7 CFR 250.16 - Maintenance of records.

Code of Federal Regulations, 2011 CFR

2011-01-01

... processor, food service management company, warehouse, or other entity which contracts with a distributing... the data and method used to determine the number of eligible persons served by that agency. (6... management company, warehouse or other entity to maintain records required by this Section shall be...

Pacific Region School Finance and Facilities Study.

ERIC Educational Resources Information Center

Kawakami, Alice J., Ed.

A study of school financing and facilities was conducted in the 10 American-affiliated Pacific entities of the United States. Data were collected from public departments of education in 9 of 10 entities served by the Pacific Region Educational Laboratory (PREL): American Samoa, Commonwealth of the Northern Mariana Islands (CNMI), Federated States…

77 FR 7133 - Advisory Committee on Supply Chain Competitiveness Solicitation of Nominations for Membership

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-10

... DEPARTMENT OF COMMERCE International Trade Administration Advisory Committee on Supply Chain... Organizations or Entities, Including Ports, To Apply for Membership on the Advisory Committee on Supply Chain... organizations or entities, including ports, to serve as members of the Advisory Committee on Supply Chain...

76 FR 27300 - Hazardous Materials: Cargo Tank Motor Vehicle Loading and Unloading Operations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

... Motor Vehicle Loading and Unloading Operations AGENCY: Pipeline and Hazardous Materials Safety... cargo tank motor vehicle proposals in this notice, we are providing affected entities as well as the...

Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity.

PubMed

Jadoon, Saima; Karim, Sabiha; Bin Asad, Muhammad Hassham Hassan; Akram, Muhammad Rouf; Khan, Abida Kalsoom; Malik, Arif; Chen, Chunye; Murtaza, Ghulam

2015-01-01

The exposure to ultraviolet radiations (UVR) is the key source of skin sunburn; it may produce harmful entities, reactive oxygen species (ROS), leading to aging. The skin can be treated and protected from the injurious effects of ROS by using various pharmaceutical formulations, such as cream. Cream can be loaded with antioxidants to quench ROS leading to photo-protective effects. Moreover, modern medicines depend on ethnobotanicals for protection or treatment of human diseases. This review article summarizes various in vivo antioxidant studies on herbal creams loaded with phyto-extracts. These formulations may serve as cosmeceuticals to protect skin against injurious effects of UVR. The botanicals studied for dermatologic use in cream form include Acacia nilotica, Benincasa hispida, Calendula officinalis, Camellia sinensis, Camellia sinensis, Nelumbo nucifera, Capparis decidua, Castanea sativa, Coffea arabica, Crocus sativus, Emblica officinalis Gaertn, Foeniculum vulgare, Hippophae rhamnoides, Lithospermum erythrorhizon, Malus domestica, Matricaria chamomilla L., Moringa oleifera, Morus alba, Ocimum basilicum, Oryza sativa, Polygonum minus, Punica granatum, Silybum marianum, Tagetes erecta Linn., Terminalia chebula, Trigonella foenum-graecum, and Vitis vinifera. The observed anti-aging effects of cream formulations could be an outcome of a coordinating action of multiple constituents. Of numerous botanicals, the phenolic acids and flavonoids appear effective against UVR-induced damage; however the evidence-based studies for their anti-aging effects are still needed.

20 CFR 662.210 - What other entities may serve as One-Stop partners?

Code of Federal Regulations, 2010 CFR

2010-04-01

...) WIA provides that other entities that carry out a human resource program, including Federal, State, or... partners? 662.210 Section 662.210 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF... Act (42 U.S.C. 601 et seq.); (2) Employment and training programs authorized under section 6(d)(4) of...

Improved Antitumor Efficacy and Pharmacokinetics of Bufalin via PEGylated Liposomes

NASA Astrophysics Data System (ADS)

Yuan, Jiani; Zhou, Xuanxuan; Cao, Wei; Bi, Linlin; Zhang, Yifang; Yang, Qian; Wang, Siwang

2017-11-01

Bufalin was reported to show strong pharmacological effects including cardiotonic, antiviral, immune-regulation, and especially antitumor effects. The objective of this study was to determine the characterization, antitumor efficacy, and pharmacokinetics of bufalin-loaded PEGylated liposomes compared with bufalin entity, which were prepared by FDA-approved pharmaceutical excipients. Bufalin-loaded PEGylated liposomes and bufalin-loaded liposomes were prepared reproducibly with homogeneous particle size by the combination of thin film evaporation method and high-pressure homogenization method. Their mean particle sizes were 127.6 and 155.0 nm, mean zeta potentials were 2.24 and - 18.5 mV, and entrapment efficiencies were 76.31 and 78.40%, respectively. In vitro release profile revealed that the release of bufalin in bufalin-loaded PEGylated liposomes was slower than that in bufalin-loaded liposomes. The cytotoxicity of blank liposomes has been found within acceptable range, whereas bufalin-loaded PEGylated liposomes showed enhanced cytotoxicity to U251 cells compared with bufalin entity. In vivo pharmacokinetics indicated that bufalin-loaded PEGylated liposomes could extend or eliminate the half-life time of bufalin in plasma in rats. The results suggested that bufalin-loaded PEGylated liposomes improved the solubility and increased the drug concentration in plasma.

A Randomized Response Model For Privacy Preserving Smart Metering.

PubMed

Wang, Shuang; Cui, Lijuan; Que, Jialan; Choi, Dae-Hyun; Jiang, Xiaoqian; Cheng, Samuel; Xie, Le

2012-09-01

The adoption of smart meters may bring new privacy concerns to the general public. Given the fact that metering data of individual homes/factories is accumulated every 15 minutes, it is possible to infer the pattern of electricity consumption of individual users. In order to protect the privacy of users in a completely de-centralized setting (i.e., individuals do not communicate with one another), we propose a novel protocol, which allows individual meters to report the true electricity consumption reading with a pre-determinted probability. Load serving entities (LSE) can reconstruct the total electricity consumption of a region or a district through inference algorithm, but their ability of identifying individual users' energy consumption pattern is significantly reduced. Using simulated data, we verify the feasibility of the proposed method and demonstrate performance advantages over existing approaches.

Pointing and Reference in Sign Language and Spoken Language: Anchoring vs. Identifying

ERIC Educational Resources Information Center

Barberà, Gemma; Zwets, Martine

2013-01-01

In both signed and spoken languages, pointing serves to direct an addressee's attention to a particular entity. This entity may be either present or absent in the physical context of the conversation. In this article we focus on pointing directed to nonspeaker/nonaddressee referents in Sign Language of the Netherlands (Nederlandse Gebarentaal,…

Business Entity Selection: Why It Matters to Healthcare Practitioners. Part II--Corporations, Limited Liability Companies, and Professional Entities.

PubMed

Nithman, Robert W

2015-01-01

The Bureau of Labor statistics indicates only a 50% four-year survivability rate among businesses classified as "education and health services." Gaining knowledge of IRS business entities can result in cost savings, operational efficiency, reduced liability, and enhanced sustainability. Each entity has unique disadvantages, depending on size, diversity of ownership, desire to expand, and profitability. Business structures should be compatible with organizational mission or vision statements, services and products, and professional codes of ethics. Healthcare reform will require greater business acumen. We have an ethical duty to disseminate and acquire the knowledge to properly establish and manage healthcare practices to ensure sustainable services that protect and serve the community.

Synthetic Approaches to the New Drugs Approved During 2015.

PubMed

Flick, Andrew C; Ding, Hong X; Leverett, Carolyn A; Kyne, Robert E; Liu, Kevin K-C; Fink, Sarah J; O'Donnell, Christopher J

2017-08-10

New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide insight into molecular recognition while serving as leads for designing future new drugs. This annual review describes the most likely process-scale synthetic approaches to 29 new chemical entities (NCEs) that were approved for the first time in 2015.

Identifying Liver Cancer and Its Relations with Diseases, Drugs, and Genes: A Literature-Based Approach

PubMed Central

Song, Min

2016-01-01

In biomedicine, scientific literature is a valuable source for knowledge discovery. Mining knowledge from textual data has become an ever important task as the volume of scientific literature is growing unprecedentedly. In this paper, we propose a framework for examining a certain disease based on existing information provided by scientific literature. Disease-related entities that include diseases, drugs, and genes are systematically extracted and analyzed using a three-level network-based approach. A paper-entity network and an entity co-occurrence network (macro-level) are explored and used to construct six entity specific networks (meso-level). Important diseases, drugs, and genes as well as salient entity relations (micro-level) are identified from these networks. Results obtained from the literature-based literature mining can serve to assist clinical applications. PMID:27195695

49 CFR 604.31 - Service.

Code of Federal Regulations, 2010 CFR

2010-10-01

... the proceeding, the person shall promptly file notice of the change with FTA and the Presiding... in the Charter Service Complaint docket FTA-2007-0025. (c) Who must be served. Copies of all documents filed with FTA shall be served by the entity filing them on all parties to the proceeding. A...

Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity

PubMed Central

Karim, Sabiha; Asad, Muhammad Hassham Hassan Bin; Kalsoom Khan, Abida; Malik, Arif; Chen, Chunye

2015-01-01

The exposure to ultraviolet radiations (UVR) is the key source of skin sunburn; it may produce harmful entities, reactive oxygen species (ROS), leading to aging. The skin can be treated and protected from the injurious effects of ROS by using various pharmaceutical formulations, such as cream. Cream can be loaded with antioxidants to quench ROS leading to photo-protective effects. Moreover, modern medicines depend on ethnobotanicals for protection or treatment of human diseases. This review article summarizes various in vivo antioxidant studies on herbal creams loaded with phyto-extracts. These formulations may serve as cosmeceuticals to protect skin against injurious effects of UVR. The botanicals studied for dermatologic use in cream form include Acacia nilotica, Benincasa hispida, Calendula officinalis, Camellia sinensis, Camellia sinensis, Nelumbo nucifera, Capparis decidua, Castanea sativa, Coffea arabica, Crocus sativus, Emblica officinalis Gaertn, Foeniculum vulgare, Hippophae rhamnoides, Lithospermum erythrorhizon, Malus domestica, Matricaria chamomilla L., Moringa oleifera, Morus alba, Ocimum basilicum, Oryza sativa, Polygonum minus, Punica granatum, Silybum marianum, Tagetes erecta Linn., Terminalia chebula, Trigonella foenum-graecum, and Vitis vinifera. The observed anti-aging effects of cream formulations could be an outcome of a coordinating action of multiple constituents. Of numerous botanicals, the phenolic acids and flavonoids appear effective against UVR-induced damage; however the evidence-based studies for their anti-aging effects are still needed. PMID:26448818

76 FR 52274 - Expansion of State Home Care for Parents of a Child Who Died While Serving in the Armed Forces

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-22

... programs or the rights and obligations of recipients thereof; or (4) raise novel legal or policy issues... impact on a substantial number of small entities as they are defined in the Regulatory Flexibility Act. The State homes referenced in this final rule are State government entities under the control of State...

Efficient authentication scheme based on near-ring root extraction problem

NASA Astrophysics Data System (ADS)

Muthukumaran, V.; Ezhilmaran, D.

2017-11-01

An authentication protocolis the type of computer communication protocol or cryptography protocol specifically designed for transfer of authentication data between two entities. We have planned a two new entity authentication scheme on the basis of root extraction problem near-ring in this article. We suggest that this problem is suitably difficult to serve as a cryptographic assumption over the platform of near-ring N. The security issues also discussed.

An optimization-based approach for facility energy management with uncertainties, and, Power portfolio optimization in deregulated electricity markets with risk management

NASA Astrophysics Data System (ADS)

Xu, Jun

Topic 1. An Optimization-Based Approach for Facility Energy Management with Uncertainties. Effective energy management for facilities is becoming increasingly important in view of the rising energy costs, the government mandate on the reduction of energy consumption, and the human comfort requirements. This part of dissertation presents a daily energy management formulation and the corresponding solution methodology for HVAC systems. The problem is to minimize the energy and demand costs through the control of HVAC units while satisfying human comfort, system dynamics, load limit constraints, and other requirements. The problem is difficult in view of the fact that the system is nonlinear, time-varying, building-dependent, and uncertain; and that the direct control of a large number of HVAC components is difficult. In this work, HVAC setpoints are the control variables developed on top of a Direct Digital Control (DDC) system. A method that combines Lagrangian relaxation, neural networks, stochastic dynamic programming, and heuristics is developed to predict the system dynamics and uncontrollable load, and to optimize the setpoints. Numerical testing and prototype implementation results show that our method can effectively reduce total costs, manage uncertainties, and shed the load, is computationally efficient. Furthermore, it is significantly better than existing methods. Topic 2. Power Portfolio Optimization in Deregulated Electricity Markets with Risk Management. In a deregulated electric power system, multiple markets of different time scales exist with various power supply instruments. A load serving entity (LSE) has multiple choices from these instruments to meet its load obligations. In view of the large amount of power involved, the complex market structure, risks in such volatile markets, stringent constraints to be satisfied, and the long time horizon, a power portfolio optimization problem is of critical importance but difficulty for an LSE to serve the load, maximize its profit, and manage risks. In this topic, a mid-term power portfolio optimization problem with risk management is presented. Key instruments are considered, risk terms based on semi-variances of spot market transactions are introduced, and penalties on load obligation violations are added to the objective function to improve algorithm convergence and constraint satisfaction. To overcome the inseparability of the resulting problem, a surrogate optimization framework is developed enabling a decomposition and coordination approach. Numerical testing results show that our method effectively provides decisions for various instruments to maximize profit, manage risks, and is computationally efficient.

77 FR 26686 - Transmission Planning Reliability Standards

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-07

... Normal (No Contingency) Conditions (Category A), TPL-002-1b--System Performance Following Loss of a... Reliability Standard should not allow an entity to plan for the loss of non-consequential firm load in the... approval of its proposal to revise and clarify footnote `b' ``in regard to load loss following a single...

75 FR 67752 - Request for Nominations of Candidates To Serve on the Interagency Committee on Smoking and Health...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-03

... DEPARTMENT OF HEALTH AND HUMAN SERVICES (HHS) Centers for Disease Control and Prevention (CDC) Request for Nominations of Candidates To Serve on the Interagency Committee on Smoking and Health, (ICSH... entities, federal agencies, and State and local public health agencies with respect to smoking and health...

USGS Colorado Water Science Center bookmark

USGS Publications Warehouse

,

2016-12-05

The U.S. Geological Survey Colorado Water Science Center conducts its water-resources activities primarily in Colorado in cooperation with more than 125 different entities. These activities include extensive data-collection efforts and studies of streamflow, water quality, and groundwater to address many specific issues of concern to Colorado water-management entities and citizens. The collected data are provided in the National Water Information System, and study results are documented in reports and information served on the Internet.

7 CFR 4284.508 - Use of grant funds.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., small businesses and other similar entities in rural areas served by the Center: (a) Applied research... accordance with the subpart. (e) Providing technical assistance, research services and advisory services for...

Business Entity Selection: Why It Matters to Healthcare Practitioners. Part III--Nonprofits, Ethics, Practice Implications, and Conclusions.

PubMed

Nithman, Robert W

2015-01-01

The Bureau of Labor statistics indicates only a 50% four-year survivability rate among businesses classified as "education and health services." Gaining knowledge of IRS business entities can result in cost savings, operational efficiency, reduced liability, and enhanced sustainability. Each entity has unique disadvantages, depending on size, diversity of ownership, desire to expand, and profitability. Business structures should be compatible with organizational mission or vision statements, services and products, and professional codes of ethics. Healthcare reform will require greater business acumen. We have an ethical duty to disseminate and acquire the knowledge to properly establish and manage healthcare practices to ensure sustainable services that protect and serve the community.

The EPSA Project Finance Mapping Tool

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hadley, Stanton W.; Chinthavali, Supriya

The Energy Policy and Systems Analysis Office of DOE has requested a tool to compare the impact of various Federal policies on the financial viability of generation resources across the country. Policy options could include production tax credits, investment tax credits, solar renewable energy credits, tax abatement, accelerated depreciation, tax-free loans, and others. The tool would model the finances of projects in all fifty states, and possibly other geographic units like utility service territories and RTO/ISO territories. The tool would consider the facility s cost, financing, production, and revenues under different capital and market structures to determine things like levelizedmore » cost of energy, return on equity, and cost impacts on others (e.g., load-serving entities, society.) The tool would compare the cost and value of the facility to the local regional alternatives to determine how and where policy levers may provide sufficient incremental value to motivate investment. The results will be displayed through a purpose-built visualization that maps geographic variations and shows associated figures and tables.« less

Western Wind Strategy: Addressing Critical Issues for Wind Deployment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Douglas Larson; Thomas Carr

2012-03-30

The goal of the Western Wind Strategy project was to help remove critical barriers to wind development in the Western Interconnection. The four stated objectives of this project were to: (1) identify the barriers, particularly barriers to the operational integration of renewables and barriers identified by load-serving entities (LSEs) that will be buying wind generation, (2) communicate the barriers to state officials, (3) create a collaborative process to address those barriers with the Western states, utilities and the renewable industry, and (4) provide a role model for other regions. The project has been on the forefront of identifying and informingmore » state policy makers and utility regulators of critical issues related to wind energy and the integration of variable generation. The project has been a critical component in the efforts of states to push forward important reforms and innovations that will enable states to meet their renewable energy goals and lower the cost to consumers of integrating variable generation.« less

Correlates of illness severity in infectious mononucleosis

PubMed Central

Odame, John; Robinson, Joan; Khodai-Booran, Nasser; Yeung, Simon; Mazzulli, Tony; Stephens, Derek; Allen, Upton D

2014-01-01

INTRODUCTION: Understanding the spectrum and frequencies of Epstein-Barr virus (EBV) complications and markers of illness severity in immunocompetent patients with primary EBV infection will inform management of patients with EBV-related illnesses. OBJECTIVES: To determine the clinical and laboratory correlates of illness severity among infants, children and youth with infectious mononucleosis (IM). METHODS: Study subjects with confirmed IM were prospectively enrolled. Illness severity was assessed at baseline and at six weeks using a scoring tool. Peripheral blood viral loads served as a measure of viral burden. RESULTS: Among 32 children and young adults with IM, the median age was 16 years (range two to 24 years). The predominant clinical findings were lymphadenopathy (23 of 32 [72%]), pharyngitis (16 of 32 [50%]), fever (nine of 32 [28%]) and splenomegaly (six of 32 [19%]). With respect to symptoms or signs that persisted to at least six weeks after illness onset, the predominant complaint was lymphadenopathy in 35% of subjects available for reassessment. Deranged liver function tests were present at presentation in up to 44% of subjects. Patients with the highest viral loads at presentation had significantly higher illness severity scores associated with fatigue (P=0.02). Other than the scores associated with fatigue, viral load values were not significantly correlated with the illness severity scores at baseline and at six weeks. CONCLUSION: In IM, viral loads are not necessarily correlated with illness severity, with the exception of fatigue. EBV-related hepatitis is common in IM, confirming the status of this virus as a relatively common cause of transient hepatitis in children and youth. This entity is not necessarily a marker of disease severity. PMID:25371691

Accumulo/Hadoop, MongoDB, and Elasticsearch Performance for Semi Structured Intrusion Detection (IDS) Data

DTIC Science & Technology

2016-11-01

iii Contents List of Figures v 1. Introduction 1 2. Background 1 3. Yahoo ! Cloud Serving Benchmark (YCSB) 2 3.1 Data Loading and Performance...transactional system. 3. Yahoo ! Cloud Serving Benchmark (YCSB) 3.1 Data Loading and Performance Testing Framework When originally setting out to perform the...that referred to a data loading and performance testing framework, Yahoo ! Cloud Serving Benchmark (YCSB).12 This framework is freely available and

Sister Mary K. Samson v. The United States. Religious institutes and the IRS: the Samson Case's impact.

PubMed

Roha, T A

1985-04-01

A federal appeals court recently ruled that a member of a Catholic religious institute assigned by her superiors to serve with a county hospital was subject to Social Security withholding on earnings from that service. Consequently, Catholic institute members will have Social Security taxes withheld whenever they serve with an entity not associated with the Church, that is, any entity not listed in the Official Catholic Directory. The ruling hinges on the contention that the sister could not have been "required" by her superiors to serve with the county hospital, since the hospital had final authority to determine who its employees would be, and that she thereby failed to qualify for the exception to Social Security withholding in Internal Revenue Code section 3121(b)(8)(A) for members of religious institutes performing service "'required" by their superiors. Because virtually all employers have this final authority, however, the appeals court's ruling leaves in doubt the perimeters of the exception to Social Security withholding in section 3121(b)(8)(A).

42 CFR 56.704 - Grant evaluation and award.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 319(g) of the Act and applicable regulations of this part, taking into consideration: (a) The cost-effectiveness of the application; and (b) The number of centers and entities to be served by the applicant. ...

28 CFR 58.3 - Qualification for membership on panels of private trustees.

Code of Federal Regulations, 2014 CFR

2014-07-01

... individual in a non-supervisory position. No professional corporation, partnership, or similar entity organized for the practice of law or accounting shall be eligible to serve on the panel. (b) The...

28 CFR 58.3 - Qualification for membership on panels of private trustees.

Code of Federal Regulations, 2011 CFR

2011-07-01

... individual in a non-supervisory position. No professional corporation, partnership, or similar entity organized for the practice of law or accounting shall be eligible to serve on the panel. (b) The...

28 CFR 58.3 - Qualification for membership on panels of private trustees.

Code of Federal Regulations, 2012 CFR

2012-07-01

... individual in a non-supervisory position. No professional corporation, partnership, or similar entity organized for the practice of law or accounting shall be eligible to serve on the panel. (b) The...

13 CFR 119.11 - What information will be requested in an application under the PRIME program?

Code of Federal Regulations, 2011 CFR

2011-01-01

... applicant's community partnerships and collaborations with state and local entities, and a description of how such partnerships and collaborations are serving microentrepreneurs. (4) A description of the...

76 FR 5178 - Statement of Organization, Functions, and Delegations of Authority

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-28

... and advocacy network to serve eligible beneficiaries of the program; paying benefits and handling... coordinating with a number of public and private entities, including the Department of the Treasury, the Social...

Business entity selection: why it matters to healthcare practitioners--part I--Conceptual framework, sole proprietorships, and partnerships.

PubMed

Nithman, Robert W

2015-01-01

The Bureau of Labor statistics indicates only a 50% four-year survivability rate among businesses classified as "education and health services." Gaining knowledge of IRS business entities can result in cost savings, operational efficiency, reduced liability, and enhanced sustainability. Each entity has unique disadvan- tages, depending on size, diversity of ownership, desire to expand, and profitability. Business structures should be compatible with the organizational mission or vision statement, services and products, and professional codes of ethics. Healthcare reform will require greater business acumen. We have an ethical duty to disseminate and acquire the knowledge to properly establish and manage healthcare practices to ensure sustainable services that protect and serve the community.

18 CFR 16.10 - Information to be provided by an applicant for new license: Filing requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... applicant's operating and load characteristics; and (C) The communities served or to be served, including... the contributions from the applicant's generation, purchases, and load modification measures (such as...; and (C) If load management measures are not viewed as resources, the effects of such measures on the...

18 CFR 16.10 - Information to be provided by an applicant for new license: Filing requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... applicant's operating and load characteristics; and (C) The communities served or to be served, including... the contributions from the applicant's generation, purchases, and load modification measures (such as...; and (C) If load management measures are not viewed as resources, the effects of such measures on the...

18 CFR 16.10 - Information to be provided by an applicant for new license: Filing requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... applicant's operating and load characteristics; and (C) The communities served or to be served, including... the contributions from the applicant's generation, purchases, and load modification measures (such as...; and (C) If load management measures are not viewed as resources, the effects of such measures on the...

18 CFR 16.10 - Information to be provided by an applicant for new license: Filing requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... applicant's operating and load characteristics; and (C) The communities served or to be served, including... the contributions from the applicant's generation, purchases, and load modification measures (such as...; and (C) If load management measures are not viewed as resources, the effects of such measures on the...

18 CFR 16.10 - Information to be provided by an applicant for new license: Filing requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... applicant's operating and load characteristics; and (C) The communities served or to be served, including... the contributions from the applicant's generation, purchases, and load modification measures (such as...; and (C) If load management measures are not viewed as resources, the effects of such measures on the...

Computer-generated forces in distributed interactive simulation

NASA Astrophysics Data System (ADS)

Petty, Mikel D.

1995-04-01

Distributed Interactive Simulation (DIS) is an architecture for building large-scale simulation models from a set of independent simulator nodes communicating via a common network protocol. DIS is most often used to create a simulated battlefield for military training. Computer Generated Forces (CGF) systems control large numbers of autonomous battlefield entities in a DIS simulation using computer equipment and software rather than humans in simulators. CGF entities serve as both enemy forces and supplemental friendly forces in a DIS exercise. Research into various aspects of CGF systems is ongoing. Several CGF systems have been implemented.

Mesh Oriented datABase

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tautges, Timothy J.

MOAB is a component for representing and evaluating mesh data. MOAB can store stuctured and unstructured mesh, consisting of elements in the finite element "zoo". The functional interface to MOAB is simple yet powerful, allowing the representation of many types of metadata commonly found on the mesh. MOAB is optimized for efficiency in space and time, based on access to mesh in chunks rather than through individual entities, while also versatile enough to support individual entity access. The MOAB data model consists of a mesh interface instance, mesh entities (vertices and elements), sets, and tags. Entities are addressed through handlesmore » rather than pointers, to allow the underlying representation of an entity to change without changing the handle to that entity. Sets are arbitrary groupings of mesh entities and other sets. Sets also support parent/child relationships as a relation distinct from sets containing other sets. The directed-graph provided by set parent/child relationships is useful for modeling topological relations from a geometric model or other metadata. Tags are named data which can be assigned to the mesh as a whole, individual entities, or sets. Tags are a mechanism for attaching data to individual entities and sets are a mechanism for describing relations between entities; the combination of these two mechanisms isa powerful yet simple interface for representing metadata or application-specific data. For example, sets and tags can be used together to describe geometric topology, boundary condition, and inter-processor interface groupings in a mesh. MOAB is used in several ways in various applications. MOAB serves as the underlying mesh data representation in the VERDE mesh verification code. MOAB can also be used as a mesh input mechanism, using mesh readers induded with MOAB, or as a t’anslator between mesh formats, using readers and writers included with MOAB.« less

7 CFR 1260.161 - Establishment and membership.

Code of Federal Regulations, 2010 CFR

2010-01-01

....161 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BEEF... serve on the Committee and to disclose any relationship with any beef promotion entity or with any...

7 CFR 1260.144 - Nominee's agreement to serve.

Code of Federal Regulations, 2010 CFR

2010-01-01

....144 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BEEF... appointed; and (b) Disclose any relationship with any beef promotion entity or with any organization that...

7 CFR 1220.213 - Establishment and membership.

Code of Federal Regulations, 2010 CFR

2010-01-01

....213 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN... written agreement to serve on the Committee and to disclose any relationship with any soybean entity or...

7 CFR 1220.205 - Nominee's agreement to serve.

Code of Federal Regulations, 2010 CFR

2010-01-01

....205 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN...) Agree to disclose any relationship with any soybean promotion entity or with any organization that has...

The @neurIST Ontology of Intracranial Aneurysms: Providing Terminological Services for an Integrated IT Infrastructure

PubMed Central

Boeker, Martin; Stenzhorn, Holger; Kumpf, Kai; Bijlenga, Philippe; Schulz, Stefan; Hanser, Susanne

2007-01-01

The @neurIST ontology is currently under development within the scope of the European project @neurIST intended to serve as a module in a complex architecture aiming at providing a better understanding and management of intracranial aneurysms and subarachnoid hemorrhages. Due to the integrative structure of the project the ontology needs to represent entities from various disciplines on a large spatial and temporal scale. Initial term acquisition was performed by exploiting a database scaffold, literature analysis and communications with domain experts. The ontology design is based on the DOLCE upper ontology and other existing domain ontologies were linked or partly included whenever appropriate (e.g., the FMA for anatomical entities and the UMLS for definitions and lexical information). About 2300 predominantly medical entities were represented but also a multitude of biomolecular, epidemiological, and hemodynamic entities. The usage of the ontology in the project comprises terminological control, text mining, annotation, and data mediation. PMID:18693797

Informatics in radiology: an information model of the DICOM standard.

PubMed

Kahn, Charles E; Langlotz, Curtis P; Channin, David S; Rubin, Daniel L

2011-01-01

The Digital Imaging and Communications in Medicine (DICOM) Standard is a key foundational technology for radiology. However, its complexity creates challenges for information system developers because the current DICOM specification requires human interpretation and is subject to nonstandard implementation. To address this problem, a formally sound and computationally accessible information model of the DICOM Standard was created. The DICOM Standard was modeled as an ontology, a machine-accessible and human-interpretable representation that may be viewed and manipulated by information-modeling tools. The DICOM Ontology includes a real-world model and a DICOM entity model. The real-world model describes patients, studies, images, and other features of medical imaging. The DICOM entity model describes connections between real-world entities and the classes that model the corresponding DICOM information entities. The DICOM Ontology was created to support the Cancer Biomedical Informatics Grid (caBIG) initiative, and it may be extended to encompass the entire DICOM Standard and serve as a foundation of medical imaging systems for research and patient care. RSNA, 2010

BANNER: an executable survey of advances in biomedical named entity recognition.

PubMed

Leaman, Robert; Gonzalez, Graciela

2008-01-01

There has been an increasing amount of research on biomedical named entity recognition, the most basic text extraction problem, resulting in significant progress by different research teams around the world. This has created a need for a freely-available, open source system implementing the advances described in the literature. In this paper we present BANNER, an open-source, executable survey of advances in biomedical named entity recognition, intended to serve as a benchmark for the field. BANNER is implemented in Java as a machine-learning system based on conditional random fields and includes a wide survey of the best techniques recently described in the literature. It is designed to maximize domain independence by not employing brittle semantic features or rule-based processing steps, and achieves significantly better performance than existing baseline systems. It is therefore useful to developers as an extensible NER implementation, to researchers as a standard for comparing innovative techniques, and to biologists requiring the ability to find novel entities in large amounts of text.

A continuous function model for path prediction of entities

NASA Astrophysics Data System (ADS)

Nanda, S.; Pray, R.

2007-04-01

As militaries across the world continue to evolve, the roles of humans in various theatres of operation are being increasingly targeted by military planners for substitution with automation. Forward observation and direction of supporting arms to neutralize threats from dynamic adversaries is one such example. However, contemporary tracking and targeting systems are incapable of serving autonomously for they do not embody the sophisticated algorithms necessary to predict the future positions of adversaries with the accuracy offered by the cognitive and analytical abilities of human operators. The need for these systems to incorporate methods characterizing such intelligence is therefore compelling. In this paper, we present a novel technique to achieve this goal by modeling the path of an entity as a continuous polynomial function of multiple variables expressed as a Taylor series with a finite number of terms. We demonstrate the method for evaluating the coefficient of each term to define this function unambiguously for any given entity, and illustrate its use to determine the entity's position at any point in time in the future.

7 CFR 1220.205 - Nominee's agreement to serve.

Code of Federal Regulations, 2011 CFR

2011-01-01

... SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Soybean Promotion and Research Order United Soybean Board...) Agree to disclose any relationship with any soybean promotion entity or with any organization that has...

76 FR 2416 - Civil Rights Division, Federal Coordination and Compliance Section; Agency Information Collection...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-13

..., national origin, sex, religion, age, or other bases. Federal Coordination and Compliance Section serves as..., religion, age, or other bases by a public or private entity may, by himself or herself or by an authorized...

7 CFR 1280.203 - Nominee's agreement to serve.

Code of Federal Regulations, 2010 CFR

2010-01-01

....203 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE LAMB... relationship with any lamb promotion entity or with any organization that has or is being considered for a...

47 CFR 76.71 - Scope of application.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND... systems serving 50 or more subscribers, and any multichannel video programming distributor. For purposes of the provisions of this subpart, a multichannel video programming distributor is an entity such as...

47 CFR 76.71 - Scope of application.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND... systems serving 50 or more subscribers, and any multichannel video programming distributor. For purposes of the provisions of this subpart, a multichannel video programming distributor is an entity such as...

47 CFR 76.71 - Scope of application.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND... systems serving 50 or more subscribers, and any multichannel video programming distributor. For purposes of the provisions of this subpart, a multichannel video programming distributor is an entity such as...

47 CFR 76.71 - Scope of application.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND... systems serving 50 or more subscribers, and any multichannel video programming distributor. For purposes of the provisions of this subpart, a multichannel video programming distributor is an entity such as...

Accommodating Ontologies to Biological Reality—Top-Level Categories of Cumulative-Constitutively Organized Material Entities

PubMed Central

Vogt, Lars; Grobe, Peter; Quast, Björn; Bartolomaeus, Thomas

2012-01-01

Background The Basic Formal Ontology (BFO) is a top-level formal foundational ontology for the biomedical domain. It has been developed with the purpose to serve as an ontologically consistent template for top-level categories of application oriented and domain reference ontologies within the Open Biological and Biomedical Ontologies Foundry (OBO). BFO is important for enabling OBO ontologies to facilitate in reliably communicating and managing data and metadata within and across biomedical databases. Following its intended single inheritance policy, BFO's three top-level categories of material entity (i.e. ‘object’, ‘fiat object part’, ‘object aggregate’) must be exhaustive and mutually disjoint. We have shown elsewhere that for accommodating all types of constitutively organized material entities, BFO must be extended by additional categories of material entity. Methodology/Principal Findings Unfortunately, most biomedical material entities are cumulative-constitutively organized. We show that even the extended BFO does not exhaustively cover cumulative-constitutively organized material entities. We provide examples from biology and everyday life that demonstrate the necessity for ‘portion of matter’ as another material building block. This implies the necessity for further extending BFO by ‘portion of matter’ as well as three additional categories that possess portions of matter as aggregate components. These extensions are necessary if the basic assumption that all parts that share the same granularity level exhaustively sum to the whole should also apply to cumulative-constitutively organized material entities. By suggesting a notion of granular representation we provide a way to maintain the single inheritance principle when dealing with cumulative-constitutively organized material entities. Conclusions/Significance We suggest to extend BFO to incorporate additional categories of material entity and to rearrange its top-level material entity taxonomy. With these additions and the notion of granular representation, BFO would exhaustively cover all top-level types of material entities that application oriented ontologies may use as templates, while still maintaining the single inheritance principle. PMID:22253856

12 CFR 613.3100 - Domestic lending.

Code of Federal Regulations, 2013 CFR

2013-01-01

... cooperatives or agricultural credit bank for energy-related or public utility-related purposes that cannot be... electric, telecommunication, cable television, water, or waste treatment services. (4) Rural area means all... cooperatives. (b) Cooperatives and other entities that serve agricultural or aquatic producers—(1) Eligibility...

12 CFR 613.3100 - Domestic lending.

Code of Federal Regulations, 2012 CFR

2012-01-01

... cooperatives or agricultural credit bank for energy-related or public utility-related purposes that cannot be... electric, telecommunication, cable television, water, or waste treatment services. (4) Rural area means all... cooperatives. (b) Cooperatives and other entities that serve agricultural or aquatic producers—(1) Eligibility...

12 CFR 613.3100 - Domestic lending.

Code of Federal Regulations, 2011 CFR

2011-01-01

... cooperatives or agricultural credit bank for energy-related or public utility-related purposes that cannot be... electric, telecommunication, cable television, water, or waste treatment services. (4) Rural area means all... cooperatives. (b) Cooperatives and other entities that serve agricultural or aquatic producers—(1) Eligibility...

12 CFR 613.3100 - Domestic lending.

Code of Federal Regulations, 2014 CFR

2014-01-01

... cooperatives or agricultural credit bank for energy-related or public utility-related purposes that cannot be... electric, telecommunication, cable television, water, or waste treatment services. (4) Rural area means all... cooperatives. (b) Cooperatives and other entities that serve agricultural or aquatic producers—(1) Eligibility...

The Mobile Team of Parasitology-Mycology, a medical entity for educational purposes to serve sick patients.

PubMed

Desoubeaux, G; Simon, E G; Perrotin, D; Chandenier, J

2014-06-01

The Mobile Team of Parasitology-Mycology is a movable entity of the Parasitology-Mycology laboratory of Tours University Hospital, France. In contrast to the usual prerogatives of biomedical laboratories, the Mobile Team of Parasitology-Mycology is requested to intervene directly at bedside in various clinical departments, or even outside the hospital facility. Although its actions are of course primarily devoted to specialized diagnostic and therapeutic purposes, the Mobile Team also plays an important educational role in the medical training of undergraduate or graduate students. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

78 FR 69398 - Applications for New Awards; National Institute on Disability and Rehabilitation Research...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-19

... Rehabilitation Research--Disability and Rehabilitation Research Projects and Centers Program--Minority-Serving... Rehabilitation Research (NIDRR)--Disability and Rehabilitation Research Projects and Centers Program--Minority... the capacity of minority entities to conduct high-quality disability and rehabilitation research by...

40 CFR 238.20 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING DEGRADABLE PLASTIC RING... means the percent increase in length of the plastic material caused by a tensile load. Percent... entities that produce ring carriers ready for use as beverage carriers. Ring carrier means any plastic ring...

40 CFR 238.20 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING DEGRADABLE PLASTIC RING... means the percent increase in length of the plastic material caused by a tensile load. Percent... entities that produce ring carriers ready for use as beverage carriers. Ring carrier means any plastic ring...

40 CFR 238.20 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING DEGRADABLE PLASTIC RING... means the percent increase in length of the plastic material caused by a tensile load. Percent... entities that produce ring carriers ready for use as beverage carriers. Ring carrier means any plastic ring...

40 CFR 238.20 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING DEGRADABLE PLASTIC RING... means the percent increase in length of the plastic material caused by a tensile load. Percent... entities that produce ring carriers ready for use as beverage carriers. Ring carrier means any plastic ring...

40 CFR 238.20 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING DEGRADABLE PLASTIC RING... means the percent increase in length of the plastic material caused by a tensile load. Percent... entities that produce ring carriers ready for use as beverage carriers. Ring carrier means any plastic ring...

Evolutionary relevance facilitates visual information processing.

PubMed

Jackson, Russell E; Calvillo, Dusti P

2013-11-03

Visual search of the environment is a fundamental human behavior that perceptual load affects powerfully. Previously investigated means for overcoming the inhibitions of high perceptual load, however, generalize poorly to real-world human behavior. We hypothesized that humans would process evolutionarily relevant stimuli more efficiently than evolutionarily novel stimuli, and evolutionary relevance would mitigate the repercussions of high perceptual load during visual search. Animacy is a significant component to evolutionary relevance of visual stimuli because perceiving animate entities is time-sensitive in ways that pose significant evolutionary consequences. Participants completing a visual search task located evolutionarily relevant and animate objects fastest and with the least impact of high perceptual load. Evolutionarily novel and inanimate objects were located slowest and with the highest impact of perceptual load. Evolutionary relevance may importantly affect everyday visual information processing.

BiSet: Semantic Edge Bundling with Biclusters for Sensemaking.

PubMed

Sun, Maoyuan; Mi, Peng; North, Chris; Ramakrishnan, Naren

2016-01-01

Identifying coordinated relationships is an important task in data analytics. For example, an intelligence analyst might want to discover three suspicious people who all visited the same four cities. Existing techniques that display individual relationships, such as between lists of entities, require repetitious manual selection and significant mental aggregation in cluttered visualizations to find coordinated relationships. In this paper, we present BiSet, a visual analytics technique to support interactive exploration of coordinated relationships. In BiSet, we model coordinated relationships as biclusters and algorithmically mine them from a dataset. Then, we visualize the biclusters in context as bundled edges between sets of related entities. Thus, bundles enable analysts to infer task-oriented semantic insights about potentially coordinated activities. We make bundles as first class objects and add a new layer, "in-between", to contain these bundle objects. Based on this, bundles serve to organize entities represented in lists and visually reveal their membership. Users can interact with edge bundles to organize related entities, and vice versa, for sensemaking purposes. With a usage scenario, we demonstrate how BiSet supports the exploration of coordinated relationships in text analytics.

About the REL Pacific Region

ERIC Educational Resources Information Center

Regional Educational Laboratory Pacific, 2014

2014-01-01

REL Pacific is one of ten Regional Educational Laboratories established and funded by the U.S. Department of Education's Institute of Education Sciences. Their region encompasses approximately 4.9 million square miles and serves seven Pacific island entities, including American Samoa; the Commonwealth of the Northern Mariana Islands; the Federated…

76 FR 552 - Pesticides; Availability of Pesticide Registration Notice Regarding the Residential Exposure...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-05

... interested persons about important policies, procedures, and registration related decisions, and serve to...: Richard P. Dumas, Pesticide Re- evaluation Division, Office of Pesticide Programs, Environmental... applicability of this action to a particular entity, consult the person listed under FOR FURTHER INFORMATION...

10 CFR 205.374 - Responses from “entities” designated in the application.

Code of Federal Regulations, 2011 CFR

2011-01-01

... analysis of the impact the requested action would have on its system reliability and its ability to supply its own interruptible and firm customers. The effects of the requested action on the ability to serve firm loads shall be clearly distinguished from the ability to serve contractually interruptible loads...

10 CFR 205.374 - Responses from “entities” designated in the application.

Code of Federal Regulations, 2013 CFR

2013-01-01

... analysis of the impact the requested action would have on its system reliability and its ability to supply its own interruptible and firm customers. The effects of the requested action on the ability to serve firm loads shall be clearly distinguished from the ability to serve contractually interruptible loads...

10 CFR 205.374 - Responses from “entities” designated in the application.

Code of Federal Regulations, 2012 CFR

2012-01-01

... analysis of the impact the requested action would have on its system reliability and its ability to supply its own interruptible and firm customers. The effects of the requested action on the ability to serve firm loads shall be clearly distinguished from the ability to serve contractually interruptible loads...

10 CFR 205.374 - Responses from “entities” designated in the application.

Code of Federal Regulations, 2014 CFR

2014-01-01

... analysis of the impact the requested action would have on its system reliability and its ability to supply its own interruptible and firm customers. The effects of the requested action on the ability to serve firm loads shall be clearly distinguished from the ability to serve contractually interruptible loads...

78 FR 255 - Resumption of the Population Estimates Challenge Program

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-03

... governmental unit. In those instances where a non-functioning county-level government or statistical equivalent...) A non-functioning county or statistical equivalent means a sub- state entity that does not function... represents a non-functioning county or statistical equivalent, the governor will serve as the chief executive...

Evidence Use and Advocacy Coalitions: Intermediary Organizations and Philanthropies in Denver, Colorado

ERIC Educational Resources Information Center

Scott, Janelle; Jabbar, Huriya; LaLonde, Priya; DeBray, Elizabeth; Lubienski, Christopher

2015-01-01

The increasing involvement of philanthropists in education policy has contributed to the emergence of a dynamic sector of intermediary organizations (IOs), entities that serve a number of functions in school reform, including advocacy, consultation, policy design, alternative teacher and leadership preparation, and research. In recent years, many…

Pacific Resources for Education and Learning Fact Sheet.

ERIC Educational Resources Information Center

Pacific Resources for Education and Learning, Honolulu, HI.

Pacific Resources for Education and Learning (PREL) is a nonprofit corporation that serves schools in 10 Pacific island political entities, whose affiliation with the United States ranges from statehood to free association. PREL's main office is in Honolulu, Hawaii, with service centers in American Samoa; the Commonwealth of the Northern Mariana…

School Finance and Facilities Study.

ERIC Educational Resources Information Center

Kawakami, Alice J., Ed.

1994-01-01

This document presents findings of a Pacific Region Educational Laboratory (PREL) study on the status of school finance and facilities in the 10 entities of the Pacific region served by PREL--American Samoa, Commonwealth of the Northern Mariana Islands (CNMI), Federated States of Micronesia, Guam, Hawaii, Republic of the Marshall Islands, and the…

47 CFR 90.361 - Interference from part 15 and Amateur operations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... communications of entities eligible under subpart B or C of this part, or is providing the final link for communications of health care providers that serve rural areas, elementary schools, secondary schools or... operations. 90.361 Section 90.361 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND...

18 CFR 16.8 - Consultation requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

....6 of this chapter. (4) The Director of the Office of Energy Projects will, upon request, provide a... otherwise extended by the Director of Office of Energy Projects pursuant to paragraph (b)(6) of this section... Office of Energy Projects (Director) for resolution. (ii) The entity referring the dispute must serve a...

18 CFR 16.8 - Consultation requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

....6 of this chapter. (4) The Director of the Office of Energy Projects will, upon request, provide a... otherwise extended by the Director of Office of Energy Projects pursuant to paragraph (b)(6) of this section... Office of Energy Projects (Director) for resolution. (ii) The entity referring the dispute must serve a...

18 CFR 16.8 - Consultation requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

....6 of this chapter. (4) The Director of the Office of Energy Projects will, upon request, provide a... otherwise extended by the Director of Office of Energy Projects pursuant to paragraph (b)(6) of this section... Office of Energy Projects (Director) for resolution. (ii) The entity referring the dispute must serve a...

25 CFR 32.4 - Policies.

Code of Federal Regulations, 2014 CFR

2014-04-01

... granted by the tribes or Alaska Native entity(ies) served by the school(s). (b) Student rights. Ensure the constitutional, statutory, civil and human rights of all Indian and Alaska Native students, and respect the role... the benefit of all Indian and Alaska Native students, taking into account special educational needs...

25 CFR 32.4 - Policies.

Code of Federal Regulations, 2013 CFR

2013-04-01

... granted by the tribes or Alaska Native entity(ies) served by the school(s). (b) Student rights. Ensure the constitutional, statutory, civil and human rights of all Indian and Alaska Native students, and respect the role... the benefit of all Indian and Alaska Native students, taking into account special educational needs...

