 a.m., in licensed establishments in Ontario, Canada. Methods This study examined patterns in total and alcohol-related casualties in: (1) Windsor, Ontario, Canada compared to Detroit, Michigan, US with a 2:00 a.m. closing time, and (2) Ontario compared to Michigan for overall trends. The criterion outcome indicators were: (1) monthly motor vehicle casualties (major injuries and fatalities) for the city-regions of Windsor and Detroit and (2) Ontario and Michigan monthly motor vehicle fatalities occurring between 11:00 p.m. and 3:00 a.m. for 4 years pre- and 3 years post-policy change. In order to examine cross-border drinking consequences, data were disaggregated to assess trends of motor vehicle injury collisions involving vehicles with US licence plates and with US drivers aged 16–20 in the Windsor region; similarly trends were assessed for motor vehicle injury collisions involving vehicles with Ontario licence plates in the Detroit region. Results The Windsor region total motor vehicle casualty data showed a non-significant pre–post increase, while the Detroit region showed a statistically significant decrease for total motor vehicle casualties. In the Windsor region, a significant increase was found for alcohol-related motor vehicle casualties after the drinking hours were extended. However, the Detroit region showed a statistically significant decrease in alcohol-related motor vehicle casualties concomitant with Ontario’s drinking hour extension. No similar trends were found for the province of Ontario and the state of Michigan as a whole. Moreover, a significant decrease was found for injury collisions involving vehicles with Ontario licence plates in the Detroit region but no similar pattern was found for injury collisions involving vehicles with US licence plates and with 16–20-year-old US drivers in the Windsor region. Discussion These data seem to support a cross-border impact of the Ontario extended drinking policy. A significant increase in alcohol-related motor vehicle casualties was found in the Windsor region and concomitantly, significant decreases in total and alcohol-related motor vehicle casualties were found in the Detroit region after the extended drinking hours amendment. The Ontario government’s belief that the extended drinking hour policy would “reduce the number of patrons who cross the border when Ontario’s bars and restaurants close” may have been realized. PMID:16169506

American Film Institute, 1974; Hearing before the Special Subcommittee on Arts and Humanities of the Committee on Labor and Public Welfare, U.S. Senate, 93rd Congress, Second Session on H.R. 17504, To Amend the National Foundation on the Arts and the Humanities Act of 1965 to Create the American Film Institute as an Independent Agency, December 11, 1974.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate Committee on Labor and Public Welfare.

This report is on the Senate Subcommittee hearing on December 11, 1974, to amend the National Foundation on the Arts and the Humanities Act of 1965 to create the American Film Institute as an independent agency. Witnesses testifying before the subcommittee included: George Stevens, Charlton Heston, Roger Stevens, Harry McPherson, William Lehman,…

76 FR 2709 - Amended Certification Regarding Eligibility To Apply for Worker Adjustment Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-14

... for Worker Adjustment Assistance TA-W-72,873 RBS Citizens, N.A., Business Services, Including On-Site... Through NextGen Information Services, Inc., 1 Citizens Drive, Riverside, Rhode Island TA-W-72,873c RBS... Cabot Rd., Medford, Massachusetts TA-W-72,873G RBS Citizens, N.A., Business Services, Including On-Site...

77 FR 14287 - Aspergillus flavus AF36; Amendment to an Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-09

... Arizona Cotton Research and Protection Council, Interregional Research Project Number 4 submitted a... College Rd. East, Suite 201W, Princeton, NJ 08540 (on behalf of the Arizona Cotton Research and Protection... petitioner, IR-4 (on behalf of the Arizona Cotton Research and Protection Council), which is available in the...

Global approaches to regulating electronic cigarettes.

PubMed

Kennedy, Ryan David; Awopegba, Ayodeji; De León, Elaine; Cohen, Joanna E

2017-07-01

Classify and describe the policy approaches used by countries to regulate e-cigarettes. National policies regulating e-cigarettes were identified by (1) conducting web searches on Ministry of Health websites, and (2) broad web searches. The mechanisms used to regulate e-cigarettes were classified as new/amended laws, or existing laws. The policy domains identified include restrictions or prohibitions on product: sale, manufacturing, importation, distribution, use, product design including e-liquid ingredients, advertising/promotion/sponsorship, trademarks, and regulation requiring: taxation, health warning labels and child-safety standards. The classification of the policy was reviewed by a country expert. The search identified 68 countries that regulate e-cigarettes: 22 countries regulate e-cigarettes using existing regulations; 25 countries enacted new policies to regulate e-cigarettes; 7 countries made amendments to existing legislation; 14 countries use a combination of new/amended and existing regulation. Common policies include a minimum-age-of-purchase, indoor-use (vape-free public places) bans and marketing restrictions. Few countries are applying a tax to e-cigarettes. A range of regulatory approaches are being applied to e-cigarettes globally; many countries regulate e-cigarettes using legislation not written for e-cigarettes. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

75 FR 29441 - Novaluron; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-26

... amend existing tolerances of novaluron in or on poultry, fat from 0.40 ppm to 7.0 ppm; poultry, meat from 0.03 ppm to 0.40 ppm; poultry, meat byproducts from 0.04 ppm to 0.80 ppm; hog, fat from 0.05 ppm..., Environmental Science Center, 701 Mapes Rd., Ft. Meade, MD 20755-5350; telephone number: (410) 305-2905; e-mail...

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (83rd, Phoenix, Arizona, August 9-12, 2000). Cultural and Critical Studies Division.

ERIC Educational Resources Information Center

Association for Education in Journalism and Mass Communication.

The Cultural and Critical Studies Division section of the proceedings contains the following 11 papers: "'Grimm' News Indeed--'Madstones,' Clever Toads, and Killer Tarantulas: Fairy-Tale Briefs in Wild West Newspapers" (Paulette Kilmer); "The First Amendment and the Doctrine of Corporate Personhood: Collapsing the Press-Corporation…

A resolution recognizing Major League Baseball as an important part of the cultural history of American society, celebrating the 2012 Major League Baseball All-Star Game, and honoring Kansas City, Missouri, as the host city of the 83rd All-Star Game.

THOMAS, 112th Congress

Sen. Blunt, Roy [R-MO

2012-06-26

Senate - 06/26/2012 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

Reading Emphasis Programs, 1973; Hearings before the Subcommittee on Education of the Committee on Labor and Public Welfare, U.S. Senate, 93rd Congress, S. 1318 and S. 2069.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate Committee on Labor and Public Welfare.

This report is on the Senate Education Subcommittee Hearing on bills to amend the elementary and secondary education act of 1965, to authorize reading emphasis programs to improve reading in the primary grades, and for other purposes (S. 1318); and to improve national reading skills (S. 2069). Witnesses testifying before the subcommittee included…

A resolution recognizing the 63rd anniversary of India's independence, expressing appreciation to Americans of Indian descent for their contributions to society, and expressing support and optimism for the strategic partnership and friendship between the United States and India in the future.

THOMAS, 111th Congress

Sen. Cornyn, John [R-TX

2010-08-05

Senate - 08/05/2010 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

Heavy metal phytoextraction by Sedum alfredii is affected by continual clipping and phosphorus fertilization amendment.

PubMed

Huang, Huagang; Li, Tingqiang; Gupta, D K; He, Zhenli; Yang, Xiao-E; Ni, Bingnan; Li, Mao

2012-01-01

Improving the efficacy of phytoextraction is critical for its successful application in metal contaminated soils. Mineral nutrition affects plant growth and metal absorption and subsequently the accumulation of heavy metal through hyper-accumulator plants. This study assessed the effects of di-hydrogen phosphates (KH2PO4, Ca(H2PO4)2, NaH2PO4 and NH4H2PO4) application at three levels (22, 88 and 352 mg P/kg soil) on Sedum alfredii growth and metal uptake by three consecutive harvests on aged and Zn/Cd combined contaminated paddy soil. The addition of phosphates (P) significantly increased the amount of Zn taken up by S. alfredii due to increased shoot Zn concentration and dry matter yield (DMY) (P < 0.05). The highest phytoextraction of Zn and Cd was observed in KH2PO4 and NH4H2PO4 treatment at 352 mg P/kg soil. The amount of Zn removed by phytoextraction increased in the order of 1st clipping < 2nd clipping < 3rd clipping, and for Cd extraction the order was 2nd clipping < 1st clipping < 3rd clipping. These results indicate that the application of P fertilizers coupled with multiple cuttings can enhance the removal of Zn and Cd from contaminated soils by S. alfredii, thus shortening the time needed for accomplishing remediation goals.

CO2 efflux from soil under influence of cadmium and glucose

NASA Astrophysics Data System (ADS)

Gilmullina, Aliia; Galitskaya, Polina; Selivanovskaya, Svetlana

2017-04-01

Soil is the largest pool of organic carbon. Any anthropogenic activity may change the soil organic carbon stock resulting in the atmospheric carbon concentration increase. Organic wastes and sewage sludge are often used for soil fertilization. These amendments often contain not only organic compounds stimulating soil microflora but also toxic compounds e.g. metals inhibiting them. The question about the influence of such amendments on soil carbon stock still remains open. The aim of this study was to evaluate individual glucose and cadmium (Cd) additions and their combined effects on carbon mineralization and microbial community structure in forest soil sampled from different depths (0-20 cm, 20-40 cm and 40-60 cm). We incubated soil samples for 14 days after the addition of: glucose (10000 mg kg-1), Cd (300 mg kg-1) and their mixture. CO2 efflux was measured by CO2 trapping in NaOH, at the 3rd, 7th and 14th days of incubation DNA was extracted from soil samples for assessment of microbial community structure via real-time PCR and Illumina sequencing. Glucose addition induced the increase of soil respiration and fungal-bacterial ratio. However, bacterial alpha-biodiversity decreased as glucose addition caused the dominance of Proteobacteria (0-20 cm, 20-40 cm and 40-60 cm), Actinobacteria (20-40 cm) and Acidobacteria (40-60 cm) phyla. Single Cd addition did not have any effect on parameters studied. In case of simultaneous addition of glucose and Cd, soil respiration and microbial community structure mainly depended more on glucose amendment as compared with metal.

Effect of cricoid pressure on laryngeal view during prehospital tracheal intubation: a propensity-based analysis.

PubMed

Caruana, Emmanuel; Chevret, Sylvie; Pirracchio, Romain

2017-03-01

The benefit of cricoid pressure during tracheal intubation is still debated and, due to its potential negative impact on laryngeal views, its routine use is questioned. The goal of this study was to estimate its impact on laryngeal view. All patients intubated in the prehospital setting were included. Three different propensity score (PS) models were used and compared in terms of the balance achieved between those patients who received cricoid pressure and those who did not. The PS model that optimised the balance was retained in order to estimate the relationship between cricoid pressure and the following outcomes: difficult laryngoscopy, intubation-related complications and difficult intubation. Among the 1195 patients included, 499 (41.7%) received cricoid pressure. The optimal PS included seven variables (cardiac arrest, altered neurological status, shock, respiratory distress, gender, obesity, patient's position). After PS matching, no significant risk difference (RD) in the rate of difficult laryngoscopy was found between the patients who received cricoid pressure and those who did not (RD=0.001, 95% CI -0.07 to 0.08, p=0.50). No significant difference was found in terms of difficult intubation (RD=0.06, 95% CI -0.13 to 0.25, p=0.28) and in terms of prevalence of complications, except for airway trauma that were more frequent in cricoid pressure group (RD=0.03, 95% CI 0.002 to 0.05, p=0.01). No significant relationship was found between the use of cricoid pressure for prehospital intubation and difficult laryngoscopy. Cricoid pressure was found to be associated with more airway trauma. This finding could question its routine use. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Evaluation of BAUER K220 High Pressure Breathing Air Compressor

DTIC Science & Technology

1990-03-01

switch , intermediate 6 Inter-cooler lstf2nd stage pressure lst/2nd stage 7 Inter-cooler 2nd/3rd stage 25 Pressure switch , intermediate 8 Inter-cooler...3rd/4th stage pressure 2nd/3rd stage 9 After-cooler 26 Pressure switch , intermediate 10 Inter-filter 2nd/3rd stage pressure 3rd/4th stage 11 Inter...filter 3rd/4th stage 27 Temperature switch 4th stage 12 Oil and water separator 28 Final pressure switch . 13 Safety valve 1st stage 29 3/2-way solenoid

Soil microbial properties after long-term swine slurry application to conventional and no-tillage systems in Brazil.

PubMed

Balota, Elcio L; Machineski, Oswaldo; Hamid, Karima I A; Yada, Ines F U; Barbosa, Graziela M C; Nakatani, Andre S; Coyne, Mark S

2014-08-15

Swine waste can be used as an agricultural fertilizer, but large amounts may accumulate excess nutrients in soil or contaminate the surrounding environment. This study evaluated long-term soil amendment (15 years) with different levels of swine slurry to conventional (plow) tillage (CT) and no tillage (NT) soils. Long-term swine slurry application did not affect soil organic carbon. Some chemical properties, such as calcium, base saturation, and aluminum saturation were significantly different within and between tillages for various application rates. Available P and microbial parameters were significantly affected by slurry addition. Depending on tillage, soil microbial biomass and enzyme activity increased up to 120 m(3) ha(-1) year(-1) in all application rates. The NT system had higher microbial biomass and activity than CT at all application levels. There was an inverse relationship between the metabolic quotient (qCO2) and MBC, and the qCO2 was 53% lower in NT than CT. Swine slurry increased overall acid phosphatase activity, but the phosphatase produced per unit of microbial biomass decreased. A comparison of data obtained in the 3rd and 15th years of swine slurry application indicated that despite slurry application the CT system degraded with time while the NT system had improved values of soil quality indicators. For these Brazilian oxisols, swine slurry amendment was insufficient to maintain soil quality parameters in annual crop production without additional changes in tillage management. Copyright © 2014 Elsevier B.V. All rights reserved.

Liquor landscapes: Does access to alcohol outlets influence alcohol consumption in young adults?

PubMed

Foster, Sarah; Trapp, Georgina; Hooper, Paula; Oddy, Wendy H; Wood, Lisa; Knuiman, Matthew

2017-05-01

Few longitudinal studies have examined the impact of liquor licences on alcohol consumption, and none in young adults, the life stage when alcohol intake is at its highest. We examined associations between liquor licences (i.e., general licences, on-premise licences, liquor stores, and club licences) and alcohol consumption at 20-years (n=988) and 22-years (n=893), and whether changes in the licences between time-points influenced alcohol consumption (n=665). Only general licences were associated with alcohol consumption at 20-years (p=0.037), but by 22-years, all licences types were positively associated with alcohol consumption (p<0.05). Longitudinal analyses showed that for each increase in liquor stores over time, alcohol consumption increased by 1.22g/day or 8% (p=0.030), and for each additional club licence, consumption increased by 0.90g/day or 6% (p=0.007). Limiting liquor licences could contribute to a reduction in young adults' alcohol intake. Copyright © 2017 Elsevier Ltd. All rights reserved.

Suicide tourism: a pilot study on the Swiss phenomenon.

PubMed

Gauthier, Saskia; Mausbach, Julian; Reisch, Thomas; Bartsch, Christine

2015-08-01

While assisted suicide (AS) is strictly restricted in many countries, it is not clearly regulated by law in Switzerland. This imbalance leads to an influx of people-'suicide tourists'-coming to Switzerland, mainly to the Canton of Zurich, for the sole purpose of committing suicide. Political debate regarding 'suicide tourism' is taking place in many countries. Swiss medicolegal experts are confronted with these cases almost daily, which prompted our scientific investigation of the phenomenon. The present study has three aims: (1) to determine selected details about AS in the study group (age, gender and country of residence of the suicide tourists, the organisation involved, the ingested substance leading to death and any diseases that were the main reason for AS); (2) to find out the countries from which suicide tourists come and to review existing laws in the top three in order to test the hypothesis that suicide tourism leads to the amendment of existing regulations in foreign countries; and (3) to compare our results with those of earlier studies in Zurich. We did a retrospective data analysis of the Zurich Institute of Legal Medicine database on AS of non-Swiss residents in the last 5 years (2008-2012), and internet research for current legislation and political debate in the three foreign countries most concerned. We analysed 611 cases from 31 countries all over the world. Non-terminal conditions such as neurological and rheumatic diseases are increasing among suicide tourists. The unique phenomenon of suicide tourism in Switzerland may indeed result in the amendment or supplementary guidelines to existing regulations in foreign countries. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Transcriptional regulation of ABI3- and ABA-responsive genes including RD29B and RD29A in seeds, germinating embryos, and seedlings of Arabidopsis.

PubMed

Nakashima, Kazuo; Fujita, Yasunari; Katsura, Koji; Maruyama, Kyonoshin; Narusaka, Yoshihiro; Seki, Motoaki; Shinozaki, Kazuo; Yamaguchi-Shinozaki, Kazuko

2006-01-01

ABA-responsive elements (ABREs) are cis-acting elements and basic leucine zipper (bZIP)-type ABRE-binding proteins (AREBs) are transcriptional activators that function in the expression of RD29B in vegetative tissue of Arabidopsis in response to abscisic acid (ABA) treatment. Dehydration-responsive elements (DREs) function as coupling elements of ABRE in the expression of RD29A in response to ABA. Expression analysis using abi3 and abi5 mutants showed that ABI3 and ABI5 play important roles in the expression of RD29B in seeds. Base-substitution analysis showed that two ABREs function strongly and one ABRE coupled with DRE functions weakly in the expression of RD29A in embryos. In a transient transactivation experiment, ABI3, ABI5 and AREB1 activated transcription of a GUS reporter gene driven by the RD29B promoter strongly but these proteins activated the transcription driven by the RD29A promoter weakly. In 35S::ABI3 Arabidopsis plants, the expression of RD29B was up-regulated strongly, but that of RD29A was up-regulated weakly. These results indicate that the expression of RD29B having ABREs in the promoter is up-regulated strongly by ABI3, whereas that of RD29A having one ABRE coupled with DREs in the promoter is up-regulated weakly by ABI3. We compared the expression of 7000 Arabidopsis genes in response to ABA treatment during germination and in the vegetative growth stage, and that in 35S::ABI3 plants using a full-length cDNA microarray. The expression of ABI3- and/or ABA-responsive genes and cis-elements in the promoters are discussed.

Cyanidin-3-glucoside extracted from mulberry fruit can reduce N-methyl-N-nitrosourea-induced retinal degeneration in rats.

PubMed

Lee, Seung Hee; Jeong, Eojin; Paik, Sun-Sook; Jeon, Ji Hyun; Jung, Sung Won; Kim, Hyun-Bok; Kim, Muyan; Chun, Myung-Hoon; Kim, In-Beom

2014-01-01

To investigate the effect of cyanidin-3-O-glucoside (C3G) on a rat retinal degeneration (RD) model. Experimental RD was induced in rats by the intraperitoneal injection of N-methyl-N-nitrosourea (MNU) at 50 mg/kg. C3G extracted from mulberry (Morus alba L.) fruit (50 mg/kg) was orally administered, daily for 1, 2 and 4 weeks after MNU injection. The effects of C3G administration on MNU-induced RD retinas were histologically and functionally assessed by hematoxylin and eosin staining and electroretinography (ERG), respectively. The degree of retinal injury in C3G-administered RD rats was evaluated by immunohistochemistry with an antibody against glial fibrillary acidic protein (GFAP). The preferential protective effect of C3G on scotopic vision was examined by western blot analysis. Marked loss of photoreceptors in the outer nuclear layer (ONL) was observed in RD rats at 2 and 4 weeks after MNU injection, while the ONL in the MNU-induced RD rats given C3G was relatively well preserved. Immunohistochemistry with anti-GFAP showed that retinal injury was also reduced in the retinas of the rats given C3G. Functional assessment by using ERG recordings showed that scotopic ERG responses were significantly increased in RD rats given C3G for 4 weeks (p < 0.01) compared with that of untreated RD rats. In the RD rats given short-term C3G (for 1 and 2 weeks), the increase in ERG responses was not significant. In addition, western blot analysis showed that rhodopsin level in the C3G-administered RD retinas significantly increased compared to that in the non-administered RD retinas (p < 0.05), whereas red/green opsin level did not show any significant difference. Long-term administration of C3G extracted from mulberry fruit could structurally reduce photoreceptor damage and functionally improve scotopic visual functions in the RD rat model induced by MNU.

Projected savings through public health voluntary licences of HIV drugs negotiated by the Medicines Patent Pool (MPP).

PubMed

Juneja, Sandeep; Gupta, Aastha; Moon, Suerie; Resch, Stephen

2017-01-01

The Medicines Patent Pool (MPP) was established in 2010 to ensure timely access to low-cost generic versions of patented antiretroviral (ARV) medicines in low- and middle-income countries (LMICs) through the negotiation of voluntary licences with patent holders. While robust data on the savings generated by MPP and other major global public health initiatives is important, it is also difficult to quantify. In this study, we estimate the savings generated by licences negotiated by the MPP for ARV medicines to treat HIV/AIDS in LMICs for the period 2010-2028 and generate a cost-benefit ratio-based on people living with HIV (PLHIVs) in any new countries which gain access to an ARV due to MPP licences and the price differential between originator's tiered price and generics price, within the period where that ARV is patented. We found that the direct savings generated by the MPP are estimated to be USD 2.3 billion (net present value) by 2028, representing an estimated cost-benefit ratio of 1:43, which means for every USD 1 spent on MPP, the global public health community saves USD 43. The saving of USD 2.3 billion is equivalent to more than 24 million PLHIV receiving first-line ART in LMICs for 1 year at average prices today.

Pre-licensed driving experience and car crash involvement during the learner and restricted, licence stages of graduated driver licensing: Findings from the New Zealand drivers study.

PubMed

Begg, Dorothy J; Langley, John D; Brookland, Rebecca L; Ameratunga, Shanthi; Gulliver, Pauline

2014-01-01

The aim of this study was to determine whether pre-licence driving experiences, that is driving before beginning the licensing process, increased or decreased crash risk as a car driver, during the learner or the restricted licence stages of the graduated driver licensing system (GDLS). Study participants were 15-24 year old members of the New Zealand Drivers Study (NZDS) - a prospective cohort study of newly licensed car drivers. The interview stages of the NZDS are linked to, the three licensing stages of the GDLS: learner, restricted and full. Baseline demographic (age, ethnicity, residential location, deprivation), personality (impulsivity, sensation seeking, aggression) and, behavioural data, (including pre-licensed driving behaviour), were obtained at the learner licence interview. Data on distance driven and crashes that occurred at the learner licence and restricted licence stages, were reported at the restricted and full licence interviews, respectively. Crash data were also obtained from police traffic crash report files and this was combined with the self-reported crash data. The analysis of the learner licence stage crashes, when only supervised driving is allowed, was based on the participants who had passed the restricted licence test and undertaken the NZDS, restricted licence interview (n=2358). The analysis of the restricted licence stage crashes, when unsupervised driving is first allowed, was based on those who had passed the full licence test and completed the full licence interview (n=1428). After controlling for a range of demographic, personality, behavioural variables and distance driven, Poisson regression showed that the only pre-licence driving behaviour that showed a consistent relationship with subsequent crashes was on-road car driving which was associated with an increased risk of being the driver in a car crash during the learner licence period. This research showed that pre-licensed driving did not reduce crash risk among learner or restricted licensed drivers, and in some cases (such as on-road car driving) may have increased risk. Young people should be discouraged from the illegal behaviour of driving a car on-road before licensing. Copyright © 2013 Elsevier Ltd. All rights reserved.

80. GENERAL VIEW TO NORTH ON 3RD AVENUE EL AT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

80. GENERAL VIEW TO NORTH ON 3RD AVENUE EL AT GUN HILL STATION. 7TH AVENUE EL EXPRESS IS VISIBLE ABOVE THE 3RD AVENUE EL WHICH JOINED ONTO THE SAME STRUCTURE AT GUN HILL ROAD. NOTE: GUN HILL ROAD IS THE NORTH TERMINUS OF THE 3RD AVENUE ELEVATED. TRAINS DID NOT CARRY PASSENGERS BEYOND THIS POINT, ALTHOUGH THE 3RD AVENUE TRACK DID EXTEND FURTHER NORTH FOR SWITCHING PURPOSES AND INTO THE YARDS. - Interborough Rapid Transit Company, Third Avenue Elevated Line, Borough of the Bronx, New York County, NY

Do parental education and income matter? A nationwide register-based study on HPV vaccine uptake in the school-based immunisation programme in Norway.

PubMed

Feiring, Berit; Laake, Ida; Molden, Tor; Cappelen, Inger; Håberg, Siri E; Magnus, Per; Steingrímsdóttir, Ólöf Anna; Strand, Bjørn Heine; Stålcrantz, Jeanette; Trogstad, Lill

2015-05-19

Vaccine against human papillomavirus (HPV) has been offered free of charge to all 12-year-old girls in Norway since 2009. Nevertheless, the uptake of HPV vaccine is lower than for other childhood vaccines. The aim of this study was to examine whether parental education and income are associated with initiation and completion of HPV vaccination. Nationwide register-based study. Publicly funded childhood immunisation programme in Norway. 91,405 girls born between 1997 and 1999 and registered in the Norwegian Central Population Registry were offered HPV vaccine during the first 3 programme years. Of these, 84,139 had complete information on all variables and were included in the study. Information on HPV-vaccination status was obtained from the Norwegian Immunisation Registry. Data on socioeconomic factors were extracted from Statistics Norway. Risk differences (RDs) and CIs were estimated with Poisson regression. In the study sample, 78.3% received at least one dose of HPV vaccine and 73.6% received all three doses. High maternal education was significantly associated with lower probability of initiating HPV vaccination (multivariable RD=-5.5% (95% CI -7.0% to -4.0%) for highest compared with lowest education level). In contrast, high maternal income was significantly associated with higher probability of initiating vaccination (multivariable RD=10.1% (95% CI 9.0% to 11.3%) for highest compared with lowest quintile). Paternal education and income showed similar, but weaker, associations. The negative association between education and initiation was only seen for incomes below the median value. In spite of the presumably equal access to HPV vaccine in Norway, we found socioeconomic disparities in vaccine uptake. More studies are needed to explain the underlying factors responsible for the observed socioeconomic differences. Insight into these factors is necessary to target information and increase vaccination coverage to ultimately reduce HPV-related disease across socioeconomic barriers. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Superfund record of decision amendment (EPA Region 5): Allied Chemical/Ironton Coke Superfund Site, Ironton, OH, July 31, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The Allied Chemical/Ironton Coke Superfund Site, located in Ironton, Lawrence County, Ohio is approximately 95 acres in size. The Allied Chemical/Ironton Coke site is divided into two operable units, the Goldcamp Disposal Area (GDA) and the Coke Plant/Lagoon Area (CPLA). The GDA Record of Decision (ROD) which describes the GDA site remedy was executed on September 29, 1988 (PB89-206221). The CPLA RD/RA is also through a CERCLA Section 106 Unilateral Administrative Order which was signed on July 1, 1991 and was issued to Allied Signal, Inc (PB92-964115). During the pre-design and design for the CPLA, new information discovered in whichmore » fundamental changes to the original CPLA and GDA ROD`s are required. This ROD Amendment documents four fundamental changes that will affect the CPLA ROD and one of the four changes that will affect the GDA ROD.« less

Healthcare resource utilization with ixazomib or placebo plus lenalidomide-dexamethasone in the randomized, double-blind, phase 3 TOURMALINE-MM1 study in relapsed/refractory multiple myeloma.

PubMed

Hari, Parameswaran; Lin, Huamao Mark; Zhu, Yanyan; Berg, Deborah; Richardson, Paul G; Moreau, Philippe

2018-05-29

The aim of this analysis was to assess healthcare resource utilization in the pivotal phase 3 TOURMALINE-MM1 study of the oral proteasome inhibitor ixazomib or placebo plus lenalidomide and dexamethasone (Rd) in relapsed and/or refractory multiple myeloma (RRMM). In this double-blind, placebo-controlled, randomized study (NCT01564537), 722 patients with RRMM following 1-3 prior lines of therapy received Rd plus ixazomib (ixazomib-Rd; n = 360) or matching placebo (placebo-Rd; n = 362) until disease progression or unacceptable toxicity. Healthcare resource utilization data were captured on Day 1 of each 28-day cycle, every 4 weeks during follow-up for progression-free survival, and every 12 weeks during subsequent follow-up, and included medical encounters (length of stay, inpatient, outpatient, and reason) and number of missing days from work or other activities for patients and caregivers. Exposure-adjusted rates of hospitalization were similar between the ixazomib-Rd and placebo-Rd arms, at 0.530 and 0.564 per patient year (ppy), respectively, as were outpatient visit rates (3.305 and 3.355 ppy). Mean length of hospitalization per patient was 10.0 and 10.8 days, respectively. In both arms, hospitalization and outpatient visit rates were higher in patients with two or three prior lines of treatment (ixazomib-Rd: 0.632 and 3.909 ppy; placebo-Rd: 0.774 and 3.539 ppy) compared with patients with one prior line (ixazomib-Rd: 0.460 and 2.888 ppy; placebo-Rd: 0.436 and 3.243 ppy). Patients and their caregivers who missed any work or other activity missed a median of 7 and 5 days in the ixazomib-Rd arm, respectively, vs 8 and 4 days with placebo-Rd. The study was not powered for a statistical comparison of healthcare resource utilization between treatment arms, nor did it capture costs associated with utilization of the identified healthcare resources. This pre-specified analysis demonstrated that the all-oral triplet regimen of ixazomib added to Rd did not increase healthcare resource utilization compared with placebo-Rd.

Survey of K-3rd-Grade Teachers' Knowledge of Ear Infections and Willingness to Participate in Prevention Programs

ERIC Educational Resources Information Center

Danhauer, Jeffrey L.; Johnson, Carole E.; Caudle, Abby T.

2011-01-01

Purpose: Ear infections are prevalent in kindergarten through 3rd-grade (K-3rd) children and can affect their performance at school. Chewing gum, when administered by parents and teachers, can help prevent ear infections in children. This pilot study surveyed K-3rd-grade teachers in the Santa Barbara School Districts to assess their knowledge…

75 FR 55313 - Record of Decision (ROD) for Conversion of the 3rd Armored Cavalry Regiment (3rd ACR) to a...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-10

... DEPARTMENT OF DEFENSE Department of the Army Record of Decision (ROD) for Conversion of the 3rd Armored Cavalry Regiment (3rd ACR) to a Stryker Brigade Combat Team (SBCT) at Fort Hood, TX AGENCY: Department of the Army, DoD. ACTION: Notice of Availability (NOA). SUMMARY: The Department of the Army...

Older, vulnerable patient view: a pilot and feasibility study of the patient measure of safety (PMOS) with patients in Australia.

PubMed

Taylor, Natalie; Hogden, Emily; Clay-Williams, Robyn; Li, Zhicheng; Lawton, Rebecca; Braithwaite, Jeffrey

2016-06-08

The UK-developed patient measure of safety (PMOS) is a validated tool which captures patient perceptions of safety in hospitals. We aimed (1) to investigate the extent to which the PMOS is appropriate for use with stroke, acute myocardial infarction (AMI) and hip fracture patients in Australian hospitals and (2) to pilot the PMOS for use in a large-scale, national study 'Deepening our Understanding of Quality in Australia' (DUQuA). Stroke, AMI and hip fracture patients (n=34) receiving care in 3 wards in 1 large hospital. 2 phases were conducted. First, a 'think aloud' study was used to determine the validity of PMOS with this population in an international setting, and to make amendments based on patient feedback. The second phase tested the revised measure to establish the internal consistency reliability of the revised subscales, and piloted the recruitment and administration processes to ensure feasibility of the PMOS for use in DUQuA. Of the 43 questions in the PMOS, 13 (30%) were amended based on issues patients highlighted for improvement in phase 1. In phase 2, a total of 34 patients were approached and 29 included, with a mean age of 71.3 years (SD=16.39). Internal consistency reliability was established using interitem correlation and Cronbach's α for all but 1 subscale. The most and least favourably rated aspects of safety differed between the 3 wards. A study log was categorised into 10 key feasibility factors, including liaising with wards to understand operational procedures and identify patterns of patient discharge. Capturing patient perceptions of care is crucial in improving patient safety. The revised PMOS is appropriate for use with vulnerable older adult groups. The findings from this study have informed key decisions made for the deployment of this measure as part of the DUQuA study. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

16 CFR 1031.3 - Consumer Product Safety Act amendments.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Consumer Product Safety Act amendments. 1031.3 Section 1031.3 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL COMMISSION... Consumer Product Safety Act amendments. The Consumer Product Safety Act, as amended, contains several...

16 CFR 1031.3 - Consumer Product Safety Act amendments.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Consumer Product Safety Act amendments. 1031.3 Section 1031.3 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL COMMISSION... Consumer Product Safety Act amendments. The Consumer Product Safety Act, as amended, contains several...

Clarithromycin (Biaxin)-lenalidomide-low-dose dexamethasone (BiRd) versus lenalidomide-low-dose dexamethasone (Rd) for newly diagnosed myeloma.

PubMed

Gay, Francesca; Rajkumar, S Vincent; Coleman, Morton; Kumar, Shaji; Mark, Tomer; Dispenzieri, Angela; Pearse, Roger; Gertz, Morie A; Leonard, John; Lacy, Martha Q; Chen-Kiang, Selina; Roy, Vivek; Jayabalan, David S; Lust, John A; Witzig, Thomas E; Fonseca, Rafael; Kyle, Robert A; Greipp, Philip R; Stewart, A Keith; Niesvizky, Ruben

2010-09-01

The objective of this case-matched study was to compare the efficacy and toxicity of the addition of clarithromycin (Biaxin) to lenalidomide/low-dose dexamethasone (BiRd) vs. lenalidomide/low-dose dexamethasone (Rd) for newly diagnosed myeloma. Data from 72 patients treated at the New York Presbyterian Hospital-Cornell Medical Center were retrospectively compared with an equal number of matched pair mates selected among patients seen at the Mayo Clinic who received Rd. Case matching was blinded and was performed according to age, gender, and transplant status. On intention-to-treat analysis, complete response (45.8% vs. 13.9%, P < 0.001) and very-good-partial-response or better (73.6% vs. 33.3%, P < 0.001) were significantly higher with BiRd. Time-to-progression (median 48.3 vs. 27.5 months, P = 0.071), and progression-free survival (median 48.3 vs. 27.5 months, P = 0.044) were higher with BiRd. There was a trend toward better OS with BiRd (3-year OS: 89.7% vs. 73.0%, P = 0.170). Main grade 3-4 toxicities of BiRd were hematological, in particular thrombocytopenia (23.6% vs. 8.3%, P = 0.012). Infections (16.7% vs. 9.7%, P = 0.218) and dermatological toxicity (12.5% vs. 4.2%, P = 0.129) were higher with Rd. Results of this case-matched analysis suggest that there is significant additive value when clarithromycin is added to Rd. Randomized phase III trials are needed to confirm these results. © 2010 Wiley-Liss, Inc.

Projected savings through public health voluntary licences of HIV drugs negotiated by the Medicines Patent Pool (MPP)

PubMed Central

Juneja, Sandeep; Gupta, Aastha; Moon, Suerie; Resch, Stephen

2017-01-01

The Medicines Patent Pool (MPP) was established in 2010 to ensure timely access to low-cost generic versions of patented antiretroviral (ARV) medicines in low- and middle-income countries (LMICs) through the negotiation of voluntary licences with patent holders. While robust data on the savings generated by MPP and other major global public health initiatives is important, it is also difficult to quantify. In this study, we estimate the savings generated by licences negotiated by the MPP for ARV medicines to treat HIV/AIDS in LMICs for the period 2010–2028 and generate a cost-benefit ratio–based on people living with HIV (PLHIVs) in any new countries which gain access to an ARV due to MPP licences and the price differential between originator’s tiered price and generics price, within the period where that ARV is patented. We found that the direct savings generated by the MPP are estimated to be USD 2.3 billion (net present value) by 2028, representing an estimated cost-benefit ratio of 1:43, which means for every USD 1 spent on MPP, the global public health community saves USD 43. The saving of USD 2.3 billion is equivalent to more than 24 million PLHIV receiving first-line ART in LMICs for 1 year at average prices today. PMID:28542239

Dizziness in Europe: from licensed fitness to drive to licence without fitness to drive.

PubMed

Huppert, Doreen; Straumann, Dominik; Magnusson, Mans; Pyykkö, Ilmari; Brandt, Thomas

2018-03-13

A common European Community driving licence was established in 1980. However, there are major differences among the countries as regards medical conditions that legally affect driving ability. This article discusses various assessment guidelines for dizzy patients. These range from a total absence of specified binding requirements in Finland or regulations open to clinical interpretation in Switzerland, to inappropriately strict regulations in Germany. We focus on requirements for patients with vestibular disorders in Germany which have been in force since 2014. These guidelines stipulate that for group 1 driving licence (private cars < 3.5 t, motorbikes): (1) patients with Menière's disease (attacks without prodromes) must have had no attacks for 2 years before it is possible to drive again. (2) Patients with vestibular migraine without prodromes must not have had any attacks for 3 years. For a group 1 and group 2 driving licence ("professional driver"): (3) patients with bilateral vestibulopathy as a rule are considered to have a driving disability. Similarly, strict restrictions have been formulated for ocular motor disorders such as downbeat and upbeat nystagmus and for patients with functional (psychosomatic) forms of dizziness such as phobic postural vertigo. The authors represent a working group of the European Dizzynet focusing on the topic "fitness to drive with vertigo and balance disorders". They agree that European guidelines must be revised and harmonized, for some are too strict and the required dizziness-free intervals are too long; others must be revised, for they are too lax. A common European standard is needed.

Experts' opinion about the primary headache diagnostic criteria of the ICHD-3rd edition beta in children and adolescents.

PubMed

Özge, Aynur; Faedda, Noemi; Abu-Arafeh, Ishaq; Gelfand, Amy A; Goadsby, Peter James; Cuvellier, Jean Christophe; Valeriani, Massimiliano; Sergeev, Alexey; Barlow, Karen; Uludüz, Derya; Yalın, Osman Özgür; Lipton, Richard B; Rapoport, Alan; Guidetti, Vincenzo

2017-11-23

The 2013 International Classification of Headache Disorders-3 (ICHD-3) was published in a beta version to allow the clinicians to confirm the validity of the criteria or to suggest improvements based on field studies. The aim of this work was to review the Primary Headache Disorders Section of ICHD-3 beta data on children and adolescents (age 0-18 years), and to suggest changes, additions, and amendments. Several experts in childhood headache across the world applied different aspects of ICHD-3 beta in their normal clinical practice. Based on their personal experience and the literature available on pediatric headache, they made observations and proposed suggestions for the primary headache disorders section of ICHD-3 beta data on children and adolescents. Some headache disorders in children have specific features which are different from those seen in adults and which should be acknowledged and considered. Some features in children were found to be age-dependent: clinical characteristics, risks factors and etiologies have a strong bio psycho-social basis in children and adolescents making primary headache disorders in children distinct from those in adults. Several recommendations are presented in order to make ICHD-3 more appropriate for use with children.

An Evidence-Based Approach to Estimating the National and State Costs of PreK-3rd. FCD Policy Brief Advancing PK-3rd. No.10

ERIC Educational Resources Information Center

Picus, Lawrence O.; Odden, Allan; Goetz, Michael

2009-01-01

This study estimates the costs of providing a high-quality PreK-3rd education approach in all 50 states plus the District of Columbia. Relying on an Evidence-Based approach to school finance adequacy, it identifies the staffing resources needed to offer high-quality integrated PreK-3rd programs and then estimates the costs of those resources. By…

Outcome prediction of third ventriculostomy: a proposed hydrocephalus grading system.

PubMed

Kehler, U; Regelsberger, J; Gliemroth, J; Westphal, M

2006-08-01

An important factor in making a recommendation for different treatment modalities in hydrocephalus patients (VP shunt versus endoscopic third ventriculostomy) is the definition of the underlying pathology which determines the prognosis/outcome of the surgical procedure. Third ventriculostomies (3rd VS) are successful mainly in obstructive hydrocephalus but also in some subtypes of communicating hydrocephalus. A simple, easily applicable grading system that is designed to predict the outcome of 3rd VS is proposed. The hydrocephalus is graded on the basis of the extent of downward bulging of the floor of the third ventricle, which reflects the pressure gradient between the 3rd ventricle and the basal cisterns, presence of directly visualised CSF pathway obstruction in MRI, and the progression of the clinical symptoms resulting in five different grades. In this proposed grading system, grade 1 hydrocephalus subtype shows no downward bulged floor of the 3rd ventricle, no obstruction of the CSF pathway, and no progressive symptoms of hydrocephalus. There is no indication for 3rd VS. Grades 2 to 4 show different combinations of the described parameters. Grade 5 subtype shows a markedly downward bulged floor of the 3rd ventricle and direct detection of the CSF pathway obstruction (i.e., aqueductal stenosis) with progressive clinical deterioration. Retrospective application of this grading scheme to a series of 72 3rd VS has demonstrated a high correlation with the outcome: The success rate in grade 3 reached 40%, in grade 4: 58%, and in grade 5: 95%. This standardised grading system predicts the outcome of 3rd VS and helps in decision making for 3rd VS versus VP shunting.

Characterization of the HLA-DRβ1 third hypervariable region amino acid sequence according to charge and parental inheritance in systemic sclerosis.

PubMed

Gentil, Coline A; Gammill, Hilary S; Luu, Christine T; Mayes, Maureen D; Furst, Dan E; Nelson, J Lee

2017-03-07

Specific HLA class II alleles are associated with systemic sclerosis (SSc) risk, clinical characteristics, and autoantibodies. HLA nomenclature initially developed with antibodies as typing reagents defining DRB1 allele groups. However, alleles from different DRB1 allele groups encode the same third hypervariable region (3rd HVR) sequence, the primary T-cell recognition site, and 3rd HVR charge differences can affect interactions with T cells. We considered 3rd HVR sequences (amino acids 67-74) irrespective of the allele group and analyzed parental inheritance considered according to the 3rd HVR charge, comparing SSc patients with controls. In total, 306 families (121 SSc and 185 controls) were HLA genotyped and parental HLA-haplotype origin was determined. Analysis was conducted according to DRβ1 3rd HVR sequence, charge, and parental inheritance. The distribution of 3rd HVR sequences differed in SSc patients versus controls (p = 0.007), primarily due to an increase of specific DRB1*11 alleles, in accord with previous observations. The 3rd HVR sequences were next analyzed according to charge and parental inheritance. Paternal transmission of DRB1 alleles encoding a +2 charge 3rd HVR was significantly reduced in SSc patients compared with maternal transmission (p = 0.0003, corrected for analysis of four charge categories p = 0.001). To a lesser extent, paternal transmission was increased when charge was 0 (p = 0.021, corrected for multiple comparisons p = 0.084). In contrast, paternal versus maternal inheritance was similar in controls. SSc patients differed from controls when DRB1 alleles were categorized according to 3rd HVR sequences. Skewed parental inheritance was observed in SSc patients but not in controls when the DRβ1 3rd HVR was considered according to charge. These observations suggest that epigenetic modulation of HLA merits investigation in SSc.

Legislation to regulate medical devices.

PubMed

Harris, M

1975-01-01

The history of medical device regulation began with the need to rid the marketplace of bogus inventions which were either harmful in themselves or harmful because they delayed meaningful treatment of illness. Since World War II, sophistication in medical technology and development of electronic and other types of medical devices has created a new need for regulation of safety and performance of devices used to cure and mitigate disease in man. The 1938 amendments to the Food, Drug, and Cosmetic Act gave FDA authority over labeling and advertising of devices, enforceable only after devices were marketed. In 1969 a study by an HEW commission documented the need for further legislation. The commission recommended three categories of medical devices: those requiring premarket clearance or scientific review, those for which standards could be established to protect the public, and those which are generally recognized as safe and for which nor standards would be necessary. In 1974 the Senate unanimously approved Senator Kennedy's "Medical Device Amendments of 1973" legislation which fulfills the recommendations of the HEW commission report. The House of Representatives failed to pass their version of the legislation in the 93rd Congress. Senator Kennedy re-introduced the bill in the 94th Congress and it passed the Senate in April 1975. Representative Rogers re-introduced an amended bill. The bill is expected to become law in 1975.

3 CFR - Eligibility of the Economic Community of Central African States To Receive Defense Articles and...

Code of Federal Regulations, 2010 CFR

2010-01-01

..., as Amended, and the Arms Export Control Act, as Amended Presidential Documents Other Presidential... Assistance Act of 1961, as Amended, and the Arms Export Control Act, as Amended Memorandum for the Secretary..., including section 503(a) of the Foreign Assistance Act of 1961, as amended, and section 3(a)(1) of the Arms...

Effects of soil amendment on soil characteristics and maize yield in Horqin Sandy Land

NASA Astrophysics Data System (ADS)

Zhou, L.; Liu, J. H.; Zhao, B. P.; Xue, A.; Hao, G. C.

2016-08-01

A 4-year experiment was conducted to investigate the inter-annual effects of sandy soil amendment on maize yield, soil water storage and soil enzymatic activities in sandy soil in Northeast China in 2010 to 2014. We applied the sandy soil amendment in different year, and investigated the different effects of sandy soil amendment in 2014. There were six treatments including: (1) no sandy soil amendment application (CK); (2) one year after applying sandy soil amendment (T1); (3) two years after applying sandy soil amendment(T2); (4) three years after applying sandy soil amendment(T3); (5)four years after applying sandy soil amendment(T4); (6) five years after applying sandy soil amendment (T5). T refers to treatment, and the number refers to the year after application of the sandy soil amendment. Comparing with CK, sandy soil amendments improved the soil water storage, soil urease, invertase, and catalase activity in different growth stages and soil layers, the order of soil water storage in all treatments roughly performed: T3 > T5 > T4 > T2 > T1 > CK. the order of soil urease, invertase, and catalase activity in all treatments roughly performed: T5 > T3 > T4 > T2 > T1 > CK. Soil application of sandy soil amendment significantly (p≤⃒0.05) increased the grain yield and biomass yield by 22.75%-41.42% and 29.92%-45.45% respectively, and maize yield gradually increased with the years go by in the following five years. Sandy soil amendment used in poor sandy soil had a positive effect on soil water storage, soil enzymatic activities and maize yield, after five years applied sandy soil amendment (T5) showed the best effects among all the treatments, and deserves further research.

Research and Development Productivity in the USSR. Causes of Decline Since the 1960’s and Prospects for the 1980’s

DTIC Science & Technology

1987-03-23

Feminization of R&D personnel ..... .. 210 11.3.2.1 Productivity of women in R&D. 210 11.3.2.2 The share of women in R&D. 212 Chapter 12. Expanding R&D on the...I Changes in the share of women in the higher tiers of scientific hierarchy are of particular importance for judging the impact of feminization ... Feminization must have occurred primarily in higher education, the least important sector of R&D. The share of women among all R&D employees increased

Genomic Variability of Mycobacterium tuberculosis Strains of the Euro-American Lineage Based on Large Sequence Deletions and 15-Locus MIRU-VNTR Polymorphism

PubMed Central

Rindi, Laura; Medici, Chiara; Bimbi, Nicola; Buzzigoli, Andrea; Lari, Nicoletta; Garzelli, Carlo

2014-01-01

A sample of 260 Mycobacterium tuberculosis strains assigned to the Euro-American family was studied to identify phylogenetically informative genomic regions of difference (RD). Mutually exclusive deletions of regions RD115, RD122, RD174, RD182, RD183, RD193, RD219, RD726 and RD761 were found in 202 strains; the RDRio deletion was detected exclusively among the RD174-deleted strains. Although certain deletions were found more frequently in certain spoligotype families (i.e., deletion RD115 in T and LAM, RD174 in LAM, RD182 in Haarlem, RD219 in T and RD726 in the “Cameroon” family), the RD-defined sublineages did not specifically match with spoligotype-defined families, thus arguing against the use of spoligotyping for establishing exact phylogenetic relationships between strains. Notably, when tested for katG463/gyrA95 polymorphism, all the RD-defined sublineages belonged to Principal Genotypic Group (PGG) 2, except sublineage RD219 exclusively belonging to PGG3; the 58 Euro-American strains with no deletion were of either PGG2 or 3. A representative sample of 197 isolates was then analyzed by standard 15-locus MIRU-VNTR typing, a suitable approach to independently assess genetic relationships among the strains. Analysis of the MIRU-VNTR typing results by using a minimum spanning tree (MST) and a classical dendrogram showed groupings that were largely concordant with those obtained by RD-based analysis. Isolates of a given RD profile show, in addition to closely related MIRU-VNTR profiles, related spoligotype profiles that can serve as a basis for better spoligotype-based classification. PMID:25197794

26 CFR 1.411(d)-3 - Section 411(d)(6) protected benefits.

Code of Federal Regulations, 2013 CFR

2013-04-01

... amendments with the same applicable amendment date are treated as one amendment. Thus, if two amendments have the same applicable amendment date and one amendment, standing alone, increases participants' accrued... are treated as one amendment and will only violate section 411(d)(6) if, for any participant, the net...

Third-line therapy in recurrent glioblastoma: is it another chance for bevacizumab?

PubMed

Franceschi, Enrico; Lamberti, Giuseppe; Paccapelo, Alexandro; Di Battista, Monica; Genestreti, Giovenzio; Minichillo, Santino; Mura, Antonella; Bartolini, Stefania; Agati, Raffaele; Brandes, Alba A

2018-04-18

Standard glioblastoma therapy is long-lasting. Among second-line therapy, choices could be bevacizumab and nitrosoureas depending on National Agencies approval. There is no consensus on 3rd line therapy or clinical trials specifically designed for this setting. We reviewed our institutional database on all consecutive patients who received 3rd line therapy for glioblastoma. Data on 168 out of 1337 (12.6%) glioblastoma patients who underwent 3rd line therapy treatment were collected. Third line treatments were bevacizumab or chemotherapy (nitrosourea, temozolomide or carboplatin plus etoposide). Median progression free survival was 2.9 months and median survival time was 6.6 months from the start of 3rd line therapy. Bevacizumab significantly improved progression-free survival (4.7 vs. 2.6 months, p = .020) and survival from 3rd line start (8.0 vs. 6.0 months, p = .014) in respect to chemotherapy. Toxicity of grade ≥ 3 occurred in 13.7% of patients. In multivariate analysis, survival in 3rd line treatment depends on MGMT methylation (p = .006) and treatment with Bevacizumab (p = .011). Third line therapy in selected glioblastoma patients may be feasible and well tolerated. Bevacizumab improved outcome in 3rd line in respect to chemotherapy.

