28 CFR 69.205 - Professional and technical services.

Code of Federal Regulations, 2010 CFR

2010-07-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... applying their professional or technical expertise and unless the advice or analysis is rendered directly... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Professional and technical services. 69...

45 CFR 1230.205 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-10-01

... section, “professional and technical services” shall be limited to advice and analysis directly applying... this section unless they provide advice and analysis directly applying their professional or technical... 45 Public Welfare 4 2011-10-01 2011-10-01 false Professional and technical services. 1230.205...

41 CFR 105-69.205 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-01-01

... section, “professional and technical services” shall be limited to advice and analysis directly applying... this section unless they provide advice and analysis directly applying their professional or technical... technical services. 105-69.205 Section 105-69.205 Public Contracts and Property Management Federal Property...

32 CFR 28.205 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., “professional and technical services” shall be limited to advice and analysis directly applying any professional... provide advice and analysis directly applying their professional or technical expertise and unless the... 32 National Defense 1 2011-07-01 2011-07-01 false Professional and technical services. 28.205...

41 CFR 105-69.300 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-01-01

..., “professional and technical services” shall be limited to advice and analysis directly applying any professional... provide advice and analysis directly applying their professional or technical expertise and unless the... technical services. 105-69.300 Section 105-69.300 Public Contracts and Property Management Federal Property...

The General Revenue Effects of the California Property Tax Limitation Amendment

ERIC Educational Resources Information Center

Shapiro, Perry; Morgan W. Douglas

1978-01-01

Develops a general revenue model that incorporates the feedback and interaction between major federal, state, and local revenue sources. The model is applied to California for the 1965-75 period and the results are applied to an analysis of the property tax limitation initiative. Available from Stanley J. Bowers, Executive Director, NTA-TIA, 21…

15 CFR 28.205 - Professional and technical services.

Code of Federal Regulations, 2010 CFR

2010-01-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... applying their professional or technical expertise and unless the advice or analysis is rendered directly... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Professional and technical services...

31 CFR 21.205 - Professional and technical services.

Code of Federal Regulations, 2010 CFR

2010-07-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... applying their professional or technical expertise and unless the advice or analysis is rendered directly... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Professional and technical services...

40 CFR 34.205 - Professional and technical services.

Code of Federal Regulations, 2010 CFR

2010-07-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... applying their professional or technical expertise and unless the advice or analysis is rendered directly... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Professional and technical services. 34...

14 CFR 1271.205 - Professional and technical services.

Code of Federal Regulations, 2010 CFR

2010-01-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... applying their professional or technical expertise and unless the advice or analysis is rendered directly... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Professional and technical services. 1271...

22 CFR 712.205 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-04-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... applying their professional or technical expertise and unless the advice or analysis is rendered directly... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Professional and technical services. 712.205...

45 CFR 604.205 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-10-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... applying their professional or technical expertise and unless the advice or analysis is rendered directly... 45 Public Welfare 3 2011-10-01 2011-10-01 false Professional and technical services. 604.205...

40 CFR 34.205 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-07-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... applying their professional or technical expertise and unless the advice or analysis is rendered directly... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Professional and technical services. 34...

Bayesian approach for counting experiment statistics applied to a neutrino point source analysis

NASA Astrophysics Data System (ADS)

Bose, D.; Brayeur, L.; Casier, M.; de Vries, K. D.; Golup, G.; van Eijndhoven, N.

2013-12-01

In this paper we present a model independent analysis method following Bayesian statistics to analyse data from a generic counting experiment and apply it to the search for neutrinos from point sources. We discuss a test statistic defined following a Bayesian framework that will be used in the search for a signal. In case no signal is found, we derive an upper limit without the introduction of approximations. The Bayesian approach allows us to obtain the full probability density function for both the background and the signal rate. As such, we have direct access to any signal upper limit. The upper limit derivation directly compares with a frequentist approach and is robust in the case of low-counting observations. Furthermore, it allows also to account for previous upper limits obtained by other analyses via the concept of prior information without the need of the ad hoc application of trial factors. To investigate the validity of the presented Bayesian approach, we have applied this method to the public IceCube 40-string configuration data for 10 nearby blazars and we have obtained a flux upper limit, which is in agreement with the upper limits determined via a frequentist approach. Furthermore, the upper limit obtained compares well with the previously published result of IceCube, using the same data set.

Applied Behavior Analysis: Beyond Discrete Trial Teaching

ERIC Educational Resources Information Center

Steege, Mark W.; Mace, F. Charles; Perry, Lora; Longenecker, Harold

2007-01-01

We discuss the problem of autism-specific special education programs representing themselves as Applied Behavior Analysis (ABA) programs when the only ABA intervention employed is Discrete Trial Teaching (DTT), and often for limited portions of the school day. Although DTT has many advantages to recommend its use, it is not well suited to teach…

Background Information and User’s Guide for MIL-F-9490

DTIC Science & Technology

1975-01-01

requirements, although different analysis results will apply to each requirement. Basic differences between the two realibility requirements are: MIL-F-8785B...provides the rationale for establishing such limits. The specific risk analysis comprises the same data which formed the average risk analysis , except...statistical analysis will be based on statistical data taken using limited exposure Limes of components and equipment. The exposure times and resulting

Heisenberg principle applied to the analysis of speckle interferometry fringes

NASA Astrophysics Data System (ADS)

Sciammarella, C. A.; Sciammarella, F. M.

2003-11-01

Optical techniques that are used to measure displacements utilize a carrier. When a load is applied the displacement field modulates the carrier. The accuracy of the information that can be recovered from the modulated carrier is limited by a number of factors. In this paper, these factors are analyzed and conclusions concerning the limitations in information recovery are illustrated with examples taken from experimental data.

Non-linear programming in shakedown analysis with plasticity and friction

NASA Astrophysics Data System (ADS)

Spagnoli, A.; Terzano, M.; Barber, J. R.; Klarbring, A.

2017-07-01

Complete frictional contacts, when subjected to cyclic loading, may sometimes develop a favourable situation where slip ceases after a few cycles, an occurrence commonly known as frictional shakedown. Its resemblance to shakedown in plasticity has prompted scholars to apply direct methods, derived from the classical theorems of limit analysis, in order to assess a safe limit to the external loads applied on the system. In circumstances where zones of plastic deformation develop in the material (e.g., because of the large stress concentrations near the sharp edges of a complete contact), it is reasonable to expect an effect of mutual interaction of frictional slip and plastic strains on the load limit below which the global behaviour is non dissipative, i.e., both slip and plastic strains go to zero after some dissipative load cycles. In this paper, shakedown of general two-dimensional discrete systems, involving both friction and plasticity, is discussed and the shakedown limit load is calculated using a non-linear programming algorithm based on the static theorem of limit analysis. An illustrative example related to an elastic-plastic solid containing a frictional crack is provided.

Laser-induced fluorescence spectroscopy for improved chemical analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gelbwachs, J.A.

1983-09-01

This report summarizes the progress achieved over the past five years in the laser-induced fluorescence spectroscopy (LIFS) for improved chemical analysis program. Our initial efforts yielded significantly lower detection limits for trace elemental analysis by the use of both cw and pulsed laser excitations. New methods of LIFS were developed that were shown to overcome many of the traditional limitations to LIFS techniques. LIFS methods have been applied to yield fundamental scientific data that further the understanding of forces between atoms and other atoms and molecules. In recent work, two-photon ionization was combined with LIFS and applied, for the firstmore » time, to the study of energy transfer in ions.« less

UK Parents' Beliefs about Applied Behaviour Analysis as an Approach to Autism Education

ERIC Educational Resources Information Center

Denne, Louise D.; Hastings, Richard P.; Hughes, J. Carl

2017-01-01

Research into factors underlying the dissemination of evidence-based practice is limited within the field of Applied Behaviour Analysis (ABA). This is pertinent, particularly in the UK where national policies and guidelines do not reflect the emerging ABA evidence base, or policies and practices elsewhere. Theories of evidence-based practice in…

14 CFR 35.37 - Fatigue limits and evaluation.

Code of Federal Regulations, 2014 CFR

2014-01-01

... AIRWORTHINESS STANDARDS: PROPELLERS Tests and Inspections § 35.37 Fatigue limits and evaluation. This section does not apply to fixed-pitch wood propellers of conventional design. (a) Fatigue limits must be established by tests, or analysis based on tests, for propeller: (1) Hubs. (2) Blades. (3) Blade retention...

14 CFR 35.37 - Fatigue limits and evaluation.

Code of Federal Regulations, 2012 CFR

2012-01-01

... AIRWORTHINESS STANDARDS: PROPELLERS Tests and Inspections § 35.37 Fatigue limits and evaluation. This section does not apply to fixed-pitch wood propellers of conventional design. (a) Fatigue limits must be established by tests, or analysis based on tests, for propeller: (1) Hubs. (2) Blades. (3) Blade retention...

14 CFR 35.37 - Fatigue limits and evaluation.

Code of Federal Regulations, 2013 CFR

2013-01-01

... AIRWORTHINESS STANDARDS: PROPELLERS Tests and Inspections § 35.37 Fatigue limits and evaluation. This section does not apply to fixed-pitch wood propellers of conventional design. (a) Fatigue limits must be established by tests, or analysis based on tests, for propeller: (1) Hubs. (2) Blades. (3) Blade retention...

14 CFR 35.37 - Fatigue limits and evaluation.

Code of Federal Regulations, 2011 CFR

2011-01-01

... AIRWORTHINESS STANDARDS: PROPELLERS Tests and Inspections § 35.37 Fatigue limits and evaluation. This section does not apply to fixed-pitch wood propellers of conventional design. (a) Fatigue limits must be established by tests, or analysis based on tests, for propeller: (1) Hubs. (2) Blades. (3) Blade retention...

Laser-induced-fluorescence spectroscopy for improved chemical analysis. Progress report, 1978-1983

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gelbwachs, J.A.

1983-09-01

This report summarizes the progress achieved over the past five years in the laser-induced fluorescence spectroscopy (LIFS) for improved chemical analysis program. Our initial efforts yielded significantly lower detection limits for trace elemental analysis by the use of both cw and pulsed laser excitations. New methods of LIFS were developed that were shown to overcome many of the traditional limitations to LIFS techniques. LIFS methods have been applied to yield fundamental scientific data that further the understanding of forces between atoms and other atoms and molecules. In recent work, two-photon ionization was combined with LIFS and applied, for the firstmore » time, to the study of energy transfer in ions.« less

Laser-induced-fluorescence spectroscopy for improved chemical analysis. Progress report, 1978-1983

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gelbwachs, J.A.

1983-09-01

This report summarizes the progress achieved over the past five years in the laser-induced-fluorescence spectroscopy (LIFS) for improved chemical-analysis program. Our initial efforts yielded significantly lower detection limits for trace elemental analysis by the use of both cw and pulsed-laser excitations. New methods of LIFS were developed that were shown to overcome many of the traditional limitations to LIFS techniques. LIFS methods have been applied to yield fundamental scientific data that further the understanding of forces between atoms and other atoms and molecules. In recent work, two-photon ionization was combined with LIFS and applied, for the first time, to themore » study of energy transfer in ions.« less

28 CFR 69.300 - Professional and technical services.

Code of Federal Regulations, 2012 CFR

2012-07-01

... limited to advice and analysis directly applying any professional or technical discipline. For example... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

6 CFR 9.23 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-01-01

... limited to advice and analysis directly applying any professional or technical discipline. For example... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

15 CFR 28.300 - Professional and technical services.

Code of Federal Regulations, 2013 CFR

2013-01-01

... limited to advice and analysis directly applying any professional or technical discipline. For example... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

15 CFR 28.300 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-01-01

... limited to advice and analysis directly applying any professional or technical discipline. For example... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

43 CFR 18.300 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-10-01

... limited to advice and analysis directly applying any professional or technical discipline. For example... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

6 CFR 9.23 - Professional and technical services.

Code of Federal Regulations, 2014 CFR

2014-01-01

... limited to advice and analysis directly applying any professional or technical discipline. For example... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

6 CFR 9.23 - Professional and technical services.

Code of Federal Regulations, 2013 CFR

2013-01-01

... limited to advice and analysis directly applying any professional or technical discipline. For example... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

6 CFR 9.23 - Professional and technical services.

Code of Federal Regulations, 2012 CFR

2012-01-01

... limited to advice and analysis directly applying any professional or technical discipline. For example... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

15 CFR 28.300 - Professional and technical services.

Code of Federal Regulations, 2014 CFR

2014-01-01

... limited to advice and analysis directly applying any professional or technical discipline. For example... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

43 CFR 18.300 - Professional and technical services.

Code of Federal Regulations, 2013 CFR

2013-10-01

... limited to advice and analysis directly applying any professional or technical discipline. For example... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

28 CFR 69.300 - Professional and technical services.

Code of Federal Regulations, 2014 CFR

2014-07-01

... limited to advice and analysis directly applying any professional or technical discipline. For example... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

28 CFR 69.300 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-07-01

... limited to advice and analysis directly applying any professional or technical discipline. For example... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

15 CFR 28.300 - Professional and technical services.

Code of Federal Regulations, 2012 CFR

2012-01-01

... limited to advice and analysis directly applying any professional or technical discipline. For example... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

28 CFR 69.300 - Professional and technical services.

Code of Federal Regulations, 2013 CFR

2013-07-01

... limited to advice and analysis directly applying any professional or technical discipline. For example... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

43 CFR 18.205 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-10-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

28 CFR 69.205 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-07-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

6 CFR 9.15 - Professional and technical services.

Code of Federal Regulations, 2012 CFR

2012-01-01

... shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

13 CFR 146.300 - Professional and technical services.

Code of Federal Regulations, 2013 CFR

2013-01-01

... services shall be limited to advice and analysis directly applying any professional or technical discipline... influence made by an engineer providing an engineering analysis prior to the preparation or submission of a...

15 CFR 28.205 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-01-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

45 CFR 604.205 - Professional and technical services.

Code of Federal Regulations, 2013 CFR

2013-10-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

18 CFR 1315.205 - Professional and technical services.

Code of Federal Regulations, 2013 CFR

2013-04-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

18 CFR 1315.205 - Professional and technical services.

Code of Federal Regulations, 2012 CFR

2012-04-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

45 CFR 93.300 - Professional and technical services.

Code of Federal Regulations, 2013 CFR

2013-10-01

... services shall be limited to advice and analysis directly applying any professional or technical discipline... influence made by an engineer providing an engineering analysis prior to the preparation or submission of a...

45 CFR 604.205 - Professional and technical services.

Code of Federal Regulations, 2014 CFR

2014-10-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

13 CFR 146.300 - Professional and technical services.

Code of Federal Regulations, 2014 CFR

2014-01-01

... services shall be limited to advice and analysis directly applying any professional or technical discipline... influence made by an engineer providing an engineering analysis prior to the preparation or submission of a...

28 CFR 69.205 - Professional and technical services.

Code of Federal Regulations, 2012 CFR

2012-07-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

13 CFR 146.205 - Professional and technical services.

Code of Federal Regulations, 2014 CFR

2014-01-01

... shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

31 CFR 21.205 - Professional and technical services.

Code of Federal Regulations, 2013 CFR

2013-07-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

6 CFR 9.15 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-01-01

... shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

18 CFR 1315.205 - Professional and technical services.

Code of Federal Regulations, 2014 CFR

2014-04-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

22 CFR 712.205 - Professional and technical services.

Code of Federal Regulations, 2013 CFR

2013-04-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

40 CFR 34.205 - Professional and technical services.

Code of Federal Regulations, 2014 CFR

2014-07-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

28 CFR 69.205 - Professional and technical services.

Code of Federal Regulations, 2013 CFR

2013-07-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

43 CFR 18.205 - Professional and technical services.

Code of Federal Regulations, 2013 CFR

2013-10-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

22 CFR 712.205 - Professional and technical services.

Code of Federal Regulations, 2014 CFR

2014-04-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

15 CFR 28.205 - Professional and technical services.

Code of Federal Regulations, 2012 CFR

2012-01-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

40 CFR 34.205 - Professional and technical services.

Code of Federal Regulations, 2012 CFR

2012-07-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

31 CFR 21.205 - Professional and technical services.

Code of Federal Regulations, 2012 CFR

2012-07-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

45 CFR 93.300 - Professional and technical services.

Code of Federal Regulations, 2014 CFR

2014-10-01

... services shall be limited to advice and analysis directly applying any professional or technical discipline... influence made by an engineer providing an engineering analysis prior to the preparation or submission of a...

45 CFR 93.205 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-10-01

... shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

14 CFR 1271.205 - Professional and technical services.

Code of Federal Regulations, 2013 CFR

2013-01-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

45 CFR 93.300 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-10-01

... services shall be limited to advice and analysis directly applying any professional or technical discipline... influence made by an engineer providing an engineering analysis prior to the preparation or submission of a...

13 CFR 146.205 - Professional and technical services.

Code of Federal Regulations, 2012 CFR

2012-01-01

... shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

31 CFR 21.205 - Professional and technical services.

Code of Federal Regulations, 2014 CFR

2014-07-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

15 CFR 28.205 - Professional and technical services.

Code of Federal Regulations, 2014 CFR

2014-01-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

45 CFR 604.205 - Professional and technical services.

Code of Federal Regulations, 2012 CFR

2012-10-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

43 CFR 18.205 - Professional and technical services.

Code of Federal Regulations, 2014 CFR

2014-10-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

14 CFR 1271.205 - Professional and technical services.

Code of Federal Regulations, 2012 CFR

2012-01-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

6 CFR 9.15 - Professional and technical services.

Code of Federal Regulations, 2014 CFR

2014-01-01

... shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

40 CFR 34.205 - Professional and technical services.

Code of Federal Regulations, 2013 CFR

2013-07-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

15 CFR 28.205 - Professional and technical services.

Code of Federal Regulations, 2013 CFR

2013-01-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

18 CFR 1315.205 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-04-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

28 CFR 69.205 - Professional and technical services.

Code of Federal Regulations, 2014 CFR

2014-07-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

45 CFR 93.205 - Professional and technical services.

Code of Federal Regulations, 2014 CFR

2014-10-01

... shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

13 CFR 146.205 - Professional and technical services.

Code of Federal Regulations, 2013 CFR

2013-01-01

... shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

13 CFR 146.300 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-01-01

... services shall be limited to advice and analysis directly applying any professional or technical discipline... influence made by an engineer providing an engineering analysis prior to the preparation or submission of a...

6 CFR 9.15 - Professional and technical services.

Code of Federal Regulations, 2013 CFR

2013-01-01

... shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

45 CFR 93.205 - Professional and technical services.

Code of Federal Regulations, 2012 CFR

2012-10-01

... shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

22 CFR 712.205 - Professional and technical services.

Code of Federal Regulations, 2012 CFR

2012-04-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

45 CFR 93.205 - Professional and technical services.

Code of Federal Regulations, 2013 CFR

2013-10-01

... shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

45 CFR 93.300 - Professional and technical services.

Code of Federal Regulations, 2012 CFR

2012-10-01

... services shall be limited to advice and analysis directly applying any professional or technical discipline... influence made by an engineer providing an engineering analysis prior to the preparation or submission of a...

13 CFR 146.300 - Professional and technical services.

Code of Federal Regulations, 2012 CFR

2012-01-01

... services shall be limited to advice and analysis directly applying any professional or technical discipline... influence made by an engineer providing an engineering analysis prior to the preparation or submission of a...

14 CFR 1271.205 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-01-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

31 CFR 21.205 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-07-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

13 CFR 146.205 - Professional and technical services.

Code of Federal Regulations, 2011 CFR

2011-01-01

... shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

Local structure studies of materials using pair distribution function analysis

NASA Astrophysics Data System (ADS)

Peterson, Joseph W.

A collection of pair distribution function studies on various materials is presented in this dissertation. In each case, local structure information of interest pushes the current limits of what these studies can accomplish. The goal is to provide insight into the individual material behaviors as well as to investigate ways to expand the current limits of PDF analysis. Where possible, I provide a framework for how PDF analysis might be applied to a wider set of material phenomena. Throughout the dissertation, I discuss 0 the capabilities of the PDF method to provide information pertaining to a material's structure and properties, ii) current limitations in the conventional approach to PDF analysis, iii) possible solutions to overcome certain limitations in PDF analysis, and iv) suggestions for future work to expand and improve the capabilities PDF analysis.

14 CFR § 1271.205 - Professional and technical services.

Code of Federal Regulations, 2014 CFR

2014-01-01

...” shall be limited to advice and analysis directly applying any professional or technical discipline. For... providing an engineering analysis prior to the preparation or submission of a bid or proposal are not...

The Design and Analysis of Transposon-Insertion Sequencing Experiments

PubMed Central

Chao, Michael C.; Abel, Sören; Davis, Brigid M.; Waldor, Matthew K.

2016-01-01

Preface Transposon-insertion sequencing (TIS) is a powerful approach that can be widely applied to genome-wide definition of loci that are required for growth in diverse conditions. However, experimental design choices and stochastic biological processes can heavily influence the results of TIS experiments and affect downstream statistical analysis. Here, we discuss TIS experimental parameters and how these factors relate to the benefits and limitations of the various statistical frameworks that can be applied to computational analysis of TIS data. PMID:26775926

Applying STAMP in Accident Analysis

NASA Technical Reports Server (NTRS)

Leveson, Nancy; Daouk, Mirna; Dulac, Nicolas; Marais, Karen

2003-01-01

Accident models play a critical role in accident investigation and analysis. Most traditional models are based on an underlying chain of events. These models, however, have serious limitations when used for complex, socio-technical systems. Previously, Leveson proposed a new accident model (STAMP) based on system theory. In STAMP, the basic concept is not an event but a constraint. This paper shows how STAMP can be applied to accident analysis using three different views or models of the accident process and proposes a notation for describing this process.

A method for the analysis of nonlinearities in aircraft dynamic response to atmospheric turbulence

NASA Technical Reports Server (NTRS)

Sidwell, K.

1976-01-01

An analytical method is developed which combines the equivalent linearization technique for the analysis of the response of nonlinear dynamic systems with the amplitude modulated random process (Press model) for atmospheric turbulence. The method is initially applied to a bilinear spring system. The analysis of the response shows good agreement with exact results obtained by the Fokker-Planck equation. The method is then applied to an example of control-surface displacement limiting in an aircraft with a pitch-hold autopilot.

Applied statistical training to strengthen analysis and health research capacity in Rwanda.

PubMed

Thomson, Dana R; Semakula, Muhammed; Hirschhorn, Lisa R; Murray, Megan; Ndahindwa, Vedaste; Manzi, Anatole; Mukabutera, Assumpta; Karema, Corine; Condo, Jeanine; Hedt-Gauthier, Bethany

2016-09-29

To guide efficient investment of limited health resources in sub-Saharan Africa, local researchers need to be involved in, and guide, health system and policy research. While extensive survey and census data are available to health researchers and program officers in resource-limited countries, local involvement and leadership in research is limited due to inadequate experience, lack of dedicated research time and weak interagency connections, among other challenges. Many research-strengthening initiatives host prolonged fellowships out-of-country, yet their approaches have not been evaluated for effectiveness in involvement and development of local leadership in research. We developed, implemented and evaluated a multi-month, deliverable-driven, survey analysis training based in Rwanda to strengthen skills of five local research leaders, 15 statisticians, and a PhD candidate. Research leaders applied with a specific research question relevant to country challenges and committed to leading an analysis to publication. Statisticians with prerequisite statistical training and experience with a statistical software applied to participate in class-based trainings and complete an assigned analysis. Both statisticians and research leaders were provided ongoing in-country mentoring for analysis and manuscript writing. Participants reported a high level of skill, knowledge and collaborator development from class-based trainings and out-of-class mentorship that were sustained 1 year later. Five of six manuscripts were authored by multi-institution teams and submitted to international peer-reviewed scientific journals, and three-quarters of the participants mentored others in survey data analysis or conducted an additional survey analysis in the year following the training. Our model was effective in utilizing existing survey data and strengthening skills among full-time working professionals without disrupting ongoing work commitments and using few resources. Critical to our success were a transparent, robust application process and time limited training supplemented by ongoing, in-country mentoring toward manuscript deliverables that were led by Rwanda's health research leaders.

Good modeling practice guidelines for applying multimedia models in chemical assessments.

PubMed

Buser, Andreas M; MacLeod, Matthew; Scheringer, Martin; Mackay, Don; Bonnell, Mark; Russell, Mark H; DePinto, Joseph V; Hungerbühler, Konrad

2012-10-01

Multimedia mass balance models of chemical fate in the environment have been used for over 3 decades in a regulatory context to assist decision making. As these models become more comprehensive, reliable, and accepted, there is a need to recognize and adopt principles of Good Modeling Practice (GMP) to ensure that multimedia models are applied with transparency and adherence to accepted scientific principles. We propose and discuss 6 principles of GMP for applying existing multimedia models in a decision-making context, namely 1) specification of the goals of the model assessment, 2) specification of the model used, 3) specification of the input data, 4) specification of the output data, 5) conduct of a sensitivity and possibly also uncertainty analysis, and finally 6) specification of the limitations and limits of applicability of the analysis. These principles are justified and discussed with a view to enhancing the transparency and quality of model-based assessments. Copyright © 2012 SETAC.

Timing analysis by model checking

NASA Technical Reports Server (NTRS)

Naydich, Dimitri; Guaspari, David

2000-01-01

The safety of modern avionics relies on high integrity software that can be verified to meet hard real-time requirements. The limits of verification technology therefore determine acceptable engineering practice. To simplify verification problems, safety-critical systems are commonly implemented under the severe constraints of a cyclic executive, which make design an expensive trial-and-error process highly intolerant of change. Important advances in analysis techniques, such as rate monotonic analysis (RMA), have provided a theoretical and practical basis for easing these onerous restrictions. But RMA and its kindred have two limitations: they apply only to verifying the requirement of schedulability (that tasks meet their deadlines) and they cannot be applied to many common programming paradigms. We address both these limitations by applying model checking, a technique with successful industrial applications in hardware design. Model checking algorithms analyze finite state machines, either by explicit state enumeration or by symbolic manipulation. Since quantitative timing properties involve a potentially unbounded state variable (a clock), our first problem is to construct a finite approximation that is conservative for the properties being analyzed-if the approximation satisfies the properties of interest, so does the infinite model. To reduce the potential for state space explosion we must further optimize this finite model. Experiments with some simple optimizations have yielded a hundred-fold efficiency improvement over published techniques.

Analysis and Load Rating of Pre-flex Composite Beams

DTIC Science & Technology

2011-09-01

limit is temporary and applies only at the moment the load is removed during the fabrication. Once in service, the allowable compressive stress is...the analysis procedures, the load rating methodology applied in this report is based on the general Equation 19. 1 2 C - (A )(D) RF= (A )L(1+I...construction in order to generate composite beam action and, in turn, increase their flexural capacity and stiffness. With regard to live loads ,

Limitations and potential of spectral subtractions in fourier-transform infrared (FTIR) spectroscopy of soil samples

USDA-ARS?s Scientific Manuscript database

Soil science research is increasingly applying Fourier transform infrared (FTIR) spectroscopy for analysis of soil organic matter (SOM). However, the compositional complexity of soils and the dominance of the mineral component can limit spectroscopic resolution of SOM and other minor components. The...

Application of Raytracing Through the High Resolution Numerical Weather Model HIRLAM for the Analysis of European VLBI

NASA Technical Reports Server (NTRS)

Garcia-Espada, Susana; Haas, Rudiger; Colomer, Francisco

2010-01-01

An important limitation for the precision in the results obtained by space geodetic techniques like VLBI and GPS are tropospheric delays caused by the neutral atmosphere, see e.g. [1]. In recent years numerical weather models (NWM) have been applied to improve mapping functions which are used for tropospheric delay modeling in VLBI and GPS data analyses. In this manuscript we use raytracing to calculate slant delays and apply these to the analysis of Europe VLBI data. The raytracing is performed through the limited area numerical weather prediction (NWP) model HIRLAM. The advantages of this model are high spatial (0.2 deg. x 0.2 deg.) and high temporal resolution (in prediction mode three hours).

A method for limiting data acquisition in a high-resolution gamma-ray spectrometer during On-Site Inspection activities under the Comprehensive Nuclear-Test-Ban Treaty

NASA Astrophysics Data System (ADS)

Aviv, O.; Lipshtat, A.

2018-05-01

On-Site Inspection (OSI) activities under the Comprehensive Nuclear-Test-Ban Treaty (CTBT) allow limitations to measurement equipment. Thus, certain detectors require modifications to be operated in a restricted mode. The accuracy and reliability of results obtained by a restricted device may be impaired. We present here a method for limiting data acquisition during OSI. Limitations are applied to a high-resolution high-purity germanium detector system, where the vast majority of the acquired data that is not relevant to the inspection is filtered out. The limited spectrum is displayed to the user and allows analysis using standard gamma spectrometry procedures. The proposed method can be incorporated into commercial gamma-ray spectrometers, including both stationary and mobile-based systems. By applying this procedure to more than 1000 spectra, representing various scenarios, we show that partial data are sufficient for reaching reliable conclusions. A comprehensive survey of potential false-positive identifications of various radionuclides is presented as well. It is evident from the results that the analysis of a limited spectrum is practically identical to that of a standard spectrum in terms of detection and quantification of OSI-relevant radionuclides. A future limited system can be developed making use of the principles outlined by the suggested method.

Applied spectrophotometry: analysis of a biochemical mixture.

PubMed

Trumbo, Toni A; Schultz, Emeric; Borland, Michael G; Pugh, Michael Eugene

2013-01-01

Spectrophotometric analysis is essential for determining biomolecule concentration of a solution and is employed ubiquitously in biochemistry and molecular biology. The application of the Beer-Lambert-Bouguer Lawis routinely used to determine the concentration of DNA, RNA or protein. There is however a significant difference in determining the concentration of a given species (RNA, DNA, protein) in isolation (a contrived circumstance) as opposed to determining that concentration in the presence of other species (a more realistic situation). To present the student with a more realistic laboratory experience and also to fill a hole that we believe exists in student experience prior to reaching a biochemistry course, we have devised a three week laboratory experience designed so that students learn to: connect laboratory practice with theory, apply the Beer-Lambert-Bougert Law to biochemical analyses, demonstrate the utility and limitations of example quantitative colorimetric assays, demonstrate the utility and limitations of UV analyses for biomolecules, develop strategies for analysis of a solution of unknown biomolecular composition, use digital micropipettors to make accurate and precise measurements, and apply graphing software. Copyright © 2013 Wiley Periodicals, Inc.

Stochastic resonance algorithm applied to quantitative analysis for weak chromatographic signals of alkyl halides and alkyl benzenes in water samples.

PubMed

Xiang, Suyun; Wang, Wei; Xia, Jia; Xiang, Bingren; Ouyang, Pingkai

2009-09-01

The stochastic resonance algorithm is applied to the trace analysis of alkyl halides and alkyl benzenes in water samples. Compared to encountering a single signal when applying the algorithm, the optimization of system parameters for a multicomponent is more complex. In this article, the resolution of adjacent chromatographic peaks is first involved in the optimization of parameters. With the optimized parameters, the algorithm gave an ideal output with good resolution as well as enhanced signal-to-noise ratio. Applying the enhanced signals, the method extended the limit of detection and exhibited good linearity, which ensures accurate determination of the multicomponent.

Using Trial-Based Functional Analysis to Design Effective Interventions for Students Diagnosed with Autism Spectrum Disorder

ERIC Educational Resources Information Center

Larkin, Wallace; Hawkins, Renee O.; Collins, Tai

2016-01-01

Functional behavior assessments and function-based interventions are effective methods for addressing the challenging behaviors of children; however, traditional functional analysis has limitations that impact usability in applied settings. Trial-based functional analysis addresses concerns relating to the length of time, level of expertise…

Limit Cycle Analysis Applied to the Oscillations of Decelerating Blunt-Body Entry Vehicles

NASA Technical Reports Server (NTRS)

Schoenenberger, Mark; Queen, Eric M.

2008-01-01

Many blunt-body entry vehicles have nonlinear dynamic stability characteristics that produce self-limiting oscillations in flight. Several different test techniques can be used to extract dynamic aerodynamic coefficients to predict this oscillatory behavior for planetary entry mission design and analysis. Most of these test techniques impose boundary conditions that alter the oscillatory behavior from that seen in flight. Three sets of test conditions, representing three commonly used test techniques, are presented to highlight these effects. Analytical solutions to the constant-coefficient planar equations-of-motion for each case are developed to show how the same blunt body behaves differently depending on the imposed test conditions. The energy equation is applied to further illustrate the governing dynamics. Then, the mean value theorem is applied to the energy rate equation to find the effective damping for an example blunt body with nonlinear, self-limiting dynamic characteristics. This approach is used to predict constant-energy oscillatory behavior and the equilibrium oscillation amplitudes for the various test conditions. These predictions are verified with planar simulations. The analysis presented provides an overview of dynamic stability test techniques and illustrates the effects of dynamic stability, static aerodynamics and test conditions on observed dynamic motions. It is proposed that these effects may be leveraged to develop new test techniques and refine test matrices in future tests to better define the nonlinear functional forms of blunt body dynamic stability curves.

A numerical analysis to evaluate Betz's Law for vertical axis wind turbines

NASA Astrophysics Data System (ADS)

Thönnißen, F.; Marnett, M.; Roidl, B.; Schröder, W.

2016-09-01

The upper limit for the energy conversion rate of horizontal axis wind turbines (HAWT) is known as the Betz limit. Often this limit is also applied to vertical axis wind turbines (VAWT). However, a literature review reveals that early analytical and recent numerical approaches predicted values for the maximum power output of VAWTs close to or even higher than the Betz limit. Thus, it can be questioned whether the application of Betz's Law to VAWTs is justified. To answer this question, the current approach combines a free vortex model with a 2D inviscid panel code to represent the flow field of a generic VAWT. To ensure the validity of the model, an active blade pitch control system is used to avoid flow separation. An optimal pitch curve avoiding flow separation is determined for one specific turbine configuration by applying an evolutionary algorithm. The analysis yields a net power output that is slightly (≈6%) above the Betz limit. Besides the numerical result of an increased energy conversion rate, especially the identification of two physical power increasing mechanisms shows, that the application of Betz's Law to VAWTs is not justified.

28 CFR 69.300 - Professional and technical services.

Code of Federal Regulations, 2010 CFR

2010-07-01

... limited to advice and analysis directly applying any professional or technical discipline. For example... their professional or technical expertise and unless the advice or analysis is rendered directly and... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Professional and technical services. 69...

A Limitation of the Applicability of Interval Shift Analysis to Program Evaluation

ERIC Educational Resources Information Center

Hardy, Roy

1975-01-01

Interval Shift Analysis (ISA) is an adaptation of the linear programming model used to determine maximum benefits or minimal losses in quantifiable economics problems. ISA is applied to pre and posttest score distributions for 43 classes of second graders. (RC)

3-Monochloro-1,2-propandiol (3-MCPD) in soy sauce from the Bulgarian market.

PubMed

Christova-Bagdassarian, Valentina; Tishkova, Julieta A; Vrabcheva, Terry M

2013-01-01

The 3-monochloro-1,2-propandiol (3-MCPD) levels in soy sauces which contained hydrolysed vegetable protein were evaluated for the Bulgarian market. For analysis of 3-MCPD, a gas chromatography-mass spectrometry (GC-MS) method was applied with a linear range of 0.03-2.00 μg mL⁻¹ and a limit of detection (LOD) of 2.3 μg kg⁻¹ and a limit of quantification (LOQ) of 3.4 μg kg⁻¹. At these levels, the standard deviation was 5.1%, with recoveries between 81% and 102%. The method was applied to the analysis of 21 samples of soy sauce from the Bulgarian market. Results ranged from 3.7 to 185.6 μg kg⁻¹. Soy sauces produced from hydrolysed soy protein contained higher levels of 3-MCPD than naturally fermented sauces. In 38.4% of samples of Bulgarian origin, the 3-MCPD content was above the EU limit of 20 μg kg⁻¹. In all analysed samples, 33.3% had a 3-MCPD content above the EU limit.

Different spectrophotometric methods applied for the analysis of binary mixture of flucloxacillin and amoxicillin: A comparative study.

PubMed

Attia, Khalid A M; Nassar, Mohammed W I; El-Zeiny, Mohamed B; Serag, Ahmed

2016-05-15

Three different spectrophotometric methods were applied for the quantitative analysis of flucloxacillin and amoxicillin in their binary mixture, namely, ratio subtraction, absorbance subtraction and amplitude modulation. A comparative study was done listing the advantages and the disadvantages of each method. All the methods were validated according to the ICH guidelines and the obtained accuracy, precision and repeatability were found to be within the acceptable limits. The selectivity of the proposed methods was tested using laboratory prepared mixtures and assessed by applying the standard addition technique. So, they can be used for the routine analysis of flucloxacillin and amoxicillin in their binary mixtures. Copyright © 2016 Elsevier B.V. All rights reserved.

Analysis of multi-layered films. [determining dye densities by applying a regression analysis to the spectral response of the composite transparency

NASA Technical Reports Server (NTRS)

Scarpace, F. L.; Voss, A. W.

1973-01-01

Dye densities of multi-layered films are determined by applying a regression analysis to the spectral response of the composite transparency. The amount of dye in each layer is determined by fitting the sum of the individual dye layer densities to the measured dye densities. From this, dye content constants are calculated. Methods of calculating equivalent exposures are discussed. Equivalent exposures are a constant amount of energy over a limited band-width that will give the same dye content constants as the real incident energy. Methods of using these equivalent exposures for analysis of photographic data are presented.

The Case for Licensure of Applied Behavior Analysts

PubMed Central

Dorsey, Michael F; Weinberg, Michael; Zane, Thomas; Guidi, Megan M

2009-01-01

The evolution of the field of applied behavior analysis to a practice-oriented profession has created the need to ensure that the consumers of these services are adequately protected. We review the limitations of the current board certification process and present a rationale for the establishment of licensing standards for applied behavior analysts on a state-by-state basis. Recommendations for securing the passage of a licensure bill also are discussed. PMID:22477697

Language Problems in Applied Linguistics: Limiting the Scope

ERIC Educational Resources Information Center

Kadarisman, A. Effendi

2014-01-01

This article critically discusses the paradigmatic shift in applied linguistics, resulting in a claim that countless real-world language problems fall within its scope, but in reality they weaken the discipline and make it lack a focus. Then it takes a closer look at the nature of these language problems, and picks out, for analysis, real examples…

Applying survival analysis to a large-scale forest inventory for assessment of tree mortality in Minnesota

Treesearch

C.W. Woodall; P.L. Grambsch; W. Thomas

2005-01-01

Tree mortality has traditionally been assessed in forest inventories through summaries of mortality by location, species, and causal agents. Although these methods have historically constituted the majority of tree mortality summarizations, they have had limited use in assessing mortality trends and dynamics. This study proposed a novel method of applying survival...

15 CFR 28.300 - Professional and technical services.

Code of Federal Regulations, 2010 CFR

2010-01-01

... limited to advice and analysis directly applying any professional or technical discipline. For example... their professional or technical expertise and unless the advice or analysis is rendered directly and... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Professional and technical services...

43 CFR 18.300 - Professional and technical services.

Code of Federal Regulations, 2010 CFR

2010-10-01

... limited to advice and analysis directly applying any professional or technical discipline. For example... their professional or technical expertise and unless the advice or analysis is rendered directly and... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Professional and technical services. 18...

Image contrast of diffraction-limited telescopes for circular incoherent sources of uniform radiance

NASA Technical Reports Server (NTRS)

Shackleford, W. L.

1980-01-01

A simple approximate formula is derived for the background intensity beyond the edge of the image of uniform incoherent circular light source relative to the irradiance near the center of the image. The analysis applies to diffraction-limited telescopes with or without central beam obscuration due to a secondary mirror. Scattering off optical surfaces is neglected. The analysis is expected to be most applicable to spaceborne IR telescopes, for which diffraction can be the major source of off-axis response.

Program budgeting and marginal analysis: a case study in chronic airflow limitation.

PubMed

Crockett, A; Cranston, J; Moss, J; Scown, P; Mooney, G; Alpers, J

1999-01-01

Program budgeting and marginal analysis is a method of priority-setting in health care. This article describes how this method was applied to the management of a disease-specific group, chronic airflow limitation. A sub-program flow chart clarified the major cost drivers. After assessment of the technical efficiency of the sub-programs and careful and detailed analysis, incremental and decremental wish lists of activities were established. Program budgeting and marginal analysis provides a framework for rational resource allocation. The nurturing of a vigorous program management group, with members representing all participants in the process (including patients/consumers), is the key to a successful outcome.

Emotional Issues and Peer Relations in Gifted Elementary Students: Regression Analysis of National Data

ERIC Educational Resources Information Center

Wiley, Kristofor R.

2013-01-01

Many of the social and emotional needs that have historically been associated with gifted students have been questioned on the basis of recent empirical evidence. Research on the topic, however, is often limited by sample size, selection bias, or definition. This study addressed these limitations by applying linear regression methodology to data…

Defining and Applying Limits for Test and Flight Through the Project Lifecycle GSFC Standard. [Scope: Non-Cryogenic Systems Tested in Vacuum

NASA Technical Reports Server (NTRS)

Mosier, Carol

2015-01-01

The presentation will be given at the Annual Thermal Fluids Analysis Workshop (TFAWS 2015, NCTS 21070-15) hosted by the Goddard SpaceFlight Center (GSFC) Thermal Engineering Branch (Code 545). The powerpoint presentation details the process of defining limits throughout the lifecycle of a flight project.

Surface temperatures and glassy state investigations in tribology

NASA Technical Reports Server (NTRS)

Bair, S.; Winer, W. O.

1979-01-01

The limiting shear stress shear rheological model was applied to property measurements pursuant to the use of the constitutive equation and the application of the constitutive equation to elastrohydrodynamic (EHD) traction. Experimental techniques were developed to subject materials to isothermal compression which is similar to the history the materials were subjected to in EHD contacts. In addition, an apparatus was developed for measuring the shear stress-strain behavior of solid lubricating materials. Four commercially available materials were examined under pressure. They exhibit elastic and limiting shear stress behavior similar to that of liquid lubricants. The application of the limiting shear stress model to traction predictions was extended employing the primary materials properties measured in the laboratory. The shear rheological model was also applied to a Grubin-like EHD inlet analysis for predicting film thicknesses when employing the limiting shear stress model material behavior.

Modeling Acceleration of a System of Two Objects Using the Concept of Limits

NASA Astrophysics Data System (ADS)

Sokolowski, Andrzej

2018-01-01

Traditional school laboratory exercises on a system of moving objects connected by strings involve deriving expressions for the system acceleration, a = (∑F )/m, and sketching a graph of acceleration vs. force. While being in the form of rational functions, these expressions present great opportunities for broadening the scope of the analysis by using a more sophisticated math apparatus—the concept of limits. Using the idea of limits allows for extending both predictions and explanations of this type of motion that are—according to Redish—essential goals of teaching physics. This type of analysis, known in physics as limiting case analysis, allows for generalizing inferences by evaluating or estimating values of algebraic functions based on its extreme inputs. In practice, such transition provides opportunities for deriving valid conclusions for cases when direct laboratory measurements are not possible. While using limits is common for scientists, the idea of applying limits in school practice is not visible, and testing students' ability in this area is also rare.

Survival analysis, or what to do with upper limits in astronomical surveys

NASA Technical Reports Server (NTRS)

Isobe, Takashi; Feigelson, Eric D.

1986-01-01

A field of applied statistics called survival analysis has been developed over several decades to deal with censored data, which occur in astronomical surveys when objects are too faint to be detected. How these methods can assist in the statistical interpretation of astronomical data are reviewed.

Characterization of applied fields for ion mobility in traveling wave based structures for lossless ion manipulations (SLIM)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hamid, Ahmed M.; Prabhakaran Nair Syamala Amma, Aneesh; Garimella, Venkata BS

2018-03-21

Ion mobility (IM) is rapidly gaining attention for the analysis of biomolecules due to the ability to distinguish the shapes of ions. However, conventional constant electric field drift tube IM has limited resolving power, constrained by practical limitations on the path length and maximum applied voltage. The implementation of traveling waves (TW) in IM removes the latter limitation, allowing higher resolution to be achieved using extended path lengths. These can be readily obtainable in structures for lossless ion manipulations (SLIM), which are fabricated from electric fields that are generated by appropriate potentials applied to arrays of electrodes patterned on twomore » parallel surfaces. In this work we have investigated the relationship between the various SLIM variables, such as electrode dimensions, inter-surface gap, and the TW applied voltages, that directly impact the fields experienced by ions. Ion simulation and theoretical calculations have been utilized to understand the dependence of SLIM geometry and effective electric field. The variables explored impact both ion confinement and the observed IM resolution in Structures for Lossless Ion Manipulations (SLIM) modules.« less

Characterization of applied fields for ion mobility separations in traveling wave based structures for lossless ion manipulations (SLIM)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hamid, Ahmed M.; Prabhakaran, Aneesh; Garimella, Sandilya V. B.

Ion mobility (IM) is rapidly gaining attention for the analysis of biomolecules due to the ability to distinguish the shapes of ions. However, conventional constant electric field drift tube IM has limited resolving power, constrained by practical limitations on the path length and maximum applied voltage. The implementation of traveling waves (TW) in IM removes the latter limitation, allowing higher resolution to be achieved using extended path lengths. These can be readily obtainable in structures for lossless ion manipulations (SLIM), which are fabricated from electric fields that are generated by appropriate potentials applied to arrays of electrodes patterned on twomore » parallel surfaces. In this work we have investigated the relationship between the various SLIM variables, such as electrode dimensions, inter-surface gap, and the TW applied voltages, that directly impact the fields experienced by ions. Ion simulation and theoretical calculations have been utilized to understand the dependence of SLIM geometry and effective electric field. The variables explored impact both ion confinement and the observed IM resolution in Structures for Lossless Ion Manipulations (SLIM) modules.« less

Word Problems and Make-Believe: Using Frame Analysis and Ethnomethodology to Explore Aspects of the Culture of Schooling

ERIC Educational Resources Information Center

Benincasa, Luciana

2017-01-01

The paper applies Goffman's frame analysis and ethnomethodology to student performance on mathematical word problems. In educational research, frame analysis has usually been limited to primary frames. Instead, in this paper I focus on the kind of secondary frame that Goffman calls 'utilitarian make-believe'. The data consist of a fragment of…

Using the Origin and Pawn, Positive Affect, CASPM, and Cognitive Anxiety Content Analysis Scales in Counseling Research

ERIC Educational Resources Information Center

Viney, Linda L.; Caputi, Peter

2005-01-01

Content analysis scales apply rigorous measurement to verbal communications and make possible the quantification of text in counseling research. The limitations of the Origin and Pawn Scales (M. T. Westbrook & L. L. Viney, 1980), the Positive Affect Scale (M. T. Westbrook, 1976), the Content Analysis Scales of Psychosocial Maturity (CASPM; L.…

Assessment of drug-induced arrhythmic risk using limit cycle and autocorrelation analysis of human iPSC-cardiomyocyte contractility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kirby, R. Jason

2016-08-15

Cardiac safety assays incorporating label-free detection of human stem-cell derived cardiomyocyte contractility provide human relevance and medium throughput screening to assess compound-induced cardiotoxicity. In an effort to provide quantitative analysis of the large kinetic datasets resulting from these real-time studies, we applied bioinformatic approaches based on nonlinear dynamical system analysis, including limit cycle analysis and autocorrelation function, to systematically assess beat irregularity. The algorithms were integrated into a software program to seamlessly generate results for 96-well impedance-based data. Our approach was validated by analyzing dose- and time-dependent changes in beat patterns induced by known proarrhythmic compounds and screening a cardiotoxicitymore » library to rank order compounds based on their proarrhythmic potential. We demonstrate a strong correlation for dose-dependent beat irregularity monitored by electrical impedance and quantified by autocorrelation analysis to traditional manual patch clamp potency values for hERG blockers. In addition, our platform identifies non-hERG blockers known to cause clinical arrhythmia. Our method provides a novel suite of medium-throughput quantitative tools for assessing compound effects on cardiac contractility and predicting compounds with potential proarrhythmia and may be applied to in vitro paradigms for pre-clinical cardiac safety evaluation. - Highlights: • Impedance-based monitoring of human iPSC-derived cardiomyocyte contractility • Limit cycle analysis of impedance data identifies aberrant oscillation patterns. • Nonlinear autocorrelation function quantifies beat irregularity. • Identification of hERG and non-hERG inhibitors with known risk of arrhythmia • Automated software processes limit cycle and autocorrelation analyses of 96w data.« less

Multiple fingerprinting analyses in quality control of Cassiae Semen polysaccharides.