25 CFR 32.4 - Policies.

Code of Federal Regulations, 2012 CFR

2012-04-01

... granted by the tribes or Alaska Native entity(ies) served by the school(s). (b) Student rights. Ensure the constitutional, statutory, civil and human rights of all Indian and Alaska Native students, and respect the role... the benefit of all Indian and Alaska Native students, taking into account special educational needs...

45 CFR 2519.500 - How does the Corporation review an application?

Code of Federal Regulations, 2011 CFR

2011-10-01

... service projects carried out under the program; (2) Specify how the institution will promote faculty..., or a nonprofit entity that serves or involves school-age youth, older adults, low-income communities..., specify projects that involve leadership development of school-age youth; or (10) Describe the needs that...

45 CFR 2519.500 - How does the Corporation review an application?

Code of Federal Regulations, 2013 CFR

2013-10-01

... service projects carried out under the program; (2) Specify how the institution will promote faculty..., or a nonprofit entity that serves or involves school-age youth, older adults, low-income communities..., specify projects that involve leadership development of school-age youth; or (10) Describe the needs that...

45 CFR 2519.500 - How does the Corporation review an application?

Code of Federal Regulations, 2012 CFR

2012-10-01

... service projects carried out under the program; (2) Specify how the institution will promote faculty..., or a nonprofit entity that serves or involves school-age youth, older adults, low-income communities..., specify projects that involve leadership development of school-age youth; or (10) Describe the needs that...

45 CFR 2519.500 - How does the Corporation review an application?

Code of Federal Regulations, 2014 CFR

2014-10-01

... service projects carried out under the program; (2) Specify how the institution will promote faculty..., or a nonprofit entity that serves or involves school-age youth, older adults, low-income communities..., specify projects that involve leadership development of school-age youth; or (10) Describe the needs that...

Restorer-of-fertility mutations recovered in transposon-active lines of S male-sterile maize

USDA-ARS?s Scientific Manuscript database

Mitochondria execute key pathways of central metabolism and serve as cellular sensing and signaling entities - functions that depend upon interactions between mitochondrial and nuclear genetic systems. This is exemplified in cytoplasmic male sterility type S (CMS-S) of Zea mays, where novel mitochon...

Technology-Oriented Job Preparation. Final Report.

ERIC Educational Resources Information Center

One America, Inc., Washington, DC.

An extensive review of literature dealing with 263 technology-oriented vocational training programs was conducted to gather current information on the state of such training. Particular emphasis was placed on links between programs and government bodies or private sector entities and programs that could serve as models for those wishing to…

Library Reorganization & Restructuring. SPEC Kit 215.

ERIC Educational Resources Information Center

Eustis, Joanne D., Comp.; Kenney, Donald J. Comp.

As the entity traditionally responsible for serving the information needs of the university, research libraries have little choice but to change dramatically in the next 25 years. This SPEC Survey on library reorganization seeks to understand how librarians have sought to meet this challenge through the redesigning of their organization.…

Assembling of stimuli-responsive tumor targeting polypyrrole nanotubes drug carrier system for controlled release.

PubMed

Chen, Jian; Li, Xiufang; Li, Jiawen; Li, Jianbing; Huang, Ling; Ren, Tao; Yang, Xiao; Zhong, Shian

2018-08-01

A stimuli-responsive polypyrrole (PPy) nanotubes drug carrier system has been designed to deliver anticancer drugs to tumor cells in a targeted and controlled manner. The PPy nanotubes drug carrier was fabricated by a template method. The nanotubes surface was functionalized with cleavable acylhydrazone and disulfide bonds by attaching thiolated β-cyclodextrin (β-CD). The solubilizing poly(ethylene glycol) polymer (PEG), attached with an adamantane (Ad) entity at one end and a folate (FA) entity at the other end, was introduced onto the nanotubes surface via β-cyclodextrin-adamantane interaction. The synthesized FA-PEG-Ad-β-CD-PPy showed excellent biocompatibility and low cytotoxicity for two cell lines. Doxorubicin (Dox) loaded FA-PEG-Ad-β-CD-PPy nanotubes showed a triggered in vitro drug release behavior in the presence of acidic media and reducing agents. The folate-mediated endocytosis and intracellular release of Dox-loaded nanoparticles were confirmed by fluorescence microscopy and cell viability evaluations. In the in vitro study, Dox loaded within the nanoparticles showed enhanced selectivity for cancerous cells and reduced cytotoxicity for normal cells compared to free Dox. The PPy based targeted drug vehicle shows excellent promise for drug delivery. Copyright © 2018 Elsevier B.V. All rights reserved.

12 CFR Appendix E to Part 229 - Commentary

Code of Federal Regulations, 2013 CFR

2013-01-01

... by another entity. The Board believes that the statutory proximity test was designed to apply to.... The EFA Act defines a certified check as one to which a bank has certified that the drawer's signature... by regulations.” The Board has defined check processing region as the territory served by one of the...

12 CFR Appendix E to Part 229 - Commentary

Code of Federal Regulations, 2011 CFR

2011-01-01

... by another entity. The Board believes that the statutory proximity test was designed to apply to.... The EFA Act defines a certified check as one to which a bank has certified that the drawer's signature... by regulations.” The Board has defined check processing region as the territory served by one of the...

12 CFR Appendix E to Part 229 - Commentary

Code of Federal Regulations, 2014 CFR

2014-01-01

... by another entity. The Board believes that the statutory proximity test was designed to apply to.... The EFA Act defines a certified check as one to which a bank has certified that the drawer's signature... by regulations.” The Board has defined check processing region as the territory served by one of the...

12 CFR Appendix E to Part 229 - Commentary

Code of Federal Regulations, 2012 CFR

2012-01-01

... by another entity. The Board believes that the statutory proximity test was designed to apply to.... The EFA Act defines a certified check as one to which a bank has certified that the drawer's signature... by regulations.” The Board has defined check processing region as the territory served by one of the...

[The clinical view through the Archives: the clinical notes of 2009].

PubMed

Samolski, Daniel; Martín Robles, Irene; Castillo Villegas, Diego

2010-12-01

The Clinical Notes published in 2009 serve as a resource to reflect on clinical aspects relevant to different clinical entities. Through this review an attempt is likewise made to bring the reader closer to the clinical reality of our environment. Copyright © 2010 SEPAR. Published by Elsevier Espana. All rights reserved.

About BTTC | Center for Cancer Research

Cancer.gov

About Combined Forces Drive BTTC The Brain Tumor Trials Collaborative (BTTC) was created in 2003 - a combined effort of many professionals, entities and organizations to help those suffering from brain tumors. The National Cancer Institute's (NCI) Center for Cancer Research serves as the lead institution and provides the administrative infrastructure, clinical database and

75 FR 64684 - Cost Accounting Standards: Elimination of the Exemption From Cost Accounting Standards for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-20

... financial accounting practices and internal controls. Consistency will be better served by all companies... such as the ownership and control of the company, and whether the contractor's accounting activities... argues that there must be some type of accounting system in foreign entities to ensure that billings...

32 CFR 174.11 - Leasing of real property to non-Federal entities.

Code of Federal Regulations, 2012 CFR

2012-07-01

.... 174.11 Section 174.11 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE... the Secretary determines that: (1) A public interest will be served as a result of the lease; and, (2...) Pending final disposition of an installation, the Secretary concerned may grant interim leases which are...

Designing Student Affairs Organizational Structures: Perceptions of Senior Student Affairs Officers

ERIC Educational Resources Information Center

Kuk, Linda; Banning, James H.

2009-01-01

Student affairs organizations have become complex entities and serve as a critical link to student success and the quality of the overall educational experience in collegiate institutions. Over time, new programs and services have been added to the array of existing programs and services with little attention focused on how these organizations…

Cutting Red Tape: Overcoming State Bureaucracies to Develop High-Performing State Education Agencies

ERIC Educational Resources Information Center

Hanna, Robert; Morrow, Jeffrey S.; Rozen, Marci

2014-01-01

States serve a special role in the nation's public education system. Through elected legislatures, states have endowed their various state departments of education with powers over public education, which include granting authority to local entities--typically school districts--to run schools. In their oversight capacity, states--traditionally…

30 CFR 1218.540 - How does ONRR serve official correspondence?

Code of Federal Regulations, 2014 CFR

2014-07-01

... reporting entity is responsible for notifying ONRR of any name or address changes on Form ONRR-4444. The... name and address, position title, or department name and address in our database, based on previous... registered agent; (ii) Any corporate officer; or (iii) The addressee of record shown in the files of any...

Creativity, Technology, Art, and Pedagogical Practices

ERIC Educational Resources Information Center

Tillander, Michelle

2011-01-01

Creativity serves an important role in culture, education, and the workforce as it "provides the impetus for any act, idea, or product that changes an existing domain or discipline into a new entity." In the 21st century, information technology is forming a powerful alliance with creative practices in the arts and design to establish new domains…

30 CFR 218.540 - How does MMS serve official correspondence?

Code of Federal Regulations, 2010 CFR

2010-07-01

... agent; (ii) Any corporate officer; or (iii) The addressee of record shown in the files of any State Secretary; Corporate Commission; Federal or state agency that keeps official records of business entities or... delivery made pursuant to the law of the State in which the service is effected; or (3) Private mailing...

Satellite Power System (SPS): an Overview of Prospective Organizational Structures in the Solar Satellite Field

NASA Technical Reports Server (NTRS)

Edler, H. G.

1978-01-01

A literature survey, interviews with acknowledged experts in the fields of organizational entities, space, solar energy, and the SPS concept, and an analysis of these inputs to identify the organizational alternatives and make judgments as to their feasibility to serve as patterns for a future SPS entity are presented. Selection and evaluation criteria were determined to include timeliness, reliability, and adequacy to contribute meaningfully to the U.S. supply; political feasibility (both national and international) and cost-effectiveness (including environmental and other external costs). Based on these criteria, four organizational alternatives are discussed which offer reasonable promise as potential options for SPS. These included three domestic alternatives and one international alternative.

Product Development and Commercialization of Diagnostic or Life Science Products for Scientists and Researchers.

PubMed

Alonso, Meghan M

2017-01-01

Commercializing a diagnostic or life science product often encompasses different goals than that of research and grant funding. There are several necessary steps, and a strategy needs to be well defined in order to be successful. Product development requires input from and between various groups within a company and, for academia, outside entities. The product development stakeholder groups/entities are research, marketing, development, regulatory, manufacturing, clinical, safety/efficacy, and quality. After initial research and development, much of the work in product development can be outsourced or jointly created using public-private partnerships. This chapter serves as an overview of the product development process and provides a guide to best define a product strategy.

HANNIBAL REVISITED: ANTISOCIAL PERSONALITY DISORDER VERSUS PSYCHOPATHY--MEDICO-LEGAL PERSPECTIVES FROM SOUTH AFRICA.

PubMed

Stevens, Philip

2014-07-01

Psychopathy and its relation to criminal behaviour has been the focus of clinical research for many years. Within the context of South African criminal law, the impact of psychopathy on criminal liability has been addressed in numerous decisions with varying outcomes all indicative of the reality that psychopathy will at most serve as a factor in mitigation of sentence, but will not exonerate an accused of criminal responsibility. In this contribution, the author reflects on the diagnostic entities of psychopathy and antisocial personality disorder against the backdrop of South African criminal law cases in terms of which either of these entities were raised in support of mitigation of sentence and/or as extenuating circumstances.

Characterizing autopoiesis in the game of life.

PubMed

Beer, Randall D

2015-01-01

Maturana and Varela's concept of autopoiesis defines the essential organization of living systems and serves as a foundation for their biology of cognition and the enactive approach to cognitive science. As an initial step toward a more formal analysis of autopoiesis, this article investigates its application to the compact, recurrent spatiotemporal patterns that arise in Conway's Game-of-Life cellular automaton. In particular, we demonstrate how such entities can be formulated as self-constructing networks of interdependent processes that maintain their own boundaries. We then characterize the specific organizations of several such entities, suggest a way to simplify the descriptions of these organizations, and briefly consider the transformation of such organizations over time.

Design of capacity incentive and energy compensation for demand response programs

NASA Astrophysics Data System (ADS)

Liu, Zhoubin; Cui, Wenqi; Shen, Ran; Hu, Yishuang; Wu, Hui; Ye, Chengjin

2018-02-01

Variability and Uncertainties caused by renewable energy sources have called for large amount of balancing services. Demand side resources (DSRs) can be a good alternative of traditional generating units to provide balancing service. In the areas where the electricity market has not been fully established, e.g., China, DSRs can help balance the power system with incentive-based demand response programs. However, there is a lack of information about the interruption cost of consumers in these areas, making it hard to determine the rational amount of capacity incentive and energy compensation for the participants of demand response programs. This paper proposes an algorithm to calculate the amount of capacity incentive and energy compensation for demand response programs when there lacks the information about interruption cost. Available statistical information of interruption cost in referenced areas is selected as the referenced data. Interruption cost of the targeted area is converted from the referenced area by product per electricity consumption. On this basis, capacity incentive and energy compensation are obtained to minimize the payment to consumers. Moreover, the loss of consumers is guaranteed to be covered by the revenue they earned from load serving entities.

Facile route to versatile nanoplatforms for drug delivery by one-pot self-assembly.

PubMed

Zhou, Xing; Che, Ling; Wei, Yanling; Dou, Yin; Chen, Sha; He, Hongmei; Gong, Hao; Li, Xiaohui; Zhang, Jianxiang

2014-06-01

There is still unmet demand for developing powerful approaches to produce polymeric nanoplatforms with versatile functions and broad applications, which are essential for the successful bench-to-bedside translation of polymeric nanotherapeutics developed in the laboratory. We have discovered a facile, convenient, cost-effective and easily scalable one-pot strategy to assemble various lipophilic therapeutics bearing carboxyl groups into nanomedicines, through which highly effective cargo loading and nanoparticle formation can be achieved simultaneously. Besides dramatically improving water solubility, the assembled nanopharmaceuticals showed significantly higher bioavailability and much better therapeutic activity. These one-pot assemblies may also serve as nanocontainers to effectively accommodate other highly hydrophobic drugs such as paclitaxel (PTX). PTX nanomedicines thus formulated display strikingly enhanced in vitro antitumor activity and can reverse the multidrug resistance of tumor cells to PTX therapy. The special surface chemistry offers these assembled entities the additional capability of efficiently packaging and efficaciously transfecting plasmid DNA, with a transfection efficiency markedly higher than that of commonly used positive controls. Consequently, this one-pot assembly approach provides a facile route to multifunctional nanoplatforms for simultaneous delivery of multiple therapeutics with improved therapeutic significance. Copyright © 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Simple measurement-based admission control for DiffServ access networks

NASA Astrophysics Data System (ADS)

Lakkakorpi, Jani

2002-07-01

In order to provide good Quality of Service (QoS) in a Differentiated Services (DiffServ) network, a dynamic admission control scheme is definitely needed as an alternative to overprovisioning. In this paper, we present a simple measurement-based admission control (MBAC) mechanism for DiffServ-based access networks. Instead of using active measurements only or doing purely static bookkeeping with parameter-based admission control (PBAC), the admission control decisions are based on bandwidth reservations and periodically measured & exponentially averaged link loads. If any link load on the path between two endpoints is over the applicable threshold, access is denied. Link loads are periodically sent to Bandwidth Broker (BB) of the routing domain, which makes the admission control decisions. The information needed in calculating the link loads is retrieved from the router statistics. The proposed admission control mechanism is verified through simulations. Our results prove that it is possible to achieve very high bottleneck link utilization levels and still maintain good QoS.

Symbolic emblems of the Levantine Aurignacians as a regional entity identifier (Hayonim Cave, Lower Galilee, Israel).

PubMed

Tejero, José-Miguel; Belfer-Cohen, Anna; Bar-Yosef, Ofer; Gutkin, Vitaly; Rabinovich, Rivka

2018-05-15

The Levantine Aurignacian is a unique phenomenon in the local Upper Paleolithic sequence, showing greater similarity to the West European classic Aurignacian than to the local Levantine archaeological entities preceding and following it. Herewith we highlight another unique characteristic of this entity, namely, the presence of symbolic objects in the form of notched bones (mostly gazelle scapulae) from the Aurignacian levels of Hayonim Cave, Lower Galilee, Israel. Through both macroscopic and microscopic analyses of the items, we suggest that they are not mere cut marks but rather are intentional (decorative?) human-made markings. The significance of this evidence for symbolic behavior is discussed in its chrono-cultural and geographical contexts. Notched bones are among the oldest symbolic expressions of anatomically modern humans. However, unlike other Paleolithic sites where such findings were reported in single numbers, the number of these items recovered at Hayonim Cave is sufficient to assume they possibly served as an emblem of the Levantine Aurignacian.

GABE: A Cloud Brokerage System for Service Selection, Accountability and Enforcement

ERIC Educational Resources Information Center

Sundareswaran, Smitha

2014-01-01

Much like its meteorological counterpart, "Cloud Computing" is an amorphous agglomeration of entities. It is amorphous in that the exact layout of the servers, the load balancers and their functions are neither known nor fixed. Its an agglomerate in that multiple service providers and vendors often coordinate to form a multitenant system…

Novel agrochemical conjugates with self-assembling behaviour.

PubMed

Liu, Qingtao; Graham, Bim; Hawley, Adrian; Dong, Yao-Da; Boyd, Ben J

2018-02-15

That conjugation of agrichemicals to pro-assembly hydrophobic moieties will enable enhanced compatibility and loading with host lyotropic liquid crystalline carrier matrix, and potentially self-assemble in their own right in aqueous environments. A series of lipid-like agrochemical-conjugates were synthesized using specific amphiphilic entities conjugated onto the agrochemicals, picloram and 2,4-dichlorophenoxyacetic acid (2,4-D). The self-assembly behaviour and compatibility of the novel entities when incorporated into phytantriol and monoolein-based liquid crystalline systems were examined using small angle X-ray scattering, cryo-TEM and polarized optical microscopy. Compared to agrochemical-conjugates with simple alkyl ester groups, the esterification of the agrochemicals with amphiphilic groups such as phytantriol and monoolein led to greater structural compatibility and consequently a greater loading of the agrochemicals in the liquid crystalline systems without destabilizing phase structure. Picloram-monoolein and picloram-monoelaidin can self-assemble to form lamellar structures in water. However, certain agrochemical-conjugates such as picloram-monoelaidin and picloram-PEGn-oleate showed poor compatibility with liquid crystalline systems, resulting in phase separation. Copyright © 2017 Elsevier Inc. All rights reserved.

Iron deposits in post-mortem brains of patients with neurodegenerative and cerebrovascular diseases: a semi-quantitative 7.0 T magnetic resonance imaging study.

PubMed

De Reuck, J L; Deramecourt, V; Auger, F; Durieux, N; Cordonnier, C; Devos, D; Defebvre, L; Moreau, C; Caparros-Lefebvre, D; Leys, D; Maurage, C A; Pasquier, F; Bordet, R

2014-07-01

Accumulation of iron (Fe) is often detected in brains of people suffering from neurodegenerative diseases. However, no studies have compared the Fe load between these disease entities. The present study investigates by T2*-weighted gradient-echo 7.0 T magnetic resonance imaging (MRI) the Fe content in post-mortem brains with different neurodegenerative and cerebrovascular diseases. One hundred and fifty-two post-mortem brains, composed of 46 with Alzheimer's disease (AD), 37 with frontotemporal lobar degeneration (FTLD), 11 with amyotrophic lateral sclerosis, 13 with Lewy body disease, 14 with progressive supranuclear palsy, 16 with vascular dementia (VaD) and 15 controls without a brain disease, were examined. The Fe load was determined semi-quantitatively on T2*-weighted MRI serial brain sections in the claustrum, caudate nucleus, putamen, globus pallidus, thalamus, subthalamic nucleus, hippocampus, mamillary body, lateral geniculate body, red nucleus, substantia nigra and dentate nucleus. The disease diagnosis was made on subsequent neuropathological examination. The Fe load was significantly increased in the claustrum, caudate nucleus and putamen of FTLD brains and to a lesser degree in the globus pallidus, thalamus and subthalamic nucleus. In the other neurodegenerative diseases no Fe accumulation was observed, except for a mild increase in the caudate nucleus of AD brains. In VaD brains no Fe increase was detected. Only FTLD displays a significant Fe load, suggesting that impaired Fe homeostasis plays an important role in the pathogenesis of this heterogeneous disease entity. © 2014 The Author(s) European Journal of Neurology © 2014 EAN.

24 CFR 3400.309 - Absence of liability for good-faith administration.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Absence of liability for good-faith... NMLSR § 3400.309 Absence of liability for good-faith administration. HUD or any organization serving as...-faith action or omission of any officer or employee of any such entity, while acting within the scope of...

24 CFR 3400.309 - Absence of liability for good-faith administration.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Absence of liability for good-faith... NMLSR § 3400.309 Absence of liability for good-faith administration. HUD or any organization serving as...-faith action or omission of any officer or employee of any such entity, while acting within the scope of...

24 CFR 3400.309 - Absence of liability for good-faith administration.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 5 2013-04-01 2013-04-01 false Absence of liability for good-faith... NMLSR § 3400.309 Absence of liability for good-faith administration. HUD or any organization serving as...-faith action or omission of any officer or employee of any such entity, while acting within the scope of...

Speech for the National Black Child Development Institute Conference (St. Louis, Missouri, October 25, 1991).

ERIC Educational Resources Information Center

Clay, William L.

This speech by a black congressman from Missouri concerns the context in which general questions about black children must be answered. These questions include: (1) How can service providers, institutions, and government entities implement a vision for the future of black children? and (2) How can organizations that serve black children ensure…

Providing a Clearer View: An Examination of Transparency on Local Government Websites

ERIC Educational Resources Information Center

Armstrong, Cory L.

2011-01-01

This study examines the role of content professionalism and public outreach, along with partisanship in the availability of online local public information. Comparing county and school board websites in Florida, the author suggests that online public records serve as a proxy for the entity's overall level of transparency. A content analysis of 134…

20 CFR 645.215 - What must a WtW operating entity that serves noncustodial parent participants do?

Code of Federal Regulations, 2011 CFR

2011-04-01

... responsibility contracts: (1) Take into account the employment and child support status of the noncustodial... commitment by the noncustodial parent to cooperate in the payment of child support for the minor child. This... related activities that will enable the noncustodial parent to make regular child support payments. For...

20 CFR 645.215 - What must a WtW operating entity that serves noncustodial parent participants do?

Code of Federal Regulations, 2013 CFR

2013-04-01

... responsibility contracts: (1) Take into account the employment and child support status of the noncustodial... commitment by the noncustodial parent to cooperate in the payment of child support for the minor child. This... related activities that will enable the noncustodial parent to make regular child support payments. For...

20 CFR 645.215 - What must a WtW operating entity that serves noncustodial parent participants do?

Code of Federal Regulations, 2012 CFR

2012-04-01

... responsibility contracts: (1) Take into account the employment and child support status of the noncustodial... commitment by the noncustodial parent to cooperate in the payment of child support for the minor child. This... related activities that will enable the noncustodial parent to make regular child support payments. For...

20 CFR 645.215 - What must a WtW operating entity that serves noncustodial parent participants do?

Code of Federal Regulations, 2014 CFR

2014-04-01

... responsibility contracts: (1) Take into account the employment and child support status of the noncustodial... commitment by the noncustodial parent to cooperate in the payment of child support for the minor child. This... related activities that will enable the noncustodial parent to make regular child support payments. For...

Production facility site selection factors for Texas value-added wood producers

Treesearch

Judd H. Michael; Joanna Teitel; James E. Granskog

1998-01-01

Value-added wood products manufacturers serve an important role in the economies of many U.S. regions and are therefore sought after by entities such as economic development agencies. The reasons why certain locations for a prospective prodution facility would be more attractive to secondary wood industry producers are not clearly understood. Therefore, this research...

Exploring the Repeated Name Penalty and the Overt Pronoun Penalty in Spanish

ERIC Educational Resources Information Center

Gelormini-Lezama, Carlos

2018-01-01

Anaphoric expressions such as repeated names, overt pronouns, and null pronouns serve a major role in the creation and maintenance of discourse coherence. The felicitous use of an anaphoric expression is highly dependent on the discourse salience of the entity introduced by the antecedent. Gordon et al. ("Cogn Sci" 17:311-347, 1993)…

Anaphora: A Cross Disciplinary Survey. Technical Report No. 31.

ERIC Educational Resources Information Center

Nash-Webber, Bonnie Lynn

Two fundamental assumptions guide this survey of recent research on anaphora. The first is that anaphoric expressions do not refer to segments in a text or discourse, but to entities that are assumed to be in the language receiver's mind. The second assumption is that a text serves to suggest the referents for anaphora, as does the nonlinguistic…

Synthetic approaches to the 2009 new drugs.

PubMed

Liu, Kevin K-C; Sakya, Subas M; O'Donnell, Christopher J; Flick, Andrew C; Li, Jin

2011-02-01

New drugs are introduced to the market every year and each individual drug represents a privileged structure for its biological target. These new chemical entities (NCEs) provide insights into molecular recognition and also serve as leads for designing future new drugs. This review covers the syntheses of 21 NCEs marketed in 2009. Copyright © 2011 Elsevier Ltd. All rights reserved.

A Generalized Fraction: An Entity Smaller than One on the Mental Number Line

ERIC Educational Resources Information Center

Kallai, Arava Y.; Tzelgov, Joseph

2009-01-01

The representation of fractions in long-term memory (LTM) was investigated by examining the automatic processing of such numbers in a physical comparison task, and their intentional processing in a numerical comparison task. The size congruity effect (SiCE) served as a marker of automatic processing and consequently as an indicator of the access…

Globalizing Historically Black Business Schools: A Case Study of the Application of Modern Pedagogical Theories of Internationalizing Higher Education

ERIC Educational Resources Information Center

Kedia, Ben L.; Clampit, Jack; Gaffney, Nolan

2014-01-01

The AACSB and AIB have each issued reports aimed at ensuring the internationalization of business schools. Historically Black Colleges and Universities (HBCUs)--as underresourced entities serving an underprivileged constituency--may need additional attention. Unfortunately, neither the AACSB nor AIB reports mention HBCUs. The broader literature is…

78 FR 18976 - Proposed Rate Extension and Opportunities for Public Review and Comment for the Cumberland System

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-28

... & Marketing, Southeastern Power Administration, U.S. Department of Energy, 1166 Athens Tech Road, Elberton...,000 MWh of average annual energy to 25 preference entities that serve 210 preference customers in... customers while the Wolf Creek and Center Hill dam safety repairs are finalized. The Wolf Creek Dam work is...

About BTTC | Center for Cancer Research

Cancer.gov

About Combined Forces Drive BTTC The Brain Tumor Trials Collaborative (BTTC) was created in 2003 - a combined effort of many professionals, entities and organizations to help those suffering from brain tumors. The National Cancer Institute's (NCI) Center for Cancer Research serves as the lead institution and provides the administrative infrastructure, clinical database and oversight for the collaborative.

Academy for Teacher Excellence: Maximizing Synergy among Partners for Promoting College Access for Latino Teacher Candidates

ERIC Educational Resources Information Center

Flores, Belinda Bustos; Claeys, Lorena

2011-01-01

This case study discusses how educational entities collaborate in meaningful ways to address teaching force representation and shortages in critical fields for diverse populations in urban education settings. The authors examined how the role of a federally funded program, Academy for Teacher Excellence (ATE), at a Hispanic Serving Institution in…

12 CFR 204.130 - Eligibility for NOW accounts.

Code of Federal Regulations, 2010 CFR

2010-01-01

... clarify the types of entities that may maintain NOW accounts at member banks. (b) Individuals. (1) Any individual may maintain a NOW account regardless of the purposes that the funds will serve. Thus, deposits of... under a trade name is eligible to maintain a NOW account in the individual's name or in the “DBA” name...

Are Postgraduate Students "Rational Choosers"? An Investigation of Motivation for Graduate Study amongst International Students in England

ERIC Educational Resources Information Center

Mowjee, Bisma

2013-01-01

In England, since the 1980s, neo-liberalism has dominated political discourse, and its effects have been extending into the higher-education landscape, challenging traditional conceptions of the university as serving the public good and driving them towards becoming corporate entities selling private commodities. This change has created an…

30 CFR 1218.540 - How does ONRR serve official correspondence?

Code of Federal Regulations, 2012 CFR

2012-07-01

... correspondence at issue. The company or reporting entity is responsible for notifying ONRR of any name or address changes on Form MMS-4444. The addressee of record in a part 1290, appeal will be the person or...-4444, we may use the individual name and address, position title, or department name and address in our...

30 CFR 1218.540 - How does ONRR serve official correspondence?

Code of Federal Regulations, 2013 CFR

2013-07-01

... correspondence at issue. The company or reporting entity is responsible for notifying ONRR of any name or address changes on Form ONRR-4444. The addressee of record in a part 1290, appeal will be the person or...-4444, we may use the individual name and address, position title, or department name and address in our...

Vaccines for emerging infectious diseases: Lessons from MERS coronavirus and Zika virus.

PubMed

Maslow, Joel N

2017-12-02

The past decade and a half has been characterized by numerous emerging infectious diseases. With each new threat, there has been a call for rapid vaccine development. Pathogens such as the Middle East Respiratory Syndrome coronavirus (MERS-CoV) and the Zika virus represent either new viral entities or viruses emergent in new geographic locales and characterized by novel complications. Both serve as paradigms for the global spread that can accompany new pathogens. In this paper, we review the epidemiology and pathogenesis of MERS-CoV and Zika virus with respect to vaccine development. The challenges in vaccine development and the approach to clinical trial design to test vaccine candidates for disease entities with a changing epidemiology are discussed.

Vaccines for emerging infectious diseases: Lessons from MERS coronavirus and Zika virus

PubMed Central

Maslow, Joel N.

2017-01-01

ABSTRACT The past decade and a half has been characterized by numerous emerging infectious diseases. With each new threat, there has been a call for rapid vaccine development. Pathogens such as the Middle East Respiratory Syndrome coronavirus (MERS-CoV) and the Zika virus represent either new viral entities or viruses emergent in new geographic locales and characterized by novel complications. Both serve as paradigms for the global spread that can accompany new pathogens. In this paper, we review the epidemiology and pathogenesis of MERS-CoV and Zika virus with respect to vaccine development. The challenges in vaccine development and the approach to clinical trial design to test vaccine candidates for disease entities with a changing epidemiology are discussed. PMID:28846484

Thermal pollution in rivers: Will adding gravel help to cool them down?

Treesearch

Marie Oliver; Gordon Grant; Barbara Burkholder

2011-01-01

Thermal pollution in rivers can be caused by dams, logging, municipal wastewater treatment, and other human activities. High water termperatures stress ecosystems, kill fish, and promote disease and parasites, and so dam operators, timber companies, and municipalities are held responsible for thermal loading caused by their operations. These entities are looking for...

An algorithmic interactive planning framework in support of sustainable technologies

NASA Astrophysics Data System (ADS)

Prica, Marija D.

This thesis addresses the difficult problem of generation expansion planning that employs the most effective technologies in today's changing electric energy industry. The electrical energy industry, in both the industrialized world and in developing countries, is experiencing transformation in a number of different ways. This transformation is driven by major technological breakthroughs (such as the influx of unconventional smaller-scale resources), by industry restructuring, changing environmental objectives, and the ultimate threat of resource scarcity. This thesis proposes a possible planning framework in support of sustainable technologies where sustainability is viewed as a mix of multiple attributes ranging from reliability and environmental impact to short- and long-term efficiency. The idea of centralized peak-load pricing, which accounts for the tradeoffs between cumulative operational effects and the cost of new investments, is the key concept in support of long-term planning in the changing industry. To start with, an interactive planning framework for generation expansion is posed as a distributed decision-making model. In order to reconcile the distributed sub-objectives of different decision makers with system-wide sustainability objectives, a new concept of distributed interactive peak load pricing is proposed. To be able to make the right decisions, the decision makers must have sufficient information about the estimated long-term electricity prices. The sub-objectives of power plant owners and load-serving entities are profit maximization. Optimized long-term expansion plans based on predicted electricity prices are communicated to the system-wide planning authority as long-run bids. The long-term expansion bids are cleared by the coordinating planner so that the system-wide long-term performance criteria are satisfied. The interactions between generation owners and the coordinating planning authority are repeated annually. We view the proposed interactive planning framework as a necessary paradigm for planning in the changing industry where choice must be reconciled with societal public objectives.

78 FR 75669 - Order Granting a Temporary Exemption Pursuant to Section 36(a)(1) of the Securities Exchange Act...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-12

... from which they will select an entity to serve as the consolidated audit trail (``CAT'') plan processor to build, operate, administer, and maintain the CAT.\\10\\ Thirty-one firms, including four distinct... formulating the CAT NMS Plan, and, ultimately, select the CAT plan processor. \\10\\ In the February 7, 2013...

Professionalizing the Field and Increasing Quality: A Community Effort

ERIC Educational Resources Information Center

Montes, Gladys

2012-01-01

It started with a dream: to create a national best practices teaching and learning center that would not only provide the best available care and education to children ages 0 to 5 years old, but would also serve as a model for adult learners and like-minded entities and individuals in the early education arena. Committed to elevating the quality…

Building Bridges for Collaborative Digital Reference between Libraries and Museums through an Examination of Reference in Special Collections

ERIC Educational Resources Information Center

Lavender, Kenneth; Nicholson, Scott; Pomerantz, Jeffrey

2005-01-01

While a growing number of the digital reference services in libraries have become part of collaborative reference networks, other entities that serve similar information-seeking needs such as special collections and museums have not joined these networks, even though they are answering an increasing number of questions from off-site patrons via…

77 FR 31513 - Patient Protection and Affordable Care Act; Establishment of Exchanges and Qualified Health Plans...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-29

... the final rule, interim final rule, published in the Federal Register on March 27, 2012, entitled...)(2) of the final rule that at least two types of entities must serve as Navigators.'' On page 18336... of personally identifiable information in Sec. 155.260(a) of the proposed rule published on July 15...

77 FR 68807 - Notice of Intent To Prepare an Environmental Impact Statement (EIS) for the Halletts Point...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-16

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5669-N-01] Notice of Intent To Prepare... City of New York--Department of Housing Preservation & Development (HPD), as the Responsible Entity in accordance with 24 CFR 58.2(a)(7), and the New York City Department of City Planning (DCP) serving as lead...

78 FR 66970 - In the Matter of Michael J. Buhrman; Order Prohibiting Involvement in NRC-Licensed Activities...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-07

... governmental entities participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires participants to submit and serve all... procedures described below. To comply with the procedural requirements of E-Filing, at least ten 10 days...

78 FR 5511 - Virgil C. Summer Nuclear Station, Units 2 and 3; Application and Amendment to Facility Combined...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-25

... (E-Filing) All documents filed in the NRC adjudicatory proceedings, including a request for hearing... entities participating under 10 CFR 2.315(c), must be filed in accordance with the NRC's E-Filing rule (72 FR 49139; August 28, 2007). The E-Filing process requires participants to submit and serve all...

76 FR 54261 - Carolina Power & Light; H.B. Robinson Steam Electric Plant, Unit No. 2; HBRSEP Independent Spent...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-31

... via electronic submission through the NRC E-Filing system. Requests for a hearing and petitions for... entities participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires participants to submit and serve all adjudicatory...

75 FR 11202 - Southern Nuclear Operating Company; Notice of Consideration of Issuance of Amendment to Facility...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-10

... governmental entities participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires participants to submit and serve all... accordance with the procedures described below. To comply with the procedural requirements of E-Filing, at...

75 FR 42465 - Exelon Generation Company, LLC; Notice of Consideration of Issuance of Amendment to Facility...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-21

... governmental entities participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires participants to submit and serve all... procedures described below. To comply with the procedural requirements of E-Filing, at least ten (10) days...

76 FR 41532 - Yankee Atomic Electric Company, Yankee Nuclear Power Station (Yankee-Rowe); Notice of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-14

... electronic submission through the NRC E-filing system. Requests for a hearing and petitions for leave to... entities participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires participants to submit and serve all adjudicatory...

76 FR 41530 - Connecticut Yankee Atomic Power Company, Haddam Neck Plant; Notice of Consideration of Approval...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-14

... intervention via electronic submission through the NRC E-filing system. Requests for a hearing and petitions... entities participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires participants to submit and serve all adjudicatory...

78 FR 2451 - Grand Gulf ESP Site; Consideration of Approval of Application Regarding Proposed Creation of a...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-11

... request a hearing and intervention via electronic submission through the NRC's E-filing system. Requests... entities participating under 10 CFR 2.315(c), must be filed in accordance with the NRC's E-Filing rule (72 FR 49139; August 28, 2007). The E-Filing process requires participants to submit and serve all...

75 FR 11572 - Notice of Acceptance for Docketing of the Application, Notice of Opportunity for Hearing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-11

... governmental entities participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires participants to submit and serve all... procedures described below. To comply with the procedural requirements of E-Filing, at least ten (10) days...

Using Electroencephalography to Measure Cognitive Load

ERIC Educational Resources Information Center

Antonenko, Pavlo; Paas, Fred; Grabner, Roland; van Gog, Tamara

2010-01-01

Application of physiological methods, in particular electroencephalography (EEG), offers new and promising approaches to educational psychology research. EEG is identified as a physiological index that can serve as an online, continuous measure of cognitive load detecting subtle fluctuations in instantaneous load, which can help explain effects of…

Computing architecture for autonomous microgrids

DOEpatents

Goldsmith, Steven Y.

2015-09-29

A computing architecture that facilitates autonomously controlling operations of a microgrid is described herein. A microgrid network includes numerous computing devices that execute intelligent agents, each of which is assigned to a particular entity (load, source, storage device, or switch) in the microgrid. The intelligent agents can execute in accordance with predefined protocols to collectively perform computations that facilitate uninterrupted control of the .

The left temporal pole is a heteromodal hub for retrieving proper names

PubMed Central

Waldron, Eric J.; Manzel, Kenneth; Tranel, Daniel

2015-01-01

The left temporal pole (LTP) has been posited to be a heteromodal hub for retrieving proper names for semantically unique entities. Previous investigations have demonstrated that LTP is important for retrieving names for famous faces and unique landmarks. However, whether such a relationship would hold for unique entities apprehended through stimulus modalities other than vision has not been well established, and such evidence is critical to adjudicate claims about the “heteromodal” nature of the LTP. Here, we tested the hypothesis that the LTP would be important for naming famous voices. Individuals with LTP lesions were asked to recognize and name famous persons speaking in audio clips. Relative to neurologically normal and brain damaged comparison participants, patients with LTP lesions were able to recognize famous persons from their voices normally, but were selectively impaired in naming famous persons from their voices. The current results extend previous research and provide further support for the notion that the LTP is a convergence region serving as a heteromodal hub for retrieving the names of semantically unique entities. PMID:24389260

Prevalence of somatic mitochondrial mutations and spatial distribution of mitochondria in non-small cell lung cancer.

PubMed

Kazdal, Daniel; Harms, Alexander; Endris, Volker; Penzel, Roland; Kriegsmann, Mark; Eichhorn, Florian; Muley, Thomas; Stenzinger, Albrecht; Pfarr, Nicole; Weichert, Wilko; Warth, Arne

2017-07-11

Mitochondria are considered relevant players in many tumour entities and first data indicate beneficial effects of mitochondria-targeted antioxidants in both cancer prevention and anticancer therapies. To further dissect the potential roles of mitochondria in NSCLC we comprehensively analysed somatic mitochondrial mutations, determined the spatial distribution of mitochondrial DNA within complete tumour sections and investigated the mitochondrial load in a large-scale approach. Whole mitochondrial genome sequencing of 26 matched tumour and non-neoplastic tissue samples extended by reviewing published data of 326 cases. Systematical stepwise real-time PCR quantification of mitochondrial DNA covering 16 whole surgical tumour sections. Immunohistochemical determination of the mitochondrial load in 171 adenocarcinoma and 145 squamous cell carcinoma. Our results demonstrate very low recurrences (max. 1.7%) and a broad distribution of 456 different somatic mitochondrial mutations. Large inter- and intra-tumour heterogeneity were seen for mitochondrial DNA copy numbers in conjunction with a correlation to the predominant histological growth pattern. Furthermore, tumour cells had significantly higher mitochondrial level compared to adjacent stroma, whereas differences between tumour entities were negligible. Non-evident somatic mitochondrial mutations and highly varying mitochondrial DNA level delineate challenges for the approach of mitochondria-targeted anticancer therapies in NSCLC.

Dual immobilization and magnetic manipulation of magnetic nanoparticles

NASA Astrophysics Data System (ADS)

Yang, S. Y.; Jian, Z. F.; Horng, H. E.; Hong, Chin-Yih; Yang, H. C.; Wu, C. C.; Lee, Y. H.

By suitably bio-functionalizing the surfaces, magnetic nanoparticles are able to bind specific biomolecules, and may serve as vectors for delivering bio-entities to target tissues. In this work, the synthesis of bio-functionalized magnetic nanoparticles with two kinds of bio-probes is developed. Here, the stem cell is selected as a to-be-delivered bio-entity and infarcted myocardium is the target issue. Thus, cluster designation-34 (CD-34) on stem cell and creatine kinase-MB (CK-MB) (or troponin I) on infarcted myocardium are the specific biomolecules to be bound with bio-functionalized magnetic nanoparticles. In addition to demonstrating the co-coating of two kinds of bio-probes on a magnetic nanoparticle, the feasibility of manipulation on bio-functionalized magnetic nanoparticles by external magnetic fields is investigated.

Extensive calvarial tuberculosis: rare complication of tuberculous mastoiditis.

PubMed

Thandar, M A; Fagan, J J; Garb, M

2004-01-01

Tuberculous mastoiditis is a well-documented entity with decreasing incidence in recent years. Tuberculous osteitis of the skull is even rarer. The case of a 58-year-old male with tuberculous mastoiditis complicated by extensive tuberculous osteitis of the skull is presented. This case serves to demonstrate both the difficulty in establishing the diagnosis of tuberculosis and the potentially disastrous consequences of the disease.

Computer Assisted Exercises - Background

DTIC Science & Technology

2003-06-01

standard JSAF interface devices. As a result of this HITL capability, Red and Blue engaged in real-time, dynamic free - play . Further, JSAF permitted...Red- vs.-Blue, free play , entity-level synthetic battlespace. JSAF simulates warfare at the platform level. JSAF simulates the entire range of...works to ensure the free play of events maintains a course that serves the overall objectives. 2-34 This slide has been deliberately left blank

75 FR 30074 - Notice of Docketing, Proposed Action, and Opportunity for a Hearing for Renewal of Special...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-28

... hearing, in accordance with the NRC E-Filing rule, which the NRC promulgated on August 28, 2007 (72 FR... entities participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires participants to submit and serve all adjudicatory...

78 FR 6839 - Duke Energy Carolinas, LLC, Oconee Nuclear Station, Units 1, 2, and 3 Denial of Amendment to...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-31

... entities participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR 49139; August 28, 2007). The E-Filing process requires participants to submit and serve all adjudicatory... procedures described below. To comply with the procedural requirements of E-Filing, at least 10 days prior to...

76 FR 70766 - Notice of Application From FMRI for Consent to an Indirect Change of Control for Source Material...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-15

... Submissions (E-Filing) All documents filed in NRC adjudicatory proceedings, including a request for hearing, a... entities participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires participants to submit and serve all adjudicatory...

VOLTTRON™: Tech-to-Market Best-Practices Guide for Small- and Medium-Sized Commercial Buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cort, Katherine A.; Haack, Jereme N.; Katipamula, Srinivas

VOLTTRON™ is an open-source distributed control and sensing platform developed by Pacific Northwest National Laboratory for the U.S. Department of Energy. It was developed to be used by the Office of Energy Efficiency and Renewable Energy to support transactive controls research and deployment activities. VOLTTRON is designed to be an overarching integration platform that could be used to bring together vendors, users, and developers and enable rapid application development and testing. The platform is designed to support modern control strategies, including the use of agent- and transaction-based controls. It also is designed to support the management of a wide rangemore » of applications, including heating, ventilation, and air-conditioning systems; electric vehicles; and distributed-energy and whole-building loads. This report was completed as part of the Building Technologies Office’s Technology-to-Market Initiative for VOLTTRON’s Market Validation and Business Case Development efforts. The report provides technology-to-market guidance and best practices related to VOLTTRON platform deployments and commercialization activities for use by entities serving small- and medium-sized commercial buildings. The report characterizes the platform ecosystem within the small- and medium-sized commercial building market and articulates the value proposition of VOLTTRON for three core participants in this ecosystem: 1) platform owners/adopters, 2) app developers, and 3) end-users. The report also identifies key market drivers and opportunities for open platform deployments in the small- and medium-sized commercial building market. Possible pathways to the market are described—laboratory testing to market adoption to commercialization. We also identify and address various technical and market barriers that could hinder deployment of VOLTTRON. Finally, we provide “best practice” tech-to-market guidance for building energy-related deployment efforts serving small- and medium-sized commercial buildings.« less

A method of constructing geo-object ontology in disaster system for prevention and decrease

NASA Astrophysics Data System (ADS)

Li, Bin; Liu, Jiping; Shi, Lihong; Wang, Zhenfeng

2009-10-01

A kind of formal system, which can express clearly a certain entity or information, is needed to express geographical concept. Besides, some rules explaining the interrelationship and action between different components are also required. Therefore, the conception of geo-object ontology is introduced. It is a shared formalization and display specification of conceptual knowledge system in the field of concrete application of spatial information science. It can constitute hierarchy structure, which derives from the concept classification system in the geographical area. Its concepts can be described by the property. Property sets can form a vector space with multi-dimensional characteristics. Geographic space is composed of different types of geographic entities. And its concept is formed by a series of geographic entities with the same properties and actions. Moreover, each of the geographic entities can be mapped to an object, and each object has its spatial property, time information and topology, semantic relationships associated with other objects. The biggest difference between ecumenical information ontology and geo-ontology is that the latter has the spatial characteristics. During the construction process of geo-object ontology, some important components, such as geographic type, spatial relation, spatial entity type and coordinates, time, should be included to make further research. Here, taking disaster as an example, by using Protégé and OWL, combined methods used by constructing the geo-object ontology in the form of being manual made by domanial experts and semi-automatic are investigated oriented to disaster to serve ultimately geographic information retrieval service driven by ontology.