Draft EU regulation on paediatric medicines: some improvements but still far from perfect.

PubMed

2006-02-01

(1) In 2004, the European Commission proposed a draft European Regulation on paediatric medicines. This draft was more closely oriented towards defending drug companies' interests than with meeting children's medical needs. (2) Despite pressure from drug companies and their allies, several major improvements were made to the draft at its first reading in the European Parliament, thanks especially to the efforts of the Medicines in Europe Forum. (3) In particular, European deputies pushed for a better definition of children's needs and paediatric research priorities, greater transparency at various important stages of the market authorization procedure, and strengthened pharmacovigilance. (4) Yet the incentives and rewards offered to companies fail to take into account the notion of true therapeutic advantages and R&D expenditure. (5) Unfortunately the Commission refused some important amendments and published a new draft proposal, which was accepted by the Council of Health Ministers at the end of 2005. The new draft will come before the Parliament for a second reading in 2006.

Does alcohol outlet density differ by area-level disadvantage in metropolitan Perth?

PubMed

Foster, Sarah; Hooper, Paula; Knuiman, Matthew; Trapp, Georgina; Wood, Lisa

2017-09-01

Research suggests that there are area-level disparities in alcohol outlets, with greater density in disadvantaged areas. In part, this might be explained by the inequitable distribution of retail, attracted by lower rents to disadvantaged neighbourhoods. This ecological study examines the distribution of liquor licences in Perth, Australia, and whether discrepancies in the distribution of retail land-uses could account for a socio-economic gradient. Area disadvantage was determined for each Statistical Area 1 (SA1) using the Australian Bureau of Statistics Index of Relative Socio-economic Disadvantage, and licence locations were mapped in GIS. Negative binomial loglinear models examined whether licence densities within SA1s differed by area disadvantage, controlling for demographics and spatial correlation. Models included an offset term, so the estimated effects of area-level disadvantage were on licences per km 2 , or licences per retail destination. In the area-based analyses, for every unit increase in disadvantage decile (i.e. a reduction in relative disadvantage), general licences reduced by 15% (P = 0.000) and liquor stores reduced by 7% (P = 0.004). These gradients were not apparent when licences were examined as a function of retail; however, for every unit increase in disadvantage decile, the density of on-premise licences per retail destination increased by 14% (P = 0.000). The direction of the socio-economic gradient for general licences and liquor stores in Perth is concerning, as all licences selling packaged alcohol were more abundant in disadvantaged areas. However, the over-representation of packaged liquor in disadvantaged areas may relate to the increased provision of retail. © 2017 Australasian Professional Society on Alcohol and other Drugs.

41 CFR 102-3.80 - How are minor charter amendments accomplished?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false How are minor charter... are minor charter amendments accomplished? (a) Responsibility and limitation. The agency head is responsible for amending the charter of an advisory committee. Amendments may be either minor or major. The...

41 CFR 102-3.80 - How are minor charter amendments accomplished?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false How are minor charter... are minor charter amendments accomplished? (a) Responsibility and limitation. The agency head is responsible for amending the charter of an advisory committee. Amendments may be either minor or major. The...

14 CFR 139.205 - Amendment of Airport Certification Manual.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Amendment of Airport Certification Manual... CERTIFICATION OF AIRPORTS Airport Certification Manual § 139.205 Amendment of Airport Certification Manual. (a) Under § 139.3, the Regional Airports Division Manager may amend any Airport Certification Manual...

14 CFR 139.205 - Amendment of Airport Certification Manual.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Amendment of Airport Certification Manual... CERTIFICATION OF AIRPORTS Airport Certification Manual § 139.205 Amendment of Airport Certification Manual. (a) Under § 139.3, the Regional Airports Division Manager may amend any Airport Certification Manual...

14 CFR 139.205 - Amendment of Airport Certification Manual.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Amendment of Airport Certification Manual... CERTIFICATION OF AIRPORTS Airport Certification Manual § 139.205 Amendment of Airport Certification Manual. (a) Under § 139.3, the Regional Airports Division Manager may amend any Airport Certification Manual...

14 CFR 139.205 - Amendment of Airport Certification Manual.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Amendment of Airport Certification Manual... CERTIFICATION OF AIRPORTS Airport Certification Manual § 139.205 Amendment of Airport Certification Manual. (a) Under § 139.3, the Regional Airports Division Manager may amend any Airport Certification Manual...

Evaluation of the work of hospital districts' research ethics committees in Finland.

PubMed

Halila, Ritva

2014-12-01

The main task of research ethics committees (RECs) is to assess research studies before their start. In this study, 24 RECs that evaluate medical research were sent questionnaires about their structure and functions. The RECs were divided into two separate groups: those working in university hospital districts (uRECs) and those in central hospital districts (non-uRECs). The two groups were different in many respects: the uRECs were bigger in size, covered a wider range of disciplines (both medical and non-medical), had better resources and more frequent and regular meetings. After the survey was performed and analysed, the Medical Research Act was amended so that only hospital districts with a medical faculty in their region had a duty to establish ethics committees. After the amendment, the number of RECs evaluating medical research in Finland decreased from 25 to 9. The ethics committees that remained had wider expertise and were better equipped already by the time of this survey. Only one non-uREC was continuing its work, and this was being done under the governance of a university hospital district. Simple measures were used for qualitative analysis of the work of RECs that evaluate medical research. These showed differences between RECs. This may be helpful in establishing an ethics committee network in a research field or administrational area. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

High precision series solutions of differential equations: Ordinary and regular singular points of second order ODEs

NASA Astrophysics Data System (ADS)

Noreen, Amna; Olaussen, Kåre

2012-10-01

A subroutine for a very-high-precision numerical solution of a class of ordinary differential equations is provided. For a given evaluation point and equation parameters the memory requirement scales linearly with precision P, and the number of algebraic operations scales roughly linearly with P when P becomes sufficiently large. We discuss results from extensive tests of the code, and how one, for a given evaluation point and equation parameters, may estimate precision loss and computing time in advance. Program summary Program title: seriesSolveOde1 Catalogue identifier: AEMW_v1_0 Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AEMW_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 991 No. of bytes in distributed program, including test data, etc.: 488116 Distribution format: tar.gz Programming language: C++ Computer: PC's or higher performance computers. Operating system: Linux and MacOS RAM: Few to many megabytes (problem dependent). Classification: 2.7, 4.3 External routines: CLN — Class Library for Numbers [1] built with the GNU MP library [2], and GSL — GNU Scientific Library [3] (only for time measurements). Nature of problem: The differential equation -s2({d2}/{dz2}+{1-ν+-ν-}/{z}{d}/{dz}+{ν+ν-}/{z2})ψ(z)+{1}/{z} ∑n=0N vnznψ(z)=0, is solved numerically to very high precision. The evaluation point z and some or all of the equation parameters may be complex numbers; some or all of them may be represented exactly in terms of rational numbers. Solution method: The solution ψ(z), and optionally ψ'(z), is evaluated at the point z by executing the recursion A(z)={s-2}/{(m+1+ν-ν+)(m+1+ν-ν-)} ∑n=0N Vn(z)A(z), ψ(z)=ψ(z)+A(z), to sufficiently large m. Here ν is either ν+ or ν-, and Vn(z)=vnz. The recursion is initialized by A(z)=δzν,for n=0,1,…,N ψ(z)=A0(z). Restrictions: No solution is computed if z=0, or s=0, or if ν=ν- (assuming Reν+≥Reν-) with ν+-ν- an integer, except when ν+-ν-=1 and v =0 (i.e. when z is an ordinary point for zψ(z)). Additional comments: The code of the main algorithm is in the file seriesSolveOde1.cc, which "#include" the file checkForBreakOde1.cc. These routines, and the programs using them, must "#include" the file seriesSolveOde1.cc. Running time: On a Linux PC that is a few years old, at y=√{10} to an accuracy of P=200 decimal digits, evaluating the ground state wavefunction of the anharmonic oscillator (with the eigenvalue known in advance); (cf. Eq. (6)) takes about 2 ms, and about 40 min at an accuracy of P=100000 decimal digits. References: [1] B. Haible and R.B. Kreckel, CLN — Class Library for Numbers, http://www.ginac.de/CLN/ [2] T. Granlund and collaborators, GMP — The GNU Multiple Precision Arithmetic Library, http://gmplib.org/ [3] M. Galassi et al., GNU Scientific Library Reference Manual (3rd Ed.), ISBN 0954612078., http://www.gnu.org/software/gsl/

26 CFR 1.411(d)-3 - Section 411(d)(6) protected benefits.

Code of Federal Regulations, 2010 CFR

2010-04-01

... to years of service and compensation. (ii) Amendments effective with the same applicable amendment... age (age 65). Plan A is amended on November 1, 2006, effective as of January 1, 2007, to provide for... payable under the minimum provision, approximately 3 years after the amendment becomes effective). Example...

47 CFR 3.27 - Amended application.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Amended application. 3.27 Section 3.27 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL AUTHORIZATION AND ADMINISTRATION OF ACCOUNTING... incomplete and that could affect the approval process, require the submission of an amended application. The...

Third-generation CD28/4-1BB chimeric antigen receptor T cells for chemotherapy relapsed or refractory acute lymphoblastic leukaemia: a non-randomised, open-label phase I trial protocol.

PubMed

Tang, Xiao-Yi; Sun, Yao; Zhang, Ang; Hu, Guo-Liang; Cao, Wei; Wang, Dan-Hong; Zhang, Bin; Chen, Hu

2016-12-30

There is no curative treatment available for patients with chemotherapy relapsed or refractory CD19+ B cells-derived acute lymphoblastic leukaemia (r/r B-ALL). Although CD19-targeting second-generation (2nd-G) chimeric antigen receptor (CAR)-modified T cells carrying CD28 or 4-1BB domains have demonstrated potency in patients with advanced B-ALL, these 2 signalling domains endow CAR-T cells with different and complementary functional properties. Preclinical results have shown that third-generation (3rd-G) CAR-T cells combining 4-1BB and CD28 signalling domains have superior activation and proliferation capacity compared with 2nd-G CAR-T cells carrying CD28 domain. The aim of the current study is therefore to investigate the safety and efficacy of 3rd-G CAR-T cells in adults with r/r B-ALL. This study is a phase I clinical trial for patients with r/r B-ALL to test the safety and preliminary efficacy of 3rd-G CAR-T cells. Before receiving lymphodepleting conditioning regimen, the peripheral blood mononuclear cells from eligible patients will be leukapheresed, and the T cells will be purified, activated, transduced and expanded ex vivo. On day 6 in the protocol, a single dose of 1 million CAR-T cells per kg will be administrated intravenously. The phenotypes of infused CAR-T cells, copy number of CAR transgene and plasma cytokines will be assayed for 2 years after CAR-T infusion using flow cytometry, real-time quantitative PCR and cytometric bead array, respectively. Moreover, several predictive plasma cytokines including interferon-γ, interleukin (IL)-6, IL-8, Soluble Interleukin (sIL)-2R-α, solubleglycoprotein (sgp)130, sIL-6R, Monocyte chemoattractant protein (MCP1), Macrophage inflammatory protein (MIP1)-α, MIP1-β and Granulocyte-macrophage colony-stimulating factor (GM-CSF), which are highly associated with severe cytokine release syndrome (CRS), will be used to forecast CRS to allow doing earlier intervention, and CRS will be managed based on a revised CRS grading system. In addition, patients with grade 3 or 4 neurotoxicities or persistent B-cell aplasia will be treated with dexamethasone (10 mg intravenously every 6 hours) or IgG, respectively. Descriptive and analytical analyses will be performed. Ethical approval for the study was granted on 10 July 2014 (YLJS-2014-7-10). Written informed consent will be taken from all participants. The results of the study will be reported, through peer-reviewed journals, conference presentations and an internal organisational report. NCT02186860. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

17 CFR 270.0-3 - Amendments to registration statements and reports.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Amendments to registration statements and reports. 270.0-3 Section 270.0-3 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) RULES AND REGULATIONS, INVESTMENT COMPANY ACT OF 1940 § 270.0-3 Amendments to...

78 FR 59080 - Audit and Financial Management Advisory Committee (AFMAC)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-25

... Administration, 409 3rd Street SW., Office of the Chief Financial Officer Conference Room, 6th Floor, Washington.... Jonathan Carver, Chief Financial Officer, 409 3rd Street SW., 6th Floor, Washington, DC 20416, phone: (202...-1608, email: [email protected] ; SBA, Office of Chief Financial Officer, 409 3rd Street SW...

25 CFR 522.3 - Amendment.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false Amendment. 522.3 Section 522.3 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR APPROVAL OF CLASS II AND CLASS III ORDINANCES AND RESOLUTIONS SUBMISSION OF GAMING ORDINANCE OR RESOLUTION § 522.3 Amendment. (a) Within 15 days after adoption...

How do user experiences with different transport modes affect the risk of traffic accidents? From the viewpoint of licence possession status.

PubMed

Nakai, Hiroshi; Usui, Shinnosuke

2017-02-01

Road accidents between different modes of transport-such as between automobiles and pedestrians, automobiles and bicycles, or automobiles and motorcycles-are frequent. In such cases, it is important to consider the other side's perspective. This involves the ability to correctly judge, for every given situation, how other people on the road perceive their surroundings and what they intend to do next. In this paper, we conduct two types of studies assuming that this kind of ability to consider perspectives is higher when the person is licenced to drive the mode of transport used by the other party. For Study 1, we analysed accidents involving senior citizens between the ages of 65 and 74 years, who collided with automobiles as pedestrians or cyclists (1656 and 3192 cases respectively), in terms of the accident category and type of road at the accident spot. The results indicate that possession or non-possession of a licence was irrelevant for accidents involving cyclists, but for accidents with pedestrians, senior citizens who did not possess a licence are likely to be involved in a greater number of accidents in places that require interaction with automobiles, such as while crossing at crosswalks or at intersections. For Study 2, we reviewed 875 ordinary first-class licence practical test examinees, categorised them according to their licence possession status (motorcycle licence, moped licence, or no licence), and made a category-wise comparison of the test instructor's assessment of their ability to make a left turn. The results showed that those who had a motorcycle or moped licence tended to make a left turn more safely. Thus, the results indicate that experience with different modes of transport is likely to reduce the risk of accidents. These findings may be used to popularise educational interventions encouraging users of various transport modes to consider the perspective of others (i.e. via perspective-taking). Copyright © 2016 Elsevier Ltd. All rights reserved.

More States Retaining 3rd Graders

ERIC Educational Resources Information Center

Robelen, Erik W.

2012-01-01

As increasing numbers of states move to end social promotion of 3rd graders, some are also including interventions to help students learn to read. Oklahoma is one of several states that recently adopted new reading policies that--with limited exceptions--call for 3rd graders to be held back if they flunk a state standardized test. Supporters say…

Effects of licence change on prescribing and poisons enquiries for antipsychotic agents in England and Scotland

PubMed Central

Bateman, D N; Good, A M; Afshari, R; Kelly, C A

2003-01-01

Aims To examine the effect of licence change for thioridazine at the end of 2000 on the prescription of antipsychotic drugs in England and Scotland, and investigate changes in poisons information inquiries and, for Edinburgh, poisons admissions. Methods Prescription data for antipsychotic drugs were obtained for England and Scotland and quarterly trends examined for 2000 and 2001. Accesses to the UK National Poisons Information Service website TOXBASE for antipsychotic products were examined for the same period. For Scotland telephone enquiry data, and admission data to the Edinburgh Poisons Unit were also evaluated. Trends in poisonings were compared with prescribing change. Results In England prescriptions for thioridazine fell rapidly in 2001 from approximately 35% of market share to less than 5%, and were replaced by risperidone, chlorpromazine and olanzapine. TOXBASE accesses fell from 39.3% of antipsychotics to 4.4%. Accesses for chlorpromazine, olanzapine and risperidone increased. In Scotland prescribing of thioridazine was similar to changes in England, but it was principally replaced by chlorpromazine. These changes were mirrored by TOXBASE accesses, telephone enquiries and in-patient admissions. The ratio of TOXBASE accesses for thioridazine to prescription numbers for the drug increased after the licence change. Conclusions Licence change produced rapid change in prescribing behaviour within 3 months. Prescribing behaviour in England and Scotland was different. Changes in prescribing were mirrored by changes in accesses for poisons information in both England and Scotland, and in Edinburgh by hospital admissions. The increase in the ratio of TOXBASE accesses to prescriptions for thioridazine suggests doctors may have become more aware of its potential toxicity. PMID:12814455

Prospective Evaluation of Prior Image Constrained Compressed Sensing (PICCS) Algorithm in Abdominal CT: A comparison of reduced dose with standard dose imaging

PubMed Central

Lubner, Meghan G.; Pickhardt, Perry J.; Kim, David H.; Tang, Jie; Munoz del Rio, Alejandro; Chen, Guang-Hong

2014-01-01

Purpose To prospectively study CT dose reduction using the “prior image constrained compressed sensing” (PICCS) reconstruction technique. Methods Immediately following routine standard dose (SD) abdominal MDCT, 50 patients (mean age, 57.7 years; mean BMI, 28.8) underwent a second reduced-dose (RD) scan (targeted dose reduction, 70-90%). DLP, CTDIvol and SSDE were compared. Several reconstruction algorithms (FBP, ASIR, and PICCS) were applied to the RD series. SD images with FBP served as reference standard. Two blinded readers evaluated each series for subjective image quality and focal lesion detection. Results Mean DLP, CTDIvol, and SSDE for RD series was 140.3 mGy*cm (median 79.4), 3.7 mGy (median 1.8), and 4.2 mGy (median 2.3) compared with 493.7 mGy*cm (median 345.8), 12.9 mGy (median 7.9 mGy) and 14.6 mGy (median 10.1) for SD series, respectively. Mean effective patient diameter was 30.1 cm (median 30), which translates to a mean SSDE reduction of 72% (p<0.001). RD-PICCS image quality score was 2.8±0.5, improved over the RD-FBP (1.7±0.7) and RD-ASIR(1.9±0.8)(p<0.001), but lower than SD (3.5±0.5)(p<0.001). Readers detected 81% (184/228) of focal lesions on RD-PICCS series, versus 67% (153/228) and 65% (149/228) for RD-FBP and RD-ASIR, respectively. Mean image noise was significantly reduced on RD-PICCS series (13.9 HU) compared with RD-FBP (57.2) and RD-ASIR (44.1) (p<0.001). Conclusion PICCS allows for marked dose reduction at abdominal CT with improved image quality and diagnostic performance over reduced-dose FBP and ASIR. Further study is needed to determine indication-specific dose reduction levels that preserve acceptable diagnostic accuracy relative to higher-dose protocols. PMID:24943136

3 CFR - Eligibility of the Maldives to Receive Defense Articles and Defense Services Under the Foreign...

Code of Federal Regulations, 2010 CFR

2010-01-01

... Articles and Defense Services Under the Foreign Assistance Act of 1961, as Amended, and the Arms Export... Services Under the Foreign Assistance Act of 1961, as Amended, and the Arms Export Control Act, as Amended... section 3(a)(1) of the Arms Export Control Act, as amended, I hereby find that the furnishing of defense...

Utilization of Concurrent Buffers to Facilitate Seamless Data Transition in Tactical Cellular Communications

DTIC Science & Technology

2015-09-01

INTENTIONALLY LEFT BLANK xiii LIST OF ACRONYMS AND ABBREVIATIONS 2G 2nd Generation 3G 3rd Generation 3GPP 3rd Generation Partnership Project 4G 4th...System (UMTS) is the standard that governs 3rd Generation ( 3G ) migration of Global Services for Mobile (GSM) networks. It defines packet-based...network may assist or mitigate. 14. SUBJECT TERMS IEEE, 802.21, Media Independent Handover, mobile , communications, cyber, tactical, buffer, cellular

Assessing the stability in dry mycelial fertilizer of Penicillium chrysogenum as soil amendment via fluorescence excitation-emission matrix spectra: organic matter's transformation and maturity.

PubMed

Wang, Bing; Cai, Chen; Li, Guomin; Liu, Huiling

2017-12-01

Utilization as dry mycelial fertilizer (DMF) produced from penicillin fermentation fungi mycelium (PFFM) with an acid-heating pretreatment is a potential way. To study the transformation and stability of water-extractable organic matter in DMF-amended soil via fluorescence regional integration (FRI) of fluorescence excitation-emission matrix (EEM), a soil experiment in pot was carried out. The results showed that residual penicillin (about 32 mg/kg) was almost degraded in the first 5 days, indicating that the drug pollution was in control. The pH value, DOC, DON, and DOC/DON presented a classical profile, but germination index (GI) leveled off about 0.13 till day 13 in DMF-12% treatment due to the severe phytotoxicity. The addition of DMF significantly increased the soil microbial populations in contrast to the CON treatment. The EEM showed that the protein-like and microbial byproduct-like matters vanished on the 25th and 33rd days, whereas the fulvic-like substances appeared on the 7th day. The humic-like substances existed in original samples but their content greatly enhanced finally. The FRI results showed that P V, n /P III, n reached the highest value of 1.84 on the 25th day, suggesting that DMF maintained stable in amended soil. Because of its consistency with the results of GI and DOC/DON, the EEM-FRI has a potential to evaluate the stability of DMF in soil.

75 FR 77745 - Federal Acquisition Regulation; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-13

... purposes of updating. List of Subjects in 48 CFR Parts 3, 5, 7, and 10 Government procurement. Dated... [Amended] 0 2. Amend section 3.104-1 by removing from the definition ``Federal agency procurement,'' in the...

Final analysis of survival outcomes in the phase 3 FIRST trial of up-front treatment for multiple myeloma.

PubMed

Facon, Thierry; Dimopoulos, Meletios A; Dispenzieri, Angela; Catalano, John V; Belch, Andrew; Cavo, Michele; Pinto, Antonello; Weisel, Katja; Ludwig, Heinz; Bahlis, Nizar J; Banos, Anne; Tiab, Mourad; Delforge, Michel; Cavenagh, Jamie D; Geraldes, Catarina; Lee, Je-Jung; Chen, Christine; Oriol, Albert; De La Rubia, Javier; White, Darrell; Binder, Daniel; Lu, Jin; Anderson, Kenneth C; Moreau, Philippe; Attal, Michel; Perrot, Aurore; Arnulf, Bertrand; Qiu, Lugui; Roussel, Murielle; Boyle, Eileen; Manier, Salomon; Mohty, Mohamad; Avet-Loiseau, Herve; Leleu, Xavier; Ervin-Haynes, Annette; Chen, Guang; Houck, Vanessa; Benboubker, Lotfi; Hulin, Cyrille

2018-01-18

This FIRST trial final analysis examined survival outcomes in patients with transplant-ineligible newly diagnosed multiple myeloma (NDMM) treated with lenalidomide and low-dose dexamethasone until disease progression (Rd continuous), Rd for 72 weeks (18 cycles; Rd18), or melphalan, prednisone, and thalidomide (MPT; 72 weeks). The primary endpoint was progression-free survival (PFS; primary comparison: Rd continuous vs MPT). Overall survival (OS) was a key secondary endpoint (final analysis prespecified ≥60 months' follow-up). Patients were randomized to Rd continuous (n = 535), Rd18 (n = 541), or MPT (n = 547). At a median follow-up of 67 months, PFS was significantly longer with Rd continuous vs MPT (hazard ratio [HR], 0.69; 95% confidence interval [CI], 0.59-0.79; P < .00001) and was similarly extended vs Rd18. Median OS was 10 months longer with Rd continuous vs MPT (59.1 vs 49.1 months; HR, 0.78; 95% CI, 0.67-0.92; P = .0023), and similar with Rd18 (62.3 months). In patients achieving complete or very good partial responses, Rd continuous had an ≈30-month longer median time to next treatment vs Rd18 (69.5 vs 39.9 months). Over half of all patients who received second-line treatment were given a bortezomib-based therapy. Second-line outcomes were improved in patients receiving bortezomib after Rd continuous and Rd18 vs after MPT. No new safety concerns, including risk for secondary malignancies, were observed. Treatment with Rd continuous significantly improved survival outcomes vs MPT, supporting Rd continuous as a standard of care for patients with transplant-ineligible NDMM. This trial was registered at www.clinicaltrials.gov as #NCT00689936 and EudraCT as 2007-004823-39. © 2018 by The American Society of Hematology.

Final analysis of survival outcomes in the phase 3 FIRST trial of up-front treatment for multiple myeloma

PubMed Central

Dimopoulos, Meletios A.; Dispenzieri, Angela; Catalano, John V.; Belch, Andrew; Cavo, Michele; Pinto, Antonello; Weisel, Katja; Ludwig, Heinz; Bahlis, Nizar J.; Banos, Anne; Tiab, Mourad; Delforge, Michel; Cavenagh, Jamie D.; Geraldes, Catarina; Lee, Je-Jung; Chen, Christine; Oriol, Albert; De La Rubia, Javier; White, Darrell; Binder, Daniel; Lu, Jin; Anderson, Kenneth C.; Moreau, Philippe; Attal, Michel; Perrot, Aurore; Arnulf, Bertrand; Qiu, Lugui; Roussel, Murielle; Boyle, Eileen; Manier, Salomon; Mohty, Mohamad; Avet-Loiseau, Herve; Leleu, Xavier; Ervin-Haynes, Annette; Chen, Guang; Houck, Vanessa; Benboubker, Lotfi; Hulin, Cyrille

2018-01-01

This FIRST trial final analysis examined survival outcomes in patients with transplant-ineligible newly diagnosed multiple myeloma (NDMM) treated with lenalidomide and low-dose dexamethasone until disease progression (Rd continuous), Rd for 72 weeks (18 cycles; Rd18), or melphalan, prednisone, and thalidomide (MPT; 72 weeks). The primary endpoint was progression-free survival (PFS; primary comparison: Rd continuous vs MPT). Overall survival (OS) was a key secondary endpoint (final analysis prespecified ≥60 months’ follow-up). Patients were randomized to Rd continuous (n = 535), Rd18 (n = 541), or MPT (n = 547). At a median follow-up of 67 months, PFS was significantly longer with Rd continuous vs MPT (hazard ratio [HR], 0.69; 95% confidence interval [CI], 0.59-0.79; P < .00001) and was similarly extended vs Rd18. Median OS was 10 months longer with Rd continuous vs MPT (59.1 vs 49.1 months; HR, 0.78; 95% CI, 0.67-0.92; P = .0023), and similar with Rd18 (62.3 months). In patients achieving complete or very good partial responses, Rd continuous had an ≈30-month longer median time to next treatment vs Rd18 (69.5 vs 39.9 months). Over half of all patients who received second-line treatment were given a bortezomib-based therapy. Second-line outcomes were improved in patients receiving bortezomib after Rd continuous and Rd18 vs after MPT. No new safety concerns, including risk for secondary malignancies, were observed. Treatment with Rd continuous significantly improved survival outcomes vs MPT, supporting Rd continuous as a standard of care for patients with transplant-ineligible NDMM. This trial was registered at www.clinicaltrials.gov as #NCT00689936 and EudraCT as 2007-004823-39. PMID:29150421

42 CFR 457.65 - Effective date and duration of State plans and plan amendments.

Code of Federal Regulations, 2011 CFR

2011-10-01

... funding. A State plan amendment that changes the source of the State share of funding can take effect no.... Except as otherwise limited by this section— (1) A State plan or plan amendment takes effect on the day... amendment. (3) A State plan amendment that takes effect prior to submission of the amendment to CMS may...

42 CFR 457.65 - Effective date and duration of State plans and plan amendments.

Code of Federal Regulations, 2014 CFR

2014-10-01

... funding. A State plan amendment that changes the source of the State share of funding can take effect no.... Except as otherwise limited by this section— (1) A State plan or plan amendment takes effect on the day... amendment. (3) A State plan amendment that takes effect prior to submission of the amendment to CMS may...

76 FR 38613 - Initiation of Five-Year (“Sunset”) Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-01

.... Alloy Steel Pipe (3rd Review). A-580-809 731-TA-533 South Korea Circular Welded Non- David Goldberger, (202) 482-4136. Alloy Steel Pipe (3rd Review). A-489-501 731-TA-273 Turkey Welded Carbon Steel David Goldberger, (202) 482-4136. Pipe & Tube (3rd Review). C-489-502 701-TA-253 Turkey Welded Carbon Steel David...

Foundational Skills to Support Reading for Understanding in Kindergarten through 3rd Grade. Educator's Practice Guide. NCEE 2016-4008

ERIC Educational Resources Information Center

Foorman, Barbara; Beyler, Nicholas; Borradaile, Kelley; Coyne, Michael; Denton, Carolyn A.; Dimino, Joseph; Furgeson, Joshua; Hayes, Lynda; Henke, Juliette; Justice, Laura; Keating, Betsy; Lewis, Warnick; Sattar, Samina; Streke, Andrei; Wagner, Richard; Wissel, Sarah

2016-01-01

The goal of this practice guide is to offer educators specific, evidence-based recommendations for teaching foundational reading skills to students in kindergarten through 3rd grade. This guide is a companion to the existing practice guide, "Improving Reading Comprehension in Kindergarten Through 3rd Grade", and as a set, these guides…

Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program

PubMed Central

Hamey, Fiona K.; Errami, Youssef

2017-01-01

Differentiation of lineage-committed cells from multipotent progenitors requires the establishment of accessible chromatin at lineage-specific transcriptional enhancers and promoters, which is mediated by pioneer transcription factors that recruit activating chromatin remodeling complexes. Here we show that the Mbd3/nucleosome remodeling and deacetylation (NuRD) chromatin remodeling complex opposes this transcriptional pioneering during B cell programming of multipotent lymphoid progenitors by restricting chromatin accessibility at B cell enhancers and promoters. Mbd3/NuRD-deficient lymphoid progenitors therefore prematurely activate a B cell transcriptional program and are biased toward overproduction of pro–B cells at the expense of T cell progenitors. The striking reduction in early thymic T cell progenitors results in compensatory hyperproliferation of immature thymocytes and development of T cell lymphoma. Our results reveal that Mbd3/NuRD can regulate multilineage differentiation by constraining the activation of dormant lineage-specific enhancers and promoters. In this way, Mbd3/NuRD protects the multipotency of lymphoid progenitors, preventing B cell–programming transcription factors from prematurely enacting lineage commitment. Mbd3/NuRD therefore controls the fate of lymphoid progenitors, ensuring appropriate production of lineage-committed progeny and suppressing tumor formation. PMID:28899870

Large Sequence Polymorphisms of the Euro-American lineage of Mycobacterium tuberculosis: a phylogenetic reconstruction and evidence for convergent evolution in the DR locus.

PubMed

Rindi, Laura; Lari, Nicoletta; Garzelli, Carlo

2012-10-01

The Euro-American lineage of the Mycobacterium tuberculosis complex consists of 10 sublineages, each defined by a deletion of a large genomic region (RD, region of difference); by spoligotyping, that probes the polymorphism of the Direct Repeat (DR) locus, the Euro-American strains are classified into 5 lineages (T, Haarlem, LAM, S and X) and 34 sublineages, but the relationships between the RD-defined sublineages and the spoligotype groupings are largely unclear. By testing a global sample of 158 Euro-American strains, mutually exclusive deletions of RD115, RD122, RD174, RD182, RD183, RD193, RD219, RD726 or RD761 were found in 122 strains; deletion of RD724, typical of strains from Central Africa, was not found. The RD-defined sublineages, tested for katG463/gyrA95 polymorphism, belonged to Principal Genotypic Group (PGG) 2, with the exception of RD219 sublineage belonging to PGG3; the 36 strains with no deletion were of either PGG2 or 3. Based on these polymorphisms, a phylogenetic reconstruction of the Euro-American lineage, that integrates the previously reported phylogeny, is proposed. Although certain deletions were found to be associated to certain spoligotype lineages (i.e., deletion RD115 to T and LAM, RD174 to LAM, RD182 to Haarlem, RD219 to T), our analysis indicates a general lack of concordance between RD-defined sublineages and spoligotype groupings. Moreover, of the 42 spoligotypes detected among the study strains, sixteen were shared by strains belonging to different RD sublineages. IS6110-RFLP analysis of strains sharing spoligotypes confirmed a poor genetic relatedness between strains of different RD sublineages. These findings provide evidence for the occurrence of a high degree of homoplasy in the DR locus leading to convergent evolution to identical spoligotypes. The incongruence between Large Sequence Polymorphism and spoligotype polymorphism argues against the use of spoligotyping for establishing phylogenetic relationships within the Euro-American lineage. Copyright © 2012 Elsevier B.V. All rights reserved.

10 CFR 1045.4 - Responsibilities.

Code of Federal Regulations, 2013 CFR

2013-01-01

... declassification of RD and FRD in accordance with the Atomic Energy Act; (2) In coordination with the DoD, develop regulations to implement the RD and FRD classification system; (3) Determine whether nuclear-related information is RD; (4) Oversee agency implementation of the RD and FRD classification system to ensure...

10 CFR 1045.4 - Responsibilities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... declassification of RD and FRD in accordance with the Atomic Energy Act; (2) In coordination with the DoD, develop regulations to implement the RD and FRD classification system; (3) Determine whether nuclear-related information is RD; (4) Oversee agency implementation of the RD and FRD classification system to ensure...

10 CFR 1045.4 - Responsibilities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... declassification of RD and FRD in accordance with the Atomic Energy Act; (2) In coordination with the DoD, develop regulations to implement the RD and FRD classification system; (3) Determine whether nuclear-related information is RD; (4) Oversee agency implementation of the RD and FRD classification system to ensure...

10 CFR 1045.4 - Responsibilities.

Code of Federal Regulations, 2012 CFR

2012-01-01

... declassification of RD and FRD in accordance with the Atomic Energy Act; (2) In coordination with the DoD, develop regulations to implement the RD and FRD classification system; (3) Determine whether nuclear-related information is RD; (4) Oversee agency implementation of the RD and FRD classification system to ensure...

10 CFR 1045.4 - Responsibilities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... declassification of RD and FRD in accordance with the Atomic Energy Act; (2) In coordination with the DoD, develop regulations to implement the RD and FRD classification system; (3) Determine whether nuclear-related information is RD; (4) Oversee agency implementation of the RD and FRD classification system to ensure...

Episiotomy: the final cut?

PubMed

Steiner, Naama; Weintraub, Adi Y; Wiznitzer, Arnon; Sergienko, Ruslan; Sheiner, Eyal

2012-12-01

To investigate whether episiotomy prevents 3rd or 4th degree perineal tears in critical conditions such as shoulder dystocia, instrumental deliveries (vacuum or forceps), persistent occiput-posterior position, fetal macrosomia (>4,000 g), and non-reassuring fetal heart rate (NRFHR) patterns. A retrospective study comparing 3rd and 4th degree perineal tears during vaginal deliveries with or without episiotomy, in selected critical conditions was performed. Multiple gestations, preterm deliveries (<37 weeks' gestation) and cesarean deliveries were excluded from the analysis. Stratified analysis (using the Mantel-Haenszel technique) was used to obtain the weighted odds ratio (OR), while controlling for these variables. During the study period, there were 168,077 singleton vaginal deliveries. Of those, 188 (0.1%) had 3rd or 4th degree perineal tears. Vaginal deliveries with episiotomy had statistically significant higher rates of 3rd or 4th degree perineal tears than those without episiotomy (0.2 vs. 0.1%; P<0.001). The association between episiotomy and severe perineal tears remained significant even in the critical conditions. Stratified analysis revealed that the adjusted ORs for 3rd or 4th degree perineal tears in these critical conditions (Macrosomia OR=2.3; instrumental deliveries OR=1.8; NRFHR patterns OR=2.1; occipito-posterior position OR=2.3; and shoulder dystocia OR=2.3) were similar to the crude OR (OR=2.3). Mediolateral episiotomy is an independent risk factor for 3rd or 4th degree perineal tears, even in critical conditions such as shoulder dystocia, instrumental deliveries, occiput-posterior position, fetal macrosomia, and NRFHR. Prophylactic use of episiotomy in these conditions does not seem beneficial if performed to prevent 3rd or 4th degree perineal tears.

30 CFR 950.16 - Required program amendments.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Required program amendments. 950.16 Section 950... shall submit a revision to its permanent program rules at chapter IV, section 3(i) or otherwise propose... rules at chapter IV, section 3(u) or otherwise propose to amend its program to give the State the...

77 FR 30506 - Fisheries of the Caribbean, Gulf of Mexico, South Atlantic; Comprehensive Amendment

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-23

... environment of management measures proposed in its draft Comprehensive Ecosystem-Based Amendment 3 (CE-BA 3). CE-BA 3 would amend the Fishery Management Plan (FMP) for: the Snapper-Grouper Fishery of the South... scope of the issues to be addressed in CE-BA 3 will be accepted until June 22, 2012, at 5 p.m. ADDRESSES...

Accuracy in identifying the elbow rotation axis on simulated fluoroscopic images using a new anatomical landmark.

PubMed

Wiggers, J K; Snijders, R M; Dobbe, J G G; Streekstra, G J; den Hartog, D; Schep, N W L

2017-11-01

External fixation of the elbow requires identification of the elbow rotation axis, but the accuracy of traditional landmarks (capitellum and trochlea) on fluoroscopy is limited. The relative distance (RD) of the humerus may be helpful as additional landmark. The first aim of this study was to determine the optimal RD that corresponds to an on-axis lateral image of the elbow. The second aim was to assess whether the use of the optimal RD improves the surgical accuracy to identify the elbow rotation axis on fluoroscopy. CT scans of elbows from five volunteers were used to simulate fluoroscopy; the actual rotation axis was calculated with CT-based flexion-extension analysis. First, three observers measured the optimal RD on simulated fluoroscopy. The RD is defined as the distance between the dorsal part of the humerus and the projection of the posteromedial cortex of the distal humerus, divided by the anteroposterior diameter of the humerus. Second, eight trauma surgeons assessed the elbow rotation axis on simulated fluoroscopy. In a preteaching session, surgeons used traditional landmarks. The surgeons were then instructed how to use the optimal RD as additional landmark in a postteaching session. The deviation from the actual rotation axis was expressed as rotational and translational error (±SD). Measurement of the RD was robust and easily reproducible; the optimal RD was 45%. The surgeons identified the elbow rotation axis with a mean rotational error decreasing from 7.6° ± 3.4° to 6.7° ± 3.3° after teaching how to use the RD. The mean translational error decreased from 4.2 ± 2.0 to 3.7 ± 2.0 mm after teaching. The humeral RD as additional landmark yielded small but relevant improvements. Although fluoroscopy-based external fixator alignment to the elbow remains prone to error, it is recommended to use the RD as additional landmark.

76 FR 71867 - Addition of Certain Persons to the Entity List; and Implementation of Entity List Annual Review...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-21

.... Microrayan 3rd Apt. 45, block 21, Kabul, Afghanistan, and A2 Ground Floor, City Computer Plaza, Shar-e-Naw... --Ibrahim Walid Microrayan 3rd Apt. 45, Block No. 21, Kabul, Afghanistan. China (1) Xian Semi Electronic Co.... --Farid; and 744.11 of the --Engineer Idris. EAR). Microrayan 3rd Apt. 45, block 21, Kabul, Afghanistan...

PreK-3rd: How Superintendents Lead Change. PreK-3rd Policy Action Brief. No. Five

ERIC Educational Resources Information Center

Marietta, Geoff

2010-01-01

Leading change to create an integrated PreK-3rd education and connect early learning programs with the K-12 system is not easy. Superintendents require courage to take the first step, persistence and political skills to encourage organizational and community engagement, and a relentless focus on results to measure progress and build momentum. As a…

Effects of Intensive Fluency Instruction on the Reading Proficiency of Third-Grade Struggling Readers

ERIC Educational Resources Information Center

Rasinski, Timothy; Paige, David; Rains, Cameron; Stewart, Fran; Julovich, Brenda; Prenkert, Deb; Rupley, William H.; Nichols, William Dee

2017-01-01

The present study examined the impact of an intensive reading fluency intervention on the overall reading performance of 37 struggling readers in 3rd grade. Students' 3rd-grade classroom teachers and/or their performance on a state-mandated reading achievement test given toward the end of the 3rd-grade school year identified them for the study.…

77 FR 40479 - Airworthiness Directives; Rolls-Royce Corporation Turboshaft Engines

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-10

... inspection (FPI) on certain 3rd and 4th stage turbine wheels for cracks in the turbine blades. We are issuing this AD to prevent failure of 3rd or 4th stage turbine wheel blades which could cause engine failure... certain 3rd and 4th stage turbine wheels for cracks in the turbine blades. Comments We gave the public the...

Genotype-phenotype correlation and functional studies in patients with cystic fibrosis bearing CFTR complex alleles.

PubMed

Terlizzi, Vito; Castaldo, Giuseppe; Salvatore, Donatello; Lucarelli, Marco; Raia, Valeria; Angioni, Adriano; Carnovale, Vincenzo; Cirilli, Natalia; Casciaro, Rosaria; Colombo, Carla; Di Lullo, Antonella Miriam; Elce, Ausilia; Iacotucci, Paola; Comegna, Marika; Scorza, Manuela; Lucidi, Vincenzina; Perfetti, Anna; Cimino, Roberta; Quattrucci, Serena; Seia, Manuela; Sofia, Valentina Maria; Zarrilli, Federica; Amato, Felice

2017-04-01

The effect of complex alleles in cystic fibrosis (CF) is poorly defined for the lack of functional studies. To describe the genotype-phenotype correlation and the results of either in vitro and ex vivo studies performed on nasal epithelial cells (NEC) in a cohort of patients with CF carrying cystic fibrosis transmembrane conductance regulator ( CFTR ) complex alleles. We studied 70 homozygous, compound heterozygous or heterozygous for CFTR mutations: p.[Arg74Trp;Val201Met;Asp1270Asn], n=8; p.[Ile148Thr;Ile1023_Val1024del], n=5; p.[Arg117Leu;Leu997Phe], n=6; c.[1210-34TG[12];1210-12T[5];2930C>T], n=3; p.[Arg74Trp;Asp1270Asn], n=4; p.Asp1270Asn, n=2; p.Ile148Thr, n=6; p.Leu997Phe, n=36. In 39 patients, we analysed the CFTR gating activity on NEC in comparison with patients with CF (n=8) and carriers (n=4). Finally, we analysed in vitro the p.[Arg74Trp;Val201Met;Asp1270Asn] complex allele. The p.[Ile148Thr;Ile1023_Val1024del] caused severe CF in five compound heterozygous with a class I-II mutation. Their CFTR activity on NEC was comparable with patients with two class I-II mutations (mean 7.3% vs 6.9%). The p.[Arg74Trp;Asp1270Asn] and the p.Asp1270Asn have scarce functional effects, while p.[Arg74Trp;Val201Met;Asp1270Asn] caused mild CF in four of five subjects carrying a class I-II mutation in trans , or CFTR-related disorders (CFTR-RD) in three having in trans a class IV-V mutation. The p.[Arg74Trp;Val201Met;Asp1270Asn] causes significantly (p<0.001) higher CFTR activity compared with compound heterozygous for class I-II mutations. Furthermore, five of six compounds heterozygous with the p.[Arg117Leu;Leu997Phe] had mild CF, whereas the p.Leu997Phe, in trans with a class I-II CFTR mutation, caused CFTR-RD or a healthy status (CFTR activity: 21.3-36.9%). Finally, compounds heterozygous for the c.[1210-34TG[12];1210-12T[5];2930C>T] and a class I-II mutation had mild CF or CFTR-RD (gating activity: 18.5-19.0%). The effect of complex alleles partially depends on the mutation in trans . Although larger studies are necessary, the CFTR activity on NEC is a rapid contributory tool to classify patients with CFTR dysfunction. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

76 FR 36511 - Fisheries of the Northeastern United States; Atlantic Deep-Sea Red Crab; Amendment 3

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-22

...-BA22 Fisheries of the Northeastern United States; Atlantic Deep-Sea Red Crab; Amendment 3 AGENCY... the Atlantic Deep-Sea Red Crab Fishery Management Plan (FMP) (Amendment 3), incorporating a draft... current trap limit regulations state that red crab may not be harvested from gear other than a marked red...

Is an alcohol ignition interlock programme a useful tool for changing the alcohol and driving habits of drink-drivers?

PubMed

Bjerre, Bo; Thorsson, Ulf

2008-01-01

This study evaluates whether the completion of an alcohol ignition interlock programme (AIIP) results in lasting changes of the behaviour of drink drivers and whether such a programme is more effective than a conventional licence revocation followed by an approved doctor's assessment. In Sweden, DWI offenders can voluntarily select a 2-year AIIP in lieu of a 12-month licence revocation. The AIIP includes regular medical checkups designed to alter alcohol use habits. The study has a quasi-experimental design. Two groups of controls were used for comparisons. One with revoked licences, but with no comparable opportunity to participate in an AIIP and another with DWI offenders who had abstained from participating in the AIIP. Significantly more persons were relicensed in the AIIP group 2 and 3 years after the DWI offence. According to the AUDIT scores participants in the AIIP had lower rates of harmful alcohol consumption than compared controls 1 and 3 years after the DWI offence. In the post-treatment period the rate of DWI recidivism was about 60% and the rate of police-reported traffic accidents about 80% lower than during the 5-year period prior to the offence. Among controls being relicensed a similar reduction in traffic accidents, but not in DWI recidivism, was observed. In the post-treatment period sick leave, but not hospital-care utilisation, differed significantly between the groups. The completion of an AIIP has favourable effects compared to conventional licence revocation and would appear to be a useful tool for attaining lasting changes in the alcohol and driving habits of DWI offenders.

17 CFR 275.204-1 - Amendments to Form ADV.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Amendments to Form ADV. 275... (CONTINUED) RULES AND REGULATIONS, INVESTMENT ADVISERS ACT OF 1940 § 275.204-1 Amendments to Form ADV. (a) When amendment is required. You must amend your Form ADV (17 CFR 279.1): (1) At least annually, within...

PreK-3rd: Next Steps for State Longitudinal Data Systems. PreK-3rd Policy Action Brief. No. Eight

ERIC Educational Resources Information Center

Hernandez, Donald J.

2012-01-01

The growing movement to strengthen PreK-3rd education as an essential foundation for student success, along with the rapid expansion in public funding for PreK, has created an urgent need to measure children's educational progress, in a continuous fashion, from the beginning of PreK through Grade Three. Currently, some state governments are…

Do 2nd and 3rd Grade Teachers' Linguistic Knowledge and Instructional Practices Predict Spelling Gains in Weaker Spellers?

ERIC Educational Resources Information Center

Puliatte, Alison; Ehri, Linnea C.

2018-01-01

The relationship between 2nd and 3rd grade teachers' linguistic knowledge and spelling instructional practices and their students' spelling gains from fall to spring was examined. Second grade (N = 16) and 3rd grade (N = 16) teachers were administered an instructional practices survey and a linguistic knowledge test. Total scores on the two…

The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation.

PubMed

Choi, Won-Il; Jeon, Bu-Nam; Yoon, Jae-Hyeon; Koh, Dong-In; Kim, Myung-Hwa; Yu, Mi-Young; Lee, Kyung-Mi; Kim, Youngsoo; Kim, Kyunggon; Hur, Sujin Susanne; Lee, Choong-Eun; Kim, Kyung-Sup; Hur, Man-Wook

2013-07-01

The tumour-suppressor gene CDKN1A (encoding p21Waf/Cip1) is thought to be epigenetically repressed in cancer cells. FBI-1 (ZBTB7A) is a proto-oncogenic transcription factor repressing the alternative reading frame and p21WAF/CDKN1A genes of the p53 pathway. FBI-1 interacts directly with MBD3 (methyl-CpG-binding domain protein 3) in the nucleus. We demonstrated that FBI-1 binds both non-methylated and methylated DNA and that MBD3 is recruited to the CDKN1A promoter through its interaction with FBI-1, where it enhances transcriptional repression by FBI-1. FBI-1 also interacts with the co-repressors nuclear receptor corepressor (NCoR), silencing mediator for retinoid and thyroid receptors (SMRT) and BCL-6 corepressor (BCoR) to repress transcription. MBD3 regulates a molecular interaction between the co-repressor and FBI-1. MBD3 decreases the interaction between FBI-1 and NCoR/SMRT but increases the interaction between FBI-1 and BCoR. Because MBD3 is a subunit of the Mi-2 autoantigen (Mi-2)/nucleosome remodelling and histone deacetylase (NuRD)-HDAC complex, FBI-1 recruits the Mi-2/NuRD-HDAC complex via MBD3. BCoR interacts with the Mi-2/NuRD-HDAC complex, DNMTs and HP1. MBD3 and BCoR play a significant role in the recruitment of the Mi-2/NuRD-HDAC complex- and the NuRD complex-associated proteins, DNMTs and HP. By recruiting DNMTs and HP1, Mi-2/NuRD-HDAC complex appears to play key roles in epigenetic repression of CDKN1A by DNA methylation.

A tale of two cities: the effect of extended drinking hours in licensed establishments on impaired driving and assault charges.

PubMed

Vingilis, Evelyn; Mcleod, A Ian; Mann, Robert E; Seeley, Jane

2008-12-01

On May 1, 1996, Ontario, Canada, amended the Liquor Licence Act to extend the hours of alcohol sales and service in licensed establishments from 1 to 2 a.m. The purpose of this study was to examine the effect of extended drinking hours on two cities in southwestern Ontario, Canada, one of which (London) would be affected by the alcohol control policy of extended drinking hours and the second city (Windsor) would be affected by two alcohol policies, extended drinking hours, and cross-border legal drinking age differences between Ontario and Michigan. Specifically, this study tested whether there were differences in impaired driving and assault charges in London and Windsor, Ontario, concomitant with the extended drinking hour amendment. A quasi-experimental design using interrupted time series was used to assess changes. The analyzed data sets were monthly police impaired driving and assault charges data for Ontario, for the 11-12 p.m., 12-1 a.m., 1-2 a.m., 2-3 a.m. and 3-4 a.m. time windows, for 4 years pre- and 3 years post-policy change. Overall, London and Windsor exhibited significant overall reductions in impaired driving charges and no changes for assault charges aggregated over the 11 p.m.-4 a.m. time period after the drinking hours were extended. Within the different time windows, London showed significant decreases for the 1-2 a.m. Sunday-Wednesday and Thursday-Sunday time periods and a significant increase for the Sunday-Wednesday 3-4 a.m. time period, while Windsor demonstrated significant decreases in impaired driving charges for 1-2 a.m. Sunday-Wednesday and Thursday-Saturday time periods and significant increases for Sunday-Wednesday 2-3 and 3-4 a.m. and for Thursday-Saturday 2-3 a.m. For assault charges, no overall pre-post differences were found for the aggregated 11 p.m.-4 a.m. time period for either city. When the data were disaggregated by hour, a significant decrease was found in London for Thursday-Saturday 1-2 a.m. and significant increases for Sunday-Wednesday 2-3 a.m. and Thursday-Saturday 3-4 a.m. time periods, while no significant decreases were found in Windsor during the 1-2 a.m. time periods and one significant increase occurred during the Thursday-Saturday 2-3 a.m. time period. These findings, based on police data, suggest no overall effect on charges aggregated over the 11 p.m. to 4 a.m. time window, although some differences were observed for the different hours after 2 a.m., with a possible effect of the one hour extension of drinking in licensed establishments.

