Sample records for licensed direct marking

  1. Predicting complex syntactic structure in real time: Processing of negative sentences in Russian.

    PubMed

    Kazanina, Nina

    2017-11-01

    In Russian negative sentences the verb's direct object may appear either in the accusative case, which is licensed by the verb (as is common cross-linguistically), or in the genitive case, which is licensed by the negation (Russian-specific "genitive-of-negation" phenomenon). Such sentences were used to investigate whether case marking is employed for anticipating syntactic structure, and whether lexical heads other than the verb can be predicted on the basis of a case-marked noun phrase. Experiment 1, a completion task, confirmed that genitive-of-negation is part of Russian speakers' active grammatical repertoire. In Experiments 2 and 3, the genitive/accusative case manipulation on the preverbal object led to shorter reading times at the negation and verb in the genitive versus accusative condition. Furthermore, Experiment 3 manipulated linear order of the direct object and the negated verb in order to distinguish whether the abovementioned facilitatory effect was predictive or integrative in nature, and concluded that the parser actively predicts a verb and (otherwise optional) negation on the basis of a preceding genitive-marked object. Similarly to a head-final language, case-marking information on preverbal noun phrases (NPs) is used by the parser to enable incremental structure building in a free-word-order language such as Russian.

  2. 78 FR 35990 - All Operating Boiling-Water Reactor Licensees With Mark I And Mark II Containments; Docket Nos...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-14

    ... NUCLEAR REGULATORY COMMISSION [NRC-2013-0128] All Operating Boiling-Water Reactor Licensees With Mark I And Mark II Containments; Docket Nos. (As Shown In Attachment 1), License Nos. (As Shown In Attachment 1), EA-13-109; Order Modifying Licenses With Regard to Reliable Hardened Containment Vents Capable of Operation Under Severe Accident...

  3. 75 FR 55366 - In the Matter of Mark M. Ficek; Order Prohibiting Involvement in NRC-Licensed Activities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-10

    ... (Effective Immediately) Mr. Mark M. Ficek is the President, owner, and former radiation safety officer (RSO... new radiation safety officer, and due to expire on February 28, 2016. The license authorizes Mattingly... assessing Mattingly's entire radiation safety program, providing radiation safety training to the Mattingly...

  4. 22 CFR 123.24 - Shipments by U.S. Postal Service.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... with this subchapter by clearly marking on the package “This export is subject to the controls of the...) The export of any technical data using a license in this subchapter by the U.S. Postal Service must be... either a license or exemption, must certify, by clearly marking on the package, “This export is subject...

  5. 19 CFR 112.30 - Suspension or revocation of license.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Suspension or revocation of license. 112.30... Suspension or revocation of license. (a) Grounds for suspension or revocation of licenses. The port director... produced upon demand; (2) His vehicle or vessel is not properly marked, as required by § 112.27; (3) The...

  6. 36 CFR 25.2 - License.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Director of the National Park Service, who will likewise supervise the marking of examination papers and the rating of applicants. (d) The names of applicants who successfully pass the examination will be...) , having successfully passed the examination prescribed for license, is hereby licensed to offer his...

  7. UID.. .Now That's Gonna Leave A Mark

    NASA Technical Reports Server (NTRS)

    Schramm, Fred

    2006-01-01

    Since 1975 bar codes on products at the retail counter have been accepted as the standard for entering product identity for price determination. Since the beginning of the 21st century, the Data Matrix symbol has become accepted as the bar code format that is marked directly on a part, assembly or product that is durable enough to identify that item for its lifetime. NASA began the studies for direct part marking Data Matrix symbols on parts during the Return to Flight activities after the Challenger Accident. Over the 20 year period that has elapsed since Challenger, a mountain of studies, analyses and focused problem solutions developed by and for NASA have brought about world changing results. NASA Technical Standard 6002 and NASA Handbook 6003 for Direct Part Marking Data Matrix Symbols on Aerospace Parts have formed the basis for most other standards on part marking internationally. NASA and its commercial partners have developed numerous products and methods that addressed the difficulties of collecting part identification in aerospace operations. These products enabled the marking of Data Matrix symbols in virtually every situation and the reading of symbols at great distances, severe angles, under paint and in the dark without a light. Even unmarkable delicate parts now have a process to apply a chemical mixture, recently trademarked as Nanocodes, that can be converted to Data Matrix information through software. The accompanying intellectual property is protected by ten patents, several of which are licensed. Direct marking Data Matrix on NASA parts dramatically decreases data entry errors and the number of parts that go through their life cycle marked, two major threats to sound configuration management and flight safety. NASA is said to only have people and stuff with information connecting them. Data Matrix is one of the most significant improvements since Challenger to the safety and reliability of that connection.

  8. UID...Leaving Its Mark on the Universe

    NASA Technical Reports Server (NTRS)

    Schramm, Harry F., Jr.

    2008-01-01

    Since 1975 bar codes on products at the retail counter have been accepted as the standard for entering product identity for price determination. Since the beginning of the 21 st century, the Data Matrix symbol has become accepted as the bar code format that is marked directly on a part, assembly or product that is durable enough to identify that item for its lifetime. NASA began the studies for direct part marking Data Matrix symbols on parts during the Return to Flight activities after the Challenger Accident. Over the 20 year period that has elapsed since Challenger, a mountain of studies, analyses and focused problem solutions developed by and for NASA have brought about world changing results. NASA Technical Standard 6002 and NASA Handbook 6003 for Direct Part Marking Data Matrix Symbols on Aerospace Parts have formed the basis for most other standards on part marking internationally. NASA and its commercial partners have developed numerous products and methods that addressed the difficulties of collecting part identification in aerospace operations. These products enabled the marking of Data Matrix symbols in virtually every situation and the reading of symbols at great distances, severe angles, under paint and in the dark without a light. Even unmarkable delicate parts now have a process to apply a chemical mixture, recently trademarked as Nanocodes, that can be converted to Data Matrix information through software. The accompanying intellectual property is protected by ten patents, several of which are licensed. Direct marking Data Matrix on NASA parts dramatically decreases data entry errors and the number of parts that go through their life cycle unmarked, two major threats to sound configuration management and flight safety. NASA is said to only have people and stuff with information connecting them. Data Matrix is one of the most significant improvements since Challenger to the safety and reliability of that connection.

  9. UID...Now That's Gonna Leave A Mark

    NASA Technical Reports Server (NTRS)

    Schramm, Harry F., Jr.

    2007-01-01

    Since 1975 bar codes on products at the retail counter have been accepted as the standard for entering product identity for price determination. Since the beginning of the 21st century, the Data Matrix symbol has become accepted as the bar code format that is marked directly on a part, assembly or product that is durable enough to identify that item for its lifetime. NASA began the studies for direct part marking Data Matrix symbols on parts during the Return to Flight activities after the Challenger Accident. Over the 20 year period that has elapsed since Challenger, a mountain of studies, analyses and focused problem solutions developed by and for NASA have brought about world changing results. NASA Technical Standard 6002 and NASA Handbook 6003 for Direct Part Marking Data Matrix Symbols on Aerospace Parts have formed the basis for most other standards on part marking internationally. NASA and its commercial partners have developed numerous products and methods that addressed the difficulties of collecting part identification in aerospace operations. These products enabled the marking of Data Matrix symbols in virtually every situation and the reading of symbols at great distances, severe angles, under paint and in the dark without a light. Even unmarkable delicate parts now have a process to apply a chemical mixture, recently trademarked as Nanocodes, that can be converted to Data Matrix information through software. The accompanying intellectual property is protected by ten patents, several of which are licensed. Direct marking Data Matrix on NASA parts dramatically decreases data entry errors and the number ofparts that go through their life cycle unmarked, two major threats to sound configuration management and flight safety. NASA is said to only have people and stuff with information connecting them. Data Matrix is one of the most significant improvements since Challenger to the safety and reliability of that connection.

  10. UID...Now That's Gonna Leave a Mark

    NASA Technical Reports Server (NTRS)

    Schramm, Harry F.

    2008-01-01

    Since 1975 bar codes on products at the retail counter have been accepted as the standard for entering product identity for price determination. Since the beginning of the 21st century, the Data Matrix symbol has become accepted as the bar code format that is marked directly on a part, assembly or product that is durable enough to identify that item for its lifetime. NASA began the studies for direct part marking Data Matrix symbols on parts during the Return to Flight activities after the Challenger Accident. Over the 20 year period that has elapsed since Challenger, a mountain of studies, analyses and focused problem solutions developed by and for NASA have brought about world changing results. NASA Technical Standard 6002 and NASA Handbook 6003 for Direct Part Marking Data Matrix Symbols on Aerospace Parts have formed the basis for most other standards on part marking internationally. NASA and its commercial partners have developed numerous products and methods that addressed the difficulties of collecting part identification in aerospace operations. These products enabled the marking of Data Matrix symbols in virtually every situation and the reading of symbols at great distances, severe angles, under paint and in the dark without a light. Even unmarkable delicate parts now have a process to apply a chemical mixture, recently trademarked as Nanocodes, that can be converted to Data Matrix information through software. The accompanying intellectual property is protected by ten patents, several of which are licensed. Direct marking Data Matrix on NASA parts dramatically decreases data entry errors and the number of parts that go through their life cycle unmarked, two major threats to sound configuration management and flight safety. NASA is said to only have people and stuff with information connecting them. Data Matrix is one of the most significant improvements since Challenger to the safety and reliability of that connection.

  11. UID....Now That's Gonna Leave A Mark

    NASA Technical Reports Server (NTRS)

    Schramm, Harry F., Jr.

    2008-01-01

    Since 1975 bar codes on products at the retail counter have been accepted as the standard for entering product identity for price determination. Since the beginning of the 21 st century, the Data Matrix symbol has become accepted as the bar code format that is marked directly on a part, assembly or product that is durable enough to identify that item for its lifetime. NASA began the studies for direct part marking Data Matrix symbols on parts during the Return to Flight activities after the Challenger Accident. Over the 20 year period that has elapsed since Challenger, a mountain of studies, analyses and focused problem solutions developed by and for NASA have brought about world changing results. NASA Technical Standard 6002 and NASA Handbook 6003 for Direct Part Marking Data Matrix Symbols on Aerospace Parts have formed the basis for most other standards on part marking internationally. NASA and its commercial partners have developed numerous products and methods that addressed the difficulties of collecting part identification in aerospace operations. These products enabled the marking of Data Matrix symbols in virtually every situation and the reading of symbols at great distances, severe angles, under paint and in the dark without a light. Even unmarkable delicate parts now have a process to apply a chemical mixture, recently trademarked as Nanocodes, that can be converted to Data Matrix information through software. The accompanying intellectual property is protected by ten patents, several of which are licensed. Direct marking Data Matrix on NASA parts dramatically decreases data entry errors and the number of parts that go through their life cycle unmarked, two major threats to sound configuration management and flight safety. NASA is said to only have people and stuff with information connecting them. Data Matrix is one of the most significant improvements since Challenger to the safety and reliability of that connection.

  12. NASA Technologies for Product Identification

    NASA Technical Reports Server (NTRS)

    Schramm, Fred, Jr.

    2006-01-01

    Since 1975 bar codes on products at the retail counter have been accepted as the standard for entering product identity for price determination. Since the beginning of the 21st century, the Data Matrix symbol has become accepted as the bar code format that is marked directly on a part, assembly or product that is durable enough to identify that item for its lifetime. NASA began the studies for direct part marking Data Matrix symbols on parts during the Return to Flight activities after the Challenger Accident. Over the 20 year period that has elapsed since Challenger, a mountain of studies, analyses and focused problem solutions developed by and for NASA have brought about world changing results. NASA Technical Standard 6002 and NASA Handbook 6003 for Direct Part Marking Data Matrix Symbols on Aerospace Parts have formed the basis for most other standards on part marking internationally. NASA and its commercial partners have developed numerous products and methods that addressed the difficulties of collecting part identification in aerospace operations. These products enabled the marking of Data Matrix symbols in virtually every situation and the reading of symbols at great distances, severe angles, under paint and in the dark without a light. Even unmarkable delicate parts now have a process to apply a chemical mixture called NanocodesTM that can be converted to a Data Matrix. The accompanying intellectual property is protected by 10 patents, several of which are licensed. Direct marking Data Matrix on NASA parts virtually eliminates data entry errors and the number of parts that go through their life cycle unmarked, two major threats to sound configuration management and flight safety. NASA is said to only have people and stuff with information connecting them. Data Matrix is one of the most significant improvements since Challenger to the safety and reliability of that connection. This presentation highlights the accomplishments of NASA in its efforts to develop technologies for automatic identification, its efforts to implement them and its vision on their role in space.

  13. 76 FR 17862 - Ocean Transportation Intermediary License; Applicants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-31

    ..., President/Secretary, (Qualifying Individual), Application Type: New OFF License. Wilson Transportation, Inc. (OFF), 16226 Foster Street, Overland Park, KS 66085, Officers: Jerry G. Owen, Vice President International, (Qualifying Individual), Mark A. Wilson, President/Treasurer/Secretary, Application Type: New OFF...

  14. Reducing the cost of headache medication.

    PubMed

    Solomon, Glen D

    2009-06-01

    Although medication costs make up one of the smallest portions of the overall expense of headache care, it is the segment of expense that often impacts the patient most directly. The advent of triptans marked a major advance in migraine therapy, but their high cost has limited their widespread use. Four options can be considered as potential means to reduce the cost of triptans. These include compulsory licensing, exclusive contracting, over-the-counter -availability, and the introduction of generic triptans. Each method impacts the consumer, third-party payer, or pharmaceutical company in a different manner.

  15. 32 CFR 37.850 - Should I require recipients to mark data?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... from disclosure with a legend identifying the data as licensed data subject to use, release, or... 32 National Defense 1 2013-07-01 2013-07-01 false Should I require recipients to mark data? 37.850... Intellectual Property § 37.850 Should I require recipients to mark data? To protect the recipient's interests...

  16. 32 CFR 37.850 - Should I require recipients to mark data?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... from disclosure with a legend identifying the data as licensed data subject to use, release, or... 32 National Defense 1 2012-07-01 2012-07-01 false Should I require recipients to mark data? 37.850... Intellectual Property § 37.850 Should I require recipients to mark data? To protect the recipient's interests...

  17. 77 FR 60434 - Ocean Transportation Intermediary License Applicants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-03

    ..., Washington, DC 20573, by telephone at (202) 523-5843 or by email at [email protected] . AAB Logistics, LLC (NVO... Logistics, Inc. (NVO & OFF), 4666 Faries Parkway, Decatur, IL 62526, Officers: Mark D. Schweitzer, Vice... Gurdian, President, Application Type: New NVO & OFF License. J&T Logistics Inc. dba EDI Logistics Group...

  18. [Spanish medical and psycho-technical model within the context of the second directive (91/439/EEC). Results when conducted on a specific group of drivers (45-70 age range)].

    PubMed

    Montoro González, Luis; Mirabet Lis, Enrique

    2003-01-01

    Directive 91/439/EEC marked the start of what the European Economic Community driver's license is going to be like at some time in the future. However, differences currently exist with regard to the driver license eligibility requirements and renewal periods. This study provides the results of the physical and psychotechnical exam conducted on 606 drivers of the following characteristics: both males and females, aged between 45-70, revising the group 1 (B) license, and with a renewal period of less than 5 years. Five years later some of these qualified drivers were examined again in order to check changes with regard to previous exam results. Results show that 86.47% were qualified the same; 12.21% were qualified with some restriction and 1.65% was unqualified. By age groups, it was found that the older the applicants, the lower the percentage of those qualified and the higher the percentage of those qualified with some restriction (in the 45-49 age range, 93.19% are qualified, while the percentage qualified in the 65-69 age group is 67.35%). Within five years time, 11.13% of the qualified drivers had made some change in their status (9.98% qualified with some restriction, 1.15% unqualified), significant differences also having been found by age groups (in the 45-49 age group, 6.8% had change in status compared to 18.1% in the 65-69 age group). Therefore, differences can be said to exist between the different ages and the qualifications obtained to keep a driver's license, and a significant percentage of qualified drivers undergo some change in their eligibility within a minimum five-year period.

  19. 15 CFR 748.4 - Basic guidance related to applying for a license.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION... sending of items out of the United States, except for Encryption License Arrangements (ELA) (see § 750.7(d... (Additional information) must be marked “748.4(b)(2)” to indicate that the power of attorney or other written...

  20. 15 CFR 748.4 - Basic guidance related to applying for a license.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION... sending of items out of the United States, except for Encryption License Arrangements (ELA) (see § 750.7(d... (Additional information) must be marked “748.4(b)(2)” to indicate that the power of attorney or other written...

  1. Creative Commons and Why It Should Be More Commonly Understood

    ERIC Educational Resources Information Center

    Johnson, Doug

    2009-01-01

    Authors, videographers, musicians, photographers, and almost anyone who creates materials and makes them publicly available has an alternative to standard copyright licensing: Creative Commons (CC). It is a tool that helps the creator display a licensing mark. The creator can assign a variety of rights for others to use his work--rights that are…

  2. 50 CFR 660.319 - Open access fishery gear identification and marking.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Open access fishery gear identification and marking. 660.319 Section 660.319 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT... law, the vessel's number, the commercial fishing license number, or buoy brand number; or (ii) The...

  3. 77 FR 9222 - Lock+ Hydro Friends Fund XLII, LLC; Notice of Intent To File License Application, Filing of Pre...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-16

    ... Friends Fund XLII, LLC; Notice of Intent To File License Application, Filing of Pre-Application Document.... Date Filed: December 23, 2011. d. Submitted By: Lock+ Hydro Friends Fund XLII, LLC. e. Name of Project... regulations. h. Potential Applicant Contact: Mr. Mark R. Stover, Lock+\\TM\\ Hydro Friends Fund XLII, c/o Hydro...

  4. 77 FR 16216 - Lock+ Hydro Friends Fund XLVI, LLC; Notice of Intent To File License Application, Filing of Pre...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-20

    ... Friends Fund XLVI, LLC; Notice of Intent To File License Application, Filing of Pre-Application Document.... Date Filed: February 7, 2012. d. Submitted By: Lock+ Hydro Friends Fund XLVI, LLC. e. Name of Project... regulations. h. Potential Applicant Contact: Mr. Mark R. Stover, Lock+\\TM\\ Hydro Friends Fund XLVI, c/o Hydro...

  5. 77 FR 16217 - Lock+ Hydro Friends Fund XXXIX, LLC; Notice of Intent To File License Application, Filing of Pre...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-20

    ... Friends Fund XXXIX, LLC; Notice of Intent To File License Application, Filing of Pre-Application Document.... Date Filed: February 7, 2012. d. Submitted by: Lock+ Hydro Friends Fund XXXIX, LLC. e. Name of Project... Commission's regulations. h. Potential Applicant Contact: Mr. Mark R. Stover, Lock+\\TM\\ Hydro Friends Fund...

  6. An autopsy case of fatal acute peritonitis complicated by illegal acupuncture therapy.

    PubMed

    Kim, DongJa; Lee, SangHan

    2017-07-01

    Acupuncture is an alternative medical therapy and widely practiced in Northeast Asia. Although it is known as a safe procedure, complications including infection, pneumothorax, hemorrhage, and cardiac tamponade have been reported. The authors present a rare case of fatal acute peritonitis due to penetration of acupuncture needles directly into the abdominal and pelvic cavity. The victim was a 55-year-old woman who had a recent history of chemo-radiotherapy due to breast cancer. She was collapsed three days after receiving acupuncture. She had symptoms of fever and chilling sensation, general myalgia, and vomiting during three days. The autopsy revealed several needle marks in the lower abdomen and 180ml of bloody exudate in the abdominal cavity. There was no visible intestinal perforation, but hemorrhagic foci in the mesentery and paracolic area of sigmoid colon were noted. The deepest portion was 13.5cm from the needle marks on the abdominal skin. The practitioner had not a Chinese medical license. He was accused of illegal medical practice and manslaughter. Acute peritonitis associated with acupuncture might be caused by inadequate sterilization of skin and needle itself and/or direct mesentery injury. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. 77 FR 23241 - Lock+ Hydro Friends Fund XXX, LLC; Notice of Intent To File License Application, Filing of Pre...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ... Friends Fund XXX, LLC; Notice of Intent To File License Application, Filing of Pre-Application Document.... Date Filed: February 20, 2012. d. Submitted By: Lock+ Hydro Friends Fund XXX, LLC. e. Name of Project... Applicant Contact: Mr. Mark R. Stover, Lock+\\TM\\ Hydro Friends Fund XXX, c/o Hydro Green Energy, LLC, 900...

  8. 22 CFR 123.24 - Shipments by U.S. Postal Service.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... subchapter by clearly marking on the package “This export is subject to the controls of the ITAR, 22 CFR... any technical data using a license in this subchapter by the U.S. Postal Service must be notified... or exemption, must certify, by clearly marking on the package, “This export is subject to the...

  9. 22 CFR 123.24 - Shipments by U.S. Postal Service.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... subchapter by clearly marking on the package “This export is subject to the controls of the ITAR, 22 CFR... any technical data using a license in this subchapter by the U.S. Postal Service must be notified... or exemption, must certify, by clearly marking on the package, “This export is subject to the...

  10. 22 CFR 123.24 - Shipments by U.S. Postal Service.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... subchapter by clearly marking on the package “This export is subject to the controls of the ITAR, 22 CFR... any technical data using a license in this subchapter by the U.S. Postal Service must be notified... or exemption, must certify, by clearly marking on the package, “This export is subject to the...

  11. 22 CFR 123.24 - Shipments by U.S. Postal Service.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... subchapter by clearly marking on the package “This export is subject to the controls of the ITAR, 22 CFR... any technical data using a license in this subchapter by the U.S. Postal Service must be notified... or exemption, must certify, by clearly marking on the package, “This export is subject to the...

  12. 78 FR 15383 - Approval of Direct Transfer of Licenses and Issuance of License Amendment To Effectuate Such...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-11

    ... NUCLEAR REGULATORY COMMISSION [Docket Nos. 70-7003 and 70-7004; NRC-2010-0355] Approval of Direct... Operating, LLC AGENCY: Nuclear Regulatory Commission. ACTION: Notice of approval of direct transfer of control and issuance of license amendments to effectuate such transfers. SUMMARY: The U.S. Nuclear...

  13. 10 CFR 32.29 - Conditions of licenses issued under § 32.26: Quality control, labeling, and reports of transfer.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... standards approved by the Commission; (b) Label or mark each detector and its point-of-sale package so that: (1) Each detector has a durable, legible, readily visible label or marking on the external surface of the detector containing: (i) The following statement: “CONTAINS RADIOACTIVE MATERIAL”; (ii) The name...

  14. 10 CFR 32.29 - Conditions of licenses issued under § 32.26: Quality control, labeling, and reports of transfer.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... standards approved by the Commission; (b) Label or mark each detector and its point-of-sale package so that: (1) Each detector has a durable, legible, readily visible label or marking on the external surface of the detector containing: (i) The following statement: “CONTAINS RADIOACTIVE MATERIAL”; (ii) The name...

  15. 10 CFR 32.29 - Conditions of licenses issued under § 32.26: Quality control, labeling, and reports of transfer.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... standards approved by the Commission; (b) Label or mark each detector and its point-of-sale package so that: (1) Each detector has a durable, legible, readily visible label or marking on the external surface of the detector containing: (i) The following statement: “CONTAINS RADIOACTIVE MATERIAL”; (ii) The name...

  16. 10 CFR 32.29 - Conditions of licenses issued under § 32.26: Quality control, labeling, and reports of transfer.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... standards approved by the Commission; (b) Label or mark each detector and its point-of-sale package so that: (1) Each detector has a durable, legible, readily visible label or marking on the external surface of the detector containing: (i) The following statement: “CONTAINS RADIOACTIVE MATERIAL”; (ii) The name...

  17. Commercialization of LARC(TradeMark)-SI Polyimide Technology

    NASA Technical Reports Server (NTRS)

    Bryant, Robert G.

    2008-01-01

    LARC(TradeMark)-SI, Langley Research Center-Soluble Imide, was developed in 1992. This new polyimide won a 1995 Research and Development 100 Award, with the first patent issuing in 1997 and subsequent issued patents in 1998 and 2000. Currently, this polymer has been successfully licensed by NASA, and has generated revenues in excess of 1.4 million dollars. This might seem insignificant in comparison to industrially developed technology, where the customer is understood, technologies that use a novel assembly of commercial off the shelf (COTS) components, or software patents and "method based" innovations that do not require any material beyond labor, as examples. However, consider that LARC(TradeMark)-SI competes in areas currently dominated by traditional materials at a cost disadvantage ($350/lb) and that the physical-mechanical properties of LARC(TradeMark)-SI are similar to other high performance polymers. Indeed the success of this particular polymer was due to many factors and many lessons learned to the point that the invention was the most important, but least significant part in the commercialization of this material. This brief paper outlines the significant factors that occurred to make this technology available for the public access and application development that led to the licensing success of this material.

  18. 75 FR 51852 - Notice of Intent To Grant Partially Exclusive License

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-23

    ... Shear Stress and Gravity'' to Regenetech, Inc., having its principal place of business in Houston, Texas... applications for cosmetics, topical treatment of burns, scars, stretch marks, acne and joint pain. The patent...

  19. Advanced Q-switched DPSS lasers for ID-card marking

    NASA Astrophysics Data System (ADS)

    Hertwig, Michael; Paster, Martin; Terbrueggen, Ralf

    2008-02-01

    Increased homeland security concerns across the world have generated a strong demand for forgery-proof ID documents. Manufacturers currently employ a variety of high technology techniques to produce documents that are difficult to copy. However, production costs and lead times are still a concern when considering any possible manufacturing technology. Laser marking has already emerged as an important tool in the manufacturer's arsenal, and is currently being utilized to produce a variety of documents, such as plastic ID cards, drivers' licenses, health insurance cards and passports. The marks utilized can range from simple barcodes and text to high resolution, true grayscale images. The technical challenges posed by these marking tasks include delivering adequate mark legibility, minimizing substrate burning or charring, accurately reproducing grayscale data, and supporting the required process throughput. This article covers the advantages and basic requirements on laser marking of cards and reviews how laser output parameters affect marking quality, speed and overall process economics.

  20. 77 FR 5460 - Federal Firearms License Proceedings-Hearings (2008R-15P)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-03

    ... material that is confidential under law (e.g., trade secrets, processes, etc.). Any portion of a comment... shall be prominently marked ``confidential'' at the top of each page. Confidential information will be...

  1. 78 FR 18999 - Prospective Grant of Start-Up Exclusive License: Photosensitizing Antibody-Fluorophore Conjugates...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-28

    .... Binding of such conjugates to targeted cancer cells followed by irradiation with near infrared light (NIR... more anti-cancer agents following the irradiation step. This is achieved by the markedly rapid...

  2. SOME DESIGN ISSUES IN PHASE 2B VERSUS PHASE 3 PREVENTION TRIALS FOR TESTING EFFICACY OF PRODUCTS OR CONCEPTS

    PubMed Central

    Gilbert, Peter B.

    2009-01-01

    SUMMARY After one or more Phase 2 trials show that a candidate preventive vaccine induces immune responses that putatively protect against an infectious disease for which there is no licensed vaccine, the next step is to evaluate the efficacy of the candidate. The trial-designer faces the question of what is the optimal size of the initial efficacy trial? Part of the answer will entail deciding between a large Phase 3 licensure trial or an intermediate-sized Phase 2b screening trial, the latter of which may be designed to directly contribute to the evidence-base for licensing the candidate, or, to test a scientific concept for moving the vaccine field forward, acknowledging that the particular candidate will never be licensable. Using the HIV vaccine field as a case study, we describe distinguishing marks of Phase 2b and Phase 3 prevention efficacy trials, and compare the expected utility of these trial types using Pascal’s decision-theoretic framework. By integrating values/utilities on (1) Correct or incorrect conclusions resulting from the trial; (2) Timeliness of obtaining the trial results; (3) Precision for estimating the intervention effect; and (4) Resources expended; this decision framework provides a more complete approach to selecting the optimal efficacy trial size than a traditional approach that is based primarily on power calculations. Our objective is to help inform the decision-process for planning an initial efficacy trial design. PMID:20419758

  3. Completed egoism and intended altruism boost healthy food choices.

    PubMed

    Weibel, Christian; Messner, Claude; Brügger, Adrian

    2014-06-01

    Based on the self-licensing literature and goal theory, we expected and found that completed (im)moral actions lead to markedly different food choices (Studies 1 & 2) than intended (im)moral actions (Study 2). In Study 1, people more often chose healthy over unhealthy food options when they recalled a completed egoistic action than when they recalled a completed altruistic action. Study 2 confirmed this finding and furthermore showed that the self-licensing effect in food choices is moderated by the action stage (completed versus intended) of the moral or immoral action. This article extends the existing self-licensing literature and opens up new perspectives for changing consumers' food consumption behavior. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. Benefit from NASA

    NASA Image and Video Library

    2004-01-08

    Research at NASA's Marshall Space Flight Center has resulted in a system for reading hidden identification codes using a hand-held magnetic scanner. It's an invention that could help businesses improve inventory management, enhance safety, improve security, and aid in recall efforts if defects are discovered. Two-dimensional Data Matrix symbols consisting of letters and numbers permanently etched on items for identification and resembling a small checkerboard pattern are more efficient and reliable than traditional bar codes, and can store up to 100 times more information. A team led by Fred Schramm of the Marshall Center's Technology Transfer Department, in partnership with PRI,Torrance, California, has developed a hand-held device that can read this special type of coded symbols, even if covered by up to six layers of paint. Before this new technology was available, matrix symbols were read with optical scanners, and only if the codes were visible. This latest improvement in digital Data Matrix technologies offers greater flexibility for businesses and industries already using the marking system. Paint, inks, and pastes containing magnetic properties are applied in matrix symbol patterns to objects with two-dimensional codes, and the codes are read by a magnetic scanner, even after being covered with paint or other coatings. The ability to read hidden matrix symbols promises a wide range of benefits in a number of fields, including airlines, electronics, healthcare, and the automotive industry. Many industries would like to hide information on a part, so it can be read only by the party who put it there. For instance, the automotive industry uses direct parts marking for inventory control, but for aesthetic purposes the marks often need to be invisible. Symbols have been applied to a variety of materials, including metal, plastic, glass, paper, fabric and foam, on everything from electronic parts to pharmaceuticals to livestock. The portability of the hand-held scanner makes work faster and easier. It reads marks in darkness, under bright light that might interfere with optical reading of visible marks, and can detect symbols obscured by discoloration or contamination. Through a license with NASA, another partner, Robotic Vision Systems, Inc., of Nashua, New Hampshire, will sell the scanner on the commercial market. NASA continues to seek additional companies to license the product. Joint efforts by Marshall researchers and industry partners are aimed at improving dentification technology as part of NASA's program to better life on Earth through technology designed for the space program. In this photo, Don Roxby, Robotic Vision Systems, Inc., (left)demonstrates the magnetic handheld scanner for Fred Schramm, (Right) MSFC Technology Transfer Department.

  5. 9 CFR 2.6 - Annual license fees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... method used to calculate the license fee. All initial license and changed class of license fees must be... research facilities, dealers, exhibitors, retail pet stores, and persons for use as pets, directly or through an auction sale, by the dealer or applicant during his or her preceding business year (calendar or...

  6. 47 CFR 5.51 - Eligibility of license.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Eligibility of license. 5.51 Section 5.51...) Applications and Licenses § 5.51 Eligibility of license. (a) Authorizations for stations in the Experimental... for scientific or technical operation data directly related to a use of radio not provided by existing...

  7. Night-time pedestrian conspicuity: effects of clothing on drivers' eye movements.

    PubMed

    Wood, Joanne M; Tyrrell, Richard A; Lacherez, Philippe; Black, Alex A

    2017-03-01

    Drivers' responses and eye movements were assessed as they approached pedestrians at night in order to explore the relative conspicuity benefits of different configurations of retroreflective markings. Eye movements were recorded using an ASL Mobile Eye (Applied Science Technologies, www.asleyetracking.com) from 14 young licensed drivers (M = 24.1 ± 6.4 years) as they drove along a closed-road circuit at night. At two locations, pedestrians walked in place facing either towards or away from the road. Pedestrians wore black clothing with a standard retroreflective vest either alone or with additional retroreflective markers positioned in a configuration conveying biological motion (biomotion). Drivers responded when they recognised that a pedestrian was present and again when they identified the direction the pedestrian was facing. Drivers recognised pedestrians from a significantly greater distance (p < 0.05) when the pedestrian's clothing included the biomotion configuration (319.1 m) than when the biomotion markings were absent (184.5 m). Further, the drivers recognised the direction that the pedestrian faced from a longer distance when biomotion markings were present (215.4 m vs 95.6 m). Eye movement data suggested that the biomotion configuration attracted drivers' attention significantly sooner than the vest (time to first fixation: 1.1 vs 3.5 s), that drivers fixated on pedestrians wearing biomotion for significantly less time prior to responding (3.4 s vs 6.1 s), and the time to first recognise a pedestrian was approximately half that for biomotion compared to vest (6.4 vs 13.9 s). Adding biomotion reflectors to the vest facilitated earlier recognition of pedestrians and faster identification of the direction that the pedestrian faced. These findings confirm that the conspicuity advantages of biomotion configurations on pedestrians at night result in part from drivers fixating pedestrians earlier and more efficiently. © 2017 The Authors Ophthalmic & Physiological Optics © 2017 The College of Optometrists.

  8. 75 FR 24938 - City of Hamilton, Ohio American Municipal Power, Inc.; Notice of Application for Transfer of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-06

    ...) and American Municipal Power, Inc. (AMP) filed an application for a partial transfer of license of the... to Hamilton and AMP. Applicants' Contacts: City of Hamilton--Mr. Mark Brandenburger, City Manager...

  9. 40 CFR 95.2 - Petition for mandatory license.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... by the grant of the license to which the petition is directed. (4) Each petition must contain a... unavailability of a mandatory patent license may result in a substantial lessening of competition or a tendency...

  10. Diverse mitotic functions of the cytoskeletal cross-linking protein Shortstop suggest a role in Dynein/Dynactin activity.

    PubMed

    Dewey, Evan B; Johnston, Christopher A

    2017-09-15

    Proper assembly and orientation of the bipolar mitotic spindle is critical to the fidelity of cell division. Mitotic precision fundamentally contributes to cell fate specification, tissue development and homeostasis, and chromosome distribution within daughter cells. Defects in these events are thought to contribute to several human diseases. The underlying mechanisms that function in spindle morphogenesis and positioning remain incompletely defined, however. Here we describe diverse roles for the actin-microtubule cross-linker Shortstop (Shot) in mitotic spindle function in Drosophila Shot localizes to mitotic spindle poles, and its knockdown results in an unfocused spindle pole morphology and a disruption of proper spindle orientation. Loss of Shot also leads to chromosome congression defects, cell cycle progression delay, and defective chromosome segregation during anaphase. These mitotic errors trigger apoptosis in Drosophila epithelial tissue, and blocking this apoptotic response results in a marked induction of the epithelial-mesenchymal transition marker MMP-1. The actin-binding domain of Shot directly interacts with Actin-related protein-1 (Arp-1), a key component of the Dynein/Dynactin complex. Knockdown of Arp-1 phenocopies Shot loss universally, whereas chemical disruption of F-actin does so selectively. Our work highlights novel roles for Shot in mitosis and suggests a mechanism involving Dynein/Dynactin activation. © 2017 Dewey and Johnston. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  11. 50 CFR 32.40 - Massachusetts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... applicable hunting licenses, permits, stamps, and a photographic identification while hunting on the refuge...). 8. We prohibit the marking any tree or other refuge feature with flagging, paint, reflective... tree or hunting from any tree into which a nail, spike, screw, or other object has been driven (see...

  12. 75 FR 29763 - Government-Owned Inventions; Availability for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-27

    ... commercialization of results of federally-funded research and development. Foreign patent applications are filed on... patent applications. Simple, Quantitative and Highly Specific Antibody Detection of Lyme Disease... markedly out-performed the C6 ELISA test (currently the most sensitive test available, with 76% sensitivity...

  13. 9 CFR 115.2 - Inspections of biological products.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... United States veterinary license number or a United States veterinary permit number or other mark...) When notified to stop distribution and sale of a serial or subserial of a veterinary biological product by the Secretary, veterinary biologics licensees or permittees shall: (1) Stop the preparation...

  14. 9 CFR 115.2 - Inspections of biological products.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... United States veterinary license number or a United States veterinary permit number or other mark...) When notified to stop distribution and sale of a serial or subserial of a veterinary biological product by the Secretary, veterinary biologics licensees or permittees shall: (1) Stop the preparation...

  15. 75 FR 25257 - Ocean Transportation Intermediary License Applicants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    .../Treasurer/Secretary (Qualifying Individual), Application Type: New NVO License. Direct Service Inc. dba...: Chi Hao (Steve) Hung, President (Qualifying Individual), Application Type: Trade Name Change. GTS... President (Qualifying Individual), Erick S. Cicala, President, Application Type: New Off & NVO License. Lopa...

  16. 42 CFR 431.706 - Composition of licensing board.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Licensing Nursing Home Administrators § 431.706 Composition of licensing board. (a) The board must be... institutions may not have a direct financial interest in any nursing home. (b) For purposes of this section, nursing home administrators are considered representatives of institutions. ...

  17. 78 FR 63365 - Determination With Respect to the Child Soldiers Prevention Act of 2008

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ... provision of International Military Education and Training (IMET) and nonlethal Excess Defense Articles, and the issuance of licenses for direct commercial sales of nonlethal defense articles; and to waive in... for the issuance of licenses for direct commercial sales of nonlethal defense articles, provision of...

  18. 27 CFR 555.123 - Records maintained by licensed manufacturers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... marks of identification. (3) Quantity (applicable quantity units, such as pounds of explosives, number...), blasting agents (ba), detonators (det), display fireworks (df), etc.) and size (length and diameter or... or brand name of manufacturer or name of importer, as applicable, if acquired other than by his own...

  19. 27 CFR 555.123 - Records maintained by licensed manufacturers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... marks of identification. (3) Quantity (applicable quantity units, such as pounds of explosives, number...), blasting agents (ba), detonators (det), display fireworks (df), etc.) and size (length and diameter or... or brand name of manufacturer or name of importer, as applicable, if acquired other than by his own...

  20. 75 FR 27934 - Qualified Nonpersonal Use Vehicles

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-19

    ... that the vehicle is a police, fire, or public safety officer vehicle. A marking on a license plate is.... Rescue activity means search or rescue assistance in locating or extracting from danger persons lost... law to carry firearms, execute search warrants, and to make arrests (other than merely a citizen's...

  1. 22 CFR 125.6 - Certification requirements for exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... LICENSES FOR THE EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.6 Certification requirements for exemptions. (a) To claim an exemption for the export of technical data under the provisions of.... Certifications consist of clearly marking the package or letter containing the technical data “22 CFR [insert...

  2. 77 FR 54935 - Government-Owned Inventions, Available for Licensing.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    ...: Systems and Methods for Peak-Seeking Control Polarization-Induced Fading in Fiber-Optic System; NASA Case... FURTHER INFORMATION CONTACT: Mark W. Homer, Patent Counsel, NASA Management Office--JPL, 4800 Oak Grove...; NASA Case No. NPO-47580-1: Energy Harvesting Systems and Methods of Assembling Same; NASA Case No. NPO...