Co-optimization of Energy and Demand-Side Reserves in Day-Ahead Electricity Markets

NASA Astrophysics Data System (ADS)

Surender Reddy, S.; Abhyankar, A. R.; Bijwe, P. R.

2015-04-01

This paper presents a new multi-objective day-ahead market clearing (DAMC) mechanism with demand-side reserves/demand response (DR) offers, considering realistic voltage-dependent load modeling. The paper proposes objectives such as social welfare maximization (SWM) including demand-side reserves, and load served error (LSE) minimization. In this paper, energy and demand-side reserves are cleared simultaneously through co-optimization process. The paper clearly brings out the unsuitability of conventional SWM for DAMC in the presence of voltage-dependent loads, due to reduction of load served (LS). Under such circumstances multi-objective DAMC with DR offers is essential. Multi-objective Strength Pareto Evolutionary Algorithm 2+ (SPEA 2+) has been used to solve the optimization problem. The effectiveness of the proposed scheme is confirmed with results obtained from IEEE 30 bus system.

Assessment of disease named entity recognition on a corpus of annotated sentences.

PubMed

Jimeno, Antonio; Jimenez-Ruiz, Ernesto; Lee, Vivian; Gaudan, Sylvain; Berlanga, Rafael; Rebholz-Schuhmann, Dietrich

2008-04-11

In recent years, the recognition of semantic types from the biomedical scientific literature has been focused on named entities like protein and gene names (PGNs) and gene ontology terms (GO terms). Other semantic types like diseases have not received the same level of attention. Different solutions have been proposed to identify disease named entities in the scientific literature. While matching the terminology with language patterns suffers from low recall (e.g., Whatizit) other solutions make use of morpho-syntactic features to better cover the full scope of terminological variability (e.g., MetaMap). Currently, MetaMap that is provided from the National Library of Medicine (NLM) is the state of the art solution for the annotation of concepts from UMLS (Unified Medical Language System) in the literature. Nonetheless, its performance has not yet been assessed on an annotated corpus. In addition, little effort has been invested so far to generate an annotated dataset that links disease entities in text to disease entries in a database, thesaurus or ontology and that could serve as a gold standard to benchmark text mining solutions. As part of our research work, we have taken a corpus that has been delivered in the past for the identification of associations of genes to diseases based on the UMLS Metathesaurus and we have reprocessed and re-annotated the corpus. We have gathered annotations for disease entities from two curators, analyzed their disagreement (0.51 in the kappa-statistic) and composed a single annotated corpus for public use. Thereafter, three solutions for disease named entity recognition including MetaMap have been applied to the corpus to automatically annotate it with UMLS Metathesaurus concepts. The resulting annotations have been benchmarked to compare their performance. The annotated corpus is publicly available at ftp://ftp.ebi.ac.uk/pub/software/textmining/corpora/diseases and can serve as a benchmark to other systems. In addition, we found that dictionary look-up already provides competitive results indicating that the use of disease terminology is highly standardized throughout the terminologies and the literature. MetaMap generates precise results at the expense of insufficient recall while our statistical method obtains better recall at a lower precision rate. Even better results in terms of precision are achieved by combining at least two of the three methods leading, but this approach again lowers recall. Altogether, our analysis gives a better understanding of the complexity of disease annotations in the literature. MetaMap and the dictionary based approach are available through the Whatizit web service infrastructure (Rebholz-Schuhmann D, Arregui M, Gaudan S, Kirsch H, Jimeno A: Text processing through Web services: Calling Whatizit. Bioinformatics 2008, 24:296-298).

PDBj Mine: design and implementation of relational database interface for Protein Data Bank Japan

PubMed Central

Kinjo, Akira R.; Yamashita, Reiko; Nakamura, Haruki

2010-01-01

This article is a tutorial for PDBj Mine, a new database and its interface for Protein Data Bank Japan (PDBj). In PDBj Mine, data are loaded from files in the PDBMLplus format (an extension of PDBML, PDB's canonical XML format, enriched with annotations), which are then served for the user of PDBj via the worldwide web (WWW). We describe the basic design of the relational database (RDB) and web interfaces of PDBj Mine. The contents of PDBMLplus files are first broken into XPath entities, and these paths and data are indexed in the way that reflects the hierarchical structure of the XML files. The data for each XPath type are saved into the corresponding relational table that is named as the XPath itself. The generation of table definitions from the PDBMLplus XML schema is fully automated. For efficient search, frequently queried terms are compiled into a brief summary table. Casual users can perform simple keyword search, and 'Advanced Search' which can specify various conditions on the entries. More experienced users can query the database using SQL statements which can be constructed in a uniform manner. Thus, PDBj Mine achieves a combination of the flexibility of XML documents and the robustness of the RDB. Database URL: http://www.pdbj.org/ PMID:20798081

Role of the Twin-Arginine Translocation Pathway in Staphylococcus▿ †

PubMed Central

Biswas, Lalitha; Biswas, Raja; Nerz, Christiane; Ohlsen, Knut; Schlag, Martin; Schäfer, Tina; Lamkemeyer, Tobias; Ziebandt, Anne-Kathrin; Hantke, Klaus; Rosenstein, Ralf; Götz, Friedrich

2009-01-01

In Staphylococcus, the twin-arginine translocation (Tat) pathway is present only in some species and is composed of TatA and TatC. The tatAC operon is associated with the fepABC operon, which encodes homologs to an iron-binding lipoprotein, an iron-dependent peroxidase (FepB), and a high-affinity iron permease. The FepB protein has a typical twin-arginine (RR) signal peptide. The tat and fep operons constitute an entity that is not present in all staphylococcal species. Our analysis was focused on Staphylococcus aureus and S. carnosus strains. Tat deletion mutants (ΔtatAC) were unable to export active FepB, indicating that this enzyme is a Tat substrate. When the RR signal sequence from FepB was fused to prolipase and protein A, their export became Tat dependent. Since no other protein with a Tat signal could be detected, the fepABC-tatAC genes comprise not only a genetic but also a functional unit. We demonstrated that FepABC drives iron import, and in a mouse kidney abscess model, the bacterial loads of ΔtatAC and Δtat-fep mutants were decreased. For the first time, we show that the Tat pathway in S. aureus is functional and serves to translocate the iron-dependent peroxidase FepB. PMID:19633084

PDBj Mine: design and implementation of relational database interface for Protein Data Bank Japan.

PubMed

Kinjo, Akira R; Yamashita, Reiko; Nakamura, Haruki

2010-08-25

This article is a tutorial for PDBj Mine, a new database and its interface for Protein Data Bank Japan (PDBj). In PDBj Mine, data are loaded from files in the PDBMLplus format (an extension of PDBML, PDB's canonical XML format, enriched with annotations), which are then served for the user of PDBj via the worldwide web (WWW). We describe the basic design of the relational database (RDB) and web interfaces of PDBj Mine. The contents of PDBMLplus files are first broken into XPath entities, and these paths and data are indexed in the way that reflects the hierarchical structure of the XML files. The data for each XPath type are saved into the corresponding relational table that is named as the XPath itself. The generation of table definitions from the PDBMLplus XML schema is fully automated. For efficient search, frequently queried terms are compiled into a brief summary table. Casual users can perform simple keyword search, and 'Advanced Search' which can specify various conditions on the entries. More experienced users can query the database using SQL statements which can be constructed in a uniform manner. Thus, PDBj Mine achieves a combination of the flexibility of XML documents and the robustness of the RDB. Database URL: http://www.pdbj.org/

A Study of Demand Response Effect of Thermal Storage Air-Conditioning Systems in Consideration of Electricity Market Prices

NASA Astrophysics Data System (ADS)

Omagari, Yuko; Sugihara, Hideharu; Tsuji, Kiichiro

This paper evaluates the economic impact of the introduction of customer-owned Thermal Storage Air-conditioning (TSA) systems, in an electricity market, from the viewpoint of the load service entity. We perform simulations on the condition that several thousand customers install TSA systems and shift peak demand in an electricity market by one percent. Our numerical results indicate that the purchase cost of the LSE was reduced through load management of customers with TSA systems. The introduction of TSA systems also reduced the volatility of market clearing price and reduced the whole-trade cost in an electricity market.

The load shedding advisor: An example of a crisis-response expert system

NASA Technical Reports Server (NTRS)

Bollinger, Terry B.; Lightner, Eric; Laverty, John; Ambrose, Edward

1987-01-01

A Prolog-based prototype expert system is described that was implemented by the Network Operations Branch of the NASA Goddard Space Flight Center. The purpose of the prototype was to test whether a small, inexpensive computer system could be used to host a load shedding advisor, a system which would monitor major physical environment parameters in a computer facility, then recommend appropriate operator reponses whenever a serious condition was detected. The resulting prototype performed significantly to efficiency gains achieved by replacing a purely rule-based design methodology with a hybrid approach that combined procedural, entity-relationship, and rule-based methods.

40 CFR 130.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... quality of water and serve the purposes of the Act. (e) Load or loading. An amount of matter or thermal energy that is introduced into a receiving water; to introduce matter or thermal energy into a receiving...

40 CFR 130.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... quality of water and serve the purposes of the Act. (e) Load or loading. An amount of matter or thermal energy that is introduced into a receiving water; to introduce matter or thermal energy into a receiving...

40 CFR 130.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... quality of water and serve the purposes of the Act. (e) Load or loading. An amount of matter or thermal energy that is introduced into a receiving water; to introduce matter or thermal energy into a receiving...

20 CFR 664.810 - How does a Local Board or other entity become eligible to receive a Youth Opportunity Grant?

Code of Federal Regulations, 2012 CFR

2012-04-01

... not have an EZ or an EC and that has been designated by its Governor as a high poverty area; or (3) Is... board may apply for a Youth Opportunity Grant, and that meets the poverty rate criteria in section 1392... WIA section 166; and (2) Serves a community that: (i) Meets the poverty rate criteria in section 1392...

20 CFR 664.810 - How does a Local Board or other entity become eligible to receive a Youth Opportunity Grant?

Code of Federal Regulations, 2014 CFR

2014-04-01

... not have an EZ or an EC and that has been designated by its Governor as a high poverty area; or (3) Is... board may apply for a Youth Opportunity Grant, and that meets the poverty rate criteria in section 1392... WIA section 166; and (2) Serves a community that: (i) Meets the poverty rate criteria in section 1392...

20 CFR 664.810 - How does a Local Board or other entity become eligible to receive a Youth Opportunity Grant?

Code of Federal Regulations, 2013 CFR

2013-04-01

... not have an EZ or an EC and that has been designated by its Governor as a high poverty area; or (3) Is... board may apply for a Youth Opportunity Grant, and that meets the poverty rate criteria in section 1392... WIA section 166; and (2) Serves a community that: (i) Meets the poverty rate criteria in section 1392...

Highlights of GAO’s Corporate Governance, Transparency and Accountability Forum

DTIC Science & Technology

2002-03-01

the current accounting and reporting model does not adequately address (e.g., special purpose entities, uncovered arbitrage positions)? • Is there...TRANSPARENCY AND ACCOUNTABILITY FORUM a GAO-02-494SP Report Documentation Page Report Date 00MAR2002 Report Type N/A Dates Covered (from...its oversight in connection with these matters. In particular, the Congress and GAO are interested in changes that could serve to reduce the

Opportunities and Challenges in Supply-Side Simulation: Physician-Based Models

PubMed Central

Gresenz, Carole Roan; Auerbach, David I; Duarte, Fabian

2013-01-01

Objective To provide a conceptual framework and to assess the availability of empirical data for supply-side microsimulation modeling in the context of health care. Data Sources Multiple secondary data sources, including the American Community Survey, Health Tracking Physician Survey, and SK&A physician database. Study Design We apply our conceptual framework to one entity in the health care market—physicians—and identify, assess, and compare data available for physician-based simulation models. Principal Findings Our conceptual framework describes three broad types of data required for supply-side microsimulation modeling. Our assessment of available data for modeling physician behavior suggests broad comparability across various sources on several dimensions and highlights the need for significant integration of data across multiple sources to provide a platform adequate for modeling. A growing literature provides potential estimates for use as behavioral parameters that could serve as the models' engines. Sources of data for simulation modeling that account for the complex organizational and financial relationships among physicians and other supply-side entities are limited. Conclusions A key challenge for supply-side microsimulation modeling is optimally combining available data to harness their collective power. Several possibilities also exist for novel data collection. These have the potential to serve as catalysts for the next generation of supply-side-focused simulation models to inform health policy. PMID:23347041

Dual-Band Microstrip Antenna With Reactive Loading

NASA Technical Reports Server (NTRS)

Davidson, Shayla E.

1988-01-01

Effective but bulky coaxial stub replaced. Short-circuited microstrip transmission line serves as reactive loading element for microstrip antenna. Constructed integrally with stripline radiating element, shorted line preserves low microstrip profile and enables tuning of antenna for two-band operation.

Finite element analysis of thrust angle contact ball slewing bearing

NASA Astrophysics Data System (ADS)

Deng, Biao; Guo, Yuan; Zhang, An; Tang, Shengjin

2017-12-01

In view of the large heavy slewing bearing no longer follows the rigid ring hupothesis under the load condition, the entity finite element model of thrust angular contact ball bearing was established by using finite element analysis software ANSYS. The boundary conditions of the model were set according to the actual condition of slewing bearing, the internal stress state of the slewing bearing was obtained by solving and calculation, and the calculated results were compared with the numerical results based on the rigid ring assumption. The results show that more balls are loaded in the result of finite element method, and the maximum contact stresses between the ball and raceway have some reductions. This is because the finite element method considers the ferrule as an elastic body. The ring will produce structure deformation in the radial plane when the heavy load slewing bearings are subjected to external loads. The results of the finite element method are more in line with the actual situation of the slewing bearing in the engineering.

Ada 9X Project Revision Request Report. Supplement 1

DTIC Science & Technology

1990-01-01

Non-portable use of operating system primitives or of Ada run time system internals. POSSIBLE SOLUTIONS: Mandate that compilers recognize tasks that...complex than a simple operating system file, the compiler vendor must provide routines to manipulate it (create, copy, move etc .) as a single entity... system , to support fault tolerance, load sharing, change of system operating mode etc . It is highly desirable that such important software be written in

2012 White Book, Pacific Northwest Loads and Resources Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

The White Book is a planning analysis produced by BPA that informs BPA of its load and resource conditions for sales and purchases. The White Book provides a 10-year look at the expected obligations and resources in the Federal system and PNW region. The White Book is used as a planning tool for the Columbia River Treaty (Treaty) studies, as an information tool for customers and regional interests, and as a publication of information utilized by other planning entities for their analyses. The White Book is not used to guide day-to-day operations of the Federal Columbia River Power System (FCRPS)more » or determine BPA revenues or rates.« less

A Game Changer: Electrifying Remote Communities by Using Isolated Microgrids

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lu, Xiaonan; Wang, Jianhui

Microgrids, as self-contained entities, are of increasing interest in modern electric grids. Microgrids provide a sustainable solution to aggregate distributed energy resources (DERs) [e.g., photovoltaics (PVs), wind turbines], energy storage, and loads in a localized manner, especially in distribution systems. As a controllable unit, a microgrid can manage and balance the source and load power inside it to ensure stable and reliable operation. Moreover, through coordination with upper-level control systems, it can be dispatched and respond to the control commands issued by the central controller in the distribution system-in other words, a system that is effectively a distribution management systemmore » (DMS).« less

1995 Pacific Northwest Loads and Resources Study.

DOE Office of Scientific and Technical Information (OSTI.GOV)

United States. Bonneville Power Administration.

1995-12-01

The study establishes the planning basis for supplying electricity to customers. The study presents projections of regional and Federal system load and resource capabilities, and serves as a benchmark for annual BPA determinations made pursuant to the 1981 regional power sales contracts.

Quality of Bone Healing: Perspectives and Assessment Techniques

DTIC Science & Technology

2014-01-01

connective tissue specialized for load bearing . Embryologically, the formation of bone occurs via two routes: intramembranous and endochondral ossification.1...primarily suited to load bearing with two distinct configurations: an inner, porous, cancellous architecture and an outer, denser, cortical bone...delineate the multiple functions served by the human skeleton and then evaluate techniques for clinical assessment. Mechanical load bearing and transduction

Enhancing the Behaviorial Fidelity of Synthetic Entities with Human Behavior Models

DTIC Science & Technology

2004-05-05

reflecting the soldier’s extensive training. A civilian’s behavior in the same situation will be determined more by emotions , such as fear, and goals...of intelligent behavior , from path-planning to emotional effects, data on the environment must be gathered from the simulation to serve as sensor...model of decision-making based on emotional utility. AI.Implant takes a composite behavior -based approach to individual and crowd navigation

I Am Not Captain Dunsel! A (Former) Head of an Academic Branch Library Replies to Steven Bell

ERIC Educational Resources Information Center

Redalje, Susanne J.

2009-01-01

For those unfamiliar with Star Trek, "Dunsel" was a term introduced in the episode titled "The Ultimate Computer." It is a term used by Star Fleet cadets to refer to an entity that serves no useful purpose, in this case a human who has been replaced by a machine. The episode touches on finding the best balance between human and machine to run a…

20 CFR 664.810 - How does a Local Board or other entity become eligible to receive a Youth Opportunity Grant?

Code of Federal Regulations, 2011 CFR

2011-04-01

... EZ or an EC and that has been designated by its Governor as a high poverty area; or (3) Is one of two... for a Youth Opportunity Grant, and that meets the poverty rate criteria in section 1392 (a)(4), (b... 166; and (2) Serves a community that: (i) Meets the poverty rate criteria in section 1392(a)(4), (b...

20 CFR 664.810 - How does a Local Board or other entity become eligible to receive a Youth Opportunity Grant?

Code of Federal Regulations, 2010 CFR

2010-04-01

... EZ or an EC and that has been designated by its Governor as a high poverty area; or (3) Is one of two... for a Youth Opportunity Grant, and that meets the poverty rate criteria in section 1392 (a)(4), (b... 166; and (2) Serves a community that: (i) Meets the poverty rate criteria in section 1392(a)(4), (b...

Drug Development and Biologics in Asthma. A New Era.

PubMed

Doyle, Ramona

2016-03-01

Considerable progress has been made toward developing targeted biological therapeutics for asthma, due in large part to a deeper understanding of asthma pathophysiology. This explosion of knowledge has revealed asthma to be a much more complex and heterogeneous entity than previously understood. The identification of particular asthma phenotypes with distinct pathophysiologic mechanisms has opened up a new era for patient populations not well served by current therapies, especially patients with severe asthma.

Effects of Backpack Frame Length, Pack Load, and Participation Time on the Physical Performance of Men and Women

DTIC Science & Technology

1983-08-01

procedures and results for this project on the Biomechanics of Load Carrying Behavior. The work was formulated and directed by Drs. Carolyn K. Bensel...The first of these loads had a mass of approximately 26 kg, including all clothing and equipment worn or carried by the subject, and served as a...rifle, which weighed 3.17 kg, and the ALICE load carrying system. The pack, which weighed 1.10 kg, was loaded with Army clothing and equipment items

Regional climate response collaboratives: Multi-institutional support for climate resilience

USGS Publications Warehouse

Averyt, Kristen; Derner, Justin D.; Dilling, Lisa; Guerrero, Rafael; Joyce, Linda A.; McNeeley, Shannon; McNie, Elizabeth; Morisette, Jeffrey T.; Ojima, Dennis; O'Malley, Robin; Peck, Dannele; Ray, Andrea J.; Reeves, Matt; Travis, William

2018-01-01

Federal investments by U.S. agencies to enhance climate resilience at regional scales grew over the past decade (2010s). To maximize efficiency and effectiveness in serving multiple sectors and scales, it has become critical to leverage existing agency-specific research, infrastructure, and capacity while avoiding redundancy. We discuss lessons learned from a multi-institutional “regional climate response collaborative” that comprises three different federally-supported climate service entities in the Rocky Mountain west and northern plains region. These lessons include leveraging different strengths of each partner, creating deliberate mechanisms to increase cross-entity communication and joint ownership of projects, and placing a common priority on stakeholder-relevant research and outcomes. We share the conditions that fostered successful collaboration, which can be transferred elsewhere, and suggest mechanisms for overcoming potential barriers. Synergies are essential for producing actionable research that informs climate-related decisions for stakeholders and ultimately enhances climate resilience at regional scales.

Commercial investigation results for the generic bioprocessing apparatus flown on United States Microgravity Laboratory-1

NASA Technical Reports Server (NTRS)

Stodieck, Louis S.; Robinson, M. C.; Luttges, M. W.

1994-01-01

The Generic Bioprocessing Apparatus (BPA) payload was developed by BioServe to support the commercial flight development needs of our specialized consortia comprised of business, academic, and government entities. The consortia have commitments to explore commercial opportunities in bioprocessing, biomedical models, and closed agricultural systems. In addition, some members of BioServe have interests in the development and/or qualification of enabling flight hardware used in life sciences space flight testing. Some business and academic entities have interests in more than one of these consortia. To aid in payload development, flight, and analysis, each consortium member contributes resources ranging from proprietary expertise and materials, to hardware and cash. Professionals from business, academia, and government often interact with each other via graduate research assistants who do much of the 'hands-on' payload preparation and subsequent data analyses. The GBA supported research, testing, and development activities for each different BioServe consortium. It produced an environment in which professionals from diverse backgrounds came together with a single focus. And, it provided a truly novel learning environment for a youthful new cadre of space professionals committed to the exploration of commercial opportunities presented by space. Since the GBA supported a large number of different experiments, this paper briefly describes the payload characteristics and the essential operations of the payload. A summary of the experiments is presented. Finally, a few of the experiments are described in detail highlighting some novel effects of space flight on life science systems. Portions of the reported work have or will appear in appropriate archival journals as cited in the bibliography. In several instances, data collected from USML-1 have been supplemented with related data collected on more recent STS missions.

Determining if Borderline Personality Disorder and Bipolar Disorder Are Alternative Expressions of the Same Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions.

PubMed

de la Rosa, Iris; Oquendo, María A; García, Gemma; Stanley, Barbara; González-Pinto, Ana; Liu, Shang-Min; Blanco, Carlos

To examine whether bipolar disorder and borderline personality disorder represent 2 different disorders or alternative manifestations of the same disorder. The data were collected between January 1, 2004, and December 31, 2005. The analyses were conducted between December 21 and December 27, 2010. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were performed on 25 symptoms assessing depression, mania, and borderline personality disorder from the National Epidemiologic Survey on Alcohol and Related Conditions, a large nationally representative sample of the US adult population (N = 34,653). DSM-IV criteria were used for diagnosis of bipolar disorder and borderline personality disorder. A 3-factor solution provided an excellent fit in both the EFA (root mean square error of approximation [RMSEA] = 0.017, comparative fix index [CFI] = 0.997) and the CFA (RMSEA = 0.024, CFI = 0.993). Factor 1 (Borderline Personality Disorder) loaded on all 9 borderline personality disorder symptoms, factor 2 (Depression) loaded on 8 symptoms of depression, and factor 3 (Mania) loaded on 7 symptoms of mania plus the psychomotor agitation item of the depression section. The correlations between the Borderline Personality Disorder and Depression factors (r = 0.328) and between the Borderline Personality Disorder and Mania factors (r = 0.394) were lower than the correlation between Depression and Mania factors (r = 0.538). A model with 3 positively correlated factors provided an excellent fit for the latent structure of borderline personality disorder and bipolar disorder symptoms. The pattern of pairwise correlations between the 3 factors is consistent with the clinical presentation of 2 syndromes (depression and mania) that can be characterized as a unitary psychiatric entity (bipolar disorder) and a third syndrome (borderline personality disorder) that is often comorbid with bipolar disorder. The findings converge in suggesting that bipolar disorder and borderline personality disorder are overlapping but different pathologies. These findings may serve to inform ongoing efforts to refine the existing psychiatric nosology and to suggest new avenues for etiologic and treatment research. © Copyright 2017 Physicians Postgraduate Press, Inc.

7 CFR 1710.404 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... serve the load. Eligible borrower means a utility system that has direct or indirect responsibility for... analysis of energy flows in a building, process, or system with the goal of identifying opportunities to... output. HVAC means heating, ventilation, and air conditioning. Load means the Power delivered to power...

A rare case of low-solute hyponatremia in a nonalcoholic person.

PubMed

Srisung, Weeraporn; Mankongpaisarnrung, Charoen; Anaele, Cyriacus; Dumrongmongcolgul, Nat; Ahmed, Vaqar

2015-01-01

Low-solute hyponatremia is a relatively uncommon entity of euvolemic hyponatremia. Classic cases were described in alcoholics as beer potomania, which is characterized by hyponatremia in the setting of low-solute intake due to heavy beer drinking. We report a case of low-solute hyponatremia in a nonalcoholic person who was given a solute load, and, subsequently, had excessive diuresis with the resultant rapid increase in serum sodium concentration.

Estimating the Contact Endurance of the AISI 321 Stainless Steel Under Contact Gigacycle Fatigue Tests

NASA Astrophysics Data System (ADS)

Savrai, R. A.; Makarov, A. V.; Osintseva, A. L.; Malygina, I. Yu.

2018-02-01

Mechanical testing of the AISI 321 corrosion resistant austenitic steel for contact gigacycle fatigue has been conducted with the application of a new method of contact fatigue testing with ultrasonic frequency of loading according to a pulsing impact "plane-to-plane" contact scheme. It has been found that the contact endurance (the ability to resist the fatigue spalling) of the AISI 321 steel under contact gigacycle fatigue loading is determined by its plasticity margin and the possibility of additional hardening under contact loading. It is demonstrated that the appearance of localized deep and long areas of spalling on a material surface can serve as a qualitative characteristic for the loss of the fatigue strength of the AISI 321 steel under impact contact fatigue loading. The value of surface microhardness measured within contact spots and the maximum depth of contact damages in the peripheral zone of contact spots can serve as quantitative criteria for that purpose.

United States Marine Corps 2012 Financial Report. Schedule of Budgetary Activity for Fiscal Year 2012 Appropriations

DTIC Science & Technology

2012-01-01

activity schedule for current year appropriations that is also compliant with Generally Accepted Accounting Principles ( GAAP ). The audit of this financial...are not only fighters, but also who can serve as trainers, mentors and advisers. Marine Corps Value to the Nation For a remarkably small investment ...who are interested in and could use the information in the statements to help them make resource allocation and other decisions and hold the entity

Treatment of Battlefield Detainees in the War on Terrorism

DTIC Science & Technology

2002-04-11

DoD law of war expert Hayes Parks, who advocates a purely de facto standard, without regard to political factors). 93See INTERNATIONAL COMMITTEE OF...108Military Prosecutor v. Kassem , 47 I.L.R. 470 (1971) (excerpts reprinted in DOCUMENTS ON PRISONERS OF WAR, document no. 160 (U.S. Naval War College 1979...most important consideration given to POW status has been whether there is evidence that they serve a government or political entity that exercises

What are the potential benefits of including latent storage in common wallboard?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stovall, T.K.; Tomlinson, J.J.

1995-11-01

Previous work has shown that wallboard can be successfully manufactured to contain up to 30% phase-change material (PCM), or wax, thus enabling this common building material to serve as a thermal energy storage device. The PCM wallboard was analyzed for passive solar applications and found to save energy with a reasonable payback time period of five years. Further evaluations of the wallboard are reported in this paper. This analysis looks at potential applications of PCM wallboard as a load management device and as a comfort enhancer. Results show that the wallboard is ineffective in modifying the comfort level but canmore » provide significant load management relief. In some applications the load management strategy also serves to save a small amount of energy, in others there is a small energy penalty.« less

Review of the Strength and Capacity Data for Manual Material Handling Activities.

DTIC Science & Technology

1979-11-01

Industrial Association Journal, 1, 1-12, 1973. KEYWORDS: posture, lordosimetry, lunbosacral adjustments, ectomorphs , endomorphs METHODS: Ten women served as...no-load condition, the average lumbosacral angle is close to 130 degrees, and the range of its variation is less for the ectomorphs . Lumbosacral...in reaction to light, load application, ectomorphs tend to arch, and endomorphs tend to straighten. At greater levels of loading, the ectomorphs tend

Characterization of biological particulate loads in metropolitan air

Treesearch

J. A. Snow; R. D. Schein; W. J. Moroz

1977-01-01

The atmospheric particulate load includes a wide range of naturally occurring particles of biological origin that serve as a reservoir of allergenic agents in respiratory disease. Improved knowledge of potential aeroallergens is needed by medical clinicians. Aims are to better characterize air spora, qualitatively and quantitatively, and determine daily (by hour)...

Comprehensive analysis of the transcriptional profile of the Mediator complex across human cancer types.

PubMed

Syring, Isabella; Klümper, Niklas; Offermann, Anne; Braun, Martin; Deng, Mario; Boehm, Diana; Queisser, Angela; von Mässenhausen, Anne; Brägelmann, Johannes; Vogel, Wenzel; Schmidt, Doris; Majores, Michael; Schindler, Anne; Kristiansen, Glen; Müller, Stefan C; Ellinger, Jörg; Shaikhibrahim, Zaki; Perner, Sven

2016-04-26

The Mediator complex is a key regulator of gene transcription and several studies demonstrated altered expressions of particular subunits in diverse human diseases, especially cancer. However a systematic study deciphering the transcriptional expression of the Mediator across different cancer entities is still lacking.We therefore performed a comprehensive in silico cancer vs. benign analysis of the Mediator complex subunits (MEDs) for 20 tumor entities using Oncomine datasets. The transcriptional expression profiles across almost all cancer entities showed differentially expressed MEDs as compared to benign tissue. Differential expression of MED8 in renal cell carcinoma (RCC) and MED12 in lung cancer (LCa) were validated and further investigated by immunohistochemical staining on tissue microarrays containing large numbers of specimen. MED8 in clear cell RCC (ccRCC) associated with shorter survival and advanced TNM stage and showed higher expression in metastatic than primary tumors. In vitro, siRNA mediated MED8 knockdown significantly impaired proliferation and motility in ccRCC cell lines, hinting at a role for MED8 to serve as a novel therapeutic target in ccRCC. Taken together, our Mediator complex transcriptome proved to be a valid tool for identifying cancer-related shifts in Mediator complex composition, revealing that MEDs do exhibit cancer specific transcriptional expression profiles.

Transforming to a computerized system for nursing care: organizational success within Magnet idealism.

PubMed

Lindgren, Carolyn L; Elie, Leslie G; Vidal, Elizabeth C; Vasserman, Alex

2010-01-01

In reaching the goal for standardized, quality care, a not-for-profit healthcare system consisting of seven institutional entities is transforming nursing practice guidelines, patient care workflow, and patient documents into electronic, online, real-time modalities for use across departments and all healthcare delivery entities of the system. Organizational structure and a strategic plan were developed for the 2-year Clinical Transformation Project. The Siemens Patient Care Document System was adopted and adapted to the hospitals' documentation and information needs. Two fast-track sessions of more than 100 nurses and representatives from other health disciplines were held to standardize assessments, histories, care protocols, and interdisciplinary plans of care for the top 10 diagnostic regulatory groups. Education needs of the users were addressed. After the first year, a productive, functional system is evidenced. For example, the bar-coded Medication Administration Check System is in full use on the clinical units of one of the hospitals, and the other institutional entities are at substantial stages of implementation of Patient Care Documentation System. The project requires significant allocation of personnel and financial resources for a highly functional informatics system that will transform clinical care. The project exemplifies four of the Magnet ideals and serves as a model for others who may be deciding about launching a similar endeavor.

The Challenge of New and Emerging Information Operations

DTIC Science & Technology

1999-06-01

Information Dominance Center (IDC) are addressing the operational and technological needs. The IDC serves as a model for the DoD and a proposed virtual hearing room for Congress. As the IDC and its supporting technologies mature, individuals will be able to freely enter, navigate, plan, and execute operations within Perceptual and Knowledge Landscapes. This capability begins the transition from Information Dominance to Knowledge Dominance. The IDC is instantiating such entities as smart rooms, avatars, square pixel displays, polymorphic views, and

Fort Collins Science Center

USGS Publications Warehouse

Banowetz, Michele

2004-01-01

FORT serves all Department of the Interior land management bureaus and other natural resource agencies. In addition, FORT scientists partner with DOI and other federal entities such as CDC, DOE, EPA, NASA, NIH, and USDA to share expertise and resources. FORT also partners with several universities and works cooperatively with states and nongovernmental organizations. Products and services include reports and publications, predictive models and software, maps and GIS products, and other technical assistance in the form of meetings, workshops, training, field visits, and needs assessments.

Site-3 sea anemone toxins: molecular probes of gating mechanisms in voltage-dependent sodium channels.

PubMed

Smith, Jaime J; Blumenthal, Kenneth M

2007-02-01

Sea anemone toxins, whose biological function is the capture of marine prey, are invaluable tools for studying the structure and function of mammalian voltage-gated sodium channels. Their high degree of specificity and selectivity have allowed for detailed analysis of inactivation gating and assignment of molecular entities responsible for this process. Because of their ability to discriminate among channel isoforms, and their high degree of structural conservation, these toxins could serve as important lead compounds for future pharmaceutical design.

U.S. Geological Survey Virginia and West Virginia Water Science Center

USGS Publications Warehouse

Jastram, John D.

2017-08-22

The U.S. Geological Survey (USGS) serves the Nation by providing reliable scientific information to describe and understand the Earth; minimize loss of life and property from natural disasters; manage water, biological, energy, and mineral resources; and enhance and protect our quality of life. In support of this mission, the USGS Virginia and West Virginia Water Science Center works in cooperation with many entities to provide reliable, impartial scientific information to resource managers, planners, and the public.

Synthetic approaches to the 2014 new drugs.

PubMed

Flick, Andrew C; Ding, Hong X; Leverett, Carolyn A; Kyne, Robert E; Liu, Kevin K-C; Fink, Sarah J; O'Donnell, Christopher J

2016-05-01

New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide insight into molecular recognition and also serve as leads for designing future new drugs. This annual review covers the synthesis of thirty-seven NCEs that were approved for the first time in 2014 and one drug which was approved in 2013 and was not covered in a previous edition of this review. Copyright © 2016 Elsevier Ltd. All rights reserved.

1995 Pacific Northwest Loads and Resources Study, Technical Appendix: Volume 1.

DOE Office of Scientific and Technical Information (OSTI.GOV)

United States. Bonneville Power Administration.

1995-12-01

The Pacific Northwest Loads and Resources Study (WhiteBook), is published annually by BPA, and establishes the planning basis for supplying electricity to customers. It serves a dual purpose. First, the White Book presents projections of regional and Federal system load and resource capabilities, along with relevant definitions and explanations. Second, the White Book serves as a benchmark for annual BPA determinations made pursuant to the 1981 regional power sales contracts. Specifically, BPA uses the, information in the White Book for determining the notice required when customers request to increase or decrease the amount of power purchased from BPA. Aside frommore » these purposes, the White Book is used for input to BPA`s resource planning process. The White Book compiles information obtained from several formalized resource planning reports and data submittals, including those from the Northwest Power Planning Council (Council) and the Pacific Northwest Utilities Conference Committee (PNUCC).« less

40 CFR 80.94 - Requirements for gasoline produced at foreign refineries.

Code of Federal Regulations, 2010 CFR

2010-07-01

... was not imported into the United States. (f) Load port independent sampling, testing and refinery... FRGAS to the United States; and (v) Determine the date and time the vessel departs the port serving the... departure of the vessel from the port serving the foreign refinery; (ii) Prepare a volume-weighted vessel...

40 CFR 80.94 - Requirements for gasoline produced at foreign refineries.

Code of Federal Regulations, 2011 CFR

2011-07-01

... was not imported into the United States. (f) Load port independent sampling, testing and refinery... FRGAS to the United States; and (v) Determine the date and time the vessel departs the port serving the... departure of the vessel from the port serving the foreign refinery; (ii) Prepare a volume-weighted vessel...

Decentralized Energy Management System for Networked Microgrids in Grid-connected and Islanded Modes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Zhaoyu; Chen, Bokan; Wang, Jianhui

This paper proposes a decentralized energy management system (EMS) for the coordinated operation of networked Microgirds (MGs) in a distribution system. In the grid-connected mode, the distribution network operator (DNO) and each MG are considered as distinct entities with individual objectives to minimize their own operation costs. It is assumed that both dispatchable and renewable energy source (RES)-based distributed generators (DGs) exist in the distribution network and the networked MGs. In order to coordinate the operation of all entities, we apply a decentralized bi-level algorithm to solve the problem with the first level to conduct negotiations among all entities andmore » the second level to update the non-converging penalties. In the islanded mode, the objective of each MG is to maintain a reliable power supply to its customers. In order to take into account the uncertainties of DG outputs and load consumption, we formulate the problems as two-stage stochastic programs. The first stage is to determine base generation setpoints based on the forecasts and the second stage is to adjust the generation outputs based on the realized scenarios. Case studies of a distribution system with networked MGs demonstrate the effectiveness of the proposed methodology in both grid-connected and islanded modes.« less

Customer and household matching: resolving entity identity in data warehouses

NASA Astrophysics Data System (ADS)

Berndt, Donald J.; Satterfield, Ronald K.

2000-04-01

The data preparation and cleansing tasks necessary to ensure high quality data are among the most difficult challenges faced in data warehousing and data mining projects. The extraction of source data, transformation into new forms, and loading into a data warehouse environment are all time consuming tasks that can be supported by methodologies and tools. This paper focuses on the problem of record linkage or entity matching, tasks that can be very important in providing high quality data. Merging two or more large databases into a single integrated system is a difficult problem in many industries, especially in the wake of acquisitions. For example, managing customer lists can be challenging when duplicate entries, data entry problems, and changing information conspire to make data quality an elusive target. Common tasks with regard to customer lists include customer matching to reduce duplicate entries and household matching to group customers. These often O(n2) problems can consume significant resources, both in computing infrastructure and human oversight, and the goal of high accuracy in the final integrated database can be difficult to assure. This paper distinguishes between attribute corruption and entity corruption, discussing the various impacts on quality. A metajoin operator is proposed and used to organize past and current entity matching techniques. Finally, a logistic regression approach to implementing the metajoin operator is discussed and illustrated with an example. The metajoin can be used to determine whether two records match, don't match, or require further evaluation by human experts. Properly implemented, the metajoin operator could allow the integration of individual databases with greater accuracy and lower cost.

Load theory of selective attention and cognitive control.

PubMed

Lavie, Nilli; Hirst, Aleksandra; de Fockert, Jan W; Viding, Essi

2004-09-01

A load theory of attention in which distractor rejection depends on the level and type of load involved in current processing was tested. A series of experiments demonstrates that whereas high perceptual load reduces distractor interference, working memory load or dual-task coordination load increases distractor interference. These findings suggest 2 selective attention mechanisms: a perceptual selection mechanism serving to reduce distractor perception in situations of high perceptual load that exhaust perceptual capacity in processing relevant stimuli and a cognitive control mechanism that reduces interference from perceived distractors as long as cognitive control functions are available to maintain current priorities (low cognitive load). This theory resolves the long-standing early versus late selection debate and clarifies the role of cognitive control in selective attention. ((c) 2004 APA, all rights reserved)

Biography of a technology: North America's power grid through the twentieth century

NASA Astrophysics Data System (ADS)

Cohn, Julie A.

North Americans are among the world's most intense consumers of electricity. The vast majority in the United States and Canada access power from a network of transmission lines that stretch from the East Coast to the West Coast and from Canada to the Mexican Baja. This network, known as the largest interconnected machine in the world, evolved during the first two thirds of the twentieth century. With the very first link-ups occurring at the end of the 1890s, a wide variety of public and private utilities extended power lines to reach markets, access and manage energy resources, balance loads, realize economies of scale, provide backup power, and achieve economic stability. In 1967, utility managers and the Bureau of Reclamation connected the expansive eastern and western power pools to create the North American grid. Unlike other power grids around the world, built by single, centrally controlled entities, this large technological system emerged as the result of multiple decisions across eighty-five years of development, and negotiations for control at the economic, political, and technological levels. This dissertation describes the process of building the North American grid and the paradoxes the resulting system represents. While the grid functions as a single machine moving electricity across the continent, it is owned by many independent entities. Smooth operations suggest that the grid is a unified system; however, it operates under shared management and divided authority. In addition, although a single power network seems the logical outcome of electrification, in fact it was assembled through aggregation, not planning. Interconnections intentionally increase the robustness of individual sub-networks, yet the system itself is fragile, as demonstrated by major cascading power outages. Finally, the transmission network facilitates increased use of energy resources and consumption of power, but at certain points in the past, it also served as a technology of conservation. While this project explores the history of how and why North America has a huge interconnected power system, it also offers insights into the challenges the grid poses for our energy future.

Coupling Dynamics Interlip Coordination in Lower Lip Load Compensation

ERIC Educational Resources Information Center

van Lieshout, Pascal; Neufeld, Chris

2014-01-01

Purpose: To study the effects of lower lip loading on lower and upper lip movements and their coordination to test predictions on coupling dynamics derived from studies in limb control. Method: Movement data were acquired using electromagnetic midsagittal articulography under 4 conditions: (a) without restrictions, serving as a baseline; (b) with…

75 FR 36381 - Office of Energy Policy and Innovation; Request for Comments Regarding Rates, Accounting and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-25

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. AD10-13-000] Office of... traditional asset categories, and also like load. The only electricity storage technology that has been widely... assets were constructed by vertically integrated load-serving utilities at retail ratepayer expense. In...

Effect of macronutrients and fiber on postprandial glycemic responses and meal glycemic index and glycemic load value determinations

USDA-ARS?s Scientific Manuscript database

Introduction: Meal or dietary glycemic index (GI) and glycemic load (GL) values from dietary questionnaires are calculated using GI values of individual foods and for GL after adjusting for serving size. Partially unaddressed is the potential confounding effect of different amounts and proportions o...

Interactions between muscle and the immune system during modified musculoskeletal loading

NASA Technical Reports Server (NTRS)

Tidball, James G.

2002-01-01

Interactions between the immune system and skeletal muscle may play a significant role in modulating the course of muscle injury and repair after modified musculoskeletal loading. Current evidence indicates that activation of the complement system is an early event during modified loading, which then leads to inflammatory cell invasion. However, the functions of those inflammatory cells are complex and they seem to be capable of promoting additional injury and repair. Recent findings implicate an early invading neutrophil population in increasing muscle damage that is detected by the presence of muscle membrane lesions. Macrophages that invade subsequently serve to remove cellular debris, and seem to promote repair. However, macrophages also have the ability to increase damage in muscle in which there is an impaired capacity to generate nitric oxide. In vivo and in vitro evidence indicates that muscle-derived nitric oxide can serve an important role in protecting muscle from membrane damage by invading inflammatory cells. Collectively, these findings indicate that the dynamic balance between inflammatory cells, the complement system, and muscle-derived free radicals can play important roles in the secondary damage of muscle during modified musculoskeletal loading.

Network-Friendly Gossiping

NASA Astrophysics Data System (ADS)

Serbu, Sabina; Rivière, Étienne; Felber, Pascal

The emergence of large-scale distributed applications based on many-to-many communication models, e.g., broadcast and decentralized group communication, has an important impact on the underlying layers, notably the Internet routing infrastructure. To make an effective use of network resources, protocols should both limit the stress (amount of messages) on each infrastructure entity like routers and links, and balance as much as possible the load in the network. Most protocols use application-level metrics such as delays to improve efficiency of content dissemination or routing, but the extend to which such application-centric optimizations help reduce and balance the load imposed to the infrastructure is unclear. In this paper, we elaborate on the design of such network-friendly protocols and associated metrics. More specifically, we investigate random-based gossip dissemination. We propose and evaluate different ways of making this representative protocol network-friendly while keeping its desirable properties (robustness and low delays). Simulations of the proposed methods using synthetic and real network topologies convey and compare their abilities to reduce and balance the load while keeping good performance.

Preparation, characterization and stability of curcumin-loaded zein-shellac composite colloidal particles.

PubMed

Sun, Cuixia; Xu, Chenqi; Mao, Like; Wang, Di; Yang, Jie; Gao, Yanxiang

2017-08-01

Curcumin-loaded zein-shellac composite particles were prepared by the antisolvent co-precipitation method. The encapsulation efficiency of curcumin was significantly improved from 82.7% in zein particles to 93.2% in zein-shellac complex particles. The result of differential scanning calorimetry suggested that curcumin in the polymeric matrix was in an amorphous state. Fourier transform infrared spectroscopy analysis revealed that curcumin had non-covalently interacted with zein and shellac, mainly through hydrogen bonding and hydrophobic interaction. Aggregates in irregular shapes, with large sizes, were found by atomic force microscopy, and conglutination, integration or fusion of different entities into network structures occurred at a high level of shellac. At the mass ratio of zein to shellac of 1:1, curcumin in the complex particles exhibited improved photochemical and thermal stability. Curcumin-loaded zein-shellac complex particles allowed the controlled release of curcumin in both PBS medium and simulated gastrointestinal fluids. Copyright © 2017 Elsevier Ltd. All rights reserved.

Exploring the relationship between planning and procurement in Western U.S. electric utilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carvallo Bodelon, Juan Pablo; Sanstad, Alan H.; Larsen, Peter H.