PubMed

Cheng, Jing; He, Siyu; Wan, Qiang; Jing, Pu

2018-03-01

Quality control issue overshadows potential health benefits of Cassiae Semen due to the analytic limitations. In this study, multiple-fingerprint analysis integrated with several chemometrics was performed to assess the polysaccharide quality of Cassiae Semen harvested from different locations. FT-IR, HPLC, and GC fingerprints of polysaccharide extracts from the authentic source were established as standard profiles, applying to assess the quality of foreign sources. Analyses of FT-IR fingerprints of polysaccharide extracts using either Pearson correlation analysis or principal component analysis (PCA), or HPLC fingerprints of partially hydrolyzed polysaccharides with PCA, distinguished the foreign sources from the authentic source. However, HPLC or GC fingerprints of completely hydrolyzed polysaccharides couldn't identify all foreign sources and the methodology using GC is quite limited in determining the monosaccharide composition. This indicates that FT-IR/HPLC fingerprints of non/partially-hydrolyzed polysaccharides, respectively, accompanied by multiple chemometrics methods, might be potentially applied in detecting and differentiating sources of Cassiae Semen. Copyright © 2018 Elsevier B.V. All rights reserved.

A modification of Murray's law for shear-thinning rheology.

PubMed

McGah, Patrick M; Capobianchi, Massimo

2015-05-01

This study reformulates Murray's well-known principle of minimum work as applied to the cardiovascular system to include the effects of the shear-thinning rheology of blood. The viscous behavior is described using the extended modified power law (EMPL), which is a time-independent, but shear-thinning rheological constitutive equation. The resulting minimization problem is solved numerically for typical parameter ranges. The non-Newtonian analysis still predicts the classical cubic diameter dependence of the volume flow rate and the cubic branching law. The current analysis also predicts a constant wall shear stress throughout the vascular tree, albeit with a numerical value about 15-25% higher than the Newtonian analysis. Thus, experimentally observed deviations from the cubic branching law or the predicted constant wall shear stress in the vasculature cannot likely be attributed to blood's shear-thinning behavior. Further differences between the predictions of the non-Newtonian and the Newtonian analyses are highlighted, and the limitations of the Newtonian analysis are discussed. Finally, the range and limits of applicability of the current results as applied to the human arterial tree are also discussed.

Continuous Wavelet Transform, a powerful alternative to Derivative Spectrophotometry in analysis of binary and ternary mixtures: A comparative study.

PubMed

Elzanfaly, Eman S; Hassan, Said A; Salem, Maissa Y; El-Zeany, Badr A

2015-12-05

A comparative study was established between two signal processing techniques showing the theoretical algorithm for each method and making a comparison between them to indicate the advantages and limitations. The methods under study are Numerical Differentiation (ND) and Continuous Wavelet Transform (CWT). These methods were studied as spectrophotometric resolution tools for simultaneous analysis of binary and ternary mixtures. To present the comparison, the two methods were applied for the resolution of Bisoprolol (BIS) and Hydrochlorothiazide (HCT) in their binary mixture and for the analysis of Amlodipine (AML), Aliskiren (ALI) and Hydrochlorothiazide (HCT) as an example for ternary mixtures. By comparing the results in laboratory prepared mixtures, it was proven that CWT technique is more efficient and advantageous in analysis of mixtures with severe overlapped spectra than ND. The CWT was applied for quantitative determination of the drugs in their pharmaceutical formulations and validated according to the ICH guidelines where accuracy, precision, repeatability and robustness were found to be within the acceptable limit. Copyright © 2015 Elsevier B.V. All rights reserved.

Analysis of Selected Enhancements for Soil Vapor Extraction

DTIC Science & Technology

1997-09-01

Inches per second ACRONYMS AND ABBREVIATIONS (Continued) xiii ISB In situ bioremediation JFK John F. Kennedy Airport K Hydraulic conductivity KAI KAI...wells by an applied vacuum. RFH is effective for treating VOCs in low-permeability soil in the vadose zone. Electrical Resistance Heating : This... applied vacuum. However, application of steam injection/stripping systems is limited to medium- to high-permeability soils. ER heating is more

Laser-induced fluorescence microscopic system using an optical parametric oscillator for tunable detection in microchip analysis.

PubMed

Kumemura, Momoko; Odake, Tamao; Korenaga, Takashi

2005-06-01

A laser-induced fluorescence microscopic system based on optical parametric oscillation has been constructed as a tunable detector for microchip analysis. The detection limit of sulforhodamine B (Ex. 520 nm, Em. 570 nm) was 0.2 mumol, which was approximately eight orders of magnitude better than with a conventional fluorophotometer. The system was applied to the determination of fluorescence-labeled DNA (Ex. 494 nm, Em. 519 nm) in a microchannel and the detection limit reached a single molecule. These results showed the feasibility of this system as a highly sensitive and tunable fluorescence detector for microchip analysis.

Single photon detection and signal analysis for high sensitivity dosimetry based on optically stimulated luminescence with beryllium oxide

NASA Astrophysics Data System (ADS)

Radtke, J.; Sponner, J.; Jakobi, C.; Schneider, J.; Sommer, M.; Teichmann, T.; Ullrich, W.; Henniger, J.; Kormoll, T.

2018-01-01

Single photon detection applied to optically stimulated luminescence (OSL) dosimetry is a promising approach due to the low level of luminescence light and the known statistical behavior of single photon events. Time resolved detection allows to apply a variety of different and independent data analysis methods. Furthermore, using amplitude modulated stimulation impresses time- and frequency information into the OSL light and therefore allows for additional means of analysis. Considering the impressed frequency information, data analysis by using Fourier transform algorithms or other digital filters can be used for separating the OSL signal from unwanted light or events generated by other phenomena. This potentially lowers the detection limits of low dose measurements and might improve the reproducibility and stability of obtained data. In this work, an OSL system based on a single photon detector, a fast and accurate stimulation unit and an FPGA is presented. Different analysis algorithms which are applied to the single photon data are discussed.

Fast Detection of Copper Content in Rice by Laser-Induced Breakdown Spectroscopy with Uni- and Multivariate Analysis.

PubMed

Liu, Fei; Ye, Lanhan; Peng, Jiyu; Song, Kunlin; Shen, Tingting; Zhang, Chu; He, Yong

2018-02-27

Fast detection of heavy metals is very important for ensuring the quality and safety of crops. Laser-induced breakdown spectroscopy (LIBS), coupled with uni- and multivariate analysis, was applied for quantitative analysis of copper in three kinds of rice (Jiangsu rice, regular rice, and Simiao rice). For univariate analysis, three pre-processing methods were applied to reduce fluctuations, including background normalization, the internal standard method, and the standard normal variate (SNV). Linear regression models showed a strong correlation between spectral intensity and Cu content, with an R 2 more than 0.97. The limit of detection (LOD) was around 5 ppm, lower than the tolerance limit of copper in foods. For multivariate analysis, partial least squares regression (PLSR) showed its advantage in extracting effective information for prediction, and its sensitivity reached 1.95 ppm, while support vector machine regression (SVMR) performed better in both calibration and prediction sets, where R c 2 and R p 2 reached 0.9979 and 0.9879, respectively. This study showed that LIBS could be considered as a constructive tool for the quantification of copper contamination in rice.

Fast Detection of Copper Content in Rice by Laser-Induced Breakdown Spectroscopy with Uni- and Multivariate Analysis

PubMed Central

Ye, Lanhan; Song, Kunlin; Shen, Tingting

2018-01-01

Fast detection of heavy metals is very important for ensuring the quality and safety of crops. Laser-induced breakdown spectroscopy (LIBS), coupled with uni- and multivariate analysis, was applied for quantitative analysis of copper in three kinds of rice (Jiangsu rice, regular rice, and Simiao rice). For univariate analysis, three pre-processing methods were applied to reduce fluctuations, including background normalization, the internal standard method, and the standard normal variate (SNV). Linear regression models showed a strong correlation between spectral intensity and Cu content, with an R2 more than 0.97. The limit of detection (LOD) was around 5 ppm, lower than the tolerance limit of copper in foods. For multivariate analysis, partial least squares regression (PLSR) showed its advantage in extracting effective information for prediction, and its sensitivity reached 1.95 ppm, while support vector machine regression (SVMR) performed better in both calibration and prediction sets, where Rc2 and Rp2 reached 0.9979 and 0.9879, respectively. This study showed that LIBS could be considered as a constructive tool for the quantification of copper contamination in rice. PMID:29495445

Analysis of concrete beams using applied element method

NASA Astrophysics Data System (ADS)

Lincy Christy, D.; Madhavan Pillai, T. M.; Nagarajan, Praveen

2018-03-01

The Applied Element Method (AEM) is a displacement based method of structural analysis. Some of its features are similar to that of Finite Element Method (FEM). In AEM, the structure is analysed by dividing it into several elements similar to FEM. But, in AEM, elements are connected by springs instead of nodes as in the case of FEM. In this paper, background to AEM is discussed and necessary equations are derived. For illustrating the application of AEM, it has been used to analyse plain concrete beam of fixed support condition. The analysis is limited to the analysis of 2-dimensional structures. It was found that the number of springs has no much influence on the results. AEM could predict deflection and reactions with reasonable degree of accuracy.

Development of a probabilistic analysis methodology for structural reliability estimation

NASA Technical Reports Server (NTRS)

Torng, T. Y.; Wu, Y.-T.

1991-01-01

The novel probabilistic analysis method for assessment of structural reliability presented, which combines fast-convolution with an efficient structural reliability analysis, can after identifying the most important point of a limit state proceed to establish a quadratic-performance function. It then transforms the quadratic function into a linear one, and applies fast convolution. The method is applicable to problems requiring computer-intensive structural analysis. Five illustrative examples of the method's application are given.

Validation of a near infrared microscopy method for the detection of animal products in feedingstuffs: results of a collaborative study.

PubMed

Boix, A; Fernández Pierna, J A; von Holst, C; Baeten, V

2012-01-01

The performance characteristics of a near infrared microscopy (NIRM) method, when applied to the detection of animal products in feedingstuffs, were determined via a collaborative study. The method delivers qualitative results in terms of the presence or absence of animal particles in feed and differentiates animal from vegetable feed ingredients on the basis of the evaluation of near infrared spectra obtained from individual particles present in the sample. The specificity ranged from 86% to 100%. The limit of detection obtained on the analysis of the sediment fraction, prepared as for the European official method, was 0.1% processed animal proteins (PAPs) in feed, since all laboratories correctly identified the positive samples. This limit has to be increased up to 2% for the analysis of samples which are not sedimented. The required sensitivity for the official control is therefore achieved in the analysis of the sediment fraction of the samples where the method can be applied for the detection of the presence of animal meal. Criteria for the classification of samples, when fewer than five spectra are found, as being of animal origin needs to be set up in order to harmonise the approach taken by the laboratories when applying NIRM for the detection of the presence of animal meal in feed.

Beyond the Margins: Evaluating the Support for Multicultural Education within Teachers' Editions of U.S. History Textbooks

ERIC Educational Resources Information Center

Stanton, Christine Rogers

2015-01-01

Although previous research has described analysis of history textbooks in terms of multicultural education, limited attention has been given to teacher only resources, such as the "wraparound features" of teachers' editions. The study highlighted in this article applies critical discourse analysis to explore the potential for teachers'…

Utility of KTEA-3 Error Analysis for the Diagnosis of Specific Learning Disabilities

ERIC Educational Resources Information Center

Flanagan, Dawn P.; Mascolo, Jennifer T.; Alfonso, Vincent C.

2017-01-01

Through the use of excerpts from one of our own case studies, this commentary applied concepts inherent in, but not limited to, the neuropsychological literature to the interpretation of performance on the Kaufman Tests of Educational Achievement-Third Edition (KTEA-3), particularly at the level of error analysis. The approach to KTEA-3 test…

Characterization of applied fields for ion mobility separations in traveling wave based structures for lossless ion manipulations (SLIM)

DOE PAGES

Hamid, Ahmed M.; Prabhakaran, Aneesh; Garimella, Sandilya V. B.; ...

2018-03-26

Ion mobility (IM) is rapidly gaining attention for the separation and analysis of biomolecules due to the ability to distinguish the shapes of ions. However, conventional constant electric field drift tube IM separations have limited resolving power, constrained by practical limitations on the path length and maximum applied voltage. The implementation of traveling waves (TW) in IM removes the latter limitation, allowing higher resolution to be achieved using extended path lengths. Both of these can be readily obtained in Structures for Lossless Ion Manipulations (SLIM), which are fabricated from arrays of electrodes patterned on two parallel surfaces where potentials aremore » applied to generate appropriate electric fields between the surfaces. Here we have investigated the relationship between the primary SLIM variables, such as electrode dimensions, inter-surface gap, and the applied TW voltages, that directly impact the fields experienced by ions. Ion trajectory simulations and theoretical calculations have been utilized to understand the dependence of SLIM geometry and effective electric fields on IM resolution. The variables explored impact both ion confinement and the observed IM resolution using SLIM modules.« less

Characterization of applied fields for ion mobility separations in traveling wave based structures for lossless ion manipulations (SLIM)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hamid, Ahmed M.; Prabhakaran, Aneesh; Garimella, Sandilya V. B.

Ion mobility (IM) is rapidly gaining attention for the separation and analysis of biomolecules due to the ability to distinguish the shapes of ions. However, conventional constant electric field drift tube IM separations have limited resolving power, constrained by practical limitations on the path length and maximum applied voltage. The implementation of traveling waves (TW) in IM removes the latter limitation, allowing higher resolution to be achieved using extended path lengths. Both of these can be readily obtained in Structures for Lossless Ion Manipulations (SLIM), which are fabricated from arrays of electrodes patterned on two parallel surfaces where potentials aremore » applied to generate appropriate electric fields between the surfaces. Here we have investigated the relationship between the primary SLIM variables, such as electrode dimensions, inter-surface gap, and the applied TW voltages, that directly impact the fields experienced by ions. Ion trajectory simulations and theoretical calculations have been utilized to understand the dependence of SLIM geometry and effective electric fields on IM resolution. The variables explored impact both ion confinement and the observed IM resolution using SLIM modules.« less

Kernel-Phase Interferometry for Super-Resolution Detection of Faint Companions

NASA Astrophysics Data System (ADS)

Factor, Samuel M.; Kraus, Adam L.

2017-01-01

Direct detection of close in companions (exoplanets or binary systems) is notoriously difficult. While coronagraphs and point spread function (PSF) subtraction can be used to reduce contrast and dig out signals of companions under the PSF, there are still significant limitations in separation and contrast. Non-redundant aperture masking (NRM) interferometry can be used to detect companions well inside the PSF of a diffraction limited image, though the mask discards ˜95% of the light gathered by the telescope and thus the technique is severely flux limited. Kernel-phase analysis applies interferometric techniques similar to NRM to a diffraction limited image utilizing the full aperture. Instead of non-redundant closure-phases, kernel-phases are constructed from a grid of points on the full aperture, simulating a redundant interferometer. I have developed my own faint companion detection pipeline which utilizes an Bayesian analysis of kernel-phases. I have used this pipeline to search for new companions in archival images from HST/NICMOS in order to constrain planet and binary formation models at separations inaccessible to previous techniques. Using this method, it is possible to detect a companion well within the classical λ/D Rayleigh diffraction limit using a fraction of the telescope time as NRM. This technique can easily be applied to archival data as no mask is needed and will thus make the detection of close in companions cheap and simple as no additional observations are needed. Since the James Webb Space Telescope (JWST) will be able to perform NRM observations, further development and characterization of kernel-phase analysis will allow efficient use of highly competitive JWST telescope time.

Nonparametric rank regression for analyzing water quality concentration data with multiple detection limits.

PubMed

Fu, Liya; Wang, You-Gan

2011-02-15

Environmental data usually include measurements, such as water quality data, which fall below detection limits, because of limitations of the instruments or of certain analytical methods used. The fact that some responses are not detected needs to be properly taken into account in statistical analysis of such data. However, it is well-known that it is challenging to analyze a data set with detection limits, and we often have to rely on the traditional parametric methods or simple imputation methods. Distributional assumptions can lead to biased inference and justification of distributions is often not possible when the data are correlated and there is a large proportion of data below detection limits. The extent of bias is usually unknown. To draw valid conclusions and hence provide useful advice for environmental management authorities, it is essential to develop and apply an appropriate statistical methodology. This paper proposes rank-based procedures for analyzing non-normally distributed data collected at different sites over a period of time in the presence of multiple detection limits. To take account of temporal correlations within each site, we propose an optimal linear combination of estimating functions and apply the induced smoothing method to reduce the computational burden. Finally, we apply the proposed method to the water quality data collected at Susquehanna River Basin in United States of America, which clearly demonstrates the advantages of the rank regression models.

Methods for assessing the stability of slopes during earthquakes-A retrospective

USGS Publications Warehouse

Jibson, R.W.

2011-01-01

During the twentieth century, several methods to assess the stability of slopes during earthquakes were developed. Pseudostatic analysis was the earliest method; it involved simply adding a permanent body force representing the earthquake shaking to a static limit-equilibrium analysis. Stress-deformation analysis, a later development, involved much more complex modeling of slopes using a mesh in which the internal stresses and strains within elements are computed based on the applied external loads, including gravity and seismic loads. Stress-deformation analysis provided the most realistic model of slope behavior, but it is very complex and requires a high density of high-quality soil-property data as well as an accurate model of soil behavior. In 1965, Newmark developed a method that effectively bridges the gap between these two types of analysis. His sliding-block model is easy to apply and provides a useful index of co-seismic slope performance. Subsequent modifications to sliding-block analysis have made it applicable to a wider range of landslide types. Sliding-block analysis provides perhaps the greatest utility of all the types of analysis. It is far easier to apply than stress-deformation analysis, and it yields much more useful information than does pseudostatic analysis. ?? 2010.

High resolution separations of charge variants and disulfide isomers of monoclonal antibodies and antibody drug conjugates using ultra-high voltage capillary electrophoresis with high electric field strength.

PubMed

Henley, W Hampton; He, Yan; Mellors, J Scott; Batz, Nicholas G; Ramsey, J Michael; Jorgenson, James W

2017-11-10

Ultra-high voltage capillary electrophoresis with high electric field strength has been applied to the separation of the charge variants, drug conjugates, and disulfide isomers of monoclonal antibodies. Samples composed of many closely related species are difficult to resolve and quantify using traditional analytical instrumentation. High performance instrumentation can often save considerable time and effort otherwise spent on extensive method development. Ideally, the resolution obtained for a given CE buffer system scales with the square root of the applied voltage. Currently available commercial CE instrumentation is limited to an applied voltage of approximately 30kV and a maximum electric field strength of 1kV/cm due to design limitations. The instrumentation described here is capable of safely applying potentials of at least 120kV with electric field strengths over 2000V/cm, potentially doubling the resolution of the best conventional CE buffer/capillary systems while decreasing analysis time in some applications. Separations of these complex mixtures using this new instrumentation demonstrate the potential of ultra-high voltage CE to identify the presence of previously unresolved components and to reduce analysis time for complex mixtures of antibody variants and drug conjugates. Copyright © 2017 Elsevier B.V. All rights reserved.

29 CFR 1608.11 - Limitations on the application of these guidelines.

Code of Federal Regulations, 2013 CFR

2013-07-01

... do not apply to, and the section 713(b)(1) defense is not available for the purpose of, determining... such factors as progress in correcting the conditions disclosed by the self analysis. The currency of...

29 CFR 1608.11 - Limitations on the application of these guidelines.

Code of Federal Regulations, 2011 CFR

2011-07-01

... do not apply to, and the section 713(b)(1) defense is not available for the purpose of, determining... such factors as progress in correcting the conditions disclosed by the self analysis. The currency of...

29 CFR 1608.11 - Limitations on the application of these guidelines.

Code of Federal Regulations, 2012 CFR

2012-07-01

... do not apply to, and the section 713(b)(1) defense is not available for the purpose of, determining... such factors as progress in correcting the conditions disclosed by the self analysis. The currency of...

Accounting for the dissociating properties of organic chemicals in LCIA: an uncertainty analysis applied to micropollutants in the assessment of freshwater ecotoxicity.

PubMed

Morais, Sérgio Alberto; Delerue-Matos, Cristina; Gabarrell, Xavier

2013-03-15

In life cycle impact assessment (LCIA) models, the sorption of the ionic fraction of dissociating organic chemicals is not adequately modeled because conventional non-polar partitioning models are applied. Therefore, high uncertainties are expected when modeling the mobility, as well as the bioavailability for uptake by exposed biota and degradation, of dissociating organic chemicals. Alternative regressions that account for the ionized fraction of a molecule to estimate fate parameters were applied to the USEtox model. The most sensitive model parameters in the estimation of ecotoxicological characterization factors (CFs) of micropollutants were evaluated by Monte Carlo analysis in both the default USEtox model and the alternative approach. Negligible differences of CFs values and 95% confidence limits between the two approaches were estimated for direct emissions to the freshwater compartment; however the default USEtox model overestimates CFs and the 95% confidence limits of basic compounds up to three orders and four orders of magnitude, respectively, relatively to the alternative approach for emissions to the agricultural soil compartment. For three emission scenarios, LCIA results show that the default USEtox model overestimates freshwater ecotoxicity impacts for the emission scenarios to agricultural soil by one order of magnitude, and larger confidence limits were estimated, relatively to the alternative approach. Copyright © 2013 Elsevier B.V. All rights reserved.

Standardization of pitch-range settings in voice acoustic analysis.

PubMed

Vogel, Adam P; Maruff, Paul; Snyder, Peter J; Mundt, James C

2009-05-01

Voice acoustic analysis is typically a labor-intensive, time-consuming process that requires the application of idiosyncratic parameters tailored to individual aspects of the speech signal. Such processes limit the efficiency and utility of voice analysis in clinical practice as well as in applied research and development. In the present study, we analyzed 1,120 voice files, using standard techniques (case-by-case hand analysis), taking roughly 10 work weeks of personnel time to complete. The results were compared with the analytic output of several automated analysis scripts that made use of preset pitch-range parameters. After pitch windows were selected to appropriately account for sex differences, the automated analysis scripts reduced processing time of the 1,120 speech samples to less than 2.5 h and produced results comparable to those obtained with hand analysis. However, caution should be exercised when applying the suggested preset values to pathological voice populations.

Current practices in the spatial analysis of cancer: flies in the ointment

PubMed Central

Jacquez, Geoffrey M

2004-01-01

While many lessons have been learned from the spatial analysis of cancer, there are several caveats that apply to many, if not all such analyses. As "flies in the ointment", these can substantially detract from a spatial analysis, and if not accounted for, can lead to weakened and erroneous conclusions. This paper discusses several assumptions and limitations of spatial analysis, identifies problems of scientific inference, and concludes with potential solutions and future directions. PMID:15479473

Energetic ion mass analysis using a radio-frequency quadrupole filter.

PubMed

Medley, S S

1978-06-01

In conventional applications of the radio-frequency quadrupole mass analyzer, the ion injection energy is usually limited to less than the order of 100 eV due to constraints on the dimensions and power supply of the device. However, requirements often arise, for example in fusion plasma ion diagnostics, for mass analysis of much more energetic ions. A technique easily adaptable to any conventional quadrupole analyzer which circumvents the limitation on injection energy is documented in this paper. Briefly, a retarding potential applied to the pole assembly is shown to facilitate mass analysis of multikiloelectron volt ions without altering the salient characteristics of either the quadrupole filter or the ion beam.

Integrated Multi-process Microfluidic Systems for Automating Analysis

PubMed Central

Yang, Weichun; Woolley, Adam T.

2010-01-01

Microfluidic technologies have been applied extensively in rapid sample analysis. Some current challenges for standard microfluidic systems are relatively high detection limits, and reduced resolving power and peak capacity compared to conventional approaches. The integration of multiple functions and components onto a single platform can overcome these separation and detection limitations of microfluidics. Multiplexed systems can greatly increase peak capacity in multidimensional separations and can increase sample throughput by analyzing many samples simultaneously. On-chip sample preparation, including labeling, preconcentration, cleanup and amplification, can all serve to speed up and automate processes in integrated microfluidic systems. This paper summarizes advances in integrated multi-process microfluidic systems for automated analysis, their benefits and areas for needed improvement. PMID:20514343

Elasto-limited plastic analysis of structures for probabilistic conditions

NASA Astrophysics Data System (ADS)

Movahedi Rad, M.

2018-06-01

With applying plastic analysis and design methods, significant saving in material can be obtained. However, as a result of this benefit excessive plastic deformations and large residual displacements might develop, which in turn might lead to unserviceability and collapse of the structure. In this study, for deterministic problem the residual deformation of structures is limited by considering a constraint on the complementary strain energy of the residual forces. For probabilistic problem the constraint for the complementary strain energy of the residual forces is given randomly and critical stresses updated during the iteration. Limit curves are presented for the plastic limit load factors. The results show that these constraints have significant effects on the load factors. The formulations of the deterministic and probabilistic problems lead to mathematical programming which are solved by the use of nonlinear algorithm.

A study in the founding of applied behavior analysis through its publications.

PubMed

Morris, Edward K; Altus, Deborah E; Smith, Nathaniel G

2013-01-01

This article reports a study of the founding of applied behavior analysis through its publications. Our methods included hand searches of sources (e.g., journals, reference lists), search terms (i.e., early, applied, behavioral, research, literature), inclusion criteria (e.g., the field's applied dimension), and (d) challenges to their face and content validity. Our results were 36 articles published between 1959 and 1967 that we organized into 4 groups: 12 in 3 programs of research and 24 others. Our discussion addresses (a) limitations in our method (e.g., the completeness of our search), (b) challenges to the validity of our methods and results (e.g., convergent validity), and (c) priority claims about the field's founding. We conclude that the claims are irresolvable because identification of the founding publications depends significantly on methods and because the field's founding was an evolutionary process. We close with suggestions for future research.

A Study in the Founding of Applied Behavior Analysis Through Its Publications

PubMed Central

Morris, Edward K.; Altus, Deborah E.; Smith, Nathaniel G.

2013-01-01

This article reports a study of the founding of applied behavior analysis through its publications. Our methods included hand searches of sources (e.g., journals, reference lists), search terms (i.e., early, applied, behavioral, research, literature), inclusion criteria (e.g., the field's applied dimension), and (d) challenges to their face and content validity. Our results were 36 articles published between 1959 and 1967 that we organized into 4 groups: 12 in 3 programs of research and 24 others. Our discussion addresses (a) limitations in our method (e.g., the completeness of our search), (b) challenges to the validity of our methods and results (e.g., convergent validity), and (c) priority claims about the field's founding. We conclude that the claims are irresolvable because identification of the founding publications depends significantly on methods and because the field's founding was an evolutionary process. We close with suggestions for future research. PMID:25729133

A Multivariate Methodological Workflow for the Analysis of FTIR Chemical Mapping Applied on Historic Paint Stratigraphies

PubMed Central

Sciutto, Giorgia; Oliveri, Paolo; Catelli, Emilio; Bonacini, Irene

2017-01-01

In the field of applied researches in heritage science, the use of multivariate approach is still quite limited and often chemometric results obtained are often underinterpreted. Within this scenario, the present paper is aimed at disseminating the use of suitable multivariate methodologies and proposes a procedural workflow applied on a representative group of case studies, of considerable importance for conservation purposes, as a sort of guideline on the processing and on the interpretation of this FTIR data. Initially, principal component analysis (PCA) is performed and the score values are converted into chemical maps. Successively, the brushing approach is applied, demonstrating its usefulness for a deep understanding of the relationships between the multivariate map and PC score space, as well as for the identification of the spectral bands mainly involved in the definition of each area localised within the score maps. PMID:29333162

Using nano- and micro-particles of silver in lignin analysis

Treesearch

Umesh P. Agarwal; Richard S. Reiner; Sally A. Ralph

2006-01-01

Although there are numerous techniques available to study lignin in its various states, they all have limitations and to extract most amount of information, a number of analytical techniques have to be jointly used. We have recently started applying a new approach to lignin analysis - namely using nano- and micro-particles of silver for study of native and residual...

40 CFR 60.5180 - Do the emission limits, emission standards, and operating limits apply during periods of startup...

Code of Federal Regulations, 2011 CFR

2011-07-01

... standards, and operating limits apply during periods of startup, shutdown, and malfunction? 60.5180 Section... startup, shutdown, and malfunction? The emission limits and standards apply at all times and during... concentration limit using CO CEMS, the correction to 7 percent oxygen does not apply during periods of startup...

40 CFR 60.5180 - Do the emission limits, emission standards, and operating limits apply during periods of startup...

Code of Federal Regulations, 2014 CFR

2014-07-01

... standards, and operating limits apply during periods of startup, shutdown, and malfunction? 60.5180 Section... startup, shutdown, and malfunction? The emission limits and standards apply at all times and during... concentration limit using CO CEMS, the correction to 7 percent oxygen does not apply during periods of startup...

40 CFR 60.5180 - Do the emission limits, emission standards, and operating limits apply during periods of startup...

Code of Federal Regulations, 2013 CFR

2013-07-01

... standards, and operating limits apply during periods of startup, shutdown, and malfunction? 60.5180 Section... startup, shutdown, and malfunction? The emission limits and standards apply at all times and during... concentration limit using CO CEMS, the correction to 7 percent oxygen does not apply during periods of startup...

40 CFR 60.5180 - Do the emission limits, emission standards, and operating limits apply during periods of startup...

Code of Federal Regulations, 2012 CFR

2012-07-01

... standards, and operating limits apply during periods of startup, shutdown, and malfunction? 60.5180 Section... startup, shutdown, and malfunction? The emission limits and standards apply at all times and during... concentration limit using CO CEMS, the correction to 7 percent oxygen does not apply during periods of startup...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Michal, V. P., E-mail: vincent.michal@cea.fr

The formalism for analyzing the magnetic field distribution in the vortex lattice of Pauli-limit heavy-electron superconductors is applied to the evaluation of the vortex lattice static linewidth relevant to the muon spin rotation ({mu}SR) experiment. Based on the Ginzburg-Landau expansion for the superconductor free energy, we study the evolution with respect to the external field of the static linewidth both in the limit of independent vortices (low magnetic field) with a variational expression for the order parameter and in the near H{sub c2}{sup P}(T) regime with an extension of the Abrikosov analysis to Pauli-limit superconductors. We conclude that in themore » Ginzburg-Landau regime in the Pauli-limit, anomalous variations of the static linewidth with the applied field are predicted as a result of the superconductor spin response around a vortex core that dominates the usual charge-response screening supercurrents. We propose the effect as a benchmark for studying new puzzling vortex lattice properties recently observed in CeCoIn{sub 5}.« less

Four photon parametric amplification. [in unbiased Josephson junction

NASA Technical Reports Server (NTRS)

Parrish, P. T.; Feldman, M. J.; Ohta, H.; Chiao, R. Y.

1974-01-01

An analysis is presented describing four-photon parametric amplification in an unbiased Josephson junction. Central to the theory is the model of the Josephson effect as a nonlinear inductance. Linear, small signal analysis is applied to the two-fluid model of the Josephson junction. The gain, gain-bandwidth product, high frequency limit, and effective noise temperature are calculated for a cavity reflection amplifier. The analysis is extended to multiple (series-connected) junctions and subharmonic pumping.

Best (but oft-forgotten) practices: mediation analysis.

PubMed

Fairchild, Amanda J; McDaniel, Heather L

2017-06-01

This contribution in the "Best (but Oft-Forgotten) Practices" series considers mediation analysis. A mediator (sometimes referred to as an intermediate variable, surrogate endpoint, or intermediate endpoint) is a third variable that explains how or why ≥2 other variables relate in a putative causal pathway. The current article discusses mediation analysis with the ultimate intention of helping nutrition researchers to clarify the rationale for examining mediation, avoid common pitfalls when using the model, and conduct well-informed analyses that can contribute to improving causal inference in evaluations of underlying mechanisms of effects on nutrition-related behavioral and health outcomes. We give specific attention to underevaluated limitations inherent in common approaches to mediation. In addition, we discuss how to conduct a power analysis for mediation models and offer an applied example to demonstrate mediation analysis. Finally, we provide an example write-up of mediation analysis results as a model for applied researchers. © 2017 American Society for Nutrition.

Best (but oft-forgotten) practices: mediation analysis12

PubMed Central

McDaniel, Heather L

2017-01-01

This contribution in the “Best (but Oft-Forgotten) Practices” series considers mediation analysis. A mediator (sometimes referred to as an intermediate variable, surrogate endpoint, or intermediate endpoint) is a third variable that explains how or why ≥2 other variables relate in a putative causal pathway. The current article discusses mediation analysis with the ultimate intention of helping nutrition researchers to clarify the rationale for examining mediation, avoid common pitfalls when using the model, and conduct well-informed analyses that can contribute to improving causal inference in evaluations of underlying mechanisms of effects on nutrition-related behavioral and health outcomes. We give specific attention to underevaluated limitations inherent in common approaches to mediation. In addition, we discuss how to conduct a power analysis for mediation models and offer an applied example to demonstrate mediation analysis. Finally, we provide an example write-up of mediation analysis results as a model for applied researchers. PMID:28446497

In sickness and in health: classmates are highly motivated to provide in-hospital support during childhood cancer therapy.

PubMed

Lindgren, Lea H; Schmiegelow, Kjeld; Helms, Anne Sofie; Thorsteinsson, Troels; Larsen, Hanne B

2017-01-01

Extended hospitalization for school-aged cancer patients increases their risk of social marginalization. School-aged children mature through peer-interaction, but healthcare providers fail to incorporate this in rehabilitation efforts. The RESPECT study offers classmates to cancer patients to become ambassadors during hospital stays. This study explores classmate decision-making patterns about ambassadorship. An open-ended question was prospectively and consecutively provided to classmates (N = 221) (and parents) of 10 children diagnosed with cancer in 2014 and enrolled in the RESPECT study. Statements were analysed using thematic content analysis. Of 221 classmates, 140 responded (63%). Of these, 81 applied for ambassadorship (median 8/patient), 58 declined, one was undecided. Nine forms were incomplete; leaving 131 in total that revealed 303 statements for analysis. Five major themes emerged: existing friendship (132/303 statements), personal resources (academic, emotional and social) (107/303), attitudes towards the ambassadorship (34/303), hospital environment (18/303) and logistics (12/303). Of the classmates with pre-existing friendships, 77% applied for ambassadorship and 80% with a surplus of personal resources applied. These were predominant predictors for ambassadorship application. Classmate motives were condensed into four archetypes: pre-existing friendship with a surplus of resources (100% applied), non-friend classmates with a surplus of resources (63% applied), pre-existing friendship with limited resources (22% applied) and non-friend classmates with limited resources (0% applied). Classmates are highly motivated to support patients during serious illness, irrespective of pre-existing friendships. Ambassadors offer a novel in-hospital approach to promote rehabilitation in children with severe/chronic diseases. Results need validation in other settings. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Prediction of turbulent shear layers in turbomachines

NASA Technical Reports Server (NTRS)

Bradshaw, P.

1974-01-01

The characteristics of turbulent shear layers in turbomachines are compared with the turbulent boundary layers on airfoils. Seven different aspects are examined. The limits of boundary layer theory are investigated. Boundary layer prediction methods are applied to analysis of the flow in turbomachines.

Evaluation of grid generation technologies from an applied perspective

NASA Technical Reports Server (NTRS)

Hufford, Gary S.; Harrand, Vincent J.; Patel, Bhavin C.; Mitchell, Curtis R.

1995-01-01

An analysis of the grid generation process from the point of view of an applied CFD engineer is given. Issues addressed include geometric modeling, structured grid generation, unstructured grid generation, hybrid grid generation and use of virtual parts libraries in large parametric analysis projects. The analysis is geared towards comparing the effective turn around time for specific grid generation and CFD projects. The conclusion was made that a single grid generation methodology is not universally suited for all CFD applications due to both limitations in grid generation and flow solver technology. A new geometric modeling and grid generation tool, CFD-GEOM, is introduced to effectively integrate the geometric modeling process to the various grid generation methodologies including structured, unstructured, and hybrid procedures. The full integration of the geometric modeling and grid generation allows implementation of extremely efficient updating procedures, a necessary requirement for large parametric analysis projects. The concept of using virtual parts libraries in conjunction with hybrid grids for large parametric analysis projects is also introduced to improve the efficiency of the applied CFD engineer.

Determination of trace arsenic on hanging copper amalgam drop electrode.

PubMed

Piech, Robert; Baś, Bogusław; Niewiara, Ewa; Kubiak, Władysław W

2007-04-30

Hanging copper amalgam drop electrode has been applied for trace determination of arsenic by cathodic stripping analysis. Detection limit for As(III) as low as 0.33nM (0.02mug/L) at deposition time (240s) could be obtained. For seven successive determinations of As(III) at concentration of 5nM relative standard deviation was 2.5% (n=7). Interferences from selected metals and surfactant substances were examined. Absence of copper ions in sample solution causes easier optimization and makes method less vulnerable on contamination. The developed method was validated by analysis of certified reference materials (CRMs) and applied to arsenic determinations in natural water samples.

Computational problems in autoregressive moving average (ARMA) models

NASA Technical Reports Server (NTRS)

Agarwal, G. C.; Goodarzi, S. M.; Oneill, W. D.; Gottlieb, G. L.

1981-01-01

The choice of the sampling interval and the selection of the order of the model in time series analysis are considered. Band limited (up to 15 Hz) random torque perturbations are applied to the human ankle joint. The applied torque input, the angular rotation output, and the electromyographic activity using surface electrodes from the extensor and flexor muscles of the ankle joint are recorded. Autoregressive moving average models are developed. A parameter constraining technique is applied to develop more reliable models. The asymptotic behavior of the system must be taken into account during parameter optimization to develop predictive models.

Fundamentals of Free-Space Optical Communications

NASA Technical Reports Server (NTRS)

Dolinar, Sam; Moision, Bruce; Erkmen, Baris

2012-01-01

Free-space optical communication systems potentially gain many dBs over RF systems. There is no upper limit on the theoretically achievable photon efficiency when the system is quantum-noise-limited: a) Intensity modulations plus photon counting can achieve arbitrarily high photon efficiency, but with sub-optimal spectral efficiency. b) Quantum-ideal number states can achieve the ultimate capacity in the limit of perfect transmissivity. Appropriate error correction codes are needed to communicate reliably near the capacity limits. Poisson-modeled noises, detector losses, and atmospheric effects must all be accounted for: a) Theoretical models are used to analyze performance degradations. b) Mitigation strategies derived from this analysis are applied to minimize these degradations.

40 CFR 63.11502 - What definitions apply to this subpart?

Code of Federal Regulations, 2013 CFR

2013-07-01

...: process knowledge, an engineering assessment, or test data. Byproduct means a chemical (liquid, gas, or... limit applicable to the process vent. (4) Design analysis based on accepted chemical engineering... (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Chemical Manufacturing Area Sources...

40 CFR 63.11502 - What definitions apply to this subpart?

Code of Federal Regulations, 2014 CFR

2014-07-01

...: process knowledge, an engineering assessment, or test data. Byproduct means a chemical (liquid, gas, or... limit applicable to the process vent. (4) Design analysis based on accepted chemical engineering... (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Chemical Manufacturing Area Sources...

Post-Newtonian Jeans Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nazari, Elham; Kazemi, Ali; Roshan, Mahmood

The Jeans analysis is studied in the first post-Newtonian limit. In other words, the relativistic effects on local gravitational instability are considered for systems whose characteristic velocities and corresponding gravitational fields are higher than those permitted in the Newtonian limit. The dispersion relation for the propagation of small perturbations is found in the post-Newtonian approximation using two different techniques. A new Jeans mass is derived and compared to the standard Jeans mass. In this limit, the relativistic effects make the new Jeans mass smaller than the Newtonian Jeans mass. Furthermore, the fractional difference between these two masses increases when themore » temperature/pressure of the system increases. Interestingly, in this limit, pressure can enhance gravitational instability instead of preventing it. Finally, the results are applied to high-temperature astrophysical systems, and the possibility of local fragmentation in some relativistic systems is investigated.« less

Determination of patulin in commercial apple juice by micellar electrokinetic chromatography.

PubMed

Murillo, M; González-Peñas, E; Amézqueta, S

2008-01-01

A novel and validated micellar electrokinetic capillary chromatography (MEKC) method using ultraviolet detection (UV) has been applied to the quantitative analysis of patulin (PAT) in commercial apple juice. Patulin was extracted from samples with an ethylacetate solution. The micellar electrokinetic capillary chromatography (MECK) parameters studied for method optimization were buffer composition, voltage, temperature, and a separation between PAT and 5-hydroxymethylfurfural (HMF) (main interference in apple juice PAT analysis) peaks until reaching baseline. The method passes a series of validation tests including selectivity, linearity, limit of detection and quantification (0.7 and 2.5 microgL(-1), respectively), precision (within and between-day variability) and recovery (80.2% RSD=4%), accuracy, and robustness. This method was successfully applied to the measurement of 20 apple juice samples obtained from different supermarkets. One hundred percent of the samples were contaminated with a level greater than the limit of detection, with mean and median values of 41.3 and 35.7 microgL(-1), respectively.

Coherent X-ray beam metrology using 2D high-resolution Fresnel-diffraction analysis.

PubMed

Ruiz-Lopez, M; Faenov, A; Pikuz, T; Ozaki, N; Mitrofanov, A; Albertazzi, B; Hartley, N; Matsuoka, T; Ochante, Y; Tange, Y; Yabuuchi, T; Habara, T; Tanaka, K A; Inubushi, Y; Yabashi, M; Nishikino, M; Kawachi, T; Pikuz, S; Ishikawa, T; Kodama, R; Bleiner, D

2017-01-01

Direct metrology of coherent short-wavelength beamlines is important for obtaining operational beam characteristics at the experimental site. However, since beam-time limitation imposes fast metrology procedures, a multi-parametric metrology from as low as a single shot is desirable. Here a two-dimensional (2D) procedure based on high-resolution Fresnel diffraction analysis is discussed and applied, which allowed an efficient and detailed beamline characterization at the SACLA XFEL. So far, the potential of Fresnel diffraction for beamline metrology has not been fully exploited because its high-frequency fringes could be only partly resolved with ordinary pixel-limited detectors. Using the high-spatial-frequency imaging capability of an irradiated LiF crystal, 2D information of the coherence degree, beam divergence and beam quality factor M 2 were retrieved from simple diffraction patterns. The developed beam metrology was validated with a laboratory reference laser, and then successfully applied at a beamline facility, in agreement with the source specifications.

Transfection microarray and the applications.

PubMed

Miyake, Masato; Yoshikawa, Tomohiro; Fujita, Satoshi; Miyake, Jun

2009-05-01

Microarray transfection has been extensively studied for high-throughput functional analysis of mammalian cells. However, control of efficiency and reproducibility are the critical issues for practical use. By using solid-phase transfection accelerators and nano-scaffold, we provide a highly efficient and reproducible microarray-transfection device, "transfection microarray". The device would be applied to the limited number of available primary cells and stem cells not only for large-scale functional analysis but also reporter-based time-lapse cellular event analysis.

Quantization error of CCD cameras and their influence on phase calculation in fringe pattern analysis.

PubMed

Skydan, Oleksandr A; Lilley, Francis; Lalor, Michael J; Burton, David R

2003-09-10

We present an investigation into the phase errors that occur in fringe pattern analysis that are caused by quantization effects. When acquisition devices with a limited value of camera bit depth are used, there are a limited number of quantization levels available to record the signal. This may adversely affect the recorded signal and adds a potential source of instrumental error to the measurement system. Quantization effects also determine the accuracy that may be achieved by acquisition devices in a measurement system. We used the Fourier fringe analysis measurement technique. However, the principles can be applied equally well for other phase measuring techniques to yield a phase error distribution that is caused by the camera bit depth.

High-throughput method for macrolides and lincosamides antibiotics residues analysis in milk and muscle using a simple liquid-liquid extraction technique and liquid chromatography-electrospray-tandem mass spectrometry analysis (LC-MS/MS).

PubMed

Jank, Louise; Martins, Magda Targa; Arsand, Juliana Bazzan; Campos Motta, Tanara Magalhães; Hoff, Rodrigo Barcellos; Barreto, Fabiano; Pizzolato, Tânia Mara

2015-11-01

A fast and simple method for residue analysis of the antibiotics classes of macrolides (erythromycin, azithromycin, tylosin, tilmicosin and spiramycin) and lincosamides (lincomycin and clindamycin) was developed and validated for cattle, swine and chicken muscle and for bovine milk. Sample preparation consists in a liquid-liquid extraction (LLE) with acetonitrile, followed by liquid chromatography-electrospray-tandem mass spectrometry analysis (LC-ESI-MS/MS), without the need of any additional clean-up steps. Chromatographic separation was achieved using a C18 column and a mobile phase composed by acidified acetonitrile and water. The method was fully validated according the criteria of the Commission Decision 2002/657/EC. Validation parameters such as limit of detection, limit of quantification, linearity, accuracy, repeatability, specificity, reproducibility, decision limit (CCα) and detection capability (CCβ) were evaluated. All calculated values met the established criteria. Reproducibility values, expressed as coefficient of variation, were all lower than 19.1%. Recoveries range from 60% to 107%. Limits of detection were from 5 to 25 µg kg(-1).The present method is able to be applied in routine analysis, with adequate time of analysis, low cost and a simple sample preparation protocol. Copyright © 2015. Published by Elsevier B.V.

One-step liquid-liquid extraction of cocaine from urine samples for gas chromatographic analysis.

PubMed

Farina, Marcelo; Yonamine, Maurício; Silva, Ovandir A

2002-07-17

An improved technique for cocaine extraction from urine samples for gas chromatographic (GC) analysis is described. Employing a simple liquid-liquid extraction (LLE) of cocaine with a mixture of ethyl ether:isopropanol (9:1) the method presents a mean recovery of 74.49%. Limit of detection (LOD) and limit of quantification (LOQ) were 5 and 20 ng/ml, respectively. The method is highly precise (coefficient of variation (CV) <8%) and linear from 20 to 2000 ng/ml. It can he applied to detect the presence of cocaine in urine as a marker of its recent use in drug abuse treatment protocols.

[Analysis of Arsenic Compounds in Blood and Urine by HPLC-ICP-MS].

PubMed

Lin, L; Zhang, S J; Xu, W C; Luo, R X; Ma, D; Shen, M

2018-02-01

To establish an analysis method for the detection of 6 arsenic compounds [AsC, AsB, As（Ⅲ）, DMA, MMA and As（V）] in blood and urine by high-performance liquid chromatography-inductively coupled plasma-mass spectrometry （HPLC-ICP-MS）, and apply it to real cases. Triton was used to damage cells, and then EDTA·2Na·2H2O was used to complex arsenic compounds in cells, and sonication and protein deposition by acetonitrile were performed for sample pretreatment. With the mobile phase consisted of ammonium carbonate and ultrapure water, gradient elution was performed for obtaining the arsenic compounds in samples, which were analysed by ICP-MS with Hamilton PRP-X100 column. The limits of detection in blood were 1.66-10 ng/mL, while the lower limits of quantitation in blood ranged from 5 to 30 ng/mL. The limits of detection in urine were 0.5-10 ng/mL, while the lower limits of quantitation in urine were 5-30 ng/mL. The relative standard deviation of inter-day and intra-day precisions was less than 10%. This method had been successfully applied to 3 cases. This study has established an analysis method for detecting 6 common arsenic compounds in blood and urine, which can be used to detect the arsenic compounds in the blood and urine from arsenic poisoning cases as well as the patients under arsenic treatment. Copyright© by the Editorial Department of Journal of Forensic Medicine.

