The Effect of Perceptual Load on Attention-Induced Motion Blindness: The Efficiency of Selective Inhibition

ERIC Educational Resources Information Center

Hay, Julia L.; Milders, Maarten M.; Sahraie, Arash; Niedeggen, Michael

2006-01-01

Recent visual marking studies have shown that the carry-over of distractor inhibition can impair the ability of singletons to capture attention if the singleton and distractors share features. The current study extends this finding to first-order motion targets and distractors, clearly separated in time by a visual cue (the letter X). Target…

The effect of perceptual load on attention-induced motion blindness: the efficiency of selective inhibition.

PubMed

Hay, Julia L; Milders, Maarten M; Sahraie, Arash; Niedeggen, Michael

2006-08-01

Recent visual marking studies have shown that the carry-over of distractor inhibition can impair the ability of singletons to capture attention if the singleton and distractors share features. The current study extends this finding to first-order motion targets and distractors, clearly separated in time by a visual cue (the letter X). Target motion discrimination was significantly impaired, a result attributed to the carry-over of distractor inhibition. Increasing the difficulty of cue detection increased the motion target impairment, as distractor inhibition is thought to increase under demanding (high load) conditions in order to maximize selection efficiency. The apparent conflict with studies reporting reduced distractor inhibition under high load conditions was resolved by distinguishing between the effects of "cognitive" and "perceptual" load. ((c) 2006 APA, all rights reserved).

Research on parallel load sharing principle of piezoelectric six-dimensional heavy force/torque sensor

NASA Astrophysics Data System (ADS)

Liu, Wei; Li, Ying-jun; Jia, Zhen-yuan; Zhang, Jun; Qian, Min

2011-01-01

In working process of huge heavy-load manipulators, such as the free forging machine, hydraulic die-forging press, forging manipulator, heavy grasping manipulator, large displacement manipulator, measurement of six-dimensional heavy force/torque and real-time force feedback of the operation interface are basis to realize coordinate operation control and force compliance control. It is also an effective way to raise the control accuracy and achieve highly efficient manufacturing. Facing to solve dynamic measurement problem on six-dimensional time-varying heavy load in extremely manufacturing process, the novel principle of parallel load sharing on six-dimensional heavy force/torque is put forward. The measuring principle of six-dimensional force sensor is analyzed, and the spatial model is built and decoupled. The load sharing ratios are analyzed and calculated in vertical and horizontal directions. The mapping relationship between six-dimensional heavy force/torque value to be measured and output force value is built. The finite element model of parallel piezoelectric six-dimensional heavy force/torque sensor is set up, and its static characteristics are analyzed by ANSYS software. The main parameters, which affect load sharing ratio, are analyzed. The experiments for load sharing with different diameters of parallel axis are designed. The results show that the six-dimensional heavy force/torque sensor has good linearity. Non-linearity errors are less than 1%. The parallel axis makes good effect of load sharing. The larger the diameter is, the better the load sharing effect is. The results of experiments are in accordance with the FEM analysis. The sensor has advantages of large measuring range, good linearity, high inherent frequency, and high rigidity. It can be widely used in extreme environments for real-time accurate measurement of six-dimensional time-varying huge loads on manipulators.

Effects of Peer-Tutor Competences on Learner Cognitive Load and Learning Performance during Knowledge Sharing

ERIC Educational Resources Information Center

Hsiao, Ya-Ping; Brouns, Francis; van Bruggen, Jan; Sloep, Peter B.

2012-01-01

In Learning Networks, learners need to share knowledge with others to build knowledge. In particular, when working on complex tasks, they often need to acquire extra cognitive resources from others to process a high task load. However, without support high task load and organizing knowledge sharing themselves might easily overload learners'…

In vitro evaluation of translating and rotating plates using a robot testing system under follower load.

PubMed

Yan, Y; Bell, K M; Hartman, R A; Hu, J; Wang, W; Kang, J D; Lee, J Y

2017-01-01

Various modifications to standard "rigid" anterior cervical plate designs (constrained plate) have been developed that allow for some degree of axial translation and/or rotation of the plate (semi-constrained plate)-theoretically promoting proper load sharing with the graft and improved fusion rates. However, previous studies about rigid and dynamic plates have not examined the influence of simulated muscle loading. The objective of this study was to compare rigid, translating, and rotating plates for single-level corpectomy procedures using a robot testing system with follower load. In-vitro biomechanical test. N = 15 fresh-frozen human (C3-7) cervical specimens were biomechanically tested. The follower load was applied to the specimens at the neutral position from 0 to 100 N. Specimens were randomized into a rigid plate group, a translating plate group and a rotating plate group and then tested in flexion, extension, lateral bending and axial rotation to a pure moment target of 2.0 Nm under 100N of follower load. Range of motion, load sharing, and adjacent level effects were analyzed using a repeated measures analysis of variance (ANOVA). No significant differences were observed between the translating plate and the rigid plate on load sharing at neutral position and C4-6 ROM, but the translating plate was able to maintain load through the graft at a desired level during flexion. The rotating plate shared less load than rigid and translating plates in the neutral position, but cannot maintain the graft load during flexion. This study demonstrated that, in the presence of simulated muscle loading (follower load), the translating plate demonstrated superior performance for load sharing compared to the rigid and rotating plates.

Malaligned dynamic anterior cervical plate: a biomechanical analysis of effectiveness.

PubMed

Lawrence, Brandon D; Patel, Alpesh A; Guss, Andrew; Ryan Spiker, W; Brodke, Darrel S

2014-12-01

Biomechanical evaluation. To evaluate the kinematic and load-sharing differences of dynamic anterior cervical plates when placed in-line at 0° and off-axis at 20°. The use of dynamic anterior cervical plating systems has recently gained popularity due to the theoretical benefit of improved load sharing with graft subsidence. Occasionally, due to anatomical restraints, the anterior cervical plate may be placed off-axis in the coronal plane. This may potentially decrease the dynamization capability of the plate, leading to less load sharing and potentially decreased fusion rates. The purpose of this study was to comprehensively evaluate the kinematic and load-sharing differences of a dynamic plate placed in-line versus off-axis in the coronal plane. Thirteen fresh-frozen human cadaveric cervical spines (C2-T1) were used. Nondestructive range-of-motion testing was performed with a pneumatically controlled spine simulator in flexion/extension, lateral bending, and axial rotation using the OptoTrak motion measurement system. A C5 corpectomy was performed, and a custom interbody spacer with an integrated load cell collected load-sharing data under axial compression at varying loads. A dynamic anterior cervical plate was placed in-line at 0° and then off-axis at 20°. Testing conditions ensued using a full-length spacer, followed by simulated subsidence by removing 10% of the height of the original spacer. There were no kinematic differences noted in the in-line model versus the off-axis model. After simulated subsidence, the small decreases in stiffness and increases in motion were similar whether the plate was placed in-line or off-axis in all 3 planes of motion. There were also no significant differences in the load-sharing characteristics of the in-line plate versus the off-axis plate in either the full-length model or the subsided interbody model. This study suggests that off-axis dynamic plate positioning does not significantly impact construct kinematics or graft load sharing. As such, we do not recommend removal or repositioning of an off-axis placed dynamic plate because the kinematic and load-sharing biomechanical properties are similar. N/A.

Load-sharing through elastic micro-motion accelerates bone formation and interbody fusion.

PubMed

Ledet, Eric H; Sanders, Glenn P; DiRisio, Darryl J; Glennon, Joseph C

2018-02-13

Achieving a successful spinal fusion requires the proper biological and biomechanical environment. Optimizing load-sharing in the interbody space can enhance bone formation. For anterior cervical discectomy and fusion (ACDF), loading and motion are largely dictated by the stiffness of the plate, which can facilitate a balance between stability and load-sharing. The advantages of load-sharing may be substantial for patients with comorbidities and in multilevel procedures where pseudarthrosis rates are significant. We aimed to evaluate the efficacy of a novel elastically deformable, continuously load-sharing anterior cervical spinal plate for promotion of bone formation and interbody fusion relative to a translationally dynamic plate. An in vivo animal model was used to evaluate the effects of an elastically deformable spinal plate on bone formation and spine fusion. Fourteen goats underwent an ACDF and received either a translationally dynamic or elastically deformable plate. Animals were followed up until 18 weeks and were evaluated by plain x-ray, computed tomography scan, and undecalcified histology to evaluate the rate and quality of bone formation and interbody fusion. Animals treated with the elastically deformable plate demonstrated statistically significantly superior early bone formation relative to the translationally dynamic plate. Trends in the data from 8 to 18 weeks postoperatively suggest that the elastically deformable implant enhanced bony bridging and fusion, but these enhancements were not statistically significant. Load-sharing through elastic micro-motion accelerates bone formation in the challenging goat ACDF model. The elastically deformable implant used in this study may promote early bony bridging and increased rates of fusion, but future studies will be necessary to comprehensively characterize the advantages of load-sharing through micro-motion. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Planetary Load Sharing in Three-Point Mounted Wind Turbine Gearboxes: A Design and Test Comparison

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keller, Jonathan; Guo, Yi; Zhang, Zhiwei

This work compares the planetary load-sharing characteristics of wind turbine gearboxes supported by cylindrical roller bearings (CRBs) and preloaded tapered roller bearings (TRBs) when subjected to rotor moments. Planetary bearing loads were measured in field-representative dynamometer tests and compared to loads predicted by finite-element models. Preloaded TRBs significantly improved load sharing. In pure torque conditions, the upwind planet bearing load in the gearbox with preloaded TRBs was only 14% more than the assumed load compared to 47% more for the gearbox with CRBs. Consequently, the predicted fatigue life of the complete set of planetary bearings for the gearbox with preloadedmore » TRBs is 3.5 times greater than that of the gearbox with CRBs.« less

Patellar fixation protected with a load-sharing cable: a mechanical and clinical study.

PubMed

Perry, C R; McCarthy, J A; Kain, C C; Pearson, R L

1988-01-01

The stability of patellar fracture fixation protected with a load-sharing cable was studied in cadavers. A transverse patellar osteotomy was produced and stabilized with standard patellar fixation with or without a figure-of-eight cable that extends from the proximal pole of the patella to the tibial tubercle. Standard fixation techniques (interfragmentary cancellous screws or modified tension-band wiring) alone failed after significantly fewer cycles of flexion and extension than did the same fixation when supplemented with a load-sharing cable. In the clinical evaluation of the load-sharing cable, 14 consecutive patients with displaced patellar fractures were treated. No immobilization was used and the patients were started on passive and active range of motion and weight-bearing ambulation in the early postoperative period. Thirteen fractures healed uneventfully. The increased stability of patellar fracture fixation protected with a load-sharing cable offers three advantages: (a) adjunctive casting is unnecessary, (b) comminuted fractures can be "pieced" together anatomically with less concern for loss of fixation, and (c) early postoperative passive and active range of motion can be achieved.

Self-organized dynamics in local load-sharing fiber bundle models.

PubMed

Biswas, Soumyajyoti; Chakrabarti, Bikas K

2013-10-01

We study the dynamics of a local load-sharing fiber bundle model in two dimensions under an external load (which increases with time at a fixed slow rate) applied at a single point. Due to the local load-sharing nature, the redistributed load remains localized along the boundary of the broken patch. The system then goes to a self-organized state with a stationary average value of load per fiber along the (increasing) boundary of the broken patch (damaged region) and a scale-free distribution of avalanche sizes and other related quantities are observed. In particular, when the load redistribution is only among nearest surviving fiber(s), the numerical estimates of the exponent values are comparable with those of the Manna model. When the load redistribution is uniform along the patch boundary, the model shows a simple mean-field limit of this self-organizing critical behavior, for which we give analytical estimates of the saturation load per fiber values and avalanche size distribution exponent. These are in good agreement with numerical simulation results.

Attention and Visuospatial Working Memory Share the Same Processing Resources

PubMed Central

Feng, Jing; Pratt, Jay; Spence, Ian

2012-01-01

Attention and visuospatial working memory (VWM) share very similar characteristics; both have the same upper bound of about four items in capacity and they recruit overlapping brain regions. We examined whether both attention and VWM share the same processing resources using a novel dual-task costs approach based on a load-varying dual-task technique. With sufficiently large loads on attention and VWM, considerable interference between the two processes was observed. A further load increase on either process produced reciprocal increases in interference on both processes, indicating that attention and VWM share common resources. More critically, comparison among four experiments on the reciprocal interference effects, as measured by the dual-task costs, demonstrates no significant contribution from additional processing other than the shared processes. These results support the notion that attention and VWM share the same processing resources. PMID:22529826

Expert Systems on Multiprocessor Architectures. Volume 3. Technical Reports

DTIC Science & Technology

1991-06-01

choice of load balancing vs. load sharing 1141. While load balancing strives to keep all sites equally loaded, load sharing merely tries to prevent ...unnecessary idleness. Loo. balancing is appropriate to object- oriented real- time systems because * real-time systems ne ,l to prevent long waits for...oetavir ConClass siy51cr Iz a n ubjeU rephitation ’-enare ir order wo prevent a partic=Lar abiec:;ram heing (ntrlu ~lel Ar iic]en:f etautaan ire chanw

Effects of inter-individual lumbar spine geometry variation on load-sharing: Geometrically personalized Finite Element study.

PubMed

Naserkhaki, Sadegh; Jaremko, Jacob L; El-Rich, Marwan

2016-09-06

There is a large, at times contradictory, body of research relating spinal curvature to Low Back Pain (LBP). Mechanical load is considered as important factor in LBP etiology. Geometry of the spinal structures and sagittal curvature of the lumbar spine govern its mechanical behavior. Thus, understanding how inter-individual geometry particularly sagittal curvature variation affects the spinal load-sharing becomes of high importance in LBP assessment. This study calculated and compared kinematics and load-sharing in three ligamentous lumbosacral spines: one hypo-lordotic (Hypo-L) with low lordosis, one normal-lordotic (Norm-L) with normal lordosis, and one hyper-lordotic (Hyper-L) with high lordosis in flexed and extended postures using 3D nonlinear Finite Element (FE) modeling. These postures were simulated by applying Follower Load (FL) combined with flexion or extension moment. The Hypo-L spine demonstrated stiffer behavior in flexion but more flexible response to extension compared to the Norm-L spine. The excessive lordosis stiffened response of the Hyper-L spine to extension but did not affect its resistance to flexion compared to the Norm-L spine. Despite the different resisting actions of the posterior ligaments to flexion moment, the increase of disc compression was similar in all the spines leading to similar load-sharing. However, resistance of the facet joints to extension was more important in the Norm- and Hyper-L spines which reduced the disc compression. The spinal curvature strongly influenced the magnitude and location of load on the spinal components and also altered the kinematics and load-sharing particularly in extension. Consideration of the subject-specific geometry and sagittal curvature should be an integral part of mechanical analysis of the lumbar spine. Copyright © 2016 Elsevier Ltd. All rights reserved.

Effect of perceptual load on conceptual processing: an extension of Vermeulen's theory.

PubMed

Xie, Jiushu; Wang, Ruiming; Sun, Xun; Chang, Song

2013-10-01

The effect of color and shape load on conceptual processing was studied. Perceptual load effects have been found in visual and auditory conceptual processing, supporting the theory of embodied cognition. However, whether different types of visual concepts, such as color and shape, share the same perceptual load effects is unknown. In the current experiment, 32 participants were administered simultaneous perceptual and conceptual tasks to assess the relation between perceptual load and conceptual processing. Keeping color load in mind obstructed color conceptual processing. Hence, perceptual processing and conceptual load shared the same resources, suggesting embodied cognition. Color conceptual processing was not affected by shape pictures, indicating that different types of properties within vision were separate.

Concurrent working memory load can facilitate selective attention: evidence for specialized load.

PubMed

Park, Soojin; Kim, Min-Shik; Chun, Marvin M

2007-10-01

Load theory predicts that concurrent working memory load impairs selective attention and increases distractor interference (N. Lavie, A. Hirst, J. W. de Fockert, & E. Viding). Here, the authors present new evidence that the type of concurrent working memory load determines whether load impairs selective attention or not. Working memory load was paired with a same/different matching task that required focusing on targets while ignoring distractors. When working memory items shared the same limited-capacity processing mechanisms with targets in the matching task, distractor interference increased. However, when working memory items shared processing with distractors in the matching task, distractor interference decreased, facilitating target selection. A specialized load account is proposed to describe the dissociable effects of working memory load on selective processing depending on whether the load overlaps with targets or with distractors. (c) 2007 APA

Simulation of load-sharing in standalone distributed generation system

NASA Astrophysics Data System (ADS)

Ajewole, Titus O.; Craven, Robert P. M.; Kayode, Olakunle; Babalola, Olufisayo S.

2018-05-01

This paper presents a study on load-sharing among the component generating units of a multi-source electric microgrid that is operated as an autonomous ac supply-mode system. Emerging trend in power system development permits deployment of microgrids for standalone or stand-by applications, thereby requiring active- and reactive power sharing among the discrete generating units contained in hybrid-source microgrids. In this study, therefore, a laboratory-scale model of a microgrid energized with three renewable energy-based sources is employed as a simulation platform to investigate power sharing among the power-generating units. Each source is represented by a source emulator that captures the real operational characteristics of the mimicked generating unit and, with implementation of real-life weather data and load profiles on the model; the sharing of the load among the generating units is investigated. There is a proportionate generation of power by the three source emulators, with their frequencies perfectly synchronized at the point of common coupling as a result of balance flow of power among them. This hybrid topology of renewable energy-based microgrid could therefore be seamlessly adapted into national energy mix by the indigenous electric utility providers in Nigeria.

Reducing persistent polyomavirus infection increases functionality of virus-specific memory CD8 T cells.

PubMed

Qin, Qingsong; Lauver, Matthew; Maru, Saumya; Lin, Eugene; Lukacher, Aron E

2017-02-01

Mouse polyomavirus (MuPyV) causes a smoldering persistent infection in immunocompetent mice. To lower MuPyV infection in acutely and persistently infected mice, and study the impact of a temporal reduction in viral loads on the memory CD8 T cell response, we created a recombinant MuPyV in which a loxP sequence was inserted into the A2 strain genome upstream of the early promoter and another loxP sequence was inserted in cis into the intron shared by all three T antigens. Using mice transgenic for tamoxifen-inducible Cre recombinase, we demonstrated that reduction in MuPyV load during persistent infection was associated with differentiation of virus-specific CD8 T cells having a superior recall response. Evidence presented here supports the concept that reduction in viral load during persistent infection can promote differentiation of protective virus-specific memory CD8 T cells in patients at risk for diseases caused by human polyomaviruses. Copyright © 2016 Elsevier Inc. All rights reserved.

Analysis of dynamic behavior of multiple-stage planetary gear train used in wind driven generator.

PubMed

Wang, Jungang; Wang, Yong; Huo, Zhipu

2014-01-01

A dynamic model of multiple-stage planetary gear train composed of a two-stage planetary gear train and a one-stage parallel axis gear is proposed to be used in wind driven generator to analyze the influence of revolution speed and mesh error on dynamic load sharing characteristic based on the lumped parameter theory. Dynamic equation of the model is solved using numerical method to analyze the uniform load distribution of the system. It is shown that the load sharing property of the system is significantly affected by mesh error and rotational speed; load sharing coefficient and change rate of internal and external meshing of the system are of obvious difference from each other. The study provides useful theoretical guideline for the design of the multiple-stage planetary gear train of wind driven generator.

Analysis of Dynamic Behavior of Multiple-Stage Planetary Gear Train Used in Wind Driven Generator

PubMed Central

Wang, Jungang; Wang, Yong; Huo, Zhipu

2014-01-01

A dynamic model of multiple-stage planetary gear train composed of a two-stage planetary gear train and a one-stage parallel axis gear is proposed to be used in wind driven generator to analyze the influence of revolution speed and mesh error on dynamic load sharing characteristic based on the lumped parameter theory. Dynamic equation of the model is solved using numerical method to analyze the uniform load distribution of the system. It is shown that the load sharing property of the system is significantly affected by mesh error and rotational speed; load sharing coefficient and change rate of internal and external meshing of the system are of obvious difference from each other. The study provides useful theoretical guideline for the design of the multiple-stage planetary gear train of wind driven generator. PMID:24511295

Controllable load sharing for soft adhesive interfaces on three-dimensional surfaces.

PubMed

Song, Sukho; Drotlef, Dirk-Michael; Majidi, Carmel; Sitti, Metin

2017-05-30

For adhering to three-dimensional (3D) surfaces or objects, current adhesion systems are limited by a fundamental trade-off between 3D surface conformability and high adhesion strength. This limitation arises from the need for a soft, mechanically compliant interface, which enables conformability to nonflat and irregularly shaped surfaces but significantly reduces the interfacial fracture strength. In this work, we overcome this trade-off with an adhesion-based soft-gripping system that exhibits enhanced fracture strength without sacrificing conformability to nonplanar 3D surfaces. Composed of a gecko-inspired elastomeric microfibrillar adhesive membrane supported by a pressure-controlled deformable gripper body, the proposed soft-gripping system controls the bonding strength by changing its internal pressure and exploiting the mechanics of interfacial equal load sharing. The soft adhesion system can use up to ∼26% of the maximum adhesion of the fibrillar membrane, which is 14× higher than the adhering membrane without load sharing. Our proposed load-sharing method suggests a paradigm for soft adhesion-based gripping and transfer-printing systems that achieves area scaling similar to that of a natural gecko footpad.

Controllable load sharing for soft adhesive interfaces on three-dimensional surfaces

NASA Astrophysics Data System (ADS)

Song, Sukho; Drotlef, Dirk-Michael; Majidi, Carmel; Sitti, Metin

2017-05-01

For adhering to three-dimensional (3D) surfaces or objects, current adhesion systems are limited by a fundamental trade-off between 3D surface conformability and high adhesion strength. This limitation arises from the need for a soft, mechanically compliant interface, which enables conformability to nonflat and irregularly shaped surfaces but significantly reduces the interfacial fracture strength. In this work, we overcome this trade-off with an adhesion-based soft-gripping system that exhibits enhanced fracture strength without sacrificing conformability to nonplanar 3D surfaces. Composed of a gecko-inspired elastomeric microfibrillar adhesive membrane supported by a pressure-controlled deformable gripper body, the proposed soft-gripping system controls the bonding strength by changing its internal pressure and exploiting the mechanics of interfacial equal load sharing. The soft adhesion system can use up to ˜26% of the maximum adhesion of the fibrillar membrane, which is 14× higher than the adhering membrane without load sharing. Our proposed load-sharing method suggests a paradigm for soft adhesion-based gripping and transfer-printing systems that achieves area scaling similar to that of a natural gecko footpad.

Controllable load sharing for soft adhesive interfaces on three-dimensional surfaces

PubMed Central

Song, Sukho; Drotlef, Dirk-Michael; Majidi, Carmel; Sitti, Metin

2017-01-01

For adhering to three-dimensional (3D) surfaces or objects, current adhesion systems are limited by a fundamental trade-off between 3D surface conformability and high adhesion strength. This limitation arises from the need for a soft, mechanically compliant interface, which enables conformability to nonflat and irregularly shaped surfaces but significantly reduces the interfacial fracture strength. In this work, we overcome this trade-off with an adhesion-based soft-gripping system that exhibits enhanced fracture strength without sacrificing conformability to nonplanar 3D surfaces. Composed of a gecko-inspired elastomeric microfibrillar adhesive membrane supported by a pressure-controlled deformable gripper body, the proposed soft-gripping system controls the bonding strength by changing its internal pressure and exploiting the mechanics of interfacial equal load sharing. The soft adhesion system can use up to ∼26% of the maximum adhesion of the fibrillar membrane, which is 14× higher than the adhering membrane without load sharing. Our proposed load-sharing method suggests a paradigm for soft adhesion-based gripping and transfer-printing systems that achieves area scaling similar to that of a natural gecko footpad. PMID:28507143

Reliability demonstration test for load-sharing systems with exponential and Weibull components

PubMed Central

Hu, Qingpei; Yu, Dan; Xie, Min

2017-01-01

Conducting a Reliability Demonstration Test (RDT) is a crucial step in production. Products are tested under certain schemes to demonstrate whether their reliability indices reach pre-specified thresholds. Test schemes for RDT have been studied in different situations, e.g., lifetime testing, degradation testing and accelerated testing. Systems designed with several structures are also investigated in many RDT plans. Despite the availability of a range of test plans for different systems, RDT planning for load-sharing systems hasn’t yet received the attention it deserves. In this paper, we propose a demonstration method for two specific types of load-sharing systems with components subject to two distributions: exponential and Weibull. Based on the assumptions and interpretations made in several previous works on such load-sharing systems, we set the mean time to failure (MTTF) of the total system as the demonstration target. We represent the MTTF as a summation of mean time between successive component failures. Next, we introduce generalized test statistics for both the underlying distributions. Finally, RDT plans for the two types of systems are established on the basis of these test statistics. PMID:29284030

Reliability demonstration test for load-sharing systems with exponential and Weibull components.

PubMed

Xu, Jianyu; Hu, Qingpei; Yu, Dan; Xie, Min

2017-01-01

Conducting a Reliability Demonstration Test (RDT) is a crucial step in production. Products are tested under certain schemes to demonstrate whether their reliability indices reach pre-specified thresholds. Test schemes for RDT have been studied in different situations, e.g., lifetime testing, degradation testing and accelerated testing. Systems designed with several structures are also investigated in many RDT plans. Despite the availability of a range of test plans for different systems, RDT planning for load-sharing systems hasn't yet received the attention it deserves. In this paper, we propose a demonstration method for two specific types of load-sharing systems with components subject to two distributions: exponential and Weibull. Based on the assumptions and interpretations made in several previous works on such load-sharing systems, we set the mean time to failure (MTTF) of the total system as the demonstration target. We represent the MTTF as a summation of mean time between successive component failures. Next, we introduce generalized test statistics for both the underlying distributions. Finally, RDT plans for the two types of systems are established on the basis of these test statistics.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guo, Yi; Keller, Jonathan; Zhang, Zhiwei

The planetary load sharing characteristics of wind turbine gearboxes supported by cylindrical roller bearings (CRBs) and preloaded tapered roller bearings (TRBs) when subjected to rotor moments are compared in this work. Planetary bearing loads were measured in field-representative dynamometer tests and compared to loads predicted by finite-element models. Load sharing was significantly improved with preloaded TRBs. In pure torque conditions, the upwind planet bearing loads in the gearbox with preloaded TRBs were a maximum of 1.14 compared to 1.47 in the gearbox with CRBs. Consequently, the predicted fatigue life of the complete set of planetary bearings for the gearbox withmore » preloaded TRBs is 3.5 times greater than that of the gearbox with CRBs.« less

[Effects of the verbal loading on laterality difference in visual field (author's transl)].

PubMed

Kawai, M

1980-02-01

In connection with the Kinsbourne's attention-model, the relation between the level of hemisphere sharing of loading task and the visual-laterality difference was examined under verbal loading conditions. The subjects were 13 (8 male and 5 female) right-handed college students. The loading tasks in Exp. I were the "same-different" judgment of Japanese hiragana alphabets and of triliteral hiragana words, and "true-false" judgment of short statements. In Exp. II, a procedure to eliminate configurational matching of the letters was followed. The results of the two experiments suggest that the visual-laterality effect occurs only when the level of hemisphere sharing of the loading task exceeds a certain lower bound.

Elastomeric load sharing device

NASA Technical Reports Server (NTRS)

Isabelle, Charles J. (Inventor); Kish, Jules G. (Inventor); Stone, Robert A. (Inventor)

1992-01-01

An elastomeric load sharing device, interposed in combination between a driven gear and a central drive shaft to facilitate balanced torque distribution in split power transmission systems, includes a cylindrical elastomeric bearing and a plurality of elastomeric bearing pads. The elastomeric bearing and bearing pads comprise one or more layers, each layer including an elastomer having a metal backing strip secured thereto. The elastomeric bearing is configured to have a high radial stiffness and a low torsional stiffness and is operative to radially center the driven gear and to minimize torque transfer through the elastomeric bearing. The bearing pads are configured to have a low radial and torsional stiffness and a high axial stiffness and are operative to compressively transmit torque from the driven gear to the drive shaft. The elastomeric load sharing device has spring rates that compensate for mechanical deviations in the gear train assembly to provide balanced torque distribution between complementary load paths of split power transmission systems.

Experimental Study of Split-Path Transmission Load Sharing

NASA Technical Reports Server (NTRS)

Krantz, Timothy L.; Delgado, Irebert R.

1996-01-01

Split-path transmissions are promising, attractive alternatives to the common planetary transmissions for helicopters. The split-path design offers two parallel paths for transmitting torque from the engine to the rotor. Ideally, the transmitted torque is shared equally between the two load paths; however, because of manufacturing tolerances, the design must be sized to allow for other than equal load sharing. To study the effect of tolerances, experiments were conducted using the NASA split-path test gearbox. Two gearboxes, nominally identical except for manufacturing tolerances, were tested. The clocking angle was considered to be a design parameter and used to adjust the load sharing of an otherwise fixed design. The torque carried in each path was measured for a matrix of input torques and clocking angles. The data were used to determine the optimal value and a tolerance for the clocking angles such that the most heavily loaded split path carried no greater than 53 percent of an input shaft torque of 367 N-m. The range of clocking angles satisfying this condition was -0.0012 +/- 0.0007 rad for box 1 and -0.0023 +/- 0.0009 rad for box 2. This study indicates that split-path gearboxes can be used successfully in rotorcraft and can be manufactured with existing technology.

A Load-Sharing Rip-Stop Fixation Construct for Arthroscopic Rotator Cuff Repair

PubMed Central

Denard, Patrick J.; Burkhart, Stephen S.

2012-01-01

Despite advancements in arthroscopic rotator cuff repair techniques, achieving tendon-to-bone healing can be difficult in the setting of poor-quality tendon. Moreover, medial tendon tears or tears with lateral tendon loss may preclude standard techniques. Rip-stop suture configurations have been shown to improve load to failure compared with simple or mattress stitch patterns and may be particularly valuable in these settings. The purpose of this report is to describe a technical modification of a rip-stop rotator cuff repair that combines the advantages of a rip-stop suture (by providing resistance to tissue cutout) and a double row of load-sharing suture anchors (minimizing the load per anchor and therefore the load per suture within each anchor). PMID:23766972

Understanding the Effects of Databases as Cognitive Tools in a Problem-Based Multimedia Learning Environment

ERIC Educational Resources Information Center

Li, Rui; Liu, Min

2007-01-01

The purpose of this study is to examine the potential of using computer databases as cognitive tools to share learners' cognitive load and facilitate learning in a multimedia problem-based learning (PBL) environment designed for sixth graders. Two research questions were: (a) can the computer database tool share sixth-graders' cognitive load? and…

Acid loading test (pH)

MedlinePlus

... medlineplus.gov/ency/article/003615.htm Acid loading test (pH) To use the sharing features on this page, please enable JavaScript. The acid loading test (pH) measures the ability of the kidneys to send ...

In vitro evaluation of stiffness and load sharing in a two-level corpectomy: comparison of static and dynamic cervical plates.

PubMed

Fogel, Guy R; Li, Zhenyu; Liu, Weiqiang; Liao, Zhenhua; Wu, Jia; Zhou, Wenyu

2010-05-01

Anterior cervical plating has been accepted in corpectomy and fusion of the cervical spine. Constrained plates were criticized for stress shielding that may lead to subsidence and pseudarthrosis. A dynamic plate allows load sharing as the graft subsides. Ideally, the dynamic plate design should maintain adequate stiffness of the construct while providing a reasonable load sharing with the strut graft. The purpose of the study was to compare dynamic and static plate kinematics with graft subsidence. The study designed was an in vitro biomechanical study in a porcine cervical spine model. Twelve spines were initially tested in intact condition with 20-N axial load in 15 degrees of flexion and extension range of motion (ROM). Then, a two-level corpectomy was created in all specimens with spines randomized to receive either a static or dynamic plate. The spines were retested under identical conditions with optimal length and undersized graft. Range of motion and graft loading were analyzed with a one-way analysis of variance (p<.05). Both plates significantly limited ROM compared with the intact spine in both graft length conditions. In extension graft, load was significantly higher (p=.001) in the static plate with optimal length, and in flexion, there was a significant loss of graft load (p=.0004). In flexion, the dynamic plate with undersized graft demonstrated significantly more load sustained (p=.0004). Both plates reasonably limited the ROM of the corpectomy. The static plate had significantly higher graft loads in extension and significant loss of graft load in flexion, whereas the dynamic plate maintained a reasonable graft load in ROM even when graft contact was imperfect. Copyright 2010 Elsevier Inc. All rights reserved.

El-Niño/Southern Oscillation (ENSO) influences on monthly NO 3 load and concentration, stream flow and precipitation in the Little River Watershed, Tifton, Georgia (GA)

NASA Astrophysics Data System (ADS)

Keener, V. W.; Feyereisen, G. W.; Lall, U.; Jones, J. W.; Bosch, D. D.; Lowrance, R.

2010-02-01

SummaryAs climate variability increases, it is becoming increasingly critical to find predictable patterns that can still be identified despite overall uncertainty. The El-Niño/Southern Oscillation is the best known pattern. Its global effects on weather, hydrology, ecology and human health have been well documented. Climate variability manifested through ENSO has strong effects in the southeast United States, seen in precipitation and stream flow data. However, climate variability may also affect water quality in nutrient concentrations and loads, and have impacts on ecosystems, health, and food availability in the southeast. In this research, we establish a teleconnection between ENSO and the Little River Watershed (LRW), GA., as seen in a shared 3-7 year mode of variability for precipitation, stream flow, and nutrient load time series. Univariate wavelet analysis of the NINO 3.4 index of sea surface temperature (SST) and of precipitation, stream flow, NO 3 concentration and load time series from the watershed was used to identify common signals. Shared 3-7 year modes of variability were seen in all variables, most strongly in precipitation, stream flow and nutrient load in strong El Niño years. The significance of shared 3-7 year periodicity over red noise with 95% confidence in SST and precipitation, stream flow, and NO 3 load time series was confirmed through cross-wavelet and wavelet-coherence transforms, in which common high power and co-variance were computed for each set of data. The strongest 3-7 year shared power was seen in SST and stream flow data, while the strongest co-variance was seen in SST and NO 3 load data. The strongest cross-correlation was seen as a positive value between the NINO 3.4 and NO 3 load with a three-month lag. The teleconnection seen in the LRW between the NINO 3.4 index and precipitation, stream flow, and NO 3 load can be utilized in a model to predict monthly nutrient loads based on short-term climate variability, facilitating management in high risk seasons.

Fluctuating Pressure Environments and Hydrodynamic Radial Force Mitigation for a Two Blade Unshrouded Inducer

NASA Technical Reports Server (NTRS)

Mulder, Andrew; Skelley, Stephen

2011-01-01

Fluctuating pressure data from water flow testing of an unshrouded two blade inducer revealed a cavitation induced oscillation with the potential to induce a radial load on the turbopump shaft in addition to other more traditionally analyzed radial loads. Subsequent water flow testing of the inducer with a rotating force measurement system confirmed that the cavitation induced oscillation did impart a radial load to the inducer. After quantifying the load in a baseline configuration, two inducer shroud treatments were selected and tested to reduce the cavitation induced load. The first treatment was to increase the tip clearance, and the second was to introduce a circumferential groove near the inducer leading edge. Increasing the clearance resulted in a small load decrease along with some steady performance degradation. The groove greatly reduced the hydrodynamic load with little to no steady performance loss. The groove did however generate some new, relatively high frequency, spatially complex oscillations to the environment.

Fluctuating Pressure Environments and Hydrodynamic Radial Force Mitigation for a Two Blade Unshrouded Inducer

NASA Technical Reports Server (NTRS)

Mulder, Andrew; Skelley, Stephen

2011-01-01

Fluctuating pressure data from water flow testing of an unshrouded two blade inducer revealed a cavitation induced oscillation with the potential to induce a radial load on the turbopump shaft in addition to other more traditionally analyzed radial loads. Subsequent water flow testing of the inducer with a rotating force measurement system confirmed that the cavitation induced oscillation did impart a radial load to the inducer. After quantifying the load in a baseline configuration, two inducer shroud treatments were selected and tested to reduce the cavitation induced load. The first treatment was to increase the tip clearance, and the second was to introduce a circumferential groove near the inducer leading edge. Increasing the clearance resulted in a small decrease in radial load along with some steady performance degradation. The groove greatly reduced the hydrodynamic load with little to no steady performance loss. The groove did however generate some new, relatively high frequency, spatially complex oscillations to the flow environment.

A 10 bit 200 MS/s pipeline ADC using loading-balanced architecture in 0.18 μm CMOS

NASA Astrophysics Data System (ADS)

Wang, Linfeng; Meng, Qiao; Zhi, Hao; Li, Fei

2017-07-01

A new loading-balanced architecture for high speed and low power consumption pipeline analog-to-digital converter (ADC) is presented in this paper. The proposed ADC uses SHA-less, op-amp and capacitor-sharing technique, capacitor-scaling scheme to reduce the die area and power consumption. A new capacitor-sharing scheme was proposed to cancel the extra reset phase of the feedback capacitors. The non-standard inter-stage gain increases the feedback factor of the first stage and makes it equal to the second stage, by which, the load capacitor of op-amp shared by the first and second stages is balanced. As for the fourth stage, the capacitor and op-amp no longer scale down. From the system’s point of view, all load capacitors of the shared OTAs are balanced by employing a loading-balanced architecture. The die area and power consumption are optimized maximally. The ADC is implemented in a 0.18 μm 1P6M CMOS technology, and occupies a die area of 1.2 × 1.2 mm{}2. The measurement results show a 55.58 dB signal-to-noise-and-distortion ratio (SNDR) and 62.97 dB spurious-free dynamic range (SFDR) with a 25 MHz input operating at a 200 MS/s sampling rate. The proposed ADC consumes 115 mW at 200 MS/s from a 1.8 V supply.

Heuristic approaches for energy-efficient shared restoration in WDM networks

NASA Astrophysics Data System (ADS)

Alilou, Shahab

In recent years, there has been ongoing research on the design of energy-efficient Wavelength Division Multiplexing (WDM) networks. The explosive growth of Internet traffic has led to increased power consumption of network components. Network survivability has also been a relevant research topic, as it plays a crucial role in assuring continuity of service with no disruption, regardless of network component failure. Network survivability mechanisms tend to utilize considerable resources such as spare capacity in order to protect and restore information. This thesis investigates techniques for reducing energy demand and enhancing energy efficiency in the context of network survivability. We propose two novel heuristic energy-efficient shared protection approaches for WDM networks. These approaches intend to save energy by setting on sleep mode devices that are not being used while providing shared backup paths to satisfy network survivability. The first approach exploits properties of a math series in order to assign weight to the network links. It aims at reducing power consumption at the network indirectly by aggregating traffic on a set of nodes and links with high traffic load level. Routing traffic on links and nodes that are already under utilization makes it possible for the links and nodes with no load to be set on sleep mode. The second approach is intended to dynamically route traffic through nodes and links with high traffic load level. Similar to the first approach, this approach computes a pair of paths for every newly arrived demand. It computes these paths for every new demand by comparing the power consumption of nodes and links in the network before the demand arrives with their potential power consumption if they are chosen along the paths of this demand. Simulations of two different networks were used to compare the total network power consumption obtained using the proposed techniques against a standard shared-path restoration scheme. Shared-path restoration is a network survivability method in which a link-disjoint backup path and wavelength is reserved at the time of call setup for a working path. However, in order to reduce spare capacity consumption, this reserved backup path and wavelength may be shared with other backup paths. Pool Sharing Scheme (PSS) is employed to implement shared-path restoration scheme [1]. In an optical network, the failure of a single link leads to the failure of all the lightpaths that pass through that particular link. PSS ensures that the amount of backup bandwidth required on a link to restore the failed connections will not be more than the total amount of reserved backup bandwidth on that link. Simulation results indicate that the proposed approaches lead to up to 35% power savings in WDM networks when traffic load is low. However, power saving decreases to 14% at high traffic load level. Furthermore, in terms of the total capacity consumption for working paths, PSS outperforms the two proposed approaches, as expected. In terms of total capacity consumption all the approaches behave similarly. In general, at low traffic load level, the two proposed approaches behave similar to PSS in terms of average link load, and the ratio of block demands. Nevertheless, at high traffic load, the proposed approaches result in higher ratio of blocked demands than PSS. They also lead to higher average link load than PSS for the equal number of generated demands.

Biomechanics of Far Cortical Locking

PubMed Central

Bottlang, Michael; Feist, Florian

2011-01-01

The development of FCL was motivated by a conundrum: locked plating constructs provide inherently rigid stabilization, yet they should facilitate biological fixation and secondary bone healing that relies on flexible fixation to stimulate callus formation. Recent studies have confirmed that the high stiffness of standard locked plating constructs can suppress interfragmentary motion to a level that is insufficient to reliably promote secondary fracture healing by callus formation. Furthermore, rigid locking screws cause an uneven stress distribution that may lead to stress fracture at the end screw and stress shielding under the plate. This review summarizes four key features of FCL constructs that have shown to enhance fixation and fracture healing: Flexible fixation, load distribution, progressive stiffening, and parallel interfragmentary motion. Specifically, flexible fixation provided by FCL reduces the stiffness of a locked plating construct by 80–88% to actively promote callus proliferation similar to an external fixator. Load distribution is evenly shared between FCL screws to mitigate stress risers at the end screw. Progressive stiffening occurs by near cortex support of FCL screws and provides additional support under elevated loading. Finally, parallel interfragmentary motion by s-shaped flexion of FCL screws has shown to induce symmetric callus formation. In combination, these features of FCL constructs have shown to induce more callus and to yield significantly stronger and more consistent healing compared to standard locked plating constructs. As such, FCL constructs function as true internal fixators by replicating the biomechanical behavior and biological healing response of external fixators. PMID:21248556

Prehension synergies: A study of digit force adjustments to the continuously varied load force exerted on a partially constrained hand-held object

PubMed Central

Friedman, Jason; Latash, Mark L.; Zatsiorsky, Vladimir M.

2009-01-01

We examined how the digit forces adjust when a load force acting on a hand-held object continuously varies. The subjects were required to hold the handle still while a linearly increasing and then decreasing force was applied to the handle. The handle was constrained, such that it could only move up and down, and rotate about a horizontal axis. In addition the moment arm of the thumb tangential force was 1.5 times the moment arm of the virtual finger (VF, an imagined finger with the mechanical action equal to that of the four fingers) force. Unlike the situation when there are equal moment arms, the experimental setup forced the subjects to choose between (a) sharing equally the increase in load force between the thumb and virtual finger but generating a moment of tangential force, which had to be compensated by negatively covarying the moment due to normal forces, or (b) sharing unequally the load force increase between the thumb and VF but preventing generation of a moment of tangential forces. We found that different subjects tended to use one of these two strategies. These findings suggest that the selection by the CNS of prehension synergies at the VF-thumb level with respect to the moment of force are non-obligatory and reflect individual subject preferences. This unequal sharing of the load by the tangential forces, in contrast to the previously observed equal sharing, suggests that the invariant feature of prehension may be a correlated increase in tangential forces rather than an equal increase. PMID:19554319

Peer Norms and Sharing of Injection Paraphernalia among Puerto Rican Injection Drug Users in New York and Puerto Rico

ERIC Educational Resources Information Center

Andia, Jonny F.; Deren, Sherry; Robles, Rafaela R.; Kang, Sung-Yeon; Colon, Hector M.

2008-01-01

This study examines the influence of peer norms on sharing of injection paraphernalia (e.g., indirect sharing behaviors, including sharing of cookers, cotton, rinse water and back/front loading) among Puerto Rican injection drug users (IDUs) in Bayamon, Puerto Rico, and East Harlem, New York City. Data were collected from 873 Puerto Rican IDUs…

Load Sharing in Anti-Air Warfare Coordination: Criteria and a Simulation Test Plan

DTIC Science & Technology

1991-09-01

NAVAL POSTGRADUATE SCHOOL Monterey, California AD-A245 968 DTIG EB 18 199Z THESIS L LOAD SHARING IN ANTI-AIR WARFARE COORDINATION: CRITERIA AND A...REPORT NUMBER(S) Ga. NAME OF PERFORMING ORGANIZATION Gb. OFFICE SYMBOL 71. NAME OF MONITORING ORGANIZATION Naval Postgraduate School OR 6c. ADDRESS...the degree of MASTER OF SCIENCE IN OPERATIONS RESEARCH from the NAVAL POSTGRADUATE SCHOOL September 1991 Au thor: ’ysviL-’ / ; d Stephen Hue Keley

Analysis and performance of paralleling circuits for modular inverter-converter systems

NASA Technical Reports Server (NTRS)

Birchenough, A. G.; Gourash, F.

1972-01-01

As part of a modular inverter-converter development program, control techniques were developed to provide load sharing among paralleled inverters or converters. An analysis of the requirements of paralleling circuits and a discussion of the circuits developed and their performance are included in this report. The current sharing was within 5.6 percent of rated-load current for the ac modules and 7.4 percent for the dc modules for an initial output voltage unbalance of 5 volts.

Measurements of near-ultimate strength for multiwalled carbon nanotubes and irradiation-induced crosslinking improvements.

PubMed

Peng, Bei; Locascio, Mark; Zapol, Peter; Li, Shuyou; Mielke, Steven L; Schatz, George C; Espinosa, Horacio D

2008-10-01

The excellent mechanical properties of carbon nanotubes are being exploited in a growing number of applications from ballistic armour to nanoelectronics. However, measurements of these properties have not achieved the values predicted by theory due to a combination of artifacts introduced during sample preparation and inadequate measurements. Here we report multiwalled carbon nanotubes with a mean fracture strength >100 GPa, which exceeds earlier observations by a factor of approximately three. These results are in excellent agreement with quantum-mechanical estimates for nanotubes containing only an occasional vacancy defect, and are approximately 80% of the values expected for defect-free tubes. This performance is made possible by omitting chemical treatments from the sample preparation process, thus avoiding the formation of defects. High-resolution imaging was used to directly determine the number of fractured shells and the chirality of the outer shell. Electron irradiation at 200 keV for 10, 100 and 1,800 s led to improvements in the maximum sustainable loads by factors of 2.4, 7.9 and 11.6 compared with non-irradiated samples of similar diameter. This effect is attributed to crosslinking between the shells. Computer simulations also illustrate the effects of various irradiation-induced crosslinking defects on load sharing between the shells.

Measurements of near-ultimate strength for multiwalled carbon nanotubes and irradiation-induced crosslinking improvements.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peng, B.; Locascio, M.; Zapol, P.

2008-01-01

The excellent mechanical properties of carbon nanotubes are being exploited in a growing number of applications from ballistic armour to nanoelectronics. However, measurements of these properties have not achieved the values predicted by theory due to a combination of artifacts introduced during sample preparation and inadequate measurements. Here we report multiwalled carbon nanotubes with a mean fracture strength >100 GPa, which exceeds earlier observations by a factor of approximately three. These results are in excellent agreement with quantum-mechanical estimates for nanotubes containing only an occasional vacancy defect, and are {approx}80% of the values expected for defect-free tubes. This performance ismore » made possible by omitting chemical treatments from the sample preparation process, thus avoiding the formation of defects. High-resolution imaging was used to directly determine the number of fractured shells and the chirality of the outer shell. Electron irradiation at 200 keV for 10, 100 and 1,800 s led to improvements in the maximum sustainable loads by factors of 2.4, 7.9 and 11.6 compared with non-irradiated samples of similar diameter. This effect is attributed to crosslinking between the shells. Computer simulations also illustrate the effects of various irradiation-induced crosslinking defects on load sharing between the shells.« less

H2-M polymorphism in mice susceptible to collagen-induced arthritis involves the peptide binding groove

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walter, W.; Loos, M.; Maeurer, M.J.