The social licence for research: why care.data ran into trouble

PubMed Central

Carter, Pam; Laurie, Graeme T; Dixon-Woods, Mary

2015-01-01

In this article we draw on the concept of a social licence to explain public concern at the introduction of care.data, a recent English initiative designed to extract data from primary care medical records for commissioning and other purposes, including research. The concept of a social licence describes how the expectations of society regarding some activities may go beyond compliance with the requirements of formal regulation; those who do not fulfil the conditions for the social licence (even if formally compliant) may experience ongoing challenge and contestation. Previous work suggests that people's cooperation with specific research studies depends on their perceptions that their participation is voluntary and is governed by values of reciprocity, non-exploitation and service of the public good. When these conditions are not seen to obtain, threats to the social licence for research may emerge. We propose that care.data failed to adequately secure a social licence because of: (i) defects in the warrants of trust provided for care.data, (ii) the implied rupture in the traditional role, expectations and duties of general practitioners, and (iii) uncertainty about the status of care.data as a public good. The concept of a social licence may be useful in explaining the specifics of care.data, and also in reinforcing the more general lesson for policy-makers that legal authority does not necessarily command social legitimacy. PMID:25617016

Variable phenotypic expressivity in inbred retinal degeneration mouse lines: A comparative study of C3H/HeOu and FVB/N rd1 mice.

PubMed

van Wyk, Michiel; Schneider, Sabine; Kleinlogel, Sonja

2015-01-01

Recent advances in optogenetics and gene therapy have led to promising new treatment strategies for blindness caused by retinal photoreceptor loss. Preclinical studies often rely on the retinal degeneration 1 (rd1 or Pde6b(rd1)) retinitis pigmentosa (RP) mouse model. The rd1 founder mutation is present in more than 100 actively used mouse lines. Since secondary genetic traits are well-known to modify the phenotypic progression of photoreceptor degeneration in animal models and human patients with RP, negligence of the genetic background in the rd1 mouse model is unwarranted. Moreover, the success of various potential therapies, including optogenetic gene therapy and prosthetic implants, depends on the progress of retinal degeneration, which might differ between rd1 mice. To examine the prospect of phenotypic expressivity in the rd1 mouse model, we compared the progress of retinal degeneration in two common rd1 lines, C3H/HeOu and FVB/N. We followed retinal degeneration over 24 weeks in FVB/N, C3H/HeOu, and congenic Pde6b(+) seeing mouse lines, using a range of experimental techniques including extracellular recordings from retinal ganglion cells, PCR quantification of cone opsin and Pde6b transcripts, in vivo flash electroretinogram (ERG), and behavioral optokinetic reflex (OKR) recordings. We demonstrated a substantial difference in the speed of retinal degeneration and accompanying loss of visual function between the two rd1 lines. Photoreceptor degeneration and loss of vision were faster with an earlier onset in the FVB/N mice compared to C3H/HeOu mice, whereas the performance of the Pde6b(+) mice did not differ significantly in any of the tests. By postnatal week 4, the FVB/N mice expressed significantly less cone opsin and Pde6b mRNA and had neither ERG nor OKR responses. At 12 weeks of age, the retinal ganglion cells of the FVB/N mice had lost all light responses. In contrast, 4-week-old C3H/HeOu mice still had ERG and OKR responses, and we still recorded light responses from C3H/HeOu retinal ganglion cells until the age of 24 weeks. These results show that genetic background plays an important role in the rd1 mouse pathology. Analogous to human RP, the mouse genetic background strongly influences the rd1 phenotype. Thus, different rd1 mouse lines may follow different timelines of retinal degeneration, making exact knowledge of genetic background imperative in all studies that use rd1 models.

PET imaging predicts future body weight and cocaine preference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Michaelides M.; Wang G.; Michaelides M.

Deficits in dopamine D2/D3 receptor (D2R/D3R) binding availability using PET imaging have been reported in obese humans and rodents. Similar deficits have been reported in cocaine-addicts and cocaine-exposed primates. We found that D2R/D3R binding availability negatively correlated with measures of body weight at the time of scan (ventral striatum), at 1 (ventral striatum) and 2 months (dorsal and ventral striatum) post scan in rats. Cocaine preference was negatively correlated with D2R/D3R binding availability 2 months (ventral striatum) post scan. Our findings suggest that inherent deficits in striatal D2R/D3R signaling are related to obesity and drug addiction susceptibility and that ventralmore » and dorsal striatum serve dissociable roles in maintaining weight gain and cocaine preference. Measuring D2R/D3R binding availability provides a way for assessing susceptibility to weight gain and cocaine abuse in rodents and given the translational nature of PET imaging, potentially primates and humans.« less

76 FR 58821 - New Hampshire; Amendment No. 3 to Notice of a Major Disaster Declaration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-22

.... FEMA-4026-DR] [Docket ID FEMA-2011-0001] New Hampshire; Amendment No. 3 to Notice of a Major Disaster... notice of a major disaster declaration for the State of New Hampshire (FEMA-4026-DR), dated September 3... declaration for the State of New Hampshire is hereby amended to include the following areas among those areas...

Cargo Movement Operations System (CMOS). Updated Software Requirements Specifications, Increment 2, (Communications CSCI)

DTIC Science & Technology

1990-11-14

NO [ ] COMMENT DISPOSITION: COMMENT STATUS: OPEN [ ] CLOSED [ ] ORIGINATOR CONTROL NUMBER: SRS2-0002 PROGRAM OFFICE CONTROL NUMBER: DATA ITEM...e. (1st and 3rd sentence), 3.2.7.21, and 3.2.8 b. CMOS PMO ACCEPTS COMMENT: YES [ ] NO [ ] ERCI ACCEPTS COMMENT: YES [ ] NO [ COMMENT DISPOSITION...3rd 3.2.7.6 4th 3.2.7.22 4th 3.2.7.7 4th 3.2.8 d. 2nd & 3rd 3.2.7.9 4th 3.2.8 e. 2nd CMOS PMO ACCEPTS COMMENT: YES [ ] NO [ ] ERCI ACCEPTS COMMENT: YES [ ] NO [ ] COMMENT DISPOSITION: COMMENT STATUS: OPEN [

15 CFR 921.82 - Amendments to financial assistance awards.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Amendments to financial assistance... COASTAL RESOURCE MANAGEMENT NATIONAL ESTUARINE RESEARCH RESERVE SYSTEM REGULATIONS General Financial Assistance Provisions § 921.82 Amendments to financial assistance awards. Actions requiring an amendment to...

31 CFR 548.402 - Effect of amendment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Effect of amendment. 548.402 Section 548.402 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... Effect of amendment. Unless otherwise specifically provided, any amendment, modification, or revocation...

76 FR 30375 - Mississippi; Amendment No. 3 to Notice of an Emergency Declaration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-25

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Internal Agency Docket No. FEMA-3320-EM; Docket ID FEMA-2011-0001] Mississippi; Amendment No. 3 to Notice of an Emergency Declaration AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: This notice amends the...

76 FR 56773 - Vermont; Amendment No. 3 to Notice of a Major Disaster Declaration.

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-14

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Internal Agency Docket No. FEMA-4022-DR; Docket ID FEMA-2011-0001] Vermont; Amendment No. 3 to Notice of a Major Disaster Declaration. AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: This notice amends the...

76 FR 65740 - Pennsylvania; Amendment No. 3 to Notice of a Major Disaster Declaration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-24

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Internal Agency Docket No. FEMA-4030-DR; Docket ID FEMA-2011-0001] Pennsylvania; Amendment No. 3 to Notice of a Major Disaster Declaration AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: This notice amends the...

76 FR 60077 - Maryland; Amendment No. 3 to Notice of an Emergency Declaration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-28

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Internal Agency Docket No. FEMA-3335-EM; Docket ID FEMA-2011-0001] Maryland; Amendment No. 3 to Notice of an Emergency Declaration AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: This notice amends the notice...

75 FR 32235 - Exchange Visitor Program-Secondary School Students

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-07

... amendments to the secondary school student regulatory provisions published in the Federal Register on May 3, 2010 (see 75 FR 23196). As stated in that Notice, the Department proposes to amend existing regulations... discussion on the proposed amendments to these regulations. The proposed rule, published May 3, 2010...

How Should Municipal Police Agencies Participate in America’s Homeland Security Strategy?

DTIC Science & Technology

2008-12-01

NonProfit Organizations: A Guide to Strengthening and Sustaining Organizational Achievement, 3rd ed. (San Francisco, CA: Jossey- Bass , 2004). 43 Ibid 36...Planning for Public and NonProfit Organizations: A Guide to Strengthening and Sustaining Organizational Achievement, 3rd ed. (San Francisco, CA: Jossey- Bass ...Public and NonProfit Organizations: A Guide to Strengthening and Sustaining Organizational Achievement, 3rd ed. (San Francisco, CA: Jossey- Bass , 2004

High Expression of Galectin-3 in Patients with IgG4-Related Disease: A Proteomic Approach.

PubMed

Salah, Adeeb; Yoshifuji, Hajime; Ito, Shinji; Kitagori, Koji; Kiso, Kaori; Yamada, Norishige; Nakajima, Toshiki; Haga, Hironori; Tsuruyama, Tatsuaki; Miyagawa-Hayashino, Aya

2017-01-01

Immunoglobulin G4-related disease (IgG4-RD) is a multiorgan condition manifesting itself in different forms. This study aimed to investigate protein expression profiles and to find the possible biomarker for IgG4-RD by liquid chromatography mass spectrometry (LC-MS) using tissue sections in IgG4-RD patients. Protein expression profiles in five IgG4-related pancreatitis and three normal pancreatic samples were compared using LC-MS and were validated by quantitative real-time PCR (qRT-PCR), immunoblotting, and immunohistochemistry. ELISA was employed in the serum of 20 patients with systemic IgG4-RD before and during steroid treatment. LC-MS indicated that the levels of 17 proteins were significantly higher and 12 others were significantly lower in IgG4-related pancreatitis patients compared to controls. Among these proteins, galectin-3 levels were 13-fold higher in IgG4-related pancreatitis ( P < 0.01). These results were confirmed by immunoblotting and qRT-PCR. The average number of galectin-3 + cells in various organs of IgG4-RD patients, including salivary glands, lungs, and lymph nodes, was higher than in controls. Galectin-3 was detectable in macrophages, dendritic cells, and stromal myofibroblast-like cells, but not in lymphocytes by immunofluorescence staining. Serum galectin-3 levels were higher in patients with IgG4-RD compared with healthy donors and remained high during steroid therapy. Galectin-3 was overexpressed in IgG4-RD and the levels were indirectly related to clinical activity.

High Expression of Galectin-3 in Patients with IgG4-Related Disease: A Proteomic Approach

PubMed Central

Salah, Adeeb; Yoshifuji, Hajime; Ito, Shinji; Kitagori, Koji; Kiso, Kaori; Yamada, Norishige; Nakajima, Toshiki; Haga, Hironori; Tsuruyama, Tatsuaki

2017-01-01

Objectives Immunoglobulin G4-related disease (IgG4-RD) is a multiorgan condition manifesting itself in different forms. This study aimed to investigate protein expression profiles and to find the possible biomarker for IgG4-RD by liquid chromatography mass spectrometry (LC-MS) using tissue sections in IgG4-RD patients. Methods Protein expression profiles in five IgG4-related pancreatitis and three normal pancreatic samples were compared using LC-MS and were validated by quantitative real-time PCR (qRT-PCR), immunoblotting, and immunohistochemistry. ELISA was employed in the serum of 20 patients with systemic IgG4-RD before and during steroid treatment. Results LC-MS indicated that the levels of 17 proteins were significantly higher and 12 others were significantly lower in IgG4-related pancreatitis patients compared to controls. Among these proteins, galectin-3 levels were 13-fold higher in IgG4-related pancreatitis (P < 0.01). These results were confirmed by immunoblotting and qRT-PCR. The average number of galectin-3 + cells in various organs of IgG4-RD patients, including salivary glands, lungs, and lymph nodes, was higher than in controls. Galectin-3 was detectable in macrophages, dendritic cells, and stromal myofibroblast-like cells, but not in lymphocytes by immunofluorescence staining. Serum galectin-3 levels were higher in patients with IgG4-RD compared with healthy donors and remained high during steroid therapy. Conclusion Galectin-3 was overexpressed in IgG4-RD and the levels were indirectly related to clinical activity. PMID:28593065

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

PubMed Central

Zhang, Yi; Ng, Huck-Hui; Erdjument-Bromage, Hediye; Tempst, Paul; Bird, Adrian; Reinberg, Danny

1999-01-01

ATP-dependent nucleosome remodeling and core histone acetylation and deacetylation represent mechanisms to alter nucleosome structure. NuRD is a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. The histone deacetylases HDAC1 and HDAC2 and the histone binding proteins RbAp48 and RbAp46 form a core complex shared between NuRD and Sin3-histone deacetylase complexes. The histone deacetylase activity of the core complex is severely compromised. A novel polypeptide highly related to the metastasis-associated protein 1, MTA2, and the methyl-CpG-binding domain-containing protein, MBD3, were found to be subunits of the NuRD complex. MTA2 modulates the enzymatic activity of the histone deacetylase core complex. MBD3 mediates the association of MTA2 with the core histone deacetylase complex. MBD3 does not directly bind methylated DNA but is highly related to MBD2, a polypeptide that binds to methylated DNA and has been reported to possess demethylase activity. MBD2 interacts with the NuRD complex and directs the complex to methylated DNA. NuRD may provide a means of gene silencing by DNA methylation. PMID:10444591

The Rise and Decline of U.S. Private Sector Investments in Energy R&D since the Arab Oil Embargo of 1973

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dooley, James J.

2010-11-01

This paper presents two distinct datasets that describe investments in energy research and development (R&D) by the US private sector since the mid1970s, which is when the US government began to systematically collect these data. The first dataset is based upon a broad survey of more than 20,000 firms’ industrial R&D activities. This broad survey of US industry is coordinated by the US National Science Foundation. The second dataset discussed here is a much narrower accounting of the energy R&D activities of the approximately two dozen largest US oil and gas companies conducted by the US Department of Energy’s Energymore » Information Agency. Even given the large disparity in the breadth and scope of these two surveys of the private sector’s support for energy R&D, both datasets tell the same story in terms of the broad outlines of the private sector’s investments in energy R&D since the mid 1970s. The broad outlines of the US private sector’s support for energy R&D since the mid 1970s is: (1) In the immediate aftermath of the Arab Oil Embargo of 1973, there is a large surge in US private sector investments in energy R&D that peaked in the period between 1980 and 1982 at approximately $3.7 billion to $6.7 billion per year (in inflation adjusted 2010 US dollars) depending upon which survey is used (2) Private sector investments in energy R&D declined from this peak until bottoming out at approximately $1.8 billion to $1 billion per year in 1999; (3) US private sector support for energy R&D has recovered somewhat over the past decade and stands at $2.2 billion to $3.4 billion. Both data sets indicate that the US private sector’s support for energy R&D has been and remains dominated by fossil energy R&D and in particular R&D related to the needs of the oil and gas industry.« less

31 CFR 598.402 - Effect of amendment.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Effect of amendment. 598.402 Section 598.402 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... Interpretations § 598.402 Effect of amendment. Unless otherwise specifically provided, any amendment, modification...

31 CFR 598.402 - Effect of amendment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Effect of amendment. 598.402 Section 598.402 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... Interpretations § 598.402 Effect of amendment. Unless otherwise specifically provided, any amendment, modification...

31 CFR 598.402 - Effect of amendment.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Effect of amendment. 598.402 Section 598.402 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... Interpretations § 598.402 Effect of amendment. Unless otherwise specifically provided, any amendment, modification...

31 CFR 598.402 - Effect of amendment.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Effect of amendment. 598.402 Section 598.402 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... Interpretations § 598.402 Effect of amendment. Unless otherwise specifically provided, any amendment, modification...

31 CFR 598.402 - Effect of amendment.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Effect of amendment. 598.402 Section 598.402 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... Interpretations § 598.402 Effect of amendment. Unless otherwise specifically provided, any amendment, modification...

Wireless Technologies in Support of ISS Experimentation and Operations

NASA Technical Reports Server (NTRS)

Wagner, Raymond; Fink, Patrick

2012-01-01

Presentation reviews: (1) Wireless Communications (a) Internal (b) External (2) RFID (Radio Frequency Identification) (a) Existing and R&D (3) Wireless Sensor Networks (a) Existing and R&D (4) Ultra-Wide Band (UWB) (a) R&D

Are patients referred to rehabilitation diagnosed accurately?

PubMed

Tederko, Piotr; Krasuski, Marek; Nyka, Izabella; Mycielski, Jerzy; Tarnacka, Beata

2017-07-17

An accurate diagnosis of the leading health condition and comorbidities is a prerequisite for safe and effective rehabilitation. The problem of diagnostic errors in physical and rehabilitation medicine (PRM) has not been addressed sufficiently. The responsibility of a referring physician is to determine indications and contraindications for rehabilitation. To assess the rate of and risk factors for inaccurate referral diagnoses (RD) in patients referred to a rehabilitation facility. We hypothesized that inaccurate RD would be more common in patients 1) referred by non-PRM physicians; 2) waiting longer for the admission; 3) older patients. Retrospective observational study. 1000 randomly selected patients admitted between 2012 and 2016 to a day- rehabilitation center (DRC). University DRC specialized in musculoskeletal diseases. On admission all cases underwent clinical verification of RD. Inappropriateness regarding primary diagnoses and comorbidities were noted. Influence of several factors affecting probability of inaccurate RD was analyzed with multiple binary regression model applied to 6 categories of diseases. The rate of inaccurate RD was 25.2%. Higher frequency of inaccurate RD was noted among patients referred by non-PRM specialists (30.3% vs 17.3% in cases referred by PRM specialists). Application of logit regression showed highly significant influence of the specialty of a referring physician on the odds of inaccurate RD (joint Wald test ch2(6)=38.98, p- value=0.000), controlling for the influence of other variables. This may reflect a suboptimal knowledge of the rehabilitation process and a tendency to neglect of comorbidities by non-PRM specialists. The rate of inaccurate RD did not correlate with time between referral and admission (joint Wald test of all odds ratios equal to 1, chi2(6)=5.62, p-value=0.467), however, mean and median waiting times were relatively short (35.7 and 25 days respectively).A high risk of overlooked multimorbidity was revealed in elderly patients (all odds ratios for variable age significantly higher than 1). Hypotheses 1 and 3 were confirmed. Over 25% of patients referred to DRC had inaccurate RD. Risk factors for inaccurate RD include referral by a non-PRM specialist and elderly age. Verification of RD should be routinely introduced to PRM practice.

Plantar pressure distribution of ostrich during locomotion on loose sand and solid ground

PubMed Central

Han, Dianlei; Ma, Songsong; Luo, Gang; Ji, Qiaoli; Xue, Shuliang; Yang, Mingming; Li, Jianqiao

2017-01-01

Background The ostrich is a cursorial bird with extraordinary speed and endurance, especially in the desert, and thus is an ideal large-scale animal model for mechanic study of locomotion on granular substrate. Methods The plantar pressure distributions of ostriches walking/running on loose sand/solid ground were recorded using a dynamic pressure plate. Results The center of pressure (COP) on loose sand mostly originated from the middle of the 3rd toe, which differed from the J-shaped COP trajectory on solid ground. At mid-stance, a high-pressure region was observed in the middle of the 3rd toe on loose sand, but three high-pressure regions were found on solid ground. The gait mode significantly affected the peak pressures of the 3rd and 4th toes (p = 1.5 × 10−6 and 2.39 × 10−8, respectively), but not that of the claw (p = 0.041). The effects of substrate were similar to those of the gait mode. Discussion Ground reaction force trials of each functional part showed the 3rd toe bore more body loads and the 4th toe undertook less loads. The pressure distributions suggest balance maintenance on loose sand was provided by the 3rd and 4th toes and the angle between their length axes. On loose sand, the middle of the 3rd toe was the first to touch the sand with a smaller attack angle to maximize the ground reaction force, but on solid ground, the lateral part was the first to touch the ground to minimize the transient loading. At push-off, the ostrich used solidification properties of granular sand under the compression of the 3rd toe to generate sufficient traction. PMID:28761792

The Power of PreK-3rd: How a Small Foundation Helped Push Washington State to the Forefront of the PreK-3rd Movement. FCD Case Study

ERIC Educational Resources Information Center

Nyhan, Paul

2011-01-01

The New School Foundation was not born from a commission, legislative mandate, research project, think tank, or even the mind of a leading education scholar. One of Washington state's pioneering PreK-3rd initiatives began as the brainchild of a wealthy Seattle businessman, Stuart Sloan, 20 years ago. The New School Foundation and its ideas were…

Sickness absence and disability pension following breast cancer - A population-based matched cohort study.

PubMed

Lundh, Marie Høyer; Lampic, Claudia; Nordin, Karin; Ahlgren, Johan; Bergkvist, Leif; Lambe, Mats; Berglund, Anders; Johansson, Birgitta

2014-12-01

To compare sickness absence and disability pension in a population-based cohort of women with breast cancer (n = 463) from 1 year pre-diagnosis until 3 years post-diagnosis with a matched control group (n = 2310), and to investigate predictors of sickness absence during the 2nd and 3rd year post-diagnosis. Following breast cancer, the proportion of disease-free women with sickness absence decreased post-diagnosis (1st-3rd year; 78%-31%-19%), but did not reach the pre-diagnostic level (14%; P < 0.05). Post-diagnosis, patients were more likely than controls to be sickness absent (1st-3rd year; P < 0.001). No between-group differences were observed for disability pension post-diagnosis (P > 0.05). Among patients, chemotherapy, baseline fatigue and pre-diagnosis sick days predicted sickness absence during the 2nd, 3rd, and 2nd and 3rd year post-diagnosis, respectively (P < 0.05). Breast cancer is associated with increased sickness absence 3 years post-diagnosis. In a clinical setting, prevention and treatment of side effects are important in reducing long-term consequences. Copyright © 2014 Elsevier Ltd. All rights reserved.

Characteristics of Internal Medicine Physicians Disciplined by Professional Colleges in Canada.

PubMed

Liu, Jessica J; Alam, Asim Q; Goldberg, Hanna R; Matelski, John Justin; Bell, Chaim M

2015-07-01

Physician misconduct is of serious concern to patient safety and quality of care. Currently, there are limited data on disciplinary proceedings involving internal medicine (IM) physicians.The aim of this study was to investigate the number and nature of disciplinary cases among IM physicians compared with those of other disciplined physicians.Our retrospective study reviewed information from all provincial Colleges of Physicians and Surgeons (CPS) and compiled a database of all disciplined physicians from 2000 to 2013 in Canada. Disciplinary rate differences (RDs) were calculated for IM physicians and compared with other physicians.From 2000 to 2013, overall disciplinary rates were low (9.6 cases per 10,000 physician years). There were 899 disciplinary cases, 49 of which involved 45 different IM physicians. IM physicians comprised 10.8% of all disciplined physicians and were disciplined at a lower rate than non-IM physicians, incurring 5.18 fewer cases per 10,000 physician years than other physicians (95% confidence interval [CI] 3.62-6.73; P < 0.001). They were significantly less likely to be disciplined for: unprofessional conduct (RD 1.16; CI 0.45-1.87; P = 0.001); unlicensed activity (RD 0.78; CI 0.37-1.19; P < 0.001); standard of care issues (RD 1.37; CI 0.49-2.26; P = 0.002); sexual misconduct (RD 1.65; CI 0.90-2.40; P < 0.001); miscellaneous (RD 0.80; CI 0.11-1.50; P = 0.020); mental illness (RD 0.06; CI 0.01-0.12; P = 0.025); inappropriate prescribing (RD 0.74; CI 0.15-1.33; P = 0.010); and criminal conviction (RD 0.33; CI 0.00-0.65; P = 0.048). No significant differences were found with respect to unclear violations, fraudulent behavior/prevarication, or offenses involving drugs/alcohol (all RDs less than 0.32). IM physicians were also less likely to incur the following penalties: voluntary license surrender (RD 0.53; CI 0.37-0.69; P < 0.001); suspension (RD 2.39; CI 1.26-3.51; P < 0.001); retraining/assessment (RD 1.58; CI 0.77-2.39; P < 0.001); restriction (RD 1.60; CI 0.74-2.46; P < 0.001); other (RD 0.52; CI 0.07-0.97; P = 0.030); formal reprimand (RD 2.78; CI 1.77-3.79; P < 0.001); or fine (RD 3.28; CI 1.89-4.67; P < 0.001). No significant differences were found with respect to revocation or mandated counseling/rehabilitation (all RDs less than 0.46).Generally, disciplinary rates among physicians were low. Compared with other physicians, IM physicians have significantly lower disciplinary rates overall and are less likely to incur the majority of disciplinary offenses and penalties.

32 CFR 505.6 - Amendment of records.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 3 2010-07-01 2010-07-01 true Amendment of records. 505.6 Section 505.6 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS ARMY PRIVACY ACT PROGRAM § 505.6 Amendment of records. (a) Amended records. (1...

12 CFR 269.12 - Amendment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Amendment. 269.12 Section 269.12 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM POLICY ON LABOR RELATIONS FOR THE FEDERAL RESERVE BANKS § 269.12 Amendment. This policy may be amended upon...

32 CFR 505.6 - Amendment of records.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 3 2011-07-01 2009-07-01 true Amendment of records. 505.6 Section 505.6 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS ARMY PRIVACY ACT PROGRAM § 505.6 Amendment of records. (a) Amended records. (1...

76 FR 52272 - Technical Revisions To Conform to the Caregivers and Veterans Omnibus Health Services Act of 2010

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-22

... category three, consistent with the amendment of section 1705 . Second, section 513 of the Act amended 38 U... during the Gulf War. Consistent with the statutory amendment, we are amending Sec. 17.36(a)(3) and (b)(6...

31 CFR 560.402 - Effect of amendment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Effect of amendment. 560.402 Section 560.402 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF....402 Effect of amendment. Any amendment, modification, or revocation of any section of this part or of...

31 CFR 575.402 - Effect of amendment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Effect of amendment. 575.402 Section 575.402 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... Effect of amendment. Any amendment, modification, or revocation of any section of this part or of any...

31 CFR 585.402 - Effect of amendment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Effect of amendment. 585.402 Section 585.402 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... Interpretations § 585.402 Effect of amendment. Any amendment, modification, or revocation of any section of this...

76 FR 64096 - Pennsylvania; Amendment No. 3 to Notice of a Major Disaster Declaration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-17

.... FEMA-4025-DR; Docket ID FEMA-2011-0001] Pennsylvania; Amendment No. 3 to Notice of a Major Disaster... notice of a major disaster declaration for the Commonwealth of Pennsylvania (FEMA-4025-DR), dated... disaster declaration for the Commonwealth of Pennsylvania is hereby amended to include the following areas...

75 FR 51755 - New England Fishery Management Council; Public Hearing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-23

... comments on proposals to be included in the Draft Amendment 3 to the Deep Sea Red Crab Fishery Management... to [email protected] with ``Comments on Red Crab Draft Amendment 3'' in the subject line... Council proposes to take action to amend the Deep Sea Red Crab Fishery Management Plan (FMP) and to...

SMMP v. 3.0—Simulating proteins and protein interactions in Python and Fortran

NASA Astrophysics Data System (ADS)

Meinke, Jan H.; Mohanty, Sandipan; Eisenmenger, Frank; Hansmann, Ulrich H. E.

2008-03-01

We describe a revised and updated version of the program package SMMP. SMMP is an open-source FORTRAN package for molecular simulation of proteins within the standard geometry model. It is designed as a simple and inexpensive tool for researchers and students to become familiar with protein simulation techniques. SMMP 3.0 sports a revised API increasing its flexibility, an implementation of the Lund force field, multi-molecule simulations, a parallel implementation of the energy function, Python bindings, and more. Program summaryTitle of program:SMMP Catalogue identifier:ADOJ_v3_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADOJ_v3_0.html Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland Licensing provisions:Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html Programming language used:FORTRAN, Python No. of lines in distributed program, including test data, etc.:52 105 No. of bytes in distributed program, including test data, etc.:599 150 Distribution format:tar.gz Computer:Platform independent Operating system:OS independent RAM:2 Mbytes Classification:3 Does the new version supersede the previous version?:Yes Nature of problem:Molecular mechanics computations and Monte Carlo simulation of proteins. Solution method:Utilizes ECEPP2/3, FLEX, and Lund potentials. Includes Monte Carlo simulation algorithms for canonical, as well as for generalized ensembles. Reasons for new version:API changes and increased functionality. Summary of revisions:Added Lund potential; parameters used in subroutines are now passed as arguments; multi-molecule simulations; parallelized energy calculation for ECEPP; Python bindings. Restrictions:The consumed CPU time increases with the size of protein molecule. Running time:Depends on the size of the simulated molecule.

Zeolite Combined with Alum and Polyaluminum Chloride Mixed with Agricultural Slurries Reduces Carbon Losses in Runoff from Grassed Soil Boxes.

PubMed

Murnane, J G; Brennan, R B; Fenton, O; Healy, M G

2016-11-01

Carbon (C) losses from agricultural soils to surface waters can migrate through water treatment plants and result in the formation of disinfection by-products, which are potentially harmful to human health. This study aimed to quantify total organic carbon (TOC) and total inorganic C losses in runoff after application of dairy slurry, pig slurry, or milk house wash water (MWW) to land and to mitigate these losses through coamendment of the slurries with zeolite (2.36-3.35 mm clinoptilolite) and liquid polyaluminum chloride (PAC) (10% AlO) for dairy and pig slurries or liquid aluminum sulfate (alum) (8% AlO) for MWW. Four treatments under repeated 30-min simulated rainfall events (9.6 mm h) were examined in a laboratory study using grassed soil runoff boxes (0.225 m wide, 1 m long; 10% slope): control soil, unamended slurries, PAC-amended dairy and pig slurries (13.3 and 11.7 kg t, respectively), alum-amended MWW (3.2 kg t), combined zeolite and PAC-amended dairy (160 and 13.3 kg t zeolite and PAC, respectively) and pig slurries (158 and 11.7 kg t zeolite and PAC, respectively), and combined zeolite and alum-amended MWW (72 and 3.2 kg t zeolite and alum, respectively). The unamended and amended slurries were applied at net rates of 31, 34, and 50 t ha for pig and dairy slurries and MWW, respectively. Significant reductions of TOC in runoff compared with unamended slurries were measured for PAC-amended dairy and pig slurries (52 and 56%, respectively) but not for alum-amended MWW. Dual zeolite and alum-amended MWW significantly reduced TOC in runoff compared with alum amendment only. We conclude that use of PAC-amended dairy and pig slurries and dual zeolite and alum-amended MWW, although effective, may not be economically viable to reduce TOC losses from organic slurries given the relatively low amounts of TOC measured in runoff from unamended slurries compared with the amounts applied. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

Endoventricular Deep Brain Stimulation of the Third Ventricle: Proof of Concept and Application to Cluster Headache.

PubMed

Chabardès, Stéphan; Carron, Romain; Seigneuret, Eric; Torres, Napoleon; Goetz, Laurent; Krainik, Alexandre; Piallat, Brigitte; Pham, Pascale; David, Olivier; Giraud, Pierrick; Benabid, Alim Louis

2016-12-01

The third ventricle (3rd V) is surrounded by centers related to satiety, homeostasis, hormones, sleep, memory, and pain. Stimulation of the wall of the 3rd V could be useful to treat disorders related to dysfunction of the hypothalamus. To assess safety and efficacy of endoventricular electrical stimulation of the hypothalamus using a floating deep brain stimulation (DBS) lead laid on the floor of the 3rd V to treat refractory cluster headaches (CH). Seven patients, aged 24 to 60 years, experiencing chronic CH (mean chronic duration 5.8 ± 2.5 years) were enrolled in this pilot, prospective, open study assessing the safety and potential efficacy of chronic DBS of the 3rd V. Number of attacks was collected during baseline and was compared with those occurring at 3, 6, and 12 months postoperation. Any side effects that occurred during or after surgery were reported. Effect on mood was assessed using the Hospital Anxiety and Depression scale during baseline and at 6 and 12 months postoperation. Insertion of the lead into the posterior 3rd V and chronic stimulation was feasible and safe in all patients. The voltage ranged from 0.9 to 2.3 volts. The most common side effect was transient trembling vision during stimulation. At 12 months, 3 of 7 patients were pain free, 2 had 90% improvement, 1 of 7 had 75% improvement, and 1 of 7 was not significantly improved. This proof of concept demonstrates the feasibility, safety, and potential efficacy of 3rd V DBS using an endoventricular road that could be applied to treat various diseases involving hypothalamic areas. CCH, chronic cluster headacheCH, cluster headacheDBS, deep brain stimulationHAD, hospital anxiety depressionONS, occipital nerve stimulationPAG, periaqueductal gray matterPH, posterior hypothalamusPVG, periventricular gray matter3rd V, third ventricle.

The role of IL-6 and IL-1beta in painful perineural inflammatory neuritis.

PubMed

Eliav, Eli; Benoliel, Rafael; Herzberg, Uri; Kalladka, Mythili; Tal, Michael

2009-05-01

Inflammation along a nerve trunk (perineural inflammation), without detectable axonal damage, has been shown to induce transient pain in the organ supplied by the nerve. The aims of the present study were to study the role IL-6 and IL-1beta, in pain induced by perineural inflammation. IL-6 and IL-1beta secretion from rat's sciatic nerves, L-5 Dorsal Root Ganglia (DRG), and the hind paw skin, 3 and 8 days following exposure of the nerve to Complete Freund's Adjuvant (CFA), were measured using ELISA method. Hind paw tactile-allodynia, mechano-hyperalgesia, heat-allodynia and electrical detection thresholds were tested up to 8 days following the application of CFA, IL-6 or IL-1beta adjacent to the sciatic nerve trunk. Employing electrophysiological recording, saphenous nerve spontaneous activity, nerve trunk mechano-sensitivity and paw tactile detection threshold (determined by recording action potential induced by the lowest mechanical stimulus) were assessed 3 and 8 days following exposure of the nerve trunk to CFA, IL-6, or IL-1beta. IL-6 and IL-1beta secretion from the nerve was significantly elevated on the 3rd day post-operation (DPO). On the 8th DPO, IL-6 levels returned to baseline while IL-1beta levels remained significantly elevated. The DRG cytokine's level was increased on the 3rd and 8th DPOs, contralateral cytokine's level was increased on the 3rd DPO. The skin IL-6 level was increased bilaterally on the 3rd DPO and returned to baseline on the 8th DPO. IL-1beta levels increased in the affected side on the 3rd and bilaterally on the 8th DPO. Direct application of IL-6 or CFA on the sciatic nerve induced significant hind paw tactile-allodynia from the 1st to 5th DPOs, reduced electrical detection threshold from the 1st to 3rd DPOs, mechano-hyperalgesia from 3rd to 5th DPOs and heat-allodynia on the 3rd DPO. Direct application of IL-1beta induced paw tactile and heat-allodynia on the 7-8th DPOs and mechano-hyperalgesia on the 5-8th DPOs. Perineural inflammation significantly increased spontaneous activity myelinated fibres 3 and 8 days following the application. Direct application of IL-6 induced elevation of spontaneous activity on the 3rd while IL-1beta on the 8th DPO. Nerve mechano-sensitivity was significantly increased on the 3rd day following exposure to CFA and IL-6 and on the 8th following CFA application. The rat's paw lowest mechanical force necessary for induction of action potential, was significantly reduced 3 days following CFA application. IL-6 and IL-1beta play an important role in pain induced by perineural inflammation. IL-6 activity is more prominent immediately following application (2-5th DPOs), while IL-1beta, activity is more significant in a later stage (5-8th DPOs).

Reduction of wound infections in laparoscopic-assisted colorectal resections by plastic wound ring drapes (REDWIL)?--A randomized controlled trial.

PubMed

Lauscher, J C; Grittner, F; Stroux, A; Zimmermann, M; le Claire, M; Buhr, H J; Ritz, J P

2012-10-01

Surgical site infections (SSIs) are frequent complications in colorectal surgery and may lead to burst abdomen, incisional hernia, and increased perioperative costs. Plastic wound ring drapes (RD) were introduced some decades ago to protect the abdominal wound from bacteria and reduce SSIs. There have been no controlled trials examining the benefit of RD in laparoscopic colorectal surgery. The Reduction of wound infections in laparoscopic assisted colorectal resections by plastic wound ring drapes (REDWIL) trial was thus designed to assess their effectiveness in preventing SSIs after elective laparoscopic colorectal resections. REDWIL is a randomized controlled monocenter trial with two parallel groups (experimental group with RD and control group without RD). Patients undergoing elective laparoscopic colorectal resection were included. The primary endpoint was SSIs. Secondary outcomes were colonization of the abdominal wall with bacteria, reoperations/readmissions, early/late postoperative complications, and cost of hospital stay. The duration of follow-up was 6 months. Between January 2008 and October 2010, 109 patients were randomly assigned to the experimental or control group (with or without RD). Forty-six patients in the RD group and 47 patients in the control group completed follow-up. SSIs developed in ten patients with RD (21.7 %) and six patients without RD (12.8 %) (p = 0.28). An intraoperative swab taken from the abdominal wall was positive in 66.7 % of patients with RD and 57.5 % without RD (p = 0.46). The number of species cultured within one swab was significantly higher in those without RD (p = 0.03). The median total inpatient costs including emergency readmissions were 3,402 ± 4,038 in the RD group and 3,563 ± 1,735 in the control group (p = 0.869). RD do not reduce the rate of SSIs in laparoscopic colorectal surgery. The inpatient costs are similar with and without RD.

Resolving the false-negative issues of the nonpolar organic amendment in whole-sediment toxicity identification evaluations.

PubMed

Mehler, W Tyler; Keough, Michael J; Pettigrove, Vincent

2018-04-01

Three common false-negative scenarios have been encountered with amendment addition in whole-sediment toxicity identification evaluations (TIEs): dilution of toxicity by amendment addition (i.e., not toxic enough), not enough amendment present to reduce toxicity (i.e., too toxic), and the amendment itself elicits a toxic response (i.e., secondary amendment effect). One such amendment in which all 3 types of false-negatives have been observed is with the nonpolar organic amendment (activated carbon or powdered coconut charcoal). The objective of the present study was to reduce the likelihood of encountering false-negatives with this amendment and to increase the value of the whole-sediment TIE bioassay. To do this, the present study evaluated the effects of various activated carbon additions to survival, growth, emergence, and mean development rate of Chironomus tepperi. Using this information, an alternative method for this amendment was developed which utilized a combination of multiple amendment addition ratios based on wet weight (1%, lower likelihood of the secondary amendment effect; 5%, higher reduction of contaminant) and nonconventional endpoints (emergence, mean development rate). This alternative method was then validated in the laboratory (using spiked sediments) and with contaminated field sediments. Using these multiple activated carbon ratios in combination with additional endpoints (namely, emergence) reduced the likelihood of all 3 types of false-negatives and provided a more sensitive evaluation of risk. Environ Toxicol Chem 2018;37:1219-1230. © 2017 SETAC. © 2017 SETAC.

Pharmacokinetic properties of tandem d-peptides designed for treatment of Alzheimer's disease.

PubMed

Leithold, Leonie H E; Jiang, Nan; Post, Julia; Niemietz, Nicole; Schartmann, Elena; Ziehm, Tamar; Kutzsche, Janine; Shah, N Jon; Breitkreutz, Jörg; Langen, Karl-Josef; Willuweit, Antje; Willbold, Dieter

2016-06-30

Peptides are more and more considered for the development of drug candidates. However, they frequently exhibit severe disadvantages such as instability and unfavourable pharmacokinetic properties. Many peptides are rapidly cleared from the organism and oral bioavailabilities as well as in vivo half-lives often remain low. In contrast, some peptides consisting solely of d-enantiomeric amino acid residues were shown to combine promising therapeutic properties with high proteolytic stability and enhanced pharmacokinetic parameters. Recently, we have shown that D3 and RD2 have highly advantageous pharmacokinetic properties. Especially D3 has already proven promising properties suitable for treatment of Alzheimer's disease. Here, we analyse the pharmacokinetic profiles of D3D3 and RD2D3, which are head-to-tail tandem d-peptides built of D3 and its derivative RD2. Both D3D3 and RD2D3 show proteolytic stability in mouse plasma and organ homogenates for at least 24h and in murine and human liver microsomes for 4h. Notwithstanding their high affinity to plasma proteins, both peptides are taken up into the brain following i.v. as well as i.p. administration. Although both peptides contain identical d-amino acid residues, they are arranged in a different sequence order and the peptides show differences in pharmacokinetic properties. After i.p. administration RD2D3 exhibits lower plasma clearance and higher bioavailability than D3D3. We therefore concluded that the amino acid sequence of RD2 leads to more favourable pharmacokinetic properties within the tandem peptide, which underlines the importance of particular sequence motifs, even in short peptides, for the design of further therapeutic d-peptides. Copyright © 2016 Elsevier B.V. All rights reserved.

Efficacy of Organic Soil Amendments for Management of Heterodera glycines in Greenhouse Experiments.

PubMed

Grabau, Zane J; Chen, Senyu

2014-09-01

In a repeated greenhouse experiment, organic soil amendments were screened for effects on population density of soybean cyst nematode (SCN), Heterodera glycines, and soybean growth. Ten amendments at various rates were tested: fresh plant material of field pennycress, marigold, spring camelina, and Cuphea; condensed distiller's solubles (CDS), ash of combusted CDS, ash of combusted turkey manure (TMA), marigold powder, canola meal, and pennycress seed powder. Soybeans were grown for 70 d in field soil with amendments and SCN eggs incorporated at planting. At 40 d after planting (DAP), many amendments reduced SCN egg population density, but some also reduced plant height. Cuphea plant at application rate of 2.9% (amendment:soil, w:w, same below), marigold plant at 2.9%, pennycress seed powder at 0.5%, canola meal at 1%, and CDS at 4.3% were effective against SCN with population reductions of 35.2%, 46.6%, 46.7%, 73.2%, and 73.3% compared with control, respectively. For Experiment 1 at 70 DAP, canola meal at 1% and pennycress seed powder at 0.5% reduced SCN population density 70% and 54%, respectively. CDS at 4.3%, ash of CDS at 0.2%, and TMA at 1% increased dry plant mass whereas CDS at 4.3% and pennycress seed powder at 0.1% reduced plant height. For Experiment 2 at 70 DAP, amendments did not affect SCN population nor plant growth. In summary, some amendments were effective for SCN management, but phytoxicity was a concern.

Efficacy of Organic Soil Amendments for Management of Heterodera glycines in Greenhouse Experiments

PubMed Central

Grabau, Zane J.; Chen, Senyu

2014-01-01

In a repeated greenhouse experiment, organic soil amendments were screened for effects on population density of soybean cyst nematode (SCN), Heterodera glycines, and soybean growth. Ten amendments at various rates were tested: fresh plant material of field pennycress, marigold, spring camelina, and Cuphea; condensed distiller’s solubles (CDS), ash of combusted CDS, ash of combusted turkey manure (TMA), marigold powder, canola meal, and pennycress seed powder. Soybeans were grown for 70 d in field soil with amendments and SCN eggs incorporated at planting. At 40 d after planting (DAP), many amendments reduced SCN egg population density, but some also reduced plant height. Cuphea plant at application rate of 2.9% (amendment:soil, w:w, same below), marigold plant at 2.9%, pennycress seed powder at 0.5%, canola meal at 1%, and CDS at 4.3% were effective against SCN with population reductions of 35.2%, 46.6%, 46.7%, 73.2%, and 73.3% compared with control, respectively. For Experiment 1 at 70 DAP, canola meal at 1% and pennycress seed powder at 0.5% reduced SCN population density 70% and 54%, respectively. CDS at 4.3%, ash of CDS at 0.2%, and TMA at 1% increased dry plant mass whereas CDS at 4.3% and pennycress seed powder at 0.1% reduced plant height. For Experiment 2 at 70 DAP, amendments did not affect SCN population nor plant growth. In summary, some amendments were effective for SCN management, but phytoxicity was a concern. PMID:25276000

7 CFR 380.1 - Scope and applicability of rules of practice.

Code of Federal Regulations, 2014 CFR

2014-01-01

...) The Plant Protection Act, section 424 (7 U.S.C. 7734), (2) Endangered Species Act Amendments of 1973, as amended, section 11(a), 16 U.S.C. 1540(a), and (3) Lacey Act Amendments of 1981, as amended... INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER CERTAIN ACTS...

7 CFR 380.1 - Scope and applicability of rules of practice.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) The Plant Protection Act, section 424 (7 U.S.C. 7734), (2) Endangered Species Act Amendments of 1973, as amended, section 11(a), 16 U.S.C. 1540(a), and (3) Lacey Act Amendments of 1981, as amended... INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER CERTAIN ACTS...

7 CFR 380.1 - Scope and applicability of rules of practice.

Code of Federal Regulations, 2012 CFR

2012-01-01

...) The Plant Protection Act, section 424 (7 U.S.C. 7734), (2) Endangered Species Act Amendments of 1973, as amended, section 11(a), 16 U.S.C. 1540(a), and (3) Lacey Act Amendments of 1981, as amended... INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER CERTAIN ACTS...

7 CFR 380.1 - Scope and applicability of rules of practice.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) The Plant Protection Act, section 424 (7 U.S.C. 7734), (2) Endangered Species Act Amendments of 1973, as amended, section 11(a), 16 U.S.C. 1540(a), and (3) Lacey Act Amendments of 1981, as amended... INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER CERTAIN ACTS...

7 CFR 380.1 - Scope and applicability of rules of practice.

Code of Federal Regulations, 2013 CFR

2013-01-01

...) The Plant Protection Act, section 424 (7 U.S.C. 7734), (2) Endangered Species Act Amendments of 1973, as amended, section 11(a), 16 U.S.C. 1540(a), and (3) Lacey Act Amendments of 1981, as amended... INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER CERTAIN ACTS...

41 CFR 105-64.401 - Can I amend my record?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Can I amend my record? 105-64.401 Section 105-64.401 Public Contracts and Property Management Federal Property Management... to amend your record by writing to the system manager with the proposed amendment. Mark both the...

41 CFR 105-64.401 - Can I amend my record?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Can I amend my record? 105-64.401 Section 105-64.401 Public Contracts and Property Management Federal Property Management... to amend your record by writing to the system manager with the proposed amendment. Mark both the...

41 CFR 105-64.401 - Can I amend my record?

Code of Federal Regulations, 2014 CFR

2014-01-01

... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Can I amend my record? 105-64.401 Section 105-64.401 Public Contracts and Property Management Federal Property Management... to amend your record by writing to the system manager with the proposed amendment. Mark both the...

41 CFR 105-64.401 - Can I amend my record?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Can I amend my record? 105-64.401 Section 105-64.401 Public Contracts and Property Management Federal Property Management... to amend your record by writing to the system manager with the proposed amendment. Mark both the...

36 CFR 1202.76 - Can NARA deny my request for amendment?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Can NARA deny my request for amendment? 1202.76 Section 1202.76 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... Can NARA deny my request for amendment? If the system manager denies your request to amend or...

75 FR 39145 - Amendment of Class C Airspace; Flint, MI

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-08

...-0599; Airspace Docket No. 10-AWA-3] RIN 2120-AA66 Amendment of Class C Airspace; Flint, MI AGENCY... description of the Bishop International Airport, Flint, MI, Class C airspace area by amending the airport... defines the Class C airspace area's center point. The Rule This action amends Title 14 Code of Federal...

RD2-MolPack-Chim3, a packaging cell line for stable production of lentiviral vectors for anti-HIV gene therapy.

PubMed

Stornaiuolo, Anna; Piovani, Bianca Maria; Bossi, Sergio; Zucchelli, Eleonora; Corna, Stefano; Salvatori, Francesca; Mavilio, Fulvio; Bordignon, Claudio; Rizzardi, Gian Paolo; Bovolenta, Chiara

2013-08-01

Over the last two decades, several attempts to generate packaging cells for lentiviral vectors (LV) have been made. Despite different technologies, no packaging clone is currently employed in clinical trials. We developed a new strategy for LV stable production based on the HEK-293T progenitor cells; the sequential insertion of the viral genes by integrating vectors; the constitutive expression of the viral components; and the RD114-TR envelope pseudotyping. We generated the intermediate clone PK-7 expressing constitutively gag/pol and rev genes and, by adding tat and rd114-tr genes, the stable packaging cell line RD2-MolPack, which can produce LV carrying any transfer vector (TV). Finally, we obtained the RD2-MolPack-Chim3 producer clone by transducing RD2-MolPack cells with the TV expressing the anti-HIV transgene Chim3. Remarkably, RD114-TR pseudovirions have much higher potency when produced by stable compared with transient technology. Most importantly, comparable transduction efficiency in hematopoietic stem cells (HSC) is obtained with 2-logs less physical particles respect to VSV-G pseudovirions produced by transient transfection. Altogether, RD2-MolPack technology should be considered a valid option for large-scale production of LV to be used in gene therapy protocols employing HSC, resulting in the possibility of downsizing the manufacturing scale by about 10-fold in respect to transient technology.

9 CFR 202.103 - Rule 3: Beginning a reparation proceeding.

Code of Federal Regulations, 2010 CFR

2010-01-01

... cause of action; and (3) After the first amendment, or after the filing of an answer by the respondent... amendment to the complaint. (d) Where to file. The complaint should be transmitted or delivered to any area... to be received by the Department when it is received by such employee. (f) Amendment. The complaint...

9 CFR 202.103 - Rule 3: Beginning a reparation proceeding.

Code of Federal Regulations, 2012 CFR

2012-01-01

... cause of action; and (3) After the first amendment, or after the filing of an answer by the respondent... amendment to the complaint. (d) Where to file. The complaint should be transmitted or delivered to any area... to be received by the Department when it is received by such employee. (f) Amendment. The complaint...