  3. 22 CFR 125.6 - Certification requirements for exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    .... Certifications consist of clearly marking the package or letter containing the technical data “22 CFR [insert... LICENSES FOR THE EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.6 Certification requirements for exemptions. (a) To claim an exemption for the export of technical data under the provisions of...

  4. 22 CFR 125.6 - Certification requirements for exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    .... Certifications consist of clearly marking the package or letter containing the technical data “22 CFR [insert... LICENSES FOR THE EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.6 Certification requirements for exemptions. (a) To claim an exemption for the export of technical data under the provisions of...

  5. 22 CFR 125.6 - Certification requirements for exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    .... Certifications consist of clearly marking the package or letter containing the technical data “22 CFR [insert... LICENSES FOR THE EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.6 Certification requirements for exemptions. (a) To claim an exemption for the export of technical data under the provisions of...

  6. 22 CFR 125.6 - Certification requirements for exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    .... Certifications consist of clearly marking the package or letter containing the technical data “22 CFR [insert... LICENSES FOR THE EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.6 Certification requirements for exemptions. (a) To claim an exemption for the export of technical data under the provisions of...

  7. Digital Data Matrix Scanner Developnent At Marshall Space Flight Center

    NASA Technical Reports Server (NTRS)

    2004-01-01

    Research at NASA's Marshall Space Flight Center has resulted in a system for reading hidden identification codes using a hand-held magnetic scanner. It's an invention that could help businesses improve inventory management, enhance safety, improve security, and aid in recall efforts if defects are discovered. Two-dimensional Data Matrix symbols consisting of letters and numbers permanently etched on items for identification and resembling a small checkerboard pattern are more efficient and reliable than traditional bar codes, and can store up to 100 times more information. A team led by Fred Schramm of the Marshall Center's Technology Transfer Department, in partnership with PRI,Torrance, California, has developed a hand-held device that can read this special type of coded symbols, even if covered by up to six layers of paint. Before this new technology was available, matrix symbols were read with optical scanners, and only if the codes were visible. This latest improvement in digital Data Matrix technologies offers greater flexibility for businesses and industries already using the marking system. Paint, inks, and pastes containing magnetic properties are applied in matrix symbol patterns to objects with two-dimensional codes, and the codes are read by a magnetic scanner, even after being covered with paint or other coatings. The ability to read hidden matrix symbols promises a wide range of benefits in a number of fields, including airlines, electronics, healthcare, and the automotive industry. Many industries would like to hide information on a part, so it can be read only by the party who put it there. For instance, the automotive industry uses direct parts marking for inventory control, but for aesthetic purposes the marks often need to be invisible. Symbols have been applied to a variety of materials, including metal, plastic, glass, paper, fabric and foam, on everything from electronic parts to pharmaceuticals to livestock. The portability of the hand-held scanner makes work faster and easier. It reads marks in darkness, under bright light that might interfere with optical reading of visible marks, and can detect symbols obscured by discoloration or contamination. Through a license with NASA, another partner, Robotic Vision Systems, Inc., of Nashua, New Hampshire, will sell the scanner on the commercial market. NASA continues to seek additional companies to license the product. Joint efforts by Marshall researchers and industry partners are aimed at improving dentification technology as part of NASA's program to better life on Earth through technology designed for the space program. In this photo, Don Roxby, Robotic Vision Systems, Inc., (left)demonstrates the magnetic handheld scanner for Fred Schramm, (Right) MSFC Technology Transfer Department.

  8. License suspensions for nondriving offenses : practices in four states that may ease the financial impact on low-income individuals, February 2010.

    DOT National Transportation Integrated Search

    2010-02-01

    States suspend drivers licenses for a variety of offenses that are not directly related to driving safety.1 For example, all states have procedures to suspend licenses for child support arrearages. In addition, a majority of states issue suspensio...

  9. 77 FR 40917 - Application and Amendment to Facility Operating Licenses Involving Proposed No Significant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    .... FOR FURTHER INFORMATION CONTACT: Mark C. Roberts, Senior Health Physicist, Decommissioning Branch... as may be imposed in exercise of that discretion upon the making of limited appearance statements... by the release of the information.) If NRC staff makes the finding of need for SUNSI and likelihood...

  10. Can Any Childbirth Educator Use the Lamaze Trademark?

    PubMed Central

    Philipsen, Nayna Campbell

    2001-01-01

    A Lamaze Certified Childbirth Educator asks about the use of the name Lamaze, which is a licensed (trademark) name. A trademark is a mark of authenticity. It protects both the users and the consumers. Penalty for unauthorized use (e.g., by a childbirth educator who is not an LCCE) can be substantial. PMID:17273241

  11. AP1000{sup R} licensing and deployment in the United States

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jordan, R. P.; Russ, P. A.; Filiak, P. P.

    2012-07-01

    In recent years, both domestic and foreign utilities have turned to the standardized Westinghouse AP1000 plant design in satisfying their near - and long-term - sustainable energy needs. As direct support to these actions, licensing the AP1000 design has played a significant role by providing one of the fundamental bases in clearing regulatory hurdles leading to the start of new plant construction. Within the U.S. alone, Westinghouse AP1000 licensing activities have reached unprecedented milestones with the approvals of both AP1000 Design Certification and Southern Company's combined construction permit and operating license (COL) application directly supporting the construction of two newmore » nuclear plants in Georgia. Further COL application approvals are immediately pending for an additional two AP1000 plants in South Carolina. And, across the U.S. nuclear industry spectrum, there are 10 other COL applications under regulatory review representing some 16 new plants at 10 sites. In total, these actions represent the first wave of new plant licensing under the regulatory approval process since 1978. Fundamental to the Nuclear Regulatory Commission's AP1000 Design Certification is the formal recognition of the AP1000 passive safety design through regulatory acceptance rulemaking. Through recognition and deployment of the AP1000 Design Certification, the utility licensee / operator of this reactor design are now offered an opportunity to use a simplified 'one-step' combined license process, thereby managing substantial back-end construction schedule risk from regulatory and intervention delays. Application of this regulatory philosophy represents both acceptance and encouragement of standardized reactor designs like the AP1000. With the recent AP1000 Design Certification and utility COL acceptances, the fundamental licensing processes of this philosophy have successfully proven the attainment of significant milestones with the next stage licensing actions directed towards deployment. AP1000 Design Certification and COL deployment, and management of the plant construction in accordance with the conditions within these approvals, remain as significant site and corporate responsibilities. These licensing-construction integrated activities must now focus on identifying and resolving 'as-built' departures from the standardized design as assessed against the certified AP1000 technical and licensing basis. Within this paper, significant aspects of the AP1000 U.S. licensing will be discussed, including identifying systems and processes used in ensuring compliance while deploying the standardized design. Critical licensing steps, licensing deployment actions as plant construction progresses and defining the road forward to a successful completion of licensing actions will be addressed. (authors)« less

  12. Evidence that the capacity of nongenotoxic carcinogens to induce oxidative stress is subject to marked variability.

    PubMed

    Henderson, Colin J; Cameron, Amy R; Chatham, Lynsey; Stanley, Lesley A; Wolf, Charles Roland

    2015-05-01

    Many drugs and environmental chemicals which are not directly mutagenic have the capacity to increase the incidence of tumors in the liver and other tissues. For this reason, such compounds are known as nongenotoxic carcinogens. The mechanisms underlying their effects remain unclear; however, their capacity to induce oxidative stress is considered to be a critical step in the carcinogenic process, although the evidence that this is actually the case remains equivocal and sparse. We have exploited a novel heme oxygenase-1 reporter mouse to evaluate the capacity of nongenotoxic carcinogens with different mechanisms of action to induce oxidative stress in the liver in vivo. When these compounds were administered at doses reported to cause liver tumors, marked differences in activation of the reporter were observed. 1,4-Dichlorobenzene and nafenopin were strong inducers of oxidative stress, whereas phenobarbital, piperonyl butoxide, cyproterone acetate, and WY14,643 were, at best, only very weak inducers. In the case of phenobarbital and thioacetamide, the number of LacZ-positive hepatocytes increased with time, and for the latter also with dose. The data obtained demonstrate that although some nongenotoxic carcinogens can induce oxidative stress, it is not a dominant feature of the response to these compounds. Therefore in contrast to the current models, these data suggest that oxidative stress is not a key determinant in the mechanism of nongenotoxic carcinogenesis but may contribute to the effects in a compound-specific manner. © The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

  13. Tackling alcohol related violence in city centres: effect of emergency medicine and police intervention

    PubMed Central

    Warburton, A L; Shepherd, J P

    2006-01-01

    Objectives To identify correlates of alcohol related assault injury in the city centre of a European capital city, with particular reference to emergency department (ED) and police interventions, and number and capacity of licensed premises. Methods Assaults resulting in ED treatment were studied using a longitudinal controlled intervention, a three stage design during a three year period of rapid expansion in the night‐time economy, when ED initiated targeted police interventions were delivered. A controlled ED intervention targeted at high risk night‐clubs was carried out. Main outcome measure was ED treatment after assault in licensed premises and the street. Results Targeted police intervention was associated with substantial reductions in assaults in licensed premises but unexpected increases in street assault were also observed (34% overall: 105% in the principal entertainment thoroughfare). Combined police/ED intervention was associated with a significantly greater reduction compared with police intervention alone (OR = 0.61, 95% CI 0.40 to 0.91). Street assault correlated significantly with numbers and capacity of premises. Risk of assault was 50% greater in and around licensed premises in the city centre compared with those in the suburbs, although dispersion of violence to more licensed premises was not observed. Conclusions Marked decreases in licensed premises assaults resulting from targeted policing were enhanced by the intervention of ED and maxillofacial consultants. Capacity of licensed premises was a major predictor of assaults in the city centre street in which they are clustered. City centre assault injury prevention can be achieved through police/ED interventions targeted at high risk licensed premises, which should also target the streets around which these premises are clustered. PMID:16373796

  14. The iRoCS Toolbox--3D analysis of the plant root apical meristem at cellular resolution.

    PubMed

    Schmidt, Thorsten; Pasternak, Taras; Liu, Kun; Blein, Thomas; Aubry-Hivet, Dorothée; Dovzhenko, Alexander; Duerr, Jasmin; Teale, William; Ditengou, Franck A; Burkhardt, Hans; Ronneberger, Olaf; Palme, Klaus

    2014-03-01

    To achieve a detailed understanding of processes in biological systems, cellular features must be quantified in the three-dimensional (3D) context of cells and organs. We described use of the intrinsic root coordinate system (iRoCS) as a reference model for the root apical meristem of plants. iRoCS enables direct and quantitative comparison between the root tips of plant populations at single-cell resolution. The iRoCS Toolbox automatically fits standardized coordinates to raw 3D image data. It detects nuclei or segments cells, automatically fits the coordinate system, and groups the nuclei/cells into the root's tissue layers. The division status of each nucleus may also be determined. The only manual step required is to mark the quiescent centre. All intermediate outputs may be refined if necessary. The ability to learn the visual appearance of nuclei by example allows the iRoCS Toolbox to be easily adapted to various phenotypes. The iRoCS Toolbox is provided as an open-source software package, licensed under the GNU General Public License, to make it accessible to a broad community. To demonstrate the power of the technique, we measured subtle changes in cell division patterns caused by modified auxin flux within the Arabidopsis thaliana root apical meristem. © 2014 The Authors The Plant Journal © 2014 John Wiley & Sons Ltd.

  15. Parts quality management: Direct part marking of data matrix symbol for mission assurance

    NASA Astrophysics Data System (ADS)

    Moss, Chantrice; Chakrabarti, Suman; Scott, David W.

    A United States Government Accountability Office (GAO) review of twelve NASA programs found widespread parts quality problems contributing to significant cost overruns, schedule delays, and reduced system reliability. Direct part marking with Data Matrix symbols could significantly improve the quality of inventory control and parts lifecycle management. This paper examines the feasibility of using direct part marking technologies for use in future NASA programs. A structural analysis is based on marked material type, operational environment (e.g., ground, suborbital, Low Earth Orbit), durability of marks, ease of operation, reliability, and affordability. A cost-benefits analysis considers marking technology (label printing, data plates, and direct part marking) and marking types (two-dimensional machine-readable, human-readable). Previous NASA parts marking efforts and historical cost data are accounted for, including in-house vs. outsourced marking. Some marking methods are still under development. While this paper focuses on NASA programs, results may be applicable to a variety of industrial environments.

  16. Parts Quality Management: Direct Part Marking of Data Matrix Symbol for Mission Assurance

    NASA Technical Reports Server (NTRS)

    Moss, Chantrice; Chakrabarti, Suman; Scott, David W.

    2013-01-01

    A United States Government Accountability Office (GAO) review of twelve NASA programs found widespread parts quality problems contributing to significant cost overruns, schedule delays, and reduced system reliability. Direct part marking with Data Matrix symbols could significantly improve the quality of inventory control and parts lifecycle management. This paper examines the feasibility of using direct part marking technologies for use in future NASA programs. A structural analysis is based on marked material type, operational environment (e.g., ground, suborbital, Low Earth Orbit), durability of marks, ease of operation, reliability, and affordability. A cost-benefits analysis considers marking technology (label printing, data plates, and direct part marking) and marking types (two-dimensional machine-readable, human-readable). Previous NASA parts marking efforts and historical cost data are accounted for, including inhouse vs. outsourced marking. Some marking methods are still under development. While this paper focuses on NASA programs, results may be applicable to a variety of industrial environments.

  17. 75 FR 13187 - Self-Regulatory Organizations; NASDAQ OMX PHLX, Inc.; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-18

    ...), NASDAQ-100(R) and NASDAQ-100 Index(R) are registered trademarks of The NASDAQ OMX Group, Inc. (which with... proposes to: (i) Increase the options transaction charge for Registered Options Traders (``ROTs'') and... 2000[supreg] is a trademark and service mark of the Frank Russell Company, used under license. Neither...

  18. Slow off the Mark: Elementary School Teachers and the Crisis in STEM Education

    ERIC Educational Resources Information Center

    Epstein, Diana; Miller, Raegen T.

    2011-01-01

    Prospective teachers can typically obtain a license to teach elementary school without taking a rigorous college-level STEM class such as calculus, statistics, or chemistry, and without demonstrating a solid grasp of mathematics knowledge, scientific knowledge, or the nature of scientific inquiry. This is not a recipe for ensuring students have…

  19. 78 FR 59923 - Cave Run Energy, LLC; Notice of Intent To File License Application, Filing of Pre-Application...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-30

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 14376-001] Cave Run Energy...: July 21, 2013. d. Submitted By: Cave Run Energy, LLC. e. Name of Project: Cave Run Hydroelectric...: 18 CFR 5.3 of the Commission's regulations. h. Potential Applicant Contact: Mark Boumansour, Cave Run...

  20. A Standard Handshake for the Use of Electronic Materials

    ERIC Educational Resources Information Center

    Glenn, David

    2007-01-01

    For most people on campuses, September means revising syllabi, enjoying football, or avoiding the person you broke up with last spring. For college librarians, it marks the beginning of "renewal season." It is time for the tedious work of placing orders and negotiating licenses for next year's journals. However, relief may be on the horizon.…

  1. 48 CFR 52.247-26 - Government Direction and Marking.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Government Direction and....247-26 Government Direction and Marking. As prescribed in 47.207-8(a)(3), insert the following clause... relocations are involved: Government Direction and Marking (APR 1984) The agency being relocated shall tag or...

  2. 48 CFR 52.247-26 - Government Direction and Marking.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Government Direction and....247-26 Government Direction and Marking. As prescribed in 47.207-8(a)(3), insert the following clause... relocations are involved: Government Direction and Marking (APR 1984) The agency being relocated shall tag or...

  3. Additive Manufacturing: An Analysis of Intellectual Property Rights on Navy Acquisition

    DTIC Science & Technology

    2015-12-01

    Administration Office of Investment and Innovation . (2014, February 24). Small Business Innovative Research (SBIR) Program directive . Washington, DC... license agreements outside of standard licensing . • Small Business Innovative Research (SBIR) Rights: These rights prevent government users from...DFARS 227.227.7104(a) License Rights Principal Objective To identify the scope of data rights to be delivered under the Small Business Innovative

  4. Parts Quality Management: Direct Part Marking via Data Matrix Symbols for Mission Assurance

    NASA Technical Reports Server (NTRS)

    Moss, Chantrice

    2013-01-01

    A United States Government Accountability Office (GAO) review of twelve NASA programs found widespread parts quality problems contributing to significant cost overruns, schedule delays, and reduced system reliability. Direct part-marking with Data Matrix symbols could significantly improve the quality of inventory control and parts lifecycle management. This paper examines the feasibility of using 15 marking technologies for use in future NASA programs. A structural analysis is based on marked material type, operational environment (e.g., ground, suborbital, orbital), durability of marks, ease of operation, reliability, and affordability. A cost-benefits analysis considers marking technology (data plates, label printing, direct part marking) and marking types (two-dimensional machine-readable, human-readable). Previous NASA parts marking efforts and historical cost data are accounted for, including in-house vs. outsourced marking. Some marking methods are still under development. While this paper focuses on NASA programs, results may be applicable to a variety of industrial environments.

  5. The discovery of the prokaryotic cytoskeleton: 25th anniversary.

    PubMed

    Erickson, Harold P

    2017-02-01

    The year 2017 marks the 25th anniversary of the discovery of homologues of tubulin and actin in prokaryotes. Before 1992, it was largely accepted that tubulin and actin were unique to eukaryotes. Then three laboratories independently discovered that FtsZ, a protein already known as a key player in bacterial cytokinesis, had the "tubulin signature sequence" present in all α-, β-, and γ-tubulins. That same year, three candidates for bacterial actins were discovered in silico. X-ray crystal structures have since confirmed multiple bacterial proteins to be homologues of eukaryotic tubulin and actin. Tubulin and actin were apparently derived from bacterial precursors that had already evolved a wide range of cytoskeletal functions. © 2017 Erickson. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  6. Special Report on "Allegations of Conflict of Interest Regarding Licensing of PROTECT by Argonne National Laboratory"

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    2009-08-01

    In February 2009, the Office of Inspector General received a letter from Congressman Mark Steven Kirk of Illinois, which included constituent allegations that an exclusive technology licensing agreement by Argonne National Laboratory was tainted by inadequate competition, conflicts of interest, and other improprieties. The technology in question was for the Program for Response Options and Technology Enhancements for Chemical/Biological Terrorism, commonly referred to as PROTECT. Because of the importance of the Department of Energy's technology transfer program, especially as implementation of the American Recovery and Reinvestment Act matures, we reviewed selected aspects of the licensing process for PROTECT to determinemore » whether the allegations had merit. In summary, under the facts developed during our review, it was understandable that interested parties concluded that there was a conflict of interest in this matter and that Argonne may have provided the successful licensee with an unfair advantage. In part, this was consistent with aspects of the complaint from Congressman Kirk's constituent.« less

  7. Use and user patterns among Michigan licensed off-highway vehicles ownership types

    Treesearch

    Joel A. Lynch; Charles M. Nelson

    2002-01-01

    Conventional off-highway vehicles (OHVs) range from small personal vehicles, such as motorcycles and all terrain vehicles to full-size passenger vehicles such as four-wheel drive trucks. The market and general recreational use of OHVs has changed markedly over the past thirty years. While many studies of OHV enthusiasts generalize to all OHV types, little research has...

  8. 10 CFR 55.4 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... means testing conducted to verify a simulation facility's performance as compared to actual or predicted... which a simulation facility's control room configuration, system control arrangement, and design data... of a facility and to direct the licensed activities of licensed operators. Simulation facility means...

  9. 10 CFR 55.4 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... means testing conducted to verify a simulation facility's performance as compared to actual or predicted... which a simulation facility's control room configuration, system control arrangement, and design data... of a facility and to direct the licensed activities of licensed operators. Simulation facility means...

  10. 10 CFR 55.4 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... means testing conducted to verify a simulation facility's performance as compared to actual or predicted... which a simulation facility's control room configuration, system control arrangement, and design data... of a facility and to direct the licensed activities of licensed operators. Simulation facility means...

  11. 78 FR 3906 - Prospective Grant of a Co-Exclusive License: Adenovirus-Based Controls and Calibrators for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-17

    ... contemplated license should be directed to: Uri Reichman, Ph.D., M.B.A, Office of Technology Transfer, National... calibrators and controls for molecular diagnostics (e.g. real time PCR tests). The prospective co-exclusive...

  12. 75 FR 29545 - Ocean Transportation Intermediary License Applicants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-26

    .... Atlantic Cargo Logistics LLC (OFF & NVO), 120 South Woodland Blvd., 216, Deland, FL 32720. Officers: Dietmar Lutte, Manager, (Qualifying Individual) Susan Lutte, Member, Application Type: New OFF & NVO License. Direct Delivery Logistics and Supply, LLC (OFF & NVO) 2006 Wilson Road, Humble, TX 77396...

  13. 77 FR 64971 - Lock+ Hydro Friends Fund XLII, LLC; Notice of Waiver, in Part, of Prefiling Consultation Required...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ... Friends Fund XLII, LLC; Notice of Waiver, in Part, of Prefiling Consultation Required Under Section 4.38(C... License. b. Project No.: 13739-002. c. Date Filed: September 17, 2012. d. Applicant: Lock+ Hydro Friends.... 791(a)-825(r). h. Applicant Contact: Mr. Mark R. Stover, Lock+\\TM\\ Hydro Friends Fund XLII, c/o Hydro...

  14. 76 FR 44866 - Credit Union Service Organizations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ... by a licensed certified public accountant. These requirements will ensure NCUA will be able to... public accountant, and submit a financial report directly to NCUA. According to NCUA records, of the 2... licensed certified public accountant in accordance with generally accepted auditing standards. A wholly...

  15. 10 CFR 150.20 - Recognition of Agreement State licenses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 150.20 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXEMPTIONS AND CONTINUED REGULATORY AUTHORITY IN AGREEMENT STATES AND IN OFFSHORE WATERS UNDER SECTION 274 Reciprocity § 150.20 Recognition of... office for directing the licensed activity and retaining radiation safety records, is granted a general...

  16. 10 CFR 150.20 - Recognition of Agreement State licenses.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 150.20 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXEMPTIONS AND CONTINUED REGULATORY AUTHORITY IN AGREEMENT STATES AND IN OFFSHORE WATERS UNDER SECTION 274 Reciprocity § 150.20 Recognition of... office for directing the licensed activity and retaining radiation safety records, is granted a general...

  17. 75 FR 5035 - Notice of Intent To Grant Exclusive License

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ... DEPARTMENT OF AGRICULTURE Agricultural Research Service Notice of Intent To Grant Exclusive License AGENCY: Agricultural Research Service, USDA. ACTION: Notice of intent. SUMMARY: Notice is hereby..., ``Direct Polymerase Chain Reaction Assay, or Bio-PCR'', issued on June 25, 2002. DATES: Comments must be...

  18. Hydropower resources at risk: The status of hydropower regulation and development - 1997

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hunt, R.T.; Hunt, J.A.

    This report documents today`s hydropower licensing and development status based on published data as follows: (a) Federal Energy Regulatory Commission (FERC) databases, maintained by FERC`s Office of Hydropower Licensing, of: (1) operating FERC-regulated projects, federal projects, and known unlicensed projects; (2) surrendered licenses; and, (3) recent licensing and relicensing actions; (b) Energy Information Administration (EIA) data on installed capacity and generation from 1949 through 1995 for the various resources used to produce electricity in the U.S.; and, (c) FERC licensing orders, and environmental assessments or environmental impact statements for each individual project relicensed since 1980. The analysis conducted to preparemore » this paper includes the effects of all FERC hydropower licensing actions since 1980, and applies those findings to estimate the costs of hydropower licensing and development activity for the next 15 years. It also quantifies the national cost of hydropower regulation. The future estimates are quite conservative. The are presented in 1996 dollars without speculating on the effects of future inflation, license surrenders, conditions imposed through open-ended license articles, license terms greater than 30 years, or low water years. Instead, they show the most directly predictable influences on licensing outcomes using actual experiences since ECPA (after 1986).« less

  19. The effect of the European traditional use directive on the register of herbal medicinal products in Spain.

    PubMed

    Tejedor-García, Noelia; García-Pastor, Coral; Navalmoral-Arenas, Estefanía; Blas-Espada, Javier; Madrigal-Martínez, Antonio; de Lucio-Cazaña, Francisco Javier

    2015-01-01

    Directive 2004/24/EC, which came into force in 2011, created new regulatory requirements for traditional herbal medicines (THM). This study compared the Spanish THM registry before and after the Directive came fully into force in 2011. We consulted the herbal medicinal plant and drug catalogues (General Council of the Official Colleges of Pharmacists), the website of the European Medicines Agency (EMA), and retail web sites. Of 315 THM (from 39 companies) licensed in Spain in 2010, only 48 (10 companies) remained licensed in 2013, mainly due to their withdrawal: the EMA had received just 123 applications from Spain and at least 34% formerly licensed THM had shifted to the less strictly regulated food sector, while up to 54% might have disappeared from the market. However, there is still a significant presence of retail websites making illegal health claims. In Spain, the public health benefits of the Directive 2004/24/EC might be less than expected. Copyright © 2014 SESPAS. Published by Elsevier Espana. All rights reserved.

  20. 47 CFR 25.136 - Licensing provisions for user transceivers in the 1.6/2.4 GHz, 1.5/1.6 GHz, and 2 GHz Mobile...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Applications and Licenses Earth Stations § 25.136 Licensing provisions for user transceivers in the 1.6/2.4 GHz... specified in § 25.213, earth stations operating in the 1.6/2.4 GHz and 1.5/1.6 GHz Mobile Satellite Services... aircraft unless the earth station has a direct physical connection to the aircraft cabin or cockpit...

  1. 47 CFR 25.136 - Licensing provisions for user transceivers in the 1.6/2.4 GHz, 1.5/1.6 GHz, and 2 GHz Mobile...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Applications and Licenses Earth Stations § 25.136 Licensing provisions for user transceivers in the 1.6/2.4 GHz... specified in § 25.213, earth stations operating in the 1.6/2.4 GHz and 1.5/1.6 GHz Mobile Satellite Services... aircraft unless the earth station has a direct physical connection to the aircraft cabin or cockpit...

  2. 47 CFR 25.136 - Licensing provisions for user transceivers in the 1.6/2.4 GHz, 1.5/1.6 GHz, and 2 GHz Mobile...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Applications and Licenses Earth Stations § 25.136 Licensing provisions for user transceivers in the 1.6/2.4 GHz... specified in § 25.213, earth stations operating in the 1.6/2.4 GHz and 1.5/1.6 GHz Mobile-Satellite Services... aircraft unless the earth station has a direct physical connection to the aircraft cabin or cockpit...

  3. The Acquisition of Differential Object Marking in L2 Spanish Learners

    ERIC Educational Resources Information Center

    Martoccio, Alyssa Marie

    2012-01-01

    This dissertation tests a grammatical structure, differential object marking (DOM), which is particularly difficult for L2 learners to acquire. DOM is a phenomenon in which some direct objects are morphologically marked to distinguish them from subjects (Comrie, 1979). In Spanish, animate and specific direct objects are marked with the preposition…

  4. 31 CFR 515.575 - Humanitarian projects.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Humanitarian projects. 515.575 Section..., Authorizations, and Statements of Licensing Policy § 515.575 Humanitarian projects. Specific licenses may be... such additional transactions as are directly incident to certain humanitarian projects in or related to...

  5. Lighting and marking policies are associated with reduced farm equipment-related crash rates: a policy analysis of nine Midwestern US states.

    PubMed

    Ramirez, Marizen; Bedford, Ronald; Wu, Hongqian; Harland, Karisa; Cavanaugh, Joseph E; Peek-Asa, Corinne

    2016-09-01

    To evaluate the effectiveness of roadway policies for lighting and marking of farm equipment in reducing crashes in Illinois, Iowa, Kansas, Minnesota, Missouri, Nebraska, North Dakota, South Dakota and Wisconsin. In this ecological study, state policies on lighting and marking of farm equipment were scored for compliance with standards of the American Society of Agricultural and Biological Engineers (ASABE). Using generalized estimating equations negative binomial models, we estimated the relationships between lighting and marking scores, and farm equipment crash rates, per 100 000 farm operations. A total of 7083 crashes involving farm equipment was reported from 2005 to 2010 in the Upper Midwest and Great Plains. As the state lighting and marking score increased by 5 units, crash rates reduced by 17% (rate ratio=0.83; 95% CI 0.78 to 0.88). Lighting-only (rate ratio=0.48; 95% CI 0.45 to 0.51) and marking-only policies (rate ratio=0.89; 95% CI 0.83 to 0.96) were each associated with reduced crash rates. Aligning lighting and marking policies with ASABE standards may effectively reduce crash rates involving farm equipment. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  6. 7 CFR 110.5 - Availability of records to facilitate medical treatment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... agencies that deal with pesticide use or any health issue related to the use of pesticides when necessary... attending licensed health care professional, or an individual acting under the direction of the attending licensed health care professional, determines that any record of the application of any restricted use...

  7. 31 CFR 515.566 - Religious activities in Cuba.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Religious activities in Cuba. 515.566..., Authorizations, and Statements of Licensing Policy § 515.566 Religious activities in Cuba. (a) General license... transactions as are directly incident to religious activities in Cuba under the auspices of the organization...

  8. 31 CFR 515.566 - Religious activities in Cuba.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Religious activities in Cuba. 515.566..., Authorizations, and Statements of Licensing Policy § 515.566 Religious activities in Cuba. (a) General license... transactions as are directly incident to religious activities in Cuba under the auspices of the organization...

  9. 31 CFR 515.566 - Religious activities in Cuba.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Religious activities in Cuba. 515.566..., Authorizations, and Statements of Licensing Policy § 515.566 Religious activities in Cuba. (a) General license... transactions as are directly incident to religious activities in Cuba under the auspices of the organization...

  10. 31 CFR 515.566 - Religious activities in Cuba.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Religious activities in Cuba. 515.566..., Authorizations, and Statements of Licensing Policy § 515.566 Religious activities in Cuba. (a) General license... transactions as are directly incident to religious activities in Cuba under the auspices of the organization...

  11. 78 FR 25310 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    .../diminished. There are no design changes associated with this TS amendment. The DC power system/batteries will... changes restructure the Technical Specifications (TS) for the direct current (DC) electrical power system... battery and battery charger operability requirements. The DC electrical power system, including associated...

  12. 10 CFR 55.13 - General exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false General exemptions. 55.13 Section 55.13 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Exemptions § 55.13 General exemptions. The regulations in this part do not require a license for an individual who— (a) Under the direction and in the...

  13. 47 CFR 25.148 - Licensing provisions for the Direct Broadcast Satellite Service.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Applications and Licenses Space Stations § 25.148... contracting for construction of the satellite station(s) within one year of the grant of the authorization. The satellite stations shall also be required to be in operation within six years of the authorization...

  14. 47 CFR 25.148 - Licensing provisions for the Direct Broadcast Satellite Service.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Applications and Licenses Space Stations § 25.148... contracting for construction of the satellite station(s) within one year of the grant of the authorization. The satellite stations shall also be required to be in operation within six years of the authorization...

  15. 47 CFR 25.148 - Licensing provisions for the Direct Broadcast Satellite Service.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Applications and Licenses Space Stations § 25.148... contracting for construction of the satellite station(s) within one year of the grant of the authorization. The satellite stations shall also be required to be in operation within six years of the authorization...

  16. 47 CFR 25.148 - Licensing provisions for the Direct Broadcast Satellite Service.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Applications and Licenses Space Stations § 25.148... contracting for construction of the satellite station(s) within one year of the grant of the authorization. The satellite stations shall also be required to be in operation within six years of the authorization...

  17. 10 CFR 55.13 - General exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false General exemptions. 55.13 Section 55.13 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Exemptions § 55.13 General exemptions. The regulations in this part do not require a license for an individual who— (a) Under the direction and in the...

  18. The role of the University Licensing Office in transferring intellectual property to industry

    NASA Technical Reports Server (NTRS)

    Preston, John T.

    1992-01-01

    Universities in the US have a significant impact on business through the transfer of technology. This transfer of technology takes various forms, including faculty communications, faculty consulting activities, and the direct transfer of technology through the licensing of patents, copyrights, and other intellectual property to industry. The topics discussed include the following: background of the MIT Technology Licensing Office (TLO), goals of the MIT TLO, MIT's technology transfer philosophy, and important factors for success in new company formation.

  19. Impact of Gene Patents and Licensing Practices on Access to Genetic Testing for Alzheimer’s Disease

    PubMed Central

    Skeehan, Katie; Heaney, Christopher; Cook-Deegan, Robert

    2010-01-01

    Genetic testing for Alzheimer’s disease (AD) includes genotyping for apolipoprotein E, for late-onset AD, and three rare autosomal dominant, early-onset forms of AD associated with different genes (APP, PSEN1 and PSEN2). According to researchers, patents have not impeded research in the field, nor were patents an important consideration in the quest for the genetic risk factors. Athena Diagnostics holds exclusive licenses from Duke University for three “method” patents covering APOE genetic testing. Athena offers tests for APOE and genes associated with early onset, autosomal dominant AD. One of those presenilin genes is patented and exclusively licensed to Athena; the other presenilin gene was patented but the patent was allowed to lapse; and one (APP) is patented only as a research tool and patent claims do not cover diagnostic use. Direct-to-consumer testing is available for some AD-related genes, apparently without a license. Athena Diagnostics consolidated its position in the market for AD genetic testing by collecting exclusive rights to patents arising from university research. Duke University also used its licenses to Athena to enforce adherence to clinical guidelines, including elimination of the service from Smart Genetics, which was offering direct-to-consumer risk assessment based on APOE genotyping. PMID:20393312

  20. COMPARISON OF THE MORPHOLOGICAL TRANSFORMING ACTIVITIES OF FJORD-REGION PAHS WITH DIBENZO[A,E}PYRENE & BENZO{A}PYRENE

    EPA Science Inventory

    Po(l'cyclic Aromatic Compound" 1999, Vol. 16. pp. 141-149 ICJ 1999OPA (Overseas Publishers Associationl NV. Reprints available directly from the publisher Published by license under Photocopying permitted by license only the Gordon and Breach Science Publishers imprint.
    Print...

  1. 42 CFR 418.106 - Condition of participation: Drugs and biologicals, medical supplies, and durable medical equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... direction of a qualified licensed pharmacist who is an employee of or under contract with the hospice. The provided pharmacist services must include evaluation of a patient's response to medication therapy... licensed nurse, nurse practitioner (where appropriate), pharmacist, or physician; and (ii) The individual...

  2. 42 CFR 418.106 - Condition of participation: Drugs and biologicals, medical supplies, and durable medical equipment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... direction of a qualified licensed pharmacist who is an employee of or under contract with the hospice. The provided pharmacist services must include evaluation of a patient's response to medication therapy... licensed nurse, nurse practitioner (where appropriate), pharmacist, or physician; and (ii) The individual...

  3. 42 CFR 418.106 - Condition of participation: Drugs and biologicals, medical supplies, and durable medical equipment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... direction of a qualified licensed pharmacist who is an employee of or under contract with the hospice. The provided pharmacist services must include evaluation of a patient's response to medication therapy... licensed nurse, nurse practitioner (where appropriate), pharmacist, or physician; and (ii) The individual...

  4. 42 CFR 418.106 - Condition of participation: Drugs and biologicals, medical supplies, and durable medical equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... direction of a qualified licensed pharmacist who is an employee of or under contract with the hospice. The provided pharmacist services must include evaluation of a patient's response to medication therapy... licensed nurse, nurse practitioner (where appropriate), pharmacist, or physician; and (ii) The individual...

  5. 42 CFR 418.106 - Condition of participation: Drugs and biologicals, medical supplies, and durable medical equipment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... direction of a qualified licensed pharmacist who is an employee of or under contract with the hospice. The provided pharmacist services must include evaluation of a patient's response to medication therapy... licensed nurse, nurse practitioner (where appropriate), pharmacist, or physician; and (ii) The individual...

  6. 76 FR 25697 - Government-Owned Inventions; Availability for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ...; Availability for Licensing AGENCY: National Institutes of Health, Public Health Service, HHS. ACTION: Notice... commercially available one, which means it now matches the PCR product generated in the qPCR reaction in the... and directly matches the PCR product generated in the qPCR reaction. The standard plasmid is easy to...

  7. 47 CFR 73.155 - Periodic directional antenna performance recertification.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 4 2014-10-01 2014-10-01 false Periodic directional antenna performance... RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.155 Periodic directional antenna performance recertification. A station licensed with a directional antenna pattern pursuant to a proof of...

  8. 47 CFR 73.155 - Periodic directional antenna performance recertification.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 4 2013-10-01 2013-10-01 false Periodic directional antenna performance... RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.155 Periodic directional antenna performance recertification. A station licensed with a directional antenna pattern pursuant to a proof of...

  9. 47 CFR 73.155 - Periodic directional antenna performance recertification.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Periodic directional antenna performance... RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.155 Periodic directional antenna performance recertification. A station licensed with a directional antenna pattern pursuant to a proof of...

  10. 47 CFR 73.155 - Periodic directional antenna performance recertification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Periodic directional antenna performance... RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.155 Periodic directional antenna performance recertification. A station licensed with a directional antenna pattern pursuant to a proof of...

  11. 47 CFR 73.155 - Periodic directional antenna performance recertification.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 4 2012-10-01 2012-10-01 false Periodic directional antenna performance... RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.155 Periodic directional antenna performance recertification. A station licensed with a directional antenna pattern pursuant to a proof of...

  12. 76 FR 50111 - Airworthiness Directives; Fokker Services B.V. Model F.28 Mark 1000, 2000, 3000, and 4000 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-12

    ... Directives; Fokker Services B.V. Model F.28 Mark 1000, 2000, 3000, and 4000 Airplanes AGENCY: Federal... Services B.V. Model F.28 Mark 1000, 2000, 3000, and 4000 airplanes, certificated in any category, all...

  13. Nucleosomes influence multiple steps during replication initiation

    PubMed Central

    Azmi, Ishara F; Watanabe, Shinya; Maloney, Michael F; Kang, Sukhyun; Belsky, Jason A; MacAlpine, David M; Peterson, Craig L; Bell, Stephen P

    2017-01-01

    Eukaryotic replication origin licensing, activation and timing are influenced by chromatin but a mechanistic understanding is lacking. Using reconstituted nucleosomal DNA replication assays, we assessed the impact of nucleosomes on replication initiation. To generate distinct nucleosomal landscapes, different chromatin-remodeling enzymes (CREs) were used to remodel nucleosomes on origin-DNA templates. Nucleosomal organization influenced two steps of replication initiation: origin licensing and helicase activation. Origin licensing assays showed that local nucleosome positioning enhanced origin specificity and modulated helicase loading by influencing ORC DNA binding. Interestingly, SWI/SNF- and RSC-remodeled nucleosomes were permissive for origin licensing but showed reduced helicase activation. Specific CREs rescued replication of these templates if added prior to helicase activation, indicating a permissive chromatin state must be established during origin licensing to allow efficient origin activation. Our studies show nucleosomes directly modulate origin licensing and activation through distinct mechanisms and provide insights into the regulation of replication initiation by chromatin. DOI: http://dx.doi.org/10.7554/eLife.22512.001 PMID:28322723

  14. Self-recognition in pigeons revisited.

    PubMed

    Uchino, Emiko; Watanabe, Shigeru

    2014-11-01

    Recognition of a self-image in a mirror is investigated using the mark test during which a mark is placed onto a point on the body that is not directly visible, and the presence or absence of self-directed behaviors is evaluated for the mirror-observing subjects. Great apes, dolphins, possibly elephants, and magpies have all passed the mark test, that is, displayed self-directed behaviors, whereas monkeys, crows, and other animals have failed the test even though they were able to use a mirror to find a not-directly-visible object. Self-directed behavior and mirror use are prerequisites of a successful mark test, and the absence of these behaviors may lead to false negative results. Epstein, Lanza, and Skinner (1981) reported self-directed behavior of pigeons in front of a mirror after explicit training of self-directed pecking and of pecking an object with the aid of a mirror, but certain other researchers could not confirm the results. The aim of the present study was to conduct the mark test with two pigeons that had received extensive training of the prerequisite behaviors. Crucial points of the training were identical topography (pecking) and the same reinforcement (food) in the prerequisite behaviors as well as sufficient training of these behaviors. After training for the prerequisite behaviors, both pigeons spontaneously integrated the learned self-directed and mirror-use behavior and displayed self-directed behavior in a mark test. This indicates that pigeons display mirror self-recognition after training of suitable ontogenetic contingency. © Society for the Experimental Analysis of Behavior.