Integrated resource planning (IRP) is an important regulatory process used in many U.S. states to formulate and evaluate least-cost and risk-assessed portfolios to meet future load requirements for electric utilities. In principle, effective implementation of IRP seeks to assure regulators and the public that utility investment decisions, given uncertainty, are as cost-effective as possible. However, to date, there is no empirical assessment on the effectiveness of IRP implementation. In this analysis, we compare planning, procurement processes and actual decisions for a sample of twelve load serving entities (LSEs) across the Western U. S. from 2003-2014. The 2008/2009 recession provides amore » unique “stress test” to the planning process and offers an excellent opportunity to trace how procurement decisions responded to this largely unforeseen event. In aggregate, there is a general alignment between planned and procured supply-side capacity. However, there are significant differences in the choice of supply-side resources and type of ownership for individual LSEs. We develop case studies for three LSEs and find that subsequent plans differ significantly due to changes in the planning environment and that procurement decisions in some cases are impacted by factors that are not accounted for in the planning process. Our results reveal that a limited amount of information produced during the long-term planning process (e.g., forecasts, methods, and least cost/risk portfolios) are ultimately used during the procurement process, and that the latter process relies extensively on the most recent information available for decision making. These findings suggest that states' IRP rules and regulations mandating long-term planning horizons with the same analytical complexity throughout the planning period may not create useful information for the procurement process. The social value of a long-term planning process that departs from procurement and the balance between transparency and complexity of the planning and procurement processes is an open question.« less

Models of supply function equilibrium with applications to the electricity industry

NASA Astrophysics Data System (ADS)

Aromi, J. Daniel

Electricity market design requires tools that result in a better understanding of incentives of generators and consumers. Chapter 1 and 2 provide tools and applications of these tools to analyze incentive problems in electricity markets. In chapter 1, models of supply function equilibrium (SFE) with asymmetric bidders are studied. I prove the existence and uniqueness of equilibrium in an asymmetric SFE model. In addition, I propose a simple algorithm to calculate numerically the unique equilibrium. As an application, a model of investment decisions is considered that uses the asymmetric SFE as an input. In this model, firms can invest in different technologies, each characterized by distinct variable and fixed costs. In chapter 2, option contracts are introduced to a supply function equilibrium (SFE) model. The uniqueness of the equilibrium in the spot market is established. Comparative statics results on the effect of option contracts on the equilibrium price are presented. A multi-stage game where option contracts are traded before the spot market stage is considered. When contracts are optimally procured by a central authority, the selected profile of option contracts is such that the spot market price equals marginal cost for any load level resulting in a significant reduction in cost. If load serving entities (LSEs) are price takers, in equilibrium, there is no trade of option contracts. Even when LSEs have market power, the central authority's solution cannot be implemented in equilibrium. In chapter 3, we consider a game in which a buyer must repeatedly procure an input from a set of firms. In our model, the buyer is able to sign long term contracts that establish the likelihood with which the next period contract is awarded to an entrant or the incumbent. We find that the buyer finds it optimal to favor the incumbent, this generates more intense competition between suppliers. In a two period model we are able to completely characterize the optimal mechanism.

Design of a 500 lbf liquid oxygen and liquid methane rocket engine for suborbital flight

NASA Astrophysics Data System (ADS)

Trillo, Jesus Eduardo

Liquid methane (LCH4)is the most promising rocket fuel for our journey to Mars and other space entities. Compared to liquid hydrogen, the most common cryogenic fuel used today, methane is denser and can be stored at a more manageable temperature; leading to more affordable tanks and a lighter system. The most important advantage is it can be produced from local sources using in-situ resource utilization (ISRU) technology. This will allow the production of the fuel needed to come back to earth on the surface of Mars, or the space entity being explored, making the overall mission more cost effective by enabling larger usable mass. The major disadvantage methane has over hydrogen is it provides a lower specific impulse, or lower rocket performance. The UTEP Center for Space Exploration and Technology Research (cSETR) in partnership with the National Aeronautics and Space Administration (NASA) has been the leading research center for the advancement of Liquid Oxygen (LOX) and Liquid Methane (LCH4) propulsion technologies. Through this partnership, the CROME engine, a throattable 500 lbf LOX/LCH4 rocket engine, was designed and developed. The engine will serve as the main propulsion system for Daedalus, a suborbital demonstration vehicle being developed by the cSETR. The purpose of Daedalus mission and the engine is to fire in space under microgravity conditions to demonstrate its restartability. This thesis details the design process, decisions, and characteristics of the engine to serve as a complete design guide.

Measuring achievement goal motivation, mindsets and cognitive load: validation of three instruments' scores.

PubMed

Cook, David A; Castillo, Richmond M; Gas, Becca; Artino, Anthony R

2017-10-01

Measurement of motivation and cognitive load has potential value in health professions education. Our objective was to evaluate the validity of scores from Dweck's Implicit Theories of Intelligence Scale (ITIS), Elliot's Achievement Goal Questionnaire-Revised (AGQ-R) and Leppink's cognitive load index (CLI). This was a validity study evaluating internal structure using reliability and factor analysis, and relationships with other variables using the multitrait-multimethod matrix. Two hundred and thirty-two secondary school students participated in a medical simulation-based training activity at an academic medical center. Pre-activity ITIS (implicit theory [mindset] domains: incremental, entity) and AGQ-R (achievement goal domains: mastery-approach, mastery-avoidance, performance-approach, performance-avoidance), post-activity CLI (cognitive load domains: intrinsic, extrinsic, germane) and task persistence (self-directed repetitions on a laparoscopic surgery task) were measured. Internal consistency reliability (Cronbach's alpha) was > 0.70 for all domain scores except AGQ-R performance-avoidance (alpha 0.68) and CLI extrinsic load (alpha 0.64). Confirmatory factor analysis of ITIS and CLI scores demonstrated acceptable model fit. Confirmatory factor analysis of AGQ-R scores demonstrated borderline fit, and exploratory factor analysis suggested a three-domain model for achievement goals (mastery-approach, performance and avoidance). Correlations among scores from conceptually-related domains generally aligned with expectations, as follows: ITIS incremental and entity, r = -0.52; AGQ-R mastery-avoidance and performance-avoidance, r = 0.71; mastery-approach and performance-approach, r = 0.55; performance-approach and performance-avoidance, r = 0.43; mastery-approach and mastery-avoidance, r = 0.36; CLI germane and extrinsic, r = -0.35; ITIS incremental and AGQ-R mastery-approach, r = 0.34; ITIS incremental and CLI germane, r = 0.44; AGQ-R mastery-approach and CLI germane, r = 0.48 (all p < 0.001). We found no correlation between the number of task repetitions (i.e. persistence) and mastery-approach scores, r = -0.01. ITIS and CLI scores had appropriate internal structures and relationships with other variables. AGQ-R scores fit a three-factor (not four-factor) model that collapsed avoidance into one domain, although relationships of other variables with the original four domain scores generally aligned with expectations. Mastery goals are positively correlated with germane cognitive load. © 2017 John Wiley & Sons Ltd and The Association for the Study of Medical Education.

BioCreative V CDR task corpus: a resource for chemical disease relation extraction.

PubMed

Li, Jiao; Sun, Yueping; Johnson, Robin J; Sciaky, Daniela; Wei, Chih-Hsuan; Leaman, Robert; Davis, Allan Peter; Mattingly, Carolyn J; Wiegers, Thomas C; Lu, Zhiyong

2016-01-01

Community-run, formal evaluations and manually annotated text corpora are critically important for advancing biomedical text-mining research. Recently in BioCreative V, a new challenge was organized for the tasks of disease named entity recognition (DNER) and chemical-induced disease (CID) relation extraction. Given the nature of both tasks, a test collection is required to contain both disease/chemical annotations and relation annotations in the same set of articles. Despite previous efforts in biomedical corpus construction, none was found to be sufficient for the task. Thus, we developed our own corpus called BC5CDR during the challenge by inviting a team of Medical Subject Headings (MeSH) indexers for disease/chemical entity annotation and Comparative Toxicogenomics Database (CTD) curators for CID relation annotation. To ensure high annotation quality and productivity, detailed annotation guidelines and automatic annotation tools were provided. The resulting BC5CDR corpus consists of 1500 PubMed articles with 4409 annotated chemicals, 5818 diseases and 3116 chemical-disease interactions. Each entity annotation includes both the mention text spans and normalized concept identifiers, using MeSH as the controlled vocabulary. To ensure accuracy, the entities were first captured independently by two annotators followed by a consensus annotation: The average inter-annotator agreement (IAA) scores were 87.49% and 96.05% for the disease and chemicals, respectively, in the test set according to the Jaccard similarity coefficient. Our corpus was successfully used for the BioCreative V challenge tasks and should serve as a valuable resource for the text-mining research community.Database URL: http://www.biocreative.org/tasks/biocreative-v/track-3-cdr/. Published by Oxford University Press 2016. This work is written by US Government employees and is in the public domain in the United States.

MOAB : a mesh-oriented database.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tautges, Timothy James; Ernst, Corey; Stimpson, Clint

A finite element mesh is used to decompose a continuous domain into a discretized representation. The finite element method solves PDEs on this mesh by modeling complex functions as a set of simple basis functions with coefficients at mesh vertices and prescribed continuity between elements. The mesh is one of the fundamental types of data linking the various tools in the FEA process (mesh generation, analysis, visualization, etc.). Thus, the representation of mesh data and operations on those data play a very important role in FEA-based simulations. MOAB is a component for representing and evaluating mesh data. MOAB can storemore » structured and unstructured mesh, consisting of elements in the finite element 'zoo'. The functional interface to MOAB is simple yet powerful, allowing the representation of many types of metadata commonly found on the mesh. MOAB is optimized for efficiency in space and time, based on access to mesh in chunks rather than through individual entities, while also versatile enough to support individual entity access. The MOAB data model consists of a mesh interface instance, mesh entities (vertices and elements), sets, and tags. Entities are addressed through handles rather than pointers, to allow the underlying representation of an entity to change without changing the handle to that entity. Sets are arbitrary groupings of mesh entities and other sets. Sets also support parent/child relationships as a relation distinct from sets containing other sets. The directed-graph provided by set parent/child relationships is useful for modeling topological relations from a geometric model or other metadata. Tags are named data which can be assigned to the mesh as a whole, individual entities, or sets. Tags are a mechanism for attaching data to individual entities and sets are a mechanism for describing relations between entities; the combination of these two mechanisms is a powerful yet simple interface for representing metadata or application-specific data. For example, sets and tags can be used together to describe geometric topology, boundary condition, and inter-processor interface groupings in a mesh. MOAB is used in several ways in various applications. MOAB serves as the underlying mesh data representation in the VERDE mesh verification code. MOAB can also be used as a mesh input mechanism, using mesh readers included with MOAB, or as a translator between mesh formats, using readers and writers included with MOAB. The remainder of this report is organized as follows. Section 2, 'Getting Started', provides a few simple examples of using MOAB to perform simple tasks on a mesh. Section 3 discusses the MOAB data model in more detail, including some aspects of the implementation. Section 4 summarizes the MOAB function API. Section 5 describes some of the tools included with MOAB, and the implementation of mesh readers/writers for MOAB. Section 6 contains a brief description of MOAB's relation to the TSTT mesh interface. Section 7 gives a conclusion and future plans for MOAB development. Section 8 gives references cited in this report. A reference description of the full MOAB API is contained in Section 9.« less

Phenex: ontological annotation of phenotypic diversity.

PubMed

Balhoff, James P; Dahdul, Wasila M; Kothari, Cartik R; Lapp, Hilmar; Lundberg, John G; Mabee, Paula; Midford, Peter E; Westerfield, Monte; Vision, Todd J

2010-05-05

Phenotypic differences among species have long been systematically itemized and described by biologists in the process of investigating phylogenetic relationships and trait evolution. Traditionally, these descriptions have been expressed in natural language within the context of individual journal publications or monographs. As such, this rich store of phenotype data has been largely unavailable for statistical and computational comparisons across studies or integration with other biological knowledge. Here we describe Phenex, a platform-independent desktop application designed to facilitate efficient and consistent annotation of phenotypic similarities and differences using Entity-Quality syntax, drawing on terms from community ontologies for anatomical entities, phenotypic qualities, and taxonomic names. Phenex can be configured to load only those ontologies pertinent to a taxonomic group of interest. The graphical user interface was optimized for evolutionary biologists accustomed to working with lists of taxa, characters, character states, and character-by-taxon matrices. Annotation of phenotypic data using ontologies and globally unique taxonomic identifiers will allow biologists to integrate phenotypic data from different organisms and studies, leveraging decades of work in systematics and comparative morphology.

Amyloid and the origin of life: self-replicating catalytic amyloids as prebiotic informational and protometabolic entities.

PubMed

Maury, Carl Peter J

2018-05-01

A crucial stage in the origin of life was the emergence of the first molecular entity that was able to replicate, transmit information, and evolve on the early Earth. The amyloid world hypothesis posits that in the pre-RNA era, information processing was based on catalytic amyloids. The self-assembly of short peptides into β-sheet amyloid conformers leads to extraordinary structural stability and novel multifunctionality that cannot be achieved by the corresponding nonaggregated peptides. The new functions include self-replication, catalytic activities, and information transfer. The environmentally sensitive template-assisted replication cycles generate a variety of amyloid polymorphs on which evolutive forces can act, and the fibrillar assemblies can serve as scaffolds for the amyloids themselves and for ribonucleotides proteins and lipids. The role of amyloid in the putative transition process from an amyloid world to an amyloid-RNA-protein world is not limited to scaffolding and protection: the interactions between amyloid, RNA, and protein are both complex and cooperative, and the amyloid assemblages can function as protometabolic entities catalyzing the formation of simple metabolite precursors. The emergence of a pristine amyloid-based in-put sensitive, chiroselective, and error correcting information-processing system, and the evolvement of mutualistic networks were, arguably, of essential importance in the dynamic processes that led to increased complexity, organization, compartmentalization, and, eventually, the origin of life.

Excipients and their role in approved injectable products: current usage and future directions.

PubMed

Nema, Sandeep; Brendel, Ronald J

2011-01-01

This review article is a current survey of excipients used in approved injectable products. Information provided includes concentration ranges, function, frequency of use, and role in dosage form. This article is an update of a paper published more than a decade ago (reference 11). Since then many new products have been approved. Safety concerning excipients has evolved as the scientific community continues to learn about their usage. New excipients are being used in early phases of clinical trials to support novel therapeutic entities like RNAi, aptamers, anti-sense, fusion proteins, monoclonal antibodies, and variant scaffolds. Because these excipients are not inert, various pharmacopoeias are responding with monographs or informational chapters addressing excipient functionality. The final sections of this article discuss new excipients, serving specific needs that traditional excipients are unable to provide and for which safety studies are necessary to support a novel excipient for marketing applications. Excipients are added to parenteral dosage forms to serve a variety of functions including stabilization and as vehicles. This review article is a survey of excipients used in approved injectable products. Information provided includes excipient concentrations, functional roles, and frequency of use. This article is an update of an article originally published over a decade ago. Since then new products have been approved and safety concerns have evolved as the scientific community has learned about the usage of excipients. In addition, new excipients are being used in early phases of clinical trials to support novel therapeutic entities such as RNAi, aptamers, anti-sense, fusion proteins, monoclonal antibodies, and variant scaffolds. Because these excipients are not inert, various pharmacopoeias are responding with monographs or informational chapters addressing excipient functionality. The final sections of this article discuss new excipients, serving specific needs that traditional excipients are unable to provide and for which safety studies are necessary to support a novel excipient for marketing applications.

DWARF – a data warehouse system for analyzing protein families

PubMed Central

Fischer, Markus; Thai, Quan K; Grieb, Melanie; Pleiss, Jürgen

2006-01-01

Background The emerging field of integrative bioinformatics provides the tools to organize and systematically analyze vast amounts of highly diverse biological data and thus allows to gain a novel understanding of complex biological systems. The data warehouse DWARF applies integrative bioinformatics approaches to the analysis of large protein families. Description The data warehouse system DWARF integrates data on sequence, structure, and functional annotation for protein fold families. The underlying relational data model consists of three major sections representing entities related to the protein (biochemical function, source organism, classification to homologous families and superfamilies), the protein sequence (position-specific annotation, mutant information), and the protein structure (secondary structure information, superimposed tertiary structure). Tools for extracting, transforming and loading data from public available resources (ExPDB, GenBank, DSSP) are provided to populate the database. The data can be accessed by an interface for searching and browsing, and by analysis tools that operate on annotation, sequence, or structure. We applied DWARF to the family of α/β-hydrolases to host the Lipase Engineering database. Release 2.3 contains 6138 sequences and 167 experimentally determined protein structures, which are assigned to 37 superfamilies 103 homologous families. Conclusion DWARF has been designed for constructing databases of large structurally related protein families and for evaluating their sequence-structure-function relationships by a systematic analysis of sequence, structure and functional annotation. It has been applied to predict biochemical properties from sequence, and serves as a valuable tool for protein engineering. PMID:17094801

Reaction Kinetic Model of Dilute Acid-Catalyzed Hemicellulose Hydrolysis of Corn Stover under High-Solid Conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shi, Suan; Guan, Wenjian; Kang, Li

High solid conditions are desirable in pretreatment of lignocellulosic biomass. An advanced dilute-acid pretreatment reactor has been developed at National Renewable Energy Laboratory (NREL). It is a continuous auger-driven reactor that can be operated with high-solid charge at high temperature and with short residence time resulting high productivity and high sugar concentration. Here, we investigated the kinetics of the reactions associated with dilute-acid pretreatment of corn stover, covering the reaction conditions of the NREL reactor operation: 155-185 C, 1-2 wt% sulfuric acid concentration, and 1:2 solid to liquid ratio. The experimental data were fitted to a first-order biphasic model whichmore » assumes that xylan is comprised of two different fragments: fast and slow reacting fractions. Due to the high solid loading condition, significant amount of xylose oligomers was observed during the pretreatment. We also included the oligomers as an intermediate entity in the kinetic model. The effect of acid concentration was incorporated into the pre-exponential factor of Arrhenius equation. The kinetic model with bestfit kinetic parameters has shown good agreement with experimental data. The kinetic parameter values of the proposed model were noticeably different from those previously reported. The activation energies of xylan hydrolysis are lower and the acid exponents are higher than the average of literature values. The proposed model can serve as a useful tool for design and operation of pretreatment system pertaining to corn stover.« less

Reaction Kinetic Model of Dilute Acid-Catalyzed Hemicellulose Hydrolysis of Corn Stover under High-Solid Conditions

DOE PAGES

Shi, Suan; Guan, Wenjian; Kang, Li; ...

2017-09-13

High solid conditions are desirable in pretreatment of lignocellulosic biomass. An advanced dilute-acid pretreatment reactor has been developed at National Renewable Energy Laboratory (NREL). It is a continuous auger-driven reactor that can be operated with high-solid charge at high temperature and with short residence time resulting high productivity and high sugar concentration. Here, we investigated the kinetics of the reactions associated with dilute-acid pretreatment of corn stover, covering the reaction conditions of the NREL reactor operation: 155-185 C, 1-2 wt% sulfuric acid concentration, and 1:2 solid to liquid ratio. The experimental data were fitted to a first-order biphasic model whichmore » assumes that xylan is comprised of two different fragments: fast and slow reacting fractions. Due to the high solid loading condition, significant amount of xylose oligomers was observed during the pretreatment. We also included the oligomers as an intermediate entity in the kinetic model. The effect of acid concentration was incorporated into the pre-exponential factor of Arrhenius equation. The kinetic model with bestfit kinetic parameters has shown good agreement with experimental data. The kinetic parameter values of the proposed model were noticeably different from those previously reported. The activation energies of xylan hydrolysis are lower and the acid exponents are higher than the average of literature values. The proposed model can serve as a useful tool for design and operation of pretreatment system pertaining to corn stover.« less

Academic Crossover Study, University of Hawaii Community Colleges, Fall 1999.

ERIC Educational Resources Information Center

Hawaii Univ., Honolulu. Office of the Chancellor for Community Colleges.

The academic crossover study was developed to answer two questions: (1) What is the course-taking pattern of the different groups of academic majors? (e.g. what is proportion of academic load taken outside the major); and (2) What is the client-serving pattern of the different subject disciplines? (e.g. what are the groups of students served by…

Space Generic Open Avionics Architecture (SGOAA): Overview

NASA Technical Reports Server (NTRS)

Wray, Richard B.; Stovall, John R.

1992-01-01

A space generic open avionics architecture created for NASA is described. It will serve as the basis for entities in spacecraft core avionics, capable of being tailored by NASA for future space program avionics ranging from small vehicles such as Moon ascent/descent vehicles to large ones such as Mars transfer vehicles or orbiting stations. The standard consists of: (1) a system architecture; (2) a generic processing hardware architecture; (3) a six class architecture interface model; (4) a system services functional subsystem architectural model; and (5) an operations control functional subsystem architectural model.

Best Practices for Management of Biocontaminated Waste ...

EPA Pesticide Factsheets

Report The purpose of these best practices is to provide federal, state, territorial, and local waste management entities information on techniques and methodologies that have the potential to improve the handling and management of biocontaminated waste streams after a biological agent incident. These best practices are intended to be general in nature serving as a resource to a variety of biological agents in a variety of situations; however, these best practices also present a specific homeland security scenario – a biological attack with Bacillus anthracis (B. anthracis) – to help illustrate specific waste management considerations.

Mindstorms robots and the application of cognitive load theory in introductory programming

NASA Astrophysics Data System (ADS)

Mason, Raina; Cooper, Graham

2013-12-01

This paper reports on a series of introductory programming workshops, initially targeting female high school students, which utilised Lego Mindstorms robots. Cognitive load theory (CLT) was applied to the instructional design of the workshops, and a controlled experiment was also conducted investigating aspects of the interface. Results indicated that a truncated interface led to better learning by novice programmers as measured by test performance by participants, as well as enhanced shifts in self-efficacy and lowered perception of difficulty. There was also a transfer effect to another programming environment (Alice). It is argued that the results indicate that for novice programmers, the mere presence on-screen of additional (redundant) entities acts as a form of tacit distraction, thus impeding learning. The utility of CLT to analyse, design and deliver aspects of computer programming environments and instructional materials is discussed.

Omega 3 Chia seed loading as a means of carbohydrate loading.

PubMed

Illian, Travis G; Casey, Jason C; Bishop, Phillip A

2011-01-01

The purpose of this study was to determine if Omega 3 Chia seed loading is a viable option for enhancing sports performance in events lasting >90 minutes and allow athletes to decrease their dietary intake of sugar while increasing their intake of Omega 3 fatty acids. It has been well documented that a high dietary carbohydrate (CHO) intake for several days before competition is known to increase muscle glycogen stores resulting in performance improvements in events lasting >90 minutes. This study compared performance testing results between 2 different CHO-loading treatments. The traditional CHO-loading treatment served as the control (100% cals from Gatorade). The Omega 3 Chia drink (50% of calories from Greens Plus Omega 3 Chia seeds, 50% Gatorade) served as the Omega 3 Chia loading drink. Both CHO-loading treatments were based on the subject's body weight and were thus isocaloric. Six highly trained male subjects V(O2)max 47.8-84.2 ml · kg(-1); mean (SD) of V(O2)max 70.3 ml · kg(-1) (13.3) performed a 1-hour run at ∼65% of their V(O2)max on a treadmill, followed by a 10k time trial on a track. There were 2 trials in a crossover counterbalanced repeated-measures design with a 2-week washout between testing sessions to allow the participants to recover from the intense exercise and any effects of the treatment. There was no statistical difference (p = 0.83) between Omega 3 Chia loading (mean 10k time = 37 minutes 49 seconds) and CHO loading (mean = 37 minutes 43 seconds). Under our conditions, Omega 3 Chia loading appears a viable option for enhancing performance for endurance events lasting >90 minutes and allows athletes to decrease their dietary intake of sugar while increasing their intake of Omega 3 fatty acids but offered no performance advantages.

User perspectives on the usability of a regional health information exchange

PubMed Central

Ho, Yun-Xian; Cala, Cather Marie; Blakemore, Dana; Chen, Qingxia; Frisse, Mark E; Johnson, Kevin B

2011-01-01

Objective We assessed the usability of a health information exchange (HIE) in a densely populated metropolitan region. This grant-funded HIE had been deployed rapidly to address the imminent needs of the patient population and the need to draw wider participation from regional entities. Design We conducted a cross-sectional survey of individuals given access to the HIE at participating organizations and examined some of the usability and usage factors related to the technology acceptance model. Measurements We probed user perceptions using the Questionnaire for User Interaction Satisfaction, an author-generated Trust scale, and user characteristic questions (eg, age, weekly system usage time). Results Overall, users viewed the system favorably (ratings for all usability items were greater than neutral (one-sample Wilcoxon test, p<0.0014, Bonferroni-corrected for 35 tests). System usage was regressed on usability, trust, and demographic and user characteristic factors. Three usability factors were positively predictive of system usage: overall reactions (p<0 0.01), learning (p<0.05), and system functionality (p<0.01). Although trust is an important component in collaborative relationships, we did not find that user trust of other participating healthcare entities was significantly predictive of usage. An analysis of respondents' comments revealed ways to improve the HIE. Conclusion We used a rapid deployment model to develop an HIE and found that perceptions of system usability were positive. We also found that system usage was predicted well by some aspects of usability. Results from this study suggest that a rapid development approach may serve as a viable model for developing usable HIEs serving communities with limited resources. PMID:21622933

Characterization of Antibiotic-Loaded Alginate-Osa Starch Microbeads Produced by Ionotropic Pregelation

PubMed Central

Fontes, Gizele Cardoso; Calado, Verônica Maria Araújo; Rossi, Alexandre Malta; da Rocha-Leão, Maria Helena Miguez

2013-01-01

The aim of this study was to characterize the penicillin-loaded microbeads composed of alginate and octenyl succinic anhydride (OSA) starch prepared by ionotropic pregelation with calcium chloride and to evaluate their in vitro drug delivery profile. The beads were characterized by size, scanning electron microscopy (SEM), zeta potential, swelling behavior, and degree of erosion. Also, the possible interaction between penicillin and biopolymers was investigated by differential scanning calorimetry (DSC), powder X-ray diffraction (XRD), and Fourier transform infrared (FTIR) analysis. The SEM micrograph results indicated a homogeneous drug distribution in the matrix. Also, based on thermal analyses (TGA/DSC), interactions were detected between microbead components. Although FTIR spectra of penicillin-loaded microbeads did not reveal the formation of new chemical entities, they confirmed the chemical drug stability. XRD patterns showed that the incorporated crystalline structure of penicillin did not significantly alter the primarily amorphous polymeric network. In addition, the results confirmed a prolonged penicillin delivery system profile. These results imply that alginate and OSA starch beads can be used as a suitable controlled-release carrier for penicillin. PMID:23862146

Hydromechanical drilling device

DOEpatents

Summers, David A.

1978-01-01

A hydromechanical drilling tool which combines a high pressure water jet drill with a conventional roller cone type of drilling bit. The high pressure jet serves as a tap drill for cutting a relatively small diameter hole in advance of the conventional bit. Auxiliary laterally projecting jets also serve to partially cut rock and to remove debris from in front of the bit teeth thereby reducing significantly the thrust loading for driving the bit.

Municipal solid waste flow and waste generation characteristics in an urban--rural fringe area in Thailand.

PubMed

Hiramatsu, Ai; Hara, Yuji; Sekiyama, Makiko; Honda, Ryo; Chiemchaisri, Chart

2009-12-01

In the urban-rural fringe of the Bangkok Metropolitan Region, rapid urbanization is creating a land-use mixture of agricultural fields and residential areas. To develop appropriate policies to enhance recycling of municipal solid waste (MSW), current MSW management was investigated in the oboto (local administrative district) of Bang Maenang in Nonthaburi Province, adjoining Bangkok. The authors conducted a structural interview survey with waste-related organizations and local residents, analysed household waste generation, and performed global positioning system (GPS) tracking of municipal garbage trucks. It was found that MSW was collected and treated by local government, private-sector entities, and the local community separately. Lack of integrated management of these entities complicated waste flow in the study area, and some residences were not served by MSW collection. Organic waste, such as kitchen garbage and yard waste, accounted for a large proportion of waste generation but was underutilized. Through GPS/GIS analysis, the waste collection rate of the generated waste amount was estimated to be 45.5- 51.1% of total generation.

77 FR 54663 - Administrative Simplification: Adoption of a Standard for a Unique Health Plan Identifier...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-05

...This final rule adopts the standard for a national unique health plan identifier (HPID) and establishes requirements for the implementation of the HPID. In addition, it adopts a data element that will serve as an other entity identifier (OEID), or an identifier for entities that are not health plans, health care providers, or individuals, but that need to be identified in standard transactions. This final rule also specifies the circumstances under which an organization covered health care provider must require certain noncovered individual health care providers who are prescribers to obtain and disclose a National Provider Identifier (NPI). Lastly, this final rule changes the compliance date for the International Classification of Diseases, 10th Revision, Clinical Modification (ICD- 10-CM) for diagnosis coding, including the Official ICD-10-CM Guidelines for Coding and Reporting, and the International Classification of Diseases, 10th Revision, Procedure Coding System (ICD-10-PCS) for inpatient hospital procedure coding, including the Official ICD-10-PCS Guidelines for Coding and Reporting, from October 1, 2013 to October 1, 2014.

ParaBTM: A Parallel Processing Framework for Biomedical Text Mining on Supercomputers.

PubMed

Xing, Yuting; Wu, Chengkun; Yang, Xi; Wang, Wei; Zhu, En; Yin, Jianping

2018-04-27

A prevailing way of extracting valuable information from biomedical literature is to apply text mining methods on unstructured texts. However, the massive amount of literature that needs to be analyzed poses a big data challenge to the processing efficiency of text mining. In this paper, we address this challenge by introducing parallel processing on a supercomputer. We developed paraBTM, a runnable framework that enables parallel text mining on the Tianhe-2 supercomputer. It employs a low-cost yet effective load balancing strategy to maximize the efficiency of parallel processing. We evaluated the performance of paraBTM on several datasets, utilizing three types of named entity recognition tasks as demonstration. Results show that, in most cases, the processing efficiency can be greatly improved with parallel processing, and the proposed load balancing strategy is simple and effective. In addition, our framework can be readily applied to other tasks of biomedical text mining besides NER.

Enhanced object-based tracking algorithm for convective rain storms and cells

NASA Astrophysics Data System (ADS)

Muñoz, Carlos; Wang, Li-Pen; Willems, Patrick

2018-03-01

This paper proposes a new object-based storm tracking algorithm, based upon TITAN (Thunderstorm Identification, Tracking, Analysis and Nowcasting). TITAN is a widely-used convective storm tracking algorithm but has limitations in handling small-scale yet high-intensity storm entities due to its single-threshold identification approach. It also has difficulties to effectively track fast-moving storms because of the employed matching approach that largely relies on the overlapping areas between successive storm entities. To address these deficiencies, a number of modifications are proposed and tested in this paper. These include a two-stage multi-threshold storm identification, a new formulation for characterizing storm's physical features, and an enhanced matching technique in synergy with an optical-flow storm field tracker, as well as, according to these modifications, a more complex merging and splitting scheme. High-resolution (5-min and 529-m) radar reflectivity data for 18 storm events over Belgium are used to calibrate and evaluate the algorithm. The performance of the proposed algorithm is compared with that of the original TITAN. The results suggest that the proposed algorithm can better isolate and match convective rainfall entities, as well as to provide more reliable and detailed motion estimates. Furthermore, the improvement is found to be more significant for higher rainfall intensities. The new algorithm has the potential to serve as a basis for further applications, such as storm nowcasting and long-term stochastic spatial and temporal rainfall generation.

The "for-benefit" academic medical center: a solution for survival.

PubMed

Sabeti, Heerad; Kahn, Marc J; Sachs, Benjamin P

2015-05-01

Academic medical centers (AMCs) are the backbone of the U.S. health care system. They provide a disproportionate share of charity care and serve as a training ground for future physicians. Yet, AMCs face profound economic challenges, from changes in funding to changes in the health care market. To survive, many AMCs will need to form integrated health systems, a process expected to cost tens, if not hundreds, of millions of dollars. Nearly all AMCs are structured as not-for- profit entities, which places restrictions on their ability to forge partnerships, pursue joint ventures, and access private capital, often essential elements for forming such integrated systems. An alternative model known as the "for-benefit" corporation can allow AMCs to retain their important social mission and the other advantages of their not-for-profit status while allowing them flexibility and access to both investment and philanthropic capital. To pursue the for-benefit pathway, AMCs have two options-either they could work within the constraints of existing laws to restructure themselves as for-benefit entities, or they could create, under federal law, a new for-benefit AMC model, allowing for the orderly conversion of not-for-profit AMCs. Essential components of a for-benefit AMC include a social purpose, access to multiple forms of capital, the use of earnings to support its purpose, transparency, aligned compensation, and tax exemptions. Restructuring an AMC as a for-benefit entity enables it to both advance shareholder value and further the public good.

"If we're going to change things, it has to be systemic:" systems change in children's mental health.

PubMed

Hodges, Sharon; Ferreira, Kathleen; Israel, Nathaniel

2012-06-01

Communities that undertake systems change in accordance with the system of care philosophy commit to creating new systems entities for children and adolescents with serious emotional disturbance. These new entities are values-based, voluntary, and cross-agency alliances that include formal child-serving entities, youth, and families. Describing the scope and intent of one such implementation of systems of care, a mental health administrator commented, "If we're going to change things, it has to be systemic" (B. Baxter, personal communication, December 2, 2005). This paper explores the concept of "systemic" in the context of systems of care. Systems theory is used to understand strategies of purposeful systems change undertaken by stakeholders in established system of care communities. The paper presents a conceptual model of systems change for systems of care that is grounded in data from a national study of system of care implementation (Research and Training Center for Children's Mental Health in Case Studies of system implementation: Holistic approaches to studying community-based systems of care: Study 2, University of South Florida, Louis de la Parte Florida Mental Health Institute, Research and Training Center for Children's Mental Health, Tampa, FL, 2004). The model is based on Soft Systems Methodology, an application of systems theory developed to facilitate practical action around systems change in human systems (Checkland in Systems thinking, systems practice, Wiley, Chichester, 1999). The implications of these findings to real world actions associated with systems change in systems of care are discussed.

Combined Loadings and Cross-Dimensional Loadings Timeliness of Presentation of Financial Statements of Local Government

NASA Astrophysics Data System (ADS)

Muda, I.; Dharsuky, A.; Siregar, H. S.; Sadalia, I.

2017-03-01

This study examines the pattern of readiness dimensional accuracy of financial statements of local government in North Sumatra with a routine pattern of two (2) months after the fiscal year ends and patterns of at least 3 (three) months after the fiscal year ends. This type of research is explanatory survey with quantitative methods. The population and the sample used is of local government officials serving local government financial reports. Combined Analysis And Cross-Loadings Loadings are used with statistical tools WarpPLS. The results showed that there was a pattern that varies above dimensional accuracy of the financial statements of local government in North Sumatra.

Research on a Method of Geographical Information Service Load Balancing

NASA Astrophysics Data System (ADS)

Li, Heyuan; Li, Yongxing; Xue, Zhiyong; Feng, Tao

2018-05-01

With the development of geographical information service technologies, how to achieve the intelligent scheduling and high concurrent access of geographical information service resources based on load balancing is a focal point of current study. This paper presents an algorithm of dynamic load balancing. In the algorithm, types of geographical information service are matched with the corresponding server group, then the RED algorithm is combined with the method of double threshold effectively to judge the load state of serve node, finally the service is scheduled based on weighted probabilistic in a certain period. At the last, an experiment system is built based on cluster server, which proves the effectiveness of the method presented in this paper.

An Economic Evalution of Demand-side Energy Storage Systems by using a Multi-agent based Electricity Market

NASA Astrophysics Data System (ADS)

Furusawa, Ken; Sugihara, Hideharu; Tsuji, Kiichiro

Opened wholesale electric power market in April 2005, deregulation of electric power industry in Japan has faced a new competitive environment. In the new environment, Independent Power Producer (: IPP), Power Producer and Supplier (: PPS), Load Service Entity (: LSE) and electric utility can trade electric energy through both bilateral contracts and single-price auction at the electricity market. In general, the market clearing price (: MCP) is largely changed by amount of total load demand in the market. The influence may cause price spike, and consequently the volatility of MCP will make LSEs and their customers to face a risk of revenue and cost. DSM is attracted as a means of load leveling, and has effect on decreasing MCP at peak load period. Introducing Energy Storage systems (: ES) is one of DSM in order to change demand profile at customer-side. In case that customers decrease their own demand at jumped MCP, a bidding strategy of generating companies may be changed their strategy. As a result, MCP is changed through such complex mechanism. In this paper the authors evaluate MCP by multi-agent. It is considered that customer-side ES has an effect on MCP fluctuation. Through numerical examples, this paper evaluates the influence on MCP by controlling customer-side ES corresponding to variation of MCP.

7 CFR 1710.152 - Primary support documents.

Code of Federal Regulations, 2010 CFR

2010-01-01

... capital investments required to serve a borrower's planned new loads, improve service reliability and... manager to guide the system toward its financial goals. The forecast submitted in support of a loan...

Effects of the racket polar moment of inertia on dominant upper limb joint moments during tennis serve.

PubMed

Rogowski, Isabelle; Creveaux, Thomas; Chèze, Laurence; Macé, Pierre; Dumas, Raphaël

2014-01-01

This study examined the effect of the polar moment of inertia of a tennis racket on upper limb loading in the serve. Eight amateur competition tennis players performed two sets of 10 serves using two rackets identical in mass, position of center of mass and moments of inertia other than the polar moment of inertia (0.00152 vs 0.00197 kg.m2). An eight-camera motion analysis system collected the 3D trajectories of 16 markers, located on the thorax, upper limbs and racket, from which shoulder, elbow and wrist net joint moments and powers were computed using inverse dynamics. During the cocking phase, increased racket polar moment of inertia was associated with significant increases in the peak shoulder extension and abduction moments, as well the peak elbow extension, valgus and supination moments. During the forward swing phase, peak wrist extension and radial deviation moments significantly increased with polar moment of inertia. During the follow-through phase, the peak shoulder adduction, elbow pronation and wrist external rotation moments displayed a significant inverse relationship with polar moment of inertia. During the forward swing, the magnitudes of negative joint power at the elbow and wrist were significantly larger when players served using the racket with a higher polar moment of inertia. Although a larger polar of inertia allows players to better tolerate off-center impacts, it also appears to place additional loads on the upper extremity when serving and may therefore increase injury risk in tennis players.

Operational concepts and implementation strategies for the design configuration management process.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trauth, Sharon Lee

2007-05-01

This report describes operational concepts and implementation strategies for the Design Configuration Management Process (DCMP). It presents a process-based systems engineering model for the successful configuration management of the products generated during the operation of the design organization as a business entity. The DCMP model focuses on Pro/E and associated activities and information. It can serve as the framework for interconnecting all essential aspects of the product design business. A design operation scenario offers a sense of how to do business at a time when DCMP is second nature within the design organization.

MRI appearance of massive renal replacement lipomatosis in the absence of renal calculus disease

PubMed Central

Fitzgerald, E; Melamed, J; Taneja, S S; Rosenkrantz, A B

2011-01-01

Renal replacement lipomatosis is a rare benign entity in which extensive fibrofatty proliferation of the renal sinus is associated with marked renal atrophy. In this report, we present a case of massive renal replacement lipomatosis demonstrated on MRI. The presentation was atypical given an absence of associated renal calculus disease, and an initial CT scan was interpreted as suspicious for a liposarcoma. The differential diagnosis and key MRI findings that served to establish this specific diagnosis are reviewed. Histopathological correlation is also presented, as the patient underwent nephroureterectomy. PMID:21257835

Computerized commodity management system in Thailand and Brazil.

PubMed

1984-01-01

Thailand's National Family Planning Program is testing a computerized contraceptive commodity reporting management in 4 provinces with 104 National Family Planning Program (NFPP) reporting entities. Staff in the Brazilian Association of Family Planning Entities (ABEPF) and CPAIMC, a major family planning service agency, have been trained in the use of a computerized commodity distribution management system and are ready to initiate test use. The systems were designed in response to specific commodity management needs of the concerned organizations. Neither distribution program functions as a contraceptive social marketing (CSM) program, but each system reviewed has aspects that are relevant to CSM commodity management needs. Both the Thai and Brazilian systems were designed to be as automatic and user friendly as possible. Both have 3 main databases and perform similar management and reporting functions. Differing program configurations and basic data forms reflect the specific purposes of each system. Databases for the logistics monitoring system in Thailand arethe reporting entity (or ID) file; the current month's data file; and the master balance file. The data source is the basic reporting form that also serves as a Request and Issue Voucher for commodities. Editing functions in the program check to see that the current "beginning balance" equals the previous month's ending balance. Indexing functions in the system allow direct access to the records of any reporting entity via the ID number, as well as the sequential processing of records by ID number. 6 reports can be generated: status report by issuing entity; status report by dispensing entity; aggregate status report; out of compliance products report; out of compliance outlets report; and suggested shipment to regional warehouse report. Databases for the distribution management system in Brazil are: the name-ID (client institution) file; the product file; and the data file. The data source is an order form that contains a client code similar to the code used in Thailand. An interrogative data entry program enhances the management function of the system. 8 reports can be individually issued: a status report on back orders by product; a status report on back orders by institution and product; a historical report of year to date shipments and value by product; a historical report of year to date shipments by client and product; year to date payment reports from each client; outstanding invoices by month for the previous 12 months; a product report showing the amount of each product or order with outstanding invoices; and a stock position report.

Analysis of Bearing Capacity Pile Foundation with Using Capwap Software for Testing Pile Driving Analyzer (pda) at Fasfel Development Project Parlimbungan Ketek Sikara-Kara Mandailing Natal District (north Sumatera)

NASA Astrophysics Data System (ADS)

Oberlyn Simanjuntak, Johan; Suita, Diana

2017-12-01

Pile foundation is one type deep foundation that serves to distribute the load of hard soil structure loading which has a high bearing capacity that is located deep enough inside the soil. To determine the bearing capacity of the pile and at the same time control the Calendring results, the Pile Driving Analyzer (PDA) test at 8 pile sections from the 84 point piling section (10% of the number sections), the results were analyzed by CAPWAP SOFTWARE, and the highest bearing capacity of Ru 177 ton and the lowest bearing capacity of 111 tons, is bigger than the plan load which load plans that is 60,9 tons. Finally the PDA safe is bearing bearing capacity of the load planning.

Evaluation of wheelchair back support crashworthiness: combination wheelchair back support surfaces and attachment hardware.

PubMed

Ha, D; Bertocci, G; Deemer, E; van Roosmalen, L; Karg, P

2000-01-01

Automotive seats are tested for compliance with federal motor vehicle safety standards (FMVSS) to assure safety during impact. Many wheelchair users rely upon their wheelchairs to serve as vehicle seats. However, the crashworthiness of these wheelchairs during impact is often unknown. This study evaluated the crashworthiness of five combinations of wheelchair back support surfaces and attachment hardware using a static test procedure simulating crash loading conditions. The crashworthiness was tested by applying a simulated rearward load to each seat-back system. The magnitude of the applied load was established through computer simulation and biodynamic calculations. None of the five tested wheelchair back supports withstood the simulated crash loads. All failures were associated with attachment hardware.

Tunable drug loading and release from polypeptide multilayer nanofilms

PubMed Central

Jiang, Bingbing; Li, Bingyun

2009-01-01

Polypeptide multilayer nanofilms were prepared using electrostatic layer-by-layer self-assembly nanotechnology. Small charged drug molecules (eg, cefazolin, gentamicin, and methylene blue) were loaded in polypeptide multilayer nanofilms. Their loading and release were found to be pH-dependent and could also be controlled by changing the number of film layers and drug incubation time, and applying heat-treatment after film formation. Antibioticloaded polypeptide multilayer nanofilms showed controllable antibacterial properties against Staphylococcus aureus. The developed biodegradable polypeptide multilayer nanofilms are capable of loading both positively- and negatively-charged drug molecules and promise to serve as drug delivery systems on biomedical devices for preventing biomedical device-associated infection, which is a significant clinical complication for both civilian and military patients. PMID:19421369

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunsberger, Randolph; Tomberlin, Gregg; Gaul, Chris

As part of the Army Net-Zero Energy Installation program, the Fort Carson Army Base requested that NREL evaluate the feasibility of adding a biomass boiler to the district heating system served by Building 1860. We have also developed an Excel-spreadsheet-based decision support tool--specific to the historic loads served by Building 1860--with which users can perform what-if analysis on gas costs, biomass costs, and other parameters. For economic reasons, we do not recommend adding a biomass system at this time.

Effects of the Racket Polar Moment of Inertia on Dominant Upper Limb Joint Moments during Tennis Serve

PubMed Central

Rogowski, Isabelle; Creveaux, Thomas; Chèze, Laurence; Macé, Pierre; Dumas, Raphaël

2014-01-01

This study examined the effect of the polar moment of inertia of a tennis racket on upper limb loading in the serve. Eight amateur competition tennis players performed two sets of 10 serves using two rackets identical in mass, position of center of mass and moments of inertia other than the polar moment of inertia (0.00152 vs 0.00197 kg.m2). An eight-camera motion analysis system collected the 3D trajectories of 16 markers, located on the thorax, upper limbs and racket, from which shoulder, elbow and wrist net joint moments and powers were computed using inverse dynamics. During the cocking phase, increased racket polar moment of inertia was associated with significant increases in the peak shoulder extension and abduction moments, as well the peak elbow extension, valgus and supination moments. During the forward swing phase, peak wrist extension and radial deviation moments significantly increased with polar moment of inertia. During the follow-through phase, the peak shoulder adduction, elbow pronation and wrist external rotation moments displayed a significant inverse relationship with polar moment of inertia. During the forward swing, the magnitudes of negative joint power at the elbow and wrist were significantly larger when players served using the racket with a higher polar moment of inertia. Although a larger polar of inertia allows players to better tolerate off-center impacts, it also appears to place additional loads on the upper extremity when serving and may therefore increase injury risk in tennis players. PMID:25117871

Short Term Load Forecasting with Fuzzy Logic Systems for power system planning and reliability-A Review

NASA Astrophysics Data System (ADS)

Holmukhe, R. M.; Dhumale, Mrs. Sunita; Chaudhari, Mr. P. S.; Kulkarni, Mr. P. P.