9 CFR 202.103 - Rule 3: Beginning a reparation proceeding.

Code of Federal Regulations, 2011 CFR

2011-01-01

... cause of action; and (3) After the first amendment, or after the filing of an answer by the respondent... amendment to the complaint. (d) Where to file. The complaint should be transmitted or delivered to any area... to be received by the Department when it is received by such employee. (f) Amendment. The complaint...

9 CFR 202.103 - Rule 3: Beginning a reparation proceeding.

Code of Federal Regulations, 2013 CFR

2013-01-01

... cause of action; and (3) After the first amendment, or after the filing of an answer by the respondent... amendment to the complaint. (d) Where to file. The complaint should be transmitted or delivered to any area... to be received by the Department when it is received by such employee. (f) Amendment. The complaint...

9 CFR 202.103 - Rule 3: Beginning a reparation proceeding.

Code of Federal Regulations, 2014 CFR

2014-01-01

... cause of action; and (3) After the first amendment, or after the filing of an answer by the respondent... amendment to the complaint. (d) Where to file. The complaint should be transmitted or delivered to any area... to be received by the Department when it is received by such employee. (f) Amendment. The complaint...

75 FR 32493 - Minnesota; Amendment No. 3 to Notice of a Major Disaster Declaration

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

.... FEMA-1900-DR; Docket ID FEMA-2010-0002] Minnesota; Amendment No. 3 to Notice of a Major Disaster... notice of a major disaster declaration for the State of Minnesota (FEMA-1900-DR), dated April 19, 2010... the State of Minnesota is hereby amended to include the following area among those areas determined to...

76 FR 58027 - Puerto Rico; Amendment No. 3 to Notice of a Major Disaster Declaration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-19

.... FEMA-4017-DR; Docket ID FEMA-2011-0001] Puerto Rico; Amendment No. 3 to Notice of a Major Disaster... notice of a major disaster declaration for the Commonwealth of Puerto Rico (FEMA-4017-DR), dated August... disaster declaration for the Commonwealth of Puerto Rico is hereby amended to include the following areas...

The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation

PubMed Central

Choi, Won-Il; Jeon, Bu-Nam; Yoon, Jae-Hyeon; Koh, Dong-In; Kim, Myung-Hwa; Yu, Mi-Young; Lee, Kyung-Mi; Kim, Youngsoo; Kim, Kyunggon; Hur, Sujin Susanne; Lee, Choong-Eun; Kim, Kyung-Sup; Hur, Man-Wook

2013-01-01

The tumour-suppressor gene CDKN1A (encoding p21Waf/Cip1) is thought to be epigenetically repressed in cancer cells. FBI-1 (ZBTB7A) is a proto-oncogenic transcription factor repressing the alternative reading frame and p21WAF/CDKN1A genes of the p53 pathway. FBI-1 interacts directly with MBD3 (methyl-CpG–binding domain protein 3) in the nucleus. We demonstrated that FBI-1 binds both non-methylated and methylated DNA and that MBD3 is recruited to the CDKN1A promoter through its interaction with FBI-1, where it enhances transcriptional repression by FBI-1. FBI-1 also interacts with the co-repressors nuclear receptor corepressor (NCoR), silencing mediator for retinoid and thyroid receptors (SMRT) and BCL-6 corepressor (BCoR) to repress transcription. MBD3 regulates a molecular interaction between the co-repressor and FBI-1. MBD3 decreases the interaction between FBI-1 and NCoR/SMRT but increases the interaction between FBI-1 and BCoR. Because MBD3 is a subunit of the Mi-2 autoantigen (Mi-2)/nucleosome remodelling and histone deacetylase (NuRD)-HDAC complex, FBI-1 recruits the Mi-2/NuRD-HDAC complex via MBD3. BCoR interacts with the Mi-2/NuRD-HDAC complex, DNMTs and HP1. MBD3 and BCoR play a significant role in the recruitment of the Mi-2/NuRD-HDAC complex– and the NuRD complex–associated proteins, DNMTs and HP. By recruiting DNMTs and HP1, Mi-2/NuRD-HDAC complex appears to play key roles in epigenetic repression of CDKN1A by DNA methylation. PMID:23658227

Can the provision of a home help service for the elderly population reduce the incidence of fall-related injuries? A quasi-experimental study of the community-level effects on hospital admissions in Swedish municipalities.

PubMed

Bonander, Carl; Gustavsson, Johanna; Nilson, Finn

2016-12-01

Fall-related injuries are a global public health problem, especially in elderly populations. The effect of an intervention aimed at reducing the risk of falls in the homes of community-dwelling elderly persons was evaluated. The intervention mainly involves the performance of complicated tasks and hazards assessment by a trained assessor, and has been adopted gradually over the last decade by 191 of 290 Swedish municipalities. A quasi-experimental design was used where intention-to-treat effect estimates were derived using panel regression analysis and a regression discontinuity (RD) design. The outcome measure was the incidence of fall-related hospitalisations in the treatment population, the age of which varied by municipality (≥65 years, ≥67 years, ≥70 years or ≥75 years). We found no statistically significant reductions in injury incidence in the panel regression (IRR 1.01 (95% CI 0.98 to 1.05)) or RD (IRR 1.00 (95% CI 0.97 to 1.03)) analyses. The results are robust to several different model specifications, including segmented panel regression analysis with linear trend change and community fixed effects parameters. It is unclear whether the absence of an effect is due to a low efficacy of the services provided, or a result of low adherence. Additional studies of the effects on other quality-of-life measures are recommended before conclusions are drawn regarding the cost-effectiveness of the provision of home help service programmes. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Forty years of economic growth and plummeting mortality: the mortality experience of the poorly educated in South Korea.

PubMed

Bahk, Jinwook; Lynch, John W; Khang, Young-Ho

2017-03-01

South Korea has experienced rapid economic development and a substantial increase in life expectancy in an extremely short period. Whether this rapid development has been able to adequately address inequalities in health in South Korea may have important policy implications. This paper explores long-term trends in inequalities in mortality related to education in South Korea between 1970 and 2010. We used secondary data on population size and deaths in 1970 and 1980 from a previously published study, and census and death certificate data from Statistics Korea from 1990, 1995, 2000, 2005 and 2010. Trends in age-standardised mortality rates for men and women aged 25-64 according to education, as well as the rate ratio (RR), rate difference (RD), relative index of inequality (RII) and slope index of inequality (SII), were examined over the period 1970-2010. Despite overall mortality declines of 70-80% in the past 4 decades, educational inequalities have increased or been stagnant. There was minimal decline in mortality since 1970 in South Koreans with only a primary or lower level of education. The RR and RD between tertiary education and primary or lower education increased over the study period, while the RII and the SII in both genders remained stable. The South Korean experience over the past 40 years suggests that plummeting mortality rates and huge advances in education at the population level do not translate into reduced educational inequalities in mortality. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Graduated Driver Licensing

PubMed Central

Bates, Lyndel J.; Allen, Siobhan; Armstrong, Kerry; Watson, Barry; King, Mark J.; Davey, Jeremy

2014-01-01

Graduated driver licensing (GDL) aims to gradually increase the exposure of new drivers to more complex driving situations and typically consists of learner, provisional and open licence phases. The first phase, the learner licence, is designed to allow novice drivers to obtain practical driving experience in lower risk situations. The learner licence can delay licensure, encourage novice drivers to learn under supervision, mandate the number of hours of practice required to progress to the next phase and encourage parental involvement. The second phase, the provisional licence, establishes various driving restrictions and thereby reduces exposure to situations of higher risk, such as driving at night, with passengers or after drinking alcohol. Parental involvement with a GDL system appears essential in helping novices obtain sufficient practice and in enforcing compliance with restrictions once the new driver obtains a provisional licence. Given the significant number of young drivers involved in crashes within Oman, GDL is one countermeasure that may be beneficial in reducing crash risk and involvement for this group. PMID:25364543

Evaluation of calcium-bearing material for treatment of CO2 leakage-induced pollution

NASA Astrophysics Data System (ADS)

Park, J.; Park, M.; Jeong, H. Y.

2017-12-01

Several Ca2+-bearing materials were evaluated for their capability to treat CO2 leakage-induced pollution for the application of permeable reactive barriers (PRBs). In this regard, a series of batch experiments were carried out with Portland cement, quick lime (CaO), and gypsum (CaSO4). Each of these materials was added to 50 mL of CO2-saturated solutions ( 7.5-8.5 mM) in serum vials sealed with Teflon-coated grey butyl stopper. Subsequently, the resultant batches were agitated at room temperature for 24 h. At predetermined intervals, each vial was sacrificed to monitor changes in pH, EC, and dissolved CO2 concentration. Despite the pH-neutralizing capacity, 0.15 g of Portland cement did not lower any dissolved CO2. When amended with 0.05 g of Ca(OH)2 or Mg(OH)2, the cement at this loading could sequester dissolved CO2, with the former being more effective. Even without such amendments, the cement at or greater than 0.2 g was shown to completely sequester dissolved CO2. In case of quick lime, its loading as low as 0.05 g instantaneously removed all dissolved CO2, which was also noted for Portland cement at 0.5 g. For gypsum, its loading at 0.12 g was not effective for immobilizing dissolved CO2. By both X-ray diffraction (XRD) and thermogravimetry (TG) analyses, the CO2 sequestration by Ca2+-bearing materials was found to be mainly due to the formation of calcite (CaCO3). Funding source: The "R&D Project on Environmental Management of Geologic CO2 Storage" from the KEITI (Project Number: 2014001810003).

Construction of SO(5)⊃SO(3) spherical harmonics and Clebsch-Gordan coefficients

NASA Astrophysics Data System (ADS)

Caprio, M. A.; Rowe, D. J.; Welsh, T. A.

2009-07-01

The SO(5)⊃SO(3) spherical harmonics form a natural basis for expansion of nuclear collective model angular wave functions. They underlie the recently-proposed algebraic method for diagonalization of the nuclear collective model Hamiltonian in an SU(1,1)×SO(5) basis. We present a computer code for explicit construction of the SO(5)⊃SO(3) spherical harmonics and use them to compute the Clebsch-Gordan coefficients needed for collective model calculations in an SO(3)-coupled basis. With these Clebsch-Gordan coefficients it becomes possible to compute the matrix elements of collective model observables by purely algebraic methods. Program summaryProgram title: GammaHarmonic Catalogue identifier: AECY_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AECY_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 346 421 No. of bytes in distributed program, including test data, etc.: 16 037 234 Distribution format: tar.gz Programming language: Mathematica 6 Computer: Any which supports Mathematica Operating system: Any which supports Mathematica; tested under Microsoft Windows XP and Linux Classification: 4.2 Nature of problem: Explicit construction of SO(5) ⊃ SO(3) spherical harmonics on S. Evaluation of SO(3)-reduced matrix elements and SO(5) ⊃ SO(3) Clebsch-Gordan coefficients (isoscalar factors). Solution method: Construction of SO(5) ⊃ SO(3) spherical harmonics by orthonormalization, obtained from a generating set of functions, according to the method of Rowe, Turner, and Repka [1]. Matrix elements and Clebsch-Gordan coefficients follow by construction and integration of SO(3) scalar products. Running time: Depends strongly on the maximum SO(5) and SO(3) representation labels involved. A few minutes for the calculation in the Mathematica notebook. References: [1] D.J. Rowe, P.S. Turner, J. Repka, J. Math. Phys. 45 (2004) 2761.

Abortion legislation, maternal healthcare, fertility, female literacy, sanitation, violence against women and maternal deaths: a natural experiment in 32 Mexican states.

PubMed

Koch, Elard; Chireau, Monique; Pliego, Fernando; Stanford, Joseph; Haddad, Sebastian; Calhoun, Byron; Aracena, Paula; Bravo, Miguel; Gatica, Sebastián; Thorp, John

2015-02-23

To test whether there is an association between abortion legislation and maternal mortality outcomes after controlling for other factors thought to influence maternal health. Population-based natural experiment. Official maternal mortality data from 32 federal states of Mexico between 2002 and 2011. Maternal mortality ratio (MMR), MMR with any abortive outcome (MMRAO) and induced abortion mortality ratio (iAMR). Abortion legislation grouped as less (n=18) or more permissive (n=14); constitutional amendment protecting the unborn (n=17); skilled attendance at birth; all-abortion hospitalisation ratio; low birth weight rate; contraceptive use; total fertility rates (TFR); clean water; sanitation; female literacy rate and intimate-partner violence. Over the 10-year period, states with less permissive abortion legislation exhibited lower MMR (38.3 vs 49.6; p<0.001), MMRAO (2.7 vs 3.7; p<0.001) and iAMR (0.9 vs 1.7; p<0.001) than more permissive states. Multivariate regression models estimating effect sizes (β-coefficients) for mortality outcomes showed independent associations (p values between 0.001 and 0.055) with female literacy (β=-0.061 to -1.100), skilled attendance at birth (β=-0.032 to -0.427), low birth weight (β=0.149 to 2.166), all-abortion hospitalisation ratio (β=-0.566 to -0.962), clean water (β=-0.048 to -0.730), sanitation (β=-0.052 to -0.758) and intimate-partner violence (β=0.085 to 0.755). TFR showed an inverse association with MMR (β=-14.329) and MMRAO (β=-1.750) and a direct association with iAMR (β=1.383). Altogether, these factors accounted for (R(2)) 51-88% of the variance among states in overall mortality rates. No statistically independent effect was observed for abortion legislation, constitutional amendment or other covariates. Although less permissive states exhibited consistently lower maternal mortality rates, this finding was not explained by abortion legislation itself. Rather, these differences were explained by other independent factors, which appeared to have a more favourable distribution in these states. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Superfund Record of Decision Amendment (EPA Region 6): Texarkana Wood Preserving Co. , Texarkana, TX, March 13, 1998

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This decision document presents an amendment to the selected remedial action for the Texarkana Wood Preserving Co. Superfund Site. This amendment fundamentally changes the Record of Decision (ROD) executed by the Regional Administrator on September 25, 1990. This amended remedy will seal and contain soils contaminated with greater than 3 ppm (parts per million) benzo(a)pyrene equivalents, 2450 ppm total poly aromatic hydrocarbons (PAH), 20 ppb (parts per billion) as 2,3,7,8 TCDD equivalents and 150 ppm pentachlorophenol beneath a soil cap.

Dehydrogenase activity and quality of leachates in Technosols with gossan and sulfide materials from the São Domingos mine

NASA Astrophysics Data System (ADS)

Santos, Erika; Abreu, Manuela; Macías, Felipe; de Varennes, Amarílis

2014-05-01

Wastes produced by mining activity in São Domingos (Portuguese Iberian Pyrite Belt) were disposed over a large area. To speed up the ecological rehabilitation in this mine, an integrative strategy using different amendments+mine wastes was used to produce Technosols with enhanced soil functions. To evaluate the efficiency of these Technosols the dehydrogenase activity and chemical quality of leachates were monitored. Technosols were composed of different mine wastes (gossan and sulfide materials), collected at the São Domingos mine, and mixtures of amendments applied at 30 and 75 Mg/ha (rockwool+agriculture wastes+wastes from liquors distillation of strawberry tree fruits (Arbutus unedo L.) and/or carobs (Ceratonia siliqua L. fruits)). Three assays, under controlled conditions, were carried out: (1 and 2) Sulfide or gossan materials with/without amendments; (3) Sulfide wastes, with/without amendments, incubated during four months and then with application of an overlayer of gossan (~3 cm thick) with/without the same amendments. Dehydrogenase activity (DHA) and chemical characteristics of leachates (multielemental concentration, pH, and electric conductivity) were determined after four/seven/thirteen months of incubation. Sulfide wastes had more hazardous characteristics (pH~2 and total concentrations (g/kg) of Al (58.1), As (1.1), Cu (2.1), Fe (107.3), Pb (11.7), S (65.3) and Zn (1.1) than the gossan materials (pH=4.3; g/kg, Al: 24.8, As: 3.0, Cu: 0.2, Fe: 129, Pb: 9.2, S: 13.7, Zn: 0.04). Amendments application to gossan (assay 2) enhanced DHA in both sampling periods (µg TPF g dry weight 16 h-1, Control: 0,72-1,78; Amended treatments: 2.49-16.36 depending on mixture/application rate/sampling period). Greater application rates stimulated DHA (more than 1.5-fold with 75 Mg/ha). No differences were observed in DHA in the gossan layer with/without amendments (assay 3) suggesting a negative impact on gossan microrganisms from sulfide materials located below. In fact, for sulfide materials (assays 1 and 3), the amendments did not lead to increases in DHA (µg TPF g dry weight 16 h-1, Control: 0.87-2.72; Amended treatments: 0.23-2.11, depending on assay/sampling period/treatment). In assay 3, the DHA of each mine waste presented, in general, smaller enzymatic activity compared to the same treatments from the other assays. The amendments reduced the electrical condutivity (35-60 %) in the leachates from Technosols with sulfide materials but the pH of leachates increased in all cases between 0.5 and 1.5 units, depending on assay/treatment/sampling period.

Cosmetic breast surgery - discharge

MedlinePlus

... Higdon KK. Reduction mammaplasty. In: Neligan PC, ed. Plastic Surgery . 3rd ed. Philadelphia, PA: Elsevier Saunders; 2013: ... Gabriel A. Breast augmentation. In: Neligan PC, ed. Plastic Surgery . 3rd ed. Philadelphia, PA: Elsevier Saunders; 2013: ...

29 CFR 779.200 - Coverage expanded by 1961 and 1966 amendments.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Coverage Enterprise; the Business Unit § 779.200 Coverage expanded by 1961 and 1966 amendments. The 1961 amendments for the first time since the enactment of the Fair Labor Standards Act of 1938 provided that all... 29 Labor 3 2014-07-01 2014-07-01 false Coverage expanded by 1961 and 1966 amendments. 779.200...

45 CFR 613.4 - Amendment of records.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Amendment of records. 613.4 Section 613.4 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PRIVACY ACT REGULATIONS § 613.4 Amendment of records. (a) Where to make a request. An individual may request amendment of records pertaining to him or her that are...

45 CFR 613.4 - Amendment of records.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 3 2011-10-01 2011-10-01 false Amendment of records. 613.4 Section 613.4 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PRIVACY ACT REGULATIONS § 613.4 Amendment of records. (a) Where to make a request. An individual may request amendment of records pertaining to him or her that are...

41 CFR 105-64.401 - Can I amend my record?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Can I amend my record? 105-64.401 Section 105-64.401 Public Contracts and Property Management Federal Property Management... Administration 64-GSA PRIVACY ACT RULES 64.4-Amending Records § 105-64.401 Can I amend my record? You may request...

49 CFR 1007.8 - Amendment of a record.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 8 2010-10-01 2010-10-01 false Amendment of a record. 1007.8 Section 1007.8... § 1007.8 Amendment of a record. (a) Any individual may request amendment of information pertaining to him... specified in §§ 1007.3 and 1007.4 in order to simplify identification of the record and permit verification...

Characteristics of Internal Medicine Physicians Disciplined by Professional Colleges in Canada

PubMed Central

Liu, Jessica J.; Alam, Asim Q.; Goldberg, Hanna R.; Matelski, John Justin; Bell, Chaim M.

2015-01-01

Abstract Physician misconduct is of serious concern to patient safety and quality of care. Currently, there are limited data on disciplinary proceedings involving internal medicine (IM) physicians. The aim of this study was to investigate the number and nature of disciplinary cases among IM physicians compared with those of other disciplined physicians. Our retrospective study reviewed information from all provincial Colleges of Physicians and Surgeons (CPS) and compiled a database of all disciplined physicians from 2000 to 2013 in Canada. Disciplinary rate differences (RDs) were calculated for IM physicians and compared with other physicians. From 2000 to 2013, overall disciplinary rates were low (9.6 cases per 10,000 physician years). There were 899 disciplinary cases, 49 of which involved 45 different IM physicians. IM physicians comprised 10.8% of all disciplined physicians and were disciplined at a lower rate than non-IM physicians, incurring 5.18 fewer cases per 10,000 physician years than other physicians (95% confidence interval [CI] 3.62–6.73; P < 0.001). They were significantly less likely to be disciplined for: unprofessional conduct (RD 1.16; CI 0.45–1.87; P = 0.001); unlicensed activity (RD 0.78; CI 0.37–1.19; P < 0.001); standard of care issues (RD 1.37; CI 0.49–2.26; P = 0.002); sexual misconduct (RD 1.65; CI 0.90–2.40; P < 0.001); miscellaneous (RD 0.80; CI 0.11–1.50; P = 0.020); mental illness (RD 0.06; CI 0.01–0.12; P = 0.025); inappropriate prescribing (RD 0.74; CI 0.15–1.33; P = 0.010); and criminal conviction (RD 0.33; CI 0.00–0.65; P = 0.048). No significant differences were found with respect to unclear violations, fraudulent behavior/prevarication, or offenses involving drugs/alcohol (all RDs less than 0.32). IM physicians were also less likely to incur the following penalties: voluntary license surrender (RD 0.53; CI 0.37–0.69; P < 0.001); suspension (RD 2.39; CI 1.26–3.51; P < 0.001); retraining/assessment (RD 1.58; CI 0.77–2.39; P < 0.001); restriction (RD 1.60; CI 0.74–2.46; P < 0.001); other (RD 0.52; CI 0.07–0.97; P = 0.030); formal reprimand (RD 2.78; CI 1.77–3.79; P < 0.001); or fine (RD 3.28; CI 1.89–4.67; P < 0.001). No significant differences were found with respect to revocation or mandated counseling/rehabilitation (all RDs less than 0.46). Generally, disciplinary rates among physicians were low. Compared with other physicians, IM physicians have significantly lower disciplinary rates overall and are less likely to incur the majority of disciplinary offenses and penalties. PMID:26131839

Handbook for designing roadways for the aging population.

DOT National Transportation Integrated Search

2014-06-01

The original Older Driver Highway Design Handbook was published by FHWA in 1998 (FHWA-RD-97-135). The : 2nd edition, titled Highway Design Handbook for Older Drivers and Pedestrians (FHWA-RD-01-103) was published in : 2001. This 3rd edition, under a ...

Structural analysis of reactionary dentin formed in response to polymicrobial invasion

PubMed Central

Charadram, Nattida; Austin, Christine; Trimby, Patrick; Simonian, Mary; Swain, Michael V.; Hunter, Neil

2013-01-01

In response to microbial invasion of dentin odontoblasts secrete an altered calcified matrix termed reactionary dentin (Rd). 3D reconstruction of focused-ion-beam scanning electron microscopy (FIB-SEM) image slices revealed helical tubular structures in Rd that contrasted with regular cylindrical tubules characteristic of dentin from healthy teeth and affected so-called physiological dentin (Pd) lying exterior to Rd. This helical structure in Rd provided effective constriction of tubule lumen diameter that formed a barrier to bacterial advance towards the dental pulp. SEM of resin cast preparations revealed altered extension of odontoblast processes through Rd. The distribution of key mineral elements was studied by combination of 3D reconstruction of focused-ion-beam based X-ray microanalysis (FIB-EDS), laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) and diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS). There was a marked redistribution of calcium and phosphorous in Rd together with an increase of diffusely deposited magnesium compatible with the mineral deposition phase of synthesis of this altered matrix. Changes in tubule structure and mineral content characteristic of Rd are consistent with reduced hardness and lower elastic modulus reported for this matrix. Findings provide insight into the unique structure of Rd synthesised as a primary response to infection. PMID:23261402

3 CFR 13499 - Executive Order 13499 of February 5, 2009. Further Amendments to Executive Order 12835...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 3 The President 1 2010-01-01 2010-01-01 false Executive Order 13499 of February 5, 2009. Further Amendments to Executive Order 12835, Establishment of the National Economic Council 13499 Order 13499 Presidential Documents Executive Orders Executive Order 13499 of February 5, 2009 EO 13499 Further Amendments to Executive Order 12835, Establishmen...

3 CFR 13500 - Executive Order 13500 of February 5, 2009. Further Amendments to Executive Order 12859...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 3 The President 1 2010-01-01 2010-01-01 false Executive Order 13500 of February 5, 2009. Further Amendments to Executive Order 12859, Establishment of the Domestic Policy Council 13500 Order 13500 Presidential Documents Executive Orders Executive Order 13500 of February 5, 2009 EO 13500 Further Amendments to Executive Order 12859, Establishment...

76 FR 19307 - Privacy Act of 1974; Amendment of Privacy Act System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-07

... accordance with the Privacy Act of 1974, as amended, the U.S. Department of Agriculture (USDA) is amending an existing Forest Service Privacy Act system of records, USDA/FS-3, Uniform Allowance System. DATES: Comments must be received in writing, on or before May 9, 2011. The System of Records USDA/FS-3 Uniform...

The diagnostic utility of 3D-ESI rotating and moving dipole methodology in the pre-surgical evaluation of MRI-negative childhood epilepsy due to focal cortical dysplasia.

PubMed

Russo, Angelo; Lallas, Matt; Jayakar, Prasanna; Miller, Ian; Hyslop, Ann; Dunoyer, Catalina; Resnick, Trevor; Duchowny, Michael

2016-09-01

This study investigates whether a combined rotating dipole (RD) and moving dipole (MD) solution enhances three-dimensional electroencephalography (EEG) source imaging (3D-ESI) localization in magnetic resonance imaging (MRI)-negative pediatric patients with focal cortical dysplasia (FCD). We retrospectively selected 14 MRI-negative patients with FCD from a cohort of 60 pediatric patients previously used to evaluate the diagnostic utility of 3D-ESI in epilepsy surgery. Patients were younger than 18 years at time of surgery and had at least 1 year of outcome data. RD and MD models were constructed for each interictal spike or sharp wave, and it was determined whether each inverse algorithm localized within the surgical resection cavity (SRC). We also compared the 3D-ESI findings and surgical outcome with positron emission tomography (PET) and ictal single photon emission computed tomography (iSPECT). RD analyses revealed a high concordance with the SRC (78.6%), particularly for temporal lobe resection (100.0%), and showed superior localization compared to PET and iSPECT, with the highest correlation in FCD type I and temporal lobe resection. Furthermore, the RD method was superior to iSPECT in FCD type II cases and to PET in extratemporal resections. RD and MD results were comparable, but in 18.2% of patients with FCD type I with localizing RDs, the MD solution was only partially within the SRC; in all of these patients 3D-ESI also correlated with superior surgical outcome compared to PET and iSPECT, especially when RD and MD solutions were analyzed together. 3D-ESI in MRI-negative cases showed superior localization compared to iSPECT or PET, especially in FCD type I and temporal lobe epilepsy, and correlated with superior surgical outcome compared to iSPECT and PET at 1 year and 2 years postoperatively, especially when RD and MD solutions were analyzed together. These findings suggest that 3D-ESI based on a combined RD-MD solution improves surgical accuracy in MRI-negative patients with FCD. Wiley Periodicals, Inc. © 2016 International League Against Epilepsy.

A new putative deltapartitivirus recovered from Dianthus amurensis.

PubMed

An, Hongliu; Tan, Guanlin; Xiong, Guihong; Li, Meirong; Fang, Shouguo; Islam, Saif Ul; Zhang, Songbai; Li, Fan

2017-09-01

Two double stranded RNAs (dsRNA), likely representing the genome of a novel deltapartitivirus, provisionally named carnation cryptic virus 3 (CCV3), were recovered from Dianthus amurensis. The two dsRNAs were 1,573 (dsRNA1) and 1,561 (dsRNA2) bp in size, each containing a single open reading frame (ORF) encoding a 475- and 411-aa protein, respectively. The 475-aa protein contains a conserved RNA dependent RNA polymerase (RdRp) domain which shows significant homology to RdRps of established or putative partitiviruses, particularly those belonging to the genus Deltapartitivirus. However, it shares an amino acid identity of 75% with its closest relative, the RdRp of the deltapartitivirus beet cryptic virus 2 (BCV2), and is <62% identical to the RdRps of other partitiviruses. In a phylogenetic tree constructed with RdRps of selected partitiviruses, CCV3 clustered with BCV2 and formed a well-supported monophyletic clade with known or putative deltapartitiviruses.

Changing R&D models in research-based pharmaceutical companies.

PubMed

Schuhmacher, Alexander; Gassmann, Oliver; Hinder, Markus

2016-04-27

New drugs serving unmet medical needs are one of the key value drivers of research-based pharmaceutical companies. The efficiency of research and development (R&D), defined as the successful approval and launch of new medicines (output) in the rate of the monetary investments required for R&D (input), has declined since decades. We aimed to identify, analyze and describe the factors that impact the R&D efficiency. Based on publicly available information, we reviewed the R&D models of major research-based pharmaceutical companies and analyzed the key challenges and success factors of a sustainable R&D output. We calculated that the R&D efficiencies of major research-based pharmaceutical companies were in the range of USD 3.2-32.3 billion (2006-2014). As these numbers challenge the model of an innovation-driven pharmaceutical industry, we analyzed the concepts that companies are following to increase their R&D efficiencies: (A) Activities to reduce portfolio and project risk, (B) activities to reduce R&D costs, and (C) activities to increase the innovation potential. While category A comprises measures such as portfolio management and licensing, measures grouped in category B are outsourcing and risk-sharing in late-stage development. Companies made diverse steps to increase their innovation potential and open innovation, exemplified by open source, innovation centers, or crowdsourcing, plays a key role in doing so. In conclusion, research-based pharmaceutical companies need to be aware of the key factors, which impact the rate of innovation, R&D cost and probability of success. Depending on their company strategy and their R&D set-up they can opt for one of the following open innovators: knowledge creator, knowledge integrator or knowledge leverager.

2nd & 3rd Generation Vehicle Subsystems

NASA Technical Reports Server (NTRS)

2000-01-01

This paper contains viewgraph presentation on the "2nd & 3rd Generation Vehicle Subsystems" project. The objective behind this project is to design, develop and test advanced avionics, power systems, power control and distribution components and subsystems for insertion into a highly reliable and low-cost system for a Reusable Launch Vehicles (RLV). The project is divided into two sections: 3rd Generation Vehicle Subsystems and 2nd Generation Vehicle Subsystems. The following topics are discussed under the first section, 3rd Generation Vehicle Subsystems: supporting the NASA RLV program; high-performance guidance & control adaptation for future RLVs; Evolvable Hardware (EHW) for 3rd generation avionics description; Scaleable, Fault-tolerant Intelligent Network or X(trans)ducers (SFINIX); advance electric actuation devices and subsystem technology; hybrid power sources and regeneration technology for electric actuators; and intelligent internal thermal control. Topics discussed in the 2nd Generation Vehicle Subsystems program include: design, development and test of a robust, low-maintenance avionics with no active cooling requirements and autonomous rendezvous and docking systems; design and development of a low maintenance, high reliability, intelligent power systems (fuel cells and battery); and design of a low cost, low maintenance high horsepower actuation systems (actuators).

Improved visual delineation of the intimal flap in Stanford type A and B dissections at 3rd generation dual-source high-pitch CT angiography.

PubMed

Beeres, Martin; Bucher, Andreas M; Wichmann, Julian L; Frellesen, Claudia; Scholtz, Jan E; Albrecht, Moritz; Bodelle, Boris; Nour-Eldin, Nour-Eldin A; Lee, Clara; Kaup, Moritz; Vogl, Thomas J; Gruber-Rouh, Tatjana

2016-07-01

Evaluation of the intimal flap visibility comparing 2nd and 3rd generation dual-source high-pitch CT. Twenty-five consecutive patients with aortic dissection underwent CT angiography on a second and third generation dual-source CT scanner using prospective ECG-gated high-pitch dual-source CT acquisition mode. Contrast material, saline flush and flow rate were kept equal for optimum comparability. The visibility of the intimal flap as well as the delineation of the different vascular structures was evaluated. In 3rd generation dual-source high-pitch CT we could show a significant improvement of intimal flap visibility in aortic dissection. Especially, the far end of the dissection membrane could be better evaluated in 3rd generation high-pitch CT, reaching statistical significance (P < 0.01). 3rd Generation high-pitch CT angiography shows a better delineation of the aortic intimal flap in a small patient cohort, especially in the far ends of the dissection membrane. This might be due to higher tube power in this CT generation. However, to generalise these findings larger trials are needed.

Procedural Learning in Children With Developmental Coordination, Reading, and Attention Disorders.

PubMed

Magallón, Sara; Crespo-Eguílaz, Nerea; Narbona, Juan

2015-10-01

The aim is to assess repetition-based learning of procedures in children with developmental coordination disorder (DCD), reading disorder (RD) and attention-deficit hyperactivity disorder (ADHD). Participants included 187 children, studied in 4 groups: (a) DCD comorbid with RD and ADHD (DCD+RD+ADHD) (n = 30); (b) RD comorbid with ADHD (RD+ADHD) (n = 48); (c) ADHD (n = 19); and typically developing children (control group) (n = 90). Two procedural learning tasks were used: Assembly learning and Mirror drawing. Children were tested on 4 occasions for each task: 3 trials were consecutive and the fourth trial was performed after an interference task. Task performance by DCD+RD+ADHD children improved with training (P < .05); however, the improvement was significantly lower than that achieved by the other groups (RD+ADHD, ADHD and controls) (P < .05). In conclusion, children with DCD+RD+ADHD improve in their use of cognitive-motor procedures over a short training period. Aims of intervention in DCD+RD+ADHD should be based on individual learning abilities. © The Author(s) 2015.

21 CFR 520.1453 - Moxidectin and praziquantel gel.

Code of Federal Regulations, 2011 CFR

2011-04-01

... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.1453 Moxidectin... (2nd and 3rd instars) and G. nasalis (3rd instars); and tapeworms: Anoplocephala perfoliata (adults...

21 CFR 520.1453 - Moxidectin and praziquantel gel.

Code of Federal Regulations, 2014 CFR

2014-04-01

... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.1453 Moxidectin... (2nd and 3rd instars) and G. nasalis (3rd instars); and tapeworms: Anoplocephala perfoliata (adults...

21 CFR 520.1453 - Moxidectin and praziquantel gel.

Code of Federal Regulations, 2012 CFR

2012-04-01

... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.1453 Moxidectin... (2nd and 3rd instars) and G. nasalis (3rd instars); and tapeworms: Anoplocephala perfoliata (adults...

21 CFR 520.1453 - Moxidectin and praziquantel gel.

Code of Federal Regulations, 2013 CFR

2013-04-01

... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.1453 Moxidectin... (2nd and 3rd instars) and G. nasalis (3rd instars); and tapeworms: Anoplocephala perfoliata (adults...

How Rice (Oryza sativa L.) Responds to Elevated As under Different Si-Rich Soil Amendments.

PubMed

Teasley, William A; Limmer, Matthew A; Seyfferth, Angelia L

2017-09-19

Several strategies exist to mitigate As impacts on rice and each has its set of trade-offs with respect to yield, inorganic As content in grain, and CH 4 emissions. The addition of Si to paddy soil can decrease As uptake by rice but how rice will respond to elevated As when soil is amended with Si-rich materials is unresolved. Here, we evaluated yield impacts and grain As content and speciation in rice exposed to elevated As in response to different Si-rich soil amendments including rice husk, rice husk ash, and CaSiO 3 in a pot study. We found that As-induced yield losses were alleviated by Husk amendment, partially alleviated by Ash amendment, and not affected by CaSiO 3 amendment. Furthermore, Husk was the only tested Si-amendment to significantly decrease grain As concentrations. Husk amendment was likely effective at decreasing grain As and improving yield because it provided more plant-available Si, particularly during the reproductive and ripening phases. Both Husk and Ash provided K, which also played a role in yield improvement. This study demonstrates that while Si-rich amendments can affect rice uptake of As, the kinetics of Si dissolution and nutrient availability can also affect As uptake and toxicity in rice.

Interactions between organic amendments and phosphate fertilizers modify phosphate sorption processes in an acid soil

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sckefe, C.R.; Patti, A.F.; Clune, T.S.

2008-07-15

To determine how organic amendments and phosphate fertilizers interact to modify P sorption processes, three phosphate fertilizers were applied to lignite- and compost-amended acid soil and incubated for either 3 or 26 days. The fertilizers applied were potassium dihydrogen phosphate, triple superphosphate, and diammonium phosphate (DAP). After 3 days of incubation, sorption of all three P sources was decreased in the lignite-amended treatments, whereas P sorption was increased in the compost-amended treatments. Increased incubation time (26 days) resulted in significantly decreased P sorption when DAP was added to lignite-amended treatments. Addition of triple superphosphate increased P sorption in lignite- andmore » compost-amended treatments and decreased solution pH compared with DAP application. In addition to the effect of P source, differences in P sorption between the lignite- and compost-amended treatments were driven by differences in solution chemistry, predominantly solution pH and cation dynamics. Soil amendment and fertilizer addition also increased microbial activity in the incubation systems, as measured by carbon dioxide respiration. It is proposed that the combination of lignite and DAP may contribute to decreased P sorption in acid soils, with the positive effects likely caused by both chemical and biological processes, including the formation of soluble organic-metal complexes.« less

Catheter-Based Radiorefrequency Renal Denervation Lowers Blood Pressure in Obese Hypertensive Dogs

PubMed Central

Henegar, Jeffrey R.; Zhang, Yongxing; Rama, Rita De; Hata, Cary; Hall, Michael E.

2014-01-01

BACKGROUND Obesity-induced hypertension appears to be due, in part, to increased renal sympathetic activity. Catheter-based renal denervation (RD) has been reported to lower arterial blood pressure (BP) in humans with resistant hypertension, many of whom are obese. This study was performed to assess the impact of radiofrequency–induced RD on renal function, BP, renal norepinephrine (NE), and histology of nerves along the renal artery in obese, hypertensive dogs, an experimental model that closely mimics cardiorenal and metabolic changes in obese hypertensive humans. METHODS After control measurements of cardiovascular and renal function were obtained in obese dogs fed a high-fat diet, bilateral RD was performed using the St. Jude Medical EnligHTN RD system. After RD, BP was measured continuously for 8 weeks, and glomerular filtration rate (GFR) was measured biweekly for 6 weeks. At the end of the study, renal arteries were collected for histological analysis, and kidneys were obtained for NE measurement. RESULTS Eight weeks after RD, systolic BP fell from 157±5mm Hg pre-RD to 133±3mm Hg (P < 0.01), and mean arterial pressure decreased by 9mm Hg compared with pre-RD (P < 0.01). There were no significant changes in GFR. Renal nerve injury was most prevalent 0.28–3.5mm from the renal artery lumen. RD caused injury in 46% of the renal nerves observed and reduced renal tissue NE by 42% (P < 0.01). CONCLUSIONS Catheter-based RD with the St. Jude Medical EnligHTN system lowers BP in obese dogs without significantly compromising renal function. PMID:24709437

The third/second generation PTH assay ratio as a marker for parathyroid carcinoma: evaluation using an automated platform.

PubMed

Cavalier, Etienne; Betea, Daniela; Schleck, Marie-Louise; Gadisseur, Romy; Vroonen, Laurent; Delanaye, Pierre; Daly, Adrian F; Beckers, Albert

2014-03-01

Parathyroid carcinoma (PCa) is rare and often difficult to differentiate initially from benign disease. Because PCa oversecretes amino PTH that is detected by third-generation but not by second-generation PTH assays, the normal 3rd/2nd generation PTH ratio (<1) is inverted in PCa (ie, >1). The objective of the investigation was to study the utility and advantages of automated 3rd/2nd generation PTH ratio measurements using the Liaison XL platform over existing manual techniques. The study was conducted at a tertiary-referral academic center. This was a retrospective laboratory study. Eleven patients with advanced PCa (mean age 56.0 y). The controls were patients with primary-hyperparathyroidism (n = 144; mean age 53.8 y), renal transplantation (n = 41; mean age 50.6 y), hemodialysis (n = 80; mean age 65.2 y), and healthy elderly subjects (n = 40; mean age 72.6 y). The median (interquartile range) 3rd/2nd generation PTH ratio was 1.16 (1.10-1.38) in the PCa group, which was significantly higher than the control groups: hemodialysis: 0.74 (0.71-0.75); renal transplant: 0.77 (0.73-0.79); primary hyperparathyroidism: 0.76 (0.74-0.78); healthy elderly: 0.80 (0.74-0.83). An inverted 3rd/2nd-generation PTH ratio (>1) was seen in 9 of 11 PCa patients (81.8%) and in 7 of 305 controls (2.3%): 3 of 80 hemodialysis (3.8%), and 4 of 144 primary-hyperparathyroidism patients (2.8%). Of four PCa patients who had a normal PTH ratio with the manual method, two had an inverted 3rd/2nd-generation PTH ratio with the automated method. Study of the 3rd/2nd-generation PTH ratio in large patient populations should be feasible using a mainstream automated platform like the Liaison XL. The current study confirms the utility of the inverted 3rd/2nd-generation PTH ratio as a marker of PCa (sensitivity: 81.8%; specificity: 97.3%).

Oxalate production by wood-rotting fungi growing in toxic metal-amended medium.

PubMed

Jarosz-Wilkolazka, Anna; Gadd, Geoffrey M

2003-07-01

In this report, we have identified oxalic acid as an important metabolite elaborated in the response of wood-rotting fungi to toxic metal stress. The formation of oxalate crystals by white rot fungi (Bjerkandera fumosa, Phlebia radiata and Trametes versicolor) and the brown rot fungus Fomitopsis pinicola, grown on media containing high levels of toxic metal ions has been visualized using scanning electron microscopy (SEM) with energy-dispersive X-ray micro-analysis (EDXA) and HPLC. There were no significant differences between the growth of controls (metal-free) and on the 0.5% CaCO(3), Co(3)(PO(4))(2) or Zn(3)(PO(4))(2)-amended plates. ZnO inhibited the growth of all strains. Crystals were not detected in Zn(3)(PO(4))(2)-amended plates. The four examined strains displayed the formation of crystals on ZnO, Co(3)(PO(4))(2) and CaCO(3)-amended plates.

Arabidopsis RNA Polymerases IV and V Are Required To Establish H3K9 Methylation, but Not Cytosine Methylation, on Geminivirus Chromatin

PubMed Central

Jackel, Jamie N.; Storer, Jessica M.; Coursey, Tami

2016-01-01

ABSTRACT In plants, RNA-directed DNA methylation (RdDM) employs small RNAs to target enzymes that methylate cytosine residues. Cytosine methylation and dimethylation of histone 3 lysine 9 (H3K9me2) are often linked. Together they condition an epigenetic defense that results in chromatin compaction and transcriptional silencing of transposons and viral chromatin. Canonical RdDM (Pol IV-RdDM), involving RNA polymerases IV and V (Pol IV and Pol V), was believed to be necessary to establish cytosine methylation, which in turn could recruit H3K9 methyltransferases. However, recent studies have revealed that a pathway involving Pol II and RNA-dependent RNA polymerase 6 (RDR6) (RDR6-RdDM) is likely responsible for establishing cytosine methylation at naive loci, while Pol IV-RdDM acts to reinforce and maintain it. We used the geminivirus Beet curly top virus (BCTV) as a model to examine the roles of Pol IV and Pol V in establishing repressive viral chromatin methylation. As geminivirus chromatin is formed de novo in infected cells, these viruses are unique models for processes involved in the establishment of epigenetic marks. We confirm that Pol IV and Pol V are not needed to establish viral DNA methylation but are essential for its amplification. Remarkably, however, both Pol IV and Pol V are required for deposition of H3K9me2 on viral chromatin. Our findings suggest that cytosine methylation alone is not sufficient to trigger de novo deposition of H3K9me2 and further that Pol IV-RdDM is responsible for recruiting H3K9 methyltransferases to viral chromatin. IMPORTANCE In plants, RNA-directed DNA methylation (RdDM) uses small RNAs to target cytosine methylation, which is often linked to H3K9me2. These epigenetic marks silence transposable elements and DNA virus genomes, but how they are established is not well understood. Canonical RdDM, involving Pol IV and Pol V, was thought to establish cytosine methylation that in turn could recruit H3K9 methyltransferases, but recent studies compel a reevaluation of this view. We used BCTV to investigate the roles of Pol IV and Pol V in chromatin methylation. We found that both are needed to amplify, but not to establish, DNA methylation. However, both are required for deposition of H3K9me2. Our findings suggest that cytosine methylation is not sufficient to recruit H3K9 methyltransferases to naive viral chromatin and further that Pol IV-RdDM is responsible. PMID:27279611

Arabidopsis RNA Polymerases IV and V Are Required To Establish H3K9 Methylation, but Not Cytosine Methylation, on Geminivirus Chromatin.

PubMed

Jackel, Jamie N; Storer, Jessica M; Coursey, Tami; Bisaro, David M

2016-08-15

In plants, RNA-directed DNA methylation (RdDM) employs small RNAs to target enzymes that methylate cytosine residues. Cytosine methylation and dimethylation of histone 3 lysine 9 (H3K9me2) are often linked. Together they condition an epigenetic defense that results in chromatin compaction and transcriptional silencing of transposons and viral chromatin. Canonical RdDM (Pol IV-RdDM), involving RNA polymerases IV and V (Pol IV and Pol V), was believed to be necessary to establish cytosine methylation, which in turn could recruit H3K9 methyltransferases. However, recent studies have revealed that a pathway involving Pol II and RNA-dependent RNA polymerase 6 (RDR6) (RDR6-RdDM) is likely responsible for establishing cytosine methylation at naive loci, while Pol IV-RdDM acts to reinforce and maintain it. We used the geminivirus Beet curly top virus (BCTV) as a model to examine the roles of Pol IV and Pol V in establishing repressive viral chromatin methylation. As geminivirus chromatin is formed de novo in infected cells, these viruses are unique models for processes involved in the establishment of epigenetic marks. We confirm that Pol IV and Pol V are not needed to establish viral DNA methylation but are essential for its amplification. Remarkably, however, both Pol IV and Pol V are required for deposition of H3K9me2 on viral chromatin. Our findings suggest that cytosine methylation alone is not sufficient to trigger de novo deposition of H3K9me2 and further that Pol IV-RdDM is responsible for recruiting H3K9 methyltransferases to viral chromatin. In plants, RNA-directed DNA methylation (RdDM) uses small RNAs to target cytosine methylation, which is often linked to H3K9me2. These epigenetic marks silence transposable elements and DNA virus genomes, but how they are established is not well understood. Canonical RdDM, involving Pol IV and Pol V, was thought to establish cytosine methylation that in turn could recruit H3K9 methyltransferases, but recent studies compel a reevaluation of this view. We used BCTV to investigate the roles of Pol IV and Pol V in chromatin methylation. We found that both are needed to amplify, but not to establish, DNA methylation. However, both are required for deposition of H3K9me2. Our findings suggest that cytosine methylation is not sufficient to recruit H3K9 methyltransferases to naive viral chromatin and further that Pol IV-RdDM is responsible. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Education for Freedom: Lessons on the First Amendment for Elementary School Students (K-6).

ERIC Educational Resources Information Center

Gallagher, Arlene F.; Singleton, Laurel R.

These lesson plans on the First Amendment are designed to help elementary school students to understand the history and meaning of the First Amendment and its importance in today's society. Seven lessons for primary grades cover the following topics: (1) Forms of expression; (2) Rights in daily life; (3) The First Amendment; (4) The right to meet…

Burnout and psychiatric morbidity among medical students entering clinical training: a three year prospective questionnaire and interview-based study.

PubMed

Dahlin, Marie E; Runeson, Bo

2007-04-12

Mental distress among medical students is often reported. Burnout has not been studied frequently and studies using interviewer-rated diagnoses as outcomes are rarely employed. The objective of this prospective study of medical students was to examine clinically significant psychiatric morbidity and burnout at 3rd year of medical school, considering personality and study conditions measured at 1st year. Questionnaires were sent to 127 first year medical students who were then followed-up at 3rd year of medical school. Eighty-one of 3rd year respondents participated in a diagnostic interview. Personality (HP5-i) and Performance-based self-esteem (PBSE-scale) were assessed at first year, Study conditions (HESI), Burnout (OLBI), Depression (MDI) at 1st and 3rd years. Diagnostic interviews (MINI) were used at 3rd year to assess psychiatric morbidity. High and low burnout at 3rd year was defined by cluster analysis. Logistic regressions were used to identify predictors of high burnout and psychiatric morbidity, controlling for gender. 98 (77%) responded on both occasions, 80 (63%) of these were interviewed. High burnout was predicted by Impulsivity trait, Depressive symptoms at 1st year and Financial concerns at 1st year. When controlling for 3rd year study conditions, Impulsivity and concurrent Workload remained. Of the interviewed sample 21 (27%) had a psychiatric diagnosis, 6 of whom had sought help. Unadjusted analyses showed that psychiatric morbidity was predicted by high Performance-based self-esteem, Disengagement and Depression at 1st year, only the later remained significant in the adjusted analysis. Psychiatric morbidity is common in medical students but few seek help. Burnout has individual as well as environmental explanations and to avoid it, organisational as well as individual interventions may be needed. Early signs of depressive symptoms in medical students may be important to address. Students should be encouraged to seek help and adequate facilities should be available.

Does ligation of internal iliac artery for postpartum hemorrhage affect clitoral artery blood flow and postpartum sexual functions?

PubMed

Kaya, B; Usluogullari, B; Yurttutan, N; Sahan, M H; Güralp, O; Malik, E

2017-12-01

To investigate whether internal iliac artery ligation (IIAL) for postpartum hemorrhage (PPH) affects the sexual life in the postpartum period or significantly reduces the clitoral artery blood flow. The women who underwent IIAL due to PPH during cesarean section (CS) were compared with healthy postpartum women delivered by CS between October 2014 and February 2016 in the Gaziantep Women's Health and Maternity Hospital, Gaziantep, Turkey. Clitoral Doppler flow measurements and the Female Sexual Function Index questionnaire (FSFIQ) were performed in all women in the 3rd and 6th postpartum months. This study was registered at ClinicalTrials.gov with the identification number NCT02409602. Mean age, gravidity and parity, body mass index (BMI), first sexual intercourse after childbirth, and education years were similar in both groups. There was no statistically significant difference in the measurements of RI, PI, PSV, EDV, and S/D between the study and control groups in the 3rd month. Lack of statistical significance was also noted between the study and control groups values in the 6th month, as well as between the 3rd and 6th month's values within both the study group and the control group. Additionally, there were no statistically significant differences in the total FSFI scores including sexual desire, sexual arousal, lubrication, orgasm, sexual satisfaction, and pain domain scores between the study and control groups in the 3rd month; between the study and control groups 6th months; whereas all scores were higher in the 6th month compared to the 3rd month within each group. IIAL does not affect the blood flow of the dorsal clitoral artery between the 3rd and 6th months postpartum and between the women who underwent IIAL due to PPH and healthy postpartum women. The sexual function scores were significantly higher in the 6th month compared to the 3rd month in both groups. Copyright © 2017 Elsevier B.V. All rights reserved.