Kernel-Phase Interferometry for Super-Resolution Detection of Faint Companions

NASA Astrophysics Data System (ADS)

Factor, Samuel

2016-10-01

Direct detection of close in companions (binary systems or exoplanets) is notoriously difficult. While chronagraphs and point spread function (PSF) subtraction can be used to reduce contrast and dig out signals of companions under the PSF, there are still significant limitations in separation and contrast. While non-redundant aperture masking (NRM) interferometry can be used to detect companions well inside the PSF of a diffraction limited image, the mask discards 95% of the light gathered by the telescope and thus the technique is severely flux limited. Kernel-phase analysis applies interferometric techniques similar to NRM though utilizing the full aperture. Instead of closure-phases, kernel-phases are constructed from a grid of points on the full aperture, simulating a redundant interferometer. I propose to develop my own faint companion detection pipeline which utilizes an MCMC analysis of kernel-phases. I will search for new companions in archival images from NIC1 and ACS/HRC in order to constrain binary and planet formation models at separations inaccessible to previous techniques. Using this method, it is possible to detect a companion well within the classical l/D Rayleigh diffraction limit using a fraction of the telescope time as NRM. This technique can easily be applied to archival data as no mask is needed and will thus make the detection of close in companions cheap and simple as no additional observations are needed. Since the James Webb Space Telescope (JWST) will be able to perform NRM observations, further development and characterization of kernel-phase analysis will allow efficient use of highly competitive JWST telescope time.

40 CFR 60.4860 - Do the emission limits, emission standards, and operating limits apply during periods of startup...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 7 2012-07-01 2012-07-01 false Do the emission limits, emission standards, and operating limits apply during periods of startup, shutdown, and malfunction? 60.4860 Section... emission limits, emission standards, and operating limits apply during periods of startup, shutdown, and...

40 CFR 60.4860 - Do the emission limits, emission standards, and operating limits apply during periods of startup...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 7 2013-07-01 2013-07-01 false Do the emission limits, emission standards, and operating limits apply during periods of startup, shutdown, and malfunction? 60.4860 Section... emission limits, emission standards, and operating limits apply during periods of startup, shutdown, and...

40 CFR 60.4860 - Do the emission limits, emission standards, and operating limits apply during periods of startup...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 6 2011-07-01 2011-07-01 false Do the emission limits, emission standards, and operating limits apply during periods of startup, shutdown, and malfunction? 60.4860 Section... emission limits, emission standards, and operating limits apply during periods of startup, shutdown, and...

40 CFR 60.4860 - Do the emission limits, emission standards, and operating limits apply during periods of startup...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 7 2014-07-01 2014-07-01 false Do the emission limits, emission standards, and operating limits apply during periods of startup, shutdown, and malfunction? 60.4860 Section... emission limits, emission standards, and operating limits apply during periods of startup, shutdown, and...

Stability and Bifurcation Analysis of a Three-Species Food Chain Model with Fear

NASA Astrophysics Data System (ADS)

Panday, Pijush; Pal, Nikhil; Samanta, Sudip; Chattopadhyay, Joydev

In the present paper, we investigate the impact of fear in a tri-trophic food chain model. We propose a three-species food chain model, where the growth rate of middle predator is reduced due to the cost of fear of top predator, and the growth rate of prey is suppressed due to the cost of fear of middle predator. Mathematical properties such as equilibrium analysis, stability analysis, bifurcation analysis and persistence have been investigated. We also describe the global stability analysis of the equilibrium points. Our numerical simulations reveal that cost of fear in basal prey may exhibit bistability by producing unstable limit cycles, however, fear in middle predator can replace unstable limit cycles by a stable limit cycle or a stable interior equilibrium. We observe that fear can stabilize the system from chaos to stable focus through the period-halving phenomenon. We conclude that chaotic dynamics can be controlled by the fear factors. We apply basic tools of nonlinear dynamics such as Poincaré section and maximum Lyapunov exponent to identify the chaotic behavior of the system.

Multiple Hypnotizabilities: Differentiating the Building Blocks of Hypnotic Response

ERIC Educational Resources Information Center

Woody, Erik Z.; Barnier, Amanda J.; McConkey, Kevin M.

2005-01-01

Although hypnotizability can be conceptualized as involving component subskills, standard measures do not differentiate them from a more general unitary trait, partly because the measures include limited sets of dichotomous items. To overcome this, the authors applied full-information factor analysis, a sophisticated analytic approach for…

Boolean network inference from time series data incorporating prior biological knowledge.

PubMed

Haider, Saad; Pal, Ranadip

2012-01-01

Numerous approaches exist for modeling of genetic regulatory networks (GRNs) but the low sampling rates often employed in biological studies prevents the inference of detailed models from experimental data. In this paper, we analyze the issues involved in estimating a model of a GRN from single cell line time series data with limited time points. We present an inference approach for a Boolean Network (BN) model of a GRN from limited transcriptomic or proteomic time series data based on prior biological knowledge of connectivity, constraints on attractor structure and robust design. We applied our inference approach to 6 time point transcriptomic data on Human Mammary Epithelial Cell line (HMEC) after application of Epidermal Growth Factor (EGF) and generated a BN with a plausible biological structure satisfying the data. We further defined and applied a similarity measure to compare synthetic BNs and BNs generated through the proposed approach constructed from transitions of various paths of the synthetic BNs. We have also compared the performance of our algorithm with two existing BN inference algorithms. Through theoretical analysis and simulations, we showed the rarity of arriving at a BN from limited time series data with plausible biological structure using random connectivity and absence of structure in data. The framework when applied to experimental data and data generated from synthetic BNs were able to estimate BNs with high similarity scores. Comparison with existing BN inference algorithms showed the better performance of our proposed algorithm for limited time series data. The proposed framework can also be applied to optimize the connectivity of a GRN from experimental data when the prior biological knowledge on regulators is limited or not unique.

Analysis of an Optical Channelization Technique for Microwave Applications

DTIC Science & Technology

2007-06-27

optical heterodyne RF signal generation using a mode- locked - laser frequency comb: theory and experiments,” in... optical carrier where +5 dBm RF tones at 9 GHz and 12 GHz were applied to the MZM biased at quadrature. The labels applied to this plot correspond to...Fig. 2 and Table I assuming ω1=2π· 9 GHz and ω2=2π·12 GHz . The laser -only spectrum illustrates the limitation set by the OSA. 7 -80 -60 -40 -20

Analysing attitude data through ridit schemes.

PubMed

El-rouby, M G

1994-12-02

The attitudes of individuals and populations on various issues are usually assessed through sample surveys. Responses to survey questions are then scaled and combined into a meaningful whole which defines the measured attitude. The applied scales may be of nominal, ordinal, interval, or ratio nature depending upon the degree of sophistication the researcher wants to introduce into the measurement. This paper discusses methods of analysis for categorical variables of the type used in attitude and human behavior research, and recommends adoption of ridit analysis, a technique which has been successfully applied to epidemiological, clinical investigation, laboratory, and microbiological data. The ridit methodology is described after reviewing some general attitude scaling methods and problems of analysis related to them. The ridit method is then applied to a recent study conducted to assess health care service quality in North Carolina. This technique is conceptually and computationally more simple than other conventional statistical methods, and is also distribution-free. Basic requirements and limitations on its use are indicated.

Think globally and solve locally: secondary memory-based network learning for automated multi-species function prediction

PubMed Central

2014-01-01

Background Network-based learning algorithms for automated function prediction (AFP) are negatively affected by the limited coverage of experimental data and limited a priori known functional annotations. As a consequence their application to model organisms is often restricted to well characterized biological processes and pathways, and their effectiveness with poorly annotated species is relatively limited. A possible solution to this problem might consist in the construction of big networks including multiple species, but this in turn poses challenging computational problems, due to the scalability limitations of existing algorithms and the main memory requirements induced by the construction of big networks. Distributed computation or the usage of big computers could in principle respond to these issues, but raises further algorithmic problems and require resources not satisfiable with simple off-the-shelf computers. Results We propose a novel framework for scalable network-based learning of multi-species protein functions based on both a local implementation of existing algorithms and the adoption of innovative technologies: we solve “locally” the AFP problem, by designing “vertex-centric” implementations of network-based algorithms, but we do not give up thinking “globally” by exploiting the overall topology of the network. This is made possible by the adoption of secondary memory-based technologies that allow the efficient use of the large memory available on disks, thus overcoming the main memory limitations of modern off-the-shelf computers. This approach has been applied to the analysis of a large multi-species network including more than 300 species of bacteria and to a network with more than 200,000 proteins belonging to 13 Eukaryotic species. To our knowledge this is the first work where secondary-memory based network analysis has been applied to multi-species function prediction using biological networks with hundreds of thousands of proteins. Conclusions The combination of these algorithmic and technological approaches makes feasible the analysis of large multi-species networks using ordinary computers with limited speed and primary memory, and in perspective could enable the analysis of huge networks (e.g. the whole proteomes available in SwissProt), using well-equipped stand-alone machines. PMID:24843788

Development and application of dynamic hybrid multi-region inventory analysis for macro-level environmental policy analysis: a case study on climate policy in Taiwan.

PubMed

Chao, Chia-Wei; Heijungs, Reinout; Ma, Hwong-wen

2013-03-19

We develop a novel inventory method called Dynamic Hybrid Multi-Region Inventory analysis (DHMRI), which integrates the EEMRIOA and Integrated Hybrid LCA and applies time-dependent environmental intervention information for inventory analysis. Consequently, DHMRI is able to quantify the change in the environmental footprint caused by a specific policy while taking structural changes and technological dynamics into consideration. DHMRI is applied to assess the change in the total CO2 emissions associated with the total final demand caused by the climate policy in Taiwan to demonstrate the practicality of this novel method. The evaluation reveals that the implementation of mitigation measures included in the existing climate policy, such as an enhancement in energy efficiency, promotion of renewable energy, and limitation of the growth of energy-intensive industries, will lead to a 28% increase in the total CO2 emissions and that the main driver is the export-oriented electronics industry. Moreover, a major increase in the total emissions is predicted to occur in Southeast Asia and China. The observations from the case study reveal that DHMRI is capable of overcoming the limitations of existing assessment tools at macro-level evaluation of environmental policies.

Simultaneous analysis of six aldehyde-DNA adducts in salivary DNA of nonsmokers and smokers using stable isotope dilution liquid chromatography electrospray ionization-tandem mass spectrometry.

PubMed

Li, Xiangyu; Liu, Lujuan; Wang, Hongjuan; Chen, Jian; Zhu, Beibei; Chen, Huan; Hou, Hongwei; Hu, Qingyuan

2017-08-15

A stable method, using isotope dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS), to simultaneously determine six aldehyde-DNA adducts was developed and applied to the analysis of human salivary DNA samples. The detection limit of these six DNA adducts was in the range of 0.006-0.014ng/mL and that of the quantification limit was 0.017-0.026ng/mL. The intra-day and inter-day precision of all aldehyde-DNA adducts was <10%. The analysis was completed within 25min. Additionally, a noninvasive technique was used to collect the DNA samples from human saliva. The new method was successfully applied for the analysis of salivary DNA of nonsmokers and smokers. Five aldehyde-DNA adducts were detected in both smoker and nonsmoker salivary DNA, while α-Acr-dG was not detected in all the samples. Among these detected DNA adducts, no significant differences were found between smoker and nonsmoker (p>0.05). This may due to the individual detoxifying differences or environmental and endogenous exposure. Our study provides a rapid and selective method to simultaneously detect six aldehyde-DNA adducts and to assess potential DNA damage induced by aldehydes. Copyright © 2017 Elsevier B.V. All rights reserved.

Best estimate plus uncertainty analysis of departure from nucleate boiling limiting case with CASL core simulator VERA-CS in response to PWR main steam line break event

DOE PAGES

Brown, Cameron S.; Zhang, Hongbin; Kucukboyaci, Vefa; ...

2016-09-07

VERA-CS (Virtual Environment for Reactor Applications, Core Simulator) is a coupled neutron transport and thermal-hydraulics subchannel code under development by the Consortium for Advanced Simulation of Light Water Reactors (CASL). VERA-CS was used to simulate a typical pressurized water reactor (PWR) full core response with 17x17 fuel assemblies for a main steam line break (MSLB) accident scenario with the most reactive rod cluster control assembly stuck out of the core. The accident scenario was initiated at the hot zero power (HZP) at the end of the first fuel cycle with return to power state points that were determined by amore » system analysis code and the most limiting state point was chosen for core analysis. The best estimate plus uncertainty (BEPU) analysis method was applied using Wilks’ nonparametric statistical approach. In this way, 59 full core simulations were performed to provide the minimum departure from nucleate boiling ratio (MDNBR) at the 95/95 (95% probability with 95% confidence level) tolerance limit. The results show that this typical PWR core remains within MDNBR safety limits for the MSLB accident.« less

Best estimate plus uncertainty analysis of departure from nucleate boiling limiting case with CASL core simulator VERA-CS in response to PWR main steam line break event

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, Cameron S.; Zhang, Hongbin; Kucukboyaci, Vefa

VERA-CS (Virtual Environment for Reactor Applications, Core Simulator) is a coupled neutron transport and thermal-hydraulics subchannel code under development by the Consortium for Advanced Simulation of Light Water Reactors (CASL). VERA-CS was used to simulate a typical pressurized water reactor (PWR) full core response with 17x17 fuel assemblies for a main steam line break (MSLB) accident scenario with the most reactive rod cluster control assembly stuck out of the core. The accident scenario was initiated at the hot zero power (HZP) at the end of the first fuel cycle with return to power state points that were determined by amore » system analysis code and the most limiting state point was chosen for core analysis. The best estimate plus uncertainty (BEPU) analysis method was applied using Wilks’ nonparametric statistical approach. In this way, 59 full core simulations were performed to provide the minimum departure from nucleate boiling ratio (MDNBR) at the 95/95 (95% probability with 95% confidence level) tolerance limit. The results show that this typical PWR core remains within MDNBR safety limits for the MSLB accident.« less

Surface temperatures and glassy state investigations in tribology, part 3. [limiting shear stress rheological model

NASA Technical Reports Server (NTRS)

Bair, S.; Winer, W. O.

1980-01-01

Research related to the development of the limiting shear stress rheological model is reported. Techniques were developed for subjecting lubricants to isothermal compression in order to obtain relevant determinations of the limiting shear stress and elastic shear modulus. The isothermal compression limiting shear stress was found to predict very well the maximum traction for a given lubricant. Small amounts of side slip and twist incorporated in the model were shown to have great influence on the rising portion of the traction curve at low slide-roll ratio. The shear rheological model was also applied to a Grubin-like elastohydrodynamic inlet analysis for predicting film thicknesses when employing the limiting shear stress model material behavior.

Polygenic risk score analysis of pathologically confirmed Alzheimer disease.

PubMed

Escott-Price, Valentina; Myers, Amanda J; Huentelman, Matt; Hardy, John

2017-08-01

Previous estimates of the utility of polygenic risk score analysis for the prediction of Alzheimer disease have given area under the curve (AUC) estimates of <80%. However, these have been based on the genetic analysis of clinical case-control series. Here, we apply the same analytic approaches to a pathological case-control series and show a predictive AUC of 84%. We suggest that this analysis has clinical utility and that there is limited room for further improvement using genetic data. Ann Neurol 2017;82:311-314. © 2017 American Neurological Association.

Tools and techniques for computational reproducibility.

PubMed

Piccolo, Stephen R; Frampton, Michael B

2016-07-11

When reporting research findings, scientists document the steps they followed so that others can verify and build upon the research. When those steps have been described in sufficient detail that others can retrace the steps and obtain similar results, the research is said to be reproducible. Computers play a vital role in many research disciplines and present both opportunities and challenges for reproducibility. Computers can be programmed to execute analysis tasks, and those programs can be repeated and shared with others. The deterministic nature of most computer programs means that the same analysis tasks, applied to the same data, will often produce the same outputs. However, in practice, computational findings often cannot be reproduced because of complexities in how software is packaged, installed, and executed-and because of limitations associated with how scientists document analysis steps. Many tools and techniques are available to help overcome these challenges; here we describe seven such strategies. With a broad scientific audience in mind, we describe the strengths and limitations of each approach, as well as the circumstances under which each might be applied. No single strategy is sufficient for every scenario; thus we emphasize that it is often useful to combine approaches.

Detection of explosives on the surface of banknotes by Raman hyperspectral imaging and independent component analysis.

PubMed

Almeida, Mariana R; Correa, Deleon N; Zacca, Jorge J; Logrado, Lucio Paulo Lima; Poppi, Ronei J

2015-02-20

The aim of this study was to develop a methodology using Raman hyperspectral imaging and chemometric methods for identification of pre- and post-blast explosive residues on banknote surfaces. The explosives studied were of military, commercial and propellant uses. After the acquisition of the hyperspectral imaging, independent component analysis (ICA) was applied to extract the pure spectra and the distribution of the corresponding image constituents. The performance of the methodology was evaluated by the explained variance and the lack of fit of the models, by comparing the ICA recovered spectra with the reference spectra using correlation coefficients and by the presence of rotational ambiguity in the ICA solutions. The methodology was applied to forensic samples to solve an automated teller machine explosion case. Independent component analysis proved to be a suitable method of resolving curves, achieving equivalent performance with the multivariate curve resolution with alternating least squares (MCR-ALS) method. At low concentrations, MCR-ALS presents some limitations, as it did not provide the correct solution. The detection limit of the methodology presented in this study was 50 μg cm(-2). Copyright © 2014 Elsevier B.V. All rights reserved.

MODIFYING EPA METHOD 314.0 FOR ANALYSIS OF PERCHLORATE IN AQUEOUS SAMPLES CONTAINING HIGH TOTAL DISSOLVED SOLIDS

EPA Science Inventory

Through the Regional Applied Research Effort (RARE) program, the Chemical Exposure Research Branch and Region 9 personnel in San Francisco, California are collaborating on a project to explore sample pretreatment and preconcentration techniques to lower the method detection limit...

40 CFR 63.2406 - What definitions apply to this subpart?

Code of Federal Regulations, 2014 CFR

2014-07-01

... average temperature of the stored organic liquid as determined from a design analysis of the storage tank.... Examples of containers include, but are not limited to, drums and portable cargo containers known as... transfer facilities to pipelines or any other forms of transportation. Design evaluation means a procedure...

40 CFR 63.2406 - What definitions apply to this subpart?

Code of Federal Regulations, 2013 CFR

2013-07-01

... average temperature of the stored organic liquid as determined from a design analysis of the storage tank.... Examples of containers include, but are not limited to, drums and portable cargo containers known as... transfer facilities to pipelines or any other forms of transportation. Design evaluation means a procedure...

Socioeconomic Status and Child Development: A Meta-Analysis

ERIC Educational Resources Information Center

Letourneau, Nicole Lyn; Duffett-Leger, Linda; Levac, Leah; Watson, Barry; Young-Morris, Catherine

2013-01-01

Lower socioeconomic status (SES) is widely accepted to have deleterious effects on the well-being and development of children and adolescents. However, rigorous meta-analytic methods have not been applied to determine the degree to which SES supports or limits children's and adolescents behavioural, cognitive and language development. While…

Film as a Lens for Teaching Culture: Balancing Concepts, Ambiguity, and Paradox.

ERIC Educational Resources Information Center

Mallinger, Mark; Rossy, Gerard

2003-01-01

Discusses how to apply dimensions of an integrated cultural framework (ability to influence, comfort with ambiguity, achievement orientation, individualism/collectivism, time orientation, space orientation) to analysis of films as part of the study of culture. Gives an application example and selection guidelines and discusses limitations. (SK)

DEAN: A Program for Dynamic Engine Analysis.

DTIC Science & Technology

1985-01-01

hardware and memory limitations. DIGTEM (ref. 4), a recently written code allows steady-state as well as transient calculations to be performed. DIGTEM has...Computer Program for Generating Dynamic Turbofan Engine Models ( DIGTEM )," NASA TM-83446. 5. Carnahan, B., Luther, H.A., and Wilkes, J.O., Applied Numerical

Development of Integrated Natural Science Teaching Materials Webbed Type with Applying Discourse Analysis on Students Grade VIII in Physics Class

NASA Astrophysics Data System (ADS)

Sukariasih, Luh

2017-05-01

This study aims to produce teaching materials integrated natural science (IPA) webbed type of handout types are eligible for use in integrated science teaching. This type of research IS a kind of research and development / Research and Development (R & D) with reference to the 4D development model that is (define, design, develop, and disseminate). Data analysis techniques used to process data from the results of the assessment by the validator expert, and the results of the assessment by teachers and learners while testing is limited (12 students of class VIII SMPN 10 Kendari) using quantitative descriptive data analysis techniques disclosed in the distribution of scores on the scale of five categories grading scale that has been determined. The results of due diligence material gain votes validator material in the category of “very good” and “good”, of the data generated in the feasibility test presentation obtained the category of “good” and “excellent”, from the data generated in the feasibility of graphic test obtained the category of “very good “and” good “, as well as of the data generated in the test the feasibility of using words and language obtained the category of“very good “and” good “, so with qualifications gained the teaching materials IPA integrated type webbed by applying discourse analysis on the theme of energy and food for Junior High School (SMP) grade VIII suitable as teaching materials. In limited testing, data generated in response to a science teacher at SMPN 10 Kendari to product instructional materials as “excellent”, and from the data generated while testing is limited by the 12 students of class VIII SMPN 10 Kendari are more students who score indicates category “very good”, so that the qualification obtained by the natural science (IPA) teaching material integrated type webbed by applying discourse analysis on the theme of energy and food for SMP / class VIII fit for use as teaching material.

Comparative advantages and limitations of the basic metrology methods applied to the characterization of nanomaterials.

PubMed

Linkov, Pavel; Artemyev, Mikhail; Efimov, Anton E; Nabiev, Igor

2013-10-07

Fabrication of modern nanomaterials and nanostructures with specific functional properties is both scientifically promising and commercially profitable. The preparation and use of nanomaterials require adequate methods for the control and characterization of their size, shape, chemical composition, crystalline structure, energy levels, pathways and dynamics of physical and chemical processes during their fabrication and further use. In this review, we discuss different instrumental methods for the analysis and metrology of materials and evaluate their advantages and limitations at the nanolevel.

Applied cognitive task analysis (ACTA): a practitioner's toolkit for understanding cognitive task demands.

PubMed

Militello, L G; Hutton, R J

1998-11-01

Cognitive task analysis (CTA) is a set of methods for identifying cognitive skills, or mental demands, needed to perform a task proficiently. The product of the task analysis can be used to inform the design of interfaces and training systems. However, CTA is resource intensive and has previously been of limited use to design practitioners. A streamlined method of CTA, Applied Cognitive Task Analysis (ACTA), is presented in this paper. ACTA consists of three interview methods that help the practitioner to extract information about the cognitive demands and skills required for a task. ACTA also allows the practitioner to represent this information in a format that will translate more directly into applied products, such as improved training scenarios or interface recommendations. This paper will describe the three methods, an evaluation study conducted to assess the usability and usefulness of the methods, and some directions for future research for making cognitive task analysis accessible to practitioners. ACTA techniques were found to be easy to use, flexible, and to provide clear output. The information and training materials developed based on ACTA interviews were found to be accurate and important for training purposes.

Thermodynamic Analysis of the Combustion of Metallic Materials

NASA Technical Reports Server (NTRS)

Wilson, D. Bruce; Stoltzfus, Joel M.

2000-01-01

Two types of computer codes are available to assist in the thermodynamic analysis of metallic materials combustion. One type of code calculates phase equilibrium data and is represented by CALPHAD. The other type of code calculates chemical reaction by the Gordon-McBride code. The first has seen significant application for alloy-phase diagrams, but only recently has it been considered for oxidation systems. The Gordon-McBride code has been applied to the combustion of metallic materials. Both codes are limited by their treatment of non-ideal solutions and the fact they are limited to treating volatile and gaseous species as ideal. This paper examines the significance of these limitations for combustion of metallic materials. In addition, the applicability of linear-free energy relationships for solid-phase oxidation and their possible extension to liquid-phase systems is examined.

Using contemporary liquid chromatography theory and technology to improve capillary gradient ion-exchange separations.

PubMed

Wouters, Bert; Broeckhoven, Ken; Wouters, Sam; Bruggink, Cees; Agroskin, Yury; Pohl, Christopher A; Eeltink, Sebastiaan

2014-11-28

The gradient-performance limits of capillary ion chromatography have been assessed at maximum system pressure (34.5 MPa) using capillary columns packed with 4.1 μm macroporous anion-exchange particles coated with 65 nm positively-charged nanobeads. In analogy to the van-Deemter curve, the gradient performance was assessed applying different flow rates, while decreasing the gradient time inversely proportional to the increase in flow rate in order to maintain the same retention properties. The gradient kinetic-performance limits were determined at maximum system pressure, applying tG/t0=5, 10, and 20. In addition, the effect of retention on peak width was assessed in gradient mode for mono-, di-, and trivalent inorganic anions. The peak width of late-eluting ions can be significantly reduced by using concave gradient, resulting in better detection sensitivity. A signal enhancement factor of 8 was measured for a late-eluting ion when applying a concave instead of a linear gradient. For the analysis of a complex anion mixture, a coupled column with a total length of 1.05 m was operated at the kinetic-performance limit applying a linear 250 min gradient (tG/t0=10). The peak capacity varied between 200 and 380 depending on analyte retention, and hence on charge and size of the ion. Copyright © 2014 Elsevier B.V. All rights reserved.

Earth resources mission performance studies. Volume 2: Simulation results

NASA Technical Reports Server (NTRS)

1974-01-01

Simulations were made at three month intervals to investigate the EOS mission performance over the four seasons of the year. The basic objectives of the study were: (1) to evaluate the ability of an EOS type system to meet a representative set of specific collection requirements, and (2) to understand the capabilities and limitations of the EOS that influence the system's ability to satisfy certain collection objectives. Although the results were obtained from a consideration of a two sensor EOS system, the analysis can be applied to any remote sensing system having similar optical and operational characteristics. While the category related results are applicable only to the specified requirement configuration, the results relating to general capability and limitations of the sensors can be applied in extrapolating to other U.S. based EOS collection requirements. The TRW general purpose mission simulator and analytic techniques discussed in this report can be applied to a wide range of collection and planning problems of earth orbiting imaging systems.

Statistical methods for astronomical data with upper limits. II - Correlation and regression

NASA Technical Reports Server (NTRS)

Isobe, T.; Feigelson, E. D.; Nelson, P. I.

1986-01-01

Statistical methods for calculating correlations and regressions in bivariate censored data where the dependent variable can have upper or lower limits are presented. Cox's regression and the generalization of Kendall's rank correlation coefficient provide significant levels of correlations, and the EM algorithm, under the assumption of normally distributed errors, and its nonparametric analog using the Kaplan-Meier estimator, give estimates for the slope of a regression line. Monte Carlo simulations demonstrate that survival analysis is reliable in determining correlations between luminosities at different bands. Survival analysis is applied to CO emission in infrared galaxies, X-ray emission in radio galaxies, H-alpha emission in cooling cluster cores, and radio emission in Seyfert galaxies.

The limits of direct satellite tracking with the Global Positioning System (GPS)

NASA Technical Reports Server (NTRS)

Bertiger, W. I.; Yunck, T. P.

1988-01-01

Recent advances in high precision differential Global Positioning System-based satellite tracking can be applied to the more conventional direct tracking of low earth satellites. To properly evaluate the limiting accuracy of direct GPS-based tracking, it is necessary to account for the correlations between the a-priori errors in GPS states, Y-bias, and solar pressure parameters. These can be obtained by careful analysis of the GPS orbit determination process. The analysis indicates that sub-meter accuracy can be readily achieved for a user above 1000 km altitude, even when the user solution is obtained with data taken 12 hours after the data used in the GPS orbit solutions.

Stereospecific analysis of sakuranetin by high-performance liquid chromatography: pharmacokinetic and botanical applications.

PubMed

Takemoto, Jody K; Remsberg, Connie M; Yáñez, Jaime A; Vega-Villa, Karina R; Davies, Neal M

2008-11-01

A stereospecific method for analysis of sakuranetin was developed. Separation was accomplished using a Chiralpak AD-RH column with UV (ultraviolet) detection at 288 nm. The stereospecific linear calibration curves ranged from 0.5 to 100 microg/mL. The mean extraction efficiency was >98%. Precision of the assay was <12% (relative standard deviation (R.S.D.)%), and within 10% at the limit of quantitation (0.5 microg/mL). Bias of the assay was lower than 10%, and within 5% at the limit of quantitation. The assay was applied successfully to pharmacokinetic quantification in rats, and the stereospecific quantification in oranges, grapefruit juice, and matico (Piper aduncum L.).

Perturbation solutions of combustion instability problems

NASA Technical Reports Server (NTRS)

Googerdy, A.; Peddieson, J., Jr.; Ventrice, M.

1979-01-01

A method involving approximate modal analysis using the Galerkin method followed by an approximate solution of the resulting modal-amplitude equations by the two-variable perturbation method (method of multiple scales) is applied to two problems of pressure-sensitive nonlinear combustion instability in liquid-fuel rocket motors. One problem exhibits self-coupled instability while the other exhibits mode-coupled instability. In both cases it is possible to carry out the entire linear stability analysis and significant portions of the nonlinear stability analysis in closed form. In the problem of self-coupled instability the nonlinear stability boundary and approximate forms of the limit-cycle amplitudes and growth and decay rates are determined in closed form while the exact limit-cycle amplitudes and growth and decay rates are found numerically. In the problem of mode-coupled instability the limit-cycle amplitudes are found in closed form while the growth and decay rates are found numerically. The behavior of the solutions found by the perturbation method are in agreement with solutions obtained using complex numerical methods.

Benefits and Limitations of Real Options Analysis for the Practice of River Flood Risk Management

NASA Astrophysics Data System (ADS)

Kind, Jarl M.; Baayen, Jorn H.; Botzen, W. J. Wouter

2018-04-01

Decisions on long-lived flood risk management (FRM) investments are complex because the future is uncertain. Flexibility and robustness can be used to deal with future uncertainty. Real options analysis (ROA) provides a welfare-economics framework to design and evaluate robust and flexible FRM strategies under risk or uncertainty. Although its potential benefits are large, ROA is hardly used in todays' FRM practice. In this paper, we investigate benefits and limitations of a ROA, by applying it to a realistic FRM case study for an entire river branch. We illustrate how ROA identifies optimal short-term investments and values future options. We develop robust dike investment strategies and value the flexibility offered by additional room for the river measures. We benchmark the results of ROA against those of a standard cost-benefit analysis and show ROA's potential policy implications. The ROA for a realistic case requires a high level of geographical detail, a large ensemble of scenarios, and the inclusion of stakeholders' preferences. We found several limitations of applying the ROA. It is complex. In particular, relevant sources of uncertainty need to be recognized, quantified, integrated, and discretized in scenarios, requiring subjective choices and expert judgment. Decision trees have to be generated and stakeholders' preferences have to be translated into decision rules. On basis of this study, we give general recommendations to use high discharge scenarios for the design of measures with high fixed costs and few alternatives. Lower scenarios may be used when alternatives offer future flexibility.

The balance sheet technique. Volume I. The balance sheet analysis technique for preconstruction review of airports and highways

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaBelle, S.J.; Smith, A.E.; Seymour, D.A.

1977-02-01

The technique applies equally well to new or existing airports. The importance of accurate accounting of emissions, cannot be overstated. The regional oxidant modelling technique used in conjunction with a balance sheet review must be a proportional reduction technique. This type of emission balancing presumes equality of all sources in the analysis region. The technique can be applied successfully in the highway context, either in planning at the system level or looking only at projects individually. The project-by-project reviews could be used to examine each project in the same way as the airport projects are examined for their impact onmore » regional desired emission levels. The primary limitation of this technique is that it should not be used when simulation models have been used for regional oxidant air quality. In the case of highway projects, the balance sheet technique might appear to be limited; the real limitations are in the transportation planning process. That planning process is not well-suited to the needs of air quality forecasting. If the transportation forecasting techniques are insensitive to change in the variables that affect HC emissions, then no internal emission trade-offs can be identified, and the initial highway emission forecasts are themselves suspect. In general, the balance sheet technique is limited by the quality of the data used in the review. Additionally, the technique does not point out effective trade-off strategies, nor does it indicate when it might be worthwhile to ignore small amounts of excess emissions. Used in the context of regional air quality plans based on proportional reduction models, the balance sheet analysis technique shows promise as a useful method by state or regional reviewing agencies.« less

76 FR 20732 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

... which a limit up/limit down mechanism to address extraordinary market volatility, if adopted, applies... mechanism to address extraordinary market volatility, if adopted, applies [April 11, 2011]. If the pilot is... limit up/limit down mechanism to address extraordinary market volatility, if adopted, applies [April 11...

Conducting high-value secondary dataset analysis: an introductory guide and resources.

PubMed

Smith, Alexander K; Ayanian, John Z; Covinsky, Kenneth E; Landon, Bruce E; McCarthy, Ellen P; Wee, Christina C; Steinman, Michael A

2011-08-01

Secondary analyses of large datasets provide a mechanism for researchers to address high impact questions that would otherwise be prohibitively expensive and time-consuming to study. This paper presents a guide to assist investigators interested in conducting secondary data analysis, including advice on the process of successful secondary data analysis as well as a brief summary of high-value datasets and online resources for researchers, including the SGIM dataset compendium ( www.sgim.org/go/datasets ). The same basic research principles that apply to primary data analysis apply to secondary data analysis, including the development of a clear and clinically relevant research question, study sample, appropriate measures, and a thoughtful analytic approach. A real-world case description illustrates key steps: (1) define your research topic and question; (2) select a dataset; (3) get to know your dataset; and (4) structure your analysis and presentation of findings in a way that is clinically meaningful. Secondary dataset analysis is a well-established methodology. Secondary analysis is particularly valuable for junior investigators, who have limited time and resources to demonstrate expertise and productivity.

Effective screening length of isotropic liquid samples submitted to an applied voltage.

PubMed

Zola, R S; Evangelista, L R; Barbero, G

2006-05-25

A cell of isotropic liquid in the shape of a slab of thickness d and containing ionic impurities is considered. It is shown that the screening effect produced by the ionic charges on the external field is characterized by an effective surface length, lambda(S)(U), depending on the applied voltage U. The analysis indicates that lambda(S)(U)) < lambda(D) when the applied voltage is very large, and lambda(S)(U) --> lambda(D) for very small values of the applied voltage, where lambda(D) is the Debye screening length. The presence of the ions is responsible also for a counterpotential, v, that for small U is such to cancel the effective electric field in the sample, whereas in the opposite limit it is inversely proportional to the applied difference of potential.

Limits on the mass, velocity and orbit of PSR J1933-6211

NASA Astrophysics Data System (ADS)

Graikou, E.; Verbiest, J. P. W.; Osłowski, S.; Champion, D. J.; Tauris, T. M.; Jankowski, F.; Kramer, M.

2017-11-01

We present a high-precision timing analysis of PSR J1933-6211, a millisecond pulsar with a 3.5 ms spin period and a white dwarf (WD) companion, using data from the Parkes radio telescope. Since we have accurately measured the polarization properties of this pulsar, we have applied the matrix template matching approach in which the times of arrival are measured using full polarimetric information. We achieved a weighted root-mean-square timing residuals of the timing residuals of 1.23 μs, 15.5 per cent improvement compared to the total intensity timing analysis. After studying the scintillation properties of this pulsar, we put constraints on the inclination angle of the system. Based on these measurements and on χ2 mapping we put a 2σ upper limit on the companion mass (0.44 M⊙). Since this mass limit cannot reveal the nature of the companion, we further investigate the possibility of the companion to be a He WD. Applying the orbital period-mass relation for such WDs, we conclude that the mass of a He WD companion would be about 0.26±0.01 M⊙, which combined with the measured mass function and orbital inclination limits, would lead to a light pulsar mass ≤ 1.0 M⊙. This result seems unlikely based on current neutron star formation models and we therefore conclude that PSR J1933-6211 most likely has a CO WD companion, which allows for a solution with a more massive pulsar.

Analysis of Elementary School Web Sites

ERIC Educational Resources Information Center

Hartshorne, Richard; Friedman, Adam; Algozzine, Bob; Kaur, Daljit

2008-01-01

While researchers have studied the use and value of educational software for many years, study of school Web sites and/or their effectiveness is limited. In this investigation, we identified goals and functions of school Web sites and used the foundations of effective Web site design to develop an evaluation checklist. We then applied these…

Comparative analysis of techniques for detection of quiescent Botrytis cinerea in grapes by quantitative PCR

USDA-ARS?s Scientific Manuscript database

Quantitative PCR (qPCR) can be used to detect and monitor pathogen colonization, but early attempts to apply the technology to quiescent Botrytis cinerea infections of grape berries identified some specific limitations. In this study, four DNA extraction methods, two tissue-grinding methods, two gra...

Domestic Work and the Wage Penalty for Motherhood in West Germany

ERIC Educational Resources Information Center

Kuhhirt, Michael; Ludwig, Volker

2012-01-01

Previous research suggests that household tasks prohibit women from unfolding their full earning potential by depleting their work effort and limiting their time flexibility. The present study investigated whether this relationship can explain the wage gap between mothers and nonmothers in West Germany. The empirical analysis applied fixed-effects…

Forest ecosystems of a Lower Gulf Coastal Plainlandscape: multifactor classification and analysis

Treesearch

P. Charles Goebel; Brian J. Palik; L. Katherine Kirkman; Mark B. Drew; Larry West; Dee C. Pederson

2001-01-01

The most common forestland classification techniques applied in the southeastern United States are vegetation-based. While not completely ignored, the application of multifactor, hierarchical ecosystem classifications are limited despite their widespread use in other regions of the eastern United States. We present one of the few truly integrated ecosystem...

Network analysis of mesoscale optical recordings to assess regional, functional connectivity.

PubMed

Lim, Diana H; LeDue, Jeffrey M; Murphy, Timothy H

2015-10-01

With modern optical imaging methods, it is possible to map structural and functional connectivity. Optical imaging studies that aim to describe large-scale neural connectivity often need to handle large and complex datasets. In order to interpret these datasets, new methods for analyzing structural and functional connectivity are being developed. Recently, network analysis, based on graph theory, has been used to describe and quantify brain connectivity in both experimental and clinical studies. We outline how to apply regional, functional network analysis to mesoscale optical imaging using voltage-sensitive-dye imaging and channelrhodopsin-2 stimulation in a mouse model. We include links to sample datasets and an analysis script. The analyses we employ can be applied to other types of fluorescence wide-field imaging, including genetically encoded calcium indicators, to assess network properties. We discuss the benefits and limitations of using network analysis for interpreting optical imaging data and define network properties that may be used to compare across preparations or other manipulations such as animal models of disease.

A review of machine learning in obesity.

PubMed

DeGregory, K W; Kuiper, P; DeSilvio, T; Pleuss, J D; Miller, R; Roginski, J W; Fisher, C B; Harness, D; Viswanath, S; Heymsfield, S B; Dungan, I; Thomas, D M

2018-05-01

Rich sources of obesity-related data arising from sensors, smartphone apps, electronic medical health records and insurance data can bring new insights for understanding, preventing and treating obesity. For such large datasets, machine learning provides sophisticated and elegant tools to describe, classify and predict obesity-related risks and outcomes. Here, we review machine learning methods that predict and/or classify such as linear and logistic regression, artificial neural networks, deep learning and decision tree analysis. We also review methods that describe and characterize data such as cluster analysis, principal component analysis, network science and topological data analysis. We introduce each method with a high-level overview followed by examples of successful applications. The algorithms were then applied to National Health and Nutrition Examination Survey to demonstrate methodology, utility and outcomes. The strengths and limitations of each method were also evaluated. This summary of machine learning algorithms provides a unique overview of the state of data analysis applied specifically to obesity. © 2018 World Obesity Federation.

The Effect of Drive Signal Limiting on High Cycle Fatigue Life Analysis

NASA Technical Reports Server (NTRS)

Kihm, Frederic; Rizzi, Stephen A.

2014-01-01

It is common practice to assume a Gaussian distribution of both the input acceleration and the response when modeling random vibration tests. In the laboratory, however, shaker controllers often limit the drive signal to prevent high amplitude peaks. The high amplitudes may either be truncated at a given level (socalled brick wall limiting or abrupt clipping), or compressed (soft limiting), resulting in drive signals which are no longer Gaussian. The paper first introduces several methods for limiting a drive signal, including brick wall limiting and compression. The limited signal is then passed through a linear time-invariant system representing a device under test. High cycle fatigue life predictions are subsequently made using spectral fatigue and rainflow cycle counting schemes. The life predictions are compared with those obtained from unclipped input signals. Some guidelines are provided to help the test engineer decide how clipping should be applied under different test scenarios.

Higher-Order Spectral Analysis of F-18 Flight Flutter Data

NASA Technical Reports Server (NTRS)

Silva, Walter A.; Dunn, Shane

2005-01-01

Royal Australian Air Force (RAAF) F/A-18 flight flutter test data is presented and analyzed using various techniques. The data includes high-quality measurements of forced responses and limit cycle oscillation (LCO) phenomena. Standard correlation and power spectral density (PSD) techniques are applied to the data and presented. Novel applications of experimentally-identified impulse responses and higher-order spectral techniques are also applied to the data and presented. The goal of this research is to develop methods that can identify the onset of nonlinear aeroelastic phenomena, such as LCO, during flutter testing.

Addiction Research Ethics and the Belmont Principles: Do Drug Users Have a Different Moral Voice?

PubMed Central

Fisher, Celia B.

2013-01-01

This study used semi-structured interviews and content analysis to examine moral principles that street drug users apply to three hypothetical addiction research ethical dilemmas. Participants (n = 90) were ethnically diverse, economically disadvantaged drug users recruited in New York City in 2009. Participants applied a wide range of contextually sensitive moral precepts, including respect, beneficence, justice, relationality, professional obligations, rules, and pragmatic self-interest. Limitations and implications for future research and the responsible conduct of addiction research are discussed. PMID:21073412

Systematic text condensation: a strategy for qualitative analysis.

PubMed

Malterud, Kirsti

2012-12-01

To present background, principles, and procedures for a strategy for qualitative analysis called systematic text condensation and discuss this approach compared with related strategies. Giorgi's psychological phenomenological analysis is the point of departure and inspiration for systematic text condensation. The basic elements of Giorgi's method and the elaboration of these in systematic text condensation are presented, followed by a detailed description of procedures for analysis according to systematic text condensation. Finally, similarities and differences compared with other frequently applied methods for qualitative analysis are identified, as the foundation of a discussion of strengths and limitations of systematic text condensation. Systematic text condensation is a descriptive and explorative method for thematic cross-case analysis of different types of qualitative data, such as interview studies, observational studies, and analysis of written texts. The method represents a pragmatic approach, although inspired by phenomenological ideas, and various theoretical frameworks can be applied. The procedure consists of the following steps: 1) total impression - from chaos to themes; 2) identifying and sorting meaning units - from themes to codes; 3) condensation - from code to meaning; 4) synthesizing - from condensation to descriptions and concepts. Similarities and differences comparing systematic text condensation with other frequently applied qualitative methods regarding thematic analysis, theoretical methodological framework, analysis procedures, and taxonomy are discussed. Systematic text condensation is a strategy for analysis developed from traditions shared by most of the methods for analysis of qualitative data. The method offers the novice researcher a process of intersubjectivity, reflexivity, and feasibility, while maintaining a responsible level of methodological rigour.

Application of ERTS-1 imagery to the study of caribou movements and winter dispersal in relation to prevailing snowcover

NASA Technical Reports Server (NTRS)

Lent, P. C. (Principal Investigator)

1973-01-01

The author has identified the following significant results. Step-wise discriminate analysis has demonstrated the feasibility of feature identification using linear discriminate functions of ERTS-1 MSS band densities and their ratios. The analysis indicated that features such as small streams can be detected even when they are in dark mountain shadow. The potential utility of this and similar analytic techniques appears considerable, and the limits it can be applied to analysis of ERTS-1 imagery are not yet fully known.

Rapid, direct extraction of DNA from soils for PCR analysis using polyvinylpolypyrrolidone spin columns.

PubMed

Berthelet, M; Whyte, L G; Greer, C W

1996-04-15

Polyvinylpolypyrrolidone spin columns were used to rapidly purify crude soil DNA extracts from humic materials for polymerase chain reaction (PCR) analysis. The PCR detection limit for the tfdC gene, encoding chlorocatechol dioxygenase from the 2,4-dichlorophenoxyacetic acid degradation pathway, was 10(1)-10(2) cells/g soil in inoculated soils. The procedure could be applied to the amplification of biodegradative genes from indigenous microbial populations from a wide variety of soil types, and the entire analysis could be performed within 8 h.

Three-stage stochastic pump: Another type of Onsager-Casimir symmetry and results far from equilibrium

NASA Astrophysics Data System (ADS)

Rosas, Alexandre; Van den Broeck, Christian; Lindenberg, Katja

2018-06-01

The stochastic thermodynamic analysis of a time-periodic single particle pump sequentially exposed to three thermochemical reservoirs is presented. The analysis provides explicit results for flux, thermodynamic force, entropy production, work, and heat. These results apply near equilibrium as well as far from equilibrium. In the linear response regime, a different type of Onsager-Casimir symmetry is uncovered. The Onsager matrix becomes symmetric in the limit of zero dissipation.

Lightweight Active Object Retrieval with Weak Classifiers.

PubMed

Czúni, László; Rashad, Metwally

2018-03-07

In the last few years, there has been a steadily growing interest in autonomous vehicles and robotic systems. While many of these agents are expected to have limited resources, these systems should be able to dynamically interact with other objects in their environment. We present an approach where lightweight sensory and processing techniques, requiring very limited memory and processing power, can be successfully applied to the task of object retrieval using sensors of different modalities. We use the Hough framework to fuse optical and orientation information of the different views of the objects. In the presented spatio-temporal perception technique, we apply active vision, where, based on the analysis of initial measurements, the direction of the next view is determined to increase the hit-rate of retrieval. The performance of the proposed methods is shown on three datasets loaded with heavy noise.

Lightweight Active Object Retrieval with Weak Classifiers

PubMed Central

2018-01-01

In the last few years, there has been a steadily growing interest in autonomous vehicles and robotic systems. While many of these agents are expected to have limited resources, these systems should be able to dynamically interact with other objects in their environment. We present an approach where lightweight sensory and processing techniques, requiring very limited memory and processing power, can be successfully applied to the task of object retrieval using sensors of different modalities. We use the Hough framework to fuse optical and orientation information of the different views of the objects. In the presented spatio-temporal perception technique, we apply active vision, where, based on the analysis of initial measurements, the direction of the next view is determined to increase the hit-rate of retrieval. The performance of the proposed methods is shown on three datasets loaded with heavy noise. PMID:29518902

Activist model of political party growth

NASA Astrophysics Data System (ADS)

Jeffs, Rebecca A.; Hayward, John; Roach, Paul A.; Wyburn, John

2016-01-01

The membership of British political parties has a direct influence on their political effectiveness. This paper applies the mathematics of epidemiology to the analysis of the growth and decline of such memberships. The party members are divided into activists and inactive members, where all activists influence the quality of party recruitment, but only a subset of activists recruit and thus govern numerical growth. The activists recruit for only a limited period, which acts as a restriction on further party growth. This Limited Activist model is applied to post-war and recent memberships of the Labour, Scottish National and Conservative parties. The model reproduces data trends, and relates realistically to historical narratives. It is concluded that the political parties analysed are not in danger of extinction but experience repeated periods of growth and decline in membership, albeit at lower numbers than in the past.

Development of parallel line analysis criteria for recombinant adenovirus potency assay and definition of a unit of potency.