  15. 10 CFR Appendix A to Part 110 - Illustrative List of Nuclear Reactor Equipment Under NRC Export Licensing Authority

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Illustrative List of Nuclear Reactor Equipment Under NRC... List of Nuclear Reactor Equipment Under NRC Export Licensing Authority Note—A nuclear reactor basically includes the items within or attached directly to the reactor vessel, the equipment which controls the...

  16. 10 CFR Appendix A to Part 110 - Illustrative List of Nuclear Reactor Equipment Under NRC Export Licensing Authority

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Illustrative List of Nuclear Reactor Equipment Under NRC... List of Nuclear Reactor Equipment Under NRC Export Licensing Authority Note—A nuclear reactor basically includes the items within or attached directly to the reactor vessel, the equipment which controls the...

  17. 78 FR 69429 - Prospective Grant of Exclusive License: The Development of Modified T-cells for the Treatment of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... Exclusive License: The Development of Modified T-cells for the Treatment of Multiple Myeloma AGENCY... Targeting B-cell Maturation Antigen'' [HHS Ref. E-040-2012/0-US-01]. The patent rights in these inventions..., development, and manufacture of chimeric antigen receptor (CAR)-expressing human T-cells directed against B...

  18. 15 CFR 752.7 - Direct shipment to customers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Direct shipment to customers. 752.7... COMPREHENSIVE LICENSE § 752.7 Direct shipment to customers. (a) General authorization. (1) Upon request by a... directly to the requesting consignee's customer in either: (i) The requesting consignee's country; or (ii...

  19. Increase in cellular triacylglycerol content and emergence of large ER-associated lipid droplets in the absence of CDP-DG synthase function.

    PubMed

    He, Yue; Yam, Candice; Pomraning, Kyle; Chin, Jacqueline S R; Yew, Joanne Y; Freitag, Michael; Oliferenko, Snezhana

    2014-12-15

    Excess fatty acids and sterols are stored as triacylglycerols and sterol esters in specialized cellular organelles, called lipid droplets. Understanding what determines the cellular amount of neutral lipids and their packaging into lipid droplets is of fundamental and applied interest. Using two species of fission yeast, we show that cycling cells deficient in the function of the ER-resident CDP-DG synthase Cds1 exhibit markedly increased triacylglycerol content and assemble large lipid droplets closely associated with the ER membranes. We demonstrate that these unusual structures recruit the triacylglycerol synthesis machinery and grow by expansion rather than by fusion. Our results suggest that interfering with the CDP-DG route of phosphatidic acid utilization rewires cellular metabolism to adopt a triacylglycerol-rich lifestyle reliant on the Kennedy pathway. © 2014 He, Yam, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  20. Mental Health Care: Licensing and Certification Requirements for Staff in State Hospitals. Fact Sheet for the Honorable Daniel K. Inouye, United States Senate.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC. Div. of Human Resources.

    The Office of United States Senator Daniel Inouye requested information on state minimum licensing and certification requirements for physicians, psychiatrists, psychologists, social workers, and nurses who work directly with patients in state mental hospitals. To obtain this information, the General Accounting Office called the offices of the…

  1. Podiatrists Licensed in Washington.

    ERIC Educational Resources Information Center

    Washington State Dept. of Social and Health Services, Olympia. Health Manpower Project.

    This survey, based on a 95 0/0 response rate, determined that of all the podiatrists licensed in the state of Washington, 69 0/0 live within the state, 95 0/0 were actively employed in that profession, and almost all were in private practice. The primary work function of 83 0/0 was direct patient care, and over half of the respondents worked 40 to…

  2. 75 FR 14094 - Order to Deny Petitions for Reconsideration of MVDDS Technical and Licensing Rules in the 12 GHz...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-24

    ... Petitions for Reconsideration of MVDDS Technical and Licensing Rules in the 12 GHz Band AGENCY: Federal... Commission announces that the Office of Management and Budget (OMB) has approved, for a period of three years... Authorize Subsidiary Terrestrial Use of the 12.2- 12.7 GHz Band by Direct Broadcast Satellite Licensees and...

  3. 48 CFR Appendix J to Chapter 7 - Direct USAID Contracts With a Cooperating Country National and With a Third Country National for...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... authorized travel status. (o) Dependents shall mean spouse and children (including step and adopted children... shall be examined by a licensed doctor of medicine, and shall obtain a statement of medical opinion that... physical examination for himself/herself and any authorized dependents by a licensed doctor of medicine...

  4. 78 FR 36014 - Deepwater Port License Application: Liberty Natural Gas, LLC, Port Ambrose Deepwater Port

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-14

    ... (NEPA) of 1969 (42 U.S.C. 4321 et seq.). The U.S. Environmental Protection Agency (EPA) and the U.S... Coastal State'' any coastal state which (A) would be directly connected by pipeline to a deepwater port as... the Designation of Adjacent Coastal States for Deepwater Port License Applications in the Federal...

  5. Making tradeoffs between the reasons to leave and reasons to stay employed in long-term care homes: perspectives of licensed nursing staff.

    PubMed

    McGilton, Katherine S; Boscart, Veronique M; Brown, Maryanne; Bowers, Barbara

    2014-06-01

    Turnover of licensed nursing staff in long-term care (LTC) settings (e.g., nursing homes) is a mounting concern and is associated with poor quality of care and low staff morale. Retention and turnover research in LTC have focused primarily on direct care workers (i.e., nurse aides) leaving the issues largely unexplored for licensed nursing staff (i.e., registered nurses and licensed practical nurses). The main objective of this study was to understand factors that influence nurses' intentions to remain employed at their current job. Qualitative descriptive study. Seven nursing homes in Ontario, Canada. A convenience sample of forty-one licensed LTC nurses. Data were collected through focus groups conducted at each of the participating nursing homes. Focus group discussions were transcribed verbatim. Directed content analysis was used to identify and develop themes. Work conditions were a salient element affecting nurses' intention to stay and included impact of regulations on nurse role flexibility and professional judgment, an underfunded system contributing to insufficient resources and staffing, and a lack of supportive leadership. Factors promoting nurses' willingness to stay included the development of meaningful relationships with residents and staff and opportunities for learning and professional development. Nurses also considered personal and life circumstances (e.g., marital status and seniority) when discussing intention to stay. Nurses in this study weighed positive and negative work-related factors as well as personal circumstances to determine their intent to stay. Developing a more individualized approach to address attrition of licensed nurses in LTC may be the most successful strategy for improving retention of highly skilled staff in this sector. Copyright © 2013 Elsevier Ltd. All rights reserved.

  6. 21 CFR 801.45 - Devices that must be directly marked with a unique device identifier.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Devices that must be directly marked with a unique device identifier. 801.45 Section 801.45 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... previously marked under paragraph (a) of this section. (e) Exception to be noted in design history file. A...

  7. Why Did the Storm Ex-Gaston (2010) Fail to Redevelop During the PREDICT Experiment

    DTIC Science & Technology

    2016-07-13

    License. Why did the storm ex-Gaston (2010) fail to redevelop during the PREDICT experiment ? Thomas M. Freismuth1, Blake Rutherford2, Mark A. Boothe1, and...2013), recent case studies in the field in the western North Pacific during the Tropical Cyclone Structure Experiment 2008 (TCS08, Montgomery et al...of ex-Gaston (2010) during the PREDICT experiment is arguably one of the most exten- sively observed non-developing tropical disturbances ever. The 5

  8. Instruments for Reading Direct-Marked Data-Matrix Symbols

    NASA Technical Reports Server (NTRS)

    Schramm, Harry F.; Corder, Eric L.

    2006-01-01

    Improved optoelectronic instruments (specially configured digital cameras) for reading direct-marked data-matrix symbols on the surfaces of optically reflective objects (including specularly reflective ones) are undergoing development. Data-matrix symbols are two-dimensional binary patterns that are used, like common bar codes, for automated identification of objects. The first data-matrix symbols were checkerboard-like patterns of black-and-white rectangles, typically existing in the forms of paint, ink, or detachable labels. The major advantage of direct marking (the marks are more durable than are painted or printed symbols or detachable labels) is offset by a major disadvantage (the marks generated by some marking methods do not provide sufficient contrast to be readable by optoelectronic instruments designed to read black-and-white data-matrix symbols). Heretofore, elaborate lighting, lensing, and software schemes have been tried in efforts to solve the contrast problem in direct-mark matrix- symbol readers. In comparison with prior readers based on those schemes, the readers now undergoing development are expected to be more effective while costing less. All of the prior direct-mark matrix-symbol readers are designed to be aimed perpendicularly to marked target surfaces, and they tolerate very little angular offset. However, the reader now undergoing development not only tolerates angular offset but depends on angular offset as a means of obtaining the needed contrast, as described below. The prototype reader (see Figure 1) includes an electronic camera in the form of a charge-coupled-device (CCD) image detector equipped with a telecentric lens. It also includes a source of collimated visible light and a source of collimated infrared light for illuminating a target. The visible and infrared illumination complement each other: the visible illumination is more useful for aiming the reader toward a target, while the infrared illumination is more useful for reading symbols on highly reflective surfaces. By use of beam splitters, the visible and infrared collimated lights are introduced along the optical path of the telecentric lens, so that the target is illuminated and viewed from the same direction.

  9. Sandia National Laboratories: Research: Laboratory Directed Research &

    Science.gov Websites

    ; Technology Defense Systems & Assessments About Defense Systems & Assessments Program Areas Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  10. Economic Value of Army Foreign Military Sales

    DTIC Science & Technology

    2015-12-01

    12 2. Direct Commercial Sales vs. Foreign Military Sales .....................15 3...the final bill to the customer, and the DSCA sends a closure certificate to DFAS. 2. Direct Commercial Sales vs. Foreign Military Sales Direct ...is defined as the “coproduction, licensed production, countertrade, subcontracting, and technology transfer—mandated by foreign governments as a

  11. Epilepsy-related automobile accidents in Japan: legal changes about a precedent and penal regulations.

    PubMed

    Imataka, G; Arisue, K

    2016-01-01

    In Japan, having epilepsy was defined as an absolute disqualification for driving license in the Road Traffic Act enacted in 1960. In view of subsequent changes in domestic road traffic conditions and advances in epilepsy treatment and owing to efforts by interested parties, the 2002 revision of the Road Traffic Act conditionally permitted epileptic patients to obtain a driver's license. However, as fatal traffic accidents associated with driving by epileptic patients continued thereafter, their legal responsibility for driving a car was extensively discussed in newspapers and other media as well as in the Diet. In June 2013, the Road Traffic Act was again revised to incorporate punitive clauses applicable to those with difficulty in driving (not limited to epilepsy only but including various diseases and conditions) who falsely claimed that they had no driving difficulty in the procedure for obtaining or renewing their driver's license. With this revision marking a turning point, the Act on Punishment for Acts That Cause Death or Injury to Others by Driving a Car was enforced as a new statute in May 2014. This paper presents five cases of traffic accidents involved with epileptic patients to explain the impact of these accidents on the 2013 legal revision and a subsequent trend of toughening of legal penalties.

  12. 76 FR 58330 - Javits Report 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... DEPARTMENT OF STATE [Public Notice: 7596] Javits Report 2012 SUMMARY: In accordance with Sec. 25... Arms Sale Proposal (the Javits Report) covering all sales and licensed commercial exports of major...., direct commercial sales) for the report. DATES: All Javits Report 2012 submissions regarding direct...

  13. 75 FR 51326 - Javits Report 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-19

    ... DEPARTMENT OF STATE [Public Notice 7124] Javits Report 2011 SUMMARY: In accordance with Sec. 25 of... Sale Proposal (the Javits Report) covering all sales and licensed commercial exports of major weapons...., direct commercial sales) for the report. DATES: All Javits Report 2011 submissions regarding direct...

  14. The professional nurse and regulation.

    PubMed

    Flook, Denise M

    2003-06-01

    The regulation of nursing began as a simple registry process to protect the nursing title and the public. Today, the primary purpose is still the protection of the public through defining nursing practice, approving nursing education, and overseeing the competence of nurses through licensing and disciplinary rules and regulations. State Boards of Nursing are legislatively given the authority to license and discipline the nursing profession. The RN is responsible for the care given to assigned patients. Issues of staffing, delegation, and reporting of incompetent or impaired nurses are a concern of nurses today with regard to their license. Each nurse must understand the regulations, which vary from state to state, that directly and indirectly affect his/her daily practice. As the health care environment is met with several challenges, pressures are increasing to modernize the licensing and competency assessment of nurses. Ultimately, the safety of patients must remain at the center of the regulatory debate.

  15. Identifying e-cigarette vape stores: description of an online search methodology.

    PubMed

    Kim, Annice E; Loomis, Brett; Rhodes, Bryan; Eggers, Matthew E; Liedtke, Christopher; Porter, Lauren

    2016-04-01

    Although the overall impact of Electronic Nicotine Delivery Systems (ENDS) on public health is unclear, awareness, use, and marketing of the products have increased markedly in recent years. Identifying the increasing number of 'vape stores' that specialise in selling ENDS can be challenging given the lack of regulatory policies and licensing. This study assesses the utility of online search methods in identifying ENDS vape stores. We conducted online searches in Google Maps, Yelp, and YellowPages to identify listings of ENDS vape stores in Florida, and used a crowdsourcing platform to call and verify stores that primarily sold ENDS to consumers. We compared store listings generated from the online search and crowdsourcing methodology to list licensed tobacco and ENDS retailers from the Florida Department of Business and Professional Regulation. The combined results from all three online sources yielded a total of 403 ENDS vape stores. Nearly 32.5% of these stores were on the state tobacco licensure list, while 67.5% were not. Accuracy of online results was highest for Yelp (77.6%), followed by YellowPages (77.1%) and Google (53.0%). Using the online search methodology we identified more ENDS vape stores than were on the state tobacco licensure list. This approach may be a promising strategy to identify and track the growth of ENDS vape stores over time, especially in states without a systematic licensing requirement for such stores. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  16. A Short Term Evaluation of the Direct Operating Grants. Final Report.

    ERIC Educational Resources Information Center

    Levy-Coughlin Partnership.

    Findings of a survey of a sample of center-based child care (CBCC) programs and private home day care (PHDC) agencies listed in Ontario's Direct Operating Grant Calculation Data Base are reported. During 1988, licensed child care programs in Ontario received approximately 46.5 million dollars in Direct Operating Grants (DOGs). Grants were…

  17. Economic Value of Army Foreign Military Sales

    DTIC Science & Technology

    2015-12-01

    12 2. Direct Commercial Sales vs. Foreign Military Sales ............... 15 3. GAO and CBO Reports... Directive DOS Department of State DSCA Defense Security Cooperation Agency EOQ Economic Order Quantity FAA Foreign Assistance Act FAR Federal...and approves export license requests for Direct Commercial Sales (DCS) of defense articles (DSCA, 2012, p. C1.3.1). The DSCA summarizes the FMS

  18. Report on Institutional Eligibility.

    ERIC Educational Resources Information Center

    George Washington Univ., Washington, DC. Inst. for Educational Leadership.

    The federal government has traditionally relied on a variety of private accrediting bodies and state chartering and licensing authorities for determining eligibility and exercising direct supervision and consumer protection in education. As Federal financial assistance directly to students has expanded (3 million students received $6.4 million in…

  19. A Probe for Measuring Spacecraft Surface Potentials Using a Direct-Gate Field Effect Transistor.

    DTIC Science & Technology

    1983-09-30

    SURFACE POTENTIALS USING A DIRECT-GATE FIELD EFFECT TRANSISTOR Mark N. Horenstein Anton Havretic Trustees of Boston University 881 Commonwealth Avenue...1933 Transistor 6. PERFORMING ORG. REPORT NUMBER 7. AUTHOR(s) S. CONTRACT OR GRANT NUMBER(&) ’_5 Mark N. Horenstein Anton Mavretic F19628-82-K-00 34...at AFGL. These tests can be considered the bench mark tests for device performance, with all elements of the monitoring system optimized to eliminate

  20. An optical watermarking solution for color personal identification pictures

    NASA Astrophysics Data System (ADS)

    Tan, Yi-zhou; Liu, Hai-bo; Huang, Shui-hua; Sheng, Ben-jian; Pan, Zhong-ming

    2009-11-01

    This paper presents a new approach for embedding authentication information into image on printed materials based on optical projection technique. Our experimental setup consists of two parts, one is a common camera, and the other is a LCD projector, which project a pattern on personnel's body (especially on the face). The pattern, generated by a computer, act as the illumination light source with sinusoidal distribution and it is also the watermark signal. For a color image, the watermark is embedded into the blue channel. While we take pictures (256×256 and 512×512, 567×390 pixels, respectively), an invisible mark is embedded directly into magnitude coefficients of Discrete Fourier transform (DFT) at exposure moment. Both optical and digital correlation is suitable for detection of this type of watermark. The decoded watermark is a set of concentric circles or sectors in the DFT domain (middle frequencies region) which is robust to photographing, printing and scanning. The unlawful people modify or replace the original photograph, and make fake passport (drivers' license and so on). Experiments show, it is difficult to forge certificates in which a watermark was embedded by our projector-camera combination based on analogue watermark method rather than classical digital method.

  1. Dishing Direct Instruction: Teachers and Parents Tell All!

    ERIC Educational Resources Information Center

    Kanfush, Philip M.

    2014-01-01

    This qualitative study assessed overall parent and teacher satisfaction with Direct Instruction reading for students having low incidence disabilities at an approved, private-licensed school for exceptional children in the Commonwealth of Pennsylvania. Results of four parent and four teacher interviews coupled with document analysis disclosed…

  2. The Nature of Object Marking in American Sign Language

    ERIC Educational Resources Information Center

    Gokgoz, Kadir

    2013-01-01

    In this dissertation, I examine the nature of object marking in American Sign Language (ASL). I investigate object marking by means of directionality (the movement of the verb towards a certain location in signing space) and by means of handling classifiers (certain handshapes accompanying the verb). I propose that object marking in ASL is…

  3. Collaboration and Compromise: The Big Picture of Energy Systems Integration

    Science.gov Websites

    research direction at NREL. Photo by Dennis Schroeder Portrait of ESI researcher Mark O'Malley Mark by Dennis Schroeder Mark O'Malley is a research fellow at the National Renewable Energy Laboratory

  4. Front lighted optical tooling method and apparatus

    DOEpatents

    Stone, W.J.

    1983-06-30

    An optical tooling method and apparatus uses a front lighted shadowgraphic technique to enhance visual contrast of reflected light. The apparatus includes an optical assembly including a fiducial mark, such as cross hairs, reflecting polarized light with a first polarization, a polarizing element backing the fiducial mark and a reflective surface backing the polarizing element for reflecting polarized light bypassing the fiducial mark and traveling through the polarizing element. The light reflected by the reflecting surface is directed through a second pass of the polarizing element toward the frontal direction with a polarization differing from the polarization of the light reflected by the fiducial mark. When used as a tooling target, the optical assembly may be mounted directly to a reference surface or may be secured in a mounting, such as a magnetic mounting. The optical assembly may also be mounted in a plane defining structure and used as a spherometer in conjunction with an optical depth measuring instrument.

  5. 77 FR 9273 - USEC Inc. (American Centrifuge Lead Cascade Facility and American Centrifuge Plant); Direct...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-16

    ... NUCLEAR REGULATORY COMMISSION [NRC-2010-0355] USEC Inc. (American Centrifuge Lead Cascade Facility and American Centrifuge Plant); Direct Transfer of Licenses In the Matter of USEC INC. (American Centrifuge Lead Cascade Facility and American Centrifuge Plant); Order EA-12- [[Page 9274

  6. Glossary

    MedlinePlus

    ... Loss Resources Resources Resources Content Licensing and Co-branding Glossary Advance directive - A general term that describes ... approach to expert medical care, pain management, and emotional and spiritual support expressly tailored to the person's ...

  7. Inspection of the Department`s export licensing process for dual-use and munitions commodities

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1993-08-10

    The purpose of our inspection was to review the Department of Energy`s (Energy) export licensing process for dual-use and military (munitions) commodities subject to nuclear nonproliferation controls. Specifically, we reviewed Energy`s authorities, procedures, and policies pertaining to the export licensing process and examined procedures for safeguarding data transmitted between Energy and other agencies involved in the export licensing process. We also reviewed Energy`s role as a member of the Subgroup on Nuclear Export Coordination. Our review of the sample of 60 export cases did not find evidence to lead us to believe that Energy`s recommendations for these cases were inappropriatemore » or incorrect. We identified, however, problems regarding management systems associated with the export license review process. We found that without documentation supporting export licensing decisions by the Export Control Operations Division (ECOD), we could not determine whether ECOD analysts considered all required criteria in their review of export cases referred to Energy. For example, we found that the ECOD did not retain records documenting the bases for its advice, recommendations, or decisions regarding its reviews of export license cases or revisions to lists of controlled commodities and, therefore, was not in compliance with certain provisions of the Export Administration Act, as amended, and Energy records management directives. Additionally, we found that the degree of compliance by Energy with the export licensing review criteria contained in the Export Administration Regulations and the Nuclear Non-Proliferation Act of 1978 could not be determined because ECOD did not retain records documenting the bases for its advice and recommendations on export cases.« less

  8. 77 FR 14569 - Notice of Intent To Grant Exclusive License

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-12

    ... Direct Chip Attach Packaging Methodologies and Apparatuses for Harsh Environments, LEW 17,256-1, to... equipment; semiconductor manufacturing; material manufacturing such as metallurgy, refractory processes, and...

  9. [The principle of registration, evaluation and testing of disinfecting preparations].

    PubMed

    Röhm-Rodowald, Ewa; Jakimiak, Bozenna; Podgórska, Marta

    2008-01-01

    Disinfectants are used to produce a state in which the number of living micro-organisms has been reduced to a level which is appropriate to the practical situation. For any products which are included in the Biocidal Directive 98/8/EC, for which specific activity is claimed, test data has to be approved by the regulatory authority and a product license obtained before the product can be offered for sale. Disinfectants can be recorded as biocidal products or medical devices. Presently, it is possible to measure the activity of a product on defined micro-organisms in specified experimental conditions. Efficacy is the result of the use of a product according to a defined application. To allow different requirements in different areas of application, separate tests and pass criteria have been or will be prepared for each of following three areas of application: medical, veterinary and group comprising food, industrial, domestic and institutional areas. The laboratory methods to be used for testing the activity of chemical disinfectants meets the European standards. The tests are categorised on a modular basis as follows: phase 1 tests, phase 2 step 1 tests, phase 2 step 2 tests and phase 3 tests. In order to claim that a product has disinfectant properties, suitable for use in the medical area, the product shall be tested according to European standards: phase 2 step 1 tests, phase 2 step 2 tests. Phase 1 tests are not required to support claims for chemical disinfectants used in human medicine. Only phase 1 tests are required to support claims for active substances for which no particular area of application is specified. Medical devices are subjects to the European Directive 93/42/EEC which requires that a product must carry a CE mark. Disinfectants which are intended specifically by its manufacturer to be used on medical devices are themselves medical devices and so these products, as well as conforming to the instrument disinfection European standards as specified in EN 14885, are also required to carry a CE mark.

  10. Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.

    PubMed

    Kazlauskaite, Agne; Martínez-Torres, R Julio; Wilkie, Scott; Kumar, Atul; Peltier, Julien; Gonzalez, Alba; Johnson, Clare; Zhang, Jinwei; Hope, Anthony G; Peggie, Mark; Trost, Matthias; van Aalten, Daan M F; Alessi, Dario R; Prescott, Alan R; Knebel, Axel; Walden, Helen; Muqit, Miratul M K

    2015-08-01

    Mutations in the mitochondrial protein kinase PINK1 are associated with autosomal recessive Parkinson disease (PD). We and other groups have reported that PINK1 activates Parkin E3 ligase activity both directly via phosphorylation of Parkin serine 65 (Ser(65))--which lies within its ubiquitin-like domain (Ubl)--and indirectly through phosphorylation of ubiquitin at Ser(65). How Ser(65)-phosphorylated ubiquitin (ubiquitin(Phospho-Ser65)) contributes to Parkin activation is currently unknown. Here, we demonstrate that ubiquitin(Phospho-Ser65) binding to Parkin dramatically increases the rate and stoichiometry of Parkin phosphorylation at Ser(65) by PINK1 in vitro. Analysis of the Parkin structure, corroborated by site-directed mutagenesis, shows that the conserved His302 and Lys151 residues play a critical role in binding of ubiquitin(Phospho-Ser65), thereby promoting Parkin Ser(65) phosphorylation and activation of its E3 ligase activity in vitro. Mutation of His302 markedly inhibits Parkin Ser(65) phosphorylation at the mitochondria, which is associated with a marked reduction in its E3 ligase activity following mitochondrial depolarisation. We show that the binding of ubiquitin(Phospho-Ser65) to Parkin disrupts the interaction between the Ubl domain and C-terminal region, thereby increasing the accessibility of Parkin Ser(65). Finally, purified Parkin maximally phosphorylated at Ser(65) in vitro cannot be further activated by the addition of ubiquitin(Phospho-Ser65). Our results thus suggest that a major role of ubiquitin(Phospho-Ser65) is to promote PINK1-mediated phosphorylation of Parkin at Ser(65), leading to maximal activation of Parkin E3 ligase activity. His302 and Lys151 are likely to line a phospho-Ser(65)-binding pocket on the surface of Parkin that is critical for the ubiquitin(Phospho-Ser65) interaction. This study provides new mechanistic insights into Parkin activation by ubiquitin(Phospho-Ser65), which could aid in the development of Parkin activators that mimic the effect of ubiquitin(Phospho-Ser65). © 2015 The Authors. Published under the terms of the CC BY 4.0 license.

  11. 7 CFR 868.80 - Who may be licensed.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...; and (3) Has no interest, financial or otherwise, direct or indirect in merchandising, handling... indirect in merchandising, handling, storing, or processing the kind of commodities or related products to...

  12. Security management techniques and evaluative checklists for security force effectiveness. Technical report (final) Sep 80-Jul 81

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schurman, D.L.; Datesman, G.H. Jr; Truitt, J.O.

    The report presents a system for evaluating and correcting deficiencies in security-force effectiveness in licensed nuclear facilities. There are four checklists which security managers can copy directly, or can use as guidelines for developing their own checklists. The checklists are keyed to corrective-action guides found in the body of the report. In addition to the corrective-action guides, the report gives background information on the nature of security systems and discussions of various special problems of the licensed nuclear industry.

  13. Eating on Demand

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Under subcontract to McDonnell-Douglas Corporation, Enersyst Development Center developed air impingement technology through oven designs for NASA's Space Station Freedom. Jets of hot air at the top and bottom of the oven are focused on the food, rather than heating the oven cavity as in a traditional thermal oven. By heating the food directly, foods cook faster and more consistently, retaining flavor and texture. Several companies have licensed this technology, including KRh Thermal Systems, which has introduced a line of Hot Choice vending machines. Enersyst has also licensed the first home application to Thermador.

  14. Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome.

    PubMed

    Bicknell, Louise S; Walker, Sarah; Klingseisen, Anna; Stiff, Tom; Leitch, Andrea; Kerzendorfer, Claudia; Martin, Carol-Anne; Yeyati, Patricia; Al Sanna, Nouriya; Bober, Michael; Johnson, Diana; Wise, Carol; Jackson, Andrew P; O'Driscoll, Mark; Jeggo, Penny A

    2011-02-27

    Studies into disorders of extreme growth failure (for example, Seckel syndrome and Majewski osteodysplastic primordial dwarfism type II) have implicated fundamental cellular processes of DNA damage response signaling and centrosome function in the regulation of human growth. Here we report that mutations in ORC1, encoding a subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. We establish that these mutations disrupt known ORC1 functions including pre-replicative complex formation and origin activation. ORC1 deficiency perturbs S-phase entry and S-phase progression. Additionally, we show that Orc1 depletion in zebrafish is sufficient to markedly reduce body size during rapid embryonic growth. Our data suggest a model in which ORC1 mutations impair replication licensing, slowing cell cycle progression and consequently impeding growth during development, particularly at times of rapid proliferation. These findings establish a novel mechanism for the pathogenesis of microcephalic dwarfism and show a surprising but important developmental impact of impaired origin licensing.

  15. Graph-based word sense disambiguation of biomedical documents.

    PubMed

    Agirre, Eneko; Soroa, Aitor; Stevenson, Mark

    2010-11-15

    Word Sense Disambiguation (WSD), automatically identifying the meaning of ambiguous words in context, is an important stage of text processing. This article presents a graph-based approach to WSD in the biomedical domain. The method is unsupervised and does not require any labeled training data. It makes use of knowledge from the Unified Medical Language System (UMLS) Metathesaurus which is represented as a graph. A state-of-the-art algorithm, Personalized PageRank, is used to perform WSD. When evaluated on the NLM-WSD dataset, the algorithm outperforms other methods that rely on the UMLS Metathesaurus alone. The WSD system is open source licensed and available from http://ixa2.si.ehu.es/ukb/. The UMLS, MetaMap program and NLM-WSD corpus are available from the National Library of Medicine https://www.nlm.nih.gov/research/umls/, http://mmtx.nlm.nih.gov and http://wsd.nlm.nih.gov. Software to convert the NLM-WSD corpus into a format that can be used by our WSD system is available from http://www.dcs.shef.ac.uk/∼marks/biomedical_wsd under open source license.

  16. Variation in assessment and standard setting practices across UK undergraduate medicine and the need for a benchmark.

    PubMed

    MacDougall, Margaret

    2015-10-31

    The principal aim of this study is to provide an account of variation in UK undergraduate medical assessment styles and corresponding standard setting approaches with a view to highlighting the importance of a UK national licensing exam in recognizing a common standard. Using a secure online survey system, response data were collected during the period 13 - 30 January 2014 from selected specialists in medical education assessment, who served as representatives for their respective medical schools. Assessment styles and corresponding choices of standard setting methods vary markedly across UK medical schools. While there is considerable consensus on the application of compensatory approaches, individual schools display their own nuances through use of hybrid assessment and standard setting styles, uptake of less popular standard setting techniques and divided views on norm referencing. The extent of variation in assessment and standard setting practices across UK medical schools validates the concern that there is a lack of evidence that UK medical students achieve a common standard on graduation. A national licensing exam is therefore a viable option for benchmarking the performance of all UK undergraduate medical students.

  17. Trivalent chromatin marks the way in.

    PubMed

    Hysolli, Eriona; Park, In-Hyun

    2013-11-07

    Recently in Cell, Wapinski et al. (2013) investigated the epigenetic mechanisms underlying the direct conversion of fibroblasts to induced neurons (iNs). They found that Ascl1 acts as a pioneer factor at neurogenic loci marked by a closed "trivalent" chromatin state in cells permissive to direct conversion, but not in restrictive cell types. Copyright © 2013 Elsevier Inc. All rights reserved.

  18. Laser direct marking applied to rasterizing miniature Data Matrix Code on aluminum alloy

    NASA Astrophysics Data System (ADS)

    Li, Xia-Shuang; He, Wei-Ping; Lei, Lei; Wang, Jian; Guo, Gai-Fang; Zhang, Teng-Yun; Yue, Ting

    2016-03-01

    Precise miniaturization of 2D Data Matrix (DM) Codes on Aluminum alloy formed by raster mode laser direct part marking is demonstrated. The characteristic edge over-burn effects, which render vector mode laser direct part marking inadequate for producing precise and readable miniature codes, are minimized with raster mode laser marking. To obtain the control mechanism for the contrast and print growth of miniature DM code by raster laser marking process, the temperature field model of long pulse laser interaction with material is established. From the experimental results, laser average power and Q frequency have an important effect on the contrast and print growth of miniature DM code, and the threshold of laser average power and Q frequency for an identifiable miniature DM code are respectively 3.6 W and 110 kHz, which matches the model well within normal operating conditions. In addition, the empirical model of correlation occurring between laser marking parameters and module size is also obtained, and the optimal processing parameter values for an identifiable miniature DM code of different but certain data size are given. It is also found that an increase of the repeat scanning number effectively improves the surface finish of bore, the appearance consistency of modules, which has benefit to reading. The reading quality of miniature DM code is greatly improved using ultrasonic cleaning in water by avoiding the interference of color speckles surrounding modules.

  19. 77 FR 52030 - Information Collections Being Reviewed by the Federal Communications Commission Under Delegated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-28

    ... directional antenna to file a request for program test authority 10 days prior to date on which it desires to...) requires a licensee of an FM station replacing a directional antenna without changes to file a modification of the license application within 10 days after commencing operations with the replacement antenna...

  20. Standardizing the Pre-Licensure Supervision Process: A Commentary on Advocating for Direct Observation of Skills

    ERIC Educational Resources Information Center

    Gray, Neal D.; Erickson, Paul

    2013-01-01

    The present paper advocates for standardized regulations and laws for supervision of pre-licensed counselors in the United States, particularly for direct observation of clinical skills. A review of regulations by the American Counseling Association (ACA) Office of Professional Affairs (2012) reveals that only two states (Arizona and North…

  1. 76 FR 37682 - Airworthiness Directives; Teledyne Continental Motors (TCM) and Rolls-Royce Motors Ltd. (R-RM...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-28

    ... Continental Motors (TCM) and Rolls-Royce Motors Ltd. (R-RM) Series Reciprocating Engines AGENCY: Federal... supersede an existing airworthiness directive (AD) that applies to certain TCM and R-RM series reciprocating... range of magneto S/ Ns affected, and of the need to include certain engines made by R-RM, under license...

  2. 47 CFR 1.1104 - Schedule of charges for applications and other filings for media services.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MJT 302-DTV & 159 e. License Renewal (per application) (Electronic Filing) 303-S & 159 170.00 MGT f... (per application) (Electronic Filing) 302-AM & 159 615.00 MMR e. AM Directional Antenna (per... (Electronic Filing) 302-FM & 159 195.00 MHR e. FM Directional Antenna (Electronic Filing) 302-FM & 159 590.00...

  3. 47 CFR 25.146 - Licensing and operating authorization provisions for the non-geostationary satellite orbit fixed...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... following: (1) Single-entry validation equivalent power flux-density, in the space-to-Earth direction, (EPFD down) limits. (i) Provide a set of power flux-density (pfd) masks, on the surface of the Earth, for... section. (2) Single-entry validation equivalent power flux-density, in the Earth-to-space direction, EPFD...

  4. 47 CFR 25.146 - Licensing and operating authorization provisions for the non-geostationary satellite orbit fixed...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... following: (1) Single-entry validation equivalent power flux-density, in the space-to-Earth direction, (EPFD down) limits. (i) Provide a set of power flux-density (pfd) masks, on the surface of the Earth, for... section. (2) Single-entry validation equivalent power flux-density, in the Earth-to-space direction, EPFD...

  5. 47 CFR 25.146 - Licensing and operating authorization provisions for the non-geostationary satellite orbit fixed...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... following: (1) Single-entry validation equivalent power flux-density, in the space-to-Earth direction, (EPFD down) limits. (i) Provide a set of power flux-density (pfd) masks, on the surface of the Earth, for... section. (2) Single-entry validation equivalent power flux-density, in the Earth-to-space direction, EPFD...

  6. Spontaneous and electric field-controlled front-rear polarization of human keratinocytes.

    PubMed

    Saltukoglu, Deniz; Grünewald, Julian; Strohmeyer, Nico; Bensch, Robert; Ulbrich, Maximilian H; Ronneberger, Olaf; Simons, Matias

    2015-12-01

    It has long been known that electrical fields (EFs) are able to influence the direction of migrating cells, a process commonly referred to as electrotaxis or galvanotaxis. Most studies have focused on migrating cells equipped with an existing polarity before EF application, making it difficult to delineate EF-specific pathways. Here we study the initial events in front-rear organization of spreading keratinocytes to dissect the molecular requirements for random and EF-controlled polarization. We find that Arp2/3-dependent protrusive forces and Rac1/Cdc42 activity were generally required for both forms of polarization but were dispensable for controlling the direction of EF-controlled polarization. By contrast, we found a crucial role for extracellular pH as well as G protein coupled-receptor (GPCR) or purinergic signaling in the control of directionality. The normal direction of polarization toward the cathode was reverted by lowering extracellular pH. Polarization toward the anode was also seen at neutral pH when GPCR or purinergic signaling was inhibited. However, the stepwise increase of extracellular pH in this scenario led to restoration of cathodal polarization. Overall our work puts forward a model in which the EF uses distinct polarization pathways. The cathodal pathway involves GPCR/purinergic signaling and is dominant over the anodal pathway at neutral pH. © 2015 Saltukoglu et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  7. Small-molecule agonists of mammalian Diaphanous-related (mDia) formins reveal an effective glioblastoma anti-invasion strategy.

    PubMed

    Arden, Jessica D; Lavik, Kari I; Rubinic, Kaitlin A; Chiaia, Nicolas; Khuder, Sadik A; Howard, Marthe J; Nestor-Kalinoski, Andrea L; Alberts, Arthur S; Eisenmann, Kathryn M

    2015-11-01

    The extensive invasive capacity of glioblastoma (GBM) makes it resistant to surgery, radiotherapy, and chemotherapy and thus makes it lethal. In vivo, GBM invasion is mediated by Rho GTPases through unidentified downstream effectors. Mammalian Diaphanous (mDia) family formins are Rho-directed effectors that regulate the F-actin cytoskeleton to support tumor cell motility. Historically, anti-invasion strategies focused upon mDia inhibition, whereas activation remained unexplored. The recent development of small molecules directly inhibiting or activating mDia-driven F-actin assembly that supports motility allows for exploration of their role in GBM. We used the formin inhibitor SMIFH2 and mDia agonists IMM-01/-02 and mDia2-DAD peptides, which disrupt autoinhibition, to examine the roles of mDia inactivation versus activation in GBM cell migration and invasion in vitro and in an ex vivo brain slice invasion model. Inhibiting mDia suppressed directional migration and spheroid invasion while preserving intrinsic random migration. mDia agonism abrogated both random intrinsic and directional migration and halted U87 spheroid invasion in ex vivo brain slices. Thus mDia agonism is a superior GBM anti-invasion strategy. We conclude that formin agonism impedes the most dangerous GBM component-tumor spread into surrounding healthy tissue. Formin activation impairs novel aspects of transformed cells and informs the development of anti-GBM invasion strategies. © 2015 Arden et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  8. 33 CFR 118.160 - Vertical clearance gauges.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of the foot marks, read from top to bottom. Each gauge must be installed on the end of the right... directly on the bridge channel pier or pier protection structure if the surface is suitable and has... be marked by black numerals and foot marks on a white background. Paint, if used, must be of good...