48 CFR 9903.202-3 - Amendments and revisions.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... 9903.202-3 Section 9903.202-3 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD... ACCOUNTING STANDARDS CONTRACT COVERAGE CAS Program Requirements 9903.202-3 Amendments and revisions..., Disclosure Statements is discouraged except when extensive changes require it to assist the review process. ...

Progression in Running Intensity or Running Volume and the Development of Specific Injuries in Recreational Runners: Run Clever, a Randomized Trial Using Competing Risks.

PubMed

Ramskov, Daniel; Rasmussen, Sten; Sørensen, Henrik; Parner, Erik Thorlund; Lind, Martin; Nielsen, Rasmus

2018-06-12

Study Design Randomized clinical trial, etiology. Background Training intensity and volume have been proposed to be associated with specific running-related injuries. If such an association exists, secondary preventive measures could be initiated by clinicians based on symptoms of a specific injury diagnosis. Objectives To test the following hypotheses: (i) A running schedule focusing on intensity will increase the risk of sustaining Achilles tendinopathy, gastrocnemius injuries and plantar fasciitis compared with hypothesized volume-related injuries. (ii) A running schedule focusing on running volume will increase the risk of sustaining patellofemoral pain syndrome, iliotibial band syndrome and patellar tendinopathy compared with hypothesized intensity-related injuries. Methods Healthy recreational runners were included in a 24-week follow-up, divided into 8-week preconditioning and 16-week specific focus-training. Participants were randomized to one of two running schedules: Schedule Intensity(Sch-I) or Schedule Volume(Sch-V). Sch-I progressed the amount of high intensity running (≥88% VO2max) each week. Sch-V progressed total weekly running volume. Global positioning system watch or smartphone collected data on running. Running-related injuries were diagnosed based on a clinical examination. Estimates were risk difference (RD) and 95%CI. Results Of 447 runners, a total of 80 sustained an injury (Sch-I n=36; Sch-V n=44). Risk of intensity injuries in Sch-I were: RD 2-weeks =-0.8%[-5.0;3.4]; RD 4-weeks =-0.8%[-6.7;5.1]; RD 8-weeks =-2.0%[-9.2;5.1]; RD 16-weeks =-5.1%[-16.5;6.3]. Risk of volume injuries in Sch-V were: RD 2-weeks =-0.9%[-5.0;3.2]; RD 4-weeks =-2.0%[-7.5;3.5]; RD 8-weeks =-3.2%[-9.1;2.7]; RD 16-weeks =-3.4%[-13.2;6.2]. Conclusion No difference in risk of hypothesized intensity and volume specific running-related injuries exist between running schedules focused on progression in either running intensity or volume. Level of Evidence Etiology, level 1b. J Orthop Sports Phys Ther, Epub 12 Jun 2018. doi:10.2519/jospt.2018.8062.

75 FR 12439 - Airworthiness Directives; Thielert Aircraft Engines GmbH (TAE) Models TAE 125-02-99 and TAE 125...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-16

... has amended the Airworthiness Limitation Section (ALS) of the Operation & Maintenance Manual OM-02-02... a new rail pressure control valve P/N 05-7320-E000702 and 02-7320-04100R3 and has amended the ALS of...-7320- 04100R3 and has amended the Airworthiness Limitation Section (ALS) of the Operation & Maintenance...

77 FR 58437 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-20

... Rule Change and Amendments Nos. 1, 2, 3 and 4 Thereto, To Require Members To Provide Customers in TRACE...) of the Securities Exchange Act of 1934 (``Exchange Act'' or ``Act'') \\1\\ and Rule 19b-4 thereunder,\\2... Amendment No. 4 on August 21, 2007. The proposed rule change, as modified by Amendments 1, 2, 3 and 4, was...

1. WEST SIDE AND ENTRY, FROM ACROSS 3RD STREET, LOOKING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. WEST SIDE AND ENTRY, FROM ACROSS 3RD STREET, LOOKING EAST. - Oakland Naval Supply Center, Administration Building-Dental Annex-Dispensary, Between E & F Streets, East of Third Street, Oakland, Alameda County, CA

Department of the Navy Justification of Estimates Amended Fiscal Year 1988 and 1989 Biennial Budget Submitted to Congress February 1988. Operation and Maintenance, Navy. Book 3. Budget Activity 8: Training Medical and OPGA Budget Activity 9: Administration and Assoc Acts. Budget Activity 10: Support to Other Nations Budget Activity 11: Special Operations Forces

DTIC Science & Technology

1988-02-01

8217dCL D~0U :2aw u> Q >0.’a 41 ’ 0 :1:5 - r.4 J0)C.Ř£ to 4 td " C CO to) U) 0 " A. O cw 0 > ;3 w 4 144 w. V).M t 00 J - 4bD £ (d Ŕ 3.0 bcL W 0 .𔃾 0) 03 J...to -4 0 4) 44 41 P-4 Ma to 04 to W 0) M V) W 41 :b% Cý .,q r. ed -m 0 td rd .- a to w to w w to "-4 as 44 r-.4 w 1-4 W w (v to ow ýj M to) C: to CL (1...P -4P0-4 oo W v w ~’L0 . V)4) >%r.0 4w D bo 1-ý40 U G) 0 w w H 0ww 0 w0..4.J. 9 . 40. 𔃺 -1 4 0 WL O.1-w ý400.0 A. ’c-c 0I v’- U w 1 -4U0w ( td (0 L

32 CFR 216.4 - Policy.

Code of Federal Regulations, 2012 CFR

2012-07-01

... notices, etc., on behalf of military recruiters to comply with the Solomon Amendment; (3) Has failed to... comply with the Solomon Amendment; (3) Military recruiters are prohibited from scheduling their visits at...

32 CFR 216.4 - Policy.

Code of Federal Regulations, 2010 CFR

2010-07-01

... notices, etc., on behalf of military recruiters to comply with the Solomon Amendment; (3) Has failed to... comply with the Solomon Amendment; (3) Military recruiters are prohibited from scheduling their visits at...

32 CFR 216.4 - Policy.

Code of Federal Regulations, 2013 CFR

2013-07-01

... notices, etc., on behalf of military recruiters to comply with the Solomon Amendment; (3) Has failed to... comply with the Solomon Amendment; (3) Military recruiters are prohibited from scheduling their visits at...

32 CFR 216.4 - Policy.

Code of Federal Regulations, 2014 CFR

2014-07-01

... notices, etc., on behalf of military recruiters to comply with the Solomon Amendment; (3) Has failed to... comply with the Solomon Amendment; (3) Military recruiters are prohibited from scheduling their visits at...

32 CFR 216.4 - Policy.

Code of Federal Regulations, 2011 CFR

2011-07-01

... notices, etc., on behalf of military recruiters to comply with the Solomon Amendment; (3) Has failed to... comply with the Solomon Amendment; (3) Military recruiters are prohibited from scheduling their visits at...

Epidemiology of 3rd generation cephalosporin-resistant Escherichia coli on dairy farms

USDA-ARS?s Scientific Manuscript database

Dairy cattle have been identified as a reservoir for 3rd generation cephalosporin (3GC)-resistant Escherichia coli. We previously identified 3GC-resistant E. coli from manure composite samples of calves and cows in a survey of 80 farms in Pennsylvania. Resistant strains were most frequently isolated...

Protection from wintertime rainfall reduces nutrient losses and greenhouse gas emissions during the decomposition of poultry and horse manure-based amendments.

PubMed

Maltais-Landry, Gabriel; Neufeld, Katarina; Poon, David; Grant, Nicholas; Nesic, Zoran; Smukler, Sean

2018-04-01

Manure-based soil amendments (herein "amendments") are important fertility sources, but differences among amendment types and management can significantly affect their nutrient value and environmental impacts. A 6-month in situ decomposition experiment was conducted to determine how protection from wintertime rainfall affected nutrient losses and greenhouse gas (GHG) emissions in poultry (broiler chicken and turkey) and horse amendments. Changes in total nutrient concentration were measured every 3 months, changes in ammonium (NH 4 + ) and nitrate (NO 3 - ) concentrations every month, and GHG emissions of carbon dioxide (CO 2 ), methane (CH 4 ), and nitrous oxide (N 2 O) every 7-14 days. Poultry amendments maintained higher nutrient concentrations (except for K), higher emissions of CO 2 and N 2 O, and lower CH 4 emissions than horse amendments. Exposing amendments to rainfall increased total N and NH 4 + losses in poultry amendments, P losses in turkey and horse amendments, and K losses and cumulative N 2 O emissions for all amendments. However, it did not affect CO 2 or CH 4 emissions. Overall, rainfall exposure would decrease total N inputs by 37% (horse), 59% (broiler chicken), or 74% (turkey) for a given application rate (wet weight basis) after 6 months of decomposition, with similar losses for NH 4 + (69-96%), P (41-73%), and K (91-97%). This study confirms the benefits of facilities protected from rainfall to reduce nutrient losses and GHG emissions during amendment decomposition. The impact of rainfall protection on nutrient losses and GHG emissions was monitored during the decomposition of broiler chicken, turkey, and horse manure-based soil amendments. Amendments exposed to rainfall had large ammonium and potassium losses, resulting in a 37-74% decrease in N inputs when compared with amendments protected from rainfall. Nitrous oxide emissions were also higher with rainfall exposure, although it had no effect on carbon dioxide and methane emissions. Overall, this work highlights the benefits of rainfall protection during amendment decomposition to reduce nutrient losses and GHG emissions.

Comparison of 4th-Generation HIV Antigen/Antibody Combination Assay With 3rd-Generation HIV Antibody Assays for the Occurrence of False-Positive and False-Negative Results.

PubMed

Muthukumar, Alagarraju; Alatoom, Adnan; Burns, Susan; Ashmore, Jerry; Kim, Anne; Emerson, Brian; Bannister, Edward; Ansari, M Qasim

2015-01-01

To assess the false-positive and false-negative rates of a 4th-generation human immunodeficiency virus (HIV) assay, the Abbott ARCHITECT, vs 2 HIV 3rd-generation assays, the Siemens Centaur and the Ortho-Clinical Diagnostics Vitros. We examined 123 patient specimens. In the first phase of the study, we compared 99 specimens that had a positive screening result via the 3rd-generation Vitros assay (10 positive, 82 negative, and 7 indeterminate via confirmatory immunofluorescent assay [IFA]/Western blot [WB] testing). In the second phase, we assessed 24 HIV-1 RNA-positive (positive result via the nuclear acid amplification test [NAAT] and negative/indeterminate results via the WB test) specimens harboring acute HIV infection. The 4th-generation ARCHITECT assay yielded fewer false-positive results (n = 2) than the 3rd-generation Centaur (n = 9; P = .02) and Vitros (n = 82; P <.001) assays. One confirmed positive case had a false-negative result via the Centaur assay. When specimens from the 24 patients with acute HIV-1 infection were tested, the ARCHITECT assay yielded fewer false-negative results (n = 5) than the Centaur (n = 10) (P = .13) and the other 3rd-generation tests (n = 16) (P = .002). This study indicates that the 4th-generation ARCHITECT HIV assay yields fewer false-positive and false-negative results than the 3rd-generation HIV assays we tested. Copyright© by the American Society for Clinical Pathology (ASCP).

75 FR 36088 - Appraisal Subcommittee; Rules of Operation; Amendment

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-24

... FEDERAL FINANCIAL INSTITUTIONS EXAMINATION COUNCIL [Docket No. AS10-2] Appraisal Subcommittee; Rules of Operation; Amendment AGENCY: Appraisal Subcommittee of the Federal Financial Institutions... Financial Institutions Examination Council is amending the following sections: Section 3.04 of the Rules of...

Nailfold capillary morphological characteristics of hand-arm vibration syndrome: a cross-sectional study.

PubMed

Chen, QingSong; Chen, GuiPing; Xiao, Bin; Lin, HanSheng; Qu, HongYing; Zhang, DanYing; Shi, MaoGong; Lang, Li; Yang, Bei; Yan, MaoSheng

2016-11-25

The purpose of this study was to investigate the characteristics of nailfold capillaroscopy associated with hand-arm vibration syndrome (HAVS). In total, 113 male gold miners were recruited: 35 workers who were chronically exposed to vibration and developed vibration-induced white finger were defined as the HAVS group, 39 workers who were exposed to vibration but did not have HAVS were classified as the vibration-exposed controls (VEC) group, and 39 workers without vibration exposure were categorised as the non-VEC (NVEC) group. Video capillaroscopy was used to capture images of the 2nd, 3rd and 4th fingers of both hands. The following nailfold capillary characteristics were included: number of capillaries/mm, avascular areas, haemorrhages and enlarged capillaries. The experiments were carried out in the same winter. All characteristics were evaluated under blinded conditions. Significant differences in all morphological characteristics existed between the groups (p<0.05). Avascular areas in the HAVS, VEC and NVEC groups appeared in 74.3%, 43.6% and 25.0% of participants, respectively. A higher percentage of participants had haemorrhages in the HAVS group (65.7%) compared with the other groups (VEC: 7.7% and NVEC: 7.5%). The number of capillaries/mm, input limb width, output limb width, apical width, and ratio of output limb and input limb all had more than 70% sensitivity or specificity of their cut-off value. Nailfold capillary characteristics, especially the number of capillaries/mm, avascular areas, haemorrhages, output limb width, input limb width and apical width alterations, revealed significant associations with HAVS. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

29 CFR 553.3 - Coverage-general.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 3 2011-07-01 2011-07-01 false Coverage-general. 553.3 Section 553.3 Labor Regulations... Coverage—general. (a)(1) In 1966, Congress amended the FLSA to extend coverage to State and local.... (2) In 1972, the Education Amendments further extended coverage to employees of public preschools. (3...

17 CFR 240.13d-2 - Filing of amendments to Schedules 13D or 13G.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) The first electronic amendment to a paper format Schedule 13D (§ 240.13d-101 of this chapter) or... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Filing of amendments to... Under the Securities Exchange Act of 1934 Regulation 13d-G § 240.13d-2 Filing of amendments to Schedules...

77 FR 28864 - Elba Express Company, L.L.C.; Notice of Amendment to Petition To Amend Order Issuing Certificate

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-16

... Company, L.L.C.; Notice of Amendment to Petition To Amend Order Issuing Certificate Take notice that on May 3, 2012, Elba Express Company, L.L.C. (Elba Express), located at 569 Brookwood Village, Suite 501... application may be directed to Pamela R. Donaldson, Principal Regulatory Analyst, Elba Express Company, L.L.C...

Library Services and Construction Act Amendments of 1990. Conference Report (To Accompany H.R. 2742). House of Representatives, 101st Congress, 2nd Session.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC.

This conference report on the Library Services and Construction Act Amendments of 1990 includes the text of a substitute amendment agreed to by a committee of House of Representatives and Senate members. Amendments are presented for the following sections of the act: (1) Short Title; References; (2) Definitions; (3) Authorization of…

Readers select a comprehension mode independent of pronoun: Evidence from fMRI during narrative comprehension.

PubMed

Hartung, Franziska; Hagoort, Peter; Willems, Roel M

2017-07-01

Perspective is a crucial feature for communicating about events. Yet it is unclear how linguistically encoded perspective relates to cognitive perspective taking. Here, we tested the effect of perspective taking with short literary stories. Participants listened to stories with 1st or 3rd person pronouns referring to the protagonist, while undergoing fMRI. When comparing action events with 1st and 3rd person pronouns, we found no evidence for a neural dissociation depending on the pronoun. A split sample approach based on the self-reported experience of perspective taking revealed 3 comprehension preferences. One group showed a strong 1st person preference, another a strong 3rd person preference, while a third group engaged in 1st and 3rd person perspective taking simultaneously. Comparing brain activations of the groups revealed different neural networks. Our results suggest that comprehension is perspective dependent, but not on the perspective suggested by the text, but on the reader's (situational) preference. Copyright © 2017 Elsevier Inc. All rights reserved.

Oligotyping reveals stronger relationship of organic soil bacterial community structure with N-amendments and soil chemistry in comparison to that of mineral soil at Harvard Forest, MA, USA

Treesearch

Swathi A. Turlapati; Rakesh Minocha; Stephanie Long; Jordan Ramsdell; Subhash C. Minocha

2015-01-01

The impact of chronic nitrogen amendments on bacterial communities was evaluated at Harvard Forest, Petersham, MA, USA. Thirty soil samples (3 treatments × 2 soil horizons × 5 subplots) were collected in 2009 from untreated (control), low nitrogen-amended (LN; 50 kg NH4NO3ha-1yr

8 CFR 245.3 - Adjustment of status under section 13 of the Act of September 11, 1957, as amended.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Adjustment of status under section 13 of... RESIDENCE § 245.3 Adjustment of status under section 13 of the Act of September 11, 1957, as amended. Any application for benefits under section 13 of the Act of September 11, 1957, as amended, must be filed on Form...

The pH dependence of the cathodic peak potential of the active sites in bilirubin oxidase.

PubMed

Filip, Jaroslav; Tkac, Jan

2014-04-01

This is the first study showing pH dependence of three distinct redox sites within bilirubin oxidase (BOD) adsorbed on a nanocomposite modified electrode. The 1st redox centre with the highest redox potential Ec(1st)=404 mV vs. Ag/AgCl (614 mV vs. NHE at pH7.0) exhibited pH dependence with a slope -dEc(1st)/dpH=66(±3) mV under a non-turnover process. The 2nd redox centre with a potential Ec(2nd)=228 mV vs. Ag/AgCl (438 mV vs. NHE at pH7.0) was not dependent on pH in the absence and presence of O2. Finally, the 3rd redox site with a redox potential Ec(3rd)=92 mV vs. Ag/AgCl (302 mV vs. NHE at pH7.0) exhibited pH dependence for a cathodic process with -dEc(3rd)/dpH=70(±6) mV and for anodic process with -dEa(3rd)/dpH=73(±2) mV, respectively. Moreover, two break points for dependence of Ec(1st) or Ec(3rd) on pH were observed for the 1st (T1) site and the 3rd site assigned to involvement of two acidic amino acids (Asp105 and Glu463). A diagram of a potential difference between cathodic peaks of BOD as a dependence on pH is shown. The results obtained can be of interest for construction of biofuel cells based on BOD such as for generation of a low level of electricity from body fluids. Copyright © 2013 Elsevier B.V. All rights reserved.

A Family-Based Association Analysis and Meta-Analysis of the Reading Disabilities Candidate Gene DYX1C1

PubMed Central

Tran, C.; Gagnon, F.; Wigg, K.G.; Feng, Y.; Gomez, L.; Cate-Carter, T.D.; Kerr, E.N.; Field, L.L.; Kaplan, B.J.; Lovett, M.W.; Barr, C.L.

2017-01-01

Reading disabilities (RD) have a significant genetic basis and have shown linkage to multiple regions including chromosome 15q. Dyslexia susceptibility 1 candidate gene 1 (DYX1C1) on chromosome 15q21 was originally proposed as a candidate gene with two potentially functional polymorphisms at the −3G/A and 1249G/T positions showing association with RD. However, subsequent studies have yielded mixed results. We performed a literature review and meta-analysis of the −3G/A and 1249G/T polymorphisms, including new unpublished data from two family-based samples. Ten markers in DYX1C1 were genotyped in the two independently ascertained samples. Single marker and −3G/A:1249G/T haplotype analyses were performed for RD in both samples, and quantitative trait analyses using standardized reading-related measures was performed in one of the samples. For the meta-analysis, we used a random-effects model to summarize studies that tested for association between −3G/A or 1249G/T and RD. No significant association was found between the DYX1C1 SNPs and RD or any of the reading-related measures tested after correction for the number of tests performed. The previously reported risk haplotype (−3A:1249T) was not biased in transmission. A total of 9 and 10 study samples were included in the meta-analysis of the −3G/A and 1249G/T polymorphisms, respectively. Neither polymorphism reached statistical significance, but the heterogeneity for the 1249G/T polymorphism was high. The results of this study do not provide evidence for association between the putatively functional SNPs −3G/A and 1249G/T and RD. PMID:23341075

Acute effects of air pollution on respiratory disease mortalities and outpatients in Southeastern China.

PubMed

Mo, Zhe; Fu, Qiuli; Zhang, Lifang; Lyu, Danni; Mao, Guangming; Wu, Lizhi; Xu, Peiwei; Wang, Zhifang; Pan, Xuejiao; Chen, Zhijian; Wang, Xiaofeng; Lou, Xiaoming

2018-02-22

The objective of this study was to investigate the potential association between air pollutants and respiratory diseases (RDs). Generalized additive models were used to analyze the effect of air pollutants on mortalities or outpatient visits. The average concentrations of air pollutants in Hangzhou (HZ) were 1.6-2.8 times higher than those in Zhoushan (ZS), except for O 3 . In a single pollutant model, the increased concentrations of PM 2.5 , NO 2 , and SO 2 were strongly associated with deaths caused by RD in HZ, while PM 2.5 and O 3 were associated with deaths caused by RD in ZS. All air pollutants (PM 2.5 , NO 2 , SO 2 , and O 3 ) were strongly associated with outpatient visits for RD in both HZ and ZS. In multiple pollutant models, a significant association was only observed between PM 2.5 and the mortality rate of RD patients in both HZ and in ZS. Moreover, strong associations between SO 2 , NO 2 , and outpatient visits for RD were observed in HZ and ZS. This study has provided evidence that both the mortality rates and outpatient visits for RD were significantly associated with air pollutants. Furthermore, the results showed that different air pollutant levels lead to regional differences between mortality rates and outpatient visits.

48 CFR 27.201-2 - Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... all R&D solicitations and contracts for which the primary purpose is R&D work, except that this... exclusively for R&D work. (3) Use the clause with its Alternate II in solicitations and contracts for... schedule set by a regulatory body. (b) Insert the clause at 52.227-2, Notice and Assistance Regarding...

Status Report on Medical Materiel Items Tested and Evaluated for Use in the USAF Aeromedical Evacuation System.

DTIC Science & Technology

1986-06-01

P.O. Box 2007 3101 E. Alejo Rd. Palm Springs, CA 92262 Telephone: (619) 327-1571 Date Evaluated June 1979 Summary The BABYbird Ventilator, Model 5900...air. Procurement Manufacturer 15 Product and Manufacturer Infant AIRbird Resuscitator Medical Products Oivision/3M P.O. Box 2007 3101 E. Alejo Rd. Palm...Silicone Bag Medical Products Division/3M P.O. Box 20073101 E. Alejo Rd Palm Springs, CA 92262 Telephone: (619) 327-1571 Date Evaluated July 1978 Sumary

Molecular Interactions of High Energy Fuels and Jet Fuels with Oncogenic Viruses and Endogenous Viruses.

DTIC Science & Technology

1981-10-01

Function of depressed immunologic reactivity during carcinogenesis, 3. Nati. Cancer Inst., 31, 791, 1963. 13. Tarr, M.3., Olsen, R.G., Hoover, E.A...cell line, RDII4/RD. This cell line was obtained from the biological carcinogenesis program of Frederick Cancer Research Center. After discussion with...Sandra West of the Frederick Cancer Research Center, a procedure was developed and is now routinely used to produce and isolate the RD14 virus. The RD14

5. WEST SIDE, FROM ACROSS 3RD STREET, LOOKING EAST, WITH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. WEST SIDE, FROM ACROSS 3RD STREET, LOOKING EAST, WITH NAVY EXCHANGE RETAIL SERVICE AT TOP OF STAIRS. - Oakland Naval Supply Center, Administration Building-Cafeteria, East of Third Street between D & E Streets, Oakland, Alameda County, CA

Maternal hemodynamics, fetal biometry and Dopplers in pregnancies followed up for suspected fetal growth restriction.

PubMed

Roberts, Llinos A; Ling, Hua Zen; Poon, Liona; Nicolaides, Kypros H; Kametas, Nikos A

2018-04-01

To assess whether in a cohort of patients with small for gestational age (SGA) foetuses with estimated fetal weight ≤10 th percentile, maternal hemodynamics, fetal biometry and Dopplers at presentation, can predict the subsequent development of abnormal fetal Dopplers or delivery with birthweight <3 rd percentile. The study population comprised of 86 singleton pregnancies with SGA fetuses presenting at a median gestational age of 32 (range 26-35) weeks. We measured maternal cardiac function with a non-invasive transthoracic bioreactance monitor (NICOM, Cheetah), mean arterial pressure, fetal biometry, umbilical artery (UA), middle cerebral artery (MCA) and uterine artery (UT) pulsatility index (PI) and the deepest vertical pool (DVP) of amniotic fluid. Z-scores of these variables were calculated based on reported reference ranges and the values were compared between those with evidence of abnormal fetal Dopplers at presentation (group 1), those that developed abnormal Dopplers in subsequent visits (group 2) and those who did not develop abnormal Dopplers throughout pregnancy (group 3). Abnormal fetal Dopplers were defined as UAPI >95 th percentile, or MCA PI <5 th percentile. Differences in measured variables at presentation were also compared between pregnancies delivering a baby with birthweight <3 rd and ≥3 rd percentile. Multivariate logistic regression analysis was used to determine significant predictors of birthweight <3 rd percentile and evolution from normal fetal Dopplers to abnormal fetal Dopplers in groups 2 and 3. In the study population 14 (16%) cases were in group 1, 19 (22%) in group 2 and 53 (62%) in group 3. The birthweight was <3 rd percentile in 39 (45%) cases and ≥3 rd percentile in 47 (55%). In the study groups, compared to normal populations, there was decreased cardiac output and stroke volume and increased peripheral vascular resistance and mean arterial pressure (MAP) and the deviations from normal were most marked in group 1. Pregnancies with a birthweight <3 rd , compared to those ≥3 rd percentile, had higher deviations from normal in fetal biometry, maternal cardiac output, stroke volume, heart rate and peripheral vascular resistance and UT-PI. Multivariate logistic regression analysis demonstrated that in the prediction of birth weight ≤3 rd percentile, maternal hemodynamics provided significant improvement to the prediction provided by maternal demographics, fetal biometry and UT-PI, UA-PI and MCA-PI (difference between AUCs 0.18, 95% CI 0.06-0.29, p=0.002). In contrast, there was no significant independent contribution from maternal hemodynamics in the prediction of subsequent abnormal fetal Dopplers. In pregnancies with SGA fetuses there is decreased maternal cardiac output and stroke volume and increased peripheral vascular resistance and MAP and the deviations from normal are most marked in cases of redistribution in the fetal circulation and reduced amniotic fluid volume. This article is protected by copyright. All rights reserved.

78 FR 48724 - Virgil C. Summer Nuclear Station, Units 2 and 3; South Carolina Electric and Gas; Change to the...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-09

...The U.S. Nuclear Regulatory Commission (NRC) is granting an exemption to allow a departure from the certification information of Tier 1 of the generic design control document (DCD) and issuing License Amendment No. 7 to Combined Licenses (COL), NPF-93 and NPF-94. The COLs were issued to South Carolina Electric and Gas (SCE&G) and South Carolina Public Service Authority (Santee Cooper) (the licensee), for construction and operation of the Virgil C. Summer Nuclear Station (VCSNS), Units 2 and 3 located in Fairfield County, South Carolina. The amendment changes requested revise the design of the bracing used to support the Turbine Building structure. This request requires changing Tier 1 information found in the Design Description portion of Updated Final Safety Analysis Report (UFSAR) section 3.3, ``Buildings.'' The granting of the exemption allows the changes to Tier 1 information asked for in the amendment. Because the acceptability of the exemption was determined in part by the acceptability of the amendment, the exemption and amendment are being issued concurrently.

78 FR 45990 - Vogtle Electric Generating Station, Units 3 and 4; Southern Nuclear Operating Company; Change to...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-30

...The U.S. Nuclear Regulatory Commission (NRC) is granting both an exemption to allow a departure from the certification information of Tier 1 of the generic design control document (DCD) and is issuing License Amendment No. 8 to Combined Licenses (COL), NPF-91 and NPF-92. The COLs were issued to Southern Nuclear Operating Company, Inc., and Georgia Power Company, Oglethorpe Power Corporation, Municipal Electric Authority of Georgia, and the City of Dalton, Georgia (the licensee); for construction and operation of the Vogtle Electric Generating Plant (VEGP), Units 3 and 4, located in Burke County, Georgia. The amendment requests to revise the design of the bracing used to support the Turbine Building structure. This request requires changing Tier 1 information found in the Design Description portion of Updated Final Safety Analysis Report (UFSAR) Section 3.3, ``Buildings.'' The granting of the exemption allows the changes to Tier 1 information asked for in the amendment. Because the acceptability of the exemption was determined in part by the acceptability of the amendment, the exemption and amendment are being issued concurrently.

48 CFR 30.202-3 - Amendments and revisions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Amendments and revisions. 30.202-3 Section 30.202-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 30.202...

Identification of a Pyridoxine-Derived Small-Molecule Inhibitor Targeting Dengue Virus RNA-Dependent RNA Polymerase.

PubMed

Xu, Hong-Tao; Colby-Germinario, Susan P; Hassounah, Said; Quashie, Peter K; Han, Yingshan; Oliveira, Maureen; Stranix, Brent R; Wainberg, Mark A

2016-01-01

The viral RNA-dependent RNA polymerase (RdRp) activity of the dengue virus (DENV) NS5 protein is an attractive target for drug design. Here, we report the identification of a novel class of inhibitor (i.e., an active-site metal ion chelator) that acts against DENV RdRp activity. DENV RdRp utilizes a two-metal-ion mechanism of catalysis; therefore, we constructed a small library of compounds, through mechanism-based drug design, aimed at chelating divalent metal ions in the catalytic site of DENV RdRp. We now describe a pyridoxine-derived small-molecule inhibitor that targets DENV RdRp and show that 5-benzenesulfonylmethyl-3-hydroxy-4-hydroxymethyl-pyridine-2-carboxylic acid hydroxyamide (termed DMB220) inhibited the RdRp activity of DENV serotypes 1 to 4 at low micromolar 50% inhibitory concentrations (IC50s of 5 to 6.7 μM) in an enzymatic assay. The antiviral activity of DMB220 against DENV infection was also verified in a cell-based assay and showed a 50% effective concentration (EC50) of <3 μM. Enzyme assays proved that DMB220 was competitive with nucleotide incorporation. DMB220 did not inhibit the enzymatic activity of recombinant HIV-1 reverse transcriptase and showed only weak inhibition of HIV-1 integrase strand transfer activity, indicating high specificity for DENV RdRp. S600T substitution in the DENV RdRp, which was previously shown to confer resistance to nucleoside analogue inhibitors (NI), conferred 3-fold hypersusceptibility to DMB220, and enzymatic analyses showed that this hypersusceptibility may arise from the decreased binding/incorporation efficiency of the natural NTP substrate without significantly impacting inhibitor binding. Thus, metal ion chelation at the active site of DENV RdRp represents a viable anti-DENV strategy, and DMB220 is the first of a new class of DENV inhibitor. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Safety and efficacy of intravitreal injection of recombinant erythropoietin for protection of photoreceptor cells in a rat model of retinal detachment

PubMed Central

Xie, Z; Chen, F; Wu, X; Zhuang, C; Zhu, J; Wang, J; Ji, H; Wang, Y; Hua, X

2012-01-01

Purpose To elucidate the safety and efficacy of exogenous erythropoietin (EPO) for the protection of photoreceptor cells in a rat model of retinal detachment (RD). Methods Recombinant rat EPO (400 ng) was injected into the vitreous cavity of normal rats to observe the eye manifestations. Retinal function was assessed by flash electroretinograms. Histopathological examination of retinal tissue was performed at 14 days and 2 months after injection, respectively. To investigate the inhibitory effect of EPO on photoreceptor cell apoptosis in RD rats, 100, 200, or 400 ng EPO was injected into the vitreous cavity immediately after RD model establishment. Apoptosis of photoreceptor cells was determined at 3 days after injection. Caspase-3 activation was measured by western blot analysis and immunofluorescence, respectively, and the level of Bcl-XL expression was analyzed by western blot. Results Intravitreal injection of EPO 400 ng into normal rats had no significant impact on retinal function, morphology, or structure. Apoptosis of retinal photoreceptor cells apparently increased after RD and was significantly reduced following EPO treatment. The thickness of the outer nuclear layer in the RD+400 ng group was significantly thicker than that in other experimental RD groups both at 14 days and at 2 months after RD (P<0.05). Western blot and immunofluorescence analyses showed decreased caspase-3 activation and increased Bcl-XL expression following EPO treatment. Conclusion Intravitreal injection of EPO 400 ng is safe, and EPO may suppress caspase-3 activation and enhance Bcl-XL expression, resulting in inhibition of apoptosis and protection of photoreceptor cells. PMID:22020175

15 CFR Supplement No. 3 to Part 715 - Deadlines for Submission of Declarations, No Changes Authorization Forms, Amendments for...

Code of Federal Regulations, 2013 CFR

2013-01-01

... Declarations, No Changes Authorization Forms, Amendments for Unscheduled Discrete Organic Chemical (UDOC... COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING UNSCHEDULED DISCRETE ORGANIC..., No Changes Authorization Forms, Amendments for Unscheduled Discrete Organic Chemical (UDOC...

15 CFR Supplement No. 3 to Part 715 - Deadlines for Submission of Declarations, No Changes Authorization Forms, Amendments for...

Code of Federal Regulations, 2011 CFR

2011-01-01

... Declarations, No Changes Authorization Forms, Amendments for Unscheduled Discrete Organic Chemical (UDOC... COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING UNSCHEDULED DISCRETE ORGANIC... Changes Authorization Forms, Amendments for Unscheduled Discrete Organic Chemical (UDOC) Facilities, and...

15 CFR Supplement No. 3 to Part 715 - Deadlines for Submission of Declarations, No Changes Authorization Forms, Amendments for...

Code of Federal Regulations, 2014 CFR

2014-01-01

... Declarations, No Changes Authorization Forms, Amendments for Unscheduled Discrete Organic Chemical (UDOC... COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING UNSCHEDULED DISCRETE ORGANIC..., No Changes Authorization Forms, Amendments for Unscheduled Discrete Organic Chemical (UDOC...

15 CFR Supplement No. 3 to Part 715 - Deadlines for Submission of Declarations, No Changes Authorization Forms, Amendments for...

Code of Federal Regulations, 2012 CFR

2012-01-01

... Declarations, No Changes Authorization Forms, Amendments for Unscheduled Discrete Organic Chemical (UDOC... COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING UNSCHEDULED DISCRETE ORGANIC... Changes Authorization Forms, Amendments for Unscheduled Discrete Organic Chemical (UDOC) Facilities, and...

15 CFR Supplement No. 3 to Part 715 - Deadlines for Submission of Declarations, No Changes Authorization Forms, Amendments for...

Code of Federal Regulations, 2010 CFR

2010-01-01

... Declarations, No Changes Authorization Forms, Amendments for Unscheduled Discrete Organic Chemical (UDOC... COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING UNSCHEDULED DISCRETE ORGANIC... Changes Authorization Forms, Amendments for Unscheduled Discrete Organic Chemical (UDOC) Facilities, and...

14 CFR 133.25 - Amendment of certificate.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Amendment of certificate. 133.25 Section 133.25 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED...-LOAD OPERATIONS Certification Rules § 133.25 Amendment of certificate. (a) The holder of a Rotorcraft...

14 CFR 139.205 - Amendment of Airport Certification Manual.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) Under § 139.3, the Regional Airports Division Manager may amend any Airport Certification Manual... Airports Division Manager's own initiative, if the Regional Airports Division Manager determines that... proposed amendment to its Airport Certification Manual to the Regional Airports Division Manager at least...

29 CFR 1905.3 - Petitions for amendments to this part.

Code of Federal Regulations, 2010 CFR

2010-07-01

... UNDER THE WILLIAMS-STEIGER OCCUPATIONAL SAFETY AND HEALTH ACT OF 1970 General § 1905.3 Petitions for... 29 Labor 5 2010-07-01 2010-07-01 false Petitions for amendments to this part. 1905.3 Section 1905.3 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION...

Differential Modulation of Retinal Degeneration by Ccl2 and Cx3cr1 Chemokine Signalling

PubMed Central

Luhmann, Ulrich F. O.; Lange, Clemens A.; Robbie, Scott; Munro, Peter M. G.; Cowing, Jill A.; Armer, Hannah E. J.; Luong, Vy; Carvalho, Livia S.; MacLaren, Robert E.; Fitzke, Frederick W.; Bainbridge, James W. B.; Ali, Robin R.

2012-01-01

Microglia and macrophages are recruited to sites of retinal degeneration where local cytokines and chemokines determine protective or neurotoxic microglia responses. Defining the role of Ccl2-Ccr2 and Cx3cl1-Cx3cr1 signalling for retinal pathology is of particular interest because of its potential role in age-related macular degeneration (AMD). Ccl2, Ccr2, and Cx3cr1 signalling defects impair macrophage trafficking, but have, in several conflicting studies, been reported to show different degrees of age-related retinal degeneration. Ccl2/Cx3cr1 double knockout (CCDKO) mice show an early onset retinal degeneration and have been suggested as a model for AMD. In order to understand phenotypic discrepancies in different chemokine knockout lines and to study how defects in Ccl2 and/or Cx3cr1 signalling contribute to the described early onset retinal degeneration, we defined primary and secondary pathological events in CCDKO mice. To control for genetic background variability, we compared the original phenotype with that of single Ccl2, Cx3cr1 and Ccl2/Cx3cr1 double knockout mice obtained from backcrosses of CCDKO with C57Bl/6 mice. We found that the primary pathological event in CCDKO mice develops in the inferior outer nuclear layer independently of light around postnatal day P14. RPE and vascular lesions develop secondarily with increasing penetrance with age and are clinically similar to retinal telangiectasia not to choroidal neovascularisation. Furthermore, we provide evidence that a third autosomal recessive gene causes the degeneration in CCDKO mice and in all affected re-derived lines and subsequently demonstrated co-segregation of the naturally occurring RD8 mutation in the Crb1 gene. By comparing CCDKO mice with re-derived CCl2−/−/Crb1Rd8/RD8, Cx3cr1−/−/Crb1Rd8/RD8 and CCl2−/−/Cx3cr1−/−/Crb1Rd8/RD8 mice, we observed a differential modulation of the retinal phenotype by genetic background and both chemokine signalling pathways. These findings indicate that CCDKO mice are not a model of AMD, but a model for an inherited retinal degeneration that is differentially modulated by Ccl2-Ccr2 and Cx3cl1-Cx3cr1 chemokine signalling. PMID:22545116

One stop or full stop? The continuing challenges for researchers despite the new streamlined NHS research governance process.

PubMed

Thompson, Andrew G H; France, Emma F

2010-05-13

Obtaining the necessary approvals and permission for clinical research requires successful negotiation of the ethical and R&D layers of the NHS. Differences in structure and governance frameworks feature between the constituent nations of the UK (England, Scotland, Wales and Northern Ireland), which adds complexity to cross-national studies. Difficulties in carrying out research in the NHS in the UK due to bureaucratic and time-consuming governance processes have led to the development of a new system of application and co-ordination from 2009. This paper illustrates how this new system fails to be consistent and streamlined and is unlikely to become so unless changes are made to the implementation and management of the governance processes. We present a case study of the research governance process at the survey stage of an investigation into the use, preferences and need for information by people making choices or decisions about health care. The method involved home-based, face-to-face interviewing in a questionnaire survey in relation to decisions about lymphoma treatment, Down's syndrome screening in pregnancy, and caring for people with dementia. Our experience of the ethics stage was very positive, noting an efficient process of application and a speedy decision, both in relation to the initial application and to subsequent substantial amendments. By contrast, the R&D stages were very slow, most with unexplained delays, but some offering contradictory advice and exhibiting a lack of clear guidance and training for NHS staff. The R&D arrangements in Scotland were far quicker and more likely to be successful than in England. Overall, the delays were so severe that substantial parts of the research could not be delivered as planned within the funding timescale. If high-quality research in the NHS, particularly in England, is to be delivered in a timely and cost-effective way, R&D processes for gaining research governance approval need improvement. Attention is needed in process implementation and management, particularly in relation to staff training, as well as clarity in guidance and communication within and between organisations.

One stop or full stop? The continuing challenges for researchers despite the new streamlined NHS research governance process

PubMed Central

2010-01-01

Background Obtaining the necessary approvals and permission for clinical research requires successful negotiation of the ethical and R&D layers of the NHS. Differences in structure and governance frameworks feature between the constituent nations of the UK (England, Scotland, Wales and Northern Ireland), which adds complexity to cross-national studies. Difficulties in carrying out research in the NHS in the UK due to bureaucratic and time-consuming governance processes have led to the development of a new system of application and co-ordination from 2009. This paper illustrates how this new system fails to be consistent and streamlined and is unlikely to become so unless changes are made to the implementation and management of the governance processes. Methods We present a case study of the research governance process at the survey stage of an investigation into the use, preferences and need for information by people making choices or decisions about health care. The method involved home-based, face-to-face interviewing in a questionnaire survey in relation to decisions about lymphoma treatment, Down's syndrome screening in pregnancy, and caring for people with dementia. Results Our experience of the ethics stage was very positive, noting an efficient process of application and a speedy decision, both in relation to the initial application and to subsequent substantial amendments. By contrast, the R&D stages were very slow, most with unexplained delays, but some offering contradictory advice and exhibiting a lack of clear guidance and training for NHS staff. The R&D arrangements in Scotland were far quicker and more likely to be successful than in England. Overall, the delays were so severe that substantial parts of the research could not be delivered as planned within the funding timescale. Conclusions If high-quality research in the NHS, particularly in England, is to be delivered in a timely and cost-effective way, R&D processes for gaining research governance approval need improvement. Attention is needed in process implementation and management, particularly in relation to staff training, as well as clarity in guidance and communication within and between organisations. PMID:20465819

Alum amendment effects on phosphorus release and distribution in poultry litter-amended sandy soils

USGS Publications Warehouse

Staats, K.E.; Arai, Y.; Sparks, D.L.

2004-01-01

Increased poultry production has contributed to excess nutrient problems in Atlantic Coastal Plain soils due to land application of poultry litter (PL). Aluminum sulfate [alum, Al2(SO4)3?? 14H2O] amendment of PL effectively reduces soluble phosphorus (P) in the PL; however, the effects of these litters when added to acidic, sandy soils are not well understood. The objective of this study was to investigate the efficacy of alum-amended poultry litter in reducing P release from three Delaware Coastal Plain soils: Evesboro loamy sand (Ev; excessively drained, mesic, coated Typic Quartzipsamments), Rumford loamy sand (Ru; well drained, coarse-loamy, siliceous, subactive, thermic Typic Hapludults), and Pocomoke sandy loam (Pm; very poorly drained, coarse-loamy, siliceous, active, thermic Typic Umbraquults). Long-term (25 d) and short-term (24 h) desorption studies were conducted, in addition to chemical extractions and kinetic modeling, to observe the changes that alum-amended versus unamended PL caused in the soils. The Ev, Ru, and Pm soils were incubated with 9 Mg ha-1 of alum-amended or unamended PL. Long-term desorption (25 d) of the incubated material resulted in approximately 13.5% (Ev), 12.7% (Ru), and 13.3% (Pm) reductions in cumulative P desorbed when comparing soil treated with unamended and alum-amended PL. In addition, the P release from the soil treated with alum-amended litter was not significantly different from the control (soil alone). Short-term desorption (24 h) showed 7.3% (Ev), 15.4% (Ru), and 20% (Pm) reductions. The overall implication from this study is that the use of alum as a PL amendment is useful in coarse-textured soils of the Coastal Plain. With increased application of alum-amended PL, more significant decreases may be possible with little or no effect on soil quality.

Pediatric dentistry clinical education venues evaluation by pre and post-doctoral students.

PubMed

Bimstein, E; Mayes, A; Mittal, Hc

2014-01-01

To evaluate dental students' perspectives about pre- and post-doctoral pediatric dentistry education venues. Surveys with visual analog scales (from 0 to 100) measuring the educational contribution of pediatric dentistry venues were conducted. The pre-doctoral venues included a 3rd year university twilight clinic (UTC), a 3rd year urban community based clinic (CBC) and 4th year mobile clinics (MCs). The post-doctoral venues included treatment of children under general anesthesia, oral sedations, a regular clinic (no sedations), seminars, journal club, case conferences and studding for the American Board of Pediatric Dentistry. Analyses of variance between the scores indicated that the 3rd year CBC score (68.2 ± 4.5) was statistically significant higher (p= .007) than the one for the 3rd year UTC score (44.9 ± 6.1). The 4th year students' MCs score (61.4 ± 4.0) was statistically significant higher than their retrospective scores for the 3rd year CBC (56.4 ± 4.4) or UTC (42.2 ± 4.9) scores (p= .03 and .004 respectively). Among the didactic or clinical post-doctoral venues, the regular clinic and the seminars received the highest scores (84.3 ± 1.7 and 71.6 ± 2.8 respectively). pre-doctoral community-based clinical education and post-doctoral regular university based clinic are considered by students to provide the main contribution to pediatric dental education.

Influence of training in the use and generation of evidence on episiotomy practice and perineal trauma

PubMed Central

Ho, Jacqueline J.; Pattanittum, Porjai; Japaraj, Robert P.; Turner, Tari; Swadpanich, Ussanee; Crowther, Caroline A.

2010-01-01

Objective To examine episiotomy practices before and after a multi-component intervention designed to support the use and generation of research evidence in maternal and neonatal health care. Methods Set in 9 centers across 4 Southeast Asian countries, a retrospective survey was performed for 12 recommended pregnancy/childbirth practices and 13 outcomes of women in each center before and after intervention. Qualitative interviews were conducted to assess staff awareness and experience in evidence-based practice. Results There were significant decreases in the rate of episiotomy, from 64.1% to 60.1% (risk difference [RD] –4.0; 95% confidence interval [CI], –5.8 to –2.2) for all women and from 92.2% to 80.7% (RD –11.5; 95% CI, –13.4 to –9.6) for nulliparous women. Severe trauma decreased from 3.9% to 1.9% (RD –2.0; 95% CI, –2.7 to –1.4) for all women and from 6.7% to 3.0% (RD –3.7; 95% CI, –4.9 to –2.5) for nulliparous women. The frequency of intact perineum increased from 12.4% to 15.6% (RD 3.2; 95% CI, 1.9–4.6) for all women and from 1.7% to 8.0% (RD 6.3; 95% CI, 5.0–7.5) for nulliparous women. Conclusion An intervention based on understanding and using the best available evidence can result in significant improvements in care and health outcomes. PMID:20598690

Availability and range of tobacco products for sale in Massachusetts pharmacies.

PubMed

Seidenberg, Andrew B; Hong, Weiwei; Liu, Jiayue; Noel, Jonathan K; Rees, Vaughan W

2013-11-01

New tobacco control policies have been introduced in Massachusetts which restrict tobacco product sales in pharmacies. The purpose of this investigation was to outline the scope of pharmacy involvement in the tobacco market by assessing the availability and range of tobacco products sold in Massachusetts pharmacies. Public listings of licenced pharmacies and tobacco retailers in Massachusetts were examined to determine the proportion of pharmacies licenced to sell tobacco, and the proportion of tobacco retailers possessing a pharmacy licence. Telephone interviews were conducted with a random sample (n=70) of pharmacies possessing a tobacco licence to assess the availability and range of tobacco products for sale. The availability of nicotine replacement therapy (NRT) products was assessed as a comparison. The majority of pharmacies in Massachusetts possessed a tobacco licence (69%), and pharmacies made up 9% of licenced tobacco retailers. Among pharmacies surveyed that reported selling tobacco (90%), cigarettes were the most available tobacco product for sale (100%), followed by cigars (69%), little cigars/cigarillos (66%), moist snuff (53%), pipe tobacco (49%), roll-your-own tobacco (34%), snus (14%), dissolvable tobacco (11%) and electronic cigarettes (2%). Nearly all pharmacies selling tobacco offered the nicotine patch (100%), gum (100%) and lozenge (98%). Tobacco-free pharmacy policies would affect a majority of Massachusetts pharmacies and remove a variety of tobacco products from their store shelves. Further, nearly one in ten tobacco retailers would be eliminated by prohibiting tobacco sales in Massachusetts pharmacies statewide.

Liquor licences issued to Australian schools.

PubMed

Ward, Bernadette M; Kippen, Rebecca; Munro, Geoffrey; Buykx, Penny; McBride, Nyanda; Wiggers, John; Clark, Madeline

2017-08-01

Children's positive socialisation to alcohol is associated with early initiation of drinking and alcohol-related harm in adult life. Internationally, there have been reports of adults' alcohol consumption at school events in the presence of children. The aim of this research was to identify the conditions under which Australian schools are required to apply for a liquor licence and the associated prevalence of liquor licences for these events where children were likely to be present. A document review was conducted to examine temporary liquor licensing legislation. Quantitative analysis was used to examine relevant licensing data. Coding criteria was developed to determine school type, student year levels and the likely presence of children. Four jurisdictions provided data on 1817 relevant licences. The average annual licences/100 schools was highest amongst Independent schools followed by Catholic and public (government) schools. The rates were highest in Queensland and Victoria where children were present at 61% and 32% of events respectively. While there are legislative differences across jurisdictions, the prevalence of adults' alcohol use at school events in the presence of children may reflect the various education department policies and principals' and school communities' beliefs and attitudes. Licences are not required for all events where liquor is consumed so the prevalence of adults' use of alcohol at school events is likely to be higher than our analyses imply. Such practices may undermine teaching about alcohol use in the school curriculum and health promotion efforts to develop alcohol-free events when children are present.

Inhibitory Effects and Sympathetic Mechanisms of Distension in the Distal Organs on Small Bowel Motility and Slow Waves in Canine.