1996-12-31

The ability to develop type II collagen (CII)-induced arthritis (CIA) in mice is associated with the major histocompatibility I-A gene and with as yet poorly defined regulatory molecules of the major histocompatibility complex (MHC) class II antigen processing and presentation pathway. H2-M molecules are thought to be involved in the loading of antigenic peptides into the MHC class II binding cleft. We sequenced H2-Ma, H2-Mb1, and H2-Mb2 genes from CIA-susceptible and -resistant mouse strains and identified four different Ma and Mb2 alleles, and three different Mb1 alleles defined by polymorphic residues within the predicted peptide binding groove. Most CIA-resistant mousemore » strains share common Ma, Mb1, and Mb2 alleles. In contrast, H2-M alleles designated Ma-III, Ma-IV, Mb1-III, and Mb2-IV could be exclusively identified in the CIA-susceptible H2{sup r} and H2{sup q} haplotypes, suggesting that allelic H2-M molecules may modulate the composition of different CII peptides loaded onto MHC class II molecules, presumably presenting {open_quotes}arthritogenic{close_quotes} epitopes to T lymphocytes. 42 refs., 4 figs., 3 tabs.« less

Does Education Lower Allostatic Load? A Co-twin Control Study

PubMed Central

Hamdi, Nayla R.; South, Susan C.; Krueger, Robert F.

2016-01-01

Many studies have found that education is associated with better health, but the causal basis of this association is unclear. The current study used a co-twin control design to examine if differences in years of education within twin pairs predict allostatic load. The strength of this design is that it controls for genetic and other familial confounds shared between twins. The sample consisted of 381 twins (with 292 twins from 146 complete pairs; mean age=57; 61% female) who participated in the biomarker project of the Midlife Development in the United States (MIDUS) study. Individual-level analyses showed a significant, negative association between years of education and allostatic load, but this association was explained entirely by familial influences shared between twins. The results of this study suggest that schooling does not itself protect against allostatic load. PMID:26778778

Specimen-specific modeling of hip fracture pattern and repair.

PubMed

Ali, Azhar A; Cristofolini, Luca; Schileo, Enrico; Hu, Haixiang; Taddei, Fulvia; Kim, Raymond H; Rullkoetter, Paul J; Laz, Peter J

2014-01-22

Hip fracture remains a major health problem for the elderly. Clinical studies have assessed fracture risk based on bone quality in the aging population and cadaveric testing has quantified bone strength and fracture loads. Prior modeling has primarily focused on quantifying the strain distribution in bone as an indicator of fracture risk. Recent advances in the extended finite element method (XFEM) enable prediction of the initiation and propagation of cracks without requiring a priori knowledge of the crack path. Accordingly, the objectives of this study were to predict femoral fracture in specimen-specific models using the XFEM approach, to perform one-to-one comparisons of predicted and in vitro fracture patterns, and to develop a framework to assess the mechanics and load transfer in the fractured femur when it is repaired with an osteosynthesis implant. Five specimen-specific femur models were developed from in vitro experiments under a simulated stance loading condition. Predicted fracture patterns closely matched the in vitro patterns; however, predictions of fracture load differed by approximately 50% due to sensitivity to local material properties. Specimen-specific intertrochanteric fractures were induced by subjecting the femur models to a sideways fall and repaired with a contemporary implant. Under a post-surgical stance loading, model-predicted load sharing between the implant and bone across the fracture surface varied from 59%:41% to 89%:11%, underscoring the importance of considering anatomic and fracture variability in the evaluation of implants. XFEM modeling shows potential as a macro-level analysis enabling fracture investigations of clinical cohorts, including at-risk groups, and the design of robust implants. © 2013 Published by Elsevier Ltd.

Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor α and disuse

PubMed Central

Zaman, Gul; Saxon, Leanne K.; Sunters, Andrew; Hilton, Helen; Underhill, Peter; Williams, Debbie; Price, Joanna S.; Lanyon, Lance E.

2010-01-01

Loading-related changes in gene expression in resident cells in the tibia of female mice in the contexts of normality (WT), estrogen deficiency (WT-OVX), absence of estrogen receptor α (ERα−/−) and disuse due to sciatic neurectomy (WT-SN) were established by microarray. Total RNA was extracted from loaded and contra-lateral non-loaded tibiae at selected time points after a single, short period of dynamic loading sufficient to engender an osteogenic response. There were marked changes in the expression of many genes according to context as well as in response to loading within those contexts. In WT mice at 3, 8, 12 and 24 h after loading the expression of 642, 341, 171 and 24 genes, respectively, were differentially regulated compared with contra-lateral bones which were not loaded. Only a few of the genes differentially regulated by loading in the tibiae of WT mice have recognized roles in bone metabolism or have been linked previously to osteogenesis (Opn, Sost, Esr1, Tgfb1, Lrp1, Ostn, Timp, Mmp, Ctgf, Postn and Irs1, BMP and DLX5). The canonical pathways showing the greatest loading-related regulation were those involving pyruvate metabolism, mitochondrial dysfunction, calcium-induced apoptosis, glycolysis/gluconeogenesis, aryl hydrocarbon receptor and oxidative phosphorylation. In the tibiae from WT-OVX, ERα−/− and WT-SN mice, 440, 439 and 987 genes respectively were differentially regulated by context alone compared to WT. The early response to loading in tibiae of WT-OVX mice involved differential regulation compared to their contra-lateral non-loaded pair of fewer genes than in WT, more down-regulation than up-regulation and a later response. This was shared by WT-SN. In tibiae of ERα−/− mice, the number of genes differentially regulated by loading was markedly reduced at all time points. These data indicate that in resident bone cells, both basal and loading-related gene expression is substantially modified by context. Many of the genes differentially regulated by the earliest loading-related response were primarily involved in energy metabolism and were not specific to bone. PMID:19857613

Grip force and force sharing in two different manipulation tasks with bottles.

PubMed

Cepriá-Bernal, Javier; Pérez-González, Antonio; Mora, Marta C; Sancho-Bru, Joaquín L

2017-07-01

Grip force and force sharing during two activities of daily living were analysed experimentally in 10 right-handed subjects. Four different bottles, filled to two different levels, were manipulated for two tasks: transporting and pouring. Each test subject's hand was instrumented with eight thin wearable force sensors. The grip force and force sharing were significantly different for each bottle model. Increasing the filling level resulted in an increase in grip force, but the ratio of grip force to load force was higher for lighter loads. The task influenced the force sharing but not the mean grip force. The contributions of the thumb and ring finger were higher in the pouring task, whereas the contributions of the palm and the index finger were higher in the transport task. Mean force sharing among fingers was 30% for index, 29% for middle, 22% for ring and 19% for little finger. Practitioner Summary: We analysed grip force and force sharing in two manipulation tasks with bottles: transporting and pouring. The objective was to understand the effects of the bottle features, filling level and task on the contribution of different areas of the hand to the grip force. Force sharing was different for each task and the bottles features affected to both grip force and force sharing.

Planetary Load Sharing in Three-Point- Mounted Wind Turbine Gearboxes: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guo, Yi; Keller, Jonathan A

Wind turbine gearboxes do not achieve their expected design life. The cost of gearbox replacements and rebuilds and the downtime associated with these failures increase the cost of wind energy. In 2007, the U.S. Department of Energy established the National Renewable Energy Laboratory (NREL) Gearbox Reliability Collaborative (GRC). Its goals are to understand the root causes of premature gearbox failures and improve their reliability. To date, the GRC has focused on a 750-kW drivetrain with a three-stage, three-point-mounted gearbox. A nonproprietary version of the gearbox containing CRBs with C3 clearances in the planetary stage was customized. Two of these gearboxes,more » GB1 and GB2, were manufactured and then tested in the National Wind Technology Center's 2.5-MW dynamometer and in the field. Major GRC findings include the detrimental effect of rotor moments on planetary load sharing and predicted fatigue, and the risk of bearing sliding in low-torque conditions for three-point configuration drivetrains. Based on the knowledge gained from testing and analysis of the original design, the GRC gearbox was redesigned to improve its load-sharing characteristics and predicted fatigue. This new gearbox is named GB3. As shown in Figure 1, its key improvement is the incorporation of preloaded TRBs that support the planet carrier and planets. Roller loads can be optimized and bearing life maximized with a small preload [4]. These preloaded bearings, along with interference-fitted planet pins, improve alignments and load-sharing characteristics. A semi-integrated planet bearing design also increases capacity and eliminates outer race fretting. Romax Technology, with Powertrain Engineers and the Timken Company (Timken), completed the redesign. Timken manufactured and instrumented the planet gears and bearings. Brad Foote Gearing manufactured the other gearing and assembled the gearbox.« less

Working memory costs of task switching.

PubMed

Liefooghe, Baptist; Barrouillet, Pierre; Vandierendonck, André; Camos, Valérie

2008-05-01

Although many accounts of task switching emphasize the importance of working memory as a substantial source of the switch cost, there is a lack of evidence demonstrating that task switching actually places additional demands on working memory. The present study addressed this issue by implementing task switching in continuous complex span tasks with strictly controlled time parameters. A series of 4 experiments demonstrate that recall performance decreased as a function of the number of task switches and that the concurrent load of item maintenance had no influence on task switching. These results indicate that task switching induces a cost on working memory functioning. Implications for theories of task switching, working memory, and resource sharing are addressed.

A procedure for combining acoustically induced and mechanically induced loads (first passage failure design criterion)

NASA Technical Reports Server (NTRS)

Crowe, D. R.; Henricks, W.

1983-01-01

The combined load statistics are developed by taking the acoustically induced load to be a random population, assumed to be stationary. Each element of this ensemble of acoustically induced loads is assumed to have the same power spectral density (PSD), obtained previously from a random response analysis employing the given acoustic field in the STS cargo bay as a stationary random excitation. The mechanically induced load is treated as either (1) a known deterministic transient, or (2) a nonstationary random variable of known first and second statistical moments which vary with time. A method is then shown for determining the probability that the combined load would, at any time, have a value equal to or less than a certain level. Having obtained a statistical representation of how the acoustic and mechanical loads are expected to combine, an analytical approximation for defining design levels for these loads is presented using the First Passage failure criterion.

Time-dependent fiber bundles with local load sharing.

PubMed

Newman, W I; Phoenix, S L

2001-02-01

Fiber bundle models, where fibers have random lifetimes depending on their load histories, are useful tools in explaining time-dependent failure in heterogeneous materials. Such models shed light on diverse phenomena such as fatigue in structural materials and earthquakes in geophysical settings. Various asymptotic and approximate theories have been developed for bundles with various geometries and fiber load-sharing mechanisms, but numerical verification has been hampered by severe computational demands in larger bundles. To gain insight at large size scales, interest has returned to idealized fiber bundle models in 1D. Such simplified models typically assume either equal load sharing (ELS) among survivors, or local load sharing (LLS) where a failed fiber redistributes its load onto its two nearest flanking survivors. Such models can often be solved exactly or asymptotically in increasing bundle size, N, yet still capture the essence of failure in real materials. The present work focuses on 1D bundles under LLS. As in previous works, a fiber has failure rate following a power law in its load level with breakdown exponent rho. Surviving fibers under fixed loads have remaining lifetimes that are independent and exponentially distributed. We develop both new asymptotic theories and new computational algorithms that greatly increase the bundle sizes that can be treated in large replications (e.g., one million fibers in thousands of realizations). In particular we develop an algorithm that adapts several concepts and methods that are well-known among computer scientists, but relatively unknown among physicists, to dramatically increase the computational speed with no attendant loss of accuracy. We consider various regimes of rho that yield drastically different behavior as N increases. For 1/2< or =rho< or =1, ELS and LLS have remarkably similar behavior (they have identical lifetime distributions at rho=1) with approximate Gaussian bundle lifetime statistics and a finite limiting mean. For rho>1 this Gaussian behavior also applies to ELS, whereas LLS behavior diverges sharply showing brittle, weakest volume behavior in terms of characteristic elements derived from critical cluster formation. For 0

Biomechanical and biological aspects of defect treatment in fractures using helical plates.

PubMed

Perren, S M; Regazzoni, P; Fernandez, A A D

2014-01-01

The clinical case of figure 1 through figure 11 shows a series of impressive failures of plate fixation. The plates were repeatedly applied bridging a comminuted bone segment in a heavy patient. The biomechanical analysis elaborates why this happened and proposes an unconventional procedure to prevent this failure with a minimally invasive procedure. A plate bridging an open gap or a defect in a long bone diaphysis is exposed to full functional load. According to clinical observations such plate application often fails even without external load such as weight bearing. The plate risks to break through fatigue when exposed during a long time to cyclic loading. This type of failure has been observed even with broad plates as well in femoral as in tibiae. The first option to avoid such failure consists in protecting the plate by installing load sharing between plate and either bone or an additional implant. This reduces the load carried by the plate to a safe level. Load sharing with bone may be installed at surgery by establishing solid mechanical bridge between the two main fragments of the fractured bone. The optimal load sharing relies on a solid compressed contact between the main fragments. It can be established because the bone is able to take a large load which results in optimal protection of the plate. In the case of an extended comminuted bone segment it may be very difficult, traumatizing and inefficient to reconstruct the bone. In the present case it was impossible to establish load sharing through the bone. The second option protecting the plate is provided by callus bridging of the gap or defect. The formation of a solid callus bridge takes time but the fatigue failure of the plate also takes time. Therefore, the callus bridge may prevent a late fatigue failure. The surgeon may select one of several options: - Replacing the lack of bone support using a second plate which immediately alleviates plate loading. The drawback of application of a second conventional plate is the extent of surgical trauma at the critical site of healing. - Shingling and/or applying an autologous cancellous bone graft: This procedure provides initially no relevant load sharing but will do so after a couple of weeks. The mechanical coupling of the comparably soft graft and the main fracture fragments presents little problems. Applying a cortical bone graft: Such a graft does provide initial only small load sharing and does a less good job inducing callus than a cancellous graft. Furthermore, the coupling by callus between a somewhat rigid bone graft and the mobile main fracture fragments requires a solid maintained contact. If the cortical graft is fixed using implants with small contact area to the graft such as screws or cerclage loops, the local stress may be critical and the graft may break. When the cortical graft is fixed with cerclage wires the procedure must take into account the limited strength of the individual cerclage. Therefore multiple and well-spaced cerclages are required and may lead to success especially if an intramedullary component of the implant contributes to protection (6). The degree of unloading depends apparently on the stiffness of the material of the protecting splint. Though, more important is the effect of the dimensions of the splint. While titanium as a material is about 50% less stiff than steel, the thickness of the implant changes the stiffness with the third power. That is doubling the thickness results in eightfold increased stiffness. When considering the unloading by application of a second plate the leverage of the second plate plays an important role. The larger the distance between the axis of bending and the second implant the larger the protecting effect. The helical plate (2, 3, 7) as introduced by A.A.D. Fernandez offers biological and mechanical advantages. It can be applied without touching the fracture site maintaining the critical biology intact and provides mechanically efficient unloading. Its application is fairly simple: The helical plate is modified conventional long and small plate that is twisted between its ends about 90 degrees. The twist is applied using "bending irons" (4, 5, 8) whereby the force required is small and the exact degree of twist is not critical. Therefore the twist is applicable operating bending irons by hand. Assuming a situation where a plate bridging a defect or non-union has failed the broken plate is replaced by a similar implant: At the distal end of the bone fracture and opposite to the surgical approach a small incision allows to slide in the helical plate in such a way that proximally the plate ends on the same side of the limb as the replaced plate. Ideally the two plate ends meet and the application of the helical plate does not ask for an additional surgical exposure at this location. Otherwise a small minimally invasive exposure is required. The helical plate is then fixed to the main bone fragments using a couple of locked screws. The following case demonstrates the use and efficiency of the helical plate saving a situation where multiple attempts using conventional plates had failed. The successful final treatment of this case was performed by A. A. D. Fernandez.

Influence of inclination angles on intra- and inter-limb load-sharing during uphill walking.

PubMed

Hong, Shih-Wun; Leu, Tsai-Hsueh; Li, Jia-Da; Wang, Ting-Ming; Ho, Wei-Ping; Lu, Tung-Wu

2014-01-01

Uphill walking is an inevitable part of daily living, placing more challenges on the locomotor system with greater risk of falls than level walking does. The current study aimed to investigate the effects of inclination angles on the inter-joint and inter-limb load-sharing during uphill walking in terms of total support moment and contributions of individual joint moments to the total support moment. Fifteen young adults walked up walkways with 0°, 5°, 10° and 15° of slope while kinematic and kinetic data were collected and analyzed. With increasing inclination angles, the first peak of the total support moment was increased with unaltered individual joint contributions, suggesting an unaltered inter-joint control pattern in the leading limb to meet the increased demands. The second peak of the total support moment remained unchanged with increasing inclination angles primarily through a compensatory redistribution of the hip and knee moments. During DLS, the leading limb shared the majority of the whole body support moments. The current results reveal basic intra- and inter-limb load-sharing patterns of uphill walking, which will be helpful for a better understanding of the control strategies adopted and for subsequent clinical applications. Copyright © 2013 Elsevier B.V. All rights reserved.

Inattentional Deafness: Visual Load Leads to Time-Specific Suppression of Auditory Evoked Responses

PubMed Central

Molloy, Katharine; Griffiths, Timothy D.; Lavie, Nilli

2015-01-01

Due to capacity limits on perception, conditions of high perceptual load lead to reduced processing of unattended stimuli (Lavie et al., 2014). Accumulating work demonstrates the effects of visual perceptual load on visual cortex responses, but the effects on auditory processing remain poorly understood. Here we establish the neural mechanisms underlying “inattentional deafness”—the failure to perceive auditory stimuli under high visual perceptual load. Participants performed a visual search task of low (target dissimilar to nontarget items) or high (target similar to nontarget items) load. On a random subset (50%) of trials, irrelevant tones were presented concurrently with the visual stimuli. Brain activity was recorded with magnetoencephalography, and time-locked responses to the visual search array and to the incidental presence of unattended tones were assessed. High, compared to low, perceptual load led to increased early visual evoked responses (within 100 ms from onset). This was accompanied by reduced early (∼100 ms from tone onset) auditory evoked activity in superior temporal sulcus and posterior middle temporal gyrus. A later suppression of the P3 “awareness” response to the tones was also observed under high load. A behavioral experiment revealed reduced tone detection sensitivity under high visual load, indicating that the reduction in neural responses was indeed associated with reduced awareness of the sounds. These findings support a neural account of shared audiovisual resources, which, when depleted under load, leads to failures of sensory perception and awareness. SIGNIFICANCE STATEMENT The present work clarifies the neural underpinning of inattentional deafness under high visual load. The findings of near-simultaneous load effects on both visual and auditory evoked responses suggest shared audiovisual processing capacity. Temporary depletion of shared capacity in perceptually demanding visual tasks leads to a momentary reduction in sensory processing of auditory stimuli, resulting in inattentional deafness. The dynamic “push–pull” pattern of load effects on visual and auditory processing furthers our understanding of both the neural mechanisms of attention and of cross-modal effects across visual and auditory processing. These results also offer an explanation for many previous failures to find cross-modal effects in experiments where the visual load effects may not have coincided directly with auditory sensory processing. PMID:26658858

Analysis of DMFC/battery hybrid power system for portable applications

NASA Astrophysics Data System (ADS)

Lee, Bong-Do; Jung, Doo-Hwan; Ko, Young-Ho

This study was carried out to develop a direct methanol fuel cell (DMFC)/battery hybrid power system used in portable applications. For a portable power system, the DMFC was applied for the main power source at average load and the battery was applied for auxiliary power at overload. Load share characteristics of hybrid power source were analyzed by computational simulation. The connection apparatus between the DMFC and the battery was set and investigated in the real system. Voltages and currents of the load, the battery and the DMFC were measured according to fuel, air and load changes. The relationship between load share characteristic and battery capacity was surveyed. The relationship was also studied in abnormal operation. A DMFC stack was manufactured for this experiment. For the study of the connection characteristics to the fuel cell Pb-acid, Ni-Cd and Ni-MH batteries were tested. The results of this study can be applied to design the interface module of the fuel cell/battery hybrid system and to determine the design requirement in the fuel cell stack for portable applications.

The Senate Electoral Cycle and Bicameral Appropriations Politics1

PubMed Central

Shepsle, Kenneth A.; Van Houweling, Robert P.; Abrams, Samuel J.; Hanson, Peter C.

2009-01-01

We consider the consequences of the Senate electoral cycle and bicameralism for distributive politics, introducing the concept of contested credit claiming, i.e. that members of a state’s House and Senate delegations must share the credit for appropriations that originate in their chamber with delegation members in the other chamber. Using data that isolates appropriations of each chamber, we test a model of the strategic incentives contested credit claiming creates. Our empirical analysis indicates that the Senate electoral cycle induces a back-loading of benefits to the end of senatorial terms, but that the House blunts this tendency with countercyclical appropriations. Our analysis informs our understanding of appropriations earmarking, and points a way forward in studying the larger consequences of bicameral legislatures. PMID:19543433

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cai, S.; Schaffer, J. E.; Ren, Y.

Room temperature deformation of a Ni{sub 46.7}Ti{sub 42.8}Nb{sub 10.5} alloy was studied by in-situ synchrotron X-ray diffraction. Compared to binary NiTi alloy, the Nb dissolved in the matrix significantly increased the onset stress for Stress-Induced Martensite Transformation (SIMT). The secondary phase, effectively a Nb-nanowire dispersion in a NiTi-Nb matrix, increased the elastic stiffness of the bulk material, reduced the strain anisotropy in austenite families by load sharing during SIMT, and increased the stress hysteresis by resisting reverse phase transformation during unloading. The stress hysteresis can be controlled over a wide range by heat treatment through its influences on the residualmore » stress of the Nb-nanowire dispersion and the stability of the austenite.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cai, S.; Schaffer, J. E.; Ren, Y.

Room temperature deformation of a Ni46.7Ti42.8Nb10.5 alloy was studied by in-situ synchrotron X-ray diffraction. Compared to binary NiTi alloy, the Nb dissolved in the matrix significantly increased the onset stress for Stress-Induced Martensite Transformation (SIMT). The secondary phase, effectively a Nb-nanowire dispersion in a NiTi-Nb matrix, increased the elastic stiffness of the bulk material, reduced the strain anisotropy in austenite families by loading sharing during SIMT, and increased the stress hysteresis by resisting reverse phase transformation during unloading. The stress hysteresis can be controlled over a wide range by changing the heat treatment temperature through its influences on the residualmore » stress-strain state of the Nb-nanowire dispersion.« less

Unsuccessful Treatment of Atrophic Mandible Fracture by Use of Improper Materials.

PubMed

de Moraes Ferreira, Ana Carulina Rezende; Garcia Junior, Idelmo Rangel; Silva, Adalberto Novaes; de Carvalho Reis, Erik Neiva Ribeiro; Pires, Willian Ricardo; Bonardi, João Paulo; Borba, Alexandre Meireles

2016-06-01

Fractures of atrophic mandibles are present on the day by day of buccomaxillofacial surgeons. Mandible atrophy occurs due to tooth loss, which over time induces bone resorption leading to a fragile and susceptible to fracture structure. This paper reports the case of a patient victim of face trauma resulting in atrophic mandible fracture with treatment failure through the use of shared load miniplate. Therefore, a new treatment was performed with miniplate of system 2.4 along with bone graft. After 6 months, the patient was rehabilitated with implant-supported prosthesis installation. It is concluded that for successful treatment of atrophic mandible fractures, the use of rigid plates is necessary, allowing an excellent rehabilitation of the stomatognathic system.

Role of subchondral bone properties and changes in development of load-induced osteoarthritis in mice.

PubMed

Adebayo, O O; Ko, F C; Wan, P T; Goldring, S R; Goldring, M B; Wright, T M; van der Meulen, M C H

2017-12-01

Animal models recapitulating post-traumatic osteoarthritis (OA) suggest that subchondral bone (SCB) properties and remodeling may play major roles in disease initiation and progression. Thus, we investigated the role of SCB properties and its effects on load-induced OA progression by applying a tibial loading model on two distinct mouse strains treated with alendronate (ALN). Cyclic compression was applied to the left tibia of 26-week-old male C57Bl/6 (B6, low bone mass) and FVB (high bone mass) mice. Mice were treated with ALN (26 μg/kg/day) or vehicle (VEH) for loading durations of 1, 2, or 6 weeks. Changes in articular cartilage and subchondral and epiphyseal cancellous bone were analyzed using histology and microcomputed tomography. FVB mice exhibited thicker cartilage, a thicker SCB plate, and higher epiphyseal cancellous bone mass and tissue mineral density than B6 mice. Loading induced cartilage pathology, osteophyte formation, and SCB changes; however, lower initial SCB mass and stiffness in B6 mice did not attenuate load-induced OA severity compared to FVB mice. By contrast, FVB mice exhibited less cartilage damage, and slower-growing and less mature osteophytes. In B6 mice, inhibiting bone remodeling via ALN treatment exacerbated cartilage pathology after 6 weeks of loading, while in FVB mice, inhibiting bone remodeling protected limbs from load-induced cartilage loss. Intrinsically lower SCB properties were not associated with attenuated load-induced cartilage loss. However, inhibiting bone remodeling produced differential patterns of OA pathology in animals with low compared to high SCB properties, indicating that these factors do influence load-induced OA progression. Copyright © 2017 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

Mechanics of collective unfolding

NASA Astrophysics Data System (ADS)

Caruel, M.; Allain, J.-M.; Truskinovsky, L.

2015-03-01

Mechanically induced unfolding of passive crosslinkers is a fundamental biological phenomenon encountered across the scales from individual macro-molecules to cytoskeletal actin networks. In this paper we study a conceptual model of athermal load-induced unfolding and use a minimalistic setting allowing one to emphasize the role of long-range interactions while maintaining full analytical transparency. Our model can be viewed as a description of a parallel bundle of N bistable units confined between two shared rigid backbones that are loaded through a series spring. We show that the ground states in this model correspond to synchronized, single phase configurations where all individual units are either folded or unfolded. We then study the fine structure of the wiggly energy landscape along the reaction coordinate linking the two coherent states and describing the optimal mechanism of cooperative unfolding. Quite remarkably, our study shows the fundamental difference in the size and the structure of the folding-unfolding energy barriers in the hard (fixed displacements) and soft (fixed forces) loading devices which persists in the continuum limit. We argue that both, the synchronization and the non-equivalence of the mechanical responses in hard and soft devices, have their origin in the dominance of long-range interactions. We then apply our minimal model to skeletal muscles where the power-stroke in acto-myosin crossbridges can be interpreted as passive folding. A quantitative analysis of the muscle model shows that the relative rigidity of myosin backbone provides the long-range interaction mechanism allowing the system to effectively synchronize the power-stroke in individual crossbridges even in the presence of thermal fluctuations. In view of the prototypical nature of the proposed model, our general conclusions pertain to a variety of other biological systems where elastic interactions are mediated by effective backbones.

Detecting local haplotype sharing and haplotype association

USDA-ARS?s Scientific Manuscript database

A novel haplotype association method is presented, and its power is demonstrated. Relying on a statistical model for linkage disequilibrium (LD), the method first infers ancestral haplotypes and their loadings at each marker for each individual. The loadings are then used to quantify local haplotype...

Automatic load sharing in inverter modules

NASA Technical Reports Server (NTRS)

Nagano, S.

1979-01-01

Active feedback loads transistor equally with little power loss. Circuit is suitable for balancing modular inverters in spacecraft, computer power supplies, solar-electric power generators, and electric vehicles. Current-balancing circuit senses differences between collector current for power transistor and average value of load currents for all power transistors. Principle is effective not only in fixed duty-cycle inverters but also in converters operating at variable duty cycles.

Lipid nano-bubble combined with ultrasound for anti-keloids therapy.

PubMed

Wang, Xiao Qing; Li, Zhou-Na; Wang, Qi-Ming; Jin, Hong-Yan; Gao, Zhonggao; Jin, Zhe-Hu

2018-03-01

Keloids were characterized by excessive growth of fibrous tissues, and shared several pathological characteristics with cancer. They did put physical and emotional stress on patients in that keloids could badly change appearance of patients. N-(4-hydroxyphenyl) retinamide (4HPR) showed cytotoxic activity on a wide variety of invasive-growth cells. Our work was aim to prepare N-(4-hydroxyphenyl) retinamide-loaded lipid microbubbles (4HPR-LM) combined with ultrasound for anti-keloid therapy. 4HPR-loaded liposomes (4HPR-L) were first prepared by film evaporation method, and then 4HPR-LM were manufactured by mixing 4HPR-L and perfluoropentane (PFP) with ultrasonic cavitation method. The mean particle size and entrapment efficiency 4HPR-LM were 113 nm and 95%, respectively. The anti-keloids activity of 4HPR-LM was assessed with BALB/c nude mice bearing subcutaneous xenograft keloids model. 4HPR-LM, combined with ultrasound, could significantly induce apoptosis of keloid fibroblasts in vitro and inhibited growth of keloids in vivo. Thus, 4HPR-LM could be considered as a promising agent for anti-keloids therapy.

Assessing Knowledge Sharing Among Academics: A Validation of the Knowledge Sharing Behavior Scale (KSBS).

PubMed

Ramayah, T; Yeap, Jasmine A L; Ignatius, Joshua

2014-04-01

There is a belief that academics tend to hold on tightly to their knowledge and intellectual resources. However, not much effort has been put into the creation of a valid and reliable instrument to measure knowledge sharing behavior among the academics. To apply and validate the Knowledge Sharing Behavior Scale (KSBS) as a measure of knowledge sharing behavior within the academic community. Respondents (N = 447) were academics from arts and science streams in 10 local, public universities in Malaysia. Data were collected using the 28-item KSBS that assessed four dimensions of knowledge sharing behavior namely written contributions, organizational communications, personal interactions, and communities of practice. The exploratory factor analysis showed that the items loaded on the dimension constructs that they were supposed to represent, thus proving construct validity. A within-factor analysis revealed that each set of items representing their intended dimension loaded on only one construct, therefore establishing convergent validity. All four dimensions were not perfectly correlated with each other or organizational citizenship behavior, thereby proving discriminant validity. However, all four dimensions correlated with organizational commitment, thus confirming predictive validity. Furthermore, all four factors correlated with both tacit and explicit sharing, which confirmed their concurrent validity. All measures also possessed sufficient reliability (α > .70). The KSBS is a valid and reliable instrument that can be used to formally assess the types of knowledge artifacts residing among academics and the degree of knowledge sharing in relation to those artifacts. © The Author(s) 2014.

Planetary gear profile modification design based on load sharing modelling

NASA Astrophysics Data System (ADS)

Iglesias, Miguel; Fernández Del Rincón, Alfonso; De-Juan, Ana Magdalena; Garcia, Pablo; Diez, Alberto; Viadero, Fernando

2015-07-01

In order to satisfy the increasing demand on high performance planetary transmissions, an important line of research is focused on the understanding of some of the underlying phenomena involved in this mechanical system. Through the development of models capable of reproduce the system behavior, research in this area contributes to improve gear transmission insight, helping developing better maintenance practices and more efficient design processes. A planetary gear model used for the design of profile modifications ratio based on the levelling of the load sharing ratio is presented. The gear profile geometry definition, following a vectorial approach that mimics the real cutting process of gears, is thoroughly described. Teeth undercutting and hypotrochoid definition are implicitly considered, and a procedure for the incorporation of a rounding arc at the tooth tip in order to deal with corner contacts is described. A procedure for the modeling of profile deviations is presented, which can be used for the introduction of both manufacturing errors and designed profile modifications. An easy and flexible implementation of the profile deviation within the planetary model is accomplished based on the geometric overlapping. The contact force calculation and dynamic implementation used in the model are also introduced, and parameters from a real transmission for agricultural applications are presented for the application example. A set of reliefs is designed based on the levelling of the load sharing ratio for the example transmission, and finally some other important dynamic factors of the transmission are analyzed to assess the changes in the dynamic behavior with respect to the non-modified case. Thus, the main innovative aspect of the proposed planetary transmission model is the capacity of providing a simulated load sharing ratio which serves as design variable for the calculation of the tooth profile modifications.

SAHAYOG: A Testbed for Load Sharing under Failure,

DTIC Science & Technology

1987-07-01

messages, shared memory and semaphores . To communicate using messages, processes create message queues using system-provided prim- itives. The message...The size of the memory that is to be shared is decided by the process when it makes a request for memory allocation. The semaphore option of IPC can be...used to prevent two or more concurrent processes from executing their critical sections at the same time. Semaphores must be used when the processes

Time and Cognitive Load in Working Memory

ERIC Educational Resources Information Center

Barrouillet, Pierre; Bernardin, Sophie; Portrat, Sophie; Vergauwe, Evie; Camos, Valerie

2007-01-01

According to the time-based resource-sharing model (P. Barrouillet, S. Bernardin, & V. Camos, 2004), the cognitive load a given task involves is a function of the proportion of time during which it captures attention, thus impeding other attention-demanding processes. Accordingly, the present study demonstrates that the disruptive effect on…

Taking Attention Away from the Auditory Modality: Context-dependent Effects on Early Sensory Encoding of Speech.

PubMed

Xie, Zilong; Reetzke, Rachel; Chandrasekaran, Bharath

2018-05-24

Increasing visual perceptual load can reduce pre-attentive auditory cortical activity to sounds, a reflection of the limited and shared attentional resources for sensory processing across modalities. Here, we demonstrate that modulating visual perceptual load can impact the early sensory encoding of speech sounds, and that the impact of visual load is highly dependent on the predictability of the incoming speech stream. Participants (n = 20, 9 females) performed a visual search task of high (target similar to distractors) and low (target dissimilar to distractors) perceptual load, while early auditory electrophysiological responses were recorded to native speech sounds. Speech sounds were presented either in a 'repetitive context', or a less predictable 'variable context'. Independent of auditory stimulus context, pre-attentive auditory cortical activity was reduced during high visual load, relative to low visual load. We applied a data-driven machine learning approach to decode speech sounds from the early auditory electrophysiological responses. Decoding performance was found to be poorer under conditions of high (relative to low) visual load, when the incoming acoustic stream was predictable. When the auditory stimulus context was less predictable, decoding performance was substantially greater for the high (relative to low) visual load conditions. Our results provide support for shared attentional resources between visual and auditory modalities that substantially influence the early sensory encoding of speech signals in a context-dependent manner. Copyright © 2018 IBRO. Published by Elsevier Ltd. All rights reserved.

Prediction of contact path and load sharing in spiral bevel gears

NASA Technical Reports Server (NTRS)

Bibel, George D.; Tiku, Karuna; Kumar, Ashok

1994-01-01

A procedure is presented to perform a contact analysis of spiral bevel gears in order to predict the contact path and the load sharing as the gears roll through mesh. The approach utilizes recent advances in automated contact methods for nonlinear finite element analysis. A sector of the pinion and gear is modeled consisting of three pinion teeth and four gear teeth in mesh. Calculation of the contact force and stresses through the gear meshing cycle are demonstrated. Summary of the results are presented using three dimensional plots and tables. Issues relating to solution convergence and requirements for running large finite element analysis on a supercomputer are discussed.

Vent modification of large ribbon parachutes to enhance cluster performance

NASA Technical Reports Server (NTRS)

Kolega, D. J.; Woodis, W. R.; Reuter, J. D.

1986-01-01

Due to uneven load sharing and lagging inflation rates, the design of the Large Main Parachute (LMP) cluster, used to recover the Space Shuttle steel case Solid Rocket Boosters, had to be modified. The cause of the problem was excessive variation in effective porosity in the crown area of the LMP during first stage inflation. The design modification consisted of adding horizontal ribbons above the existing vent band to reduce the vent porosity and better control the position and attitude of the vent lines. Performance of modified LMP's since introduction indicates that the load sharing between the clustered chutes has been significantly improved.

Revisiting control establishments for emerging energy hubs

NASA Astrophysics Data System (ADS)

Nasirian, Vahidreza

Emerging small-scale energy systems, i.e., microgrids and smartgrids, rely on centralized controllers for voltage regulation, load sharing, and economic dispatch. However, the central controller is a single-point-of-failure in such a design as either the controller or attached communication links failure can render the entire system inoperable. This work seeks for alternative distributed control structures to improve system reliability and help to the scalability of the system. A cooperative distributed controller is proposed that uses a noise-resilient voltage estimator and handles global voltage regulation and load sharing across a DC microgrid. Distributed adaptive droop control is also investigated as an alternative solution. A droop-free distributed control is offered to handle voltage/frequency regulation and load sharing in AC systems. This solution does not require frequency measurement and, thus, features a fast frequency regulation. Distributed economic dispatch is also studied, where a distributed protocol is designed that controls generation units to merge their incremental costs into a consensus and, thus, push the entire system to generate with the minimum cost. Experimental verifications and Hardware-in-the-Loop (HIL) simulations are used to study efficacy of the proposed control protocols.

Bacterial vaginosis-associated microflora isolated from the female genital tract activates HIV-1 expression.

PubMed

Al-Harthi, L; Roebuck, K A; Olinger, G G; Landay, A; Sha, B E; Hashemi, F B; Spear, G T

1999-07-01

Alteration of cervicovaginal microbial flora can lead to vaginosis, which is associated with an increased risk of HIV-1 transmission. We recently characterized a soluble HIV-inducing factor (HIF) from the cervicovaginal lavage (CVL) samples of women. The goals of this study were to determine the effect of cervicovaginal microflora on HIV-1 expression and to elucidate the relationship between HIF activity and microflora. Physiologically relevant microorganisms, Mycoplasma, diphtheroid-like bacteria, Gardnerella vaginalis, Streptococcus agalactiae, and Streptococcus constellatus, cultured from the CVL of a representative woman with a clinical condition of bacterial vaginosis and possessing HIF activity, induced HIV-1 expression. The magnitude of virus induction varied widely with the greatest stimulation induced by diphtheroid-like bacteria and Mycoplasma. The transcriptional induction by Mycoplasma was mediated by activation of the KB enhancer, an activation mechanism shared with HIF. Also as with HIF, Mycoplasma induced AP-1 dependent transcription. Polymerase chain reaction (PCR)-based speciation showed that the isolate was M. hominis. Our data indicate that bacterial vaginosis-associated microflora can enhance HIV-1 transcription and replication and identify M. hominis as a potential source for HIF activity. The virus-enhancing activities associated with the microflora and HIF may increase genital tract viral load, potentially contributing to HIV transmission.

Characterizing output bottlenecks in a supercomputer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xie, Bing; Chase, Jeffrey; Dillow, David A

2012-01-01

Supercomputer I/O loads are often dominated by writes. HPC (High Performance Computing) file systems are designed to absorb these bursty outputs at high bandwidth through massive parallelism. However, the delivered write bandwidth often falls well below the peak. This paper characterizes the data absorption behavior of a center-wide shared Lustre parallel file system on the Jaguar supercomputer. We use a statistical methodology to address the challenges of accurately measuring a shared machine under production load and to obtain the distribution of bandwidth across samples of compute nodes, storage targets, and time intervals. We observe and quantify limitations from competing traffic,more » contention on storage servers and I/O routers, concurrency limitations in the client compute node operating systems, and the impact of variance (stragglers) on coupled output such as striping. We then examine the implications of our results for application performance and the design of I/O middleware systems on shared supercomputers.« less

A time-shared machine repair problem with mixed spares under N-policy

NASA Astrophysics Data System (ADS)

Jain, Madhu; Shekhar, Chandra; Shukla, Shalini

2016-06-01

The present investigation deals with a machine repair problem consisting of cold and warm standby machines. The machines are subject to breakdown and are repaired by the permanent repairman operating under N-policy. There is provision of one additional removable repairman who is called upon when the work load of failed machines crosses a certain threshold level and is removed as soon as the work load again ceases to that level. Both repairmen recover the failed machines by following the time sharing concept which means that the repairmen share their repair job simultaneously among all the failed machines that have joined the system for repair. Markovian model has been developed by considering the queue dependent rates and solved analytically using the recursive technique. Various performance indices are derived which are further used to obtain the cost function. By taking illustration, numerical simulation and sensitivity analysis have been provided.

Instructors as Investors: A Collegial Conspiracy To Improve Classroom Instruction.

ERIC Educational Resources Information Center

Lawson, Joan Kenny

Due to heavy teaching loads, high adjunct faculty numbers, and scheduling and commuting factors, community college faculty infrequently have the opportunity to share in a collegial forum. In an attempt to provide an opportunity for faculty to share innovative instructional strategies and discuss their work, Hudson Valley Community College (HVCC),…

Parasite Load Induces Progressive Spleen Architecture Breakage and Impairs Cytokine mRNA Expression in Leishmania infantum-Naturally Infected Dogs

PubMed Central

Cavalcanti, Amanda S.; Ribeiro-Alves, Marcelo; Pereira, Luiza de O. R.; Mestre, Gustavo Leandro; Ferreira, Anna Beatriz Robottom; Morgado, Fernanda N.; Boité, Mariana C.; Cupolillo, Elisa; Moraes, Milton O.; Porrozzi, Renato

2015-01-01

Canine Visceral Leishmaniasis (CVL) shares many aspects with the human disease and dogs are considered the main urban reservoir of L. infantum in zoonotic VL. Infected dogs develop progressive disease with a large clinical spectrum. A complex balance between the parasite and the genetic/immunological background of the host are decisive for infection evolution and clinical outcome. This study comprised 92 Leishmania infected mongrel dogs of various ages from Mato Grosso, Brazil. Spleen samples were collected for determining parasite load, humoral response, cytokine mRNA expression and histopathology alterations. By real-time PCR for the ssrRNA Leishmania gene, two groups were defined; a low (lowP, n = 46) and a high parasite load groups (highP, n = 42). When comparing these groups, results show variable individual humoral immune response with higher specific IgG production in infected animals but with a notable difference in CVL rapid test optical densities (DPP) between highP and lowP groups. Splenic architecture disruption was characterized by disorganization of white pulp, more evident in animals with high parasitism. All cytokine transcripts in spleen were less expressed in highP than lowP groups with a large heterogeneous variation in response. Individual correlation analysis between cytokine expression and parasite load revealed a negative correlation for both pro-inflammatory cytokines: IFNγ, IL-12, IL-6; and anti-inflammatory cytokines: IL-10 and TGFβ. TNF showed the best negative correlation (r2 = 0.231; p<0.001). Herein we describe impairment on mRNA cytokine expression in leishmania infected dogs with high parasite load associated with a structural modification in the splenic lymphoid micro-architecture. We also discuss the possible mechanism responsible for the uncontrolled parasite growth and clinical outcome. PMID:25875101

Distributed control system for parallel-connected DC boost converters

DOEpatents

Goldsmith, Steven

2017-08-15

The disclosed invention is a distributed control system for operating a DC bus fed by disparate DC power sources that service a known or unknown load. The voltage sources vary in v-i characteristics and have time-varying, maximum supply capacities. Each source is connected to the bus via a boost converter, which may have different dynamic characteristics and power transfer capacities, but are controlled through PWM. The invention tracks the time-varying power sources and apportions their power contribution while maintaining the DC bus voltage within the specifications. A central digital controller solves the steady-state system for the optimal duty cycle settings that achieve a desired power supply apportionment scheme for a known or predictable DC load. A distributed networked control system is derived from the central system that utilizes communications among controllers to compute a shared estimate of the unknown time-varying load through shared bus current measurements and bus voltage measurements.

Conditional load and store in a shared memory

DOEpatents

Blumrich, Matthias A; Ohmacht, Martin

2015-02-03

A method, system and computer program product for implementing load-reserve and store-conditional instructions in a multi-processor computing system. The computing system includes a multitude of processor units and a shared memory cache, and each of the processor units has access to the memory cache. In one embodiment, the method comprises providing the memory cache with a series of reservation registers, and storing in these registers addresses reserved in the memory cache for the processor units as a result of issuing load-reserve requests. In this embodiment, when one of the processor units makes a request to store data in the memory cache using a store-conditional request, the reservation registers are checked to determine if an address in the memory cache is reserved for that processor unit. If an address in the memory cache is reserved for that processor, the data are stored at this address.

Successful short-segment instrumentation and fusion for thoracolumbar spine fractures: a consecutive 41/2-year series.

PubMed

Parker, J W; Lane, J R; Karaikovic, E E; Gaines, R W

2000-05-01

A retrospective review of all the surgically managed spinal fractures at the University of Missouri Medical Center during the 41/2-year period from January 1989 to July 1993 was performed. Of the 51 surgically managed patients, 46 were instrumented by short-segment technique (attachment of one level above the fracture to one level below the fracture). The other 5 patients in this consecutive series had multiple trauma. These patients were included in the review because this was a consecutive series. However, they were grouped separately because they were instrumented by long-segment technique because of their multiple organ system injuries. The choice of the anterior or posterior approach for short-segment instrumentation was based on the Load-Sharing Classification published in a 1994 issue of Spine. The purpose of this review was to demonstrate that grading comminution by use of the Load-Sharing Classification for approach selection and the choice of patients with isolated fractures who are cooperative with spinal bracing for 4 months provide the keys to successful short-segment treatment of isolated spinal fractures. The current literature implies that the use of pedicle screws for short-segment instrumentation of spinal fracture is dangerous and inappropriate because of the high screw fracture rate. Charts, operative notes, preoperative and postoperative radiographs, computed tomography scans, and follow-up records of all patients were reviewed carefully from the time of surgery until final follow-up assessment. The Load-Sharing Classification had been used prospectively for all patients before their surgery to determine the approach for short-segment instrumentation. Denis' Pain Scale and Work Scales were obtained during follow-up evaluation for all patients. All patients were observed over 40 months except for 1 patient who died of unrelated causes after 35 months. The mean follow-up period was 66 months (51/2 years). No patient was lost to follow-up evaluation. Prospective application of the Load-Sharing Classification to the patients' injury and restriction of the short-segment approach to cooperative patients with isolated spinal fractures (excluding multisystem trauma patients) allowed 45 of 46 patients instrumented by the short-segment technique to proceed to successful healing in virtual anatomic alignment. The Load-Sharing Classification is a straightforward way to describe the amount of bony comminution in a spinal fracture. When applied to patients with isolated spine fractures who are cooperative with 3 to 4 months of spinal bracing, it can help the surgeon select short-segment pedicle-screw-based fixation using the posterior approach for less comminuted injuries and the anterior approach for those more comminuted. The choice of which fracture-dislocations should be strut grafted anteriorly and which need only posterior short-segment pedicle-screw-based instrumentation also can be made using the Load-Sharing Classification.

Indentation studies on Y[sub 2]O[sub 3]-stabilized ZrO[sub 2]; 1: Development of indentation-induced cracks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kaliszewski, M.S.; Behrens, G.; Heuer, A.H.

1994-05-01

The development of Vickers indent-induced cracks with increasing indent load has been studied in two Y[sub 2]O[sub 3]-stabilized ZrO[sub 2] ceramics. Such cracks form as radial or Palmqvist cracks at low loads, assume kidney'' shapes at intermediate loads, and finally form median (half-penny) cracks at high loads. The plastic zone directly beneath the indent is uncracked; a significant portion of the plasticity induced by indentation occurs by martensitic transformation.

Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus.

PubMed

Alonso-Perez, Elisa; Suarez-Gestal, Marian; Calaza, Manuel; Blanco, Francisco J; Suarez, Ana; Santos, Maria Jose; Papasteriades, Chryssa; Carreira, Patricia; Pullmann, Rudolf; Ordi-Ros, Josep; Marchini, Maurizio; Skopouli, Fotini N; Bijl, Marc; Barrizone, Nadia; Sebastiani, Gian Domenico; Migliaresi, Sergio; Witte, Torsten; Lauwerys, Bernard R; Kovacs, Attila; Ruzickova, Sarka; Gomez-Reino, Juan J; Gonzalez, Antonio

2014-06-19

We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was interpreted as indicating that men require more genetic susceptibility than women to develop SLE. Nineteen SLE-associated loci (thirteen of which are shared with the previous study) were analyzed in 1,457 SLE patients and 1,728 healthy controls of European ancestry. Genetic risk load was calculated as sex-specific sum genetic risk scores (GRS(s)). Our results did not replicate those of the previous study at either the level of individual loci or the global level of GRS(s). GRS(s) were larger in women than in men (4.20 ± 1.07 in women vs. 3.27 ± 0.98 in men). This very significant difference (P < 10(-16)) was more dependent on the six new loci not included in the previous study (59% of the difference) than on the thirteen loci that are shared (the remaining 41%). However, the 13 shared loci also showed a higher genetic risk load in women than in men in our study (P = 6.6 × 10(-7)), suggesting that heterogeneity of participants, in addition to different loci, contributed to the opposite results. Our results show the lack of a clear trend toward higher genetic risk in one of the sexes for the analyzed SLE loci. They also highlight several limitations of assessments of genetic risk load, including the possibility of ascertainment bias with loci discovered in studies that have included mainly women.

Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus

PubMed Central

2014-01-01

Introduction We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was interpreted as indicating that men require more genetic susceptibility than women to develop SLE. Methods Nineteen SLE-associated loci (thirteen of which are shared with the previous study) were analyzed in 1,457 SLE patients and 1,728 healthy controls of European ancestry. Genetic risk load was calculated as sex-specific sum genetic risk scores (GRSs). Results Our results did not replicate those of the previous study at either the level of individual loci or the global level of GRSs. GRSs were larger in women than in men (4.20 ± 1.07 in women vs. 3.27 ± 0.98 in men). This very significant difference (P < 10−16) was more dependent on the six new loci not included in the previous study (59% of the difference) than on the thirteen loci that are shared (the remaining 41%). However, the 13 shared loci also showed a higher genetic risk load in women than in men in our study (P = 6.6 × 10−7), suggesting that heterogeneity of participants, in addition to different loci, contributed to the opposite results. Conclusion Our results show the lack of a clear trend toward higher genetic risk in one of the sexes for the analyzed SLE loci. They also highlight several limitations of assessments of genetic risk load, including the possibility of ascertainment bias with loci discovered in studies that have included mainly women. PMID:24946689

Extreme prices in electricity balancing markets from an approach of statistical physics

NASA Astrophysics Data System (ADS)

Mureddu, Mario; Meyer-Ortmanns, Hildegard

2018-01-01

An increase in energy production from renewable energy sources is viewed as a crucial achievement in most industrialized countries. The higher variability of power production via renewables leads to a rise in ancillary service costs over the power system, in particular costs within the electricity balancing markets, mainly due to an increased number of extreme price spikes. This study analyzes the impact of an increased share of renewable energy sources on the behavior of price and volumes of the Italian balancing market. Starting from configurations of load and power production, which guarantee a stable performance, we implement fluctuations in the load and in renewables; in particular we artificially increase the contribution of renewables as compared to conventional power sources to cover the total load. We then determine the amount of requested energy in the balancing market and its fluctuations, which are induced by production and consumption. Within an approach of agent-based modeling we estimate the resulting energy prices and costs. While their average values turn out to be only slightly affected by an increased contribution from renewables, the probability for extreme price events is shown to increase along with undesired peaks in the costs. Our methodology provides a tool for estimating outliers in prices obtained in the energy balancing market, once data of consumption, production and their typical fluctuations are provided.

Is the destabilisation of lake peipsi ecosystem caused by increased phosphorus loading or decreased nitrogen loading?

PubMed

Nõges, T; Laugaste, R; Loigu, E; Nedogarko, I; Skakalski, B; Nõges, P

2005-01-01

Lake Peipsi (3555 km2, mean depth 7.1 m) located on the border of Estonia and Russia is the largest transboundary lake in Europe. L. Peipsi consists of three parts. The shared largest northern part L. Peipsi s.s. (2611 km2, 8.3 m) and the southern L. Pihkva (708 km2, 3.8 m) which belongs mainly to Russia are connected by the river-shaped L. Lämmijärv (236 km2, 2.5 m). The catchment area (44,245 km2 without lake area) is shared between Estonia (33.3%), Russia (58.6%) and Latvia (8%). Intensive eutrophication of L. Peipsi started in the 1970s. The biomass of N2-fixing cyanobacteria was low at heavy nutrient loading in the 1980s. After the collapse of soviet-type agriculture in the early 1990s, the loading of nitrogen sharply decreased. A certain improvement of L. Peipsi s.s. was noticed at the beginning of the 1990s together with the temporary reduction of phosphorus loading from Estonian catchment while in recent years a destabilisation of the ecosystem has been observed. This deterioration has been expressed mainly as intensive blue-green blooms and fish-kills in summer. Reappearance of blooms has been explained by the decrease in N/P loading ratio due to reduced N discharge while in some periods increased phosphorus loading could have supported this trend.

Self-aligning hydraulic piston assembly for tensile testing of ceramic

DOEpatents

Liu, Kenneth C.

1987-01-01

The present invention is directed to a self-aligning grip housing assembly that can transmit an uniaxial load to a tensil specimen without introducing bending stresses into the specimen. Disposed inside said grip housing assembly are a multiplicity of supporting pistons connected to a common source of pressurized oil that carry equal shares of the load applied to the specimen irregardless whether there is initial misalignment between the specimen load column assembly and housing axis.

Self-aligning hydraulic piston assembly for tensile testing of ceramic

DOEpatents

Liu, K.C.

1987-08-18

The present invention is directed to a self-aligning grip housing assembly that can transmit an uniaxial load to a tensile specimen without introducing bending stresses into the specimen. Disposed inside said grip housing assembly are a multiplicity of supporting pistons connected to a common source of pressurized oil that carry equal shares of the load applied to the specimen regardless whether there is initial misalignment between the specimen load column assembly and housing axis. 4 figs.

Sharing the Load: Understanding the Roles of Academics and Host Supervisors in Work-Integrated Learning

ERIC Educational Resources Information Center

Winchester-Seeto, Theresa; Rowe, Anna; Mackaway, Jacqueline

2016-01-01

Student supervision is a key factor underpinning the success of work-integrated learning programs. Supervisory responsibilities can be shared across a number of stakeholders including university staff and host/workplace supervisors. While there have been attempts to understand the roles played by each of these stakeholders, little research has…

Dynamic Transfers Of Tasks Among Computers

NASA Technical Reports Server (NTRS)

Liu, Howard T.; Silvester, John A.

1989-01-01

Allocation scheme gives jobs to idle computers. Ideal resource-sharing algorithm should have following characteristics: Dynamics, decentralized, and heterogeneous. Proposed enhanced receiver-initiated dynamic algorithm (ERIDA) for resource sharing fulfills all above criteria. Provides method balancing workload among hosts, resulting in improvement in response time and throughput performance of total system. Adjusts dynamically to traffic load of each station.

Wake-Induced Aerodynamics on a Trailing Aircraft

NASA Technical Reports Server (NTRS)

Mendenhall, Michael R.; Lesieutre, Daniel J.; Kelly, Michael J.

2016-01-01

NASA conducted flight tests to measure the exhaust products from alternative fuels using a DC-8 transport aircraft and a Falcon business jet. An independent analysis of the maximum vortex-induced loads on the Falcon in the DC-8 wake was conducted for pre-flight safety analysis and to define safe trail distances for the flight tests. Static and dynamic vortex-induced aerodynamic loads on the Falcon were predicted at a matrix of locations aft of the DC-8 under flight-test conditions, and the maximum loads were compared with design limit loads to assess aircraft safety. Trajectory simulations for the Falcon during close encounters with the DC-8 wake were made to study the vortex-induced loads during traverses of the DC-8 primary trailing vortex. A parametric study of flight traverses through the trailing vortex was conducted to assess Falcon flight behavior and motion characteristics.

Nutrient loads within the Sava River Catchment and comparison with load relations in the Baltic region

NASA Astrophysics Data System (ADS)

Levi, Lea; Cvetkovic, Vladimir; Destouni, Georgia

2015-04-01

This study compiles estimates of total nitrogen and phosphorus loads in the Sava River Catchment (SRC), investigates the load relations to human drivers of excess nutrient loading, and compares them with corresponding relations implied by data reported for the Baltic region. Nutrient load data, associated average discharge concentrations (ratio of load to water discharge) and their relations to human drivers are investigated across subcatchments of the SRC with different agricultural and population conditions. The Zagreb subcatchment, which has the smallest area but the highest population density and runoff among the investigated SRC subcatchments, exhibits the highest loads of both nitrogen and phosphorus. Overall for the SRC, results show high correlation (R2=0.93-0.95) of nutrient loads with population density and of concentrations with farmland share. A further question investigated here is then to what degree these relations are comparable with such relations found also for the Baltic region. The two regions are otherwise quite different in their climatic, agricultural and wastewater treatment conditions, so relation consistency, even if surprising, would be important in indicating some degree of relation transferability worthy of further investigation also in other regions. For the Baltic region corresponding correlations to those found in the SRC are in the range R2=0.79-0.88. In particular nitrogen and phosphorus concentration correlations with farmland share are qualitatively consistent between the regions. At the same time, phosphorus concentration correlation with population density shows quite different results between regions. Obtained results indicate a certain level of transferability of dependencies between the two regions and call for further detailed investigations on finer spatial-temporal scales.

Limits to Open Class Performance?

NASA Technical Reports Server (NTRS)

Bowers, Albion H.

2008-01-01

This presentation discusses open or unlimited class aircraft performance limitations and design solutions. Limitations in this class of aircraft include slow climbing flight which requires low wing loading, high cruise speed which requires high wing loading, gains in induced or viscous drag alone which result in only half the gain overall and other structural problems (yaw inertia and spins, flutter and static loads integrity). Design solutions include introducing minimum induced drag for a given span (elliptical span load or winglets) and introducing minimum induced drag for a bell shaped span load. It is concluded that open class performance limits (under current rules and technologies) is very close to absolute limits, though some gains remain to be made from unexplored areas and new technologies.

Android Protection Mechanism: A Signed Code Security Mechanism for Smartphone Applications

DTIC Science & Technology

2011-03-01

status registers, exceptions, endian support, unaligned access support, synchronization primitives , the Jazelle Extension, and saturated integer...supports comprehensive non-blocking shared-memory synchronization primitives that scale for multiple-processor system designs. This is an improvement... synchronization . Memory semaphores can be loaded and altered without interruption because the load and store operations are atomic. Processor

Effect of Loading History on Airway Smooth Muscle Cell-Matrix Adhesions.

PubMed

Irons, Linda; Owen, Markus R; O'Dea, Reuben D; Brook, Bindi S

2018-06-05

Integrin-mediated adhesions between airway smooth muscle (ASM) cells and the extracellular matrix (ECM) regulate how contractile forces generated within the cell are transmitted to its external environment. Environmental cues are known to influence the formation, size, and survival of cell-matrix adhesions, but it is not yet known how they are affected by dynamic fluctuations associated with tidal breathing in the intact airway. Here, we develop two closely related theoretical models to study adhesion dynamics in response to oscillatory loading of the ECM, representing the dynamic environment of ASM cells in vivo. Using a discrete stochastic-elastic model, we simulate individual integrin binding and rupture events and observe two stable regimes in which either bond formation or bond rupture dominate, depending on the amplitude of the oscillatory loading. These regimes have either a high or low fraction of persistent adhesions, which could affect the level of strain transmission between contracted ASM cells and the airway tissue. For intermediate loading, we observe a region of bistability and hysteresis due to shared loading between existing bonds; the level of adhesion depends on the loading history. These findings are replicated in a related continuum model, which we use to investigate the effect of perturbations mimicking deep inspirations (DIs). Because of the bistability, a DI applied to the high adhesion state could either induce a permanent switch to a lower adhesion state or allow a return of the system to the high adhesion state. Transitions between states are further influenced by the frequency of oscillations, cytoskeletal or ECM stiffnesses, and binding affinities, which modify the magnitudes of the stable adhesion states as well as the region of bistability. These findings could explain (in part) the transient bronchodilatory effect of a DI observed in asthmatics compared to a more sustained effect in normal subjects. Copyright © 2018 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Gravity loading induces adenosine triphosphate release and phosphorylation of extracellular signal-regulated kinases in human periodontal ligament cells.

PubMed

Ito, Mai; Arakawa, Toshiya; Okayama, Miki; Shitara, Akiko; Mizoguchi, Itaru; Takuma, Taishin

2014-11-01

The periodontal ligament (PDL) receives mechanical stress (MS) from dental occlusion or orthodontic tooth movement. Mechanical stress is thought to be a trigger for remodeling of the PDL and alveolar bone, although its signaling mechanism is still unclear. So we investigated the effect of MS on adenosine triphosphate (ATP) release and extracellular signal-regulated kinases (ERK) phosphorylation in PDL cells. Mechanical stress was applied to human PDL cells as centrifugation-mediated gravity loading. Apyrase, Ca(2+)-free medium and purinergic receptor agonists and antagonists were utilized to analyze the contribution of purinergic receptors to ERK phosphorylation. Gravity loading and ATP increased ERK phosphorylation by 5 and 2.5 times, respectively. Gravity loading induced ATP release from PDL cells by tenfold. Apyrase and suramin diminished ERK phosphorylation induced by both gravity loading and ATP. Under Ca(2+)-free conditions the phosphorylation by gravity loading was partially decreased, whereas ATP-induced phosphorylation was unaffected. Receptors P2Y4 and P2Y6 were prominently expressed in the PDL cells. Gravity loading induced ATP release and ERK phosphorylation in PDL fibroblasts, and ATP signaling via P2Y receptors was partially involved in this phosphorylation, which in turn would enhance gene expression for the remodeling of PDL tissue during orthodontic tooth movement. © 2013 Wiley Publishing Asia Pty Ltd.

Calcium-independent metal-ion catalytic mechanism of anthrax edema factor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shen, Yuequan; Zhukovskaya, Natalia L.; Guo, Qing

2009-11-18

Edema factor (EF), a key anthrax exotoxin, has an anthrax protective antigen-binding domain (PABD) and a calmodulin (CaM)-activated adenylyl cyclase domain. Here, we report the crystal structures of CaM-bound EF, revealing the architecture of EF PABD. CaM has N- and C-terminal domains and each domain can bind two calcium ions. Calcium binding induces the conformational change of CaM from closed to open. Structures of the EF-CaM complex show how EF locks the N-terminal domain of CaM into a closed conformation regardless of its calcium-loading state. This represents a mechanism of how CaM effector alters the calcium affinity of CaM andmore » uncouples the conformational change of CaM from calcium loading. Furthermore, structures of EF-CaM complexed with nucleotides show that EF uses two-metal-ion catalysis, a prevalent mechanism in DNA and RNA polymerases. A histidine (H351) further facilitates the catalysis of EF by activating a water to deprotonate 3'OH of ATP. Mammalian adenylyl cyclases share no structural similarity with EF and they also use two-metal-ion catalysis, suggesting the catalytic mechanism-driven convergent evolution of two structurally diverse adenylyl cyclases.« less

What role do hurricanes play in sediment delivery to subsiding river deltas?

USGS Publications Warehouse

Smith, James E.; Bentley, Samuel J.; Snedden, Gregg; White, Crawford

2015-01-01

The Mississippi River Delta (MRD) has undergone tremendous land loss over the past century due to natural and anthropogenic influences, a fate shared by many river deltas globally. A globally unprecedented effort to restore and sustain the remaining subaerial portions of the delta is now underway, an endeavor that is expected to cost $50–100B over the next 50 yr. Success of this effort requires a thorough understanding of natural and anthropogenic controls on sediment supply and delta geomorphology. In the MRD, hurricanes have been paradoxically identified as both substantial agents of widespread land loss, and vertical marsh sediment accretion. We present the first multi-decadal chronostratigraphic assessment of sediment supply for a major coastal basin of the MRD that assesses both fluvial and hurricane-induced contributions to sediment accumulation in deltaic wetlands. Our findings indicate that over multidecadal timescales, hurricane-induced sediment delivery may be an important contributor for deltaic wetland vertical accretion, but the contribution from hurricanes to long-term sediment accumulation is substantially less than sediment delivery supplied by existing and planned river-sediment diversions at present-day river-sediment loads.

What Role do Hurricanes Play in Sediment Delivery to Subsiding River Deltas?

NASA Astrophysics Data System (ADS)

Smith, James E.; Bentley, Samuel J.; Snedden, Gregg A.; White, Crawford

2015-12-01

The Mississippi River Delta (MRD) has undergone tremendous land loss over the past century due to natural and anthropogenic influences, a fate shared by many river deltas globally. A globally unprecedented effort to restore and sustain the remaining subaerial portions of the delta is now underway, an endeavor that is expected to cost $50-100B over the next 50 yr. Success of this effort requires a thorough understanding of natural and anthropogenic controls on sediment supply and delta geomorphology. In the MRD, hurricanes have been paradoxically identified as both substantial agents of widespread land loss, and vertical marsh sediment accretion. We present the first multi-decadal chronostratigraphic assessment of sediment supply for a major coastal basin of the MRD that assesses both fluvial and hurricane-induced contributions to sediment accumulation in deltaic wetlands. Our findings indicate that over multidecadal timescales, hurricane-induced sediment delivery may be an important contributor for deltaic wetland vertical accretion, but the contribution from hurricanes to long-term sediment accumulation is substantially less than sediment delivery supplied by existing and planned river-sediment diversions at present-day river-sediment loads.

Confinement-induced Molecular Templating and Controlled Ligation

NASA Astrophysics Data System (ADS)

Berard, Daniel; Shayegan, Marjan; Michaud, François; Henkin, Gil; Scott, Shane; Leith, Jason; Leslie, Sabrina; Leslie Lab Team

Loading and manipulating long DNA molecules within sub-50 nm cross-section nanostructures for genomic and biochemical analyses, while retaining their structural integrity, present key technological challenges to the biotechnology sector, such as device clogging and molecular breakage. We overcome these challenges by using Convex Lens-induced Confinement (CLiC) technology to gently load DNA into nanogrooves from above. Here, we demonstrate single-fluorophore visualization of custom DNA barcodes as well as efficient top-loading of DNA into sub-50 nm nanogrooves of variable topographies. We study confinement-enhanced self-ligation of polymers loaded in circular nanogrooves. Further, we use concentric, circular nanogrooves to eliminate confinement gradient-induced drift of stretched DNA.

Potential for shared log transport services

Treesearch

Tim McDonald; Steve Taylor; Jorge Valenzuela

2001-01-01

A simulation model of a log transport logistics network was developed. The model could be structured to either share truck capacity among a group of loggers, or to assign a fixed number of trucks to individual loggers. Another variation of the model allowed the use of a staging yard to set out loaded trailers and deliver them to destinations using dedicated shuttle...

Demonstration and Evaluation of the Effects of Incentives on Resource Sharing Using a Computerized Interlibrary Communications System.

ERIC Educational Resources Information Center

New England Board of Higher Education, Wellesley, MA. New England Library Information Network.

The potential for using a computerized communication system to facilitate resource sharing in New England has been investigated by the staff of the New England Information Network (NELINET). The central purpose of their research was to determine whether a strategy for load leveling of interlibrary loan (ILL) requests could be implemented online as…

Mechanical load induces sarcoplasmic wounding and FGF release in differentiated human skeletal muscle cultures

NASA Technical Reports Server (NTRS)

Clarke, M. S.; Feeback, D. L.

1996-01-01

The transduction mechanism (or mechanisms) responsible for converting a mechanical load into a skeletal muscle growth response are unclear. In this study we have used a mechanically active tissue culture model of differentiated human skeletal muscle cells to investigate the relationship between mechanical load, sarcolemma wounding, fibroblast growth factor release, and skeletal muscle cell growth. Using the Flexcell Strain Unit we demonstrate that as mechanical load increases, so too does the amount of sarcolemma wounding. A similar relationship was also observed between the level of mechanical load inflicted on the cells and the amount of bFGF (FGF2) released into the surrounding medium. In addition, we demonstrate that the muscle cell growth response induced by chronic mechanical loading in culture can be inhibited by the presence of an antibody capable of neutralizing the biological activity of FGF. This study provides direct evidence that mechanically induced, sarcolemma wound-mediated FGF release is an important autocrine mechanism for transducing the stimulus of mechanical load into a skeletal muscle growth response.

Intelligent Energy Management System for PV-Battery-based Microgrids in Future DC Homes

NASA Astrophysics Data System (ADS)

Chauhan, R. K.; Rajpurohit, B. S.; Gonzalez-Longatt, F. M.; Singh, S. N.

2016-06-01

This paper presents a novel intelligent energy management system (IEMS) for a DC microgrid connected to the public utility (PU), photovoltaic (PV) and multi-battery bank (BB). The control objectives of the proposed IEMS system are: (i) to ensure the load sharing (according to the source capacity) among sources, (ii) to reduce the power loss (high efficient) in the system, and (iii) to enhance the system reliability and power quality. The proposed IEMS is novel because it follows the ideal characteristics of the battery (with some assumptions) for the power sharing and the selection of the closest source to minimize the power losses. The IEMS allows continuous and accurate monitoring with intelligent control of distribution system operations such as battery bank energy storage (BBES) system, PV system and customer utilization of electric power. The proposed IEMS gives the better operational performance for operating conditions in terms of load sharing, loss minimization, and reliability enhancement of the DC microgrid.

Understanding negative impacts of perceived cognitive load on job learning effectiveness: a social capital solution.

PubMed

Lin, Chieh-Peng

2010-12-01

This study proposes a model explaining how social capital helps ease excessively required mental effort. Although organizational researchers have studied both social capital and cognitive load, no prior research has critically examined the role of social capital in improving individuals' mental load and effort and consequently enhancing job learning effectiveness. This study surveys participants made up of professionals in Taiwan's information technology industry. It measures the constructs with the use of 5-point Likert-type scale items modified from existing literature. The survey data were analyzed with the use of structural equation modeling. Job learning effectiveness is negatively influenced by role ambiguity and role conflict. Time pressure has a positive influence on role ambiguity and role conflict Although the relationship between task complexity and role ambiguity is insignificant, task complexity has a positive influence on role conflict. Because the relationship between network ties and role conflict is insignificant, trust has a negative influence on role conflict. Last, shared vision has a negative influence on role ambiguity. This study provides an example of how social capital can be applied as a useful remedy to ease the negative impact of perceived cognitive load on job learning effectiveness. The negative relationship between shared vision and role ambiguity suggests that a shared vision helps in disseminating organizationally common goals and directions among employees to alleviate individuals' mental efforts in dealing with the ambiguity of their job roles. A firm's management team should take actions to decrease role conflict by strengthening trust among employees.

Load sharing in distributed real-time systems with state-change broadcasts

NASA Technical Reports Server (NTRS)

Shin, Kang G.; Chang, Yi-Chieh

1989-01-01

A decentralized dynamic load-sharing (LS) method based on state-change broadcasts is proposed for a distributed real-time system. Whenever the state of a node changes from underloaded to fully loaded and vice versa, the node broadcasts this change to a set of nodes, called a buddy set, in the system. The performance of the method is evaluated with both analytic modeling and simulation. It is modeled first by an embedded Markov chain for which numerical solutions are derived. The model solutions are then used to calculate the distribution of queue lengths at the nodes and the probability of meeting task deadlines. The analytical results show that buddy sets of 10 nodes outperform those of less than 10 nodes, and the incremental benefit gained from increasing the buddy set size beyond 15 nodes is insignificant. These and other analytical results are verified by simulation. The proposed LS method is shown to meet task deadlines with a very high probability.

Polygenic loading for major depression is associated with specific medical comorbidity

PubMed Central

McCoy, T H; Castro, V M; Snapper, L; Hart, K; Januzzi, J L; Huffman, J C; Perlis, R H

2017-01-01

Major depressive disorder frequently co-occurs with medical disorders, raising the possibility of shared genetic liability. Recent identification of 15 novel genetic loci associated with depression allows direct investigation of this question. In cohorts of individuals participating in biobanks at two academic medical centers, we calculated polygenic loading for risk loci reported to be associated with depression. We then examined the association between such loading and 50 groups of clinical diagnoses, or topics, drawn from these patients' electronic health records, determined using a novel application of latent Dirichilet allocation. Three topics showed experiment-wide association with the depression liability score; these included diagnostic groups representing greater prevalence of mood and anxiety disorders, greater prevalence of cardiac ischemia, and a decreased prevalence of heart failure. The latter two associations persisted even among individuals with no mood disorder diagnosis. This application of a novel method for grouping related diagnoses in biobanks indicate shared genetic risk for depression and cardiac disease, with a pattern suggesting greater ischemic risk and diminished heart failure risk. PMID:28926002

Testing Orions Fairing Separation System

NASA Technical Reports Server (NTRS)

Martinez, Henry; Cloutier, Chris; Lemmon, Heber; Rakes, Daniel; Oldham, Joe; Schlagel, Keith

2014-01-01

Traditional fairing systems are designed to fully encapsulate and protect their payload from the harsh ascent environment including acoustic vibrations, aerodynamic forces and heating. The Orion fairing separation system performs this function and more by also sharing approximately half of the vehicle structural load during ascent. This load-share condition through launch and during jettison allows for a substantial increase in mass to orbit. A series of component-level development tests were completed to evaluate and characterize each component within Orion's unique fairing separation system. Two full-scale separation tests were performed to verify system-level functionality and provide verification data. This paper summarizes the fairing spring, Pyramidal Separation Mechanism and forward seal system component-level development tests, system-level separation tests, and lessons learned.

Dynamic programming on a shared-memory multiprocessor

NASA Technical Reports Server (NTRS)

Edmonds, Phil; Chu, Eleanor; George, Alan

1993-01-01

Three new algorithms for solving dynamic programming problems on a shared-memory parallel computer are described. All three algorithms attempt to balance work load, while keeping synchronization cost low. In particular, for a multiprocessor having p processors, an analysis of the best algorithm shows that the arithmetic cost is O(n-cubed/6p) and that the synchronization cost is O(absolute value of log sub C n) if p much less than n, where C = (2p-1)/(2p + 1) and n is the size of the problem. The low synchronization cost is important for machines where synchronization is expensive. Analysis and experiments show that the best algorithm is effective in balancing the work load and producing high efficiency.

Early-shared Mycobacterium bovis bacillus Calmette-Guérin sub-strains induce Th1 cytokine production in vivo.

PubMed

Taniguchi, Keiichi; Miyatake, Yuuji; Hayashi, Daisuke; Takami, Atsuro; Itoh, Saotomo; Yamamoto, Saburo; Hida, Shigeaki; Onozaki, Kikuo; Takii, Takemasa

2015-11-01

Interleukin-12 is one of the cytokines that induce acquired immunity by progressing the differentiation of T cells. When antigens are presented by APCs, including macrophages and DCs, T cells are activated and produce the Th1 cytokines IL-2 and IFN-γ. We have previously reported greater IL-12 production from macrophages infected with early-shared BCG sub-strains (ex. BCG-Japan, -Sweden) than from those infected with late-shared BCG (ex. BCG-Pasteur and -Connaught) . In this study, we investigated the Th1 cytokine-inducing activity of splenocytes co-cultured with BCG-infected DCs. Early-shared BCG-infected DCs produced IL-12 and TNF-α⋅ Furthermore, when they were co-cultured with purified protein derivative-stimulated DCs, the splenocytes of mice immunized with BCG-Tokyo/Japan produced more Th1 cytokine than did those of mice immunized with BCG-Connaught. In conclusion, early-shared BCG sub-strains more strongly induce Th1 cytokine production in vivo. This study provides basic information to inform the selection of candidates for primary vaccination. © 2015 The Societies and Wiley Publishing Asia Pty Ltd.

Microgrid Study: Energy Security for DoD Installations

DTIC Science & Technology

2012-06-18

security, efficiency, and the incorporation of renewable and distributed energy resources into microgrids, as well as the factors that might facilitate...better understand how different environmental factors affected the choice of optimal microgrid architecture. Environmental factors in this context...lower costs—Networking generation assets allow for load sharing, allowing fewer generators to run at higher load factors and therefore with greater

Water Flow Testing and Unsteady Pressure Analysis of a Two-Bladed Liquid Oxidizer Pump Inducer

NASA Technical Reports Server (NTRS)

Schwarz, Jordan B.; Mulder, Andrew; Zoladz, Thomas

2011-01-01

The unsteady fluid dynamic performance of a cavitating two-bladed oxidizer turbopump inducer was characterized through sub-scale water flow testing. While testing a novel inlet duct design that included a cavitation suppression groove, unusual high-frequency pressure oscillations were observed. With potential implications for inducer blade loads, these high-frequency components were analyzed extensively in order to understand their origins and impacts to blade loading. Water flow testing provides a technique to determine pump performance without the costs and hazards associated with handling cryogenic propellants. Water has a similar density and Reynolds number to liquid oxygen. In a 70%-scale water flow test, the inducer-only pump performance was evaluated. Over a range of flow rates, the pump inlet pressure was gradually reduced, causing the flow to cavitate near the pump inducer. A nominal, smooth inducer inlet was tested, followed by an inlet duct with a circumferential groove designed to suppress cavitation. A subsequent 52%-scale water flow test in another facility evaluated the combined inducer-impeller pump performance. With the nominal inlet design, the inducer showed traditional cavitation and surge characteristics. Significant bearing loads were created by large side loads on the inducer during synchronous cavitation. The grooved inlet successfully mitigated these loads by greatly reducing synchronous cavitation, however high-frequency pressure oscillations were observed over a range of frequencies. Analytical signal processing techniques showed these oscillations to be created by a rotating, multi-celled train of pressure pulses, and subsequent CFD analysis suggested that such pulses could be created by the interaction of rotating inducer blades with fluid trapped in a cavitation suppression groove. Despite their relatively low amplitude, these high-frequency pressure oscillations posed a design concern due to their sensitivity to flow conditions and test scale. The amplitude and frequency of oscillations varied considerably over the pump s operating space, making it difficult to predict blade loads.

Cross-Priming of Naive Cd8 T Cells against Melanoma Antigens Using Dendritic Cells Loaded with Killed Allogeneic Melanoma Cells

PubMed Central

Berard, Frederic; Blanco, Patrick; Davoust, Jean; Neidhart-Berard, Eve-Marie; Nouri-Shirazi, Mahyar; Taquet, Nicolas; Rimoldi, Donata; Cerottini, Jean Charles; Banchereau, Jacques; Palucka, A. Karolina

2000-01-01

The goal of tumor immunotherapy is to elicit immune responses against autologous tumors. It would be highly desirable that such responses include multiple T cell clones against multiple tumor antigens. This could be obtained using the antigen presenting capacity of dendritic cells (DCs) and cross-priming. That is, one could load the DC with tumor lines of any human histocompatibility leukocyte antigen (HLA) type to elicit T cell responses against the autologous tumor. In this study, we show that human DCs derived from monocytes and loaded with killed melanoma cells prime naive CD45RA+CD27+CD8+ T cells against the four shared melanoma antigens: MAGE-3, gp100, tyrosinase, and MART-1. HLA-A201+ naive T cells primed by DCs loaded with HLA-A201− melanoma cells are able to kill several HLA-A201+ melanoma targets. Cytotoxic T lymphocyte priming towards melanoma antigens is also obtained with cells from metastatic melanoma patients. This demonstration of cross-priming against shared tumor antigens builds the basis for using allogeneic tumor cell lines to deliver tumor antigens to DCs for vaccination protocols. PMID:11104796

RNA Expression Analysis of Passive Transfer Myasthenia Supports Extraocular Muscle as a Unique Immunological Environment

PubMed Central

Zhou, Yuefang; Kaminski, Henry J.; Gong, Bendi; Cheng, Georgiana; Feuerman, Jason M.; Kusner, Linda

2014-01-01

Purpose. Myasthenia gravis demonstrates a distinct predilection for involvement of the extraocular muscles (EOM), and we have hypothesized that this may be due to a unique immunological environment. To assess this hypothesis, we took an unbiased approach to analyze RNA expression profiles in EOM, diaphragm, and extensor digitorum longus (EDL) in rats with experimentally acquired myasthenia gravis (EAMG). Methods. Experimentally acquired myasthenia gravis was induced in rats by intraperitoneal injection of antibody directed against the acetylcholine receptor (AChR), whereas control rats received antibody known to bind the AChR but not induce disease. After 48 hours, animals were killed and muscles analyzed by RNA expression profiling. Profiling results were validated using qPCR and immunohistochemical analysis. Results. Sixty-two genes common among all muscle groups were increased in expression. These fell into four major categories: 12.8% stress response, 10.5% immune response, 10.5% metabolism, and 9.0% transcription factors. EOM expressed 212 genes at higher levels, not shared by the other two muscles, and a preponderance of EOM gene changes fell into the immune response category. EOM had the most uniquely reduced genes (126) compared with diaphragm (26) and EDL (50). Only 18 downregulated genes were shared by the three muscles. Histological evaluation and disease load index (sum of fold changes for all genes) demonstrated that EOM had the greatest degree of pathology. Conclusions. Our studies demonstrated that consistent with human myasthenia gravis, EOM demonstrates a distinct RNA expression signature from EDL and diaphragm, which is based on differences in the degree of muscle injury and inflammatory response. PMID:24917137

Task-irrelevant memory load induces inattentional blindness without temporo-parietal suppression.

PubMed

Matsuyoshi, Daisuke; Ikeda, Takashi; Sawamoto, Nobukatsu; Kakigi, Ryusuke; Fukuyama, Hidenao; Osaka, Naoyuki

2010-08-01

We often fail to consciously detect an unexpected object when we are engaged in an attention-demanding task (inattentional blindness). The inattentional blindness which is induced by visual short-term memory (VSTM) load has been proposed to result from a suppression of temporo-parietal junction (TPJ) activity that involves stimulus-driven attention. However, the fact that, inversely proportional to TPJ activity, intraparietal sulcus (IPS) activity correlates with VSTM load renders questionable the account of inattentional blindness based only on TPJ activity. Here, we investigated whether the TPJ is solely responsible for inattentional blindness by decoupling IPS and TPJ responses to VSTM load and then using the same manipulation to test the behavioral inattentional blindness performance. Experiment 1 showed that TPJ activity was not suppressed by task-irrelevant load while the IPS responded to both task-relevant and task-irrelevant load. Although the TPJ account of inattentional blindness predicts that the degree of inattentional blindness should track TPJ activity, we found in Experiment 2 that inattentional blindness was induced not only by task-relevant load but also by task-irrelevant load, showing inconsistency between the extent of inattentional blindness and TPJ response. These findings suggest that inattentional blindness can be induced without suppression of TPJ activity and seem to offer the possibility that the IPS contributes to conscious perception. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

Exercise-Induced Bronchoconstriction Quiz

MedlinePlus

... navigation Home ▸ Conditions & Treatments ▸ Asthma ▸ EIB Quiz Share | Exercise-Induced Bronchoconstriction or Exercise-Induced Asthma Quiz Exercise-Induced Bronchoconstriction (also called ...

Effects of Loading Duration and Short Rest Insertion on Cancellous and Cortical Bone Adaptation in the Mouse Tibia

PubMed Central

Yang, Haisheng; Embry, Rachel E.; Main, Russell P.

2017-01-01

The skeleton’s osteogenic response to mechanical loading can be affected by loading duration and rest insertion during a series of loading events. Prior animal loading studies have shown that the cortical bone response saturates quickly and short rest insertions between load cycles can enhance cortical bone formation. However, it remains unknown how loading duration and short rest insertion affect load-induced osteogenesis in the mouse tibial compressive loading model, and particularly in cancellous bone. To address this issue, we applied cyclic loading (-9 N peak load; 4 Hz) to the tibiae of three groups of 16 week-old female C57BL/6 mice for two weeks, with a different number of continuous load cycles applied daily to each group (36, 216 and 1200). A fourth group was loaded under 216 daily load cycles with a 10 s rest insertion after every fourth cycle. We found that as few as 36 load cycles per day were able to induce osteogenic responses in both cancellous and cortical bone. Furthermore, while cortical bone area and thickness continued to increase through 1200 cycles, the incremental increase in the osteogenic response decreased as load number increased, indicating a reduced benefit of the increasing number of load cycles. In the proximal metaphyseal cancellous bone, trabecular thickness increased with load up to 216 cycles. We also found that insertion of a 10 s rest between load cycles did not improve the osteogenic response of the cortical or cancellous tissues compared to continuous loading in this model given the age and sex of the mice and the loading parameters used here. These results suggest that relatively few load cycles (e.g. 36) are sufficient to induce osteogenic responses in both cortical and cancellous bone in the mouse tibial loading model. Mechanistic studies using the mouse tibial loading model to examine bone formation and skeletal mechanobiology could be accomplished with relatively few load cycles. PMID:28076363

Real-Time Measurement of Solute Transport Within the Lacunar-Canalicular System of Mechanically Loaded Bone: Direct Evidence for Load-Induced Fluid Flow

PubMed Central

Price, Christopher; Zhou, Xiaozhou; Li, Wen; Wang, Liyun

2011-01-01

Since proposed by Piekarski and Munro in 1977, load-induced fluid flow through the bone lacunar-canalicular system (LCS) has been accepted as critical for bone metabolism, mechanotransduction, and adaptation. However, direct unequivocal observation and quantification of load-induced fluid and solute convection through the LCS have been lacking due to technical difficulties. Using a novel experimental approach based on fluorescence recovery after photobleaching (FRAP) and synchronized mechanical loading and imaging, we successfully quantified the diffusive and convective transport of a small fluorescent tracer (sodium fluorescein, 376 Da) in the bone LCS of adult male C57BL/6J mice. We demonstrated that cyclic end-compression of the mouse tibia with a moderate loading magnitude (–3 N peak load or 400 µɛ surface strain at 0.5 Hz) and a 4-second rest/imaging window inserted between adjacent load cycles significantly enhanced (+31%) the transport of sodium fluorescein through the LCS compared with diffusion alone. Using an anatomically based three-compartment transport model, the peak canalicular fluid velocity in the loaded bone was predicted (60 µm/s), and the resulting peak shear stress at the osteocyte process membrane was estimated (∼5 Pa). This study convincingly demonstrated the presence of load-induced convection in mechanically loaded bone. The combined experimental and mathematical approach presented herein represents an important advance in quantifying the microfluidic environment experienced by osteocytes in situ and provides a foundation for further studying the mechanisms by which mechanical stimulation modulates osteocytic cellular responses, which will inform basic bone biology, clinical understanding of osteoporosis and bone loss, and the rational engineering of their treatments. © 2011 American Society for Bone and Mineral Research. PMID:20715178

Failure criterion for materials with spatially correlated mechanical properties

NASA Astrophysics Data System (ADS)

Faillettaz, J.; Or, D.

2015-03-01

The role of spatially correlated mechanical elements in the failure behavior of heterogeneous materials represented by fiber bundle models (FBMs) was evaluated systematically for different load redistribution rules. Increasing the range of spatial correlation for FBMs with local load sharing is marked by a transition from ductilelike failure characteristics into brittlelike failure. The study identified a global failure criterion based on macroscopic properties (external load and cumulative damage) that is independent of spatial correlation or load redistribution rules. This general metric could be applied to assess the mechanical stability of complex and heterogeneous systems and thus provide an important component for early warning of a class of geophysical ruptures.

Transformation-Induced Diffraction Peak Broadening During Bainitic and Martensitic Transformations Under Small External Loads in a Quenched and Tempered High Strength Steel

NASA Astrophysics Data System (ADS)

Dutta, R. K.; Huizenga, R. M.; Amirthalingam, M.; Hermans, M. J. M.; King, A.; Richardson, I. M.

2013-09-01

In situ phase transformation behavior of a high strength S690QL1 steel during continuous cooling under different mechanical loading conditions has been used to investigate the effect of small external loads on the transformation-induced plasticity during bainitic and martensitic transformations. The results show that during phase transformations, the untransformed austenite undergoes plastic deformation, thereby retarding further transformation to bainite/martensite. This occurs independent of external load.

Low rate loading-induced convection enhances net transport into the intervertebral disc in vivo.

PubMed

Gullbrand, Sarah E; Peterson, Joshua; Mastropolo, Rosemarie; Roberts, Timothy T; Lawrence, James P; Glennon, Joseph C; DiRisio, Darryl J; Ledet, Eric H

2015-05-01

The intervertebral disc primarily relies on trans-endplate diffusion for the uptake of nutrients and the clearance of byproducts. In degenerative discs, diffusion is often diminished by endplate sclerosis and reduced proteoglycan content. Mechanical loading-induced convection has the potential to augment diffusion and enhance net transport into the disc. The ability of convection to augment disc transport is controversial and has not been demonstrated in vivo. To determine if loading-induced convection can enhance small molecule transport into the intervertebral disc in vivo. Net transport was quantified via postcontrast enhanced magnetic resonance imaging (MRI) into the discs of the New Zealand white rabbit lumbar spine subjected to in vivo cyclic low rate loading. Animals were administered the MRI contrast agent gadodiamide intravenously and subjected to in vivo low rate loading (0.5 Hz, 200 N) via a custom external loading apparatus for either 2.5, 5, 10, 15, or 20 minutes. Animals were then euthanized and the lumbar spines imaged using postcontrast enhanced MRI. The T1 constants in the nucleus, annulus, and cartilage endplates were quantified as a measure of gadodiamide transport into the loaded discs compared with the adjacent unloaded discs. Microcomputed tomography was used to quantify subchondral bone density. Low rate loading caused the rapid uptake and clearance of gadodiamide in the nucleus compared with unloaded discs, which exhibited a slower rate of uptake. Relative to unloaded discs, low rate loading caused a maximum increase in transport into the nucleus of 16.8% after 5 minutes of loading. Low rate loading increased the concentration of gadodiamide in the cartilage endplates at each time point compared with unloaded levels. Results from this study indicate that forced convection accelerated small molecule uptake and clearance in the disc induced by low rate mechanical loading. Low rate loading may, therefore, be therapeutic to the disc as it may enhance the nutrient uptake and waste product clearance. Copyright © 2015 Elsevier Inc. All rights reserved.

Matroids and quantum-secret-sharing schemes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sarvepalli, Pradeep; Raussendorf, Robert

A secret-sharing scheme is a cryptographic protocol to distribute a secret state in an encoded form among a group of players such that only authorized subsets of the players can reconstruct the secret. Classically, efficient secret-sharing schemes have been shown to be induced by matroids. Furthermore, access structures of such schemes can be characterized by an excluded minor relation. No such relations are known for quantum secret-sharing schemes. In this paper we take the first steps toward a matroidal characterization of quantum-secret-sharing schemes. In addition to providing a new perspective on quantum-secret-sharing schemes, this characterization has important benefits. While previousmore » work has shown how to construct quantum-secret-sharing schemes for general access structures, these schemes are not claimed to be efficient. In this context the present results prove to be useful; they enable us to construct efficient quantum-secret-sharing schemes for many general access structures. More precisely, we show that an identically self-dual matroid that is representable over a finite field induces a pure-state quantum-secret-sharing scheme with information rate 1.« less

Electroencephalography Based Analysis of Working Memory Load and Affective Valence in an N-back Task with Emotional Stimuli

PubMed Central

Grissmann, Sebastian; Faller, Josef; Scharinger, Christian; Spüler, Martin; Gerjets, Peter

2017-01-01

Most brain-based measures of the electroencephalogram (EEG) are used in highly controlled lab environments and only focus on narrow mental states (e.g., working memory load). However, we assume that outside the lab complex multidimensional mental states are evoked. This could potentially create interference between EEG signatures used for identification of specific mental states. In this study, we aimed to investigate more realistic conditions and therefore induced a combination of working memory load and affective valence to reveal potential interferences in EEG measures. To induce changes in working memory load and affective valence, we used a paradigm which combines an N-back task (for working memory load manipulation) with a standard method to induce affect (affective pictures taken from the International Affective Picture System (IAPS) database). Subjective ratings showed that the experimental task was successful in inducing working memory load as well as affective valence. Additionally, performance measures were analyzed and it was found that behavioral performance decreased with increasing workload as well as negative valence, showing that affective valence can have an effect on cognitive processing. These findings are supported by changes in frontal theta and parietal alpha power, parameters used for measuring of working memory load in the EEG. However, these EEG measures are influenced by the negative valence condition as well and thereby show that detection of working memory load is sensitive to affective contexts. Unexpectedly, we did not find any effects for EEG measures typically used for affective valence detection (Frontal Alpha Asymmetry (FAA)). Therefore we assume that the FAA measure might not be usable if cognitive workload is induced simultaneously. We conclude that future studies should account for potential context-specifity of EEG measures. PMID:29311875

Electroencephalography Based Analysis of Working Memory Load and Affective Valence in an N-back Task with Emotional Stimuli.

PubMed

Grissmann, Sebastian; Faller, Josef; Scharinger, Christian; Spüler, Martin; Gerjets, Peter

2017-01-01

Most brain-based measures of the electroencephalogram (EEG) are used in highly controlled lab environments and only focus on narrow mental states (e.g., working memory load). However, we assume that outside the lab complex multidimensional mental states are evoked. This could potentially create interference between EEG signatures used for identification of specific mental states. In this study, we aimed to investigate more realistic conditions and therefore induced a combination of working memory load and affective valence to reveal potential interferences in EEG measures. To induce changes in working memory load and affective valence, we used a paradigm which combines an N-back task (for working memory load manipulation) with a standard method to induce affect (affective pictures taken from the International Affective Picture System (IAPS) database). Subjective ratings showed that the experimental task was successful in inducing working memory load as well as affective valence. Additionally, performance measures were analyzed and it was found that behavioral performance decreased with increasing workload as well as negative valence, showing that affective valence can have an effect on cognitive processing. These findings are supported by changes in frontal theta and parietal alpha power, parameters used for measuring of working memory load in the EEG. However, these EEG measures are influenced by the negative valence condition as well and thereby show that detection of working memory load is sensitive to affective contexts. Unexpectedly, we did not find any effects for EEG measures typically used for affective valence detection (Frontal Alpha Asymmetry (FAA)). Therefore we assume that the FAA measure might not be usable if cognitive workload is induced simultaneously. We conclude that future studies should account for potential context-specifity of EEG measures.

The Molecular Basis for Load-Induced Skeletal Muscle Hypertrophy

PubMed Central

Marcotte, George R.; West, Daniel W.D.; Baar, Keith

2016-01-01

In a mature (weight neutral) animal, an increase in muscle mass only occurs when the muscle is loaded sufficiently to cause an increase in myofibrillar protein balance. A tight relationship between muscle hypertrophy, acute increases in protein balance, and the activity of the mechanistic target of rapamycin complex 1 (mTORC1) was demonstrated 15 years ago. Since then, our understanding of the signals that regulate load-induced hypertrophy has evolved considerably. For example, we now know that mechanical load activates mTORC1 in the same way as growth factors, by moving TSC2 (a primary inhibitor of mTORC1) away from its target (the mTORC activator) Rheb. However, the kinase that phosphorylates and moves TSC2 is different in the two processes. Similarly, we have learned that a distinct pathway exists whereby amino acids activate mTORC1 by moving it to Rheb. While mTORC1 remains at the forefront of load-induced hypertrophy, the importance of other pathways that regulate muscle mass are becoming clearer. Myostatin, is best known for its control of developmental muscle size. However, new mechanisms to explain how loading regulates this process are suggesting that it could play an important role in hypertrophic muscle growth as well. Lastly, new mechanisms are highlighted for how β2 receptor agonists could be involved in load-induced muscle growth and why these agents are being developed as non-exercise-based therapies for muscle atrophy. Overall, the results highlight how studying the mechanism of load-induced skeletal muscle mass is leading the development of pharmaceutical interventions to promote muscle growth in those unwilling or unable to perform resistance exercise. PMID:25359125

AIR VEHICLES INTEGRATION AND TECHNOLOGY RESEARCH (AVIATR) Task Order 0015: Predictive Capability for Hypersonic Structural Response and Life Prediction Phase 1 - Identification of Knowledge Gaps

DTIC Science & Technology

2010-08-01

using load - bearing tanks with parasitic TPS was considered to be a lower weight design when all details were accounted for. The cold structure...share one very key element with the design of load bearing hot structure – the design drive toward thin gauge metallic skin under complex and coupled...39 skin panel joints and their susceptibility to high acoustic loading coupled with transient heating, and hot structure skin deflections and

Gearbox Reliability Collaborative Gearbox 3 Planet Bearing Calibration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keller, Jonathan

2017-03-24

The Gearbox Reliability Collaborative gearbox was redesigned to improve its load-sharing characteristics and predicted fatigue life. The most important aspect of the redesign was to replace the cylindrical roller bearings with preloaded tapered roller bearings in the planetary section. Similar to previous work, the strain gages installed on the planet tapered roller bearings were calibrated in a load frame. This report describes the calibration tests and provides the factors necessary to convert the measured units from dynamometer testing to bearing loads, suitable for comparison to engineering models.