2010-10-01

Load forecasting is very essential to the operation of Electricity companies. It enhances the energy efficient and reliable operation of power system. Forecasting of load demand data forms an important component in planning generation schedules in a power system. The purpose of this paper is to identify issues and better method for load foecasting. In this paper we focus on fuzzy logic system based short term load forecasting. It serves as overview of the state of the art in the intelligent techniques employed for load forecasting in power system planning and reliability. Literature review has been conducted and fuzzy logic method has been summarized to highlight advantages and disadvantages of this technique. The proposed technique for implementing fuzzy logic based forecasting is by Identification of the specific day and by using maximum and minimum temperature for that day and finally listing the maximum temperature and peak load for that day. The results show that Load forecasting where there are considerable changes in temperature parameter is better dealt with Fuzzy Logic system method as compared to other short term forecasting techniques.

Modeling Interactions Between Flexible Flapping Wing Spars, Mechanisms, and Drive Motors

DTIC Science & Technology

2011-09-01

of dynamical equations is presented that allow micro air vehicle (MAV) or- nithopter designers to match drive motors to loads produced by flexible...aeroelastic systems is presented. One potential use for such a model is to serve as the basis for a vehicle design tool that matches drive motors to loads...friction. ∗Senior Aerospace Engineer, Control Design and Analysis Branch, 2210 Eighth Street, Ste. 21, Air Force Research Labora- tory, WPAFB, OH 45433

[Three-dimensional finite element analysis on cell culture membrane under mechanical load].

PubMed

Guo, Xin; Fan, Yubo; Song, Jinlin; Chen, Junkai

2002-01-01

A three-dimensional finite element model of the cell culture membrane was developed in the culture device under tension state made by us. The magnitude of tension and the displacement distribution in the membrane made of silicon rubber under different hydrostatic load were obtained by use of FEM analysis. A comparative study was made between the numerical and the experimental results. These results can serve as guides to the related cellular mechanical research.

A variable acceleration calibration system

NASA Astrophysics Data System (ADS)

Johnson, Thomas H.

2011-12-01

A variable acceleration calibration system that applies loads using gravitational and centripetal acceleration serves as an alternative, efficient and cost effective method for calibrating internal wind tunnel force balances. Two proof-of-concept variable acceleration calibration systems are designed, fabricated and tested. The NASA UT-36 force balance served as the test balance for the calibration experiments. The variable acceleration calibration systems are shown to be capable of performing three component calibration experiments with an approximate applied load error on the order of 1% of the full scale calibration loads. Sources of error are indentified using experimental design methods and a propagation of uncertainty analysis. Three types of uncertainty are indentified for the systems and are attributed to prediction error, calibration error and pure error. Angular velocity uncertainty is shown to be the largest indentified source of prediction error. The calibration uncertainties using a production variable acceleration based system are shown to be potentially equivalent to current methods. The production quality system can be realized using lighter materials and a more precise instrumentation. Further research is needed to account for balance deflection, forcing effects due to vibration, and large tare loads. A gyroscope measurement technique is shown to be capable of resolving the balance deflection angle calculation. Long term research objectives include a demonstration of a six degree of freedom calibration, and a large capacity balance calibration.

Dynamic optical resource allocation for mobile core networks with software defined elastic optical networking.

PubMed

Zhao, Yongli; Chen, Zhendong; Zhang, Jie; Wang, Xinbo

2016-07-25

Driven by the forthcoming of 5G mobile communications, the all-IP architecture of mobile core networks, i.e. evolved packet core (EPC) proposed by 3GPP, has been greatly challenged by the users' demands for higher data rate and more reliable end-to-end connection, as well as operators' demands for low operational cost. These challenges can be potentially met by software defined optical networking (SDON), which enables dynamic resource allocation according to the users' requirement. In this article, a novel network architecture for mobile core network is proposed based on SDON. A software defined network (SDN) controller is designed to realize the coordinated control over different entities in EPC networks. We analyze the requirement of EPC-lightpath (EPCL) in data plane and propose an optical switch load balancing (OSLB) algorithm for resource allocation in optical layer. The procedure of establishment and adjustment of EPCLs is demonstrated on a SDON-based EPC testbed with extended OpenFlow protocol. We also evaluate the OSLB algorithm through simulation in terms of bandwidth blocking ratio, traffic load distribution, and resource utilization ratio compared with link-based load balancing (LLB) and MinHops algorithms.

Vibrations and structureborne noise in space station

NASA Technical Reports Server (NTRS)

Vaicaitis, R.

1985-01-01

Theoretical models were developed capable of predicting structural response and noise transmission to random point mechanical loads. Fiber reinforced composite and aluminum materials were considered. Cylindrical shells and circular plates were taken as typical representatives of structural components for space station habitability modules. Analytical formulations include double wall and single wall constructions. Pressurized and unpressurized models were considered. Parametric studies were conducted to determine the effect on structural response and noise transmission due to fiber orientation, point load location, damping in the core and the main load carrying structure, pressurization, interior acoustic absorption, etc. These analytical models could serve as preliminary tools for assessing noise related problems, for space station applications.

Multifunctional Structures for High-Energy Lightweight Load-Bearing Storage

NASA Technical Reports Server (NTRS)

Loyselle, Patricia L.

2018-01-01

This is a pull-up banner of the Multifunctional Structures for High-Energy Lightweight Load-bearing Storage (M-SHELLS) technology that will be on display at the SciTech Conference in January 2018. Efforts in Multifunctional Structures for High Energy Load-Bearing Storage (M-Shells) are pushing the boundaries of development for hybrid electric propulsion for future commercial aeronautical transport. The M-Shells hybrid material would serve as the power/energy storage of the vehicle and provide structural integrity, freeing up usable volume and mass typically occupied by bulky batteries. The ultimate goal is to demonstrate a system-level mass savings with a multifunctional structure with energy storage.

78 FR 25013 - Medicare Program; Requirements for the Medicare Incentive Reward Program and Provider Enrollment

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-29

...This proposed rule would revise the Incentive Reward Program provisions in Sec. 420.405 and certain provider enrollment requirements in part 424, subpart P. The most significant of these revisions include: changing the Incentive Reward Program potential reward amount for information on individuals and entities who are or have engaged in acts or omissions which resulted in the imposition of a sanction from 10 percent of the overpayments recovered in the case or $1,000, whichever is less, to 15 percent of the final amount collected applied to the first $66,000,000 for the sanctionable conduct; expanding the instances in which a felony conviction can serve as a basis for denial or revocation of a provider or supplier's enrollment; if certain criteria are met, enabling us to deny enrollment if the enrolling provider, supplier, or owner thereof had an ownership relationship with a previously enrolled provider or supplier that had a Medicare debt; enabling us to revoke Medicare billing privileges if we determine that the provider or supplier has a pattern or practice of submitting claims for services that fail to meet Medicare requirements; and limiting the ability of ambulance suppliers to ``backbill'' for services performed prior to enrollment. We believe this proposed rule would--increase the incentive for individuals to report information on individuals and entities that have or are engaged in sanctionable conduct; improve our ability to detect new fraud schemes; and help us ensure that fraudulent entities and individuals do not enroll in or maintain their enrollment in the Medicare program.

Missisquoi Bay Phosphorus Model Addendum

EPA Pesticide Factsheets

This technical memorandum provides results of an extended load reduction simulation. The memorandum serves as an addendum to the main Missisquoi Bay Phosphorus Mass Balance Model report prepared for the Lake Champlain Basin Program by LimnoTech in 2012

Semen inhibits Zika virus infection of cells and tissues from the anogenital region.

PubMed

Müller, Janis A; Harms, Mirja; Krüger, Franziska; Groß, Rüdiger; Joas, Simone; Hayn, Manuel; Dietz, Andrea N; Lippold, Sina; von Einem, Jens; Schubert, Axel; Michel, Manuela; Mayer, Benjamin; Cortese, Mirko; Jang, Karen S; Sandi-Monroy, Nathallie; Deniz, Miriam; Ebner, Florian; Vapalahti, Olli; Otto, Markus; Bartenschlager, Ralf; Herbeuval, Jean-Philippe; Schmidt-Chanasit, Jonas; Roan, Nadia R; Münch, Jan

2018-06-07

Zika virus (ZIKV) causes severe birth defects and can be transmitted via sexual intercourse. Semen from ZIKV-infected individuals contains high viral loads and may therefore serve as an important vector for virus transmission. Here we analyze the effect of semen on ZIKV infection of cells and tissues derived from the anogenital region. ZIKV replicates in all analyzed cell lines, primary cells, and endometrial or vaginal tissues. However, in the presence of semen, infection by ZIKV and other flaviviruses is potently inhibited. We show that semen prevents ZIKV attachment to target cells, and that an extracellular vesicle preparation from semen is responsible for this anti-ZIKV activity. Our findings suggest that ZIKV transmission is limited by semen. As such, semen appears to serve as a protector against sexual ZIKV transmission, despite the availability of highly susceptible cells in the anogenital tract and high viral loads in this bodily fluid.

Direct Numerical Simulations of Microstructure Effects During High-Rate Loading of Additively Manufactured Metals

NASA Astrophysics Data System (ADS)

Battaile, Corbett; Owen, Steven; Moore, Nathan

2017-06-01

The properties of most engineering materials depend on the characteristics of internal microstructures and defects. In additively manufactured (AM) metals, these can include polycrystalline grains, impurities, phases, and significant porosity that qualitatively differ from conventional engineering materials. The microscopic details of the interactions between these internal defects, and the propagation of applied loads through the body, act in concert to dictate macro-observable properties like strength and compressibility. In this work, we used Sandia's ALEGRA finite element software to simulate the high-strain-rate loading of AM metals from laser engineered net shaping (LENS) and thermal spraying. The microstructural details of the material were represented explicitly, such that internal features like second phases and pores are captured and meshed as individual entities in the computational domain. We will discuss the dependence of the high-strain-rate mechanical properties on microstructural characteristics such as the shapes, sizes, and volume fractions of second phases and pores. In addition, we will examine how the details of the microstructural representation affect the microscopic material response to dynamic loads, and the effects of using ``stair-step'' versus conformal interfaces smoothed via the SCULPT tool in Sandia's CUBIT software. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the US DOE NNSA under contract DE-AC04-94AL85000.

Dynamic plasticity and failure of high-purity alumina under shock loading.

PubMed

Chen, M W; McCauley, J W; Dandekar, D P; Bourne, N K

2006-08-01

Most high-performance ceramics subjected to shock loading can withstand high failure strength and exhibit significant inelastic strain that cannot be achieved under conventional loading conditions. The transition point from elastic to inelastic response prior to failure during shock loading, known as the Hugoniot elastic limit (HEL), has been widely used as an important parameter in the characterization of the dynamic mechanical properties of ceramics. Nevertheless, the underlying micromechanisms that control HEL have been debated for many years. Here we show high-resolution electron microscopy of high-purity alumina, soft-recovered from shock-loading experiments. The change of deformation behaviour from dislocation activity in the vicinity of grain boundaries to deformation twinning has been observed as the impact pressures increase from below, to above HEL. The evolution of deformation modes leads to the conversion of material failure from an intergranular mode to transgranular cleavage, in which twinning interfaces serve as the preferred cleavage planes.

Dual band new bisected-Π CRLH metamaterial cell loaded dipole antennas

NASA Astrophysics Data System (ADS)

Abdalla, M. A.; Ghouz, M. H.; Abo El-Dahab, M.

2018-06-01

In this paper, two different designs for new metamaterial loaded dipole antenna are presented. The designs are based on loading printed dipole antennas with modified versions of composite right left handed cells. Different objectives are intended for these new designs; which are achieving compact size, dual band functionalities and good gain of the loaded dipole antenna. The designed antennas can serve different wireless services for GPS (1.227 GHz and 1.57 GHz), Universal Telecommunications System (UMTS 1.9 GHz), and WiFi (2.4 GHz). The two presented antennas have gain whose values are better than 1.9 dB up to 3.5 dB at all operating frequencies. The designed loading has reduced the physical / electrical length of conventional dipole antenna by 25%. The theoretical analysis, circuit model, full wave simulations and experimental measurements of the reported antennas are introduced.

POSTOP: Postbuckled open-stiffener optimum panels, user's manual

NASA Technical Reports Server (NTRS)

Biggers, S. B.; Dickson, J. N.

1984-01-01

The computer program POSTOP developed to serve as an aid in the analysis and sizing of stiffened composite panels that may be loaded in the postbuckling regime, is intended for the preliminary design of metal or composite panels with open-section stiffeners, subjected to multiple combined biaxial compression (or tension), shear and normal pressure load cases. Longitudinal compression, however, is assumed to be the dominant loading. Temperature, initial bow eccentricity and load eccentricity effects are included. The panel geometry is assumed to be repetitive over several bays in the longitudinal (stiffener) direction as well as in the transverse direction. Analytical routines are included to compute panel stiffnesses, strains, local and panel buckling loads, and skin/stiffener interface stresses. The resulting program is applicable to stiffened panels as commonly used in fuselage, wing, or empennage structures. The capabilities and limitations of the code are described. Instructions required to use the program and several example problems are included.

Structural optimization of 3D-printed synthetic spider webs for high strength

NASA Astrophysics Data System (ADS)

Qin, Zhao; Compton, Brett G.; Lewis, Jennifer A.; Buehler, Markus J.

2015-05-01

Spiders spin intricate webs that serve as sophisticated prey-trapping architectures that simultaneously exhibit high strength, elasticity and graceful failure. To determine how web mechanics are controlled by their topological design and material distribution, here we create spider-web mimics composed of elastomeric filaments. Specifically, computational modelling and microscale 3D printing are combined to investigate the mechanical response of elastomeric webs under multiple loading conditions. We find the existence of an asymptotic prey size that leads to a saturated web strength. We identify pathways to design elastomeric material structures with maximum strength, low density and adaptability. We show that the loading type dictates the optimal material distribution, that is, a homogeneous distribution is better for localized loading, while stronger radial threads with weaker spiral threads is better for distributed loading. Our observations reveal that the material distribution within spider webs is dictated by the loading condition, shedding light on their observed architectural variations.

Structural optimization of 3D-printed synthetic spider webs for high strength.

PubMed

Qin, Zhao; Compton, Brett G; Lewis, Jennifer A; Buehler, Markus J

2015-05-15

Spiders spin intricate webs that serve as sophisticated prey-trapping architectures that simultaneously exhibit high strength, elasticity and graceful failure. To determine how web mechanics are controlled by their topological design and material distribution, here we create spider-web mimics composed of elastomeric filaments. Specifically, computational modelling and microscale 3D printing are combined to investigate the mechanical response of elastomeric webs under multiple loading conditions. We find the existence of an asymptotic prey size that leads to a saturated web strength. We identify pathways to design elastomeric material structures with maximum strength, low density and adaptability. We show that the loading type dictates the optimal material distribution, that is, a homogeneous distribution is better for localized loading, while stronger radial threads with weaker spiral threads is better for distributed loading. Our observations reveal that the material distribution within spider webs is dictated by the loading condition, shedding light on their observed architectural variations.

The Connecticut Mental Health Center: Celebrating 50 Years of a Successful Partnership Between the State and Yale University.

PubMed

Steiner, Jeanne L; Anez-Nava, Luis; Baranoski, Madelon; Cole, Robert; Davidson, Larry; Delphin-Rittmon, Miriam; Dike, Charles; DiLeo, Paul J; Duman, Ronald S; Kirk, Thomas; Krystal, John; Malison, Robert T; Rohrbaugh, Robert M; Sernyak, Michael J; Srihari, Vinod; Styron, Thomas; Tebes, Jacob K; Woods, Scott; Zonana, Howard; Jacobs, Selby C

2016-12-01

September 28, 2016, marked the 50th anniversary of the Connecticut Mental Health Center, a state-owned and state-operated joint venture between the state and Yale University built and sustained with federal, state, and university funds. Collaboration across these entities has produced a wide array of clinical, educational, and research initiatives, a few of which are described in this column. The missions of clinical care, research, and education remain the foundation for an organization that serves 5,000 individuals each year who are poor and who experience serious mental illnesses and substance use disorders.

Well-studied Cu-BTC still serves surprises: evidence for facile Cu2+/Cu+ interchange.

PubMed

Szanyi, Janos; Daturi, Marco; Clet, Guillaume; Baer, Donald R; Peden, Charles H F

2012-04-07

Cu-BTC (also known as HKUST-1) is a well-characterized metal-organic framework material produced in an industrial scale and widely studied for a number of potential applications by the scientific community. The co-existence of Cu(+) and Cu(2+) entities has already been observed in this material, but the presence of Cu(+) ions was attributed to oxide impurities. The results presented here clearly demonstrate that Cu(+) ions can be present in high concentrations inside the hybrid structure. Furthermore, switching between the two copper oxidation states can be induced by redox treatments, using vacuum and/or reducing gases at different sample temperatures.

Well-studied Cu-BTC still serves surprises: evidence for facile Cu2+/Cu+ interchange

DOE Office of Scientific and Technical Information (OSTI.GOV)

Szanyi, Janos; Daturi, Marco; Clet, Guillame

2012-03-08

Cu-BTC (also known as HKUST-1) is a well-characterized Metal Organic Framework material produced in industrial scale and widely studied for a number of potential applications by the scientific community. The co-existence of Cu+ and Cu2+ entities has already been observed in this material, but the presence of Cu+ ions was attributed to oxide impurities. The results presented here clearly demonstrate that Cu+ ions can be present in high concentrations inside the hybrid structure. Furthermore, switching between the two copper oxidation states can be induced by redox treatments, using vacuum and/or reducing gases at different sample temperatures.

Marine and Other Aquatic Dermatoses

PubMed Central

Sridhar, Surg Capt. Jandhyala; Deo, Surg Cdr. Rajeev

2017-01-01

Occupational and recreational aquatic activity predisposes our population to a wide variety of dermatoses. Sunburn, urticaria, jellyfish stings, and contact dermatitis to rubber equipment are common allergies that are encountered in the aquatic environment. Among the infections, tinea versicolor, intertrigo, and verruca vulgaris are widespread. Swimmer's itch may occur due to skin penetration by schistosome cercariae, while free-floating nematocysts of marine coelenterates may precipitate seabather's eruption. “Suit squeeze” due to cutaneous barotrauma and lymphoedematous peau d’orange due to decompression are rare, described entities. This review serves as a ready reckoner for Indian dermatologists and medical practitioners to identify and manage these conditions. PMID:28216728

Encoding of Fundamental Chemical Entities of Organic Reactivity Interest using chemical ontology and XML.

PubMed

Durairaj, Vijayasarathi; Punnaivanam, Sankar

2015-09-01

Fundamental chemical entities are identified in the context of organic reactivity and classified as appropriate concept classes namely ElectronEntity, AtomEntity, AtomGroupEntity, FunctionalGroupEntity and MolecularEntity. The entity classes and their subclasses are organized into a chemical ontology named "ChemEnt" for the purpose of assertion, restriction and modification of properties through entity relations. Individual instances of entity classes are defined and encoded as a library of chemical entities in XML. The instances of entity classes are distinguished with a unique notation and identification values in order to map them with the ontology definitions. A model GUI named Entity Table is created to view graphical representations of all the entity instances. The detection of chemical entities in chemical structures is achieved through suitable algorithms. The possibility of asserting properties to the entities at different levels and the mechanism of property flow within the hierarchical entity levels is outlined. Copyright © 2015 Elsevier Inc. All rights reserved.

Bacterial Growth Kinetics under a Novel Flexible Methacrylate Dressing Serving as a Drug Delivery Vehicle for Antiseptics

PubMed Central

Forstner, Christina; Leitgeb, Johannes; Schuster, Rupert; Dosch, Verena; Kramer, Axel; Cutting, Keith F.; Leaper, David J.; Assadian, Ojan

2013-01-01

A flexible methacrylate powder dressing (Altrazeal®) transforms into a wound contour conforming matrix once in contact with wound exudate. We hypothesised that it may also serve as a drug delivery vehicle for antiseptics. The antimicrobial efficacy and influence on bacterial growth kinetics in combination with three antiseptics was investigated in an in vitro porcine wound model. Standardized in vitro wounds were contaminated with Staphylococcus aureus (MRSA; ATCC 33591) and divided into six groups: no dressing (negative control), methacrylate dressing alone, and combinations with application of 0.02% Polyhexamethylene Biguanide (PHMB), 0.4% PHMB, 0.1% PHMB + 0.1% betaine, 7.7 mg/mL Povidone-iodine (PVP-iodine), and 0.1% Octenidine-dihydrochloride (OCT) + 2% phenoxyethanol. Bacterial load per gram tissue was measured over five days. The highest reduction was observed with PVP-iodine at 24 h to log10 1.43 cfu/g, followed by OCT at 48 h to log10 2.41 cfu/g. Whilst 0.02% PHMB resulted in a stable bacterial load over 120 h to log10 4.00 cfu/g over 120 h, 0.1% PHMB + 0.1% betaine inhibited growth during the first 48 h, with slightly increasing bacterial numbers up to log10 5.38 cfu/g at 120 h. These results indicate that this flexible methacrylate dressing can be loaded with various antiseptics serving as drug delivery system. Depending on the selected combination, an individually shaped and controlled antibacterial effect may be achieved using the same type of wound dressing. PMID:23698780

A Review of Research on Impulsive Loading of Marine Composites

NASA Astrophysics Data System (ADS)

Porfiri, Maurizio; Gupta, Nikhil

Impulsive loading conditions, such as those produced by blast waves, are being increasingly recognized as relevant in marine applications. Significant research efforts are directed towards understanding the impulsive loading response of traditional naval materials, such as aluminum and steel, and advanced composites, such as laminates and sandwich structures. Several analytical studies are directed towards establishing predictive models for structural response and failure of marine structures under blast loading. In addition, experimental research efforts are focused on characterizing structural response to blast loading. The aim of this review is to provide a general overview of the state of the art on analytical and experimental studies in this field that can serve as a guideline for future research directions. Reported studies cover the Office of Naval Research-Solid Mechanics Program sponsored research along with other worldwide research efforts of relevance to marine applications. These studies have contributed to developing a fundamental knowledge of the mechanics of advanced materials subjected to impulsive loading, which is of interest to all Department of Defense branches.

Local structural mechanism for frozen-in dynamics in metallic glasses

NASA Astrophysics Data System (ADS)

Liu, X. J.; Wang, S. D.; Wang, H.; Wu, Y.; Liu, C. T.; Li, M.; Lu, Z. P.

2018-04-01

The nature of the glass transition is a fundamental and long-standing intriguing issue in the condensed-matter physics and materials science community. In particular, the structural response by which a liquid is arrested dynamically to form a glass or amorphous solid upon approaching its freezing temperature [the glass transition temperature (Tg)] remains unclear. Various structural scenarios in terms of the percolation theory have been proposed recently to understand such a phenomenon; however, there is still no consensus on what the general percolation entity is and how the entity responds to the sudden slowdown dynamics during the glass transition. In this paper, we demonstrate that one-dimensional local linear ordering (LLO) is a universal structural motif associated with the glass transition for various metallic glasses. The quantitative evolution of LLO with temperature indicates that a percolating LLO network forms to serve as the backbone of the rigid glass solid when the temperature approaches the freezing point, resulting in the frozen-in dynamics accompanying the glass transition. The percolation transition occurs by pinning different LLO networks together, which only needs the introduction of a small number of "joint" atoms between them, and therefore the energy expenditure is very low.

From data to knowledge through concept-oriented terminologies: experience with the Medical Entities Dictionary.

PubMed

Cimino, J J

2000-01-01

Knowledge representation involves enumeration of conceptual symbols and arrangement of these symbols into some meaningful structure. Medical knowledge representation has traditionally focused more on the structure than the symbols. Several significant efforts are under way, at local, national, and international levels, to address the representation of the symbols though the creation of high-quality terminologies that are themselves knowledge based. This paper reviews these efforts, including the Medical Entities Dictionary (MED) in use at Columbia University and the New York Presbyterian Hospital. A decade's experience with the MED is summarized to serve as a proof-of-concept that knowledge-based terminologies can support the use of coded patient data for a variety of knowledge-based activities, including the improved understanding of patient data, the access of information sources relevant to specific patient care problems, the application of expert systems directly to the care of patients, and the discovery of new medical knowledge. The terminological knowledge in the MED has also been used successfully to support clinical application development and maintenance, including that of the MED itself. On the basis of this experience, current efforts to create standard knowledge-based terminologies appear to be justified.

Modulation of Electrophysiology by Transcranial Direct Current Stimulation in Psychiatric Disorders: A Systematic Review.

PubMed

Kim, Minah; Kwak, Yoo Bin; Lee, Tae Young; Kwon, Jun Soo

2018-04-27

Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique increasingly used to relieve symptoms of psychiatric disorders. Electrophysiologic markers, such as electroencephalography (EEG) and event-related potentials (ERP), have high temporal resolution sensitive to detect plastic changes of the brain associated with symptomatic improvement following tDCS application. We performed systematic review to identify electrophysiological markers that reflect tDCS effects on plastic brain changes in psychiatric disorders. A total of 638 studies were identified by searching PubMed, Embase, psychINFPO. Of these, 21 full-text articles were assessed eligible and included in the review. Although the reviewed studies were heterogeneous in their choices of tDCS protocols, targeted electrophysiological markers, and disease entities, their results strongly support EEG/ERPs to sensitively reflect plastic brain changes and the associated symptomatic improvement following tDCS. EEG/ERPs may serve a potent tool in revealing the mechanisms underlying psychiatric symptoms, as well as in localizing the brain area targeted for stimulation. Future studies in each disease entities employing consistent tDCS protocols and electrophysiological markers would be necessary in order to substantiate and further elaborate the findings of studies included in the present systematic review.

Follicular vitiligo: A report of 8 cases.

PubMed

Gan, Emily Yiping; Cario-André, Muriel; Pain, Catherine; Goussot, Jean-Francois; Taïeb, Alain; Seneschal, Julien; Ezzedine, Khaled

2016-06-01

Follicular vitiligo, a recently proposed new subtype of vitiligo, has primary involvement of the hair follicle melanocytic reservoir. We sought to characterize follicular vitiligo through a case series of 8 patients. Patients with features of follicular vitiligo who were seen at the vitiligo clinic in the National Center for Rare Skin Disorders in Bordeaux, France, were recruited. A retrospective review of case records and clinical photographs was carried out. There were 8 male patients with a mean age of 48 years. All patients reported significant whitening of their body and, in some, scalp hairs before cutaneous depigmentation. Examination revealed classic generalized depigmented lesions of vitiligo and an impressive presence of leukotrichia, not only in the vitiliginous areas, but also in areas with clinically normal-appearing skin. Punch biopsy specimen of the leukotrichia and vitiligo lesions demonstrated loss of melanocytes and precursors in the basal epidermis and hair follicle. This was a cross-sectional study based on a single-center experience. Follicular vitiligo is a distinct entity within the spectrum of vitiligo. This entity may serve as the missing link between alopecia areata and vitiligo, with probable physiopathological similarities between these conditions. Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

In-time source tracking of watershed loads of Taihu Lake Basin, China based on spatial relationship modeling.

PubMed

Wang, Ce; Bi, Jun; Zhang, Xu-Xiang; Fang, Qiang; Qi, Yi

2018-05-25

Influent river carrying cumulative watershed load plays a significant role in promoting nuisance algal bloom in river-fed lake. It is most relevant to discern in-stream water quality exceedance and evaluate the spatial relationship between risk location and potential pollution sources. However, no comprehensive studies of source tracking in watershed based on management grid have been conducted for refined water quality management, particularly for plain terrain with complex river network. In this study, field investigations were implemented during 2014 in Taige Canal watershed of Taihu Lake Basin. A Geographical Information System (GIS)-based spatial relationship model was established to characterize the spatial relationships of "point (point-source location and monitoring site)-line (river segment)-plane (catchment)." As a practical exemplification, in-time source tracking was triggered on April 15, 2015 at Huangnianqiao station, where TN and TP concentration violated the water quality standard (TN 4.0 mg/L, TP 0.15 mg/L). Of the target grid cells, 53 and 46 were identified as crucial areas having high pollution intensity for TN and TP pollution, respectively. The estimated non-point source load in each grid cell could be apportioned into different source types based on spatial pollution-related entity objects. We found that the non-point source load derived from rural sewage and livestock and poultry breeding accounted for more than 80% of total TN or TP load than another source type of crop farming. The approach in this study would be of great benefit to local authorities for identifying the serious polluted regions and efficiently making environmental policies to reduce watershed load.

Design of Large Stone Asphalt Mixes to Minimize Rutting

DOT National Transportation Integrated Search

1990-01-01

Rutting of heavy duty asphalt pavements has been increasingly experienced in recent years. This phenomenon is primarily resulting from high tire pressures and increased wheel loads. The design of Hot Mix Asphalt (HMA) which served reasonably well in ...

Heat Load Sharing in a Capillary Pumped Loop with Multiple Evaporators and Multiple Condensers

NASA Technical Reports Server (NTRS)

Ku, Jentung

2005-01-01

This paper describes the heat load sharing function among multiple parallel evaporators in a capillary pumped loop (CPL). In the normal mode of operation, the evaporators cool the instruments by absorbing the waste heat. When an instruments is turned off, the attached evaporator can keep it warm by receiving heat from other evaporators serving the operating instruments. This is referred to as heat load sharing. A theoretical basis of heat load sharing is given first. The fact that the wicks in the powered evaporators will develop capillary pressure to force the generated vapor to flow to cold locations where the pressure is lower leads to the conclusion that heat load sharing is an inherent function of a CPL with multiple evaporators. Heat load sharing has been verified with many CPLs in ground tests. Experimental results of the Capillary Pumped Loop 3 (CAPL 3) Flight Experiment are presented in this paper. Factors that affect the amount of heat being shared are discussed. Some constraints of heat load sharing are also addressed.

Notices and Policies for Retractions, Expressions of Concern, Errata and Corrigenda: Their Importance, Content, and Context.

PubMed

Teixeira da Silva, Jaime A; Dobránszki, Judit

2017-04-01

A retraction notice is an essential scientific historical document because it should outline the reason(s) why a scientific manuscript was retracted, culpability (if any) and any other factors that have given reason for the authors, editors, or publisher, to remove a piece of the literature from science's history books. Unlike an expression of concern (EoC), erratum or corrigendum, a retraction will usually result in a rudimentary vestige of the work. Thus, any retraction notice that does not fully indicate a set of elements related to the reason and background for the retraction serves as a poor historical document. Moreover, poorly or incompletely worded retraction notices in fact do not serve their intended purpose, i.e., to hold all parties accountable, and to inform the scientific and wider public of the problem and reason for the paper's demise. This paper takes a look at the definitions and the policies of clauses for retractions, EoCs, errata and corrigenda in place by 15 leading science, technology and medicine (STM) publishers and four publishing-related bodies that we believe have the greatest influence on the current fields of science, technology and medicine. The primary purpose was to assess whether there is a consistency among these entities and publishers. Using an arbitrary 5-scale classification system, and evaluating the different categories of policies separately, we discovered that in almost all cases (88.9 %), the wording used to define these four categories of polices differs from that of the Committee on Publication Ethics (COPE), which is generally considered to be the guiding set of definitions in science publishing. In addition, as much as 61 % deviation in policies (wording and meaning), relative to COPE guidelines, was discovered. When considering the average pooled deviation across all categories of policies, we discovered that there was either no deviation or a small deviation, only in the wording, in the definition of policies when compared to the COPE guidelines in 1 out of 3 ethical bodies, and in 40 % (6 out of 15) STM publishers. Moderate deviation from the COPE guidelines was detected in 26.7 % of STM publishers and one ethical body but a large deviation in one ethical body and 20 % of STM publishers was observed. Two STM publishers (13.3 %) did not report any information about these policies. Even though in practice, editors and publishers may deviate from these written definitions when dealing with case-by-case issues, we believe that it is essential, to serve as a consistent guide for authors and editors, that the wording be standardized across these entities. COPE and these entities also have the responsibility of making it clear that these definitions are merely suggestions and that their application may be subjected to subjective interpretation and application.

Multiple Osteochondral Allograft Transplantation with Concomitant Tibial Tubercle Osteotomy for Multifocal Chondral Disease of the Knee.

PubMed

Cotter, Eric J; Waterman, Brian R; Kelly, Mick P; Wang, Kevin C; Frank, Rachel M; Cole, Brian J

2017-08-01

Symptomatic patellofemoral chondral lesions are a challenging clinical entity, as these defects may result from persistent lateral patellar maltracking or repetitive microtrauma. Anteromedializing tibial tubercle osteotomy has been shown to be an effective strategy for primary and adjunctive treatment of focal or diffuse patellofemoral disease to improve the biomechanical loading environment. Similarly, osteochondral allograft transplantation has proven efficacy in physiologically young, high-demand patients with condylar or patellofemoral lesions, particularly without early arthritic progression. The authors present the surgical management of a young athlete with symptomatic tricompartmental focal chondral defects with fresh osteochondral allograft transplantation and anteromedializing tibial tubercle osteotomy.

The Solar Umbrella: A Low-cost Demonstration of Scalable Space Based Solar Power

NASA Technical Reports Server (NTRS)

Contreras, Michael T.; Trease, Brian P.; Sherwood, Brent

2013-01-01

Within the past decade, the Space Solar Power (SSP) community has seen an influx of stakeholders willing to entertain the SSP prospect of potentially boundless, base-load solar energy. Interested parties affiliated with the Department of Defense (DoD), the private sector, and various international entities have all agreed that while the benefits of SSP are tremendous and potentially profitable, the risk associated with developing an efficient end to end SSP harvesting system is still very high. In an effort to reduce the implementation risk for future SSP architectures, this study proposes a system level design that is both low-cost and seeks to demonstrate the furthest transmission of wireless power to date. The overall concept is presented and each subsystem is explained in detail with best estimates of current implementable technologies. Basic cost models were constructed based on input from JPL subject matter experts and assume that the technology demonstration would be carried out by a federally funded entity. The main thrust of the architecture is to demonstrate that a usable amount of solar power can be safely and reliably transmitted from space to the Earth's surface; however, maximum power scalability limits and their cost implications are discussed.

Improving Agent Bidding in Power Stock Markets through a Data Mining Enhanced Agent Platform

NASA Astrophysics Data System (ADS)

Chrysopoulos, Anthony C.; Symeonidis, Andreas L.; Mitkas, Pericles A.

Like in any other auctioning environment, entities participating in Power Stock Markets have to compete against other in order to maximize own revenue. Towards the satisfaction of their goal, these entities (agents - human or software ones) may adopt different types of strategies - from na?ve to extremely complex ones - in order to identify the most profitable goods compilation, the appropriate price to buy or sell etc, always under time pressure and auction environment constraints. Decisions become even more difficult to make in case one takes the vast volumes of historical data available into account: goods’ prices, market fluctuations, bidding habits and buying opportunities. Within the context of this paper we present Cassandra, a multi-agent platform that exploits data mining, in order to extract efficient models for predicting Power Settlement prices and Power Load values in typical Day-ahead Power markets. The functionality of Cassandra is discussed, while focus is given on the bidding mechanism of Cassandra’s agents, and the way data mining analysis is performed in order to generate the optimal forecasting models. Cassandra has been tested in a real-world scenario, with data derived from the Greek Energy Stock market.

Physical properties, chemical composition, and cloud forming potential of particulate emissions from a marine diesel engine at various load conditions.

PubMed

Petzold, A; Weingartner, E; Hasselbach, J; Lauer, P; Kurok, C; Fleischer, F

2010-05-15

Particulate matter (PM) emissions from one serial 4-stroke medium-speed marine diesel engine were measured for load conditions from 10% to 110% in test rig studies using heavy fuel oil (HFO). Testing the engine across its entire load range permitted the scaling of exhaust PM properties with load. Emission factors for particle number, particle mass, and chemical compounds were determined. The potential of particles to form cloud droplets (cloud condensation nuclei, CCN) was calculated from chemical composition and particle size. Number emission factors are (3.43 +/- 1.26) x 10(16) (kg fuel)(-1) at 85-110% load and (1.06 +/- 0.10) x 10(16) (kg fuel)(-1) at 10% load. CCN emission factors of 1-6 x 10(14) (kg fuel)(-1) are at the lower bound of data reported in the literature. From combined thermal and optical methods, black carbon (BC) emission factors of 40-60 mg/(kg fuel) were determined for 85-100% load and 370 mg/(kg fuel) for 10% load. The engine load dependence of the conversion efficiency for fuel sulfur into sulfate of (1.08 +/- 0.15)% at engine idle to (3.85 +/- 0.41)% at cruise may serve as input to global emission calculations for various load conditions.

14 CFR Appendix E to Part 151 - Appendix E to Part 151

Code of Federal Regulations, 2010 CFR

2010-01-01

...: Typical Eligible Items 1. Basic types of pavement listed as eligible under § 151.77. 2. Loading ramps. 3... of pavement listed as ineligible under § 151.77. 2. Aprons serving installations for nonpublic use. 3...

Extended Glauert tip correction to include vortex rollup effects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maniaci, David; Schmitz, Sven

Wind turbine loads predictions by blade-element momentum theory using the standard tip-loss correction have been shown to over-predict loading near the blade tip in comparison to experimental data. This over-prediction is theorized to be due to the assumption of light rotor loading, inherent in the standard tip-loss correction model of Glauert. A higher- order free-wake method, WindDVE, is used to compute the rollup process of the trailing vortex sheets downstream of wind turbine blades. Results obtained serve an exact correction function to the Glauert tip correction used in blade-element momentum methods. Lastly, it is found that accounting for the effectsmore » of tip vortex rollup within the Glauert tip correction indeed results in improved prediction of blade tip loads computed by blade-element momentum methods.« less

Extended Glauert tip correction to include vortex rollup effects

DOE PAGES

Maniaci, David; Schmitz, Sven

2016-10-03

Wind turbine loads predictions by blade-element momentum theory using the standard tip-loss correction have been shown to over-predict loading near the blade tip in comparison to experimental data. This over-prediction is theorized to be due to the assumption of light rotor loading, inherent in the standard tip-loss correction model of Glauert. A higher- order free-wake method, WindDVE, is used to compute the rollup process of the trailing vortex sheets downstream of wind turbine blades. Results obtained serve an exact correction function to the Glauert tip correction used in blade-element momentum methods. Lastly, it is found that accounting for the effectsmore » of tip vortex rollup within the Glauert tip correction indeed results in improved prediction of blade tip loads computed by blade-element momentum methods.« less

13 CFR 130.200 - Eligible entities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Eligible entities. 130.200 Section... CENTERS § 130.200 Eligible entities. (a) Recipient Organization. The following entities are eligible to... community or junior college; (5) An entity formed by two or more of the above entities; or (6) Any entity...

Managing risks of market price uncertainty for a microgrid operation

NASA Astrophysics Data System (ADS)

Raghavan, Sriram

After deregulation of electricity in the United States, the day-ahead and real-time markets allow load serving entities and generation companies to bid and purchase/sell energy under the supervision of the independent system operator (ISO). The electricity market prices are inherently uncertain, and can be highly volatile. The main objective of this thesis is to hedge against the risk from the uncertainty of the market prices when purchasing/selling energy from/to the market. The energy manager can also schedule distributed generators (DGs) and storage of the microgrid to meet the demand, in addition to energy transactions from the market. The risk measure used in this work is the variance of the uncertain market purchase/sale cost/revenue, assuming the price following a Gaussian distribution. Using Markowitz optimization, the risk is minimized to find the optimal mix of purchase from the markets. The problem is formulated as a mixed integer quadratic program. The microgrid at Illinois Institute of Technology (IIT) in Chicago, IL was used as a case study. The result of this work reveals the tradeoff faced by the microgrid energy manager between minimizing the risk and minimizing the mean of the total operating cost (TOC) of the microgrid. With this information, the microgrid energy manager can make decisions in the day-ahead and real-time markets according to their risk aversion preference. The assumption of market prices following Gaussian distribution is also verified to be reasonable for the purpose of hedging against their risks. This is done by comparing the result of the proposed formulation with that obtained from the sample market prices randomly generated using the distribution of actual historic market price data.

Biomaterial-based technologies for brain anti-cancer therapeutics and imaging.

PubMed

Orive, G; Ali, O A; Anitua, E; Pedraz, J L; Emerich, D F

2010-08-01

Treating malignant brain tumors represents one of the most formidable challenges in oncology. Contemporary treatment of brain tumors has been hampered by limited drug delivery across the blood-brain barrier (BBB) to the tumor bed. Biomaterials are playing an increasingly important role in developing more effective brain tumor treatments. In particular, polymer (nano)particles can provide prolonged drug delivery directly to the tumor following direct intracerebral injection, by making them physiochemically able to cross the BBB to the tumor, or by functionalizing the material surface with peptides and ligands allowing the drug-loaded material to be systemically administered but still specifically target the tumor endothelium or tumor cells themselves. Biomaterials can also serve as targeted delivery devices for novel therapies including gene therapy, photodynamic therapy, anti-angiogenic and thermotherapy. Nanoparticles also have the potential to play key roles in the diagnosis and imaging of brain tumors by revolutionizing both preoperative and intraoperative brain tumor detection, allowing early detection of pre-cancerous cells, and providing real-time, longitudinal, non-invasive monitoring/imaging of the effects of treatment. Additional efforts are focused on developing biomaterial systems that are uniquely capable of delivering tumor-associated antigens, immunotherapeutic agents or programming immune cells in situ to identify and facilitate immune-mediated tumor cell killing. The continued translation of current research into clinical practice will rely on solving challenges relating to the pharmacology of nanoparticles but it is envisioned that novel biomaterials will ultimately allow clinicians to target tumors and introduce multiple, pharmaceutically relevant entities for simultaneous targeting, imaging, and therapy in a unique and unprecedented manner. Copyright 2010 Elsevier B.V. All rights reserved.

Database for content of mercury in Polish brown coal

NASA Astrophysics Data System (ADS)

Jastrząb, Krzysztof

2018-01-01

Poland is rated among the countries with largest level of mercury emission in Europe. According to information provided by the National Centre for Balancing and Management of Emissions (KOBiZE) more than 10.5 tons of mercury and its compounds were emitted into the atmosphere in 2015 from the area of Poland. Within the scope of the BazaHg project lasting from 2014 to 2015 and co-financed from the National Centre of Research and Development (NCBiR) a database was set up with specification of mercury content in Polish hard steam coal, coking coal and brown coal (lignite) grades. With regard to domestic brown coal the database comprises information on coal grades from Brown Coal Mines of `Bełchatów', `Adamów', `Turów' and `Sieniawa'. Currently the database contains 130 records with parameters of brown coal, where each record stands for technical analysis (content of moisture, ash and volatile particles), elemental analysis (CHNS), content of chlorine and mercury as well as net calorific value and combustion heat. Content of mercury in samples of brown coal grades under test ranged from 44 to 985 μg of Hg/kg with the average level of 345 μg of Hg/kg. The established database makes up a reliable and trustworthy source of information about content of mercury in Polish fossils. The foregoing details completed with information about consumption of coal by individual electric power stations and multiplied by appropriate emission coefficients may serve as the background to establish loads of mercury emitted into atmosphere from individual stations and by the entire sector of power engineering in total. It will also enable Polish central organizations and individual business entities to implement reasonable policy with respect of mercury emission into atmosphere.

Accelerated Performance Testing on the 2006 NCAT Pavement Test Track

DOT National Transportation Integrated Search

2009-12-01

The original National Center for Asphalt Technology (NCAT) Pavement Test Track was built in 2000 in Opelika, Alabama where it has served as a state-of-the-art, full-scale, closed-loop accelerated loading facility. The construction, operation, and res...

Structural evaluation of the historic John A. Roebling suspension bridge.

DOT National Transportation Integrated Search

2003-04-01

he John A. Roebling suspension bridge, formerly the Covington-Cincinnati suspension bridge over the Ohio River was completed in 1867 and is still serving the Northern Kentucky community. The objective of this study is to assess the bridge load capaci...

Metal-shearing energy absorber

NASA Technical Reports Server (NTRS)

Fay, R. J.; Wittrock, E. P.

1971-01-01

Device, consisting of tongue of thin aluminum alloy strip, pull tab, slotted steel plate which serves as cutter, and steel buckle, absorbs mechanical energy when its ends are subjected to tensile loading. Device is applicable as auxiliary shock absorbing anchor for automobile and airplane safety belts.

Data model and relational database design for the New Jersey Water-Transfer Data System (NJWaTr)

USGS Publications Warehouse

Tessler, Steven

2003-01-01

The New Jersey Water-Transfer Data System (NJWaTr) is a database design for the storage and retrieval of water-use data. NJWaTr can manage data encompassing many facets of water use, including (1) the tracking of various types of water-use activities (withdrawals, returns, transfers, distributions, consumptive-use, wastewater collection, and treatment); (2) the storage of descriptions, classifications and locations of places and organizations involved in water-use activities; (3) the storage of details about measured or estimated volumes of water associated with water-use activities; and (4) the storage of information about data sources and water resources associated with water use. In NJWaTr, each water transfer occurs unidirectionally between two site objects, and the sites and conveyances form a water network. The core entities in the NJWaTr model are site, conveyance, transfer/volume, location, and owner. Other important entities include water resource (used for withdrawals and returns), data source, permit, and alias. Multiple water-exchange estimates based on different methods or data sources can be stored for individual transfers. Storage of user-defined details is accommodated for several of the main entities. Many tables contain classification terms to facilitate the detailed description of data items and can be used for routine or custom data summarization. NJWaTr accommodates single-user and aggregate-user water-use data, can be used for large or small water-network projects, and is available as a stand-alone Microsoft? Access database. Data stored in the NJWaTr structure can be retrieved in user-defined combinations to serve visualization and analytical applications. Users can customize and extend the database, link it to other databases, or implement the design in other relational database applications.