PubMed

Song, Jun; Yin, Jieyun; Chen, Jiande D Z

2015-12-01

Rectal distension (RD) is known to induce intestinal dysmotility. Few studies were performed to compare effects of RD, colon distension (CD) and duodenal distension (DD) on small bowel motility. This study aimed to investigate effects and underlying mechanisms of distensions in these regions on intestinal motility and slow waves. Eight dogs chronically implanted with a duodenal fistula, a proximal colon fistula, and intestinal serosal electrodes were studied in six sessions: control, RD, CD, DD, RD + guanethidine, and CD + guanethidine. Postprandial intestinal contractions and slow waves were recorded for the assessment of intestinal motility. The electrocardiogram was recorded for the assessment of autonomic functions. (1) Isobaric RD and CD suppressed intestinal contractions (contractile index: 6.0 ± 0.4 with RD vs. 9.9 ± 0.9 at baseline, P = 0.001, 5.3 ± 0.2 with CD vs. 7.7 ± 0.8 at baseline, P = 0.008). Guanethidine at 3 mg/kg iv was able to partially block the effects. (2) RD and CD reduced the percentage of normal intestinal slow waves from 92.1 ± 2.8 to 64.2 ± 3.4 % (P < 0.001) and from 90 ± 2.7 to 69.2 ± 3.7 % (P = 0.01), respectively. Guanethidine could eliminate these inhibitory effects. (3) DD did not induce any changes in small intestinal contractions and slow waves (P > 0.05). (4) The spectral analysis of the heart rate variability showed that both RD and CD increased sympathetic activity (LF) and reduced vagal activity (HF) (P < 0.05). Isobaric RD and CD could inhibit postprandial intestinal motility and impair intestinal slow waves, which were mediated via the sympathetic pathway. However, DD at a site proximal to the measurement site did not seem to impair small intestinal contractions or slow waves.

Short-term effects of sugarcane waste products from ethanol production plant as soil amendments on sugarcane growth and metal stabilization.

PubMed

Akkajit, Pensiri; DeSutter, Thomas; Tongcumpou, Chantra

2013-05-01

Numerous waste products have been widely studied and used as soil amendments and metal immobilizing agents. Waste utilization from ethanol production processes as soil amendments is one of the most promising and sustainable options to help utilize materials effectively, reduce waste disposal, and add value to byproducts. As a consequence, this present work carried out a four-month pot experiment of sugarcane (Saccharum officinarum L.) cultivation in Cd and Zn contaminated soil to determine the effect of three sugarcane waste products (boiler ash, filter cake and vinasse) as soil amendment on sugarcane growth, metal translocation and accumulation in sugarcane, and fractionation of Cd and Zn in soil by the BCR sequential extraction. Four treatments were tested: (1) non-amended soil; (2) 3% w/w boiler ash; (3) 3% w/w filter cake; and (4) a combination of 1.5% boiler ash and 1.5% vinasse (w/w). Our findings showed the improved biomass production of sugarcanes; 6 and 3-fold higher for the above ground parts (from 8.5 to 57.6 g per plant) and root (from 2.1 to 6.59 g per plant), respectively, as compared to non-amended soil. Although there was no significant difference in Cd and Zn uptake in sugarcane (mg kg(-1)) between the non-amended soil and the treated soils (0.44 to 0.52 mg Cd kg(-1) and 39.9 to 48.1 mg Zn kg(-1), respectively), the reduction of the most bioavailable Cd concentration (BCR1 + 2) in the treated soils (35.4-54.5%) and the transformation of metal into an insoluble fraction (BCR3) highlighted the beneficial effects of sugarcane waste-products in promoting the sugarcane growth and Cd stabilization in soil.

75 FR 50884 - Navigation and Navigable Waters; Technical, Organizational, and Conforming Amendments, Sector...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-18

... 3 and 165 to reflect changes in Coast Guard internal organizational structure. Sector Portland and... 1625-ZA25 Navigation and Navigable Waters; Technical, Organizational, and Conforming Amendments, Sector... Waters; Technical, Organizational, and Conforming Amendments, Sector Columbia River.'' 2. On page 48564...

31 CFR 598.401 - Reference to amended sections.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Reference to amended sections. 598.401 Section 598.401 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued... REGULATIONS Interpretations § 598.401 Reference to amended sections. Except as otherwise specified, reference...

78 FR 48298 - Amendment of Class E Airspace; Commerce, TX

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-08

...-0269; Airspace Docket No. 13-ASW-3] Amendment of Class E Airspace; Commerce, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E airspace at Commerce, TX. Additional controlled airspace is necessary to accommodate new Area Navigation (RNAV...

76 FR 21828 - Proposed Amendment of Class E Airspace; Mobridge, SD

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-19

...-0134; Airspace Docket No. 11-AGL-3] Proposed Amendment of Class E Airspace; Mobridge, SD AGENCY... action proposes to amend Class E airspace at Mobridge, SD. Additional controlled airspace is necessary to... accommodate new standard instrument approach procedures at Mobridge Municipal Airport, Mobridge, SD...

76 FR 44257 - Amendment of Class E Airspace; Mobridge, SD

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-25

...-0134; Airspace Docket No. 11-AGL-3] Amendment of Class E Airspace; Mobridge, SD AGENCY: Federal... Mobridge, SD, to accommodate new Area Navigation (RNAV) Standard Instrument Approach Procedures at Mobridge... notice of proposed rulemaking to amend Class E airspace for Mobridge, SD, creating additional controlled...

31 CFR 501.803 - Amendment, modification, or revocation.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Amendment, modification, or revocation. 501.803 Section 501.803 Money and Finance: Treasury Regulations Relating to Money and Finance... REGULATIONS Procedures § 501.803 Amendment, modification, or revocation. Except as otherwise provided by law...

31 CFR 501.803 - Amendment, modification, or revocation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Amendment, modification, or revocation. 501.803 Section 501.803 Money and Finance: Treasury Regulations Relating to Money and Finance... REGULATIONS Procedures § 501.803 Amendment, modification, or revocation. Except as otherwise provided by law...

31 CFR 501.803 - Amendment, modification, or revocation.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Amendment, modification, or revocation. 501.803 Section 501.803 Money and Finance: Treasury Regulations Relating to Money and Finance... REGULATIONS Procedures § 501.803 Amendment, modification, or revocation. Except as otherwise provided by law...

31 CFR 501.803 - Amendment, modification, or revocation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Amendment, modification, or revocation. 501.803 Section 501.803 Money and Finance: Treasury Regulations Relating to Money and Finance... REGULATIONS Procedures § 501.803 Amendment, modification, or revocation. Except as otherwise provided by law...

3 CFR 8691 - Proclamation 8691 of July 1, 2011. 40th Anniversary of the 26th Amendment

Code of Federal Regulations, 2012 CFR

2012-01-01

... of leaders over our history, from the women’s groups of the early 20th century to the civil rights... Amendment was ratified in the shortest time span of any Constitutional Amendment in American history. In the...

78 FR 40043 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-03

....470-4; 216.203-4-70; 225.1101; 225.1103; 225.7605; 229.402-70; and 247.574. List of Subjects in 48 CFR... 52.204-7'' in its place. 225.1103 [Amended] 0 7. Amend paragraph (3) of section 225.1103 by removing...

What difference does a year of schooling make?: Maturation of brain response and connectivity between 2nd and 3rd grades during arithmetic problem solving

PubMed Central

Rosenberg-Lee, Miriam; Barth, Maria; Menon, Vinod

2011-01-01

Early elementary schooling in 2nd and 3rd grades (ages 7-9) is an important period for the acquisition and mastery of basic mathematical skills. Yet, we know very little about neurodevelopmental changes that might occur over a year of schooling. Here we examine behavioral and neurodevelopmental changes underlying arithmetic problem solving in a well-matched group of 2nd (n = 45) and 3rd (n = 45) grade children. Although 2nd and 3rd graders did not differ on IQ or grade- and age-normed measures of math, reading and working memory, 3rd graders had higher raw math scores (effect sizes = 1.46-1.49) and were more accurate than 2nd graders in an fMRI task involving verification of simple and complex two-operand addition problems (effect size = 0.43). In both 2nd and 3rd graders, arithmetic complexity was associated with increased responses in right inferior frontal sulcus and anterior insula, regions implicated in domain-general cognitive control, and in left intraparietal sulcus (IPS) and superior parietal lobule (SPL) regions important for numerical and arithmetic processing. Compared to 2nd graders, 3rd graders showed greater activity in dorsal stream parietal areas right SPL, IPS and angular gyrus (AG) as well as ventral visual stream areas bilateral lingual gyrus (LG), right lateral occipital cortex (LOC) and right parahippocampal gyrus (PHG). Significant differences were also observed in the prefrontal cortex (PFC), with 3rd graders showing greater activation in left dorsal lateral PFC (dlPFC) and greater deactivation in the ventral medial PFC (vmPFC). Third graders also showed greater functional connectivity between the left dlPFC and multiple posterior brain areas, with larger differences in dorsal stream parietal areas SPL and AG, compared to ventral stream visual areas LG, LOC and PHG. No such between-grade differences were observed in functional connectivity between the vmPFC and posterior brain regions. These results suggest that even the narrow one-year interval spanning grades 2 and 3 is characterized by significant arithmetic task-related changes in brain response and connectivity, and argue that pooling data across wide age ranges and grades can miss important neurodevelopmental changes. Our findings have important implications for understanding brain mechanisms mediating early maturation of mathematical skills and, more generally, for educational neuroscience. PMID:21620984

Can the U.S. Do More to Help Avert a World Water Shortage

DTIC Science & Technology

2005-03-18

www.house.gov/ bonilla /23rd.html>. Internet. Accessed 3 October 2004. Savedoff, William D., and Pablo T. Spiller, eds. Spilled Water: Institutional...President Approves More than $127 Million in Funding for 23 rd District,” 5 February 2004, available from <http://www.house.gov/ bonilla /23rd.html>; Internet

75 FR 30372 - Foreign-Trade Zone 38-Spartanburg County, SC; Application for Reorganization/Expansion under...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-01

... Corporate Park, 5675 N. Blackstock Rd., Spartanburg; Site 5 (118 acres)--Key Logistics, 101 Michelin Dr... Site 13 (318 acres)--VMI Logistics Park, Victor Hill Rd., Greer. Because the ASF only pertains to... Center, Brookshire Rd. and SC Hwy. 101, Greer; Site 3 (116 acres total)--Highway 290 Commerce Park, 201...

NREL Battery Calorimeters Win R&D 100 Award | News | NREL

Science.gov Websites

-lasting, and more cost-effective lithium-ion batteries. Understanding and controlling temperature is 3 » NREL Battery Calorimeters Win R&D 100 Award NREL Battery Calorimeters Win R&D 100 Award August 28, 2013 Isothermal Battery Calorimeters (IBCs) developed by the National Renewable Energy

Properties of synaptic transmission from the reticular formation dorsal to the facial nucleus to trigeminal motoneurons during early postnatal development in rats.

PubMed

Gemba-Nishimura, A; Inoue, T; Nakamura, S; Nakayama, K; Mochizuki, A; Shintani, S; Yoshimura, S

2010-03-31

We previously reported that electrical stimulation of the reticular formation dorsal to the facial nucleus (RdVII) elicited excitatory masseter responses at short latencies and that RdVII neurons were antidromically activated by stimulation of the trigeminal motor nucleus (MoV), suggesting that excitatory premotor neurons targeting the MoV are likely located in the RdVII. We thus examined the properties of synaptic transmission from the RdVII to jaw-closing and jaw-opening motoneurons in horizontal brainstem preparations from developing rats using voltage-sensitive dye, patch-clamp recordings and laser photostimulation. Electrical stimulation of the RdVII evoked optical responses in the MoV. Combined bath application of the non-N-methyl-d-aspartate (non-NMDA) receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), and the NMDA receptor antagonist DL-2-amino-5-phosphonopentanoic acid (APV) reduced these optical responses, and addition of the glycine receptor antagonist strychnine and the GABA(A) receptor antagonist bicuculline further reduced the remaining responses. Electrical stimulation of the RdVII evoked postsynaptic currents (PSCs) in all 19 masseter motoneurons tested in postnatal day (P)1-4 rats, and application of CNQX and the NMDA receptor antagonist (+/-)-3(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) reduced the PSC amplitudes by more than 50%. In the presence of CNQX and CPP, the GABA(A) receptor antagonist SR95531 further reduced PSC amplitude, and addition of strychnine abolished the remaining PSCs. Photostimulation of the RdVII with caged glutamate also evoked PSCs in masseter motoneurons of P3-4 rats. In P8-11 rats, electrical stimulation of the RdVII also evoked PSCs in all 14 masseter motoneurons tested, and the effects of the antagonists on the PSCs were similar to those in P1-4 rats. On the other hand, RdVII stimulation evoked PSCs in only three of 16 digastric motoneurons tested. These results suggest that both neonatal and juvenile jaw-closing motoneurons receive strong synaptic inputs from the RdVII through activation of glutamate, glycine and GABA(A) receptors, whereas inputs from the RdVII to jaw-opening motoneurons seem to be weak. Copyright 2010 IBRO. Published by Elsevier Ltd. All rights reserved.

Very Efficient High-order Hyperbolic Schemes for Time-dependent Advection Diffusion Problems: Third-, Fourth-, and Sixth-order

DTIC Science & Technology

2014-07-07

boundary condition (x ¼ 7p =2; j ¼ 2p; U ¼ 1; m ¼ 1) on N ¼ 10 uniform nodes (Dt ¼ 0:01.) Table 10 Unsteady linear advection–diffusion problem with periodic...500 3rd 55 2 4th 55 2 6th 55 2 1000 3rd 116 2 4th 116 2 6th 116 2 Table 11 Unsteady linear advection–diffusion problem with oscillatory BC (x ¼ 7p =2; a...dependent problem with oscillatory BC (x ¼ 7p =2; a ¼ 1.) using the third-order RD-GT scheme with the BDF3 time discretization. Number of nodes Dt (BDF3

Direct Final Rule: Nonroad Diesel Technical Amendments and Tier 3 Technical Relief Provision

EPA Pesticide Factsheets

Rule making certain technical corrections to the rules establishing emission standards for nonroad diesel engines and amending those rules to provide manufacturers with a production technical relief provision for Tier 3 equipment.

TRANSACTIONS OF THE ALL-UNION CONFERENCE ON INFORMATION RETRIEVAL SYSTEMS AND AUTOMATED PROCESSING OF SCIENTIFIC AND TECHNICAL INFORMATION (3rd): PREFACE

DTIC Science & Technology

The research and development of information services within the USSR, reported at the 3rd All-Union Conference on information retrieval systems and automated processing of scientific and technical information, is discussed.

Public Law 96-374--Oct. 3, 1980. An Act to Amend and Extend the Higher Education Act of 1965, and for Other Purposes. 96th Congress.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC.

The text of the Education Amendments of 1980, which amend the Higher Education Act of 1965, is presented. It consists of 13 parts: (1) establishment of a new Title I of the earlier act, establishing new programs, continuing postsecondary education program and planning; (2) amendment and extension of Title II of the earlier act, college and…

Canine RD3 mutation establishes rod cone dysplasia type 2 (rcd2) as ortholog of human and murine rd3

PubMed Central

Kukekova, Anna V.; Goldstein, Orly; Johnson, Jennifer L.; Richardson, Malcolm A.; Pearce-Kelling, Susan E.; Swaroop, Anand; Friedman, James S.; Aguirre, Gustavo D.; Acland, Gregory M.

2009-01-01

Rod cone dysplasia type 2 (rcd2) is an autosomal recessive disorder that segregates in collie dogs. Linkage disequilibrium and meiotic linkage mapping were combined to take advantage of population structure within this breed, and to fine map rcd2 to a 230 kb candidate region that included the gene C1orf36 responsible for human and murine rd3, and within which all affected dogs were homozygous for one haplotype. In one of three identified canine retinal RD3 splice variants, an insertion was found that cosegregates with rcd2, and is predicted to alter the last 61 codons of the normal open reading frame and further extend the ORF. Thus combined meiotic linkage and LD mapping within a single canine breed can yield critical reduction of the disease interval when appropriate advantage is taken of within breed population structure. This should permit a similar approach to tackle other hereditary traits that segregate in single closed populations. PMID:19130129

Vocational Education Amendments of 1968, Reported Without Amendments.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Committee on Education and Labor.

This report, submitted to accompany the Vocational Education Amendments (VT 007 323) presents the reasons behind the House Committee Support, and discusses briefly the changes, which include: (1) purpose and background, (2) authorization of appropriations, (3) required use of state allotments set aside for the disadvantaged, (4) new and expanded…

31 CFR 598.401 - Reference to amended sections.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Reference to amended sections. 598.401 Section 598.401 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE... Interpretations § 598.401 Reference to amended sections. Except as otherwise specified, reference to any provision...

31 CFR 598.401 - Reference to amended sections.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Reference to amended sections. 598.401 Section 598.401 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE... Interpretations § 598.401 Reference to amended sections. Except as otherwise specified, reference to any provision...

31 CFR 598.401 - Reference to amended sections.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Reference to amended sections. 598.401 Section 598.401 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE... Interpretations § 598.401 Reference to amended sections. Except as otherwise specified, reference to any provision...

31 CFR 598.401 - Reference to amended sections.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Reference to amended sections. 598.401 Section 598.401 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE... Interpretations § 598.401 Reference to amended sections. Except as otherwise specified, reference to any provision...

19 CFR 210.14 - Amendments to pleadings and notice; supplemental submissions; counterclaims.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Amendments to pleadings and notice; supplemental submissions; counterclaims. 210.14 Section 210.14 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Pleadings § 210.14 Amendments to...

19 CFR 210.14 - Amendments to pleadings and notice; supplemental submissions; counterclaims.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 3 2011-04-01 2011-04-01 false Amendments to pleadings and notice; supplemental submissions; counterclaims. 210.14 Section 210.14 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Pleadings § 210.14 Amendments to...

19 CFR 210.57 - Amendment of the motion.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Amendment of the motion. 210.57 Section 210.57 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Temporary Relief § 210.57 Amendment of the motion. A motion for...

15 CFR 923.83 - Mediation of amendments.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Mediation of amendments. 923.83... Programs § 923.83 Mediation of amendments. (a) Section 307(h)(2) of the Act provides for mediation of... management program. Accordingly mediation is available to states or federal agencies when a serious...

5 CFR 2100.8 - Review of request for amendment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Review of request for amendment. 2100.8 Section 2100.8 Administrative Personnel ARMED FORCES RETIREMENT HOME ARMED FORCES RETIREMENT HOME PRIVACY... of a request for amendment of a record will be provided to the requester within 10 working days...

78 FR 45849 - Amendment of Class E Airspace; Gustavus, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-30

...-0282; Airspace Docket No. 13-AAL-3] Amendment of Class E Airspace; Gustavus, AK AGENCY: Federal... Gustavus Airport, Gustavus, AK. Decommissioning of the Gustavus Nondirectional Radio Beacon (NDB) has made... Register a notice of proposed rulemaking (NPRM) to amend controlled airspace at Gustavus, AK (78 FR 31871...

21 CFR 171.6 - Amendment of petition.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Amendment of petition. 171.6 Section 171.6 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVE PETITIONS General Provisions § 171.6 Amendment of petition. After a...

21 CFR 171.6 - Amendment of petition.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Amendment of petition. 171.6 Section 171.6 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVE PETITIONS General Provisions § 171.6 Amendment of petition...

21 CFR 171.6 - Amendment of petition.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Amendment of petition. 171.6 Section 171.6 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVE PETITIONS General Provisions § 171.6 Amendment of petition...

Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa.

PubMed

Sánchez-Cruz, Alonso; Villarejo-Zori, Beatriz; Marchena, Miguel; Zaldivar-Díez, Josefa; Palomo, Valle; Gil, Carmen; Lizasoain, Ignacio; de la Villa, Pedro; Martínez, Ana; de la Rosa, Enrique J; Hernández-Sánchez, Catalina

2018-04-16

Retinitis pigmentosa (RP) is a group of hereditary retinal neurodegenerative conditions characterized by primary dysfunction and death of photoreceptor cells, resulting in visual loss and, eventually, blindness. To date, no effective therapies have been transferred to clinic. Given the diverse genetic etiology of RP, targeting common cellular and molecular retinal alterations has emerged as a potential therapeutic strategy. Using the Pde6b rd10/rd10 mouse model of RP, we investigated the effects of daily intraperitoneal administration of VP3.15, a small-molecule heterocyclic GSK-3 inhibitor. Gene expression was analyzed by quantitative PCR and protein expression and phosphorylation by Western blot. Photoreceptor preservation was evaluated by histological analysis and visual function was assessed by electroretinography. In rd10 retinas, increased expression of pro-inflammatory markers and reactive gliosis coincided with the early stages of retinal degeneration. Compared with wild-type controls, GSK-3β expression (mRNA and protein) remained unchanged during the retinal degeneration period. However, levels of GSK-3β Ser9 and its regulator Akt Ser473 were increased in rd10 versus wild-type retinas. In vivo administration of VP3.15 reduced photoreceptor cell loss and preserved visual function. This neuroprotective effect was accompanied by a decrease in the expression of neuroinflammatory markers. These results provide proof of concept of the therapeutic potential of VP3.15 for the treatment of retinal neurodegenerative conditions in general, and RP in particular.

25 CFR 273.3 - Revision or amendment of regulations.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Revision or amendment of regulations. 273.3 Section 273.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT General Provisions § 273.3 Revision or...

25 CFR 273.3 - Revision or amendment of regulations.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Revision or amendment of regulations. 273.3 Section 273.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT General Provisions § 273.3 Revision or...

25 CFR 273.3 - Revision or amendment of regulations.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true Revision or amendment of regulations. 273.3 Section 273.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT General Provisions § 273.3 Revision or...

25 CFR 273.3 - Revision or amendment of regulations.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false Revision or amendment of regulations. 273.3 Section 273.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT General Provisions § 273.3 Revision or...

25 CFR 273.3 - Revision or amendment of regulations.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false Revision or amendment of regulations. 273.3 Section 273.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT General Provisions § 273.3 Revision or...

29 CFR 1910.3 - Petitions for the issuance, amendment, or repeal of a standard.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 5 2011-07-01 2011-07-01 false Petitions for the issuance, amendment, or repeal of a standard. 1910.3 Section 1910.3 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS General § 1910.3...

29 CFR 1910.3 - Petitions for the issuance, amendment, or repeal of a standard.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 5 2012-07-01 2012-07-01 false Petitions for the issuance, amendment, or repeal of a standard. 1910.3 Section 1910.3 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS General § 1910.3...

Reactions of Ions with Ionic Liquid Vapors by Selected-Ion Flow Tube Mass Spectrometry

DTIC Science & Technology

2011-03-29

Emel’yanenko, V. N.; Verevkin, S. P.; Heintz, A.; Corfield, J.-A.; Deyko, A.; Lovelock , K. R. J.; Licence, P.; Jones, R. G. Pyrrolidinium- Based Ionic...112, 11734–11742. (2) Lovelock , K. R. J.; Deyko, A.; Licence, P.; Jones, R. G. Vaporisa- tion of an Ionic Liquid Near Room Temperature. Phys. Chem...Relevance of pKa from Aqueous Solutions. J. Am. Chem. Soc. 2003, 125, 15411–15419. (15) Armstrong, J. P.; Hurst, C.; Jones, R. G.; Licence, P.; Lovelock , K

Heats of Vaporization of Room Temperature Ionic Liquids by Tunable Vacuum Ultraviolet Photoionization

DTIC Science & Technology

2009-12-07

18) Emel’yanenko, V. N.; Verevkin, S. P.; Heintz, A.; Corfield, J.-A.; deyko, A.; Lovelock , K. R. J.; Licence, P.; Jones, R. G. J. Phys. Chem. B 2008...112, 11734. (19) Armstrong, J. P.; Hurst, C.; Jones, R. G.; Licence, P.; Lovelock , K. R. J.; Satterly, C. J.; Villar-Garcia, I. J. Phys. Chem. Chem...Phys. 2007, 9, 982. (20) Lovelock , K. R. J.; Deyko, A.; Corfield, J.-A.; Gooden, P. N.; Licence, P.; Jones, R. G. ChemPhysChem 2009, 10, 337. (21

Broad-spectrum non-nucleoside inhibitors for caliciviruses.

PubMed

Netzler, Natalie E; Enosi Tuipulotu, Daniel; Eltahla, Auda A; Lun, Jennifer H; Ferla, Salvatore; Brancale, Andrea; Urakova, Nadya; Frese, Michael; Strive, Tanja; Mackenzie, Jason M; White, Peter A

2017-10-01

Viruses of the Caliciviridae cause significant and sometimes lethal diseases, however despite substantial research efforts, specific antivirals are lacking. Broad-spectrum antivirals could combat multiple viral pathogens, offering a rapid solution when no therapies exist. The RNA-dependent RNA polymerase (RdRp) is an attractive antiviral target as it is essential for viral replication and lacks mammalian homologs. To focus the search for pan-Caliciviridae antivirals, the RdRp was probed with non-nucleoside inhibitors (NNIs) developed against hepatitis C virus (HCV) to reveal both allosteric ligands for structure-activity relationship enhancement, and highly-conserved RdRp pockets for antiviral targeting. The ability of HCV NNIs to inhibit calicivirus RdRp activities was assessed using in vitro enzyme and murine norovirus cell culture assays. Results revealed that three NNIs which bound the HCV RdRp Thumb I (TI) site also inhibited transcriptional activities of six RdRps spanning the Norovirus, Sapovirus and Lagovirus genera of the Caliciviridae. These NNIs included JTK-109 (RdRp inhibition range: IC 50 4.3-16.6 μM), TMC-647055 (IC 50 range: 18.8-45.4 μM) and Beclabuvir (IC 50 range: 23.8->100 μM). In silico studies and site-directed mutagenesis indicated the JTK-109 binding site was within the calicivirus RdRp thumb domain, in a pocket termed Site-B, which is highly-conserved within all calicivirus RdRps. Additionally, RdRp inhibition assays revealed that JTK-109 was antagonistic with the previously reported RdRp inhibitor pyridoxal-5'-phosphate-6-(2'-naphthylazo-6'-nitro-4',8'-disulfonate) tetrasodium salt (PPNDS), that also binds to Site-B. Moreover, like JTK-109, PPNDS was also a potent inhibitor of polymerases from six viruses spanning the three Caliciviridae genera tested (IC 50 range: 0.1-2.3 μM). Together, this study demonstrates the potential for de novo development of broad-spectrum antivirals that target the highly-conserved RdRp thumb pocket, Site-B. We also revealed three broad-spectrum HCV NNIs that could be used as antiviral scaffolds for further development against caliciviruses and other viruses. Copyright © 2017 Elsevier B.V. All rights reserved.

The Effect of Chemical Amendments Used for Phosphorus Abatement on Greenhouse Gas and Ammonia Emissions from Dairy Cattle Slurry: Synergies and Pollution Swapping.

PubMed

Brennan, Raymond B; Healy, Mark G; Fenton, Owen; Lanigan, Gary J

2015-01-01

Land application of cattle slurry can result in incidental and chronic phosphorus (P) loss to waterbodies, leading to eutrophication. Chemical amendment of slurry has been proposed as a management practice, allowing slurry nutrients to remain available to plants whilst mitigating P losses in runoff. The effectiveness of amendments is well understood but their impacts on other loss pathways (so-called 'pollution swapping' potential) and therefore the feasibility of using such amendments has not been examined to date. The aim of this laboratory scale study was to determine how the chemical amendment of slurry affects losses of NH3, CH4, N2O, and CO2. Alum, FeCl2, Polyaluminium chloride (PAC)- and biochar reduced NH3 emissions by 92, 54, 65 and 77% compared to the slurry control, while lime increased emissions by 114%. Cumulative N2O emissions of cattle slurry increased when amended with alum and FeCl2 by 202% and 154% compared to the slurry only treatment. Lime, PAC and biochar resulted in a reduction of 44, 29 and 63% in cumulative N2O loss compared to the slurry only treatment. Addition of amendments to slurry did not significantly affect soil CO2 release during the study while CH4 emissions followed a similar trend for all of the amended slurries applied, with an initial increase in losses followed by a rapid decrease for the duration of the study. All of the amendments examined reduced the initial peak in CH4 emissions compared to the slurry only treatment. There was no significant effect of slurry amendments on global warming potential (GWP) caused by slurry land application, with the exception of biochar. After considering pollution swapping in conjunction with amendment effectiveness, the amendments recommended for further field study are PAC, alum and lime. This study has also shown that biochar has potential to reduce GHG losses arising from slurry application.

The Effect of Chemical Amendments Used for Phosphorus Abatement on Greenhouse Gas and Ammonia Emissions from Dairy Cattle Slurry: Synergies and Pollution Swapping

PubMed Central

Brennan, Raymond B.; Healy, Mark G.; Fenton, Owen; Lanigan, Gary J.

2015-01-01

Land application of cattle slurry can result in incidental and chronic phosphorus (P) loss to waterbodies, leading to eutrophication. Chemical amendment of slurry has been proposed as a management practice, allowing slurry nutrients to remain available to plants whilst mitigating P losses in runoff. The effectiveness of amendments is well understood but their impacts on other loss pathways (so-called ‘pollution swapping’ potential) and therefore the feasibility of using such amendments has not been examined to date. The aim of this laboratory scale study was to determine how the chemical amendment of slurry affects losses of NH3, CH4, N2O, and CO2. Alum, FeCl2, Polyaluminium chloride (PAC)- and biochar reduced NH3 emissions by 92, 54, 65 and 77% compared to the slurry control, while lime increased emissions by 114%. Cumulative N2O emissions of cattle slurry increased when amended with alum and FeCl2 by 202% and 154% compared to the slurry only treatment. Lime, PAC and biochar resulted in a reduction of 44, 29 and 63% in cumulative N2O loss compared to the slurry only treatment. Addition of amendments to slurry did not significantly affect soil CO2 release during the study while CH4 emissions followed a similar trend for all of the amended slurries applied, with an initial increase in losses followed by a rapid decrease for the duration of the study. All of the amendments examined reduced the initial peak in CH4 emissions compared to the slurry only treatment. There was no significant effect of slurry amendments on global warming potential (GWP) caused by slurry land application, with the exception of biochar. After considering pollution swapping in conjunction with amendment effectiveness, the amendments recommended for further field study are PAC, alum and lime. This study has also shown that biochar has potential to reduce GHG losses arising from slurry application. PMID:26053923

Sensory irritating potency of some microbial volatile organic compounds (MVOCs) and a mixture of five MVOCs.

PubMed

Korpi, A; Kasanen, J P; Alarie, Y; Kosma, V M; Pasanen, A L

1999-01-01

The authors investigated the ability/potencies of 3 microbial volatile organic compounds and a mixture of 5 microbial volatile organic compounds to cause eye and upper respiratory tract irritation (i.e., sensory irritation), with an animal bioassay. The authors estimated potencies by determining the concentration capable of decreasing the respiratory frequency of mice by 50% (i.e., the RD50 value). The RD50 values for 1-octen-3-ol, 3-octanol, and 3-octanone were 182 mg/m3 (35 ppm), 1359 mg/m3 (256 ppm), and 17586 mg/m3 (3360 ppm), respectively. Recommended indoor air levels calculated from the individual RD50 values for 1-octen-3-ol, 3-octanol, and 3-octanone were 100, 1000, and 13000 microg/m3, respectively-values considerably higher than the reported measured indoor air levels for these compounds. The RD50 value for a mixture of 5 microbial volatile organic compounds was also determined and found to be 3.6 times lower than estimated from the fractional concentrations and the respective RD50s of the individual components. The data support the conclusion that a variety of microbial volatile organic compounds may have some synergistic effects for the sensory irritation response, which constrains the interpretation and application of recommended indoor air levels of individual microbial volatile organic compounds. The results also showed that if a particular component of a mixture was much more potent than the other components, it may dominate the sensory irritation effect. With respect to irritation symptoms reported in moldy houses, the results of this study indicate that the contribution of microbial volatile organic compounds to these symptoms seems less than previously supposed.

Retinal detachment in horses: 40 cases (1998-2005).

PubMed

Strobel, Brian W; Wilkie, David A; Gilger, Brian C

2007-01-01

To determine clinical features, ophthalmic examination findings, etiology, treatment, and outcome of horses diagnosed with retinal detachment (RD). Forty horses, presented to the North Carolina State University and The Ohio State University Veterinary Teaching Hospitals from 1998 to 2005 that were diagnosed with RD. PROCEDURE(S): Horses with documented RD, confirmed either on ophthalmic examination or by ultrasonography, and with a complete medical record were included. Information retrieved from the medical records included signalment, presenting complaint, duration of clinical signs, ophthalmologic examination findings, diagnostics performed, identified cause of the retinal detachment, treatment given, and outcome. Forty horses (46 eyes) were diagnosed with RD. Mean +/- SD duration of clinical signs of ocular disease was 10.5 +/- 14.7 months. Thirty-four horses presented with unilateral involvement, 6 with bilateral, 14 with partial and 32 with complete RD. Ultrasonography was used to make the diagnosis in 26 eyes, while RD was diagnosed on routine ocular examination in 20 eyes. Bullous RD was the only type of RD observed, although small vitreal traction bands were considered secondary to the underlying inflammation or trauma. RD caused by equine recurrent uveitis (ERU) was diagnosed in 27 of 40 (67.5%) horses. Trauma-induced RD involved 10 of the 40 horses (25%). Presenting problems included known ERU (n = 16), acute or progressive vision loss (n = 9), known ocular trauma (n = 6), cataract (n = 6), and a cloudy cornea (n = 3). No horses regained vision after RD despite therapy. Many eyes were enucleated or eviscerated, or the horses were euthanized. Seven eyes with complete RD were noted to be unchanged and comfortable with medical therapy. The visual prognosis of RD in horses is grave; however, horses with nontraumatic RD (most commonly ERU) may be able to maintain a comfortable but blind globe with anti-inflammatory medical therapy.

Turkish Young Children's Views on Science and Scientists

ERIC Educational Resources Information Center

Ozgelen, Sinan

2012-01-01

The purpose of the study was to investigate 3rd grade primary students' views on science and scientists. The sample consisted of 254 3rd grade public school students in Mersin. Primary students were asked to answer three basic questions; 1) What is science? 2) Who does science? 3) How is science done? Primary students were requested to give…

[Clinical Evaluation of Diagnostic and Treatment Protocol of Idiopathic Retroperitoneal Fibrosis Incorporating Consideration of Possible IgG4-Related Disease].

PubMed

Iyoki, Takaya; Maehana, Takeshi; Tanaka, Toshiaki; Yamamoto, Motohisa; Takahashi, Hiroki; Masumori, Naoya

2017-11-01

About half of idiopathic retroperitoneal fibrosis might be classified as a IgG4-related disease, a newly characterized disease that is especially known to be sensitive to steroid therapy. We developed a new protocol for diagnosis and treatment of retroperitoneal fibrosis, which included aggressive diagnosis of IgG4- related disease. We retrospectively reviewed 22 cases with idiopathic retroperitoneal fibrosis that were diagnosed and treated according to our protocol. Of them, 10 patients (45.5%) had no evidence of IgG4- related disease (non-IgG4RD group), whereas 12 patients (54.5%) were diagnosed with IgG4-related disease (IgG4RD group). All patients received steroid therapy, and 13 patients (59.1%) underwent ureteral stenting or received prednisolone (PNS). There was no severe adverse event and planned steroid therapy was completed in all patients. In principle, maintenance steroid therapy was continued after induction therapy in the IgG4RD group, whereas steroid therapy was discontinued in the non-IgG4RD group. Regression of retroperitoneal plaque was achieved in all 22 patients. Four (57.1%) out of 7 patients and 3 (50.0%) out of 6 patients achieved freedom from ureteral stent or PNS in the non-IgG4RD group and IgG4RD group, respectively. All 3 patients with PNS became catheter-free after treatment, whereas only 4 (40.0%) of the 10 patients withureteral stent could become stent-free. Steroid therapy could be discontinued in 7 patients (70.0%) in the non-IgG4RD group. The results of this study suggest that similar efficacy of steroid therapy can be expected in the non-IgG4RD group and IgG4RD group.

76 FR 56775 - New York; Amendment No. 3 to Notice of a Major Disaster Declaration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-14

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Internal Agency Docket No. FEMA-4020-DR; Docket ID FEMA-2011-0001] New York; Amendment No. 3 to Notice of a Major Disaster..., and related determinations. DATES: Effective Date: September 3, 2011. FOR FURTHER INFORMATION CONTACT...

75 FR 27272 - Amateur Service Rules

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-14

... 3. Pursuant to Sec. Sec. 1.415 and 1.419 of the Commission's rules, interested parties may file... dominant in its field of operation; and (3) satisfies any additional criteria established by the Small... noted. Sec. 97.313 [Amended] 2. Section 97.311 is amended by removing paragraph (d). 3. Section 97.313...

Trends & Indicators: NE Universities Still R&D Powerhouses

ERIC Educational Resources Information Center

Harney, John O.

2011-01-01

New England universities performed more than $4 billion worth of research and development (R&D) in 2009, but the region's share of total R&D performed by all U.S. universities remained at 7.3%, down from more than 10% in the 1980s. The region's university research labs have been world-famous for ideas that breed companies and whole…

Evaluation of soil amendments as a remediation alternative for cadmium-contaminated soils under cacao plantations.

PubMed

Chavez, E; He, Z L; Stoffella, P J; Mylavarapu, R; Li, Y; Baligar, V C

2016-09-01

Elevated plant-available cadmium (Cd) in soils results in contamination to cacao (Theobroma cacao L) beans. Effectiveness of vermicompost and zeolite in reducing available Cd in three cacao-growing soils was studied under laboratory conditions. Sorption-desorption experiments were conducted in soils and amendments. Cadmium was added at 0 or 5 mg kg(-1) (spiked), then, amendments were incorporated at 0, 0.5, or 2 %. Amended soils were incubated at room temperature for 28 days. Plant-available Cd was determined using 0.01 M CaCl2 (WSE) and Mehlich 3 (M3) extraction procedures in subsamples taken from individual bags at six time intervals. Soils and amendments displayed different sorption characteristics and a better fit was attained with Freundlich model (R (2) > 0.82). Amendments were ineffective in reducing extractable Cd in non-spiked soils. In Cd-spiked soils, vermicompost at 2 % significantly reduced WSE-Cd (P < 0.01) from 3.36, 0.54, and 0.38 mg kg(-1) to values lower that instrument's detection in all the three soils and significantly diminished M3-extractable Cd (P < 0.05) from 4.62 to 4.11 mg kg(-1) in only one soil. Vermicompost at 0.5 % significantly decreased WSE-Cd (P < 0.01) from 3.04 and 0.31 to 1.69 and 0.20 mg kg(-1), respectively, in two soils with low sorption capacity for Cd. In contrast, zeolite failed to reduce WSE- or M3-extractable Cd in all studied soils. A negative correlation occurred between soil pH and WSE-Cd (r > -0.89, P < 0.01). The decrease in WSE-Cd appears to be associated with the increase in pH of the vermicompost-amended soils.

Sorption-desorption equilibrium and diffusion of tetracycline in poultry litter and municipal biosolids soil amendments.

PubMed

D'Angelo, E

2017-12-01

Tetracycline (TET) is commonly used to treat bacterial diseases in humans and chickens (Gallus gallus domesticus), is largely excreted, and is found at elevated concentrations in treated sewage sludge (biosolids) and poultry litter (excrement plus bedding materials). Routine application of these nutrient-and carbon-enriched materials to soils improves fertility and other characteristics, but the presence of antibiotics (and other pharmaceuticals) in amendments raises questions about potential adverse effects on biota and development of antibiotic resistance in the environment. Hazard risks are largely dictated by sorption-desorption and diffusion behavior in amendments, so these processes were evaluated from sorption-desorption equilibrium isotherm and diffusion cell experiments with four types amendments (biosolids, poultry manure, wood chip litter, and rice hull litter) at three temperatures (8 °C, 20 °C and 32 °C). Linear sorption-desorption equilibrium distribution constants (Kd) in native amendments ranged between 124-2418 L kg -1 . TET sorption was significantly increased after treatment with alum, and there was a strong exponential relationship between Kd and the concentration of bound Al 3+ in amendments (R 2  = 0.94), which indicated that amendments contained functional groups capable of chelating Al 3+ and forming metal bridges with TET. Effective diffusion coefficients of TET in amendments ranged between 0.1 and 5.2 × 10 -6  cm 2  s -1 , which were positively related to temperature and inversely related to Kd by a multiple regression model (R 2  = 0.86). Treatment of organic amendments with alum greatly increased Kd, would decrease D s , and so would greatly reduce hazard risks of applying these organic amendments with this antibiotic to soils. Copyright © 2017 Elsevier Ltd. All rights reserved.

Resolution and quantification accuracy enhancement of functional delay and sum beamforming for three-dimensional acoustic source identification with solid spherical arrays

NASA Astrophysics Data System (ADS)

Chu, Zhigang; Yang, Yang; Shen, Linbang

2017-05-01

Functional delay and sum (FDAS) is a novel beamforming algorithm introduced for the three-dimensional (3D) acoustic source identification with solid spherical microphone arrays. Being capable of offering significantly attenuated sidelobes with a fast speed, the algorithm promises to play an important role in interior acoustic source identification. However, it presents some intrinsic imperfections, specifically poor spatial resolution and low quantification accuracy. This paper focuses on conquering these imperfections by ridge detection (RD) and deconvolution approach for the mapping of acoustic sources (DAMAS). The suggested methods are referred to as FDAS+RD and FDAS+RD+DAMAS. Both computer simulations and experiments are utilized to validate their effects. Several interesting conclusions have emerged: (1) FDAS+RD and FDAS+RD+DAMAS both can dramatically ameliorate FDAS's spatial resolution and at the same time inherit its advantages. (2) Compared to the conventional DAMAS, FDAS+RD+DAMAS enjoys the same super spatial resolution, stronger sidelobe attenuation capability and more than two hundred times faster speed. (3) FDAS+RD+DAMAS can effectively conquer FDAS's low quantification accuracy. Whether the focus distance is equal to the distance from the source to the array center or not, it can quantify the source average pressure contribution accurately. This study will be of great significance to the accurate and quick localization and quantification of acoustic sources in cabin environments.

PRN 93-8: Labeling Statement Prohibiting Application to Water; Amendment to PR Notice 93-3

EPA Pesticide Factsheets

This notice adds one paragraph to P.R. Notice 93-3, which requested registrants to amend product labeling to include a new labeling statement prohibiting application of a pesticide to water for certain products.

Proposed Rule for Amendments Related to: Tier 3 Motor Vehicle Emission and Fuel Standards, Nonroad Engine and Equipment

EPA Pesticide Factsheets

Link to Federal Register Notice from February 19, 2015 announcing Amendments Related to: Tier 3 Motor Vehicle Emission and Fuel Standards, Nonroad Engine and Equipment Programs, and MARPOL Annex VI Implementation.

40 CFR 305.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND... (CERCLA) ADMINISTRATIVE HEARING PROCEDURES FOR CLAIMS AGAINST THE SUPERFUND General § 305.3 Definitions... Liability Act of 1980 as amended by the Superfund Amendments and Reauthorization Act of 1986 (SARA), 42 U.S...

40 CFR 305.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND... (CERCLA) ADMINISTRATIVE HEARING PROCEDURES FOR CLAIMS AGAINST THE SUPERFUND General § 305.3 Definitions... Liability Act of 1980 as amended by the Superfund Amendments and Reauthorization Act of 1986 (SARA), 42 U.S...

40 CFR 305.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND... (CERCLA) ADMINISTRATIVE HEARING PROCEDURES FOR CLAIMS AGAINST THE SUPERFUND General § 305.3 Definitions... Liability Act of 1980 as amended by the Superfund Amendments and Reauthorization Act of 1986 (SARA), 42 U.S...

76 FR 69793 - Audit and Financial Management Advisory (AFMAC)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-09

... Street SW., Office of the Chief Financial Officer, Washington, DC 20416. SUPPLEMENTARY INFORMATION... fax or email, in order to be placed on the agenda. Jonathan Carver, Chief Financial Officer, 409 3rd... Financial Officer, 409 3rd Street SW., Washington, DC 20416. For more information, please visit our Web site...

76 FR 64990 - Audit and Financial Management Advisory (AFMAC)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-19

... Street, SW., Office of the Chief Financial Officer, Washington, DC 20416. SUPPLEMENTARY INFORMATION..., in order to be placed on the agenda. Jonathan Carver, Chief Financial Officer, 409 3rd Street, SW... Chief Financial Officer, 409 3rd Street, SW., Washington, DC 20416. For more information, please visit...

77 FR 64373 - Audit and Financial Management Advisory (AFMAC)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-19

... the Chief Financial Officer Conference Room, 6th Floor, Washington, DC 20416. SUPPLEMENTARY.... Jonathan Carver, Chief Financial Officer, 409 3rd Street SW., 6th Floor, Washington, DC 20416, phone: (202...-1608, email: [email protected] ; SBA, Office of Chief Financial Officer, 409 3rd Street SW...

The National Shipbuilding Research Program. Design for Production Manual 2nd Edition

DTIC Science & Technology

1999-07-01

New York, 1979 Montgomery, Douglas C., Introduction to Statistical Quality Control, 3rd Edition, John Wiley & Sons, New York, 1997 Ishikawa , Kaoru ...references: Feigenbaum, A.V., Total Quality Control: Engineering and Management, 3rd edition, New York McGraw Hill, 1983. Ishikawa , Kaouro., Guide to

2. Historic American Building Survey History of Sacramento County Thompson ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Building Survey History of Sacramento County Thompson & West Illustration Original 1880 Rephoto 1960 N.W. Corner of 3rd + P ST., SOUTH HOUSE (Property of Mrs. E.B. Crocker, 3rd & P St.) - Crocker Art Gallery, 216 O Street, Sacramento, Sacramento County, CA

Developments in Processing by Severe Plastic Deformation at the 3rd Pan American Materials Congress

NASA Astrophysics Data System (ADS)

Figueiredo, Roberto B.; Kawasaki, Megumi; Langdon, Terence G.

2017-10-01

The 3rd Pan American Materials Congress in San Diego, California, February 26-March 2, 2017, provided an opportunity to bring together many participants working in the field of severe plastic deformation. This article provides a brief review of these activities.

Conducting clinical trials in Singapore.

PubMed

Woo, K T

1999-04-01

All clinical trials in Singapore will now have to conform to the Medicines (Clinical Trials) Amended Regulations 1998 and the Singapore Good Clinical Practice (GCP) Guidelines 1998. The Medical Clinical Research Committee (MCRC) has been established to oversee the conduct of clinical drug trials in Singapore and together with the legislations in place, these will ensure that clinical trials conducted in Singapore are properly controlled and the well-being of trial subjects are safe guarded. All clinical drug trials require a Clinical Trial Certificate from the MCRC before the trial can proceed. The hospital ethics committee (EC) vets the application for a trial certificate before it is sent to MCRC. The drug company sponsoring the trial has to indemnify the trial investigators and the hospital for negligence arising from the trial. The MCRC, apart from ensuring the safety of trial subjects, has to provide continuing review of the clinical trial and monitors adverse events in the course of the trial. The EC will conduct continuing review of clinical trials. When a non-drug clinical trial is carried out, the EC will ensure that the proposed protocol addresses ethical concerns and meets regulatory requirements for such trials. There is great potential for pharmaceutical Research & Development (R&D) in Singapore. We must develop our skills and infrastructure in clinical trials to enable Singapore to be a regional hub for R&D of drugs in Asia.

77 FR 49399 - Proposed Amendment of Class E Airspace; Forest City, IA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-16

...-0654; Airspace Docket No. 12-ACE-3] Proposed Amendment of Class E Airspace; Forest City, IA AGENCY... action proposes to amend Class E airspace at Forest City, IA. Additional controlled airspace is necessary... accommodate new standard instrument approach procedures at Forest City Municipal Airport, Forest City, IA. The...

77 FR 68683 - Amendment of Class E Airspace; Forest City, IA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-16

...-0654; Airspace Docket No. 12-ACE-3] Amendment of Class E Airspace; Forest City, IA AGENCY: Federal... Forest City, IA. Additional controlled airspace is necessary to accommodate new Area Navigation (RNAV... Federal Register a notice of proposed rulemaking (NPRM) to amend Class E airspace for the Forest City, IA...

17 CFR 260.7a-36 - Signatures to amendments.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Signatures to amendments. 260.7a-36 Section 260.7a-36 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, TRUST INDENTURE ACT OF 1939 Amendments § 260.7a-36 Signatures to...

75 FR 3765 - Options Price Reporting Authority; Notice of Filing and Immediate Effectiveness of Proposed...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-22

... Reporting Authority; Notice of Filing and Immediate Effectiveness of Proposed Amendment To Revise the Plan... (``Commission'') an amendment to the Plan for Reporting of Consolidated Options Last Sale Reports and Quotation Information (``OPRA Plan'').\\3\\ The proposed amendment would revise the OPRA Plan for the sole purpose of...

30 CFR 938.25 - Approval of Pennsylvania abandoned mine land reclamation plan amendments.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Approval of Pennsylvania abandoned mine land reclamation plan amendments. 938.25 Section 938.25 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND... STATE PENNSYLVANIA § 938.25 Approval of Pennsylvania abandoned mine land reclamation plan amendments...

30 CFR 948.25 - Approval of West Virginia abandoned mine lands reclamation plan amendments.

Code of Federal Regulations, 2014 CFR

2014-07-01

... March 26, 1993 Amendments contained in House Bill 2492; Expanded eligibility criteria; Acid mine... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Approval of West Virginia abandoned mine lands... STATE WEST VIRGINIA § 948.25 Approval of West Virginia abandoned mine lands reclamation plan amendments...

30 CFR 948.25 - Approval of West Virginia abandoned mine lands reclamation plan amendments.

Code of Federal Regulations, 2013 CFR

2013-07-01

... March 26, 1993 Amendments contained in House Bill 2492; Expanded eligibility criteria; Acid mine... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Approval of West Virginia abandoned mine lands... STATE WEST VIRGINIA § 948.25 Approval of West Virginia abandoned mine lands reclamation plan amendments...

30 CFR 948.25 - Approval of West Virginia abandoned mine lands reclamation plan amendments.

Code of Federal Regulations, 2012 CFR

2012-07-01

... March 26, 1993 Amendments contained in House Bill 2492; Expanded eligibility criteria; Acid mine... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Approval of West Virginia abandoned mine lands... STATE WEST VIRGINIA § 948.25 Approval of West Virginia abandoned mine lands reclamation plan amendments...

78 FR 73749 - Proposed Amendment of Class D Airspace; St. Joseph, MO

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-09

...-0917; Airspace Docket No. 13-ACE-16] Proposed Amendment of Class D Airspace; St. Joseph, MO AGENCY... action proposes to amend Class D airspace at St. Joseph, MO. Additional controlled airspace is necessary... Rosecrans Municipal Airport, St. Joseph, MO. Accordingly, additional segments would extend from the 4.3-mile...