PubMed

Ogawa, Yasushi; Fawaz, Farah; Reyes, Candice; Lai, Julie; Pungor, Erno

2007-01-01

Parameter settings of a parallel line analysis procedure were defined by applying statistical analysis procedures to the absorbance data from a cell-based potency bioassay for a recombinant adenovirus, Adenovirus 5 Fibroblast Growth Factor-4 (Ad5FGF-4). The parallel line analysis was performed with a commercially available software, PLA 1.2. The software performs Dixon outlier test on replicates of the absorbance data, performs linear regression analysis to define linear region of the absorbance data, and tests parallelism between the linear regions of standard and sample. Width of Fiducial limit, expressed as a percent of the measured potency, was developed as a criterion for rejection of the assay data and to significantly improve the reliability of the assay results. With the linear range-finding criteria of the software set to a minimum of 5 consecutive dilutions and best statistical outcome, and in combination with the Fiducial limit width acceptance criterion of <135%, 13% of the assay results were rejected. With these criteria applied, the assay was found to be linear over the range of 0.25 to 4 relative potency units, defined as the potency of the sample normalized to the potency of Ad5FGF-4 standard containing 6 x 10(6) adenovirus particles/mL. The overall precision of the assay was estimated to be 52%. Without the application of Fiducial limit width criterion, the assay results were not linear over the range, and an overall precision of 76% was calculated from the data. An absolute unit of potency for the assay was defined by using the parallel line analysis procedure as the amount of Ad5FGF-4 that results in an absorbance value that is 121% of the average absorbance readings of the wells containing cells not infected with the adenovirus.

20 CFR 672.510 - What cost limits apply to the use of YouthBuild program funds?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false What cost limits apply to the use of YouthBuild program funds? 672.510 Section 672.510 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION... Limitations § 672.510 What cost limits apply to the use of YouthBuild program funds? (a) Administrative costs...

Generic Degraded Congiguration Probability Analysis for DOE Codisposal Waste Package

DOE Office of Scientific and Technical Information (OSTI.GOV)

S.F.A. Deng; M. Saglam; L.J. Gratton

2001-05-23

In accordance with the technical work plan, ''Technical Work Plan For: Department of Energy Spent Nuclear Fuel Work Packages'' (CRWMS M&O 2000c), this Analysis/Model Report (AMR) is developed for the purpose of screening out degraded configurations for U.S. Department of Energy (DOE) spent nuclear fuel (SNF) types. It performs the degraded configuration parameter and probability evaluations of the overall methodology specified in the ''Disposal Criticality Analysis Methodology Topical Report'' (YMP 2000, Section 3) to qualifying configurations. Degradation analyses are performed to assess realizable parameter ranges and physical regimes for configurations. Probability calculations are then performed for configurations characterized by k{submore » eff} in excess of the Critical Limit (CL). The scope of this document is to develop a generic set of screening criteria or models to screen out degraded configurations having potential for exceeding a criticality limit. The developed screening criteria include arguments based on physical/chemical processes and probability calculations and apply to DOE SNF types when codisposed with the high-level waste (HLW) glass inside a waste package. The degradation takes place inside the waste package and is long after repository licensing has expired. The emphasis of this AMR is on degraded configuration screening and the probability analysis is one of the approaches used for screening. The intended use of the model is to apply the developed screening criteria to each DOE SNF type following the completion of the degraded mode criticality analysis internal to the waste package.« less

Applying behavior analysis to clinical problems: review and analysis of habit reversal.

PubMed Central

Miltenberger, R G; Fuqua, R W; Woods, D W

1998-01-01

This article provides a review and analysis of habit reversal, a multicomponent procedure developed by Azrin and Nunn (1973, 1974) for the treatment of nervous habits, tics, and stuttering. The article starts with a discussion of the behaviors treated with habit reversal, behavioral covariation among habits, and functional analysis and assessment of habits. Research on habit reversal and simplified versions of the procedure is then described. Next the article discusses the limitations of habit reversal and the evidence for its generality. The article concludes with an analysis of the behavioral processes involved in habit reversal and suggestions for future research. PMID:9757583

Visual analysis of mass cytometry data by hierarchical stochastic neighbour embedding reveals rare cell types.

PubMed

van Unen, Vincent; Höllt, Thomas; Pezzotti, Nicola; Li, Na; Reinders, Marcel J T; Eisemann, Elmar; Koning, Frits; Vilanova, Anna; Lelieveldt, Boudewijn P F

2017-11-23

Mass cytometry allows high-resolution dissection of the cellular composition of the immune system. However, the high-dimensionality, large size, and non-linear structure of the data poses considerable challenges for the data analysis. In particular, dimensionality reduction-based techniques like t-SNE offer single-cell resolution but are limited in the number of cells that can be analyzed. Here we introduce Hierarchical Stochastic Neighbor Embedding (HSNE) for the analysis of mass cytometry data sets. HSNE constructs a hierarchy of non-linear similarities that can be interactively explored with a stepwise increase in detail up to the single-cell level. We apply HSNE to a study on gastrointestinal disorders and three other available mass cytometry data sets. We find that HSNE efficiently replicates previous observations and identifies rare cell populations that were previously missed due to downsampling. Thus, HSNE removes the scalability limit of conventional t-SNE analysis, a feature that makes it highly suitable for the analysis of massive high-dimensional data sets.

Practical and quality-control aspects of multi-element analysis with quadrupole ICP-MS with special attention to urine and whole blood.

PubMed

De Boer, Jan L M; Ritsema, Rob; Piso, Sjoerd; Van Staden, Hans; Van Den Beld, Wilbert

2004-07-01

Two screening methods were developed for rapid analysis of a great number of urine and blood samples within the framework of an exposure check of the population after a firework explosion. A total of 56 elements was measured including major elements. Sample preparation consisted of simple dilution. Extensive quality controls were applied including element addition and the use of certified reference materials. Relevant results at levels similar to those found in the literature were obtained for Co, Ni, Cu, Zn, Sr, Cd, Sn, Sb, Ba, Tl, and Pb in urine and for the same elements except Ni, Sn, Sb, and Ba in blood. However, quadrupole ICP-MS has limitations, mainly related to spectral interferences, for the analysis of urine and blood, and these cause higher detection limits. The general aspects discussed in the paper give it wider applicability than just for analysis of blood and urine-it can for example be used in environmental analysis.

Liquid electrode plasma-optical emission spectrometry combined with solid-phase preconcentration for on-site analysis of lead.

PubMed

Barua, Suman; Rahman, Ismail M M; Alam, Iftakharul; Miyaguchi, Maho; Sawai, Hikaru; Maki, Teruya; Hasegawa, Hiroshi

2017-08-15

A relatively rapid and precise method is presented for the determination of lead in aqueous matrix. The method consists of analyte quantitation using the liquid electrode plasma-optical emission spectrometry (LEP-OES) coupled with selective separation/preconcentration by solid-phase extraction (SPE). The impact of operating variables on the retention of lead in SPEs such as pH, flow rate of the sample solution; type, volume, flow rate of the eluent; and matrix effects were investigated. Selective SPE-separation/preconcentration minimized the interfering effect due to manganese in solution and limitations in lead-detection in low-concentration samples by LEP-OES. The LEP-OES operating parameters such as the electrical conductivity of sample solution; applied voltage; on-time, off-time, pulse count for applied voltage; number of measurements; and matrix effects have also been optimized to obtain a distinct peak for the lead at λ max =405.8nm. The limit of detection (3σ) and the limit of quantification (10σ) for lead determination using the technique were found as 1.9 and 6.5ng mL -1 , respectively. The precision, as relative standard deviation, was lower than 5% at 0.1μg mL -1 Pb, and the preconcentration factor was found to be 187. The proposed method was applied to the analysis of lead contents in the natural aqueous matrix (recovery rate:>95%). The method accuracy was verified using certified reference material of wastewaters: SPS-WW1 and ERM-CA713. The results from LEP-OES were in good agreement with inductively coupled plasma optical emission spectrometry measurements of the same samples. The application of the method is rapid (≤5min, without preconcentration) with a reliable detection limit at trace levels. Copyright © 2017 Elsevier B.V. All rights reserved.

Analysis of formaldehyde and acrolein in the aqueous samples using a novel needle trap device containing nanoporous silica aerogel sorbent.

PubMed

Barkhordari, Abdullah; Azari, Mansour R; Zendehdel, Rezvan; Heidari, Mahmoud

2017-04-01

In this research, a needle trap device (NTD) packed with nanoporous silica aerogel as a sorbent was used as a new technique for sampling and analysis of formaldehyde and acrolein compounds in aqueous and urine samples. The obtained results were compared with those of the commercial sorbent Carboxen1000. Active sampling was used and a 21-G needle was applied for extraction of gas in the sample headspace. The optimization of experimental parameters like salt addition, temperature and desorption time was done and the performance of the NTD for the extraction of the compounds was evaluated. The optimum temperature and time of desorption were 280 °C and 2 min, respectively. The ranges of limit of detection, limit of quantification and relative standard deviation (RSD) were 0.01-0.03 μg L -1 , 0.03-0.1 μg L -1 and 2.8-7.3%, respectively. It was found that the NTD containing nanoporous silica aerogel had a better performance. Thus, this technique can be applied as an effective and reliable method for sampling and analysis of aldehyde compounds from different biological matrices like urine, exhalation and so on.

A New Method for Analyzing Near-Field Faraday Probe Data in Hall Thrusters

NASA Technical Reports Server (NTRS)

Huang, Wensheng; Shastry, Rohit; Herman, Daniel A.; Soulas, George C.; Kamhawi, Hani

2013-01-01

This paper presents a new method for analyzing near-field Faraday probe data obtained from Hall thrusters. Traditional methods spawned from far-field Faraday probe analysis rely on assumptions that are not applicable to near-field Faraday probe data. In particular, arbitrary choices for the point of origin and limits of integration have made interpretation of the results difficult. The new method, called iterative pathfinding, uses the evolution of the near-field plume with distance to provide feedback for determining the location of the point of origin. Although still susceptible to the choice of integration limits, this method presents a systematic approach to determining the origin point for calculating the divergence angle. The iterative pathfinding method is applied to near-field Faraday probe data taken in a previous study from the NASA-300M and NASA-457Mv2 Hall thrusters. Since these two thrusters use centrally mounted cathodes the current density associated with the cathode plume is removed before applying iterative pathfinding. A procedure is presented for removing the cathode plume. The results of the analysis are compared to far-field probe analysis results. This paper ends with checks on the validity of the new method and discussions on the implications of the results.

A New Method for Analyzing Near-Field Faraday Probe Data in Hall Thrusters

NASA Technical Reports Server (NTRS)

Huang, Wensheng; Shastry, Rohit; Herman, Daniel A.; Soulas, George C.; Kamhawi, Hani

2013-01-01

This paper presents a new method for analyzing near-field Faraday probe data obtained from Hall thrusters. Traditional methods spawned from far-field Faraday probe analysis rely on assumptions that are not applicable to near-field Faraday probe data. In particular, arbitrary choices for the point of origin and limits of integration have made interpretation of the results difficult. The new method, called iterative pathfinding, uses the evolution of the near-field plume with distance to provide feedback for determining the location of the point of origin. Although still susceptible to the choice of integration limits, this method presents a systematic approach to determining the origin point for calculating the divergence angle. The iterative pathfinding method is applied to near-field Faraday probe data taken in a previous study from the NASA-300M and NASA-457Mv2 Hall thrusters. Since these two thrusters use centrally mounted cathodes, the current density associated with the cathode plume is removed before applying iterative pathfinding. A procedure is presented for removing the cathode plume. The results of the analysis are compared to far-field probe analysis results. This paper ends with checks on the validity of the new method and discussions on the implications of the results.

A limiting analysis for edge effects in angle-ply laminates

NASA Technical Reports Server (NTRS)

Hsu, P. W.; Herakovich, C. T.

1976-01-01

A zeroth order solution for edge effects in angle ply composite laminates using perturbation techniques and a limiting free body approach was developed. The general method of solution for laminates is developed and then applied to the special case of a graphite/epoxy laminate. Interlaminar stress distributions are obtained as a function of the laminate thickness to width ratio h/b and compared to existing numerical results. The solution predicts stable, continuous stress distributions, determines finite maximum tensile interlaminar normal stress for two laminates, and provides mathematical evidence for singular interlaminar shear stresses.

Setting limits on Effective Field Theories: the case of Dark Matter

NASA Astrophysics Data System (ADS)

Pobbe, Federico; Wulzer, Andrea; Zanetti, Marco

2017-08-01

The usage of Effective Field Theories (EFT) for LHC new physics searches is receiving increasing attention. It is thus important to clarify all the aspects related with the applicability of the EFT formalism in the LHC environment, where the large available energy can produce reactions that overcome the maximal range of validity, i.e. the cutoff, of the theory. We show that this does not forbid to set rigorous limits on the EFT parameter space through a modified version of the ordinary binned likelihood hypothesis test, which we design and validate. Our limit-setting strategy can be carried on in its full-fledged form by the LHC experimental collaborations, or performed externally to the collaborations, through the Simplified Likelihood approach, by relying on certain approximations. We apply it to the recent CMS mono-jet analysis and derive limits on a Dark Matter (DM) EFT model. DM is selected as a case study because the limited reach on the DM production EFT Wilson coefficient and the structure of the theory suggests that the cutoff might be dangerously low, well within the LHC reach. However our strategy can also be applied, if needed, to EFT's parametrising the indirect effects of heavy new physics in the Electroweak and Higgs sectors.

Polarographic study on the presence of antibiotics in food.

PubMed

Bottari, Emilio; Colombi, Massimiliano; De Bernardis, Chiara; Festa, Maria Rosa; Rampino, Vittorio

2018-07-01

EU and Italian laws dealing for the presence of antibiotics or, more in general, drags in food established limits for different kinds of food. Suitable rules exist about the medical treatment of cattle in relation to the production of milk and meat. The adoption of a procedure to check the respect of the law limits is necessary. In this paper, the presence of different classes of antibiotics in milk and in homogenised meat is investigated. Generally, HPLC methods are applied for this purpose. In this paper, the application of polarographic analysis is studied and the results are compared with the chromatographic ones. The comparison is relative to all the phases of analysis including the sample preparation. The results show the advantage of the proposed procedure.

Improved limits on dark matter annihilation in the Sun with the 79-string IceCube detector and implications for supersymmetry

NASA Astrophysics Data System (ADS)

Aartsen, M. G.; Abraham, K.; Ackermann, M.; Adams, J.; Aguilar, J. A.; Ahlers, M.; Ahrens, M.; Altmann, D.; Anderson, T.; Ansseau, I.; Anton, G.; Archinger, M.; Arguelles, C.; Arlen, T. C.; Auffenberg, J.; Bai, X.; Barwick, S. W.; Baum, V.; Bay, R.; Beatty, J. J.; Becker Tjus, J.; Becker, K.-H.; Beiser, E.; BenZvi, S.; Berghaus, P.; Berley, D.; Bernardini, E.; Bernhard, A.; Besson, D. Z.; Binder, G.; Bindig, D.; Bissok, M.; Blaufuss, E.; Blumenthal, J.; Boersma, D. J.; Bohm, C.; Börner, M.; Bos, F.; Bose, D.; Böser, S.; Botner, O.; Braun, J.; Brayeur, L.; Bretz, H.-P.; Buzinsky, N.; Casey, J.; Casier, M.; Cheung, E.; Chirkin, D.; Christov, A.; Clark, K.; Classen, L.; Coenders, S.; Collin, G. H.; Conrad, J. M.; Cowen, D. F.; Cruz Silva, A. H.; Danninger, M.; Daughhetee, J.; Davis, J. C.; Day, M.; de André, J. P. A. M.; De Clercq, C.; del Pino Rosendo, E.; Dembinski, H.; De Ridder, S.; Desiati, P.; de Vries, K. D.; de Wasseige, G.; de With, M.; DeYoung, T.; Díaz-Vélez, J. C.; di Lorenzo, V.; Dumm, J. P.; Dunkman, M.; Eberhardt, B.; Edsjö, J.; Ehrhardt, T.; Eichmann, B.; Euler, S.; Evenson, P. A.; Fahey, S.; Fazely, A. R.; Feintzeig, J.; Felde, J.; Filimonov, K.; Finley, C.; Flis, S.; Fösig, C.-C.; Fuchs, T.; Gaisser, T. K.; Gaior, R.; Gallagher, J.; Gerhardt, L.; Ghorbani, K.; Gier, D.; Gladstone, L.; Glagla, M.; Glüsenkamp, T.; Goldschmidt, A.; Golup, G.; Gonzalez, J. G.; Góra, D.; Grant, D.; Griffith, Z.; Groß, A.; Ha, C.; Haack, C.; Haj Ismail, A.; Hallgren, A.; Halzen, F.; Hansen, E.; Hansmann, B.; Hanson, K.; Hebecker, D.; Heereman, D.; Helbing, K.; Hellauer, R.; Hickford, S.; Hignight, J.; Hill, G. C.; Hoffman, K. D.; Hoffmann, R.; Holzapfel, K.; Homeier, A.; Hoshina, K.; Huang, F.; Huber, M.; Huelsnitz, W.; Hulth, P. O.; Hultqvist, K.; In, S.; Ishihara, A.; Jacobi, E.; Japaridze, G. S.; Jeong, M.; Jero, K.; Jones, B. J. P.; Jurkovic, M.; Kappes, A.; Karg, T.; Karle, A.; Katz, U.; Kauer, M.; Keivani, A.; Kelley, J. L.; Kemp, J.; Kheirandish, A.; Kiryluk, J.; Klein, S. R.; Kohnen, G.; Koirala, R.; Kolanoski, H.; Konietz, R.; Köpke, L.; Kopper, C.; Kopper, S.; Koskinen, D. J.; Kowalski, M.; Krings, K.; Kroll, G.; Kroll, M.; Krückl, G.; Kunnen, J.; Kurahashi, N.; Kuwabara, T.; Labare, M.; Lanfranchi, J. L.; Larson, M. J.; Lesiak-Bzdak, M.; Leuermann, M.; Leuner, J.; Lu, L.; Lünemann, J.; Madsen, J.; Maggi, G.; Mahn, K. B. M.; Mandelartz, M.; Maruyama, R.; Mase, K.; Matis, H. S.; Maunu, R.; McNally, F.; Meagher, K.; Medici, M.; Meier, M.; Meli, A.; Menne, T.; Merino, G.; Meures, T.; Miarecki, S.; Middell, E.; Mohrmann, L.; Montaruli, T.; Morse, R.; Nahnhauer, R.; Naumann, U.; Neer, G.; Niederhausen, H.; Nowicki, S. C.; Nygren, D. R.; Obertacke Pollmann, A.; Olivas, A.; Omairat, A.; O'Murchadha, A.; Palczewski, T.; Pandya, H.; Pankova, D. V.; Paul, L.; Pepper, J. A.; Pérez de los Heros, C.; Pfendner, C.; Pieloth, D.; Pinat, E.; Posselt, J.; Price, P. B.; Przybylski, G. T.; Quinnan, M.; Raab, C.; Rädel, L.; Rameez, M.; Rawlins, K.; Reimann, R.; Relich, M.; Resconi, E.; Rhode, W.; Richman, M.; Richter, S.; Riedel, B.; Robertson, S.; Rongen, M.; Rott, C.; Ruhe, T.; Ryckbosch, D.; Sabbatini, L.; Sander, H.-G.; Sandrock, A.; Sandroos, J.; Sarkar, S.; Savage, C.; Schatto, K.; Schimp, M.; Schlunder, P.; Schmidt, T.; Schoenen, S.; Schöneberg, S.; Schönwald, A.; Schulte, L.; Schumacher, L.; Scott, P.; Seckel, D.; Seunarine, S.; Silverwood, H.; Soldin, D.; Song, M.; Spiczak, G. M.; Spiering, C.; Stahlberg, M.; Stamatikos, M.; Stanev, T.; Stasik, A.; Steuer, A.; Stezelberger, T.; Stokstad, R. G.; Stößl, A.; Ström, R.; Strotjohann, N. L.; Sullivan, G. W.; Sutherland, M.; Taavola, H.; Taboada, I.; Tatar, J.; Ter-Antonyan, S.; Terliuk, A.; Te{š}ić, G.; Tilav, S.; Toale, P. A.; Tobin, M. N.; Toscano, S.; Tosi, D.; Tselengidou, M.; Turcati, A.; Unger, E.; Usner, M.; Vallecorsa, S.; Vandenbroucke, J.; van Eijndhoven, N.; Vanheule, S.; van Santen, J.; Veenkamp, J.; Vehring, M.; Voge, M.; Vraeghe, M.; Walck, C.; Wallace, A.; Wallraff, M.; Wandkowsky, N.; Weaver, Ch.; Wendt, C.; Westerhoff, S.; Whelan, B. J.; Wiebe, K.; Wiebusch, C. H.; Wille, L.; Williams, D. R.; Wills, L.; Wissing, H.; Wolf, M.; Wood, T. R.; Woschnagg, K.; Xu, D. L.; Xu, X. W.; Xu, Y.; Yanez, J. P.; Yodh, G.; Yoshida, S.; Zoll, M.

2016-04-01

We present an improved event-level likelihood formalism for including neutrino telescope data in global fits to new physics. We derive limits on spin-dependent dark matter-proton scattering by employing the new formalism in a re-analysis of data from the 79-string IceCube search for dark matter annihilation in the Sun, including explicit energy information for each event. The new analysis excludes a number of models in the weak-scale minimal supersymmetric standard model (MSSM) for the first time. This work is accompanied by the public release of the 79-string IceCube data, as well as an associated computer code for applying the new likelihood to arbitrary dark matter models.

CBCT-based bone quality assessment: are Hounsfield units applicable?

PubMed Central

Jacobs, R; Singer, S R; Mupparapu, M

2015-01-01

CBCT is a widely applied imaging modality in dentistry. It enables the visualization of high-contrast structures of the oral region (bone, teeth, air cavities) at a high resolution. CBCT is now commonly used for the assessment of bone quality, primarily for pre-operative implant planning. Traditionally, bone quality parameters and classifications were primarily based on bone density, which could be estimated through the use of Hounsfield units derived from multidetector CT (MDCT) data sets. However, there are crucial differences between MDCT and CBCT, which complicates the use of quantitative gray values (GVs) for the latter. From experimental as well as clinical research, it can be seen that great variability of GVs can exist on CBCT images owing to various reasons that are inherently associated with this technique (i.e. the limited field size, relatively high amount of scattered radiation and limitations of currently applied reconstruction algorithms). Although attempts have been made to correct for GV variability, it can be postulated that the quantitative use of GVs in CBCT should be generally avoided at this time. In addition, recent research and clinical findings have shifted the paradigm of bone quality from a density-based analysis to a structural evaluation of the bone. The ever-improving image quality of CBCT allows it to display trabecular bone patterns, indicating that it may be possible to apply structural analysis methods that are commonly used in micro-CT and histology. PMID:25315442

Kernel-Phase Interferometry for Super-Resolution Detection of Faint Companions

NASA Astrophysics Data System (ADS)

Factor, Samuel M.; Kraus, Adam L.

2017-06-01

Direct detection of close in companions (exoplanets or binary systems) is notoriously difficult. While coronagraphs and point spread function (PSF) subtraction can be used to reduce contrast and dig out signals of companions under the PSF, there are still significant limitations in separation and contrast near λ/D. Non-redundant aperture masking (NRM) interferometry can be used to detect companions well inside the PSF of a diffraction limited image, though the mask discards ˜ 95% of the light gathered by the telescope and thus the technique is severely flux limited. Kernel-phase analysis applies interferometric techniques similar to NRM to a diffraction limited image utilizing the full aperture. Instead of non-redundant closure-phases, kernel-phases are constructed from a grid of points on the full aperture, simulating a redundant interferometer. I have developed a new, easy to use, faint companion detection pipeline which analyzes kernel-phases utilizing Bayesian model comparison. I demonstrate this pipeline on archival images from HST/NICMOS, searching for new companions in order to constrain binary formation models at separations inaccessible to previous techniques. Using this method, it is possible to detect a companion well within the classical λ/D Rayleigh diffraction limit using a fraction of the telescope time as NRM. Since the James Webb Space Telescope (JWST) will be able to perform NRM observations, further development and characterization of kernel-phase analysis will allow efficient use of highly competitive JWST telescope time. As no mask is needed, this technique can easily be applied to archival data and even target acquisition images (e.g. from JWST), making the detection of close in companions cheap and simple as no additional observations are needed.

Evaluation of methods for managing censored results when calculating the geometric mean.

PubMed

Mikkonen, Hannah G; Clarke, Bradley O; Dasika, Raghava; Wallis, Christian J; Reichman, Suzie M

2018-01-01

Currently, there are conflicting views on the best statistical methods for managing censored environmental data. The method commonly applied by environmental science researchers and professionals is to substitute half the limit of reporting for derivation of summary statistics. This approach has been criticised by some researchers, raising questions around the interpretation of historical scientific data. This study evaluated four complete soil datasets, at three levels of simulated censorship, to test the accuracy of a range of censored data management methods for calculation of the geometric mean. The methods assessed included removal of censored results, substitution of a fixed value (near zero, half the limit of reporting and the limit of reporting), substitution by nearest neighbour imputation, maximum likelihood estimation, regression on order substitution and Kaplan-Meier/survival analysis. This is the first time such a comprehensive range of censored data management methods have been applied to assess the accuracy of calculation of the geometric mean. The results of this study show that, for describing the geometric mean, the simple method of substitution of half the limit of reporting is comparable or more accurate than alternative censored data management methods, including nearest neighbour imputation methods. Copyright © 2017 Elsevier Ltd. All rights reserved.

An analytical approach to customer requirement information processing

NASA Astrophysics Data System (ADS)

Zhou, Zude; Xiao, Zheng; Liu, Quan; Ai, Qingsong

2013-11-01

'Customer requirements' (CRs) management is a key component of customer relationship management (CRM). By processing customer-focused information, CRs management plays an important role in enterprise systems (ESs). Although two main CRs analysis methods, quality function deployment (QFD) and Kano model, have been applied to many fields by many enterprises in the past several decades, the limitations such as complex processes and operations make them unsuitable for online businesses among small- and medium-sized enterprises (SMEs). Currently, most SMEs do not have the resources to implement QFD or Kano model. In this article, we propose a method named customer requirement information (CRI), which provides a simpler and easier way for SMEs to run CRs analysis. The proposed method analyses CRs from the perspective of information and applies mathematical methods to the analysis process. A detailed description of CRI's acquisition, classification and processing is provided.

Quantitative Schlieren analysis applied to holograms of crystals grown on Spacelab 3

NASA Technical Reports Server (NTRS)

Brooks, Howard L.

1986-01-01

In order to extract additional information about crystals grown in the microgravity environment of Spacelab, a quantitative schlieren analysis technique was developed for use in a Holography Ground System of the Fluid Experiment System. Utilizing the Unidex position controller, it was possible to measure deviation angles produced by refractive index gradients of 0.5 milliradians. Additionally, refractive index gradient maps for any recorded time during the crystal growth were drawn and used to create solute concentration maps for the environment around the crystal. The technique was applied to flight holograms of Cell 204 of the Fluid Experiment System that were recorded during the Spacelab 3 mission on STS 51B. A triglycine sulfate crystal was grown under isothermal conditions in the cell and the data gathered with the quantitative schlieren analysis technique is consistent with a diffusion limited growth process.

Advances in Molecular Rotational Spectroscopy for Applied Science

NASA Astrophysics Data System (ADS)

Harris, Brent; Fields, Shelby S.; Pulliam, Robin; Muckle, Matt; Neill, Justin L.

2017-06-01

Advances in chemical sensitivity and robust, solid-state designs for microwave/millimeter-wave instrumentation compel the expansion of molecular rotational spectroscopy as research tool into applied science. It is familiar to consider molecular rotational spectroscopy for air analysis. Those techniques for molecular rotational spectroscopy are included in our presentation of a more broad application space for materials analysis using Fourier Transform Molecular Rotational Resonance (FT-MRR) spectrometers. There are potentially transformative advantages for direct gas analysis of complex mixtures, determination of unknown evolved gases with parts per trillion detection limits in solid materials, and unambiguous chiral determination. The introduction of FT-MRR as an alternative detection principle for analytical chemistry has created a ripe research space for the development of new analytical methods and sampling equipment to fully enable FT-MRR. We present the current state of purpose-built FT-MRR instrumentation and the latest application measurements that make use of new sampling methods.

Revealing the Naturalization of Language and Literacy: The Common Sense of Text Complexity

ERIC Educational Resources Information Center

Newhouse, Erica H.

2017-01-01

This article illustrates the process and obstacles encountered when applying the Common Core's three-part model of determining text complexity to an urban literature text. This analysis revealed how the model privileges language and literacy practices that limit the range of texts used in classrooms through a process of naturalization and by…

Formative Evaluation of an ABA Outreach Training Program for Parents of Children with Autism in Remote Areas

ERIC Educational Resources Information Center

Heitzman-Powell, Linda S.; Buzhardt, Jay; Rusinko, Lisa C.; Miller, Todd M.

2014-01-01

Families in rural or remote areas have limited access to evidence-based intervention for their children with autism. Using web-based training and telemedicine technology, the current study investigated the feasibility of training seven parents to implement Applied Behavior Analysis (ABA) strategies with their children with autism. In this…

Teachers' Reports of Learning and Application to Pedagogy Based on Engagement in Collaborative Peer Video Analysis

ERIC Educational Resources Information Center

Christ, Tanya; Arya, Poonam; Chiu, Ming Ming

2014-01-01

Given international use of video-based reflective discussions in teacher education, and the limited knowledge about whether teachers apply learning from these discussions, we explored teachers' learning of new ideas about pedagogy and their self-reported application of this learning. Nine inservice and 48 preservice teachers participated in…

40 CFR 80.613 - What defenses apply to persons deemed liable for a violation of a prohibited act under this subpart?

Code of Federal Regulations, 2013 CFR

2013-07-01

..., transportation, storage, and analysis. (4) Survey plan design requirements. The proposed survey plan required... contractual agreement between the branded refiner or importer and the person designed to prevent such action... conditions and limitations set forth in this paragraph (e): (1) Independent survey association. To comply...

40 CFR 80.613 - What defenses apply to persons deemed liable for a violation of a prohibited act under this subpart?

Code of Federal Regulations, 2011 CFR

2011-07-01

..., including sample collection, transportation, storage, and analysis. (4) Survey plan design requirements. The... contractual agreement between the branded refiner or importer and the person designed to prevent such action... conditions and limitations set forth in this paragraph (e): (1) Independent survey association. To comply...

40 CFR 80.613 - What defenses apply to persons deemed liable for a violation of a prohibited act under this subpart?

Code of Federal Regulations, 2014 CFR

2014-07-01

..., transportation, storage, and analysis. (4) Survey plan design requirements. The proposed survey plan required... contractual agreement between the branded refiner or importer and the person designed to prevent such action... conditions and limitations set forth in this paragraph (e): (1) Independent survey association. To comply...

40 CFR 80.613 - What defenses apply to persons deemed liable for a violation of a prohibited act under this subpart?

Code of Federal Regulations, 2010 CFR

2010-07-01

..., including sample collection, transportation, storage, and analysis. (4) Survey plan design requirements. The... contractual agreement between the branded refiner or importer and the person designed to prevent such action... subject to the conditions and limitations set forth in this paragraph (e): (1) Independent survey...

40 CFR 80.613 - What defenses apply to persons deemed liable for a violation of a prohibited act under this subpart?

Code of Federal Regulations, 2012 CFR

2012-07-01

..., including sample collection, transportation, storage, and analysis. (4) Survey plan design requirements. The... contractual agreement between the branded refiner or importer and the person designed to prevent such action... conditions and limitations set forth in this paragraph (e): (1) Independent survey association. To comply...

Testing microdensitometric ability to determine Monterey pine urban tree stress

Treesearch

David J. Nowak; Joe R. McBride

1993-01-01

Microdensitometric analysis of aerial photographs has been used to quantify urban tree stress of deciduous species. A test of this procedure applied to Monterey pine indicates that variations in ground cover beneath urban trees among cities and variations in crown morphology among tree species can limit the ability of microdensitometry to quantify urban tree stress....

Reconceptualizing Early and Late Onset: A Life Course Analysis of Older Heroin Users

ERIC Educational Resources Information Center

Boeri, Miriam Williams; Sterk, Claire E.; Elifson, Kirk W.

2008-01-01

Purpose: Researchers' knowledge regarding older users of illicit drugs is limited despite the increasing numbers of users. In this article, we apply a life course perspective to gain a further understanding of older adult drug use, specifically contrasting early- and late-onset heroin users. Design and Methods: We collected qualitative data from…

How College Students Understand Their Self-Control Development: A Qualitative Analysis

ERIC Educational Resources Information Center

Cliburn Allen, Cara; Glanzer, Perry

2017-01-01

Recent research has shown the importance of the positive benefits of high-levels of self-control for both individuals and society. Yet, we know only a limited amount about how college students understand and apply self-control. This qualitative study examined how a national sample of 75 students defined self-control, whether or not they believed…

Structured-Exercise-Program (SEP): An Effective Training Approach to Key Healthcare Professionals

ERIC Educational Resources Information Center

Miazi, Mosharaf H.; Hossain, Taleb; Tiroyakgosi, C.

2014-01-01

Structured exercise program is an effective approach to technology dependent resource limited healthcare area for professional training. The result of a recently conducted data analysis revealed this. The aim of the study is to know the effectiveness of the applied approach that was designed to observe the level of adherence to newly adopted…

Silica-based ionic liquid coating for 96-blade system for extraction of aminoacids from complex matrixes.

PubMed

Mousavi, Fatemeh; Pawliszyn, Janusz

2013-11-25

1-Vinyl-3-octadecylimidazolium bromide ionic liquid [C18VIm]Br was prepared and used for the modification of mercaptopropyl-functionalized silica (Si-MPS) through surface radical chain-transfer addition. The synthesized octadecylimidazolium-modified silica (SiImC18) was characterized by thermogravimetric analysis (TGA), infrared spectroscopy (IR), (13)C NMR and (29)Si NMR spectroscopy and used as an extraction phase for the automated 96-blade solid phase microextraction (SPME) system with thin-film geometry using polyacrylonitrile (PAN) glue. The new proposed extraction phase was applied for extraction of aminoacids from grape pulp, and LC-MS-MS method was developed for separation of model compounds. Extraction efficiency, reusability, linearity, limit of detection, limit of quantitation and matrix effect were evaluated. The whole process of sample preparation for the proposed method requires 270min for 96 samples simultaneously (60min preconditioning, 90min extraction, 60min desorption and 60min for carryover step) using 96-blade SPME system. Inter-blade and intra-blade reproducibility were in the respective ranges of 5-13 and 3-10% relative standard deviation (RSD) for all model compounds. Limits of detection and quantitation of the proposed SPME-LC-MS/MS system for analysis of analytes were found to range from 0.1 to 1.0 and 0.5 to 3.0μgL(-1), respectively. Standard addition calibration was applied for quantitative analysis of aminoacids from grape juice and the results were validated with solvent extraction (SE) technique. Copyright © 2013 Elsevier B.V. All rights reserved.

Combining System Safety and Reliability to Ensure NASA CoNNeCT's Success

NASA Technical Reports Server (NTRS)

Havenhill, Maria; Fernandez, Rene; Zampino, Edward

2012-01-01

Hazard Analysis, Failure Modes and Effects Analysis (FMEA), the Limited-Life Items List (LLIL), and the Single Point Failure (SPF) List were applied by System Safety and Reliability engineers on NASA's Communications, Navigation, and Networking reConfigurable Testbed (CoNNeCT) Project. The integrated approach involving cross reviews of these reports by System Safety, Reliability, and Design engineers resulted in the mitigation of all identified hazards. The outcome was that the system met all the safety requirements it was required to meet.

Model-independent constraints on possible modifications of Newtonian gravity

NASA Technical Reports Server (NTRS)

Talmadge, C.; Berthias, J.-P.; Hellings, R. W.; Standish, E. M.

1988-01-01

New model-independent constraints on possible modifications of Newtonian gravity over solar-system distance scales are presented, and their implications discussed. The constraints arise from the analysis of various planetary astrometric data sets. The results of the model-independent analysis are then applied to set limits on a variation in the l/r-squared behavior of gravity, on possible Yukawa-type interactions with ranges of the order of planetary distance scales, and on a deviation from Newtonian gravity of the type discussed by Milgrom (1983).

Bridging the Marketing Gap: A Review of How to Think Like a Behavior Analyst: Understanding the Science That Can Change Your Life by Jon Bailey and Mary Burch

PubMed Central

Austin, Jennifer L; Marshall, Jason A

2008-01-01

The field of applied behavior analysis has suffered from a relative dearth of user-friendly books appropriate to a lay audience. Bailey and Burch's book fills this niche with a work that is both entertaining and informative. The book is reviewed in terms of the strengths and limitations of its content, as well as in the context of the importance of effective marketing of behavior analysis.

Nonlinear Analysis of Airfoil High-Intensity Gust Response Using a High-Order Prefactored Compact Code

NASA Technical Reports Server (NTRS)

Crivellini, A.; Golubev, V.; Mankbadi, R.; Scott, J. R.; Hixon, R.; Povinelli, L.; Kiraly, L. James (Technical Monitor)

2002-01-01

The nonlinear response of symmetric and loaded airfoils to an impinging vortical gust is investigated in the parametric space of gust dimension, intensity, and frequency. The study, which was designed to investigate the validity limits for a linear analysis, is implemented by applying a nonlinear high-order prefactored compact code and comparing results with linear solutions from the GUST3D frequency-domain solver. Both the unsteady aerodynamic and acoustic gust responses are examined.

Concluding Analysis of IR Measurements of Microbreaking and Whitecaps

DTIC Science & Technology

2004-09-30

Microbreaking and Whitecaps 5b. GRANT NUMBER N00014-02-1-0523 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER Andrew T. Jessup 5e. TASK NUMBER...LIMITATION OF 18. NUMBER 19a. NAME OF RESPONSIBLE PERSON a. REPORT b. ABSTRACT c. THIS PAGE ABSTRACT OF Andrew Jessup PAGES Unclassified Unclassified...N00014-02-0523 Concluding Analysis of IR Measurements of Microbreaking and Whitecaps 04 Apr 2002 through 30 Sep 2004 Andrew T. Jessup Applied Physics

A managerial accounting analysis of hospital costs.

PubMed Central

Frank, W G

1976-01-01

Variance analysis, an accounting technique, is applied to an eight-component model of hospital costs to determine the contribution each component makes to cost increases. The method is illustrated by application to data on total costs from 1950 to 1973 for all U.S. nongovernmental not-for-profit short-term general hospitals. The costs of a single hospital are analyzed and compared to the group costs. The potential uses and limitations of the method as a planning and research tool are discussed. PMID:965233

A managerial accounting analysis of hospital costs.

PubMed

Frank, W G

1976-01-01

Variance analysis, an accounting technique, is applied to an eight-component model of hospital costs to determine the contribution each component makes to cost increases. The method is illustrated by application to data on total costs from 1950 to 1973 for all U.S. nongovernmental not-for-profit short-term general hospitals. The costs of a single hospital are analyzed and compared to the group costs. The potential uses and limitations of the method as a planning and research tool are discussed.

Margin and sensitivity methods for security analysis of electric power systems

NASA Astrophysics Data System (ADS)

Greene, Scott L.

Reliable operation of large scale electric power networks requires that system voltages and currents stay within design limits. Operation beyond those limits can lead to equipment failures and blackouts. Security margins measure the amount by which system loads or power transfers can change before a security violation, such as an overloaded transmission line, is encountered. This thesis shows how to efficiently compute security margins defined by limiting events and instabilities, and the sensitivity of those margins with respect to assumptions, system parameters, operating policy, and transactions. Security margins to voltage collapse blackouts, oscillatory instability, generator limits, voltage constraints and line overloads are considered. The usefulness of computing the sensitivities of these margins with respect to interarea transfers, loading parameters, generator dispatch, transmission line parameters, and VAR support is established for networks as large as 1500 buses. The sensitivity formulas presented apply to a range of power system models. Conventional sensitivity formulas such as line distribution factors, outage distribution factors, participation factors and penalty factors are shown to be special cases of the general sensitivity formulas derived in this thesis. The sensitivity formulas readily accommodate sparse matrix techniques. Margin sensitivity methods are shown to work effectively for avoiding voltage collapse blackouts caused by either saddle node bifurcation of equilibria or immediate instability due to generator reactive power limits. Extremely fast contingency analysis for voltage collapse can be implemented with margin sensitivity based rankings. Interarea transfer can be limited by voltage limits, line limits, or voltage stability. The sensitivity formulas presented in this thesis apply to security margins defined by any limit criteria. A method to compute transfer margins by directly locating intermediate events reduces the total number of loadflow iterations required by each margin computation and provides sensitivity information at minimal additional cost. Estimates of the effect of simultaneous transfers on the transfer margins agree well with the exact computations for a network model derived from a portion of the U.S grid. The accuracy of the estimates over a useful range of conditions and the ease of obtaining the estimates suggest that the sensitivity computations will be of practical value.

Censoring approach to the detection limits in X-ray fluorescence analysis

NASA Astrophysics Data System (ADS)

Pajek, M.; Kubala-Kukuś, A.

2004-10-01

We demonstrate that the effect of detection limits in the X-ray fluorescence analysis (XRF), which limits the determination of very low concentrations of trace elements and results in appearance of the so-called "nondetects", can be accounted for using the statistical concept of censoring. More precisely, the results of such measurements can be viewed as the left random censored data, which can further be analyzed using the Kaplan-Meier method correcting the data for the presence of nondetects. Using this approach, the results of measured, detection limit censored concentrations can be interpreted in a nonparametric manner including the correction for the nondetects, i.e. the measurements in which the concentrations were found to be below the actual detection limits. Moreover, using the Monte Carlo simulation technique we show that by using the Kaplan-Meier approach the corrected mean concentrations for a population of the samples can be estimated within a few percent uncertainties with respect of the simulated, uncensored data. This practically means that the final uncertainties of estimated mean values are limited in fact by the number of studied samples and not by the correction procedure itself. The discussed random-left censoring approach was applied to analyze the XRF detection-limit-censored concentration measurements of trace elements in biomedical samples.

Continuously varying skin potentials elicited by sinusoidally varying electric shock potentials

NASA Technical Reports Server (NTRS)

Senders, J. W.; Senders, V. L.; Tursky, B.

1973-01-01

An investigation was carried out to determine whether a form of quasi-linear systems analysis can be applied to electrodormal responses to yield new insights into the nature of the response mechanisms and their interrelationships. The response investigated was the electrodermal response (galvanic skin potential, GSP) as elicited by an electric shock stimulus applied to the skin. The response subsequent to this stimulation was examined and its characteristics measured. A series of experimental runs on three Ss was accomplished, using sinusoidal modulation envelopes of frequencies. Results showed that it was possible to drive the GSP and to achieve relatively high coherence between the driving frequency and the response itself. The analysis was limited to Fourier analysis of the response in order to determine the relative energies at the driving frequency and at successive harmonics of that driving frequency, and correlational analysis in order to determine the degree of linear relationship between the driving frequency and the driven response.

The fundamental parameter method applied to X-ray fluorescence analysis with synchrotron radiation

NASA Astrophysics Data System (ADS)

Pantenburg, F. J.; Beier, T.; Hennrich, F.; Mommsen, H.

1992-05-01

Quantitative X-ray fluorescence analysis applying the fundamental parameter method is usually restricted to monochromatic excitation sources. It is shown here, that such analyses can be performed as well with a white synchrotron radiation spectrum. To determine absolute elemental concentration values it is necessary to know the spectral distribution of this spectrum. A newly designed and tested experimental setup, which uses the synchrotron radiation emitted from electrons in a bending magnet of ELSA (electron stretcher accelerator of the university of Bonn) is presented. The determination of the exciting spectrum, described by the given electron beam parameters, is limited due to uncertainties in the vertical electron beam size and divergence. We describe a method which allows us to determine the relative and absolute spectral distributions needed for accurate analysis. First test measurements of different alloys and standards of known composition demonstrate that it is possible to determine exact concentration values in bulk and trace element analysis.

The application of decision analysis to life support research and technology development

NASA Technical Reports Server (NTRS)

Ballin, Mark G.

1994-01-01

Applied research and technology development is often characterized by uncertainty, risk, and significant delays before tangible returns are obtained. Decision making regarding which technologies to advance and what resources to devote to them is a challenging but essential task. In the application of life support technology to future manned space flight, new technology concepts typically are characterized by nonexistent data and rough approximations of technology performance, uncertain future flight program needs, and a complex, time-intensive process to develop technology to a flight-ready status. Decision analysis is a quantitative, logic-based discipline that imposes formalism and structure to complex problems. It also accounts for the limits of knowledge that may be available at the time a decision is needed. The utility of decision analysis to life support technology R & D was evaluated by applying it to two case studies. The methodology was found to provide insight that is not possible from more traditional analysis approaches.

40 CFR 63.3490 - What emission limits must I meet?

Code of Federal Regulations, 2011 CFR

2011-07-01

... emissions to the atmosphere to no more than the emission limit(s) in Table 1 to this subpart that apply to... the atmosphere to no more than the limit(s) in Table 3 to this subpart, determined according to the... emissions to the atmosphere to no more than the emission limit(s) in Table 2 to this subpart that apply to...

40 CFR 63.3490 - What emission limits must I meet?

Code of Federal Regulations, 2010 CFR

2010-07-01

... emissions to the atmosphere to no more than the emission limit(s) in Table 1 to this subpart that apply to... the atmosphere to no more than the limit(s) in Table 3 to this subpart, determined according to the... emissions to the atmosphere to no more than the emission limit(s) in Table 2 to this subpart that apply to...

Utilizing a Robotic Sprayer for High Lateral and Mass Resolution MALDI FT-ICR MSI of Microbial Cultures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderton, Christopher R.; Chu, Rosalie K.; Tolic, Nikola

The ability to visualize biochemical interactions between microbial communities using MALDI MSI has provided tremendous insights into a variety of biological fields. Matrix application using a sieve proved to be incredibly useful, but it had many limitations that include uneven matrix coverage and limitation in the types of matrices one could employ in their studies. Recently, there has been a concerted effort to improve matrix application for studying agar plated microbial cultures, many of which utilized automated matrix sprayers. Here, we describe the usefulness of using a robotic sprayer for matrix application. The robotic sprayer has two-dimensional control over wheremore » matrix is applied and a heated capillary that allows for rapid drying of the applied matrix. This method provided a significant increase in MALDI sensitivity over the sieve method, as demonstrated by FT-ICR MS analysis, facilitating the ability to gain higher lateral resolution MS images of Bacillus Subtilis than previously reported. This method also allowed for the use of different matrices to be applied to the culture surfaces.« less

34 CFR 99.33 - What limitations apply to the redisclosure of information?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 1 2013-07-01 2013-07-01 false What limitations apply to the redisclosure of information? 99.33 Section 99.33 Education Office of the Secretary, Department of Education FAMILY EDUCATIONAL... From Education Records? § 99.33 What limitations apply to the redisclosure of information? (a)(1) An...

34 CFR 99.33 - What limitations apply to the redisclosure of information?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 1 2012-07-01 2012-07-01 false What limitations apply to the redisclosure of information? 99.33 Section 99.33 Education Office of the Secretary, Department of Education FAMILY EDUCATIONAL... From Education Records? § 99.33 What limitations apply to the redisclosure of information? (a)(1) An...

34 CFR 99.33 - What limitations apply to the redisclosure of information?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 1 2014-07-01 2014-07-01 false What limitations apply to the redisclosure of information? 99.33 Section 99.33 Education Office of the Secretary, Department of Education FAMILY EDUCATIONAL... From Education Records? § 99.33 What limitations apply to the redisclosure of information? (a)(1) An...

34 CFR 99.33 - What limitations apply to the redisclosure of information?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false What limitations apply to the redisclosure of information? 99.33 Section 99.33 Education Office of the Secretary, Department of Education FAMILY EDUCATIONAL... From Education Records? § 99.33 What limitations apply to the redisclosure of information? (a)(1) An...

34 CFR 99.33 - What limitations apply to the redisclosure of information?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 1 2011-07-01 2011-07-01 false What limitations apply to the redisclosure of information? 99.33 Section 99.33 Education Office of the Secretary, Department of Education FAMILY EDUCATIONAL... From Education Records? § 99.33 What limitations apply to the redisclosure of information? (a)(1) An...