  9. 33 CFR 118.160 - Vertical clearance gauges.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of the foot marks, read from top to bottom. Each gauge must be installed on the end of the right... directly on the bridge channel pier or pier protection structure if the surface is suitable and has... be marked by black numerals and foot marks on a white background. Paint, if used, must be of good...

  10. Contemporary Test Validity in Theory and Practice: A Primer for Discipline-Based Education Researchers.

    PubMed

    Reeves, Todd D; Marbach-Ad, Gili

    2016-01-01

    Most discipline-based education researchers (DBERs) were formally trained in the methods of scientific disciplines such as biology, chemistry, and physics, rather than social science disciplines such as psychology and education. As a result, DBERs may have never taken specific courses in the social science research methodology--either quantitative or qualitative--on which their scholarship often relies so heavily. One particular aspect of (quantitative) social science research that differs markedly from disciplines such as biology and chemistry is the instrumentation used to quantify phenomena. In response, this Research Methods essay offers a contemporary social science perspective on test validity and the validation process. The instructional piece explores the concepts of test validity, the validation process, validity evidence, and key threats to validity. The essay also includes an in-depth example of a validity argument and validation approach for a test of student argument analysis. In addition to DBERs, this essay should benefit practitioners (e.g., lab directors, faculty members) in the development, evaluation, and/or selection of instruments for their work assessing students or evaluating pedagogical innovations. © 2016 T. D. Reeves and G. Marbach-Ad. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  11. A quantitative integrated assessment of pollution prevention achieved by integrated pollution prevention control licensing.

    PubMed

    Styles, David; O'Brien, Kieran; Jones, Michael B

    2009-11-01

    This paper presents an innovative, quantitative assessment of pollution avoidance attributable to environmental regulation enforced through integrated licensing, using Ireland's pharmaceutical-manufacturing sector as a case study. Emissions data reported by pharmaceutical installations were aggregated into a pollution trend using an Environmental Emissions Index (EEI) based on Lifecycle Assessment methodologies. Complete sectoral emissions data from 2001 to 2007 were extrapolated back to 1995, based on available data. Production volume data were used to derive a sectoral production index, and determine 'no-improvement' emission trends, whilst questionnaire responses from 20 industry representatives were used to quantify the contribution of integrated licensing to emission avoidance relative to these trends. Between 2001 and 2007, there was a 40% absolute reduction in direct pollution from 27 core installations, and 45% pollution avoidance relative to hypothetical 'no-improvement' pollution. It was estimated that environmental regulation avoided 20% of 'no-improvement' pollution, in addition to 25% avoidance under business-as-usual. For specific emissions, avoidance ranged from 14% and 30 kt a(-1) for CO(2) to 88% and 598 t a(-1) for SO(x). Between 1995 and 2007, there was a 59% absolute reduction in direct pollution, and 76% pollution avoidance. Pollution avoidance was dominated by reductions in emissions of VOCs, SO(x) and NO(x) to air, and emissions of heavy metals to water. Pollution avoidance of 35% was attributed to integrated licensing, ranging from between 8% and 2.9 t a(-1) for phosphorus emissions to water to 49% and 3143 t a(-1) for SO(x) emissions to air. Environmental regulation enforced through integrated licensing has been the major driver of substantial pollution avoidance achieved by Ireland's pharmaceutical sector - through emission limit values associated with Best Available Techniques, emissions monitoring and reporting requirements, and performance targets specified in environmental management plans. This compliant sector offers a positive, but not necessarily typical, case study of IPPC effectiveness.

  12. 25 CFR 20.334 - What happens after I apply?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... SERVICES PROGRAMS Direct Assistance Adult Care Assistance § 20.334 What happens after I apply? (a) The... purchase of service agreements for adult care provided in state or tribally licensed or certified group...

  13. 25 CFR 20.334 - What happens after I apply?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... SERVICES PROGRAMS Direct Assistance Adult Care Assistance § 20.334 What happens after I apply? (a) The... purchase of service agreements for adult care provided in state or tribally licensed or certified group...

  14. 31 CFR 535.502 - Effect of license or authorization.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... direction of the Secretary of the Treasury pursuant to section 203 of the International Emergency Economic... respect to, any property which would not otherwise exist under ordinary principles of law. [44 FR 66833...

  15. Mitigating the effect of development on bats in England with derogation licensing.

    PubMed

    Stone, Emma Louise; Jones, Gareth; Harris, Stephen

    2013-12-01

    The Convention on Biological Diversity has catalyzed worldwide awareness of threats to biological diversity and stimulated global conservation strategies. These have led to national and international legislation and have generated debate about the most effective conservation actions. Under the EU Habitats Directive, all member states are obliged to establish a system for strict protection of species listed in Annex IV(a), which includes all bats. In England, this obligation has resulted in legislation that allows for derogation from strict protection under license, provided activities are undertaken to mitigate any potential negative effects on bat numbers. We used an evidence-based approach to assess the cost-effectiveness of mitigation strategies and the English bat-derogation licensing process as a whole. We analyzed data from 389 bat derogation licenses issued in England from 2003 to 2005 relating to 1776 roosts and 15 species to determine the nature and extent of development and mitigation activities and their effects on bats. Overall the effects of licensed activities on roosts were negative. Despite the level of protection afforded to bats, the majority (68%) of roosts for which derogation licenses were issued were destroyed. There were species-specific differences in the probability of roosts being destroyed, and impacts on roosts did not reflect a species' conservation status. Information provided by licensees was inadequate and inconsistent. Most licensees (67%) failed to submit postdevelopment reports, and postdevelopment monitoring was conducted at only 19% of sites. Despite a minimum of £4.13 million spent on mitigation structures for bats from 2003 to 2005, it was unclear whether the licensing process meets EU obligations. On the basis of our results, we believe there is a need to overhaul the licensing process, to establish a comprehensive, standardized postdevelopment monitoring system, and to demonstrate that mitigation is commensurate with Britain's legal obligations. Mitigando el Efecto del Desarrollo sobre los Murciélagos en Inglaterra con Licencias de Derogación. © 2013 Society for Conservation Biology.

  16. 47 CFR 25.146 - Licensing and operating rules for the non-geostationary orbit Fixed-Satellite Service in the 10.7...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) Single-entry validation equivalent power flux-density, in the space-to-Earth direction, (EPFD down) limits. (i) Provide a set of power flux-density (PFD) masks, on the surface of the Earth, for each space..., in the space-to-Earth direction, (additional operational EPFD down ) limits. (i) Provide a set of...

  17. 76 FR 59392 - Notice of Intent To Grant Exclusive Patent License; Enhanced Energy Group, LLC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-26

    ... inventions, and they are covered by U.S. Patent No. 7,926,275: Closed Brayton Cycle Direct Contact Reactor/ Storage Tank With Chemical Scrubber.//U.S. Patent No. 7,926,276: Closed Cycle Brayton Propulsion System With Direct Heat Transfer.//U.S. Patent No. 7,937,930: Semiclosed Brayton Cycle Power System With...

  18. On the linguistic status of ‘agreement’ in sign languages

    PubMed Central

    LILLO-MARTIN, DIANE; MEIER, RICHARD P.

    2013-01-01

    In signed languages, the arguments of verbs can be marked by a system of verbal modification that has been termed “agreement” (more neutrally, “directionality”). Fundamental issues regarding directionality remain unresolved and the phenomenon has characteristics that call into question its analysis as agreement. We conclude that directionality marks person in American Sign Language, and the ways person marking interacts with syntactic phenomena are largely analogous to morpho-syntactic properties of familiar agreement systems. Overall, signed languages provide a crucial test for how gestural and linguistic mechanisms can jointly contribute to the satisfaction of fundamental aspects of linguistic structure. PMID:23495262

  19. Is Grammar Instruction Beneficial for Heritage Language Learners? Dative Case Marking in Spanish

    ERIC Educational Resources Information Center

    Montrul, Silvina; Bowles, Melissa

    2010-01-01

    Spanish heritage speakers have been shown to have incomplete knowledge of dative case marking with both animate direct objects (also known as differential object marking (DOM) or "a-personal") and dative experiencers with "gustar"-psych verbs in oral and written modes (Montrul, 2004; Montrul & Bowles, in press). In general, Spanish objects that…

  20. 10 CFR 33.17 - Conditions of specific licenses of broad scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... shall not: (1) Conduct tracer studies in the environment involving direct release of byproduct material... required; or (4) Add or cause the addition of byproduct material to any food, beverage, cosmetic, drug, or...

  1. Sandia National Laboratories: News

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  2. Sandia National Laboratories: Locations

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    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  3. Sandia National Laboratories: Careers

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    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  4. Sandia National Laboratories: Mission

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    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  5. Sandia National Laboratories: Research

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  6. Sandia National Laboratories:

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  7. Sandia National Laboratories: Feedback

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  8. Graded Mirror Self-Recognition by Clark's Nutcrackers.

    PubMed

    Clary, Dawson; Kelly, Debbie M

    2016-11-04

    The traditional 'mark test' has shown some large-brained species are capable of mirror self-recognition. During this test a mark is inconspicuously placed on an animal's body where it can only be seen with the aid of a mirror. If the animal increases the number of actions directed to the mark region when presented with a mirror, the animal is presumed to have recognized the mirror image as its reflection. However, the pass/fail nature of the mark test presupposes self-recognition exists in entirety or not at all. We developed a novel mirror-recognition task, to supplement the mark test, which revealed gradation in the self-recognition of Clark's nutcrackers, a large-brained corvid. To do so, nutcrackers cached food alone, observed by another nutcracker, or with a regular or blurry mirror. The nutcrackers suppressed caching with a regular mirror, a behavioural response to prevent cache theft by conspecifics, but did not suppress caching with a blurry mirror. Likewise, during the mark test, most nutcrackers made more self-directed actions to the mark with a blurry mirror than a regular mirror. Both results suggest self-recognition was more readily achieved with the blurry mirror and that self-recognition may be more broadly present among animals than currently thought.

  9. Government use licenses in Thailand: an assessment of the health and economic impacts.

    PubMed

    Yamabhai, Inthira; Mohara, Adun; Tantivess, Sripen; Chaisiri, Kakanang; Teerawattananon, Yot

    2011-08-14

    Between 2006 and 2008, Thailand's Ministry of Public Health (MOPH) granted government use licenses for seven patented drugs in order to improve access to these essential treatments. The decision to grant the government use licenses was contentious both within and beyond the country. In particular, concerns were highlighted that the negative consequences might outweigh the expected benefits of the policy. This study conducted assessments of the health and economic implications of these government use licenses. The health and health-related economic impacts were quantified in terms of i) Quality Adjusted Life Years (QALYs) gained and ii) increased productivity in US dollars (USD) as a result of the increased access to drugs. The study adopted a five-year timeframe for the assessment, commencing from the time of the grant of the government use licenses. Empirical evidence gathered from national databases was used to assess the changes in volume of exports after US Generalized System of Preferences (GSP) withdrawal and level of foreign direct investment (FDI). As a result of the granting of the government use licenses, an additional 84,158 patients were estimated to have received access to the seven drugs over five years. Health gains from the use of the seven drugs compared to their best alternative accounted for 12,493 QALYs gained, which translates into quantifiable incremental benefits to society of USD132.4 million. The government use license on efavirenze was found to have the greatest benefit. In respect of the country's economy, the study found that Thailand's overall exports increased overtime, although exports of the three US GSP withdrawal products to the US did decline. There was also found to be no relationship between the government use licenses and the level of foreign investment over the period 2002 to 2008. The public health benefits of the government use licenses were generally positive. Specifically, the policy helped to increase access to patented drugs, while the impact of the US GSP withdrawal did not adversely affect the overall export status. Because the levels of benefit gained from the government use licenses varied widely between the seven drugs, depending on several factors, this study makes recommendations for the future implementation of the policy in order to maximise benefits.

  10. Government use licenses in Thailand: an assessment of the health and economic impacts

    PubMed Central

    2011-01-01

    Background Between 2006 and 2008, Thailand's Ministry of Public Health (MOPH) granted government use licenses for seven patented drugs in order to improve access to these essential treatments. The decision to grant the government use licenses was contentious both within and beyond the country. In particular, concerns were highlighted that the negative consequences might outweigh the expected benefits of the policy. This study conducted assessments of the health and economic implications of these government use licenses. Methods The health and health-related economic impacts were quantified in terms of i) Quality Adjusted Life Years (QALYs) gained and ii) increased productivity in US dollars (USD) as a result of the increased access to drugs. The study adopted a five-year timeframe for the assessment, commencing from the time of the grant of the government use licenses. Empirical evidence gathered from national databases was used to assess the changes in volume of exports after US Generalized System of Preferences (GSP) withdrawal and level of foreign direct investment (FDI). Results As a result of the granting of the government use licenses, an additional 84,158 patients were estimated to have received access to the seven drugs over five years. Health gains from the use of the seven drugs compared to their best alternative accounted for 12,493 QALYs gained, which translates into quantifiable incremental benefits to society of USD132.4 million. The government use license on efavirenze was found to have the greatest benefit. In respect of the country's economy, the study found that Thailand's overall exports increased overtime, although exports of the three US GSP withdrawal products to the US did decline. There was also found to be no relationship between the government use licenses and the level of foreign investment over the period 2002 to 2008. Conclusions The public health benefits of the government use licenses were generally positive. Specifically, the policy helped to increase access to patented drugs, while the impact of the US GSP withdrawal did not adversely affect the overall export status. Because the levels of benefit gained from the government use licenses varied widely between the seven drugs, depending on several factors, this study makes recommendations for the future implementation of the policy in order to maximise benefits. PMID:21838926

  11. 10 CFR 2.1209 - Findings of fact and conclusions of law.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Findings of fact and conclusions of law. 2.1209 Section 2.1209 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND... directs. ...

  12. 8 CFR 312.2 - Knowledge of history and government of the United States.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... cognitive skills based on the direct effects of the illegal use of drugs will not be considered in... the United States or a clinical psychologist licensed to practice psychology in the United States...

  13. 8 CFR 312.2 - Knowledge of history and government of the United States.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... cognitive skills based on the direct effects of the illegal use of drugs will not be considered in... the United States or a clinical psychologist licensed to practice psychology in the United States...

  14. 8 CFR 312.2 - Knowledge of history and government of the United States.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... cognitive skills based on the direct effects of the illegal use of drugs will not be considered in... the United States or a clinical psychologist licensed to practice psychology in the United States...

  15. 8 CFR 312.2 - Knowledge of history and government of the United States.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... cognitive skills based on the direct effects of the illegal use of drugs will not be considered in... the United States or a clinical psychologist licensed to practice psychology in the United States...

  16. 8 CFR 312.2 - Knowledge of history and government of the United States.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... cognitive skills based on the direct effects of the illegal use of drugs will not be considered in... the United States or a clinical psychologist licensed to practice psychology in the United States...

  17. 31 CFR 515.575 - Humanitarian projects.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CUBAN ASSETS CONTROL REGULATIONS Licenses... Cuba not otherwise covered by this part that are designed to directly benefit the Cuban people. Such... intended to benefit legitimately independent civil society groups; environmental projects; projects...

  18. 31 CFR 515.575 - Humanitarian projects.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CUBAN ASSETS CONTROL REGULATIONS Licenses... Cuba not otherwise covered by this part that are designed to directly benefit the Cuban people. Such... intended to benefit legitimately independent civil society groups; environmental projects; projects...

  19. 31 CFR 515.575 - Humanitarian projects.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CUBAN ASSETS CONTROL REGULATIONS Licenses... Cuba not otherwise covered by this part that are designed to directly benefit the Cuban people. Such... intended to benefit legitimately independent civil society groups; environmental projects; projects...

  20. 31 CFR 515.575 - Humanitarian projects.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY CUBAN ASSETS CONTROL REGULATIONS Licenses... Cuba not otherwise covered by this part that are designed to directly benefit the Cuban people. Such... intended to benefit legitimately independent civil society groups; environmental projects; projects...

  1. 78 FR 46932 - Notice of Availability of Government-Owned Inventions; Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-02

    ... APPARATUS, Issued on June 18, 2013//U.S. Patent Number 8,477,308: POLARIZED, SPECULAR REFLECTOMETER APPARATUS, Issued on July 2, 2013. ADDRESSES: Requests for copies of the inventions cited should be directed...

  2. Sandia National Laboratories: Employee & Retiree Resources: Emergency

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    ; Technology Defense Systems & Assessments About Defense Systems & Assessments Program Areas Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  3. Sandia National Laboratories: Search Results

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    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  4. Sandia National Laboratories: Sandia National Laboratories: Missions:

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  5. Sandia National Laboratories: About Sandia: Community Involvement:

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  6. Sandia National Laboratories: Social Media

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  7. Sandia National Laboratories: Visiting Research Scholars

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  8. Sandia National Laboratories: News: Videos

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  9. Sandia National Laboratories: About Sandia

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  10. Sandia National Laboratories: News: Image Gallery

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  11. Sandia National Laboratories: Research: Biodefense

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  12. Sandia National Laboratories: Privacy and Security

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  13. Sandia National Laboratories: Research: Research Foundations: Nanodevices

    Science.gov Websites

    ; Technology Defense Systems & Assessments About Defense Systems & Assessments Program Areas Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  14. Sandia National Laboratories: Sandia Digital Media

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  15. Sandia National Laboratories: Careers: Special Programs

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  16. Sandia National Laboratories: Cooperative Monitoring Center

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  17. Sandia National Laboratories: Cooperative Research and Development

    Science.gov Websites

    ; Technology Defense Systems & Assessments About Defense Systems & Assessments Program Areas Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  18. Sandia National Laboratories: Research: Bioscience

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  19. Sandia National Laboratories: Integrated Military Systems

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  20. Decoupled direct tracking control system based on use of a virtual track for multilayer disk with a separate guide layer

    NASA Astrophysics Data System (ADS)

    Tanaka, Yukinobu; Ogata, Takeshi; Imagawa, Seiji

    2015-09-01

    We developed a decoupled direct tracking control system for multilayer optical disk that uses a separate guide layer. Data marks are recorded on a recording layer immediately above the guide layer by using two spatially separated spots with different wavelengths. Accurate data mark recording requires that the relative positions of the corresponding spots on the recording layer and guide layer are maintained. However, a disk tilt can shift their relative positions and cause previously recorded data marks to be overwritten. Additionally, a two-input/two-output control system is susceptible to mutual interference phenomenon between the two outputs, which can destabilize tracking control. A tracking control system based on use of data marks previously recorded as a virtual track has been developed that prevents spot shifting and mutual interference even if the disk tilt reaches 0.7°, thereby preventing overwriting.

  1. Application of a liquid crystal spatial light modulator to laser marking.

    PubMed

    Parry, Jonathan P; Beck, Rainer J; Shephard, Jonathan D; Hand, Duncan P

    2011-04-20

    Laser marking is demonstrated using a nanosecond (ns) pulse duration laser in combination with a liquid crystal spatial light modulator to generate two-dimensional patterns directly onto thin films and bulk metal surfaces. Previous demonstrations of laser marking with such devices have been limited to low average power lasers. Application in the ns regime enables more complex, larger scale marks to be generated with more widely available and industrially proven laser systems. The dynamic nature of the device is utilized to improve mark quality by reducing the impact of the inherently speckled intensity distribution across the generated image and reduce thermal effects in the marked surface. © 2011 Optical Society of America

  2. Predictors of performance in an ophthalmology residency program.

    PubMed

    Alfawaz, Abdullah M; Al-Dahmash, Saad A

    2016-06-01

    To assess the value of current selection criteria and additional factors as predictors of performance in an ophthalmology residency training program. A retrospective study. Data were collected from the files of 166 residents who were collectively trained in an ophthalmology residency program from 2000 to 2013. The program's selection criteria included medical school grade point average (GPA), Saudi licensing examination (SLE) score, multiple-choice question ophthalmology selection (MCQ) examination score, and interview mark. Indicators of performance included average scores in the promotion examination for 4 years of training (average R), King Saud University fellowship examination (KSU) score, and Saudi Board in Ophthalmology examination (SBO) score. An average of KSU and SBO scores was also used as a performance indicator. Times of program completion and average performance score across all years in the residency program were used as second-level indicators of performance. There were strong correlations between the MCQ examination score and each training performance indicator (average R, KSU score, SBO score, and average of KSU and SBO scores; p = 0.002, 0.008, 0.05, and 0.002, respectively). The interview mark correlated well with average R (p = 0.001) but not with other indicators. The MCQ examination score and the interview mark were the only predictors of second-level indicators of performance (p = 0.009 and 0.029, respectively). The MCQ examination score and interview mark were the 2 best predictors of performance as an ophthalmology resident. GPA and SLE score were poor predictors of performance. Copyright © 2016 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.

  3. Front lighted optical tooling method and apparatus

    DOEpatents

    Stone, William J.

    1985-06-18

    An optical tooling method and apparatus uses a front lighted shadowgraphic technique to enhance visual contrast of reflected light. The apparatus includes an optical assembly including a fiducial mark, such as cross hairs, reflecting polarized light with a first polarization, a polarizing element backing the fiducial mark and a reflective surface backing the polarizing element for reflecting polarized light bypassing the fiducial mark and traveling through the polarizing element. The light reflected by the reflecting surface is directed through a second pass of the polarizing element toward the frontal direction with a polarization differing from the polarization of the light reflected by the fiducial mark. When used as a tooling target, the optical assembly may be mounted directly to a reference surface or may be secured in a mounting, such as a magnetic mounting. The optical assembly may also be mounted in a plane defining structure and used as a spherometer in conjunction with an optical depth measuring instrument. A method of measuring a radius of curvature of an unknown surface includes positioning the spherometer on a surface between the surface and a depth measuring optical instrument. As the spherometer is frontally illuminated, the distance from the depth measuring instrument to the fiducial mark and the underlying surface are alternately measured and the difference in these measurements is used as the sagittal height to calculate a radius of curvature.

  4. Regulating the tobacco retail environment: beyond reducing sales to minors.

    PubMed

    Chapman, S; Freeman, B

    2009-12-01

    The World Health Organization Framework Convention on Tobacco Control (FCTC) has little to say about the regulation of tobacco retailing, with most research and policy debate having been restricted to confining sales to adults and removing advertising displays, including packs. Tobacco retailing is largely unregulated, reflecting the historical regulatory trivialisation of tobacco products, now demonstrably anachronistic with the advent of near global support for the FCTC. This situation contrasts markedly with the regulation of pharmaceuticals, and many other goods and services subject to a wide variety of restrictions. This review proposes that the international tobacco control community should open up debate on retail regulation to examine the suitability of principles long accepted in pharmaceutical regulation. These include: restrictions on the number and location of tobacco retail outlets, the banning of tobacco retail displays, floor (minimum) price controls, restricting the amount of tobacco smokers could purchase over a given time and loss of retail licensure following breaches of any of the conditions of license. It proposes that retail licenses should be heavily restricted and tradable, becoming valuable commercial assets, where the threat of loss or revocation would act as an incentive for strict adherence to the measures proposed.

  5. Newer Vaccines against Mosquito-borne Diseases.

    PubMed

    Aggarwal, Anju; Garg, Neha

    2018-02-01

    Mosquitos are responsible for a number of protozoal and viral diseases. Malaria, dengue, Japanese encephalitis (JE) and chikungunya epidemics occur commonly all over the world, leading to marked mortality and morbidity in children. Zika, Yellow fever and West Nile fever are others requiring prevention. Environmental control and mosquito bite prevention are useful in decreasing the burden of disease but vaccination has been found to be most cost-effective and is the need of the hour. RTS,S/AS01 vaccine is the first malaria vaccine being licensed for use against P. falciparum malaria. Dengvaxia (CYD-TDV) against dengue was licensed first in Mexico in 2015. A Vero-cell derived, inactivated and alum-adjuvanted JE vaccine based on the SA14-14-2 strain was approved in 2009 in North America, Australia and various European countries. It can be used from 2 mo of age. In India, immunization is carried out in endemic regions at 1 y of age. Another inactivated Vero-cell culture derived Kolar strain, 821564XY, JE vaccine is being used in India. Candidate vaccines against dengue, chikungunya and West Nile fever are been discussed. A continued research and development of new vaccines are required for controlling these mosquito-borne diseases.

  6. Variation in assessment and standard setting practices across UK undergraduate medicine and the need for a benchmark

    PubMed Central

    2015-01-01

    Objectives The principal aim of this study is to provide an account of variation in UK undergraduate medical assessment styles and corresponding standard setting approaches with a view to highlighting the importance of a UK national licensing exam in recognizing a common standard. Methods Using a secure online survey system, response data were collected during the period 13 - 30 January 2014 from selected specialists in medical education assessment, who served as representatives for their respective medical schools. Results Assessment styles and corresponding choices of standard setting methods vary markedly across UK medical schools. While there is considerable consensus on the application of compensatory approaches, individual schools display their own nuances through use of hybrid assessment and standard setting styles, uptake of less popular standard setting techniques and divided views on norm referencing. Conclusions The extent of variation in assessment and standard setting practices across UK medical schools validates the concern that there is a lack of evidence that UK medical students achieve a common standard on graduation. A national licensing exam is therefore a viable option for benchmarking the performance of all UK undergraduate medical students. PMID:26520472

  7. Prevalence and correlates of street racing among Ontario high school students.

    PubMed

    Vingilis, Evelyn; Smart, Reginald G; Mann, Robert E; Paglia-Boak, Angela; Stoduto, Gina; Adlaf, Edward M

    2011-10-01

    This study examined the prevalence and correlates of street racing among adolescents derived from the 2009 Ontario Student Drug Use and Health Survey (OSDUHS), an epidemiological survey of students in Ontario, Canada. The key response variable, self-reported street racing in past year, was examined in relation to grade level, rural/urban, school marks, cannabis use, drinking and driving, cannabis use and driving, and property, physical, drugs, and weapons delinquencies. All survey estimates were weighted, and variance and statistical tests were corrected for the complex sampling design. Of the 3053 9th- to 12th-graders (66% response rate), 5.6 percent of high-schoolers (an estimated 42,000 in the province) and (20.4% of grade 11 and 12 students with an advanced-level or full license) reported driving a car, truck, or sport utility vehicle (SUV) in a street race in the 12 months before the survey. Logistic regression analysis of the advanced-level or fully licensed students in grades 11 and 12 found that males compared to females and students in grade 11 compared to students in grade 12 had significantly higher adjusted odds of street racing. Supportive of problem behavior theory, students who reported property and drug delinquencies compared to students not engaging in these delinquencies also had significantly higher adjusted odds of street racing. This first population-based study in North America suggested that the prevalence of street racing at 1 in 5 of advanced or fully licensed high-schoolers in grades 11 and 12 poses significant public health concerns, especially related to the potential for unintentional injury.

  8. Differential phosphorylation signals control endocytosis of GPR15.

    PubMed

    Okamoto, Yukari; Shikano, Sojin

    2017-08-15

    GPR15 is an orphan G protein-coupled receptor (GPCR) that serves for an HIV coreceptor and was also recently found as a novel homing receptor for T-cells implicated in colitis. We show that GPR15 undergoes a constitutive endocytosis in the absence of ligand. The endocytosis was clathrin dependent and partially dependent on β-arrestin in HEK293 cells, and nearly half of the internalized GPR15 receptors were recycled to the plasma membrane. An Ala mutation of the distal C-terminal Arg-354 or Ser-357, which forms a consensus phosphorylation site for basophilic kinases, markedly reduced the endocytosis, whereas phosphomimetic mutation of Ser-357 to Asp did not. Ser-357 was phosphorylated in vitro by multiple kinases, including PKA and PKC, and pharmacological activation of these kinases enhanced both phosphorylation of Ser-357 and endocytosis of GPR15. These results suggested that Ser-357 phosphorylation critically controls the ligand-independent endocytosis of GPR15. The functional role of Ser-357 in endocytosis was distinct from that of a conserved Ser/Thr cluster in the more proximal C-terminus, which was responsible for the β-arrestin- and GPCR kinase-dependent endocytosis of GPR15. Thus phosphorylation signals may differentially control cell surface density of GPR15 through endocytosis. © 2017 Okamoto and Shikano. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  9. Broadening Participation in Biology Education Research: Engaging Community College Students and Faculty.

    PubMed

    Schinske, Jeffrey N; Balke, Virginia L; Bangera, M Gita; Bonney, Kevin M; Brownell, Sara E; Carter, Robert S; Curran-Everett, Douglas; Dolan, Erin L; Elliott, Samantha L; Fletcher, Linnea; Gonzalez, Beatriz; Gorga, Joseph J; Hewlett, James A; Kiser, Stacey L; McFarland, Jenny L; Misra, Anjali; Nenortas, Apryl; Ngeve, Smith M; Pape-Lindstrom, Pamela A; Seidel, Shannon B; Tuthill, Matthew C; Yin, Yue; Corwin, Lisa A

    2017-01-01

    Nearly half of all undergraduates are enrolled at community colleges (CCs), including the majority of U.S. students who represent groups underserved in the sciences. Yet only a small minority of studies published in discipline-based education research journals address CC biology students, faculty, courses, or authors. This marked underrepresentation of CC biology education research (BER) limits the availability of evidence that could be used to increase CC student success in biology programs. To address this issue, a diverse group of stakeholders convened at the Building Capacity for Biology Education Research at Community Colleges meeting to discuss how to increase the prevalence of CC BER and foster participation of CC faculty as BER collaborators and authors. The group identified characteristics of CCs that make them excellent environments for studying biology teaching and learning, including student diversity and institutional cultures that prioritize teaching, learning, and assessment. The group also identified constraints likely to impede BER at CCs: limited time, resources, support, and incentives, as well as misalignment between doing research and CC faculty identities as teachers. The meeting culminated with proposing strategies for faculty, administrators, journal editors, scientific societies, and funding agencies to better support CC BER. © 2017 J. N. Schinske et al. CBE—Life Sciences Education © 2017 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  10. Characteristics of on-road driving performance of persons with central vision loss who use bioptic telescopes.

    PubMed

    Wood, Joanne M; McGwin, Gerald; Elgin, Jennifer; Searcey, Karen; Owsley, Cynthia

    2013-05-01

    To compare the on-road driving performance of visually impaired drivers using bioptic telescopes with age-matched controls. Participants included 23 persons (mean age = 33 ± 12 years) with visual acuity of 20/63 to 20/200 who were legally licensed to drive through a state bioptic driving program, and 23 visually normal age-matched controls (mean age = 33 ± 12 years). On-road driving was assessed in an instrumented dual-brake vehicle along 14.6 miles of city, suburban, and controlled-access highways. Two backseat evaluators independently rated driving performance using a standardized scoring system. Vehicle control was assessed through vehicle instrumentation and video recordings used to evaluate head movements, lane-keeping, pedestrian detection, and frequency of bioptic telescope use. Ninety-six percent (22/23) of bioptic drivers and 100% (23/23) of controls were rated as safe to drive by the evaluators. There were no group differences for pedestrian detection, or ratings for scanning, speed, gap judgments, braking, indicator use, or obeying signs/signals. Bioptic drivers received worse ratings than controls for lane position and steering steadiness and had lower rates of correct sign and traffic signal recognition. Bioptic drivers made significantly more right head movements, drove more often over the right-hand lane marking, and exhibited more sudden braking than controls. Drivers with central vision loss who are licensed to drive through a bioptic driving program can display proficient on-road driving skills. This raises questions regarding the validity of denying such drivers a license without the opportunity to train with a bioptic telescope and undergo on-road evaluation.

  11. Comparative Plasmodium gene overexpression reveals distinct perturbation of sporozoite transmission by profilin.

    PubMed

    Sato, Yuko; Hliscs, Marion; Dunst, Josefine; Goosmann, Christian; Brinkmann, Volker; Montagna, Georgina N; Matuschewski, Kai

    2016-07-15

    Plasmodium relies on actin-based motility to migrate from the site of infection and invade target cells. Using a substrate-dependent gliding locomotion, sporozoites are able to move at fast speed (1-3 μm/s). This motility relies on a minimal set of actin regulatory proteins and occurs in the absence of detectable filamentous actin (F-actin). Here we report an overexpression strategy to investigate whether perturbations of F-actin steady-state levels affect gliding locomotion and host invasion. We selected two vital Plasmodium berghei G-actin-binding proteins, C-CAP and profilin, in combination with three stage-specific promoters and mapped the phenotypes afforded by overexpression in all three extracellular motile stages. We show that in merozoites and ookinetes, additional expression does not impair life cycle progression. In marked contrast, overexpression of C-CAP and profilin in sporozoites impairs circular gliding motility and salivary gland invasion. The propensity for productive motility correlates with actin accumulation at the parasite tip, as revealed by combinations of an actin-stabilizing drug and transgenic parasites. Strong expression of profilin, but not C-CAP, resulted in complete life cycle arrest. Comparative overexpression is an alternative experimental genetic strategy to study essential genes and reveals effects of regulatory imbalances that are not uncovered from deletion-mutant phenotyping. © 2016 Sato et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  12. Direct, Operational Field Test Evaluation, Human Factors

    DOT National Transportation Integrated Search

    1998-08-01

    IN THIS EXPERIMENT, 32 LICENSED DRIVERS (16 YOUNG, 16 OLD) DROVE ON AN EXPRESSWAY. ON EACH TRIAL (96 PER SUBJECT), 1 TO 3 TRAFFIC MESSAGES CONTAINING 6 TO 14 ITEMS WERE PRESENTED. (L-94 EASTBOUND AT SOUTHFIELD FREEWAY, CONTINUING CONSTRUCTION, RIGHT ...

  13. 76 FR 35922 - Notice of Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-20

    ... CONTACT: Harriet Karagiannis, Regulatory Guide Development Branch, Division of Engineering, Office of... direct the use of individual monitoring devices. In addition, 10 CFR part 34, ``Licenses for Industrial Radiography and Radiation Safety Requirements for Industrial Radiographic Operations,'' includes a specific...

  14. 75 FR 15701 - Georgia Power Company; Notice of Application for Amendment of License and Soliciting Comments...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-30

    ... Contact: Any questions regarding this notice should be directed to Isis Johnson, Telephone (202) 502-6346, and e-mail: isis[email protected] . j. Deadline for filing comments, motions to intervene, and protest...

  15. Sandia National Laboratories: News: Publications: Environmental Reports

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  16. Sandia National Laboratories: Sandia National Laboratories: News: Events

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  17. Sandia National Laboratories: About Sandia: Environmental Responsibility

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  18. Sandia National Laboratories: About Sandia: Community Involvement

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  19. Sandia National Laboratories: News: Publications: HPC Reports

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  20. Sandia National Laboratories: Community Involvement: Volunteer Programs

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  1. Sandia National Laboratories: National Security Missions: International

    Science.gov Websites

    Weapons Safety & Security Weapons Science & Technology Defense Systems & Assessments About Directed Research & Development Technology Deployment Centers Working With Sandia Working With Sandia Licensing & Technology Transfer Browse Technology Portfolios Technology Partnerships Business, Industry

  2. Sandia National Laboratories: News: Search Sandia Publications

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  3. Sandia National Laboratories: Working with Sandia: Small Business

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  4. Sandia National Laboratories: Microsystems Science & Technology Center

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  5. Sandia National Laboratories: News: Publications: Strategic Plan

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  6. Sandia National Laboratories: News: Media Resources: Media Contacts

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  7. Sandia National Laboratories: Sandia Enabled Communications and

    Science.gov Websites

    Weapons Safety & Security Weapons Science & Technology Defense Systems & Assessments About Directed Research & Development Technology Deployment Centers Working With Sandia Working With Sandia Licensing & Technology Transfer Browse Technology Portfolios Technology Partnerships Business, Industry

  8. Sandia National Laboratories: Employee & Retiree Resources: Technical

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  9. Sandia National Laboratories: Z Pulsed Power Facility

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  10. Sandia National Laboratories: National Security Missions: Defense Systems

    Science.gov Websites

    ; Technology Defense Systems & Assessments About Defense Systems & Assessments Program Areas Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  11. Sandia National Laboratories: Advanced Simulation and Computing

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  12. Sandia National Laboratories: News: Publications: Annual Report

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  13. Sandia National Laboratories: Employee & Retiree Resources: Remote Access

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  14. Land mobile spectrum utilization: San Francisco, California and Chicago, Illinois

    NASA Astrophysics Data System (ADS)

    Reed, L. D.

    1980-08-01

    Radio frequency utilization by Federal Communication Commission licenses in the San Francisco and Chicago urbanized areas is described. The license include among others: police and fire departments; hospitals; public utilities; marine; and common carrier users. The extent of frequency utilization is described in terms of four occupancy categorizations (zero, low, substantial and very high). The rationale for these categories and their relationship to measured usage data is given. Summary tables enable direct comparison of the use by various individual, radio services, e.g., police, business, taxicab, etc. Separate analyses are given for utilization by each of the land mobile radio services and for each frequency band.

  15. 41 CFR 60-741.3 - Exceptions to the definitions of “individual with a disability” and “qualified individual with a...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... term does not include the use of a drug taken under supervision by a licensed health care professional..., would constitute a direct threat to property or to the health or safety of the individual or others. (2... eliminate or reduce the direct threat to property or the health or safety of the individual or others posed...

  16. 41 CFR 60-741.3 - Exceptions to the definitions of “individual with a disability” and “qualified individual with a...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... term does not include the use of a drug taken under supervision by a licensed health care professional..., would constitute a direct threat to property or to the health or safety of the individual or others. (2... eliminate or reduce the direct threat to property or the health or safety of the individual or others posed...

  17. 41 CFR 60-741.3 - Exceptions to the definitions of “individual with a disability” and “qualified individual with a...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... term does not include the use of a drug taken under supervision by a licensed health care professional..., would constitute a direct threat to property or to the health or safety of the individual or others. (2... eliminate or reduce the direct threat to property or the health or safety of the individual or others posed...