Multimodal fusion imaging ensemble for targeted sentinel lymph node management: initial results of an innovative promising approach for anatomically difficult lymphatic drainage in different tumour entities.

PubMed

Maza, Sofiane; Taupitz, Mathias; Taymoorian, Kasra; Winzer, Klaus Jürgen; Rückert, Jens; Paschen, Christian; Räber, Gert; Schneider, Sylke; Trefzer, Uwe; Munz, Dieter L

2007-03-01

There are situations where exact identification and localisation of sentinel lymph nodes (SLNs) are very difficult using lymphoscintigraphy, a hand-held gamma probe and vital dye, either a priori or a posteriori. We developed a new method using a simultaneous injection of two lymphotropic agents for exact topographical tomographic localisation and biopsy of draining SLNs. The purpose of this prospective pilot study was to investigate the feasibility and efficacy of this method ensemble. Fourteen patients with different tumour entities were enrolled. A mixture of (99m)Tc-nanocolloid and a dissolved superparamagnetic iron oxide was injected interstitially. Dynamic, sequential static lymphoscintigraphy and SPECT served as pathfinders. MR imaging was performed 2 h after injection. SPECT, contrast MRI and, if necessary, CT scan data sets were fused and evaluated with special regard to the topographical location of SLNs. The day after injection, nine patients underwent SLN biopsy and, in the presence of SLN metastasis, an elective lymph node dissection. Twenty-five SLNs were localised in the 14 patients examined. A 100% fusion correlation was achieved in all patients. The anatomical sites of SLNs detected during surgery showed 100% agreement with those localised on the multimodal fusion images. SLNs could be excised in 11/14 patients, six of whom had nodal metastasis. Our novel approach of multimodal fusion imaging for targeted SLN management in primary tumours with lymphatic drainage to anatomically difficult regions enables SLN biopsy even in patients with lymphatic drainage to obscure regions. Currently, we are testing its validity in larger patient groups and other tumour entities.

Catatonia as a putative nosological entity: A historical sketch.

PubMed

Gazdag, Gábor; Takács, Rozalia; Ungvari, Gabor S

2017-09-22

Kahlbaum was the first to propose catatonia as a separate disease following the example of general paresis of the insane, which served as a model for establishing a nosological entity. However, Kahlbaum was uncertain about the nosological position of catatonia and considered it a syndrome, or "a temporary stage or a part of a complex picture of various disease forms". Until recently, the issue of catatonia as a separate diagnostic category was not entertained, mainly due to a misinterpretation of Kraepelin's influential views on catatonia as a subtype of schizophrenia. Kraepelin concluded that patients presenting with persistent catatonic symptoms, which he called "genuine catatonic morbid symptoms", particularly including negativism, bizarre mannerisms, and stereotypes, had a poor prognosis similar to those of paranoid and hebephrenic presentations. Accordingly, catatonia was classified as a subtype of dementia praecox/schizophrenia. Despite Kraepelin's influence on psychiatric nosology throughout the 20 th century, there have only been isolated attempts to describe and classify catatonia outside of the Kraepelinian system. For example, the Wernicke-Kleist-Leonhard school attempted to comprehensively elucidate the complexities of psychomotor disturbances associated with major psychoses. However, the Leonhardian categories have never been subjected to the scrutiny of modern investigations. The first three editions of the DSM included the narrow and simplified version of Kraepelin's catatonia concept. Recent developments in catatonia research are reflected in DSM-5, which includes three diagnostic categories: Catatonic Disorder due to Another Medical Condition, Catatonia Associated with another Mental Disorder (Catatonia Specifier), and Unspecified Catatonia. Additionally, the traditional category of catatonic schizophrenia has been deleted. The Unspecified Catatonia category could encourage research exploring catatonia as an independent diagnostic entity.

Catatonia as a putative nosological entity: A historical sketch

PubMed Central

Gazdag, Gábor; Takács, Rozalia; Ungvari, Gabor S

2017-01-01

Kahlbaum was the first to propose catatonia as a separate disease following the example of general paresis of the insane, which served as a model for establishing a nosological entity. However, Kahlbaum was uncertain about the nosological position of catatonia and considered it a syndrome, or “a temporary stage or a part of a complex picture of various disease forms”. Until recently, the issue of catatonia as a separate diagnostic category was not entertained, mainly due to a misinterpretation of Kraepelin’s influential views on catatonia as a subtype of schizophrenia. Kraepelin concluded that patients presenting with persistent catatonic symptoms, which he called “genuine catatonic morbid symptoms”, particularly including negativism, bizarre mannerisms, and stereotypes, had a poor prognosis similar to those of paranoid and hebephrenic presentations. Accordingly, catatonia was classified as a subtype of dementia praecox/schizophrenia. Despite Kraepelin’s influence on psychiatric nosology throughout the 20th century, there have only been isolated attempts to describe and classify catatonia outside of the Kraepelinian system. For example, the Wernicke-Kleist-Leonhard school attempted to comprehensively elucidate the complexities of psychomotor disturbances associated with major psychoses. However, the Leonhardian categories have never been subjected to the scrutiny of modern investigations. The first three editions of the DSM included the narrow and simplified version of Kraepelin’s catatonia concept. Recent developments in catatonia research are reflected in DSM-5, which includes three diagnostic categories: Catatonic Disorder due to Another Medical Condition, Catatonia Associated with another Mental Disorder (Catatonia Specifier), and Unspecified Catatonia. Additionally, the traditional category of catatonic schizophrenia has been deleted. The Unspecified Catatonia category could encourage research exploring catatonia as an independent diagnostic entity. PMID:29043155

Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.

PubMed

Brägelmann, Johannes; Klümper, Niklas; Offermann, Anne; von Mässenhausen, Anne; Böhm, Diana; Deng, Mario; Queisser, Angela; Sanders, Christine; Syring, Isabella; Merseburger, Axel S; Vogel, Wenzel; Sievers, Elisabeth; Vlasic, Ignacija; Carlsson, Jessica; Andrén, Ove; Brossart, Peter; Duensing, Stefan; Svensson, Maria A; Shaikhibrahim, Zaki; Kirfel, Jutta; Perner, Sven

2017-04-01

Purpose: The Mediator complex is a multiprotein assembly, which serves as a hub for diverse signaling pathways to regulate gene expression. Because gene expression is frequently altered in cancer, a systematic understanding of the Mediator complex in malignancies could foster the development of novel targeted therapeutic approaches. Experimental Design: We performed a systematic deconvolution of the Mediator subunit expression profiles across 23 cancer entities ( n = 8,568) using data from The Cancer Genome Atlas (TCGA). Prostate cancer-specific findings were validated in two publicly available gene expression cohorts and a large cohort of primary and advanced prostate cancer ( n = 622) stained by immunohistochemistry. The role of CDK19 and CDK8 was evaluated by siRNA-mediated gene knockdown and inhibitor treatment in prostate cancer cell lines with functional assays and gene expression analysis by RNAseq. Results: Cluster analysis of TCGA expression data segregated tumor entities, indicating tumor-type-specific Mediator complex compositions. Only prostate cancer was marked by high expression of CDK19 In primary prostate cancer, CDK19 was associated with increased aggressiveness and shorter disease-free survival. During cancer progression, highest levels of CDK19 and of its paralog CDK8 were present in metastases. In vitro , inhibition of CDK19 and CDK8 by knockdown or treatment with a selective CDK8/CDK19 inhibitor significantly decreased migration and invasion. Conclusions: Our analysis revealed distinct transcriptional expression profiles of the Mediator complex across cancer entities indicating differential modes of transcriptional regulation. Moreover, it identified CDK19 and CDK8 to be specifically overexpressed during prostate cancer progression, highlighting their potential as novel therapeutic targets in advanced prostate cancer. Clin Cancer Res; 23(7); 1829-40. ©2016 AACR . ©2016 American Association for Cancer Research.

Cluster-based single-sink wireless sensor networks and passive optical network converged network incorporating sideband modulation schemes

NASA Astrophysics Data System (ADS)

Kumar, Love; Sharma, Vishal; Singh, Amarpal

2018-02-01

Wireless sensor networks have tremendous applications, such as civil, military, and environmental monitoring. In most of the applications, sensor data are required to be propagated over the internet/core networks, which result in backhaul setback. Subsequently, there is a necessity to backhaul the sensed information of such networks together with prolonging of the transmission link. Passive optical network (PON) is next-generation access technology emerging as a potential candidate for convergence of the sensed data to the core system. Earlier, the work with single-optical line terminal-PON was demonstrated and investigated merely analytically. This work is an attempt to demonstrate a practical model of a bidirectional single-sink wireless sensor network-PON converged network in which the collected data from cluster heads are transmitted over PON networks. Further, modeled converged structure has been investigated under the influence of double, single, and tandem sideband modulation schemes incorporating a corresponding phase-delay to the sensor data entities that have been overlooked in the past. The outcome illustrates the successful fusion of the sensor data entities over PON with acceptable bit error rate and signal to noise ratio serving as a potential development in the sphere of such converged networks. It has also been revealed that the data entities treated with tandem side band modulation scheme help in improving the performance of the converged structure. Additionally, analysis for uplink transmission reported with queue theory in terms of time cycle, average time delay, data packet generation, and bandwidth utilization. An analytical analysis of proposed converged network shows that average time delay for data packet transmission is less as compared with time cycle delay.

Cell recruiting chemokine-loaded sprayable gelatin hydrogel dressings for diabetic wound healing.

PubMed

Yoon, Dong Suk; Lee, Yunki; Ryu, Hyun Aae; Jang, Yeonsue; Lee, Kyoung-Mi; Choi, Yoorim; Choi, Woo Jin; Lee, Moses; Park, Kyung Min; Park, Ki Dong; Lee, Jin Woo

2016-07-01

In this study, we developed horseradish peroxidase (HRP)-catalyzed sprayable gelatin hydrogels (GH) as a bioactive wound dressing that can deliver cell-attracting chemotactic cytokines to the injured tissues for diabetic wound healing. We hypothesized that topical administration of chemokines using GH hydrogels might improve wound healing by inducing recruitment of the endogenous cells. Two types of chemokines (interleukin-8; IL-8, macrophage inflammatory protein-3α; MIP-3α) were simply loaded into GH hydrogels during in situ cross-linking, and then their wound-healing effects were evaluated in streptozotocin-induced diabetic mice. The incorporation of chemokines did not affect hydrogels properties including swelling ratio and mechanical stiffness, and the bioactivities of IL-8 and MIP-3α released from hydrogel matrices were stably maintained. In vivo transplantation of chemokine-loaded GH hydrogels facilitated cell infiltration into the wound area, and promoted wound healing with enhanced re-epithelialization/neovascularization and increased collagen deposition, compared with no treatment or the GH hydrogel alone. Based on our results, we suggest that cell-recruiting chemokine-loaded GH hydrogel dressing can serve as a delivery platform of various therapeutic proteins for wound healing applications. Despite development of materials combined with therapeutic agents for diabetic wound treatment, impaired wound healing by insufficient chemotactic responses still remain as a significant problem. In this study, we have developed enzyme-catalyzed gelatin (GH) hydrogels as a sprayable dressing material that can deliver cell-attracting chemokines for diabetic wound healing. The chemotactic cytokines (IL-8 and MIP-3α) were simply loaded within hydrogel during in situ gelling, and wound healing efficacy of chemokine-loaded GH hydrogels was investigated in STZ-induced diabetic mouse model. These hydrogels significantly promoted wound-healing efficacy with faster wound closure, neovascularization, and thicker granulation. Therefore, we expect that HRP-catalyzed in situ forming GH hydrogels can serve as an injectable/sprayable carrier of various therapeutic agents for wound healing applications. Copyright © 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Identification of dynamic load for prosthetic structures.

PubMed

Zhang, Dequan; Han, Xu; Zhang, Zhongpu; Liu, Jie; Jiang, Chao; Yoda, Nobuhiro; Meng, Xianghua; Li, Qing

2017-12-01

Dynamic load exists in numerous biomechanical systems, and its identification signifies a critical issue for characterizing dynamic behaviors and studying biomechanical consequence of the systems. This study aims to identify dynamic load in the dental prosthetic structures, namely, 3-unit implant-supported fixed partial denture (I-FPD) and teeth-supported fixed partial denture. The 3-dimensional finite element models were constructed through specific patient's computerized tomography images. A forward algorithm and regularization technique were developed for identifying dynamic load. To verify the effectiveness of the identification method proposed, the I-FPD and teeth-supported fixed partial denture structures were investigated to determine the dynamic loads. For validating the results of inverse identification, an experimental force-measuring system was developed by using a 3-dimensional piezoelectric transducer to measure the dynamic load in the I-FPD structure in vivo. The computationally identified loads were presented with different noise levels to determine their influence on the identification accuracy. The errors between the measured load and identified counterpart were calculated for evaluating the practical applicability of the proposed procedure in biomechanical engineering. This study is expected to serve as a demonstrative role in identifying dynamic loading in biomedical systems, where a direct in vivo measurement may be rather demanding in some areas of interest clinically. Copyright © 2017 John Wiley & Sons, Ltd.

Optimization, formulation, and characterization of multiflavonoids-loaded flavanosome by bulk or sequential technique

PubMed Central

Karthivashan, Govindarajan; Masarudin, Mas Jaffri; Kura, Aminu Umar; Abas, Faridah; Fakurazi, Sharida

2016-01-01

This study involves adaptation of bulk or sequential technique to load multiple flavonoids in a single phytosome, which can be termed as “flavonosome”. Three widely established and therapeutically valuable flavonoids, such as quercetin (Q), kaempferol (K), and apigenin (A), were quantified in the ethyl acetate fraction of Moringa oleifera leaves extract and were commercially obtained and incorporated in a single flavonosome (QKA–phosphatidylcholine) through four different methods of synthesis – bulk (M1) and serialized (M2) co-sonication and bulk (M3) and sequential (M4) co-loading. The study also established an optimal formulation method based on screening the synthesized flavonosomes with respect to their size, charge, polydispersity index, morphology, drug–carrier interaction, antioxidant potential through in vitro 1,1-diphenyl-2-picrylhydrazyl kinetics, and cytotoxicity evaluation against human hepatoma cell line (HepaRG). Furthermore, entrapment and loading efficiency of flavonoids in the optimal flavonosome have been identified. Among the four synthesis methods, sequential loading technique has been optimized as the best method for the synthesis of QKA–phosphatidylcholine flavonosome, which revealed an average diameter of 375.93±33.61 nm, with a zeta potential of −39.07±3.55 mV, and the entrapment efficiency was >98% for all the flavonoids, whereas the drug-loading capacity of Q, K, and A was 31.63%±0.17%, 34.51%±2.07%, and 31.79%±0.01%, respectively. The in vitro 1,1-diphenyl-2-picrylhydrazyl kinetics of the flavonoids indirectly depicts the release kinetic behavior of the flavonoids from the carrier. The QKA-loaded flavonosome had no indication of toxicity toward human hepatoma cell line as shown by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide result, wherein even at the higher concentration of 200 µg/mL, the flavonosomes exert >85% of cell viability. These results suggest that sequential loading technique may be a promising nanodrug delivery system for loading multiflavonoids in a single entity with sustained activity as an antioxidant, hepatoprotective, and hepatosupplement candidate. PMID:27555765

Optimization, formulation, and characterization of multiflavonoids-loaded flavanosome by bulk or sequential technique.

PubMed

Karthivashan, Govindarajan; Masarudin, Mas Jaffri; Kura, Aminu Umar; Abas, Faridah; Fakurazi, Sharida

2016-01-01

This study involves adaptation of bulk or sequential technique to load multiple flavonoids in a single phytosome, which can be termed as "flavonosome". Three widely established and therapeutically valuable flavonoids, such as quercetin (Q), kaempferol (K), and apigenin (A), were quantified in the ethyl acetate fraction of Moringa oleifera leaves extract and were commercially obtained and incorporated in a single flavonosome (QKA-phosphatidylcholine) through four different methods of synthesis - bulk (M1) and serialized (M2) co-sonication and bulk (M3) and sequential (M4) co-loading. The study also established an optimal formulation method based on screening the synthesized flavonosomes with respect to their size, charge, polydispersity index, morphology, drug-carrier interaction, antioxidant potential through in vitro 1,1-diphenyl-2-picrylhydrazyl kinetics, and cytotoxicity evaluation against human hepatoma cell line (HepaRG). Furthermore, entrapment and loading efficiency of flavonoids in the optimal flavonosome have been identified. Among the four synthesis methods, sequential loading technique has been optimized as the best method for the synthesis of QKA-phosphatidylcholine flavonosome, which revealed an average diameter of 375.93±33.61 nm, with a zeta potential of -39.07±3.55 mV, and the entrapment efficiency was >98% for all the flavonoids, whereas the drug-loading capacity of Q, K, and A was 31.63%±0.17%, 34.51%±2.07%, and 31.79%±0.01%, respectively. The in vitro 1,1-diphenyl-2-picrylhydrazyl kinetics of the flavonoids indirectly depicts the release kinetic behavior of the flavonoids from the carrier. The QKA-loaded flavonosome had no indication of toxicity toward human hepatoma cell line as shown by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide result, wherein even at the higher concentration of 200 µg/mL, the flavonosomes exert >85% of cell viability. These results suggest that sequential loading technique may be a promising nanodrug delivery system for loading multiflavonoids in a single entity with sustained activity as an antioxidant, hepatoprotective, and hepatosupplement candidate.

Microgrid optimized resource dispatch for public-purpose resiliency and sustainability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burr, Michael; Camilleri, John; Lubkeman, David

Communities in Atlantic coastal regions have in recent years sought to improve the resiliency of their critical infrastructure and public services, especially to protect against hurricanes and other events capable of causing widespread damage and disruption. As the backbone of any community’s critical functions, the electricity distribution system requires high resiliency in order to maintain local energy delivery services. Against this backdrop, the Project sought to develop a resilient energy microgrid control system capable of integrating distributed renewable energy resources, natural gas CHP units, energy storage, and demand-side management technologies in near-real-time optimization schemes for the community of Olney, Md.more » The Montgomery County Planning Board in 2005 established the Olney Town Center area as a “civic center/town commons,” in part because it serves as a key point of interaction in the community – but also because it contains numerous vital community assets. With a total peak electrical load of about 8 MW (including Montgomery General Hospital with a 2.4 MW peak), the Project area is a business and essential services area, directly serving a suburban population of more than 33,000 residents. It contains a hospital, police station, two fire stations, two schools, grocery stores, and gas stations, and the community’s water tower, among other things. Moreover, the location stands at the crossroads of two state highways that represent major regional arteries for commerce and public safety in Montgomery County. These characteristics made the Project area an appropriate setting for considering microgrid deployment. It presented a model of a typical Maryland suburban community, with geographic dispersion of vital assets over a sizeable area, and a combination of overhead distribution lines and underground cables serving those critical loads. Such a representative model helped to ensure the solutions developed and the scenarios tested would be readily applicable to other communities in the state and the region. Further, the Project’s outcomes and lessons provide insights to guide community microgrid design and development in many locations. To achieve Project objectives – including those established by the U.S. Department of Energy (DOE) National Energy Technology Laboratory – the Project team researched, developed, and tested in simulation a set of microgrid controls capable of maintaining electricity supplies for critical community loads in the event of a regional utility outage lasting many days or even weeks. Testing and analysis showed that the microgrid would be capable of maintaining electricity supply to critical loads essentially indefinitely in most outage scenarios, while also substantially improving overall reliability for microgrid customers. With targeted improvements in local utility distribution infrastructure, test analysis showed that the microgrid would be capable of reducing annual electricity outages for critical loads by 98%. Further, to help achieve environmental and efficiency policy goals established by both the State of Maryland and the federal government, the team designed the system to reduce the annual carbon footprint of served loads by 20%, and to improve system energy efficiency for those loads by at least 20%. Testing showed that, as designed, the system is capable of meeting these performance requirements, with potential for further improvements through more effective thermal energy utilization. This Final Report, comprised of four volumes and 11 annexes, presents the results of these project efforts, including feasibility assessment (section F) and guidance for decision-makers considering prospective deployment of public-purpose microgrid systems in Maryland communities.« less

Developing microRNA therapeutics.

PubMed

van Rooij, Eva; Purcell, Angela L; Levin, Arthur A

2012-02-03

Rarely a new research area has gotten such an overwhelming amount of attention as have microRNAs. Although several basic questions regarding their biological principles still remain to be answered, many specific characteristics of microRNAs in combination with compelling therapeutic efficacy data and a clear involvement in human disease have triggered the biotechnology community to start exploring the possibilities of viewing microRNAs as therapeutic entities. This review serves to provide some general insight into some of the current microRNAs targets, how one goes from the initial bench discovery to actually developing a therapeutically useful modality, and will briefly summarize the current patent landscape and the companies that have started to explore microRNAs as the next drug target.

The NASA Air Traffic Management Ontology: Technical Documentation

NASA Technical Reports Server (NTRS)

Keller, Richard M.

2017-01-01

This document is intended to serve as comprehensive documentation for the NASA Air Traffic Management (ATM) Ontology. The ATM Ontology is a conceptual model that defines key classes of entities and relationships pertaining to the US National Airspace System (NAS) and the management of air traffic through that system. A wide variety of classes are represented in the ATM Ontology, including classes corresponding to flights, aircraft, manufacturers, airports, airlines, air routes, NAS facilities, air traffic control advisories, weather phenomena, and many others. The Ontology can be useful in the context of a variety of information management tasks relevant to NAS, including information exchange, data query and search, information organization, information integration, and terminology standardization.

American Indian tribal taxation of energy resources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Redhorse, D.; Smith, T.R.

1982-07-01

Whether a tribe can tax is now but old rhetoric. How to tax has become the more crucial question. Tribes must develop taxing schemes that are reasonable and competitive. How public services are linked to taxation, as well as who are the recipients of those services, is weighed heavily in considering whether other taxing entities interfere with tribal governments. The Merrion Decision, which upheld the authority of a tribe to impose taxes on minerals extracted from tribal lands, serves as a milestone in Indian taxation; however, the decision itself pointed to possible pitfalls unless tribes judiciously exercise judgement in theirmore » use of the power to tax. 39 references.« less

Hydro pumped storage, international experience: An overview of ASCE task committee report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Makarechian, A.H.; Rummel, G.

1995-12-31

This paper presents an overview of a report that is being prepared by ASCE Task Committee on Pumped Storage, International Experience. The reader is referred to the committee report that will be available in 1996. Many pumped storage projects in Europe, but particularly in Japan are becoming an indispensable resource in management of loads and resources on the electrical system. They serve to enhance reliability of the system and to provide for efficient utilization of thermal resources. Pumped storage is increasingly being used as a system management tool. To serve such purposes and to function in this key role, pumpedmore » storage projects are designed for very fast loading and unloading, for very fast mode reversals from pumping to generating and visa versa, for synchronous generation, and more importantly for load ramping during the pumping mode. This is achieved by use of variable-speed pump turbine units. The use of variable-speed units has proven so successful in Japan that many older projects are retrofitted with this new feature. Other interesting equipment applications are discussed including utilization of multi-stage unregulated pump turbines for very high heads (up to 1,250 m), and continued extension of the experience for high head reversible Francis unit, currently in excess of 750 m.« less

Sediment data sources and estimated annual suspended-sediment loads of rivers and streams in Colorado

USGS Publications Warehouse

Elliott, J.G.; DeFeyter, K.L.

1986-01-01

Sources of sediment data collected by several government agencies through water year 1984 are summarized for Colorado. The U.S. Geological Survey has collected suspended-sediment data at 243 sites; these data are stored in the U.S. Geological Survey 's water data storage and retrieval system. The U.S. Forest Service has collected suspended-sediment and bedload data at an additional 225 sites, and most of these data are stored in the U.S. Environmental Protection Agency 's water-quality-control information system. Additional unpublished sediment data are in the possession of the collecting entities. Annual suspended-sediment loads were computed for 133 U.S. Geological Survey sediment-data-collection sites using the daily mean water-discharge/sediment-transport-curve method. Sediment-transport curves were derived for each site by one of three techniques: (1) Least-squares linear regression of all pairs of suspended-sediment and corresponding water-discharge data, (2) least-squares linear regression of data sets subdivided on the basis of hydrograph season; and (3) graphical fit to a logarithm-logarithm plot of data. The curve-fitting technique used for each site depended on site-specific characteristics. Sediment-data sources and estimates of annual loads of suspended, bed, and total sediment from several other reports also are summarized. (USGS)

Cogeneration feasibility: Otis Elevator Company and Polychrome Corporation. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1982-05-01

The purpose of this study was to assess the feasibility of cogeneration at Otis Elevator Company and Polychrome Corporation located in Westchester County, New York. Each plant and its associated thermal and electrical load is reviewed. Three basic cycles for the cogeneration are investigated: power only, power generation with waste heat recovery, and combined cycle. Each case was assessed economically, beginning with a screening method to suggest those configurations most likely to be implemented and continuing through an assessment of the regulatory environment for cogeneration and an analysis of rate structures for buy back power, displaced power, and supplementing service.more » It is concluded that: for a plant designed to supply the combined loads of the two corporations, interconnection costs coupled to the coincidence of load result in unfavorable economics; for separate cogeneration plants, owned and operated by each individual corporation, energy consumption patterns and the current regulatory environment, in particular the existing and proposed cogeneration system rate structures, do not permit viable economics for the proposed plants; but if the proposed cycle were owned and operated by a new entity (neither Otis/Polychrome nor the utility), an economic scheme with marginal financial benefits can be developed and may be worthy of further study. (LEW)« less

Bidding strategy for microgrid in day-ahead market based on hybrid stochastic/robust optimization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Guodong; Xu, Yan; Tomsovic, Kevin

In this paper, we propose an optimal bidding strategy in the day-ahead market of a microgrid consisting of intermittent distributed generation (DG), storage, dispatchable DG and price responsive loads. The microgrid coordinates the energy consumption or production of its components and trades electricity in both the day-ahead and real-time markets to minimize its operating cost as a single entity. The bidding problem is challenging due to a variety of uncertainties, including power output of intermittent DG, load variation, day-ahead and real-time market prices. A hybrid stochastic/robust optimization model is proposed to minimize the expected net cost, i.e., expected total costmore » of operation minus total benefit of demand. This formulation can be solved by mixed integer linear programming. The uncertain output of intermittent DG and day-ahead market price are modeled via scenarios based on forecast results, while a robust optimization is proposed to limit the unbalanced power in real-time market taking account of the uncertainty of real-time market price. Numerical simulations on a microgrid consisting of a wind turbine, a PV panel, a fuel cell, a micro-turbine, a diesel generator, a battery and a responsive load show the advantage of stochastic optimization in addition to robust optimization.« less

Bidding strategy for microgrid in day-ahead market based on hybrid stochastic/robust optimization

DOE PAGES

Liu, Guodong; Xu, Yan; Tomsovic, Kevin

2016-01-01

In this paper, we propose an optimal bidding strategy in the day-ahead market of a microgrid consisting of intermittent distributed generation (DG), storage, dispatchable DG and price responsive loads. The microgrid coordinates the energy consumption or production of its components and trades electricity in both the day-ahead and real-time markets to minimize its operating cost as a single entity. The bidding problem is challenging due to a variety of uncertainties, including power output of intermittent DG, load variation, day-ahead and real-time market prices. A hybrid stochastic/robust optimization model is proposed to minimize the expected net cost, i.e., expected total costmore » of operation minus total benefit of demand. This formulation can be solved by mixed integer linear programming. The uncertain output of intermittent DG and day-ahead market price are modeled via scenarios based on forecast results, while a robust optimization is proposed to limit the unbalanced power in real-time market taking account of the uncertainty of real-time market price. Numerical simulations on a microgrid consisting of a wind turbine, a PV panel, a fuel cell, a micro-turbine, a diesel generator, a battery and a responsive load show the advantage of stochastic optimization in addition to robust optimization.« less

Button fixation technique for Achilles tendon reinsertion: a biomechanical study.

PubMed

Awogni, David; Chauvette, Guillaume; Lemieux, Marie-Line; Balg, Frédéric; Langelier, Ève; Allard, Jean-Pascal

2014-01-01

Chronic insertional tendinopathy of the Achilles tendon is a frequent and disabling pathologic entity. Operative treatment is indicated for patients for whom nonoperative management has failed. The treatment can consist of the complete detachment of the tendon insertion and extensive debridement. We biomechanically tested a new operative technique that uses buttons for fixation of the Achilles tendon insertion on the posterior calcaneal tuberosity and compared it with 2 standard bone anchor techniques. A total of 40 fresh-frozen cadaver specimens were used to compare 3 fixation techniques for reinserting the Achilles tendon: single row anchors, double row anchors, and buttons. The ultimate loads and failure mechanisms were recorded. The button assembly (median load 764 N, range 713 to 888) yielded a median fixation strength equal to 202% (range 137% to 251%) of that obtained with the double row anchors (median load 412 N, range 301 to 571) and 255% (range 213% to 317%) of that obtained with the single row anchors (median load 338 N, range 241 to 433N). The most common failure mechanisms were suture breakage with the buttons (55%) and pull out of the implant with the double row (70%) and single row (85%) anchors. The results of the present biomechanical cadaver study have shown that Achilles tendon reinsertion fixation using the button technique provides superior pull out strength than the bone anchors tested. Copyright © 2014 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.

LispSEI: The Programmer’s Manual

DTIC Science & Technology

1988-01-01

defun print-entities ( str entities etype) (format t str ) (dolist (entity entities) (format t " -A" (entity-name entity *type)))) (detun entity-name...fields are munged only after the filters are executed. This makes things much easier. ;:Algorithm: (1) get initial list. (2) take out those entitles which...don’t meet all the constraints. 1, 3) pass the entities list through all the filters.(4) munge the appropriate fields (5)u return the result. (defn s

Structural optimization of 3D-printed synthetic spider webs for high strength

PubMed Central

Qin, Zhao; Compton, Brett G.; Lewis, Jennifer A.; Buehler, Markus J.

2015-01-01

Spiders spin intricate webs that serve as sophisticated prey-trapping architectures that simultaneously exhibit high strength, elasticity and graceful failure. To determine how web mechanics are controlled by their topological design and material distribution, here we create spider-web mimics composed of elastomeric filaments. Specifically, computational modelling and microscale 3D printing are combined to investigate the mechanical response of elastomeric webs under multiple loading conditions. We find the existence of an asymptotic prey size that leads to a saturated web strength. We identify pathways to design elastomeric material structures with maximum strength, low density and adaptability. We show that the loading type dictates the optimal material distribution, that is, a homogeneous distribution is better for localized loading, while stronger radial threads with weaker spiral threads is better for distributed loading. Our observations reveal that the material distribution within spider webs is dictated by the loading condition, shedding light on their observed architectural variations. PMID:25975372

POSTOP: Postbuckled open-stiffener optimum panels-theory and capability

NASA Technical Reports Server (NTRS)

Dickson, J. N.; Biggers, S. B.

1984-01-01

The computer program POSTOP was developed to serve as an aid in the analysis and sizing of stiffened composite panels that are loaded in the postbuckling regime. A comprehensive set of analysis routines was coupled to a widely used optimization program to produce this sizing code. POSTOP is intended for the preliminary design of metal or composite panels with open-section stiffeners, subjected to multiple combined biaxial compression (or tension), shear and normal pressure load cases. Longitudinal compression, however, is assumed to be the dominant loading. Temperature, initial bow eccentricity and load eccentricity effects are included. The panel geometry is assumed to be repetitive over several bays in the longitudinal (stiffener) direction as well as in the transverse direction. Analytical routines are included to compute panel stiffnesses, strains, local and panel buckling loads, and skin/stiffener interface stresses. The resulting program is applicable to stiffened panels as commonly used in fuselage, wing, or empennage structures. The analysis procedures and rationale for the assumptions used therein are described in detail.

Tunable actuation of dielectric elastomer by electromechanical loading rates

NASA Astrophysics Data System (ADS)

Li, Guorui; Zhang, Mingqi; Chen, Xiangping; Yang, Xuxu; Wong, Tuck-Whye; Li, Tiefeng; Huang, Zhilong

2017-10-01

Dielectric elastomer (DE) membranes are able to self-deform with the application of an electric field through the thickness direction. In comparison to conventional rigid counterparts, soft actuators using DE provide a variety of advantages such as high compliance, low noise, and light weight. As one of the challenges in the development of DE actuating devices, tuning the electromechanical actuating behavior is crucial in order to achieve demanded loading paths and to avoid electromechanical failures. In this paper, our experimental results show that the electromechanical loading conditions affect the actuating behaviors of the DE. The electrical actuating force can be tuned by 29.4% with the control of the electrical charging rate. In addition, controllable actuations have been investigated by the mechanical model in manipulating the electromechanical loading rate. The calculated results agree well with the experimental data. Lastly, it is believed that the mechanisms of controlling the electromechanical loading rate may serve as a guide for the design of DE devices and high performance soft robots in the near future.

Experimental study of thermo-mechanical behavior of a thermosetting shape-memory polymer

NASA Astrophysics Data System (ADS)

Liu, Ruoxuan; Li, Yunxin; Liu, Zishun

2018-01-01

The thermo-mechanical behavior of shape-memory polymers (SMPs) serves for the engineering applications of SMPs. Therefore the understanding of thermo-mechanical behavior of SMPs is of great importance. This paper investigates the influence of loading rate and loading level on the thermo-mechanical behavior of a thermosetting shape-memory polymer through experimental study. A series of cyclic tension tests and shape recovery tests at different loading conditions are performed to study the strain level and strain rate effect. The results of tension tests show that the thermosetting shape-memory polymer will behave as rubber material at temperature lower than the glass transition temperature (Tg) and it can obtain a large shape fix ratio at cyclic loading condition. The shape recovery tests exhibit that loading rate and loading level have little effect on the beginning and ending of shape recovery process of the thermosetting shape-memory polymer. Compared with the material which is deformed at temperature higher than Tg, the material deformed at temperature lower than Tg behaves a bigger recovery speed.

Identifying Factors that Influence Expression of Eutrophication in a Central California Estuary

EPA Science Inventory

Coastal eutrophication models have proposed that various environmental conditions can serve as filters mediating the effects of nutrient loading on coastal ecosystems. Variation in such filters due to natural or anthropogenic causes can potentially lead to varied responses in ove...

49 CFR 193.2155 - Structural requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) The imposed loading from— (i) Full hydrostatic head of impounded LNG; (ii) Hydrodynamic action... forces from a credible opening in the component or item served, assuming that the discharge pressure equals design pressure. (2) The erosive action from a spill, including jetting of spilling LNG, and any...

49 CFR 193.2155 - Structural requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) The imposed loading from— (i) Full hydrostatic head of impounded LNG; (ii) Hydrodynamic action... forces from a credible opening in the component or item served, assuming that the discharge pressure equals design pressure. (2) The erosive action from a spill, including jetting of spilling LNG, and any...

49 CFR 193.2155 - Structural requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) The imposed loading from— (i) Full hydrostatic head of impounded LNG; (ii) Hydrodynamic action... forces from a credible opening in the component or item served, assuming that the discharge pressure equals design pressure. (2) The erosive action from a spill, including jetting of spilling LNG, and any...

49 CFR 193.2155 - Structural requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) The imposed loading from— (i) Full hydrostatic head of impounded LNG; (ii) Hydrodynamic action... forces from a credible opening in the component or item served, assuming that the discharge pressure equals design pressure. (2) The erosive action from a spill, including jetting of spilling LNG, and any...

49 CFR 193.2155 - Structural requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) The imposed loading from— (i) Full hydrostatic head of impounded LNG; (ii) Hydrodynamic action... forces from a credible opening in the component or item served, assuming that the discharge pressure equals design pressure. (2) The erosive action from a spill, including jetting of spilling LNG, and any...

Demonstrating NaradaBrokering as a Middleware Fabric for Grid-based Remote Visualization Services

NASA Astrophysics Data System (ADS)

Pallickara, S.; Erlebacher, G.; Yuen, D.; Fox, G.; Pierce, M.

2003-12-01

Remote Visualization Services (RVS) have tended to rely on approaches based on the client server paradigm. Here we demonstrate our approach - based on a distributed brokering infrastructure, NaradaBrokering [1] - that relies on distributed, asynchronous and loosely coupled interactions to meet the requirements and constraints of RVS. In our approach to RVS, services advertise their capabilities to the broker network that manages these service advertisements. Among the services considered within our system are those that perform graphic transformations, mediate access to specialized datasets and finally those that manage the execution of specified tasks. There could be multiple instances of each of these services and the system ensures that load for a given service is distributed efficiently over these service instances. We will demonstrate implementation of concepts that we outlined in the oral presentation. This would involve two or more visualization servers interacting asynchronously with multiple clients through NaradaBrokering. The communicating entities may exchange SOAP [2] (Simple Object Access Protocol) messages. SOAP is a lightweight protocol for exchange of information in a decentralized, distributed environment. It is an XML based protocol that consists of three parts: an envelope that describes what is in a message and how to process it, rules for expressing instances of application-defined data types, and a convention for representing remote invocation related operations. Furthermore, we will also demonstrate how clients can retrieve their results after prolonged disconnects or after any failures that might have taken place. The entities, services and clients alike, are not limited by the geographical distances that separate them. We are planning to test this system in the context of trans-Atlantic links separating interacting entities. {[1]} The NaradaBrokering Project: http://www.naradabrokering.org {[2]} Newcomer, E., 2002, Understanding web services: XML, WSDL, SOAP, and UDDI, Addison Wesley Professional.

Hereditary and non-hereditary microangiopathies in the young. An up-date.

PubMed

Ringelstein, E Bernd; Kleffner, Ilka; Dittrich, Ralf; Kuhlenbäumer, Gregor; Ritter, Martin A

2010-12-15

In recent years, a considerable number of new sporadic or hereditary small artery diseases of the brain have been detected which preferably occur in younger age, below 45 years. Cerebral microangiopathies constitute an appreciable portion of all strokes. In middle aged patients, hereditary cerebral small vessel diseases have to be separated from sporadic degenerative cerebral microangiopathy which is mainly due to a high vascular risk load. Features of the following disorders and details how to differentiate them, are reviewed here, namely CADASIL, MELAS, AD-RVLC, HEMID, CARASIL, PADMAL, FABRY, COL4A1-related cerebral small vessel diseases and a Portuguese type of autosomal dominant cerebral small vessel disease (SVDB). The symptomatic overlap of the cerebral microangiopathies include also other distinctive non-hereditary diseases like posterior (reversible) encephalopathy and Susac's syndrome which are also described. Some of the microangiopathies described here are not only seen in the young but also in the elderly. The precise diagnosis has direct therapeutic implications in several of these entities. Cerebral microangiopathies cause recurring strokes and diffuse white matter lesions leading to a broad spectrum of gait disturbances and in most of these disorders cognitive impairment or even vascular dementia in the long term. Often, they also involve the eye, the inner ear or the kidney. Several typical imaging findings from illustrative cases are presented. The order in which these diseases are presented here is not dictated by an inner logic principle, because a genetically or pathophysiologically based classification system of all these entities does not exist yet. Some entities are well established and not unusual, whereas others have only been described in a few cases in total. Copyright © 2010 Elsevier B.V. All rights reserved.

Predictive Techniques for Spacecraft Cabin Air Quality Control

NASA Technical Reports Server (NTRS)

Perry, J. L.; Cromes, Scott D. (Technical Monitor)

2001-01-01

As assembly of the International Space Station (ISS) proceeds, predictive techniques are used to determine the best approach for handling a variety of cabin air quality challenges. These techniques use equipment offgassing data collected from each ISS module before flight to characterize the trace chemical contaminant load. Combined with crew metabolic loads, these data serve as input to a predictive model for assessing the capability of the onboard atmosphere revitalization systems to handle the overall trace contaminant load as station assembly progresses. The techniques for predicting in-flight air quality are summarized along with results from early ISS mission analyses. Results from groundbased analyses of in-flight air quality samples are compared to the predictions to demonstrate the technique's relative conservatism.

Microgrids for Service Restoration to Critical Load in a Resilient Distribution System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xu, Yin; Liu, Chen-Ching; Schneider, Kevin P.

icrogrids can act as emergency sources to serve critical loads when utility power is unavailable. This paper proposes a resiliency-based methodology that uses microgrids to restore critical loads on distribution feeders after a major disaster. Due to limited capacity of distributed generators (DGs) within microgrids, dynamic performance of the DGs during the restoration process becomes essential. In this paper, the stability of microgrids, limits on frequency deviation, and limits on transient voltage and current of DGs are incorporated as constraints of the critical load restoration problem. The limits on the amount of generation resources within microgrids are also considered. Bymore » introducing the concepts of restoration tree and load group, restoration of critical loads is transformed into a maximum coverage problem, which is a linear integer program (LIP). The restoration paths and actions are determined for critical loads by solving the LIP. A 4-feeder, 1069-bus unbalanced test system with four microgrids is utilized to demonstrate the effectiveness of the proposed method. The method is applied to the distribution system in Pullman, WA, resulting in a strategy that uses generators on the Washington State University campus to restore service to the Hospital and City Hall in Pullman.« less

Characterization of carrier erythrocytes for biosensing applications

NASA Astrophysics Data System (ADS)

Bustamante López, Sandra C.; Meissner, Kenith E.

2017-09-01

Erythrocyte abundance, mobility, and carrying capacity make them attractive as a platform for blood analyte sensing as well as for drug delivery. Sensor-loaded erythrocytes, dubbed erythrosensors, could be reinfused into the bloodstream, excited noninvasively through the skin, and used to provide measurement of analyte levels in the bloodstream. Several techniques to load erythrocytes, thus creating carrier erythrocytes, exist. However, their cellular characteristics remain largely unstudied. Changes in cellular characteristics lead to removal from the bloodstream. We hypothesize that erythrosensors need to maintain native erythrocytes' (NEs) characteristics to serve as a long-term sensing platform. Here, we investigate two loading techniques and the properties of the resulting erythrosensors. For loading, hypotonic dilution requires a hypotonic solution while electroporation relies on electrical pulses to perforate the erythrocyte membrane. We analyze the resulting erythrosensor signal, size, morphology, and hemoglobin content. Although the resulting erythrosensors exhibit morphological changes, their size was comparable with NEs. The hypotonic dilution technique was found to load erythrosensors much more efficiently than electroporation, and the sensors were loaded throughout the volume of the erythrosensors. Finally, both techniques resulted in significant loss of hemoglobin. This study points to the need for continued development of loading techniques that better preserve NE characteristics.

75 FR 48625 - Amendment to the International Traffic in Arms Regulations: Dual Nationals and Third-Country...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-11

..., including technical data, within a foreign business entity, foreign governmental entity, or international..., directly employed by the foreign business entity, foreign governmental entity, or international... any defense article, any foreign business entity, foreign governmental entity, or international...

Cellular and molecular mechanisms for the bone response to mechanical loading

NASA Technical Reports Server (NTRS)

Bloomfield, S. A.

2001-01-01

To define the cellular and molecular mechanisms for the osteogenic response of bone to increased loading, several key steps must be defined: sensing of the mechanical signal by cells in bone, transduction of the mechanical signal to a biochemical one, and transmission of that biochemical signal to effector cells. Osteocytes are likely to serve as sensors of loading, probably via interstitial fluid flow produced during loading. Evidence is presented for the role of integrins, the cell's actin cytoskeleton, G proteins, and various intracellular signaling pathways in transducing that mechanical signal to a biochemical one. Nitric oxide, prostaglandins, and insulin-like growth factors all play important roles in these pathways. There is growing evidence for modulation of these mechanotransduction steps by endocrine factors, particularly parathyroid hormone and estrogen. The efficiency of this process is also impaired in the aged animal, yet what remains undefined is at what step mechanotransduction is affected.

Assessment of thermal loads in the CERN SPS crab cavities cryomodule1

NASA Astrophysics Data System (ADS)

Carra, F.; Apeland, J.; Calaga, R.; Capatina, O.; Capelli, T.; Verdú-Andrés, S.; Zanoni, C.

2017-07-01

As a part of the HL-LHC upgrade, a cryomodule is designed to host two crab cavities for a first test with protons in the SPS machine. The evaluation of the cryomodule heat loads is essential to dimension the cryogenic infrastructure of the system. The current design features two cryogenic circuits. The first circuit adopts superfluid helium at 2 K to maintain the cavities in the superconducting state. The second circuit, based on helium gas at a temperature between 50 K and 70 K, is connected to the thermal screen, also serving as heat intercept for all the interfaces between the cold mass and the external environment. An overview of the heat loads to both circuits, and the combined numerical and analytical estimations, is presented. The heat load of each element is detailed for the static and dynamic scenarios, with considerations on the design choices for the thermal optimization of the most critical components.

Unsteady hydraulic simulation of the cavitating part load vortex rope in Francis turbines

NASA Astrophysics Data System (ADS)

Brammer, J.; Segoufin, C.; Duparchy, F.; Lowys, P. Y.; Favrel, A.; Avellan, F.

2017-04-01

For Francis turbines at part load operation a helical vortex rope is formed due to the swirling nature of the flow exiting the runner. This vortex creates pressure fluctuations which can lead to power swings, and the unsteady loading can lead to fatigue damage of the runner. In the case that the vortex rope cavitates there is the additional risk that hydro-acoustic resonance can occur. It is therefore important to be able to accurately simulate this phenomenon to address these issues. In this paper an unsteady, multi-phase CFD model was used to simulate two part-load operating points, for two different cavitation conditions. The simulation results were validated with test-rig data, and showed very good agreement. These results also served as an input for FEA calculations and fatigue analysis, which are presented in a separate study.

Effects of foot orthoses on Achilles tendon load in recreational runners.