A practical approach for linearity assessment of calibration curves under the International Union of Pure and Applied Chemistry (IUPAC) guidelines for an in-house validation of method of analysis.

PubMed

Sanagi, M Marsin; Nasir, Zalilah; Ling, Susie Lu; Hermawan, Dadan; Ibrahim, Wan Aini Wan; Naim, Ahmedy Abu

2010-01-01

Linearity assessment as required in method validation has always been subject to different interpretations and definitions by various guidelines and protocols. However, there are very limited applicable implementation procedures that can be followed by a laboratory chemist in assessing linearity. Thus, this work proposes a simple method for linearity assessment in method validation by a regression analysis that covers experimental design, estimation of the parameters, outlier treatment, and evaluation of the assumptions according to the International Union of Pure and Applied Chemistry guidelines. The suitability of this procedure was demonstrated by its application to an in-house validation for the determination of plasticizers in plastic food packaging by GC.

Ball bearing heat analysis program (BABHAP)

NASA Technical Reports Server (NTRS)

1978-01-01

The Ball Bearing Heat Analysis Program (BABHAP) is an attempt to assemble a series of equations, some of which are non-linear algebraic systems, in a logical order, which when solved, provide a complex analysis of load distribution among the balls, ball velocities, heat generation resulting from friction, applied load, and ball spinning, minimum lubricant film thickness, and many additional characteristics of ball bearing systems. Although initial design requirements for BABHAP were dictated by the core limitations of the PDP 11/45 computer, (approximately 8K of real words with limited number of instructions) the program dimensions can easily be expanded for large core computers such as the UNIVAC 1108. The PDP version of BABHAP is also operational on the UNIVAC system with the exception that the PDP uses 029 punch and the UNIVAC uses 026. A conversion program was written to allow transfer between machines.

Time-Distance Analysis of Deep Solar Convection

NASA Technical Reports Server (NTRS)

Duvall, T. L., Jr.; Hanasoge, S. M.

2011-01-01

Recently it was shown by Hanasoge, Duvall, and DeRosa (2010) that the upper limit to convective flows for spherical harmonic degrees l

A Bayesian hierarchical diffusion model decomposition of performance in Approach–Avoidance Tasks

PubMed Central

Krypotos, Angelos-Miltiadis; Beckers, Tom; Kindt, Merel; Wagenmakers, Eric-Jan

2015-01-01

Common methods for analysing response time (RT) tasks, frequently used across different disciplines of psychology, suffer from a number of limitations such as the failure to directly measure the underlying latent processes of interest and the inability to take into account the uncertainty associated with each individual's point estimate of performance. Here, we discuss a Bayesian hierarchical diffusion model and apply it to RT data. This model allows researchers to decompose performance into meaningful psychological processes and to account optimally for individual differences and commonalities, even with relatively sparse data. We highlight the advantages of the Bayesian hierarchical diffusion model decomposition by applying it to performance on Approach–Avoidance Tasks, widely used in the emotion and psychopathology literature. Model fits for two experimental data-sets demonstrate that the model performs well. The Bayesian hierarchical diffusion model overcomes important limitations of current analysis procedures and provides deeper insight in latent psychological processes of interest. PMID:25491372

Modeling of microjoule and millijoule energy LIDARs with PMT/SiPM/APD detectors: a sensitivity analysis.

PubMed

Agishev, Ravil

2018-05-10

This paper demonstrates a renewed concept and applications of the generalized methodology for atmospheric light detection and ranging (LIDAR) capability prediction as a continuation of a series of our previous works, where the dimensionless parameterization appeared as a tool for comparing systems of a different scale, design, and applications. The modernized concept applied to microscale and milliscale LIDARs with relatively new silicon photomultiplier detectors and traditional photomultiplier tube and avalanche photodiode detectors allowed prediction of the remote sensing instruments' performance and limitations. Such a generalized, uniform, and objective concept is applied for evaluation of the increasingly popular class of limited-energy LIDARs using the best optical detectors, operating on different targets (back-scatter or topographic, static or dynamic) and under intense sky background conditions. It can be used in the LIDAR community to compare different instruments and select the most suitable and effective ones for specific applications.

Rapid approach to identify the presence of Arabica and Robusta species in coffee using 1H NMR spectroscopy.

PubMed

Monakhova, Yulia B; Ruge, Winfried; Kuballa, Thomas; Ilse, Maren; Winkelmann, Ole; Diehl, Bernd; Thomas, Freddy; Lachenmeier, Dirk W

2015-09-01

NMR spectroscopy was used to verify the presence of Arabica and Robusta species in coffee. Lipophilic extracts of authentic roasted and green coffees showed the presence of established markers for Robusta (16-O-methylcafestol (16-OMC)) and for Arabica (kahweol). The integration of the 16-OMC signal (δ 3.165 ppm) was used to estimate the amount of Robusta in coffee blends with an approximate limit of detection of 1-3%. The method was successfully applied for the analysis of 77 commercial coffee samples (coffee pods, coffee capsules, and coffee beans). Furthermore, principal component analysis (PCA) was applied to the spectra of lipophilic and aqueous extracts of 20 monovarietal authentic samples. Clusters of the two species were observed. NMR spectroscopy can be used as a rapid prescreening tool to discriminate Arabica and Robusta coffee species before the confirmation applying the official method. Copyright © 2015 Elsevier Ltd. All rights reserved.

A comprehensive and scalable database search system for metaproteomics.

PubMed

Chatterjee, Sandip; Stupp, Gregory S; Park, Sung Kyu Robin; Ducom, Jean-Christophe; Yates, John R; Su, Andrew I; Wolan, Dennis W

2016-08-16

Mass spectrometry-based shotgun proteomics experiments rely on accurate matching of experimental spectra against a database of protein sequences. Existing computational analysis methods are limited in the size of their sequence databases, which severely restricts the proteomic sequencing depth and functional analysis of highly complex samples. The growing amount of public high-throughput sequencing data will only exacerbate this problem. We designed a broadly applicable metaproteomic analysis method (ComPIL) that addresses protein database size limitations. Our approach to overcome this significant limitation in metaproteomics was to design a scalable set of sequence databases assembled for optimal library querying speeds. ComPIL was integrated with a modified version of the search engine ProLuCID (termed "Blazmass") to permit rapid matching of experimental spectra. Proof-of-principle analysis of human HEK293 lysate with a ComPIL database derived from high-quality genomic libraries was able to detect nearly all of the same peptides as a search with a human database (~500x fewer peptides in the database), with a small reduction in sensitivity. We were also able to detect proteins from the adenovirus used to immortalize these cells. We applied our method to a set of healthy human gut microbiome proteomic samples and showed a substantial increase in the number of identified peptides and proteins compared to previous metaproteomic analyses, while retaining a high degree of protein identification accuracy and allowing for a more in-depth characterization of the functional landscape of the samples. The combination of ComPIL with Blazmass allows proteomic searches to be performed with database sizes much larger than previously possible. These large database searches can be applied to complex meta-samples with unknown composition or proteomic samples where unexpected proteins may be identified. The protein database, proteomic search engine, and the proteomic data files for the 5 microbiome samples characterized and discussed herein are open source and available for use and additional analysis.

Estimation of austral summer net community production in the Amundsen Sea: Self-organizing map analysis approach

NASA Astrophysics Data System (ADS)

Park, K.; Hahm, D.; Lee, D. G.; Rhee, T. S.; Kim, H. C.

2014-12-01

The Amundsen Sea, Antarctica, has been known for one of the most susceptible region to the current climate change such as sea ice melting and sea surface temperature change. In the Southern Ocean, a predominant amount of primary production is occurring in the continental shelf region. Phytoplankton blooms take place during the austral summer due to the limited sunlit and sea ice cover. Thus, quantifying the variation of summer season net community production (NCP) in the Amundsen Sea is essential to analyze the influence of climate change to the variation of biogeochemical cycle in the Southern Ocean. During the past three years of 2011, 2012 and 2014 in austral summer, we have conducted underway observations of ΔO2/Ar and derived NCP of the Amundsen Sea. Despite the importance of NCP for understanding biological carbon cycle of the ocean, the observations are rather limited to see the spatio-temporal variation in the Amundsen Sea. Therefore, we applied self-organizing map (SOM) analysis to expand our observed data sets and estimate the NCP during the summer season. SOM analysis, a type of artificial neural network, has been proved to be a useful method for extracting and classifying features in geoscience. In oceanography, SOM has applied for the analysis of various properties of the seawater such as sea surface temperature, chlorophyll concentration, pCO2, and NCP. Especially it is useful to expand a spatial coverage of direct measurements or to estimate properties whose satellite observations are technically or spatially limited. In this study, we estimate summer season NCP and find a variables set which optimally delineates the NCP variation in the Amundsen Sea as well. Moreover, we attempt to analyze the interannual variation of the Amundsen Sea NCP by taking climatological factors into account for the SOM analysis.

20 CFR 404.1343 - When the limits on granting World War II and post-World War II wage credits do not apply.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false When the limits on granting World War II and post-World War II wage credits do not apply. 404.1343 Section 404.1343 Employees' Benefits SOCIAL... When the limits on granting World War II and post-World War II wage credits do not apply. The limits on...

20 CFR 404.1343 - When the limits on granting World War II and post-World War II wage credits do not apply.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false When the limits on granting World War II and post-World War II wage credits do not apply. 404.1343 Section 404.1343 Employees' Benefits SOCIAL... When the limits on granting World War II and post-World War II wage credits do not apply. The limits on...

20 CFR 404.1343 - When the limits on granting World War II and post-World War II wage credits do not apply.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false When the limits on granting World War II and post-World War II wage credits do not apply. 404.1343 Section 404.1343 Employees' Benefits SOCIAL... When the limits on granting World War II and post-World War II wage credits do not apply. The limits on...

20 CFR 404.1343 - When the limits on granting World War II and post-World War II wage credits do not apply.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false When the limits on granting World War II and post-World War II wage credits do not apply. 404.1343 Section 404.1343 Employees' Benefits SOCIAL... When the limits on granting World War II and post-World War II wage credits do not apply. The limits on...

Forward Skirt Structural Testing on the Space Launch System (SLS) Program

NASA Technical Reports Server (NTRS)

Lohrer, J. D.; Wright, R. D.

2016-01-01

Structural testing was performed to evaluate heritage forward skirts from the Space Shuttle program for use on the Space Launch System (SLS) program. One forward skirt is located in each solid rocket booster. Heritage forward skirts are aluminum 2219 welded structures. Loads are applied at the forward skirt thrust post and ball assembly. Testing was needed because SLS ascent loads are roughly 40% higher than Space Shuttle loads. Testing objectives were to determine margins of safety, demonstrate reliability, and validate analytical models. Two forward skirts were structurally tested using the test configuration. The test stand applied loads to the thrust post. Four hydraulic actuators were used to apply axial load and two hydraulic actuators were used to apply radial and tangential loads. The first test was referred to as FSTA-1 (Forward Skirt Structural Test Article) and was performed in April/May 2014. The purpose of FSTA-1 was to verify the ultimate capability of the forward skirt subjected to ascent ultimate loads. Testing consisted of two liftoff load cases taken to 100% limit load followed by an ascent load case taken to 110% limit load. The forward skirt was unloaded to no load after each test case. Lastly, the forward skirt was tested to 140% limit and then to failure using the ascent loads. The second test was referred to as FSTA-2 and performed in July/August of 2014. The purpose of FSTA-2 was to verify the ultimate capability of the forward skirt subjected to liftoff ultimate loads. Testing consisted of six liftoff load cases taken to 100% limit load followed by the six liftoff cases taken to 140% limit load. Two ascent load cases were then tested to 100% limit load. The forward skirt was unloaded to no load after each test case. Lastly, the forward skirt was tested to 140% limit and then to failure using the ascent loads. The forward skirts on FSTA-1 and FSTA-2 successfully carried all applied liftoff and ascent load cases. Both FSTA-1 and FSTA-2 were tested to failure by increasing the ascent loads. Failure occurred in the forward skirt thrust post radius. The forward skirts on FSTA-1 and FSTA-2 had nearly identical failure modes. FSTA-1 failed at 1.72 times limit load and FSTA-2 failed at 1.62 times limit load. This difference is primarily attributed to variation in material properties in the thrust post region. Test data were obtained from strain gages, deflection gages, ARAMIS digital strain measurement, acoustic emissions, and high-speed video. Strain gage data and ARAMIS strain were compared to finite element (FE) analysis predictions. Both the forward skirt and tooling were modeled. This allows the analysis to simulate the loading as close as possible to actual test configuration. FSTA-1 and FSTA-2 were instrumented with over 200 strain gages to ensure all possible failure modes could be captured. However, it turned out that three gages provided critical strain data. One was located in the post bore and two on the post radius. More gages were not specified due to space limitations and the desire to not interfere with the use of the ARAMIS system on the post radius. Measured strains were compared to analysis results for the load cycle to failure. Note that FSTA-1 gages were lost before failure was reached. FSTA-2 gages made it to the failure load but one of the radius gages was lost before testing began. This gage was not replaced because of the time and cost associated with disassembly of the test structure. Correlation to analysis was excellent for FSTA-1. FSTA-2 was not quite as good because there was more residual strain from previous load cycles. FSTA-2 was loaded and unloaded with 12 liftoff cases and two ascent cases before taking the skirt to failure. FSTA-1 only had two liftoff cases and one ascent case before taking the skirt to failure. The ARAMIS system was used to determine strain at the post radius by processing digital images of a speckled paint pattern. Digital cameras recorded images of the speckled paint pattern. ARAMIS strain results for FSTA-2 just prior to failure. Note a high strain location develops near the left side. This high strain compares well to analysis prediction for both FSTA-1 and FSTA-2. The strain at this location was also plotted versus limit load. Both FSTA-1 and FSTA-2 had excellent correlation between ARAMIS and analysis strains. Acoustic emission (AE) sensors were used to monitor for damage formation that may occur during testing (e.g., crack formation and growth or propagation). AE was very important because after disassembly of FSTA-1, a crack was observed in the ball fitting radius. The ball fitting did not crack on FSTA-2. AE data was used to reconstruct when the crack occurred. The AE energy versus time plot for FSTA. The energy increased considerably at 850 seconds (152% limit load), indicating a crack could have formed at this point. The only visual evidence found that could have corresponded to this was the crack that initiated in the ball fitting. The cracks in the forward skirt aluminum structures would likely have been lower energy due to a lower modulus and all that were found after failure correlated to occurring after the initial crack in the post radius. This was verified by high-speed cameras used to record the failure.

Paper-based analytical devices for environmental analysis.

PubMed

Meredith, Nathan A; Quinn, Casey; Cate, David M; Reilly, Thomas H; Volckens, John; Henry, Charles S

2016-03-21

The field of paper-based microfluidics has experienced rapid growth over the past decade. Microfluidic paper-based analytical devices (μPADs), originally developed for point-of-care medical diagnostics in resource-limited settings, are now being applied in new areas, such as environmental analyses. Low-cost paper sensors show great promise for on-site environmental analysis; the theme of ongoing research complements existing instrumental techniques by providing high spatial and temporal resolution for environmental monitoring. This review highlights recent applications of μPADs for environmental analysis along with technical advances that may enable μPADs to be more widely implemented in field testing.

How GPs value guidelines applied to patients with multimorbidity: a qualitative study.

PubMed

Luijks, Hilde; Lucassen, Peter; van Weel, Chris; Loeffen, Maartje; Lagro-Janssen, Antoine; Schermer, Tjard

2015-10-26

To explore and describe the value general practitioner (GPs) attribute to medical guidelines when they are applied to patients with multimorbidity, and to describe which benefits GPs experience from guideline adherence in these patients. Also, we aimed to identify limitations from guideline adherence in patients with multimorbidity, as perceived by GPs, and to describe their empirical solutions to manage these obstacles. Focus group study with purposive sampling of participants. Focus groups were guided by an experienced moderator who used an interview guide. Interviews were transcribed verbatim. Data analysis was performed by two researchers using the constant comparison analysis technique and field notes were used in the analysis. Data collection proceeded until saturation was reached. Primary care, eastern part of The Netherlands. Dutch GPs, heterogeneous in age, sex and academic involvement. 25 GPs participated in five focus groups. GPs valued the guidance that guidelines provide, but experienced shortcomings when they were applied to patients with multimorbidity. Taking these patients' personal circumstances into account was regarded as important, but it was impeded by a consistent focus on guideline adherence. Preventative measures were considered less appropriate in (elderly) patients with multimorbidity. Moreover, the applicability of guidelines in patients with multimorbidity was questioned. GPs' extensive practical experience with managing multimorbidity resulted in several empirical solutions, for example, using their 'common sense' to respond to the perceived shortcomings. GPs applying guidelines for patients with multimorbidity integrate patient-specific factors in their medical decisions, aiming for patient-centred solutions. Such integration of clinical experience and best evidence is required to practise evidence-based medicine. More flexibility in pay-for-performance systems is needed to facilitate this integration. Several improvements in guideline reporting are necessary to enhance the applicability of guidelines in patients with multimorbidity. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Design and Analysis of Tooth Impact Test Rig for Spur Gear

NASA Astrophysics Data System (ADS)

Ghazali, Wafiuddin Bin Md; Aziz, Ismail Ali Bin Abdul; Daing Idris, Daing Mohamad Nafiz Bin; Ismail, Nurazima Binti; Sofian, Azizul Helmi Bin

2016-02-01

This paper is about the design and analysis of a prototype of tooth impact test rig for spur gear. The test rig was fabricated and analysis was conducted to study its’ limitation and capabilities. The design of the rig is analysed to ensure that there will be no problem occurring during the test and reliable data can be obtained. From the result of the analysis, the maximum amount of load that can be applied, the factor of safety of the machine, the stresses on the test rig parts were determined. This is important in the design consideration of the test rig. The materials used for the fabrication of the test rig were also discussed and analysed. MSC Nastran Patran software was used to analyse the model, which was designed by using SolidWorks 2014 software. Based from the results, there were limitations found from the initial design and the test rig design needs to be improved in order for the test rig to operate properly.

10 CFR 770.3 - What general limitations apply to this part?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false What general limitations apply to this part? 770.3 Section 770.3 Energy DEPARTMENT OF ENERGY TRANSFER OF REAL PROPERTY AT DEFENSE NUCLEAR FACILITIES FOR ECONOMIC DEVELOPMENT § 770.3 What general limitations apply to this part? (a) Nothing in this part affects or modifies...

10 CFR 770.3 - What general limitations apply to this part?

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false What general limitations apply to this part? 770.3 Section 770.3 Energy DEPARTMENT OF ENERGY TRANSFER OF REAL PROPERTY AT DEFENSE NUCLEAR FACILITIES FOR ECONOMIC DEVELOPMENT § 770.3 What general limitations apply to this part? (a) Nothing in this part affects or modifies...

10 CFR 770.3 - What general limitations apply to this part?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false What general limitations apply to this part? 770.3 Section 770.3 Energy DEPARTMENT OF ENERGY TRANSFER OF REAL PROPERTY AT DEFENSE NUCLEAR FACILITIES FOR ECONOMIC DEVELOPMENT § 770.3 What general limitations apply to this part? (a) Nothing in this part affects or modifies...

10 CFR 770.3 - What general limitations apply to this part?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false What general limitations apply to this part? 770.3 Section 770.3 Energy DEPARTMENT OF ENERGY TRANSFER OF REAL PROPERTY AT DEFENSE NUCLEAR FACILITIES FOR ECONOMIC DEVELOPMENT § 770.3 What general limitations apply to this part? (a) Nothing in this part affects or modifies...

10 CFR 770.3 - What general limitations apply to this part?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false What general limitations apply to this part? 770.3 Section 770.3 Energy DEPARTMENT OF ENERGY TRANSFER OF REAL PROPERTY AT DEFENSE NUCLEAR FACILITIES FOR ECONOMIC DEVELOPMENT § 770.3 What general limitations apply to this part? (a) Nothing in this part affects or modifies...

Development of chromatographic methods for the determination of genotoxic impurities in cloperastine fendizoate.

PubMed

García, Antonia; Rupérez, Francisco J; Ceppa, Florencia; Pellati, Federica; Barbas, Coral

2012-03-05

The classification of an impurity of a drug substance as genotoxic means that the "threshold of toxicological concern" (TTC) value of 1.5 μg/day intake, considered to be associated with an acceptable risk, should be the admissible limit in the raw material and that leads to new analytical challenges. In this study, reliable chromatographic methods were developed and applied as limit tests for the control of three genotoxic impurities (GTIs) in cloperastine fendizoate, drug widely used as an antitussive active pharmaceutical ingredient (API). In particular, GC-MS was applied to the determination of one alkyl halide (2-chloroethanol, 2-CE), while HPLC-DAD was selected for the analysis of two sulfonate esters (methyl p-toluenesulfonate, MPTS, and 2-chloroethyl p-toluenesulfonate, CEPTS). Regarding GC-MS, strong anion-exchange (SAX)-SPE was applied to remove fendizoate from the sample solutions, due its low volatility and its high amount in the raw material. The GC-MS analysis was performed on a Factor Four VF-23 ms capillary column (30 m × 0.25 mm I.D., film thickness 0.25 μm, Varian). Single ion-monitoring (SIM) detection mode was set at m/z 80. In the case of HPLC-DAD, a suitable optimization of the chromatographic conditions was carried out in order to obtain a good separation of the impurity peaks from the drug substance peaks. The optimized method utilizes a SymmetryShield RP(8) column (250 mm × 4.6 mm, 5 μm, Waters) kept at 50°C, with phosphate buffer (pH 3.0; 10 mM)-methanol (containing 10% ACN) (45:55, v/v) as the mobile phase, at the flow-rate of 1.7 mL/min and UV detection at 227 nm. The required sensitivity level was achieved by injecting 80 μL of sample solution, purified from fendizoate by SAX-SPE, followed by a 1:1 (v/v) dilution of the SPE eluate with water. For both GC-MS and HPLC-DAD, the method validation was performed in relation to specificity and limit of detection (LOD), as required by ICH guidelines in relation to limit assays. The developed methods were successfully applied for the determination of GTIs in five different batches of cloperastine fendizoate. In all the analyzed batches, the three target GTIs were below the concentration limit. Copyright © 2012 Elsevier B.V. All rights reserved.

Gabor filter for the segmentation of skin lesions from ultrasonographic images

NASA Astrophysics Data System (ADS)

Petrella, Lorena I.; Gómez, W.; Alvarenga, André V.; Pereira, Wagner C. A.

2012-05-01

The present work applies Gabor filters bank for texture analysis of skin lesions images, obtained by ultrasound biomicroscopy. The regions affected by the lesions were differentiated from surrounding tissue in all the analyzed cases; however the accuracy of the traced borders showed some limitations in part of the images. Future steps are being contemplated, attempting to enhance the technique performance.

Comparison of the Performance of Modal Control Schemes for an Adaptive Optics System and Analysis of the Effect of Actuator Limitations

DTIC Science & Technology

2012-06-01

the open-loop path is established, the feedback system can be treated as a set of SISO feedback loops and a single SISO control law can be applied...Zernike polynomials are commonly referred to by the names, such as focus, coma, astigmatism , and etc. Zernike polynomials can be transformed into

Design of advanced beams considering elasto-plastic behaviour of material

NASA Astrophysics Data System (ADS)

Tolun, S.

1992-10-01

The paper proposes a computational procedure for precise calculation of limit and ultimate or design loads, which must be carried by an advanced aviation beam, without permanent distortion and without rupture. Among several stress-strain curve representations, one that is suitable for a particular material is chosen for applied loads, yield, and failure load calculations, and then nonlinear analysis is performed.

Pre-Service Teachers: An Analysis of Reading Instruction in High Needs Districts Dual Language Classrooms

ERIC Educational Resources Information Center

Whitacre, Michael; Diaz, Zulmaris; Esquierdo, Joy

2013-01-01

Pre-service teachers need opportunities to apply theory and connect to best practices as they teach in classroom settings be it, whole or small group. For many pre-service teachers often times their experience is limited to simply watching instruction or working with small groups of students (Pryor & Kuhn, 2004). The student teaching…

Box compression analysis of world-wide data spanning 46 years

Treesearch

Thomas J. Urbanik; Benjamin Frank

2006-01-01

The state of the art among most industry citations of box compression estimation is the equation by McKee developed in 1963. Because of limitations in computing tools at the time the McKee equation was developed, the equation is a simplification, with many constraints, of a more general relationship. By applying the results of sophisticated finite element modeling, in...

78 FR 73739 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-09

...). SUMMARY: We propose to supersede Airworthiness Directives (ADs) 97-11- 07 and AD 99-18-23, which apply to all The Boeing Company Model MD-90- 30 airplanes. AD 97-11-07 and AD 99-18-23 currently require... for safe-life limited parts. Since we issued AD 97-11-07 and AD 99-18- 23, an analysis of data...

Recovering incomplete data using Statistical Multiple Imputations (SMI): a case study in environmental chemistry.

PubMed

Mercer, Theresa G; Frostick, Lynne E; Walmsley, Anthony D

2011-10-15

This paper presents a statistical technique that can be applied to environmental chemistry data where missing values and limit of detection levels prevent the application of statistics. A working example is taken from an environmental leaching study that was set up to determine if there were significant differences in levels of leached arsenic (As), chromium (Cr) and copper (Cu) between lysimeters containing preservative treated wood waste and those containing untreated wood. Fourteen lysimeters were setup and left in natural conditions for 21 weeks. The resultant leachate was analysed by ICP-OES to determine the As, Cr and Cu concentrations. However, due to the variation inherent in each lysimeter combined with the limits of detection offered by ICP-OES, the collected quantitative data was somewhat incomplete. Initial data analysis was hampered by the number of 'missing values' in the data. To recover the dataset, the statistical tool of Statistical Multiple Imputation (SMI) was applied, and the data was re-analysed successfully. It was demonstrated that using SMI did not affect the variance in the data, but facilitated analysis of the complete dataset. Copyright © 2011 Elsevier B.V. All rights reserved.

Controllability analysis and testing of a novel magnetorheological absorber for field gun recoil mitigation

NASA Astrophysics Data System (ADS)

Ouyang, Qing; Zheng, Jiajia; Li, Zhaochun; Hu, Ming; Wang, Jiong

2016-11-01

This paper aims to analyze the effects of combined working coils of magnetorheological (MR) absorber on the shock mitigation performance and verify the controllability of MR absorber as applied in the recoil system of a field gun. A physical scale model of the field gun is established and a long-stroke MR recoil absorber with four-stage parallel electromagnetic coils is designed to apply separate current to each stage and generate variable magnetic field distribution in the annular flow channel. Based on dynamic analysis and firing stability conditions of the field gun, ideal recoil force-stroke profiles of MR absorber at different limiting firing angles are obtained. The experimental studies are carried out on an impact test rig under different combinations of current loading: conventional unified control mode, separate control mode and timing control mode. The fullness degree index (FDI) is defined as the quantitative evaluation criterion of the controllability of MR absorber during the whole recoil motion. The results show that the force-stroke profile of the novel MR absorber can approach the ideal curve within 25 degrees of the limiting firing angle through judicious exploitation of the adjustable rheological properties of MR fluid.

DEM Modeling of a Flexible Barrier Impacted by a Dry Granular Flow

NASA Astrophysics Data System (ADS)

Albaba, Adel; Lambert, Stéphane; Kneib, François; Chareyre, Bruno; Nicot, François

2017-11-01

Flexible barriers are widely used as protection structures against natural hazards in mountainous regions, in particular for containing granular materials such as debris flows, snow avalanches and rock slides. This article presents a discrete element method-based model developed in the aim of investigating the response of flexible barriers in such contexts. It allows for accounting for the peculiar mechanical and geometrical characteristics of both the granular flow and the barrier in a same framework, and with limited assumptions. The model, developed with YADE software, is described in detail, as well as its calibration. In particular, cables are modeled as continuous bodies. Besides, it naturally considers the sliding of rings along supporting cables. The model is then applied for a generic flexible barrier to demonstrate its capacities in accounting for the behavior of different components. A detailed analysis of the forces in the different components showed that energy dissipators (ED) had limited influence on total force applied to the barrier and retaining capacity, but greatly influenced the load transmission within the barrier and the force in anchors. A sensitivity analysis showed that the barrier's response significantly changes according to the choice of ED activation force and incoming flow conditions.

Separation and determination of epinephrine and dopamine in traditional Chinese medicines by micellar electrokinetic capillary chromatography with laser induced fluorescence detection.

PubMed

Dong, Yuming; Chen, Hongli; Chen, Yonglei; Hui, Yang; Chen, Xingguo; Hu, Zhide

2006-08-01

A micellar electrokinetic capillary chromatography method with laser-induced fluorescence detection was developed for the analysis of epinephrine and dopamine after derivatization with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole. The optimum derivatization conditions were: 30 mM sodium borate (pH adjusted to 8.0 with 1.0 M HCl), reaction time 30 min at 60 degrees C. Baseline separation was achieved within 14 min with a running buffer composed of 10 mM sodium borate + 25 mM sodium dodecyl sulfate (pH adjusted to 9.5 with 0.1 M NaOH) and an applied voltage of 15 kV. Good linearity relationships (correlation coefficients: 0.9991 for epinephrine and 0.9985 for dopamine) between peak areas and concentrations of the analytes were obtained. The detection limits and quantification limits for epinephrine and dopamine were 0.0038 mg/L and 0.013 mg/L, and 0.065 mg/L and 0.020 mg/L, respectively. The method was applied to the analysis of the two compounds in two Chinese medicines with recoveries in the range of 92.6-108.7%.

Control analysis for autonomously oscillating biochemical networks.

PubMed Central

Reijenga, Karin A; Westerhoff, Hans V; Kholodenko, Boris N; Snoep, Jacky L

2002-01-01

It has hitherto not been possible to analyze the control of oscillatory dynamic cellular processes in other than qualitative ways. The control coefficients, used in metabolic control analyses of steady states, cannot be applied directly to dynamic systems. We here illustrate a way out of this limitation that uses Fourier transforms to convert the time domain into the stationary frequency domain, and then analyses the control of limit cycle oscillations. In addition to the already known summation theorems for frequency and amplitude, we reveal summation theorems that apply to the control of average value, waveform, and phase differences of the oscillations. The approach is made fully operational in an analysis of yeast glycolytic oscillations. It follows an experimental approach, sampling from the model output and using discrete Fourier transforms of this data set. It quantifies the control of various aspects of the oscillations by the external glucose concentration and by various internal molecular processes. We show that the control of various oscillatory properties is distributed over the system enzymes in ways that differ among those properties. The models that are described in this paper can be accessed on http://jjj.biochem.sun.ac.za. PMID:11751299

New Insights into Signed Path Coefficient Granger Causality Analysis.

PubMed

Zhang, Jian; Li, Chong; Jiang, Tianzi

2016-01-01

Granger causality analysis, as a time series analysis technique derived from econometrics, has been applied in an ever-increasing number of publications in the field of neuroscience, including fMRI, EEG/MEG, and fNIRS. The present study mainly focuses on the validity of "signed path coefficient Granger causality," a Granger-causality-derived analysis method that has been adopted by many fMRI researches in the last few years. This method generally estimates the causality effect among the time series by an order-1 autoregression, and defines a positive or negative coefficient as an "excitatory" or "inhibitory" influence. In the current work we conducted a series of computations from resting-state fMRI data and simulation experiments to illustrate the signed path coefficient method was flawed and untenable, due to the fact that the autoregressive coefficients were not always consistent with the real causal relationships and this would inevitablely lead to erroneous conclusions. Overall our findings suggested that the applicability of this kind of causality analysis was rather limited, hence researchers should be more cautious in applying the signed path coefficient Granger causality to fMRI data to avoid misinterpretation.

Decision-making in crisis: Applying a healthcare triage methodology to business continuity management.

PubMed

Moore, Bethany; Bone, Eric A

2017-01-01

The concept of triage in healthcare has been around for centuries and continues to be applied today so that scarce resources are allocated according to need. A business impact analysis (BIA) is a form of triage in that it identifies which processes are most critical, which to address first and how to allocate limited resources. On its own, however, the BIA provides only a roadmap of the impacts and interdependencies of an event. When disaster strikes, organisational decision-makers often face difficult decisions with regard to allocating limited resources between multiple 'mission-critical' functions. Applying the concept of triage to business continuity provides those decision-makers navigating a rapidly evolving and unpredictable event with a path that protects the fundamental priorities of the organisation. A business triage methodology aids decision-makers in times of crisis by providing a simplified framework for decision-making based on objective, evidence-based criteria, which is universally accepted and understood. When disaster strikes, the survival of the organisation depends on critical decision-making and quick actions to stabilise the incident. This paper argues that organisations need to supplement BIA processes with a decision-making triage methodology that can be quickly applied during the chaos of an actual event.

[LC-MS/MS analysis of determination of strychnine and brucine in formaldehyde fixed tissue].

PubMed

Zhan, Lan-fen; Liu, Ming-dong; Yan, You-yi; Ye, Yi; Wang, Wei; Wang, Zhi-hui; Zhao, Jun-hong; Liao, Lin-chuan

2012-10-01

To establish a method for determination of strychnine and brucine in formaldehyde fixed tissue by LC-MS/MS analysis. The samples were pretreated with solid phase extraction using SCX cartridges and separated on SB-C18 column with mobile phase 0.1% formic acid : 0.1% formic acid-acetonitrile (75:25). Electrospray ionization (ESI) source was utilized and operated in positive ion mode. Multiple reactions monitoring (MRM) mode was applied. External standard method was applied for quantitation. The chromatographic separation of strychnine and brucine in formaldehyde fixed nephritic and hepatic tissues resulted successfully. The standard curve was linear in the range of 0.002-2.0 microg/g for strychnine and brucine in formaldehyde fixed tissues, and the correlation coefficient was more than 0.996. The limits of detection (LOD) of strychnine and brucine in nephritic tissues were 0.06ng/g and 0.03 ng/g, respectively. The LOD of both chemicals were 0.3 ng/g in hepatic tissues. The extraction recovery rate was more than 74.5%. The precision of intra-day and inter-day were both less than 8.2%. Strychnine and brucine can be sensitive to be determined in formaldehyde fixed tissue by LC-MS/MS analysis. It can be applied in the forensic toxicological analysis.

Implementation of a novel taxonomy based on cognitive work analysis in the assessment of safety performance.

PubMed

Niskanen, Toivo

2017-12-12

The aim of this study was to examine how the developed taxonomy of cognitive work analysis (CWA) can be applied in combination with statistical analysis regarding different sociotechnical categories. This study applied a combination of quantitative and qualitative methodologies. Workers (n = 120) and managers (n = 85) in the chemical industry were asked in a questionnaire how different occupational safety and health (OSH) measures were being implemented. The exploration of the qualitative CWA taxonomy consisted of an analysis of the following topics: (a) work domain; (b) control task; (c) strategies; (d) social organization and cooperation; (e) worker competencies. The following hypotheses were supported - activities of the management had positive impacts on the aggregated variables: near-accident investigation and instructions (H 1 ); OSH training (H 2 ); operations, technical processes and safe use of chemicals (H 3 ); use of personal protective equipment (H 4 ); measuring, follow-up and prevention of major accidents (H 5 ). The CWA taxonomy was applied in mixed methods when testing H 1 -H 5 . A special approach is to analyze the work demands of complex sociotechnical systems with the taxonomy of CWA. In problem-solving, the CWA taxonomy should seek to capitalize on the strengths and minimize the limitations of safety performance.

Development of an Uncertainty Quantification Predictive Chemical Reaction Model for Syngas Combustion

DOE PAGES

Slavinskaya, N. A.; Abbasi, M.; Starcke, J. H.; ...

2017-01-24

An automated data-centric infrastructure, Process Informatics Model (PrIMe), was applied to validation and optimization of a syngas combustion model. The Bound-to-Bound Data Collaboration (B2BDC) module of PrIMe was employed to discover the limits of parameter modifications based on uncertainty quantification (UQ) and consistency analysis of the model–data system and experimental data, including shock-tube ignition delay times and laminar flame speeds. Existing syngas reaction models are reviewed, and the selected kinetic data are described in detail. Empirical rules were developed and applied to evaluate the uncertainty bounds of the literature experimental data. Here, the initial H 2/CO reaction model, assembled frommore » 73 reactions and 17 species, was subjected to a B2BDC analysis. For this purpose, a dataset was constructed that included a total of 167 experimental targets and 55 active model parameters. Consistency analysis of the composed dataset revealed disagreement between models and data. Further analysis suggested that removing 45 experimental targets, 8 of which were self-inconsistent, would lead to a consistent dataset. This dataset was subjected to a correlation analysis, which highlights possible directions for parameter modification and model improvement. Additionally, several methods of parameter optimization were applied, some of them unique to the B2BDC framework. The optimized models demonstrated improved agreement with experiments compared to the initially assembled model, and their predictions for experiments not included in the initial dataset (i.e., a blind prediction) were investigated. The results demonstrate benefits of applying the B2BDC methodology for developing predictive kinetic models.« less

Development of an Uncertainty Quantification Predictive Chemical Reaction Model for Syngas Combustion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Slavinskaya, N. A.; Abbasi, M.; Starcke, J. H.

An automated data-centric infrastructure, Process Informatics Model (PrIMe), was applied to validation and optimization of a syngas combustion model. The Bound-to-Bound Data Collaboration (B2BDC) module of PrIMe was employed to discover the limits of parameter modifications based on uncertainty quantification (UQ) and consistency analysis of the model–data system and experimental data, including shock-tube ignition delay times and laminar flame speeds. Existing syngas reaction models are reviewed, and the selected kinetic data are described in detail. Empirical rules were developed and applied to evaluate the uncertainty bounds of the literature experimental data. Here, the initial H 2/CO reaction model, assembled frommore » 73 reactions and 17 species, was subjected to a B2BDC analysis. For this purpose, a dataset was constructed that included a total of 167 experimental targets and 55 active model parameters. Consistency analysis of the composed dataset revealed disagreement between models and data. Further analysis suggested that removing 45 experimental targets, 8 of which were self-inconsistent, would lead to a consistent dataset. This dataset was subjected to a correlation analysis, which highlights possible directions for parameter modification and model improvement. Additionally, several methods of parameter optimization were applied, some of them unique to the B2BDC framework. The optimized models demonstrated improved agreement with experiments compared to the initially assembled model, and their predictions for experiments not included in the initial dataset (i.e., a blind prediction) were investigated. The results demonstrate benefits of applying the B2BDC methodology for developing predictive kinetic models.« less

Freedom space for rivers: An economically viable river management concept in a changing climate

NASA Astrophysics Data System (ADS)

Buffin-Bélanger, Thomas; Biron, Pascale M.; Larocque, Marie; Demers, Sylvio; Olsen, Taylor; Choné, Guénolé; Ouellet, Marie-Audray; Cloutier, Claude-André; Desjarlais, Claude; Eyquem, Joanna

2015-12-01

The freedom space concept applies hydrogeomorphic principles to delineate zones that are either frequently flooded or actively eroding, or that include riparian wetlands. Freedom space limits mapped for three rivers in southern Quebec (Canada) were assessed to determine whether they would still be valid under a future climate using a sensitivity analysis approach with numerical models predicting mobility of meanders (RVRMeander) and flood stage (HEC-RAS). The freedom space limits were also used in a cost-benefit analysis over a 50-year period where costs consist of loss or limitations to the right of farming and construction in this zone, whereas benefits are avoided costs for existing or future bank stabilization structures and avoided costs of flooding in agricultural areas. The economic value of ecosystem services provided by riparian wetlands and increased buffer zones within the freedom space were also included in the analysis. Results show that freedom space limits would be robust in future climate, and show net present values ranging from CDN0.7 to 3.7 million for the three rivers, with ratios of benefits over costs ranging between 1.5:1 and 4.8:1. River management based on freedom space is thus beneficial for society over a 50-year period.

Information Gap Analysis: near real-time evaluation of disaster response

NASA Astrophysics Data System (ADS)

Girard, Trevor

2014-05-01

Disasters, such as major storm events or earthquakes, trigger an immediate response by the disaster management system of the nation in question. The quality of this response is a large factor in its ability to limit the impacts on the local population. Improving the quality of disaster response therefore reduces disaster impacts. Studying past disasters is a valuable exercise to understand what went wrong, identify measures which could have mitigated these issues, and make recommendations to improve future disaster planning and response. While such ex post evaluations can lead to improvements in the disaster management system, there are limitations. The main limitation that has influenced this research is that ex post evaluations do not have the ability to inform the disaster response being assessed for the obvious reason that they are carried out long after the response phase is over. The result is that lessons learned can only be applied to future disasters. In the field of humanitarian relief, this limitation has led to the development of real time evaluations. The key aspect of real time humanitarian evaluations is that they are completed while the operation is still underway. This results in findings being delivered at a time when they can still make a difference to the humanitarian response. Applying such an approach to the immediate disaster response phase requires an even shorter time-frame, as well as a shift in focus from international actors to the nation in question's government. As such, a pilot study was started and methodology developed, to analyze disaster response in near real-time. The analysis uses the information provided by the disaster management system within the first 0 - 5 days of the response. The data is collected from publicly available sources such as ReliefWeb and sorted under various categories which represent each aspect of disaster response. This process was carried out for 12 disasters. The quantity and timeliness of information produced under each category was then compared to establish best practices. Thus, the information produced by a disaster management system following a major disaster can be compared to these best practices within days of the disaster. The resulting "information gap analysis" can help identify areas of the response that may need to be improved and raise questions as to why critical information is lacking or delayed. This information gap analysis therefore complements ex post evaluations and can help lead to improvements in the immediate response and subsequently reduce disaster impacts on the population. The methodology has already been applied in the Center for Disaster Management and Risk Reduction Technology's (CEDIM) Forensic Disaster Analysis (FDA) activities following tropical cyclone Phailin in India, and the Bohol Earthquake and Typhoon Haiyan in the Philippines.

Statistical process control and verifying positional accuracy of a cobra motion couch using step-wedge quality assurance tool.

PubMed

Binny, Diana; Lancaster, Craig M; Trapp, Jamie V; Crowe, Scott B

2017-09-01

This study utilizes process control techniques to identify action limits for TomoTherapy couch positioning quality assurance tests. A test was introduced to monitor accuracy of the applied couch offset detection in the TomoTherapy Hi-Art treatment system using the TQA "Step-Wedge Helical" module and MVCT detector. Individual X-charts, process capability (cp), probability (P), and acceptability (cpk) indices were used to monitor a 4-year couch IEC offset data to detect systematic and random errors in the couch positional accuracy for different action levels. Process capability tests were also performed on the retrospective data to define tolerances based on user-specified levels. A second study was carried out whereby physical couch offsets were applied using the TQA module and the MVCT detector was used to detect the observed variations. Random and systematic variations were observed for the SPC-based upper and lower control limits, and investigations were carried out to maintain the ongoing stability of the process for a 4-year and a three-monthly period. Local trend analysis showed mean variations up to ±0.5 mm in the three-monthly analysis period for all IEC offset measurements. Variations were also observed in the detected versus applied offsets using the MVCT detector in the second study largely in the vertical direction, and actions were taken to remediate this error. Based on the results, it was recommended that imaging shifts in each coordinate direction be only applied after assessing the machine for applied versus detected test results using the step helical module. User-specified tolerance levels of at least ±2 mm were recommended for a test frequency of once every 3 months to improve couch positional accuracy. SPC enables detection of systematic variations prior to reaching machine tolerance levels. Couch encoding system recalibrations reduced variations to user-specified levels and a monitoring period of 3 months using SPC facilitated in detecting systematic and random variations. SPC analysis for couch positional accuracy enabled greater control in the identification of errors, thereby increasing confidence levels in daily treatment setups. © 2017 Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

Thin Interface Asymptotics for an Energy/Entropy Approach to Phase-Field Models with Unequal Conductivities

NASA Technical Reports Server (NTRS)

McFadden, G. B.; Wheeler, A. A.; Anderson, D. M.

1999-01-01

Karma and Rapped recently developed a new sharp interface asymptotic analysis of the phase-field equations that is especially appropriate for modeling dendritic growth at low undercoolings. Their approach relieves a stringent restriction on the interface thickness that applies in the conventional asymptotic analysis, and has the added advantage that interfacial kinetic effects can also be eliminated. However, their analysis focussed on the case of equal thermal conductivities in the solid and liquid phases; when applied to a standard phase-field model with unequal conductivities, anomalous terms arise in the limiting forms of the boundary conditions for the interfacial temperature that are not present in conventional sharp-interface solidification models, as discussed further by Almgren. In this paper we apply their asymptotic methodology to a generalized phase-field model which is derived using a thermodynamically consistent approach that is based on independent entropy and internal energy gradient functionals that include double wells in both the entropy and internal energy densities. The additional degrees of freedom associated with the generalized phased-field equations can be chosen to eliminate the anomalous terms that arise for unequal conductivities.

Two-phase electromembrane extraction followed by gas chromatography-mass spectrometry analysis.

PubMed

Davarani, Saied Saeed Hosseiny; Morteza-Najarian, Amin; Nojavan, Saeed; Pourahadi, Ahmad; Abbassi, Mojtaba Beigzadeh

2013-02-01

A two-phase electromembrane extraction (EME) was developed and directly coupled with gas chromatography mass spectrometry (GC-MS) analysis. The proposed method was successfully applied to the simultaneous determination of imipramine, desipramine, citalopram and sertraline. The model compounds were extracted from neutral aqueous sample solutions into the organic phase filled in the lumen of the hollow fiber. This method was accomplished with 1-heptanol as organic phase, by means of 60 V applied voltage and with the extraction time of 15 min. Experiments reported recoveries in the range of 69-87% from 1.2 mL neutral sample solution. The compounds were quantified by GC-MS instrument, with acceptable linearity ranging from 1 to 500 ng mL(-1) (R(2) in the range of 0.989 to 0.998), and repeatability (RSD) ranging between 7.5 and 11.5% (n = 5). The estimated detection limits (S/N ratio of 3:1) were less than 0.25 ng mL(-1). This novel approach based on two-phase EME brought advantages such as simplicity, low-costing, low detection limit and fast extraction with a total analysis time less than 25 min. These experimental findings were highly interesting and demonstrated the possibility of solving ionic species in the organic phase at the presence of electrical potential. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Higuchi Dimension of Digital Images

PubMed Central

Ahammer, Helmut

2011-01-01

There exist several methods for calculating the fractal dimension of objects represented as 2D digital images. For example, Box counting, Minkowski dilation or Fourier analysis can be employed. However, there appear to be some limitations. It is not possible to calculate only the fractal dimension of an irregular region of interest in an image or to perform the calculations in a particular direction along a line on an arbitrary angle through the image. The calculations must be made for the whole image. In this paper, a new method to overcome these limitations is proposed. 2D images are appropriately prepared in order to apply 1D signal analyses, originally developed to investigate nonlinear time series. The Higuchi dimension of these 1D signals is calculated using Higuchi's algorithm, and it is shown that both regions of interests and directional dependencies can be evaluated independently of the whole picture. A thorough validation of the proposed technique and a comparison of the new method to the Fourier dimension, a common two dimensional method for digital images, are given. The main result is that Higuchi's algorithm allows a direction dependent as well as direction independent analysis. Actual values for the fractal dimensions are reliable and an effective treatment of regions of interests is possible. Moreover, the proposed method is not restricted to Higuchi's algorithm, as any 1D method of analysis, can be applied. PMID:21931854

Uncovering the effective interval of resolution parameter across multiple community optimization measures

NASA Astrophysics Data System (ADS)

Li, Hui-Jia; Cheng, Qing; Mao, He-Jin; Wang, Huanian; Chen, Junhua

2017-03-01

The study of community structure is a primary focus of network analysis, which has attracted a large amount of attention. In this paper, we focus on two famous functions, i.e., the Hamiltonian function H and the modularity density measure D, and intend to uncover the effective thresholds of their corresponding resolution parameter γ without resolution limit problem. Two widely used example networks are employed, including the ring network of lumps as well as the ad hoc network. In these two networks, we use discrete convex analysis to study the interval of resolution parameter of H and D that will not cause the misidentification. By comparison, we find that in both examples, for Hamiltonian function H, the larger the value of resolution parameter γ, the less resolution limit the network suffers; while for modularity density D, the less resolution limit the network suffers when we decrease the value of γ. Our framework is mathematically strict and efficient and can be applied in a lot of scientific fields.