  18. All-Wales licensed premises intervention (AWLPI): a randomised controlled trial to reduce alcohol-related violence

    PubMed Central

    2014-01-01

    Background Alcohol-related violence in and in the vicinity of licensed premises continues to place a considerable burden on the United Kingdom’s (UK) health services. Robust interventions targeted at licensed premises are therefore required to reduce the costs of alcohol-related harm. Previous evaluations of interventions in licensed premises have a number of methodological limitations and none have been conducted in the UK. The aim of the trial was to determine the effectiveness of the Safety Management in Licensed Environments intervention designed to reduce alcohol-related violence in licensed premises, delivered by Environmental Health Officers, under their statutory authority to intervene in cases of violence in the workplace. Methods/Design A national randomised controlled trial, with licensed premises as the unit of allocation. Premises were identified from all 22 Local Authorities in Wales. Eligible premises were those with identifiable violent incidents on premises, using police recorded violence data. Premises were allocated to intervention or control by optimally balancing by Environmental Health Officer capacity in each Local Authority, number of violent incidents in the 12 months leading up to the start of the project and opening hours. The primary outcome measure is the difference in frequency of violence between intervention and control premises over a 12 month follow-up period, based on a recurrent event model. The trial incorporates an embedded process evaluation to assess intervention implementation, fidelity, reach and reception, and to interpret outcome effects, as well as investigate its economic impact. Discussion The results of the trial will be applicable to all statutory authorities directly involved with managing violence in the night time economy and will provide the first formal test of Health and Safety policy in this environment. If successful, opportunities for replication and generalisation will be considered. Trial registration UKCRN 14077; ISRCTN78924818. PMID:24405575

  19. Virtual Tool Mark Generation for Efficient Striation Analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ekstrand, Laura; Zhang, Song; Grieve, Taylor

    2014-02-16

    This study introduces a tool mark analysis approach based upon 3D scans of screwdriver tip and marked plate surfaces at the micrometer scale from an optical microscope. An open-source 3D graphics software package is utilized to simulate the marking process as the projection of the tip's geometry in the direction of tool travel. The edge of this projection becomes a virtual tool mark that is compared to cross-sections of the marked plate geometry using the statistical likelihood algorithm introduced by Chumbley et al. In a study with both sides of six screwdriver tips and 34 corresponding marks, the method distinguishedmore » known matches from known nonmatches with zero false-positive matches and two false-negative matches. For matches, it could predict the correct marking angle within ±5–10°. Individual comparisons could be made in seconds on a desktop computer, suggesting that the method could save time for examiners.« less

  20. Direct fluorescent-dye labeling of α-tubulin in mammalian cells for live cell and superresolution imaging.

    PubMed

    Schvartz, Tomer; Aloush, Noa; Goliand, Inna; Segal, Inbar; Nachmias, Dikla; Arbely, Eyal; Elia, Natalie

    2017-10-15

    Genetic code expansion and bioorthogonal labeling provide for the first time a way for direct, site-specific labeling of proteins with fluorescent-dyes in live cells. Although the small size and superb photophysical parameters of fluorescent-dyes offer unique advantages for high-resolution microscopy, this approach has yet to be embraced as a tool in live cell imaging. Here we evaluated the feasibility of this approach by applying it for α-tubulin labeling. After a series of calibrations, we site-specifically labeled α-tubulin with silicon rhodamine (SiR) in live mammalian cells in an efficient and robust manner. SiR-labeled tubulin successfully incorporated into endogenous microtubules at high density, enabling video recording of microtubule dynamics in interphase and mitotic cells. Applying this labeling approach to structured illumination microscopy resulted in an increase in resolution, highlighting the advantages in using a smaller, brighter tag. Therefore, using our optimized assay, genetic code expansion provides an attractive tool for labeling proteins with a minimal, bright tag in quantitative high-resolution imaging. © 2017 Schvartz et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  1. Computer-assisted learning in human and dental medicine.

    PubMed

    Höhne, S; Schumann, R R

    2004-04-01

    This article describes the development and application of new didactic methods for use in computer-assisted teaching and learning systems for training doctors and dentists. Taking the Meducase project as an example, didactic models and their technological implementation are explained, together with the limitations of imparting knowledge with the "new media". In addition, legal concepts for a progressive, pragmatic, and innovative distribution of knowledge to undergraduate students are presented. In conclusion, potential and visions for the wide use of electronic learning in the German and European universities in the future are discussed. Self-directed learning (SDL) is a key component in both undergraduate education and lifelong learning for medical practitioners. E-learning can already be used to promote SDL at undergraduate level. The Meducase project uses self-directed, constructive, case- and problem-oriented learning within a learning platform for medical and dental students. In the long run, e-learning programs can only be successful in education if there is consistent analysis and implementation of value-added factors and the development and use of media-didactic concepts matched to electronic learning. The use of innovative forms of licensing - open source licenses for software and similar licenses for content - facilitates continuous, free access to these programs for all students and teachers. These legal concepts offer the possibility of innovative knowledge distribution, quality assurance and standardization across specializations, university departments, and possibly even national borders.

  2. Validation of stereophotogrammetry of the human torso.

    PubMed

    Lee, Juhun; Kawale, Manas; Merchant, Fatima A; Weston, June; Fingeret, Michelle C; Ladewig, Dianne; Reece, Gregory P; Crosby, Melissa A; Beahm, Elisabeth K; Markey, Mia K

    2011-02-15

    The objective of this study was to determine if measurements of breast morphology computed from three-dimensional (3D) stereophotogrammetry are equivalent to traditional anthropometric measurements obtained directly on a subject using a tape measure. 3D torso images of 23 women ranged in age from 36 to 63 who underwent or were scheduled for breast reconstruction surgery were obtained using a 3dMD torso system (3Q Technologies Inc., Atlanta, GA). Two different types (contoured and line-of-sight distances) of a total of nine distances were computed from 3D images of each participant. Each participant was photographed twice, first without fiducial points marked (referred to as unmarked image) and second with fiducial points marked prior to imaging (referred to as marked image). Stereophotogrammetry was compared to traditional direct anthropometry, in which measurements were taken with a tape measure on participants. Three statistical analyses were used to evaluate the agreement between stereophotogrammetry and direct anthropometry. Seven out of nine distances showed excellent agreement between stereophotogrammetry and direct anthropometry (both marked and unmarked images). In addition, stereophotogrammetry from the unmarked image was equivalent to that of the marked image (both line-of-sight and contoured distances). A lower level of agreement was observed for some measures because of difficulty in localizing more vaguely defined fiducial points, such as lowest visible point of breast mound, and inability of the imaging system in capturing areas obscured by the breast, such as the inframammary fold. Stereophotogrammetry from 3D images obtained from the 3dMD torso system is effective for quantifying breast morphology. Tools for surgical planning and evaluation based on stereophotogrammetry have the potential to improve breast surgery outcomes.

  3. Free Electron Laser Induced Forward Transfer Method of Biomaterial for Marking

    NASA Astrophysics Data System (ADS)

    Suzuki, Kaoru

    Biomaterial, such as chitosan, poly lactic acid, etc., containing fluorescence agent was deposited onto biology hard tissue, such as teeth, fingernail of dog or cat, or sapphire substrate by free electron laser induced forward transfer method for direct write marking. Spin-coated biomaterial with fluorescence agent of rhodamin-6G or zinc phthalochyamine target on sapphire plate was ablated by free electron laser (resonance absorption wavelength of biomaterial : 3380 nm). The influence of the spin-coating film-forming temperature on hardness and adhesion strength of biomaterial is particularly studied. Effect of resonance excitation of biomaterial target by turning free electron laser was discussed to damage of biomaterial, rhodamin-6G or zinc phtarochyamine for direct write marking

  4. KSC-2011-1212

    NASA Image and Video Library

    2011-01-27

    CAPE CANAVERAL, Fla. -- Pictured near the Space Mirror Memorial at the Kennedy Space Center Visitor Complex in Florida are the members of the NASA family who lost their lives while furthering the cause of exploration and discovery. The memorial honors 24 United States astronauts, including the crew members of space shuttles Columbia and Challenger, Apollo 1, and those who died in training and commercial airplane accidents. The memorial is a project of the Astronauts Memorial Foundation and was paid for by Florida residents who purchased special Challenger mission automobile license plates. 2011 marks the 25th anniversary of the loss of Challenger, which broke apart over the Atlantic Ocean 73 seconds into flight on Jan. 28, 1986. Photo credit: NASA/Kim Shiflett

  5. Georgia's Teacher Performance Assessment

    ERIC Educational Resources Information Center

    Fenton, Anne Marie; Wetherington, Pamela

    2016-01-01

    Like most states, Georgia until recently depended on an assessment of content knowledge to award teaching licenses, along with a licensure recommendation from candidates' educator preparation programs. While the content assessment reflected candidates' grasp of subject matter, licensure decisions did not hinge on direct, statewide assessment of…

  6. Sandia National Laboratories: What Sandia Looks For In Our Suppliers

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  7. Sandia National Laboratories: Working with Sandia: What Does Sandia Buy?

    Science.gov Websites

    Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  8. Sandia National Laboratories: Sandia inks pact with Fire and Rescue

    Science.gov Websites

    ; Technology Defense Systems & Assessments About Defense Systems & Assessments Program Areas Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

  9. 31 CFR 596.201 - Prohibited financial transactions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY TERRORISM LIST GOVERNMENTS SANCTIONS..., orders, directives, rulings, instructions, licenses, or otherwise, no United States person, on or after... terrorism, shall engage in a financial transaction with the government of that country. (b) Countries...

  10. Crossing boundaries: a comprehensive survey of medical licensing laws and guidelines regulating the interstate practice of pathology.

    PubMed

    Hiemenz, Matthew C; Leung, Stanley T; Park, Jason Y

    2014-03-01

    In the United States, recent judicial interpretation of interstate licensure laws has found pathologists guilty of malpractice and, more importantly, the criminal practice of medicine without a license. These judgments against pathologists highlight the need for a timely and comprehensive survey of licensure requirements and laws regulating the interstate practice of pathology. For all 50 states, each state medical practice act and state medical board website was reviewed. In addition, each medical board was directly contacted by electronic mail, telephone, or US registered mail for information regarding specific legislation or guidelines related to the interstate practice of pathology. On the basis of this information, states were grouped according to similarities in legislation and medical board regulations. This comprehensive survey has determined that states define the practice of pathology on the basis of the geographic location of the patient at the time of surgery or phlebotomy. The majority of states (n=32) and the District of Columbia allow for a physician with an out-of-state license to perform limited consultation to a physician with the specific state license. Several states (n=5) prohibit physicians from consultation without a license for the specific state. Overall, these results reveal the heterogeneity of licensure requirements between states. Pathologists who either practice in multiple states, send cases to out-of-state consultants, or serve as consultants themselves should familiarize themselves with the medical licensure laws of the states from which they receive or send cases.

  11. Fuel-Air Injection Effects on Combustion in Cavity-Based Flameholders in a Supersonic Flow

    DTIC Science & Technology

    2005-03-01

    both fuel and air provided additional capability to tune the cavity such that a more stable decentralized flame results. The addition of air...Mark Gruber of AFRL/PRAS and Mr. Mark Hsu of Innovative Scientific Solutions Inc. for both the support and latitude provided to me in this endeavor...addition of direct air injection to cavity combustion. Direct injection of both fuel and air provided additional capability to tune the cavity such that a

  12. Modelling abstraction licensing strategies ahead of the UK's water abstraction licensing reform

    NASA Astrophysics Data System (ADS)

    Klaar, M. J.

    2012-12-01

    Within England and Wales, river water abstractions are licensed and regulated by the Environment Agency (EA), who uses compliance with the Environmental Flow Indicator (EFI) to ascertain where abstraction may cause undesirable effects on river habitats and species. The EFI is a percentage deviation from natural flow represented using a flow duration curve. The allowable percentage deviation changes with different flows, and also changes depending on an assessment of the sensitivity of the river to changes in flow (Table 1). Within UK abstraction licensing, resource availability is expressed as a surplus or deficit of water resources in relation to the EFI, and utilises the concept of 'hands-off-flows' (HOFs) at the specified flow statistics detailed in Table 1. Use of a HOF system enables abstraction to cease at set flows, but also enables abstraction to occur at periods of time when more water is available. Compliance at low flows (Q95) is used by the EA to determine the hydrological classification and compliance with the Water Framework Directive (WFD) for identifying waterbodies where flow may be causing or contributing to a failure in good ecological status (GES; Table 2). This compliance assessment shows where the scenario flows are below the EFI and by how much, to help target measures for further investigation and assessment. Currently, the EA is reviewing the EFI methodology in order to assess whether or not it can be used within the reformed water abstraction licensing system which is being planned by the Department for Environment, Food and Rural Affairs (DEFRA) to ensure the licensing system is resilient to the challenges of climate change and population growth, while allowing abstractors to meet their water needs efficiently, and better protect the environment. In order to assess the robustness of the EFI, a simple model has been created which allows a number of abstraction, flow and licensing scenarios to be run to determine WFD compliance using the current EFI method, as well as allowing alternative licensing scenarios (e.g. using alternative flow statistics, flow periods and ASB bands) to be tested. Initial analysis suggests that the model is a useful tool in visualising licensing options ahead of the licensing reform.Table 1: Percentage allowable abstraction from natural flows at different abstraction sensitivity bands (ASB), as allowed under the EFI method; Table 2: Current framework used to determine flows which support GES as part of the EU WFD;

  13. Science communication: a career where PhDs can make a difference.

    PubMed

    Irion, Robert

    2015-02-15

    Among careers for biologists with PhDs, science communication is one of the most diverse and rewarding pathways. Myriad options exist, from traditional journalism to new media, from writing for specialists to working in public outreach. Textbooks, mass-market books, and freelance writing that combines many of these pursuits are all viable choices. Communicating about science allows researchers to step away from the minutiae of a subdiscipline and to once again explore the breadth of science more fully through an ever-evolving array of stories. A doctoral degree can confer distinct advantages in the eyes of prospective editors and employers. Here I describe those advantages, possible career directions, and steps toward making such a transition. © 2015 Irion. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  14. [Strategies to Cope with the Shortage of Technologists: Facing the Mass-Retirement of the 'Baby-Boomer' Generation].

    PubMed

    Morikane, Keita; Yamada, Miyuki

    2015-03-01

    In Japan, the primary 'baby-boomer' generation, born between 1947 and 1949, is now in its retirement. This has caused a marked shortage of human resources nationwide. Clinical laboratory technologists are no exception, and many clinical laboratories in Japanese healthcare facilities are struggling with management because the number of new graduates, i.e., newly licensed technologists, is mostly fixed and, therefore, their recruitment is becoming more and more competitive. Our laboratory is now facing a wave of mass-retirement associated with our history. In addition, in the early 2000s, there was almost no position for new graduates replacing those retiring because of the change in the social healthcare system as well as our hospital's policy. This resulted in uneven numbers of technologists in generations, and it seemed to be getting worse. Fortunately, five years ago, the direction of social health care was changed and lots of positions became available as a result. We have been trying to recruit new graduates and experienced technologists as well, and were able to hire 18 people. Among them, 8 were non-freshmen. The generation gap has been mostly resolved. We will continue to make our laboratory more attractive not just to new graduates but also to experienced technologists, especially those who wish to return to work after a several-year absence to raise their children. We believe that this will energize our laboratory.

  15. Conflict escalation in paediatric services: findings from a qualitative study.

    PubMed

    Forbat, Liz; Teuten, Bea; Barclay, Sarah

    2015-08-01

    To explore clinician and family experiences of conflict in paediatric services, in order to map the trajectory of conflict escalation. Qualitative interview study, employing extreme-case sampling. Interviews were analysed using an iterative thematic approach to identify common themes regarding the experience and escalation of conflict. Thirty-eight health professionals and eight parents. All participants had direct experience of conflict, including physical assault and court proceedings, at the interface of acute and palliative care. Two teaching hospitals, one district general hospital and two paediatric hospices in England, in 2011. Conflicts escalate in a predictable manner. Clearly identifiable behaviours by both clinicians and parents are defined as mild, moderate and severe. Mild describes features like the insensitive use of language and a history of unresolved conflict. Moderate involves a deterioration of trust, and a breakdown of communication and relationships. Severe marks disintegration of working relationships, characterised by behavioural changes including aggression, and a shift in focus from the child's best interests to the conflict itself. Though conflicts may remain at one level, those which escalated tended to move sequentially from one level to the next. Understanding how conflicts escalate provides clinicians with a practical, evidence-based framework to identify the warning signs of conflict in paediatrics. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  16. Careers in Optometry.

    ERIC Educational Resources Information Center

    Kitchell, Frank M.

    This publication, a pamphlet included in the B'nai B'rith Occupational Brief Series, directs its attention to that profession specifically licensed to care for human vision. The nature of work and the fields of specialization within the profession are described. Personal qualifications, educational and national (governmental) requirements, and…

  17. 9 CFR 2.6 - Annual license fees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... research facilities, dealers, exhibitors, retail pet stores, and persons for use as pets, directly or... animals to research facilities, dealers, exhibitors, retail pet stores, and persons for use as pets..., dealers, exhibitors, retail pet stores, and persons for use as pets, during the preceding business year...

  18. 9 CFR 2.6 - Annual license fees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... research facilities, dealers, exhibitors, retail pet stores, and persons for use as pets, directly or... animals to research facilities, dealers, exhibitors, retail pet stores, and persons for use as pets..., dealers, exhibitors, retail pet stores, and persons for use as pets, during the preceding business year...

  19. 9 CFR 2.6 - Annual license fees.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... research facilities, dealers, exhibitors, retail pet stores, and persons for use as pets, directly or... animals to research facilities, dealers, exhibitors, retail pet stores, and persons for use as pets..., dealers, exhibitors, retail pet stores, and persons for use as pets, during the preceding business year...

  20. 9 CFR 2.6 - Annual license fees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... research facilities, dealers, exhibitors, retail pet stores, and persons for use as pets, directly or... animals to research facilities, dealers, exhibitors, retail pet stores, and persons for use as pets..., dealers, exhibitors, retail pet stores, and persons for use as pets, during the preceding business year...

  1. 10 CFR 1.19 - Other committees, boards, and panels.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... of Nuclear Regulatory Research on important management matters in the direction of the Commission's... science, waste disposal and seismic and structural engineering. In performing its activities, the... information science and in managing records of the Commission's licensing process for the HLW repository. [52...

  2. 10 CFR 1.19 - Other committees, boards, and panels.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... of Nuclear Regulatory Research on important management matters in the direction of the Commission's... science, waste disposal and seismic and structural engineering. In performing its activities, the... information science and in managing records of the Commission's licensing process for the HLW repository. [52...

  3. 10 CFR 1.19 - Other committees, boards, and panels.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... of Nuclear Regulatory Research on important management matters in the direction of the Commission's... science, waste disposal and seismic and structural engineering. In performing its activities, the... information science and in managing records of the Commission's licensing process for the HLW repository. [52...

  4. 10 CFR 1.19 - Other committees, boards, and panels.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... of Nuclear Regulatory Research on important management matters in the direction of the Commission's... science, waste disposal and seismic and structural engineering. In performing its activities, the... information science and in managing records of the Commission's licensing process for the HLW repository. [52...

  5. 10 CFR 1.19 - Other committees, boards, and panels.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... of Nuclear Regulatory Research on important management matters in the direction of the Commission's... science, waste disposal and seismic and structural engineering. In performing its activities, the... information science and in managing records of the Commission's licensing process for the HLW repository. [52...

  6. Many Paths to Learning Software.

    ERIC Educational Resources Information Center

    Harp, Candice; And Others

    1997-01-01

    Respondents drawn from a sample of licensed software users rated experimenting and asking coworkers as the most useful ways to learn new software. Clerical workers preferred interaction with trainers; knowledge workers/managers relied on experience and coworkers. Dependent learners (n=49) preferred an instructor-directed approach; self-directed…

  7. 10 CFR 1.23 - Office of the General Counsel.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., providing opinions, advice, and assistance to the agency with respect to all of its activities; (b) Reviews and prepares appropriate draft Commission decisions on public petitions seeking direct Commission... and reviews draft Commission decisions on Atomic Safety and Licensing Board decisions and rulings; (c...

  8. 31 CFR 586.204 - Prohibited new investment within Serbia.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Serbia. 586.204 Section 586.204 Money and Finance: Treasury Regulations Relating to Money and Finance... (SERBIA & MONTENEGRO) KOSOVO SANCTIONS REGULATIONS Prohibitions § 586.204 Prohibited new investment within Serbia. Except as otherwise provided in regulations, orders, directives, or licenses that may hereafter...

  9. Licensing procedures and registration of medical doctors in the European Union.

    PubMed

    Kovacs, Eszter; Schmidt, Andrea E; Szocska, Gabor; Busse, Reinhard; McKee, Martin; Legido-Quigley, Helena

    2014-06-01

    The current proposals to update the European Union (EU) directive on professional qualifications will have potentially important implications for health professions. Yet those discussing it will struggle to find basic information on key issues such as licensing and registration of physicians in different countries. A survey was conducted among national experts in 14 EU member states, supplemented by literature and independent expert review. The questionnaire covered five components of licensing and registration: (1) definitions, (2) regulatory basis, (3) governance, (4) the process of registration and (5) flow and quantity of applications. We identify seven areas of concern: (1) the meaning of terminology, which is inconsistent; (2) the role of language assessments and the responsibility for them; (3) whether approval to practise should be lifelong or time limited, subject to periodic assessment; (4) the need for improved systems to identify those deemed no longer fit to practise in one member state; (5) the complexity of processes for graduates from non-EU/European Economic Area (EAA) countries; (6) public access to registers; and (7) transparency of systems of governance. The systems of licensing and registration of doctors in Europe have developed within specific national contexts and vary widely. This creates inevitable problems in the context of free movement of professionals and increasing mobility. © 2014 Royal College of Physicians.

  10. Current and anticipated use of thermal-hydraulic codes for BWR transient and accident analyses in Japan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Arai, Kenji; Ebata, Shigeo

    1997-07-01

    This paper summarizes the current and anticipated use of the thermal-hydraulic and neutronic codes for the BWR transient and accident analyses in Japan. The codes may be categorized into the licensing codes and the best estimate codes for the BWR transient and accident analyses. Most of the licensing codes have been originally developed by General Electric. Some codes have been updated based on the technical knowledge obtained in the thermal hydraulic study in Japan, and according to the BWR design changes. The best estimates codes have been used to support the licensing calculations and to obtain the phenomenological understanding ofmore » the thermal hydraulic phenomena during a BWR transient or accident. The best estimate codes can be also applied to a design study for a next generation BWR to which the current licensing model may not be directly applied. In order to rationalize the margin included in the current BWR design and develop a next generation reactor with appropriate design margin, it will be required to improve the accuracy of the thermal-hydraulic and neutronic model. In addition, regarding the current best estimate codes, the improvement in the user interface and the numerics will be needed.« less

  11. Functional Roles of Acetylated Histone Marks at Mouse Meiotic Recombination Hot Spots

    PubMed Central

    Wu, Zhen; Fallahi, Mohammad; Ouizem, Souad; Liu, Qin; Li, Weimin; Costi, Roberta; Roush, William R.; Bois, Philippe R. J.

    2016-01-01

    ABSTRACT Meiotic recombination initiates following the formation of DNA double-strand breaks (DSBs) by the Spo11 endonuclease early in prophase I, at discrete regions in the genome coined “hot spots.” In mammals, meiotic DSB site selection is directed in part by sequence-specific binding of PRDM9, a polymorphic histone H3 (H3K4Me3) methyltransferase. However, other chromatin features needed for meiotic hot spot specification are largely unknown. Here we show that the recombinogenic cores of active hot spots in mice harbor several histone H3 and H4 acetylation and methylation marks that are typical of open, active chromatin. Further, deposition of these open chromatin-associated histone marks is dynamic and is manifest at spermatogonia and/or pre-leptotene-stage cells, which facilitates PRDM9 binding and access for Spo11 to direct the formation of DSBs, which are initiated at the leptotene stage. Importantly, manipulating histone acetylase and deacetylase activities established that histone acetylation marks are necessary for both hot spot activity and crossover resolution. We conclude that there are functional roles for histone acetylation marks at mammalian meiotic recombination hot spots. PMID:27821479

  12. Mark F. Davis | NREL

    Science.gov Websites

    | 303-384-6140 Orcid ID http://orcid.org/0000-0003-4541-9852 Research Interests Dr. Mark Davis is the years, he has served as the Platform Program Manager for Thermochemical and has directed research Science Center, including high throughput recalcitrance assays, omics research, computational modeling

  13. 46 CFR 160.057-5 - Marking.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (15 Minutes) § 160.057-5 Marking. (a) Directions for use. Each floating orange smoke distress signal shall be plainly and indelibly... with the commercial designation of the signal, the words “Floating Orange Smoke Distress Signal (15...

  14. 46 CFR 160.022-5 - Marking.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (5 Minutes) § 160.022-5 Marking. (a) Directions for use. Each floating orange smoke distress signal shall be plainly and indelibly... the commercial designation of the signal, the words “Floating Orange Smoke Distress Signal”, name and...

  15. 46 CFR 160.057-5 - Marking.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (15 Minutes) § 160.057-5 Marking. (a) Directions for use. Each floating orange smoke distress signal shall be plainly and indelibly... with the commercial designation of the signal, the words “Floating Orange Smoke Distress Signal (15...

  16. 46 CFR 160.022-5 - Marking.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (5 Minutes) § 160.022-5 Marking. (a) Directions for use. Each floating orange smoke distress signal shall be plainly and indelibly... the commercial designation of the signal, the words “Floating Orange Smoke Distress Signal”, name and...

  17. 46 CFR 160.022-5 - Marking.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (5 Minutes) § 160.022-5 Marking. (a) Directions for use. Each floating orange smoke distress signal shall be plainly and indelibly... the commercial designation of the signal, the words “Floating Orange Smoke Distress Signal”, name and...

  18. 46 CFR 160.022-5 - Marking.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (5 Minutes) § 160.022-5 Marking. (a) Directions for use. Each floating orange smoke distress signal shall be plainly and indelibly... the commercial designation of the signal, the words “Floating Orange Smoke Distress Signal”, name and...

  19. 46 CFR 160.057-5 - Marking.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (15 Minutes) § 160.057-5 Marking. (a) Directions for use. Each floating orange smoke distress signal shall be plainly and indelibly... with the commercial designation of the signal, the words “Floating Orange Smoke Distress Signal (15...

  20. 46 CFR 160.022-5 - Marking.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (5 Minutes) § 160.022-5 Marking. (a) Directions for use. Each floating orange smoke distress signal shall be plainly and indelibly... the commercial designation of the signal, the words “Floating Orange Smoke Distress Signal”, name and...

  1. 46 CFR 160.057-5 - Marking.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (15 Minutes) § 160.057-5 Marking. (a) Directions for use. Each floating orange smoke distress signal shall be plainly and indelibly... with the commercial designation of the signal, the words “Floating Orange Smoke Distress Signal (15...

  2. 46 CFR 160.057-5 - Marking.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (15 Minutes) § 160.057-5 Marking. (a) Directions for use. Each floating orange smoke distress signal shall be plainly and indelibly... with the commercial designation of the signal, the words “Floating Orange Smoke Distress Signal (15...

  3. 46 CFR 162.060-22 - Marking requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... effects of normal wear and tear and exposure to water, salt spray, direct sunlight, heat, cold, and any...: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Ballast Water Management Systems § 162.060-22 Marking requirements. (a) Each ballast water management system (BWMS) manufactured under Coast Guard approval must have...

  4. 46 CFR 162.060-22 - Marking requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... effects of normal wear and tear and exposure to water, salt spray, direct sunlight, heat, cold, and any...: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Ballast Water Management Systems § 162.060-22 Marking requirements. (a) Each ballast water management system (BWMS) manufactured under Coast Guard approval must have...

  5. 46 CFR 162.060-22 - Marking requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... effects of normal wear and tear and exposure to water, salt spray, direct sunlight, heat, cold, and any...: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Ballast Water Management Systems § 162.060-22 Marking requirements. (a) Each ballast water management system (BWMS) manufactured under Coast Guard approval must have...

  6. 10 CFR 2.807 - Effective date.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Effective date. 2.807 Section 2.807 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS Rulemaking... the Commission directs otherwise on good cause found and published in the notice of rule making. ...

  7. Whether Foreign Military Sales or Direct Commercial Sales: A Case Study of the UK E-3 AWACS

    DTIC Science & Technology

    1990-09-01

    arrangements available include coproduction, licensed production, subcontractor production, overseas investment, technology transfer, and countertrade ...commercial arrangement between the U.S. manufacturer and a foreign entity. Countertrade - Purchase of goods and services from the buyer country as a

  8. 15 CFR 960.2 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... LICENSING OF PRIVATE REMOTE SENSING SYSTEMS General § 960.2 Scope. (a) The Act and the regulations in this... proposes to operate a private remote sensing space system, either directly or through an affiliate or... private remote sensing system. (b) In determining whether substantial connections exist with regard to a...

  9. 15 CFR 960.2 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... LICENSING OF PRIVATE REMOTE SENSING SYSTEMS General § 960.2 Scope. (a) The Act and the regulations in this... proposes to operate a private remote sensing space system, either directly or through an affiliate or... private remote sensing system. (b) In determining whether substantial connections exist with regard to a...

  10. 15 CFR 960.2 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... LICENSING OF PRIVATE REMOTE SENSING SYSTEMS General § 960.2 Scope. (a) The Act and the regulations in this... proposes to operate a private remote sensing space system, either directly or through an affiliate or... private remote sensing system. (b) In determining whether substantial connections exist with regard to a...

  11. 15 CFR 960.2 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... LICENSING OF PRIVATE REMOTE SENSING SYSTEMS General § 960.2 Scope. (a) The Act and the regulations in this... proposes to operate a private remote sensing space system, either directly or through an affiliate or... private remote sensing system. (b) In determining whether substantial connections exist with regard to a...

  12. 15 CFR 960.2 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... LICENSING OF PRIVATE REMOTE SENSING SYSTEMS General § 960.2 Scope. (a) The Act and the regulations in this... proposes to operate a private remote sensing space system, either directly or through an affiliate or... private remote sensing system. (b) In determining whether substantial connections exist with regard to a...

  13. 14 CFR 23.1547 - Magnetic direction indicator.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Magnetic direction indicator. 23.1547... Limitations and Information Markings and Placards § 23.1547 Magnetic direction indicator. (a) A placard meeting the requirements of this section must be installed on or near the magnetic direction indicator. (b...

  14. 14 CFR 25.1547 - Magnetic direction indicator.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Magnetic direction indicator. 25.1547... Markings and Placards § 25.1547 Magnetic direction indicator. (a) A placard meeting the requirements of this section must be installed on, or near, the magnetic direction indicator. (b) The placard must show...

  15. 14 CFR 29.1547 - Magnetic direction indicator.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Magnetic direction indicator. 29.1547... Markings and Placards § 29.1547 Magnetic direction indicator. (a) A placard meeting the requirements of this section must be installed on or near the magnetic direction indicator. (b) The placard must show...

  16. 14 CFR 25.1547 - Magnetic direction indicator.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Magnetic direction indicator. 25.1547... Markings and Placards § 25.1547 Magnetic direction indicator. (a) A placard meeting the requirements of this section must be installed on, or near, the magnetic direction indicator. (b) The placard must show...

  17. 14 CFR 29.1547 - Magnetic direction indicator.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Magnetic direction indicator. 29.1547... Markings and Placards § 29.1547 Magnetic direction indicator. (a) A placard meeting the requirements of this section must be installed on or near the magnetic direction indicator. (b) The placard must show...

  18. 14 CFR 23.1547 - Magnetic direction indicator.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Magnetic direction indicator. 23.1547... Limitations and Information Markings and Placards § 23.1547 Magnetic direction indicator. (a) A placard meeting the requirements of this section must be installed on or near the magnetic direction indicator. (b...

  19. ORC1 BAH domain links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome

    PubMed Central

    Kuo, Alex J.; Song, Jikui; Cheung, Peggie; Ishibe-Murakami, Satoko; Yamazoe, Sayumi; Chen, James K.; Patel, Dinshaw J.; Gozani, Or

    2012-01-01

    Recognition of distinctly modified histones by specialized “effector” proteins constitutes a key mechanism for transducing molecular events at chromatin to biological outcomes1. Effector proteins influence DNA-templated processes, including transcription, DNA recombination, and DNA repair; however, no effector functions have yet been identified within the mammalian machinery that regulates DNA replication. Here we show that ORC1 – a component of ORC (origin of replication complex), which mediates pre-DNA replication licensing2 – contains a BAH (bromo adjacent homology) domain that specifically recognizes histone H4 dimethylated at lysine 20 (H4K20me2). Recognition of H4K20me2 is a property common to BAH domains present within diverse metazoan ORC1 proteins. Structural studies reveal that the specificity of the BAH domain for H4K20me2 is mediated by a dynamic aromatic dimethyllysine-binding cage and multiple intermolecular contacts involving the bound peptide. H4K20me2 is enriched at replication origins and abrogating ORC1 recognition of H4K20me2 in cells impairs ORC1 occupancy at origins, ORC chromatin loading, and cell-cycle progression. Mutation of the ORC1 BAH domain has been implicated in the etiology of Meier-Gorlin syndrome (MGS)3,4, a form of primordial dwarfism5, and ORC1 depletion in zebrafish results in an MGS-like phenotype4. We find that wild-type human ORC1, but not ORC1 H4K20me2-binding mutants, rescues the growth retardation of orc1 morphants. Moreover, zebrafish depleted of H4K20me2 have diminished body size, mirroring the phenotype of orc1 morphants. Together, our results identify the BAH domain as a novel methyllysine-binding module, thereby establishing the first direct link between histone methylation and the metazoan DNA replication machinery, and defining a pivotal etiologic role for the canonical H4K20me2 mark, via ORC1, in primordial dwarfism. PMID:22398447

  20. Characteristics of On-Road Driving Performance of Persons With Central Vision Loss Who Use Bioptic Telescopes

    PubMed Central

    Wood, Joanne M.; McGwin, Gerald; Elgin, Jennifer; Searcey, Karen; Owsley, Cynthia

    2013-01-01

    Purpose. To compare the on-road driving performance of visually impaired drivers using bioptic telescopes with age-matched controls. Methods. Participants included 23 persons (mean age = 33 ± 12 years) with visual acuity of 20/63 to 20/200 who were legally licensed to drive through a state bioptic driving program, and 23 visually normal age-matched controls (mean age = 33 ± 12 years). On-road driving was assessed in an instrumented dual-brake vehicle along 14.6 miles of city, suburban, and controlled-access highways. Two backseat evaluators independently rated driving performance using a standardized scoring system. Vehicle control was assessed through vehicle instrumentation and video recordings used to evaluate head movements, lane-keeping, pedestrian detection, and frequency of bioptic telescope use. Results. Ninety-six percent (22/23) of bioptic drivers and 100% (23/23) of controls were rated as safe to drive by the evaluators. There were no group differences for pedestrian detection, or ratings for scanning, speed, gap judgments, braking, indicator use, or obeying signs/signals. Bioptic drivers received worse ratings than controls for lane position and steering steadiness and had lower rates of correct sign and traffic signal recognition. Bioptic drivers made significantly more right head movements, drove more often over the right-hand lane marking, and exhibited more sudden braking than controls. Conclusions. Drivers with central vision loss who are licensed to drive through a bioptic driving program can display proficient on-road driving skills. This raises questions regarding the validity of denying such drivers a license without the opportunity to train with a bioptic telescope and undergo on-road evaluation. PMID:23640044

  1. International Conference: Paraoxonases - Basic and Clinical Directions of Current Research (1st) Held in Ann Arbor, Michigan on April 22-24, 2004

    DTIC Science & Technology

    2005-04-01

    cholesterol lowering by simvastatin and atorvastatin Mark Roest, UMC Utrecht, Utrecht, The Netherlands Population-based and family studies suggest an...lowering by simvastatin and atorvastatin * Mark ROEST, UMC Utrecht, Utrecht, The Netherlands 20. Study of factors influencing the decreased paraoxonase...lowering by simvastatin and atorvastatin . Mark Roest1 , Thomas van Himbergen1, 2, Jacqueline de Graaf 2, Hiroaki Hattori 3, John Kastelein4

  2. The Acquisition of Evidentiality and Source Monitoring

    ERIC Educational Resources Information Center

    Ozturk, Ozge; Papafragou, Anna

    2016-01-01

    Evidentiality in language marks how information contained in a sentence was acquired. For instance, Turkish has two past-tense morphemes that mark whether access to information was direct (typically, perception) or indirect (hearsay/inference). Full acquisition of evidential systems appears to be a late achievement cross-linguistically. Currently,…

  3. Dispersal of the spruce beetle, Dendroctonus rufipennis, and the engraver beetle, Ips perturbatus, in Alaska.

    Treesearch

    Richard A. Werner; Edward H. Holsten

    1997-01-01

    Mark-release-recapture experiments were performed with spruce beetles (Dendroctonus rufipennis (Kirby)) and Ips engraver beetles (Ips perturbatus (Eichhoff)) to determine distance and direction of dispersal. The recapture rate of beetles marked with fluorescent powder was extremely low. Most I. perturbatus...

  4. The Processing of Case in Near-Native Spanish

    ERIC Educational Resources Information Center

    Jegerski, Jill

    2015-01-01

    This article reports a study that sought to determine whether non-native sentence comprehension can show sensitivity to two different types of Spanish case marking. Sensitivity to case violations was generally more robust with indirect objects in ditransitive constructions than with differential object marking of animate direct objects, even among…

  5. Research of aerohydrodynamic and aeroelastic processes on PNRPU HPC system

    NASA Astrophysics Data System (ADS)

    Modorskii, V. Ya.; Shevelev, N. A.

    2016-10-01

    Research of aerohydrodynamic and aeroelastic processes with the High Performance Computing Complex in PNIPU is actively conducted within the university priority development direction "Aviation engine and gas turbine technology". Work is carried out in two areas: development and use of domestic software and use of well-known foreign licensed applied software packets. In addition, the third direction associated with the verification of computational experiments - physical modeling, with unique proprietary experimental installations is being developed.

  6. Frequency of and responses to illegal activity related to commerce in firearms: findings from the Firearms Licensee Survey.

    PubMed

    Wintemute, Garen J

    2013-12-01

    Firearms may be obtained illegally from federally-licensed dealers and pawnbrokers through surrogate (straw) purchases, undocumented purchases and theft. Some retailers knowingly make illegal sales. To obtain information about the frequency of and risk factors for these events, and retailers' reactions to them, directly from licensed retailers. Survey of a random sample of 1601 licensed dealers and pawnbrokers in 43 states who were believed to sell ≥50 firearms annually, conducted by mail during June-August 2011. The response rate was 36.9%, typical of establishment surveys using such methods. In the preceding year, 67.3% of respondents experienced attempted straw purchases; 42.4% experienced undocumented purchase attempts. For each event, 10% reported ≥1 occurrence/month. A quarter (25.6%) experienced firearm theft in the preceding 5 years. Pawnbroker status, sales volume, denied sales and sales of firearms that were subsequently traced by law enforcement were associated with all outcomes in multivariate analysis. Estimates of retailer involvement in illegal sales (median 3%, IQR 1-10%) were related in multivariate analysis to respondents' age and sex, and to denied sales. In a hypothetical case involving 50 illegal sales, respondents recommended prolonged incarceration (median 10 years, IQR 5-20 years) and a substantial fine (median $50 000, IQR $10 000-$250 000) for retailers and made similar recommendations for buyers. Attempts to acquire firearms illegally from licensed dealers and pawnbrokers are common. Characteristics associated with frequency of occurrence may facilitate prevention efforts. Licensed retailers consider selling and buying firearms illegally to be serious crimes.

  7. 76 FR 9613 - USEC Inc. (American Centrifuge Lead Cascade Facility and American Centrifuge Plant); Order...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... NUCLEAR REGULATORY COMMISSION [EA-11-013] USEC Inc. (American Centrifuge Lead Cascade Facility and American Centrifuge Plant); Order Approving Direct Transfer of Licenses and Conforming Amendment I USEC... Centrifuge Lead Cascade Facility (Lead Cascade) and American Centrifuge Plant (ACP), respectively, which...

  8. University Technology Transfer: In Tough Economic Times

    ERIC Educational Resources Information Center

    Powers, Joshua B.; Campbell, Eric G.

    2009-01-01

    In 1907, Frederick Cottrell, professor of chemistry at the University of California-Berkeley and father of the modern academic patent, worried that if universities became too directly involved in patenting and licensing operations, their thirst for profits could lead to the erosion of the openness necessary for academic science to flourish. For…

  9. 10 CFR 73.55 - Requirements for physical protection of licensed activities in nuclear power reactors against...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... integration of systems, technologies, programs, equipment, supporting processes, and implementing procedures...-in-depth methodologies to minimize the potential for an insider to adversely affect, either directly... protection of digital computer and communication systems and networks. (ii) Site-specific conditions that...