Thermal performance of a multi-evaporator loop heat pipe with thermal masses and thermal electrical coolers

NASA Technical Reports Server (NTRS)

Ku, Jentung; Ottenstein, Laura; Birur, Gajanana

2004-01-01

This paper describes thermal performance of a loop heat pipe (LHP) with two evaporators and two condensers in ambient testing. Each evaporator has an outer diameter of 15mm and a length of 76mm, and has an integral compensation chamber (CC). An aluminum mass of 500 grams is attached to each evaporator to simulate the instrument mass. A thermal electric cooler (TEC) is installed on each CC to provide heating as well as cooling for CC temperature control. A flow regulator is installed in the condenser section to prevent vapor from going back to the evaporators in the event that one of condenser is fully utilized. Ammonia was used ad the working fluid. Tests conducted included start-up, power cycle, heat load sharing, sink temperature cycle, operating temperature control with TECs, and capillary limit tests. Experimental data showed that the loop could start with a heat load of less than 1OW even with added thermal masses. The loop operated stably with even and uneven evaporator heat loads, and even and uneven condenser sink temperatures. The operating temperature could be controlled within +/-0.5K of the set point temperature using either or both TECs, and the required TEC control heater power was less than 2W under most test conditions. Heat load sharing between the two evaporators was also successfully demonstrated. The loop had a heat transport capability of 120W to 140W, and could recover from a dry-out when the heat load was reduced. The 500-gram aluminum mass on each evaporator had a negligible effect on the loop operation. Existing LHPs servicing the orbiting spacecraft have a single evaporator with an outer diameter of about 25mm. Important performance characteristics demonstrated by this LHP included: 1) Operation of an LHP with 15mm diameter evaporators; 2) Robustness and reliability of an LHP with multiple evaporators and multiple condensers under various test conditions; 3) Heat load sharing among LHP evaporators; 4) Effectiveness of TECs in controlling the LHP operating temperature; and 5) Effectiveness of the flow regulator in preventing vapor from going back the evaporators.

Thermal Performance of a Multi-Evaporator Loop Heat Pipe with Thermal Masses and Thermoelectric Coolers

NASA Technical Reports Server (NTRS)

Ku, Jen-Tung; Ottenstein, Laura; Birur, Gajanana

2004-01-01

This paper describes thermal performance of a loop heat pipe (LHP) with two evaporators and two condensers in ambient testing. Each evaporator has an outer diameter of 15mm and a length of 76mm, and has an integral compensation chamber (CC). An aluminum mass of 500 grams is attached to each evaporator to simulate the instrument mass. A thermoelectric cooler (TEC) is installed on each CC to provide heating as well as cooling for CC temperature control. A flow regulator is installed in the condenser section to prevent vapor from going back to the evaporators in the event that one of the condensers is fully utilized. Ammonia was used as the working fluid. Tests conducted included start-up, power cycle, heat load sharing, sink temperature cycle, operating temperature control with TECs, and capillary limit tests. Experimental data showed that the loop could start with a heat load of less than 10W even with added thermal masses. The loop operated stably with even and uneven evaporator heat loads, and even and uneven condenser sink temperatures. The operating temperature could be controlled within +/- 0.5K of the set point temperature using either or both TECs, and the required TEC control heater power was less than 2W under most test conditions. Heat load sharing between the two evaporators was also successfully demonstrated. The loop had a heat transport capability of 120W to 140W, and could recover from a dry-out when the heat load was reduced. The 500-gram aluminum mass on each evaporator had a negligible effect on the loop operation. Existing LHPs servicing orbiting spacecraft have a single evaporator with an outer diameter of about 25mm. Important performance characteristics demonstrated by this LHP included: 1) Operation of an LHP with 15mm diameter evaporators; 2) Robustness and reliability of an LHP with multiple evaporators and multiple condensers under various test conditions; 3) Heat load sharing among LHP evaporators; 4) Effectiveness of TECs in controlling the LHP operating temperature; and 5 ) Effectiveness of the flow regulator in preventing vapor from going back the evaporators.

Effect of loading speed on the stress-induced magnetic behavior of ferromagnetic steel

NASA Astrophysics Data System (ADS)

Bao, Sheng; Gu, Yibin; Fu, Meili; Zhang, Da; Hu, Shengnan

2017-02-01

The primary goal of this research is to investigate the effect of loading speed on the stress-induced magnetic behavior of a ferromagnetic steel. Uniaxial tension tests on Q235 steel were carried out with various stress levels under different loading speeds. The variation of the magnetic signals surrounding the tested specimen was detected by a fluxgate magnetometer. The results indicated that the magnetic signal variations depended not only on the tensile load level but on the loading speed during the test. The magnetic field amplitude seemed to decrease gradually with the increase in loading speed at the same tensile load level. Furthermore, the evolution of the magnetic reversals is also related to the loading speed. Accordingly, the loading speed should be considered as one of the influencing variables in the Jies-Atherton model theory of the magnetomechanical effect.

Load induced blindness.

PubMed

Macdonald, James S P; Lavie, Nilli

2008-10-01

Although the perceptual load theory of attention has stimulated a great deal of research, evidence for the role of perceptual load in determining perception has typically relied on indirect measures that infer perception from distractor effects on reaction times or neural activity (see N. Lavie, 2005, for a review). Here we varied the level of perceptual load in a letter-search task and assessed its effect on the conscious perception of a search-irrelevant shape stimulus appearing in the periphery, using a direct measure of awareness (present/absent reports). Detection sensitivity (d') was consistently reduced with high, compared to low, perceptual load but was unaffected by the level of working memory load. Because alternative accounts in terms of expectation, memory, response bias, and goal-neglect due to the more strenuous high load task were ruled out, these experiments clearly demonstrate that high perceptual load determines conscious perception, impairing the ability to merely detect the presence of a stimulus--a phenomenon of load induced blindness.

Computer simulation of the effects of shoe cushioning on internal and external loading during running impacts.

PubMed

Miller, Ross H; Hamill, Joseph

2009-08-01

Biomechanical aspects of running injuries are often inferred from external loading measurements. However, previous research has suggested that relationships between external loading and potential injury-inducing internal loads can be complex and nonintuitive. Further, the loading response to training interventions can vary widely between subjects. In this study, we use a subject-specific computer simulation approach to estimate internal and external loading of the distal tibia during the impact phase for two runners when running in shoes with different midsole cushioning parameters. The results suggest that: (1) changes in tibial loading induced by footwear are not reflected by changes in ground reaction force (GRF) magnitudes; (2) the GRF loading rate is a better surrogate measure of tibial loading and stress fracture risk than the GRF magnitude; and (3) averaging results across groups may potentially mask differential responses to training interventions between individuals.

Experimental Investigations in Nonlinear Viscous Behavior of Subgrade Soils Under Traffic-Induced Loading

DOT National Transportation Integrated Search

1999-08-01

This paper concerns experimental investigations of nonlinear viscosity of : subgrade soils under vehicle-induced loading. Subgrade soil samples--collected : from the Soil/Aggregate Laboratory at the Geotechnical Exploration Division at : the Maryland...

A tale of two cultures: specialists and generalists sharing the load.

PubMed

Manca, Donna P; Breault, Lorraine; Wishart, Paul

2011-05-01

To understand what contributes to good collaborative physician working relationships through identifying the factors that affect working relationships between generalist physicians and specialists. Qualitative study using in-depth interviews. University and community hospital inpatient family practice settings in Edmonton, Alta. Eleven physicians from various specialties who graduated between 1977 and 2001. A grounded-theory approach, including constant comparison and creation of memorandums, helped to conceptualize the main concern and generated a framework for how the main concern was being resolved. A semistructured interview guide was developed and individual, in-depth interviews were audiotaped. Purposeful and theoretical sampling techniques were used. Three researchers participated in the analysis. The findings suggested that when generalist physicians perceived that work had been imposed on them by specialists without negotiation, they felt overwhelmed by the workload. Differing priorities determined whether physicians were left holding the bag or sharing the load. In a system that valued technology and specialized knowledge and skills, the specialists were better able to control resources, set boundaries, and influence learners. This precipitated a culture of protecting valuable specialty resources, increasing physician isolation, and generalists feeling that they were left holding the bag. In order to reverse this cycle, it was important for physicians to develop good working relationships based on accessibility to needed expertise and tests, with negotiated agreements on how to share resources; mutual empowerment, including negotiation of roles and responsibilities to develop flexible relationships with a clear understanding of roles; and concern for fairness by sharing the load. Medical systems that value technology and focused interests might lead to someone being left holding the bag, contributing to generalists feeling overwhelmed and isolated within the system. A comprehensive system that values relationships might help to resolve issues created through perceived inequities in workload, disempowerment, and lack of understanding of roles.

The effects of acute stress and perceptual load on distractor interference.

PubMed

Sato, Hirotsune; Takenaka, Ippei; Kawahara, Jun I

2012-01-01

Selective attention can be improved under conditions in which a high perceptual load is assumed to exhaust cognitive resources, leaving scarce resources for distractor processing. The present study examined whether perceptual load and acute stress share common attentional resources by manipulating perceptual and stress loads. Participants identified a target within an array of nontargets that were flanked by compatible or incompatible distractors. Attentional selectivity was measured by longer reaction times in response to the incompatible than to the compatible distractors. Participants in the stress group participated in a speech test that increased anxiety and threatened self-esteem. The effect of perceptual load interacted with the stress manipulation in that participants in the control group demonstrated an interference effect under the low perceptual load condition, whereas such interference disappeared under the high perceptual load condition. Importantly, the stress group showed virtually no interference under the low perceptual load condition, whereas substantial interference occurred under the high perceptual load condition. These results suggest that perceptual and stress related demands consume the same attentional resources.

Study of inducer load and stress, volume 2

NASA Technical Reports Server (NTRS)

1972-01-01

A program of analysis, design, fabrication and testing has been conducted to develop computer programs for predicting rocket engine turbopump inducer hydrodynamic loading, stress magnitude and distribution, and vibration characteristics. Methods of predicting blade loading, stress, and vibration characteristics were selected from a literature search and used as a basis for the computer programs. An inducer, representative of typical rocket engine inducers, was designed, fabricated, and tested with special instrumentation selected to provide measurements of blade surface pressures and stresses. Data from the tests were compared with predicted values and the computer programs were revised as required to improve correlation. For Volume 1 see N71-20403. For Volume 2 see N71-20404.

Influence of fatigue crack wake length and state of stress on crack closure

NASA Technical Reports Server (NTRS)

Telesman, J.; Fisher, D. M.

1986-01-01

The location of crack closure with respect to crack wake and specimen thickness under different loading conditions was determined. The rate of increase of K sub CL in the crack wake was found to be significantly higher for plasticity induced closure in comparison to roughness induced closure. Roughness induced closure was uniform throughout the thickness of the specimen while plasticity induced closure levels were 50 percent higher in the near surface region than in the midthickness. The influence of state of stress on low-high load interaction effects was also examined. Load interaction effects differed depending upon the state of stress and were explained in terms of delta K sub eff.

Influence of fatigue crack wake length and state of stress on crack closure

NASA Technical Reports Server (NTRS)

Telesman, Jack; Fisher, Douglas M.

1988-01-01

The location of crack closure with respect to crack wake and specimen thickness under different loading conditions was determined. The rate of increase of K sub CL in the crack wake was found to be significantly higher for plasticity induced closure in comparison to roughness induced closure. Roughness induced closure was uniform throughout the thickness of the specimen while plasticity induced closure levels were 50 percent higher in the near surface region than in the midthickness. The influence of state of stress on low-high load interaction effects was also examined. Load interaction effects differed depending upon the state of stress and were explained in terms of delta K sub eff.

PWFQ: a priority-based weighted fair queueing algorithm for the downstream transmission of EPON

NASA Astrophysics Data System (ADS)

Xu, Sunjuan; Ye, Jiajun; Zou, Junni

2005-11-01

In the downstream direction of EPON, all ethernet frames share one downlink channel from the OLT to destination ONUs. To guarantee differentiated services, a scheduling algorithm is needed to solve the link-sharing issue. In this paper, we first review the classical WFQ algorithm and point out the shortcomings existing in the fair queueing principle of WFQ algorithm for EPON. Then we propose a novel scheduling algorithm called Priority-based WFQ (PWFQ) algorithm which distributes bandwidth based on priority. PWFQ algorithm can guarantee the quality of real-time services whether under light load or under heavy load. Simulation results also show that PWFQ algorithm not only can improve delay performance of real-time services, but can also meet the worst-case delay bound requirements.

SCC of 2304 Duplex Stainless Steel—Microstructure, Residual Stress and Surface Grinding Effects

PubMed Central

Zhou, Nian; Peng, Ru Lin; Schönning, Mikael; Pettersson, Rachel

2017-01-01

The influence of surface grinding and microstructure on chloride induced stress corrosion cracking (SCC) behavior of 2304 duplex stainless steel has been investigated. Grinding operations were performed both parallel and perpendicular to the rolling direction of the material. SCC tests were conducted in boiling magnesium chloride according to ASTM G36; specimens were exposed both without external loading and with varied levels of four-point bend loading. Residual stresses were measured on selected specimens before and after exposure using the X-ray diffraction technique. In addition, in-situ surface stress measurements subjected to four-point bend loading were performed to evaluate the deviation between the actual applied loading and the calculated values according to ASTM G39. Micro-cracks, initiated by grinding induced surface tensile residual stresses, were observed for all the ground specimens but not on the as-delivered surfaces. Loading transverse to the rolling direction of the material increased the susceptibility to chloride induced SCC. Grinding induced tensile residual stresses and micro-notches in the as-ground surface topography were also detrimental. PMID:28772582

SCC of 2304 Duplex Stainless Steel-Microstructure, Residual Stress and Surface Grinding Effects.

PubMed

Zhou, Nian; Peng, Ru Lin; Schönning, Mikael; Pettersson, Rachel

2017-02-23

The influence of surface grinding and microstructure on chloride induced stress corrosion cracking (SCC) behavior of 2304 duplex stainless steel has been investigated. Grinding operations were performed both parallel and perpendicular to the rolling direction of the material. SCC tests were conducted in boiling magnesium chloride according to ASTM G36; specimens were exposed both without external loading and with varied levels of four-point bend loading. Residual stresses were measured on selected specimens before and after exposure using the X-ray diffraction technique. In addition, in-situ surface stress measurements subjected to four-point bend loading were performed to evaluate the deviation between the actual applied loading and the calculated values according to ASTM G39. Micro-cracks, initiated by grinding induced surface tensile residual stresses, were observed for all the ground specimens but not on the as-delivered surfaces. Loading transverse to the rolling direction of the material increased the susceptibility to chloride induced SCC. Grinding induced tensile residual stresses and micro-notches in the as-ground surface topography were also detrimental.

Therapeutic effect of apatinib-loaded nanoparticles on diabetes-induced retinal vascular leakage.

PubMed

Jeong, Ji Hoon; Nguyen, Hong Khanh; Lee, Jung Eun; Suh, Wonhee

2016-01-01

Apatinib, a novel and selective inhibitor of vascular endothelial growth factor (VEGF) receptor 2, has been demonstrated recently to exhibit anticancer efficacy by inhibiting the VEGF signaling pathway. Given the importance of VEGF in retinal vascular leakage, the present study was designed to investigate whether apatinib-loaded polymeric nanoparticles inhibit VEGF-mediated retinal vascular hyperpermeability and block diabetes-induced retinal vascular leakage. For the delivery of water-insoluble apatinib, the drug was encapsulated in nanoparticles composed of human serum albumin (HSA)-conjugated polyethylene glycol (PEG). In vitro paracellular permeability and transendothelial electric resistance assays showed that apatinib-loaded HSA-PEG (Apa-HSA-PEG) nanoparticles significantly inhibited VEGF-induced endothelial hyperpermeability in human retinal microvascular endothelial cells. In addition, they substantially reduced the VEGF-induced junctional loss and internalization of vascular endothelial-cadherin, a major component of endothelial junction complexes. In vivo intravitreal injection of Apa-HSA-PEG nanoparticles in mice blocked VEGF-induced retinal vascular leakage. These in vitro and in vivo data indicated that Apa-HSA-PEG nanoparticles efficiently blocked VEGF-induced breakdown of the blood-retinal barrier. In vivo experiments with streptozotocin-induced diabetic mice showed that an intravitreal injection of Apa-HSA-PEG nanoparticles substantially inhibited diabetes-induced retinal vascular leakage. These results demonstrated, for the first time, that apatinib-loaded nanoparticles may be a promising therapeutic agent for the prevention and treatment of diabetes-induced retinal vascular disorders.

Therapeutic effect of apatinib-loaded nanoparticles on diabetes-induced retinal vascular leakage

PubMed Central

Jeong, Ji Hoon; Nguyen, Hong Khanh; Lee, Jung Eun; Suh, Wonhee

2016-01-01

Apatinib, a novel and selective inhibitor of vascular endothelial growth factor (VEGF) receptor 2, has been demonstrated recently to exhibit anticancer efficacy by inhibiting the VEGF signaling pathway. Given the importance of VEGF in retinal vascular leakage, the present study was designed to investigate whether apatinib-loaded polymeric nanoparticles inhibit VEGF-mediated retinal vascular hyperpermeability and block diabetes-induced retinal vascular leakage. For the delivery of water-insoluble apatinib, the drug was encapsulated in nanoparticles composed of human serum albumin (HSA)-conjugated polyethylene glycol (PEG). In vitro paracellular permeability and transendothelial electric resistance assays showed that apatinib-loaded HSA-PEG (Apa-HSA-PEG) nanoparticles significantly inhibited VEGF-induced endothelial hyperpermeability in human retinal microvascular endothelial cells. In addition, they substantially reduced the VEGF-induced junctional loss and internalization of vascular endothelial-cadherin, a major component of endothelial junction complexes. In vivo intravitreal injection of Apa-HSA-PEG nanoparticles in mice blocked VEGF-induced retinal vascular leakage. These in vitro and in vivo data indicated that Apa-HSA-PEG nanoparticles efficiently blocked VEGF-induced breakdown of the blood–retinal barrier. In vivo experiments with streptozotocin-induced diabetic mice showed that an intravitreal injection of Apa-HSA-PEG nanoparticles substantially inhibited diabetes-induced retinal vascular leakage. These results demonstrated, for the first time, that apatinib-loaded nanoparticles may be a promising therapeutic agent for the prevention and treatment of diabetes-induced retinal vascular disorders. PMID:27462154

Note: A novel method for in situ loading of gases via x-ray induced chemistry

NASA Astrophysics Data System (ADS)

Pravica, Michael; Bai, Ligang; Park, Changyong; Liu, Yu; Galley, Martin; Robinson, John; Bhattacharya, Neelanjan

2011-10-01

We have developed and demonstrated a novel method to load oxygen in a sealed diamond anvil cell via the x-ray induced decomposition of potassium chlorate. By irradiating a pressurized sample of an oxidizer (KClO3) with either monochromatic or white beam x-rays from the Advanced Photon Source at ambient temperature and variable pressure, we succeeded in creating a localized region of molecular oxygen surrounded by unreacted sample which was confirmed via Raman spectroscopy. We anticipate that this technique will be useful in loading even more challenging, difficult-to-load gases such as hydrogen and also to load multiple gases.

Note: A novel method for in situ loading of gases via x-ray induced chemistry.

PubMed

Pravica, Michael; Bai, Ligang; Park, Changyong; Liu, Yu; Galley, Martin; Robinson, John; Bhattacharya, Neelanjan

2011-10-01

We have developed and demonstrated a novel method to load oxygen in a sealed diamond anvil cell via the x-ray induced decomposition of potassium chlorate. By irradiating a pressurized sample of an oxidizer (KClO(3)) with either monochromatic or white beam x-rays from the Advanced Photon Source at ambient temperature and variable pressure, we succeeded in creating a localized region of molecular oxygen surrounded by unreacted sample which was confirmed via Raman spectroscopy. We anticipate that this technique will be useful in loading even more challenging, difficult-to-load gases such as hydrogen and also to load multiple gases.

Performance of Hydrophobisation Techniques in Case of Reinforced Concrete Structures

NASA Astrophysics Data System (ADS)

Błaszczyński, Tomasz; Osesek, Mateusz; Gwozdowski, Błażej; Ilski, Mirosław

2017-10-01

Concrete is, unchangeably, one of the most frequently applied building materials, also in the case of bridges, overpasses or viaducts. Along with the aging of such structures, the degradation of concrete, which may accelerate the corrosion of reinforcing steel and drastically decrease the load-bearing capacity of the structure, becomes an important issue. The paper analyzes the possibilities of using deep hydrophobisation in repairing reinforced concrete engineering structures. The benefits of properly securing reinforced concrete structures from the damaging effects of UV radiation, the influence of harmful gases, or progression of chlorine induced corrosion have been presented, especially in regards to bridge structures. The need to calculate the costs of carrying out investments along with the expected costs of maintaining such structures, as well as the high share of costs connected with logistics, has also been indicated in the total costs of repair works.

Flexible attention allocation to visual and auditory working memory tasks: manipulating reward induces a trade-off.

PubMed

Morey, Candice Coker; Cowan, Nelson; Morey, Richard D; Rouder, Jeffery N

2011-02-01

Prominent roles for general attention resources are posited in many models of working memory, but the manner in which these can be allocated differs between models or is not sufficiently specified. We varied the payoffs for correct responses in two temporally-overlapping recognition tasks, a visual array comparison task and a tone sequence comparison task. In the critical conditions, an increase in reward for one task corresponded to a decrease in reward for the concurrent task, but memory load remained constant. Our results show patterns of interference consistent with a trade-off between the tasks, suggesting that a shared resource can be flexibly divided, rather than only fully allotted to either of the tasks. Our findings support a role for a domain-general resource in models of working memory, and furthermore suggest that this resource is flexibly divisible.

Biomechanical implications of lumbar spinal ligament transection.

PubMed

Von Forell, Gregory A; Bowden, Anton E

2014-11-01

Many lumbar spine surgeries either intentionally or inadvertently damage or transect spinal ligaments. The purpose of this work was to quantify the previously unknown biomechanical consequences of isolated spinal ligament transection on the remaining spinal ligaments (stress transfer), vertebrae (bone remodelling stimulus) and intervertebral discs (disc pressure) of the lumbar spine. A finite element model of the full lumbar spine was developed and validated against experimental data and tested in the primary modes of spinal motion in the intact condition. Once a ligament was removed, stress increased in the remaining spinal ligaments and changes occurred in vertebral strain energy, but disc pressure remained similar. All major biomechanical changes occurred at the same spinal level as the transected ligament, with minor changes at adjacent levels. This work demonstrates that iatrogenic damage to spinal ligaments disturbs the load sharing within the spinal ligament network and may induce significant clinically relevant changes in the spinal motion segment.

Working memory load modulates the neural response to other's pain: Evidence from an ERP study.

PubMed

Cui, Fang; Zhu, Xiangru; Luo, Yuejia; Cheng, Jiaping

2017-03-22

The present study investigated the time course of processing other's pain under different conditions of working memory (WM) load. Event-related potentials (ERPs) were recorded while the participants held two digits (low WM load) or six digits (high WM load) in WM and viewed pictures that showed others who were in painful or non-painful situations. Robust WM-load×Picture interactions were found for the N2 and LPP components. In the high WM-load condition, painful pictures elicited significantly larger amplitudes than non-painful pictures. In the low WM load condition, the difference between the painful and non-painful pictures was not significant. These ERP results indicate that WM load can influence both the early automatic N2 component and late cognitive LPP component. Compared with high WM load, low WM load reduced affective arousal and emotional sharing in response to other's pain and weakened the cognitive evaluation of task irrelevant stimuli. These findings are explained from the load theory perspective. Copyright © 2017 Elsevier B.V. All rights reserved.

Advancing Lie Detection by Inducing Cognitive Load on Liars: A Review of Relevant Theories and Techniques Guided by Lessons from Polygraph-Based Approaches

PubMed Central

Walczyk, Jeffrey J.; Igou, Frank P.; Dixon, Alexa P.; Tcholakian, Talar

2013-01-01

This article critically reviews techniques and theories relevant to the emerging field of “lie detection by inducing cognitive load selectively on liars.” To help these techniques benefit from past mistakes, we start with a summary of the polygraph-based Controlled Question Technique (CQT) and the major criticisms of it made by the National Research Council (2003), including that it not based on a validated theory and administration procedures have not been standardized. Lessons from the more successful Guilty Knowledge Test are also considered. The critical review that follows starts with the presentation of models and theories offering insights for cognitive lie detection that can undergird theoretically load-inducing approaches. This is followed by evaluation of specific research-based, load-inducing proposals, especially for their susceptibility to rehearsal and other countermeasures. To help organize these proposals and suggest new direction for innovation and refinement, a theoretical taxonomy is presented based on the type of cognitive load induced in examinees (intrinsic or extraneous) and how open-ended the responses to test items are. Finally, four recommendations are proffered that can help researchers and practitioners to avert the corresponding mistakes with the CQT and yield new, valid cognitive lie detection technologies. PMID:23378840

Akt1 deficiency diminishes skeletal muscle hypertrophy by reducing satellite cell proliferation.

PubMed

Moriya, Nobuki; Miyazaki, Mitsunori

2018-05-01

Skeletal muscle mass is determined by the net dynamic balance between protein synthesis and degradation. Although the Akt/mechanistic target of rapamycin (mTOR)-dependent pathway plays an important role in promoting protein synthesis and subsequent skeletal muscle hypertrophy, the precise molecular regulation of mTOR activity by the upstream protein kinase Akt is largely unknown. In addition, the activation of satellite cells has been indicated as a key regulator of muscle mass. However, the requirement of satellite cells for load-induced skeletal muscle hypertrophy is still under intense debate. In this study, female germline Akt1 knockout (KO) mice were used to examine whether Akt1 deficiency attenuates load-induced skeletal muscle hypertrophy through suppressing mTOR-dependent signaling and satellite cell proliferation. Akt1 KO mice showed a blunted hypertrophic response of skeletal muscle, with a diminished rate of satellite cell proliferation following mechanical overload. In contrast, Akt1 deficiency did not affect the load-induced activation of mTOR signaling and the subsequent enhanced rate of protein synthesis in skeletal muscle. These observations suggest that the load-induced activation of mTOR signaling occurs independently of Akt1 regulation and that Akt1 plays a critical role in regulating satellite cell proliferation during load-induced muscle hypertrophy.

Characterizing the Response of Composite Panels to a Pyroshock Induced Environment Using Design of Experiments Methodology

NASA Technical Reports Server (NTRS)

Parsons, David S.; Ordway, David; Johnson, Kenneth

2013-01-01

This experimental study seeks to quantify the impact various composite parameters have on the structural response of a composite structure in a pyroshock environment. The prediction of an aerospace structure's response to pyroshock induced loading is largely dependent on empirical databases created from collections of development and flight test data. While there is significant structural response data due to pyroshock induced loading for metallic structures, there is much less data available for composite structures. One challenge of developing a composite pyroshock response database as well as empirical prediction methods for composite structures is the large number of parameters associated with composite materials. This experimental study uses data from a test series planned using design of experiments (DOE) methods. Statistical analysis methods are then used to identify which composite material parameters most greatly influence a flat composite panel's structural response to pyroshock induced loading. The parameters considered are panel thickness, type of ply, ply orientation, and pyroshock level induced into the panel. The results of this test will aid in future large scale testing by eliminating insignificant parameters as well as aid in the development of empirical scaling methods for composite structures' response to pyroshock induced loading.

Characterizing the Response of Composite Panels to a Pyroshock Induced Environment using Design of Experiments Methodology

NASA Technical Reports Server (NTRS)

Parsons, David S.; Ordway, David O.; Johnson, Kenneth L.

2013-01-01

This experimental study seeks to quantify the impact various composite parameters have on the structural response of a composite structure in a pyroshock environment. The prediction of an aerospace structure's response to pyroshock induced loading is largely dependent on empirical databases created from collections of development and flight test data. While there is significant structural response data due to pyroshock induced loading for metallic structures, there is much less data available for composite structures. One challenge of developing a composite pyroshock response database as well as empirical prediction methods for composite structures is the large number of parameters associated with composite materials. This experimental study uses data from a test series planned using design of experiments (DOE) methods. Statistical analysis methods are then used to identify which composite material parameters most greatly influence a flat composite panel's structural response to pyroshock induced loading. The parameters considered are panel thickness, type of ply, ply orientation, and pyroshock level induced into the panel. The results of this test will aid in future large scale testing by eliminating insignificant parameters as well as aid in the development of empirical scaling methods for composite structures' response to pyroshock induced loading.

Weight and volume variation in truckloads of logs hauled in the central Appalachians

Treesearch

Floyd G. Timson

1974-01-01

Variation in volume and weight was found among loaded log trucks even when such factors as truck type, logging job, and driver influence were eliminated. A load range of 10,000 pounds or 1,000 board feet was commonplace for the same truck, driver, and cutting site. Differences in log size, shape, weight, and species caused a major share of this variation. Yet,...

Design of an Input-Parallel Output-Parallel LLC Resonant DC-DC Converter System for DC Microgrids

NASA Astrophysics Data System (ADS)

Juan, Y. L.; Chen, T. R.; Chang, H. M.; Wei, S. E.

2017-11-01

Compared with the centralized power system, the distributed modularized power system is composed of several power modules with lower power capacity to provide a totally enough power capacity for the load demand. Therefore, the current stress of the power components in each module can then be reduced, and the flexibility of system setup is also enhanced. However, the parallel-connected power modules in the conventional system are usually controlled to equally share the power flow which would result in lower efficiency in low loading condition. In this study, a modular power conversion system for DC micro grid is developed with 48 V dc low voltage input and 380 V dc high voltage output. However, in the developed system control strategy, the numbers of power modules enabled to share the power flow is decided according to the output power at lower load demand. Finally, three 350 W power modules are constructed and parallel-connected to setup a modular power conversion system. From the experimental results, compared with the conventional system, the efficiency of the developed power system in the light loading condition is greatly improved. The modularized design of the power system can also decrease the power loss ratio to the system capacity.

Advanced gearbox technology

NASA Technical Reports Server (NTRS)

Anderson, N. E.; Cedoz, R. W.; Salama, E. E.; Wagner, D. A.

1987-01-01

An advanced 13,000 HP, counterrotating (CR) gearbox was designed and successfully tested to provide a technology base for future designs of geared propfan propulsion systems for both commercial and military aircraft. The advanced technology CR gearbox was designed for high efficiency, low weight, long life, and improved maintainability. The differential planetary CR gearbox features double helical gears, double row cylindrical roller bearings integral with planet gears, tapered roller prop support bearings, and a flexible ring gear and diaphragm to provide load sharing. A new Allison propfan back-to-back gearbox test facility was constructed. Extensive rotating and stationary instrumentation was used to measure temperature, strain, vibration, deflection and efficiency under representative flight operating conditions. The tests verified smooth, efficient gearbox operation. The highly-instrumented advanced CR gearbox was successfully tested to design speed and power (13,000 HP), and to a 115 percent overspeed condition. Measured CR gearbox efficiency was 99.3 percent at the design point based on heat loss to the oil. Tests demonstrated low vibration characteristics of double helical gearing, proper gear tooth load sharing, low stress levels, and the high load capacity of the prop tapered roller bearings. Applied external prop loads did not significantly affect gearbox temperature, vibration, or stress levels. Gearbox hardware was in excellent condition after the tests with no indication of distress.

Centaur Standard Shroud (CSS) static limit load structural tests

NASA Technical Reports Server (NTRS)

Eastwood, C.

1975-01-01

The structural capabilities of the jettisonable metal shroud were tested and the interaction of the shroud with the Centaur stage was evaluated. A flight-configured shroud and the assemblies of the associated Centaur stage were tested for applied axial and shear loads to flight limit values. The tests included various thermal, pressure, and load conditions to verify localized strength capabilities, to evaluate subsystem performance, and to determine the aging effect on insulation system properties. The tests series verified the strength capabilities of the shroud and of all associated flight assembles. Shroud deflections were shown to remain within allowable limits so long as load sharing members were connected between the shroud and the Centaur stage.

Control of thumb force using surface functional electrical stimulation and muscle load sharing

PubMed Central

2013-01-01

Background Stroke survivors often have difficulties in manipulating objects with their affected hand. Thumb control plays an important role in object manipulation. Surface functional electrical stimulation (FES) can assist movement. We aim to control the 2D thumb force by predicting the sum of individual muscle forces, described by a sigmoidal muscle recruitment curve and a single force direction. Methods Five able bodied subjects and five stroke subjects were strapped in a custom built setup. The forces perpendicular to the thumb in response to FES applied to three thumb muscles were measured. We evaluated the feasibility of using recruitment curve based force vector maps in predicting output forces. In addition, we developed a closed loop force controller. Load sharing between the three muscles was used to solve the redundancy problem having three actuators to control forces in two dimensions. The thumb force was controlled towards target forces of 0.5 N and 1.0 N in multiple directions within the individual’s thumb work space. Hereby, the possibilities to use these force vector maps and the load sharing approach in feed forward and feedback force control were explored. Results The force vector prediction of the obtained model had small RMS errors with respect to the actual measured force vectors (0.22±0.17 N for the healthy subjects; 0.17±0.13 N for the stroke subjects). The stroke subjects showed a limited work range due to limited force production of the individual muscles. Performance of feed forward control without feedback, was better in healthy subjects than in stroke subjects. However, when feedback control was added performances were similar between the two groups. Feedback force control lead, especially for the stroke subjects, to a reduction in stationary errors, which improved performance. Conclusions Thumb muscle responses to FES can be described by a single force direction and a sigmoidal recruitment curve. Force in desired direction can be generated through load sharing among redundant muscles. The force vector maps are subject specific and also suitable in feedforward and feedback control taking the individual’s available workspace into account. With feedback, more accurate control of muscle force can be achieved. PMID:24103414

Sonographic assessment of changes in diaphragmatic kinetics induced by inspiratory resistive loading.

PubMed

Soilemezi, Eleni; Tsagourias, Matthew; Talias, Michael A; Soteriades, Elpidoforos S; Makrakis, Vasilios; Zakynthinos, Epaminondas; Matamis, Dimitrios

2013-04-01

Diaphragmatic breathing patterns under resistive loading remain poorly documented. To our knowledge, this is the first study assessing diaphragmatic motion under conditions of inspiratory resistive loading with the use of sonography. We assessed diaphragmatic motion during inspiratory resistive loading in 40 healthy volunteers using M-mode sonography. In phase I of the study, sonography was performed during normal quiet breathing without respiratory loading. In phase II, sonography was performed after application of a nose clip and connection of the subjects to a pneumotachograph through a mouth piece. In phase III, the participants were assessed while subjected to inspiratory resistive loading of 50 cm H(2)O/L/s. Compared with baseline, the application of a mouth piece and nose clip induced a significant increase in diaphragmatic excursion (from 1.7 to 2.3 cm, P < 0.001) and a decrease in respiratory rate (from 13.4 to 12.2, P < 0.01). Inspiratory resistive loading induced a further decrease in respiratory rate (from 12.2 to 8.0, P < 0.01) and a decrease in diaphragmatic velocity contraction (from 1.2 to 0.8 cm/s, P < 0.01), and also an increase in tidal volume (from 795 to 904 mL, P < 0.01); diaphragmatic excursion, however, did not change significantly. Inspiratory resistive loading induced significant changes in diaphragmatic contraction pattern, which mainly consisted of decreased velocity of diaphragmatic displacement with no change in diaphragmatic excursion. Tidal volume, increased significantly; the increase in tidal volume, along with the unchanged diaphragmatic excursion, provides sonographic evidence of increased recruitment of extradiaphragmatic muscles under inspiratory resistive loading. © 2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology.

An improved sample loading technique for cellular metabolic response monitoring under pressure

NASA Astrophysics Data System (ADS)

Gikunda, Millicent Nkirote

To monitor cellular metabolism under pressure, a pressure chamber designed around a simple-to-construct capillary-based spectroscopic chamber coupled to a microliter-flow perfusion system is used in the laboratory. Although cyanide-induced metabolic responses from Saccharomyces cerevisiae (baker's yeast) could be controllably induced and monitored under pressure, previously used sample loading technique was not well controlled. An improved cell-loading technique which is based on use of a secondary inner capillary into which the sample is loaded then inserted into the capillary pressure chamber, has been developed. As validation, we demonstrate the ability to measure the chemically-induced metabolic responses at pressures of up to 500 bars. This technique is shown to be less prone to sample loss due to perfusive flow than the previous techniques used.

Optimization of scintillator loading with the tellurium-130 isotope for long-term stability

NASA Astrophysics Data System (ADS)

Duhamel, Lauren; Song, Xiaoya; Goutnik, Michael; Kaptanoglu, Tanner; Klein, Joshua; SNO+ Collaboration

2017-09-01

Tellurium-130 was selected as the isotope for the SNO + neutrinoless double beta decay search, as 130Te decays to 130Xe via double beta decay. Linear alkyl benzene(LAB) is the liquid scintillator for the SNO + experiment. To load tellurium into scintillator, it is combined with 1,2-butanediol to form an organometallic complex, commonly called tellurium butanediol (TeBD). This study focuses on maximizing the percentage of tellurium loaded into scintillator and evaluates the complex's long-term stability. Studies on the effect of nucleation due to imperfections in the detector's surface and external particulates were employed by filtration and induced nucleation. The impact of water on the stability of TeBD complex was evaluated by liquid-nitrogen sparging, variability in pH and induced humidity. Alternative loading methods were evaluated, including the addition of stability-inducing organic compounds. Samples of tellurium-loaded scintillator were synthesized, treated, and consistently monitored in a controlled environment. It was found that the hydronium ions cause precipitation in the loaded scintillator, demonstrating that water has a detrimental effect on long-term stability. Optimization of loaded scintillator stability can contribute to the SNO + double beta decay search.

myo-Inositol 1,4,5-trisphosphate and Ca(2+)/calmodulin-dependent factors mediate transduction of compression-induced signals in bovine articular chondrocytes.

PubMed Central

Valhmu, Wilmot B; Raia, Frank J

2002-01-01

Although the effects of mechanical loading on chondrocyte metabolic activities have been extensively characterized, the sequence of events through which extracellular mechanical signals are transduced into chondrocytes and ultimately modulate cell activities is not well understood. Here, studies were performed to map out the sequential intracellular signalling pathways through which compression-induced signals modulate aggrecan mRNA levels in bovine articular chondrocytes. Bovine articular cartilage explants were subjected to a compressive stress of 0.1 MPa for 1 h in the presence or absence of inhibitors or antagonists of the phosphoinositol and Ca(2+)/calmodulin signalling pathways in order to determine the roles of second messengers and effector molecules of these pathways in transducing the compression-induced signals. In the absence of the inhibitors, aggrecan mRNA levels were stimulated by compression 2-4-fold relative to levels in tare-loaded (see below) explants. Treatment of the explants with graded levels of the protein kinase C inhibitor chelerythrine or bisindolylmaleimide I, followed by 1 h compressive loading, did not significantly alter the load-induced elevation of aggrecan mRNA levels. In contrast, thapsigargin, which depletes the Ins(1,4,5)P3-sensitive intracellular Ca(2+) stores, completely blocked the load response without significantly altering aggrecan mRNA levels in tare-loaded explants. Similarly, antagonists of the Ca(2+)/calmodulin signalling pathway dose-dependently or completely blocked the load-response. The results obtained demonstrate that transduction of the compression-induced aggrecan mRNA-regulating signals requires Ins(1,4,5)P3- and Ca(2+)/calmodulin-dependent signalling processes in bovine articular chondrocytes. PMID:11802800

Global seasonal strain and stress models derived from GRACE loading, and their impact on seismicity

NASA Astrophysics Data System (ADS)

Chanard, K.; Fleitout, L.; Calais, E.; Craig, T. J.; Rebischung, P.; Avouac, J. P.

2017-12-01

Loading by continental water, atmosphere and oceans deforms the Earth at various spatio-temporal scales, inducing crustal and mantelic stress perturbations that may play a role in earthquake triggering.Deformation of the Earth by this surface loading is observed in GNSS position time series. While various models predict well vertical observations, explaining horizontal displacements remains challenging. We model the elastic deformation induced by loading derived from GRACE for coefficients 2 and higher. We estimate the degree-1 deformation field by comparison between predictions of our model and IGS-repro2 solutions at a globally distributed network of 700 GNSS sites, separating the horizontal and vertical components to avoid biases between components. The misfit between model and data is reduced compared to previous studies, particularly on the horizontal component. The associated geocenter motion time series are consistent with results derived from other datasets. We also discuss the impact on our results of systematic errors in GNSS geodetic products, in particular of the draconitic error.We then compute stress tensors time series induced by GRACE loads and discuss the potential link between large scale seasonal mass redistributions and seismicity. Within the crust, we estimate hydrologically induced stresses in the intraplate New Madrid Seismic Zone, where secular stressing rates are unmeasurably low. We show that a significant variation in the rate of micro-earthquakes at annual and multi-annual timescales coincides with stresses induced by hydrological loading in the upper Mississippi embayment, with no significant phase-lag, directly modulating regional seismicity. We also investigate pressure variations in the mantle transition zone and discuss potential correlations between the statistically significant observed seasonality of deep-focus earthquakes, most likely due to mineralogical transformations, and surface hydrological loading.

Voices of Women in the Field: Laundry and Leadership--A New Dance

ERIC Educational Resources Information Center

Curley, Ginny

2007-01-01

In this article, the author shares a story of a young couple who was arguing about the proper way to fold towels. The husband shared a story of how he had wanted to do something nice for his wife, who was studying. So he folded a load of towels and put them away. His wife then refolded the towels, explaining that he had folded them in half and…

Time-dependent fiber bundles with local load sharing. II. General Weibull fibers.

PubMed

Phoenix, S Leigh; Newman, William I

2009-12-01

Fiber bundle models (FBMs) are useful tools in understanding failure processes in a variety of material systems. While the fibers and load sharing assumptions are easily described, FBM analysis is typically difficult. Monte Carlo methods are also hampered by the severe computational demands of large bundle sizes, which overwhelm just as behavior relevant to real materials starts to emerge. For large size scales, interest continues in idealized FBMs that assume either equal load sharing (ELS) or local load sharing (LLS) among fibers, rules that reflect features of real load redistribution in elastic lattices. The present work focuses on a one-dimensional bundle of N fibers under LLS where life consumption in a fiber follows a power law in its load, with exponent rho , and integrated over time. This life consumption function is further embodied in a functional form resulting in a Weibull distribution for lifetime under constant fiber stress and with Weibull exponent, beta. Thus the failure rate of a fiber depends on its past load history, except for beta=1 . We develop asymptotic results validated by Monte Carlo simulation using a computational algorithm developed in our previous work [Phys. Rev. E 63, 021507 (2001)] that greatly increases the size, N , of treatable bundles (e.g., 10(6) fibers in 10(3) realizations). In particular, our algorithm is O(N ln N) in contrast with former algorithms which were O(N2) making this investigation possible. Regimes are found for (beta,rho) pairs that yield contrasting behavior for large N. For rho>1 and large N, brittle weakest volume behavior emerges in terms of characteristic elements (groupings of fibers) derived from critical cluster formation, and the lifetime eventually goes to zero as N-->infinity , unlike ELS, which yields a finite limiting mean. For 1/21 but with 0

Time-dependent fiber bundles with local load sharing. II. General Weibull fibers

NASA Astrophysics Data System (ADS)

Phoenix, S. Leigh; Newman, William I.

2009-12-01

Fiber bundle models (FBMs) are useful tools in understanding failure processes in a variety of material systems. While the fibers and load sharing assumptions are easily described, FBM analysis is typically difficult. Monte Carlo methods are also hampered by the severe computational demands of large bundle sizes, which overwhelm just as behavior relevant to real materials starts to emerge. For large size scales, interest continues in idealized FBMs that assume either equal load sharing (ELS) or local load sharing (LLS) among fibers, rules that reflect features of real load redistribution in elastic lattices. The present work focuses on a one-dimensional bundle of N fibers under LLS where life consumption in a fiber follows a power law in its load, with exponent ρ , and integrated over time. This life consumption function is further embodied in a functional form resulting in a Weibull distribution for lifetime under constant fiber stress and with Weibull exponent, β . Thus the failure rate of a fiber depends on its past load history, except for β=1 . We develop asymptotic results validated by Monte Carlo simulation using a computational algorithm developed in our previous work [Phys. Rev. EPLEEE81063-651X 63, 021507 (2001)] that greatly increases the size, N , of treatable bundles (e.g., 106 fibers in 103 realizations). In particular, our algorithm is O(NlnN) in contrast with former algorithms which were O(N2) making this investigation possible. Regimes are found for (β,ρ) pairs that yield contrasting behavior for large N . For ρ>1 and large N , brittle weakest volume behavior emerges in terms of characteristic elements (groupings of fibers) derived from critical cluster formation, and the lifetime eventually goes to zero as N→∞ , unlike ELS, which yields a finite limiting mean. For 1/2≤ρ≤1 , however, LLS has remarkably similar behavior to ELS (appearing to be virtually identical for ρ=1 ) with an asymptotic Gaussian lifetime distribution and a finite limiting mean for large N . The coefficient of variation follows a power law in increasing N but, except for ρ=1 , the value of the negative exponent is clearly less than 1/2 unlike in ELS bundles where the exponent remains 1/2 for 1/2<ρ≤1 . For sufficiently small values 0<ρ≪1 , a transition occurs, depending on β , whereby LLS bundle lifetimes become dominated by a few long-lived fibers. Thus the bundle lifetime appears to approximately follow an extreme-value distribution for the longest lived of a parallel group of independent elements, which applies exactly to ρ=0 . The lower the value of β , the higher the transition value of ρ , below which such extreme-value behavior occurs. No evidence was found for limiting Gaussian behavior for ρ>1 but with 0<β(ρ+1)<1 , as might be conjectured from quasistatic bundle models where β(ρ+1) mimics the Weibull exponent for fiber strength.

Design Evaluation of Wind Turbine Spline Couplings Using an Analytical Model: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guo, Y.; Keller, J.; Wallen, R.

2015-02-01

Articulated splines are commonly used in the planetary stage of wind turbine gearboxes for transmitting the driving torque and improving load sharing. Direct measurement of spline loads and performance is extremely challenging because of limited accessibility. This paper presents an analytical model for the analysis of articulated spline coupling designs. For a given torque and shaft misalignment, this analytical model quickly yields insights into relationships between the spline design parameters and resulting loads; bending, contact, and shear stresses; and safety factors considering various heat treatment methods. Comparisons of this analytical model against previously published computational approaches are also presented.

Evaluation of muscle activity for loaded and unloaded dynamic squats during vertical whole-body vibration.

PubMed

Hazell, Tom J; Kenno, Kenji A; Jakobi, Jennifer M

2010-07-01

The purpose of this investigation was to examine if the addition of a light external load would enhance whole-body vibration (WBV)-induced increases in muscle activity during dynamic squatting in 4 leg muscles. Thirteen recreationally active male university students performed a series of dynamic squats (unloaded with no WBV, unloaded with WBV, loaded with no WBV, and loaded with WBV). The load was set to 30% of body mass and WBV included 25-, 35-, and 45-Hz frequencies with 4-mm amplitude. Muscle activity was recorded with surface electromyography (EMG) on the vastus lateralis (VL), biceps femoris (BF), tibialis anterior (TA), and gastrocnemius (GC) and is reported as EMGrms (root mean square) normalized to %maximal voluntary exertion. During unloaded dynamic squats, exposure to WBV (45 Hz) significantly (p < 0.05) increased baseline muscle activity in all muscles, except the TA compared with no WBV. Adding a light external load without WBV increased baseline muscle activity of the squat exercise in all muscles but decreased the TA. This loaded level of muscle activity was further increased with WBV (45 Hz) in all muscles. The WBV-induced increases in muscle activity in the loaded condition (approximately 3.5%) were of a similar magnitude to the WBV-induced increases during the unloaded condition (approximately 2.5%) demonstrating the addition of WBV to unloaded or loaded dynamic squatting results in an increase in muscle activity. These results demonstrate the potential effectiveness of using external loads with exposure to WBV.