The parametric modified limited penetrable visibility graph for constructing complex networks from time series

NASA Astrophysics Data System (ADS)

Li, Xiuming; Sun, Mei; Gao, Cuixia; Han, Dun; Wang, Minggang

2018-02-01

This paper presents the parametric modified limited penetrable visibility graph (PMLPVG) algorithm for constructing complex networks from time series. We modify the penetrable visibility criterion of limited penetrable visibility graph (LPVG) in order to improve the rationality of the original penetrable visibility and preserve the dynamic characteristics of the time series. The addition of view angle provides a new approach to characterize the dynamic structure of the time series that is invisible in the previous algorithm. The reliability of the PMLPVG algorithm is verified by applying it to three types of artificial data as well as the actual data of natural gas prices in different regions. The empirical results indicate that PMLPVG algorithm can distinguish the different time series from each other. Meanwhile, the analysis results of natural gas prices data using PMLPVG are consistent with the detrended fluctuation analysis (DFA). The results imply that the PMLPVG algorithm may be a reasonable and significant tool for identifying various time series in different fields.

A comparative analysis of longitudinal computed tomography and histopathology for evaluating the potential of mesenchymal stem cells in mitigating radiation-induced pulmonary fibrosis.

PubMed

Perez, Jessica R; Lee, Sangkyu; Ybarra, Norma; Maria, Ola; Serban, Monica; Jeyaseelan, Krishinima; Wang, Li Ming; Seuntjens, Jan; Naqa, Issam El

2017-08-22

Radiation-induced pulmonary fibrosis (RIPF) is a debilitating side effect that occurs in up to 30% of thoracic irradiations in breast and lung cancer patients. RIPF remains a major limiting factor to dose escalation and an obstacle to applying more promising new treatments for cancer cure. Limited treatment options are available to mitigate RIPF once it occurs, but recently, mesenchymal stem cells (MSCs) and a drug treatment stimulating endogenous stem cells (GM-CSF) have been investigated for their potential in preventing this disease onset. In a pre-clinical rat model, we contrasted the application of longitudinal computed tomography (CT) imaging and classical histopathology to quantify RIPF and to evaluate the potential of MSCs in mitigating RIPF. Our results on histology demonstrate promises when MSCs are injected endotracheally (but not intravenously). While our CT analysis highlights the potential of GM-CSF treatment. Advantages and limitations of both analytical methods are contrasted in the context of RIPF.

Transport properties of triarylamine based dendrimers studied by space charge limited current transients

NASA Astrophysics Data System (ADS)

Szymanski, Marek Z.; Kulszewicz-Bajer, Irena; Faure-Vincent, Jérôme; Djurado, David

2012-08-01

We have studied hole transport in triarylamine based dendrimer using space-charge-limited current transient technique. A mobility of 8 × 10-6 cm2/(V s) and a characteristic detrapping time of about 100 ms have been obtained. We found that quasi-ohmic contact is formed with gold. The obtained mobility differs from the apparent one given by the analysis of stationary current-voltage characteristics because of a limited contact efficiency. The comparison between transients obtained from fresh and aged samples reveals no change in mobility with aging. The deterioration of electrical properties is exclusively caused by trap formation and accumulation of ionic conducting impurities. Finally, repeated transient measurements have been applied to analyze the dynamics of charge trapping process.

Refinement and evaluation of helicopter real-time self-adaptive active vibration controller algorithms

NASA Technical Reports Server (NTRS)

Davis, M. W.

1984-01-01

A Real-Time Self-Adaptive (RTSA) active vibration controller was used as the framework in developing a computer program for a generic controller that can be used to alleviate helicopter vibration. Based upon on-line identification of system parameters, the generic controller minimizes vibration in the fuselage by closed-loop implementation of higher harmonic control in the main rotor system. The new generic controller incorporates a set of improved algorithms that gives the capability to readily define many different configurations by selecting one of three different controller types (deterministic, cautious, and dual), one of two linear system models (local and global), and one or more of several methods of applying limits on control inputs (external and/or internal limits on higher harmonic pitch amplitude and rate). A helicopter rotor simulation analysis was used to evaluate the algorithms associated with the alternative controller types as applied to the four-bladed H-34 rotor mounted on the NASA Ames Rotor Test Apparatus (RTA) which represents the fuselage. After proper tuning all three controllers provide more effective vibration reduction and converge more quickly and smoothly with smaller control inputs than the initial RTSA controller (deterministic with external pitch-rate limiting). It is demonstrated that internal limiting of the control inputs a significantly improves the overall performance of the deterministic controller.

36 CFR § 1226.14 - What are the limitations in applying approved records schedules?

Code of Federal Regulations, 2013 CFR

2013-07-01

... applying approved records schedules? § 1226.14 Section § 1226.14 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT IMPLEMENTING DISPOSITION § 1226.14 What are the limitations in applying approved records schedules? Agencies must apply the approved records...

Application of Allan Deviation to Assessing Uncertainties of Continuous-measurement Instruments, and Optimizing Calibration Schemes

NASA Astrophysics Data System (ADS)

Jacobson, Gloria; Rella, Chris; Farinas, Alejandro

2014-05-01

Technological advancement of instrumentation in atmospheric and other geoscience disciplines over the past decade has lead to a shift from discrete sample analysis to continuous, in-situ monitoring. Standard error analysis used for discrete measurements is not sufficient to assess and compare the error contribution of noise and drift from continuous-measurement instruments, and a different statistical analysis approach should be applied. The Allan standard deviation analysis technique developed for atomic clock stability assessment by David W. Allan [1] can be effectively and gainfully applied to continuous measurement instruments. As an example, P. Werle et al has applied these techniques to look at signal averaging for atmospheric monitoring by Tunable Diode-Laser Absorption Spectroscopy (TDLAS) [2]. This presentation will build on, and translate prior foundational publications to provide contextual definitions and guidelines for the practical application of this analysis technique to continuous scientific measurements. The specific example of a Picarro G2401 Cavity Ringdown Spectroscopy (CRDS) analyzer used for continuous, atmospheric monitoring of CO2, CH4 and CO will be used to define the basics features the Allan deviation, assess factors affecting the analysis, and explore the time-series to Allan deviation plot translation for different types of instrument noise (white noise, linear drift, and interpolated data). In addition, the useful application of using an Allan deviation to optimize and predict the performance of different calibration schemes will be presented. Even though this presentation will use the specific example of the Picarro G2401 CRDS Analyzer for atmospheric monitoring, the objective is to present the information such that it can be successfully applied to other instrument sets and disciplines. [1] D.W. Allan, "Statistics of Atomic Frequency Standards," Proc, IEEE, vol. 54, pp 221-230, Feb 1966 [2] P. Werle, R. Miicke, F. Slemr, "The Limits of Signal Averaging in Atmospheric Trace-Gas Monitoring by Tunable Diode-Laser Absorption Spectroscopy (TDLAS)," Applied Physics, B57, pp 131-139, April 1993

Different spectrophotometric methods applied for the analysis of simeprevir in the presence of its oxidative degradation product: Acomparative study

NASA Astrophysics Data System (ADS)

Attia, Khalid A. M.; El-Abasawi, Nasr M.; El-Olemy, Ahmed; Serag, Ahmed

2018-02-01

Five simple spectrophotometric methods were developed for the determination of simeprevir in the presence of its oxidative degradation product namely, ratio difference, mean centering, derivative ratio using the Savitsky-Golay filters, second derivative and continuous wavelet transform. These methods are linear in the range of 2.5-40 μg/mL and validated according to the ICH guidelines. The obtained results of accuracy, repeatability and precision were found to be within the acceptable limits. The specificity of the proposed methods was tested using laboratory prepared mixtures and assessed by applying the standard addition technique. Furthermore, these methods were statistically comparable to RP-HPLC method and good results were obtained. So, they can be used for the routine analysis of simeprevir in quality-control laboratories.

25 CFR 243.5 - Who can own imported reindeer, and what limitations apply?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Who can own imported reindeer, and what limitations apply? 243.5 Section 243.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.5 Who can own imported reindeer, and what limitations apply? (a) Anyone, including non-Natives, may own imported reindeer i...

A data-drive analysis for heavy quark diffusion coefficient

NASA Astrophysics Data System (ADS)

Xu, Yingru; Nahrgang, Marlene; Cao, Shanshan; Bernhard, Jonah E.; Bass, Steffen A.

2018-02-01

We apply a Bayesian model-to-data analysis on an improved Langevin framework to estimate the temperature and momentum dependence of the heavy quark diffusion coefficient in the quark-gluon plasma (QGP). The spatial diffusion coefficient is found to have a minimum around 1-3 near Tc in the zero momentum limit, and has a non-trivial momentum dependence. With the estimated diffusion coefficient, our improved Langevin model is able to simultaneously describe the D-meson RAA and v2 in three different systems at RHIC and the LHC.

The use of experimental design for the development of a capillary zone electrophoresis method for the quantitation of captopril.

PubMed

Mukozhiwa, S Y; Khamanga, S M M; Walker, R B

2017-09-01

A capillary zone electrophoresis (CZE) method for the quantitation of captopril (CPT) using UV detection was developed. Influence of electrolyte concentration and system variables on electrophoretic separation was evaluated and a central composite design (CCD) was used to optimize the method. Variables investigated were pH, molarity, applied voltage and capillary length. The influence of sodium metabisulphite on the stability of test solutions was also investigated. The use of sodium metabisulphite prevented degradation of CPT over 24 hours. A fused uncoated silica capillary of 67.5cm total and 57.5 cm effective length was used for analysis. The applied voltage and capillary length affected the migration time of CPT significantly. A 20 mM phosphate buffer adjusted to pH 7.0 was used as running buffer and an applied voltage of 23.90 kV was suitable to effect a separation. The optimized electrophoretic conditions produced sharp, well-resolved peaks for CPT and sodium metabisulphite. Linear regression analysis of the response for CPT standards revealed the method was linear (R2 = 0.9995) over the range 5-70 μg/mL. The limits of quantitation and detection were 5 and 1.5 μg/mL. A simple, rapid and reliable CZE method has been developed and successfully applied to the analysis of commercially available CPT products.

Improvement of direct determination of trace nickel in environmental samples by diffuse reflection spectroscopy using chromaticity characteristics.

PubMed

Ershova, N I; Ivanov, V M

2000-05-01

Cellulose and chromaton-N-super as solid supports for direct determination of the immobilized nickel complexes with dimethylglyoxime and benzyldioxime by diffuse reflection spectroscopy were compared. The advantage of chromaton-N-super with use of benzyldioxime is shown. Detection limit is 0.02 microg/mL. The proposed method was applied for the analysis of soil.

An Evaluation of the Precision of Measurement of Ryff's Psychological Well-Being Scales in a Population Sample

ERIC Educational Resources Information Center

Abbott, Rosemary A.; Ploubidis, George B.; Huppert, Felicia A.; Kuh, Diana; Croudace, Tim J.

2010-01-01

The aim of this study is to assess the effective measurement range of Ryff's Psychological Well-being scales (PWB). It applies normal ogive item response theory (IRT) methodology using factor analysis procedures for ordinal data based on a limited information estimation approach. The data come from a sample of 1,179 women participating in a…

On the (In)Validity of Tests of Simple Mediation: Threats and Solutions

PubMed Central

Pek, Jolynn; Hoyle, Rick H.

2015-01-01

Mediation analysis is a popular framework for identifying underlying mechanisms in social psychology. In the context of simple mediation, we review and discuss the implications of three facets of mediation analysis: (a) conceptualization of the relations between the variables, (b) statistical approaches, and (c) relevant elements of design. We also highlight the issue of equivalent models that are inherent in simple mediation. The extent to which results are meaningful stem directly from choices regarding these three facets of mediation analysis. We conclude by discussing how mediation analysis can be better applied to examine causal processes, highlight the limits of simple mediation, and make recommendations for better practice. PMID:26985234

Validation of the replica trick for simple models

NASA Astrophysics Data System (ADS)

Shinzato, Takashi

2018-04-01

We discuss the replica analytic continuation using several simple models in order to prove mathematically the validity of the replica analysis, which is used in a wide range of fields related to large-scale complex systems. While replica analysis consists of two analytical techniques—the replica trick (or replica analytic continuation) and the thermodynamical limit (and/or order parameter expansion)—we focus our study on replica analytic continuation, which is the mathematical basis of the replica trick. We apply replica analysis to solve a variety of analytical models, and examine the properties of replica analytic continuation. Based on the positive results for these models we propose that replica analytic continuation is a robust procedure in replica analysis.

Mentorship and competencies for applied chronic disease epidemiology.

PubMed

Lengerich, Eugene J; Siedlecki, Jennifer C; Brownson, Ross; Aldrich, Tim E; Hedberg, Katrina; Remington, Patrick; Siegel, Paul Z

2003-01-01

To understand the potential and establish a framework for mentoring as a method to develop professional competencies of state-level applied chronic disease epidemiologists, model mentorship programs were reviewed, specific competencies were identified, and competencies were then matched to essential public health services. Although few existing mentorship programs in public health were identified, common themes in other professional mentorship programs support the potential of mentoring as an effective means to develop capacity for applied chronic disease epidemiology. Proposed competencies for chronic disease epidemiologists in a mentorship program include planning, analysis, communication, basic public health, informatics and computer knowledge, and cultural diversity. Mentoring may constitute a viable strategy to build chronic disease epidemiology capacity, especially in public health agencies where resource and personnel system constraints limit opportunities to recruit and hire new staff.

76 FR 20789 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

... date on which a limit up/limit down mechanism to address extraordinary market volatility, if adopted... down mechanism to address extraordinary market volatility, if adopted, applies [April 11, 2011]. If the... which a limit up/limit down mechanism to address extraordinary market volatility, if adopted, applies...

Detection of hazardous pollutants in chrome-tanned leather using locally developed laser-induced breakdown spectrometer.

PubMed

Nasr, M M; Gondal, Mohammed Asharf; Seddigi, Z S

2011-04-01

Highly toxic contaminants like Cr, As, and Pb were detected in chrome-tanning process of animal skin to produce leather by applying locally developed laser-induced breakdown spectrometer. An Nd-YAG laser with 1,064 nm wavelength was focused on the surface of leather samples (natural and manufactured) to generate a plasma spark and spectrally resolved spectra were used for identification and quantification of contaminants. The leather samples were collected from a tannery located in industrial cities of Riyadh and Jeddah, Saudi Arabia. The study was carried out on fully, half manufactured (wet blue leather), and natural hide (skin). To the best of our knowledge, this is the first attempt where laser-induced breakdown spectroscopy (LIBS) technique has been applied for the analysis of leather before and after tanning process. The maximum concentration of different elements of environmental significance like chromium, lead, arsenic, sulfur, magnesium were 199, 289, 31, 38, and 39 ppm, respectively, in one of the manufactured leather samples. The limit of detection (LOD) of our LIBS system for chromium, lead, arsenic, sulfur, and magnesium were 2, 3, 1.5,7, and 3 ppm, respectively. The safe permissible limit for tanned leather for highly toxic elements like chromium, lead, and arsenic are 1, 0.5, 0.01 ppm, respectively, as prescribed in Environmental Regulation Standards for Saudi Industries set by Royal Commission Jubail, Saudi Arabia. The LIBS technique is superior to other conventional techniques like ICP or atomic absorption that a little or no sample preparation is required, no chemicals are needed, multi-elemental analysis is possible for all kinds of samples (natural and anthropogenic materials), microgram of sample is essential, and LIBS could be applied for remote analysis. It is highly selective and sensitivity higher than ICP, and as no sample and chemicals are required, it is cost effective for multi-sample analysis per unit time as compared with other conventional techniques. The concentration of some toxic elements (Cr, Pb, As) is much higher than the safe permissible limits set by Occupational Safety and Health Administration in USA or Saudi environmental regulatory agencies. Results obtained with our LIBS systems were in close agreement with the results obtained using other standard analytical technique such as the inductively coupled plasma atomic emission spectroscopy.

Simultaneous determination of benznidazole and itraconazole using spectrophotometry applied to the analysis of mixture: A tool for quality control in the development of formulations

NASA Astrophysics Data System (ADS)

Pinho, Ludmila A. G.; Sá-Barreto, Lívia C. L.; Infante, Carlos M. C.; Cunha-Filho, Marcílio S. S.

2016-04-01

The aim of this work was the development of an analytical procedure using spectrophotometry for simultaneous determination of benznidazole (BNZ) and itraconazole (ITZ) in a medicine used for the treatment of Chagas disease. In order to achieve this goal, the analysis of mixtures was performed applying the Lambert-Beer law through the absorbances of BNZ and ITZ in the wavelengths 259 and 321 nm, respectively. Diverse tests were carried out for development and validation of the method, which proved to be selective, robust, linear, and precise. The lower limits of detection and quantification demonstrate its sensitivity to quantify small amounts of analytes, enabling its application for various analytical purposes, such as dissolution test and routine assays. In short, the quantification of BNZ and ITZ by analysis of mixtures had shown to be efficient and cost-effective alternative for determination of these drugs in a pharmaceutical dosage form.

[Preparation of a novel activated carbon coating fiber for solid phase micro-extraction and its application for halocarbon compound analysis in water].

PubMed

Wang, Shutao; Wang, Yan; You, Hong; Liang, Zhihua

2004-09-01

A novel activated carbon coating fiber used for solid phase micro-extraction (SPME) was prepared using activated carbon powder and silica resin adhesive. The extraction properties of the novel activated carbon coating fiber were investigated. The results indicate that this coating fiber has high concentration ability, with enrichment factors for chloroform, carbon tetrachloride, trichloroethylene and tetrachloroethylene in the range of 13.8 to 18.7. The fiber is stable at temperature as high as 290 degrees C and it can be used for over 140 times at 250 degrees C. The activated carbon coating fiber was then applied to the analysis of the four halocarbon compounds mentioned above. A linear correlation with correlation coefficients between 0.995 2 and 0.999 4 and the detection limits between 0.008 and 0.05 microg/L were observed. The method was also applied to a real water sample analysis and the recoveries of these halocarbon compounds were from 95.5% to 104.6%.

Simultaneous determination of benznidazole and itraconazole using spectrophotometry applied to the analysis of mixture: A tool for quality control in the development of formulations.

PubMed

Pinho, Ludmila A G; Sá-Barreto, Lívia C L; Infante, Carlos M C; Cunha-Filho, Marcílio S S

2016-04-15

The aim of this work was the development of an analytical procedure using spectrophotometry for simultaneous determination of benznidazole (BNZ) and itraconazole (ITZ) in a medicine used for the treatment of Chagas disease. In order to achieve this goal, the analysis of mixtures was performed applying the Lambert-Beer law through the absorbances of BNZ and ITZ in the wavelengths 259 and 321 nm, respectively. Diverse tests were carried out for development and validation of the method, which proved to be selective, robust, linear, and precise. The lower limits of detection and quantification demonstrate its sensitivity to quantify small amounts of analytes, enabling its application for various analytical purposes, such as dissolution test and routine assays. In short, the quantification of BNZ and ITZ by analysis of mixtures had shown to be efficient and cost-effective alternative for determination of these drugs in a pharmaceutical dosage form. Copyright © 2016. Published by Elsevier B.V.

Single-cell topological RNA-Seq analysis reveals insights into cellular differentiation and development

PubMed Central

Rizvi, Abbas H.; Camara, Pablo G.; Kandror, Elena K.; Roberts, Thomas J.; Schieren, Ira; Maniatis, Tom; Rabadan, Raul

2017-01-01

Transcriptional programs control cellular lineage commitment and differentiation during development. Understanding cell fate has been advanced by studying single-cell RNA-seq, but is limited by the assumptions of current analytic methods regarding the structure of data. We present single-cell topological data analysis (scTDA), an algorithm for topology-based computational analyses to study temporal, unbiased transcriptional regulation. Compared to other methods, scTDA is a non-linear, model-independent, unsupervised statistical framework that can characterize transient cellular states. We applied scTDA to the analysis of murine embryonic stem cell (mESC) differentiation in vitro in response to inducers of motor neuron differentiation. scTDA resolved asynchrony and continuity in cellular identity over time, and identified four transient states (pluripotent, precursor, progenitor, and fully differentiated cells) based on changes in stage-dependent combinations of transcription factors, RNA-binding proteins and long non-coding RNAs. scTDA can be applied to study asynchronous cellular responses to either developmental cues or environmental perturbations. PMID:28459448

40 CFR 430.15 - New source performance standards (NSPS).

Code of Federal Regulations, 2011 CFR

2011-07-01

..., concentration limitations (mg/l) shall apply, where provided. Concentration limitations will only apply to non-continuous dischargers. Only facilities where chlorophenolic-containing biocides are used shall be subject to pentachlorophenol and trichlorophenol limitations. Permittees not using chlorophenolic-containing biocides must...

Analysis of biomolecular solvation sites by 3D-RISM theory.

PubMed

Sindhikara, Daniel J; Hirata, Fumio

2013-06-06

We derive, implement, and apply equilibrium solvation site analysis for biomolecules. Our method utilizes 3D-RISM calculations to quickly obtain equilibrium solvent distributions without either necessity of simulation or limits of solvent sampling. Our analysis of these distributions extracts highest likelihood poses of solvent as well as localized entropies, enthalpies, and solvation free energies. We demonstrate our method on a structure of HIV-1 protease where excellent structural and thermodynamic data are available for comparison. Our results, obtained within minutes, show systematic agreement with available experimental data. Further, our results are in good agreement with established simulation-based solvent analysis methods. This method can be used not only for visual analysis of active site solvation but also for virtual screening methods and experimental refinement.

Probabilistic Sensitivity Analysis for Launch Vehicles with Varying Payloads and Adapters for Structural Dynamics and Loads

NASA Technical Reports Server (NTRS)

McGhee, David S.; Peck, Jeff A.; McDonald, Emmett J.

2012-01-01

This paper examines Probabilistic Sensitivity Analysis (PSA) methods and tools in an effort to understand their utility in vehicle loads and dynamic analysis. Specifically, this study addresses how these methods may be used to establish limits on payload mass and cg location and requirements on adaptor stiffnesses while maintaining vehicle loads and frequencies within established bounds. To this end, PSA methods and tools are applied to a realistic, but manageable, integrated launch vehicle analysis where payload and payload adaptor parameters are modeled as random variables. This analysis is used to study both Regional Response PSA (RRPSA) and Global Response PSA (GRPSA) methods, with a primary focus on sampling based techniques. For contrast, some MPP based approaches are also examined.

40 CFR Table 8 to Subpart Dddd of... - Model Rule-Emission Limitations That Apply to Waste-Burning Kilns After May 20, 2011

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 7 2013-07-01 2013-07-01 false Model Rule-Emission Limitations That Apply to Waste-Burning Kilns After May 20, 2011 8 Table 8 to Subpart DDDD of Part 60 Protection of...—Emission Limitations That Apply to Waste-Burning Kilns After May 20, 2011 [Date to be specified in state...

40 CFR Table 8 to Subpart Dddd of... - Model Rule-Emission Limitations That Apply to Waste-Burning Kilns After May 20, 2011

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 7 2014-07-01 2014-07-01 false Model Rule-Emission Limitations That Apply to Waste-Burning Kilns After May 20, 2011 8 Table 8 to Subpart DDDD of Part 60 Protection of...—Emission Limitations That Apply to Waste-Burning Kilns After May 20, 2011 [Date to be specified in state...

40 CFR Table 8 to Subpart Dddd of... - Model Rule-Emission Limitations That Apply to Waste-Burning Kilns After May 20, 2011

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 7 2012-07-01 2012-07-01 false Model Rule-Emission Limitations That Apply to Waste-Burning Kilns After May 20, 2011 8 Table 8 to Subpart DDDD of Part 60 Protection of...—Emission Limitations That Apply to Waste-Burning Kilns After May 20, 2011 For the air pollutant You must...

13 CFR 123.105 - How much can I borrow with a home disaster loan and what limits apply on use of funds and...

Code of Federal Regulations, 2012 CFR

2012-01-01

... disaster loan and what limits apply on use of funds and repayment terms? 123.105 Section 123.105 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Home Disaster Loans § 123.105 How much can I borrow with a home disaster loan and what limits apply on use of funds and repayment...

13 CFR 123.105 - How much can I borrow with a home disaster loan and what limits apply on use of funds and...

Code of Federal Regulations, 2014 CFR

2014-01-01

... disaster loan and what limits apply on use of funds and repayment terms? 123.105 Section 123.105 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Home Disaster Loans § 123.105 How much can I borrow with a home disaster loan and what limits apply on use of funds and repayment...

13 CFR 123.105 - How much can I borrow with a home disaster loan and what limits apply on use of funds and...

Code of Federal Regulations, 2010 CFR

2010-01-01

... disaster loan and what limits apply on use of funds and repayment terms? 123.105 Section 123.105 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Home Disaster Loans § 123.105 How much can I borrow with a home disaster loan and what limits apply on use of funds and repayment...

13 CFR 123.105 - How much can I borrow with a home disaster loan and what limits apply on use of funds and...

Code of Federal Regulations, 2013 CFR

2013-01-01

... disaster loan and what limits apply on use of funds and repayment terms? 123.105 Section 123.105 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Home Disaster Loans § 123.105 How much can I borrow with a home disaster loan and what limits apply on use of funds and repayment...

13 CFR 123.105 - How much can I borrow with a home disaster loan and what limits apply on use of funds and...

Code of Federal Regulations, 2011 CFR

2011-01-01

... disaster loan and what limits apply on use of funds and repayment terms? 123.105 Section 123.105 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Home Disaster Loans § 123.105 How much can I borrow with a home disaster loan and what limits apply on use of funds and repayment...

Zero-Bounded Limits as a Special Case of the Squeeze Theorem for Evaluating Single-Variable and Multivariable Limits

ERIC Educational Resources Information Center

Gkioulekas, Eleftherios

2013-01-01

Many limits, typically taught as examples of applying the "squeeze" theorem, can be evaluated more easily using the proposed zero-bounded limit theorem. The theorem applies to functions defined as a product of a factor going to zero and a factor that remains bounded in some neighborhood of the limit. This technique is immensely useful…

Linked Sensitivity Analysis, Calibration, and Uncertainty Analysis Using a System Dynamics Model for Stroke Comparative Effectiveness Research.

PubMed

Tian, Yuan; Hassmiller Lich, Kristen; Osgood, Nathaniel D; Eom, Kirsten; Matchar, David B

2016-11-01

As health services researchers and decision makers tackle more difficult problems using simulation models, the number of parameters and the corresponding degree of uncertainty have increased. This often results in reduced confidence in such complex models to guide decision making. To demonstrate a systematic approach of linked sensitivity analysis, calibration, and uncertainty analysis to improve confidence in complex models. Four techniques were integrated and applied to a System Dynamics stroke model of US veterans, which was developed to inform systemwide intervention and research planning: Morris method (sensitivity analysis), multistart Powell hill-climbing algorithm and generalized likelihood uncertainty estimation (calibration), and Monte Carlo simulation (uncertainty analysis). Of 60 uncertain parameters, sensitivity analysis identified 29 needing calibration, 7 that did not need calibration but significantly influenced key stroke outcomes, and 24 not influential to calibration or stroke outcomes that were fixed at their best guess values. One thousand alternative well-calibrated baselines were obtained to reflect calibration uncertainty and brought into uncertainty analysis. The initial stroke incidence rate among veterans was identified as the most influential uncertain parameter, for which further data should be collected. That said, accounting for current uncertainty, the analysis of 15 distinct prevention and treatment interventions provided a robust conclusion that hypertension control for all veterans would yield the largest gain in quality-adjusted life years. For complex health care models, a mixed approach was applied to examine the uncertainty surrounding key stroke outcomes and the robustness of conclusions. We demonstrate that this rigorous approach can be practical and advocate for such analysis to promote understanding of the limits of certainty in applying models to current decisions and to guide future data collection. © The Author(s) 2016.

Tools for Large-Scale Mobile Malware Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bierma, Michael

Analyzing mobile applications for malicious behavior is an important area of re- search, and is made di cult, in part, by the increasingly large number of appli- cations available for the major operating systems. There are currently over 1.2 million apps available in both the Google Play and Apple App stores (the respec- tive o cial marketplaces for the Android and iOS operating systems)[1, 2]. Our research provides two large-scale analysis tools to aid in the detection and analysis of mobile malware. The rst tool we present, Andlantis, is a scalable dynamic analysis system capa- ble of processing over 3000more » Android applications per hour. Traditionally, Android dynamic analysis techniques have been relatively limited in scale due to the compu- tational resources required to emulate the full Android system to achieve accurate execution. Andlantis is the most scalable Android dynamic analysis framework to date, and is able to collect valuable forensic data, which helps reverse-engineers and malware researchers identify and understand anomalous application behavior. We discuss the results of running 1261 malware samples through the system, and provide examples of malware analysis performed with the resulting data. While techniques exist to perform static analysis on a large number of appli- cations, large-scale analysis of iOS applications has been relatively small scale due to the closed nature of the iOS ecosystem, and the di culty of acquiring appli- cations for analysis. The second tool we present, iClone, addresses the challenges associated with iOS research in order to detect application clones within a dataset of over 20,000 iOS applications.« less

Neutron tomographic analysis: Material characterization of silver and electrum coins from the 6th and 5th centuries BCE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Salvemini, F., E-mail: filomena.salvemini@ansto.go

Neutron tomography was applied to study a set of Greek silver coins and a single Lydian electrum coin minted in the 6 and 5th centuries BCE. The investigation was conducted at the new neutron imaging station DINGO at ANSTO in order to demonstrate capabilities and to explore limits of this non-invasive method in characterizing numismatic materials. From the reconstructed volume of each sample, the morphology, porosity, inclusions, and presence of composite structures can be revealed and evaluated. This information can be used to elucidate ancient minting technology and to prove authenticity. Moreover, the state of conservation, corrosion processes and attemptsmore » to repair the coins can be determined. - Highlights: •Pre-Roman coins •Non-destructive analysis •Neutron tomography: limit and capability.« less

Monitoring of biogenic amines and drugs of various therapeutic groups in urine samples with use of HPLC.

PubMed

Baranowska, Irena; Płonka, Joanna

2016-04-01

A high-performance liquid chromatography method for simultaneous separation and determination of biogenic amines [dopamine, epinephrine, serotonin and its six metabolites (normetanephrine, metanephrine, 3,4-dihydroxyphenylacetic acid, 4-hydroxy-3-methoxyphenylglycol, homovanilic acid and 5-hydroxyindoloacetic acid)] with drugs from different therapeutically groups [analgesics (paracetamol, metamizol), diuretics (furosemide) and antibiotics (cefazolin, fluconazole)] was developed. A chromatographic column with pre-column with octadecylsilane phase (C18e ) and two detectors - diode array serial connected and fluorescence - was used. Gradient elution of mixture of acetate buffer (pH 4.66) and methanol as a mobile phase was applied. The limit of detection (LOD) of 8-10 ng/mL and limit of quantitation (LOQ) of 24-30 ng/mL for biogenic amines, as well as the LOD of 50-100 ng/mL and the LOQ of 150-300 ng/mL for drugs, were determined. The applied sample preparation method allowed recoveries of 93% for the biogenic amines and 92% for the drugs to be achieved. The developed procedure has been applied to simultaneous determination of the examined compounds in urine samples and could be used in clinical analysis. Copyright © 2015 John Wiley & Sons, Ltd.

Principal shapes and squeezed limits in the effective field theory of large scale structure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bertolini, Daniele; Solon, Mikhail P., E-mail: dbertolini@lbl.gov, E-mail: mpsolon@lbl.gov

2016-11-01

We apply an orthogonalization procedure on the effective field theory of large scale structure (EFT of LSS) shapes, relevant for the angle-averaged bispectrum and non-Gaussian covariance of the matter power spectrum at one loop. Assuming natural-sized EFT parameters, this identifies a linear combination of EFT shapes—referred to as the principal shape—that gives the dominant contribution for the whole kinematic plane, with subdominant combinations suppressed by a few orders of magnitude. For the covariance, our orthogonal transformation is in excellent agreement with a principal component analysis applied to available data. Additionally we find that, for both observables, the coefficients of themore » principal shapes are well approximated by the EFT coefficients appearing in the squeezed limit, and are thus measurable from power spectrum response functions. Employing data from N-body simulations for the growth-only response, we measure the single EFT coefficient describing the angle-averaged bispectrum with Ο (10%) precision. These methods of shape orthogonalization and measurement of coefficients from response functions are valuable tools for developing the EFT of LSS framework, and can be applied to more general observables.« less

A renaissance in residential behavior analysis? A historical perspective and a better way to help people with challenging behavior

PubMed Central

Holburn, Steve

1997-01-01

After a slow start, the popularity of applied behavior analysis for people with severe behavior problems peaked in the 1970s and was then battered down by the effects of methodological behaviorism, the aversives controversy, overregulation, and the inherent limitations of congregate living. Despite the ethical, technical, and conceptual advancements in behavior analysis, many people with challenging behavior live in futile environments in which the behavior analyst can only tinker. A radically behavioristic approach has become available that has the power to change these conditions, to restore the reciprocity necessary for new learning, and to bring residential behavior analysts more in contact with the contingencies of helping and teaching. The approach is consistent with alternatives that behaviorists have suggested for years to improve the image and effectiveness of applied behavior analysis, although it will take the behaviorist far from the usual patterns of practice. Finally, the approach promotes its own survival by promoting access to interlocking organizational contingencies, but its antithetical nature presents many conceptual and practical challenges to agency adoption. PMID:22478282

Multivariate data analysis on historical IPV production data for better process understanding and future improvements.

PubMed

Thomassen, Yvonne E; van Sprang, Eric N M; van der Pol, Leo A; Bakker, Wilfried A M

2010-09-01

Historical manufacturing data can potentially harbor a wealth of information for process optimization and enhancement of efficiency and robustness. To extract useful data multivariate data analysis (MVDA) using projection methods is often applied. In this contribution, the results obtained from applying MVDA on data from inactivated polio vaccine (IPV) production runs are described. Data from over 50 batches at two different production scales (700-L and 1,500-L) were available. The explorative analysis performed on single unit operations indicated consistent manufacturing. Known outliers (e.g., rejected batches) were identified using principal component analysis (PCA). The source of operational variation was pinpointed to variation of input such as media. Other relevant process parameters were in control and, using this manufacturing data, could not be correlated to product quality attributes. The gained knowledge of the IPV production process, not only from the MVDA, but also from digitalizing the available historical data, has proven to be useful for troubleshooting, understanding limitations of available data and seeing the opportunity for improvements. 2010 Wiley Periodicals, Inc.

[New method of mixed gas infrared spectrum analysis based on SVM].

PubMed

Bai, Peng; Xie, Wen-Jun; Liu, Jun-Hua

2007-07-01

A new method of infrared spectrum analysis based on support vector machine (SVM) for mixture gas was proposed. The kernel function in SVM was used to map the seriously overlapping absorption spectrum into high-dimensional space, and after transformation, the high-dimensional data could be processed in the original space, so the regression calibration model was established, then the regression calibration model with was applied to analyze the concentration of component gas. Meanwhile it was proved that the regression calibration model with SVM also could be used for component recognition of mixture gas. The method was applied to the analysis of different data samples. Some factors such as scan interval, range of the wavelength, kernel function and penalty coefficient C that affect the model were discussed. Experimental results show that the component concentration maximal Mean AE is 0.132%, and the component recognition accuracy is higher than 94%. The problems of overlapping absorption spectrum, using the same method for qualitative and quantitative analysis, and limit number of training sample, were solved. The method could be used in other mixture gas infrared spectrum analyses, promising theoretic and application values.

Linear and nonlinear analysis of kinetic Alfven waves in quantum magneto-plasmas with arbitrary temperature degeneracy

NASA Astrophysics Data System (ADS)

Sadiq, Nauman; Ahmad, Mushtaq; Farooq, M.; Jan, Qasim

2018-06-01

Linear and nonlinear kinetic Alfven waves (KAWs) are studied in collisionless, non-relativistic two fluid quantum magneto-plasmas by considering arbitrary temperature degeneracy. A general coupling parameter is applied to discuss the range of validity of the proposed model in nearly degenerate and nearly non-degenerate plasma limits. Linear analysis of KAWs shows an increase (decrease) in frequency with the increase in parameter ζ ( δ ) for the nearly non-degenerate (nearly degenerate) plasma limit. The energy integral equation in the form of Sagdeev potential is obtained by using the approach of the Lorentz transformation. The analysis reveals that the amplitude of the Sagdeev potential curves and soliton structures remains the same, but the potential depth and width of soliton structure change for both the limiting cases. It is further observed that only density hump structures are formed in the sub-alfvenic region for value Kz 2 > 1 . The effects of parameters ζ, δ on the nonlinear properties of KAWs are shown in graphical plots. New results for comparison with earlier work have also been highlighted. The significance of this work to astrophysical plasmas is also emphasized.

Social network models predict movement and connectivity in ecological landscapes

USGS Publications Warehouse

Fletcher, R.J.; Acevedo, M.A.; Reichert, Brian E.; Pias, Kyle E.; Kitchens, W.M.

2011-01-01

Network analysis is on the rise across scientific disciplines because of its ability to reveal complex, and often emergent, patterns and dynamics. Nonetheless, a growing concern in network analysis is the use of limited data for constructing networks. This concern is strikingly relevant to ecology and conservation biology, where network analysis is used to infer connectivity across landscapes. In this context, movement among patches is the crucial parameter for interpreting connectivity but because of the difficulty of collecting reliable movement data, most network analysis proceeds with only indirect information on movement across landscapes rather than using observed movement to construct networks. Statistical models developed for social networks provide promising alternatives for landscape network construction because they can leverage limited movement information to predict linkages. Using two mark-recapture datasets on individual movement and connectivity across landscapes, we test whether commonly used network constructions for interpreting connectivity can predict actual linkages and network structure, and we contrast these approaches to social network models. We find that currently applied network constructions for assessing connectivity consistently, and substantially, overpredict actual connectivity, resulting in considerable overestimation of metapopulation lifetime. Furthermore, social network models provide accurate predictions of network structure, and can do so with remarkably limited data on movement. Social network models offer a flexible and powerful way for not only understanding the factors influencing connectivity but also for providing more reliable estimates of connectivity and metapopulation persistence in the face of limited data.

Capillary ion chromatography with on-column focusing for ultra-trace analysis of methanesulfonate and inorganic anions in limited volume Antarctic ice core samples.

PubMed

Rodriguez, Estrella Sanz; Poynter, Sam; Curran, Mark; Haddad, Paul R; Shellie, Robert A; Nesterenko, Pavel N; Paull, Brett

2015-08-28

Preservation of ionic species within Antarctic ice yields a unique proxy record of the Earth's climate history. Studies have been focused until now on two proxies: the ionic components of sea salt aerosol and methanesulfonic acid. Measurement of the all of the major ionic species in ice core samples is typically carried out by ion chromatography. Former methods, whilst providing suitable detection limits, have been based upon off-column preconcentration techniques, requiring larger sample volumes, with potential for sample contamination and/or carryover. Here, a new capillary ion chromatography based analytical method has been developed for quantitative analysis of limited volume Antarctic ice core samples. The developed analytical protocol applies capillary ion chromatography (with suppressed conductivity detection) and direct on-column sample injection and focusing, thus eliminating the requirement for off-column sample preconcentration. This limits the total sample volume needed to 300μL per analysis, allowing for triplicate sample analysis with <1mL of sample. This new approach provides a reliable and robust analytical method for the simultaneous determination of organic and inorganic anions, including fluoride, methanesulfonate, chloride, sulfate and nitrate anions. Application to composite ice-core samples is demonstrated, with coupling of the capillary ion chromatograph to high resolution mass spectrometry used to confirm the presence and purity of the observed methanesulfonate peak. Copyright © 2015 Elsevier B.V. All rights reserved.

50 CFR 660.220 - Fixed gear fishery-crossover provisions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... to the trip limits for black rockfish off Washington (see § 660.230(d)). (1) Going from a more... limit for the entire period to which that trip limit applies, no matter where the fish are taken and... for the entire period to which that trip limit applies, no matter where the fish are taken and...

50 CFR 660.220 - Fixed gear fishery-crossover provisions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... to the trip limits for black rockfish off Washington (see § 660.230(d)). (1) Going from a more... limit for the entire period to which that trip limit applies, no matter where the fish are taken and... for the entire period to which that trip limit applies, no matter where the fish are taken and...

Bile acid profiling and quantification in biofluids using ultra-performance liquid chromatography tandem mass spectrometry.

PubMed

Sarafian, Magali H; Lewis, Matthew R; Pechlivanis, Alexandros; Ralphs, Simon; McPhail, Mark J W; Patel, Vishal C; Dumas, Marc-Emmanuel; Holmes, Elaine; Nicholson, Jeremy K

2015-10-06

Bile acids are important end products of cholesterol metabolism. While they have been identified as key factors in lipid emulsification and absorption due to their detergent properties, bile acids have also been shown to act as signaling molecules and intermediates between the host and the gut microbiota. To further the investigation of bile acid functions in humans, an advanced platform for high throughput analysis is essential. Herein, we describe the development and application of a 15 min UPLC procedure for the separation of bile acid species from human biofluid samples requiring minimal sample preparation. High resolution time-of-flight mass spectrometry was applied for profiling applications, elucidating rich bile acid profiles in both normal and disease state plasma. In parallel, a second mode of detection was developed utilizing tandem mass spectrometry for sensitive and quantitative targeted analysis of 145 bile acid (BA) species including primary, secondary, and tertiary bile acids. The latter system was validated by testing the linearity (lower limit of quantification, LLOQ, 0.25-10 nM and upper limit of quantification, ULOQ, 2.5-5 μM), precision (≈6.5%), and accuracy (81.2-118.9%) on inter- and intraday analysis achieving good recovery of bile acids (serum/plasma 88% and urine 93%). The ultra performance liquid chromatography-mass spectrometry (UPLC-MS)/MS targeted method was successfully applied to plasma, serum, and urine samples in order to compare the bile acid pool compositional difference between preprandial and postprandial states, demonstrating the utility of such analysis on human biofluids.

Fulfillment of GMP standard, halal standard, and applying HACCP for production process of beef floss (Case study: Ksatria enterprise)

NASA Astrophysics Data System (ADS)

A'diat, Arkan Addien Al; Liquiddanu, Eko; Laksono, Pringgo Widyo; Sutopo, Wahyudi; Suletra, I. Wayan

2018-02-01

Along with the increasing number of the modern retail business in Indonesia, give an opportunity to small and medium enterprise (SME) to sell its products through the modern retailer. There are some obstacles faced by the SMEs, one of them is about product standard. Product standard that must be owned by SMEs are GMP standard and halal standard. This research was conducted to know the fulfillment by the beef floss enterprise in jagalan in fulfilling the GMP standard and halal. In addition, Hazard Analysis and Critical Control Points (HACCP) system was applied to analyze the process. HACCP which used in this research was based on the seven principles in SNI (Indonesian National Standard) 01-4852-1998. The seven principles included hazard analysis, critical control point (CCP) determination, critical limit establishment, CCP monitor system establishment, corrective action establishment, verification, and also documentation establishment that must be applied in preparing HACCP plan. Based on this case study, it is concluded that there were 5 CCPs : the boiling process, roasting process, frying process, the beef floss draining process, and the packaging process.

Analytic prediction of unconfined boundary layer flashback limits in premixed hydrogen-air flames

NASA Astrophysics Data System (ADS)

Hoferichter, Vera; Hirsch, Christoph; Sattelmayer, Thomas

2017-05-01

Flame flashback is a major challenge in premixed combustion. Hence, the prediction of the minimum flow velocity to prevent boundary layer flashback is of high technical interest. This paper presents an analytic approach to predicting boundary layer flashback limits for channel and tube burners. The model reflects the experimentally observed flashback mechanism and consists of a local and global analysis. Based on the local analysis, the flow velocity at flashback initiation is obtained depending on flame angle and local turbulent burning velocity. The local turbulent burning velocity is calculated in accordance with a predictive model for boundary layer flashback limits of duct-confined flames presented by the authors in an earlier publication. This ensures consistency of both models. The flame angle of the stable flame near flashback conditions can be obtained by various methods. In this study, an approach based on global mass conservation is applied and is validated using Mie-scattering images from a channel burner test rig at ambient conditions. The predicted flashback limits are compared to experimental results and to literature data from preheated tube burner experiments. Finally, a method for including the effect of burner exit temperature is demonstrated and used to explain the discrepancies in flashback limits obtained from different burner configurations reported in the literature.

40 CFR 433.13 - Effluent limitations representing the degree of effluent reduction attainable by applying the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... Monthly average shall not exceed Milligrams per liter (mg/l) Cadmium (T) 0.69 0.26 Chromium (T) 2.77 1.71... those limits and the pollution control authority, the following amenable cyanide limit may apply in...

40 CFR 433.13 - Effluent limitations representing the degree of effluent reduction attainable by applying the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Monthly average shall not exceed Milligrams per liter (mg/l) Cadmium (T) 0.69 0.26 Chromium (T) 2.77 1.71... those limits and the pollution control authority, the following amenable cyanide limit may apply in...

Limit on Neutrinoless Double Beta Decay of 76Ge by GERDA

NASA Astrophysics Data System (ADS)

Agostini, M.; Allardt, M.; Andreotti, E.; Bakalyarov, A. M.; Balata, M.; Barabanov, I.; Heider, M. Barabè; Barros, N.; Baudis, L.; Bauer, C.; Becerici-Schmidt, N.; Bellotti, E.; Belogurov, S.; Belyaev, S. T.; Benato, G.; Bettini, A.; Bezrukov, L.; Bode, T.; Brudanin, V.; Brugnera, R.; Budjáš, D.; Caldwell, A.; Cattadori, C.; Chernogorov, A.; Cossavella, F.; Demidova, E. V.; Domula, A.; Egorov, V.; Falkenstein, R.; Ferella, A.; Freund, K.; Frodyma, N.; Gangapshev, A.; Garfagnini, A.; Gotti, C.; Grabmayr, P.; Gurentsov, V.; Gusev, K.; Guthikonda, K. K.; Hampel, W.; Hegai, A.; Heisel, M.; Hemmer, S.; Heusser, G.; Hofmann, W.; Hult, M.; Inzhechik, L. V.; Csáthy, J. Janicskó; Jochum, J.; Junker, M.; Kihm, T.; Kirpichnikov, I. V.; Kirsch, A.; Klimenko, A.; Knöpfle, K. T.; Kochetov, O.; Kornoukhov, V. N.; Kuzminov, V. V.; Laubenstein, M.; Lazzaro, A.; Lebedev, V. I.; Lehnert, B.; Liao, H. Y.; Lindner, M.; Lippi, I.; Lubashevskiy, A.; Lubsandorzhiev, B.; Lutter, G.; Machado, A. A.; Macolino, C.; Majorovits, B.; Maneschg, W.; Misiaszek, M.; Nemchenok, I.; Nisi, S.; Shaughnessy, C. O.'.; Pandola, L.; Pelczar, K.; Pessina, G.; Pullia, A.; Riboldi, S.; Rumyantseva, N.; Sada, C.; Salathe, M.; Schmitt, C.; Schreiner, J.; Schulz, O.; Schwingenheuer, B.; Schönert, S.; Shevchik, E.; Shirchenko, M.; Simgen, H.; Smolnikov, A.; Stanco, L.; Strecker, H.; Tarka, M.; Ur, C. A.; Vasenko, A. A.; Volynets, O.; von Sturm, K.; Wagner, V.; Walter, M.; Wegmann, A.; Wester, T.; Wojcik, M.; Yanovich, E.; Zavarise, P.; Zhitnikov, I.; Zhukov, S. V.; Zinatulina, D.; Zuber, K.; Zuzel, G.