30 CFR 906.25 - Approval of Colorado abandoned mine land reclamation plan amendments.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Approval of Colorado abandoned mine land reclamation plan amendments. 906.25 Section 906.25 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND... STATE COLORADO § 906.25 Approval of Colorado abandoned mine land reclamation plan amendments. The...

75 FR 37288 - Kiwifruit Grown in California; Order Amending Marketing Order No. 920

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-29

... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 920 [Doc. No. AO-FV-08-0174; AMS-FV-08-0085; FV08-920-3] Kiwifruit Grown in California; Order Amending Marketing Order No. 920 AGENCY: Agricultural Marketing Service, USDA. ACTION: Final rule. SUMMARY: This rule amends Marketing...

76 FR 4201 - Kiwifruit Grown in California; Order Amending Marketing Order No. 920; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-25

... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 920 [Doc. No. AO-FV-08-0174; AMS-FV-08-0085; FV08-920-3 C] Kiwifruit Grown in California; Order Amending Marketing Order No. 920; Correction AGENCY: Agricultural Marketing Service, USDA. ACTION: Correcting amendment. SUMMARY: This document...

78 FR 31584 - Notice of Proposed Amendment to Prohibited Transaction Exemption 80-26 (PTE 80-26) For Certain...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-24

...This document contains a notice of pendency before the Department of Labor (the Department) of a proposed amendment to PTE 80- 26. PTE 80-26 is a class exemption that permits parties in interest with respect to employee benefit plans to make certain interest free loans and extensions of credit to such plans, provided the conditions of the exemption are met. The proposed amendment, if adopted, would give retroactive and temporary exemptive relief for certain guarantees of the payment of debits to plan investment accounts (including IRAs) by parties in interest to such plans as well as certain loans and loan repayments made pursuant to such guarantees. The proposed amendment would affect employee benefit plans described in section 3(3) of the Employee Retirement Income Security Act of 1974, as amended (ERISA or the Act), and plans described in section 4975(e)(1) of the Internal Revenue Code of 1986, as amended (the Code), the participants and beneficiaries of such plans, and parties in interest with respect to those plans engaging in the described transactions.

76 FR 1985 - Airworthiness Directives; Short Brothers PLC Model SD3 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-12

... Airworthiness Directives; Short Brothers PLC Model SD3 Airplanes AGENCY: Federal Aviation Administration (FAA..., June 16, 2006) and adding the following new AD: 2010-24-06 Short Brothers PLC: Amendment 39-16525..., Amendment 39-14644. Applicability (c) This AD applies to all Short Brothers PLC Model SD3-60 SHERPA, SD3...

38 CFR 3.715 - Radiation Exposure Compensation Act of 1990, as amended.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Radiation Exposure... Benefits and Elections § 3.715 Radiation Exposure Compensation Act of 1990, as amended. (a) Compensation. (1) A radiation-exposed veteran, as defined in 38 CFR 3.309(d)(3), who receives a payment under the...

38 CFR 3.715 - Radiation Exposure Compensation Act of 1990, as amended.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Radiation Exposure... Benefits and Elections § 3.715 Radiation Exposure Compensation Act of 1990, as amended. (a) Compensation. (1) A radiation-exposed veteran, as defined in 38 CFR 3.309(d)(3), who receives a payment under the...

38 CFR 3.715 - Radiation Exposure Compensation Act of 1990, as amended.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Radiation Exposure... Benefits and Elections § 3.715 Radiation Exposure Compensation Act of 1990, as amended. (a) Compensation. (1) A radiation-exposed veteran, as defined in 38 CFR 3.309(d)(3), who receives a payment under the...

38 CFR 3.715 - Radiation Exposure Compensation Act of 1990, as amended.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Radiation Exposure... Benefits and Elections § 3.715 Radiation Exposure Compensation Act of 1990, as amended. (a) Compensation. (1) A radiation-exposed veteran, as defined in 38 CFR 3.309(d)(3), who receives a payment under the...

38 CFR 3.715 - Radiation Exposure Compensation Act of 1990, as amended.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Radiation Exposure... Benefits and Elections § 3.715 Radiation Exposure Compensation Act of 1990, as amended. (a) Compensation. (1) A radiation-exposed veteran, as defined in 38 CFR 3.309(d)(3), who receives a payment under the...

String test

MedlinePlus

... Management by Laboratory Methods . 23rd ed. Philadelphia, PA: Elsevier; 2017:chap 64. Bope ET, Kellerman RD. The ... ET, ed. Conn's Current Therapy 2016 . Philadelphia, PA: Elsevier; 2016:chap 3. Haines CF, Sears CL. Infectious ...

TUDCA Slows Retinal Degeneration in Two Different Mouse Models of Retinitis Pigmentosa and Prevents Obesity in Bardet-Biedl Syndrome Type 1 Mice

PubMed Central

Drack, Arlene V.; Dumitrescu, Alina V.; Bhattarai, Sajag; Gratie, Daniel; Stone, Edwin M.; Mullins, Robert

2012-01-01

Purpose. To evaluate and compare the protective effect of tauroursodeoxycholic acid (TUDCA) on photoreceptor degeneration in different models of retinal degeneration (RD) in mice. Methods. BbsM390R/M390R mice were injected subcutaneously twice a week, from P40 to P120, and rd10 mice were injected every 3 days from P6 to P38 with TUDCA or vehicle (0.15 M NaHCO3). Rd1 and rd16 mice were injected daily from P6 to P30 with TUDCA or vehicle. Retinal structure and function were determined at multiple time points by electroretinography (ERG), optical coherence tomography (OCT), and histology. Results. The amplitude of ERG b-waves was significantly higher in TUDCA-treated Bbs1 and rd10 animals than in controls. Retinal thickness on OCT was slightly greater in treated Bbs1 animals than in the controls. Histologically, outer segments were preserved, and the outer nuclear layer was significantly thicker in the treated Bbs1 and rd10 mice than in the controls. Bbs1M390R/M390R mice developed less obesity than the control Bbs1M390R/M390R while receiving TUDCA. The Rd1 and rd16 mice showed no improvement with TUDCA treatment, and the rd1 mice did not have normal weight gain during treatment. Conclusions. TUDCA treatment preserved ERG b-waves and the outer nuclear layer in Bbs1M390R/M390R mice, and prevented obesity assessed at P120. TUDCA treatment preserved ERG b-waves and the outer nuclear layer in the rd10 mice to P30. TUDCA is a prime candidate for treatment of humans with retinal degeneration, especially those with Bardet-Biedl syndrome, whom it may help not only with the vision loss, but with the debilitating obesity as well. PMID:22110077

Edaravone, an ROS Scavenger, Ameliorates Photoreceptor Cell Death after Experimental Retinal Detachment

PubMed Central

Roh, Mi In; Murakami, Yusuke; Thanos, Aristomenis; Miller, Joan W.

2011-01-01

Purpose. To investigate whether edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a free radical scavenger, would be neuroprotective against photoreceptor cell death in a rat model of retinal detachment (RD). Methods. RD was induced in adult Brown Norway rats by subretinal injection of sodium hyaluronate. Edaravone (3, 5, or 10 mg/kg) or physiologic saline was administered intraperitoneally once a day until death on day 3 or 5. Oxidative stress in the retina was assessed by 4-hydroxynonenal staining or ELISA for protein carbonyl content. Photoreceptor death was assessed by TUNEL and measurement of the outer nuclear layer thickness. Western blot analysis and caspase activity assays were performed. Inflammatory cytokine secretion and inflammatory cell infiltration were evaluated by ELISA and immunostaining, respectively. Results. RD resulted in increased generation of ROS. Treatment with 5 mg/kg edaravone significantly reduced the ROS level, along with a decrease in TUNEL-positive cells in the photoreceptor layer. A caspase assay also confirmed decreased activation of caspase-3, -8, and -9 in RD treated with edaravone. The level of the antiapoptotic Bcl-2 was increased in detached retinas after edaravone treatment, whereas the levels of the stress-activated p-ERK1/2 were decreased. In addition, edaravone treatment resulted in a significant decrease in the levels of TNF-α, MCP-1, and macrophage infiltration. Conclusions. Oxidative stress plays an important role in photoreceptor cell death after RD. Edaravone treatment may aid in preventing photoreceptor cell death after RD by suppressing ROS-induced photoreceptor damage. PMID:21310909

Structural development of human brain white matter from mid-fetal to perinatal stage

NASA Astrophysics Data System (ADS)

Ouyang, Austin; Yu, Qiaowen; Mishra, Virendra; Chalak, Lina; Jeon, Tina; Sivarajan, Muraleedharan; Jackson, Greg; Rollins, Nancy; Liu, Shuwei; Huang, Hao

2015-03-01

The structures of developing human brain white matter (WM) tracts can be effectively quantified by DTI-derived metrics, including fractional anisotropy (FA), mean, axial and radial diffusivity (MD, AD and RD). However, dynamics of WM microstructure during very early developmental period from mid-fetal to perinatal stage is unknown. It is difficult to accurately measure microstructural properties of these WM tracts due to severe contamination from cerebrospinal fluid (CSF). In this study, high resolution DTI of fetal brains at mid-fetal stage (20 weeks of gestation or 20wg), 19 brains in the middle of 3rd trimester (35wg) and 17 brains around term (40wg) were acquired. We established first population-averaged DTI templates at these three time points and extracted WM skeleton. 16 major WM tracts in limbic, projection, commissural and association tract groups were traced with DTI tractography in native space. The WM skeleton in the template space was inversely transformed back to the native space for measuring core WM microstructures of each individual tract. Continuous microstructural enhancement and volumetric increase of WM tracts were found from 20wg to 40wg. The microstructural enhancement from FA measurement is decelerated in late 3rd trimester compared to mid-fetal to middle 3rd trimester, while volumetric increase of prefrontal WM tracts is accelerated. The microstructural enhancement from 35wg to 40wg is heterogeneous among different tract groups with microstructures of association tracts undergoing most dramatic change. Besides decreases of RD indicating active myelination, the decrease of AD for most WM tracts during late 3rd trimester suggests axonal packing process.

Mortality in bullous pemphigoid and prognostic factors in 1st and 3rd year of follow-up in specialized centre in Poland.

PubMed

Kalinska-Bienias, Agnieszka; Lukowska-Smorawska, Katarzyna; Jagielski, Pawel; Kowalewski, Cezary; Wozniak, Katarzyna

2017-11-01

Bullous pemphigoid (BP) is associated with higher mortality and coexisting comorbidities, some of them affecting poor prognosis. The aim of the study was to identify prognostic factors causing greater mortality both in the 1st and 3rd year of follow-up and to determine the 1-, 2-, 3-year mortality rates, standardized mortality ratio (SMR) in Polish BP patients. All patients with BP (a cohort of 205 patients, mean age 76.2 years) diagnosed between 5 January 2000 and 10 December 2013 in a referral unit for autoimmune bullous diseases at the university hospital in Poland were included retrospectively. Mortality data were obtained from the Centre for Document Personalization at the Minister of Interior and Administration. Our original observation was that prednisone in moderate dose (0.5 mg kg -1 ) in monotherapy was an independent risk factor of fatal prognosis in the 1st year of follow-up, assessed using multivariate analysis. We confirmed the strong correlation between neurological diseases and greater mortality. Both in the 1st and 3rd year of follow-up, dementia and Parkinson disease resulted in increased mortality. We also found that arrhythmias significantly increased mortality in the 1st and 3rd year of follow-up. The prognostic factors in BP changed over time of follow-up. In the 3rd year of observation, the age above 77, longer hospitalization and BP severity were associated with greater mortality. We observed poorer prognosis in BP patients than age-matched general Polish population. The 1-, 2-, 3-year mortality rates were 22.4, 31.2, 39.5% and SMR was 3.8 (95% CI 3.4-3.7).

Biochar Addition Increases the Rates of Dissimilatory Iron Reduction and Methanogenesis in Ferrihydrite Enrichments

PubMed Central

Zhou, Guo-Wei; Yang, Xiao-Ru; Marshall, Christopher W.; Li, Hu; Zheng, Bang-Xiao; Yan, Yu; Su, Jian-Qiang; Zhu, Yong-Guan

2017-01-01

Biochar contains quinones and aromatic structures that facilitate extracellular electron transfer between microbial cells and insoluble minerals. In this study, granulated biochar (1.2–2 mm) and powdered biochar (<0.15 mm) were amended to two ferrihydrite (in situ ferrihydrite and ex situ ferrihydrite) enrichments to investigate the effect of biochar with different particle sizes on dissimilatory iron(III)-reducing bacteria (DIRB) and methanogens. Biochar addition significantly stimulated the reduction of both in situ ferrihydrite and ex situ ferrihydrite and the production of methane. Powdered biochar amendments increased iron reduction compared to granulated biochar amendment in both the in situ ferrihydrite and ex situ ferrihydrite enrichments. However, no significant difference was observed in methane production between the powdered biochar and granulated biochar amendments in the two ferrihydrite enrichments. Analysis of 16S rRNA gene sequences showed that both DIRB and methanogens were enriched after biochar amendments in the in situ ferrihydrite and ex situ ferrihydrite enrichments. Taxa belonging to the Geobacteraceae and methanogenic genus affiliated to Methanosarcina were detected with significantly higher relative abundances in powdered biochar amendments than those in granulated biochar amendments in both the ferrihydrite enrichments. X-ray diffraction analysis indicated green rust [Fe2(CO3) (OH)] and vivianite [Fe3(PO4)2 8(H2O)] formed in the ex situ ferrihydrite and in situ ferrihydrite enrichments without biochar addition, respectively. After granulated biochar amendment, the mineral phase changed from the green rust to vivianite in the ex situ ferrihydrite enrichment, while crystalline vivianite and iron oxide (γ-Fe2O3) were detected simultaneously in the in situ ferrihydrite enrichment. No crystalline iron compound was found in the powdered biochar amendments in both ferrihydrite enrichments. Overall, our study illustrated that the addition of biochar affected iron-reducing and methane-generating microbial communities to some extent. PMID:28428774

Establishment of reference values in a healthy population and interpretation of serum PTH concentrations in hemodialyzed patients according to the KDIGO Guidelines using the Lumipulse® G whole PTH (3rd generation) assay.

PubMed

Cavalier, Etienne; Salsé, Margot; Dupuy, Anne-Marie; Bargnoux, Anne-Sophie; Watar, Florence; Souberbielle, Jean-Claude; Delanaye, Pierre; Cristol, Jean-Paul

2018-04-01

3rd generation PTH assays only detect the bioactive 1-84 fragment. Since standardization is still lacking, each new PTH assay requires to establish reference values and to assess the impact in the medical care of the mineral and bone disorders in hemodialyzed patients. Using Fujirebio Lumipulse G wPTH assay, serum PTH levels were measured in a population of 439 healthy subjects from France and Belgium PTH levels were also determined in 119 hemodialyzed patients. These patients were classified according to the KDIGO recommendation. Reference range was found to be 6.5 (90%CI: 6.0-7.0) - 41.8 (90% CI: 38.1-43.7). In hemodialysis patients, Passing-Bablock regression between 3rd generation PTH from Fujirebio and DiaSorin was DiaSorin = 1.01 xFujirebio-2.4 with a slope not different from 1.0(95%CI: 0.96-1.04) and a non-significant intercept, ranging from -6.0 to 0.1. Hemodialysis patients with a PTH concentration below 2-fold the Upper Limit of Normality (ULN), within the KDIGO range and upper 9-fold upper limit were respectively 33.6%, 54.6%, 11.8% (Fujirebio Lumipulse) and 36.1%, 51.3% and 12.6% (Diasorin Liaison). We determined a reference range with the 3rd generation PTH assay from Fujirebio. In a hemodialysis population, 3rd generation assays from Fujirebio and DiaSorin provide similar results. To the best of our knowledge, this is the first time that we can show similar PTH results obtained by 2 different 3rd generation PTH assays in healthy subjects and hemodialyzed patients without mathematically processing them. Copyright © 2018 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Pooled nucleic acid testing increases the diagnostic yield of acute HIV infections in a high-risk population compared to 3rd and 4th generation HIV enzyme immunoassays.

PubMed

Krajden, Mel; Cook, Darrel; Mak, Annie; Chu, Ken; Chahil, Navdeep; Steinberg, Malcolm; Rekart, Michael; Gilbert, Mark

2014-09-01

We compared a 3rd generation (gen) and two 4th gen HIV enzyme immunoassays (EIA) to pooled nucleic acid testing (PNAT) for the identification of pre- and early seroconversion acute HIV infection (AHI). 9550 specimens from males >18 year from clinics attended by men who have sex with men were tested by Siemens ADVIA Centaur(®) HIV 1/O/2 (3rd gen) and HIV Combo (4th gen), as well as by Abbott ARCHITECT(®) HIV Ag/Ab Combo (4th gen). Third gen non-reactive specimens were also tested by Roche COBAS(®) Ampliprep/COBAS® TaqMan HIV-1 Test v.2 in pools of 24 samples. Sensitivity and specificity of the three EIAs for AHI detection were compared. 7348 persons contributed 9435 specimens and had no evidence of HIV infection, 79 (94 specimens) had established HIV infection, 6 (9 specimens) had pre-seroconversion AHI and 9 (12 specimens) had early seroconversion AHI. Pre-seroconversion AHI cases were not detected by 3rd gen EIA, whereas 2/6 (33.3%) were detected by Siemens 4th gen, 4/6 (66.7%) by Abbott 4th gen and 6/6 (100%) by PNAT. All three EIAs and PNAT detected all individuals with early seroconversion AHI. Overall sensitivity/specificity for the EIAs relative to WB or NAT resolved infection status was 93.6%/99.9% for Siemens 3rd gen, 95.7%/99.7% for Siemens 4th gen and 97.9%/99.2% for Abbott 4th gen. While both 4th gen EIAs demonstrated improved sensitivity for AHI compared to 3rd gen EIA, PNAT identified more AHI cases than either 4th gen assay. PNAT is likely to remain a useful strategy to identify AHI in high-risk populations. Copyright © 2014 Elsevier B.V. All rights reserved.

Crop Rotation and Races of Meloidogyne incognita in Cotton Root-knot Management

PubMed Central

Kirkpatrick, T. L.; Sasser, J. N.

1984-01-01

The influence o f various crop rotations and nematode inoculum levels on subsequent population densities of Meloidogyne incognita races 1 and 3 were studied in microplots. Ten different 3-year sequences o f cotton, corn, peanut, or soybean, all with cotton as the 3rd-year crop, were grown in microplots infested with each race. Cotton monoculture, two seasons o f corn, or cotton followed by corn resulted in high race 3 population densities and severe root galling on cotton the 3rd year. Peanut for 2 years preceding cotton most effectively decreased the race 3 population and root galls on cotton the 3rd year. Race 1 did not significantly influence cotton growth or yield at initial populations of up to 5,000 eggs/500 cm³ soil. At 5,000 eggs/500 cm³, cotton growth was suppressed by race 3 but yield was not affected. PMID:19294030

RNA-dependent RNA polymerase of hepatitis C virus binds to its coding region RNA stem-loop structure, 5BSL3.2, and its negative strand.

PubMed

Kanamori, Hiroshi; Yuhashi, Kazuhito; Ohnishi, Shin; Koike, Kazuhiko; Kodama, Tatsuhiko

2010-05-01

The hepatitis C virus NS5B RNA-dependent RNA polymerase (RdRp) is a key enzyme involved in viral replication. Interaction between NS5B RdRp and the viral RNA sequence is likely to be an important step in viral RNA replication. The C-terminal half of the NS5B-coding sequence, which contains the important cis-acting replication element, has been identified as an NS5B-binding sequence. In the present study, we confirm the specific binding of NS5B to one of the RNA stem-loop structures in the region, 5BSL3.2. In addition, we show that NS5B binds to the complementary strand of 5BSL3.2 (5BSL3.2N). The bulge structure of 5BSL3.2N was shown to be indispensable for tight binding to NS5B. In vitro RdRp activity was inhibited by 5BSL3.2N, indicating the importance of the RNA element in the polymerization by RdRp. These results suggest the involvement of the RNA stem-loop structure of the negative strand in the replication process.

Generation of 1.3 μm and 1.5 μm high-energy Raman radiations in α-BaTeMo2O9 crystals

NASA Astrophysics Data System (ADS)

Liu, Shande; Zhang, Junjie; Gao, Zeliang; Wei, Lei; Zhang, Shaojun; He, Jingliang; Tao, Xutang

2014-02-01

The generations of high energy 2nd- and 3rd-order stimulated Raman scattering lasers based on the α-BaTeMo2O9 crystal were demonstrated for the first time. The Raman gain coefficient has been compared with that of the YVO4 crystal. A maximum total Stokes radiation energy of 27.3 mJ was obtained, containing 20.1 mJ 2nd-order Stokes energy at 1318 nm, together with 7.2 mJ 3rd-order Stokes energy at 1497 nm, giving an overall conversion efficiency of 35.9% and a slope efficiency of 54.5%. With an optical coating design, a total 3rd- and 4th-order Stokes energy of 16.5 mJ was generated. The maximum energy for 4th-order Stokes radiation at 1731 nm was 2 mJ. The pulse durations for the 2nd-, 3rd-, and 4th-order Stokes shift were 10 ns, 8.6 ns, and 5.2 ns, respectively. Our experimental results show that the α-BTM crystal is a promising Raman crystal for the generations of eye-safe radiations.

75 FR 24820 - Federal Management Regulation; Replacement of Personal Property Pursuant to the Exchange/Sale...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-06

... of damage caused by, for example, natural disaster or accident, should also be eligible for exchange... natural disaster); or (3) Scrap gold for fine gold. * * * * * Sec. 102-39.80 [Amended] 0 3. Amend Sec. 102...

State Agency R&D Activities Almost Quadrupled From FY 1964 to FY 1973. Science Resources Studies Highlights. September 3, 1974.

ERIC Educational Resources Information Center

National Science Foundation, Washington, DC. Div. of Science Resources Studies.

This bulletin presents data from a survey covering research and development (R&D) expenditures of state government agencies (exclusive of state universities and colleges) for 1973. Charts showing expenditures, by source of funds of selected years and share of character-of-work components in state agency R&D activities, are shown in the report.…

Early Response-to-Intervention Measures and Criteria as Predictors of Reading Disability in 3rd Grade

ERIC Educational Resources Information Center

Beach, Kristen Dawn

2012-01-01

Reading is the most valuable skill children must master early in schooling. Unfortunately, many students struggle to read and may be identified as having a Reading Disability (RD). In this dissertation, I explored the usefulness of the Response-to-Intervention (RtI) framework for identifying children with RD by examining the use of 1st and 2nd…

Tracking Children Who Fly below the Radar: Latent Transition Modeling of Students with Late-Emerging Reading Disability

ERIC Educational Resources Information Center

Compton, Donald L.; Fuchs, Douglas; Fuchs, Lynn S.; Elleman, Amy M.; Gilbert, Jennifer K.

2008-01-01

The purpose of this study was to examine (1) the stability of latent classes associated with reading disability (RD) and typical development (TD) across time, (2) the importance of speeded word recognition as a latent class indicator of RD and TD, and (3) possible early indicators of students with late-emerging RD. Analyses were based on a…

Tissue inhibitor of metalloproteinases 1 enhances rod survival in the rd1 mouse retina.

PubMed

Kim, Hwa Sun; Vargas, Andrew; Eom, Yun Sung; Li, Justin; Yamamoto, Kyra L; Craft, Cheryl Mae; Lee, Eun-Jin

2018-01-01

Retinitis pigmentosa (RP), an inherited retinal degenerative disease, is characterized by a progressive loss of rod photoreceptors followed by loss of cone photoreceptors. Previously, when tissue inhibitor of metalloproteinase 1 (TIMP1), a key extracellular matrix (ECM) regulator that binds to and inhibits activation of Matrix metallopeptidase 9 (MMP9) was intravitreal injected into eyes of a transgenic rhodopsin rat model of RP, S334ter-line3, we discovered cone outer segments are partially protected. In parallel, we reported that a specific MMP9 and MMP2 inhibitor, SB-3CT, interferes with mechanisms leading to rod photoreceptor cell death in an MMP9 dependent manner. Here, we extend our initial rat studies to examine the potential of TIMP1 as a treatment in retinal degeneration by investigating neuroprotective effects in a classic mouse retinal degeneration model, rdPde6b-/- (rd1). The results clearly demonstrate that intravitreal injections of TIMP1 produce extended protection to delay rod photoreceptor cell death. The mean total number of rods in whole-mount retinas was significantly greater in TIMP-treated rd1 retinas (postnatal (P) 30, P35 (P<0.0001) and P45 (P<0.05) than in saline-treated rd1 retinas. In contrast, SB-3CT did not delay rod cell death, leading us to further investigate alternative pathways that do not involve MMPs. In addition to inducing phosphorylated ERK1/2, TIMP1 significantly reduces BAX activity and delays attenuation of the outer nuclear layer (ONL). Physiological responses using scotopic electroretinograms (ERG) reveal b-wave amplitudes from TIMP1-treated retinas are significantly greater than from saline-treated rd1 retinas (P<0.05). In later degenerative stages of rd1 retinas, photopic b-wave amplitudes from TIMP1-treated rd1 retinas are significantly larger than from saline-treated rd1 retinas (P<0.05). Our findings demonstrate that TIMP1 delays photoreceptor cell death. Furthermore, this study provides new insights into how TIMP1 works in the mouse animal model of RP.

77 FR 71813 - Connecticut; Amendment No. 3 to Notice of a Major Disaster Declaration

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-04

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Internal Agency Docket No. FEMA-4087-DR; Docket ID FEMA-2012-0002] Connecticut; Amendment No. 3 to Notice of a Major Disaster..., Administrator, Federal Emergency Management Agency. [FR Doc. 2012-29207 Filed 12-3-12; 8:45 am] BILLING CODE...

30 CFR 950.15 - Approval of Wyoming regulatory program amendments.

Code of Federal Regulations, 2010 CFR

2010-07-01

...), (ba), 3(b)(i); Ch II, §§ 3(a)(vi)(E), (M), (b)(xvi)(D), (xx), (v)(C); Ch IV, §§ 3(d)(vii), (e)(i)(H..., 2009 Chapter 11, Section 2(a)(vii)(A). [62 FR 9958, Mar. 5, 1997, as amended at 64 FR 53208, Oct. 1...

78 FR 74121 - Office of the Secretary

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-10

..., CO 80011- 9066. FOR FURTHER INFORMATION CONTACT: Elan Green, Medical Benefits and Reimbursement... Care Act (PPACA) which amended section 1886(b)(3)(B) of the Social Security Act, and (2) a 0.3 percent point adjustment as required by section 1886(b)(3)(B)(xii) of the Act as added and amended by sections...

Effects of organic amendment on degradation of 1,3-dichloropropene and chloropicrin in soil

USDA-ARS?s Scientific Manuscript database

Soil fumigants 1,3-dichloropropene (1,3-D) and chloropicrin (CP), are promising alternatives to the phased-out methyl bromide. However, these fumigants are volatile organic compounds and contribute to air pollution from emissions. Organic amendment to soils has been found to reduce emissions by incr...

Primary care characteristics and stage of cancer at diagnosis using data from the national cancer registration service, quality outcomes framework and general practice information.

PubMed

Maclean, Rebecca; Jeffreys, Mona; Ives, Alex; Jones, Tim; Verne, Julia; Ben-Shlomo, Yoav

2015-07-05

Survival from cancer is worse in England than in some European countries. To improve survival, strategies in England have focused on early presentation (reducing delay to improve stage at diagnosis), improving quality of care and ensuring equity throughout the patient pathway. We assessed whether primary care characteristics were associated with later stage cancer at diagnosis (stages 3/4 versus 1/2) for female breast, lung, colorectal and prostate cancer. Data obtained from the National Cancer Registration Service, Quality Outcomes Framework, GP survey and GP workforce census, linked by practice code. Risk differences (RD) were calculated by primary care characteristics using a generalised linear model, accounting for patient clustering within practices. Models were adjusted for age, sex and an area-based deprivation measure. For female breast cancer, being with a practice with a higher two week wait (TWW) referral rate (RD -1.8% (95 % CI -0.5% to -3.2%) p = 0.003) and a higher TWW detection rate (RD -1.7% (95 % CI -0.3% to -3.0%) p = 0.003) was associated with a lower proportion diagnosed later. Being at a practice where people thought it less easy to book at appointment was associated with a higher percentage diagnosed later (RD 1.8% (95 % CI 0.2% to 3.4%) p = 0.03). For lung cancer, being at practices with higher TWW referral rates was associated with lower proportion advanced (RD-3.6% (95 % CI -1.8%, -5.5%) p < 0.001) whereas being at practices with more patients per GP was associated with higher proportion advanced (RD1.8% (95 % CI 0.2, 3.4) p = 0.01). A higher rate of gastrointestinal investigations was associated with a lower proportion of later stage colorectal cancers (RD -2.0% (95 % CI -0.6% to -3.6%) p = 0.01). No organisational characteristics were associated with prostate cancer stage. Easier access to primary care, faster referral and more investigation for gastrointestinal symptoms could reduce the proportion of people diagnosed later for female breast, lung and colorectal, but not prostate cancer. Differences between the four main cancers suggest different policies may be required for individual cancers to improve outcomes.

A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability and de Novo Initiation Activities*

PubMed Central

Lim, Siew Pheng; Koh, Jolene Hong Kiew; Seh, Cheah Chen; Liew, Chong Wai; Davidson, Andrew D.; Chua, Leng Shiew; Chandrasekaran, Ramya; Cornvik, Tobias C.; Shi, Pei-Yong; Lescar, Julien

2013-01-01

The dengue virus (DENV) non-structural protein 5 (NS5) comprises an N-terminal methyltransferase and a C-terminal RNA-dependent RNA polymerase (RdRp) domain. Both enzymatic activities form attractive targets for antiviral development. Available crystal structures of NS5 fragments indicate that residues 263–271 (using the DENV serotype 3 numbering) located between the two globular domains of NS5 could be flexible. We observed that the addition of linker residues to the N-terminal end of the DENV RdRp core domain stabilizes DENV1–4 proteins and improves their de novo polymerase initiation activities by enhancing the turnover of the RNA and NTP substrates. Mutation studies of linker residues also indicate their importance for viral replication. We report the structure at 2.6-Å resolution of an RdRp fragment from DENV3 spanning residues 265–900 that has enhanced catalytic properties compared with the RdRp fragment (residues 272–900) reported previously. This new orthorhombic crystal form (space group P21212) comprises two polymerases molecules arranged as a dimer around a non-crystallographic dyad. The enzyme adopts a closed “preinitiation” conformation similar to the one that was captured previously in space group C2221 with one molecule per asymmetric unit. The structure reveals that residues 269–271 interact with the RdRp domain and suggests that residues 263–268 of the NS5 protein from DENV3 are the major contributors to the flexibility between its methyltransferase and RdRp domains. Together, these results should inform the screening and development of antiviral inhibitors directed against the DENV RdRp. PMID:24025331

Reduced Rapid Eye Movement Density in Parkinson Disease: A Polysomnography-Based Case-Control Study.

PubMed

Schroeder, Lynn A; Rufra, Olivier; Sauvageot, Nicolas; Fays, François; Pieri, Vannina; Diederich, Nico J

2016-12-01

To explore rapid eye movement density (RD) in patients with idiopathic Parkinson disease (IPD) and to investigate its usefulness as surrogate marker of excessive daytime sleepiness, a frequent complaint in IPD patients. Retrospective polysomnography study on 81 subjects without dementia: 29 patients with early stage IPD (disease duration ≤ 3 y), 21 patients with middle- stage IPD (disease duration > 3 and < 8 y) and 31 healthy controls (HC). Rapid eye movement (REM) sleep was defined as any REM episode with > 3 min of continuous REM sleep. RD was defined as number of ocular movements per minute of REM sleep. Patients with early stage IPD and HC fulfilled the PD-specific sleepiness questionnaires Parkinson's Disease Sleep Scale (PDSS) and the Nonmotor Symptoms Questionnaire for Parkinson's disease (NMSQuest). RD was lower in patients with IPD than in HC. The difference was most significant between patients with middle stage IPD and HC (P = 0.001), and most prominent for the third REM episode, again when comparing patients with middle stage IPD and HC (P = 0.03). RD was independent from sex, age, and other sleep parameters. In early stage IPD, RD correlated with the PDSS score (r = -0.63, P = 0.001) and the sleep-related questions of the NMSQuest score (r = 0.48, P = 0.017). REM density is reduced in patients with IPD and correlates with subjective scores on sleep impairment. As an indicator of persistent high sleep pressure, reduced RD in IPD is eligible as a biomarker of excessive daytime sleepiness in IPD. It possibly reflects direct involvement of the brainstem REM generation sites by the disease process. RD is a promising new tool for sleep research in IPD. © 2016 Associated Professional Sleep Societies, LLC.

75 FR 79368 - Tetrahydro-3, 5-dimethyl-2H-1, 3, 4-thiadiazine-2-thione; Amendment To Terminate and or Delete...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-20

...This notice announces EPA's order for the amendment to terminate and/or delete certain uses, voluntarily requested by the registrant and accepted by the Agency, of the products, listed in Table 1, pursuant to section 6(f)(1) of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), as amended. This order follows a September 10, 2010 Federal Register Notice of Receipt of Request from the registrant listed in Table 2 to voluntarily amend their tetrahydro-3, 5-dimethyl-2H-1, 3, 4-thiadiazine-2-thione (Dazomet) product registrations to terminate or delete one or more uses. The request would terminate the uses listed in Table 1 of Unit II. The request would delete the uses listed in Table 2 of Unit II. The request would not terminate the last tetrahydro-3, 5-dimethyl-2H-1, 3, 4-thiadiazine- 2-thione products registered for use in the United States and would result in retention of some registered uses for those products. In the September 10, 2010 notice, EPA indicated that it would issue an order implementing the amendments to terminate uses, unless the Agency received substantive comments within the 30-day comment period that would merit its further review of these requests, or unless the registrant withdrew their request within this period. The Agency did not receive any comments on the notice. Further, the registrant did not withdraw their request. Accordingly, EPA hereby issues in this notice a cancellation order granting the requested amendment to terminate uses. Any distribution, sale, or use of the products subject to this cancellation order is permitted only in accordance with the terms of this order, including any existing stocks provisions.

RNA content in spinal cord motoneurons during hypokinesia

NASA Technical Reports Server (NTRS)

Gorbunova, A. V.

1980-01-01

The effect of a diminished motor activity of rats upon the ribonucleic and (RNA) content in a single isolated motoneuron of frontal of their spinal cord was studied. Within a 1 to 30 day exposure of rats to the hypokinetic conditions, RNA content was found to decrease on the 1st, 3rd, and 5th day and to return to the initial level by the 7th day. No changes in RNA content were observed during the subsequent stages of the xperiments. The volume of the nerve cells declined on the 3rd and 5th day, whereas RNA concentration reduced on the 1st, 3rd, 5th, and 30th day.

3rd Interplanetary Network Gamma-Ray Burst Website

NASA Astrophysics Data System (ADS)

Hurley, Kevin

1998-05-01

We announce the opening of the 3rd Interplanetary Network web site at http://ssl.berkeley.edu/ipn3/index.html This site presently has four parts: 1. A bibliography of over 3000 publications on gamma-ray bursts, 2. IPN data on all bursts triangulated up to February 1998, 3. A master list showing which spacecraft observed which bursts, 4. Preliminary IPN data on the latest bursts observed.

15 CFR Supplement No. 7 to Part 748 - Authorization Validated End-User (VEU): List of Validated End-Users, Respective Items Eligible...

Code of Federal Regulations, 2010 CFR

2010-01-01

...; 2B230; 2B350.d.2 2B350.g.3 2B350.i.4; 3B001.c.2; 3C002; 3C004 Headquarters and Fab. 1 of HHNEC, No. 1188 Chuan Qiao Rd., Pu Dong, Shanghai, China 201206.Fab. 2 of HHNEC, No. 668 Guo Shou Jing Rd., Zhang Jiang...

Structure–Activity Relationships for a Novel Series of Dopamine D2-like Receptor Ligands Based on N-Substituted 3-Aryl-8-azabicyclo[3.2.1]octan-3-ol

PubMed Central

Paul, Noel M.; Taylor, Michelle; Kumar, Rakesh; Deschamps, Jeffrey R.; Luedtke, Robert R.; Newman, Amy Hauck

2011-01-01

Discovering dopamine D2-like receptor subtype-selective ligands has been a focus of significant investigation. The D2R-selective antagonist 3-[4-(4-chlorophenyl)-4-hydroxypiperidinyl]methylindole (1, L741,626; Ki(D2R/D3R) = 11.2:163 nM) has previously provided a lead template for chemical modification. Herein, analogues have been synthesized where the piperidine was replaced by a tropane ring that reversed the selectivity seen in the parent compound, in human hD2LR- or hD3R-transfected HEK 293 cells (31, Ki(D2R/D3R) = 33.4: 15.5 nM). Further exploration of both N-substituted and aryl ring-substituted analogues resulted in the discovery of several high affinity D2R/D3R ligands with 3-benzofurylmethyl-substituents (e.g., 45, Ki(D2R/D3R) = 1.7:0.34 nM) that induced high affinity not achieved in similarly N-substituted piperidine analogues and significantly (470-fold) improved D3R binding affinity compared to the parent ligand 1. X-ray crystallographic data revealed a distinctive spatial arrangement of pharmacophoric elements in the piperidinol vs tropine analogues, providing clues for the diversity in SAR at the D2 and D3 receptor subtypes. PMID:18774793

United Kingdom National Ophthalmology Database study of vitreoretinal surgery: report 3, retinal detachment.

PubMed

Jackson, Timothy L; Donachie, Paul H J; Sallam, Ahmed; Sparrow, John M; Johnston, Robert L

2014-03-01

To describe rhegmatogenous retinal detachment (RD) surgery. National Ophthalmology Database study. A total of 3403 eyes from 3321 patients undergoing primary RD surgery. Participating centers prospectively collected clinical data using a single electronic medical record system, with automatic extraction of anonymized data to a national database, from 2002 to 2010. Description of the primary procedures performed, intraoperative complication rate, and proportion of eyes undergoing subsequent RD or cataract surgery. We undertook an exploratory analysis of change in visual acuity (VA) using the data available. Of 3403 operations, 2693 (79.1%) were pars plana vitrectomy (PPV), 413 (12.1%) were retinopexy with a scleral buckle (SB), and 297 (8.7%) were PPV with an SB (PPV-SB). For PPV and PPV-SB, 18.8% were with hexafluoroethane, 12.1% were with perfluoropropane, 43.1% were with sulfahexafluoride, 1.8% were with air, 17.9% were with silicone oil, and 10.7% were with cataract surgery. Within 1 year of vitrectomy, 52.1% of phakic eyes had undergone cataract surgery. For all RD operations combined (and excluding cataract surgery complications), 5.1% had 1 or more intraoperative complication, 13.0% underwent further RD surgery, and 8.3% had silicone oil in situ at last review. The RD reoperation rate was 13.3%, 12.3%, and 14.5% for PPV, SB, and PPV-SB, respectively. For 961 eyes with a baseline and final VA measurement, the median presenting logarithm of the minimum angle of resolution VA improved from 1.0 to 0.5 (20/200-20/63) after a median follow-up of 0.6 years. These results may help vitreoretinal surgeons to benchmark their intraoperative complication rate and reoperation rate and to compare their surgical techniques with their peers'. They suggest that the benefits of RD surgery greatly outweigh the risks. Copyright © 2014 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

30 CFR 931.25 - Approval of New Mexico abandoned mine land reclamation plan amendments.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Approval of New Mexico abandoned mine land reclamation plan amendments. 931.25 Section 931.25 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND... STATE NEW MEXICO § 931.25 Approval of New Mexico abandoned mine land reclamation plan amendments. The...

75 FR 13755 - Freeport LNG Development, L.P.; Application To Amend Blanket Authorization To Export Liquefied...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-23

... Amend Blanket Authorization To Export Liquefied Natural Gas AGENCY: Office of Fossil Energy, DOE. ACTION: Notice of Application to Amend Blanket Authorization. SUMMARY: The Office of Fossil Energy (FE) of the... Oil and Gas Global Security and Supply, Office of Fossil Energy, Forrestal Building, Room 3E-042, 1000...

36 CFR 903.8 - Review of request for amendment of record.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Review of request for amendment of record. 903.8 Section 903.8 Parks, Forests, and Public Property PENNSYLVANIA AVENUE DEVELOPMENT CORPORATION PRIVACY ACT § 903.8 Review of request for amendment of record. (a) Upon receipt of a request for...

Prisoners' First Amendment Rights Within the Institution. Criminal Justice Monograph. Volume III, No. 3.

ERIC Educational Resources Information Center

Sanders, Rabun C., Jr.; And Others

This monograph examines prisoners' rights to freedom of speech, religion, and petition under the First Amendment to the United States Constitution. The courts had previously taken the attitude that the operation of penal institutions was beyond their jurisdiction, but the suppression of and restrictions on the exercise of first amendment freedoms…

20 CFR 655.35 - Amendments to an application or job order.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 3 2014-04-01 2014-04-01 false Amendments to an application or job order... Amendments to an application or job order. (a) Increases in number of workers. The employer may request to... into account the effect of the changes on the underlying labor market test for the job opportunity...

20 CFR 655.35 - Amendments to an application or job order.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 20 Employees' Benefits 3 2013-04-01 2013-04-01 false Amendments to an application or job order... Amendments to an application or job order. (a) Increases in number of workers. The employer may request to... into account the effect of the changes on the underlying labor market test for the job opportunity...

30 CFR 931.25 - Approval of New Mexico abandoned mine land reclamation plan amendments.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Approval of New Mexico abandoned mine land reclamation plan amendments. 931.25 Section 931.25 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND... STATE NEW MEXICO § 931.25 Approval of New Mexico abandoned mine land reclamation plan amendments. The...

30 CFR 931.25 - Approval of New Mexico abandoned mine land reclamation plan amendments.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Approval of New Mexico abandoned mine land reclamation plan amendments. 931.25 Section 931.25 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND... STATE NEW MEXICO § 931.25 Approval of New Mexico abandoned mine land reclamation plan amendments. The...

30 CFR 931.25 - Approval of New Mexico abandoned mine land reclamation plan amendments.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Approval of New Mexico abandoned mine land reclamation plan amendments. 931.25 Section 931.25 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND... STATE NEW MEXICO § 931.25 Approval of New Mexico abandoned mine land reclamation plan amendments. The...

30 CFR 931.25 - Approval of New Mexico abandoned mine land reclamation plan amendments.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Approval of New Mexico abandoned mine land reclamation plan amendments. 931.25 Section 931.25 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND... STATE NEW MEXICO § 931.25 Approval of New Mexico abandoned mine land reclamation plan amendments. The...

17 CFR 230.486 - Effective date of post-effective amendments and registration statements filed by certain closed...

Code of Federal Regulations, 2014 CFR

2014-04-01

... 17 Commodity and Securities Exchanges 3 2014-04-01 2014-04-01 false Effective date of post....486 Effective date of post-effective amendments and registration statements filed by certain closed... section, a post-effective amendment to a registration statement, or a registration statement filed for the...

15 CFR 714.4 - Amended declaration or report.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS § 714.4 Amended declaration or report. In order for BIS to maintain... following information that you have previously declared or reported: (1) Types of Schedule 3 chemicals...

15 CFR 714.4 - Amended declaration or report.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS § 714.4 Amended declaration or report. In order for BIS to maintain... following information that you have previously declared or reported: (1) Types of Schedule 3 chemicals...

Toy Talk: Simple Strategies to Create Richer Grammatical Input

ERIC Educational Resources Information Center

Hadley, Pamela A.; Walsh, Kathleen M.

2014-01-01

Purpose: The purpose of this initial feasibility study was to determine whether brief instruction in toy talk would change grammatical properties of adult language, specifically 3rd person lexical noun phrase (NP) subjects. Method: Eighteen college students participated in the study. The use of 3rd person subjects was examined before and after…

78 FR 26680 - Audit and Financial Management Advisory Committee (AFMAC)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-07

... Administration, 409 3rd Street SW., Office of the Chief Financial Officer Conference Room, 6th Floor, Washington... placed on the agenda. Jonathan Carver, Chief Financial Officer, 409 3rd Street SW., 6th Floor, Washington... Donna Wood at (202) 619- 1608, email: [email protected] ; SBA, Office of Chief Financial Officer, 409...

75 FR 34450 - Filing Dates for the Indiana Special Election in the 3rd Congressional District

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-17

... 3rd Congressional District AGENCY: Federal Election Commission. ACTION: Notice of filing dates for special election. SUMMARY: Indiana has scheduled a Special General Election on November 2, 2010, to fill.... Committees required to file reports in connection with the Special General Election on November 2, 2010...

Predictive Modeling of Structural Sensing for Aerospace Applications

DTIC Science & Technology

2015-08-03

3rd European workshop on structural health monitoring, 5–7 July 2006, Granada , Spain. Castaings M, Le Clezio E and Hosten B (2002) Modal decom...monitoring. In: 3rd European workshop on structural health monitoring, 5–7 July 2006, Granada , Spain. Peng H, Meng G and Li F (2009) Modeling of wave propaga

31 CFR Appendix H to Subpart A of... - United States Mint

Code of Federal Regulations, 2011 CFR

2011-07-01

... Act Officer, United States Mint, Judiciary Square Building, 7th floor, 633 3rd Street, NW., Washington... Request, Freedom of Information/Privacy Act Officer, United States Mint, Judiciary Square Building, 7th... Information Appeal, Director, United States Mint, Judiciary Square Building, 7th Floor, 633 3rd Street, NW...

31 CFR Appendix H to Subpart A of... - United States Mint

Code of Federal Regulations, 2013 CFR

2013-07-01

... Act Officer, United States Mint, Judiciary Square Building, 7th floor, 633 3rd Street, NW., Washington... Request, Freedom of Information/Privacy Act Officer, United States Mint, Judiciary Square Building, 7th... Information Appeal, Director, United States Mint, Judiciary Square Building, 7th Floor, 633 3rd Street, NW...

31 CFR Appendix H to Subpart A of... - United States Mint

Code of Federal Regulations, 2012 CFR

2012-07-01

... Act Officer, United States Mint, Judiciary Square Building, 7th floor, 633 3rd Street, NW., Washington... Request, Freedom of Information/Privacy Act Officer, United States Mint, Judiciary Square Building, 7th... Information Appeal, Director, United States Mint, Judiciary Square Building, 7th Floor, 633 3rd Street, NW...

31 CFR Appendix H to Subpart A of... - United States Mint

Code of Federal Regulations, 2014 CFR

2014-07-01

... Act Officer, United States Mint, Judiciary Square Building, 7th floor, 633 3rd Street, NW., Washington... Request, Freedom of Information/Privacy Act Officer, United States Mint, Judiciary Square Building, 7th... Information Appeal, Director, United States Mint, Judiciary Square Building, 7th Floor, 633 3rd Street, NW...

Effects of Trophic Modes, Carbon Sources, and Salinity on the Cell Growth and Lipid Accumulation of Tropic Ocean Oilgae Strain Desmodesmus sp. WC08.

PubMed

Zhao, Zhenyu; Ma, Shasha; Li, Ang; Liu, Pinghuai; Wang, Meng

2016-10-01

The effects of trophic modes, carbon sources, and salinity on the growth and lipid accumulation of a marine oilgae Desmodesmus sp. WC08 in different trophic cultures were assayed by single factor experiment based on the blue-green algae medium (BG-11). The results implied that biomass and lipid accumulation culture process were optimized depending on the tophic modes, sorts, and concentration of carbon sources and salinity in the cultivation. There was no significant difference in growth or lipid accumulation with Na 2 CO 3 amendment or NaHCO 3 amendment. However, Na 2 CO 3 amendment did enhance the biomass and lipid accumulation to some extent. The highest Desmodesmus sp. WC08 biomass and lipid accumulation was achieved in the growth medium with photoautotrophic cultivation, 0.08 g L -1 Na 2 CO 3 amendment and 15 g L -1 sea salt, respectively.

Effects of moisture content on mechanical properties, transparency, and thermal stability of yuba film.

PubMed

Zhang, Siran; Kim, Nayeon; Yokoyama, Wallace; Kim, Yookyung

2018-03-15

Yuba is the skin formed at the surface during the heating of soymilk. The 3rd, 7th, and 11th films were evaluated for properties at different RH. At 39% RH, the 11th film had the lowest moisture, while the 3rd film had the highest moisture. However, at 75% RH, reverse moisture results were obtained. The tensile strengths of the 3rd and 11th films were highest at 15% moisture, whereas the tensile strength of the 7th film was highest at 25% moisture. Elongation of the 3rd (127%) and 11th (85%) films were highest at 25% moisture. The light transmittance of the films was low and opaque at 5% moisture. The films were transparent at 23%-28% moisture, but became opaque as the moisture increased. The films at 39% RH (ΔH, 113-203J/g) had higher thermal stability than those at 87% RH (ΔH, 315-493J/g). Moisture content markedly changed the yuba film properties. Copyright © 2017 Elsevier Ltd. All rights reserved.

Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation

NASA Technical Reports Server (NTRS)

D'Alonzo, Richard C.; Selvamurugan, Nagarajan; Karsenty, Gerard; Partridge, Nicola C.

2002-01-01

Previously, we determined that the activator protein-1 (AP-1)-binding site and the runt domain (RD)-binding site and their binding proteins, c-Fos.c-Jun and Cbfa, regulate the collagenase-3 promoter in parathyroid hormone-treated and differentiating osteoblasts. Here we show that Cbfa1 and c-Fos.c-Jun appear to cooperatively bind the RD- and AP-1-binding sites and form ternary structures in vitro. Both in vitro and in vivo co-immunoprecipitation and yeast two-hybrid studies further demonstrate interaction between Cbfa1 with c-Fos and c-Jun in the absence of phosphorylation and without binding to DNA. Additionally, only the runt domain of Cbfa1 was required for interaction with c-Jun and c-Fos. In mammalian cells, overexpression of Cbfa1 enhanced c-Jun activation of AP-1-binding site promoter activity, demonstrating functional interaction. Finally, insertion of base pairs that disrupted the helical phasing between the AP-1- and RD-binding sites also inhibited collagenase-3 promoter activation. Thus, we provide direct evidence that Cbfa1 and c-Fos.c-Jun physically interact and cooperatively bind the AP-1- and RD-binding sites in the collagenase-3 promoter. Moreover, the AP-1- and RD-binding sites appear to be organized in a specific required helical arrangement that facilitates transcription factor interaction and enables promoter activation.