Shared and divergent pathways for flower abscission are triggered by gibberellic acid and carbon starvation in seedless Vitis vinifera L.

PubMed

Domingos, Sara; Fino, Joana; Cardoso, Vânia; Sánchez, Claudia; Ramalho, José C; Larcher, Roberto; Paulo, Octávio S; Oliveira, Cristina M; Goulao, Luis F

2016-02-01

Abscission is a highly coordinated developmental process by which plants control vegetative and reproductive organs load. Aiming at get new insights on flower abscission regulation, changes in the global transcriptome, metabolome and physiology were analyzed in 'Thompson Seedless' grapevine (Vitis vinifera L.) inflorescences, using gibberellic acid (GAc) spraying and shading as abscission stimuli, applied at bloom. Natural flower drop rates increased from 63.1% in non-treated vines to 83% and 99% in response to GAc and shade treatments, respectively. Both treatments had a broad effect on inflorescences metabolism. Specific impacts from shade included photosynthesis inhibition, associated nutritional stress, carbon/nitrogen imbalance and cell division repression, whereas GAc spraying induced energetic metabolism simultaneously with induction of nucleotide biosynthesis and carbon metabolism, therefore, disclosing alternative mechanisms to regulate abscission. Regarding secondary metabolism, changes in flavonoid metabolism were the most represented metabolic pathways in the samples collected following GAc treatment while phenylpropanoid and stilbenoid related pathways were predominantly affected in the inflorescences by the shade treatment. However, both GAc and shade treated inflorescences revealed also shared pathways, that involved the regulation of putrescine catabolism, the repression of gibberellin biosynthesis, the induction of auxin biosynthesis and the activation of ethylene signaling pathways and antioxidant mechanisms, although often the quantitative changes occurred on specific transcripts and metabolites of the pathways. Globally, the results suggest that chemical and environmental cues induced contrasting effects on inflorescence metabolism, triggering flower abscission by different mechanisms and pinpointing the participation of novel abscission regulators. Grapevine showed to be considered a valid model to study molecular pathways of flower abscission competence acquisition, noticeably responding to independent stimuli.

Why Are Drugs So Hard to Quit?

MedlinePlus

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Prediction-based dynamic load-sharing heuristics

NASA Technical Reports Server (NTRS)

Goswami, Kumar K.; Devarakonda, Murthy; Iyer, Ravishankar K.

1993-01-01

The authors present dynamic load-sharing heuristics that use predicted resource requirements of processes to manage workloads in a distributed system. A previously developed statistical pattern-recognition method is employed for resource prediction. While nonprediction-based heuristics depend on a rapidly changing system status, the new heuristics depend on slowly changing program resource usage patterns. Furthermore, prediction-based heuristics can be more effective since they use future requirements rather than just the current system state. Four prediction-based heuristics, two centralized and two distributed, are presented. Using trace driven simulations, they are compared against random scheduling and two effective nonprediction based heuristics. Results show that the prediction-based centralized heuristics achieve up to 30 percent better response times than the nonprediction centralized heuristic, and that the prediction-based distributed heuristics achieve up to 50 percent improvements relative to their nonprediction counterpart.

Flight Testing of the Capillary Pumped Loop 3 Experiment

NASA Technical Reports Server (NTRS)

Ottenstein, Laura; Butler, Dan; Ku, Jentung; Cheung, Kwok; Baldauff, Robert; Hoang, Triem

2002-01-01

The Capillary Pumped Loop 3 (CAPL 3) experiment was a multiple evaporator capillary pumped loop experiment that flew in the Space Shuttle payload bay in December 2001 (STS-108). The main objective of CAPL 3 was to demonstrate in micro-gravity a multiple evaporator capillary pumped loop system, capable of reliable start-up, reliable continuous operation, and heat load sharing, with hardware for a deployable radiator. Tests performed on orbit included start-ups, power cycles, low power tests (100 W total), high power tests (up to 1447 W total), heat load sharing, variable/fixed conductance transition tests, and saturation temperature change tests. The majority of the tests were completed successfully, although the experiment did exhibit an unexpected sensitivity to shuttle maneuvers. This paper describes the experiment, the tests performed during the mission, and the test results.

A Review of Distributed Control Techniques for Power Quality Improvement in Micro-grids

NASA Astrophysics Data System (ADS)

Zeeshan, Hafiz Muhammad Ali; Nisar, Fatima; Hassan, Ahmad

2017-05-01

Micro-grid is typically visualized as a small scale local power supply network dependent on distributed energy resources (DERs) that can operate simultaneously with grid as well as in standalone manner. The distributed generator of a micro-grid system is usually a converter-inverter type topology acting as a non-linear load, and injecting harmonics into the distribution feeder. Hence, the negative effects on power quality by the usage of distributed generation sources and components are clearly witnessed. In this paper, a review of distributed control approaches for power quality improvement is presented which encompasses harmonic compensation, loss mitigation and optimum power sharing in multi-source-load distributed power network. The decentralized subsystems for harmonic compensation and active-reactive power sharing accuracy have been analysed in detail. Results have been validated to be consistent with IEEE standards.

Audition and vision share spatial attentional resources, yet attentional load does not disrupt audiovisual integration.

PubMed

Wahn, Basil; König, Peter

2015-01-01

Humans continuously receive and integrate information from several sensory modalities. However, attentional resources limit the amount of information that can be processed. It is not yet clear how attentional resources and multisensory processing are interrelated. Specifically, the following questions arise: (1) Are there distinct spatial attentional resources for each sensory modality? and (2) Does attentional load affect multisensory integration? We investigated these questions using a dual task paradigm: participants performed two spatial tasks (a multiple object tracking task and a localization task), either separately (single task condition) or simultaneously (dual task condition). In the multiple object tracking task, participants visually tracked a small subset of several randomly moving objects. In the localization task, participants received either visual, auditory, or redundant visual and auditory location cues. In the dual task condition, we found a substantial decrease in participants' performance relative to the results of the single task condition. Importantly, participants performed equally well in the dual task condition regardless of the location cues' modality. This result suggests that having spatial information coming from different modalities does not facilitate performance, thereby indicating shared spatial attentional resources for the auditory and visual modality. Furthermore, we found that participants integrated redundant multisensory information similarly even when they experienced additional attentional load in the dual task condition. Overall, findings suggest that (1) visual and auditory spatial attentional resources are shared and that (2) audiovisual integration of spatial information occurs in an pre-attentive processing stage.

Precompetition taper and nutritional strategies: special reference to training during Ramadan intermittent fast.

PubMed

Mujika, Iñigo; Chaouachi, Anis; Chamari, Karim

2010-06-01

A marked reduction in the training load in the lead-up to major competitions allows athletes to reduce the fatigue induced by intense training and improve competition performance. This tapered training phase is based on the reduction in training volume while maintaining pretaper training intensity and frequency. In parallel to training load reductions, nutritional strategies characterised by lowered energy intakes need to be implemented to match lowered energy expenditure. The Ramadan intermittent fast imposes constrained nutritional practices on Muslim athletes, inducing a shift to a greater reliance on fat oxidation to meet energy needs and a possible increase in protein breakdown. The training load is often reduced during Ramadan to match the absence of energy and fluid intake during daylight, which implies a risk of losing training induced adaptations. Should coaches and athletes decide to reduce the training load during Ramadan, the key role of training intensity in retaining training induced adaptations should be kept in mind. However, experienced elite Muslim athletes are able to maintain their usual training load during this month of intermittent fasting without decrements in measures of fitness and with only minor adverse effects.

Neuroprotective effect of curcumin-loaded lactoferrin nano particles against rotenone induced neurotoxicity.

PubMed

Bollimpelli, V Satish; Kumar, Prashant; Kumari, Sonali; Kondapi, Anand K

2016-05-01

Curcumin is known to have neuroprotective role and possess antioxidant, anti-inflammatory activities. Rotenone, a flavonoid induced neurotoxicity in dopaminergic cells is being widely studied in Parkinson's Disease (PD) research. In the present study, curcumin loaded lactoferrin nano particles prepared by sol-oil chemistry were used to protect dopaminergic cell line SK-N-SH against rotenone induced neurotoxicity. These curcumin loaded nano particles were of 43-60 nm diameter size and around 100 nm hydrodynamic size as assessed by transmission electron microscopy, atomic force microscopy and dynamic light scattering analysis respectively. The encapsulation efficiency was 61.3% ± 2.4%. Cellular uptake of curcumin through these nano particles was confirmed by confocal imaging and spectrofluorimetric analysis. The curcumin loaded lactoferrin nanoparticles showed greater intracellular drug uptake, sustained retention and greater neuroprotection than soluble counterpart. Neuroprotective activity was characterized through viability assays and by estimating ROS levels. Furthermore rotenone induced PD like features were characterized by decrease in tyrosine hydroxylase expression and increase in α-synuclein expression. Taken together curcumin loaded lactoferrin nanoparticles could be a promising drug delivery strategy against neurotoxicity in dopaminergic neurons. Copyright © 2016 Elsevier Ltd. All rights reserved.

Visual short-term memory load suppresses temporo-parietal junction activity and induces inattentional blindness.

PubMed

Todd, J Jay; Fougnie, Daryl; Marois, René

2005-12-01

The right temporo-parietal junction (TPJ) is critical for stimulus-driven attention and visual awareness. Here we show that as the visual short-term memory (VSTM) load of a task increases, activity in this region is increasingly suppressed. Correspondingly, increasing VSTM load impairs the ability of subjects to consciously detect the presence of a novel, unexpected object in the visual field. These results not only demonstrate that VSTM load suppresses TPJ activity and induces inattentional blindness, but also offer a plausible neural mechanism for this perceptual deficit: suppression of the stimulus-driven attentional network.

Design Methodology for Bonded-Bolted Composite Joints. Volume I. Analysis Derivations and Illustrative Solutions

DTIC Science & Technology

1982-02-01

EXPERIMENTAL EVIDENCE ...... ....... ....... ....... ... 27 2.6 LOAD REDISTRIBUTION DUE TO DISBONDS IN ADHESIVE IN STEPPED-LAP JOINTS...SINGLE FASTENER " . ;39 3.4 LOAD SHARING BETWEEN MULTIRUW FASTENERS.."."..-.."." ൴ 3.5 FAILURE CRITERIA AT FASTENER HOLES . . ... 3.6 EXPERIMENTAL ...PLASTIC C. PERFECTLY ELASTIC THROUGHOUT A. ULL PLSTC SEAR TRS•WITHOUT $1IGN REVERSAL WITHOUT S:IG13 REVERSAL IOR FULLY NEGATIVE QUIVALENT ) (OR FULLY

Orbiter Gap Filler Bending Model for Re-entry

NASA Technical Reports Server (NTRS)

Campbell, Charles H.

2007-01-01

Pressure loads on a protruding gap filler during an Orbiter reentry are investigated to evaluate the likelihood of extraction due to pressure loads, and to ascertain how much bending will be induced by re-entry pressure loads. Oblique shock wave theory is utilized to develop a representation of the pressure loads induced on a gap filler for the ISSHVFW trajectory, representative of a heavy weight ISS return. A free body diagram is utilized to react the forces induced by the pressure forces. Preliminary results developed using these methods demonstrate that pressure loads, alone, are not likely causes of gap filler extraction during reentry. Assessment of the amount a gap filler will bend over is presented. Implications of gap filler bending during re-entry include possible mitigation of early boundary layer transition concerns, uncertainty in ground based measurement of protruding gap fillers from historical Orbiter flight history, and uncertainty in the use of Orbiter gap fillers for boundary layer prediction calibration. Authors will be added to the author list as appropriate.

33 CFR 222.4 - Reporting earthquake effects.

Code of Federal Regulations, 2012 CFR

2012-07-01

.... This indicates the possibility that earthquake induced loads may not have been adequately considered in... misalignment of hydraulic control structures or gates. Induced dynamic loading on earth dams may result in loss... area where the earthquake is felt but causes no or insignificant damage (Modified Mercalli Intensity VI...

33 CFR 222.4 - Reporting earthquake effects.

Code of Federal Regulations, 2013 CFR

2013-07-01

.... This indicates the possibility that earthquake induced loads may not have been adequately considered in... misalignment of hydraulic control structures or gates. Induced dynamic loading on earth dams may result in loss... area where the earthquake is felt but causes no or insignificant damage (Modified Mercalli Intensity VI...

Different roles of the medial and lateral hamstrings in unloading the anterior cruciate ligament.

PubMed

Guelich, David R; Xu, Dali; Koh, Jason L; Nuber, Gordon W; Zhang, Li-Qun

2016-01-01

Anterior cruciate ligament injuries are closely associated with excessive loading and motion about the off axes of the knee, i.e. tibial rotation and knee varus/valgus. However, it is not clear about the 3-D mechanical actions of the lateral and medial hamstring muscles and their differences in loading the ACL. The purpose of this study was to investigate the change in anterior cruciate ligament strain induced by loading the lateral and medial hamstrings individually. Seven cadaveric knees were investigated using a custom testing apparatus allowing for six degree-of-freedom tibiofemoral motion induced by individual muscle loading. With major muscles crossing the knee loaded moderately, the medial and lateral hamstrings were loaded independently to 200N along their lines of actions at 0°, 30°, 60° and 90° of knee flexion. The induced strain of the anterior cruciate ligament was measured using a differential variable reluctance transducer. Tibiofemoral kinematics was monitored using a six degrees-of-freedom knee goniometer. Loading the lateral hamstrings induced significantly more anterior cruciate ligament strain reduction (mean 0.764 [SD 0.63] %) than loading the medial hamstrings (mean 0.007 [0.2] %), (P=0.001 and effect size=0.837) across the knee flexion angles. The lateral and medial hamstrings have significantly different effects on anterior cruciate ligament loadings. More effective rehabilitation and training strategies may be developed to strengthen the lateral and medial hamstrings selectively and differentially to reduce anterior cruciate ligament injury and improve post-injury rehabilitation. The lateral and medial hamstrings can potentially be strengthened selectively and differentially as a more focused rehabilitation approach to reduce ACL injury and improve post-injury rehabilitation. Different ACL reconstruction procedures with some of them involving the medial hamstrings can be compared to each other for their effect on ACL loading. Copyright © 2015 Elsevier B.V. All rights reserved.

Hydrogen-Induced Plastic Deformation in ZnO

NASA Astrophysics Data System (ADS)

Lukáč, F.; Čížek, J.; Vlček, M.; Procházka, I.; Anwand, W.; Brauer, G.; Traeger, F.; Rogalla, D.; Becker, H.-W.

In the present work hydrothermally grown ZnO single crystals covered with Pd over-layer were electrochemically loaded with hydrogen and the influence of hydrogen on ZnO micro structure was investigated by positron annihilation spectroscopy (PAS). Nuclear reaction analysis (NRA) was employed for determination of depth profile of hydrogen concentration in the sample. NRA measurements confirmed that a substantial amount of hydrogen was introduced into ZnO by electrochemical charging. The bulk hydrogen concentration in ZnO determined by NRA agrees well with the concentration estimated from the transported charge using the Faraday's law. Moreover, a subsurface region with enhanced hydrogen concentration was found in the loaded crystals. Slow positron implantation spectroscopy (SPIS) investigations of hydrogen-loaded crystal revealed enhanced concentration of defects in the subsurface region. This testifies hydrogen-induced plastic deformation of the loaded crystal. Absorbed hydrogen causes a significant lattice expansion. At low hydrogen concentrations this expansion is accommodated by elastic straining, but at higher concentrations hydrogen-induced stress exceeds the yield stress in ZnO and plastic deformation of the loaded crystal takes place. Enhanced hydrogen concentration detected in the subsurface region by NRA is, therefore, due to excess hydrogen trapped at open volume defects introduced by plastic deformation. Moreover, it was found that hydrogen-induced plastic deformation in the subsurface layer leads to typical surface modification: formation of hexagonal shape pyramids on the surface due to hydrogen-induced slip in the [0001] direction.

Minimization theory of induced drag subject to constraint conditions

NASA Technical Reports Server (NTRS)

Deyoung, J.

1979-01-01

Exact analytical solutions in terms of induced drag influence coefficients can be attained which define the spanwise loading with minimized induced drag, subject to specified constraint conditions, for any nonplanar wing shape or number of lift plus wing bending moment about a given wing span station. Example applications of the theory are made to a biplane, a wing in ground effect, a cruciform wing, a V-wing, a planar-wing winglet, and linked wingtips in formation flying. For minimal induced drag, the spanwise loading, relative to elliptic, is outboard for the biplane and is inboard for the wing in ground effect and for the planar-wing winglet. A spinoff of the triplane solution provides mathematically exact equations for downwash and sidewash about a planar vorticity sheet having an arbitrary loading distribution.

Direct access inter-process shared memory

DOEpatents

Brightwell, Ronald B; Pedretti, Kevin; Hudson, Trammell B

2013-10-22

A technique for directly sharing physical memory between processes executing on processor cores is described. The technique includes loading a plurality of processes into the physical memory for execution on a corresponding plurality of processor cores sharing the physical memory. An address space is mapped to each of the processes by populating a first entry in a top level virtual address table for each of the processes. The address space of each of the processes is cross-mapped into each of the processes by populating one or more subsequent entries of the top level virtual address table with the first entry in the top level virtual address table from other processes.

Development of an optically-based tension-indicating implanted orthopedic screw with a luminescent spectral ruler

NASA Astrophysics Data System (ADS)

Ravikumar, Nakul; Rogalski, Melissa M.; Benza, Donny; Lake, Joshua; Urban, Matthew; Pelham, Hunter; Anker, Jeffrey N.; DesJardins, John D.

2017-03-01

An orthopaedic screw was designed with an optical tension-indicator to non-invasively quantify screw tension and monitor the load sharing between the bone and the implant. The screw both applies load to the bone, and measures this load by reporting the strain on the screw. The screw contains a colorimetric optical encoder that converts axial strain into colorimetric changes visible through the head of the screw, or luminescent spectral changes that are detected through tissue. Screws were tested under cyclic mechanical loading to mimic in-vivo conditions to verify the sensitivity, repeatability, and reproducibility of the sensor. In the absence to tissue, color was measured using a digital camera as a function of axial load on a stainless steel cannulated (hollow) orthopedic screw, modified by adding a passive colorimetric strain gauge through the central hole. The sensor was able to quantify clinically-relevant bone healing strains. The sensor exhibited good repeatability and reproducibility but also displayed hysteresis due to the internal mechanics of the screw. The strain indicator was also modified for measurement through tissue by replacing the reflective colorimetric sensor with a low-background X-ray excited optical luminescence signal. Luminescent spectra were acquired through 6 mm of chicken breast tissue. Overall, this research shows feasibility for a unique device which quantifies the strain on an orthopedic screw. Future research will involve reducing hysteresis by changing the mechanism of strain transduction in the screw, miniaturizing the luminescent strain gauge, monitoring bending as well as tension, using alternative luminescent spectral rulers based upon near infrared fluorescence or upconversion luminescence, and application to monitoring changes in pretension and load sharing during bone healing.

Load partitioning between the bcc-iron matrix and NiAl-type precipitates in a ferritic alloy on multiple length scales

PubMed Central

Sun, Zhiqian; Song, Gian; Sisneros, Thomas A.; Clausen, Bjørn; Pu, Chao; Li, Lin; Gao, Yanfei; Liaw, Peter K.

2016-01-01

An understanding of load sharing among constituent phases aids in designing mechanical properties of multiphase materials. Here we investigate load partitioning between the body-centered-cubic iron matrix and NiAl-type precipitates in a ferritic alloy during uniaxial tensile tests at 364 and 506 °C on multiple length scales by in situ neutron diffraction and crystal plasticity finite element modeling. Our findings show that the macroscopic load-transfer efficiency is not as high as that predicted by the Eshelby model; moreover, it depends on the matrix strain-hardening behavior. We explain the grain-level anisotropic load-partitioning behavior by considering the plastic anisotropy of the matrix and elastic anisotropy of precipitates. We further demonstrate that the partitioned load on NiAl-type precipitates relaxes at 506 °C, most likely through thermally-activated dislocation rearrangement on the microscopic scale. The study contributes to further understanding of load-partitioning characteristics in multiphase materials. PMID:26979660

Load partitioning between the bcc-iron matrix and NiAl-type precipitates in a ferritic alloy on multiple length scales

DOE PAGES

Sun, Zhiqian; Song, Gian; Sisneros, Thomas A.; ...

2016-03-16

An understanding of load sharing among constituent phases aids in designing mechanical properties of multiphase materials. Here we investigate load partitioning between the body-centered-cubic iron matrix and NiAl-type precipitates in a ferritic alloy during uniaxial tensile tests at 364 and 506 C on multiple length scales by in situ neutron diffraction and crystal plasticity finite element modeling. Our findings show that the macroscopic load-transfer efficiency is not as high as that predicted by the Eshelby model; moreover, it depends on the matrix strain-hardening behavior. We explain the grain-level anisotropic load-partitioning behavior by considering the plastic anisotropy of the matrix andmore » elastic anisotropy of precipitates. We further demonstrate that the partitioned load on NiAl-type precipitates relaxes at 506 C, most likely through thermally-activated dislocation rearrangement on the microscopic scale. Furthermore, the study contributes to further understanding of load-partitioning characteristics in multiphase materials.« less

Survival Model for Foot and Leg High Rate Axial Impact Injury Data.

PubMed

Bailey, Ann M; McMurry, Timothy L; Poplin, Gerald S; Salzar, Robert S; Crandall, Jeff R

2015-01-01

Understanding how lower extremity injuries from automotive intrusion and underbody blast (UBB) differ is of key importance when determining whether automotive injury criteria can be applied to blast rate scenarios. This article provides a review of existing injury risk analyses and outlines an approach to improve injury prediction for an expanded range of loading rates. This analysis will address issues with existing injury risk functions including inaccuracies due to inertial and potential viscous resistance at higher loading rates. This survival analysis attempts to minimize these errors by considering injury location statistics and a predictor variable selection process dependent upon failure mechanisms of bone. Distribution of foot/ankle/leg injuries induced by axial impact loading at rates characteristic of UBB as well as automotive intrusion was studied and calcaneus injuries were found to be the most common injury; thus, footplate force was chosen as the main predictor variable because of its proximity to injury location to prevent inaccuracies associated with inertial differences due to loading rate. A survival analysis was then performed with age, sex, dorsiflexion angle, and mass as covariates. This statistical analysis uses data from previous axial postmortem human surrogate (PMHS) component leg tests to provide perspectives on how proximal boundary conditions and loading rate affect injury probability in the foot/ankle/leg (n = 82). Tibia force-at-fracture proved to be up to 20% inaccurate in previous analyses because of viscous resistance and inertial effects within the data set used, suggesting that previous injury criteria are accurate only for specific rates of loading and boundary conditions. The statistical model presented in this article predicts 50% probability of injury for a plantar force of 10.2 kN for a 50th percentile male with a neutral ankle position. Force rate was found to be an insignificant covariate because of the limited range of loading rate differences within the data set; however, compensation for inertial effects caused by measuring the force-at-fracture in a location closer to expected injury location improved the model's predictive capabilities for the entire data set. This study provides better injury prediction capabilities for both automotive and blast rates because of reduced sensitivity to inertial effects and tibia-fibula load sharing. Further, a framework is provided for future injury criteria generation for high rate loading scenarios. This analysis also suggests key improvements to be made to existing anthropomorphic test device (ATD) lower extremities to provide accurate injury prediction for high rate applications such as UBB.

Mobile User Objective System (MUOS) Multi-Service Operational Test and Evaluation-2 Report (with Classified Annex)

DTIC Science & Technology

2016-06-01

an effective system monitoring and display capability. The SOM, C-SSE, and resource managers access MUOS via a web portal called the MUOS Planning...and Provisioning Application (PlanProvApp). This web portal is their window into MUOS and is designed to provide them with a shared understanding of...including page loading errors, partially loaded web pages, incomplete reports, and inaccurate reports. For example, MUOS reported that there were

FEMCAM Analysis of SULTAN Test Results for ITER Nb3SN Cable-conduit Conductors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yuhu Zhai, Pierluigi Bruzzone, Ciro Calzolaio

2013-03-19

Performance degradation due to filament fracture of Nb3 Sn cable-in-conduit conductors (CICCs) is a critical issue in large-scale magnet designs such as ITER which is currently being constructed in the South of France. The critical current observed in most SULTAN TF CICC samples is significantly lower than expected and the voltage-current characteristic is seen to have a much broader transition from a single strand to the CICC. Moreover, most conductors exhibit the irreversible degradation due to filament fracture and strain relaxation under electromagnetic cyclic loading. With recent success in monitoring thermal strain distribution and its evolution under the electromagnetic cyclicmore » loading from in situ measurement of critical temperature, we apply FEMCAM which includes strand filament breakage and local current sharing effects to SULTAN tested CICCs to study Nb3 Sn strain sensitivity and irreversible performance degradation. FEMCAM combines the thermal bending effect during cool down and the EM bending effect due to locally accumulating Lorentz force during magnet operation. It also includes strand filament fracture and related local current sharing for the calculation of cable n value. In this paper, we model continuous performance degradation under EM cyclic loading based on strain relaxation and the transition broadening upon cyclic loading to the extreme cases seen in SULTAN test data to better quantify conductor performance degradation.« less

The effect of dentinal fluid flow during loading in various directions--simulation of fluid-structure interaction.

PubMed

Su, Kuo-Chih; Chang, Chih-Han; Chuang, Shu-Fen; Ng, Eddie Yin-Kwee

2013-06-01

This study uses a fluid-structure interaction (FSI) simulation to evaluate the fluid flow in a dental intrapulpal chamber induced by the deformation of the tooth structure during loading in various directions. The FSI is used for the biomechanics simulation of dental intrapulpal responses with the force loading gradually increasing from 0 to 100N at 0°, 30°, 45°, 60°, and 90° on the tooth surface in 1s, respectively. The effect of stress or deformation on tooth and fluid flow changes in the pulp chamber are evaluated. A horizontal loading force on a tooth may induce tooth structure deformation, which increases fluid flow velocity in the coronal pulp. Thus, horizontal loading on a tooth may easily induce tooth pain. This study suggests that experiments to investigate the relationship between loading in various directions and dental pain should avoid measuring the bulk pulpal fluid flow from radicular pulp, but rather should measure the dentinal fluid flow in the dentinal tubules or coronal pulp. The FSI analysis used here could provide a powerful tool for investigating problems with coupled solid and fluid structures in dental biomechanics. Copyright © 2012 Elsevier Ltd. All rights reserved.

Fracture control method for composite tanks with load sharing liners

NASA Technical Reports Server (NTRS)

Bixler, W. D.

1975-01-01

The experimental program was based on the premise that the plastic sizing cycle, which each pressure vessel is subjected to prior to operation, acts as an effective proof test of the liner, screening out all flaws or cracks larger than a critical size. In doing so, flaw growth potential is available for cyclic operation at pressures less than the sizing pressure. Static fracture and cyclic life tests, involving laboratory type specimens and filament overwrapped tanks, were conducted on three liner materials: (1) 2219-T62 aluminum, (2) Inconel X750 STA, and (3) cryoformed 301 stainless steel. Variables included material condition, thickness, flaw size, flaw shape, temperature, sizing stress level, operating stress level and minimum-to-maximum operating stress ratio. From the empirical data base obtained, a procedure was established by which the service life of composite tanks with load sharing liners could be guaranteed with a high degree of confidence.

A Numerical Solution Routine for Investigating Oxidation-Induced Strength Degradation Mechanisms in SiC/SiC Composites

NASA Technical Reports Server (NTRS)

Sullivan, Roy M.

2015-01-01

The stress rupture strength of silicon carbide fiber-reinforced silicon carbide (SiCSiC) composites with a boron nitride (BN) fiber coating decreases with time within the intermediate temperature range of 700-950 C. Various theories have been proposed to explain the cause of the time dependent stress rupture strength. Some previous authors have suggested that the observed composite strength behavior is due to the inherent time dependent strength of the fibers, which is caused by the slow growth of flaws within the fibers. Flaw growth is supposedly enabled by oxidation of free carbon at the grain boundaries. The objective of this paper is to investigate the relative significance of the various theories for the time-dependent strength of SiCSiC composites. This is achieved through the development of a numerically-based progressive failure analysis routine and through the application of the routine to simulate the composite stress rupture tests. The progressive failure routine is a time marching routine with an iterative loop between a probability of fiber survival equation and a force equilibrium equation within each time step. Failure of the composite is assumed to initiate near a matrix crack and the progression of fiber failures occurs by global load sharing. The probability of survival equation is derived from consideration of the strength of ceramic fibers with randomly occurring and slow growing flaws as well as the mechanical interaction between the fibers and matrix near a matrix crack. The force equilibrium equation follows from the global load sharing presumption. The results of progressive failure analyses of the composite tests suggest that the relationship between time and stress-rupture strength is attributed almost entirely to the slow flaw growth within the fibers. Although other mechanisms may be present, they appear to have only a minor influence on the observed time dependent behavior.

Evaluation of a stall-flutter spring-damper pushrod in the rotating control system of a CH-54B helicopter

NASA Technical Reports Server (NTRS)

Nettles, W. E.; Paul, W. F.; Adams, D. O.

1974-01-01

Results of a design and flight test program conducted to define the effect of rotating pushrod damping on stall-flutter induced control loads are presented. The CH-54B helicopter was chosen as the test aircraft because it exhibited stall induced control loads. Damping was introduced into the CH-54B control system by replacing the standard pushrod with spring-damper assemblies. Design features of the spring-damper are described and the results of a dynamic analysis are shown which define the pushrod stiffness and damping requirements. Flight test measurements taken at 47,000 lb gross weight with and without the damper are presented. The results indicate that the spring-damper pushrods reduced high frequency, stall-induced rotating control loads by almost 50%. Fixed system control loads were reduced by 40%. Handling qualities in stall were unchanged, as expected.

Tug of war of molecular motors: the effects of uneven load sharing

NASA Astrophysics Data System (ADS)

Bouzat, Sebastián; Falo, Fernando

2011-12-01

We analyze theoretically the problem of cargo transport along microtubules by motors of two species with opposite polarities. We consider two different one-dimensional models previously developed in the literature: a quite widespread model which assumes equal force sharing, here referred to as the mean field model (MFM), and a stochastic model (SM) which considers individual motor-cargo links. We find that in generic situations, the MFM predicts larger cargo mean velocity, smaller mean run time and less frequent reversions than the SM. These phenomena are found to be the consequences of the load sharing assumptions and can be interpreted in terms of the probabilities of the different motility states. We also explore the influence of the viscosity in both models and the role of the stiffness of the motor-cargo links within the SM. Our results show that the mean cargo velocity is independent of the stiffness, while the mean run time decreases with such a parameter. We explore the case of symmetric forward and backward motors considering kinesin-1 parameters, and the problem of transport by kinesin-1 and cytoplasmic dyneins considering two different sets of parameters previously proposed for dyneins.

Method for prefetching non-contiguous data structures

DOEpatents

Blumrich, Matthias A [Ridgefield, CT; Chen, Dong [Croton On Hudson, NY; Coteus, Paul W [Yorktown Heights, NY; Gara, Alan G [Mount Kisco, NY; Giampapa, Mark E [Irvington, NY; Heidelberger, Philip [Cortlandt Manor, NY; Hoenicke, Dirk [Ossining, NY; Ohmacht, Martin [Brewster, NY; Steinmacher-Burow, Burkhard D [Mount Kisco, NY; Takken, Todd E [Mount Kisco, NY; Vranas, Pavlos M [Bedford Hills, NY

2009-05-05

A low latency memory system access is provided in association with a weakly-ordered multiprocessor system. Each processor in the multiprocessor shares resources, and each shared resource has an associated lock within a locking device that provides support for synchronization between the multiple processors in the multiprocessor and the orderly sharing of the resources. A processor only has permission to access a resource when it owns the lock associated with that resource, and an attempt by a processor to own a lock requires only a single load operation, rather than a traditional atomic load followed by store, such that the processor only performs a read operation and the hardware locking device performs a subsequent write operation rather than the processor. A simple perfecting for non-contiguous data structures is also disclosed. A memory line is redefined so that in addition to the normal physical memory data, every line includes a pointer that is large enough to point to any other line in the memory, wherein the pointers to determine which memory line to prefect rather than some other predictive algorithm. This enables hardware to effectively prefect memory access patterns that are non-contiguous, but repetitive.

Low latency memory access and synchronization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blumrich, Matthias A.; Chen, Dong; Coteus, Paul W.

A low latency memory system access is provided in association with a weakly-ordered multiprocessor system. Each processor in the multiprocessor shares resources, and each shared resource has an associated lock within a locking device that provides support for synchronization between the multiple processors in the multiprocessor and the orderly sharing of the resources. A processor only has permission to access a resource when it owns the lock associated with that resource, and an attempt by a processor to own a lock requires only a single load operation, rather than a traditional atomic load followed by store, such that the processormore » only performs a read operation and the hardware locking device performs a subsequent write operation rather than the processor. A simple prefetching for non-contiguous data structures is also disclosed. A memory line is redefined so that in addition to the normal physical memory data, every line includes a pointer that is large enough to point to any other line in the memory, wherein the pointers to determine which memory line to prefetch rather than some other predictive algorithm. This enables hardware to effectively prefetch memory access patterns that are non-contiguous, but repetitive.« less

Low latency memory access and synchronization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blumrich, Matthias A.; Chen, Dong; Coteus, Paul W.

A low latency memory system access is provided in association with a weakly-ordered multiprocessor system. Bach processor in the multiprocessor shares resources, and each shared resource has an associated lock within a locking device that provides support for synchronization between the multiple processors in the multiprocessor and the orderly sharing of the resources. A processor only has permission to access a resource when it owns the lock associated with that resource, and an attempt by a processor to own a lock requires only a single load operation, rather than a traditional atomic load followed by store, such that the processormore » only performs a read operation and the hardware locking device performs a subsequent write operation rather than the processor. A simple prefetching for non-contiguous data structures is also disclosed. A memory line is redefined so that in addition to the normal physical memory data, every line includes a pointer that is large enough to point to any other line in the memory, wherein the pointers to determine which memory line to prefetch rather than some other predictive algorithm. This enables hardware to effectively prefetch memory access patterns that are non-contiguous, but repetitive.« less

Solar powered actuator with continuously variable auxiliary power control

NASA Technical Reports Server (NTRS)

Nola, F. J. (Inventor)

1984-01-01

A solar powered system is disclosed in which a load such as a compressor is driven by a main induction motor powered by a solar array. An auxiliary motor shares the load with the solar powered motor in proportion to the amount of sunlight available, is provided with a power factor controller for controlling voltage applied to the auxiliary motor in accordance with the loading on that motor. In one embodiment, when sufficient power is available from the solar cell, the auxiliary motor is driven as a generator by excess power from the main motor so as to return electrical energy to the power company utility lines.

Biomechanical validation of load-sharing rip-stop fixation for the repair of tissue-deficient rotator cuff tears.

PubMed

Burkhart, Stephen S; Denard, Patrick J; Konicek, John; Hanypsiak, Bryan T

2014-02-01

Poor-quality tendon is one of the most difficult problems the surgeon must overcome in achieving secure fixation during rotator cuff repair. A load-sharing rip-stop construct (LSRS) has recently been proposed as a method for improving fixation strength, but the biomechanical properties of this construct have not yet been examined. To compare the strength of the LSRS construct to that of single-row fixation for rotator cuff repair. Controlled laboratory study. Rotator cuff tears were created in 6 cadaveric matched-pair specimens and repaired with a single row or an LSRS. In the LSRS repair, a 2-mm suture tape was placed as an inverted mattress stitch in the rotator cuff, and sutures from 2 anchors were placed as simple stitches that passed medial to the suture tape. The suture tape limbs were secured with knotless anchors laterally before sutures were tied from the medial anchors. Displacement was observed with video tracking after cyclic loading, and specimens were loaded to failure. The mean load to failure was 371 ± 102 N in single-row repairs compared with 616 ± 185 N in LSRS repairs (P = .031). There was no difference in displacement with cyclic loading between the groups (3.3 ± 0.8 mm vs. 3.5 ± 1.1 mm; P = .561). In the single-row group, 4 of 6 failures occurred at the suture-tendon interface. In the LSRS group, only 1 failure occurred at the suture-tendon interface. The ultimate failure load of the LSRS construct for rotator cuff repair was 1.7 times that of a single-row construct in a cadaveric model. The LSRS rotator cuff repair construct may be useful in the repair of difficult tears such as massive tears, medial tears, and tears with tendon loss.

A short pulse of mechanical force induces gene expression and growth in MC3T3-E1 osteoblasts via an ERK 1/2 pathway

NASA Technical Reports Server (NTRS)

Hatton, Jason P.; Pooran, Milad; Li, Chai-Fei; Luzzio, Chris; Hughes-Fulford, Millie

2003-01-01

Physiological mechanical loading is crucial for maintenance of bone integrity and architecture. We have calculated the strain caused by gravity stress on osteoblasts and found that 4-30g corresponds to physiological levels of 40-300 microstrain. Short-term gravity loading (15 minutes) induced a 15-fold increase in expression of growth-related immediate early gene c-fos, a 5-fold increase in egr-1, and a 3-fold increase in autocrine bFGF. The non-growth-related genes EP-1, TGF-beta, and 18s were unaffected by gravity loading. Short-term physiological loading induced extracellular signal-regulated kinase (ERK 1/2) phosphorylation in a dose-dependent manner with maximum phosphorylation saturating at mechanical loading levels of 12g (p < 0.001) with no effect on total ERK. The phosphorylation of focal adhesion kinase (FAK) was unaffected by mechanical force. g-Loading did not activate P38 MAPK or c-jun N-terminal kinase (JNK). Additionally, a gravity pulse resulted in the localization of phosphorylated ERK 1/2 to the nucleus; this did not occur in unloaded cells. The induction of c-fos was inhibited 74% by the MEK1/2 inhibitor U0126 (p < 0.001) but was not affected by MEK1 or p38 MAPK-specific inhibitors. The long-term consequence of a single 15-minute gravity pulse was a 64% increase in cell growth (p < 0.001). U0126 significantly inhibited gravity-induced growth by 50% (p < 0.001). These studies suggest that short periods of physiological mechanical stress induce immediate early gene expression and growth in MC3T3-E1 osteoblasts primarily through an ERK 1/2-mediated pathway.

Dynamics of a split torque helicopter transmission

NASA Astrophysics Data System (ADS)

Krantz, Timothy L.

1994-06-01

Split torque designs, proposed as alternatives to traditional planetary designs for helicopter main rotor transmissions, can save weight and be more reliable than traditional designs. This report presents the results of an analytical study of the system dynamics and performance of a split torque gearbox that uses a balance beam mechanism for load sharing. The Lagrange method was applied to develop a system of equations of motion. The mathematical model includes time-varying gear mesh stiffness, friction, and manufacturing errors. Cornell's method for calculating the stiffness of spur gear teeth was extended and applied to helical gears. The phenomenon of sidebands spaced at shaft frequencies about gear mesh fundamental frequencies was simulated by modeling total composite gear errors as sinusoid functions. Although the gearbox has symmetric geometry, the loads and motions of the two power paths differ. Friction must be considered to properly evaluate the balance beam mechanism. For the design studied, the balance beam is not an effective device for load sharing unless the coefficient of friction is less than 0.003. The complete system stiffness as represented by the stiffness matrix used in this analysis must be considered to precisely determine the optimal tooth indexing position.

Dynamics of a split torque helicopter transmission. M.S. Thesis - Cleveland State Univ.

NASA Technical Reports Server (NTRS)

Krantz, Timothy L.

1994-01-01

Split torque designs, proposed as alternatives to traditional planetary designs for helicopter main rotor transmissions, can save weight and be more reliable than traditional designs. This report presents the results of an analytical study of the system dynamics and performance of a split torque gearbox that uses a balance beam mechanism for load sharing. The Lagrange method was applied to develop a system of equations of motion. The mathematical model includes time-varying gear mesh stiffness, friction, and manufacturing errors. Cornell's method for calculating the stiffness of spur gear teeth was extended and applied to helical gears. The phenomenon of sidebands spaced at shaft frequencies about gear mesh fundamental frequencies was simulated by modeling total composite gear errors as sinusoid functions. Although the gearbox has symmetric geometry, the loads and motions of the two power paths differ. Friction must be considered to properly evaluate the balance beam mechanism. For the design studied, the balance beam is not an effective device for load sharing unless the coefficient of friction is less than 0.003. The complete system stiffness as represented by the stiffness matrix used in this analysis must be considered to precisely determine the optimal tooth indexing position.

On Proportionate and Truthful International Alliance Contributions: An Analysis of IncentiveCompatible Cost Sharing Mechanisms to Burden Sharing

DTIC Science & Technology

2017-03-23

Therefore, the mecha- nism induces a stable cost sharing scheme wherein a subset of colluding players will not all benefit . In a subset of colluding...goods are not divisible and are not excludable. Cost sharing mechanisms specific to public goods have been researched extensively in the literature...Jackson & Moulin [1992] consider the sharing of cost for an indivisible public project among many players, and their work was extended by Bag [1997] to

Reliable file sharing in distributed operating system using web RTC

NASA Astrophysics Data System (ADS)

Dukiya, Rajesh

2017-12-01

Since, the evolution of distributed operating system, distributed file system is come out to be important part in operating system. P2P is a reliable way in Distributed Operating System for file sharing. It was introduced in 1999, later it became a high research interest topic. Peer to Peer network is a type of network, where peers share network workload and other load related tasks. A P2P network can be a period of time connection, where a bunch of computers connected by a USB (Universal Serial Bus) port to transfer or enable disk sharing i.e. file sharing. Currently P2P requires special network that should be designed in P2P way. Nowadays, there is a big influence of browsers in our life. In this project we are going to study of file sharing mechanism in distributed operating system in web browsers, where we will try to find performance bottlenecks which our research will going to be an improvement in file sharing by performance and scalability in distributed file systems. Additionally, we will discuss the scope of Web Torrent file sharing and free-riding in peer to peer networks.

Protective effects of alginate–chitosan microspheres loaded with alkaloids from Coptis chinensis Franch. and Evodia rutaecarpa (Juss.) Benth. (Zuojin Pill) against ethanol-induced acute gastric mucosal injury in rats

PubMed Central

Wang, Qiang-Song; Zhu, Xiao-Ning; Jiang, Heng-Li; Wang, Gui-Fang; Cui, Yuan-Lu

2015-01-01

Zuojin Pill (ZJP), a traditional Chinese medicine formula, consists of Coptis chinensis Franch. and Evodia rutaecarpa (Juss.) Benth. in a ratio of 6:1 (w/w) and was first recorded in “Danxi’s experiential therapy” for treating gastrointestinal disorders in the 15th century. However, the poor solubility of alkaloids from ZJP restricted the protective effect in treating gastritis and gastric ulcer. The aim of the study was to investigate the protective mechanism of mucoadhesive microspheres loaded with alkaloids from C. chinensis Franch. and E. rutaecarpa (Juss.) Benth. on ethanol-induced acute gastric mucosal injury in rats. Surface morphology, particle size, drug loading, encapsulation efficiency, in vitro drug release, mucoadhesiveness, and fluorescent imaging of the microspheres in gastrointestinal tract were studied. The results showed that the mucoadhesive microspheres loaded with alkaloids could sustain the release of drugs beyond 12 hours and had gastric mucoadhesive property with 82.63% retention rate in vitro. The fluorescence tracer indicated high retention of mucoadhesive microspheres within 12 hours in vivo. The mucoadhesive microspheres loaded with alkaloids could reduce the gastric injury by decreasing the mucosal lesion index, increasing the percentage of inhibition and increasing the amount of mucus in the gastric mucosa in an ethanol-induced gastric mucosal injury rat model. Moreover, the mucoadhesive microspheres loaded with alkaloids reduce the inflammatory response by decreasing the levels of tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β), downregulating the mRNA expression of inducible nitric oxide synthase, TNF-α, and IL-1β in gastric mucosa. All the results indicate that mucoadhesive microspheres loaded with alkaloids could not only increase the residence time of alkaloids in rat stomach, but also exert gastroprotective effects through reducing the inflammatory response on ethanol-induced gastric mucosal damage. Thus, these microspheres could be developed as a potential controlled release drug for treatment of gastric ulcer. PMID:26640368

Further study on the wheel-rail impact response induced by a single wheel flat: the coupling effect of strain rate and thermal stress

NASA Astrophysics Data System (ADS)

Jing, Lin; Han, Liangliang

2017-12-01

A comprehensive dynamic finite-element simulation method was proposed to study the wheel-rail impact response induced by a single wheel flat based on a 3-D rolling contact model, where the influences of the structural inertia, strain rate effect of wheel-rail materials and thermal stress due to the wheel-rail sliding friction were considered. Four different initial conditions (i.e. pure mechanical loading plus rate-independent, pure mechanical loading plus rate-dependent, thermo-mechanical loading plus rate-independent, and thermo-mechanical loading plus rate-dependent) were involved into explore the corresponding impact responses in term of the vertical impact force, von-Mises equivalent stress, equivalent plastic strain and shear stress. Influences of train speed, flat length and axle load on the flat-induced wheel-rail impact response were discussed, respectively. The results indicate that the maximum thermal stresses are occurred on the tread of the wheel and on the top surface of the middle rail; the strain rate hardening effect contributes to elevate the von-Mises equivalent stress and restrain the plastic deformation; and the initial thermal stress due to the sliding friction will aggravate the plastic deformation of wheel and rail. Besides, the wheel-rail impact responses (i.e. impact force, von-Mises equivalent stress, equivalent plastic strain, and XY shear stress) induced by a flat are sensitive to the train speed, flat length and axle load.

Load sharing in the growth of bundled biopolymers

PubMed Central

Wang, Ruizhe; Carlsson, A. E.

2014-01-01

To elucidate the nature of load sharing in the growth of multiple biopolymers, we perform stochastic simulations of the growth of biopolymer bundles against obstacles under a broad range of conditions and varying assumptions. The obstacle motion due to thermal fluctuations is treated explicitly. We assume the “Perfect Brownian Ratchet” (PBR) model, in which the polymerization rate equals the free-filament rate as soon as the filament-obstacle distance exceeds the monomer size. Accurate closed-form formulas are obtained for the case of a rapidly moving obstacle. We find the following: (1) load sharing is usually sub-perfect in the sense that polymerization is slower than for a single filament carrying the same average force; (2) the sub-perfect behavior becomes significant at a total force proportional to the logarithm or the square root of the number of filaments, depending on the alignment of the filaments; (3) for the special case of slow barrier diffusion and low opposing force, an enhanced obstacle velocity for an increasing number of filaments is possible; (4) the obstacle velocity is very sensitive to the alignment of the filaments in the bundle, with a staggered alignment being an order of magnitude faster than an unstaggered one at forces of only 0.5 pN per filament for 20 filaments; (5) for large numbers of filaments, the power is maximized at a force well below 1 pN per filament; (6) for intermediate values of the obstacle diffusion coefficient, the shape of the force velocity relation is very similar to that for rapid obstacle diffusion. PMID:25489273

Load sharing in the growth of bundled biopolymers.