PubMed

Sinclair, J; Isherwood, J; Taylor, P J

2014-09-01

Achilles tendon pathology is a frequently occurring musculoskeletal disorder in runners. Foot orthoses have been shown to reduce the symptoms of pain in runners but their mechanical effects are still not well understood. This study aimed to examine differences in Achilles tendon load when running with and without orthotic intervention. Twelve male runners ran at 4.0 m·s(-1). Ankle joint moments and Achilles tendon forces were compared when running with and without orthotics. The results indicate that running with foot orthotics was associated with significant reductions in Achilles tendon load compared to without orthotics. In addition to providing insight into the mechanical effects of orthotics in runners, the current investigation suggests that via reductions in Achilles tendon load, foot orthoses may serve to reduce the incidence of chronic Achilles tendon pathologies in runners. Copyright © 2014 Elsevier Ltd. All rights reserved.

Fluorescent polymeric micelles with aggregation-induced emission properties for monitoring the encapsulation of doxorubicin.

PubMed

Chen, Jen-Ing; Wu, Wen-Chung

2013-05-01

A new type of fluorescent polymeric micelles is developed by self-assembly from a series of amphiphilic block copolymers, poly(ethylene glycol)-b-poly[styrene-co-(2-(1,2,3,4,5-pentaphenyl-1H-silol-1-yloxy)ethyl methacrylate)] [PEG-b-P(S-co-PPSEMA)]. Their capability of loading doxorubicin (DOX) is investigated by monitoring the loading content, encapsulation efficiency, and photophysical properties of micelles. Förster resonance energy transfer from PPSEMA to DOX is observed in DOX-loaded micelles, which can serve as an indication of successful encapsulation of DOX in these micelles. The application of this new type of fluorescent polymeric micelles as a fluorescent probe and an anticancer drug carrier simultaneously is explored by studying the intracellular uptake of DOX-loaded micelles. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Comparison of Wind Power and Load Forecasting Error Distributions: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hodge, B. M.; Florita, A.; Orwig, K.

2012-07-01

The introduction of large amounts of variable and uncertain power sources, such as wind power, into the electricity grid presents a number of challenges for system operations. One issue involves the uncertainty associated with scheduling power that wind will supply in future timeframes. However, this is not an entirely new challenge; load is also variable and uncertain, and is strongly influenced by weather patterns. In this work we make a comparison between the day-ahead forecasting errors encountered in wind power forecasting and load forecasting. The study examines the distribution of errors from operational forecasting systems in two different Independent Systemmore » Operator (ISO) regions for both wind power and load forecasts at the day-ahead timeframe. The day-ahead timescale is critical in power system operations because it serves the unit commitment function for slow-starting conventional generators.« less

Competition explains limited attention and perceptual resources: implications for perceptual load and dilution theories.

PubMed

Scalf, Paige E; Torralbo, Ana; Tapia, Evelina; Beck, Diane M

2013-01-01

Both perceptual load theory and dilution theory purport to explain when and why task-irrelevant information, or so-called distractors are processed. Central to both explanations is the notion of limited resources, although the theories differ in the precise way in which those limitations affect distractor processing. We have recently proposed a neurally plausible explanation of limited resources in which neural competition among stimuli hinders their representation in the brain. This view of limited capacity can also explain distractor processing, whereby the competitive interactions and bias imposed to resolve the competition determine the extent to which a distractor is processed. This idea is compatible with aspects of both perceptual load and dilution models of distractor processing, but also serves to highlight their differences. Here we review the evidence in favor of a biased competition view of limited resources and relate these ideas to both classic perceptual load theory and dilution theory.

17 CFR 229.1107 - (Item 1107) Issuing entities.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false (Item 1107) Issuing entities....1107 (Item 1107) Issuing entities. Provide the following information about the issuing entity: (a) State the issuing entity's name and describe the issuing entity's form of organization, including the...

16 CFR 801.50 - Formation of unincorporated entities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Formation of unincorporated entities. 801.50... of unincorporated entities. (a) In the formation of an unincorporated entity (other than in... entity and the unincorporated entity itself may, in the formation transaction, be both acquiring and...

17 CFR 229.1107 - (Item 1107) Issuing entities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 1107) Issuing entities....1107 (Item 1107) Issuing entities. Provide the following information about the issuing entity: (a) State the issuing entity's name and describe the issuing entity's form of organization, including the...

16 CFR 801.50 - Formation of unincorporated entities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Formation of unincorporated entities. 801.50... of unincorporated entities. (a) In the formation of an unincorporated entity (other than in... entity and the unincorporated entity itself may, in the formation transaction, be both acquiring and...

How Academic Health Systems Can Achieve Population Health in Vulnerable Populations Through Value-Based Care: The Critical Importance of Establishing Trusted Agency.

PubMed

Wesson, Donald E; Kitzman, Heather E

2018-01-16

Improving population health may require health systems to proactively engage patient populations as partners in the implementation of healthy behaviors as a shared value using strategies that incentivize healthy outcomes for the population as a whole. The current reactive health care model, which focuses on restoring the health of individuals after it has been lost, will not achieve the goal of improved population health. To achieve this goal, health systems must proactively engage in partnerships with the populations they serve. Health systems will need the help of community entities and individuals who have the trust of the population being served to act on behalf of the health system if they are to achieve this effective working partnership. The need for these trusted agents is particularly pertinent for vulnerable and historically underserved segments of the population. In this Invited Commentary, the authors discuss ways by which health systems might identify, engage, and leverage trusted agents to improve the health of the population through value-based care.

The integration of emotional and symbolic components in multimodal communication

PubMed Central

Mehu, Marc

2015-01-01

Human multimodal communication can be said to serve two main purposes: information transfer and social influence. In this paper, I argue that different components of multimodal signals play different roles in the processes of information transfer and social influence. Although the symbolic components of communication (e.g., verbal and denotative signals) are well suited to transfer conceptual information, emotional components (e.g., non-verbal signals that are difficult to manipulate voluntarily) likely take a function that is closer to social influence. I suggest that emotion should be considered a property of communicative signals, rather than an entity that is transferred as content by non-verbal signals. In this view, the effect of emotional processes on communication serve to change the quality of social signals to make them more efficient at producing responses in perceivers, whereas symbolic components increase the signals’ efficiency at interacting with the cognitive processes dedicated to the assessment of relevance. The interaction between symbolic and emotional components will be discussed in relation to the need for perceivers to evaluate the reliability of multimodal signals. PMID:26217280

Building Comprehensive and Sustainable Health Informatics Institutions in Developing Countries: Moi University Experience.

PubMed

Were, Martin C; Siika, Abraham; Ayuo, Paul O; Atwoli, Lukoye; Esamai, Fabian

2015-01-01

Current approaches for capacity building in Health Informatics (HI) in developing countries mostly focus on training, and often rely on support from foreign entities. In this paper, we describe a comprehensive and multidimensional capacity-building framework by Lansang & Dennis, and its application for HI capacity building as implemented in a higher-education institution in Kenya. This framework incorporates training, learning-by-doing, partnerships, and centers of excellence. At Moi University (Kenya), the training dimensions include an accredited Masters in HI Program, PhD in HI, and HI short courses. Learning-by-doing occurs through work within MOH facilities at the AMPATH care and treatment program serving 3 million people. Moi University has formed strategic HI partnerships with Regenstrief Institute, Inc. (USA), University of Bergen (Norway), and Makerere University (Uganda), among others. The University has also created an Institute of Biomedical Informatics to serve as an HI Center of Excellence in the region. This Institute has divisions in Training, Research, Service and Administration. The HI capacity-building approach by Moi provides a model for adoption by other institutions in resource-limited settings.

Discovery of novel inhibitors disrupting HIF-1α/von Hippel–Lindau interaction through shape-based screening and cascade docking

PubMed Central

Xue, Xin; Zhao, Ning-Yi; Yu, Hai-Tao; Sun, Yuan; Kang, Chen; Huang, Qiong-Bin; Sun, Hao-Peng

2016-01-01

Major research efforts have been devoted to the discovery and development of new chemical entities that could inhibit the protein–protein interaction between HIF-1α and the von Hippel–Lindau protein (pVHL), which serves as the substrate recognition subunit of an E3 ligase and is regarded as a crucial drug target in cancer, chronic anemia, and ischemia. Currently there is only one class of compounds available to interdict the HIF-1α/pVHL interaction, urging the need to discover chemical inhibitors with more diversified structures. We report here a strategy combining shape-based virtual screening and cascade docking to identify new chemical scaffolds for the designing of novel inhibitors. Based on this strategy, nine active hits have been identified and the most active hit, 9 (ZINC13466751), showed comparable activity to pVHL with an IC50 of 2.0 ± 0.14 µM, showing the great potential of utilizing these compounds for further optimization and serving as drug candidates for the inhibition of HIF-1α/von Hippel–Lindau interaction. PMID:27994971

The role of an early-life variant of the oedipus complex in motivating religious endeavors.

PubMed

Osman, Marvin P

2004-01-01

A close reading of sources Freud used in writing Totem and Taboo supports the thesis that a predecessor archaic oedipus complex is instrumental in motivating religious worship. This early-life complex manifests a psychodynamic in which birth, growth, and self-realization, to varying degree in each individual, tend to be psychically correlated with diminution and harm vis-à-vis one's procreators. As a result, the psychodynamic is likely to induce unease over youth exercising its powers. The story of Adam and Eve, which depicts a growing self-determination being stymied and coming to grief, is a mythic epitome of this psychodynamic. Religious practices serve to expiate the sense of unease, partly by replenishing and even recasting seemingly diminished procreators, through myth and ritual, into omnipotent, immortal entities, and partly by reversing individuation's challenge to authority by exhorting submission to, and even union, with the divine parent. The sources used in demonstrating the various means whereby religious practices serve to ameliorate the burden of "original sin" include W. R. Smith (1894), the Old Testament, and studies of archaic religious rites, including those of the Aztecs.

Control of Fur synthesis by the non-coding RNA RyhB and iron-responsive decoding.

PubMed

Vecerek, Branislav; Moll, Isabella; Bläsi, Udo

2007-02-21

The Fe2+-dependent Fur protein serves as a negative regulator of iron uptake in bacteria. As only metallo-Fur acts as an autogeneous repressor, Fe2+scarcity would direct fur expression when continued supply is not obviously required. We show that in Escherichia coli post-transcriptional regulatory mechanisms ensure that Fur synthesis remains steady in iron limitation. Our studies revealed that fur translation is coupled to that of an upstream open reading frame (uof), translation of which is downregulated by the non-coding RNA (ncRNA) RyhB. As RyhB transcription is negatively controlled by metallo-Fur, iron depletion creates a negative feedback loop. RyhB-mediated regulation of uof-fur provides the first example for indirect translational regulation by a trans-encoded ncRNA. In addition, we present evidence for an iron-responsive decoding mechanism of the uof-fur entity. It could serve as a backup mechanism of the RyhB circuitry, and represents the first link between iron availability and synthesis of an iron-containing protein.

Effect of variable body mass on plantar foot pressure and off-loading device efficacy.

PubMed

Pirozzi, Kelly; McGuire, James; Meyr, Andrew J

2014-01-01

An increasing body of evidence has implicated obesity as having a negative effect on the development, treatment, and outcome of lower extremity pathologic entities, including diabetic foot disease. The objective of the present study was to increase the body of knowledge with respect to the effects of obesity on foot function. Specifically, we attempted to (1) describe the relationship between an increasing body mass index (BMI) on plantar foot pressures during gait, and (2) evaluate the efficacy of commonly prescribed off-loading devices with an increasing BMI. A repeated measures design was used to compare the peak plantar foot pressures under multiple test conditions, with the volunteers acting as their own controls. The primary outcome measure was the mean peak plantar pressure in the heel, midfoot, forefoot, and first metatarsal, and the 2 variables were modification of patient weight (from "normal" BMI to "overweight," "obese," and "morbidly obese") and footwear (from an athletic sneaker to a surgical shoe, controlled ankle motion walker, and total contact cast). Statistically significant increases in the peak plantar pressures were observed with increasing volunteer BMI weight class, regardless of the off-loading device used. The present investigation has provided unique and specific data with respect to the changes that occur in the peak plantar pressures with variable BMIs across different anatomic levels and with commonly used off-loading devices. From our results, we have concluded that although the plantar pressures increase with increasing weight, it appears that at least some reduction in pressure can be achieved with an off-loading device, most effectively with the total contact cast, regardless of the patient's BMI. Copyright © 2014 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.

46 CFR 111.30-15 - Nameplates.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Nameplates. 111.30-15 Section 111.30-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL... function. (b) Each nameplate for a circuit breaker must show the electrical load served and the setting of...

46 CFR 111.30-15 - Nameplates.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Nameplates. 111.30-15 Section 111.30-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL... function. (b) Each nameplate for a circuit breaker must show the electrical load served and the setting of...

46 CFR 111.30-15 - Nameplates.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Nameplates. 111.30-15 Section 111.30-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL... function. (b) Each nameplate for a circuit breaker must show the electrical load served and the setting of...

46 CFR 111.30-15 - Nameplates.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Nameplates. 111.30-15 Section 111.30-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL... function. (b) Each nameplate for a circuit breaker must show the electrical load served and the setting of...

46 CFR 111.30-15 - Nameplates.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Nameplates. 111.30-15 Section 111.30-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL... function. (b) Each nameplate for a circuit breaker must show the electrical load served and the setting of...

75 FR 8895 - Basin Electric Power Cooperative: Deer Creek Station

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-26

.... The purpose of the proposed Project is to help serve increased load demand for electric power in the... Basin Electric Power Cooperative: Deer Creek Station AGENCY: Rural Utilities Service, USDA. ACTION...) and the Western Area Power Administration (Western) have issued a Draft Environmental Impact Statement...

Midlife women, bone health, vegetables, herbs and fruit study. The Scarborough Fair study protocol.

PubMed

Gunn, Caroline A; Weber, Janet L; Kruger, Marlena C

2013-01-10

Bone loss is accelerated in middle aged women but increased fruit/vegetable intake positively affects bone health by provision of micronutrients essential for bone formation, buffer precursors which reduce acid load and phytochemicals affecting inflammation and oxidative stress. Animal studies demonstrated bone resorption inhibiting properties of specific vegetables, fruit and herbs a decade ago. To increase fruit/vegetable intake in post menopausal women to 9 servings/day using a food specific approach to significantly reduce dietary acid load and include specific vegetables, fruit and herbs with bone resorbing inhibiting properties to assess effect on bone turnover, metabolic and inflammatory markers. The Scarborough Fair Study is a randomised active comparator controlled multi centre trial. It aimed to increase fruit and vegetable intake in 100 post menopausal women from ≤ 5 servings/day to ≥ 9 servings/day for 3 months. The women in the dietary intervention were randomly assigned to one of the two arms of the study. Both groups consumed ≥ 9 servings/day of fruit/vegetables and selected herbs but the diet of each group emphasised different fruit/vegetables/herbs with one group (B) selecting from a range of vegetables, fruit and culinary herbs with bone resorbing inhibiting properties. 50 women formed a negative control group (Group C usual diet). Primary outcome variables were plasma bone markers assessed at baseline, 6 weeks and 12 weeks. Secondary outcome variables were plasma inflammation and metabolic markers and urinary electrolytes (calcium, magnesium, potassium and sodium) assessed at baseline and 12 weeks. Dietary intake and urine pH change also were outcome variables. The dietary change was calculated with 3 day diet diaries and a 24 hour recall. Intervention participants kept a twice weekly record of fruit, vegetable and herb intake and urine pH. This study will provide information on midlife women's bone health and how a dietary intervention increasing fruit and vegetable/herb intake affects bone, inflammatory and metabolic markers and urinary electrolyte excretion. It assesses changes in nutrient intake, estimated dietary acid load and sodium: potassium ratios. The study also explores whether specific fruit/vegetables and herbs with bone resorbing properties has an effect on bone markers. ACTRN 12611000763943.

Spatial release of cognitive load measured in a dual-task paradigm in normal-hearing and hearing-impaired listeners.

PubMed

Xia, Jing; Nooraei, Nazanin; Kalluri, Sridhar; Edwards, Brent

2015-04-01

This study investigated whether spatial separation between talkers helps reduce cognitive processing load, and how hearing impairment interacts with the cognitive load of individuals listening in multi-talker environments. A dual-task paradigm was used in which performance on a secondary task (visual tracking) served as a measure of the cognitive load imposed by a speech recognition task. Visual tracking performance was measured under four conditions in which the target and the interferers were distinguished by (1) gender and spatial location, (2) gender only, (3) spatial location only, and (4) neither gender nor spatial location. Results showed that when gender cues were available, a 15° spatial separation between talkers reduced the cognitive load of listening even though it did not provide further improvement in speech recognition (Experiment I). Compared to normal-hearing listeners, large individual variability in spatial release of cognitive load was observed among hearing-impaired listeners. Cognitive load was lower when talkers were spatially separated by 60° than when talkers were of different genders, even though speech recognition was comparable in these two conditions (Experiment II). These results suggest that a measure of cognitive load might provide valuable insight into the benefit of spatial cues in multi-talker environments.

Collaborative human-machine analysis to disambiguate entities in unstructured text and structured datasets

NASA Astrophysics Data System (ADS)

Davenport, Jack H.

2016-05-01

Intelligence analysts demand rapid information fusion capabilities to develop and maintain accurate situational awareness and understanding of dynamic enemy threats in asymmetric military operations. The ability to extract relationships between people, groups, and locations from a variety of text datasets is critical to proactive decision making. The derived network of entities must be automatically created and presented to analysts to assist in decision making. DECISIVE ANALYTICS Corporation (DAC) provides capabilities to automatically extract entities, relationships between entities, semantic concepts about entities, and network models of entities from text and multi-source datasets. DAC's Natural Language Processing (NLP) Entity Analytics model entities as complex systems of attributes and interrelationships which are extracted from unstructured text via NLP algorithms. The extracted entities are automatically disambiguated via machine learning algorithms, and resolution recommendations are presented to the analyst for validation; the analyst's expertise is leveraged in this hybrid human/computer collaborative model. Military capability is enhanced by these NLP Entity Analytics because analysts can now create/update an entity profile with intelligence automatically extracted from unstructured text, thereby fusing entity knowledge from structured and unstructured data sources. Operational and sustainment costs are reduced since analysts do not have to manually tag and resolve entities.

Surgery of the turbinates and “empty nose” syndrome

PubMed Central

Scheithauer, Marc Oliver

2011-01-01

Surgical therapy of the inferior and/or middle turbinate is indicated when conservative treatment options have failed. The desired goal is a reduction of the soft tissue volume of the turbinates regarding the individual anatomic findings, whilst simultaneously conserving as much mucosa as possible. As the turbinates serve as a functional entity within the nose, they ensure climatisation, humidification and cleaning of the inhaled air. Thus free nasal breathing means a decent quality of life, as well. Regarding the multitude of different surgical techniques, we confirm that no ideal standard technique for turbinate reduction has been developed so far. Moreover, there is a lack of prospective and comparable long-term studies, which makes it difficult to recommend evidence-based surgical techniques. However, the anterior turbinoplasty seems to fulfil the preconditions of limited tissue reduction and mucosa-preservation, and therefore it is the method of choice today. Radical resection of the turbinates may lead to severe functional disturbances developing a secondary atrophic rhinitis. The “empty nose” syndrome is a specific entity within the secondary atrophic rhinitis where intranasal changes in airflow result in disturbed climatisation and also interfere with pulmonary function. Results deriving from an actual in vivo study of climatisation and airflow in “empty nose” patients are presented. PMID:22073107

Anteroposterior chest radiograph vs. chest CT scan in early detection of pneumothorax in trauma patients.

PubMed

Omar, Hesham R; Mangar, Devanand; Khetarpal, Suneel; Shapiro, David H; Kolla, Jaya; Rashad, Rania; Helal, Engy; Camporesi, Enrico M

2011-09-27

Pneumothorax is a common complication following blunt chest wall trauma. In these patients, because of the restrictions regarding immobilization of the cervical spine, Anteroposterior (AP) chest radiograph is usually the most feasible initial study which is not as sensitive as the erect chest X-ray or CT chest for detection of a pneumothorax. We will present 3 case reports which serve for better understanding of the entity of occult pneumothorax. The first case is an example of a true occult pneumothorax where an initial AP chest X-ray revealed no evidence of pneumothorax and a CT chest immediately performed revealed evidence of pneumothorax. The second case represents an example of a missed rather than a truly occult pneumothorax where the initial chest radiograph revealed clues suggesting the presence of pneumothorax which were missed by the reading radiologist. The third case emphasizes the fact that "occult pneumothorax is predictable". The presence of subcutaneous emphesema and pulmonary contusion should call for further imaging with CT chest to rule out pneumothorax. Thoracic CT scan is therefore the "gold standard" for early detection of a pneumothorax in trauma patients. This report aims to sensitize readers to the entity of occult pneumothorax and create awareness among intensivists and ER physicians regarding the proper diagnosis and management.

Invited commentary: social capital, social contexts, and depression.

PubMed

Lindström, Martin

2008-05-15

The literature concerning social capital and health has grown exponentially during the past somewhat more than 10 years. The study by Kouvonen et al. (Am J Epidemiol 2008;167:1143-1151) is a longitudinal multilevel analysis of 33,577 public sector employees in Finland. The study shows a significant association between workplace social capital and depression, which is an interesting finding in a very new field of the study of social capital and health. However, the study also serves as an inspiration for further studies in important research areas. Workplace social capital may be investigated according to both horizontal, that is, social contacts and level of trust in relation to coworkers, and vertical, that is, relation with employer/supervisor across power gradients, dimensions. The fact that workplace social capital may affect social capital outside work and vice versa is also of interest. It is also important to define and identify the social context level in a correct way in multilevel studies. In the study by Kouvonen et al., the social context is not a geographic entity but an entity defined according to place of work, and the definition of such a social context entails several difficulties. This study presents interesting findings and provides a basis for future studies.

CampusGIS of the University of Cologne: a tool for orientation, navigation, and management

NASA Astrophysics Data System (ADS)

Baaser, U.; Gnyp, M. L.; Hennig, S.; Hoffmeister, D.; Köhn, N.; Laudien, R.; Bareth, G.

2006-10-01

The working group for GIS and Remote Sensing at the Department of Geography at the University of Cologne has established a WebGIS called CampusGIS of the University of Cologne. The overall task of the CampusGIS is the connection of several existing databases at the University of Cologne with spatial data. These existing databases comprise data about staff, buildings, rooms, lectures, and general infrastructure like bus stops etc. These information were yet not linked to their spatial relation. Therefore, a GIS-based method is developed to link all the different databases to spatial entities. Due to the philosophy of the CampusGIS, an online-GUI is programmed which enables users to search for staff, buildings, or institutions. The query results are linked to the GIS database which allows the visualization of the spatial location of the searched entity. This system was established in 2005 and is operational since early 2006. In this contribution, the focus is on further developments. First results of (i) including routing services in, (ii) programming GUIs for mobile devices for, and (iii) including infrastructure management tools in the CampusGIS are presented. Consequently, the CampusGIS is not only available for spatial information retrieval and orientation. It also serves for on-campus navigation and administrative management.

Inhibition of amyloid oligomerization into different supramolecular architectures by small molecules: mechanistic insights and design rules.

PubMed

Brahmachari, Sayanti; Paul, Ashim; Segal, Daniel; Gazit, Ehud

2017-05-01

Protein misfolding and aggregation have been associated with several human disorders, including Alzheimer's, Parkinson's and Huntington's diseases, as well as senile systemic amyloidosis and Type II diabetes. However, there is no current disease-modifying therapy available for the treatment of these disorders. In spite of extensive academic, pharmaceutical, medicinal and clinical research, a complete mechanistic model for this family of diseases is still lacking. In this review, we primarily discuss the different types of small molecular entities which have been used for the inhibition of the aggregation process of different amyloidogenic proteins under diseased conditions. These include small peptides, polyphenols, inositols, quinones and their derivatives, and metal chelator molecules. In recent years, these groups of molecules have been extensively studied using in vitro, in vivo and computational models to understand their mechanism of action and common structural features underlying the process of inhibition. A salient feature found to be instrumental in the process of inhibition is the balance between the aromatic unit that functions as the amyloid recognition unit and the hydrophilic amyloid breaker unit. The establishment of structure-function relationship for amyloid-modifying therapies by the various functional entities should serve as an important step toward the development of efficient therapeutics.

Sandboxes for Model-Based Inquiry

NASA Astrophysics Data System (ADS)

Brady, Corey; Holbert, Nathan; Soylu, Firat; Novak, Michael; Wilensky, Uri

2015-04-01

In this article, we introduce a class of constructionist learning environments that we call Emergent Systems Sandboxes ( ESSs), which have served as a centerpiece of our recent work in developing curriculum to support scalable model-based learning in classroom settings. ESSs are a carefully specified form of virtual construction environment that support students in creating, exploring, and sharing computational models of dynamic systems that exhibit emergent phenomena. They provide learners with "entity"-level construction primitives that reflect an underlying scientific model. These primitives can be directly "painted" into a sandbox space, where they can then be combined, arranged, and manipulated to construct complex systems and explore the emergent properties of those systems. We argue that ESSs offer a means of addressing some of the key barriers to adopting rich, constructionist model-based inquiry approaches in science classrooms at scale. Situating the ESS in a large-scale science modeling curriculum we are implementing across the USA, we describe how the unique "entity-level" primitive design of an ESS facilitates knowledge system refinement at both an individual and social level, we describe how it supports flexible modeling practices by providing both continuous and discrete modes of executability, and we illustrate how it offers students a variety of opportunities for validating their qualitative understandings of emergent systems as they develop.

Influence network linkages across implementation strategy conditions in a randomized controlled trial of two strategies for scaling up evidence-based practices in public youth-serving systems.

PubMed

Palinkas, Lawrence A; Holloway, Ian W; Rice, Eric; Brown, C Hendricks; Valente, Thomas W; Chamberlain, Patricia

2013-11-14

Given the importance of influence networks in the implementation of evidence-based practices and interventions, it is unclear whether such networks continue to operate as sources of information and advice when they are segmented and disrupted by randomization to different implementation strategy conditions. The present study examines the linkages across implementation strategy conditions of social influence networks of leaders of youth-serving systems in 12 California counties participating in a randomized controlled trial of community development teams (CDTs) to scale up use of an evidence-based practice. Semi-structured interviews were conducted with 38 directors, assistant directors, and program managers of county probation, mental health, and child welfare departments. A web-based survey collected additional quantitative data on information and advice networks of study participants. A mixed-methods approach to data analysis was used to create a sociometric data set (n = 176) to examine linkages between treatment and standard conditions. Of those network members who were affiliated with a county (n = 137), only 6 (4.4%) were directly connected to a member of the opposite implementation strategy condition; 19 (13.9%) were connected by two steps or fewer to a member of the opposite implementation strategy condition; 64 (46.7%) were connected by three or fewer steps to a member of the opposite implementation strategy condition. Most of the indirect steps between individuals who were in different implementation strategy conditions were connections involving a third non-county organizational entity that had an important role in the trial in keeping the implementation strategy conditions separate. When these entities were excluded, the CDT network exhibited fewer components and significantly higher betweenness centralization than did the standard condition network. Although the integrity of the RCT in this instance was not compromised by study participant influence networks, RCT designs should consider how influence networks may extend beyond boundaries established by the randomization process in implementation studies. NCT00880126.

42 CFR 417.484 - Requirement applicable to related entities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 3 2011-10-01 2011-10-01 false Requirement applicable to related entities. 417.484... entities. (a) Definition. As used in this section, related entity means any entity that is related to the... agrees to require all related entities to agree that— (1) HHS, the Comptroller General, or their...

26 CFR 301.7701-5 - Domestic and foreign business entities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Domestic and foreign business entities. 301... foreign business entities. (a) Domestic and foreign business entities. A business entity (including an entity that is disregarded as separate from its owner under § 301.7701-2(c)) is domestic if it is created...

22 CFR 96.8 - Fees charged by accrediting entities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Fees charged by accrediting entities. 96.8... Duties of Accrediting Entities § 96.8 Fees charged by accrediting entities. (a) An accrediting entity may... fees approved by the Secretary. Before approving a schedule of fees proposed by an accrediting entity...

26 CFR 301.7701-5 - Domestic and foreign business entities.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 18 2011-04-01 2011-04-01 false Domestic and foreign business entities. 301... foreign business entities. (a) Domestic and foreign business entities. A business entity (including an entity that is disregarded as separate from its owner under § 301.7701-2(c)) is domestic if it is created...

42 CFR 417.484 - Requirement applicable to related entities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Requirement applicable to related entities. 417.484... entities. (a) Definition. As used in this section, related entity means any entity that is related to the... agrees to require all related entities to agree that— (1) HHS, the Comptroller General, or their...

42 CFR 455.104 - Disclosure by Medicaid providers and fiscal agents: Information on ownership and control.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., fiscal agents, and managed care entities provide the following disclosures: (1)(i) The name and address... entity, fiscal agent, or managed care entity. The address for corporate entities must include as... disclosing entity as a spouse, parent, child, or sibling. (3) The name of any other disclosing entity (or...

Yi-Hsiang Yu | NREL

Science.gov Websites

Yi-Hsiang Yu's expertise is in marine energy system design and performance analysis, hydrodynamics , a wave-to-wire numerical model for design and analysis of wave energy conversion systems, wave tank the design load for wave energy systems. Yi-Hsiang is currently serving as the associate editor of the

Cyber Infrastructure: The Forgotten Vulnerability

DTIC Science & Technology

2014-05-22

would like to thank my wife and children for their love and support. They truly bear the brunt of the load and they allow me to continue to serve...forms of entrepreneurship , advances in technology, the spread of free speech, and social networks that energize the economy.112 In February 2013

USE OF PBPK MODELING TO ASSESS CYPERMETHRIN EXPOSURE IN YOUNG AFTER A RESIDENTIAL APPLICATION

EPA Science Inventory

PBPK modeling was used to interpret exposure to cypermethrin among children in a small community of Jacksonville,FL. Sock loadings of cypermethin were used as a measure of exposure to cypermethrin. Urinary markers served as a measure of absorbed dose. In a comparison of presum...

Low-energy gamma ray inspection of brazed aluminum joints

NASA Technical Reports Server (NTRS)

Brown, J. A.

1967-01-01

Americium 241 serves as a suitable radioisotope /gamma ray source/ and exposure probe for radiographic inspection of brazed aluminum joints in areas of limited accessibility. The powdered isotope is contained in a sealed capsule mounted at the end of a spring-loaded pushrod in the probe assembly.

Serving through Disaster

ERIC Educational Resources Information Center

Kuzyk, Raya

2007-01-01

Disaster planning focuses on future function and recovery, on helping libraries expeditiously return to their original states of operation. It all but ignores the concept of continuous function throughout a disaster. This is not true in the private and government sectors, however, which have managed to cover a wider load of disaster response…

76 FR 66229 - Transmission Planning Reliability Standards

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-26

... Transmission Services, at all demand levels over the range of forecast system demands, under the contingency... any planned firm load that is not directly served by the elements that are removed from service as a... to plan for the loss of firm service for a single contingency, the Commission finds that their...

Virtualized MME Design for IoT Support in 5G Systems.

PubMed

Andres-Maldonado, Pilar; Ameigeiras, Pablo; Prados-Garzon, Jonathan; Ramos-Munoz, Juan Jose; Lopez-Soler, Juan Manuel

2016-08-22

Cellular systems are recently being considered an option to provide support to the Internet of Things (IoT). To enable this support, the 3rd Generation Partnership Project (3GPP) has introduced new procedures specifically targeted for cellular IoT. With one of these procedures, the transmissions of small and infrequent data packets from/to the devices are encapsulated in signaling messages and sent through the control plane. However, these transmissions from/to a massive number of devices may imply a major increase of the processing load on the control plane entities of the network and in particular on the Mobility Management Entity (MME). In this paper, we propose two designs of an MME based on Network Function Virtualization (NFV) that aim at facilitating the IoT support. The first proposed design partially separates the processing resources dedicated to each traffic class. The second design includes traffic shaping to control the traffic of each class. We consider three classes: Mobile Broadband (MBB), low latency Machine to Machine communications (lM2M) and delay-tolerant M2M communications. Our proposals enable reducing the processing resources and, therefore, the cost. Additionally, results show that the proposed designs lessen the impact between classes, so they ease the compliance of the delay requirements of MBB and lM2M communications.

Representation and Management of the Knowledge of Brittle Deformation in Shear Zones Using Microstructural Data From the SAFOD Core Samples

NASA Astrophysics Data System (ADS)

Babaie, H. A.; Broda, C. M.; Kumar, A.; Hadizadeh, J.

2010-12-01

Web access to data that represent knowledge acquired by investigators studying the microstructures in the core samples of the SAFOD (San Andreas Observatory at Depth) project can help scientists efficiently integrate and share knowledge, query the data, and update the knowledge base on the Web. To achieve this, we have used OWL (Web Ontology Language) to build the brittle deformation ontology for the microstructures observed in the SAFOD core samples, by explicitly formalizing the knowledge about deformational processes, geological objects undergoing deformation, and the underlying mechanical and environmental conditions in brittle shear zones. The developed Web-based ‘SAFOD Brittle Microstructure and Mechanics Knowledge base’ (SAFOD BM2KB), which instantiates this ontology and is available at http://codd.cs.gsu.edu:9999/safod/index.jsp, will host and serve data that pertains to spatial objects, such as microstructure, gouge, fault, and SEM image, acquired by the SAFOD investigators through the studies of the SAFOD core samples. Deformation in shear zones involves complex brittle and ductile processes that alter, create, and/or destroy a wide variety of one- to three-dimensional, multi-scale spatial entities such as rocks and their constituent minerals and structure. These processes occur through a series of sub-processes that happen in different time intervals, and affect the spatial objects at granular to regional scales within shear zones. The processes bring about qualitative change to the spatial entities over time intervals that start and end with events. Processes, such as mylonitization and cataclastic flow, change the spatial location, distribution, dimension, size, shape, and orientation of some objects through translation, rotation and strain. These processes may also result in newly formed entities, such as a new mineral, gouge, vein, or fault, during one or more phases of deformation. Deformation processes may also destroy entities, such as a mineral, fossil, or original structure. Laboratory investigations by the SAFOD scientists result in ever-increasing volumes of complex data related to different tectonic processes, deformed rocks, and structures. These data are often published in the tables of scientific articles or are stored in personal Excel worksheets or, in rare cases, in a network community database. It is extremely hard to integrate autonomously built databases distributed on the Web because of their heterogeneous schemas. As a closed world model, databases can only store and serve a finite set of static data that are known to be true. They cannot represent knowledge in a constantly changing, open world. In contrast, integration of scientific data and presentation of their underlying knowledge can be achieved through the use of Semantic Web technologies. These technologies are capable of handling an infinite supply of known and yet to be known facts due to their open world model. The inference rules of OWL and its underlying RDFS and RDF semantic languages allow formal and explicit specification of the theories and knowledge of a particular domain such as brittle deformation in shear zone.

Zirconia-implant-supported all-ceramic crowns withstand long-term load: a pilot investigation.

PubMed

Kohal, Ralf-J; Klaus, Gerold; Strub, Jörg R

2006-10-01

The purpose of this pilot investigation was to test whether zirconia implants restored with different all-ceramic crowns would fulfill the biomechanical requirements for clinical use. Therefore, all-ceramic Empress-1 and Procera crowns were cemented on zirconia implants and exposed to the artificial mouth. Afterwards, the fracture strength of the all-ceramic implant-crown systems was evaluated. Conventional titanium implants restored with porcelain-fused-to-metal (PFM) crowns served as controls. Sixteen titanium implants with 16 PFM crowns and 32 zirconia implants with 16 Empress-1 crowns and 16 Procera crowns each--i.e., three implant-crown groups--were used in this investigation. The titanium implants were fabricated using the ReImplant system and the zirconia implants using the Celay system. The upper left central incisor served as a model for the fabrication of the implants and the crowns. Eight samples of each group were submitted to a long-term load test in the artificial mouth (1.2 million chewing cycles). Subsequently, a fracture strength test was performed with seven of the eight crowns. The remaining eight samples of each group were not submitted to the long-term load in the artificial mouth but were fracture-tested immediately. One loaded and one unloaded sample of each group were evaluated regarding the marginal fit of the crowns. All test samples survived the exposure to the artificial mouth. Three Empress-1 crowns showed cracks in the area of the loading steatite ball. The values for the fracture load in the titanium implant-PFM crown group without artificial loading ranged between 420 and 610 N (mean: 531.4 N), between 460 and 570 N (mean: 512.9 N) in the Empress-1 crown group, and in the Procera crown group the values were between 475 and 700 N (mean: 575.7 N) when not loaded artificially. The results when the specimens were loaded artificially with 1.2 million cycles were as follows: the titanium implant-PFM crowns fractured between 440 and 950 N (mean: 668.6 N), the Empress-1 crowns between 290 and 550 N (mean: 410.7 N), and the Procera crowns between 450 and 725 N (mean: 555.5 N). No statistically significant differences could be found among the groups without artificial load. The fracture values for the PFM and the Procera crowns after artificial loading were statistically significantly higher than that for the loaded Empress-1 crowns. There was no significant difference between the PFM crown group and the Procera group. Within the limits of this pilot investigation, it seems that zirconia implants restored with the Procera crowns possibly fulfill the biomechanical requirements for anterior teeth. However, further investigations with larger sample sizes have to confirm these preliminary results. As three Empress-1 crowns showed crack development in the loading area of the steatite balls in the artificial mouth, their clinical use on zirconia implants has to be questioned.

Design and power management of an offshore medium voltage DC microgrid realized through high voltage power electronics technologies and control

NASA Astrophysics Data System (ADS)

Grainger, Brandon Michael

The growth in the electric power industry's portfolio of Direct Current (DC) based generation and loads have captured the attention of many leading research institutions. Opportunities for using DC based systems have been explored in electric ship design and have been a proven, reliable solution for transmitting bulk power onshore and offshore. To integrate many of the renewable resources into our existing AC grid, a number of power conversions through power electronics are required to condition the equipment for direct connection. Within the power conversion stages, there is always a requirement to convert to or from DC. The AC microgrid is a conceptual solution proposed for integrating various types of renewable generation resources. The fundamental microgrid requirements include the capability of operating in islanding mode and/or grid connected modes. The technical challenges associated with microgrids include (1) operation modes and transitions that comply with IEEE1547 without extensive custom engineering and (2) control architecture and communication. The Medium Voltage DC (MVDC) architecture, explored by the University of Pittsburgh, can be visualized as a special type of DC microgrid. This dissertation is multi-faceted, focused on many design aspects of an offshore DC microgrid. The focal points of the discussion are focused on optimized high power, high frequency magnetic material performance in electric machines, transformers, and DC/DC power converters---all components found within offshore, power system architectures. A new controller design based upon model reference control is proposed and shown to stabilize the electric motor drives (modeled as constant power loads), which serve as the largest power consuming entities in the microgrid. The design and simulation of a state-of-the-art multilevel converter for High Voltage DC (HVDC) is discussed and a component sensitivity analysis on fault current peaks is explored. A power management routine is proposed and evaluated as the DC microgrid is disturbed through various mode transitions. Finally, two communication protocols are described for the microgrid---one to minimize communication overhead inside the microgrid and another to provide robust and scalable intra-grid communication. The work presented is supported by Asea Brown Boveri (ABB) Corporate Research Center within the Active Grid Infrastructure program, the Advanced Research Project Agency - Energy (ARPA-E) through the Solar ADEPT program, and Mitsubishi Electric Corporation (MELCO).

Flying Lessons: Learning from Ryanair's Cost Reduction Culture

NASA Technical Reports Server (NTRS)

Lawton, Thomas C.

2000-01-01

Through radically improving the value equation for airline customers, Ryanair has served to shake-up established norms and practices in European aviation. Underpinning its price leadership and market success is a vigorous and relentless cost reduction ethos and resultant low break-even load factor. Ryanair has lowered European airline cost structures considerably, shattering existing cost floors. Few competitors are able to follow, either because they do not know how or they are unable due to social settlement obligations or service commitments. At the same time, the company has maintained high average load factors on its flights. Taken in conjunction with its low break-even load factor, this results in consistently high overall profit margins. On this basis, Ryanair is likely to remain a significant competitor and increase its market presence and success across Europe.

Tuning the Catalytic Activity of Subcellular Nanoreactors.

PubMed

Jakobson, Christopher M; Chen, Yiqun; Slininger, Marilyn F; Valdivia, Elias; Kim, Edward Y; Tullman-Ercek, Danielle

2016-07-31

Bacterial microcompartments are naturally occurring subcellular organelles of bacteria and serve as a promising scaffold for the organization of heterologous biosynthetic pathways. A critical element in the design of custom biosynthetic organelles is quantitative control over the loading of heterologous enzymes to the interior of the organelles. We demonstrate that the loading of heterologous proteins to the 1,2-propanediol utilization microcompartment of Salmonella enterica can be controlled using two strategies: by modulating the transcriptional activation of the microcompartment container and by coordinating the expression of the microcompartment container and the heterologous cargo. These strategies allow general control over the loading of heterologous proteins localized by two different N-terminal targeting peptides and represent an important step toward tuning the catalytic activity of bacterial microcompartments for increased biosynthetic productivity. Copyright © 2016. Published by Elsevier Ltd.

Building application of solar energy. Study no. 4: Scenarios for the utilization of solar energy in southern California buildings, change 1

NASA Technical Reports Server (NTRS)

Davis, E. S.; French, R. L.; Hirshberg, A. S.

1976-01-01

Plausible future market scenarios for solar heating and cooling systems into buildings in the area served by the Southern California Edison Company. A range of plausible estimates for the number of solar systems which might be installed and the electrical energy which might be displaced by energy from these systems are provided. The effect on peak electrical load was not explicitly calculated but preliminary conclusions concerning peak load can be inferred from the estimates presented. Two markets are investigated: the single family market and the large power commercial market.

Simultaneous optimization of the cavity heat load and trip rates in linacs using a genetic algorithm

DOE PAGES

Terzić, Balša; Hofler, Alicia S.; Reeves, Cody J.; ...

2014-10-15

In this paper, a genetic algorithm-based optimization is used to simultaneously minimize two competing objectives guiding the operation of the Jefferson Lab's Continuous Electron Beam Accelerator Facility linacs: cavity heat load and radio frequency cavity trip rates. The results represent a significant improvement to the standard linac energy management tool and thereby could lead to a more efficient Continuous Electron Beam Accelerator Facility configuration. This study also serves as a proof of principle of how a genetic algorithm can be used for optimizing other linac-based machines.

AUTOMATED UTILITY SERVICE AREA ASSESSMENT UNDER EMERGENCY CONDITIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

G. TOOLE; S. LINGER

2001-01-01

All electric utilities serve power to their customers through a variety of functional levels, notably substations. The majority of these components consist of distribution substations operating at lower voltages while a small fraction are transmission substations. There is an associated geographical area that encompasses customers who are served, defined as the service area. Analysis of substation service areas is greatly complicated by several factors: distribution networks are often highly interconnected which allows a multitude of possible switching operations; also, utilities dynamically alter the network topology in order to respond to emergency events. As a result, the service area for amore » substation can change radically. A utility will generally attempt to minimize the number of customers outaged by switching effected loads to alternate substations. In this manner, all or a portion of a disabled substation's load may be served by one or more adjacent substations. This paper describes a suite of analytical tools developed at Los Alamos National Laboratory (LANL), which address the problem of determining how a utility might respond to such emergency events. The estimated outage areas derived using the tools are overlaid onto other geographical and electrical layers in a geographic information system (GIS) software application. The effects of a power outage on a population, other infrastructures, or other physical features, can be inferred by the proximity of these features to the estimated outage area.« less

Conversation Intention Perception based on Knowledge Base

DTIC Science & Technology

2014-05-01

Yi Liu Gastritis Fracture Vomit Pain Bleeding thirst Anti-acid Clarithromycin styptic Aspirin Symptom Medicine Disease 1/117 1/157 1/20...occurrence frequency. Firstly, we compute the distance between two entities. For example, distance between entity Gastritis and entity Vomit is...considered as one as they are connected directly, distance between entity Gastritis and entity Fracture is two since they are con- nected through entity

7 CFR 1738.16 - Eligible entities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Eligible entities. 1738.16 Section 1738.16... Eligible entities. (a) RUS makes broadband loans to legally organized entities providing, or proposing to provide, broadband services in eligible rural communities. (1) Types of eligible entities include...

7 CFR 1738.16 - Eligible entities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 11 2011-01-01 2011-01-01 false Eligible entities. 1738.16 Section 1738.16... Eligible entities. (a) RUS makes broadband loans to legally organized entities providing, or proposing to provide, broadband services in eligible rural communities. (1) Types of eligible entities include...

7 CFR 63.4 - Eligible entity.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 3 2011-01-01 2011-01-01 false Eligible entity. 63.4 Section 63.4 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... IMPROVEMENT CENTER General Provisions Definitions § 63.4 Eligible entity. Eligible entity means an entity that...

Thyme to touch: Infants possess strategies that protect them from dangers posed by plants

PubMed Central

Wertz, Annie E.; Wynn, Karen

2013-01-01

Plants have been central to human life as sources of food and raw materials for artifact construction over evolutionary time. But plants also have chemical and physical defenses (such as harmful toxins and thorns) that provide protection from herbivores. The presence of these defenses has shaped the behavioral strategies of non-human animals. Here we report evidence that human infants possess strategies that would serve to protect them from dangers posed by plants. Across two experiments, infants as young as eight months exhibit greater reluctance to manually explore plants compared to other entities. These results expand the growing literature showing that infants are sensitive to certain ancestrally recurrent dangers, and provide a basis for further exploration. PMID:24161794

Veterans worry that unexplained medical problems a legacy of service during Gulf War.