PREFACE: 3rd International Congress on Mechanical Metrology (CIMMEC2014)

NASA Astrophysics Data System (ADS)

2015-10-01

From October 14th to 16th 2014, The Brazilian National Institute of Metrology, Quality, and Technology (Inmetro) and the Brazilian Society of Metrology (SBM) organized the 3rd International Congress on Mechanical Metrology (3rd CIMMEC). The 3rd CIMMEC was held in the city of Gramado, Rio Grande do Sul, Brazil. Anticipating the interest and enthusiasm of the technical-scientific community, the Organizing Institutions invite people and organizations to participate in this important congress, reiterating the commitment to organize an event according to highest international standards. This event has been conceived to integrate people and organizations from Brazil and abroad in the discussion of advanced themes in metrology. Manufacturers and dealers of measuring equipment and standards, as well as of auxiliary accessories and bibliographic material, had the chance to promote their products and services in stands at the Fair, which has taken place alongside the Congress. The 3rd CIMMEC consisted of five Keynote Speeches and 116 regular papers. Among the regular papers, the 25 most outstanding ones, comprising a high quality content on Mechanical Metrology, were selected to be published in this issue of Journal of Physics: Conference Series. It is our great pleasure to present this volume of Journal of Physics: Conference Series to the scientific community to promote further research in Mechanical Metrology and related areas. We believe that this volume will be both an excellent source of scientific material in the fast evolving fields that were covered by CIMMEC 2014.

The Goodrich 3rd generation DB-110 system: operational on tactical and unmanned aircraft

NASA Astrophysics Data System (ADS)

Iyengar, Mrinal; Lange, Davis

2006-05-01

Goodrich's DB-110 Reconnaissance Airborne Pod for TORnado (RAPTOR) and Data Link Ground Station (DLGS) have been used operationally for several years by the Royal Air Force (RAF). A variant of the RAPTOR DB-110 Sensor System is currently being used by the Japan Maritime Self Defense Force (JMSDF). Recently, the DB-110 system was flown on the Predator B Unmanned Aerial Vehicle (UAV), demonstrating the DB-110 system's utility on unmanned reconnaissance aircraft. The DB-110 is a dual-band EO and IR imaging capability for long, medium, and short standoff ranges, including oblique and over-flight imaging, in a single sensor package. The DB-110 system has also proven performance for real-time high bandwidth data link imagery transmission. Goodrich has leveraged this operational experience in building a 3rd Generation DB-110 system including new Reconnaissance Airborne Pod and Ground System, to be first used by the Polish Air Force. This 3rd Generation system maintains all the capability of the current 2nd Generation DB-110 system and adds several new features. The 3rd Generation system upgrades include an increase in resolution via new focal planes, addition of a third ("super-wide") field of view, and new avionics. This paper summarizes the Goodrich DB-110 3rd Generation System in terms of its basic design and capabilities. Recent demonstration of the DB-110 on the Predator B UAV is overviewed including sample imagery.

Off-premise alcohol purchasing in Australia: Variations by age group, income level and annual amount purchased.

PubMed

Jiang, Heng; Callinan, Sarah; Livingston, Michael; Room, Robin

2017-03-01

To delineate what type and how much alcohol is purchased from different types of off-licence premises and how this varies across demographic sub-groups, as a basis for public debate and decisions on pricing and planning policies to reduce alcohol-related harm in Australia. The data on alcohol purchasing from off-licence premises are taken from the Australian Alcohol Consumption and Purchasing survey-a nationally representative landline and mobile telephone survey in 2013 on the experiences with alcohol consumption and purchasing of 2020 Australians aged 16+. The present analysis uses data from 1730 respondents who purchased alcohol from off-licence premises in the previous 6 months. The majority (54%) of alcohol purchased from off-licence premises was sold from liquor barns (large warehouse-style alcohol stores), with bottle shops (31%) the second most common outlet. Cask wine was the cheapest alcohol available at off-licence premises in Australia. Respondents in higher alcohol purchasing quintiles and with those with lower income purchased a higher percentage of cheaper alcohol in their total volume of purchasing than lower purchasing quintiles and those with middle and higher income, and younger respondents purchased more expensive alcohol than older age groups. A minimum unit price or increasing alcohol taxes may effectively reduce alcohol purchasing for lower income heavy alcohol purchasers and older age groups from off-licence premise sources, and may be less effective on younger age groups. [Jiang H, Callinan S, Livingston M, Room R. Off-premise alcohol purchasing in Australia: Variations by age group, income level and annual amount purchased. Drug Alcohol Rev 2017;36:210-219]. © 2016 Australasian Professional Society on Alcohol and other Drugs.

25 CFR 81.2 - Purpose and scope.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) Holding Secretarial elections for voting on proposed constitutions when tribes wish to reorganize, (2) Adopting constitutional amendments, (3) Ratifying and amending charters, (4) Revoking constitutions, and (5...

The Lived Experiences of 3rd Generation and beyond U.S.-Born Mexican Heritage College Students: A Qualitative Study

ERIC Educational Resources Information Center

Galvan, Richard

2011-01-01

The purpose of this study was to describe the psychosocial and identity challenges of 3rd generation and beyond U.S.-born (3GAB-USB) Mexican heritage college students. Alvarez (1973) has written about the psychosocial impact "hybridity" can have on a U.S.- born (USB) Mexican individual who incorporates two distinct cultures (American and…

What is FirstSchool? Issues in PreK-3rd Education. Number One

ERIC Educational Resources Information Center

Ritchie, Sharon; Maxwell, Kelly; Clifford, Richard

2009-01-01

FirstSchool is part of a national PreK-3rd movement of schools, districts, educators and universities seeking to improve how children from ages 3 to 8 learn and develop in schools. While these different projects use a variety of names, all are working to connect high-quality PreK programs with high-quality elementary schools. FirstSchool is…

The Analysis of Risk Factors in No Thumb Test in Total Knee Arthroplasty

PubMed Central

Kim, Jee Hyoung; Ko, Dong Oh; Yoo, Chang Wook; Chun, Tae Hwan; Lee, Jung Soo

2011-01-01

Background We would like to analyze the risk factors of no thumb test among knee alignment tests during total knee arthroplasty surgery. Methods The 156 cases of total knee arthroplasty by an operator from October 2009 to April 2010 were analyzed according to preoperative indicators including body weight, height, degree of varus deformity, and patella subluxation and surgical indicators such as pre-osteotomy patella thickness, degree of patella degeneration, no thumb test which was evaluated after medial prepatella incision and before bone resection (1st test), no thumb test which was evaluated with corrective valgus stress (2nd test, J test), and the kind of prosthesis. We comparatively analyzed indicators affecting no thumb test (3rd test). Results There was no relation between age, sex, and body weight and no thumb test (3rd test). Patellar sulcus angle (p = 0.795), patellar congruence angle (p = 0.276) and preoperative mechanical axis showed no relationship. The 1st no thumb test (p = 0.007) and 2nd test (p = 0.002) showed significant relation with the 3rd no thumb test. Among surgical indicators, pre-osteotomy patella thickness (p = 0.275) and degeneration of patella (p = 0.320) were not relevant but post-osteotomy patellar thickness (p = 0.002) was relevant to no thumb test (3rd test). According to prosthesis, there was no significance with Nexgen (p = 0.575). However, there was significant correlation between Scorpio (p = 0.011), Vanguard (p = 0.049) and no thumb test (3rd test). Especially, Scorpio had a tendency to dislocate the patella, but Vanguard to stabilize the patella. Conclusions No thumb test (3rd test) is correlated positively with 1st test, 2nd test, and post-osteotomy patella thickness. Therefore, the more patella osteotomy and the prosthesis with high affinity to patellofemoral alignment would be required for correct patella alignment. PMID:22162789

[When should a stool culture be done in adults with nosocomial diarrhea?].

PubMed

Mathieu, Alexandre; Tachet, Anne; Pariente, Alexandre

2005-01-29

To assess the diagnostic efficacy, cost and possible corrective measure of the indications for routine stool cultures in nosocomial diarrhoea in adults. A retrospective study over a 10-month period of 660 standard stool cultures, 256 of which were conducted after the 3rd day of hospitalisation, conducted in 528 patients at the hospital centre in Pau. The positivity rate of the stool cultures was of 26/336 patients (7.7%), and of 37/404 examinations (9%) within the first three days of hospitalisation, versus 2/192 patients (1%) and 3/256 examinations (1%) after the 3rd day of hospitalisation (p<0.05). In 83 patients a stool culture was repeated, and was only positive in one patient with an initially negative culture. If a stool culture had not been performed after the 3rd day, 2 infections would not have been diagnosed (1 salmonella and 1 K. oxytoca) and 256 stool cultures could have been economised (estimated cost: 6,144 euro). Moreover, by eliminating repeated stool cultures, 3 infections would not have been diagnosed (2 salmonella, and 1 K. oxytoca) and 321 stool cultures would have been avoided (estimated cost: 7,704 euro). If the stool cultures had been conducted after the 3rd day of hospitalisation only in those aged over 64 with comorbidity, immunosuppression or within the context of an epidemic, no false negative would have been observed and 149 stool cultures would have been economised (estimated cost: 3,576 euro). The positivity rate of the search for C. difficile, only conducted on explicit request from the practitioners, was of 5/23 (22%) and 4/28 (14%) before and after the 3rd day of hospitalisation (non-significant difference). Restriction of standard stool cultures after the 3rd day of hospitalisation to patients aged over 64 with comorbidity, to the immunodepressed, and within an epidemic context would economise around 4,300 euro per month in a medium-sized general hospital. No systematic restriction should be applied to the search for C. difficile.

Studies in the Management of Social R&D: Selected Policy Areas. Study Project on Social Research and Development, Volume 3.

ERIC Educational Resources Information Center

Lynn, Laurence E., Jr., Ed.

Interviews with 180 federal agencies that conduct social research and development (R&D) were conducted and documents were examined to determine: (1) what types of social R&D are supported, and what levels of support are provided; (2) who defines the problems to be researched, who decides the level of support to be provided, and how investigators…

IBM1, a JmjC domain-containing histone demethylase, is involved in the regulation of RNA-directed DNA methylation through the epigenetic control of RDR2 and DCL3 expression in Arabidopsis

PubMed Central

Fan, Di; Dai, Yan; Wang, Xuncheng; Wang, Zhenjie; He, Hang; Yang, Hongchun; Cao, Ying; Deng, Xing Wang; Ma, Ligeng

2012-01-01

Small RNA-directed DNA methylation (RdDM) is an important epigenetic pathway in Arabidopsis that controls the expression of multiple genes and several developmental processes. RNA-DEPENDENT RNA POLYMERASE 2 (RDR2) and DICER-LIKE 3 (DCL3) are necessary factors in 24-nt small interfering RNA (siRNA) biogenesis, which is part of the RdDM pathway. Here, we found that Increase in BONSAI Methylation 1 (IBM1), a conserved JmjC family histone demethylase, is directly associated with RDR2 and DCL3 chromatin. The mutation of IBM1 induced the hypermethylation of H3K9 and DNA non-CG sites within RDR2 and DCL3, which repressed their expression. A genome-wide analysis suggested that the reduction in RDR2 and DCL3 expression affected siRNA biogenesis in a locus-specific manner and disrupted RdDM-directed gene repression. Together, our results suggest that IBM1 regulates gene expression through two distinct pathways: direct association to protect genes from silencing by preventing the coupling of histone and DNA methylation, and indirect silencing of gene expression through RdDM-directed repression. PMID:22772985

Coarse Particulate Air Pollution Associated with Increased Risk of Hospital Admissions for Respiratory Diseases in a Tropical City, Kaohsiung, Taiwan.

PubMed

Cheng, Meng-Hsuan; Chiu, Hui-Fen; Yang, Chun-Yuh

2015-10-16

This study was undertaken to determine whether there was an association between coarse particles (PM₂.₅-₁₀) levels and frequency of hospital admissions for respiratory diseases (RD) in Kaohsiung, Taiwan. Hospital admissions for RD including chronic obstructive pulmonary disease (COPD), asthma, and pneumonia, and ambient air pollution data levels for Kaohsiung were obtained for the period from 2006 to 2010. The relative risk of hospital admissions for RD was estimated using a case-crossover approach, controlling for weather variables, day of the week, seasonality, and long-term time trends. For the single pollutant model (without adjustment for other pollutants), increased rate of admissions for RD were significantly associated with higher coarse PM levels only on cool days (<25 °C), with a 10 µg/m³ elevation in PM₂.₅-₁₀ concentrations associated with a 3% (95% CI = 1%-5%) rise in COPD admissions, 4% (95% CI = 1%-7%) increase in asthma admissions, and 3% (95% CI = 2%-4%) rise in pneumonia admissions. No significant associations were found between coarse particle levels and the number of hospital admissions for RD on warm days. In the two-pollutant models, PM₂.₅-₁₀ levels remained significantly correlated with higher rate of RD admissions even controlling for sulfur dioxide, nitrogen dioxide, carbon monoxide, or ozone on cool days. This study provides evidence that higher levels of PM₂.₅-₁₀ enhance the risk of hospital admissions for RD on cool days.

76 FR 65739 - Iowa; Amendment No. 3 to Notice of a Major Disaster Declaration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-24

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Internal Agency Docket No. FEMA-1998-DR; Docket ID FEMA-2011-0001] Iowa; Amendment No. 3 to Notice of a Major Disaster Declaration AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. [[Page 65740

15 CFR 714.4 - Amended declaration or report.

Code of Federal Regulations, 2014 CFR

2014-01-01

... chemicals exported; and (4) Source(s) of Schedule 3 chemicals imported. (c) Changes to company and plant...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS § 714.4 Amended declaration or report. In order for BIS to maintain...

15 CFR 714.4 - Amended declaration or report.

Code of Federal Regulations, 2012 CFR

2012-01-01

... chemicals exported; and (4) Source(s) of Schedule 3 chemicals imported. (c) Changes to company and plant...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS § 714.4 Amended declaration or report. In order for BIS to maintain...

15 CFR 714.4 - Amended declaration or report.

Code of Federal Regulations, 2013 CFR

2013-01-01

... chemicals exported; and (4) Source(s) of Schedule 3 chemicals imported. (c) Changes to company and plant...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS § 714.4 Amended declaration or report. In order for BIS to maintain...

40 CFR 52.70 - Identification of plan.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Hearings, Written Testimony, etc. I-2 Recommendations for attainment/Nonattainment designations II-1 Alaska... for the Fairbanks Municipal Utilities System IV-3 Testing Procedures V-1 Air Quality Data An amended... Control Plan Amendment (which includes Appendix A the Alaska Statutes Title 46, Chapter 14, Article 3...

Comparison of turnaround time and total cost of HIV testing before and after implementation of the 2014 CDC/APHL Laboratory Testing Algorithm for diagnosis of HIV infection.

PubMed

Chen, Derrick J; Yao, Joseph D

2017-06-01

Updated recommendations for HIV diagnostic laboratory testing published by the Centers for Disease Control and Prevention and the Association of Public Health Laboratories incorporate 4th generation HIV immunoassays, which are capable of identifying HIV infection prior to seroconversion. The purpose of this study was to compare turnaround time and cost between 3rd and 4th generation HIV immunoassay-based testing algorithms for initially reactive results. The clinical microbiology laboratory database at Mayo Clinic, Rochester, MN was queried for 3rd generation (from November 2012 to May 2014) and 4th generation (from May 2014 to November 2015) HIV immunoassay results. All results from downstream supplemental testing were recorded. Turnaround time (defined as the time of initial sample receipt in the laboratory to the time the final supplemental test in the algorithm was resulted) and cost (based on 2016 Medicare reimbursement rates) were assessed. A total of 76,454 and 78,998 initial tests were performed during the study period using the 3rd generation and 4th generation HIV immunoassays, respectively. There were 516 (0.7%) and 581 (0.7%) total initially reactive results, respectively. Of these, 304 (58.9%) and 457 (78.7%) were positive by supplemental testing. There were 10 (0.01%) cases of acute HIV infection identified with the 4th generation algorithm. The most frequent tests performed to confirm an HIV-positive case using the 3rd generation algorithm, which were reactive initial immunoassay and positive HIV-1 Western blot, took a median time of 1.1 days to complete at a cost of $45.00. In contrast, the most frequent tests performed to confirm an HIV-positive case using the 4th generation algorithm, which included a reactive initial immunoassay and positive HIV-1/-2 antibody differentiation immunoassay for HIV-1, took a median time of 0.4 days and cost $63.25. Overall median turnaround time was 2.2 and 1.5 days, and overall median cost was $63.90 and $72.50 for 3rd and 4th generation algorithms, respectively. Both 3rd and 4th generation HIV immunoassays had similar total numbers of tests performed and positivity rates during the study period. A greater proportion of reactive 4th generation immunoassays were confirmed to be positive, and the 4th generation algorithm identified several cases of acute HIV infection that would have been missed by the 3rd generation algorithm. The 4th generation algorithm had a more rapid turnaround time but higher cost for confirmed positive HIV infections and overall, compared to the 3rd generation algorithm. Copyright © 2017 Elsevier B.V. All rights reserved.

Use of Fe/Al drinking water treatment residuals as amendments for enhancing the retention capacity of glyphosate in agricultural soils.

PubMed

Zhao, Yuanyuan; Wendling, Laura A; Wang, Changhui; Pei, Yuansheng

2015-08-01

Fe/Al drinking water treatment residuals (WTRs), ubiquitous and non-hazardous by-products of drinking water purification, are cost-effective adsorbents for glyphosate. Given that repeated glyphosate applications could significantly decrease glyphosate retention by soils and that the adsorbed glyphosate is potentially mobile, high sorption capacity and stability of glyphosate in agricultural soils are needed to prevent pollution of water by glyphosate. Therefore, we investigated the feasibility of reusing Fe/Al WTR as a soil amendment to enhance the retention capacity of glyphosate in two agricultural soils. The results of batch experiments showed that the Fe/Al WTR amendment significantly enhanced the glyphosate sorption capacity of both soils (p<0.001). Up to 30% of the previously adsorbed glyphosate desorbed from the non-amended soils, and the Fe/Al WTR amendment effectively decreased the proportion of glyphosate desorbed. Fractionation analyses further demonstrated that glyphosate adsorbed to non-amended soils was primarily retained in the readily labile fraction (NaHCO3-glyphosate). The WTR amendment significantly increased the relative proportion of the moderately labile fraction (HCl-glyphosate) and concomitantly reduced that of the NaHCO3-glyphosate, hence reducing the potential for the release of soil-adsorbed glyphosate into the aqueous phase. Furthermore, Fe/Al WTR amendment minimized the inhibitory effect of increasing solution pH on glyphosate sorption by soils and mitigated the effects of increasing solution ionic strength. The present results indicate that Fe/Al WTR is suitable for use as a soil amendment to prevent glyphosate pollution of aquatic ecosystems by enhancing the glyphosate retention capacity in soils. Copyright © 2015. Published by Elsevier B.V.

Assessing quality of life of self-reported rheumatic patients.

PubMed

Ferreira, Pedro L; Gonçalves, Sónia P; Ferreira, Lara N; Pereira, Luis N; Antunes, Patrícia; Gouveia, Nélia; Rodrigues, Ana; Canhão, Helena; Branco, Jaime

2016-09-01

The aims of this study were to assess the health-related quality of life (HRQoL) in patients with self-reported rheumatic diseases (RD), to classify self-reported rheumatic patients in groups according to their health state and to explore the associations between health status and sociodemographic variables. Data came from the Portuguese Epidemiologic study of the RD. A sample of the Portuguese population aged 18 or more (n = 10,661) stratified by region and locality dimension was interviewed by trained interviewers and answered a standardized questionnaire that included the SF-36v1, the EQ-5D-3L, medical history, identification of potential rheumatic diseases, sociodemographic characteristics, among others. Descriptive statistics and parametric tests were used to compare HRQoL of respondents with and without RD. Comparisons with normative data from the Portuguese population were also carried out. A cluster analysis was used to classify respondents into homogeneous groups. Regression analyses were used to identify factors associated with HRQoL. Respondents with self-reported RD assigned a lower self-perception to their health status. The burden of disease was observed mainly in physical function, role physical and bodily pain. The EQ-5D-3L dimensions show similar results: the intensity of problems is significantly more evident in respondents with self-reported RD. HRQoL of respondents with self-reported RD is related to sociodemographic variables and is significantly lower when compared with the Portuguese population. Four clusters of homogeneous respondents with self-reported RD were formed and characterized according to a number of variables. Factors associated with HRQoL were identified. In conclusion, suffering from a self-reported RD has a significant impact on self-perceived health status and on the quality of life.

5 CFR 2504.15 - Procedures for appeal of determination deny access to or amendment of records.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Procedures for appeal of determination deny access to or amendment of records. 2504.15 Section 2504.15 Administrative Personnel OFFICE OF ADMINISTRATION, EXECUTIVE OFFICE OF THE PRESIDENT PRIVACY ACT REGULATIONS § 2504.15 Procedures for appeal of determination deny access to or amendment o...

To Keep and Bear Arms: Gun Control and the Second Amendment. Teacher's Guide.

ERIC Educational Resources Information Center

Edwards, Amy N.; Walker, Tim

This teacher's guide is designed to accompany the two-part videotape "To Keep and Bear Arms: Gun Control and the Second Amendment." The videotape and teacher's guide should help students to: (1) understand the history of the Second Amendment; (2) examine how guns and gun control laws affect people's lives; (3) compare and contrast the…

78 FR 38087 - Self-Regulatory Organizations; BOX Options Exchange LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-25

... To Amend BOX Rule 3150 (Reports Related to Position Limits) June 19, 2013. Pursuant to Section 19(b... Rule Change The Exchange proposes to amend BOX Rule 3150 (Reports Related to Position Limits). The text... proposes to amend BOX Rule 3150 (Reports Related to Position Limits) to exempt BOX Market Makers \\3\\ from...

76 FR 60516 - New Hampshire; Amendment No. 4 to Notice of a Major Disaster Declaration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-29

.... FEMA-4026-DR; Docket ID FEMA-2011-0001] New Hampshire; Amendment No. 4 to Notice of a Major Disaster... notice of a major disaster declaration for the State of New Hampshire (FEMA-4026-DR), dated September 3... major disaster declaration for the State of New Hampshire is hereby amended to include the following...

76 FR 56776 - New Hampshire; Amendment No. 1 to Notice of a Major Disaster Declaration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-14

.... FEMA-4026-DR; Docket ID FEMA-2011-0001] New Hampshire; Amendment No. 1 to Notice of a Major Disaster... notice of a major disaster declaration for the State of New Hampshire (FEMA-4026-DR), dated September 3... major disaster declaration for the State of New Hampshire is hereby amended to include the Individual...

77 FR 18104 - Amendment of Restricted Areas R-5801 and R-5803; Chambersburg, PA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-27

...-0174; Airspace Docket No. 11-AEA-3] RIN 2120-AA66 Amendment of Restricted Areas R-5801 and R-5803.... SUMMARY: This action makes a minor editorial change to the time of designation for restricted areas R-5801 and R-5803, Chambersburg, PA, to remove the abbreviation ``EST.'' This amendment does not change the...

Morris K. Udall Scholarship and Excellence in National Environmental Policy Amendments Act of 2009

THOMAS, 111th Congress

Rep. Grijalva, Raul M. [D-AZ-7

2009-02-12

Senate - 10/08/2009 Message on House action received in Senate and at desk: House amendment to Senate amendment. (All Actions) Notes: For further action, see S.1818, which became Public Law 111-90 on 11/3/2009. Tracker: This bill has the status Resolving DifferencesHere are the steps for Status of Legislation:

Behaviors of heavy metals (Cd, Cu, Ni, Pb and Zn) in soil amended with composts.

PubMed

Gusiatin, Zygmunt Mariusz; Kulikowska, Dorota

2016-09-01

This study investigated how amendment with sewage sludge compost of different maturation times (3, 6, 12 months) affected metal (Cd, Cu, Ni, Pb, Zn) bioavailability, fractionation and redistribution in highly contaminated sandy clay soil. Metal transformations during long-term soil stabilization (35 months) were determined. In the contaminated soil, Cd, Ni and Zn were predominately in the exchangeable and reducible fractions, Pb in the reducible fraction and Cu in the reducible, exchangeable and oxidizable fractions. All composts decreased the bioavailability of Cd, Ni and Zn for up to 24 months, which indicates that cyclic amendment with compost is necessary. The bioavailability of Pb and Cu was not affected by compost amendment. Based on the reduced partition index (IR), metal stability in amended soil after 35 months of stabilization was in the following order: Cu > Ni = Pb > Zn > Cd. All composts were more effective in decreasing Cd, Ni and Zn bioavailability than in redistributing the metals, and increasing Cu redistribution more than that of Pb. Thus, sewage sludge compost of as little as 3 months maturation can be used for cyclic amendment of multi-metal-contaminated soil.

Superfund record of decision amendment (EPA Region 5): Allied Chemical and Ironton Coke, Ironton, OH, September 30, 1998

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This decision document, together with the Allied Chemical/Ironton Coke Record of Decision (ROD) dated December 28, 1990, the first Allied Chemical/Ironton Coke ROD Amendment dated July 31, 1995 (ROD Amendment No 1), and the second ROD Amendment dated September 4, 1997 (ROD Amendment No 2), presents the selected remedial action for the Allied Chemical/Ironton Coke site. The remedy selected in the 1990 ROD, 1995 ROD Amendment No. 1, and 1997 ROD Amendment No. 2 for the site is a final remedial action. Through ROD Amendment No. 3 the following components of the selected remedy are being modified: Replace in-situ bioremediationmore » of 457,000 cubic yards of soil in Lagoons 1--4 with hot spot excavation and wetland development; and Replace incineration of Lagoon 5 materials with recycling, treatment, and/or disposal of the K087 listed waste in an approved off-site hazardous waste facility and the use of the remaining material, excluding debris, as an alternative fuel.« less

Auctioning Airport Slots?

NASA Technical Reports Server (NTRS)

Gruyer, Nicolas; Lenoir, Nathalie

2003-01-01

The current allocation of slots on congested European airports constitutes an obstacle to the effective liberalisation of air transportation undertaken in Europe. With a view to favouring effluent slot utilisation and competition, as is the goal of the Euopean commission, we propose to use a market mechanism, based on temporary" utilisation licences. In order to allocate those licences, we propose and describe an iterated combinatorial auction mechanism where a percentage of licences would be reallocated each season. A secondary market would also be set up in order to reallocate slots during a season. Since a combinatorial auction involve a complex optimisation procedure, we describe how it can be made to work in the case of auctions.

Delays in the delivery room of a primary maternity unit: a retrospective analysis of obstetric outcomes.

PubMed

Giannella, Luca; Mfuta, Kabala; Pedroni, Deborah; Delrio, Elisabetta; Venuta, Agnese; Bergamini, Ezio; Cerami, Lillo B

2013-04-01

To compare obstetric outcomes in women undergoing vaginal delivery with or without delay in the 2nd and 3rd stage of labour (SOL). This is an observational retrospective study including 10,416 full-term vaginal deliveries occurred at a primary obstetric unit. Our sample was divided according to the length of 2nd and 3rd SOL: >2 h vs. ≤2 h; and >1 h vs. ≤1 h, respectively. Obstetric outcomes were compared using univariate and multivariate analysis. A prolonged 2nd SOL was associated with severe perineal tears (odds ratio (OR) = 3.53), episiotomy (OR = 3.25), major post-partum hemorrhage (PPH) (OR = 2.35), operative delivery (OR = 3.54), and Asian ethnicity (OR = 12.12). Likewise, a prolonged 3rd SOL was associated with operative deliveries (OR = 10.49), labor induction (OR = 3.24), non-use of oxytocin after delivery (OR = 12.39), major PPH (OR = 46.95), retained placenta (OR = 3.57) and female fetal gender (OR = 4.07). even at a primary care setting, where there are mostly low-risk pregnancies, a prolonged 2nd and 3rd SOL may occur and lead to poor obstetric outcomes. Our findings raise a very controversial issue about the meaning of "low obstetrics risk", given the unpredictability of any labor, and the management of complications in the delivery room of primary maternity units.

A Quantitative Study of Right Dislocation in Cantonese Spoken Discourse.

PubMed

Lai, Christy Choi-Ting; Law, Sam-Po; Kong, Anthony Pak-Hin

2017-12-01

Right Dislocation (RD) has been suggested to be a focus marking device carrying an affective function motivated by limited planning time in conversation. The current study investigated the effects of genre type, planning load and affective function on the use of RD in Cantonese monologues. Discourse data were extracted from a recently developed corpus of oral narratives in Cantonese Chinese containing language samples from 144 native Cantonese speakers evenly distributed in age, education levels and gender. Three genre types representing different structures, styles and degrees of topic familiarity were chosen for an RD analysis: procedural description, story-telling and recount of personal event. The results revealed that genre types and planning load influenced the rate of RD occurrence. (1) Specifically, the lowest proportion of RD occurred in procedural description, assumed to be the most structured genre; whereas the highest rate was found in personal event recount, considered to be the most stylized and less structured genre. (2) The highest proportion of RD appeared near the end of a narrative, where heavier cognitive load is demanded compared with the beginning of a narrative; moreover, RD also tended to co-occur with disfluency. (3) There was a high percentage of RD tokens in the personal event recount for expressing explicit emotions; and (4) a lower rate of occurrence of RD was found in monologues than previous studies based on conversations. The overall findings suggest that the use of RD is sensitive to genre structure and style, as well as planning load effects.

Comparison of gestational dating methods and implications for exposure-outcome associations: an example with PM2.5 and preterm birth.

PubMed

Rappazzo, Kristen M; Lobdell, Danelle T; Messer, Lynne C; Poole, Charles; Daniels, Julie L

2017-02-01

Estimating gestational age is usually based on date of last menstrual period (LMP) or clinical estimation (CE); both approaches introduce potential bias. Differences in methods of estimation may lead to misclassification and inconsistencies in risk estimates, particularly if exposure assignment is also gestation-dependent. This paper examines a 'what-if' scenario in which alternative methods are used and attempts to elucidate how method choice affects observed results. We constructed two 20-week gestational age cohorts of pregnancies between 2000 and 2005 (New Jersey, Pennsylvania, Ohio, USA) using live birth certificates: one defined preterm birth (PTB) status using CE and one using LMP. Within these, we estimated risk for 4 categories of preterm birth (PTBs per 10 6 pregnancies) and risk differences (RD (95% CIs)) associated with exposure to particulate matter (PM 2.5 ). More births were classified preterm using LMP (16%) compared with CE (8%). RD divergences increased between cohorts as exposure period approached delivery. Among births between 28 and 31 weeks, week 7 PM 2.5 exposure conveyed RDs of 44 (21 to 67) for CE and 50 (18 to 82) for LMP populations, while week 24 exposure conveyed RDs of 33 (11 to 56) and -20 (-50 to 10), respectively. Different results from analyses restricted to births with both CE and LMP are most likely due to differences in dating methods rather than selection issues. Results are sensitive to choice of gestational age estimation, though degree of sensitivity can vary by exposure timing. When both outcome and exposure depend on estimate of gestational age, awareness of nuances in the method used for estimation is critical. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Third Grade Literacy Policies: Identification, Intervention, Retention

ERIC Educational Resources Information Center

Rose, Stephanie; Schimke, Karen

2012-01-01

Students not reading proficiently by the end of 3rd grade are four times more likely than proficient readers to drop out of high school. This fact and other recent research on the importance of early literacy skills have culminated in an intense focus on improving 3rd-grade reading proficiency. The challenges of improving literacy are, in turn,…

Meeting report on the 3rd International Congress on Developmental Origins of Health and Disease (DOHaD)

USDA-ARS?s Scientific Manuscript database

Developmental Origins of Health and Disease (DOHaD) focuses on the earliest stages of human development, and provides a novel paradigm to complement other strategies for lifelong prevention of common chronic health conditions. The 3rd International Congress on DOHaD, held in 2005, retained the most ...

Parents in Partnership for Proficiency: For 3rd & 4th Graders and Their Families.

ERIC Educational Resources Information Center

Neiner, Christine; And Others

This document contains a series of learning materials for 3rd and 4th graders and their families. The materials are designed to augment classroom learning. Included are worksheets, games, and other skill building activities for writing, reading, math, citizenship, and science. These activities are meant to help children prepare for proficiency…

The Effect of Book Blogging on the Motivation of 3rd-Grade Students

ERIC Educational Resources Information Center

Swanson, Kristen N.; Legutko, Robert S.

2008-01-01

A Web 2.0 technology was implemented during reading instruction in one 3rd-grade classroom in suburban southeastern Pennsylvania. Trained preservice teachers provided feedback to students via the World Wide Web to enhance their performance and social connections. Motivation scores were measured before and after the intervention was implemented. A…

Starting Young: Massachusetts Birth-3rd Grade Policies That Support Children's Literacy Development

ERIC Educational Resources Information Center

Cook, Shayna; Bornfreund, Laura

2015-01-01

Massachusetts is one of a handful of states that is often recognized as a leader in public education, and for good reason. The Commonwealth consistently outperforms most states on national reading and math tests and often leads the pack in education innovations. "Starting Young: Massachusetts Birth-3rd Grade Policies that Support Children's…

Constancy and Variability: Dialogic Literacy Events as Sites for Improvisation in Two 3rd-Grade Classrooms

ERIC Educational Resources Information Center

Jordan, Michelle E.; Santori, Diane

2015-01-01

This multisite study investigates dialogic literacy events that revolved around narrative and informational texts in two 3rd-grade classrooms. The authors offer a metaphor of musical improvisation to contemplate dialogic literacy events as part of the repertoire of teaching and learning experiences. In literacy learning, where there is much…

16. 3RD FLOOR, J.M. LEHMANN CO. FIVEROLL TOILET SOAP MILL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. 3RD FLOOR, J.M. LEHMANN CO. FIVE-ROLL TOILET SOAP MILL INSTALLED 1950, TO WEST; BUCKET CONVEYOR AT RIGHT MOVED WASTE FROM 2ND FLOOR SOAP PRESSES TO 5TH FLOOR RE-MANUFACTURE - Colgate & Company Jersey City Plant, Building No. B-14, 54-58 Grand Street, Jersey City, Hudson County, NJ

Validation of Unsupervised Computer-Based Screening for Reading Disability in Greek Elementary Grades 3 and 4

ERIC Educational Resources Information Center

Protopapas, Athanassios; Skaloumbakas, Christos; Bali, Persefoni

2008-01-01

After reviewing past efforts related to computer-based reading disability (RD) assessment, we present a fully automated screening battery that evaluates critical skills relevant for RD diagnosis designed for unsupervised application in the Greek educational system. Psychometric validation in 301 children, 8-10 years old (grades 3 and 4; including…

Proceedings of the 3rd fire in eastern oak forests conference

Treesearch

Todd F., ed. Hutchinson

2009-01-01

Contains 10 full-length papers and 12 abstracts of posters that were presented at the 3rd Fire in Eastern Oak Forests conference, held in Carbondale, IL, May 20-22, 2008. The conference was attended by over 200 people from a variety of groups, including federal and state agencies, nongovernmental organizations, universities, and private citizens....

16. Typical end post, top chord, bottom chord, vertical lattice ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. Typical end post, top chord, bottom chord, vertical lattice and diagonal connections for the 2nd and 3rd spans. View is of south side of 3rd span just west of its connection with the 4th span. - Cleves Bridge, Spanning Great Miami River on U.S. Highway 50, Cleves, Hamilton County, OH

76 FR 60514 - Pennsylvania; Amendment No. 3 to Notice of an Emergency Declaration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-29

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Internal Agency Docket No. FEMA-3339-EM; Docket ID FEMA-2011-0001] Pennsylvania; Amendment No. 3 to Notice of an Emergency... notice of an emergency declaration for Commonwealth of Pennsylvania (FEMA-3339-EM), dated August 29, 2011...

75 FR 26920 - Mid-Atlantic Fishery Management Council; Spiny Dogfish Amendment 3 Scoping Process

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-13

... Fishery Management Council; Spiny Dogfish Amendment 3 Scoping Process AGENCY: National Marine Fisheries... the Spiny Dogfish Fishery Management Plan (FMP). This notice announces a public process to solicit... and New England Fishery Management Councils (Councils), in cooperation with NMFS, announce that they...

44 CFR 9.3 - Authority.

Code of Federal Regulations, 2014 CFR

2014-10-01

... GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.3 Authority. The authority for these... Flood Insurance Act of 1968, as amended (Pub. L. 90-488); the Flood Disaster Protection Act of 1973, as amended (Pub. L. 93-234); and the National Environmental Policy Act of 1969 (NEPA) (Pub. L. 91-190...

44 CFR 9.3 - Authority.

Code of Federal Regulations, 2013 CFR

2013-10-01

... GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.3 Authority. The authority for these... Flood Insurance Act of 1968, as amended (Pub. L. 90-488); the Flood Disaster Protection Act of 1973, as amended (Pub. L. 93-234); and the National Environmental Policy Act of 1969 (NEPA) (Pub. L. 91-190...

44 CFR 9.3 - Authority.

Code of Federal Regulations, 2010 CFR

2010-10-01

... GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.3 Authority. The authority for these... Flood Insurance Act of 1968, as amended (Pub. L. 90-488); the Flood Disaster Protection Act of 1973, as amended (Pub. L. 93-234); and the National Environmental Policy Act of 1969 (NEPA) (Pub. L. 91-190...

44 CFR 9.3 - Authority.

Code of Federal Regulations, 2012 CFR

2012-10-01

... GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.3 Authority. The authority for these... Flood Insurance Act of 1968, as amended (Pub. L. 90-488); the Flood Disaster Protection Act of 1973, as amended (Pub. L. 93-234); and the National Environmental Policy Act of 1969 (NEPA) (Pub. L. 91-190...

44 CFR 9.3 - Authority.

Code of Federal Regulations, 2011 CFR

2011-10-01

... GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.3 Authority. The authority for these... Flood Insurance Act of 1968, as amended (Pub. L. 90-488); the Flood Disaster Protection Act of 1973, as amended (Pub. L. 93-234); and the National Environmental Policy Act of 1969 (NEPA) (Pub. L. 91-190...

43 CFR 3410.0-3 - Authority.

Code of Federal Regulations, 2012 CFR

2012-10-01

... amended by section 4 of the Federal Coal Leasing Amendments Act of 1976 (30 U.S.C. 201(b)). ... Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Authority. (a) These regulations are issued under the authority of the statutes listed in § 3400.0-3 of this...

43 CFR 3410.0-3 - Authority.

Code of Federal Regulations, 2011 CFR

2011-10-01

... amended by section 4 of the Federal Coal Leasing Amendments Act of 1976 (30 U.S.C. 201(b)). ... Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Authority. (a) These regulations are issued under the authority of the statutes listed in § 3400.0-3 of this...

43 CFR 3410.0-3 - Authority.

Code of Federal Regulations, 2014 CFR

2014-10-01

... amended by section 4 of the Federal Coal Leasing Amendments Act of 1976 (30 U.S.C. 201(b)). ... Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Authority. (a) These regulations are issued under the authority of the statutes listed in § 3400.0-3 of this...

43 CFR 3410.0-3 - Authority.

Code of Federal Regulations, 2013 CFR

2013-10-01

... amended by section 4 of the Federal Coal Leasing Amendments Act of 1976 (30 U.S.C. 201(b)). ... Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Authority. (a) These regulations are issued under the authority of the statutes listed in § 3400.0-3 of this...

75 FR 65703 - Aviation Proceedings, Agreements Filed the Week Ending October 8, 2010

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-26

...: Members of the International Air Transport Association. Subject: TC3 Special Passenger Amending Resolution 010a from Korea (Rep. of) to South East Asia (except Guam, Northern Mariana Islands) (Memo 1404.... Parties: Members of the International Air Transport Association. Subject: TC3 Special Passenger Amending...

Internal initiation of influenza virus replication of viral RNA and complementary RNA in vitro.

PubMed

Zhang, Shijian; Wang, Jinlan; Wang, Qiang; Toyoda, Tetsuya

2010-12-24

Influenza virus transcription is a prototype of primer-dependent initiation. Its replication mechanism is thought to be primer-independent. The internal initiation and realignment model for influenza virus genome replication has been recently proposed (Deng, T., Vreede, F. T., and Brownlee, G. G. (2006) J. Virol. 80, 2337-2348). We obtained new results, which led us to propose a novel model for the initiation of viral RNA (vRNA) replication. In our study, we analyzed the initiation mechanisms of influenza virus vRNA and complementary RNA (cRNA) synthesis in vitro, using purified RNA polymerase (RdRp) and 84-nt model RNA templates. We found that, for vRNA → cRNA →, RdRp initiated replication from the second nucleotide of the 3'-end. Therefore, host RNA-specific ribonucleotidyltransferases are required to add one nucleotide (purine residues are preferred) to the 3'-end of vRNA to make the complete copy of vRNA. This hypothesis was experimentally proven using poly(A) polymerase. For cRNA → vRNA, the dinucleotide primer AG was synthesized from UC (fourth and fifth from the 3'-end) by RdRp pausing at the sixth U of UUU and realigning at the 3'-end of cRNA template; then RdRp was able to read through the entire template RNA. The RdRp initiation complex was not stable until it had read through the UUU of cRNA and the UUUU of vRNA at their respective 3'-ends. This was because primers overlapping with the first U of the clusters did not initiate transcription efficiently, and the initiation product of v84+G (the v84 template with an extra G at its 3'-end), AGC, realigned to the 3'-end.

Joint Battery Industry Sector Study.

DTIC Science & Technology

1994-08-31

Electric Vehicle R&D Programs ..... 122 Table 8-20 North American Nickel Cadmium R&D Playes ........................... 124 Table 8- 21 North American...in a sealed nickel cadmium battery are made of 21 I I’I non-woven (felt) nylon. In vented nickel cadmium cells, the separator is usually woven or non...and Space3 ~ ~~~Company____________ ________ ____ Table 8- 21 . North American Nickel Hydrogen R&D Players IN Duracell NASA Johnson Space Center Texas

The role of chairman and research director in influencing scholarly productivity and research funding in academic orthopaedic surgery.

PubMed

Stavrakis, Alexandra I; Patel, Ankur D; Burke, Zachary D C; Loftin, Amanda H; Dworsky, Erik M; Silva, Mauricio; Bernthal, Nicholas M

2015-10-01

The purpose of this study was to determine what orthopaedic surgery department leadership characteristics are most closely correlated with securing NIH funding and increasing scholarly productivity. Scopus database was used to identify number of publications/h-index for 4,328 faculty, department chairs (DC), and research directors (RD), listed on departmental websites from 138 academic orthopaedic departments in the United States. NIH funding data was obtained for the 2013 fiscal year. While all programs had a DC, only 46% had a RD. Of $54,925,833 in NIH funding allocated to orthopaedic surgery faculty in 2013, 3% of faculty and 31% of departments were funded. 16% of funded institutions had a funded DC whereas 65% had a funded RD. Department productivity and funding were highly correlated to leadership productivity and funding(p< 0.05). Mean funding was $1,700,000 for departments with a NIH-funded RD, $104,000 for departments with an unfunded RD, and $72,000 for departments with no RD. These findings suggest that orthopaedic department academic success is directly associated with scholarly productivity and funding of both DC and RD. The findings further highlight the correlation between a funded RD and a well-funded department. This does not hold for an unfunded RD. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

Validation of the Retinal Detachment after Open Globe Injury (RD-OGI) Score as an Effective Tool for Predicting Retinal Detachment.

PubMed

Brodowska, Katarzyna; Stryjewski, Tomasz P; Papavasileiou, Evangelia; Chee, Yewlin E; Eliott, Dean

2017-05-01

The Retinal Detachment after Open Globe Injury (RD-OGI) Score is a clinical prediction model that was developed at the Massachusetts Eye and Ear Infirmary to predict the risk of retinal detachment (RD) after open globe injury (OGI). This study sought to validate the RD-OGI Score in an independent cohort of patients. Retrospective cohort study. The predictive value of the RD-OGI Score was evaluated by comparing the original RD-OGI Scores of 893 eyes with OGI that presented between 1999 and 2011 (the derivation cohort) with 184 eyes with OGI that presented from January 1, 2012, to January 31, 2014 (the validation cohort). Three risk classes (low, moderate, and high) were created and logistic regression was undertaken to evaluate the optimal predictive value of the RD-OGI Score. A Kaplan-Meier survival analysis evaluated survival experience between the risk classes. Time to RD. At 1 year after OGI, 255 eyes (29%) in the derivation cohort and 66 eyes (36%) in the validation cohort were diagnosed with an RD. At 1 year, the low risk class (RD-OGI Scores 0-2) had a 3% detachment rate in the derivation cohort and a 0% detachment rate in the validation cohort, the moderate risk class (RD-OGI Scores 2.5-4.5) had a 29% detachment rate in the derivation cohort and a 35% detachment rate in the validation cohort, and the high risk class (RD-OGI scores 5-7.5) had a 73% detachment rate in the derivation cohort and an 86% detachment rate in the validation cohort. Regression modeling revealed the RD-OGI to be highly discriminative, especially 30 days after injury, with an area under the receiver operating characteristic curve of 0.939 in the validation cohort. Survival experience was significantly different depending upon the risk class (P < 0.0001, log-rank chi-square). The RD-OGI Score can reliably predict the future risk of developing an RD based on clinical variables that are present at the time of the initial evaluation after OGI. Copyright © 2017 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

77 FR 16988 - Protection of Stratospheric Ozone: Amendment to HFO-1234yf SNAP Rule for Motor Vehicle Air...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-23

... Protection of Stratospheric Ozone: Amendment to HFO-1234yf SNAP Rule for Motor Vehicle Air Conditioning... hydrofluoroolefin (HFO)-1234yf (2,3,3,3-tetrafluoroprop-1-ene), a substitute for ozone- depleting substances (ODSs... EPA's Stratospheric Ozone Web site at http://www.epa.gov/ozone/snap/regs . The full list of SNAP...

3 CFR - Delegation of Authority Under Section 506(a)(1) of the Foreign Assistance Act of 1961, as Amended

Code of Federal Regulations, 2014 CFR

2014-01-01

... 3 The President 1 2014-01-01 2014-01-01 false Delegation of Authority Under Section 506(a)(1) of the Foreign Assistance Act of 1961, as Amended Presidential Documents Other Presidential Documents... by the Constitution and the laws of the United States of America, including section 301 of title 3...

Valorization of a treated soil via amendments: fractionation and oral bioaccessibility of Cu, Ni, Pb, and Zn.

PubMed

Zagury, Gerald J; Rincon Bello, Jhony A; Guney, Mert

2016-04-01

The present study aims to transform a treated soil (TS) into a more desirable resource by modifying physico-chemical properties via amendments while reducing toxic metals' mobility and oral bioaccessibility. A hydrocarbon-contaminated soil submitted to treatment (TS) but still containing elevated concentrations of Cu, Ni, Pb, and Zn has been amended with compost, sand, and Al2(SO4)3 to render it usable for horticulture. Characterization and sequential extraction were performed for TS and four amended mixtures (AM1-4). P and K availability and metal bioaccessibility were investigated in TS and AM2. Amendment improved soil properties for all mixtures and yielded a usable product (AM2 20 % TS, 49 % compost, 30 % sand, 1 % Al2(SO4)3) satisfying regulatory requirements except for Pb content. In particular, AM2 had improved organic matter (OM) and cation exchange capacity (CEC), highly increased P and K availability, and reduced total metal concentrations. Furthermore, amendment decreased metal mobile fraction likely to be plant-available (in mg kg(-1), assumed as soluble/exchangeable + carbonates fractions). For AM2, estimated Pb bioavailability decreased from 1.50 × 10(3) mg kg(-1) (TS) to 238 mg kg(-1) (52.4 % (TS) to 34.2 %). Bioaccessible concentrations of Cu, Ni, and Zn (mg kg(-1)) were lower in AM2 than in TS, but there was no significant decrease for Pb. The results suggest that amendment improved soil by modifying its chemistry, resulting in lower metal mobile fraction (in %, for Cu and Zn) and bioaccessibility (in %, for Cu only). Amending soils having residual metal contamination can be an efficient valorization method, indicating potential for reducing treatment cost and environmental burden by rendering disposal/additional treatment unnecessary. Further studies including plant bioavailability are recommended to confirm results.

41 CFR 102-73.100 - Is the Competition in Contracting Act of 1984, as amended (CICA), applicable to lease acquisition?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Is the Competition in Contracting Act of 1984, as amended (CICA), applicable to lease acquisition? 102-73.100 Section 102-73.100... Contracting Act of 1984 § 102-73.100 Is the Competition in Contracting Act of 1984, as amended (CICA...

5 CFR 1630.13 - Procedures for review of determination to deny access to or amendment of records.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Procedures for review of determination to deny access to or amendment of records. 1630.13 Section 1630.13 Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD PRIVACY ACT REGULATIONS § 1630.13 Procedures for review of determination to deny access to or amendment of records. ...

17 CFR 260.7a-5 - Filing of amendments; number of copies.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Filing of amendments; number of copies. 260.7a-5 Section 260.7a-5 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, TRUST INDENTURE ACT OF 1939 Rules Under Section 307 § 260.7a-5 Filing of amendments; number of copie...

17 CFR 260.7a-5 - Filing of amendments; number of copies.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Filing of amendments; number of copies. 260.7a-5 Section 260.7a-5 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, TRUST INDENTURE ACT OF 1939 Rules Under Section 307 § 260.7a-5 Filing of amendments; number of copie...

17 CFR 260.7a-5 - Filing of amendments; number of copies.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Filing of amendments; number of copies. 260.7a-5 Section 260.7a-5 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, TRUST INDENTURE ACT OF 1939 Rules Under Section 307 § 260.7a-5 Filing of amendments; number of copie...

17 CFR 260.7a-5 - Filing of amendments; number of copies.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Filing of amendments; number of copies. 260.7a-5 Section 260.7a-5 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, TRUST INDENTURE ACT OF 1939 Rules Under Section 307 § 260.7a-5 Filing of amendments; number of copie...

78 FR 4505 - Options Price Reporting Authority; Notice of Filing of Proposed Amendment to the Plan for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-22

... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-68655; File No. SR-OPRA-2012-07] Options Price Reporting Authority; Notice of Filing of Proposed Amendment to the Plan for Reporting of Consolidated Options Last Sale Reports and Quotation Information To Amend Section 3.5 of the OPRA Plan January 15, 2013. Pursuant to Section 11A of the...