PubMed

Wang, Ruizhe; Carlsson, A E

2014-11-01

To elucidate the nature of load sharing in the growth of multiple biopolymers, we perform stochastic simulations of the growth of biopolymer bundles against obstacles under a broad range of conditions and varying assumptions. The obstacle motion due to thermal fluctuations is treated explicitly. We assume the "Perfect Brownian Ratchet" (PBR) model, in which the polymerization rate equals the free-filament rate as soon as the filament-obstacle distance exceeds the monomer size. Accurate closed-form formulas are obtained for the case of a rapidly moving obstacle. We find the following: (1) load sharing is usually sub-perfect in the sense that polymerization is slower than for a single filament carrying the same average force; (2) the sub-perfect behavior becomes significant at a total force proportional to the logarithm or the square root of the number of filaments, depending on the alignment of the filaments; (3) for the special case of slow barrier diffusion and low opposing force, an enhanced obstacle velocity for an increasing number of filaments is possible; (4) the obstacle velocity is very sensitive to the alignment of the filaments in the bundle, with a staggered alignment being an order of magnitude faster than an unstaggered one at forces of only 0.5 pN per filament for 20 filaments; (5) for large numbers of filaments, the power is maximized at a force well below 1 pN per filament; (6) for intermediate values of the obstacle diffusion coefficient, the shape of the force velocity relation is very similar to that for rapid obstacle diffusion.

Thermal Vacuum Testing of a Proto-flight Miniature Loop Heat Pipe with Two Evaporators and Two Condensers

NASA Technical Reports Server (NTRS)

Ku, Jentung; Ottenstein, Laura

2011-01-01

This paper describes thermal vacuum testing of a proto-flight miniature loop heat pipe (MLHP) with two evaporators and two condensers designed for future small systems applications requiring low mass, low power and compactness. Each evaporator contains a wick with an outer diameter of 6.35 mm, and each has its own integral compensation chamber (CC). Miniaturization of the loop components reduces the volume and mass of the thermal system. Multiple evaporators provide flexibility for placement of instruments that need to be maintained at the same temperature, and facilitate heat load sharing among instruments, reducing the auxiliary heater power requirement. A flow regulator is used to regulate heat dissipations between the two condensers, allowing flexible placement of radiators on the spacecraft. A thermoelectric converter (TEC) is attached to each CC for control of the operating temperature and enhancement of start-up success. Tests performed include start-up, power cycle, sink temperature cycle, high power and low power operation, heat load sharing, and operating temperature control. The proto-flight MLHP demonstrated excellent performance in the thermal vacuum test. The loop started successfully and operated stably under various evaporator heat loads and condenser sink temperatures. The TECs were able to maintain the loop operating temperature within b1K of the desired set point temperature at all power levels and all sink temperatures. The un-powered evaporator would automatically share heat from the other powered evaporator. The flow regulator was able to regulate the heat dissipation among the radiators and prevent vapor from flowing into the liquid line.

How Cognitive Load Influences Speakers' Choice of Referring Expressions.

PubMed

Vogels, Jorrig; Krahmer, Emiel; Maes, Alfons

2015-08-01

We report on two experiments investigating the effect of an increased cognitive load for speakers on the choice of referring expressions. Speakers produced story continuations to addressees, in which they referred to characters that were either salient or non-salient in the discourse. In Experiment 1, referents that were salient for the speaker were non-salient for the addressee, and vice versa. In Experiment 2, all discourse information was shared between speaker and addressee. Cognitive load was manipulated by the presence or absence of a secondary task for the speaker. The results show that speakers under load are more likely to produce pronouns, at least when referring to less salient referents. We take this finding as evidence that speakers under load have more difficulties taking discourse salience into account, resulting in the use of expressions that are more economical for themselves. © 2014 Cognitive Science Society, Inc.

Thermal elastohydrodynamic lubrication of spur gears

NASA Technical Reports Server (NTRS)

Wang, K. L.; Cheng, H. S.

1980-01-01

An analysis and computer program called TELSGE were developed to predict the variations of dynamic load, surface temperature, and lubricant film thickness along the contacting path during the engagement of a pair of involute spur gears. The analysis of dynamic load includes the effect of gear inertia, the effect of load sharing of adjacent teeth, and the effect of variable tooth stiffness which are obtained by a finite-element method. Results obtained from TELSGE for the dynamic load distributions along the contacting path for various speeds of a pair of test gears show patterns similar to that observed experimentally. Effects of damping ratio, contact ratio, tip relief, and tooth error on the dynamic load were examined. In addition, two dimensionless charts are included for predicting the maximum equilibrium surface temperature, which can be used to estimate directly the lubricant film thickness based on well established EHD analysis.

Normal Component of Induced Velocity for Entire Field of a Uniformly Loaded Lifting Rotor with Highly Swept Wake as Determined by Electromagnetic Analog

NASA Technical Reports Server (NTRS)

Castles, Walter, Jr.; Durham, Howard L., Jr.; Kevorkian, Jirair

1959-01-01

Values of the normal component of induced velocity throughout the entire field of a uniformly loaded r(rotor at high high speed are presented in the form of charts and tables. Many points were found by an electromagnetic analog, details of which are given. Comparisons of computed and analog values for the induced velocity indicate that the latter are sufficiently accurate for engineering purposes.

Airport Information Retrieval System (AIRS) User's Guide

DOT National Transportation Integrated Search

1973-08-01

The handbook is a user's guide for a prototype air traffic flow control automation system developed for the FAA's System Command Center. The system is implemented on a time-sharing computer and is designed to provide airport traffic load predictions ...

Airport Information Retrieval System (AIRS) System Support Manual

DOT National Transportation Integrated Search

1973-01-01

This handbook is a support manual for prototype air traffic flow control automation system developed for the FAA's Systems Command Center. The system is implemented on a time-sharing computer and is designed to provide airport traffic load prediction...

Load Balancing Strategies for Multiphase Flows on Structured Grids

NASA Astrophysics Data System (ADS)

Olshefski, Kristopher; Owkes, Mark

2017-11-01

The computation time required to perform large simulations of complex systems is currently one of the leading bottlenecks of computational research. Parallelization allows multiple processing cores to perform calculations simultaneously and reduces computational times. However, load imbalances between processors waste computing resources as processors wait for others to complete imbalanced tasks. In multiphase flows, these imbalances arise due to the additional computational effort required at the gas-liquid interface. However, many current load balancing schemes are only designed for unstructured grid applications. The purpose of this research is to develop a load balancing strategy while maintaining the simplicity of a structured grid. Several approaches are investigated including brute force oversubscription, node oversubscription through Message Passing Interface (MPI) commands, and shared memory load balancing using OpenMP. Each of these strategies are tested with a simple one-dimensional model prior to implementation into the three-dimensional NGA code. Current results show load balancing will reduce computational time by at least 30%.

Baby Carriage: Infants Walking with Loads

ERIC Educational Resources Information Center

Garciaguirre, Jessie S.; Adolph, Karen E.; Shrout, Patrick E.

2007-01-01

Maintaining balance is a central problem for new walkers. To examine how infants cope with the additional balance control problems induced by load carriage, 14-month-olds were loaded with 15% of their body weight in shoulder-packs. Both symmetrical and asymmetrical loads disrupted alternating gait patterns and caused less mature footfall patterns.…

The enteroinsular axis and endocrine pancreatic function in chronic alcohol consumers: evidence for early beta-cell hypofunction.

PubMed

Patto, R J; Russo, E K; Borges, D R; Neves, M M

1993-09-01

Chronic alcohol consumers may have, as judged by functional criteria, exocrine as well as endocrine pancreatic dysfunction, the latter represented by a decreased insulin response to an oral glucose load. To investigate whether this decreased insulin response was due to an ethanol-induced beta-cell dysfunction or to an ethanol-induced dysfunction of the enteroinsular axis, we determined glucose, insulin, and C-peptide plasma concentrations following an oral and an intravenous glucose load in 16 healthy volunteer nonalcohol consumers and in 10 chronic alcohol consumers. In each group, total integrated response for glucose did not significantly change whether glucose was given orally or intravenously, indicating isoglycemic glucose loads. The total integrated response values for insulin in the alcoholic group following both glucose loads as well as C-peptide plasma concentrations were significantly lower than in the control group. Moreover, in both groups the insulin TIR values following the oral glucose load were significantly greater than the values obtained following the intravenous glucose load, indicating an incretin effect. These results indicate that the decreased insulin response observed in alcoholics was not caused by a dysfunction of the enteroinsular axis because it also occurred following an intravenous glucose load, but by an ethanol-induced beta-cell dysfunction because C-peptide and insulin were proportionally decreased in this group.

Effect of Degeneration on Fluid-Solid Interaction within Intervertebral Disk Under Cyclic Loading - A Meta-Model Analysis of Finite Element Simulations.

PubMed

Nikkhoo, Mohammad; Khalaf, Kinda; Kuo, Ya-Wen; Hsu, Yu-Chun; Haghpanahi, Mohammad; Parnianpour, Mohamad; Wang, Jaw-Lin

2015-01-01

The risk of low back pain resulted from cyclic loadings is greater than that resulted from prolonged static postures. Disk degeneration results in degradation of disk solid structures and decrease of water contents, which is caused by activation of matrix digestive enzymes. The mechanical responses resulted from internal solid-fluid interactions of degenerative disks to cyclic loadings are not well studied yet. The fluid-solid interactions in disks can be evaluated by mathematical models, especially the poroelastic finite element (FE) models. We developed a robust disk poroelastic FE model to analyze the effect of degeneration on solid-fluid interactions within disk subjected to cyclic loadings at different loading frequencies. A backward analysis combined with in vitro experiments was used to find the elastic modulus and hydraulic permeability of intact and enzyme-induced degenerated porcine disks. The results showed that the averaged peak-to-peak disk deformations during the in vitro cyclic tests were well fitted with limited FE simulations and a quadratic response surface regression for both disk groups. The results showed that higher loading frequency increased the intradiscal pressure, decreased the total fluid loss, and slightly increased the maximum axial stress within solid matrix. Enzyme-induced degeneration decreased the intradiscal pressure and total fluid loss, and barely changed the maximum axial stress within solid matrix. The increase of intradiscal pressure and total fluid loss with loading frequency was less sensitive after the frequency elevated to 0.1 Hz for the enzyme-induced degenerated disk. Based on this study, it is found that enzyme-induced degeneration decreases energy attenuation capability of disk, but less change the strength of disk.

Curcumin-loaded nanoparticles ameliorate glial activation and improve myelin repair in lyolecithin-induced focal demyelination model of rat corpus callosum.

PubMed

Naeimi, Reza; Safarpour, Fatemeh; Hashemian, Mona; Tashakorian, Hamed; Ahmadian, Seyed Raheleh; Ashrafpour, Manouchehr; Ghasemi-Kasman, Maryam

2018-05-01

Curcumin has been introduced as effective anti-inflammatory agent in treatment of several inflammatory disorders. Despite the wide range pharmacological activities, clinical application of curcumin is restricted mainly due to the low water solubility of this substance. More recently, we could remarkably improve the aqueous solubility of curcumin by its encapsulation in chitosan-alginate-sodium tripolyphosphate nanoparticles (CS-ALG-STPP NPs). In this study, the anti-inflammatory and myelin protective effects of curcumin-loaded NPs were evaluated in lysolecithin (LPC)-induced focal demyelination model. Pharmacokinetic of curcumin was assessed using high performance liquid chromatography (HPLC). Local demyelination was induced by injection of LPC into corpus callosum of rats. Animals were pre-treated with intraperitoneal (i.p.) injections of curcumin or curcumin-loaded NPs at dose of 12.5 mg/kg, 10 days prior to LPC injection and the injections were continued for 7 or 14 days post lesion. Hematoxylin and eosin (H&E) staining and immunostaining against activated glial cells including astrocytes and microglia were carried out for assessment of inflammation level in lesion site. Myelin specific staining was performed to evaluate the effect of curcumin-loaded NPs on myelination of LPC receiving animals. HPLC results showed the higher plasma concentration of curcumin after administration of NPs. Histological evaluation demonstrated that, the extent of demyelination areas was reduced in animals under treatment of curcumin-loaded NPs. Furthermore, treatment with curcumin-loaded NPs effectively attenuated glial activation and inflammation in LPC-induced demyelination model compared to curcumin receiving animals. Overall; these findings indicate that treatment with curcumin-loaded NPs preserve myelinated axons through amelioration of glial activation and inflammation in demyelination context. Copyright © 2018 Elsevier B.V. All rights reserved.

Effect of Degeneration on Fluid–Solid Interaction within Intervertebral Disk Under Cyclic Loading – A Meta-Model Analysis of Finite Element Simulations

PubMed Central

Nikkhoo, Mohammad; Khalaf, Kinda; Kuo, Ya-Wen; Hsu, Yu-Chun; Haghpanahi, Mohammad; Parnianpour, Mohamad; Wang, Jaw-Lin

2015-01-01

The risk of low back pain resulted from cyclic loadings is greater than that resulted from prolonged static postures. Disk degeneration results in degradation of disk solid structures and decrease of water contents, which is caused by activation of matrix digestive enzymes. The mechanical responses resulted from internal solid–fluid interactions of degenerative disks to cyclic loadings are not well studied yet. The fluid–solid interactions in disks can be evaluated by mathematical models, especially the poroelastic finite element (FE) models. We developed a robust disk poroelastic FE model to analyze the effect of degeneration on solid–fluid interactions within disk subjected to cyclic loadings at different loading frequencies. A backward analysis combined with in vitro experiments was used to find the elastic modulus and hydraulic permeability of intact and enzyme-induced degenerated porcine disks. The results showed that the averaged peak-to-peak disk deformations during the in vitro cyclic tests were well fitted with limited FE simulations and a quadratic response surface regression for both disk groups. The results showed that higher loading frequency increased the intradiscal pressure, decreased the total fluid loss, and slightly increased the maximum axial stress within solid matrix. Enzyme-induced degeneration decreased the intradiscal pressure and total fluid loss, and barely changed the maximum axial stress within solid matrix. The increase of intradiscal pressure and total fluid loss with loading frequency was less sensitive after the frequency elevated to 0.1 Hz for the enzyme-induced degenerated disk. Based on this study, it is found that enzyme-induced degeneration decreases energy attenuation capability of disk, but less change the strength of disk. PMID:25674562

Shared and disorder-specific task-positive and default mode network dysfunctions during sustained attention in paediatric Attention-Deficit/Hyperactivity Disorder and obsessive/compulsive disorder.

PubMed

Norman, Luke J; Carlisi, Christina O; Christakou, Anastasia; Cubillo, Ana; Murphy, Clodagh M; Chantiluke, Kaylita; Simmons, Andrew; Giampietro, Vincent; Brammer, Michael; Mataix-Cols, David; Rubia, Katya

2017-01-01

Patients with Attention-Deficit/Hyperactivity Disorder (ADHD) and obsessive/compulsive disorder (OCD) share problems with sustained attention, and are proposed to share deficits in switching between default mode and task positive networks. The aim of this study was to investigate shared and disorder-specific brain activation abnormalities during sustained attention in the two disorders. Twenty boys with ADHD, 20 boys with OCD and 20 age-matched healthy controls aged between 12 and 18 years completed a functional magnetic resonance imaging (fMRI) version of a parametrically modulated sustained attention task with a progressively increasing sustained attention load. Performance and brain activation were compared between groups. Only ADHD patients were impaired in performance. Group by sustained attention load interaction effects showed that OCD patients had disorder-specific middle anterior cingulate underactivation relative to controls and ADHD patients, while ADHD patients showed disorder-specific underactivation in left dorsolateral prefrontal cortex/dorsal inferior frontal gyrus (IFG). ADHD and OCD patients shared left insula/ventral IFG underactivation and increased activation in posterior default mode network relative to controls, but had disorder-specific overactivation in anterior default mode regions, in dorsal anterior cingulate for ADHD and in anterior ventromedial prefrontal cortex for OCD. In sum, ADHD and OCD patients showed mostly disorder-specific patterns of brain abnormalities in both task positive salience/ventral attention networks with lateral frontal deficits in ADHD and middle ACC deficits in OCD, as well as in their deactivation patterns in medial frontal DMN regions. The findings suggest that attention performance in the two disorders is underpinned by disorder-specific activation patterns.

An Increase in Postural Load Facilitates an Anterior Shift of Processing Resources to Frontal Executive Function in a Postural-Suprapostural Task

PubMed Central

Huang, Cheng-Ya; Chang, Gwo-Ching; Tsai, Yi-Ying; Hwang, Ing-Shiou

2016-01-01

Increase in postural-demand resources does not necessarily degrade a concurrent motor task, according to the adaptive resource-sharing hypothesis of postural-suprapostural dual-tasking. This study investigated how brain networks are organized to optimize a suprapostural motor task when the postural load increases and shifts postural control into a less automatic process. Fourteen volunteers executed a designated force-matching task from a level surface (a relative automatic process in posture) and from a stabilometer board while maintaining balance at a target angle (a relatively controlled process in posture). Task performance of the postural and suprapostural tasks, synchronization likelihood (SL) of scalp EEG, and graph-theoretical metrics were assessed. Behavioral results showed that the accuracy and reaction time of force-matching from a stabilometer board were not affected, despite a significant increase in postural sway. However, force-matching in the stabilometer condition showed greater local and global efficiencies of the brain networks than force-matching in the level-surface condition. Force-matching from a stabilometer board was also associated with greater frontal cluster coefficients, greater mean SL of the frontal and sensorimotor areas, and smaller mean SL of the parietal-occipital cortex than force-matching from a level surface. The contrast of supra-threshold links in the upper alpha and beta bands between the two stance conditions validated load-induced facilitation of inter-regional connections between the frontal and sensorimotor areas, but that contrast also indicated connection suppression between the right frontal-temporal and the parietal-occipital areas for the stabilometer stance condition. In conclusion, an increase in stance difficulty alters the neurocognitive processes in executing a postural-suprapostural task. Suprapostural performance is not degraded by increase in postural load, due to (1) increased effectiveness of information transfer, (2) an anterior shift of processing resources toward frontal executive function, and (3) cortical dissociation of control hubs in the parietal-occipital cortex for neural economy. PMID:27594830

Determination of brace forces caused by construction loads and wind loads during bridge construction.

DOT National Transportation Integrated Search

2014-04-01

The first objective of this study was to develop procedures for determining bracing forces during bridge construction. : Numerical finite element models and analysis techniques were developed for evaluating brace forces induced by construction loads ...

Human climbing with efficiently scaled gecko-inspired dry adhesives

PubMed Central

Hawkes, Elliot W.; Eason, Eric V.; Christensen, David L.; Cutkosky, Mark R.

2015-01-01

Since the discovery of the mechanism of adhesion in geckos, many synthetic dry adhesives have been developed with desirable gecko-like properties such as reusability, directionality, self-cleaning ability, rough surface adhesion and high adhesive stress. However, fully exploiting these adhesives in practical applications at different length scales requires efficient scaling (i.e. with little loss in adhesion as area grows). Just as natural gecko adhesives have been used as a benchmark for synthetic materials, so can gecko adhesion systems provide a baseline for scaling efficiency. In the tokay gecko (Gekko gecko), a scaling power law has been reported relating the maximum shear stress σmax to the area A: σmax ∝ A−1/4. We present a mechanical concept which improves upon the gecko's non-uniform load-sharing and results in a nearly even load distribution over multiple patches of gecko-inspired adhesive. We created a synthetic adhesion system incorporating this concept which shows efficient scaling across four orders of magnitude of area, yielding an improved scaling power law: σmax ∝ A−1/50. Furthermore, we found that the synthetic adhesion system does not fail catastrophically when a simulated failure is induced on a portion of the adhesive. In a practical demonstration, the synthetic adhesion system enabled a 70 kg human to climb vertical glass with 140 cm2 of adhesive per hand. PMID:25411404

Temporary sharing prompts unrestrained disclosures that leave lasting negative impressions.

PubMed

Hofstetter, Reto; Rüppell, Roland; John, Leslie K

2017-11-07

With the advent of social media, the impressions people make on others are based increasingly on their digital disclosures. However, digital disclosures can come back to haunt, making it challenging for people to manage the impressions they make. In field and online experiments in which participants take, share, and evaluate self-photographs ("selfies"), we show that, paradoxically, these challenges can be exacerbated by temporary-sharing media-technologies that prevent content from being stored permanently. Relative to permanent sharing, temporary sharing affects both whether and what people reveal. Specifically, temporary sharing increases compliance with the request to take a selfie (study 1) and induces greater disclosure risks (i.e., people exhibit greater disinhibition in their selfies, studies 1 and 2). This increased disclosure is driven by reduced privacy concerns (study 2). However, observers' impressions of sharers are insensitive to permanence (i.e., whether the selfie was shared temporarily versus permanently) and are instead driven by the disinhibition exhibited in the selfie (studies 4-7). As a result, induced by the promise of temporary sharing, sharers of uninhibited selfies come across as having worse judgment than those who share relatively discreet selfies (studies 1, 2, and 4-7)-an attributional pattern that is unanticipated by sharers (study 3), that persists days after the selfie has disappeared (study 5), is robust to personal experience with temporary sharing (studies 6A and 6B), and holds even among friends (studies 7A and 7B). Temporary sharing may bring back forgetting, but not without introducing new (self-presentational) challenges. Copyright © 2017 the Author(s). Published by PNAS.

Temporary sharing prompts unrestrained disclosures that leave lasting negative impressions

PubMed Central

Rüppell, Roland; John, Leslie K.

2017-01-01

With the advent of social media, the impressions people make on others are based increasingly on their digital disclosures. However, digital disclosures can come back to haunt, making it challenging for people to manage the impressions they make. In field and online experiments in which participants take, share, and evaluate self-photographs (“selfies”), we show that, paradoxically, these challenges can be exacerbated by temporary-sharing media—technologies that prevent content from being stored permanently. Relative to permanent sharing, temporary sharing affects both whether and what people reveal. Specifically, temporary sharing increases compliance with the request to take a selfie (study 1) and induces greater disclosure risks (i.e., people exhibit greater disinhibition in their selfies, studies 1 and 2). This increased disclosure is driven by reduced privacy concerns (study 2). However, observers’ impressions of sharers are insensitive to permanence (i.e., whether the selfie was shared temporarily versus permanently) and are instead driven by the disinhibition exhibited in the selfie (studies 4–7). As a result, induced by the promise of temporary sharing, sharers of uninhibited selfies come across as having worse judgment than those who share relatively discreet selfies (studies 1, 2, and 4–7)—an attributional pattern that is unanticipated by sharers (study 3), that persists days after the selfie has disappeared (study 5), is robust to personal experience with temporary sharing (studies 6A and 6B), and holds even among friends (studies 7A and 7B). Temporary sharing may bring back forgetting, but not without introducing new (self-presentational) challenges. PMID:29078302

Open Architecture Data System for NASA Langley Combined Loads Test System

NASA Technical Reports Server (NTRS)

Lightfoot, Michael C.; Ambur, Damodar R.

1998-01-01

The Combined Loads Test System (COLTS) is a new structures test complex that is being developed at NASA Langley Research Center (LaRC) to test large curved panels and cylindrical shell structures. These structural components are representative of aircraft fuselage sections of subsonic and supersonic transport aircraft and cryogenic tank structures of reusable launch vehicles. Test structures are subjected to combined loading conditions that simulate realistic flight load conditions. The facility consists of two pressure-box test machines and one combined loads test machine. Each test machine possesses a unique set of requirements or research data acquisition and real-time data display. Given the complex nature of the mechanical and thermal loads to be applied to the various research test articles, each data system has been designed with connectivity attributes that support both data acquisition and data management functions. This paper addresses the research driven data acquisition requirements for each test machine and demonstrates how an open architecture data system design not only meets those needs but provides robust data sharing between data systems including the various control systems which apply spectra of mechanical and thermal loading profiles.

Fatigue crack closure: a review of the physical phenomena

PubMed Central

Pippan, R.

2017-01-01

Abstract Plasticity‐induced, roughness‐induced and oxide‐induced crack closures are reviewed. Special attention is devoted to the physical origin, the consequences for the experimental determination and the prediction of the effective crack driving force for fatigue crack propagation. Plasticity‐induced crack closure under plane stress and plane strain conditions require, in principle, a different explanation; however, both types are predictable. This is even the case in the transition region from the plane strain to the plane stress state and all types of loading conditions including constant and variable amplitude loading, the short crack case or the transition from small‐scale to large‐scale yielding. In contrast, the prediction of roughness‐induced and oxide‐induced closures is not as straightforward. PMID:28616624

Leishmania infantum FML pulsed-dendritic cells induce a protective immune response in murine visceral leishmaniasis.

PubMed

Foroughi-Parvar, Faeze; Hatam, Gholam-Reza; Sarkari, Bahador; Kamali-Sarvestani, Eskandar

2015-01-01

To investigate the efficacy of FML loaded dendritic cells (DCs) in protection against visceral leishmaniasis. Mice were immunized with FML- or soluble Leishmania antigen-loaded DCs as well as FML or soluble Leishmania antigen in saponin and challenged with parasite. The levels of cytokines before and after challenge were detected by ELISA. Parasite burden (total Leishman-Donovan unit) was determined after parasite challenge. FML-saponin induced the highest IFN-γ/IL-4 ratio among vaccinated groups, though this ratio was higher in FML-loaded DCs group subsequent to challenge with Leishmania infantum. Moreover, the greatest reduction in parasite number was detected in mice vaccinated with FML-loaded DCs compared with phosphate-buffered saline-treated mice (p = 0.002). FML-loaded DCs are one of the promising tools for protection against murine visceral leishmaniasis.

Mother-to-child transmission of HIV-1: strong association with certain maternal HLA-B alleles independent of viral load implicates innate immune mechanisms.

PubMed

Winchester, Robert; Pitt, Jane; Charurat, Manhattan; Magder, Laurence S; Göring, Harald H H; Landay, Alan; Read, Jennifer S; Shearer, William; Handelsman, Edward; Luzuriaga, Katherine; Hillyer, George V; Blattner, William

2004-06-01

The transmission of HIV-1 from mother to child during pregnancy is unlike other types of HIV-1 transmission because the child shares major histocompatibility complex (MHC) genes with the mother during a time while the mother is induced to tolerate the paternally derived fetal MHC molecules, in part through natural killer (NK) recognition of MHC polymorphisms. The relevance of these immune mechanisms to HIV-1 transmission was assessed by determining the HLA-B alleles of mother and infant. Almost half (48%) of mothers who transmitted with low viral loads had HLA-B*1302, B*3501, B*3503, B*4402, or B*5001 alleles, compared with 8% of nontransmitting mothers (P=0.001). Conversely, 25% of mothers who did not transmit despite high viral loads had B*4901 and B*5301, vs. 5% of transmitting mothers (P=0.003), a pattern of allelic involvement distinct from that influencing HIV-1 infection outcome. The infant's HLA-B alleles did not appear associated with transmission risk. The HLA-B*4901 and B*5301 alleles that were protective in the mother both differed respectively from the otherwise identical susceptibility alleles, B*5001 and B*3501, by 5 amino acids encoding the ligand for the KIR3DL1 NK receptor. These results suggest that the probable molecular basis of the observed association involves definition of the maternal NK recognition repertoire by engagement of NK receptors with polymorphic ligands encoded by maternal HLA-B alleles, and that the placenta is the likely site of the effect that appears to protect against transmission of maternal HIV-1 through interrelating adaptive and innate immune recognition.

Metallographic autopsies of full-scale ITER prototype cable-in-conduit conductors after full cyclic testing in SULTAN: III. The importance of strand surface roughness in long twist pitch conductors

DOE PAGES

Sanabria, Charlie; Lee, Peter J.; Starch, William; ...

2016-05-31

As part of the ITER conductor qualification process, 3 m long Cable-in-Conduit Conductors (CICCs) were tested at the SULTAN facility under conditions simulating ITER operation so as to establish the current sharing temperature, T cs, as a function of multiple full Lorentz force loading cycles. After a comprehensive evaluation of both the Toroidal Field (TF) and the Central Solenoid (CS) conductors, it was found that T cs degradation was common in long twist pitch TF conductors while short twist pitch CS conductors showed some T cs increase. However, one kind of TF conductors containing superconducting strand fabricated by the Bochvarmore » Institute of Inorganic Materials (VNIINM) avoided T cs degradation despite having long twist pitch. In our earlier metallographic autopsies of long and short twist pitch CS conductors, we observed a substantially greater transverse strand movement under Lorentz force loading for long twist pitch conductors, while short twist pitch conductors had negligible transverse movement. With help from the literature, we concluded that the transverse movement was not the source of T cs degradation but rather an increase of the compressive strain in the Nb 3Sn filaments possibly induced by longitudinal movement of the wires. Like all TF conductors this TF VNIINM conductor showed large transverse motions under Lorentz force loading, but Tcs actually increased, as in all short twist pitch CS conductors. We here propose that the high surface roughness of the VNIINM strand may be responsible for the suppression of the compressive strain enhancement (characteristic of long twist pitch conductors). Furthermore, it appears that increasing strand surface roughness could improve the performance of long twist pitch CICCs.« less

Metallographic autopsies of full-scale ITER prototype cable-in-conduit conductors after full cyclic testing in SULTAN: III. The importance of strand surface roughness in long twist pitch conductors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sanabria, Charlie; Lee, Peter J.; Starch, William

As part of the ITER conductor qualification process, 3 m long Cable-in-Conduit Conductors (CICCs) were tested at the SULTAN facility under conditions simulating ITER operation so as to establish the current sharing temperature, T cs, as a function of multiple full Lorentz force loading cycles. After a comprehensive evaluation of both the Toroidal Field (TF) and the Central Solenoid (CS) conductors, it was found that T cs degradation was common in long twist pitch TF conductors while short twist pitch CS conductors showed some T cs increase. However, one kind of TF conductors containing superconducting strand fabricated by the Bochvarmore » Institute of Inorganic Materials (VNIINM) avoided T cs degradation despite having long twist pitch. In our earlier metallographic autopsies of long and short twist pitch CS conductors, we observed a substantially greater transverse strand movement under Lorentz force loading for long twist pitch conductors, while short twist pitch conductors had negligible transverse movement. With help from the literature, we concluded that the transverse movement was not the source of T cs degradation but rather an increase of the compressive strain in the Nb 3Sn filaments possibly induced by longitudinal movement of the wires. Like all TF conductors this TF VNIINM conductor showed large transverse motions under Lorentz force loading, but Tcs actually increased, as in all short twist pitch CS conductors. We here propose that the high surface roughness of the VNIINM strand may be responsible for the suppression of the compressive strain enhancement (characteristic of long twist pitch conductors). Furthermore, it appears that increasing strand surface roughness could improve the performance of long twist pitch CICCs.« less

Covariations of eating behaviors with other health-related behaviors among adolescents.

PubMed

Neumark-Sztainer, D; Story, M; Toporoff, E; Himes, J H; Resnick, M D; Blum, R W

1997-06-01

The study objectives are: (1) to examine and compare patterns of covariation of a wide range of health behaviors among adolescent boys and girls; (2) to determine whether eating behaviors are part of a larger construct of health-related behaviors and to identify the behaviors with which they share underlying similarities; and (3) to determine whether youth engaging in other health-compromising behaviors are at risk for unhealthy eating. Data were analyzed from the Minnesota Adolescent Health Survey, a classroom-administered questionnaire, completed by 36,284 adolescents, in grades 7-12 from 1986-87. Among boys, factor analysis revealed five factors: (1) risk-taking behaviors, (2) school-related behaviors, (3) "quietly" disturbed behaviors (e.g., frequent dieting, self-induced vomiting, suicide attempts), (4) health-promoting behaviors; and (5) exercise. Eating behaviors loaded on the construct of health-promoting behaviors with brushing teeth and seat belt use. Among girls, four similar factors emerged; however, exercise loaded on the construct of health-promoting behaviors. Therefore, eating behaviors loaded with brushing teeth, seat belt use, and exercise among girls. Logistic regression analyses, controlling for sociodemographic and personal variables, revealed that boys and girls engaging in health-promoting behaviors were less likely to have unhealthy eating behaviors, while those engaging in quietly disturbed behaviors, risk-taking behaviors, and problematic school behaviors were more likely to have unhealthy eating behaviors. Eating behaviors appear to be part of a health-promoting behavioral construct and should not be viewed in isolation from other behaviors. Although eating behaviors do not appear to be part of the "problem behavior syndrome," youth engaging in a wide range of health-compromising behaviors are at risk for unhealthy eating; emphasizing the need to target high-risk youth with health promotion programs.

Hydrologically-driven crustal stresses and seismicity in the New Madrid Seismic Zone.

PubMed

Craig, Timothy J; Chanard, Kristel; Calais, Eric

2017-12-15

The degree to which short-term non-tectonic processes, either natural and anthropogenic, influence the occurrence of earthquakes in active tectonic settings or 'stable' plate interiors, remains a subject of debate. Recent work in plate-boundary regions demonstrates the capacity for long-wavelength changes in continental water storage to produce observable surface deformation, induce crustal stresses and modulate seismicity rates. Here we show that a significant variation in the rate of microearthquakes in the intraplate New Madrid Seismic Zone at annual and multi-annual timescales coincides with hydrological loading in the upper Mississippi embayment. We demonstrate that this loading, which results in geodetically observed surface deformation, induces stresses within the lithosphere that, although of small amplitude, modulate the ongoing seismicity of the New Madrid region. Correspondence between surface deformation, hydrological loading and seismicity rates at both annual and multi-annual timescales indicates that seismicity variations are the direct result of elastic stresses induced by the water load.

Photoenhanced gene transfection by a curcumin loaded CS-g-PZLL micelle.

PubMed

Lin, Jian-Tao; Pan, Wen-Jia; Zhang, Jun-Ai; Wang, Wei; Zhong, Jia; Su, Jia-Min; Li, Tong; Zou, Ying; Wang, Guan-Hai

2017-09-01

The codelivery of drug and gene is a promising method for cancer treatment. In our previous works, we prepared a cationic micelles based on chitosan and poly-(N-3-carbobenzyloxylysine) (CS-g-PZLL), but transfection ratio of CS-g-PZLL to Hela cell was low. Herein, to improve the transfection efficiency of CS-g-PZLL, curcumin was loaded in the CS-g-PZLL micelle. After irradiation, the obtained curcumin loaded micelle showed a better transfection, and the p53 protein expression in Hela cells was higher. The apoptosis assay showed that the complex could induce a more significant apoptosis to Hela cells than that of curcumin or p53 used alone, and the curcumin loaded micelle inducing apoptosis was best after irradiation. Therefore, CS-g-PZLL is a safe and effective carrier for the codelivery of drug/gene, and curcumin could be used as a photosensitizer to induce a photoenhanced gene transfection, which should be encouraged in improving transfection and tumor therapy. Copyright © 2017. Published by Elsevier B.V.

The Effects of Task-Induced Involvement Load on Word Learning and Confidence Judgments Mediated by Knowledge and Regulation of Cognition

ERIC Educational Resources Information Center

Teng, Feng

2017-01-01

The relationships between knowledge and regulation of cognition and how they interact to mediate the effects of task-induced involvement load on word learning and confidence judgments were investigated. The participants were 77 undergraduate English majors. They were required to complete a checklist on metacognition. Subsequently, they were…

The Relationship between Task-Induced Involvement Load and Learning New Words from Context

ERIC Educational Resources Information Center

Nassaji, Hossein; Hu, Hsueh-chao Marcella

2012-01-01

This study investigated the relationship between task-induced involvement load and ESL learners' inferencing and learning word meanings from context. Thirty-two ESL learners were randomly assigned to one of three groups, with each group receiving a different version of a text that was assumed to differ from one another in terms of the degree of…

The profile of psychiatric symptoms exacerbated by methamphetamine use.

PubMed

McKetin, Rebecca; Dawe, Sharon; Burns, Richard A; Hides, Leanne; Kavanagh, David J; Teesson, Maree; McD Young, Ross; Voce, Alexandra; Saunders, John B

2016-04-01

Methamphetamine use can produce symptoms almost indistinguishable from schizophrenia. Distinguishing between the two conditions has been hampered by the lack of a validated symptom profile for methamphetamine-induced psychiatric symptoms. We use data from a longitudinal cohort study to examine the profile of psychiatric symptoms that are acutely exacerbated by methamphetamine use. 164 methamphetamine users, who did not meet DSM-IV criteria for a lifetime primary psychotic disorder, were followed monthly for one year to assess the relationship between days of methamphetamine use and symptom severity on the 24-item Brief Psychiatric Rating Scale. Exacerbation of psychiatric symptoms with methamphetamine use was quantified using random coefficient models. The dimensions of symptom exacerbation were examined using principal axis factoring and a latent profile analysis. Symptoms exacerbated by methamphetamine loaded on three factors: positive psychotic symptoms (suspiciousness, unusual thought content, hallucinations, bizarre behavior); affective symptoms (depression, suicidality, guilt, hostility, somatic concern, self-neglect); and psychomotor symptoms (tension, excitement, distractibility, motor hyperactivity). Methamphetamine use did not significantly increase negative symptoms. Vulnerability to positive psychotic and affective symptom exacerbation was shared by 28% of participants, and this vulnerability aligned with a past year DSM-IV diagnosis of substance-induced psychosis (38% vs. 22%, χ(2)(df1)=3.66, p=0.056). Methamphetamine use produced a symptom profile comprised of positive psychotic and affective symptoms, which aligned with a diagnosis of substance-induced psychosis, with no evidence of a negative syndrome. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

A comparison between theoretical prediction and experimental measurement of the dynamic behavior of spur gears

NASA Technical Reports Server (NTRS)

Rebbechi, Brian; Forrester, B. David; Oswald, Fred B.; Townsend, Dennis P.

1992-01-01

A comparison was made between computer model predictions of gear dynamics behavior and experimental results. The experimental data were derived from the NASA gear noise rig, which was used to record dynamic tooth loads and vibration. The experimental results were compared with predictions from the DSTO Aeronautical Research Laboratory's gear dynamics code for a matrix of 28 load speed points. At high torque the peak dynamic load predictions agree with the experimental results with an average error of 5 percent in the speed range 800 to 6000 rpm. Tooth separation (or bounce), which was observed in the experimental data for light torque, high speed conditions, was simulated by the computer model. The model was also successful in simulating the degree of load sharing between gear teeth in the multiple tooth contact region.

A novel strategy for load balancing of distributed medical applications.

PubMed

Logeswaran, Rajasvaran; Chen, Li-Choo

2012-04-01

Current trends in medicine, specifically in the electronic handling of medical applications, ranging from digital imaging, paperless hospital administration and electronic medical records, telemedicine, to computer-aided diagnosis, creates a burden on the network. Distributed Service Architectures, such as Intelligent Network (IN), Telecommunication Information Networking Architecture (TINA) and Open Service Access (OSA), are able to meet this new challenge. Distribution enables computational tasks to be spread among multiple processors; hence, performance is an important issue. This paper proposes a novel approach in load balancing, the Random Sender Initiated Algorithm, for distribution of tasks among several nodes sharing the same computational object (CO) instances in Distributed Service Architectures. Simulations illustrate that the proposed algorithm produces better network performance than the benchmark load balancing algorithms-the Random Node Selection Algorithm and the Shortest Queue Algorithm, especially under medium and heavily loaded conditions.

The Effect of Shared Information on Pilot/Controller And Controller/Controller Interactions

NASA Technical Reports Server (NTRS)

Hansman, R. John

1999-01-01

In order to respond to the increasing demand on limited airspace system resources, a number of applications of information technology have been proposed, or are under investigation, to improve the efficiency, capacity and reliability of ATM (Asynchronous Transfer Mode) operations. Much of the attention in advanced ATM technology has focused on advanced automation systems or decision aiding systems to improve the performance of individual Pilots or Controllers. However, the most significant overall potential for information technology appears to he in increasing the shared information between human agents such as Pilots, Controllers or between interacting Controllers or traffic flow managers. Examples of proposed shared information systems in the US include; Controller Pilot Databank Communication (CPDLC), Traffic Management Advisor (TMA); Automatic Dependent Surveillance (ADS); Collaborative Decision Making (CDM) and NAS Level Common Information Exchange. Air Traffic Management is fundamentally a human centered process consisting of the negotiation, execution and monitoring of contracts between human agents for the allocation of limited airspace, runway and airport surface resources. The decision processes within ATM tend to be Semistructured. Many of the routine elements in ATM decision making on the part of the Controllers or Pilots are well Structured and can be represented by well defined rules or procedures. However in disrupted conditions, the ATM decision processes are often Unstructured and cannot be reduced to a set of discrete rules. As a consequence, the ability to automate ATM processes will be limited and ATM will continue to be a human centric process where the responsibility and the authority for the negotiation will continue to rest with human Controllers and Pilots. The use of information technology to support the human decision process will therefore be an important aspect of ATM modernization. The premise of many of the proposed shared information systems is that the performance of ATM operations will improve with an increase in Shared Situation Awareness between agents (Pilots, Controller, Dispatchers). This will allow better informed control decisions and an improved ability to negotiate between agents. A common information basis may reduce communication load and may increase the level of collaboration in the decision process. In general, information sharing is expected to have advantages for all agents within the system. However there are important questions which remain to be,addressed. For example: What shared information is most important for developing effective Shared Situation Awareness? Are there issues of information saturation? Does information parity create ambiguity in control authority? Will information sharing induce undesirable or unstable gaming behavior between agents? This paper will explore the effect of current and proposed information sharing between different ATM agents. The paper will primarily concentrate on bilateral tactical interactions between specific agents (Pilot/Controller; Controller/Controller; Pilot/Dispatcher; Controller/Dispatcher) however it will also briefly discuss multilateral interaction and more strategic interactions.

Unstructured P2P Network Load Balance Strategy Based on Multilevel Partitioning of Hypergraph

NASA Astrophysics Data System (ADS)

Feng, Lv; Chunlin, Gao; Kaiyang, Ma

2017-05-01

With rapid development of computer performance and distributed technology, P2P-based resource sharing mode plays important role in Internet. P2P network users continued to increase so the high dynamic characteristics of the system determine that it is difficult to obtain the load of other nodes. Therefore, a dynamic load balance strategy based on hypergraph is proposed in this article. The scheme develops from the idea of hypergraph theory in multilevel partitioning. It adopts optimized multilevel partitioning algorithms to partition P2P network into several small areas, and assigns each area a supernode for the management and load transferring of the nodes in this area. In the case of global scheduling is difficult to be achieved, the priority of a number of small range of load balancing can be ensured first. By the node load balance in each small area the whole network can achieve relative load balance. The experiments indicate that the load distribution of network nodes in our scheme is obviously compacter. It effectively solves the unbalanced problems in P2P network, which also improve the scalability and bandwidth utilization of system.

Bone Strength Estimated by Micro-Finite Element Analysis (µFEA) Is Heritable and Shares Genetic Predisposition With Areal BMD: The Framingham Study.

PubMed

Karasik, David; Demissie, Serkalem; Lu, Darlene; Broe, Kerry E; Boyd, Steven K; Liu, Ching-Ti; Hsu, Yi-Hsiang; Bouxsein, Mary L; Kiel, Douglas P

2017-11-01

Genetic factors contribute to the risk of bone fractures, partly because of effects on bone strength. High-resolution peripheral quantitative computed tomography (HR-pQCT) estimates bone strength using micro-finite element analysis (µFEA). The goal of this study was to investigate if the bone failure load estimated by HR-pQCT-based µFEA is heritable and to what extent it shares genetic regulation with areal bone mineral density (aBMD). Bone microarchitecture was measured by HR-pQCT at the ultradistal tibia and ultradistal radius in adults from the Framingham Heart Study (n = 1087, mean age 72 years; 57% women). Radial and tibial failure load in compression were estimated by µFEA. Femoral neck (FN) and ultradistal forearm (UD) aBMD were measured by dual-energy X-ray absorptiometry (DXA). Heritability (h 2 ) of failure load and aBMD and genetic correlations between them was estimated adjusting for covariates (age and sex). Failure load values at the non-weight-bearing ultradistal radius and at the weight-bearing ultradistal tibia were highly correlated (r = 0.906; p < 0.001). Estimates of h 2 adjusted for covariates were 0.522 for the radius and 0.497 for the tibia. Additional adjustment for height did not impact on the h 2 results, but adjustment for aBMD at the UD and FN somewhat decreased h 2 point estimates: 0.222 and 0.380 for radius and tibia, respectively. In bivariate analysis, there was a high phenotypic and genetic correlation between covariate-adjusted failure load at the radius and UD aBMD (ρ P  = 0.826, ρ G  = 0.954, respectively), whereas environmental correlations were lower (ρ E  = 0.696), all highly significant (p < 0.001). Similar correlations were observed between tibial failure load and femoral neck aBMD (ρ P  = 0.577, ρ G  = 0.703, both p < 0.001; ρ E  = 0.432, p < 0.05). These data from adult members of families from a population-based cohort suggest that bone strength of distal extremities estimated by micro-finite element analysis is heritable and shares some genetic composition with areal BMD, regardless of the skeletal site. © 2017 American Society for Bone and Mineral Research. © 2017 American Society for Bone and Mineral Research.

Effectiveness of barnyard best management practices in Wisconsin

USGS Publications Warehouse

Stuntebeck, Todd D.; Bannerman, Roger T.

1998-01-01

In 1978, the Wisconsin Legislature committed to protecting water quality by enacting the Nonpoint Source Water Pollution Abatement Program. Through this program, cost-share money is provided within priority watersheds to control sources of nonpoint pollution. Most of the cost-share dollars for rural watersheds have been used to implement barnyard Best Management Practices (BMPs) because barnyards are believed to be a major source of pollutants, most notably phosphorus. Reductions in phosphorus loads of as much as 95 percent have been predicted for the barnyard BMPs recommended for priority watersheds.

Sea loads on ships and offshore structures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Faltinsen, O.

1990-01-01

The book introduces the theory of the structural loading on ships and offshore structures caused by wind, waves and currents, and goes on to describe the applications of this theory in terms of real structures. The main topics described are linear-wave induced motions, loads on floating structures, numerical methods for ascertaining wave induced motions and loads, viscous wave loads and damping, stationkeeping and water impact and entry. The applications of the theoretical principles are introduced with extensive use of exercises and examples. Applications covered include conventional ships, barges, high speed marine vehicles, semisubmersibles, tension leg platforms, moored or dynamic positionedmore » ships, risers, buoys, fishing nets, jacket structures and gravity platforms. One aim of the book is to provide a physical understanding through simplified mathematical models. In this way one can develop analytical tools to evaluate results from test models, full scale trials or computer simulation, and learns which parameters represent the major contributions and influences on sea loads.« less

Silk sericin loaded alginate nanoparticles: Preparation and anti-inflammatory efficacy.

PubMed

Khampieng, Thitikan; Aramwit, Pornanong; Supaphol, Pitt

2015-09-01

In this study, silk sericin loaded alginate nanoparticles were prepared by the emulsification method followed by internal crosslinking. The effects of various silk sericin loading concentration on particle size, shape, thermal properties, and release characteristics were investigated. The initial silk sericin loadings of 20, 40, and 80% w/w to polymer were incorporated into these alginate nanoparticles. SEM images showed a spherical shape and small particles of about 71.30-89.50 nm. TGA analysis showed that thermal stability slightly increased with increasing silk sericin loadings. FTIR analysis suggested interactions between alginate and silk sericin in the nanoparticles. The release study was performed in acetate buffer at normal skin conditions (pH 5.5; 32 °C). The release profiles of silk sericin exhibited initial rapid release, consequently with sustained release. These silk sericin loaded alginate nanoparticles were further incorporated into topical hydrogel and their anti-inflammatory properties were studied using carrageenan-induced paw edema assay. The current study confirms the hypothesis that the application of silk sericin loaded alginate nanoparticle gel can inhibit inflammation induced by carrageenan. Copyright © 2015 Elsevier B.V. All rights reserved.

CERN data services for LHC computing

NASA Astrophysics Data System (ADS)

Espinal, X.; Bocchi, E.; Chan, B.; Fiorot, A.; Iven, J.; Lo Presti, G.; Lopez, J.; Gonzalez, H.; Lamanna, M.; Mascetti, L.; Moscicki, J.; Pace, A.; Peters, A.; Ponce, S.; Rousseau, H.; van der Ster, D.