The Gerda experiment at the Laboratori Nazionali del Gran Sasso in Italy uses germanium detectors made from material with an enriched 76Ge isotope fraction to search for neutrinoless double beta decay of this nucleus. Applying a blind analysis we find no signal after an exposure of 21.6 kg·yr and a background of about 0.01 cts/(keV·kg·yr). A half-life limit of Tov1/2> 2.1 · 1025 yr (90% C.L.) is extracted. The previous claim of a signal for 76Ge is excluded with 99% probability in a model independent way.

Design and Test of an Improved Crashworthiness Small Composite Airframe

NASA Technical Reports Server (NTRS)

Terry, James E.; Hooper, Steven J.; Nicholson, Mark

2002-01-01

The purpose of this small business innovative research (SBIR) program was to evaluate the feasibility of developing small composite airplanes with improved crashworthiness. A combination of analysis and half scale component tests were used to develop an energy absorbing airframe. Four full scale crash tests were conducted at the NASA Impact Dynamics Research Facility, two on a hard surface and two onto soft soil, replicating earlier NASA tests of production general aviation airplanes. Several seat designs and restraint systems including both an air bag and load limiting shoulder harnesses were tested. Tests showed that occupant loads were within survivable limits with the improved structural design and the proper combination of seats and restraint systems. There was no loss of cabin volume during the events. The analysis method developed provided design guidance but time did not allow extending the analysis to soft soil impact. This project demonstrated that survivability improvements are possible with modest weight penalties. The design methods can be readily applied by airplane designers using the examples in this report.

Simplified RP-HPLC method for multi-residue analysis of abamectin, emamectin benzoate and ivermectin in rice.

PubMed

Xie, Xianchuan; Gong, Shu; Wang, Xiaorong; Wu, Yinxing; Zhao, Li

2011-01-01

A rapid, reliable and sensitive reverse-phase high-performance liquid chromatography method with fluorescence detection (RP-FLD-HPLC) was developed and validated for simultaneous analysis of the abamectin (ABA), emamectin (EMA) benzoate and ivermectin (IVM) residues in rice. After extraction with acetonitrile/water (2 : 1) with sonication, the avermectin (AVMs) residues were directly derivatised by N-methylimidazole (N-NMIM) and trifluoroacetic anhydride (TFAA) and then analysed on RP-FLD-HPLC. A good linear relationship (r(2 )> 0.99) was obtained for three AVMs ranging from 0.01 to 5 microg ml(-1), i.e. 0.01-5.0 microg g(-1) in rice matrix. The limit of detection (LOD) and the limit of quantification (LOQ) were between 0.001 and 0.002 microg g(-1) and between 0.004 and 0.006 microg g(-1), respectively. Recoveries were from 81.9% to 105.4% and precision less than 12.4%. The proposed method was successfully applied to routine analysis of the AVMs residues in rice.

Interpolation of longitudinal shape and image data via optimal mass transport

NASA Astrophysics Data System (ADS)

Gao, Yi; Zhu, Liang-Jia; Bouix, Sylvain; Tannenbaum, Allen

2014-03-01

Longitudinal analysis of medical imaging data has become central to the study of many disorders. Unfortunately, various constraints (study design, patient availability, technological limitations) restrict the acquisition of data to only a few time points, limiting the study of continuous disease/treatment progression. Having the ability to produce a sensible time interpolation of the data can lead to improved analysis, such as intuitive visualizations of anatomical changes, or the creation of more samples to improve statistical analysis. In this work, we model interpolation of medical image data, in particular shape data, using the theory of optimal mass transport (OMT), which can construct a continuous transition from two time points while preserving "mass" (e.g., image intensity, shape volume) during the transition. The theory even allows a short extrapolation in time and may help predict short-term treatment impact or disease progression on anatomical structure. We apply the proposed method to the hippocampus-amygdala complex in schizophrenia, the heart in atrial fibrillation, and full head MR images in traumatic brain injury.

Real-time detection of hazardous materials in air

NASA Astrophysics Data System (ADS)

Schechter, Israel; Schroeder, Hartmut; Kompa, Karl L.

1994-03-01

A new detection system has been developed for real-time analysis of organic compounds in ambient air. It is based on multiphoton ionization by an unfocused laser beam in a single parallel-plate device. Thus, the ionization volume can be relatively large. The amount of laser created ions is determined quantitatively from the induced total voltage drop between the biased plates (Q equals (Delta) V(DOT)C). Mass information is obtained from computer analysis of the time-dependent signal. When a KrF laser (5 ev) is used, most of the organic compounds can be ionized in a two-photon process, but none of the standard components of atmospheric air are ionized by this process. Therefore, this instrument may be developed as a `sniffer' for organic materials. The method has been applied for benzene analysis in air. The detection limit is about 10 ppb. With a simple preconcentration technique the detection limit can be decreased to the sub-ppb range. Simple binary mixtures are also resolved.

Minding the Cyber-Physical Gap: Model-Based Analysis and Mitigation of Systemic Perception-Induced Failure.

PubMed

Mordecai, Yaniv; Dori, Dov

2017-07-17

The cyber-physical gap (CPG) is the difference between the 'real' state of the world and the way the system perceives it. This discrepancy often stems from the limitations of sensing and data collection technologies and capabilities, and is inevitable at some degree in any cyber-physical system (CPS). Ignoring or misrepresenting such limitations during system modeling, specification, design, and analysis can potentially result in systemic misconceptions, disrupted functionality and performance, system failure, severe damage, and potential detrimental impacts on the system and its environment. We propose CPG-Aware Modeling & Engineering (CPGAME), a conceptual model-based approach to capturing, explaining, and mitigating the CPG. CPGAME enhances the systems engineer's ability to cope with CPGs, mitigate them by design, and prevent erroneous decisions and actions. We demonstrate CPGAME by applying it for modeling and analysis of the 1979 Three Miles Island 2 nuclear accident, and show how its meltdown could be mitigated. We use ISO-19450:2015-Object Process Methodology as our conceptual modeling framework.

Selection Metric for Photovoltaic Materials Screening Based on Detailed-Balance Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blank, Beatrix; Kirchartz, Thomas; Lany, Stephan

The success of recently discovered absorber materials for photovoltaic applications has been generating increasing interest in systematic materials screening over the last years. However, the key for a successful materials screening is a suitable selection metric that goes beyond the Shockley-Queisser theory that determines the thermodynamic efficiency limit of an absorber material solely by its band-gap energy. Here, we develop a selection metric to quantify the potential photovoltaic efficiency of a material. Our approach is compatible with detailed balance and applicable in computational and experimental materials screening. We use the complex refractive index to calculate radiative and nonradiative efficiency limitsmore » and the respective optimal thickness in the high mobility limit. We also compare our model to the widely applied selection metric by Yu and Zunger [Phys. Rev. Lett. 108, 068701 (2012)] with respect to their dependence on thickness, internal luminescence quantum efficiency, and refractive index. Finally, the model is applied to complex refractive indices calculated via electronic structure theory.« less

Development and validation of an MEKC method for determination of nitrogen-containing drugs in pharmaceutical preparations.

PubMed

Buiarelli, Francesca; Coccioli, Franco; Jasionowska, Renata; Terracciano, Alessandro

2008-09-01

A fast and accurate micellar electrokinetic capillary chromatography method was developed for quality control of pharmaceutical preparations containing cold remedies as acetaminophen, salicylamide, caffeine, phenylephrine, pseudoephedrine, norephedrine and chlorpheniramine. The method optimization was realized on a Beckman P/ACE System MDQ instrument. The baseline separation of seven analytes was performed in an uncoated fused silica capillary internal diameter (ID)=50 microm using tris-borate (20 mM, pH=8.5) containing sodium dodecyl sulphate 30 mM BGE. On line-UV detection at 214 nm was performed and the applied voltage was 10 kV. The operating temperature was 25 degrees C. After experimental conditions optimization, the proposed method was validated. The evaluated parameters were: precision of migration time and of corrected peak area ratio, linearity range, limit of detection, limit of quantification, accuracy (recovery), ruggedness and applicability. The method was then successfully applied for the analysis of three pharmaceutical preparations containing some of the analytes listed before.

Selection Metric for Photovoltaic Materials Screening Based on Detailed-Balance Analysis

DOE PAGES

Blank, Beatrix; Kirchartz, Thomas; Lany, Stephan; ...

2017-08-31

The success of recently discovered absorber materials for photovoltaic applications has been generating increasing interest in systematic materials screening over the last years. However, the key for a successful materials screening is a suitable selection metric that goes beyond the Shockley-Queisser theory that determines the thermodynamic efficiency limit of an absorber material solely by its band-gap energy. Here, we develop a selection metric to quantify the potential photovoltaic efficiency of a material. Our approach is compatible with detailed balance and applicable in computational and experimental materials screening. We use the complex refractive index to calculate radiative and nonradiative efficiency limitsmore » and the respective optimal thickness in the high mobility limit. We also compare our model to the widely applied selection metric by Yu and Zunger [Phys. Rev. Lett. 108, 068701 (2012)] with respect to their dependence on thickness, internal luminescence quantum efficiency, and refractive index. Finally, the model is applied to complex refractive indices calculated via electronic structure theory.« less

Design and Simulation of an Electrothermal Actuator Based Rotational Drive

NASA Astrophysics Data System (ADS)

Beeson, Sterling; Dallas, Tim

2008-10-01

As a participant in the Micro and Nano Device Engineering (MANDE) Research Experience for Undergraduates program at Texas Tech University, I learned how MEMS devices operate and the limits of their operation. Using specialized AutoCAD-based design software and the ANSYS simulation program, I learned the MEMS fabrication process used at Sandia National Labs, the design limitations of this process, the abilities and drawbacks of micro devices, and finally, I redesigned a MEMS device called the Chevron Torsional Ratcheting Actuator (CTRA). Motion is achieved through electrothermal actuation. The chevron (bent-beam) actuators cause a ratcheting motion on top of a hub-less gear so that as voltage is applied the CTRA spins. The voltage applied needs to be pulsed and the frequency of the pulses determine the angular frequency of the device. The main objective was to design electromechanical structures capable of transforming the electrical signals into mechanical motion without overheating. The design was optimized using finite element analysis in ANSYS allowing multi-physics simulations of our model system.

Enhancing the sensitivity of mid-IR quantum cascade laser-based cavity-enhanced absorption spectroscopy using RF current perturbation.

PubMed

Manfred, Katherine M; Kirkbride, James M R; Ciaffoni, Luca; Peverall, Robert; Ritchie, Grant A D

2014-12-15

The sensitivity of mid-IR quantum cascade laser (QCL) off-axis cavity-enhanced absorption spectroscopy (CEAS), often limited by cavity mode structure and diffraction losses, was enhanced by applying a broadband RF noise to the laser current. A pump-probe measurement demonstrated that the addition of bandwidth-limited white noise effectively increased the laser linewidth, thereby reducing mode structure associated with CEAS. The broadband noise source offers a more sensitive, more robust alternative to applying single-frequency noise to the laser. Analysis of CEAS measurements of a CO(2) absorption feature at 1890  cm(-1) averaged over 100 ms yielded a minimum detectable absorption of 5.5×10(-3)  Hz(-1/2) in the presence of broadband RF perturbation, nearly a tenfold improvement over the unperturbed regime. The short acquisition time makes this technique suitable for breath applications requiring breath-by-breath gas concentration information.

Acousto-optic replication of ultrashort laser pulses

NASA Astrophysics Data System (ADS)

Yushkov, Konstantin B.; Molchanov, Vladimir Ya.; Ovchinnikov, Andrey V.; Chefonov, Oleg V.

2017-10-01

Precisely controlled sequences of ultrashort laser pulses are required in various scientific and engineering applications. We developed a phase-only acousto-optic pulse shaping method for replication of ultrashort laser pulses in a TW laser system. A sequence of several Fourier-transform-limited pulses is generated from a single femtosecond laser pulse by means of applying a piecewise linear phase modulation over the whole emission spectrum. Analysis demonstrates that the main factor which limits maximum delay between the pulse replicas is spectral resolution of the acousto-optic dispersive delay line used for pulse shaping. In experiments with a Cr:forsterite laser system, we obtained delays from 0.3 to 3.5 ps between two replicas of 190 fs transform-limited pulses at the central wavelength of laser emission, 1230 nm.

Addressing challenging behaviour in children with Down syndrome: the use of applied behaviour analysis for assessment and intervention.

PubMed

Feeley, Kathleen M; Jones, Emily A

2006-09-01

Children with Down syndrome are at an increased risk for engaging in challenging behaviour that may be part of a behavioural phenotype characteristic of Down syndrome. The methodology of applied behaviour analysis has been demonstrated effective with a wide range of challenging behaviours, across various disabilities. Applications to children with Down syndrome and the examination of behaviourally based strategies to specifically address the unique characteristics of children with Down syndrome are limited. However, there are several studies in which a subset of the participants did have Down syndrome. A handful of these studies are reviewed within the context of functional behaviour assessment and Positive Behavioural Supports. Drawing from these studies and the behavioural literature, as well as the authors' clinical experience and research, suggestions regarding early intervention for challenging behaviour with children with Down syndrome are provided.

Mass spectrometry in plant metabolomics strategies: from analytical platforms to data acquisition and processing.

PubMed

Ernst, Madeleine; Silva, Denise Brentan; Silva, Ricardo Roberto; Vêncio, Ricardo Z N; Lopes, Norberto Peporine

2014-06-01

Covering: up to 2013. Plant metabolomics is a relatively recent research field that has gained increasing interest in the past few years. Up to the present day numerous review articles and guide books on the subject have been published. This review article focuses on the current applications and limitations of the modern mass spectrometry techniques, especially in combination with electrospray ionisation (ESI), an ionisation method which is most commonly applied in metabolomics studies. As a possible alternative to ESI, perspectives on matrix-assisted laser desorption/ionisation mass spectrometry (MALDI-MS) in metabolomics studies are introduced, a method which still is not widespread in the field. In metabolomics studies the results must always be interpreted in the context of the applied sampling procedures as well as data analysis. Different sampling strategies are introduced and the importance of data analysis is illustrated in the example of metabolic network modelling.

Thermal radiation characteristics of nonisothermal cylindrical enclosures using a numerical ray tracing technique

NASA Technical Reports Server (NTRS)

Baumeister, Joseph F.

1990-01-01

Analysis of energy emitted from simple or complex cavity designs can lead to intricate solutions due to nonuniform radiosity and irradiation within a cavity. A numerical ray tracing technique was applied to simulate radiation propagating within and from various cavity designs. To obtain the energy balance relationships between isothermal and nonisothermal cavity surfaces and space, the computer code NEVADA was utilized for its statistical technique applied to numerical ray tracing. The analysis method was validated by comparing results with known theoretical and limiting solutions, and the electrical resistance network method. In general, for nonisothermal cavities the performance (apparent emissivity) is a function of cylinder length-to-diameter ratio, surface emissivity, and cylinder surface temperatures. The extent of nonisothermal conditions in a cylindrical cavity significantly affects the overall cavity performance. Results are presented over a wide range of parametric variables for use as a possible design reference.

Low thermal diffusivity measurements of thin films using mirage technique

NASA Astrophysics Data System (ADS)

Wong, P. K.; Fung, P. C. W.; Tam, H. L.

1998-12-01

Mirage technique is proved to be powerful in measurements of thermal diffusivity. Its contactless nature makes it suitable for delicate samples such as thin films and single crystals. However, as the damping of the thermal wave profile increases progressively upon the decrease in thermal diffusivity of the medium, mirage technique becomes more difficult to be applied to low thermal diffusivity measurements. Moreover influences from substrate signals make analysis difficult when the samples are thermally thin. Recently a thermal-wave-coupling method for mirage signal analysis [P. K. Wong, P. C. W. Fung, H. L. Tam, and J. Gao, Phys. Rev. B 51, 523 (1995)] was reported for thermal diffusivity measurements of thin film down to 60 nm thick. In this article we apply the thermal-wave-coupling method to thin films of low thermal diffusivity, especially polymer films. A new lower limit of thermal diffusivity measurable by mirage technique has been reached.

The Contribution of Particle Swarm Optimization to Three-Dimensional Slope Stability Analysis

PubMed Central

A Rashid, Ahmad Safuan; Ali, Nazri

2014-01-01

Over the last few years, particle swarm optimization (PSO) has been extensively applied in various geotechnical engineering including slope stability analysis. However, this contribution was limited to two-dimensional (2D) slope stability analysis. This paper applied PSO in three-dimensional (3D) slope stability problem to determine the critical slip surface (CSS) of soil slopes. A detailed description of adopted PSO was presented to provide a good basis for more contribution of this technique to the field of 3D slope stability problems. A general rotating ellipsoid shape was introduced as the specific particle for 3D slope stability analysis. A detailed sensitivity analysis was designed and performed to find the optimum values of parameters of PSO. Example problems were used to evaluate the applicability of PSO in determining the CSS of 3D slopes. The first example presented a comparison between the results of PSO and PLAXI-3D finite element software and the second example compared the ability of PSO to determine the CSS of 3D slopes with other optimization methods from the literature. The results demonstrated the efficiency and effectiveness of PSO in determining the CSS of 3D soil slopes. PMID:24991652

The contribution of particle swarm optimization to three-dimensional slope stability analysis.

PubMed

Kalatehjari, Roohollah; Rashid, Ahmad Safuan A; Ali, Nazri; Hajihassani, Mohsen

2014-01-01

Over the last few years, particle swarm optimization (PSO) has been extensively applied in various geotechnical engineering including slope stability analysis. However, this contribution was limited to two-dimensional (2D) slope stability analysis. This paper applied PSO in three-dimensional (3D) slope stability problem to determine the critical slip surface (CSS) of soil slopes. A detailed description of adopted PSO was presented to provide a good basis for more contribution of this technique to the field of 3D slope stability problems. A general rotating ellipsoid shape was introduced as the specific particle for 3D slope stability analysis. A detailed sensitivity analysis was designed and performed to find the optimum values of parameters of PSO. Example problems were used to evaluate the applicability of PSO in determining the CSS of 3D slopes. The first example presented a comparison between the results of PSO and PLAXI-3D finite element software and the second example compared the ability of PSO to determine the CSS of 3D slopes with other optimization methods from the literature. The results demonstrated the efficiency and effectiveness of PSO in determining the CSS of 3D soil slopes.

New Insights into Signed Path Coefficient Granger Causality Analysis

PubMed Central

Zhang, Jian; Li, Chong; Jiang, Tianzi

2016-01-01

Granger causality analysis, as a time series analysis technique derived from econometrics, has been applied in an ever-increasing number of publications in the field of neuroscience, including fMRI, EEG/MEG, and fNIRS. The present study mainly focuses on the validity of “signed path coefficient Granger causality,” a Granger-causality-derived analysis method that has been adopted by many fMRI researches in the last few years. This method generally estimates the causality effect among the time series by an order-1 autoregression, and defines a positive or negative coefficient as an “excitatory” or “inhibitory” influence. In the current work we conducted a series of computations from resting-state fMRI data and simulation experiments to illustrate the signed path coefficient method was flawed and untenable, due to the fact that the autoregressive coefficients were not always consistent with the real causal relationships and this would inevitablely lead to erroneous conclusions. Overall our findings suggested that the applicability of this kind of causality analysis was rather limited, hence researchers should be more cautious in applying the signed path coefficient Granger causality to fMRI data to avoid misinterpretation. PMID:27833547

Registration factors that limit international mobility of people holding physiotherapy qualifications: A systematic review.

PubMed

Foo, Jonathan S; Storr, Michael; Maloney, Stephen

2016-06-01

There is no enforced international standardisation of the physiotherapy profession. Thus, registration is used in many countries to maintain standards of care and to protect the public. However, registration may also limit international workforce mobility. What is known about the professional registration factors that may limit the international mobility of people holding physiotherapy qualifications? Systematic review using an electronic database search and hand searching of the World Confederation for Physical Therapy and International Network of Physiotherapy Regulatory Authorities websites. Analysis was conducted using thematic analysis. 10 articles and eight websites were included from the search strategy. Data is representative of high-income English speaking countries. Four themes emerged regarding limitations to professional mobility: practice context, qualification recognition, verification of fitness to practice, and incidental limitations arising from the registration process. Professional mobility is limited by differences in physiotherapy education programmes, resulting in varying standards of competency. Thus, it is often necessary to verify clinical competencies through assessments, as well as determining professional attributes and ability to apply competencies in a different practice context, as part of the registration process. There has been little evaluation of registration practices, and at present, there is a need to re-evaluate current registration processes to ensure they are efficient and effective, thereby enhancing workforce mobility. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

An Evaluation of the Generalization and Maintenance Outcomes of a Competency-Based Training Program Aligned with the BACB® Registered Behavior Technician™ Task List

ERIC Educational Resources Information Center

Forte, Solandy

2017-01-01

It is often necessary for the behavior analyst practitioner to work across a variety of settings, including home, school, and community, in which it is common practice for those practitioners to provide training to caregivers and direct-care staff, who may have limited knowledge and experience within the field of applied behavior analysis. A…

A Classification and Analysis of Contracting Literature

DTIC Science & Technology

1989-12-01

Pricing Model ( CAPM . This is a model designed by investment analysts to determine required rates of return given the systematic risk of a company. The...For the amount of risk they take, these profit margins were not excessively high. The author examined profitability in terms of the Capital Asset ...taxonomy was applied was limited , the results were necessarily qualified. However, at the least this application provided areas for further research

Comparison of different mass spectrometric approaches coupled to gas chromatography for the analysis of organochlorine pesticides in serum samples.

PubMed

Fang, Jing; Wu, Qian; Zhao, Yun; Zhao, Hongzhi; Xu, Shunqing; Cai, Zongwei

2017-01-01

Gas chromatography-triple quadrupole mass spectrometry (GC-QqQMS) was applied for the determination of eight organochlorine pesticides (OCPs) in human serum. OCPs were extracted from the serum sample by solid phase extraction (SPE) and analyzed by gas chromatography mass spectrometry (GC-MS) or gas chromatography tandem mass spectrometry (GC-MS/MS). Electron ionization (EI) and negative chemical ionization (NCI) under two data acquisition modes, namely selected ion monitoring (SIM) and multiple reaction monitoring (MRM), were compared. The use of MRM generally provided higher selectivity and sensitivity because less interference from the sample matrix existed. The EI mode is more suitable for less electronegative compounds such as dichlorodiphenyldichloroethanes (DDDs) with detection limits ranging from 0.0060 to 0.060ng/mL. In the NCI mode, MRM analysis provided good and lower detection limits (0.0011-0.0030ng/mL) for pesticides containing more chlorines. The methods were validated by analyzing the pesticides in spiked serum at different levels with recoveries ranged from 83% to 116% and relative standard deviations of less than 10%. The developed method was applied for the determination of the OCPs in real human serum samples. Copyright © 2016 Elsevier B.V. All rights reserved.

Complex self-management interventions in chronic disease unravelled: a review of lessons learned from an individual patient data meta-analysis.

PubMed

Jonkman, Nini H; Groenwold, Rolf H H; Trappenburg, Jaap C A; Hoes, Arno W; Schuurmans, Marieke J

2017-03-01

Meta-analyses using individual patient data (IPD) rather than aggregated data are increasingly applied to analyze sources of heterogeneity between trials and have only recently been applied to unravel multicomponent, complex interventions. This study reflects on methodological challenges encountered in two IPD meta-analyses on self-management interventions in patients with heart failure or chronic obstructive pulmonary disease. Critical reflection on prior IPD meta-analyses and discussion of literature. Experience from two IPD meta-analyses illustrates methodological challenges. Despite close collaboration with principal investigators, assessing the effect of characteristics of complex interventions on the outcomes of trials is compromised by lack of sufficient details on intervention characteristics and limited data on fidelity and adherence. Furthermore, trials collected baseline variables in a highly diverse way, limiting the possibilities to study subgroups of patients in a consistent manner. Possible solutions are proposed based on lessons learnt from the methodological challenges. Future researchers of complex interventions should pay considerable attention to the causal mechanism underlying the intervention and conducting process evaluations. Future researchers on IPD meta-analyses of complex interventions should carefully consider their own causal assumptions and availability of required data in eligible trials before undertaking such resource-intensive IPD meta-analysis. Copyright © 2017 Elsevier Inc. All rights reserved.

Orthopedic, ophthalmic, and psychiatric diseases primarily affect activity limitation for Japanese males and females: Based on the Comprehensive Survey of Living Conditions.

PubMed

Myojin, Tomoya; Ojima, Toshiyuki; Kikuchi, Keiko; Okada, Eisaku; Shibata, Yosuke; Nakamura, Mieko; Hashimoto, Shuji

2017-02-01

Healthy life expectancy (HLE) is used as one of the primary objectives of fundamental health promotion plans and social development plans. Activity limitation is used to calculate HLE, but little study has been done to identify determinants of activity limitation in order to extend HLE. The purpose of this study is to identify diseases and injuries that commonly lead to activity limitation to prioritize countermeasures against activity limitation. We used anonymous data from the 2007 "Comprehensive Survey of Living Conditions," collected by the Ministry of Health, Labour and Welfare of Japan according to the Statistics Act, Article 36. We used logistic regression analyses and calculated odds ratios (ORs) after adjusting for age and sex. Limitation in daily activities was applied as the dependent variable, and each disease/injury was applied as an independent variable in this analysis. Furthermore, population attributable fractions (PAFs) were calculated. The provided data included 98,789 subjects. We used data for 75,986 valid subjects aged 12 years or older. The following diseases showed high PAF: backache (PAF 13.27%, OR 3.88), arthropathia (PAF 7.61%, OR 4.82), eye and optical diseases (PAF 6.39%, OR 2.01), and depression and other mental diseases (PAF 5.70%, OR 11.55). PAFs of cerebrovascular diseases, hypertension, and diabetes were higher for males than for females; on the other hand, PAFs of orthopedic diseases were higher among females. Our results indicate that orthopedic diseases, ophthalmic diseases, and psychiatric diseases particularly affect activity limitation. Copyright © 2016 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

Analysis of antithyroid drugs in surface water by using liquid chromatography-tandem mass spectrometry.

PubMed

Pérez-Fernández, Virginia; Marchese, Stefano; Gentili, Alessandra; García, María Ángeles; Curini, Roberta; Caretti, Fulvia; Perret, Daniela

2014-11-07

This paper describes development and validation of a new method for the simultaneous determination of six antithyroid drugs (ATDs) in surface waters by using liquid chromatography-triple quadrupole mass spectrometry (LC-MS/MS). Target compounds include two ATD classes: thiouracil derivatives (thiouracil (TU), methyl-thiouracil (MTU), propyl-thiouracil (PTU), phenyl-thiouracil (PhTU)) and imidazole derivatives (tapazole (TAP), and mercaptobenzimidazole (MBI)). Sensitivity and selectivity of the LC-multiple reaction monitoring (MRM) analysis allowed applying a simple pre-concentration procedure and "shooting" the concentrated sample into the LC-MS/MS system without any other treatment. Recoveries were higher than 75% for all analytes. Intra-day precision and inter-day precision, calculated as relative standard deviation (RSD), were below 19 and 22%, respectively. Limits of detection (LODs) ranged from 0.05 to 0.25 μg/L; limits of quantitation (LOQs) varied between 0.15 and 0.75 μg/L. The validated method was successfully applied to the analysis of ATD residues in surface water samples collected from the Tiber River basin and three lakes of Lazio (central Italy). The analytes were quantified based on matrix-matched calibration curves with mercaptobenzimidazole-d4 (MBI-d4) as the internal standard (IS). The most widespread compound was TAP, one of the most common ATDs used in human medicine, but also TU and MBI were often detected in the analysed samples. Copyright © 2014 Elsevier B.V. All rights reserved.

Simple, fast and reliable liquid chromatographic and spectrophotometric methods for the determination of theophylline in urine, saliva and plasma samples.

PubMed

Charehsaz, Mohammad; Gürbay, Aylin; Aydin, Ahmet; Sahin, Gönül

2014-01-01

In this study, a high-performance liquid chromatographic method (HPLC) and UV spectrophotometric method were developed, validated and applied for the determination of theophylline in biological fluids. Liquid- liquid extraction is performed for isolation of the drug and elimination of plasma and saliva interferences. Urine samples were applied without any extraction. The chromatographic separation was achieved on a C18 column by using 60:40 methanol:water as mobile phase under isocratic conditions at a flow rate of 0.75 mL/min with UV detection at 280 nm in HPLC method. UV spectrophotometric analysis was performed at 275 nm. the limit of quantification: 1.1 µg/mL for urine, 1.9 µg/mL for saliva, 3.1 µg/mL for plasma; recovery: 94.85% for plasma, 100.45% for saliva, 101.39% for urine; intra-day precision: 0.22-2.33%, inter-day precision: 3.17-13.12%. Spectrophotometric analysis results were as follows: the limit of quantitation: 5.23 µg/mL for plasma, 8.7 µg/mL for urine; recovery: 98.27% for plasma, 95.25% for urine; intra-day precision: 2.37 - 3.00%, inter-day precision: 5.43-7.91%. It can be concluded that this validated HPLC method is easy, precise, accurate, sensitive and selective for determination of theophylline in biological samples. Also spectrophotometric analysis can be used where it can be applicable.

40 CFR 63.3004 - What definitions apply to this subpart?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Requirements and Information § 63.3004 What definitions apply to this subpart? Terms used in this subpart are... application vacuum exhaust means the exhaust from the vacuum system used to remove excess resin solution from... binds the fibers. Emission limitation means an emission limit, operating limit, or work practice...

40 CFR 63.3004 - What definitions apply to this subpart?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Requirements and Information § 63.3004 What definitions apply to this subpart? Terms used in this subpart are... application vacuum exhaust means the exhaust from the vacuum system used to remove excess resin solution from... binds the fibers. Emission limitation means an emission limit, operating limit, or work practice...

Report on FY15 Two-Bar Thermal Ratcheting Test Results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Yanli; Jetter, Robert I; Baird, Seth T

2015-06-22

Alloy 617 is a reference structural material for very high temperature components of advanced-gas cooled reactors with outlet temperatures in the range of . In order for designers to be able to use Alloy 617 for these high temperature components, Alloy 617 has to be approved for use in Section III (the nuclear section) of the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code. A plan has been developed to submit a draft code for Alloy 617 to ASME Section III by 2015. However, the current rules in Subsection NH* for the evaluation of strain limits andmore » creep-fatigue damage using simplified methods based on elastic analysis have been deemed inappropriate for Alloy 617 at temperatures above . The rationale for this exclusion is that at higher temperatures it is not feasible to decouple plasticity and creep deformation, which is the basis for the current simplified rules. This temperature, , is well below the temperature range of interest for this material in High Temperature Gas Cooled Reactor (HTGR) applications. The only current alternative is, thus, a full inelastic analysis which requires sophisticated material models which have been formulated but not yet verified. To address this issue, proposed code rules have been developed which are based on the use of elastic-perfectly plastic (EPP) analysis methods and which are expected to be applicable to very high temperatures. These newly proposed rules also address a long-term objective to provide an option for more simple, comprehensive and easily applied rules than the current so called simplified rules These two-bar tests discussed herein are part of an ongoing series of tests with cyclic loading at high temperatures using specimens representing key features of potential component designs. The initial focus of the two-bar ratcheting test program, to verify the procedure for evaluation of strain limits for Alloy 617 at very high temperatures, has been expanded to respond to guidance from ASME Code committees that the proposed EPP methodology should also apply to other Subsection NH materials throughout their allowed temperature range. To support these objectives, two suites of tests have been accomplished during this reporting period. One suite addresses the issue of the response of Alloy 617 at a lower temperature with tests in range of 500 800oC and a few at 350 650°C. The other suite addresses the response of SS316H up to its current maximum allowed temperature of 1500°F (815°C) In the two-bar test methodology, the two bars can be viewed as specimens taken out of a tubular component across the wall thickness representing the inner wall element and the outer wall element respectively. The two bars are alternately heated and cooled under sustained axial loading to generate ratcheting. A sustained hold time is introduced at the hot extreme of the cycle to capture the accelerated ratcheting and strain accumulation due to creep. Since the boundary conditions are a combination of strain control and load control it is necessary to use two coupled servo-controlled testing machines to achieve the key features of the two-bar representation of actual component behavior. Two-bar thermal ratcheting test results with combinations of applied mean stresses, transient temperature difference and heating and cooling rates were recorded. Tests performed at heating and cooling rates of 30°C/min are comparable to a strain rate of 10 ⁻⁵/sec. At high mean stresses in tension the direction of ratcheting was in-phase with the load, e.g. tensile strain ratcheting under high tensile loading; however, at lower loads, strain ratcheting in compression was observed under net tensile mean stresses. The strain accumulation was proportional to the applied thermal load. However, there was a narrow range of applied load in which the high applied thermal loading did not result in significant strain accumulation. Unfortunately, when the proposed EPP strain limit evaluation rules were applied to the loading history for the two-bar configuration, the predicted narrow range of low strain accumulation did not coincide with the experimental data. However, by the use of inelastic analysis in conjunction with an analytic experiment it was possible to show that the EPP strain limit code case rules could be applied to high temperature structures where the stress and temperature is not uniform throughout which is the general case. Interestingly, the suite of tests on Alloy 617 at the lower temperature range of 500°C to 800oC showed good agreement with the proposed EPP strain limit rules with a much wider band of applied load that exhibited minimal ratcheting. The four tests conducted at the lower temperature range of 350°C to 650°C showed no ratcheting. The suite of tests on SS316H at a temperature range of 515°C to 815°C resembled the results from the tests on Alloy 617 at 650°C to 950°C. Both exhibited a narrow band of applied load wher...« less

Gain optimization with non-linear controls

NASA Technical Reports Server (NTRS)

Slater, G. L.; Kandadai, R. D.

1984-01-01

An algorithm has been developed for the analysis and design of controls for non-linear systems. The technical approach is to use statistical linearization to model the non-linear dynamics of a system by a quasi-Gaussian model. A covariance analysis is performed to determine the behavior of the dynamical system and a quadratic cost function. Expressions for the cost function and its derivatives are determined so that numerical optimization techniques can be applied to determine optimal feedback laws. The primary application for this paper is centered about the design of controls for nominally linear systems but where the controls are saturated or limited by fixed constraints. The analysis is general, however, and numerical computation requires only that the specific non-linearity be considered in the analysis.

36 CFR 1254.82 - What limitations apply to my use of self-service card-operated copiers?

Code of Federal Regulations, 2012 CFR

2012-07-01

... limitations apply to my use of self-service card-operated copiers? (a) There is a 5-minute time limit on..., we may limit you to three copies when others are waiting to use the machine. If you wish to copy... for an extended time period. (b) If we must cancel an appointment due to copier failure, we make every...

36 CFR 1254.82 - What limitations apply to my use of self-service card-operated copiers?

Code of Federal Regulations, 2014 CFR

2014-07-01

... limitations apply to my use of self-service card-operated copiers? (a) There is a 5-minute time limit on..., we may limit you to three copies when others are waiting to use the machine. If you wish to copy... for an extended time period. (b) If we must cancel an appointment due to copier failure, we make every...

Spatial Ensemble Postprocessing of Precipitation Forecasts Using High Resolution Analyses

NASA Astrophysics Data System (ADS)

Lang, Moritz N.; Schicker, Irene; Kann, Alexander; Wang, Yong

2017-04-01

Ensemble prediction systems are designed to account for errors or uncertainties in the initial and boundary conditions, imperfect parameterizations, etc. However, due to sampling errors and underestimation of the model errors, these ensemble forecasts tend to be underdispersive, and to lack both reliability and sharpness. To overcome such limitations, statistical postprocessing methods are commonly applied to these forecasts. In this study, a full-distributional spatial post-processing method is applied to short-range precipitation forecasts over Austria using Standardized Anomaly Model Output Statistics (SAMOS). Following Stauffer et al. (2016), observation and forecast fields are transformed into standardized anomalies by subtracting a site-specific climatological mean and dividing by the climatological standard deviation. Due to the need of fitting only a single regression model for the whole domain, the SAMOS framework provides a computationally inexpensive method to create operationally calibrated probabilistic forecasts for any arbitrary location or for all grid points in the domain simultaneously. Taking advantage of the INCA system (Integrated Nowcasting through Comprehensive Analysis), high resolution analyses are used for the computation of the observed climatology and for model training. The INCA system operationally combines station measurements and remote sensing data into real-time objective analysis fields at 1 km-horizontal resolution and 1 h-temporal resolution. The precipitation forecast used in this study is obtained from a limited area model ensemble prediction system also operated by ZAMG. The so called ALADIN-LAEF provides, by applying a multi-physics approach, a 17-member forecast at a horizontal resolution of 10.9 km and a temporal resolution of 1 hour. The performed SAMOS approach statistically combines the in-house developed high resolution analysis and ensemble prediction system. The station-based validation of 6 hour precipitation sums shows a mean improvement of more than 40% in CRPS when compared to bilinearly interpolated uncalibrated ensemble forecasts. The validation on randomly selected grid points, representing the true height distribution over Austria, still indicates a mean improvement of 35%. The applied statistical model is currently set up for 6-hourly and daily accumulation periods, but will be extended to a temporal resolution of 1-3 hours within a new probabilistic nowcasting system operated by ZAMG.

Biomedical research competencies for osteopathic medical students

PubMed Central

Cruser, des Anges; Dubin, Bruce; Brown, Sarah K; Bakken, Lori L; Licciardone, John C; Podawiltz, Alan L; Bulik, Robert J

2009-01-01

Background Without systematic exposure to biomedical research concepts or applications, osteopathic medical students may be generally under-prepared to efficiently consume and effectively apply research and evidence-based medicine information in patient care. The academic literature suggests that although medical residents are increasingly expected to conduct research in their post graduate training specialties, they generally have limited understanding of research concepts. With grant support from the National Center for Complementary and Alternative Medicine, and a grant from the Osteopathic Heritage Foundation, the University of North Texas Health Science Center (UNTHSC) is incorporating research education in the osteopathic medical school curriculum. The first phase of this research education project involved a baseline assessment of students' understanding of targeted research concepts. This paper reports the results of that assessment and discusses implications for research education during medical school. Methods Using a novel set of research competencies supported by the literature as needed for understanding research information, we created a questionnaire to measure students' confidence and understanding of selected research concepts. Three matriculating medical school classes completed the on-line questionnaire. Data were analyzed for differences between groups using analysis of variance and t-tests. Correlation coefficients were computed for the confidence and applied understanding measures. We performed a principle component factor analysis of the confidence items, and used multiple regression analyses to explore how confidence might be related to the applied understanding. Results Of 496 total incoming, first, and second year medical students, 354 (71.4%) completed the questionnaire. Incoming students expressed significantly more confidence than first or second year students (F = 7.198, df = 2, 351, P = 0.001) in their ability to understand the research concepts. Factor analyses of the confidence items yielded conceptually coherent groupings. Regression analysis confirmed a relationship between confidence and applied understanding referred to as knowledge. Confidence scores were important in explaining variability in knowledge scores of the respondents. Conclusion Medical students with limited understanding of research concepts may struggle to understand the medical literature. Assessing medical students' confidence to understand and objectively measured ability to interpret basic research concepts can be used to incorporate competency based research material into the existing curriculum. PMID:19825171

A molecular beam/quadrupole mass spectrometer system with synchronized beam modulation and digital waveform analysis

NASA Technical Reports Server (NTRS)

Pellett, G. L.; Adams, B. R.

1983-01-01

A performance evaluation is conducted for a molecular beam/mass spectrometer (MB/MS) system, as applied to a 1-30 torr microwave-discharge flow reactor (MWFR) used in the formation of the methylperoxy radical and a study of its subsequent destruction in the presence or absence of NO(x). The modulated MB/MS system is four-staged and differentially pumped. The results obtained by the MWFR study is illustrative of overall system performance, including digital waveform analysis; significant improvements over previous designs are noted in attainable S/N ratio, detection limit, and accuracy.

Probabilistic finite elements for fatigue and fracture analysis

NASA Astrophysics Data System (ADS)

Belytschko, Ted; Liu, Wing Kam

Attenuation is focused on the development of Probabilistic Finite Element Method (PFEM), which combines the finite element method with statistics and reliability methods, and its application to linear, nonlinear structural mechanics problems and fracture mechanics problems. The computational tool based on the Stochastic Boundary Element Method is also given for the reliability analysis of a curvilinear fatigue crack growth. The existing PFEM's have been applied to solve for two types of problems: (1) determination of the response uncertainty in terms of the means, variance and correlation coefficients; and (2) determination the probability of failure associated with prescribed limit states.

Probabilistic finite elements for fatigue and fracture analysis

NASA Technical Reports Server (NTRS)

Belytschko, Ted; Liu, Wing Kam

1992-01-01

Attenuation is focused on the development of Probabilistic Finite Element Method (PFEM), which combines the finite element method with statistics and reliability methods, and its application to linear, nonlinear structural mechanics problems and fracture mechanics problems. The computational tool based on the Stochastic Boundary Element Method is also given for the reliability analysis of a curvilinear fatigue crack growth. The existing PFEM's have been applied to solve for two types of problems: (1) determination of the response uncertainty in terms of the means, variance and correlation coefficients; and (2) determination the probability of failure associated with prescribed limit states.

Kernel canonical-correlation Granger causality for multiple time series

NASA Astrophysics Data System (ADS)

Wu, Guorong; Duan, Xujun; Liao, Wei; Gao, Qing; Chen, Huafu

2011-04-01

Canonical-correlation analysis as a multivariate statistical technique has been applied to multivariate Granger causality analysis to infer information flow in complex systems. It shows unique appeal and great superiority over the traditional vector autoregressive method, due to the simplified procedure that detects causal interaction between multiple time series, and the avoidance of potential model estimation problems. However, it is limited to the linear case. Here, we extend the framework of canonical correlation to include the estimation of multivariate nonlinear Granger causality for drawing inference about directed interaction. Its feasibility and effectiveness are verified on simulated data.

Analysis of neutral beam driven impurity flow reversal in PLT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malik, M.A.; Stacey, W.M. Jr.; Thomas, C.E.

1986-10-01

The Stacey-Sigmar impurity transport theory for tokamak plasmas is applied to the analysis of experimental data from the PLT tokamak with a tungsten limiter. The drag term, which is a central piece in the theory, is evaluated from the recently developed gyroviscous theory for radial momentum transfer. An effort is made to base the modeling of the experiment on measured quantities. Where measured data is not available, recourse is made to extrapolation or numerical modeling. The theoretical and the experimental tungsten fluxes are shown to agree very closely within the uncertainties of the experimental data.

Nonlinear single-spin spectrum analyzer.

PubMed

Kotler, Shlomi; Akerman, Nitzan; Glickman, Yinnon; Ozeri, Roee

2013-03-15

Qubits have been used as linear spectrum analyzers of their environments. Here we solve the problem of nonlinear spectral analysis, required for discrete noise induced by a strongly coupled environment. Our nonperturbative analytical model shows a nonlinear signal dependence on noise power, resulting in a spectral resolution beyond the Fourier limit as well as frequency mixing. We develop a noise characterization scheme adapted to this nonlinearity. We then apply it using a single trapped ion as a sensitive probe of strong, non-Gaussian, discrete magnetic field noise. Finally, we experimentally compared the performance of equidistant vs Uhrig modulation schemes for spectral analysis.

Liquid chromatographic separation of zalcitabine and its stereoisomers.

PubMed

Scypinski, S; Ross, A J

1994-10-01

A liquid chromatographic method capable of separating and quantitating the stereoisomers of zalcitabine has been developed and validated. The separation was achieved with an Astec Cyclobond I--RSP column and a mobile phase of 0.25% triethylamine in water adjusted to a pH of 6.5 with glacial acetic acid. All enantiomers were found to exhibit a linear response in the range of 0.1-10% in the presence of 100% zalcitabine. Precision of analysis was found to be less than 1.5% at a level of 1% relative to zalcitabine. The limit of detection for two of the three enantiomeric impurities was determined to be 0.05% relative to zalcitabine. The detection limit for the third was found to be 0.1%. This method was successfully applied to the analysis of reference standards and several production scale batches. All of these materials were found to be stereochemically pure to a level of 99.8% or better.

Development of capillary electrophoresis methods for quantitative determination of taurine in vehicle system and biological media.

PubMed

da Silva, Dayse L P; Rüttinger, Hans H; Mrestani, Yahia; Baum, Walter F; Neubert, Reinhard H H

2006-06-01

CE methods have been developed for the determination of taurine in pharmaceutical formulation (microemulsion) and in biological media such as sweat. The CE system with end-column pulsed amperometric detection has been found to be an interesting method in comparison with UV and fluorescence detection for its simplicity and rapidity. A gold-disk electrode of 100 mm diameter was used as the working electrode. The effects of a field decoupler at the end of the capillary, separation voltage, injection and pressure times were investigated. A detection limit of 4 x 10(-5) mol/L was reached using integrated pulsed amperometric detection, a method successfully applied to taurine analysis of the biological samples such as sweat. For taurine analysis of oil-in-water microemulsion, fluorescence detector was the favored method, the detection limit of which was 4 x 10(-11) mol/L.

Validation of Ion Chromatographic Method for Determination of Standard Inorganic Anions in Treated and Untreated Drinking Water

NASA Astrophysics Data System (ADS)

Ivanova, V.; Surleva, A.; Koleva, B.

2018-06-01

An ion chromatographic method for determination of fluoride, chloride, nitrate and sulphate in untreated and treated drinking waters was described. An automated 850 IC Professional, Metrohm system equipped with conductivity detector and Metrosep A Supp 7-250 (250 x 4 mm) column was used. The validation of the method was performed for simultaneous determination of all studied analytes and the results have showed that the validated method fits the requirements of the current water legislation. The main analytical characteristics were estimated for each of studied analytes: limits of detection, limits of quantification, working and linear ranges, repeatability and intermediate precision, recovery. The trueness of the method was estimated by analysis of certified reference material for soft drinking water. Recovery test was performed on spiked drinking water samples. An uncertainty was estimated. The method was applied for analysis of drinking waters before and after chlorination.

Development of user-friendly and interactive data collection system for cerebral palsy.

PubMed

Raharjo, I; Burns, T G; Venugopalan, J; Wang, M D

2016-02-01

Cerebral palsy (CP) is a permanent motor disorder that appears in early age and it requires multiple tests to assess the physical and mental capabilities of the patients. Current medical record data collection systems, e.g., EPIC, employed for CP are very general, difficult to navigate, and prone to errors. The data cannot easily be extracted which limits data analysis on this rich source of information. To overcome these limitations, we designed and prototyped a database with a graphical user interface geared towards clinical research specifically in CP. The platform with MySQL and Java framework is reliable, secure, and can be easily integrated with other programming languages for data analysis such as MATLAB. This database with GUI design is a promising tool for data collection and can be applied in many different fields aside from CP to infer useful information out of the vast amount of data being collected.

Development of user-friendly and interactive data collection system for cerebral palsy

PubMed Central

Raharjo, I.; Burns, T. G.; Venugopalan, J.; Wang., M. D.

2016-01-01

Cerebral palsy (CP) is a permanent motor disorder that appears in early age and it requires multiple tests to assess the physical and mental capabilities of the patients. Current medical record data collection systems, e.g., EPIC, employed for CP are very general, difficult to navigate, and prone to errors. The data cannot easily be extracted which limits data analysis on this rich source of information. To overcome these limitations, we designed and prototyped a database with a graphical user interface geared towards clinical research specifically in CP. The platform with MySQL and Java framework is reliable, secure, and can be easily integrated with other programming languages for data analysis such as MATLAB. This database with GUI design is a promising tool for data collection and can be applied in many different fields aside from CP to infer useful information out of the vast amount of data being collected. PMID:28133638

Charge-transfer mechanisms for high-T/sub c/ superconductivity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jarrell, M.; Krishnamurthy, H.R.; Cox, D.L.