  10. 47 CFR 25.158 - Consideration of GSO-like satellite applications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... directional antennas. Examples of GSO-like satellite systems are those which use earth stations with antennas... contiguous bandwidth in both the uplink and downlink band. Each licensee's bandwidth selection shall not... selection. (e) Services offered pursuant to a GSO-like license in a frequency band granted before the...

  11. 47 CFR 25.157 - Consideration of NGSO-like satellite applications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-directional antennas. (b) Each NGSO-like satellite system application will be reviewed to determine whether it... licensee's bandwidth selection in both the uplink and downlink band shall not preclude other licensees from... to make another selection. (g)(1) In the event that an applicants' license is cancelled for any...

  12. Recent Developments in Cultural Heritage Image Databases: Directions for User-Centered Design.

    ERIC Educational Resources Information Center

    Stephenson, Christie

    1999-01-01

    Examines the Museum Educational Site Licensing (MESL) Project--a cooperative project between seven cultural heritage repositories and seven universities--as well as other developments of cultural heritage image databases for academic use. Reviews recent literature on image indexing and retrieval, interface design, and tool development, urging a…

  13. Citizen Participation in Broadcast Licensing Before the FCC.

    ERIC Educational Resources Information Center

    Grundfest, Joseph A.

    This report examines the public's role in determining the dimensions of the public interest in the regulation of broadcast services. Chapter II describes some of the avenues open to citizens to influence the Federal Communication Commission, including: (1) direct contact between broadcasters and citizens, (2) citizen participation in the…

  14. 12 CFR 235.7 - Limitations on payment card restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Section 235.7 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL... restrictions. (a) Prohibition on network exclusivity—(1) In general. An issuer or payment card network shall not directly or through any agent, processor, or licensed member of a payment card network, by...

  15. 12 CFR 235.7 - Limitations on payment card restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Section 235.7 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL... restrictions. (a) Prohibition on network exclusivity—(1) In general. An issuer or payment card network shall not directly or through any agent, processor, or licensed member of a payment card network, by...

  16. 12 CFR 235.7 - Limitations on payment card restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Section 235.7 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL... restrictions. (a) Prohibition on network exclusivity—(1) In general. An issuer or payment card network shall not directly or through any agent, processor, or licensed member of a payment card network, by...

  17. 77 FR 44700 - Saratoga Investment Corp., et al.; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... lesser extent equity. The Investment Adviser, a Delaware limited liability company, is the investment..., a Delaware limited partnership, is a small business investment company (``SBIC'') licensed by the... Act. The Company directly owns 99% of Saratoga SBIC in the form of a limited partnership interest and...

  18. 75 FR 75179 - Government-Owned Inventions; Availability for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-02

    ... of Federally-funded research and development. Foreign patent applications are filed on selected... and Its Reactivity to Human Tumors,'' HHS Reference No. E-272-2010/0-- Research Material. Patent... before they can act to kill the cell. As a result, research has generally been directed to overcoming MDR...

  19. 76 FR 11764 - Notice of Availability of Government-Owned Inventions; Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    .... Patent No. 7,048,854: Apparatus for the removal of heavy metals from acidic wastewater and chemical... inventions cited should be directed to Andrew Drucker, Naval Facilities Engineering Service Center, Code EV12... INFORMATION CONTACT: Andrew Drucker supporting the Head of Technology Transfer Office, Naval Facilities...

  20. 77 FR 69866 - Government-Owned Inventions; Availability for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... for Diabetes and Obesity Description of Technology: This invention is directed to adeno- associated virus (AAV) vector delivery of exendin-4 (Ex-4) to salivary glands as treatment for diabetes and obesity... and weight profile in two rat models of obesity and type 2 diabetes. Further, AAV-mediated delivery of...

  1. "Seeing" the Difference: The Importance of Visibility and Action as a Mark of "Authenticity" in Co-production Comment on "Collaboration and Co-production of Knowledge in Healthcare: Opportunities and Challenges".

    PubMed

    Cooke, Jo; Langley, Joe; Wolstenholme, Dan; Hampshaw, Susan

    2016-10-17

    The Rycroft-Malone paper states that co-production relies on 'authentic' collaboration as a context for action. Our commentary supports and extends this assertion. We suggest that 'authentic' co-production involves processes where participants can 'see' the difference that they have made within the project and beyond. We provide examples including: the use of design in health projects which seek to address power issues and make contributions visible through iteration and prototyping; and the development of 'actionable outputs' from research that are the physical embodiment of co-production. Finally, we highlight the elements of the Collaboration for Leadership in Applied Health Research and Care (CLAHRC) architecture that enables the inclusion of such collaborative techniques that demonstrate visible co-production. We reinforce the notion that maintaining collaboration requires time, flexible resources, blurring of knowledge producer-user boundaries, and leaders who promote epistemological tolerance and methodological exploration. © 2017 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

  2. Values, trust and science - building trust in today's food system in an era of radical transparency.

    PubMed

    Arnot, Charlie; Vizzier-Thaxton, Yvonne; Scanes, Colin G

    2016-07-21

    Public concern exists globally about the food system and both the practices and the intensification of animal agriculture. Examples are presented of public opinion in North America, the European Union, and the People's Republic of China. Negative perceptions increase with distance from production agriculture. Even animal science faculty members do not uniformly support present production practices. Public trust in the food system is based on consumers' or public confidence (shared values based on corporate and institutional social responsibility or their fiduciary responsibility), competence of the people or groups providing the information and the influence of others (e.g., friends and family). Producer or company discussion of issues has focused on competency and "the science" when confidence is markedly more important to consumers and more effective. It is argued that the food system largely escapes regulation by federal and state governments by a social license based on public confidence. However, a tipping point(s) exists such that a crisis could greatly diminish public confidence and end the social license and bring with it increases in regulation. Advocacy for production agriculture (poultry and livestock) needs to incorporate recognition of the need to reaffirm the public's trust, assuring shared values together with an emphasis on good science. © 2016 Poultry Science Association Inc.

  3. Artillery ammunition marking tests

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Weil, B.S.; Lewis, J.C.

    1995-04-01

    This report describes the testing results of two approaches being considered for marking ink artillery ammunition with machine-readable data symbols. The first approach used ink-jet printing directly onto projectiles, and the second approach employed thermal-transfer printing onto self-adhesive labels that are subsequently applied automatically to projectiles. The objectives of this evaluation for each marking technology were to (1) determine typical system performance characteristics using the best commercially available equipment and (2) identify any special requirements necessary for handling ammunition when these technologies are employed.

  4. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Klise, Katherine A.; Siirola, John Daniel; Hart, David

    The Water Security Toolkit (WST) is a suite of open source software tools that can be used by water utilities to create response strategies to reduce the impact of contamination in a water distribution network . WST includes hydraulic and water quality modeling software , optimizati on methodologies , and visualization tools to identify: (1) sensor locations to detect contamination, (2) locations in the network in which the contamination was introduced, (3) hydrants to remove contaminated water from the distribution system, (4) locations in the network to inject decontamination agents to inactivate, remove, or destroy contaminants, (5) locations in themore » network to take grab sample s to help identify the source of contamination and (6) valves to close in order to isolate contaminate d areas of the network. This user manual describes the different components of WST , along w ith examples and case studies. License Notice The Water Security Toolkit (WST) v.1.2 Copyright c 2012 Sandia Corporation. Under the terms of Contract DE-AC04-94AL85000, there is a non-exclusive license for use of this work by or on behalf of the U.S. government. This software is distributed under the Revised BSD License (see below). In addition, WST leverages a variety of third-party software packages, which have separate licensing policies: Acro Revised BSD License argparse Python Software Foundation License Boost Boost Software License Coopr Revised BSD License Coverage BSD License Distribute Python Software Foundation License / Zope Public License EPANET Public Domain EPANET-ERD Revised BSD License EPANET-MSX GNU Lesser General Public License (LGPL) v.3 gcovr Revised BSD License GRASP AT&T Commercial License for noncommercial use; includes randomsample and sideconstraints executable files LZMA SDK Public Domain nose GNU Lesser General Public License (LGPL) v.2.1 ordereddict MIT License pip MIT License PLY BSD License PyEPANET Revised BSD License Pyro MIT License PyUtilib Revised BSD License PyYAML MIT License runpy2 Python Software Foundation License setuptools Python Software Foundation License / Zope Public License six MIT License TinyXML zlib License unittest2 BSD License Utilib Revised BSD License virtualenv MIT License Vol Common Public License vpykit Revised BSD License Additionally, some precompiled WST binary distributions might bundle other third-party executables files: Coliny Revised BSD License (part of Acro project) Dakota GNU Lesser General Public License (LGPL) v.2.1 PICO Revised BSD License (part of Acro project) i Revised BSD License Redistribution and use in source and binary forms, with or without modification, are permitted provided that the following conditions are met: * Redistributions of source code must retain the above copyright notice, this list of conditions and the following disclaimer. * Redistributions in binary form must reproduce the above copyright notice, this list of conditions and the following disclaimer in the documentation and/or other materials provided with the distribution. * Neither the name of Sandia National Laboratories nor Sandia Corporation nor the names of its con- tributors may be used to endorse or promote products derived from this software without specific prior written permission. THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IM- PLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL SANDIA CORPORATION BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUD- ING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. ii Acknowledgements This work was supported by the U.S. Environmental Protection Agency through its Office of Research and Development (Interagency Agreement # DW8992192801). The material in this document has been subject to technical and policy review by the U.S. EPA, and approved for publication. The views expressed by individual authors, however, are their own, and do not necessarily reflect those of the U.S. Environmental Protection Agency. Mention of trade names, products, or services does not convey official U.S. EPA approval, endorsement, or recommendation. The Water Security Toolkit is an extension of the Threat Ensemble Vulnerability Assessment-Sensor Place- ment Optimization Tool (TEVA-SPOT), which was also developed with funding from the U.S. Environ- mental Protection Agency through its Office of Research and Development (Interagency Agreement # DW8992192801). The authors acknowledge the following individuals for their contributions to the devel- opment of TEVA-SPOT: Jonathan Berry (Sandia National Laboratories), Erik Boman (Sandia National Laboratories), Lee Ann Riesen (Sandia National Laboratories), James Uber (University of Cincinnati), and Jean-Paul Watson (Sandia National Laboratories). iii Acronyms ATUS American Time-Use Survey BLAS Basic linear algebra sub-routines CFU Colony-forming unit CVAR Conditional value at risk CWS Contamination warning system EA Evolutionary algorithm EDS Event detection system EPA U.S. Environmental Protection Agency EC Extent of Contamination ERD EPANET results database file GLPK GNU Linear Programming Kit GRASP Greedy randomized adaptive sampling process HEX Hexadecimal HTML HyperText markup language INP EPANET input file LP Linear program MC Mass consumed MILP Mixed integer linear program MIP Mixed integer program MSX Multi-species extension for EPANET NFD Number of failed detections NS Number of sensors NZD Non-zero demand PD Population dosed PE Population exposed PK Population killed TAI Threat assessment input file TCE Tailed-conditioned expectation TD Time to detection TEC Timed extent of contamination TEVA Threat ensemble vulnerability assessment TSB Tryptic soy broth TSG Threat scenario generation file TSI Threat simulation input file VAR Value at risk VC Volume consumed WST Water Security Toolkit YML YAML configuration file format for WST iv Symbols Notation Definition Example { , } set brackets { 1,2,3 } means a set containing the values 1,2, and 3. [?] is an element of s [?] S means that s is an element of the set S . [?] for all s = 1 [?] s [?] S means that the statement s = 1 is true for all s in set S . P summation P n i =1 s i means s 1 + s 2 + * * * + s n . \\ set minus S \\ T means the set that contains all those elements of S that are not in set T . %7C given %7C is used to define conditional probability. P ( s %7C t ) means the prob- ability of s occurring given that t occurs. %7C ... %7C cardinality Cardinality of a set is the number of elements of the set. If set S = { 2,4,6 } , then %7C S %7C = 3. v« less

  5. Feasibility of laser marking in Barrett's esophagus with volumetric laser endomicroscopy: first-in-man pilot study.

    PubMed

    Swager, Anne-Fré; de Groof, Albert J; Meijer, Sybren L; Weusten, Bas L; Curvers, Wouter L; Bergman, Jacques J

    2017-09-01

    Volumetric laser endomicroscopy (VLE) provides a circumferential scan of the esophageal wall layers and has potential to improve detection of neoplasia in Barrett's esophagus (BE). The novel VLE laser marking system enables direct in vivo marking of suspicious areas as identified on VLE. These laser marked areas can subsequently be targeted for biopsies. The aim was to evaluate the visibility and positional accuracy of laser marks (LMs) in different esophageal tissue types on white light endoscopy (WLE) and VLE. Patients with BE with or without neoplasia underwent imaging with VLE. Protocol refinements were practiced in a learning phase. In the second phase, visibility of LMs was assessed by random marking in squamous, BE, and gastric tissue. In phase 3, positional accuracy of the LMs was tested by identifying and laser marking surrogate targets (endoscopically placed cautery marks). In the final phase, the most suspicious areas for neoplasia were identified in each patient using VLE, targeted by LMs, and biopsy samples subsequently obtained. Sixteen patients with BE were included (14 men; median age, 68 years), 1 of whom was included twice in different study phases. Worst histologic diagnoses were 9 non-dysplastic Barrett's esophagus (NDBE), 3 low-grade dysplasia (LGD), 4 high-grade dysplasia (HGD), and 1 early adenocarcinoma (EAC). In total, 222 LMs were placed, of which 97% was visible on WLE. All LMs were visible on VLE directly after marking, and 86% could be confirmed during post hoc analysis. LM targeting was successful with positional accuracy in 85% of cautery marks. Inaccurate targeting was caused by system errors or difficult cautery mark visualization on VLE. In the final phase (5 patients), 18 areas suspicious on VLE were identified, which were all successfully targeted by LMs (3 EAC, 3 HGD, 1 LGD, and 11 NDBE). Mean VLE procedure time was 22 minutes (±6 minutes standard deviation); mean endoscopy time was 56 minutes (±17 minutes). No adverse events were reported. This first-in-human study of VLE-guided laser marking was found to be feasible and safe in 17 procedures. Most LMs were visible on WLE and VLE. Targeting VLE areas of interest proved to be highly successful. VLE-guided laser marking may improve the detection and delineation of Barrett's neoplasia in the future. Copyright © 2017 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

  6. 29. WEST CONFEDERATE AVENUE, OBSERVATION TOWER, IRON BENCH AND DIRECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. WEST CONFEDERATE AVENUE, OBSERVATION TOWER, IRON BENCH AND DIRECTION FINDER, VIEW ACROSS AGRICULTURAL LANDSCAPE TOWARDS THE "HIGHWATER MARK." VIEW NE. - Gettysburg National Military Park Tour Roads, Gettysburg, Adams County, PA

  7. Farewell TID-14844; hello SECY-92-127

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lahti, G.P.; Johnson, W.J.

    This year, 1992, marks the 50th anniversary of the first sustained nuclear reaction in the pile at the University of Chicago's Stagg Field. But it also marks the 30th anniversary of the publication of TID-14844, which has served as the design-basis source term for radiological assessments supporting the licensing of nuclear power plants in the United States since its inception. The conservative TID-14844 model assumes that 100% of the noble gases and 50% of the iodines are instantaneously released to the containment and are available for leakage to the environment. TID-14844 is formally embodied in the US Nuclear Regulatory Commission'smore » (NRC's) regulations in parts 10CFR100 (siting) and 10CFR50 (review of control room habitability, postaccident shielding and sampling systems). It is also embodied in a host of NRC Regulatory Guides and NUREG reports that address off-site consequences of releases of radioactivity, equipment qualification, and other postaccident radiological concerns. On April 20, 1992, the NRC staff presented to the NRC commissioners the draft Revised Accident Source Terms for Light-Water Nuclear Power Plants.' This effort is documented in SECY-92-127 and provides the first official position of the NRC in this matter.« less

  8. 27 CFR 9.124 - Wild Horse Valley.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... direction approximately .9 mile to the summit of an unnamed hill having a marked elevation of 1,804 feet; (3... 1,824 feet; (4) Then south-southeasterly approximately .6 mile to the summit of an unnamed hill having a marked elevation of 1,866 feet; (5) Then south-southeasterly approximately .5 mile to the summit...

  9. 27 CFR 9.124 - Wild Horse Valley.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... direction approximately .9 mile to the summit of an unnamed hill having a marked elevation of 1,804 feet; (3... 1,824 feet; (4) Then south-southeasterly approximately .6 mile to the summit of an unnamed hill having a marked elevation of 1,866 feet; (5) Then south-southeasterly approximately .5 mile to the summit...

  10. 27 CFR 9.124 - Wild Horse Valley.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... direction approximately .9 mile to the summit of an unnamed hill having a marked elevation of 1,804 feet; (3... 1,824 feet; (4) Then south-southeasterly approximately .6 mile to the summit of an unnamed hill having a marked elevation of 1,866 feet; (5) Then south-southeasterly approximately .5 mile to the summit...

  11. Perioperative ultrasound-guided wire marking of calcific deposits in calcifying tendinitis of the rotator cuff.

    PubMed

    Sigg, Andreas; Draws, Detlev; Stamm, Axel; Pfeiffer, Michael

    2011-03-01

    The identification of a calcific deposit in the rotator cuff can often cause difficulties. A new technique is described to identify the calcific deposit perioperatively with a ultrasound-guided wire. The technique allows a safe direct marking of calcific deposits making the procedure faster especially in difficult cases.

  12. Direct and indirect cardiovascular actions of cathinone and MDMA in the anaesthetized rat.

    PubMed

    Alsufyani, Hadeel A; Docherty, James R

    2015-07-05

    The stimulants cathinone (from Khat leaves) and methylenedioxymeth-amphetamine (MDMA) produce adrenoceptor mediated tachycardia and vasopressor actions that may be the result of direct receptor stimulation, actions on the noradrenaline transporter, and/or displacement of noradrenaline from nerve terminals. Effects of cathinone or MDMA were compared with those of the indirect sympathomimetic tyramine. Male Wistar rats were anaesthetized with pentobarbitone for blood pressure and heart rate recording. Some rats were sympathectomised by treatment with 6-hydroxydopamine. In the anaesthetised rat, cathinone, MDMA and tyramine (all 0.001-1 mg/kg) produced marked tachycardia, tyramine produced marked pressor responses and MDMA produced small pressor responses. The tachycardia to cathinone and MDMA was almost abolished by propranolol (1mg/kg). Pretreatment with cocaine (1mg/kg) did not significantly affect the tachycardia to cathinone or MDMA, but reduced the response to tyramine. However, in sympathectomised rats, the tachycardia to cathinone or MDMA was markedly attenuated, but the tachycardia to tyramine was only partially reduced. Blood pressure effects of tyramine and MDMA were also markedly attenuated by sympathectomy. The results demonstrate firstly that cocaine may not be the most suitable agent for assessing direct versus indirect agonism in cardiovascular studies. Secondly, the use of chemical sympathectomy achieved the desired goal of demonstrating that cardiac β-adrenoceptor mediated actions of cathinone and MDMA are probably largely indirect. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. Virtual tool mark generation for efficient striation analysis in forensic science

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ekstrand, Laura

    In 2009, a National Academy of Sciences report called for investigation into the scienti c basis behind tool mark comparisons (National Academy of Sciences, 2009). Answering this call, Chumbley et al. (2010) attempted to prove or disprove the hypothesis that tool marks are unique to a single tool. They developed a statistical algorithm that could, in most cases, discern matching and non-matching tool marks made at di erent angles by sequentially numbered screwdriver tips. Moreover, in the cases where the algorithm misinterpreted a pair of marks, an experienced forensics examiner could discern the correct outcome. While this research served tomore » con rm the basic assumptions behind tool mark analysis, it also suggested that statistical analysis software could help to reduce the examiner's workload. This led to a new tool mark analysis approach, introduced in this thesis, that relies on 3D scans of screwdriver tip and marked plate surfaces at the micrometer scale from an optical microscope. These scans are carefully cleaned to remove noise from the data acquisition process and assigned a coordinate system that mathematically de nes angles and twists in a natural way. The marking process is then simulated by using a 3D graphics software package to impart rotations to the tip and take the projection of the tip's geometry in the direction of tool travel. The edge of this projection, retrieved from the 3D graphics software, becomes a virtual tool mark. Using this method, virtual marks are made at increments of 5 and compared to a scan of the evidence mark. The previously developed statistical package from Chumbley et al. (2010) performs the comparison, comparing the similarity of the geometry of both marks to the similarity that would occur due to random chance. The resulting statistical measure of the likelihood of the match informs the examiner of the angle of the best matching virtual mark, allowing the examiner to focus his/her mark analysis on a smaller range of angles. Preliminary results are quite promising. In a study with both sides of 6 screwdriver tips and 34 corresponding marks, the method distinguished known matches from known non-matches with zero false positive matches and only two matches mistaken for non-matches. For matches, it could predict the correct marking angle within 5-10 . Moreover, on a standard desktop computer, the virtual marking software is capable of cleaning 3D tip and plate scans in minutes and producing a virtual mark and comparing it to a real mark in seconds. These results support several of the professional conclusions of the tool mark analysis com- munity, including the idea that marks produced by the same tool only match if they are made at similar angles. The method also displays the potential to automate part of the comparison process, freeing the examiner to focus on other tasks, which is important in busy, backlogged crime labs. Finally, the method o ers the unique chance to directly link an evidence mark to the tool that produced it while reducing potential damage to the evidence.« less

  14. Reversal of Direct Oral Anticoagulants: Current Status and Future Directions.

    PubMed

    Weitz, Jeffrey I

    2017-02-01

    Direct oral anticoagulants (DOACs) are increasingly used for prevention and treatment of venous thromboembolism and for prevention of stroke in patients with nonvalvular atrial fibrillation. In phase III clinical trials that included more than 100,000 patients, the DOACs were at least as effective as vitamin K antagonists (VKAs) and were associated with less serious bleeding, particularly less intracranial bleeding. Real-world evidence supports these outcomes. Despite this, some physicians and patients are concerned about serious bleeding or emergencies unless specific reversal agents for the DOACs are available. However, in clinical trials performed without reversal agents, the outcome of major bleeds was similar or better in patients receiving DOACs than in those taking VKAs. Because of their short half-lives, supportive measures are sufficient to manage most bleeds in patients receiving DOACs. Anticoagulant reversal should only be considered with life-threatening bleeds, with bleeds that fail to respond to usual measures and in patients requiring urgent surgery. Idarucizumab is licensed for dabigatran reversal and andexanet alfa is likely to be soon licensed for reversal of rivaroxaban, apixaban, and edoxaban. To ensure responsible use of these agents, every hospital needs a bleeding management algorithm that identifies patients eligible for reversal and outlines appropriate dosing regimens. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  15. Tracking Snowballs

    NASA Image and Video Library

    2010-11-18

    Icy particles in the cloud around Hartley 2, as seen by NASA EPOXI mission spacecraft. A star moving through the background is marked with red and moves in a particular direction, with a particular speed; icy particles move in random directions.

  16. Direct seeding of shortleaf pine

    Treesearch

    Corinne S. Mann; David Gwaze

    2007-01-01

    Direct seeding is a potentially viable method for regenerating shortleaf pine, but it has not been used extensively. In Missouri, an estimated 10,000 acres have been direct-seeded with shortleaf pine; half of which are at Mark Twain National Forest. Direct seeding offers a flexible and efficient alternative to planting as a way to restore shortleaf pine in the Ozarks....

  17. 75 FR 17402 - South Carolina Public Service Authority; Notice of Applications for Amendment of License and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-06

    ... ``Residential Marginal'' to ``Public Vacation Recreation'' to allow expansion of a commercial lease area; Dingle... from ``Forest Management'' to ``Public Vacation Recreation'' to allow the expansion of Black's Fish... agencies directly from the Applicant. If an agency does not file comments within the time specified for...

  18. 42 CFR 438.354 - Qualifications of external quality review organizations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... as “independent”— (1) A State agency, department, university, or other State entity may not have Medicaid purchasing or managed care licensing authority; and (2) A State agency, department, university, or... known future, direct or indirect financial relationship with an MCO or PIHP that it will review as an...

  19. 42 CFR 438.354 - Qualifications of external quality review organizations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... as “independent”— (1) A State agency, department, university, or other State entity may not have Medicaid purchasing or managed care licensing authority; and (2) A State agency, department, university, or... known future, direct or indirect financial relationship with an MCO or PIHP that it will review as an...

  20. 42 CFR 438.354 - Qualifications of external quality review organizations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... as “independent”— (1) A State agency, department, university, or other State entity may not have Medicaid purchasing or managed care licensing authority; and (2) A State agency, department, university, or... known future, direct or indirect financial relationship with an MCO or PIHP that it will review as an...

  1. 42 CFR 438.354 - Qualifications of external quality review organizations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... as “independent”— (1) A State agency, department, university, or other State entity may not have Medicaid purchasing or managed care licensing authority; and (2) A State agency, department, university, or... known future, direct or indirect financial relationship with an MCO or PIHP that it will review as an...

  2. A License to Lead? A New Leadership Agenda for America's Schools.

    ERIC Educational Resources Information Center

    Hess, Frederick M.

    While considerable attention is paid to training and development for teachers, not enough is paid to the training of educational leaders, this paper contends. The aim of this paper is to provide an analytical groundwork and comprehensive direction for reform of educational leadership training to help policymakers design specific solutions to…

  3. 50 CFR 679.82 - Rockfish Program use caps and sideboard limits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... not participate in directed fishing for arrowtooth flounder, deep-water flatfish, and rex sole in the GOA (or in waters adjacent to the GOA when arrowtooth flounder, deep-water flatfish, and rex sole... authority of all eligible LLP licenses in the catcher/processor sector. (ii) For the deep-water halibut PSC...

  4. 50 CFR 679.82 - Rockfish Program use caps and sideboard limits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... not participate in directed fishing for arrowtooth flounder, deep-water flatfish, and rex sole in the GOA (or in waters adjacent to the GOA when arrowtooth flounder, deep-water flatfish, and rex sole... authority of all eligible LLP licenses in the catcher/processor sector. (ii) For the deep-water halibut PSC...

  5. Summary Statistics of Public TV Licensees, 1972.

    ERIC Educational Resources Information Center

    Lee, S. Young; Pedone, Ronald J.

    Statistics in the areas of finance, employment, broadcast and production for public TV licenses in 1972 are given in this report. Tables in the area of finance are presented specifying total funds, income, direct operating costs, and capital expenditures. Employment is divided into all employment with subdivisions for full- and part-time employees…

  6. Financing Washington's Schools in the New Millennium: Sorting through the Mixed Messages.

    ERIC Educational Resources Information Center

    Plecki, Margaret L.

    Washington State faces the challenge of balancing a number of conflicting economic and political conditions that impact K-12 education either directly or indirectly. These include reduced vehicle license fees, an existing statewide spending limit, a state revenue surplus, proposals to provide property-tax relief, proposed voter initiatives to…

  7. 24 CFR 1710.116 - Additional information.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Must an alien obtain a permit or license to own land, build a home, live, work or do business in the... divided and billed? How are voting rights in any Association apportioned? Are there management fees? If so... not directly or indirectly discriminating on the basis of race, religion, sex or national origin in...

  8. 12 CFR 145.91 - Home office.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Home office. 145.91 Section 145.91 Banks and... § 145.91 Home office. (a) All operations of a Federal savings association (“you”) are subject to direction from the home office. (b) You must notify the appropriate OCC licensing office if the permanent...

  9. 12 CFR 145.91 - Home office.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Home office. 145.91 Section 145.91 Banks and... § 145.91 Home office. (a) All operations of a Federal savings association (“you”) are subject to direction from the home office. (b) You must notify the appropriate OCC licensing office if the permanent...

  10. 12 CFR 145.91 - Home office.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Home office. 145.91 Section 145.91 Banks and... § 145.91 Home office. (a) All operations of a Federal savings association (“you”) are subject to direction from the home office. (b) You must notify the appropriate OCC licensing office if the permanent...

  11. 77 FR 43601 - Government-Owned Inventions; Availability for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-25

    ... of the patent applications. Novel Analogues of the Asthma Drug Fenoterol as Liver and Brain Cancer... as MNF, that inhibit the growth of various types of cancers, including brain, liver, colon, and lung..., represents one of the first potential drugs directed at this target. MNF crosses the blood brain barrier and...

  12. 77 FR 71593 - Robert Bosch GmbH; Analysis of Agreement Containing Consent Orders To Aid Public Comment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-03

    ... state identification number or foreign country equivalent, passport number, financial account number, or... for licensing certain patents which may be used in the implementation of two industry standards... elimination of the direct competition between Robinair and Bosch would allow the combined entity to exercise...

  13. Beginning the 21st century with advanced Automatic Parts Identification (API)

    NASA Technical Reports Server (NTRS)

    Schramm, Fred; Roxby, Don

    1994-01-01

    Under the direction of the NASA George C. Marshall Space Flight Center, Huntsville, Alabama, the development and commercialization of an advanced Automated Parts Indentification (API) system is being undertaken by Rockwell International Corporation. The new API system is based on a variable sized, machine-readable, two-dimensioanl matrix symbol that can be applied directly onto most metallic and nonmetallic materials using safe, permanent marking methods. Its checkerboard-like structure is the most space efficient of all symbologies. This high data-density symbology can be applied to products of different material sizes and geometries using application-dependent, computer-driven marking devices. The high fidelity markings produced by these devices can then be captured using a specially designed camera linked to any IBM-compatible computer. Applications of compressed symbology technology will reduce costs and improve quality, productivity, and processes in a wide variety of federal and commercial applications.

  14. Marking airdromes

    NASA Technical Reports Server (NTRS)

    James, P

    1922-01-01

    Necessity of adopting for all aviation fields, civil or military, a single system of markers for giving the direction for starting and landing (with an automatic indicator of the direction of the wind) and of indicating the good part of the field.

  15. 76 FR 62658 - Airworthiness Directives; Fokker Services B.V. Model F.27 Mark 050 and F.28 Mark 0070 and 0100...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    ...., Monday through Friday, except Federal holidays. For service information identified in this proposed AD... Operations office between 9 a.m. and 5 p.m., Monday through Friday, except Federal holidays. The AD docket..., 20105, 20121 through 20123 inclusive, 20130 through 20135 inclusive, 20141 through 20145 inclusive...

  16. Back to Basics: Incomplete Knowledge of Differential Object Marking in Spanish Heritage Speakers

    ERIC Educational Resources Information Center

    Montrul, Silvina; Bowles, Melissa

    2009-01-01

    The obligatory use of the preposition a with animate, specific direct objects in Spanish ("Juan conoce a Maria" "Juan knows Maria") is a well-known instance of Differential Object Marking (DOM; Torrego, 1998; Leonetti, 2004). Recent studies have documented the loss and/or incomplete acquisition of several grammatical features in Spanish heritage…

  17. PAS kinase is activated by direct SNF1-dependent phosphorylation and mediates inhibition of TORC1 through the phosphorylation and activation of Pbp1.

    PubMed

    DeMille, Desiree; Badal, Bryan D; Evans, J Brady; Mathis, Andrew D; Anderson, Joseph F; Grose, Julianne H

    2015-02-01

    We describe the interplay between three sensory protein kinases in yeast: AMP-regulated kinase (AMPK, or SNF1 in yeast), PAS kinase 1 (Psk1 in yeast), and the target of rapamycin complex 1 (TORC1). This signaling cascade occurs through the SNF1-dependent phosphorylation and activation of Psk1, which phosphorylates and activates poly(A)- binding protein binding protein 1 (Pbp1), which then inhibits TORC1 through sequestration at stress granules. The SNF1-dependent phosphorylation of Psk1 appears to be direct, in that Snf1 is necessary and sufficient for Psk1 activation by alternate carbon sources, is required for altered Psk1 protein mobility, is able to phosphorylate Psk1 in vitro, and binds Psk1 via its substrate-targeting subunit Gal83. Evidence for the direct phosphorylation and activation of Pbp1 by Psk1 is also provided by in vitro and in vivo kinase assays, including the reduction of Pbp1 localization at distinct cytoplasmic foci and subsequent rescue of TORC1 inhibition in PAS kinase-deficient yeast. In support of this signaling cascade, Snf1-deficient cells display increased TORC1 activity, whereas cells containing hyperactive Snf1 display a PAS kinase-dependent decrease in TORC1 activity. This interplay between yeast SNF1, Psk1, and TORC1 allows for proper glucose allocation during nutrient depletion, reducing cell growth and proliferation when energy is low. © 2015 DeMille et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  18. Spatial spillover effects of a community action programme targeting on-licensed premises on violent assaults: evidence from a natural experiment.

    PubMed

    Brännström, Lars; Trolldal, Björn; Menke, Martin

    2016-03-01

    Spatial dependencies may influence the success of community action strategies to prevent and reduce harmful alcohol use. This study examined the effectiveness of a multicomponent Responsible Beverage Service (RBS) programme targeting on-licensed premises on police-recorded assaults in Swedish municipalities. It was expected that the implementation of the programme within any given municipality had an indirect effect by reducing violent assaults in adjacent municipalities. This study was a natural experiment exploiting the temporal and spatial variation in the implementation of the RBS programme to predict change in the rate of violent assaults in all Swedish municipalities during 1996-2009 (n=288; T=14; N=4 032). Yearly police-recorded violent assaults per 100,000 inhabitants aged 15 and above committed on weekend nights were used as a dependent variable. Programme fidelity was identified by means of survey data. A semilogarithmic fixed-effects spatial panel regression model was used to estimate the direct, indirect and total effects of the programme. The direct, indirect and total effects were -1.8% (95% CI -4.4% to 0.8%), -5.8% (95% CI -11.5% to -0.1%) and -7.6% (95% CI -13.2% to -2.2%), respectively. Averaged over time and across all municipalities, implementing one additional programme component in all municipalities will thus reduce violent assaults in one typical municipality by nearly 8%. The indirect effect of the programme was three times larger than its direct effect. Failing to account for such local spillover effects can result in a considerable underestimation of the programme's total impact and may lead to erroneous policy recommendations. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  19. Current Direction and Velocity Measurements Using GPS Receivers Mounted on Floats at Tom Bevill Lock and Dam

    DTIC Science & Technology

    2002-12-01

    radio and batteries. The procedures outlined in this CHETN will concentrate on the Magellan GPS ProMARK X-CP receiver as it was used to collect...The Magellan GPS ProMARK X-CP is a small robust light receiver that can log 9 hr of both pseudorange and carrier phase satellite data for post...post- processing software, pseudorange GPS data recorded by the ProMARK X-CP can be post-processed differential to achieve 1-3 m (3.3-9.8 ft) horizontal

  20. Direct interaction of the Golgi V-ATPase a-subunit isoform with PI(4)P drives localization of Golgi V-ATPases in yeast.

    PubMed

    Banerjee, Subhrajit; Kane, Patricia M

    2017-09-15

    Luminal pH and phosphoinositide content are fundamental features of organelle identity. Vacuolar H + -ATPases (V-ATPases) drive organelle acidification in all eukaryotes, and membrane-bound a-subunit isoforms of the V-ATPase are implicated in organelle-specific targeting and regulation. Earlier work demonstrated that the endolysosomal lipid PI(3,5)P 2 activates V-ATPases containing the vacuolar a-subunit isoform in Saccharomyces cerevisiae Here we demonstrate that PI(4)P, the predominant Golgi phosphatidylinositol (PI) species, directly interacts with the cytosolic amino terminal (NT) domain of the yeast Golgi V-ATPase a-isoform Stv1. Lysine-84 of Stv1NT is essential for interaction with PI(4)P in vitro and in vivo, and interaction with PI(4)P is required for efficient localization of Stv1-containing V-ATPases. The cytosolic NT domain of the human V-ATPase a2 isoform specifically interacts with PI(4)P in vitro, consistent with its Golgi localization and function. We propose that NT domains of V o a-subunit isoforms interact specifically with PI lipids in their organelles of residence. These interactions can transmit organelle-specific targeting or regulation information to V-ATPases. © 2017 Banerjee and Kane. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  1. Policy making for vaccine use as a driver of vaccine innovation and development in the developed world.

    PubMed

    Seib, Katherine; Pollard, Andrew J; de Wals, Philippe; Andrews, Ross M; Zhou, Fangjun; Hatchett, Richard J; Pickering, Larry K; Orenstein, Walter A

    2017-03-07

    In the past 200years, vaccines have had unmistakable impacts on public health including declines in morbidity and mortality, most markedly in economically-developed countries. Highly engineered vaccines including vaccines for conditions other than infectious diseases are expected to dominate future vaccine development. We examine immunization vaccine policy as a driver of vaccine innovation and development. The pathways to recommendation for use of licensed vaccines in the US, UK, Canada and Australia have been similar, including: expert review of disease epidemiology, disease burden and severity; vaccine immunogenicity, efficacy and safety; programmatic feasibility; public demand; and increasingly cost-effectiveness. Other attributes particularly important in development of future vaccines are likely to include: duration of immunity for improved vaccines such as pertussis; a greater emphasis on optimizing community protection rather than direct protection only; programmatic implementation, feasibility, improvements (as in the case of development of a universal influenza vaccine); public concerns/confidence/fears related to outbreak pathogens like Ebola and Zika virus; and major societal burden for combating hard to treat diseases like HIV and antimicrobial resistant pathogens. Driving innovation and production of future vaccines faces enormous economic hurdles as available approaches, technologies and regulatory pathways become more complex. As such, cost-mitigating strategies and focused, aligned efforts (by governments, private organizations, and private-public partnerships) will likely be needed to continue to spur major advances in vaccine technologies and development. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Estimating the population size and colony boundary of subterranean termites by using the density functions of directionally averaged capture probability.

    PubMed

    Su, Nan-Yao; Lee, Sang-Hee

    2008-04-01

    Marked termites were released in a linear-connected foraging arena, and the spatial heterogeneity of their capture probabilities was averaged for both directions at distance r from release point to obtain a symmetrical distribution, from which the density function of directionally averaged capture probability P(x) was derived. We hypothesized that as marked termites move into the population and given sufficient time, the directionally averaged capture probability may reach an equilibrium P(e) over the distance r and thus satisfy the equal mixing assumption of the mark-recapture protocol. The equilibrium capture probability P(e) was used to estimate the population size N. The hypothesis was tested in a 50-m extended foraging arena to simulate the distance factor of field colonies of subterranean termites. Over the 42-d test period, the density functions of directionally averaged capture probability P(x) exhibited four phases: exponential decline phase, linear decline phase, equilibrium phase, and postequilibrium phase. The equilibrium capture probability P(e), derived as the intercept of the linear regression during the equilibrium phase, correctly projected N estimates that were not significantly different from the known number of workers in the arena. Because the area beneath the probability density function is a constant (50% in this study), preequilibrium regression parameters and P(e) were used to estimate the population boundary distance 1, which is the distance between the release point and the boundary beyond which the population is absent.