PubMed Central

Robinson, A

1995-01-01

Some Canadians who served in the military in the Persian Gulf 4 years ago complain of a range of symptoms commonly described as Gulf War syndrome. Although the syndrome is not recognized as a clinical entity, symptoms include fatigue, lack of sleep, depression, cognitive problems, rashes, bone aches, lassitude, lack of motivation, forgetfulness, mood changes irritability and diarrhea. The medical branch of the Department of National Defence has established programs to inform, guide diagnosis and reach out to symptomatic veterans of the Persian Gulf conflict. Civilian physicians who provide similar care to military personnel who participated in the conflict are invited to call the medical branch (613 996-3752) for further information. Images p945-a PMID:7697587

Buckling Response of a Large-Scale, Seamless, Orthogrid-Stiffened Metallic Cylinder

NASA Technical Reports Server (NTRS)

Rudd, Michelle Tillotson; Hilburger, Mark W.; Lovejoy, Andrew E.; Lindell, Michael C.; Gardner, Nathaniel W.; Schultz, Marc R.

2018-01-01

Results from the buckling test of a compression-loaded 8-ft-diameter seamless (i.e., without manufacturing joints), orthogrid-stiffened metallic cylinder are presented. This test was used to assess the buckling response and imperfection sensitivity characteristics of a seamless cylinder. In addition, the test article and test served as a technology demonstration to show the application of the flow forming manufacturing process to build more efficient buckling-critical structures by eliminating the welded joints that are traditionally used in the manufacturing of large metallic barrels. Pretest predictions of the cylinder buckling response were obtained using a finite-element model that included measured geometric imperfections. The buckling load predicted using this model was 697,000 lb, and the test article buckled at 743,000 lb (6% higher). After the test, the model was revised to account for measured variations in skin and stiffener geometry, nonuniform loading, and material properties. The revised model predicted a buckling load of 754,000 lb, which is within 1.5% of the tested buckling load. In addition, it was determined that the load carrying capability of the seamless cylinder is approximately 28% greater than a corresponding cylinder with welded joints.

A gravity loading countermeasure skinsuit

NASA Astrophysics Data System (ADS)

Waldie, James M.; Newman, Dava J.

2011-04-01

Despite the use of several countermeasures, significant physiological deconditioning still occurs during long duration spaceflight. Bone loss - primarily due to the absence of loading in microgravity - is perhaps the greatest challenge to resolve. This paper describes a conceptual Gravity Loading Countermeasure Skinsuit (GLCS) that induces loading on the body to mimic standing and - when integrated with other countermeasures - exercising on Earth. Comfort, mobility and other operational issues were explored during a pilot study carried out in parabolic flight for prototype suits worn by three subjects. Compared to the 1- or 2-stage Russian Pingvin Suits, the elastic mesh of the GLCS can create a loading regime that gradually increases in hundreds of stages from the shoulders to the feet, thereby reproducing the weight-bearing regime normally imparted by gravity with much higher resolution. Modelling shows that the skinsuit requires less than 10 mmHg (1.3 kPa) of compression for three subjects of varied gender, height and mass. Negligible mobility restriction and excellent comfort properties were found during the parabolic flights, which suggests that crewmembers should be able to work normally, exercise or sleep while wearing the suit. The suit may also serve as a practical 1 g harness for exercise countermeasures and vibration applications to improve dynamic loading.

Moderate tibia axial loading promotes discordant response of bone composition parameters and mechanical properties in a hindlimb unloading rat model.

PubMed

Yang, Peng-Fei; Huang, Ling-Wei; Nie, Xiao-Tong; Yang, Yue; Wang, Zhe; Ren, Li; Xu, Hui-Yun; Shang, Peng

2018-06-01

The purpose of the present study was to characterize the dynamic alterations of bone composition parameters and mechanical properties to disuse and mechanical intervention. A tail suspension hindlimb unloading model and an in vivo axial tibia loading model in rats were used. A moderate mechanical loading that was capable of engendering 800 µε tibia strain was applied to the right tibia of rats in both control and hindlimb unloading group across 28 days of the experimental period. The contralateral tibia served as control. Hindlimb unloading led to bone loss in tibia from day 14. Bone mineral density, mineral content and mechanical properties responded differently with microstructure to disuse in timing course. Mechanical loading of 800 µε tibia strain failed to alter the bone of the control group, but minimized the detrimental effects of unloading by completely prohibiting the decrease of bone mineral content and main mechanical properties after 28 days. Less obvious influence of mechanical loading on bone microstructure was found. The moderate mechanical loading is not able to stimulate the mechanical response of healthy tibia, but indeed lead to discordant recovery of bone composition parameters and mechanical properties.

Influence of Solvent on the Drug-Loading Process of Amphiphilic Nanogel Star Polymers.

PubMed

Carr, Amber C; Piunova, Victoria A; Maarof, Hasmerya; Rice, Julia E; Swope, William C

2018-05-31

We present an all-atom molecular dynamics study of the effect of a range of organic solvents (dichloromethane, diethyl ether, toluene, methanol, dimethyl sulfoxide, and tetrahydrofuran) on the conformations of a nanogel star polymeric nanoparticle with solvophobic and solvophilic structural elements. These nanoparticles are of particular interest for drug delivery applications. As drug loading generally takes place in an organic solvent, this work serves to provide insight into the factors controlling the early steps of that process. Our work suggests that nanoparticle conformational structure is highly sensitive to the choice of solvent, providing avenues for further study as well as predictions for both computational and experimental explorations of the drug-loading process. Our findings suggest that when used in the drug-loading process, dichloromethane, tetrahydrofuran, and toluene allow for a more extensive and increased drug-loading into the interior of nanogel star polymers of the composition studied here. In contrast, methanol is more likely to support shallow or surface loading and, consequently, faster drug release rates. Finally, diethyl ether should not work in a formulation process since none of the regions of the nanogel star polymer appear to be sufficiently solvated by it.

Chemical Entity Recognition and Resolution to ChEBI

PubMed Central

Grego, Tiago; Pesquita, Catia; Bastos, Hugo P.; Couto, Francisco M.

2012-01-01

Chemical entities are ubiquitous through the biomedical literature and the development of text-mining systems that can efficiently identify those entities are required. Due to the lack of available corpora and data resources, the community has focused its efforts in the development of gene and protein named entity recognition systems, but with the release of ChEBI and the availability of an annotated corpus, this task can be addressed. We developed a machine-learning-based method for chemical entity recognition and a lexical-similarity-based method for chemical entity resolution and compared them with Whatizit, a popular-dictionary-based method. Our methods outperformed the dictionary-based method in all tasks, yielding an improvement in F-measure of 20% for the entity recognition task, 2–5% for the entity-resolution task, and 15% for combined entity recognition and resolution tasks. PMID:25937941

47 CFR 90.1103 - Designated entities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Designated entities. 90.1103 Section 90.1103... Designated entities. (a) This section addresses certain issues concerning designated entities in the Location... provisions. (1) A small business is an entity that, together with its affiliates and controlling interests...

47 CFR 90.1103 - Designated entities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false Designated entities. 90.1103 Section 90.1103... Designated entities. (a) This section addresses certain issues concerning designated entities in the Location... provisions. (1) A small business is an entity that, together with its affiliates and controlling interests...

31 CFR 596.308 - Person; entity.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Person; entity. 596.308 Section 596... General Definitions § 596.308 Person; entity. (a) The term person means an individual or entity. (b) The term entity means a partnership, association, corporation, or other organization. ...

31 CFR 596.308 - Person; entity.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Person; entity. 596.308 Section 596... General Definitions § 596.308 Person; entity. (a) The term person means an individual or entity. (b) The term entity means a partnership, association, corporation, or other organization. ...

78 FR 22270 - Special Fraud Alert: Physician-Owned Entities

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-15

...] Special Fraud Alert: Physician-Owned Entities AGENCY: Office of Inspector General (OIG), HHS. ACTION... Physician-Owned Entities. Specifically, the Special Fraud Alert addressed physician-owned entities that... publication of the Special Fraud Alert on Physician-Owned Entities, an inadvertent error appeared in the DATES...

Interactive entity resolution in relational data: a visual analytic tool and its evaluation.

PubMed

Kang, Hyunmo; Getoor, Lise; Shneiderman, Ben; Bilgic, Mustafa; Licamele, Louis

2008-01-01

Databases often contain uncertain and imprecise references to real-world entities. Entity resolution, the process of reconciling multiple references to underlying real-world entities, is an important data cleaning process required before accurate visualization or analysis of the data is possible. In many cases, in addition to noisy data describing entities, there is data describing the relationships among the entities. This relational data is important during the entity resolution process; it is useful both for the algorithms which determine likely database references to be resolved and for visual analytic tools which support the entity resolution process. In this paper, we introduce a novel user interface, D-Dupe, for interactive entity resolution in relational data. D-Dupe effectively combines relational entity resolution algorithms with a novel network visualization that enables users to make use of an entity's relational context for making resolution decisions. Since resolution decisions often are interdependent, D-Dupe facilitates understanding this complex process through animations which highlight combined inferences and a history mechanism which allows users to inspect chains of resolution decisions. An empirical study with 12 users confirmed the benefits of the relational context visualization on the performance of entity resolution tasks in relational data in terms of time as well as users' confidence and satisfaction.

A generalized threshold model for computing bed load grain size distribution

NASA Astrophysics Data System (ADS)

Recking, Alain

2016-12-01

For morphodynamic studies, it is important to compute not only the transported volumes of bed load, but also the size of the transported material. A few bed load equations compute fractional transport (i.e., both the volume and grain size distribution), but many equations compute only the bulk transport (a volume) with no consideration of the transported grain sizes. To fill this gap, a method is proposed to compute the bed load grain size distribution separately to the bed load flux. The method is called the Generalized Threshold Model (GTM), because it extends the flow competence method for threshold of motion of the largest transported grain size to the full bed surface grain size distribution. This was achieved by replacing dimensional diameters with their size indices in the standard hiding function, which offers a useful framework for computation, carried out for each indices considered in the range [1, 100]. New functions are also proposed to account for partial transport. The method is very simple to implement and is sufficiently flexible to be tested in many environments. In addition to being a good complement to standard bulk bed load equations, it could also serve as a framework to assist in analyzing the physics of bed load transport in future research.

Modeling and Depletion Simulations for a High Flux Isotope Reactor Cycle with a Representative Experiment Loading

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chandler, David; Betzler, Ben; Hirtz, Gregory John

2016-09-01

The purpose of this report is to document a high-fidelity VESTA/MCNP High Flux Isotope Reactor (HFIR) core model that features a new, representative experiment loading. This model, which represents the current, high-enriched uranium fuel core, will serve as a reference for low-enriched uranium conversion studies, safety-basis calculations, and other research activities. A new experiment loading model was developed to better represent current, typical experiment loadings, in comparison to the experiment loading included in the model for Cycle 400 (operated in 2004). The new experiment loading model for the flux trap target region includes full length 252Cf production targets, 75Se productionmore » capsules, 63Ni production capsules, a 188W production capsule, and various materials irradiation targets. Fully loaded 238Pu production targets are modeled in eleven vertical experiment facilities located in the beryllium reflector. Other changes compared to the Cycle 400 model are the high-fidelity modeling of the fuel element side plates and the material composition of the control elements. Results obtained from the depletion simulations with the new model are presented, with a focus on time-dependent isotopic composition of irradiated fuel and single cycle isotope production metrics.« less

DNS load balancing in the CERN cloud

NASA Astrophysics Data System (ADS)

Reguero Naredo, Ignacio; Lobato Pardavila, Lorena

2017-10-01

Load Balancing is one of the technologies enabling deployment of large-scale applications on cloud resources. A DNS Load Balancer Daemon (LBD) has been developed at CERN as a cost-effective way to balance applications accepting DNS timing dynamics and not requiring persistence. It currently serves over 450 load-balanced aliases with two small VMs acting as master and slave. The aliases are mapped to DNS subdomains. These subdomains are managed with DDNS according to a load metric, which is collected from the alias member nodes with SNMP. During the last years, several improvements were brought to the software, for instance: support for IPv6, parallelization of the status requests, implementing the client in Python to allow for multiple aliases with differentiated states on the same machine or support for application state. The configuration of the Load Balancer is currently managed by a Puppet type. It discovers the alias member nodes and gets the alias definitions from the Ermis REST service. The Aiermis self-service GUI for the management of the LB aliases has been produced and is based on the Ermis service above that implements a form of Load Balancing as a Service (LBaaS). The Ermis REST API has authorisation based in Foreman hostgroups. The CERN DNS LBD is Open Software with Apache 2 license.

An alternative choice of lidocaine-loaded liposomes: lidocaine-loaded lipid-polymer hybrid nanoparticles for local anesthetic therapy.

PubMed

Wang, Jianguo; Zhang, Laizhu; Chi, Huimin; Wang, Shilei

2016-05-01

The skin permeation enhancement of local anesthetics by newer innovative nanotechnologies has been an appealing field recently. However, which nanocarrier is better for drug loading and has better stability? Therefore, the aim of our study was to compare two kinds of nanocarriers: liposomes and lipid-polymer hybrid nanoparticles (LPNs) for lidocaine (LA) delivery. LA-loaded liposomes (LA-LPs) and LPNs (LA-LPNs) were prepared. Two kinds of nanocarriers were characterized in terms of particle size, zeta potential, drug encapsulation efficiency (EE), drug release, and stability. Their in vitro skin permeation was studied using a Franz diffusion cell mounted with depilated mouse skin in vitro. In vivo local anesthetic effects of LA containing formulations were evaluated by tail flick latency (TFL) test using a tail-flick measuring device. Compared with LA-LPs, LA-LPNs showed significantly better in vitro skin permeation ability and in vivo local anesthetic effects. The results demonstrated that LPNs could improve the efficacy of drugs to higher levels than LPs and free drugs, thus could serve as an effective drug system for LA loading for local anesthetic therapy.

Eco-Friendly Acaricidal Effects of Nylon 66 Nanofibers via Grafted Clove Bud Oil-Loaded Capsules on House Dust Mites

PubMed Central

Kim, Seong Hun

2017-01-01

Acaricidal nylon 66 fabrics (AN66Fs) grafted with clove oil-loaded microcapsules (COMCs) were developed against Dermatophagoides farina (D. gallinae). The average diameter was about 2.9 µm with a range of 100 nm–8.5 µm. COMCs carried clove oil loading of about 65 vol %. COMCs were chemically grafted to electrospun nylon nanofibers by the chemical reactions between –OH groups of COMCs and –COOH end groups of nylon fabrics to form ester linkages. AN66Fs had an effect on D. farinae depending on COMCs loadings. The increase in COMCs loading of AN66Fs from 5 to 15 wt % increased from 22% to 93% mortality against D. farinae within 72 h. However, AN66Fs containing over 20 wt % COMCs were more effective, showing up to 100% mortality within 24 h because the large amount of monoterpene alcohol, eugenol. This research suggests the use of clove oil and its major constituent eugenol as eco-friendly bioactive agents that can serve as a replacement for synthetic acaricides in controlling the population of D. farinae. PMID:28698512

Eco-Friendly Acaricidal Effects of Nylon 66 Nanofibers via Grafted Clove Bud Oil-Loaded Capsules on House Dust Mites.

PubMed

Kim, Joo Ran; Kim, Seong Hun

2017-07-10

Acaricidal nylon 66 fabrics (AN66Fs) grafted with clove oil-loaded microcapsules (COMCs) were developed against Dermatophagoides farina ( D. gallinae ). The average diameter was about 2.9 µm with a range of 100 nm-8.5 µm. COMCs carried clove oil loading of about 65 vol %. COMCs were chemically grafted to electrospun nylon nanofibers by the chemical reactions between -OH groups of COMCs and -COOH end groups of nylon fabrics to form ester linkages. AN66Fs had an effect on D. farinae depending on COMCs loadings. The increase in COMCs loading of AN66Fs from 5 to 15 wt % increased from 22% to 93% mortality against D. farinae within 72 h. However, AN66Fs containing over 20 wt % COMCs were more effective, showing up to 100% mortality within 24 h because the large amount of monoterpene alcohol, eugenol. This research suggests the use of clove oil and its major constituent eugenol as eco-friendly bioactive agents that can serve as a replacement for synthetic acaricides in controlling the population of D. farinae .

Discrimination and anger control as pathways linking socioeconomic disadvantage to allostatic load in midlife.

PubMed

Zilioli, Samuele; Imami, Ledina; Ong, Anthony D; Lumley, Mark A; Gruenewald, Tara

2017-12-01

Recent evidence suggests that experiences of discrimination contribute to socioeconomic status health disparities. The current study examined if the experience and regulation of anger-an expected emotional response to discrimination-serves as an explanatory factor for the previously documented links between socioeconomic disadvantage (SED), discrimination, and allostatic load. Data were drawn from the second wave of the Midlife in the United States (MIDUS) study and included 909 adults who participated in the biomarkers subproject. Results revealed that perceived discrimination was associated with higher levels of allostatic load. Furthermore, we found evidence that perceived discrimination and anger control sequentially explained the relationship between SED and allostatic load, such that greater discrimination was associated with lower levels of anger control, which, in turn accounted for the effects of discrimination on allostatic load. These results remained significant after controlling for negative affect, positive affect, other forms of anger expression, as well as demographic covariates. Our findings suggest that low anger control may be an important psychological pathway through which experiences of discrimination influence health. Copyright © 2017 Elsevier Inc. All rights reserved.

Spall damage of a Ta particle-reinforced metallic glass matrix composite under high strain rate loading

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tang, X. C.; Jian, W. R.; Huang, J. Y.

We investigate deformation and damage of a Zr-based bulk metallic glass (BMG) and its Ta particle-reinforced composite (MGMC) under impact loading, as well as quasi-static tension for comparison. Yield strength, spall strength, and damage accumulation rate are obtained from free-surface velocity histories, and MGMC appears to be more damage-resistant. Scanning electron microscopy, electron back scattering diffraction and x-ray computed tomography, are utilized for characterizing microstructures, which show features consistent with macroscopic measurements. Different damage and fracture modes are observed for BMG and MGMC. Multiple well-defined spall planes are observed in BMG, while isolated and scattered cracking around reinforced particles dominatesmore » fracture of MGMC. Particle–matrix interface serves as the source and barrier to crack nucleation and propagation under both quasi-static and impact loading. Finally, deformation twinning and grain refinement play a key role in plastic deformation during shock loading but not in quasi-static loading. In addition, 3D cup-cone structures are resolved in BMG, but not in MGMC due to its heterogeneous stress field.« less

Spall damage of a Ta particle-reinforced metallic glass matrix composite under high strain rate loading

DOE PAGES

Tang, X. C.; Jian, W. R.; Huang, J. Y.; ...

2017-11-11

We investigate deformation and damage of a Zr-based bulk metallic glass (BMG) and its Ta particle-reinforced composite (MGMC) under impact loading, as well as quasi-static tension for comparison. Yield strength, spall strength, and damage accumulation rate are obtained from free-surface velocity histories, and MGMC appears to be more damage-resistant. Scanning electron microscopy, electron back scattering diffraction and x-ray computed tomography, are utilized for characterizing microstructures, which show features consistent with macroscopic measurements. Different damage and fracture modes are observed for BMG and MGMC. Multiple well-defined spall planes are observed in BMG, while isolated and scattered cracking around reinforced particles dominatesmore » fracture of MGMC. Particle–matrix interface serves as the source and barrier to crack nucleation and propagation under both quasi-static and impact loading. Finally, deformation twinning and grain refinement play a key role in plastic deformation during shock loading but not in quasi-static loading. In addition, 3D cup-cone structures are resolved in BMG, but not in MGMC due to its heterogeneous stress field.« less

45 CFR 160.310 - Responsibilities of covered entities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Responsibilities of covered entities. 160.310... Responsibilities of covered entities. (a) Provide records and compliance reports. A covered entity must keep such... entity has complied or is complying with the applicable administrative simplification provisions. (b...

22 CFR 96.103 - Oversight by accrediting entities.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Oversight by accrediting entities. 96.103... Relating to Temporary Accreditation § 96.103 Oversight by accrediting entities. (a) The accrediting entity... agency's application for full accreditation when it is filed. The accrediting entity must also...

43 CFR 426.10 - Public entities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Public entities. 426.10 Section 426.10... INTERIOR ACREAGE LIMITATION RULES AND REGULATIONS § 426.10 Public entities. (a) Application of the acreage limitation provisions to public entities. Reclamation does not subject public entities to the acreage...

22 CFR 96.103 - Oversight by accrediting entities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Oversight by accrediting entities. 96.103... Relating to Temporary Accreditation § 96.103 Oversight by accrediting entities. (a) The accrediting entity... agency's application for full accreditation when it is filed. The accrediting entity must also...

43 CFR 426.10 - Public entities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Public entities. 426.10 Section 426.10... INTERIOR ACREAGE LIMITATION RULES AND REGULATIONS § 426.10 Public entities. (a) Application of the acreage limitation provisions to public entities. Reclamation does not subject public entities to the acreage...

76 FR 78335 - Identification of Additional Entities Pursuant to Executive Order 13469

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-16

... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Identification of Additional Entities... two entities that have been identified as entities in which the Zimbabwe Mining Development.... Therefore, all property and interests in property of such entities are blocked. DATES: The identification by...

45 CFR 160.310 - Responsibilities of covered entities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Responsibilities of covered entities. 160.310... Responsibilities of covered entities. (a) Provide records and compliance reports. A covered entity must keep such... entity has complied or is complying with the applicable administrative simplification provisions. (b...

Diagnostic Algorithm to Reflect Regressive Changes of Human Papilloma Virus in Tissue Biopsies

PubMed Central

Lhee, Min Jin; Cha, Youn Jin; Bae, Jong Man; Kim, Young Tae

2014-01-01

Purpose Landmark indicators have not yet to be developed to detect the regression of cervical intraepithelial neoplasia (CIN). We propose that quantitative viral load and indicative histological criteria can be used to differentiate between atypical squamous cells of undetermined significance (ASCUS) and a CIN of grade 1. Materials and Methods We collected 115 tissue biopsies from women who tested positive for the human papilloma virus (HPV). Nine morphological parameters including nuclear size, perinuclear halo, hyperchromasia, typical koilocyte (TK), abortive koilocyte (AK), bi-/multi-nucleation, keratohyaline granules, inflammation, and dyskeratosis were examined for each case. Correlation analyses, cumulative logistic regression, and binary logistic regression were used to determine optimal cut-off values of HPV copy numbers. The parameters TK, perinuclear halo, multi-nucleation, and nuclear size were significantly correlated quantitatively to HPV copy number. Results An HPV loading number of 58.9 and AK number of 20 were optimal to discriminate between negative and subtle findings in biopsies. An HPV loading number of 271.49 and AK of 20 were optimal for discriminating between equivocal changes and obvious koilocytosis. Conclusion We propose that a squamous epithelial lesion with AK of >20 and quantitative HPV copy number between 58.9-271.49 represents a new spectrum of subtle pathological findings, characterized by AK in ASCUS. This can be described as a distinct entity and called "regressing koilocytosis". PMID:24532500

Human Fetal Membranes at Term: Dead Tissue or Signalers of Parturition?

PubMed Central

MENON, Ramkumar

2017-01-01

Various endocrine, immune, and mechanical factors produced by feto-maternal compartments at term increase intrauterine inflammatory loads to induce labor. The role of fetal (placental) membranes (amniochorion) as providers of parturition signals has not been well investigated. Fetal membranes line the intrauterine cavity and grow with and protect the fetus. Fetal membranes exist as an entity between the mother and fetus and perform unique functions during pregnancy. Membranes undergo a telomere-dependent p38 MAPK-induced senescence and demonstrate a decline in functional and mechanical abilities at term, showing signs of aging. Fetal membrane senescence is also allied with completion of fetal maturation at term as the fetus readies for delivery, which may also indicate the end of independent life and longevity of fetal membranes as their functional role concludes. Fetal membrane senescence is accelerated at term because of oxidative stress and increased stretching. Senescent fetal membranes cells produce senescence-associated secretory phenotype (SASP-inflammation) and also release proinflammatory damage-associated molecular patterns (DAMPs), namely HMGB1 and cell-free fetal telomere fragments. In a feedback loop, SASP and DAMPs increase senescence and enhance the inflammatory load to promote labor. Membranes increase the inflammatory load to disrupt homeostatic balance to transition quiescent uterine tissues toward a labor phenotype. Therefore, along with other well-described labor-promoting signals, senescent fetal membranes may also contribute to human term parturition. PMID:27452431

Human fetal membranes at term: Dead tissue or signalers of parturition?

PubMed

Menon, Ramkumar

2016-08-01

Various endocrine, immune, and mechanical factors produced by feto-maternal compartments at term increase intrauterine inflammatory loads to induce labor. The role of fetal (placental) membranes (amniochorion) as providers of parturition signals has not been well investigated. Fetal membranes line the intrauterine cavity and grow with and protect the fetus. Fetal membranes exist as an entity between the mother and fetus and perform unique functions during pregnancy. Membranes undergo a telomere-dependent p38 MAPK-induced senescence and demonstrate a decline in functional and mechanical abilities at term, showing signs of aging. Fetal membrane senescence is also allied with completion of fetal maturation at term as the fetus readies for delivery, which may also indicate the end of independent life and longevity of fetal membranes as their functional role concludes. Fetal membrane senescence is accelerated at term because of oxidative stress and increased stretching. Senescent fetal membranes cells produce senescence-associated secretory phenotype (SASP-inflammation) and also release proinflammatory damage-associated molecular patterns (DAMPs), namely HMGB1 and cell-free fetal telomere fragments. In a feedback loop, SASP and DAMPs increase senescence and enhance the inflammatory load to promote labor. Membranes increase the inflammatory load to disrupt homeostatic balance to transition quiescent uterine tissues toward a labor phenotype. Therefore, along with other well-described labor-promoting signals, senescent fetal membranes may also contribute to human term parturition. Copyright © 2016 Elsevier Ltd. All rights reserved.

31 CFR 560.305 - Person; entity.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Person; entity. 560.305 Section 560.305 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... § 560.305 Person; entity. (a) The term person means an individual or entity. (b) The term entity means a...

18 CFR 46.5 - Covered entities.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Covered entities. 46.5... FOR PERSONS HOLDING INTERLOCKING POSITIONS § 46.5 Covered entities. Entities to which the general rule..., or a savings and loan association; (b) Any entity which is authorized by law to underwrite or...

45 CFR 162.923 - Requirements for covered entities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Requirements for covered entities. 162.923 Section... Requirements for covered entities. (a) General rule. Except as otherwise provided in this part, if a covered entity conducts, with another covered entity that is required to comply with a transaction standard...

45 CFR 150.307 - Notice to responsible entities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Notice to responsible entities. 150.307 Section... and Non-Federal Governmental Plans-Civil Money Penalties § 150.307 Notice to responsible entities. If... responsible entity or entities identified under § 150.305. The notice does the following: (a) Describes the...

31 CFR 800.211 - Entity.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Entity. 800.211 Section 800.211 Money... FOREIGN PERSONS Definitions § 800.211 Entity. The term entity means any branch, partnership, group or sub... separate legal entity) operated by any one of the foregoing as a business undertaking in a particular...

45 CFR 162.923 - Requirements for covered entities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Requirements for covered entities. 162.923 Section... Requirements for covered entities. (a) General rule. Except as otherwise provided in this part, if a covered entity conducts, with another covered entity that is required to comply with a transaction standard...

46 CFR 67.41 - Governmental entity.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Governmental entity. 67.41 Section 67.41 Shipping COAST... DOCUMENTATION OF VESSELS Citizenship Requirements for Vessel Documentation § 67.41 Governmental entity. A governmental entity is a citizen for the purpose of obtaining a vessel document if it is an entity of the...

46 CFR 67.41 - Governmental entity.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Governmental entity. 67.41 Section 67.41 Shipping COAST... DOCUMENTATION OF VESSELS Citizenship Requirements for Vessel Documentation § 67.41 Governmental entity. A governmental entity is a citizen for the purpose of obtaining a vessel document if it is an entity of the...

18 CFR 46.5 - Covered entities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Covered entities. 46.5... FOR PERSONS HOLDING INTERLOCKING POSITIONS § 46.5 Covered entities. Entities to which the general rule..., or a savings and loan association; (b) Any entity which is authorized by law to underwrite or...

45 CFR 150.307 - Notice to responsible entities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Notice to responsible entities. 150.307 Section... and Non-Federal Governmental Plans-Civil Money Penalties § 150.307 Notice to responsible entities. If... responsible entity or entities identified under § 150.305. The notice does the following: (a) Describes the...

47 CFR 101.1429 - Designated entities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false Designated entities. 101.1429 Section 101.1429... Designated entities. (a) Eligibility for small business provisions. (1) A very small business is an entity... exceeding $3 million for the preceding three years. (2) A small business is an entity that, together with...

42 CFR 6.3 - Eligible entities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Eligible entities. 6.3 Section 6.3 Public Health... COVERAGE OF CERTAIN GRANTEES AND INDIVIDUALS § 6.3 Eligible entities. (a) Grantees. Entities eligible for coverage under this part are public and nonprofit private entities receiving Federal funds under any of the...

31 CFR 560.305 - Person; entity.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Person; entity. 560.305 Section 560.305 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... § 560.305 Person; entity. (a) The term person means an individual or entity. (b) The term entity means a...

42 CFR 6.3 - Eligible entities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Eligible entities. 6.3 Section 6.3 Public Health... COVERAGE OF CERTAIN GRANTEES AND INDIVIDUALS § 6.3 Eligible entities. (a) Grantees. Entities eligible for coverage under this part are public and nonprofit private entities receiving Federal funds under any of the...

12 CFR 1238.7 - Publication of results by regulated entities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Publication of results by regulated entities... TESTING OF REGULATED ENTITIES § 1238.7 Publication of results by regulated entities. (a) Public disclosure of results required for stress tests of regulated entities. The Enterprises must disclose publicly a...

22 CFR 96.5 - Requirement that accrediting entity be a nonprofit or public entity.

Code of Federal Regulations, 2010 CFR

2010-04-01

... administering standards for entities providing child welfare services; or (b) A public entity (other than a... political subdivision, agency, or instrumentality thereof, that is responsible for licensing adoption agencies in a State and that has expertise in developing and administering standards for entities providing...

12 CFR 1237.10 - Limited-life regulated entities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Limited-life regulated entities. 1237.10... RECEIVERSHIP Limited-Life Regulated Entities § 1237.10 Limited-life regulated entities. (a) Status. The United... liquidity portfolio of a limited-life regulated entity. (c) Policies and procedures. The Agency may draft...

12 CFR 1237.10 - Limited-life regulated entities.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Limited-life regulated entities. 1237.10... RECEIVERSHIP Limited-Life Regulated Entities § 1237.10 Limited-life regulated entities. (a) Status. The United... liquidity portfolio of a limited-life regulated entity. (c) Policies and procedures. The Agency may draft...

12 CFR 1237.10 - Limited-life regulated entities.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Limited-life regulated entities. 1237.10... RECEIVERSHIP Limited-Life Regulated Entities § 1237.10 Limited-life regulated entities. (a) Status. The United... liquidity portfolio of a limited-life regulated entity. (c) Policies and procedures. The Agency may draft...

40 CFR 262.216 - Non-laboratory hazardous waste generated at an eligible academic entity.

Code of Federal Regulations, 2012 CFR

2012-07-01

... generated at an eligible academic entity. 262.216 Section 262.216 Protection of Environment ENVIRONMENTAL... Laboratories Owned by Eligible Academic Entities § 262.216 Non-laboratory hazardous waste generated at an eligible academic entity. An eligible academic entity that generates hazardous waste outside of a...

40 CFR 262.216 - Non-laboratory hazardous waste generated at an eligible academic entity.

Code of Federal Regulations, 2010 CFR

2010-07-01

... generated at an eligible academic entity. 262.216 Section 262.216 Protection of Environment ENVIRONMENTAL... Laboratories Owned by Eligible Academic Entities § 262.216 Non-laboratory hazardous waste generated at an eligible academic entity. An eligible academic entity that generates hazardous waste outside of a...

40 CFR 262.216 - Non-laboratory hazardous waste generated at an eligible academic entity.

Code of Federal Regulations, 2013 CFR

2013-07-01

... generated at an eligible academic entity. 262.216 Section 262.216 Protection of Environment ENVIRONMENTAL... Laboratories Owned by Eligible Academic Entities § 262.216 Non-laboratory hazardous waste generated at an eligible academic entity. An eligible academic entity that generates hazardous waste outside of a...

40 CFR 262.216 - Non-laboratory hazardous waste generated at an eligible academic entity.

Code of Federal Regulations, 2014 CFR

2014-07-01

... generated at an eligible academic entity. 262.216 Section 262.216 Protection of Environment ENVIRONMENTAL... Laboratories Owned by Eligible Academic Entities § 262.216 Non-laboratory hazardous waste generated at an eligible academic entity. An eligible academic entity that generates hazardous waste outside of a...

40 CFR 262.216 - Non-laboratory hazardous waste generated at an eligible academic entity.

Code of Federal Regulations, 2011 CFR

2011-07-01

... generated at an eligible academic entity. 262.216 Section 262.216 Protection of Environment ENVIRONMENTAL... Laboratories Owned by Eligible Academic Entities § 262.216 Non-laboratory hazardous waste generated at an eligible academic entity. An eligible academic entity that generates hazardous waste outside of a...

The Effect of Realistic Contexts on Ontological Judgments of Novel Entities

PubMed Central

Van Reet, Jennifer; Pinkham, Ashley M.; Lillard, Angeline S.

2014-01-01

Although a great deal of research has focused on ontological judgments in preschoolers, very little has examined ontological judgments in older children. The present study asked 10-year-olds and adults (N = 94) to judge the reality status of known real, known imagined, and novel entities presented in simple and elaborate contexts and to explain their judgments. Although judgments were generally apt, participants were more likely to endorse imagined and novel entities when the entities were presented in elaborate contexts. When asked to explain their reasoning, participants at both ages cited firsthand experience for real entities and general knowledge for imagined entities. For novel entities, participants referred most to indirect experiences when entities were presented in simple contexts and to general knowledge when those entities were presented in elaborate contexts. These results suggest that rich contextual information continues to be an important influence on ontological judgments past the preschool years. PMID:25914442

Relatedness-based Multi-Entity Summarization

PubMed Central

Gunaratna, Kalpa; Yazdavar, Amir Hossein; Thirunarayan, Krishnaprasad; Sheth, Amit; Cheng, Gong

2017-01-01

Representing world knowledge in a machine processable format is important as entities and their descriptions have fueled tremendous growth in knowledge-rich information processing platforms, services, and systems. Prominent applications of knowledge graphs include search engines (e.g., Google Search and Microsoft Bing), email clients (e.g., Gmail), and intelligent personal assistants (e.g., Google Now, Amazon Echo, and Apple’s Siri). In this paper, we present an approach that can summarize facts about a collection of entities by analyzing their relatedness in preference to summarizing each entity in isolation. Specifically, we generate informative entity summaries by selecting: (i) inter-entity facts that are similar and (ii) intra-entity facts that are important and diverse. We employ a constrained knapsack problem solving approach to efficiently compute entity summaries. We perform both qualitative and quantitative experiments and demonstrate that our approach yields promising results compared to two other stand-alone state-of-the-art entity summarization approaches. PMID:29051696

The Effect of Realistic Contexts on Ontological Judgments of Novel Entities.

PubMed

Van Reet, Jennifer; Pinkham, Ashley M; Lillard, Angeline S

2015-01-01

Although a great deal of research has focused on ontological judgments in preschoolers, very little has examined ontological judgments in older children. The present study asked 10-year-olds and adults (N = 94) to judge the reality status of known real, known imagined, and novel entities presented in simple and elaborate contexts and to explain their judgments. Although judgments were generally apt, participants were more likely to endorse imagined and novel entities when the entities were presented in elaborate contexts. When asked to explain their reasoning, participants at both ages cited firsthand experience for real entities and general knowledge for imagined entities. For novel entities, participants referred most to indirect experiences when entities were presented in simple contexts and to general knowledge when those entities were presented in elaborate contexts. These results suggest that rich contextual information continues to be an important influence on ontological judgments past the preschool years.

Biaxial deformation of collagen and elastin fibers in coronary adventitia

PubMed Central

Chen, Huan; Slipchenko, Mikhail N.; Liu, Yi; Zhao, Xuefeng; Cheng, Ji-Xin; Lanir, Yoram

2013-01-01

The microstructural deformation-mechanical loading relation of the blood vessel wall is essential for understanding the overall mechanical behavior of vascular tissue in health and disease. We employed simultaneous mechanical loading-imaging to quantify in situ deformation of individual collagen and elastin fibers on unstained fresh porcine coronary adventitia under a combination of vessel inflation and axial extension loading. Specifically, the specimens were imaged under biaxial loads to study microscopic deformation-loading behavior of fibers in conjunction with morphometric measurements at the zero-stress state. Collagen fibers largely orientate in the longitudinal direction, while elastin fibers have major orientation parallel to collagen, but with additional orientation angles in each sublayer of the adventitia. With an increase of biaxial load, collagen fibers were uniformly stretched to the loading direction, while elastin fibers gradually formed a network in sublayers, which strongly depended on the initial arrangement. The waviness of collagen decreased more rapidly at a circumferential stretch ratio of λθ = 1.0 than at λθ = 1.5, while most collagen became straightened at λθ = 1.8. These microscopic deformations imply that the longitudinally stiffer adventitia is a direct result of initial fiber alignment, and the overall mechanical behavior of the tissue is highly dependent on the corresponding microscopic deformation of fibers. The microstructural deformation-loading relation will serve as a foundation for micromechanical models of the vessel wall. PMID:24092692

Effects of high-heeled shoes and asymmetrical load carrying on lower-extremity kinematics during walking in young women.

PubMed

Lee, Soul; Li, Jing Xian

2014-01-01

Asymmetrical load carrying and wearing high-heeled shoes are very common. Biomechanics studies on the combined effects of high-heeled shoe wearing and asymmetrical load carrying are lacking. We sought to identify changes in lower-extremity joint kinematics associated with the effect of shoes and asymmetrical load carrying during walking. Fifteen healthy young women (mean ± SD: age, 24.67 ± 3.54 years; body weight, 54.96 ± 6.67 kg; and height, 162.2 ± 3.91 cm) who habitually wore high-heeled shoes participated in the study. They were asked to walk under nine combined conditions of three heights of shoe heels (0, 3, and 9 cm) and three carried loads (0%, 5%, and 10% of body weight). Temporospatial parameters and maximal joint angles in the sagittal and frontal planes of the hip, knee, and ankle on both limbs were studied. It was found that high-heeled shoe wearing and asymmetrical load carrying altered temporospatial parameters and joint kinematics. With increased heel height and load weight, cadence decreased and stride length increased. The knee flexion angle increased with an increase in heel height, and the load served only to exacerbate the changes. Changes in the hip angle were mostly caused by asymmetrical load carrying, whereas angle changes in the ankle were mostly caused by an increase in heel height. This study demonstrated that when high-heeled shoe wearing and asymmetrical load carrying are combined, changes at each joint are much greater than with high-heeled shoe wearing or load carrying alone.

Pregaming: A High-Risk Behavior. Prevention Update

ERIC Educational Resources Information Center

Higher Education Center for Alcohol, Drug Abuse, and Violence Prevention, 2010

2010-01-01

"Pregaming" or "pre-loading" is what college students call the practice of drinking alcohol in a private setting prior to attending an organized event or social activity where alcohol might or might not be served. According to one student, "Pregames are usually a fun part of the night because you're just with a few close…

Comparing IndexedHBase and Riak for Serving Truthy: Performance of Data Loading and Query Evaluation

DTIC Science & Technology

2013-08-01

Research Triangle Park, NC 27709-2211 15. SUBJECT TERMS performance evaluation, distributed database, noSQL , HBase, indexing Xiaoming Gao, Judy Qiu...common hashtags created during a given time window. With the purpose of finding a solution for these challenges, we evaluate NoSQL databases such as

Holistic Support That Promotes Student Learning

ERIC Educational Resources Information Center

Dennis, Sophie Lampard; Osterholt, Dorothy A.

2011-01-01

For decades, the cost of serving college students, from community colleges to Ivy League institutions, has been a barrier that has blocked access for many who want an education. With a recent massification effort aimed at producing more college graduates for the workplace, the enrollment numbers have increased and student debt load has become a…

Rugged microelectronic module package supports circuitry on heat sink

NASA Technical Reports Server (NTRS)

Johnson, A. L.

1966-01-01

Rugged module package for thin film hybrid microcircuits incorporated a rigid, thermally conductive support structure, which serves as a heat sink, and a lead wire block in which T-shaped electrical connectors are potted. It protects the circuitry from shock and vibration loads, dissipates internal heat, and simplifies electrical connections between adjacent modules.

A combined upflow anaerobic sludge bed and trickling biofilter process for the treatment of swine wastewater.

PubMed

Zhao, Bowei; Li, Jiangzheng; Buelna, Gerardo; Dubé, Rino; Le Bihan, Yann

2016-01-01

A combined upflow anaerobic sludge blanket (UASB)-trickling biofilter (TBF) process was constructed to treat swine wastewater, a typical high-strength organic wastewater with low carbon/nitrogen ratio and ammonia toxicity. The results showed that the UASB-TBF system can remarkably enhance the removal of pollutants in the swine wastewater. At an organic loading rate of 2.29 kg/m(3) d and hydraulic retention time of 48 h in the UASB, the chemical oxygen demand (COD), Suspended Solids and Total Kjeldahl Nitrogen removals of the combined process reached 83.6%, 84.1% and 41.2%, respectively. In the combined system the UASB served as a pretreatment process for COD removal while nitrification and denitrification occurred only in the TBF process. The TBF performed reasonably well at a surface hydraulic load as high as 0.12 m(3)/m(2) d. Since the ratio of influent COD to total mineral nitrogen was less than 3.23, it is reasonable to suggest that the wood chips in TBF can serve as a new carbon source for denitrification.

Optimized design and control of an off grid solar PV/hydrogen fuel cell power system for green buildings

NASA Astrophysics Data System (ADS)

Ghenai, C.; Bettayeb, M.

2017-11-01

Modelling, simulation, optimization and control strategies are used in this study to design a stand-alone solar PV/Fuel Cell/Battery/Generator hybrid power system to serve the electrical load of a commercial building. The main objective is to design an off grid energy system to meet the desired electric load of the commercial building with high renewable fraction, low emissions and low cost of energy. The goal is to manage the energy consumption of the building, reduce the associate cost and to switch from grid-tied fossil fuel power system to an off grid renewable and cleaner power system. Energy audit was performed in this study to determine the energy consumption of the building. Hourly simulations, modelling and optimization were performed to determine the performance and cost of the hybrid power configurations using different control strategies. The results show that the hybrid off grid solar PV/Fuel Cell/Generator/Battery/Inverter power system offers the best performance for the tested system architectures. From the total energy generated from the off grid hybrid power system, 73% is produced from the solar PV, 24% from the fuel cell and 3% from the backup Diesel generator. The produced power is used to meet all the AC load of the building without power shortage (<0.1%). The hybrid power system produces 18.2% excess power that can be used to serve the thermal load of the building. The proposed hybrid power system is sustainable, economically viable and environmentally friendly: High renewable fraction (66.1%), low levelized cost of energy (92 /MWh), and low carbon dioxide emissions (24 kg CO2/MWh) are achieved.

Enhancement of Chemical Entity Identification in Text Using Semantic Similarity Validation

PubMed Central

Grego, Tiago; Couto, Francisco M.

2013-01-01

With the amount of chemical data being produced and reported in the literature growing at a fast pace, it is increasingly important to efficiently retrieve this information. To tackle this issue text mining tools have been applied, but despite their good performance they still provide many errors that we believe can be filtered by using semantic similarity. Thus, this paper proposes a novel method that receives the results of chemical entity identification systems, such as Whatizit, and exploits the semantic relationships in ChEBI to measure the similarity between the entities found in the text. The method assigns a single validation score to each entity based on its similarities with the other entities also identified in the text. Then, by using a given threshold, the method selects a set of validated entities and a set of outlier entities. We evaluated our method using the results of two state-of-the-art chemical entity identification tools, three semantic similarity measures and two text window sizes. The method was able to increase precision without filtering a significant number of correctly identified entities. This means that the method can effectively discriminate the correctly identified chemical entities, while discarding a significant number of identification errors. For example, selecting a validation set with 75% of all identified entities, we were able to increase the precision by 28% for one of the chemical entity identification tools (Whatizit), maintaining in that subset 97% the correctly identified entities. Our method can be directly used as an add-on by any state-of-the-art entity identification tool that provides mappings to a database, in order to improve their results. The proposed method is included in a freely accessible web tool at www.lasige.di.fc.ul.pt/webtools/ice/. PMID:23658791

One Idea for a Next Generation Shuttle

NASA Technical Reports Server (NTRS)

MacConochie, Ian O.; Cerro, Jeffrey A.

2004-01-01

In this configuration, the current Shuttle External Tank serves as core structure for a fully reusable second stage. This stage is equipped with wings, vertical fin, landing gear, and thermal protection. The stage is geometrically identical to (but smaller than) a single stage that has been tested hyper-sonically, super-sonically, and sub-sonically in the NASA Langley Research Center wind tunnels. The three LOX/LH engines that currently serve as main propulsion for the Shuttle Orbiter, serve as main propulsion on the new stage. The new stage is unmanned but is equipped with the avionics needed for automatic maneuvering on orbit and for landing on a runway. Three rails are installed along the top surface of the vehicle for attachment of various payloads. Pay- loads might include third stages with satellites attached, personnel pods, propellants, or other items.

12 CFR 1238.6 - Post-assessment actions by regulated entities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Post-assessment actions by regulated entities... TESTING OF REGULATED ENTITIES § 1238.6 Post-assessment actions by regulated entities. Each regulated entity shall take the results of the stress test conducted under § 1238.3 into account in making changes...