2017-10-01

Dependability, resilience, adaptability and efficiency. Growing requirements require tailoring storage services and novel solutions. Unprecedented volumes of data coming from the broad number of experiments at CERN need to be quickly available in a highly scalable way for large-scale processing and data distribution while in parallel they are routed to tape for long-term archival. These activities are critical for the success of HEP experiments. Nowadays we operate at high incoming throughput (14GB/s during 2015 LHC Pb-Pb run and 11PB in July 2016) and with concurrent complex production work-loads. In parallel our systems provide the platform for the continuous user and experiment driven work-loads for large-scale data analysis, including end-user access and sharing. The storage services at CERN cover the needs of our community: EOS and CASTOR as a large-scale storage; CERNBox for end-user access and sharing; Ceph as data back-end for the CERN OpenStack infrastructure, NFS services and S3 functionality; AFS for legacy distributed-file-system services. In this paper we will summarise the experience in supporting LHC experiments and the transition of our infrastructure from static monolithic systems to flexible components providing a more coherent environment with pluggable protocols, tuneable QoS, sharing capabilities and fine grained ACLs management while continuing to guarantee dependable and robust services.

Force sharing in high-power parallel servo-actuators

NASA Technical Reports Server (NTRS)

Neal, T. P.

1974-01-01

The various existing force sharing schemes were examined by conducting a literature survey. A list of potentially applicable concepts was compiled from this survey, and a brief analysis was then made of each concept, which resulted in two competing schemes being selected for in-depth evaluation. A functional design of the equalization logic for the two schemes was undertaken and specific space shuttle application was chosen for experimental evaluation. The application was scaled down so that existing hardware could be utilized. Next, an analog computer study was conducted to evaluate the more important characteristics of the two competing force sharing schemes. On the basis of the computers study, a final configuration was selected. A load simulator was then designed to evaluate this configuration on actual hardware.

Bifactor Modeling of the Positive and Negative Syndrome Scale: Generalized Psychosis Spans Schizoaffective, Bipolar, and Schizophrenia Diagnoses.

PubMed

Anderson, Ariana E; Marder, Stephen; Reise, Steven P; Savitz, Adam; Salvadore, Giacomo; Fu, Dong Jing; Li, Qingqin; Turkoz, Ibrahim; Han, Carol; Bilder, Robert M

2018-02-06

Common genetic variation spans schizophrenia, schizoaffective and bipolar disorders, but historically, these syndromes have been distinguished categorically. A symptom dimension shared across these syndromes, if such a general factor exists, might provide a clearer target for understanding and treating mental illnesses that share core biological bases. We tested the hypothesis that a bifactor model of the Positive and Negative Syndrome Scale (PANSS), containing 1 general factor and 5 specific factors (positive, negative, disorganized, excited, anxiety), explains the cross-diagnostic structure of symptoms better than the traditional 5-factor model, and examined the extent to which a general factor reflects the overall severity of symptoms spanning diagnoses in 5094 total patients with a diagnosis of schizophrenia, schizoaffective, and bipolar disorder. The bifactor model provided superior fit across diagnoses, and was closer to the "true" model, compared to the traditional 5-factor model (Vuong test; P < .001). The general factor included high loadings on 28 of the 30 PANSS items, omitting symptoms associated with the excitement and anxiety/depression domains. The general factor had highest total loadings on symptoms that are often associated with the positive and disorganization syndromes, but there were also substantial loadings on the negative syndrome thus leading to the interpretation of this factor as reflecting generalized psychosis. A bifactor model derived from the PANSS can provide a stronger framework for measuring cross-diagnostic psychopathology than a 5-factor model, and includes a generalized psychosis dimension shared at least across schizophrenia, schizoaffective, and bipolar disorder. © The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com

Composite Grids for Reinforcement of Concrete Structures.

DTIC Science & Technology

1998-06-01

to greater compressive loads before induced shear failure occurs. Concrete columns were tested in compression to explore alter- native... columns were tested on the same day as the fiber-reinforced concrete columns . Load /deflection readings were taken with the load cell to determine the...ln) Figure 78. Ultimate load vs toughness for the different beam types tested . USACERLTR-98/81 141 £\\

Heavy metal transport in large river systems: heavy metal emissions and loads in the Rhine and Elbe river basins

NASA Astrophysics Data System (ADS)

Vink, Rona; Behrendt, Horst

2002-11-01

Pollutant transport and management in the Rhine and Elbe basins is still of international concern, since certain target levels set by the international committees for protection of both rivers have not been reached. The analysis of the chain of emissions of point and diffuse sources to river loads will provide policy makers with a tool for effective management of river basins. The analysis of large river basins such as the Elbe and Rhine requires information on the spatial and temporal characteristics of both emissions and physical information of the entire river basin. In this paper, an analysis has been made of heavy metal emissions from various point and diffuse sources in the Rhine and Elbe drainage areas. Different point and diffuse pathways are considered in the model, such as inputs from industry, wastewater treatment plants, urban areas, erosion, groundwater, atmospheric deposition, tile drainage, and runoff. In most cases the measured heavy metal loads at monitoring stations are lower than the sum of the heavy metal emissions. This behaviour in large river systems can largely be explained by retention processes (e.g. sedimentation) and is dependent on the specific runoff of a catchment. Independent of the method used to estimate emissions, the source apportionment analysis of observed loads was used to determine the share of point and diffuse sources in the heavy metal load at a monitoring station by establishing a discharge dependency. The results from both the emission analysis and the source apportionment analysis of observed loads were compared and gave similar results. Between 51% (for Hg) and 74% (for Pb) of the total transport in the Elbe basin is supplied by inputs from diffuse sources. In the Rhine basin diffuse source inputs dominate the total transport and deliver more than 70% of the total transport. The diffuse hydrological pathways with the highest share are erosion and urban areas.

Distinct and shared cognitive functions mediate event- and time-based prospective memory impairment in normal ageing

PubMed Central

Gonneaud, Julie; Kalpouzos, Grégoria; Bon, Laetitia; Viader, Fausto; Eustache, Francis; Desgranges, Béatrice

2011-01-01

Prospective memory (PM) is the ability to remember to perform an action at a specific point in the future. Regarded as multidimensional, PM involves several cognitive functions that are known to be impaired in normal aging. In the present study, we set out to investigate the cognitive correlates of PM impairment in normal aging. Manipulating cognitive load, we assessed event- and time-based PM, as well as several cognitive functions, including executive functions, working memory and retrospective episodic memory, in healthy subjects covering the entire adulthood. We found that normal aging was characterized by PM decline in all conditions and that event-based PM was more sensitive to the effects of aging than time-based PM. Whatever the conditions, PM was linked to inhibition and processing speed. However, while event-based PM was mainly mediated by binding and retrospective memory processes, time-based PM was mainly related to inhibition. The only distinction between high- and low-load PM cognitive correlates lays in an additional, but marginal, correlation between updating and the high-load PM condition. The association of distinct cognitive functions, as well as shared mechanisms with event- and time-based PM confirms that each type of PM relies on a different set of processes. PMID:21678154

A Powerful Approach to Estimating Annotation-Stratified Genetic Covariance via GWAS Summary Statistics.

PubMed

Lu, Qiongshi; Li, Boyang; Ou, Derek; Erlendsdottir, Margret; Powles, Ryan L; Jiang, Tony; Hu, Yiming; Chang, David; Jin, Chentian; Dai, Wei; He, Qidu; Liu, Zefeng; Mukherjee, Shubhabrata; Crane, Paul K; Zhao, Hongyu

2017-12-07

Despite the success of large-scale genome-wide association studies (GWASs) on complex traits, our understanding of their genetic architecture is far from complete. Jointly modeling multiple traits' genetic profiles has provided insights into the shared genetic basis of many complex traits. However, large-scale inference sets a high bar for both statistical power and biological interpretability. Here we introduce a principled framework to estimate annotation-stratified genetic covariance between traits using GWAS summary statistics. Through theoretical and numerical analyses, we demonstrate that our method provides accurate covariance estimates, thereby enabling researchers to dissect both the shared and distinct genetic architecture across traits to better understand their etiologies. Among 50 complex traits with publicly accessible GWAS summary statistics (N total ≈ 4.5 million), we identified more than 170 pairs with statistically significant genetic covariance. In particular, we found strong genetic covariance between late-onset Alzheimer disease (LOAD) and amyotrophic lateral sclerosis (ALS), two major neurodegenerative diseases, in single-nucleotide polymorphisms (SNPs) with high minor allele frequencies and in SNPs located in the predicted functional genome. Joint analysis of LOAD, ALS, and other traits highlights LOAD's correlation with cognitive traits and hints at an autoimmune component for ALS. Copyright © 2017 American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

Ultraviolet B irradiation of the mouse eye induces pigmentation of the skin more strongly than does stress loading, by increasing the levels of prohormone convertase 2 and α-melanocyte-stimulating hormone.

PubMed

Hiramoto, K; Yamate, Y; Kobayashi, H; Ishii, M; Sato, E F; Inoue, M

2013-01-01

In previous studies, we made the unexpected finding that in mice, ultraviolet (UV)B irradiation of the eye increased the concentration of α-melanocyte-stimulating hormone (α-MSH) in plasma, and systemically stimulated epidermal melanocytes. To compare the extent of the pigmentation induced by social and restraint stress (which activate the hippocampus-pituitary system) with that induced by UVB irradiation. DBA/2 and sham-operated or hypophysectomized DBA/2 mice were subjected to local UVB exposure using a sunlamp directed at the eye, and two types of stress (social and restraint) were imposed. UVB irradiation of the eye or exposure to stress loading both increased the number of Dopa-positive melanocytes in the epidermis, and hypophysectomy strongly inhibited the UVB-induced and stress-induced stimulation of melanocytes. Irradiation of the eye caused a much greater increase in dopamine than did the stress load. Both UVB eye irradiation and stress increased the blood levels of α-MSH and adrenocorticotropic hormone (ACTH). In addition, the increase in plasma α-MSH was greater in animals subjected to UVB eye irradiation than in those subjected to stress loading, whereas the reverse occurred for plasma ACTH. UVB irradiation to the eye and stress loading increased the expression of prohormone convertase (PC)1/3 and PC2 in the pituitary gland. The increase in expression of pituitary PC2 was greater in animals subjected to UVB eye irradiation than to stress, whereas no difference was seen between the two groups for the increase in PC1/3. UVB eye irradiation exerts a stronger effect on pigmentation than stress loading, and is related to increased levels of α-MSH and PC2. © The Author(s). CED © 2012 British Association of Dermatologists.

Higher Estimated Net Endogenous Acid Production May Be Associated with Increased Prevalence of Nonalcoholic Fatty Liver Disease in Chinese Adults in Hong Kong

PubMed Central

Chan, Ruth; Wong, Vincent Wai-Sun; Chu, Winnie Chiu-Wing; Wong, Grace Lai-Hung; Li, Liz Sin; Leung, Jason; Chim, Angel Mei-Ling; Yeung, David Ka-Wai; Sea, Mandy Man-Mei; Woo, Jean; Chan, Francis Ka-Leung; Chan, Henry Lik-Yuen

2015-01-01

Nonalcoholic fatty liver disease (NAFLD) has been associated with reduced growth hormone levels and signaling. Such hormonal changes also occur in metabolic acidosis. Since mild metabolic acidosis can be diet induced, diet-induced acid load may constitute a nutritional factor with possible influence on NAFLD development. This study explored whether a higher diet-induced acid load is associated with an increased likelihood of NAFLD. Apparently healthy Chinese adults (330 male, 463 female) aged 19-72 years were recruited through population screening between 2008 and 2010 in a cross-sectional population-based study in Hong Kong. Estimated net endogenous acid production (NEAP) was calculated using Frassetto’s method and potential renal acid load (PRAL) was calculated using Remer’s method based on dietary data from a food frequency questionnaire. NAFLD was defined as intrahepatic triglyceride content at >5% by proton-magnetic resonance spectroscopy. Possible advanced fibrosis was defined as liver stiffness at >7.9 kPa by transient elastography. Multivariate logistic regression models were used to examine the association between each measure of dietary acid load and prevalent NAFLD or possible advanced fibrosis with adjustment for potential anthropometric and lifestyle factors. 220 subjects (27.7%) were diagnosed with NAFLD. Estimated NEAP was positively associated with the likelihood of having NAFLD after adjustment for age, sex, body mass index, current drinker status and the presence of metabolic syndrome [OR (95% CI) = 1.25 (1.02-1.52), p = 0.022]. The association was slightly attenuated but remained significant when the model was further adjusted for other dietary variables. No association between PRAL and NAFLD prevalence was observed. Both estimated NEAP and PRAL were not associated with the presence of possible advance fibrosis. Our findings suggest that there may be a modest association between diet-induced acid load and NAFLD. More studies are needed to ascertain the link between diet-induced acid load and NAFLD and to investigate the underlying mechanisms. PMID:25905490

The Feasibility of Analytic Models for Academic Planning: A Preliminary Analysis of Seven Quarters of Observations on the "Induced Course Load Matrix."

ERIC Educational Resources Information Center

Jewett, Frank I.; And Others

This paper reports on a project undertaken at Humboldt State College, California, to estimate the coefficients of the so-called "induced course load matrix," perhaps the single most vital component of some models that are being developed to aid administrative planning and decisionmaking in institutions of higher education. Chapter I, the…

Reciprocal Tutoring: Design with Cognitive Load Sharing

ERIC Educational Resources Information Center

Chou, Chih-Yueh; Chan, Tak-Wai

2016-01-01

"Reciprocal tutoring," as reported in "Exploring the design of computer supports for reciprocal tutoring" (Chan and Chou 1997), has extended the meaning and scope of "intelligent tutoring" originally implemented in stand alone computers. This research is a follow-up to our studies on a "learning companion…

40 CFR 1066.210 - Dynamometers.

Code of Federal Regulations, 2014 CFR

2014-07-01

... to recreate the mechanical inertia and frictional forces that a vehicle exerts on road surfaces... drive axles may share a single drive roll. Use good engineering judgment to ensure that the dynamometer... engineering judgment. (3) The load applied by the dynamometer simulates forces acting on the vehicle during...

NORTHEAST LOON STUDY WORKING GROUP PARTNERSHIP TO ASSESS ENVIRONMENTAL RISK

EPA Science Inventory

The Northeast Loon Study Working Group (NELSWG) was formed in 1994 to proactively identify threats to one of the Northeast's most popular waterbirds, the common loon, Gavia immer. Seventeen institutions have come together to identify strategy, coordinate the work load, and share ...

"Job-Sharing" Storage of Hydrogen in Ru/Li₂O Nanocomposites.

PubMed

Fu, Lijun; Tang, Kun; Oh, Hyunchul; Manickam, Kandavel; Bräuniger, Thomas; Chandran, C Vinod; Menzel, Alexander; Hirscher, Michael; Samuelis, Dominik; Maier, Joachim

2015-06-10

A "job-sharing" hydrogen storage mechanism is proposed and experimentally investigated in Ru/Li2O nanocomposites in which H(+) is accommodated on the Li2O side, while H(-) or e(-) is stored on the side of Ru. Thermal desorption-mass spectroscopy results show that after loading with D2, Ru/Li2O exhibits an extra desorption peak, which is in contrast to Ru nanoparticles or ball-milled Li2O alone, indicating a synergistic hydrogen storage effect due to the presence of both phases. By varying the ratio of the two phases, it is shown that the effect increases monotonically with the area of the heterojunctions, indicating interface related hydrogen storage. X-ray diffraction, Fourier transform infrared spectroscopy, and nuclear magnetic resonance results show that a weak LiO···D bond is formed after loading in Ru/Li2O nanocomposites with D2. The storage-pressure curve seems to favor H(+)/H(-) over H(+)/e(-) mechanism.

Data traffic reduction schemes for sparse Cholesky factorizations

NASA Technical Reports Server (NTRS)

Naik, Vijay K.; Patrick, Merrell L.

1988-01-01

Load distribution schemes are presented which minimize the total data traffic in the Cholesky factorization of dense and sparse, symmetric, positive definite matrices on multiprocessor systems with local and shared memory. The total data traffic in factoring an n x n sparse, symmetric, positive definite matrix representing an n-vertex regular 2-D grid graph using n (sup alpha), alpha is equal to or less than 1, processors are shown to be O(n(sup 1 + alpha/2)). It is O(n(sup 3/2)), when n (sup alpha), alpha is equal to or greater than 1, processors are used. Under the conditions of uniform load distribution, these results are shown to be asymptotically optimal. The schemes allow efficient use of up to O(n) processors before the total data traffic reaches the maximum value of O(n(sup 3/2)). The partitioning employed within the scheme, allows a better utilization of the data accessed from shared memory than those of previously published methods.

CE dual-homing protection in layer 1 VPN

NASA Astrophysics Data System (ADS)

Du, Shu; Peng, Yunfeng; Long, Keping

2008-11-01

Layer 1 VPN (L1VPN) extends the notion of VPN to the optical domain to provide virtually dedicated circuit like leased lines, so that the security is more enhanced. Despite their secure gains from channel isolation, VPNs still suffer fragilities resulting from link-failures or node-failures. Extensive activities on survivability designs for wavelength-routed optical networks are proposed, including various protection and restoration schemes, but concerns on network edge are rare. Dual-homing is an effective skill to achieve survivability gains for L1VPNs. There are two dual-homing mode: Active/Standby mode and Load-Sharing mode In this paper, we investigate the problem of PE assignment, which is the key of dual-homing design and is NP-hard. We formulate it as an integer programming problem, and propose heuristic solutions. Simulation results show that the proposed solutions work in a correct and effective way and the Load-Sharing mode has higher bandwidth efficiency than Active/Standby mode.

Visual short-term memory load strengthens selective attention.

PubMed

Roper, Zachary J J; Vecera, Shaun P

2014-04-01

Perceptual load theory accounts for many attentional phenomena; however, its mechanism remains elusive because it invokes underspecified attentional resources. Recent dual-task evidence has revealed that a concurrent visual short-term memory (VSTM) load slows visual search and reduces contrast sensitivity, but it is unknown whether a VSTM load also constricts attention in a canonical perceptual load task. If attentional selection draws upon VSTM resources, then distraction effects-which measure attentional "spill-over"-will be reduced as competition for resources increases. Observers performed a low perceptual load flanker task during the delay period of a VSTM change detection task. We observed a reduction of the flanker effect in the perceptual load task as a function of increasing concurrent VSTM load. These findings were not due to perceptual-level interactions between the physical displays of the two tasks. Our findings suggest that perceptual representations of distractor stimuli compete with the maintenance of visual representations held in memory. We conclude that access to VSTM determines the degree of attentional selectivity; when VSTM is not completely taxed, it is more likely for task-irrelevant items to be consolidated and, consequently, affect responses. The "resources" hypothesized by load theory are at least partly mnemonic in nature, due to the strong correspondence they share with VSTM capacity.

Recommendations on Model Fidelity for Wind Turbine Gearbox Simulations; NREL (National Renewable Energy Laboratory)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keller, J.; Lacava, W.; Austin, J.

2015-02-01

This work investigates the minimum level of fidelity required to accurately simulate wind turbine gearboxes using state-of-the-art design tools. Excessive model fidelity including drivetrain complexity, gearbox complexity, excitation sources, and imperfections, significantly increases computational time, but may not provide a commensurate increase in the value of the results. Essential designparameters are evaluated, including the planetary load-sharing factor, gear tooth load distribution, and sun orbit motion. Based on the sensitivity study results, recommendations for the minimum model fidelities are provided.

Pupillary transient responses to within-task cognitive load variation.

PubMed

Wong, Hoe Kin; Epps, Julien

2016-12-01

Changes in physiological signals due to task evoked cognitive load have been reported extensively. However, pupil size based approaches for estimating cognitive load on a moment-to-moment basis are not as well understood as estimating cognitive load on a task-to-task basis, despite the appeal these approaches have for continuous load estimation. In particular, the pupillary transient response to instantaneous changes in induced load has not been experimentally quantified, and the within-task changes in pupil dilation have not been investigated in a manner that allows their consistency to be quantified with a view to biomedical system design. In this paper, a variation of the digit span task is developed which reliably induces rapid changes of cognitive load to generate task-evoked pupillary responses (TEPRs) associated with large, within-task load changes. Linear modelling and one-way ANOVA reveals that increasing the rate of cognitive loading, while keeping task demands constant, results in a steeper pupillary response. Instantaneous drops in cognitive load are shown to produce statistically significantly different transient pupillary responses relative to sustained load, and when characterised using an exponential decay response, the task-evoked pupillary response time constant is in the order of 1-5 s. Within-task test-retest analysis confirms the reliability of the moment-to-moment measurements. Based on these results, estimates of pupil diameter can be employed with considerably more confidence in moment-to-moment cognitive load estimation systems. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Enhancement and suppression in the visual field under perceptual load.

PubMed

Parks, Nathan A; Beck, Diane M; Kramer, Arthur F

2013-01-01

The perceptual load theory of attention proposes that the degree to which visual distractors are processed is a function of the attentional demands of a task-greater demands increase filtering of irrelevant distractors. The spatial configuration of such filtering is unknown. Here, we used steady-state visual evoked potentials (SSVEPs) in conjunction with time-domain event-related potentials (ERPs) to investigate the distribution of load-induced distractor suppression and task-relevant enhancement in the visual field. Electroencephalogram (EEG) was recorded while subjects performed a foveal go/no-go task that varied in perceptual load. Load-dependent distractor suppression was assessed by presenting a contrast reversing ring at one of three eccentricities (2, 6, or 11°) during performance of the go/no-go task. Rings contrast reversed at 8.3 Hz, allowing load-dependent changes in distractor processing to be tracked in the frequency-domain. ERPs were calculated to the onset of stimuli in the load task to examine load-dependent modulation of task-relevant processing. Results showed that the amplitude of the distractor SSVEP (8.3 Hz) was attenuated under high perceptual load (relative to low load) at the most proximal (2°) eccentricity but not at more eccentric locations (6 or 11°). Task-relevant ERPs revealed a significant increase in N1 amplitude under high load. These results are consistent with a center-surround configuration of load-induced enhancement and suppression in the visual field.

Moving objects with clumsy fingers: how predictive is grip force control in patients with impaired manual sensibility?

PubMed

Nowak, Dennis A; Hermsdörfer, Joachim; Marquardt, Christian; Topka, Helge

2003-03-01

Anticipatory grip force adjustments to movement-induced load fluctuations of a hand-held object suggest that motion planning is based on an internal forward model of both the external object properties and the dynamics of the own motor apparatus. However, the central nervous system also refers to real time sensory feedback from the grasping digits in order to achieve a highly economical coupling between grip force and the actual loading requirements. We analyzed grip force control during vertical point-to-point arm movements with a hand-held instrumented object in 9 patients with moderately impaired tactile sensibility of the grasping digits due to chronic median nerve compression (n = 3), axonal (n = 3) and demyelinating sensory polyneuropathy (n = 3) in comparison to 9 healthy age- and sex-matched control subjects. Point-to-point arm movements started and ended with the object being held stationary at rest. Load force changes arose from inertial loads related to the movement. A maximum of load force occurred early in upward and near the end of downward movements. Compared to healthy controls, patients with impaired manual sensibility generated similar static grip forces during stationary holding of the object and similar force ratios between maximum grip and load force. These findings reflect effective grip force scaling in relation to the movement-induced loads despite reduced afferent feedback from the grasping digits. For both groups the maxima of grip and load force coincided very closely in time, indicating that the temporal regulation of the grip force profile with the load profile was processed with a similar high precision. In addition, linear regression analyses between grip and load forces during movement-related load increase and load decrease phases revealed a similar precise temporo-spatial coupling between grip and load forces for patients and controls. Our results suggest that the precise and anticipatory adjustment of the grip force profile to the load force profile arising from voluntary arm movements with a hand-held object is centrally mediated and less under sensory feedback control. As suggested by previous investigations, the efficient scaling of the grip force magnitude in relation to the movement-induced loads may be intact when deficits of tactile sensibility from the grasping fingers are moderate.

Improving the Response of a Load Cell by Using Optimal Filtering

PubMed Central

Hernandez, Wilmar

2006-01-01

Load cells are transducers used to measure force or weight. Despite the fact that there is a wide variety of load cells, most of these transducers that are used in the weighing industry are based on strain gauges. In this paper, an s-beam load cell based on strain gauges was suitably assembled to the mechanical structure of several seats of a bus under performance tests and used to measure the resistance of their mechanical structure to tension forces applied horizontally to the seats being tested. The load cell was buried in a broad-band noise background where the unwanted information and the relevant signal sometimes share a very similar frequency spectrum and its performance was improved by using a recursive least-squares (RLS) lattice algorithm. The experimental results are satisfactory and a significant improvement in the signal-to-noise ratio at the system output of 27 dB was achieved, which is a good performance factor for judging the quality of the system.

Global Anthropogenic Phosphorus Loads to Fresh Water, Grey Water Footprint and Water Pollution Levels: A High-Resolution Global Study

NASA Astrophysics Data System (ADS)

Mekonnen, M. M.; Hoekstra, A. Y. Y.

2014-12-01

We estimated anthropogenic phosphorus (P) loads to freshwater, globally at a spatial resolution level of 5 by 5 arc minute. The global anthropogenic P load to freshwater systems from both diffuse and point sources in the period 2002-2010 was 1.5 million tonnes per year. China contributed about 30% to this global anthropogenic P load. India was the second largest contributor (8%), followed by the USA (7%), Spain and Brazil each contributing 6% to the total. The domestic sector contributed the largest share (54%) to this total followed by agriculture (38%) and industry (8%). Among the crops, production of cereals had the largest contribution to the P loads (32%), followed by fruits, vegetables, and oil crops, each contributing about 15% to the total. We also calculated the resultant grey water footprints, and relate the grey water footprints per river basin to runoff to calculate the P-related water pollution level (WPL) per catchment.

Testing of a Miniature Loop Heat Pipe with Multiple Evaporators and Multiple Condensers for Space Applications

NASA Technical Reports Server (NTRS)

Nagano, Hosei; Ku, Jentung

2006-01-01

Thermal performance of a miniature loop heat pipe (MLHP) with two evaporators and two condensers is described. A comprehensive test program, including start-up, high power, low power, power cycle, and sink temperature cycle tests, has been executed at NASA Goddard Space Flight Center for potential space applications. Experimental data showed that the loop could start with heat loads as low as 2W. The loop operated stably with even and uneven evaporator heat loads, and even and uneven condenser sink temperatures. Heat load sharing between the two evaporators was also successfully demonstrated. The loop had a heat transport capability of l00W to 120W, and could recover from a dry-out by reducing the heat load to evaporators. Low power test results showed the loop could work stably for heat loads as low as 1 W to each evaporator. Excellent adaptability of the MLHP to rapid changes of evaporator power and sink temperature were also demonstrated.

Load environment of rail joint bars - phase I, effects of track parameters on rail joint stresses and crack growth.

DOT National Transportation Integrated Search

2013-04-01

The load environment of joint bars was assessed under a variety of loading and track conditions. Bending stresses, thermal stresses, and residual stresses were measured on commonly used joint bars. Crack growth rates from artificially induced cracks ...

Load Induced Blindness

ERIC Educational Resources Information Center

Macdonald, James S. P.; Lavie, Nilli

2008-01-01

Although the perceptual load theory of attention has stimulated a great deal of research, evidence for the role of perceptual load in determining perception has typically relied on indirect measures that infer perception from distractor effects on reaction times or neural activity (see N. Lavie, 2005, for a review). Here we varied the level of…

Influence of Temperature on Fatigue-Induced Martensitic Phase Transformation in a Metastable CrMnNi-Steel

NASA Astrophysics Data System (ADS)

Biermann, Horst; Glage, Alexander; Droste, Matthias

2016-01-01

Metastable austenitic steels can exhibit a fatigue-induced martensitic phase transformation during cyclic loading. It is generally agreed that a certain strain amplitude and a threshold of the cumulated plastic strain must be exceeded to trigger martensitic phase transformation under cyclic loading. With respect to monotonic loading, the martensitic phase transformation takes place up to a critical temperature—the so-called M d temperature. The goal of the present investigation is to determine an M d,c temperature which would be the highest temperature at which a fatigue-induced martensitic phase transformation can take place. For this purpose, fatigue tests controlled by the total strain were performed at different temperatures. The material investigated was a high-alloy metastable austenitic steel X3CrMnNi16.7.7 (16.3Cr-7.2Mn-6.6Ni-0.03C-0.09N-1.0Si) produced using the hot pressing technique. The temperatures were set in the range of 283 K (10 °C) ≤ T ≤ 473 K (200 °C). Depending on the temperature and strain amplitude, the onset of the martensitic phase transformation shifted to different values of the cumulated plastic strain, or was inhibited completely. Moreover, it is known that metastable austenitic CrMnNi steels with higher nickel contents can exhibit the deformation-induced twinning effect. Thus, at higher temperatures and strain amplitudes, a transition from the deformation-induced martensitic transformation to deformation-induced twinning takes place. The fatigue-induced martensitic phase transformation was monitored during cyclic loading using a ferrite sensor. The microstructure after the fatigue tests was examined using the back-scattered electrons, the electron channeling contrast imaging and the electron backscatter diffraction techniques to study the temperature-dependent dislocation structures and phase transformations.

Biomechanical comparison of effects of the Dynesys and Coflex dynamic stabilization systems on range of motion and loading characteristics in the lumbar spine: a finite element study.

PubMed

Kulduk, Ahmet; Altun, Necdet S; Senkoylu, Alpaslan

2015-12-01

The primary purpose of dynamic stabilization is to preserve the normal range of motion (ROM) by restricting abnormal movement in the spine. Our aim was to analyze the effects of two different dynamic stabilization systems using finite element modeling (FEM). Coflex and Dynesys dynamic devices were modeled and implanted at the L4-L5 segment using virtual FEM. A 400 N compressive force combined with 6 N flexion, extension, bending and axial rotation forces was applied to the L3-4 and L4-5 segments. ROM and disc loading forces were analyzed. Both systems reduced ROM and disc loading forces at the implanted lumbar segment, with the exception of the Coflex interspinous device, which increased ROM by 19% and did not change disc-loading forces in flexion. The Coflex device prevented excessive disc loading, but increased ROM abnormally in flexion. Neither device provided satisfactory motion preservation or load sharing in other directions. Copyright © 2015 John Wiley & Sons, Ltd.

Effect of residual stresses induced by prestressing on rolling element fatigue life

NASA Technical Reports Server (NTRS)

Parker, R. J.; Zaretsky, E. V.

1972-01-01

A mechanical prestress cycle suitable to induce compressive stress beneath the surface of the inner race of radially loaded 207-size bearings was determined. Compressive residual stress in excess 0.69 x 10 to the 9th power N/sq m (100,000 psi), as measured by X-ray diffraction, were induced at the depth of maximum shearing stress. The prestress cycle consisted of running the bearings for 25 hours at 2750 rpm at a radial load which produced a maximum Hertz stress of 3.3 x 10 to the 9th power N/sq m (480,000 psi) at the contact of the inner race and the heaviest loaded ball. Bearings subjected to this prestress cycle and subsequently fatigue tested gave a 10 percent fatigue life greater than twice that of a group of baseline bearings.

(LBA-and-WRM)-based DBA scheme for multi-wavelength upstream transmission supporting 10 Gbps and 1 Gbps in MAN

NASA Astrophysics Data System (ADS)

Zhang, Yuchao; Gan, Chaoqin; Gou, Kaiyu; Xu, Anni; Ma, Jiamin

2018-01-01

DBA scheme based on Load balance algorithm (LBA) and wavelength recycle mechanism (WRM) for multi-wavelength upstream transmission is proposed in this paper. According to 1 Gbps and 10 Gbps line rates, ONUs are grouped into different VPONs. To facilitate wavelength management, resource pool is proposed to record wavelength state. To realize quantitative analysis, a mathematical model describing metro-access network (MAN) environment is presented. To 10G-EPON upstream, load balance algorithm is designed to ensure load distribution fairness for 10G-OLTs. To 1G-EPON upstream, wavelength recycle mechanism is designed to share remained wavelengths. Finally, the effectiveness of the proposed scheme is demonstrated by simulation and analysis.

Exercise and Asthma

MedlinePlus

... Treatments ▸ Library ▸ Asthma Library ▸ Exercise and Asthma Share | Exercise and Asthma This article has been reviewed by Thanai Pongdee, MD, FAAAAI Exercise-induced bronchoconstriction (EIB) , also called exercise-induced asthma, ...

Effects of Second-Order Hydrodynamics on a Semisubmersible Floating Offshore Wind Turbine: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bayati, I.; Jonkman, J.; Robertson, A.

2014-07-01

The objective of this paper is to assess the second-order hydrodynamic effects on a semisubmersible floating offshore wind turbine. Second-order hydrodynamics induce loads and motions at the sum- and difference-frequencies of the incident waves. These effects have often been ignored in offshore wind analysis, under the assumption that they are significantly smaller than first-order effects. The sum- and difference-frequency loads can, however, excite eigenfrequencies of the system, leading to large oscillations that strain the mooring system or vibrations that cause fatigue damage to the structure. Observations of supposed second-order responses in wave-tank tests performed by the DeepCwind consortium at themore » MARIN offshore basin suggest that these effects might be more important than originally expected. These observations inspired interest in investigating how second-order excitation affects floating offshore wind turbines and whether second-order hydrodynamics should be included in offshore wind simulation tools like FAST in the future. In this work, the effects of second-order hydrodynamics on a floating semisubmersible offshore wind turbine are investigated. Because FAST is currently unable to account for second-order effects, a method to assess these effects was applied in which linearized properties of the floating wind system derived from FAST (including the 6x6 mass and stiffness matrices) are used by WAMIT to solve the first- and second-order hydrodynamics problems in the frequency domain. The method has been applied to the OC4-DeepCwind semisubmersible platform, supporting the NREL 5-MW baseline wind turbine. The loads and response of the system due to the second-order hydrodynamics are analysed and compared to first-order hydrodynamic loads and induced motions in the frequency domain. Further, the second-order loads and induced response data are compared to the loads and motions induced by aerodynamic loading as solved by FAST.« less

Targeting focal adhesion kinase with small interfering RNA prevents and reverses load-induced cardiac hypertrophy in mice.

PubMed

Clemente, Carolina F M Z; Tornatore, Thais F; Theizen, Thais H; Deckmann, Ana C; Pereira, Tiago C; Lopes-Cendes, Iscia; Souza, José Roberto M; Franchini, Kleber G

2007-12-07

Hypertrophy is a critical event in the onset of failure in chronically overloaded hearts. Focal adhesion kinase (FAK) has attracted particular attention as a mediator of hypertrophy induced by increased load. Here, we demonstrate increased expression and phosphorylation of FAK in the hypertrophic left ventricles (LVs) of aortic-banded mice. We used an RNA interference strategy to examine whether FAK signaling plays a role in the pathophysiology of load-induced LV hypertrophy and failure. Intrajugular delivery of specific small interfering RNA induced prolonged FAK silencing ( approximately 70%) in both normal and hypertrophic LVs. Myocardial FAK silencing was accompanied by prevention, as well as reversal, of load-induced left ventricular hypertrophy. The function of LVs was preserved and the survival rate was higher in banded mice treated with small interfering RNA targeted to FAK, despite the persistent pressure overload. Studies in cardiac myocytes and fibroblasts harvested from LVs confirmed the ability of the systemically administered specific small interfering RNA to silence FAK in both cell types. Further analysis indicated attenuation of cardiac myocyte hypertrophic growth and of the rise in the expression of beta-myosin heavy chain in overloaded LVs. Moreover, FAK silencing was demonstrated to attenuate the rise in the fibrosis, collagen content, and activity of matrix metalloproteinase-2 in overloaded LVs, as well as the rise of matrix metalloproteinase-2 protein expression in fibroblasts harvested from overloaded LVs. This study provides novel evidence that FAK may be involved in multiple aspects of the pathophysiology of cardiac hypertrophy and failure induced by pressure overload.

Simulation of Human-induced Vibrations Based on the Characterized In-field Pedestrian Behavior

PubMed Central

Van Nimmen, Katrien; Lombaert, Geert; De Roeck, Guido; Van den Broeck, Peter

2016-01-01

For slender and lightweight structures, vibration serviceability is a matter of growing concern, often constituting the critical design requirement. With designs governed by the dynamic performance under human-induced loads, a strong demand exists for the verification and refinement of currently available load models. The present contribution uses a 3D inertial motion tracking technique for the characterization of the in-field pedestrian behavior. The technique is first tested in laboratory experiments with simultaneous registration of the corresponding ground reaction forces. The experiments include walking persons as well as rhythmical human activities such as jumping and bobbing. It is shown that the registered motion allows for the identification of the time variant pacing rate of the activity. Together with the weight of the person and the application of generalized force models available in literature, the identified time-variant pacing rate allows to characterize the human-induced loads. In addition, time synchronization among the wireless motion trackers allows identifying the synchronization rate among the participants. Subsequently, the technique is used on a real footbridge where both the motion of the persons and the induced structural vibrations are registered. It is shown how the characterized in-field pedestrian behavior can be applied to simulate the induced structural response. It is demonstrated that the in situ identified pacing rate and synchronization rate constitute an essential input for the simulation and verification of the human-induced loads. The main potential applications of the proposed methodology are the estimation of human-structure interaction phenomena and the development of suitable models for the correlation among pedestrians in real traffic conditions. PMID:27167309

Analgesic effects of carprofen and liposome-encapsulated butorphanol tartrate in Hispaniolan parrots (Amazona ventralis) with experimentally induced arthritis.

PubMed

Paul-Murphy, Joanne R; Sladky, Kurt K; Krugner-Higby, Lisa A; Stading, Ben R; Klauer, Julia M; Keuler, Nicholas S; Brown, Carolyn S; Heath, Timothy D

2009-10-01

To evaluate the microcrystalline sodium urate (MSU) method for inducing arthritis in parrots and to compare the analgesic efficacy of long-acting liposome-encapsulated butorphanol (LEBT), carprofen, or a combination of both. 20 Hispaniolan parrots. MSU was injected into a tibiotarsal-tarsometatarsal (intertarsal) joint to induce arthritis (time 0). Four treatments were compared (LEBT [15 mg/kg, SC] administered once at time 0; injections of carprofen [3 mg/kg, IM, q 12 h] starting at time 0; administration of LEBT plus carprofen; and a control treatment of saline [0.9% NaCl] solution). Weight load testing and behavioral scoring were conducted at 0, 2, 6, 26, and 30 hours. Injection of MSU into the intertarsal joint induced arthritis, which resolved within 30 hours. Treatment with LEBT or LEBT plus carprofen resulted in significantly greater weight-bearing load on the limb with induced arthritis, compared with the control treatment. Treatment with carprofen alone caused a slight but nonsignificant improvement in weight-bearing load on the arthritic limb, compared with the control treatment. Behaviors associated with motor activity and weight bearing differed between the control and analgesic treatments. Butorphanol was an effective treatment for pain associated with arthritis, but carprofen administered every 12 hours was insufficient. Injection of MSU to induce arthritis in a single joint was a good method for evaluating tonic pain in parrots, and measurement of the weight-bearing load was accurate for assessment of arthritic pain; however, behavioral changes associated with pain were subtle.

Strain features and condition assessment of orthotropic steel deck cable-supported bridges subjected to vehicle loads by using dense FBG strain sensors

NASA Astrophysics Data System (ADS)

Wei, Shiyin; Zhang, Zhaohui; Li, Shunlong; Li, Hui

2017-10-01

Strain is a direct indicator of structural safety. Therefore, strain sensors have been used in most structural health monitoring systems for bridges. However, until now, the investigation of strain response has been insufficient. This paper conducts a comprehensive study of the strain features of the U ribs and transverse diaphragm on an orthotropic steel deck and proposes a statistical paradigm for crack detection based on the features of vehicle-induced strain response by using the densely distributed optic fibre Bragg grating (FBG) strain sensors. The local feature of strain under vehicle load is highlighted, which enables the use of measurement data to determine the vehicle loading event and to make a decision regarding the health status of a girder near the strain sensors via technical elimination of the load information. Time-frequency analysis shows that the strain contains three features: the long-term trend item, the short-term trend item, and the instantaneous vehicle-induced item (IVII). The IVII is the wheel-induced strain with a remarkable local feature, and the measured wheel-induced strain is only influenced by the vehicle near the FBG sensor, while other vehicles slightly farther away have no effect on the wheel-induced strain. This causes the local strain series, among the FBG strain sensors in the same transverse locations of different cross-sections, to present similarities in shape to some extent and presents a time delay in successive order along the driving direction. Therefore, the strain series induced by an identical vehicle can be easily tracked and compared by extracting the amplitude and calculating the mutual ratio to eliminate vehicle loading information, leaving the girder information alone. The statistical paradigm for crack detection is finally proposed, and the detection accuracy is then validated by using dense FBG strain sensors on a long-span suspension bridge in China.

Graphemes Sharing Phonetic Features Tend to Induce Similar Synesthetic Colors.

PubMed

Kang, Mi-Jeong; Kim, Yeseul; Shin, Ji-Young; Kim, Chai-Youn

2017-01-01

Individuals with grapheme-color synesthesia experience idiosyncratic colors when viewing achromatic letters or digits. Despite large individual differences in grapheme-color association, synesthetes tend to associate graphemes sharing a perceptual feature with similar synesthetic colors. Sound has been suggested as one such feature. In the present study, we investigated whether graphemes of which representative phonemes have similar phonetic features tend to be associated with analogous synesthetic colors. We tested five Korean multilingual synesthetes on a color-matching task using graphemes from Korean, English, and Japanese orthography. We then compared the similarity of synesthetic colors induced by those characters sharing a phonetic feature. Results showed that graphemes associated with the same phonetic feature tend to induce synesthetic color in both within- and cross-script analyses. Moreover, this tendency was consistent for graphemes that are not transliterable into each other as well as graphemes that are. These results suggest that it is the perceptual-i.e., phonetic-properties associated with graphemes, not just conceptual associations such as transliteration, that determine synesthetic color.

Graphemes Sharing Phonetic Features Tend to Induce Similar Synesthetic Colors

PubMed Central

Kang, Mi-Jeong; Kim, Yeseul; Shin, Ji-Young; Kim, Chai-Youn

2017-01-01

Individuals with grapheme-color synesthesia experience idiosyncratic colors when viewing achromatic letters or digits. Despite large individual differences in grapheme-color association, synesthetes tend to associate graphemes sharing a perceptual feature with similar synesthetic colors. Sound has been suggested as one such feature. In the present study, we investigated whether graphemes of which representative phonemes have similar phonetic features tend to be associated with analogous synesthetic colors. We tested five Korean multilingual synesthetes on a color-matching task using graphemes from Korean, English, and Japanese orthography. We then compared the similarity of synesthetic colors induced by those characters sharing a phonetic feature. Results showed that graphemes associated with the same phonetic feature tend to induce synesthetic color in both within- and cross-script analyses. Moreover, this tendency was consistent for graphemes that are not transliterable into each other as well as graphemes that are. These results suggest that it is the perceptual—i.e., phonetic—properties associated with graphemes, not just conceptual associations such as transliteration, that determine synesthetic color. PMID:28348537

Global Cryptosporidium Loads from Livestock Manure.

PubMed

Vermeulen, Lucie C; Benders, Jorien; Medema, Gertjan; Hofstra, Nynke

2017-08-01

Understanding the environmental pathways of Cryptosporidium is essential for effective management of human and animal cryptosporidiosis. In this paper we aim to quantify livestock Cryptosporidium spp. loads to land on a global scale using spatially explicit process-based modeling, and to explore the effect of manure storage and treatment on oocyst loads using scenario analysis. Our model GloWPa-Crypto L1 calculates a total global Cryptosporidium spp. load from livestock manure of 3.2 × 10 23 oocysts per year. Cattle, especially calves, are the largest contributors, followed by chickens and pigs. Spatial differences are linked to animal spatial distributions. North America, Europe, and Oceania together account for nearly a quarter of the total oocyst load, meaning that the developing world accounts for the largest share. GloWPa-Crypto L1 is most sensitive to oocyst excretion rates, due to large variation reported in literature. We compared the current situation to four alternative management scenarios. We find that although manure storage halves oocyst loads, manure treatment, especially of cattle manure and particularly at elevated temperatures, has a larger load reduction potential than manure storage (up to 4.6 log units). Regions with high reduction potential include India, Bangladesh, western Europe, China, several countries in Africa, and New Zealand.

Dynamic Load-Balancing for Distributed Heterogeneous Computing of Parallel CFD Problems

NASA Technical Reports Server (NTRS)

Ecer, A.; Chien, Y. P.; Boenisch, T.; Akay, H. U.

2000-01-01

The developed methodology is aimed at improving the efficiency of executing block-structured algorithms on parallel, distributed, heterogeneous computers. The basic approach of these algorithms is to divide the flow domain into many sub- domains called blocks, and solve the governing equations over these blocks. Dynamic load balancing problem is defined as the efficient distribution of the blocks among the available processors over a period of several hours of computations. In environments with computers of different architecture, operating systems, CPU speed, memory size, load, and network speed, balancing the loads and managing the communication between processors becomes crucial. Load balancing software tools for mutually dependent parallel processes have been created to efficiently utilize an advanced computation environment and algorithms. These tools are dynamic in nature because of the chances in the computer environment during execution time. More recently, these tools were extended to a second operating system: NT. In this paper, the problems associated with this application will be discussed. Also, the developed algorithms were combined with the load sharing capability of LSF to efficiently utilize workstation clusters for parallel computing. Finally, results will be presented on running a NASA based code ADPAC to demonstrate the developed tools for dynamic load balancing.

Creep and cracking of concrete hinges: insight from centric and eccentric compression experiments.

PubMed

Schlappal, Thomas; Schweigler, Michael; Gmainer, Susanne; Peyerl, Martin; Pichler, Bernhard

2017-01-01

Existing design guidelines for concrete hinges consider bending-induced tensile cracking, but the structural behavior is oversimplified to be time-independent. This is the motivation to study creep and bending-induced tensile cracking of initially monolithic concrete hinges systematically. Material tests on plain concrete specimens and structural tests on marginally reinforced concrete hinges are performed. The experiments characterize material and structural creep under centric compression as well as bending-induced tensile cracking and the interaction between creep and cracking of concrete hinges. As for the latter two aims, three nominally identical concrete hinges are subjected to short-term and to longer-term eccentric compression tests. Obtained material and structural creep functions referring to centric compression are found to be very similar. The structural creep activity under eccentric compression is significantly larger because of the interaction between creep and cracking, i.e. bending-induced cracks progressively open and propagate under sustained eccentric loading. As for concrete hinges in frame-like integral bridge construction, it is concluded (i) that realistic simulation of variable loads requires consideration of the here-studied time-dependent behavior and (ii) that permanent compressive normal forces shall be limited by 45% of the ultimate load carrying capacity, in order to avoid damage of concrete hinges under sustained loading.

Apatinib-loaded nanoparticles suppress vascular endothelial growth factor-induced angiogenesis and experimental corneal neovascularization.

PubMed

Lee, Jung Eun; Kim, Koung Li; Kim, Danbi; Yeo, Yeongju; Han, Hyounkoo; Kim, Myung Goo; Kim, Sun Hwa; Kim, Hyuncheol; Jeong, Ji Hoon; Suh, Wonhee

2017-01-01

Pathological angiogenesis is one of the major symptoms of severe ocular diseases, including corneal neovascularization. The blockade of vascular endothelial growth factor (VEGF) action has been recognized as an efficient strategy for treating corneal neovascularization. In this study, we aimed to investigate whether nanoparticle-based delivery of apatinib, a novel and selective inhibitor of VEGF receptor 2, inhibits VEGF-mediated angiogenesis and suppresses experimental corneal neovascularization. Water-insoluble apatinib was encapsulated in nanoparticles composed of human serum albumin (HSA)-conjugated polyethylene glycol (PEG). In vitro angiogenesis assays showed that apatinib-loaded HSA-PEG (Apa-HSA-PEG) nanoparticles potently inhibited VEGF-induced tube formation, scratch wounding migration, and proliferation of human endothelial cells. In a rat model of alkali burn injury-induced corneal neovascularization, a subconjunctival injection of Apa-HSA-PEG nanoparticles induced a significant decrease in neovascularization compared to that observed with an injection of free apatinib solution or phosphate-buffered saline. An in vivo distribution study using HSA-PEG nanoparticles loaded with fluorescent hydrophobic model drugs revealed the presence of a substantial number of nanoparticles in the corneal stroma within 24 h after injection. These in vitro and in vivo results demonstrate that apatinib-loaded nanoparticles may be promising for the prevention and treatment of corneal neovascularization-related ocular disorders.