  3. KSC-2011-1211

    NASA Image and Video Library

    2011-01-27

    CAPE CANAVERAL, Fla. -- A wreath is displayed at the foot of the Space Mirror Memorial at the Kennedy Space Center Visitor Complex in Florida during a Day of Remembrance ceremony to honor members of the NASA family who lost their lives while furthering the cause of exploration and discovery. The memorial honors 24 United States astronauts, including the crew members of space shuttles Columbia and Challenger, Apollo 1, and those who died in training and commercial airplane accidents. The memorial is a project of the Astronauts Memorial Foundation and was paid for by Florida residents who purchased special Challenger mission automobile license plates. 2011 marks the 25th anniversary of the loss of Challenger, which broke apart over the Atlantic Ocean 73 seconds into flight on Jan. 28, 1986. Photo credit: NASA/Kim Shiflett

  4. KSC-2011-1208

    NASA Image and Video Library

    2011-01-27

    CAPE CANAVERAL, Fla. -- Flowers lay at the foot of the Space Mirror Memorial at the Kennedy Space Center Visitor Complex in Florida before a Day of Remembrance wreath laying ceremony to honor members of the NASA family who lost their lives while furthering the cause of exploration and discovery. The memorial honors 24 United States astronauts, including the crew members of space shuttles Columbia and Challenger, Apollo 1, and those who died in training and commercial airplane accidents. The memorial is a project of the Astronauts Memorial Foundation and was paid for by Florida residents who purchased special Challenger mission automobile license plates. 2011 marks the 25th anniversary of the loss of Challenger, which broke apart over the Atlantic Ocean 73 seconds into flight on Jan. 28, 1986. Photo credit: NASA/Kim Shiflett

  5. Tissue Penetration of Antifungal Agents

    PubMed Central

    Felton, Timothy; Troke, Peter F.

    2014-01-01

    SUMMARY Understanding the tissue penetration of systemically administered antifungal agents is critical for a proper appreciation of their antifungal efficacy in animals and humans. Both the time course of an antifungal drug and its absolute concentrations within tissues may differ significantly from those observed in the bloodstream. In addition, tissue concentrations must also be interpreted within the context of the pathogenesis of the various invasive fungal infections, which differ significantly. There are major technical obstacles to the estimation of concentrations of antifungal agents in various tissue subcompartments, yet these agents, even those within the same class, may exhibit markedly different tissue distributions. This review explores these issues and provides a summary of tissue concentrations of 11 currently licensed systemic antifungal agents. It also explores the therapeutic implications of their distribution at various sites of infection. PMID:24396137

  6. Direct Age Determination of a Subtropical Freshwater Crayfish (Redclaw, Cherax quadricarinatus) Using Ossicular Growth Marks

    PubMed Central

    Leland, Jesse C.; Bucher, Daniel J.; Coughran, Jason

    2015-01-01

    Recent studies have reported that crustacean age determination is possible. We applied a direct ageing method (i.e. transverse cross sectioning of gastric ossicles) to a subtropical freshwater crayfish (Cherax quadricarinatus) sourced from an aquaculture population. Growth mark periodicity and the potential for chronological depositions were investigated by staining C. quadricarinatus with calcein and examining their ossicles a year later. Pterocardiac ossicles were superior to other ageing structures (i.e. other ossicles and eyestalks) and produced repeatable between-reader counts (87% were corroborated and 13% varied by ±1). C. quadricarinatus size-at-age data (for an aquaculture population) was described by a von Bertalanffy growth equation (L ∞ = 32 mm occipital carapace length; K = 0.64; t 0 = –0.18; R2 = 0.81). Ossicular growth marks did not correspond to moult history. The calcein stain was retained over an annual cycle comprising multiple moults, demonstrating that pterocardiac ossicles retain chronological information. The maximum age (3+) corroborated other indirectly-obtained longevity estimates for C. quadricarinatus. Multiple lines of evidence indicate that the growth marks in C. quadricarinatus ossicles are probably deposited annually during winter. The ability to extract age information from subtropical decapods provides substantial opportunities for advancing fisheries and conservation research globally, but further research is needed to provide a definitive validation and elucidate the mechanism governing the accrual of ossicular growth marks. PMID:26309228

  7. Responses of female rock lizards to multiple scent marks of males: effects of male age, male density and scent over-marking.

    PubMed

    Martín, José; López, Pilar

    2013-03-01

    Scent-marked substrates may inform conspecifics on the characteristics of territorial males. Scent-marks of male Carpetan rock lizards (Iberolacerta cyreni) affect space use of females, which by selecting an area may increase the probability of mating with the male that has scent-marked that area. However, males do not hold exclusive territories, and scent-marks of different individual males are often together. This may provide complex information from multiple sources on the social structure. Here, we examined female preference in response to scent marks of various males and combinations in a laboratory experiment. Females preferred areas scent-marked by territorial old males against those scent-marked by young satellite-sneaker males. This reflected the known preference of females for mating with old males. In a second experiment, females preferred areas scent-marked by two males to areas of similar size marked by a single male. This may increase the probability of obtaining multiple copulations with different males, which may favour sperm competition and cryptic female choice, or may be a way to avoid infertile males. Finally, when we experimentally over-marked the scent-marks of an old male with scent-marks of a young male, females did not avoid, nor prefer, the over-marked area, suggesting that the quality of the old male may override the presence of a satellite male. We suggest that, irrespective of the causes underlying why a female selects a scent-marked area, this strategy may affect her reproductive success, which may have the same evolutionary consequences that "direct" mate choice decisions of other animals. Copyright © 2013 Elsevier B.V. All rights reserved.

  8. Current status of poliovirus infections.

    PubMed

    Melnick, J L

    1996-07-01

    Two scientists who played leading roles in the conquest of poliomyelitis died recently. In 1954, Jonas Salk provided the first licensed polio vaccine, the formalin (and heat)-inactivated virus. Albert Sabin gave us the attenuated live virus vaccine, which was licensed in 1962. This paper takes the reader through the history of the disease, including its pathogenesis, epidemiology, vaccines, and future directions. The emphasis is on vaccines, for it seems that with proper vaccination the number of new cases is falling dramatically. It is hoped that by the year 2000, we will accomplish the goal of the World Health Organization of "a world without polio." Then, because there is no animal reservoir, we can seriously discuss when and how to eliminate the need for vaccination and ultimately destroy our stocks of poliovirus.

  9. Current status of poliovirus infections.

    PubMed Central

    Melnick, J L

    1996-01-01

    Two scientists who played leading roles in the conquest of poliomyelitis died recently. In 1954, Jonas Salk provided the first licensed polio vaccine, the formalin (and heat)-inactivated virus. Albert Sabin gave us the attenuated live virus vaccine, which was licensed in 1962. This paper takes the reader through the history of the disease, including its pathogenesis, epidemiology, vaccines, and future directions. The emphasis is on vaccines, for it seems that with proper vaccination the number of new cases is falling dramatically. It is hoped that by the year 2000, we will accomplish the goal of the World Health Organization of "a world without polio." Then, because there is no animal reservoir, we can seriously discuss when and how to eliminate the need for vaccination and ultimately destroy our stocks of poliovirus. PMID:8809461

  10. Patient safety and health policy: a history and review.

    PubMed

    Small, Stephen D; Barach, Paul

    2002-12-01

    Policy initiatives on many fronts have converged to improve patient safety. A major tension that characterizes this process is the attempt to achieve a balance between learning and control in complex systems with technical, social, and organizational components. Efforts to improve learning are marked by better information flow, discovery, flexibility in thinking, embracing of failures as learning opportunities, and core incentives to promote voluntary participation of all stakeholders in the process. Efforts to improve accountability are traditionally marked by public disclosure, meeting of certain widely disseminated standards, availability of performance measures, exposure to legal liability, and compliance with mandated directives (statutes, regulations, accreditation requirements). In some sense, these directions are mutually exclusive. Although a more collaborative regulatory-improvement model would be helpful in creating an industrywide safety culture, it is likely that learning and accountability functions will follow separate tracks. An exception would be policy that stimulates organizations to comply with regulation by showing how well and by what methods they are learning and how others can profit from these experiences. Any approach to improving patient safety should, at a minimum, include a nonpunitive in-depth mechanism for reporting incidents, postincident evaluations for identification of system changes to prevent subsequent occurrences, and state-guaranteed legislative protection from discovery for all aspects of information gathered to improve patient safety. Nonpunitive approaches have yielded useful results in other industries [43]. State and federal courts, state licensing boards, and accrediting bodies such as JCAHO all function to maintain accountability and standards; however, the very fear of existing legal liability or its misapplication are the greatest hurdles to pioneering patient-safety efforts. The health care system needs to transform the existing culture of blame and punishment that suppresses information about errors and adverse events into a culture of safety that focuses on openness and information sharing to improve health care and prevent adverse outcomes. Education and leadership will be most important to creating and sustaining a strong safety culture and arguably the most important defense against preventable harms. Safety culture cannot be legislated, just as the old adage states that it is easier to pull rather than push a piece of spaghetti. Given the imbalances and inefficiencies of market forces in health care, perverse incentives that have strengthened resistance to change, and secrecy when it comes to adverse event information, however, it is likely that policy initiatives will continue to play an important role in the transformation of the industry to more highly reliable, safer levels of care.

  11. Commercialization of LARC (TradeMark) -SI Polyimide Technology

    NASA Technical Reports Server (NTRS)

    Bryant, Robert G.

    2011-01-01

    LARC(TradeMark)-SI, Langley Research Center- Soluble Imide, was developed in 1992, with the first patent issuing in 1997, and then subsequent patents issued in 1998 and 2000. Currently, this polymer has been successfully licensed by NASA, and has generated revenues, at the time of this reporting, in excess of $1.4 million. The success of this particular polymer has been due to many factors and many lessons learned to the point that the invention, while important, is the least significant part in the commercialization of this material. Commercial LARC(TradeMark)-SI is a polyimide composed of two molar equivalents of dianhydrides: 4,4 -oxydiphthalic anhydride (ODPA), and 3,3 ,4,4 -biphenyltetracarboxylic dianhydride (BPDA) and 3,4 -oxydianiline (3,4 -ODA) as the diamine. The unique feature of this aromatic polyimide is that it remains soluble after solution imidization in high-boiling, polar aprotic solvents, even at solids contents of 50-percent by weight. However, once isolated and heated above its T(sub g) of 240 C, it becomes insoluble and exhibits high-temperature thermoplastic melt-flow behavior. With these unique structure property characteristics, it was thought this would be an advantage to have an aromatic polyimide that is both solution and melt processable in the imide form. This could potentially lead to lower cost production as it was not as equipment- or labor-intensive as other high-performance polyimide materials that either precipitate or are intractable. This unique combination of properties allowed patents with broad claim coverage and potential commercialization. After the U.S. Patent applications were filed, a Small Business Innovation Research (SBIR) contract was awarded to Imtec, Inc. to develop and supply the polyimide to NASA and the general public. Some examples of demonstration parts made with LARC(TradeMark)-SI ranged from aircraft wire and multilayer printed-circuit boards, to gears, composite panels, supported adhesive tape, composite coatings, cookware, and polyimide foam. Even with its unique processing characteristics, the thermal and mechanical properties were not drastically different from other solution or meltprocessable polyimides developed by NASA. LARC(TradeMark)-SI risked becoming another interesting, but costly, high-performance material.

  12. What's New: Acquatic Stabilization: Aquatic Rehabilitation Strategies for the Lumbar Spine and Risk Management for the Aquatic Therapist.

    ERIC Educational Resources Information Center

    Moschettti, Marilou

    Through dynamic aquatic stabilization techniques, patients will develop the ability to characterize sensory distractions and develop self-awareness and sensitivity to movement in the water, which will relate directly to improved motor function. Aquatic therapy is a systematic method of treatment, with programs developed by a licensed physical…

  13. 5 CFR 410.307 - Training for promotion or placement in other positions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... directly job-related training to substitute for all or part of the experience (but not education, licensing..., in other agencies, or outside Government—(1) Grade or pay retention. Under the authority of 5 U.S.C... position the employee held before pay retention. (2) Training for placement in another agency. Under the...

  14. 47 CFR 25.148 - Licensing provisions for the Direct Broadcast Satellite Service.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... who do not provide service to Alaska and Hawaii, must provide technical analyses to the Commission demonstrating that such service is not feasible as a technical matter, or that while technically feasible such... § 25.215 (Technical) and § 25.601 (EEO), and in paragraph (f) of this section. Each winner also will be...

  15. 33 CFR 209.140 - Operations of the Corps of Engineers under the Federal Power Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... directing studies to be made. In the case of an application for permit or license for an unconstructed... required to insure coordination of the applicant's studies with the Division or District Engineer in cases... studies, will when requested by the Chief of Engineers submit an estimate of the cost of the investigation...

  16. Labor Market Frictions and Production Efficiency in Public Schools. Working Paper 163

    ERIC Educational Resources Information Center

    Kim, Dongwoo; Koedel, Cory; Ni, Shawn; Podgursky, Michael

    2016-01-01

    State-specific licensing policies and pension plans create mobility costs for educators who cross state lines. We empirically test whether these costs affect production in schools--a hypothesis that follows directly from economic theory on labor frictions--using geo-coded data from the lower-48 states. We find that achievement is lower in…

  17. 10 CFR 32.53 - Luminous safety devices for use in aircraft: Requirements for license to manufacture, assemble...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... maximum quantity of tritium or promethium-147 in each device; (2) Details of construction and design; (3... information, including experimental studies and tests, required by the Commission to facilitate a... direct physical contact by any person with it; (3) The device is so designed that it cannot easily be...

  18. 10 CFR 32.53 - Luminous safety devices for use in aircraft: Requirements for license to manufacture, assemble...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... maximum quantity of tritium or promethium-147 in each device; (2) Details of construction and design; (3... information, including experimental studies and tests, required by the Commission to facilitate a... direct physical contact by any person with it; (3) The device is so designed that it cannot easily be...

  19. Winona State University Anthology of K-12 Action Research Papers

    ERIC Educational Resources Information Center

    Sherman, Thomas F., Ed.; Lundquist, Margaret, Ed.

    2004-01-01

    These papers are partial fulfillment of the requirements for the Master of Science Degree in Education at Winona State University in Winona, Minnesota. The cohort included a variety of licenser areas that represent most levels and content areas of K-12 education. The students were encouraged to keep their questions and hypothesis directed at…

  20. 31 CFR 515.544 - Gifts of Cuban origin goods.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... countries other than Cuba. (b) Specific licenses are issued for the importation directly from Cuba: (1) Of... imported by a person entering the U.S., which are claimed to have been acquired in Cuba as a bona fide gift... to Cuba or nationals thereof from the importation. [39 FR 25317, July 10, 1974; 39 FR 28434, Aug. 7...

  1. A Room with a View: Observations on "Unanticipated" Licensing Agreements and Born Digital Content

    ERIC Educational Resources Information Center

    Lapinski, P. Scott

    2012-01-01

    One of the many challenges that content creators and repository administrators are both struggling with in this "born digital" information environment is the "ownership" of content. After several years of engaging directly with researchers across their campus and providing seminars on the National Institutes of Health (NIH) Public Access Policy,…

  2. Measuring Stability and Security in Iraq

    DTIC Science & Technology

    2009-11-04

    safer for tourists. Additionally, 24 signed investment licenses totaling $1.122 billion have been directed toward tourism and hospitality industries...the U.S.-Iraq SA, and in accordance with the Presidential guidance articulated February 27, 2009, is the plan being executed for the responsible...conducting detention facility assessments, and inadequate ministerial coordination and planning remain unresolved. In summary, political

  3. The Current State of Early Childhood Education Programs: How Early Childhood Center Directors Manage Their Human Resources

    ERIC Educational Resources Information Center

    Arend, Lauren E.

    2010-01-01

    Purpose: Research in the field of early childhood education (ECE) demonstrated the association between skilled directors and high quality programs. Still, most state licensing requirements do not delineate the requisite knowledge or experience necessary to be an effective director. Many ECE directors advance to their position directly from the…

  4. 78 FR 12655 - Federal-State Unemployment Insurance (UI) Program; Data Exchange Standardization as Required by...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-25

    ... of individuals who have participated in workforce investment programs in SWAs; The UI Inquiry data... modules to be developed and direct these funds to NASWA for the development of these modules. All SWAs... Maryland Department of Labor, Licensing and Regulation acts as the Department's agent to contract with a...

  5. Academic Innovation in the Commercial Domain: Case Studies of Successful Transfers of University-Developed Technologies.

    ERIC Educational Resources Information Center

    Powers, Joshua B.

    In recent years, considerable attention has been directed toward higher educations role as a driver of economic reform. Yet, surprisingly little is known about the processes and mechanisms by which academic innovations are successfully commercialized. The specific question is, what factors explain why some licensed innovations become bona fide…

  6. The Action-Sentence Compatibility Effect: It's All in the Timing

    ERIC Educational Resources Information Center

    Borreggine, Kristin L.; Kaschak, Michael P.

    2006-01-01

    When participants are asked to make sensibility judgments on sentences that describe action toward the body (i.e., "Mark dealt the cards to you") or away from the body (i.e., "You dealt the cards to Mark"), they are faster to respond when the response requires an arm movement in the same direction as the action described by the sentence. This…

  7. Detection of nitro-organic and peroxide explosives in latent fingermarks by DART- and SALDI-TOF-mass spectrometry.

    PubMed

    Rowell, Frederick; Seviour, John; Lim, Angelina Yimei; Elumbaring-Salazar, Cheryl Grace; Loke, Jason; Ma, Jan

    2012-09-10

    The ability of two mass spectrometric methods, surface-assisted laser desorption/ionization-time of flight-mass spectrometry (SALDI-TOF-MS) and direct analysis in real time (DART-MS), to detect the presence of seven common explosives (six nitro-organic- and one peroxide-type) in spiked latent fingermarks has been examined. It was found that each explosive could be detected with nanogram sensitivity for marks resulting from direct finger contact with a glass probe by DART-MS or onto stainless steel target plates using SALDI-TOF-MS for marks pre-dusted with one type of commercial black magnetic powder. These explosives also could be detected in latent marks lifted from six common surfaces (paper, plastic bag, metal drinks can, wood laminate, adhesive tape and white ceramic tile) whereas no explosive could be detected in equivalent pre-dusted marks on the surface of a commercial lifting tape by the DART-MS method due to high background interference from the tape material. The presence of TNT and Tetryl could be detected in pre-dusted latent fingermarks on a commercial lifting tape for up to 29 days sealed and stored under ambient conditions. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  8. Segmentation and classification of road markings using MLS data

    NASA Astrophysics Data System (ADS)

    Soilán, Mario; Riveiro, Belén; Martínez-Sánchez, Joaquín; Arias, Pedro

    2017-01-01

    Traffic signs are one of the most important safety elements in a road network. Particularly, road markings provide information about the limits and direction of each road lane, or warn the drivers about potential danger. The optimal condition of road markings contributes to a better road safety. Mobile Laser Scanning technology can be used for infrastructure inspection and specifically for traffic sign detection and inventory. This paper presents a methodology for the detection and semantic characterization of the most common road markings, namely pedestrian crossings and arrows. The 3D point cloud data acquired by a LYNX Mobile Mapper system is filtered in order to isolate reflective points in the road, and each single element is hierarchically classified using Neural Networks. State of the art results are obtained for the extraction and classification of the markings, with F-scores of 94% and 96% respectively. Finally, data from classified markings are exported to a GIS layer and maintenance criteria based on the aforementioned data are proposed.

  9. High contrast laser marking of alumina

    NASA Astrophysics Data System (ADS)

    Penide, J.; Quintero, F.; Riveiro, A.; Fernández, A.; del Val, J.; Comesaña, R.; Lusquiños, F.; Pou, J.

    2015-05-01

    Alumina serves as raw material for a broad range of advanced ceramic products. These elements should usually be identified by some characters or symbols printed directly on them. In this sense, laser marking is an efficient, reliable and widely implemented process in industry. However, laser marking of alumina still leads to poor results since the process is not able to produce a dark mark, yielding bad contrast. In this paper, we present an experimental study on the process of marking alumina by three different lasers working in two wavelengths: 1064 nm (Near-infrared) and 532 nm (visible, green radiation). A colorimetric analysis has been carried out in order to compare the resulting marks and its contrast. The most suitable laser operating conditions were also defined and are reported here. Moreover, the physical process of marking by NIR lasers is discussed in detail. Field Emission Scanning Electron Microscopy, High Resolution Transmission Electron Microscopy and X-ray Photoelectron Spectroscopy were also employed to analyze the results. Finally, we propose an explanation for the differences of the coloration induced under different atmospheres and laser parameters. We concluded that the atmosphere is the key parameter, being the inert one the best choice to produce the darkest marks.

  10. Cultural and Species Differences in Gazing Patterns for Marked and Decorated Objects: A Comparative Eye-Tracking Study

    PubMed Central

    Mühlenbeck, Cordelia; Jacobsen, Thomas; Pritsch, Carla; Liebal, Katja

    2017-01-01

    Objects from the Middle Paleolithic period colored with ochre and marked with incisions represent the beginning of non-utilitarian object manipulation in different species of the Homo genus. To investigate the visual effects caused by these markings, we compared humans who have different cultural backgrounds (Namibian hunter–gatherers and German city dwellers) to one species of non-human great apes (orangutans) with respect to their perceptions of markings on objects. We used eye-tracking to analyze their fixation patterns and the durations of their fixations on marked and unmarked stones and sticks. In an additional test, humans evaluated the objects regarding their aesthetic preferences. Our hypotheses were that colorful markings help an individual to structure the surrounding world by making certain features of the environment salient, and that aesthetic appreciation should be associated with this structuring. Our results showed that humans fixated on the marked objects longer and used them in the structural processing of the objects and their background, but did not consistently report finding them more beautiful. Orangutans, in contrast, did not distinguish between object and background in their visual processing and did not clearly fixate longer on the markings. Our results suggest that marking behavior is characteristic for humans and evolved as an attention-directing rather than aesthetic benefit. PMID:28167923

  11. Investigation of molecular mechanism of recognition between citral and MARK4: A newer therapeutic approach to attenuate cancer cell progression.

    PubMed

    Naz, Farha; Khan, Faez Iqbal; Mohammad, Taj; Khan, Parvez; Manzoor, Saaliqa; Hasan, Gulam Mustafa; Lobb, Kevin A; Luqman, Suaib; Islam, Asimul; Ahmad, Faizan; Hassan, Md Imtaiyaz

    2018-02-01

    Microtubule affinity regulating kinase 4 (MARK4) is a member of AMP-activated protein kinase, found to be involved in apoptosis, inflammation and many other regulatory pathways. Since, its aberrant expression is directly associated with the cell cycle and thus cancer. Therefore, MARK4 is being considered as a potential drug target for cancer therapy. Here, we investigated the mechanism of inhibition of MARK4 activity by citral. Docking studies suggested that citral effectively binds to the active site cavity, and complex is stabilized by several interactions. We further performed molecular dynamics simulation of MARK4-citral complex under explicit water condition for 100ns and observed that binding of citral to MARK4 was quite stable. Fluorescence binding studies suggested that citral strongly binds to MARK4 and thereby inhibits its enzyme activity which was measured by the kinase inhibition assay. We further performed MTT assay and observed that citral inhibits proliferation of breast cancer cell line MCF-7. This work provides a newer insight into the use of citral as novel cancer therapeutics through the MARK4 inhibition. Results may be employed to design novel therapeutic molecule using citral as a scaffold for MARK4 inhibition to fight related diseases. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. No longer "if," but "when": the coming abbreviated approval pathway for follow-on biologics.

    PubMed

    Kelly, Jeremiah J; David, Michael

    2009-01-01

    Abbreviated approval of follow-on biologics involves answering complex scientific, legal, and policy questions. The Food and Drug Administration (FDA or the Agency) asserts that it lacks the statutory authority to approve follow-on versions of biologics licensed under Section 351 of the Public Health Service Act (PHSA). Despite persuasive arguments to the contrary the one hundred and tenth Congress entertained four legislative proposals to give FDA this authority, each markedly different. It is no longer a question of "if," but "when" FDA will receive authority to review and license abbreviated applications for follow-on biologics. Any legislation in the one hundred and eleventh Congress must determine: (1) if FDA should be granted authority to develop an abbreviated pathway through rulemaking or guidance; (2) if human clinical trials should be mandatory or discretionary; (3) the feasibility of interchangeability determinations in light of patient safety concerns; (4) the duration of marketing exclusivity for associated products; (5) which products are eligible for follow-on approval; and (6) the degree to which uniformity is achievable between the FD&C Act and the PHSA. This paper recommends the one hundred and eleventh Congress strike a balance between patient safety, incentives for product innovation, price competition, and the need for a flexible, transparent process that capitalizes on FDA's growing expertise with follow-on biologics approvals under Section 505(b)(2) of the FD&C Act.

  13. Bioethics, Human Rights, and Childbirth.

    PubMed

    Erdman, Joanna

    2015-06-11

    The global reproductive justice community has turned its attention to the abuse and disrespect that many women suffer during facility-based childbirth. In 2014, the World Health Organization released a statement on the issue, endorsed by more than 80 civil society and health professional organizations worldwide.The statement acknowledges a growing body of research that shows widespread patterns of women's mistreatment during labor and delivery-physical and verbal abuse, neglect and abandonment, humiliation and punishment, coerced and forced care-in a range of health facilities from basic rural health centers to tertiary care hospitals. Moreover, the statement characterizes this mistreatment as a human rights violation. It affirms: "Every woman has the right to the highest attainable standard of health, which includes the right to dignified, respectful health care throughout pregnancy and childbirth."The WHO statement and the strong endorsement of it mark a critical turn in global maternal rights advocacy. It is a turn from the public health world of systems and resources in preventing mortality to the intimate clinical setting of patient and provider in ensuring respectful care. Copyright 2015 Erdman. This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

  14. Thermal Conductivity of Ultem(TradeMark)/Carbon Nanofiller Blends

    NASA Technical Reports Server (NTRS)

    Ghose, S.; Watson, K. A.; Delozier, D. M.; Working, D. C.; Connell, J. W.; Smith, J. G., Jr.; Sun, Y. P.; Lin, Y.

    2006-01-01

    In an effort to improve polymer thermal conductivity (TC), Ultem(TradeMark) 1000 was compounded with nano-fillers of carbon allotropes. Ultem(TradeMark) 1000 was selected since it is both solution and melt processable. As-received and modified multiwalled carbon nanotubes (MWCNTs), vapor grown carbon nanofibers (CNF) and expanded graphite (EG) were investigated. MWCNTs were modified by functionalizing the surface through oxidization with concentrated acids, mixing with an alkyl bromide, and addition of alkyl and phosphorus compounds after initial treatment with n-butyl lithium. Functionalization was performed to improve the TC compatibility between the resin and MWCNTs. It was postulated that this may provide an improved interface between the MWCNT and the polymer which would result in enhanced TC. The nano-fillers were mixed with Ultem(TradeMark) 1000 in the melt and in solution at concentrations ranging from 5 to 40 wt%. Ribbons were extruded from the blends to form samples where the nano-fillers were aligned to some degree in the extrusion direction. Samples were also fabricated by compression molding resulting in random orientation of the nano-fillers. Thermal properties of the samples were evaluated by Differential Scanning Calorimetry (DSC) and Thermal Gravimetric Analyzer (TGA). Tensile properties of aligned samples were determined at room temperature. The specimens were cut from the ribbons in the extrusion direction; hence the nano-fillers are somewhat aligned in the direction of stress. Typically it was observed that melt mixed samples exhibited superior mechanical properties compared to solution mixed samples. As expected, increased filler loading led to increased modulus and decreased elongation with respect to the neat polymer. The degree of dispersion and alignment of the nano-fillers was determined by high-resolution scanning electron microscopy (HRSEM). HRSEM of the ribbons revealed that the MWCNTs and CNFs were predominantly aligned in the flow direction. The TC of the samples was measured using a Nanoflash(TradeMark) instrument. Since the MWCNTs and CNF are anisotropic, the TC was expected to be different in the longitudinal (parallel to the nanotube and fiber axis) and transverse (perpendicular to the nanotube and fiber axis) directions. The extruded ribbons provided samples for transverse TC measurements. However, to determine the TC in the longitudinal direction, the ribbons needed to be stacked and molded under 1.7 MPa and 270 C. Samples were then obtained by cutting the molded block with a diamond saw. The largest TC improvement was achieved for aligned samples when the measurement was performed in the direction of MWCNT and CNF alignment (i.e. longitudinal axis). Unaligned samples also showed a significant improvement in TC and may be potentially useful in applications when it is not possible to align the nano-filler. The results of this study will be presented.

  15. Everlasting Dark Printing on Alumina by Laser

    NASA Astrophysics Data System (ADS)

    Penide, J.; Quintero, F.; Arias-González, F.; Fernández, A.; del Val, J.; Comesaña, R.; Riveiro, A.; Lusquiños, F.; Pou, J.

    Marks or prints are needed in almost every material, mainly for decorative or identification purposes. Despite alumina is widely employed in many different industries, the need of printing directly on its surface is still a complex problem. In this sense, lasers have largely demonstrated their high capacities to mark almost every material including ceramics, but performing dark permanent marks on alumina is still an open challenge. In this work we present the results of a comprehensive experimental analysis on the process of marking alumina by laser. Four different laser sources were used in this study: a fiber laser (1075 nm) and three diode pumped Nd:YVO4 lasers emitting at near-infrared (1064 nm), visible (532 nm) and ultraviolet (355 nm) wavelengths, respectively. The results obtained with the four lasers were compared and physical processes involved were explained in detail. Colorimetric analyses allowed to identify the optimal parameters and conditions to produce everlasting and high contrast marks on alumina.

  16. 10 CFR 171.15 - Annual fees: Reactor licenses and independent spent fuel storage licenses.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Annual fees: Reactor licenses and independent spent fuel... REACTOR LICENSES AND FUEL CYCLE LICENSES AND MATERIALS LICENSES, INCLUDING HOLDERS OF CERTIFICATES OF... NRC § 171.15 Annual fees: Reactor licenses and independent spent fuel storage licenses. (a) Each...

  17. 10 CFR 171.15 - Annual fees: Reactor licenses and independent spent fuel storage licenses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Annual fees: Reactor licenses and independent spent fuel... REACTOR LICENSES AND FUEL CYCLE LICENSES AND MATERIALS LICENSES, INCLUDING HOLDERS OF CERTIFICATES OF... NRC § 171.15 Annual fees: Reactor licenses and independent spent fuel storage licenses. (a) Each...

  18. Student-directed retrieval practice is a predictor of medical licensing examination performance.

    PubMed

    Deng, Francis; Gluckstein, Jeffrey A; Larsen, Douglas P

    2015-12-01

    A large body of evidence indicates that retrieval practice (test-enhanced learning) and spaced repetition increase long-term information retention. Implementation of these strategies in medical curricula is unfortunately limited. However, students may choose to apply them autonomously when preparing for high-stakes, cumulative assessments, such as the United States Medical Licensing Examination Step 1. We examined the prevalence of specific self-directed methods of testing, with or without spaced repetition, among preclinical students and assessed the relationship between these methods and licensing examination performance. Seventy-two medical students at one institution completed a survey concerning their use of user-generated (Anki) or commercially-available (Firecracker) flashcards intended for spaced repetition and of boards-style multiple-choice questions (MCQs). Other information collected included Step 1 score, past academic performance (Medical College Admission Test [MCAT] score, preclinical grades), and psychological factors that may have affected exam preparation or performance (feelings of depression, burnout, and test anxiety). All students reported using practice MCQs (mean 3870, SD 1472). Anki and Firecracker users comprised 31 and 49 % of respondents, respectively. In a multivariate regression model, significant independent predictors of Step 1 score included MCQs completed (unstandardized beta coefficient [B] = 2.2 × 10 - 3 , p < 0.001), unique Anki flashcards seen (B = 5.9 × 10 - 4 , p = 0.024), second-year honours (B = 1.198, p = 0.002), and MCAT score (B = 1.078, p = 0.003). Test anxiety was a significant negative predictor (B= - 1.986, p < 0.001). Unique Firecracker flashcards seen did not predict Step 1 score. Each additional 445 boards-style practice questions or 1700 unique Anki flashcards was associated with an additional point on Step 1 when controlling for other academic and psychological factors. Medical students engage extensively in self-initiated retrieval practice, often with spaced repetition. These practices are associated with superior performance on a medical licensing examination and should be considered for formal support by educators.

  19. Teaching Assistant Professional Development in Biology: Designed for and Driven by Multidimensional Data.

    PubMed

    Wyse, Sara A; Long, Tammy M; Ebert-May, Diane

    2014-01-01

    Graduate teaching assistants (TAs) are increasingly responsible for instruction in undergraduate science, technology, engineering, and mathematics (STEM) courses. Various professional development (PD) programs have been developed and implemented to prepare TAs for this role, but data about effectiveness are lacking and are derived almost exclusively from self-reported surveys. In this study, we describe the design of a reformed PD (RPD) model and apply Kirkpatrick's Evaluation Framework to evaluate multiple outcomes of TA PD before, during, and after implementing RPD. This framework allows evaluation that includes both direct measures and self-reported data. In RPD, TAs created and aligned learning objectives and assessments and incorporated more learner-centered instructional practices in their teaching. However, these data are inconsistent with TAs' self-reported perceptions about RPD and suggest that single measures are insufficient to evaluate TA PD programs. © 2014 Wyse et al. CBE—Life Sciences Education © 2014 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  20. Diplopia and driving: a problematic issue.

    PubMed

    Righi, Stefano; Boffano, Paolo; Guglielmi, Valeria; Rossi, Paolo; Martorina, Massimo

    2014-10-01

    The aim of this article was to review the literature regarding diplopia and driving license and to review the West European legislations about this topic, in order to obtain appropriate indications for hospitals specialists and patients. A systematic review of articles published about diplopia and driving was performed. In addition a review of West European national legislations about driving license regulations for medical illnesses was performed, in addition to the European Union Directive on driving licenses. In the literature, the presence of diplopia has not been considered a reliable predictor of the safety of driving behavior, or it has not appeared to be a contraindication for driving according to some authors who were unable to demonstrate significant differences on driving simulator performance between subjects with chronic stable diplopia and control subjects. Nevertheless, in all western European legislations, acute diplopia constitutes an important limitation for driving, thus making the knowledge of current regulations fundamental for specialists involved in managing patients with diplopia. Ophthalmologists and maxillofacial/head and neck surgeons, may advise patients before hospital discharge about current legislations in their respective countries. Copyright © 2014 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  1. STEM Faculty as Learners in Pedagogical Reform and the Role of Research Articles as Professional Development Opportunities.

    PubMed

    Mulnix, Amy B

    2016-01-01

    Discipline-based education research (DBER) publications are opportunities for professional development around science, technology, engineering, and mathematics (STEM) education reform. Learning theory tells us these publications could be more impactful if authors, reviewers, and editors pay greater attention to linking principles and practice. This approach, which considers faculty as learners and STEM education reform as content, has the potential to better support faculty members because it promotes a deeper understanding of the reasons why a pedagogical change is effective. This depth of understanding is necessary for faculty members to successfully transfer new knowledge to their own contexts. A challenge ahead for the emergent learning sciences is to better integrate findings from across sister disciplines; DBER reports can take a step in that direction while improving their usefulness for instructors. © 2016 A. B. Mulnix. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  2. A Phenomenological Study of the Office Environments of Clinical Social Workers.

    PubMed

    Jones, Jamie K

    2018-01-01

    The purpose of this study was to explore the meaning and uses of the office space among licensed clinical social workers in private practice. Previous research suggests the importance of the office space in clinical practice in regard to therapeutic alliance, client behavior, and the well-being of the therapist. However, therapist offices contain much variation in design. This study looked further into specifically how the therapy room is important through the perspective of the licensed clinical social workers in order to identify common themes. Seven licensed clinical social workers in private psychotherapy practice were interviewed in their offices. Phenomenological research methods were used to explore and analyze their experiences. While the offices contained many physical differences, the intentions behind the designs were similar. Three themes emerged regarding how participants used and designed their spaces. First, participants used their offices to provide care for clients and themselves. Second, participants used their spaces to communicate therapeutic messages and to reveal and/or conceal aspects of themselves. Third, participants also used their space in direct practice. This phenomenological study provided insight into the importance and use of the psychotherapy office space. These findings may be helpful for therapists designing or redesigning their own practice spaces.

  3. Quantitative cell biology: the essential role of theory.

    PubMed

    Howard, Jonathon

    2014-11-05

    Quantitative biology is a hot area, as evidenced by the recent establishment of institutes, graduate programs, and conferences with that name. But what is quantitative biology? What should it be? And how can it contribute to solving the big questions in biology? The past decade has seen very rapid development of quantitative experimental techniques, especially at the single-molecule and single-cell levels. In this essay, I argue that quantitative biology is much more than just the quantitation of these experimental results. Instead, it should be the application of the scientific method by which measurement is directed toward testing theories. In this view, quantitative biology is the recognition that theory and models play critical roles in biology, as they do in physics and engineering. By tying together experiment and theory, quantitative biology promises a deeper understanding of underlying mechanisms, when the theory works, or to new discoveries, when it does not. © 2014 Howard. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  4. 75 FR 66007 - Mark Edward Leyse; Mark Edward Leyse and Raymond Shadis, on Behalf of the New England Coalition...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-27

    ... cladding temperature in order to provide a necessary margin of safety in the event of a loss-of-coolant... confirming that we have received your comments, contact us directly at 301-415-1677. Hand-deliver comments to...-conservative in their peak cladding temperature limit of 2200 [deg]F, and that the Baker-Just and Cathcart...

  5. MENC in International Perspective: In Its First One Hundred Years, MENC Has Had an Impact on Music Education Not Only in the United States, but Globally

    ERIC Educational Resources Information Center

    McCarthy, Marie

    2007-01-01

    The year 2007 marks the centennial celebration of MENC: The National Association for Music Education. Anniversaries mark important milestones in the development of a professional association. They provide an occasion for remembering past achievements and envisioning future directions. MENC, which was initially known as Music Supervisors National…

  6. 75 FR 70861 - Airworthiness Directives; Fokker Services B.V. Model F.28 Mark 0100, 1000, 2000, 3000, and 4000...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-19

    ... source can develop in the wing tank vapour space during fuel transfer from bag tank CWT [center wing tank... vapour space during fuel transfer from bag tank CWT [center wing tank], if the electrical power for... with a center wing tank (CWT); and Model F28 Mark 0100 airplanes, serial numbers 11244 through 11441...

  7. Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions.

    PubMed

    Picco, Gabriele; Petti, Consalvo; Centonze, Alessia; Torchiaro, Erica; Crisafulli, Giovanni; Novara, Luca; Acquaviva, Andrea; Bardelli, Alberto; Medico, Enzo

    2017-03-01

    In colorectal cancer (CRC), WNT pathway activation by genetic rearrangements of RSPO3 is emerging as a promising target. However, its low prevalence severely limits availability of preclinical models for in-depth characterization. Using a pipeline designed to suppress stroma-derived signal, we find that RSPO3 "outlier" expression in CRC samples highlights translocation and fusion transcript expression. Outlier search in 151 CRC cell lines identified VACO6 and SNU1411 cells as carriers of, respectively, a canonical PTPRK(e1)-RSPO3(e2) fusion and a novel PTPRK(e13)-RSPO3(e2) fusion. Both lines displayed marked in vitro and in vivo sensitivity to WNT blockade by the porcupine inhibitor LGK974, associated with transcriptional and morphological evidence of WNT pathway suppression. Long-term treatment of VACO6 cells with LGK974 led to the emergence of a resistant population carrying two frameshift deletions of the WNT pathway inhibitor AXIN1, with consequent protein loss. Suppression of AXIN1 in parental VACO6 cells by RNA interference conferred marked resistance to LGK974. These results provide the first mechanism of secondary resistance to WNT pathway inhibition. © 2017 The Authors. Published under the terms of the CC BY 4.0 license.