1988-09-01

We report results from a Bardeen-Cooper-Schrieffer (BCS) analysis of the Weber d-d exciton model of the high-temperature superconductors. The pairing between oxygen holes is mediated by localized intrasite charge-transfer excitations between the d/sub x//sub <2/-y/sup =/ and the d/sub 3//sub z//sub <2/-r/sup =/ Cu orbitals. For reasonable oxygen on-site Coulomb energies, we find s-wave superconductivity for low filling fraction (<0.44), and d-wave superconductivity for larger filling. The same symmetry analysis applies to a localized version of the intersite Cu-O charge-transfer model of Varma, Schmitt-Rink, and Abrahams. We explore the limitations imposed by the Weber model symmetry, and interpret optical datamore » based upon the d-d exciton picture. We briefly discuss the suppression of antiferromagnetism of the Cu moments by the Ruderman-Kittel-Kasuya-Yoshida interaction in the metallic limit.« less

Instruments used to assess functional limitations in workers applying for disability benefit: a systematic review.

PubMed

Spanjer, Jerry; Groothoff, Johan W; Brouwer, Sandra

2011-01-01

To systematically review the quality of the psychometric properties of instruments for assessing functional limitations in workers applying for disability benefit. Electronic searches of Medline, Embase, CINAHL and PsycINFO were performed to identify studies focusing on the psychometric properties of instruments used to assess functional limitations in workers' compensation claimants. Two independent reviewers applied the inclusion criteria to select relevant articles and then evaluated the psychometric qualities of the instruments found. Of the 712 articles that were identified, 10 studies met the inclusion criteria, reporting on four instruments: the Roland-Morris Disability Questionnaire (RMDQ), the Patient-Specific Functional Scale (PSFS), the Isernhagen Work System (IWS) and the Multiperspective Multidimensional Pain Assessment Protocol (MMPAP). The questionnaires (RMDQ and PSFS) did not focus specifically on the work situation and measured three to eight functional limitations. The psychometric qualities of the IWS were poor to moderate. For the MMPAP, only predictive validity was measured. The instruments assessed a range varying between 3 and 34 physical functional limitations. No instruments were found for assessing mental limitations in workers' compensation claimants. Studies on four instruments specifically focusing on assessing physical functional limitations in workers applying for disability benefit were found. All four instruments have limitations regarding their psychometric qualities or contents. Since the RMDQ has the best demonstrated psychometric qualities and takes little time to complete it, we recommend the RMDQ for clinicians in rehabilitation. For the assessment of functional limitations in workers applying for disability benefit a combination of questionnaires, performance tests or interviews together with the judgment by physicians looks the most promising.

Geometrically Nonlinear Finite Element Analysis of a Composite Space Reflector

NASA Technical Reports Server (NTRS)

Lee, Kee-Joo; Leet, Sung W.; Clark, Greg; Broduer, Steve (Technical Monitor)

2001-01-01

Lightweight aerospace structures, such as low areal density composite space reflectors, are highly flexible and may undergo large deflection under applied loading, especially during the launch phase. Accordingly, geometrically nonlinear analysis that takes into account the effect of finite rotation may be needed to determine the deformed shape for a clearance check and the stress and strain state to ensure structural integrity. In this study, deformation of the space reflector is determined under static conditions using a geometrically nonlinear solid shell finite element model. For the solid shell element formulation, the kinematics of deformation is described by six variables that are purely vector components. Because rotational angles are not used, this approach is free of the limitations of small angle increments. This also allows easy connections between substructures and large load increments with respect to the conventional shell formulation using rotational parameters. Geometrically nonlinear analyses were carried out for three cases of static point loads applied at selected points. A chart shows results for a case when the load is applied at the center point of the reflector dish. The computed results capture the nonlinear behavior of the composite reflector as the applied load increases. Also, they are in good agreement with the data obtained by experiments.

BMDExpress Data Viewer: A Visualization Tool to Analyze ...

EPA Pesticide Factsheets

Regulatory agencies increasingly apply benchmark dose (BMD) modeling to determine points of departure in human risk assessments. BMDExpress applies BMD modeling to transcriptomics datasets and groups genes to biological processes and pathways for rapid assessment of doses at which biological perturbations occur. However, graphing and analytical capabilities within BMDExpress are limited, and the analysis of output files is challenging. We developed a web-based application, BMDExpress Data Viewer, for visualization and graphical analyses of BMDExpress output files. The software application consists of two main components: ‘Summary Visualization Tools’ and ‘Dataset Exploratory Tools’. We demonstrate through two case studies that the ‘Summary Visualization Tools’ can be used to examine and assess the distributions of probe and pathway BMD outputs, as well as derive a potential regulatory BMD through the modes or means of the distributions. The ‘Functional Enrichment Analysis’ tool presents biological processes in a two-dimensional bubble chart view. By applying filters of pathway enrichment p-value and minimum number of significant genes, we showed that the Functional Enrichment Analysis tool can be applied to select pathways that are potentially sensitive to chemical perturbations. The ‘Multiple Dataset Comparison’ tool enables comparison of BMDs across multiple experiments (e.g., across time points, tissues, or organisms, etc.). The ‘BMDL-BM

[Perspective of intensive care nursing staff on the limitation of life support treatment].

PubMed

Vallès-Fructuoso, O; Ruiz-de Pablo, B; Fernández-Plaza, M; Fuentes-Milà, V; Vallès-Fructuoso, O; Martínez-Estalella, G

To determine the perspective of intensive care nursing staff on the limitation of life support treatment (LLST) in the Intensive Care Units. An exploratory qualitative study was carried out by applying the theory of Strauss and Corbin as the analysis tool. Constructivist paradigm. Nursing staff from three Intensive Care Units of Hospital Universitari de Bellvitge. Convenience sampling to reach theoretical saturation of data. Data collection through semi-structured interview recorded prior to informed consent. Rigor and quality criteria (reliability, credibility, transferability), and authenticity criteria: reflexivity. Demographic data was analysed using Excel. A total of 28 interviews were conducted. The mean age of the nurses was 35.6 years, with a mean seniority of 11.46 years of working in ICU. A minority of nurses (21.46%) had received basic training in bioethics. The large majority (85.7%) believe that LLST is not a common practice due to therapeutic cruelty and poor management with it. There is a correlation with the technical concepts; but among the main ethical problems is the decision to apply LLST. Nurses recognise that the decision on applying LLST depends on medical consensus with relatives, and they believe that their opinion is not considered. Their objective is trying to avoid suffering, and assist in providing a dignified death and support to relatives. There is still a paternalistic pattern between the doctor and patient relationship, where the doctor makes the decision and then agrees with the relatives to apply LLST. Organ failure and poor prognosis are the most important criteria for applying LLST. It is necessary to develop a guide for applying LLST, emphasising the involvement of nurses, patients, and their relatives. Copyright © 2016 Elsevier España, S.L.U. y SEEIUC. All rights reserved.

Semantic Annotation of Complex Text Structures in Problem Reports

NASA Technical Reports Server (NTRS)

Malin, Jane T.; Throop, David R.; Fleming, Land D.

2011-01-01

Text analysis is important for effective information retrieval from databases where the critical information is embedded in text fields. Aerospace safety depends on effective retrieval of relevant and related problem reports for the purpose of trend analysis. The complex text syntax in problem descriptions has limited statistical text mining of problem reports. The presentation describes an intelligent tagging approach that applies syntactic and then semantic analysis to overcome this problem. The tags identify types of problems and equipment that are embedded in the text descriptions. The power of these tags is illustrated in a faceted searching and browsing interface for problem report trending that combines automatically generated tags with database code fields and temporal information.

BIDS apps: Improving ease of use, accessibility, and reproducibility of neuroimaging data analysis methods

PubMed Central

Auer, Tibor; Churchill, Nathan W.; Flandin, Guillaume; Guntupalli, J. Swaroop; Raffelt, David; Quirion, Pierre-Olivier; Smith, Robert E.; Strother, Stephen C.; Varoquaux, Gaël

2017-01-01

The rate of progress in human neurosciences is limited by the inability to easily apply a wide range of analysis methods to the plethora of different datasets acquired in labs around the world. In this work, we introduce a framework for creating, testing, versioning and archiving portable applications for analyzing neuroimaging data organized and described in compliance with the Brain Imaging Data Structure (BIDS). The portability of these applications (BIDS Apps) is achieved by using container technologies that encapsulate all binary and other dependencies in one convenient package. BIDS Apps run on all three major operating systems with no need for complex setup and configuration and thanks to the comprehensiveness of the BIDS standard they require little manual user input. Previous containerized data processing solutions were limited to single user environments and not compatible with most multi-tenant High Performance Computing systems. BIDS Apps overcome this limitation by taking advantage of the Singularity container technology. As a proof of concept, this work is accompanied by 22 ready to use BIDS Apps, packaging a diverse set of commonly used neuroimaging algorithms. PMID:28278228

A liquid chromatography-mass spectrometric method for the determination of oak moss allergens atranol and chloroatranol in perfumes.

PubMed

Bossi, Rossana; Rastogi, Suresh C; Bernard, Guillaume; Gimenez-Arnau, Elena; Johansen, Jeanne D; Lepoittevin, Jean-Pierre; Menné, Torkil

2004-05-01

This paper describes a validated liquid chromatographic-tandem mass spectrometric method for quantitative analysis of the potential oak moss allergens atranol and chloroatranol in perfumes and similar products. The method employs LC-MS-MS with electrospray ionization (ESI) in negative mode. The compounds are analysed by selective reaction monitoring (SRM) of 2 or 3 ions for each compound in order to obtain high selectivity and sensitivity. The method has been validated for the following parameters: linearity; repeatability; recovery; limit of detection; and limit of quantification. The limits of detection, 5.0 ng/mL and 2.4 ng/mL, respectively, for atranol and chloroatranol, achieved by this method allowed identification of these compounds at concentrations below those causing allergic skin reactions in oak-moss-sensitive patients. The recovery of chloratranol from spiked perfumes was 96+/-4%. Low recoveries (49+/-5%) were observed for atranol in spiked perfumes, indicating ion suppression caused by matrix components. The method has been applied to the analysis of 10 randomly selected perfumes and similar products.

A rapid fluorescence assay for danofloxacin in beef muscle: effect of muscle type on limit of quantitation.

PubMed

Schneider, Marilyn J

2008-08-01

A simple, rapid fluorescence screening assay was applied to the analysis of beef muscle for danofloxacin at the U.S. tolerance level of 200 ng/g. Muscle samples were homogenized in acetic acid-acetonitrile, the resultant mixture centrifuged, and fluorescence of the supernatants was then measured. The significant difference between the fluorescence of control muscle sample extracts and extracts of samples fortified at 200 ng/g allowed for successful discrimination between the samples. Setting a threshold level at the average 200 ng/g fortified sample extract fluorescence -3sigma allowed for identification of potentially violative samples. Successful analysis of a group of blind fortified samples over a range of concentrations was accomplished in this manner, without any false-negative results. The limits of quantitation for danofloxacin, as well as enrofloxacin, using this assay were determined in three types of beef muscle (hanging tenderloin, neck, and eye round steak), as well as in serum. Significant differences in limits of quantitation were found among the three different muscle types examined, with hanging tenderloin muscle providing the lowest value. This work not only shows the potential for use of the fluorescence screening assay as an alternative to currently used microbial or antibody-based assays for the analysis of danofloxacin in beef muscle, but also suggests that assays using beef muscle may vary in performance depending on the specific muscle selected for analysis.

2016 Summer Series - Ophir Frieder - Searching Harsh Environments

NASA Image and Video Library

2016-07-12

Analysis of selective data that fits our investigative tool may lead to erroneous or limited conclusions. The universe consists of multi states and our recording of them adds complexity. By finding methods to increase the robustness of our digital data collection and applying likely relationship search methods that can handle all the data, we will increase the resolution of our conclusions. Frieder will present methods to increase our ability to capture and search digital data.

Quantitative Infrared Spectroscopy in Challenging Environments: Applications to Passive Remote Sensing and Process Monitoring

DTIC Science & Technology

2012-12-01

IR remote sensing o ers a measurement method to detect gaseous species in the outdoor environment. Two major obstacles limit the application of this... method in quantitative analysis : (1) the e ect of both temperature and concentration on the measured spectral intensities and (2) the di culty and...crucial. In this research, particle swarm optimization, a population- based optimization method was applied. Digital ltering and wavelet processing methods

Structure Limits for a 30mm Annular Piston.

DTIC Science & Technology

1988-05-01

block at the rear, ending the cycle. III. STRESS ANALYSIS PROCEDURE tress data was generated using the SAAS -II finite element computer code. Applied...Plastics Avenue Rockford, IL 61125 Pittsfield, MA 01201-3698 1 Veritay Technology, Inc. 1 General Electric Company ATTN: E.B. Fisher Armament Systems... VALUATION Slit:ET/CHANGE 01- ADDRESS -hi s laboratoryN undertakes a continuing effort to improve the quality of the( re-ports it publishe,4. Yfour comments

Investigation of High-Angle-of-Attack Maneuver-Limiting Factors. Part 1. Analysis and Simulation

DTIC Science & Technology

1980-12-01

useful, are not so satisfying or in- structive as the more positive identification of causal factors offered by the methods developed in Reference 5...same methods be applied to additional high-performance fighter aircraft having widely differing high AOA handling characteristics to see if further...predictions and the nonlinear model results were resolved. The second task involved development of methods , criteria, and an associated pilot rating scale, for

36 CFR § 1254.82 - What limitations apply to my use of self-service card-operated copiers?

Code of Federal Regulations, 2013 CFR

2013-07-01

... limitations apply to my use of self-service card-operated copiers? (a) There is a 5-minute time limit on..., we may limit you to three copies when others are waiting to use the machine. If you wish to copy... for an extended time period. (b) If we must cancel an appointment due to copier failure, we make every...

Multiresidue analysis of 22 sulfonamides and their metabolites in animal tissues using quick, easy, cheap, effective, rugged, and safe extraction and high resolution mass spectrometry (hybrid linear ion trap-Orbitrap).

PubMed

Abdallah, H; Arnaudguilhem, C; Jaber, F; Lobinski, R

2014-08-15

A new high performance liquid chromatography-high resolution mass spectrometry (HPLC-HRMS) method was developed for a simultaneous multi-residue analysis of 22 sulfonamides (SAs) and their metabolites in edible animal (pig, beef, sheep and chicken) tissues. Sample preparation was optimized on the basis of the "QuEChERS" protocol. The analytes were identified using their LC retention times and accurate mass; the identification was further confirmed by multi-stage high mass accuracy (<5ppm) mass spectrometry. The performance of the method was evaluated according to the EU guidelines for the validation of screening methods for the analysis of veterinary drugs residues. Acceptable values were obtained for: linearity (R(2)<0.99), limit of detection (LOD, 3-26μg/kg), limit of quantification (LOQ, 11-88μg/kg), accuracy (recovery 88-112%), intra- and inter-day precision 1-14 and 1-17%, respectively, decision limit (CCα) and detection capability (CCβ) around the maximum residue limits (MRL) of SAs (100μg/kg). The method was validated by analysis of a reference material FAPAS-02188 "Pig kidney" with ǀ Z-scoreǀ<0.63. The method was applied to various matrices (kidney, liver, muscle) originated from pig, beef, sheep, and chicken) allowing the simultaneous quantification of target sulfonamides at concentration levels above the MRL/2 and the identification of untargeted compounds such as N(4)-acetyl metabolites using multi-stage high mass accuracy mass spectrometry. Copyright © 2014 Elsevier B.V. All rights reserved.

Food Composition Database Format and Structure: A User Focused Approach

PubMed Central

Clancy, Annabel K.; Woods, Kaitlyn; McMahon, Anne; Probst, Yasmine

2015-01-01

This study aimed to investigate the needs of Australian food composition database user’s regarding database format and relate this to the format of databases available globally. Three semi structured synchronous online focus groups (M = 3, F = 11) and n = 6 female key informant interviews were recorded. Beliefs surrounding the use, training, understanding, benefits and limitations of food composition data and databases were explored. Verbatim transcriptions underwent preliminary coding followed by thematic analysis with NVivo qualitative analysis software to extract the final themes. Schematic analysis was applied to the final themes related to database format. Desktop analysis also examined the format of six key globally available databases. 24 dominant themes were established, of which five related to format; database use, food classification, framework, accessibility and availability, and data derivation. Desktop analysis revealed that food classification systems varied considerably between databases. Microsoft Excel was a common file format used in all databases, and available software varied between countries. User’s also recognised that food composition databases format should ideally be designed specifically for the intended use, have a user-friendly food classification system, incorporate accurate data with clear explanation of data derivation and feature user input. However, such databases are limited by data availability and resources. Further exploration of data sharing options should be considered. Furthermore, user’s understanding of food composition data and databases limitations is inherent to the correct application of non-specific databases. Therefore, further exploration of user FCDB training should also be considered. PMID:26554836

Fiber type-specific analysis of AMPK isoforms in human skeletal muscle: advancement in methods via capillary nanoimmunoassay.

PubMed

Tobias, Irene S; Lazauskas, Kara K; Arevalo, Jose A; Bagley, James R; Brown, Lee E; Galpin, Andrew J

2018-04-01

Human skeletal muscle is a heterogeneous mixture of multiple fiber types (FT). Unfortunately, present methods for FT-specific study are constrained by limits of protein detection in single-fiber samples. These limitations beget compensatory resource-intensive procedures, ultimately dissuading investigators from pursuing FT-specific research. Additionally, previous studies neglected hybrid FT, confining their analyses to only pure FT. Here we present novel methods of protein detection across a wider spectrum of human skeletal muscle FT using fully automated capillary nanoimmunoassay (CNIA) technology. CNIA allowed a ~20-fold-lower limit of 5'-AMP-activated protein kinase (AMPK) detection compared with Western blotting. We then performed FT-specific assessment of AMPK expression as a proof of concept. Individual human muscle fibers were mechanically isolated, dissolved, and myosin heavy chain (MHC) fiber typed via SDS-PAGE. Single-fiber samples were combined in pairs and grouped into MHC I, MHC I/IIa, MHC IIa, and MHC IIa/IIx for expression analysis of AMPK isoforms α 1 , α 2 , β 1 , β 2 , γ 2 , and γ 3 with a tubulin loading control. Significant FT-specific differences were found for α 2 (1.7-fold higher in MHC IIa and MHC IIa/IIx vs. others), γ 2 (2.5-fold higher in MHC IIa vs. others), and γ 3 (2-fold higher in MHC IIa and 4-fold higher in MHC IIa/IIx vs. others). Development of a protocol that combines the efficient and sensitive CNIA technology with comprehensive SDS-PAGE fiber typing marks an important advancement in FT-specific research because it allows more precise study of the molecular mechanisms governing metabolism, adaptation, and regulation in human muscle. NEW & NOTEWORTHY We demonstrate the viability of applying capillary nanoimmunoassay technology to the study of fiber type-specific protein analysis in human muscle fibers. This novel technique enables a ~20-fold-lower limit of protein detection compared with traditional Western blotting methods. Combined with SDS-PAGE methods of fiber typing, we apply this technique to compare 5'-AMP-activated protein kinase isoform expression in myosin heavy chain (MHC) I, MHC I/IIa, MHC IIa, and MHC IIa/IIx fiber types.

Enhanced low-template DNA analysis conditions and investigation of allele dropout patterns.

PubMed

Hedell, Ronny; Dufva, Charlotte; Ansell, Ricky; Mostad, Petter; Hedman, Johannes

2015-01-01

Forensic DNA analysis applying PCR enables profiling of minute biological samples. Enhanced analysis conditions can be applied to further push the limit of detection, coming with the risk of visualising artefacts and allele imbalances. We have evaluated the consecutive increase of PCR cycles from 30 to 35 to investigate the limitations of low-template (LT) DNA analysis, applying the short tandem repeat (STR) analysis kit PowerPlex ESX 16. Mock crime scene DNA extracts of four different quantities (from around 8-84 pg) were tested. All PCR products were analysed using 5, 10 and 20 capillary electrophoresis (CE) injection seconds. Bayesian models describing allele dropout patterns, allele peak heights and heterozygote balance were developed to assess the overall improvements in EPG quality with altered PCR/CE settings. The models were also used to evaluate the impact of amplicon length, STR marker and fluorescent label on the risk for allele dropout. The allele dropout probability decreased for each PCR cycle increment from 30 to 33 PCR cycles. Irrespective of DNA amount, the dropout probability was not affected by further increasing the number of PCR cycles. For the 42 and 84 pg samples, mainly complete DNA profiles were generated applying 32 PCR cycles. For the 8 and 17 pg samples, the allele dropouts decreased from 100% using 30 cycles to about 75% and 20%, respectively. The results for 33, 34 and 35 PCR cycles indicated that heterozygote balance and stutter ratio were mainly affected by DNA amount, and not directly by PCR cycle number and CE injection settings. We found 32 and 33 PCR cycles with 10 CE injection seconds to be optimal, as 34 and 35 PCR cycles did not improve allele detection and also included CE saturation problems. We find allele dropout probability differences between several STR markers. Markers labelled with the fluorescent dyes CXR-ET (red in electropherogram) and TMR-ET (shown as black) generally have higher dropout risks compared with those labelled with JOE (green) and fluorescein (blue). Overall, the marker D10S1248 has the lowest allele dropout probability and D8S1179 the highest. The marker effect is mainly pronounced for 30-32 PCR cycles. Such effects would not be expected if the amplification efficiencies were identical for all markers. Understanding allele dropout risks and the variability in peak heights and balances is important for correct interpretation of forensic DNA profiles. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

76 FR 20780 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

... volatility, if adopted, applies. The text of the proposed rule change is below. Proposed new language is... which a limit up/limit down mechanism to address extraordinary market volatility, if adopted, applies... market volatility, if adopted, applies [April 11, 2011], the prior versions of paragraphs (C), (c)(1...

Functions of behavior change interventions when implementing multi-professional teamwork at an emergency department: a comparative case study

PubMed Central

2014-01-01

Background While there is strong support for the benefits of working in multi-professional teams in health care, the implementation of multi-professional teamwork is reported to be complex and challenging. Implementation strategies combining multiple behavior change interventions are recommended, but the understanding of how and why the behavior change interventions influence staff behavior is limited. There is a lack of studies focusing on the functions of different behavior change interventions and the mechanisms driving behavior change. In this study, applied behavior analysis is used to analyze the function and impact of different behavior change interventions when implementing multi-professional teamwork. Methods A comparative case study design was applied. Two sections of an emergency department implemented multi-professional teamwork involving changes in work processes, aimed at increasing inter-professional collaboration. Behavior change interventions and staff behavior change were studied using observations, interviews and document analysis. Using a hybrid thematic analysis, the behavior change interventions were categorized according to the DCOM® model. The functions of the behavior change interventions were then analyzed using applied behavior analysis. Results The two sections used different behavior change interventions, resulting in a large difference in the degree of staff behavior change. The successful section enabled staff performance of teamwork behaviors with a strategy based on ongoing problem-solving and frequent clarification of directions. Managerial feedback initially played an important role in motivating teamwork behaviors. Gradually, as staff started to experience positive outcomes of the intervention, motivation for teamwork behaviors was replaced by positive task-generated feedback. Conclusions The functional perspective of applied behavior analysis offers insight into the behavioral mechanisms that describe how and why behavior change interventions influence staff behavior. The analysis demonstrates how enabling behavior change interventions, managerial feedback and task-related feedback interact in their influence on behavior and have complementary functions during different stages of implementation. PMID:24885212

Functional swallowing outcomes following treatment for oropharyngeal carcinoma: a systematic review of the evidence comparing trans-oral surgery versus non-surgical management.

PubMed

Dawe, N; Patterson, J; O'Hara, J

2016-08-01

Trans-oral surgical and non-surgical management options for oropharyngeal squamous cell carcinoma (OPSCC) appear to offer similar survival outcomes. Functional outcomes, in particular swallowing, have become of increasing interest in the debate regarding treatment options. Contemporary reviews on function following treatment frequently include surrogate markers and limit the value of comparative analysis. A systematic review was performed to establish whether direct comparisons of swallowing outcomes could be made between trans-oral surgical approaches (trans-oral laser microsurgery (TLM)/trans-oral robotic surgery (TORS)) and (chemo)radiotherapy ((C)RT). Systematic review. MEDLINE, Embase and Cochrane databases were interrogated using the following MeSH terms: antineoplastic protocols, chemotherapy, radiotherapy, deglutition disorders, swallowing, lasers, and trans-oral surgery. Two authors performed independent systematic reviews and consensus was sought if opinions differed. The WHO ICF classification was applied to generate analysis based around body functions and structure, activity limitations and participation restriction. Thirty-seven citations were included in the analysis. Twenty-six papers reported the outcomes for OPSCC treatment following primary (C)RT in 1377 patients, and 15 papers following contemporary trans-oral approaches in 768 patients. Meta-analysis was not feasible due to varying methodology and heterogeneity of outcome measures. Instrumental swallowing assessments were presented in 13/26 (C)RT versus 2/15 TLM/TORS papers. However, reporting methods of these studies were not standardised. This variety of outcome measures and the wide-ranging intentions of authors applying the measures in individual studies limit any practical direct comparisons of the effects of treatment on swallowing outcomes between interventions. From the current evidence, no direct comparisons could be made of swallowing outcomes between the surgical and non-surgical modalities. Swallowing is a multidimensional construct, and the range of assessments utilised by authors reflects the variety of available reporting methods. The MD Anderson Dysphagia Inventory is a subjective measure that allows limited comparison between the currently available heterogeneous data, and is explored in detail. The findings highlight that further research may identify the most appropriate tools for measuring swallowing in patients with OPSCC. Consensus should allow their standardised integration into future studies and randomised control trials. © 2015 John Wiley & Sons Ltd.

Efficient runner safety assessment during early design phase and root cause analysis

NASA Astrophysics Data System (ADS)

Liang, Q. W.; Lais, S.; Gentner, C.; Braun, O.

2012-11-01

Fatigue related problems in Francis turbines, especially high head Francis turbines, have been published several times in the last years. During operation the runner is exposed to various steady and unsteady hydraulic loads. Therefore the analysis of forced response of the runner structure requires a combined approach of fluid dynamics and structural dynamics. Due to the high complexity of the phenomena and due to the limitation of computer power, the numerical prediction was in the past too expensive and not feasible for the use as standard design tool. However, due to continuous improvement of the knowledge and the simulation tools such complex analysis has become part of the design procedure in ANDRITZ HYDRO. This article describes the application of most advanced analysis techniques in runner safety check (RSC), including steady state CFD analysis, transient CFD analysis considering rotor stator interaction (RSI), static FE analysis and modal analysis in water considering the added mass effect, in the early design phase. This procedure allows a very efficient interaction between the hydraulic designer and the mechanical designer during the design phase, such that a risk of failure can be detected and avoided in an early design stage.The RSC procedure can also be applied to a root cause analysis (RCA) both to find out the cause of failure and to quickly define a technical solution to meet the safety criteria. An efficient application to a RCA of cracks in a Francis runner is quoted in this article as an example. The results of the RCA are presented together with an efficient and inexpensive solution whose effectiveness could be proven again by applying the described RSC technics. It is shown that, with the RSC procedure developed and applied as standard procedure in ANDRITZ HYDRO such a failure is excluded in an early design phase. Moreover, the RSC procedure is compatible with different commercial and open source codes and can be easily adapted to apply for other types of turbines, such as pump turbines and Pelton runners.

Enhanced compressed sensing for visual target tracking in wireless visual sensor networks

NASA Astrophysics Data System (ADS)

Qiang, Guo

2017-11-01

Moving object tracking in wireless sensor networks (WSNs) has been widely applied in various fields. Designing low-power WSNs for the limited resources of the sensor, such as energy limitation, energy restriction, and bandwidth constraints, is of high priority. However, most existing works focus on only single conflicting optimization criteria. An efficient compressive sensing technique based on a customized memory gradient pursuit algorithm with early termination in WSNs is presented, which strikes compelling trade-offs among energy dissipation for wireless transmission, certain types of bandwidth, and minimum storage. Then, the proposed approach adopts an unscented particle filter to predict the location of the target. The experimental results with a theoretical analysis demonstrate the substantially superior effectiveness of the proposed model and framework in regard to the energy and speed under the resource limitation of a visual sensor node.

Stringency of workplace air contaminant exposure limits: a case study of OSHA risk management.

PubMed

Hakes, J K

1999-12-01

Political context may play a large role in influencing the efficiency of environmental and health regulations. This case study uses data from a 1989 update of the Occupational Safety and Health Administration (OSHA) Permissible Exposure Limits (PELs) program to determine the relative effects of legislative mandates, costly acquisition of information by the agency, and pressure applied by special interest groups upon exposure standards. The empirical analysis suggests that federal agencies successfully thwart legislative attempts to limit agency discretion, and that agencies exercise bounded rationality by placing greater emphasis on more easily obtained information. The 1989 PELs were less significantly related to more costly information, contained "safety factors" for chemicals presenting relatively more ambiguous risks, and the proposed standard stringencies showed evidence of being influenced by vying industry and labor interests.

Precision of the calibration of the AXAF engineering test article (VETA) mirrors

NASA Technical Reports Server (NTRS)

Schwartz, D. A.; Chartas, G.; Hughes, John P.; Kellogg, Edwin M.; Zhao, Ping

1992-01-01

Measurements of the VETA encircled energies have been performed at 5 energies within 16 radii ranging from 0.05 to 200 arcseconds. We report here on the analysis of the accuracy of those measurements. A common 'error tree' structure applies, and we present representative numbers for the larger terms. At 0.277, 1.5, and 2.07 keV, and for radii of 3 arcsec and larger, our measurements have estimated 1 sigma errors of 0.6 to 1.5 percent. Effects of measurement statistics and of the VETA test mount limit the accuracy at smaller angles, and modulation by the counter window support structure together with the imperfect position repeatability limit the accuracy for the 0.93 and 2.3 keV energies. We expect to mitigate these limitations when calibrating the complete AXAF flight mirror assembly.

Precision of the calibration of the AXAF Engineering Test Article (VETA) mirrors

NASA Technical Reports Server (NTRS)

Schwartz, D. A.; Chartas, G.; Hughes, J. P.; Kellogg, E. M.; Zhao, Ping

1993-01-01

Measurements of the VETA encircled energies have been performed at 5 energies within 16 radii ranging from 0.05 to 200 arcseconds. We report here on the analysis of the accuracy of those measurements. A common 'error tree' structure applies, and we present representative numbers for the larger terms. At 0.277, 1.5, and 2.07 keV, and for radii of 3 arcsec and larger, our measurements have estimated 1 sigma errors of 0.6 to 1.5 percent. Effects of measurement statistics and of the VETA test mount limit the accuracy at smaller angles, and modulation by the counter window support structure together with the imperfect position repeatability limit the accuracy for the 0.93 and 2.3 keV energies. We expect to mitigate these limitations when calibrating the complete AXAF flight mirror assembly.

Analytical and CASE study on Limited Search, ID3, CHAID, C4.5, Improved C4.5 and OVA Decision Tree Algorithms to design Decision Support System

NASA Astrophysics Data System (ADS)

Kaur, Parneet; Singh, Sukhwinder; Garg, Sushil; Harmanpreet

2010-11-01

In this paper we study about classification algorithms for farm DSS. By applying classification algorithms i.e. Limited search, ID3, CHAID, C4.5, Improved C4.5 and One VS all Decision Tree on common data set of crop with specified class, results are obtained. The tool used to derive results is SPINA. The graphical results obtained from tool are compared to suggest best technique to develop farm Decision Support System. This analysis would help to researchers to design effective and fast DSS for farmer to take decision for enhancing their yield.

Current-limiting and ultrafast system for the characterization of resistive random access memories.

PubMed

Diaz-Fortuny, J; Maestro, M; Martin-Martinez, J; Crespo-Yepes, A; Rodriguez, R; Nafria, M; Aymerich, X

2016-06-01

A new system for the ultrafast characterization of resistive switching phenomenon is developed to acquire the current during the Set and Reset process in a microsecond time scale. A new electronic circuit has been developed as a part of the main setup system, which is capable of (i) applying a hardware current limit ranging from nanoampers up to miliampers and (ii) converting the Set and Reset exponential gate current range into an equivalent linear voltage. The complete system setup allows measuring with a microsecond resolution. Some examples demonstrate that, with the developed setup, an in-depth analysis of resistive switching phenomenon and random telegraph noise can be made.

Beam propagation factor based on the Rényi entropy.

PubMed

Vaveliuk, Pablo; da Silva, Marcone Lopes

2008-09-15

A beam width measure based on Rényi entropy was introduced by Luis [Opt. Lett 31, 3644 (2006)]. That one-dimensional analysis was limited to beam profiles with rectangular symmetry. In this Letter, we derive a general Rényi beam width measure that accounts for the diffraction properties of beams with profiles of arbitrary symmetry. We also show that the square of this measure has a quadratic dependence as a function of the propagation coordinate, so that it can be applied to propagation through arbitrary ABCD paraxial systems. The Rényi beam propagation factor, here introduced, is discussed in examples where the M(2) factor seems to have a limited effectiveness in describing the beam spreading.

Error analysis of motion correction method for laser scanning of moving objects

NASA Astrophysics Data System (ADS)

Goel, S.; Lohani, B.

2014-05-01

The limitation of conventional laser scanning methods is that the objects being scanned should be static. The need of scanning moving objects has resulted in the development of new methods capable of generating correct 3D geometry of moving objects. Limited literature is available showing development of very few methods capable of catering to the problem of object motion during scanning. All the existing methods utilize their own models or sensors. Any studies on error modelling or analysis of any of the motion correction methods are found to be lacking in literature. In this paper, we develop the error budget and present the analysis of one such `motion correction' method. This method assumes availability of position and orientation information of the moving object which in general can be obtained by installing a POS system on board or by use of some tracking devices. It then uses this information along with laser scanner data to apply correction to laser data, thus resulting in correct geometry despite the object being mobile during scanning. The major application of this method lie in the shipping industry to scan ships either moving or parked in the sea and to scan other objects like hot air balloons or aerostats. It is to be noted that the other methods of "motion correction" explained in literature can not be applied to scan the objects mentioned here making the chosen method quite unique. This paper presents some interesting insights in to the functioning of "motion correction" method as well as a detailed account of the behavior and variation of the error due to different sensor components alone and in combination with each other. The analysis can be used to obtain insights in to optimal utilization of available components for achieving the best results.

A Bayesian Framework for Analysis of Pseudo-Spatial Models of Comparable Engineered Systems with Application to Spacecraft Anomaly Prediction Based on Precedent Data

NASA Astrophysics Data System (ADS)

Ndu, Obibobi Kamtochukwu

To ensure that estimates of risk and reliability inform design and resource allocation decisions in the development of complex engineering systems, early engagement in the design life cycle is necessary. An unfortunate constraint on the accuracy of such estimates at this stage of concept development is the limited amount of high fidelity design and failure information available on the actual system under development. Applying the human ability to learn from experience and augment our state of knowledge to evolve better solutions mitigates this limitation. However, the challenge lies in formalizing a methodology that takes this highly abstract, but fundamentally human cognitive, ability and extending it to the field of risk analysis while maintaining the tenets of generalization, Bayesian inference, and probabilistic risk analysis. We introduce an integrated framework for inferring the reliability, or other probabilistic measures of interest, of a new system or a conceptual variant of an existing system. Abstractly, our framework is based on learning from the performance of precedent designs and then applying the acquired knowledge, appropriately adjusted based on degree of relevance, to the inference process. This dissertation presents a method for inferring properties of the conceptual variant using a pseudo-spatial model that describes the spatial configuration of the family of systems to which the concept belongs. Through non-metric multidimensional scaling, we formulate the pseudo-spatial model based on rank-ordered subjective expert perception of design similarity between systems that elucidate the psychological space of the family. By a novel extension of Kriging methods for analysis of geospatial data to our "pseudo-space of comparable engineered systems", we develop a Bayesian inference model that allows prediction of the probabilistic measure of interest.

Single-cell analysis of the transcriptome and its application in the characterization of stem cells and early embryos.

PubMed

Liu, Na; Liu, Lin; Pan, Xinghua

2014-07-01

Cellular heterogeneity within a cell population is a common phenomenon in multicellular organisms, tissues, cultured cells, and even FACS-sorted subpopulations. Important information may be masked if the cells are studied as a mass. Transcriptome profiling is a parameter that has been intensively studied, and relatively easier to address than protein composition. To understand the basis and importance of heterogeneity and stochastic aspects of the cell function and its mechanisms, it is essential to examine transcriptomes of a panel of single cells. High-throughput technologies, starting from microarrays and now RNA-seq, provide a full view of the expression of transcriptomes but are limited by the amount of RNA for analysis. Recently, several new approaches for amplification and sequencing the transcriptome of single cells or a limited low number of cells have been developed and applied. In this review, we summarize these major strategies, such as PCR-based methods, IVT-based methods, phi29-DNA polymerase-based methods, and several other methods, including their principles, characteristics, advantages, and limitations, with representative applications in cancer stem cells, early development, and embryonic stem cells. The prospects for development of future technology and application of transcriptome analysis in a single cell are also discussed.

Comparative Analysis of Disease-Linked Single Nucleotide Polymorphic Markers from Brassica rapa for Their Applicability to Brassica oleracea

PubMed Central

Cho, Young-Il; Ahn, Yul-Kyun; Tripathi, Swati; Kim, Jeong-Ho; Lee, Hye-Eun; Kim, Do-Sun

2015-01-01

Numerous studies using single nucleotide polymorphisms (SNPs) have been conducted in humans, and other animals, and in major crops, including rice, soybean, and Chinese cabbage. However, the number of SNP studies in cabbage is limited. In this present study, we evaluated whether 7,645 SNPs previously identified as molecular markers linked to disease resistance in the Brassica rapa genome could be applied to B. oleracea. In a BLAST analysis using the SNP sequences of B. rapa and B. oleracea genomic sequence data registered in the NCBI database, 256 genes for which SNPs had been identified in B. rapa were found in B. oleracea. These genes were classified into three functional groups: molecular function (64 genes), biological process (96 genes), and cellular component (96 genes). A total of 693 SNP markers, including 145 SNP markers [BRH—developed from the B. rapa genome for high-resolution melt (HRM) analysis], 425 SNP markers (BRP—based on the B. rapa genome that could be applied to B. oleracea), and 123 new SNP markers (BRS—derived from BRP and designed for HRM analysis), were investigated for their ability to amplify sequences from cabbage genomic DNA. In total, 425 of the SNP markers (BRP-based on B. rapa genome), selected from 7,645 SNPs, were successfully applied to B. oleracea. Using PCR, 108 of 145 BRH (74.5%), 415 of 425 BRP (97.6%), and 118 of 123 BRS (95.9%) showed amplification, suggesting that it is possible to apply SNP markers developed based on the B. rapa genome to B. oleracea. These results provide valuable information that can be utilized in cabbage genetics and breeding programs using molecular markers derived from other Brassica species. PMID:25790283

Design and Validation of In-Source Atmospheric Pressure Photoionization Hydrogen/Deuterium Exchange Mass Spectrometry with Continuous Feeding of D2O.

PubMed

Acter, Thamina; Lee, Seulgidaun; Cho, Eunji; Jung, Maeng-Joon; Kim, Sunghwan

2018-01-01

In this study, continuous in-source hydrogen/deuterium exchange (HDX) atmospheric pressure photoionization (APPI) mass spectrometry (MS) with continuous feeding of D 2 O was developed and validated. D 2 O was continuously fed using a capillary line placed on the center of a metal plate positioned between the UV lamp and nebulizer. The proposed system overcomes the limitations of previously reported APPI HDX-MS approaches where deuterated solvents were premixed with sample solutions before ionization. This is particularly important for APPI because solvent composition can greatly influence ionization efficiency as well as the solubility of analytes. The experimental parameters for APPI HDX-MS with continuous feeding of D 2 O were optimized, and the optimized conditions were applied for the analysis of nitrogen-, oxygen-, and sulfur-containing compounds. The developed method was also applied for the analysis of the polar fraction of a petroleum sample. Thus, the data presented in this study clearly show that the proposed HDX approach can serve as an effective analytical tool for the structural analysis of complex mixtures. Graphical abstract ᅟ.

Extractive Atmospheric Pressure Photoionization (EAPPI) Mass Spectrometry: Rapid Analysis of Chemicals in Complex Matrices.

PubMed

Liu, Chengyuan; Yang, Jiuzhong; Wang, Jian; Hu, Yonghua; Zhao, Wan; Zhou, Zhongyue; Qi, Fei; Pan, Yang

2016-10-01

Extractive atmospheric pressure photoionization (EAPPI) mass spectrometry was designed for rapid qualitative and quantitative analysis of chemicals in complex matrices. In this method, an ultrasonic nebulization system was applied to sample extraction, nebulization, and vaporization. Mixed with a gaseous dopant, vaporized analytes were ionized through ambient photon-induced ion-molecule reactions, and were mass-analyzed by a high resolution time-of-flight mass spectrometer (TOF-MS). After careful optimization and testing with pure sample solution, EAPPI was successfully applied to the fast screening of capsules, soil, natural products, and viscous compounds. Analysis was completed within a few seconds without the need for preseparation. Moreover, the quantification capability of EAPPI for matrices was evaluated by analyzing six polycyclic aromatic hydrocarbons (PAHs) in soil. The correlation coefficients (R (2) ) for standard curves of all six PAHs were above 0.99, and the detection limits were in the range of 0.16-0.34 ng/mg. In addition, EAPPI could also be used to monitor organic chemical reactions in real time. Graphical Abstract ᅟ.

Overlapping communities detection based on spectral analysis of line graphs

NASA Astrophysics Data System (ADS)

Gui, Chun; Zhang, Ruisheng; Hu, Rongjing; Huang, Guoming; Wei, Jiaxuan

2018-05-01

Community in networks are often overlapping where one vertex belongs to several clusters. Meanwhile, many networks show hierarchical structure such that community is recursively grouped into hierarchical organization. In order to obtain overlapping communities from a global hierarchy of vertices, a new algorithm (named SAoLG) is proposed to build the hierarchical organization along with detecting the overlap of community structure. SAoLG applies the spectral analysis into line graphs to unify the overlap and hierarchical structure of the communities. In order to avoid the limitation of absolute distance such as Euclidean distance, SAoLG employs Angular distance to compute the similarity between vertices. Furthermore, we make a micro-improvement partition density to evaluate the quality of community structure and use it to obtain the more reasonable and sensible community numbers. The proposed SAoLG algorithm achieves a balance between overlap and hierarchy by applying spectral analysis to edge community detection. The experimental results on one standard network and six real-world networks show that the SAoLG algorithm achieves higher modularity and reasonable community number values than those generated by Ahn's algorithm, the classical CPM and GN ones.

Joint Multi-Leaf Segmentation, Alignment, and Tracking for Fluorescence Plant Videos.

PubMed

Yin, Xi; Liu, Xiaoming; Chen, Jin; Kramer, David M

2018-06-01

This paper proposes a novel framework for fluorescence plant video processing. The plant research community is interested in the leaf-level photosynthetic analysis within a plant. A prerequisite for such analysis is to segment all leaves, estimate their structures, and track them over time. We identify this as a joint multi-leaf segmentation, alignment, and tracking problem. First, leaf segmentation and alignment are applied on the last frame of a plant video to find a number of well-aligned leaf candidates. Second, leaf tracking is applied on the remaining frames with leaf candidate transformation from the previous frame. We form two optimization problems with shared terms in their objective functions for leaf alignment and tracking respectively. A quantitative evaluation framework is formulated to evaluate the performance of our algorithm with four metrics. Two models are learned to predict the alignment accuracy and detect tracking failure respectively in order to provide guidance for subsequent plant biology analysis. The limitation of our algorithm is also studied. Experimental results show the effectiveness, efficiency, and robustness of the proposed method.

Incompressible boundary-layer stability analysis of LFC experimental data for sub-critical Mach numbers. M.S. Thesis

NASA Technical Reports Server (NTRS)

Berry, S. A.

1986-01-01

An incompressible boundary-layer stability analysis of Laminar Flow Control (LFC) experimental data was completed and the results are presented. This analysis was undertaken for three reasons: to study laminar boundary-layer stability on a modern swept LFC airfoil; to calculate incompressible design limits of linear stability theory as applied to a modern airfoil at high subsonic speeds; and to verify the use of linear stability theory as a design tool. The experimental data were taken from the slotted LFC experiment recently completed in the NASA Langley 8-Foot Transonic Pressure Tunnel. Linear stability theory was applied and the results were compared with transition data to arrive at correlated n-factors. Results of the analysis showed that for the configuration and cases studied, Tollmien-Schlichting (TS) amplification was the dominating disturbance influencing transition. For these cases, incompressible linear stability theory correlated with an n-factor for TS waves of approximately 10 at transition. The n-factor method correlated rather consistently to this value despite a number of non-ideal conditions which indicates the method is useful as a design tool for advanced laminar flow airfoils.

Use of multicriteria analysis (MCA) for sustainable hydropower planning and management.

PubMed

Vassoney, Erica; Mammoliti Mochet, Andrea; Comoglio, Claudio

2017-07-01

Multicriteria analysis (MCA) is a decision-making tool applied to a wide range of environmental management problems, including renewable energy planning and management. An interesting field of application of MCA is the evaluation and analysis of the conflicting aspects of hydropower (HP) exploitation, affecting the three pillars of sustainability and involving several different stakeholders. The present study was aimed at reviewing the state of the art of MCA applications to sustainable hydropower production and related decision-making problems, based on a detailed analysis of the scientific papers published over the last 15 years on this topic. The papers were analysed and compared, focusing on the specific features of the MCA methods applied in the described case studies, highlighting the general aspects of the MCA application (purpose, spatial scale, software used, stakeholders, etc.) and the specific operational/technical features of the selected MCA technique (methodology, criteria, evaluation, approach, sensitivity, etc.). Some specific limitations of the analysed case studies were identified and a set of "quality indexes" of an exhaustive MCA application were suggested as potential improvements for more effectively support decision-making processes in sustainable HP planning and management problems. Copyright © 2017 Elsevier Ltd. All rights reserved.

PFA toolbox: a MATLAB tool for Metabolic Flux Analysis.

PubMed

Morales, Yeimy; Bosque, Gabriel; Vehí, Josep; Picó, Jesús; Llaneras, Francisco

2016-07-11

Metabolic Flux Analysis (MFA) is a methodology that has been successfully applied to estimate metabolic fluxes in living cells. However, traditional frameworks based on this approach have some limitations, particularly when measurements are scarce and imprecise. This is very common in industrial environments. The PFA Toolbox can be used to face those scenarios. Here we present the PFA (Possibilistic Flux Analysis) Toolbox for MATLAB, which simplifies the use of Interval and Possibilistic Metabolic Flux Analysis. The main features of the PFA Toolbox are the following: (a) It provides reliable MFA estimations in scenarios where only a few fluxes can be measured or those available are imprecise. (b) It provides tools to easily plot the results as interval estimates or flux distributions. (c) It is composed of simple functions that MATLAB users can apply in flexible ways. (d) It includes a Graphical User Interface (GUI), which provides a visual representation of the measurements and their uncertainty. (e) It can use stoichiometric models in COBRA format. In addition, the PFA Toolbox includes a User's Guide with a thorough description of its functions and several examples. The PFA Toolbox for MATLAB is a freely available Toolbox that is able to perform Interval and Possibilistic MFA estimations.

A standards-based method for compositional analysis by energy dispersive X-ray spectrometry using multivariate statistical analysis: application to multicomponent alloys.

PubMed

Rathi, Monika; Ahrenkiel, S P; Carapella, J J; Wanlass, M W

2013-02-01

Given an unknown multicomponent alloy, and a set of standard compounds or alloys of known composition, can one improve upon popular standards-based methods for energy dispersive X-ray (EDX) spectrometry to quantify the elemental composition of the unknown specimen? A method is presented here for determining elemental composition of alloys using transmission electron microscopy-based EDX with appropriate standards. The method begins with a discrete set of related reference standards of known composition, applies multivariate statistical analysis to those spectra, and evaluates the compositions with a linear matrix algebra method to relate the spectra to elemental composition. By using associated standards, only limited assumptions about the physical origins of the EDX spectra are needed. Spectral absorption corrections can be performed by providing an estimate of the foil thickness of one or more reference standards. The technique was applied to III-V multicomponent alloy thin films: composition and foil thickness were determined for various III-V alloys. The results were then validated by comparing with X-ray diffraction and photoluminescence analysis, demonstrating accuracy of approximately 1% in atomic fraction.