  8. Concealed wire tracing apparatus

    DOEpatents

    Kronberg, J.W.

    1994-05-31

    An apparatus and method that combines a signal generator and a passive signal receiver to detect and record the path of partially or completely concealed electrical wiring without disturbing the concealing surface is disclosed. The signal generator applies a series of electrical pulses to the selected wiring of interest. The applied pulses create a magnetic field about the wiring that can be detected by a coil contained within the signal receiver. An audible output connected to the receiver and driven by the coil reflects the receivers position with respect to the wiring. The receivers audible signal is strongest when the receiver is directly above the wiring and the long axis of the receivers coil is parallel to the wiring. A marking means is mounted on the receiver to mark the location of the wiring as the receiver is directed over the wiring's concealing surface. Numerous marks made on various locations of the concealing surface will trace the path of the wiring of interest. 4 figs.

  9. Bioactivity and laundering resistance of five commercially available, factory-treated permethrin-impregnated fabrics for the prevention of mosquito-borne diseases: the need for a standardized testing and licensing procedure.

    PubMed

    Faulde, Michael K; Pages, Frederic; Uedelhoven, Waltraud

    2016-04-01

    Personal protective measures against hematophagous vectors constitute the first line of defense against arthropod-borne diseases. In this regard, a major advance has been the development of residual insecticides that can be impregnated into clothing. Currently, however, information on specific treatment procedures, initial insecticide concentrations, arthropod toxicity, residual activity, and laundering resistance is either fragmentary or non-existent, and no World Health Organization Pesticides Evaluation Scheme or other guidelines exist for the standardized testing and licensing of insecticide-treated clothing. The aim of this study was to analyze the insecticide content, contact toxicity, laundering resistance, and residual activity of five commercially available and commonly used permethrin-treated fabrics-Insect Shield, ExOfficio, Sol's Monarch T-shirts, battle dress uniforms (BDUs), and Labonal socks-against vector-competent Aedes aegypti, Anopheles stephensi, and Culex pipiens mosquitoes under laboratory conditions. Prior to laundering, permethrin concentrations ranged from 4300 to 870 mg/m(2) whereas, after 100 defined machine launderings, the remaining permethrin content fell to between 1800 and 20 mg/m(2), a percentage permethrin loss of 58.1 to 98.5 %. The highest 99 % knockdown (KD99) efficacy of permethrin was detected in Ae. aegypti, followed by An. stephensi and Cx. pipiens demonstrating that Ae. aegypti is the most sensitive species and Cx. pipiens the least sensitive. After 100 launderings, the remaining biocidal efficacy differed markedly among the five brands, with KD99 times varying from 38.8 ± 2.9 to >360 min for Ae. aegypti, from 44 ± 3.5 to >360 min for An. stephensi, and from 98 ± 10.6 to >360 min for Cx. pipiens. Overall, the ranking of the residual biocidal efficacies within the five brands tested was as follows: BDU ≈ Labonal > Sol's Monarch > ExOfficio > Insect Shield. When applying German Armed Forces licensing conditions, none of the four products available in the civilian market would completely meet all the necessary efficacy and safety requirements fulfilled by BDUs. Therefore, we strongly recommend standardized testing and licensing procedures for insecticide-treated clothing, with defined cutoff values for initial maximum and post-laundering minimum concentrations of permethrin as well as figures for permethrin migration rates, arthropod toxicity, homogeneity on fabrics, residual activity, and laundering resistance.

  10. A Social Capital Perspective on the Mentoring of Undergraduate Life Science Researchers: An Empirical Study of Undergraduate-Postgraduate-Faculty Triads.

    PubMed

    Aikens, Melissa L; Sadselia, Sona; Watkins, Keiana; Evans, Mara; Eby, Lillian T; Dolan, Erin L

    2016-01-01

    Undergraduate researchers at research universities are often mentored by graduate students or postdoctoral researchers (referred to collectively as "postgraduates") and faculty, creating a mentoring triad structure. Triads differ based on whether the undergraduate, postgraduate, and faculty member interact with one another about the undergraduate's research. Using a social capital theory framework, we hypothesized that different triad structures provide undergraduates with varying resources (e.g., information, advice, psychosocial support) from the postgraduates and/or faculty, which would affect the undergraduates' research outcomes. To test this, we collected data from a national sample of undergraduate life science researchers about their mentoring triad structure and a range of outcomes associated with research experiences, such as perceived gains in their abilities to think and work like scientists, science identity, and intentions to enroll in a PhD program. Undergraduates mentored by postgraduates alone reported positive outcomes, indicating that postgraduates can be effective mentors. However, undergraduates who interacted directly with faculty realized greater outcomes, suggesting that faculty interaction is important for undergraduates to realize the full benefits of research. The "closed triad," in which undergraduates, postgraduates, and faculty all interact directly, appeared to be uniquely beneficial; these undergraduates reported the highest gains in thinking and working like a scientist. © 2016 M. L. Aikens et al. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  11. Munc13-4 functions as a Ca2+ sensor for homotypic secretory granule fusion to generate endosomal exocytic vacuoles.

    PubMed

    Woo, Sang Su; James, Declan J; Martin, Thomas F J

    2017-03-15

    Munc13-4 is a Ca 2+ -dependent SNARE (soluble N -ethylmaleimide-sensitive factor attachment protein receptor)- and phospholipid-binding protein that localizes to and primes secretory granules (SGs) for Ca 2+ -evoked secretion in various secretory cells. Studies in mast cell-like RBL-2H3 cells provide direct evidence that Munc13-4 with its two Ca 2+ -binding C2 domains functions as a Ca 2+ sensor for SG exocytosis. Unexpectedly, Ca 2+ stimulation also generated large (>2.4 μm in diameter) Munc13-4 + /Rab7 + /Rab11 + endosomal vacuoles. Vacuole generation involved the homotypic fusion of Munc13-4 + /Rab7 + SGs, followed by a merge with Rab11 + endosomes, and depended on Ca 2+ binding to Munc13-4. Munc13-4 promoted the Ca 2+ -stimulated fusion of VAMP8-containing liposomes with liposomes containing exocytic or endosomal Q-SNAREs and directly interacted with late endosomal SNARE complexes. Thus Munc13-4 is a tethering/priming factor and Ca 2+ sensor for both heterotypic SG-plasma membrane and homotypic SG-SG fusion. Total internal reflection fluorescence microscopy imaging revealed that vacuoles were exocytic and mediated secretion of β-hexosaminidase and cytokines accompanied by Munc13-4 diffusion onto the plasma membrane. The results provide new molecular insights into the mechanism of multigranular compound exocytosis commonly observed in various secretory cells. © 2017 Woo et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  12. Trends in Compulsory Licensing of Pharmaceuticals Since the Doha Declaration: A Database Analysis

    PubMed Central

    Beall, Reed; Kuhn, Randall

    2012-01-01

    Background It is now a decade since the World Trade Organization (WTO) adopted the “Declaration on the TRIPS Agreement and Public Health” at its 4th Ministerial Conference in Doha. Many anticipated that these actions would lead nations to claim compulsory licenses (CLs) for pharmaceutical products with greater regularity. A CL is the use of a patented innovation that has been licensed by a state without the permission of the patent title holder. Skeptics doubted that many CLs would occur, given political pressure against CL activity and continued health system weakness in poor countries. The subsequent decade has seen little systematic assessment of the Doha Declaration's impact. Methods and Findings We assembled a database of all episodes in which a CL was publically entertained or announced by a WTO member state since 1995. Broad searches of CL activity were conducted using media, academic, and legal databases, yielding 34 potential CL episodes in 26 countries. Country- and product-specific searches were used to verify government participation, resulting in a final database of 24 verified CLs in 17 nations. We coded CL episodes in terms of outcome, national income, and disease group over three distinct periods of CL activity. Most CL episodes occurred between 2003 and 2005, involved drugs for HIV/AIDS, and occurred in upper-middle-income countries (UMICs). Aside from HIV/AIDS, few CL episodes involved communicable disease, and none occurred in least-developed or low-income countries. Conclusions Given skepticism about the Doha Declaration's likely impact, we note the relatively high occurrence of CLs, yet CL activity has diminished markedly since 2006. While UMICs have high CL activity and strong incentives to use CLs compared to other countries, we note considerable countervailing pressures against CL use even in UMICs. We conclude that there is a low probability of continued CL activity. We highlight the need for further systematic evaluation of global health governance actions. Please see later in the article for the Editors' Summary PMID:22253577

  13. Trends in compulsory licensing of pharmaceuticals since the Doha Declaration: a database analysis.

    PubMed

    Beall, Reed; Kuhn, Randall

    2012-01-01

    It is now a decade since the World Trade Organization (WTO) adopted the "Declaration on the TRIPS Agreement and Public Health" at its 4th Ministerial Conference in Doha. Many anticipated that these actions would lead nations to claim compulsory licenses (CLs) for pharmaceutical products with greater regularity. A CL is the use of a patented innovation that has been licensed by a state without the permission of the patent title holder. Skeptics doubted that many CLs would occur, given political pressure against CL activity and continued health system weakness in poor countries. The subsequent decade has seen little systematic assessment of the Doha Declaration's impact. We assembled a database of all episodes in which a CL was publically entertained or announced by a WTO member state since 1995. Broad searches of CL activity were conducted using media, academic, and legal databases, yielding 34 potential CL episodes in 26 countries. Country- and product-specific searches were used to verify government participation, resulting in a final database of 24 verified CLs in 17 nations. We coded CL episodes in terms of outcome, national income, and disease group over three distinct periods of CL activity. Most CL episodes occurred between 2003 and 2005, involved drugs for HIV/AIDS, and occurred in upper-middle-income countries (UMICs). Aside from HIV/AIDS, few CL episodes involved communicable disease, and none occurred in least-developed or low-income countries. Given skepticism about the Doha Declaration's likely impact, we note the relatively high occurrence of CLs, yet CL activity has diminished markedly since 2006. While UMICs have high CL activity and strong incentives to use CLs compared to other countries, we note considerable countervailing pressures against CL use even in UMICs. We conclude that there is a low probability of continued CL activity. We highlight the need for further systematic evaluation of global health governance actions. Please see later in the article for the Editors' Summary.

  14. JPRS Report, East Europe

    DTIC Science & Technology

    1988-03-09

    food , and the development of high quality public eating establishments. One must add that in recent years consumer goods cooperatives have taken...their planned tasks—establishing direct relationships , the usual foreign trade operations, purchase of licenses, etc. The introduction of new...service in the consumer goods sector. Indeed, this figure can hide poor management, closed sales outlets and restaurants , and sales people who work

  15. 15 CFR Supplement No. 2 to Part 748 - Unique Application and Submission Requirements

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... tools, dimensional inspection machines, direct numerical control systems, specially designed assemblies... Commerce Control List (§ 774.1 of the EAR)—see Category 5 Part 1 Notes 1 and 2 and Part 2 Note 1. License... containing computers to destinations in Country Group D:1 (See Supplement No. 1 to part 740 of the EAR), or...

  16. 15 CFR Supplement No. 2 to Part 748 - Unique Application and Submission Requirements

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... tools, dimensional inspection machines, direct numerical control systems, specially designed assemblies... Commerce Control List (§ 774.1 of the EAR)—see Category 5 Part 1 Notes 1 and 2 and Part 2 Note 1. License... containing computers to destinations in Country Group D:1 (See Supplement No. 1 to part 740 of the EAR), or...

  17. 15 CFR Supplement No. 2 to Part 748 - Unique Application and Submission Requirements

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... tools, dimensional inspection machines, direct numerical control systems, specially designed assemblies... Commerce Control List (§ 774.1 of the EAR)—see Category 5 Part 1 Notes 1 and 2 and Part 2 Note 1. License... containing computers to destinations in Country Group D:1 (See supplement No. 1 to part 740 of the EAR), or...

  18. 21 CFR 1306.25 - Transfer between pharmacies of prescription information for Schedules III, IV, and V controlled...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...: (1) The transfer must be communicated directly between two licensed pharmacists. (2) The transferring pharmacist must do the following: (i) Write the word “VOID” on the face of the invalidated prescription; for... registration number of the pharmacy to which it was transferred and the name of the pharmacist receiving the...

  19. 21 CFR 1306.25 - Transfer between pharmacies of prescription information for Schedules III, IV, and V controlled...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...: (1) The transfer must be communicated directly between two licensed pharmacists. (2) The transferring pharmacist must do the following: (i) Write the word “VOID” on the face of the invalidated prescription; for... registration number of the pharmacy to which it was transferred and the name of the pharmacist receiving the...

  20. 21 CFR 1306.25 - Transfer between pharmacies of prescription information for Schedules III, IV, and V controlled...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...: (1) The transfer must be communicated directly between two licensed pharmacists. (2) The transferring pharmacist must do the following: (i) Write the word “VOID” on the face of the invalidated prescription; for... registration number of the pharmacy to which it was transferred and the name of the pharmacist receiving the...

  1. 21 CFR 1306.25 - Transfer between pharmacies of prescription information for Schedules III, IV, and V controlled...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...: (1) The transfer must be communicated directly between two licensed pharmacists. (2) The transferring pharmacist must do the following: (i) Write the word “VOID” on the face of the invalidated prescription; for... registration number of the pharmacy to which it was transferred and the name of the pharmacist receiving the...

  2. A National Study Predicting Licensed Social Workers' Levels of Political Participation: The Role of Resources, Psychological Engagement, and Recruitment Networks

    ERIC Educational Resources Information Center

    Ritter, Jessica A.

    2008-01-01

    The social work literature is replete with studies evaluating social workers' direct practice interventions, but strikingly few have assessed how well social workers are faring in the political arena. This study tests a major theoretical model, the civic voluntarism model, developed to explain why some citizens become involved in politics, whereas…

  3. 28 CFR 25.9 - Retention and destruction of records in the system.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... in accordance with established policy. (b) The FBI will maintain an automated NICS Audit Log of all... may be accessed directly only by the FBI and only for the purpose of conducting audits of the use and... license number of the FFL and the proposed date of inspection of the named FFL by ATF, the FBI may extract...

  4. 28 CFR 25.9 - Retention and destruction of records in the system.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... in accordance with established policy. (b) The FBI will maintain an automated NICS Audit Log of all... may be accessed directly only by the FBI and only for the purpose of conducting audits of the use and... license number of the FFL and the proposed date of inspection of the named FFL by ATF, the FBI may extract...

  5. 28 CFR 25.9 - Retention and destruction of records in the system.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... in accordance with established policy. (b) The FBI will maintain an automated NICS Audit Log of all... may be accessed directly only by the FBI and only for the purpose of conducting audits of the use and... license number of the FFL and the proposed date of inspection of the named FFL by ATF, the FBI may extract...

  6. 28 CFR 25.9 - Retention and destruction of records in the system.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... in accordance with established policy. (b) The FBI will maintain an automated NICS Audit Log of all... may be accessed directly only by the FBI and only for the purpose of conducting audits of the use and... license number of the FFL and the proposed date of inspection of the named FFL by ATF, the FBI may extract...

  7. An Investigation of the effectiveness of the Virginia Habitual Offender Act : a study conducted by the Virginia Transportation Research Council for the Advisory Committee to the Commission on VASAP : final report.

    DOT National Transportation Integrated Search

    1993-01-01

    In 1968, Virginia passed the Habitual Offender Act (the Act), one of the first laws in the United States directed at motorists who repeatedly violate traffic laws. Persons adjudicated as habitual offenders are subject to long-term license revocation,...

  8. 31 CFR 500.554 - Gifts of North Korean, North Vietnamese, Cambodian, or South Vietnamese origin.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Korea, North Viet-Nam, Cambodia, or South Viet-Nam. (b) Specific licenses are issued for the importation directly from North Korea, North Viet-Nam, Cambodia, or South Viet-Nam: (1) Of goods which are claimed by... acquired in North Korea, North Viet-Nam, Cambodia, or South Viet-Nam as a bona fide gift, subject to the...

  9. 47 CFR 25.146 - Licensing and operating rules for the non-geostationary satellite orbit Fixed-Satellite Service...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...-density, in the space-to-Earth direction, (EPFD down) limits. (i) Provide a set of power flux-density (PFD) masks, on the surface of the Earth, for each space station in the NGSO FSS system. The PFD masks shall.... (2) Single-entry additional operational equivalent power flux-density, in the space-to-Earth...

  10. State Policy as an Influence on the Participation of Young Children with Medical Needs in Childcare

    ERIC Educational Resources Information Center

    Bruder, Mary Beth; Fink, Dale Borman

    2004-01-01

    The authors collected data from 48 states and the District of Columbia regarding state policies that affect the participation of children with medical needs in licensed childcare. They began with a more narrowly focused agenda of identifying policies affecting children with medically complex needs, but because few regulations are directed to this…

  11. 76 FR 59391 - Notice of Availability of Government-Owned Inventions; Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-26

    ... Issued 4/12/2011//U.S. Patent No. 7,926,275: Closed Brayton Cycle Direct Contact Reactor/Storage Tank... With Precursor Bubble Issued 4/19/2011//U.S. Patent No. 7,929,375: Method and Apparatus for Improved...: Hydrogen Generator Apparatus for an Underwater Vehicle Issued 5/10/2011//U.S. Patent No. 7,940,602...

  12. Freedom of the Press in Europe, 1815-1914. Journalism Monographs Number Eighty.

    ERIC Educational Resources Information Center

    Goldstein, Robert J.

    In 19th century Europe, the dominant classes detested the idea of a free press, seeing it as a middle and lower class weapon. Although repression of the press in Europe existed long before the 19th century, at this time techniques of press repression fell into two major categories: (1) direct--licensing, prior censorship, and post-publication…

  13. [Concepts in anticoagulant therapy - past, present, and future].

    PubMed

    Graf, L

    2012-11-01

    The understanding of the clotting system emerged in parallel to the development of anticoagulants. In contrast to vitamin K-antagonists and heparins that where discovered by chance, new anticoagulants have been systematically designed to specifically inhibit single clotting factors. Both clotting factors Xa (FXa) and thrombin play a crucial role within the new cell-based model of hemostasis. Thus it is obvious that FXa and thrombin turned out to be ideal targets for anticoagulation. The proof of the concept of selective inhibition of thrombin and FXa has been provided by hirudin and fondaparinux, respectively. By now, a whole group of new oral anticoagulants has been licensed: the direct FXa-inhibitors rivaroxaban, apixaban, and edoxaban as well as the direct thrombin dabigatran etexilate. Furthermore, a bundle of FXa- and thrombin-inhibitors that differ from the so far licensed products mainly in pharmacokinetics are in an advanced phase of development. A further innovative concept of anticoagulation that entered its clinical phase of development is the inhibition of factor VIII. Other new concepts such as inhibition of initiation of coagulation by blocking factor VIIa, inhibition of contact factor XII, or inhibition of factor IX are in an early phase of development.

  14. Microscopic analysis and simulation of check-mark stain on the galvanized steel strip

    NASA Astrophysics Data System (ADS)

    So, Hongyun; Yoon, Hyun Gi; Chung, Myung Kyoon

    2010-11-01

    When galvanized steel strip is produced through a continuous hot-dip galvanizing process, the thickness of adhered zinc film is controlled by plane impinging air gas jet referred to as "air-knife system". In such a gas-jet wiping process, stain of check-mark or sag line shape frequently appears. The check-mark defect is caused by non-uniform zinc coating and the oblique patterns such as "W", "V" or "X" on the coated surface. The present paper presents a cause and analysis of the check-mark formation and a numerical simulation of sag lines by using the numerical data produced by Large Eddy Simulation (LES) of the three-dimensional compressible turbulent flow field around the air-knife system. It was found that there is alternating plane-wise vortices near the impinging stagnation region and such alternating vortices move almost periodically to the right and to the left sides on the stagnation line due to the jet flow instability. Meanwhile, in order to simulate the check-mark formation, a novel perturbation model has been developed to predict the variation of coating thickness along the transverse direction. Finally, the three-dimensional zinc coating surface was obtained by the present perturbation model. It was found that the sag line formation is determined by the combination of the instantaneous coating thickness distribution along the transverse direction near the stagnation line and the feed speed of the steel strip.

  15. Directional detector of gamma rays

    DOEpatents

    Cox, Samson A.; Levert, Francis E.

    1979-01-01

    A directional detector of gamma rays comprises a strip of an electrical cuctor of high atomic number backed with a strip of a second electrical conductor of low atomic number. These elements are enclosed within an electrical conductor that establishes an electrical ground, maintains a vacuum enclosure and screens out low-energy gamma rays. The detector exhibits a directional sensitivity marked by an increased output in the favored direction by a factor of ten over the output in the unfavored direction.

  16. 10 CFR 40.20 - Types of licenses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Types of licenses. 40.20 Section 40.20 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF SOURCE MATERIAL General Licenses § 40.20 Types of licenses. (a) Licenses for source material and byproduct material are of two types: general and specific. Licenses for...

  17. 10 CFR 50.80 - Transfer of licenses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Transfer of licenses. 50.80 Section 50.80 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION AND UTILIZATION FACILITIES Transfers of Licenses-Creditors' Rights-Surrender of Licenses § 50.80 Transfer of licenses. (a) No license for a production or...

  18. 10 CFR 50.80 - Transfer of licenses.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Transfer of licenses. 50.80 Section 50.80 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION AND UTILIZATION FACILITIES Transfers of Licenses-Creditors' Rights-Surrender of Licenses § 50.80 Transfer of licenses. (a) No license for a production or...

  19. 10 CFR 55.51 - Issuance of licenses.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Issuance of licenses. 55.51 Section 55.51 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Licenses § 55.51 Issuance of licenses. Operator and senior operator licenses. If the Commission determines that an applicant for an operator license or a...

  20. 10 CFR 55.53 - Conditions of licenses.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Conditions of licenses. 55.53 Section 55.53 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Licenses § 55.53 Conditions of licenses. Each license contains and is subject to the following conditions whether stated in the license or not: (a) Neither the...

  1. Influence of Social Class Perceptions on Attributions among Mental Health Practitioners

    PubMed Central

    Thomposon, Mindi; Diestelmann, Jacob; Cole, Odessa; Keller, Abiola; Minami, Takuya

    2018-01-01

    Objective A vignette-based study assessed the influence of social class attributions toward a hypothetical client’s difficulty. Method 188 licensed mental health professionals who were recruited through professional listservs completed an online survey after reviewing one of two versions of a vignette describing a hypothetical client that varied based on social class cues. Results As expected, this sample of licensed mental health practitioners detected social class differences based on the descriptors of the hypothetical client across the two vignettes. These perceived social class differences, however, did not impact participants’ attributions toward the client for causing or solving her problems, level of GAF score ascribed to the client, or willingness to work with the client. Conclusions There was no evidence that participants differentially ascribed attributions based on social class. Implications and directions for future research are provided. PMID:24499284

  2. Supporting drivers in forming correct expectations about transitions between rural road categories.

    PubMed

    Stelling-Konczak, Agnieszka; Aarts, Letty; Duivenvoorden, Kirsten; Goldenbeld, Charles

    2011-01-01

    In order to support drivers in forming the right expectations on the road, road categories are being made recognisable and predictable in the Netherlands. The present study investigated which of the selected road layouts can make rural road categories most recognisable for road users, especially in transitions from one road category to another. A second objective was to study whether explicit information could contribute to a better recognisability of transitions. The experiment was performed with a series of photographs showing sections of two road categories with an intersection in between. The road layout of road categories varied in markings and separation of driving direction (within-subjects factor). Informed and non-informed participants (between-subjects factor) had to indicate their expectations regarding speed limit and access restriction of each road section, before and after a transition. The results show that for transitions between distributor and through roads, the physicality of separation of driving direction is a better distinctive characteristic than the currently used edge marking. The green centre marking on through roads also enhances recognisability, but only with additional information. As far as transitions between distributor and access roads are concerned, the results demonstrate that this type of transitions is better recognised when no markings on access roads are present. Physical separation of driving directions on distributor roads also improves recognisability, although this layout is associated with higher speed limits. Providing explicit information has in general a positive effect on the reconisability of transitions. Implications are discussed in the light of potential safety effects. Copyright © 2010 Elsevier Ltd. All rights reserved.

  3. Effects of water temperature on the mortality of field-collected fish marked with fluorescent pigment

    USGS Publications Warehouse

    Holland Bartels, L. E.; Dewey, M.R.; Zigler, S.J.

    1989-01-01

    The cumulative effects of collection, handling, and marking with fluorescent pigment on the mortality of adult minnows, young-of-the-year centrarchids, and large centrarchids and percids was determined at five water temperatures (10-20.6 degree C) in field trials. There have been few field trials of this type. The mortality of centrarchids and percids was directly related to temperature and decreased noticeably when the temperature was below 19.5 degree C. The mortality of minnows decreased somewhat as river temperatures cooled but was always at least 50%. Variation was high in the temperature-related patterns of mortality in different taxa and sizes of fish. This variation complicates the accuracy and usefulness of pigment in marking field-collected fish for mark-recapture studies in warmwater systems.

  4. The Optimal Licensing Contract in a Differentiated Stackelberg Model

    PubMed Central

    Hong, Xianpei; Yang, Lijun; Zhang, Huaige; Zhao, Dan

    2014-01-01

    This paper extends the work of Wang (2002) by considering a differentiated Stackelberg model, when the leader firm is an inside innovator and licenses its new technology by three options, that is, fixed-fee licensing, royalty licensing, and two-part tariff licensing. The main contributions and conclusions of this paper are threefold. First of all, this paper derives a very different result from Wang (2002). We show that, with a nondrastic innovation, royalty licensing is always better than fixed-fee licensing for the innovator; with a drastic innovation, royalty licensing is superior to fixed-fee licensing for small values of substitution coefficient d; however when d becomes closer to 1, neither fee nor royalty licensing will occur. Secondly, this paper shows that the innovator is always better off in case of two-part tariff licensing than fixed-fee licensing no matter what the innovation size is. Thirdly, the innovator always prefers to license its nondrastic innovation by means of a two-part tariff instead of licensing by means of a royalty; however, with a drastic innovation, the optimal licensing strategy can be either a two-part tariff or a royalty, depending upon the differentiation of the goods. PMID:24683342

  5. The optimal licensing contract in a differentiated Stackelberg model.

    PubMed

    Hong, Xianpei; Yang, Lijun; Zhang, Huaige; Zhao, Dan

    2014-01-01

    This paper extends the work of Wang (2002) by considering a differentiated Stackelberg model, when the leader firm is an inside innovator and licenses its new technology by three options, that is, fixed-fee licensing, royalty licensing, and two-part tariff licensing. The main contributions and conclusions of this paper are threefold. First of all, this paper derives a very different result from Wang (2002). We show that, with a nondrastic innovation, royalty licensing is always better than fixed-fee licensing for the innovator; with a drastic innovation, royalty licensing is superior to fixed-fee licensing for small values of substitution coefficient d; however when d becomes closer to 1, neither fee nor royalty licensing will occur. Secondly, this paper shows that the innovator is always better off in case of two-part tariff licensing than fixed-fee licensing no matter what the innovation size is. Thirdly, the innovator always prefers to license its nondrastic innovation by means of a two-part tariff instead of licensing by means of a royalty; however, with a drastic innovation, the optimal licensing strategy can be either a two-part tariff or a royalty, depending upon the differentiation of the goods.

  6. Licensing Process | NREL

    Science.gov Websites

    Agreement After the company and NREL agree on license financial terms, NREL will draft a license agreement Group Licensing Guide and Sample License. 4. Negotiate License Language After a draft agreement has been created, NREL can tailor many of the license provisions to ensure an agreement that works for all parties

  7. 76 FR 38463 - SAFE Mortgage Licensing Act: Minimum Licensing Standards and Oversight Responsibilities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-30

    ... Parts 30 and 3400 SAFE Mortgage Licensing Act: Minimum Licensing Standards and Oversight... No. FR-5271-F-03] RIN 2502-A170 SAFE Mortgage Licensing Act: Minimum Licensing Standards and... pursuant to the Secure and Fair Enforcement Mortgage Licensing Act of 2008 (SAFE Act or Act), to ensure...

  8. Creative Commons licenses and the non-commercial condition: Implications for the re-use of biodiversity information

    PubMed Central

    Hagedorn, Gregor; Mietchen, Daniel; Morris, Robert A.; Agosti, Donat; Penev, Lyubomir; Berendsohn, Walter G.; Hobern, Donald

    2011-01-01

    Abstract The Creative Commons (CC) licenses are a suite of copyright-based licenses defining terms for the distribution and re-use of creative works. CC provides licenses for different use cases and includes open content licenses such as the Attribution license (CC BY, used by many Open Access scientific publishers) and the Attribution Share Alike license (CC BY-SA, used by Wikipedia, for example). However, the license suite also contains non-free and non-open licenses like those containing a “non-commercial” (NC) condition. Although many people identify “non-commercial” with “non-profit”, detailed analysis reveals that significant differences exist and that the license may impose some unexpected re-use limitations on works thus licensed. After providing background information on the concepts of Creative Commons licenses in general, this contribution focuses on the NC condition, its advantages, disadvantages and appropriate scope. Specifically, it contributes material towards a risk analysis for potential re-users of NC-licensed works. PMID:22207810

  9. Creative Commons licenses and the non-commercial condition: Implications for the re-use of biodiversity information.

    PubMed

    Hagedorn, Gregor; Mietchen, Daniel; Morris, Robert A; Agosti, Donat; Penev, Lyubomir; Berendsohn, Walter G; Hobern, Donald

    2011-01-01

    The Creative Commons (CC) licenses are a suite of copyright-based licenses defining terms for the distribution and re-use of creative works. CC provides licenses for different use cases and includes open content licenses such as the Attribution license (CC BY, used by many Open Access scientific publishers) and the Attribution Share Alike license (CC BY-SA, used by Wikipedia, for example). However, the license suite also contains non-free and non-open licenses like those containing a "non-commercial" (NC) condition. Although many people identify "non-commercial" with "non-profit", detailed analysis reveals that significant differences exist and that the license may impose some unexpected re-use limitations on works thus licensed. After providing background information on the concepts of Creative Commons licenses in general, this contribution focuses on the NC condition, its advantages, disadvantages and appropriate scope. Specifically, it contributes material towards a risk analysis for potential re-users of NC-licensed works.

  10. Super-Compact Laser

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Microcosm, Inc. produced the portable Farfield-2 laser for field applications that require high power pulsed illumination. The compact design was conceived through research at Goddard Space Flight Center on laser instruments for space missions to carry out geoscience studies of Earth. An exclusive license to the key NASA patent for the compact laser design was assigned to Microcosm. The FarField-2 is ideal for field applications, has low power consumption, does not need water cooling or gas supplies, and produces nearly ideal beam quality. The properties of the laser also make it effective over long distances, which is one reason why NASA developed the technology for laser altimeters that can be toted aboard spacecraft. Applications for the FarField-2 include medicine, biology, and materials science and processing, as well as diamond marking, semiconductor line-cutting, chromosome surgery, and fluorescence microscopy.

  11. KSC-2011-1217

    NASA Image and Video Library

    2011-01-27

    CAPE CANAVERAL, Fla. -- Kennedy Space Center Director and former astronaut Bob Cabana answers media questions during a Day of Remembrance wreath laying ceremony at the Space Mirror Memorial at the Kennedy Space Center Visitor Complex in Florida. The ceremony honors members of the NASA family who lost their lives while furthering the cause of exploration and discovery. The memorial displays the names of 24 United States astronauts, including the crew members of space shuttles Columbia and Challenger, Apollo 1, and those who died in training and commercial airplane accidents. The memorial is a project of the Astronauts Memorial Foundation and was paid for by Florida residents who purchased special Challenger mission automobile license plates. 2011 marks the 25th anniversary of the loss of Challenger, which broke apart over the Atlantic Ocean 73 seconds into flight on Jan. 28, 1986. Photo credit: NASA/Kim Shiflett

  12. KSC-2011-1213

    NASA Image and Video Library

    2011-01-27

    CAPE CANAVERAL, Fla. -- President and C.E.O. of The Astronauts Memorial Foundation Stephen Feldman displays a single yellow rose near the Space Mirror Memorial at the Kennedy Space Center Visitor Complex in Florida during a Day of Remembrance ceremony to honor members of the NASA family who lost their lives while furthering the cause of exploration and discovery. The memorial honors 24 United States astronauts, including the crew members of space shuttles Columbia and Challenger, Apollo 1, and those who died in training and commercial airplane accidents. The memorial is a project of the Astronauts Memorial Foundation and was paid for by Florida residents who purchased special Challenger mission automobile license plates. 2011 marks the 25th anniversary of the loss of Challenger, which broke apart over the Atlantic Ocean 73 seconds into flight on Jan. 28, 1986. Photo credit: NASA/Kim Shiflett

  13. British firms mark progress off Viet Nam

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1992-11-23

    British companies are making more inroads in exploring for oil and gas off Viet Nam. British Gas plc won a 25 year production sharing contract for a license off southern Viet Nam in the South China Sea. Meantime, London independent Lasmo plc started seismic surveys on the block adjoining the British Gas block. Separately, Thailand and Viet Nam have reached agreement to jointly explore for and develop oil and gas found in waters claimed by both countries. Plans call for the two countries to draw up joint development plans covering oil and gas resources in the southeastern fringe of themore » Gulf of Thailand. Bangkok officials say they would have preferred to delineate maritime boundaries with Hanoi, but opted for the joint development accord, noting that Thailand and Malaysia had taken 12 years to resolve a similar dispute.« less

  14. Safeguarding Porpoises

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The NetMark 1000 by the Dukane Corporation, used to safeguard porpoises from net entanglement, employs technology developed in the late 1960s by NASA engineers at the Langley Research Center. It is based on an underwater location aid, able to withstand high impact, then emit multidirectional signals for hours on end, originally used in the retrieval of NASA payloads following watery touch-downs on Earth. Dukane and Burnett Electronics later obtained a license from NASA, further improving on the beacon design. In a large scale experiment off the coast of New Hampshire in autumn of 1994, it was found that the use of acoustic alarms appears to hold considerable promise in reducing the number of harbor porpoises killed in the sink gill nets in the Gulf of Maine. Dukane has sold well over 100,000 units. Applications of the pinger are also expanding to other animal species.

  15. Marking emergency exits and evacuation routes with sound beacons utilizing the precedence effect

    NASA Astrophysics Data System (ADS)

    van Wijngaarden, Sander J.; Bronkhorst, Adelbert W.; Boer, Louis C.

    2004-05-01

    Sound beacons can be extremely useful during emergency evacuations, especially when vision is obscured by smoke. When exits are marked with suitable sound sources, people can find these using only their capacity for directional hearing. Unfortunately, unless very explicit instructions were given, sound beacons currently commercially available (based on modulated noise) led to disappointing results during an evacuation experiment in a traffic tunnel. Only 19% out of 65 subjects were able to find an exit by ear. A signal designed to be more self-explanatory and less hostile-sounding (alternating chime signal and spoken message ``exit here'') increased the success rate to 86%. In a more complex environment-a mock-up of a ship's interior-routes to the exit were marked using multiple beacons. By applying carefully designed time delays between successive beacons, the direction of the route was marked, utilizing the precedence effect. Out of 34 subjects, 71% correctly followed the evacuation route by ear (compared to 24% for a noise signal as used in commercially available beacons). Even when subjects were forced to make a worst-case left-right decision at a T-junction, between two beacons differing only in arrival of the first wave front, 77% made the right decision.

  16. Direct evidence of hybodont shark predation on Late Jurassic ammonites

    NASA Astrophysics Data System (ADS)

    Vullo, Romain

    2011-06-01

    Sharks are known to have been ammonoid predators, as indicated by analysis of bite marks or coprolite contents. However, body fossil associations attesting to this predator-prey relationship have never been described so far. Here, I report a unique finding from the Late Jurassic of western France: a complete specimen of the Kimmeridgian ammonite Orthaspidoceras bearing one tooth of the hybodont shark Planohybodus. Some possible tooth puncture marks are also observed. This is the first direct evidence of such a trophic link between these two major Mesozoic groups, allowing an accurate identification of both organisms. Although Planohybodus displays a tearing-type dentition generally assumed to have been especially adapted for large unshelled prey, our discovery clearly shows that this shark was also able to attack robust ammonites such as aspidoceratids. The direct evidence presented here provides new insights into the Mesozoic marine ecosystem food webs.

  17. Influence of Shear Stiffness Degradation on Crack Paths in Uni-Directional Composite Laminates

    NASA Technical Reports Server (NTRS)

    Satyanarayana, Arunkumar; Bogert, Phil B.

    2017-01-01

    Influence of shear stiffness degradation in an element, due to damage, on crack paths in uni-directional laminates has been demonstrated. A new shear stiffness degradation approach to improve crack path prediction has been developed and implemented in an ABAQUS/Explicit frame work using VUMAT. Three progressive failure analysis models, built-in ABAQUS (TradeMark), original COmplete STress Reduction (COSTR) and the modified COSTR damage models have been utilized in this study to simulate crack paths in five unidirectional notched laminates, 15deg, 30deg, 45deg, 60deg and 75deg under uniaxial tension load. Results such as crack paths and load vs. edge displacement curves are documented in this report. Modified COSTR damage model shows better accuracy in predicting crack paths in all the uni-directional laminates compared to the ABAQUS (TradeMark) and the original COSTR damage models.

  18. 47 CFR 13.9 - Eligibility and application for new license or endorsement.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Operator License, Marine Radio Operator Permit, Radiotelegraph Operator License, Ship Radar Endorsement, Six Months Service Endorsement, GMDSS Radio Operator's License, Restricted GMDSS Radio Operator's... Radiotelephone Operator License, Marine Radio Operator Permit, Radiotelegraph Operator License, Ship Radar...

  19. 47 CFR 13.9 - Eligibility and application for new license or endorsement.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Operator License, Marine Radio Operator Permit, Radiotelegraph Operator License, Ship Radar Endorsement, Six Months Service Endorsement, GMDSS Radio Operator's License, Restricted GMDSS Radio Operator's... Radiotelephone Operator License, Marine Radio Operator Permit, Radiotelegraph Operator License, Ship Radar...

  20. Perception survey on the introduction of clinical performance examination as part of the national nursing licensing examination in Korea.

    PubMed

    Shin, Su Jin; Kim, Yeong Kyeong; Suh, Soon-Rim; Jung, Duk Yoo; Kim, Yunju; Yim, Mi Kyoung

    2017-01-01

    The purpose of this study was to analyze opinions about the action plan for implementation of clinical performance exam as part of the national nursing licensing examination and presents the expected effects of the performance exam and aspects to consider regarding its implementation. This study used a mixed-methods design. Quantitative data were collected by a questionnaire survey, while qualitative data were collected by focus group interviews with experts. The survey targeted 200 nursing professors and clinical nurses with more than 5 years of work experience, and the focus group interviews were conducted with 28 of professors, clinical instructors, and nurses at hospitals. First, nursing professors and clinical specialists agreed that the current written tests have limitations in evaluating examinees' ability, and that the introduction of a clinical performance exam will yield positive results. Clinical performance exam is necessary to evaluate and improve nurses' work ability, which means that the implementation of a performance exam is advisable if its credibility and validity can be verified. Second, most respondents chose direct performance exams using simulators or standardized patients as the most suitable format of the test. In conclusion, the current national nursing licensing exam is somewhat limited in its ability to identify competent nurses. Thus, the time has come for us to seriously consider the introduction of a performance exam. The prerequisites for successfully implementing clinical performance exam as part of the national nursing licensing exam are a professional training process and forming a consortium to standardize practical training.

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