Apatinib-loaded nanoparticles suppress vascular endothelial growth factor-induced angiogenesis and experimental corneal neovascularization

PubMed Central

Lee, Jung Eun; Kim, Koung Li; Kim, Danbi; Yeo, Yeongju; Han, Hyounkoo; Kim, Myung Goo; Kim, Sun Hwa; Kim, Hyuncheol; Jeong, Ji Hoon; Suh, Wonhee

2017-01-01

Pathological angiogenesis is one of the major symptoms of severe ocular diseases, including corneal neovascularization. The blockade of vascular endothelial growth factor (VEGF) action has been recognized as an efficient strategy for treating corneal neovascularization. In this study, we aimed to investigate whether nanoparticle-based delivery of apatinib, a novel and selective inhibitor of VEGF receptor 2, inhibits VEGF-mediated angiogenesis and suppresses experimental corneal neovascularization. Water-insoluble apatinib was encapsulated in nanoparticles composed of human serum albumin (HSA)-conjugated polyethylene glycol (PEG). In vitro angiogenesis assays showed that apatinib-loaded HSA-PEG (Apa-HSA-PEG) nanoparticles potently inhibited VEGF-induced tube formation, scratch wounding migration, and proliferation of human endothelial cells. In a rat model of alkali burn injury-induced corneal neovascularization, a subconjunctival injection of Apa-HSA-PEG nanoparticles induced a significant decrease in neovascularization compared to that observed with an injection of free apatinib solution or phosphate-buffered saline. An in vivo distribution study using HSA-PEG nanoparticles loaded with fluorescent hydrophobic model drugs revealed the presence of a substantial number of nanoparticles in the corneal stroma within 24 h after injection. These in vitro and in vivo results demonstrate that apatinib-loaded nanoparticles may be promising for the prevention and treatment of corneal neovascularization-related ocular disorders. PMID:28740387

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway.

PubMed

Fineran, Paul; Lloyd-Evans, Emyr; Lack, Nathan A; Platt, Nick; Davis, Lianne C; Morgan, Anthony J; Höglinger, Doris; Tatituri, Raju Venkata V; Clark, Simon; Williams, Ian M; Tynan, Patricia; Al Eisa, Nada; Nazarova, Evgeniya; Williams, Ann; Galione, Antony; Ory, Daniel S; Besra, Gurdyal S; Russell, David G; Brenner, Michael B; Sim, Edith; Platt, Frances M

2016-11-18

Tuberculosis remains a major global health concern. The ability to prevent phagosome-lysosome fusion is a key mechanism by which intracellular mycobacteria, including Mycobacterium tuberculosis , achieve long-term persistence within host cells. The mechanisms underpinning this key intracellular pro-survival strategy remain incompletely understood. Host macrophages infected with persistent mycobacteria share phenotypic similarities with cells taken from patients suffering from Niemann-Pick Disease Type C (NPC), a rare lysosomal storage disease in which endocytic trafficking defects and lipid accumulation within the lysosome lead to cell dysfunction and cell death. We investigated whether these shared phenotypes reflected an underlying mechanistic connection between mycobacterial intracellular persistence and the host cell pathway dysfunctional in NPC. The induction of NPC phenotypes in macrophages from wild-type mice or obtained from healthy human donors was assessed via infection with mycobacteria and subsequent measurement of lipid levels and intracellular calcium homeostasis. The effect of NPC therapeutics on intracellular mycobacterial load was also assessed. Macrophages infected with persistent intracellular mycobacteria phenocopied NPC cells, exhibiting accumulation of multiple lipid types, reduced lysosomal Ca 2+ levels, and defects in intracellular trafficking. These NPC phenotypes could also be induced using only lipids/glycomycolates from the mycobacterial cell wall. These data suggest that persistent intracellular mycobacteria inhibit the NPC pathway, likely via inhibition of the NPC1 protein, and subsequently induce altered acidic store Ca 2+ homeostasis. Reduced lysosomal calcium levels may provide a mechanistic explanation for the reduced levels of phagosome-lysosome fusion in mycobacterial infection. Treatments capable of correcting defects in NPC mutant cells via modulation of host cell calcium were of benefit in promoting clearance of mycobacteria from infected host cells. These findings provide a novel mechanistic explanation for mycobacterial intracellular persistence, and suggest that targeting interactions between the mycobacteria and host cell pathways may provide a novel avenue for development of anti-TB therapies.

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway

PubMed Central

Fineran, Paul; Lloyd-Evans, Emyr; Lack, Nathan A.; Platt, Nick; Davis, Lianne C.; Morgan, Anthony J.; Höglinger, Doris; Tatituri, Raju Venkata V.; Clark, Simon; Williams, Ian M.; Tynan, Patricia; Al Eisa, Nada; Nazarova, Evgeniya; Williams, Ann; Galione, Antony; Ory, Daniel S.; Besra, Gurdyal S.; Russell, David G.; Brenner, Michael B.; Sim, Edith; Platt, Frances M.

2017-01-01

Background. Tuberculosis remains a major global health concern. The ability to prevent phagosome-lysosome fusion is a key mechanism by which intracellular mycobacteria, including Mycobacterium tuberculosis, achieve long-term persistence within host cells. The mechanisms underpinning this key intracellular pro-survival strategy remain incompletely understood. Host macrophages infected with intracellular mycobacteria share phenotypic similarities with cells taken from patients suffering from Niemann-Pick Disease Type C (NPC), a rare lysosomal storage disease in which endocytic trafficking defects and lipid accumulation within the lysosome lead to cell dysfunction and cell death. We investigated whether these shared phenotypes reflected an underlying mechanistic connection between mycobacterial intracellular persistence and the host cell pathway dysfunctional in NPC.  Methods. The induction of NPC phenotypes in macrophages from wild-type mice or obtained from healthy human donors was assessed via infection with mycobacteria and subsequent measurement of lipid levels and intracellular calcium homeostasis. The effect of NPC therapeutics on intracellular mycobacterial load was also assessed.  Results. Macrophages infected with intracellular mycobacteria phenocopied NPC cells, exhibiting accumulation of multiple lipid types, reduced lysosomal Ca 2+ levels, and defects in intracellular trafficking. These NPC phenotypes could also be induced using only lipids/glycomycolates from the mycobacterial cell wall. These data suggest that intracellular mycobacteria inhibit the NPC pathway, likely via inhibition of the NPC1 protein, and subsequently induce altered acidic store Ca 2+ homeostasis. Reduced lysosomal calcium levels may provide a mechanistic explanation for the reduced levels of phagosome-lysosome fusion in mycobacterial infection. Treatments capable of correcting defects in NPC mutant cells via modulation of host cell calcium were of benefit in promoting clearance of mycobacteria from infected host cells.  Conclusion. These findings provide a novel mechanistic explanation for mycobacterial intracellular persistence, and suggest that targeting interactions between the mycobacteria and host cell pathways may provide a novel avenue for development of anti-TB therapies. PMID:28008422

Evaluation of the antitumor effect of dexamethasone palmitate and doxorubicin co-loaded liposomes modified with a sialic acid-octadecylamine conjugate.

PubMed

Sun, Jing; Song, Yanzhi; Lu, Mei; Lin, Xiangyun; Liu, Yang; Zhou, Songlei; Su, Yuqing; Deng, Yihui

2016-10-10

Dexamethasone palmitate has the potential to inhibit the activity of tumor-associated macrophages, which promote cancer proliferation, invasion, and metastasis; however, only very high and frequent doses are capable of inducing antitumor effects. With the aim to reduce the anticancer dose and decrease the nonspecific toxicity, we designed a liposomal system to co-deliver dexamethasone palmitate and doxorubicin. Furthermore, a ligand conjugate sialic acid-octadecylamine, with enhanced affinity towards the membrane receptors over-expressed in tumors, was anchored on the surface of the liposomes to increase drug distribution to the tumor tissue. Co-loaded liposomes were developed using lipid film hydration method to load dexamethasone palmitate and remote loading technology to load doxorubicin. The co-loaded liposomes modified with sialic acid-octadecylamine represented comparable physicochemical properties and blood plasma profiles with conventional co-loaded liposomes, but the biodistribution proved that sialic acid-octadecylamine modified liposomes accumulated more in tumor. The co-loaded liposomes showed higher tumor growth suppression than the single-drug loaded liposomes, while showing no additional drug toxicity in S180-bearing Kunming mice. The co-loaded liposomes modified with sialic acid-octadecylamine achieved a significantly better antitumor effect, and induced "shedding" of cancerous tissue in the mice. These finding suggested that co-loaded liposomes modified with sialic acid-octadecylamine provided a safe therapeutic strategy with outstanding anticancer activity. Copyright © 2016 Elsevier B.V. All rights reserved.

Biomechanical influence of disk properties on the load transfer of healthy and degenerated disks using a poroelastic finite element model.

PubMed

Chagnon, Amélie; Aubin, Carl-Eric; Villemure, Isabelle

2010-11-01

Spine degeneration is a pathology that will affect 80% of the population. Since the intervertebral disks play an important role in transmitting loads through the spine, the aim of this study was to evaluate the biomechanical impact of disk properties on the load carried by healthy (Thompson grade I) and degenerated (Thompson grades III and IV) disks. A three-dimensional parametric poroelastic finite element model of the L4/L5 motion segment was developed. Grade I, grade II, and grade IV disks were modeled by altering the biomechanical properties of both the annulus and nucleus. Models were validated using published creep experiments, in which a constant compressive axial stress of 0.35 MPa was applied for 4 h. Pore pressure (PP) and effective stress (S(E)) were analyzed as a function of time following loading application (1 min, 5 min, 45 min, 125 min, and 245 min) and discal region along the midsagittal profile for each disk grade. A design of experiments was further implemented to analyze the influence of six disk parameters (disk height (H), fiber proportion (%F), drained Young's modulus (E(a),E(n)), and initial permeability (k(a),k(n)) of both the annulus and nucleus) on load-sharing for disk grades I and IV. Simulations of grade I, grade III, and grade IV disks agreed well with the available published experimental data. Disk height (H) had a significant influence (p<0.05) on the PP and S(E) during the entire loading history for both healthy and degenerated disk models. Young's modulus of the annulus (E(a)) significantly affected not only S(E) in the annular region for both disk grades in the initial creep response but also S(E) in the nucleus zone for degenerated disks with further creep response. The nucleus and annulus permeabilities had a significant influence on the PP distribution for both disk grades, but this effect occurred at earlier stages of loading for degenerated than for healthy disk models. This is the first study that investigates the biomechanical influence of both geometrical and material disk properties on the load transfer of healthy and degenerated disks. Disk height is a significant parameter for both healthy and degenerated disks during the entire loading. Changes in the annulus stiffness, as well as in the annulus and nucleus permeability, control load-sharing in different ways for healthy and degenerated disks.

Trailing Vortex-Induced Loads During Close Encounters in Cruise

NASA Technical Reports Server (NTRS)

Mendenhall, Michael R.; Lesieutre, Daniel J; Kelly, Michael J.

2015-01-01

The trailing vortex induced aerodynamic loads on a Falcon 20G business jet flying in the wake of a DC-8 are predicted to provide a preflight estimate of safe trail distances during flight test measurements in the wake. Static and dynamic loads on the airframe flying in the near wake are shown at a matrix of locations, and the dynamic motion of the Falcon 20G during traverses of the DC-8 primary trailing vortex is simulated. Safe trailing distances for the test flights are determined, and optimum vortex traverse schemes are identified to moderate the motion of the trailing aircraft during close encounters with the vortex wake.

Functional testing of space flight induced changes in tonic motor control by using limb-attached excitation and load devices

NASA Astrophysics Data System (ADS)

Gallasch, Eugen; Kozlovskaya, Inessa

2007-02-01

Long term space flights induce atrophy and contractile changes on postural muscles such effecting tonic motor control. Functional testing of tonic motor control structures is a challenge because of the difficulties to deliver appropriate test forces on crew members. In this paper we propose two approaches for functional testing by using limb attached loading devices. The first approach is based on a frequency and amplitude controllable moving magnet exciter to deliver sinusoidal test forces during limb postures. The responding limb deflection is recorded by an embedded accelerometer to obtain limb impedance. The second approach is based on elastic limb loading to evoke self-excited oscillations during arm extensions. Here the contraction force at the oscillation onset provides information about limb stiffness. The rationale for both testing approaches is based on Feldman's λ-model. An arm expander based on the second approach was probed in a 6-month MIR space flight. The results obtained from the load oscillations, confirmed that this device is well suited to capture space flight induced neuromuscular changes.

Residual-stress-induced grain growth of twinned grains and its effect on formability of magnesium alloy sheet at room temperature

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Se-Jong; Kim, Daeyong, E-mail: daeyong@kims.re.kr; Lee, Keunho

2015-11-15

A magnesium alloy sheet was subjected to in-plane compression along with a vertical load to avoid buckling during compression. Pre-compressed specimens machined from the sheet were annealed at different temperatures and the changes in microstructure and texture were observed using electron back scattered diffraction (EBSD). Twinned grains preferentially grew during annealing at 300 °C, so that a strong texture with the < 0001 > direction parallel to the transverse direction developed. EBSD analysis confirmed that the friction caused by the vertical load induced inhomogeneous distribution of residual stress, which acted as an additional driving force for preferential grain growth ofmore » twinned grain during annealing. The annealed specimen showed excellent formability. - Highlights: • A magnesium alloy sheet subjected to in-plane compression under a vertical load • The vertical load induced inhomogeneous distribution of the residual stress. • The residual stress acted as an additional driving force for grain growth. • The annealed specimen with strong non-basal texture showed excellent formability.« less

Leaf extract of Wasabia japonica relieved oxidative stress induced by Helicobacter pylori infection and stress loading in Mongolian gerbils.

PubMed

Sekiguchi, Hirotaka; Takabayashi, Fumiyo; Deguchi, Yuya; Masuda, Hideki; Toyoizumi, Tomoyasu; Masuda, Shuichi; Kinae, Naohide

2010-01-01

Infection with Helicobacter pylori (H. pylori) can induce gastric disorders, and though its presence cannot explain disease pathogenesis and does not have associations with other factors, it is well known that H. pylori infection causes stomach inflammation following oxidative stress. We examined the suppressive effects of a leaf extract of Wasabia japonica on H. pylori infection and on stress loading in Mongolian gerbils. Following oral administration of wasabi extract of 50 and 200 mg/kg B.W./d for 10 d, the animals were exposed to restraint stress for 90 and 270 min. As for the results, the level of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in the stomach and oxidative DNA damage in peripheral erythrocytes at 270 min significantly increased. That elevation was significantly suppressed by the addition of the leaf extract. We concluded that the simultaneous loading of H. pylori infection and physical stress loading might induce oxidative DNA damage additively, while a leaf extract attenuated this DNA damage in the stomach as well as the peripheral erythrocytes.

Dynamic hydraulic fluid stimulation regulated intramedullary pressure.

PubMed

Hu, Minyi; Serra-Hsu, Frederick; Bethel, Neville; Lin, Liangjun; Ferreri, Suzanne; Cheng, Jiqi; Qin, Yi-Xian

2013-11-01

Physical signals within the bone, i.e. generated from mechanical loading, have the potential to initiate skeletal adaptation. Strong evidence has pointed to bone fluid flow (BFF) as a media between an external load and the bone cells, in which altered velocity and pressure can ultimately initiate the mechanotransduction and the remodeling process within the bone. Load-induced BFF can be altered by factors such as intramedullary pressure (ImP) and/or bone matrix strain, mediating bone adaptation. Previous studies have shown that BFF induced by ImP alone, with minimum bone strain, can initiate bone remodeling. However, identifying induced ImP dynamics and bone strain factor in vivo using a non-invasive method still remains challenging. To apply ImP as a means for alteration of BFF, it was hypothesized that non-invasive dynamic hydraulic stimulation (DHS) can induce local ImP with minimal bone strain to potentially elicit osteogenic adaptive responses via bone-muscle coupling. The goal of this study was to evaluate the immediate effects on local and distant ImP and strain in response to a range of loading frequencies using DHS. Simultaneous femoral and tibial ImP and bone strain values were measured in three 15-month-old female Sprague Dawley rats during DHS loading on the tibia with frequencies of 1Hz to 10Hz. DHS showed noticeable effects on ImP induction in the stimulated tibia in a nonlinear fashion in response to DHS over the range of loading frequencies, where they peaked at 2Hz. DHS at various loading frequencies generated minimal bone strain in the tibiae. Maximal bone strain measured at all loading frequencies was less than 8με. No detectable induction of ImP or bone strain was observed in the femur. This study suggested that oscillatory DHS may regulate the local fluid dynamics with minimal mechanical strain in the bone, which serves critically in bone adaptation. These results clearly implied DHS's potential as an effective, non-invasive intervention for osteopenia and osteoporosis treatments. © 2013. Published by Elsevier Inc. All rights reserved.

Optimal load scheduling in commercial and residential microgrids

NASA Astrophysics Data System (ADS)

Ganji Tanha, Mohammad Mahdi

Residential and commercial electricity customers use more than two third of the total energy consumed in the United States, representing a significant resource of demand response. Price-based demand response, which is in response to changes in electricity prices, represents the adjustments in load through optimal load scheduling (OLS). In this study, an efficient model for OLS is developed for residential and commercial microgrids which include aggregated loads in single-units and communal loads. Single unit loads which include fixed, adjustable and shiftable loads are controllable by the unit occupants. Communal loads which include pool pumps, elevators and central heating/cooling systems are shared among the units. In order to optimally schedule residential and commercial loads, a community-based optimal load scheduling (CBOLS) is proposed in this thesis. The CBOLS schedule considers hourly market prices, occupants' comfort level, and microgrid operation constraints. The CBOLS' objective in residential and commercial microgrids is the constrained minimization of the total cost of supplying the aggregator load, defined as the microgrid load minus the microgrid generation. This problem is represented by a large-scale mixed-integer optimization for supplying single-unit and communal loads. The Lagrangian relaxation methodology is used to relax the linking communal load constraint and decompose the independent single-unit functions into subproblems which can be solved in parallel. The optimal solution is acceptable if the aggregator load limit and the duality gap are within the bounds. If any of the proposed criteria is not satisfied, the Lagrangian multiplier will be updated and a new optimal load schedule will be regenerated until both constraints are satisfied. The proposed method is applied to several case studies and the results are presented for the Galvin Center load on the 16th floor of the IIT Tower in Chicago.

Colony-level variation in pollen collection and foraging preferences among wild-caught bumble bees (Hymenoptera: Apidae).

PubMed

Saifuddin, Mustafa; Jha, Shalene

2014-04-01

Given that many pollinators have exhibited dramatic declines related to habitat destruction, an improved understanding of pollinator resource collection across human-altered landscapes is essential to conservation efforts. Despite the importance of bumble bees (Bombus spp.) as global pollinators, little is known regarding how pollen collection patterns vary between individuals, colonies, and landscapes. In this study, Vosnesensky bumble bees (Bombus vosnesenskii Radoszkowski) were collected from a range of human-altered and natural landscapes in northern California. Extensive vegetation surveys and Geographic Information System (GIS)-based habitat classifications were conducted at each site, bees were genotyped to identify colony mates, and pollen loads were examined to identify visited plants. In contrast to predictions based on strong competitive interactions, pollen load composition was significantly more similar for bees captured in a shared study region compared with bees throughout the research area but was not significantly more similar for colony mates. Preference analyses revealed that pollen loads were not composed of the most abundant plant species per study region. The majority of ranked pollen preference lists were significantly correlated for pairwise comparisons of colony mates and individuals within a study region, whereas the majority of pairwise comparisons of ranked pollen preference lists between individuals located at separate study regions were uncorrelated. Results suggest that pollen load composition and foraging preferences are similar for bees throughout a shared landscape regardless of colony membership. The importance of native plant species in pollen collection is illustrated through preference analyses, and we suggest prioritization of specific rare native plant species for enhanced bumble bee pollen collection.

Effectiveness of centrifuge-induced artificial gravity with ergometric exercise as a countermeasure during simulated microgravity exposure in humans.

PubMed

Iwase, Satoshi

2005-01-01

To test the effectiveness of centrifuge-induced artificial gravity with ergometric exercise, 12 healthy young men (20.7 +/- 1.9 yr) were exposed to simulated microgravity for 14 days of -6 degrees head-down bedrest. Half the subjects were randomly selected and loaded 1.2 G artificial gravity with 60 W (four out of six subjects) or 40 W (two out of six subjects) of ergometric workload on days 1, 2, 3, 5, 7, 9, 11, 12, 13, 14 (CM group). The rest of the subjects served as the control. Anti-G score, defined as the G-load x running time to the endpoint, was significantly elongated by the load of the centrifuge-ergometer. Plasma volume loss was suppressed (-5.0 +/- 2.4 vs. -16.4 +/- 1.9%), and fluid volume shift was prevented by the countermeasure load. Elevated heart rate and muscle sympathetic nerve activity after bedrest were counteracted, and exaggerated response to head-up tilt was also suppressed. Centrifuge-induced artificial gravity with exercise is effective in preventing cardiovascular deconditioning due to microgravity exposure, however, an effective and appropriate regimen (magnitude of G-load and exercise workload) should be determined in future studies. c2005 Elsevier Ltd. All rights reserved.

Effectiveness of centrifuge-induced artificial gravity with ergometric exercise as a countermeasure during simulated microgravity exposure in humans

NASA Astrophysics Data System (ADS)

Iwase, Satoshi

2005-07-01

To test the effectiveness of centrifuge-induced artificial gravity with ergometric exercise, 12 healthy young men (20.7±1.9yr) were exposed to simulated microgravity for 14 days of -6∘ head-down bedrest. Half the subjects were randomly selected and loaded 1.2 G artificial gravity with 60 W (four out of six subjects) or 40 W (two out of six subjects) of ergometric workload on days 1,2,3,5,7,9,11,12,13,14 (CM group). The rest of the subjects served as the control. Anti-G score, defined as the G-load×running time to the endpoint, was significantly elongated by the load of the centrifuge-ergometer. Plasma volume loss was suppressed ( -5.0±2.4 vs. -16.4±1.9%), and fluid volume shift was prevented by the countermeasure load. Elevated heart rate and muscle sympathetic nerve activity after bedrest were counteracted, and exaggerated response to head-up tilt was also suppressed. Centrifuge-induced artificial gravity with exercise is effective in preventing cardiovascular deconditioning due to microgravity exposure, however, an effective and appropriate regimen (magnitude of G-load and exercise workload) should be determined in future studies.

Modeling Unsteady Cavitation and Dynamic Loads in Turbopumps

NASA Technical Reports Server (NTRS)

Hosangadi, Ashvin; Ahuja, Vineet; Ungewitter, Ronald; Dash, Sanford M.

2009-01-01

A computational fluid dynamics (CFD) model that includes representations of effects of unsteady cavitation and associated dynamic loads has been developed to increase the accuracy of simulations of the performances of turbopumps. Although the model was originally intended to serve as a means of analyzing preliminary designs of turbopumps that supply cryogenic propellant liquids to rocket engines, the model could also be applied to turbopumping of other liquids: this can be considered to have been already demonstrated, in that the validation of the model was performed by comparing results of simulations performed by use of the model with results of sub-scale experiments in water. The need for this or a similar model arises as follows: Cavitation instabilities in a turbopump are generated as inlet pressure drops and vapor cavities grow on inducer blades, eventually becoming unsteady. The unsteady vapor cavities lead to rotation cavitation, in which the cavities detach from the blades and become part of a fluid mass that rotates relative to the inducer, thereby generating a fluctuating load. Other instabilities (e.g., surge instabilities) can couple with cavitation instabilities, thereby compounding the deleterious effects of unsteadiness on other components of the fluid-handling system of which the turbopump is a part and thereby, further, adversely affecting the mechanical integrity and safety of the system. Therefore, an ability to predict cavitation- instability-induced dynamic pressure loads on the blades, the shaft, and other pump parts would be valuable in helping to quantify safe margins of inducer operation and in contributing to understanding of design compromises. Prior CFD models do not afford this ability. Heretofore, the primary parameter used in quantifying cavitation performance of a turbopump inducer has been the critical suction specific speed at which head breakdown occurs. This parameter is a mean quantity calculated on the basis of assumed steady-state operation of the inducer; it does not account for dynamic pressure loads associated with unsteady flow caused by instabilities. Because cavitation instabilities occur well before mean breakdown in inducers, engineers have, until now, found it necessary to use conservative factors of safety when analyzing the results of numerical simulations of flows in turbopumps.

Study on Human-structure Dynamic Interaction in Civil Engineering

NASA Astrophysics Data System (ADS)

Gao, Feng; Cao, Li Lin; Li, Xing Hua

2018-06-01

The research of human-structure dynamic interaction are reviewed. Firstly, the influence of the crowd load on structural dynamic characteristics is introduced and the advantages and disadvantages of different crowd load models are analyzed. Then, discussing the influence of structural vibration on the human-induced load, especially the influence of different stiffness structures on the crowd load. Finally, questions about human-structure interaction that require further study are presented.

Vertical Load Induced with Twisted File Adaptive System during Canal Shaping.

PubMed

Jamleh, Ahmed; Alfouzan, Khalid

2016-12-01

To evaluate the vertical load induced with the Twisted File Adaptive (TFA; SybronEndo, Orange, CA) system during canal shaping of extracted teeth by comparing it with the Twisted File (TF, SybronEndo), ProTaper Next (PTN; Dentsply Maillefer, Ballaigues, Switzerland), and ProTaper Universal (PTU, Dentsply Maillefer) systems. Fifty-two root canals were shaped using the TFA, TF, PTN, or PTU systems (n = 13 for each system). They were shaped gently according to the manufacturers' instructions. During canal shaping, vertical loads were recorded and shown in 2 directions, apically and coronally directed loads. The vertical peak loads of 3 instrumentation stages were used for comparison. The effects of rotary systems on the mean positive and negative peak loads were analyzed statistically using the Kruskal-Wallis and Mann-Whitney tests at a confidence level of 95%. The overall pattern of the instantaneous loads appeared to increase with the use of successive instruments within the system. During canal shaping in all groups, the apically and coronally directed peak loads ranged from 0.84-7.55 N and 2.16-2.79 N, respectively. There were significant differences in both peak loads among the tested systems at each instrumentation stage. TFA had the lowest apically directed peak loads. In terms of coronally directed peak loads, the TFA and TF had a significantly lower amount of loads developed with their instruments than PTN and PTU. The choice of instrument system had an influence on the loads developed during canal shaping. TFA instruments were associated favorably with the lowest values of peak loads followed by TF, PTN, and PTU. Copyright © 2016 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

A torque, tension and stress corrosion evaluation of high strength A286 bolts

NASA Technical Reports Server (NTRS)

Montano, J. W.

1986-01-01

The problems associated with overtorque applied to the Booster Separation Motor (BSM) Igniter Adapter high strength 200 KSI (1379 Mpa) A286 CRES bolts and the threaded holes of the 7075-T73 aluminum alloy BSM cases are addressed. The evaluation included torque, tensile, and stress corrosion tests incorporating the A286 CRES bolts and the 7075-T73 aluminum alloy BSM cases. The tensile test data includes ultimate tensile load (UTL), Johnson's 2/3 yield load (J2/3YL), proportional limit load (PLL), and total bolt stretch. Torque tension data includes torque, torque induced load, and positive and negative break-away torque. Stress corrosion test data reflect the overtorque and the resulting torque induced loads sustained by the A286 CRES bolts torqued into a 7075-T73 aluminum alloy forged dome with threaded holes. After 60 days of salt fog exposure, the positive and the negative break-away torques, the subsequent mechanical property tensile test results, and the BSM dome threaded hole axial tensile pullout loads are reported.

On the origin of residual strain in shape memory alloys: experimental investigation on evolutions in the microstructure of CuAlBe during complex thermomechanical loadings

NASA Astrophysics Data System (ADS)

Barati, M.; Arbab Chirani, S.; Kadkhodaei, M.; Saint-Sulpice, L.; Calloch, S.

2017-02-01

The behaviors of shape memory alloys (SMAs) strongly depend on the presence of different phases: austenite, thermally-induced martensite and stress-induced martensite. Consequently, it is important to know the phase volume fraction of each phases and their evolution during thermomechanical loadings. In this work, a three-phase proportioning method based on electric resistivity variation of a CuAlBe SMA is proposed. Simple thermomechanical loadings (i. e. pseudoplasticity and pseudoelasticity), one-way shape memory effect, recovery stress, assisted two-way memory effect at different level of stress and cyclic pseudoelasticity tests are investigated. Based on the electric resistivity results, during each loading path, evolution of the microstructure is determined. The origin of residual strain observed during the considered thermomechanical loadings is discussed. A special attention is paid to two-way shape memory effect generated after considered cyclic loadings and its relation with the developed residual strain. These results permit to identify and to validate the macroscopic models of SMAs behaviors.

Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis

PubMed Central

Li, Xinle; Yang, Jing; Liu, Daquan; Li, Jie; Niu, Kaijun; Feng, Shiqing; Yokota, Hiroki; Zhang, Ping

2016-01-01

Osteoarthritis (OA) is a whole joint disorder that involves cartilage degradation and periarticular bone response. Changes of cartilage and subchondral bone are associated with development and activity of osteoclasts from subchondral bone. Knee loading promotes bone formation, but its effects on OA have not been well investigated. Here, we hypothesized that knee loading regulates subchondral bone remodeling by suppressing osteoclast development, and prevents degradation of cartilage through crosstalk of bone-cartilage in osteoarthritic mice. Surgery-induced mouse model of OA was used. Two weeks application of daily dynamic knee loading significantly reduced OARSI scores and CC/TAC (calcified cartilage to total articular cartilage), but increased SBP (subchondral bone plate) and B.Ar/T.Ar (trabecular bone area to total tissue area). Bone resorption of osteoclasts from subchondral bone and the differentiation of osteoclasts from bone marrow-derived cells were completely suppressed by knee loading. The osteoclast activity was positively correlated with OARSI scores and negatively correlated with SBP and B.Ar/T.Ar. Furthermore, knee loading exerted protective effects by suppressing osteoclastogenesis through Wnt signaling. Overall, osteoclast lineage is the hyper responsiveness of knee loading in osteoarthritic mice. Mechanical stimulation prevents OA-induced cartilage degeneration through crosstalk with subchondral bone. Knee loading might be a new potential therapy for osteoarthritis patients. PMID:27087498

Lipid-load in peripheral blood mononuclear cells: Impact of food-consumption, dietary-macronutrients, extracellular lipid availability and demographic factors.

PubMed

Ameer, Fatima; Munir, Rimsha; Usman, Hina; Rashid, Rida; Shahjahan, Muhammad; Hasnain, Shahida; Zaidi, Nousheen

2017-04-01

Lipid-load in peripheral blood mononuclear cells (PBMCs) has recently gained attention of the researchers working on nutritional regulation of metabolic health. Previous works have indicated that the metabolic circuitries in the circulating PBMCs are influenced by dietary-intake and macronutrient composition of diet. In the present work, we analyzed the impact of diet and dietary macronutrients on PBMCs' lipid-load. The overall analyses revealed that dietary carbohydrates and fats combinatorially induce triglyceride accumulation in PBMCs. On the other hand, dietary fats were shown to induce significant decrease in PBMCs' cholesterol-load. The effects of various demographic factors -including age, gender and body-weight- on PBMCs' lipid-load were also examined. Body-weight and age were both shown to affect PBMC's lipid-load. Our study fails to provide any direct association between extracellular lipid availability and cholesterol-load in both, freshly isolated and cultured PBMCs. The presented work significantly contributes to the current understanding of the impact of food-consumption, dietary macronutrients, extracellular lipid availability and demographic factors on lipid-load in PBMCs. Copyright © 2017 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

Load cell verification of the uprated high pressure oxygen turbopump for the Space Shuttle Main Engine

NASA Technical Reports Server (NTRS)

Beatty, R. F.; Hine, M. J.

1986-01-01

The high pressure turbomachinery of the Space Shuttle Main Engine has the highest power-to-weight ratio of any operational machine known. Subsynchronous rotor whirl of the high pressure oxygen turbopump occurred in development testing at full-power level (109 percent thrust). The means by which the turbopump was successfully uprated is presented herein. The subsynchronous motion was determined to be driven by impeller destabilizing forces in combination with low net damping and bearing degradation. The degradation resulted from ball wear due primarily to an excessive loading condition of operating too near the lightly damped rotor second critical speed while under a large static load and, secondarily, from reverse bearing loading or loss of internal clearance and coolant during simulated flight conditions. The rotor response was reduced by stiffening the shaft and supports, optimizing the stiffness and damping of annular seals, and increasing the bearing deadband. The uprated oxygen turbopump configuration was verified by converting the pump and bearing support into a load cell for the purpose of systematically quantifying the load reduction benefits relative to baseline turbopumps. The damped second critical speed margin and the load sharing have been substantially improved which has resulted in reduced bearing loads for improved service life of the machine at full-power level.

Creep of plain weave polymer matrix composites

NASA Astrophysics Data System (ADS)

Gupta, Abhishek

Polymer matrix composites are increasingly used in various industrial sectors to reduce structural weight and improve performance. Woven (also known as textile) composites are one class of polymer matrix composites with increasing market share mostly due to their lightweight, their flexibility to form into desired shape, their mechanical properties and toughness. Due to the viscoelasticity of the polymer matrix, time-dependent degradation in modulus (creep) and strength (creep rupture) are two of the major mechanical properties required by engineers to design a structure reliably when using these materials. Unfortunately, creep and creep rupture of woven composites have received little attention by the research community and thus, there is a dire need to generate additional knowledge and prediction models, given the increasing market share of woven composites in load bearing structural applications. Currently, available creep models are limited in scope and have not been validated for any loading orientation and time period beyond the experimental time window. In this thesis, an analytical creep model, namely the Modified Equivalent Laminate Model (MELM), was developed to predict tensile creep of plain weave composites for any orientation of the load with respect to the orientation of the fill and warp fibers, using creep of unidirectional composites. The ability of the model to predict creep for any orientation of the load is a "first" in this area. The model was validated using an extensive experimental involving the tensile creep of plain weave composites under varying loading orientation and service conditions. Plain weave epoxy (F263)/ carbon fiber (T300) composite, currently used in aerospace applications, was procured as fabrics from Hexcel Corporation. Creep tests were conducted under two loading conditions: on-axis loading (0°) and off-axis loading (45°). Constant load creep, in the temperature range of 80-240°C and stress range of 1-70% UTS of the composites, was experimentally evaluated for time periods ranging from 1--120 hours under both loading conditions. The composite showed increase in creep with increase in temperature and stress. Creep of composite increased with increase in angle of loading, from 1% under on-axis loading to 31% under off-axis loading, within the tested time window. The experimental creep data for plain weave composites were superposed using TTSP (Time Temperature Superposition Principle) to obtain a master curve of experimental data extending to several years and was compared with model predictions to validate the model. The experimental and model results were found in good agreement within an error range of +/-1-3% under both loading conditions. A parametric study was also conducted to understand the effect of microstructure of plain weave composites on its on-axis and off-axis creep. Generation of knowledge in this area is also "first". Additionally, this thesis generated knowledge on time-dependent damage m woven composites and its effect on creep and tensile properties and their prediction.

Influences of load characteristics on impaired control of grip forces in patients with cerebellar damage.

PubMed

Brandauer, B; Timmann, D; Häusler, A; Hermsdörfer, J

2010-02-01

Various studies showed a clear impairment of cerebellar patients to modulate grip force in anticipation of the loads resulting from movements with a grasped object. This failure corroborated the theory of internal feedforward models in the cerebellum. Cerebellar damage also impairs the coordination of multiple-joint movements and this has been related to deficient prediction and compensation of movement-induced torques. To study the effects of disturbed torque control on feedforward grip-force control, two self-generated load conditions with different demands on torque control-one with movement-induced and the other with isometrically generated load changes-were directly compared in patients with cerebellar degeneration. Furthermore the cerebellum is thought to be more involved in grip-force adjustment to self-generated loads than to externally generated loads. Consequently, an additional condition with externally generated loads was introduced to further test this hypothesis. Analysis of 23 patients with degenerative cerebellar damage revealed clear impairments in predictive feedforward mechanisms in the control of both self-generated load types. Besides feedforward control, the cerebellar damage also affected more reactive responses when the externally generated load destabilized the grip, although this impairment may vary with the type of load as suggested by control experiments. The present findings provide further support that the cerebellum plays a major role in predictive control mechanisms. However, this impact of the cerebellum does not strongly depend on the nature of the load and the specific internal forward model. Contributions to reactive (grip force) control are not negligible, but seem to be dependent on the physical characteristics of an externally generated load.

A distributed computing approach to mission operations support. [for spacecraft

NASA Technical Reports Server (NTRS)

Larsen, R. L.

1975-01-01

Computing mission operation support includes orbit determination, attitude processing, maneuver computation, resource scheduling, etc. The large-scale third-generation distributed computer network discussed is capable of fulfilling these dynamic requirements. It is shown that distribution of resources and control leads to increased reliability, and exhibits potential for incremental growth. Through functional specialization, a distributed system may be tuned to very specific operational requirements. Fundamental to the approach is the notion of process-to-process communication, which is effected through a high-bandwidth communications network. Both resource-sharing and load-sharing may be realized in the system.

The pricing effect of the common pattern in firm-level idiosyncratic volatility: Evidence from A-Share stocks of China

NASA Astrophysics Data System (ADS)

Su, Zhi; Shu, Tengjia; Yin, Libo

2018-05-01

Inspired by Herskovic et al. (2016), we investigate the pricing effect of the firm-level common idiosyncratic volatility (CIV) in China's A-Share market. Return tests indicate that lower CIV risk loadings bring higher returns significantly, while the pricing function of market volatility (MV) is inconsistent. Strategy that goes long the highest CIV-beta quintile and short the lowest CIV-beta quintile brings an annualized average return of 5%-7%. Our findings supplement Herskovic et al. (2016) by confirming a significantly negative relationship between CIV and stock returns in a developing market.

Efficacy of an automated ultraviolet C device in a shared hospital bathroom.

PubMed

Cooper, Jesse; Bryce, Elizabeth; Astrakianakis, George; Stefanovic, Aleksandra; Bartlett, Karen

2016-12-01

Toilet flushing can contribute to disease transmission by generating aerosolized bacteria and viruses that can land on nearby surfaces or follow air currents. Aerobic and anaerobic bacterial bioaerosol loads, and bacterial counts on 2 surfaces in a bathroom with a permanently installed, automated ultraviolet C (UVC) irradiation device, were significantly lower than in a comparable bathroom without the UVC device. Permanently installed UVC lights may be a useful supplementary decontamination tool in shared patient bathrooms. Copyright © 2016 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

Evaluation of effects of super-heavy loading on the US 41 bridge over the White River : appendices.

DOT National Transportation Integrated Search

2011-01-01

Built in 1958, the US-41 White River Bridge is a two-girder, riveted steel structure located in Hazelton, IN. The bridge is comprised of two, sixteen span superstructures sharing a common substructure. Each superstructure also contains four pin and h...

Evaluation of effects of super-heavy loading on the US 41 bridge over the White River.

DOT National Transportation Integrated Search

2011-01-01

Built in 1958, the US-41 White River Bridge is a two-girder, riveted steel structure located in Hazelton, IN. The bridge is comprised of two, sixteen span : superstructures sharing a common substructure. Each superstructure also contains four pin and...

Sharing the Load Denver Public Schools' Differentiated Roles Pilot

ERIC Educational Resources Information Center

Aspen Institute, 2014

2014-01-01

To assist system administrators as they pursue their own teacher leadership initiatives, this profile from Leading Educators and the Aspen Institute details the steps Denver Public Schools (DPS) took to design and implement its Differentiated Roles pilot. Specifically, it examines the initiative's opportunities and challenges within the context of…

14 CFR 1214.813 - Computation of sharing and pricing parameters.

Code of Federal Regulations, 2012 CFR

2012-01-01

... paragraph of this section shall be applied as indicated. The procedure for computing Shuttle load factor, charge factor, and flight price for Spacelab payloads replaces the procedure contained in the Shuttle policy. (2) Shuttle charge factors as derived herein apply to the standard mission destination of 160 nmi...

14 CFR 1214.813 - Computation of sharing and pricing parameters.

Code of Federal Regulations, 2013 CFR

2013-01-01

... paragraph of this section shall be applied as indicated. The procedure for computing Shuttle load factor, charge factor, and flight price for Spacelab payloads replaces the procedure contained in the Shuttle policy. (2) Shuttle charge factors as derived herein apply to the standard mission destination of 160 nmi...

14 CFR § 1214.813 - Computation of sharing and pricing parameters.

Code of Federal Regulations, 2014 CFR

2014-01-01

... paragraph of this section shall be applied as indicated. The procedure for computing Shuttle load factor, charge factor, and flight price for Spacelab payloads replaces the procedure contained in the Shuttle policy. (2) Shuttle charge factors as derived herein apply to the standard mission destination of 160 nmi...

14 CFR 1214.813 - Computation of sharing and pricing parameters.

Code of Federal Regulations, 2011 CFR

2011-01-01

... paragraph of this section shall be applied as indicated. The procedure for computing Shuttle load factor, charge factor, and flight price for Spacelab payloads replaces the procedure contained in the Shuttle policy. (2) Shuttle charge factors as derived herein apply to the standard mission destination of 160 nmi...

Sharing the Literacy Load

ERIC Educational Resources Information Center

Orechovsky, Patricia

2010-01-01

The literacy team at Brentwood (NY) High School, a large urban high school, focused its efforts on building content-area teachers' literacy instruction skills. The team is made up of teachers from the various content areas, including physical education and art, as well as supportive administrators. The team developed a pacing guide, a monthly…

Financial Planning Strategies for Senior Military Officers.

DTIC Science & Technology

1986-05-15

being offered has declined significantly. In that preferred shares are a sort of hybrid of common stocks and bonds. they offer a middle of the road...2. Total return no-load mutual funds should be your first consideraticn in selectirg an investment veiclE . Avoid speculative, non-liquid investments

Evaluation of effects of super-heavy loading on the US 41 bridge over the White River : technical summary.

DOT National Transportation Integrated Search

2011-01-01

Built in 1958, the US-41 White River Bridge is a two-girder, riveted steel structure located near Hazelton, IN. The bridge is comprised of two, sixteen span superstructures sharing a common substructure. Each superstructure also contains four pin and...

Exercise-Induced Bronchoconstriction (EIB)

MedlinePlus

... Primary Immunodeficiency Disease Related Conditions Drug Guide Conditions Dictionary Just for Kids Library School Tools Videos Virtual ... Search AAAAI Breadcrumb navigation Home ▸ Conditions & Treatments ▸ Conditions Dictionary ▸ ... Share | Exercise-Induced Bronchoconstriction (EIB) « ...

A review of research in rotor loads

NASA Technical Reports Server (NTRS)

Bousman, William G.; Mantay, Wayne R.

1988-01-01

The research accomplished in the area of rotor loads over the last 13 to 14 years is reviewed. The start of the period examined is defined by the 1973 AGARD Milan conference and the 1974 hypothetical rotor comparison. The major emphasis of the review is research performed by the U.S. Army and NASA at their laboratories and/or by the industry under government contract. For the purpose of this review, two main topics are addressed: rotor loads prediction and means of rotor loads reduction. A limited discussion of research in gust loads and maneuver loads is included. In the area of rotor loads predictions, the major problem areas are reviewed including dynamic stall, wake induced flows, blade tip effects, fuselage induced effects, blade structural modeling, hub impedance, and solution methods. It is concluded that the capability to predict rotor loads has not significantly improved in this time frame. Future progress will require more extensive correlation of measurements and predictions to better understand the causes of the problems, and a recognition that differences between theory and measurement have multiple sources, yet must be treated as a whole. There is a need for high-quality data to support future research in rotor loads, but the resulting data base must not be seen as an end in itself. It will be useful only if it is integrated into firm long-range plans for the use of the data.

In vitro and in vivo Effects of Free and Chalcones-Loaded Nanoemulsions: Insights and Challenges in Targeted Cancer Chemotherapies

PubMed Central

Winter, Evelyn; Dal Pizzol, Carine; Locatelli, Claudriana; Silva, Adny H.; Conte, Aline; Chiaradia-Delatorre, Louise D.; Nunes, Ricardo J.; Yunes, Rosendo A.; Creckzynski-Pasa, Tânia B.

2014-01-01

Several obstacles are encountered in conventional chemotherapy, such as drug toxicity and poor stability. Nanotechnology is envisioned as a strategy to overcome these effects and to improve anticancer therapy. Nanoemulsions comprise submicron emulsions composed of biocompatible lipids, and present a large surface area revealing interesting physical properties. Chalcones are flavonoid precursors, and have been studied as cytotoxic drugs for leukemia cells that induce cell death by different apoptosis pathways. In this study, we encapsulated chalcones in a nanoemulsion and compared their effect with the respective free compounds in leukemia and in non-tumoral cell lines, as well as in an in vivo model. Free and loaded-nanoemulsion chalcones induced a similar anti-leukemic effect. Free chalcones induced higher toxicity in VERO cells than chalcones-loaded nanoemulsions. Similar results were observed in vivo. Free chalcones induced a reduction in weight gain and liver injuries, evidenced by oxidative stress, as well as an inflammatory response. Considering the high toxicity and the side effects induced generally by all cancer chemotherapies, nanotechnology provides some options for improving patients’ life quality and/or increasing survival rates. PMID:25264679

A nanometallic nickel-coated, glass-fibre-based structural health monitoring system for polymer composites

NASA Astrophysics Data System (ADS)

Balaji, R.; Sasikumar, M.

2017-09-01

Glass-fibre-reinforced polymer matrix composites are widely used in various industries because of their unique high strength to weight ratio. Unlike metals, strain-induced and damage states of composites are complicated to predict under real-time loading due to their anisotropic nature. With that focus, a piezoresistive nanomaterial-based structural health monitoring system for laminated polymer composites is proposed to measure the strain induced in the composite under real-time loading. Nanometallic nickel-coated glass fibres are embedded into the polymer composites to monitor the strain and damage induced in them. The nanometallic nickel is coated over the glass fibre by a dip coating technique using epoxy as the binding agent. A microcontroller-based electrical resistance measurement system is used to measure the piezoresistive variation in the coated glass fibre under real-time loading. Using the piezoresistance variation of the embedded nanometallic nickel-coated glass fibre, the real-time strain and damage induced in the composite can be correlated. The piezoresistive response of the coated glass fibre is descibed in two phases, the deformation phase and the failure phase, which clearly show the various states of strain and damage induced in the composites.

Trajectory Prediction of Spin-Stabilized Projectiles With a Steady Liquid Payload

DTIC Science & Technology

2011-11-01

analysis assumes the effect of a liquid payload is similar to the Magnus effect . Spectral analysis used to numerically compute liquid-fill induced...the internal motion of a liquid payload can induce destabilizing moments on the projectile. This report creates a method to include the effect of... effect , liquid payload moments are added to the applied loads on the projectile. These loads are computed by solving the linearized Navier-Stokes

Nonplanar wing load-line and slender wing theory

NASA Technical Reports Server (NTRS)

Deyoung, J.

1977-01-01

Nonplanar load line, slender wing, elliptic wing, and infinite aspect ratio limit loading theories are developed. These are quasi two dimensional theories but satisfy wing boundary conditions at all points along the nonplanar spanwise extent of the wing. These methods are applicable for generalized configurations such as the laterally nonplanar wing, multiple nonplanar wings, or wing with multiple winglets of arbitrary shape. Two dimensional theory infers simplicity which is practical when analyzing complicated configurations. The lateral spanwise distribution of angle of attack can be that due to winglet or control surface deflection, wing twist, or induced angles due to multiwings, multiwinglets, ground, walls, jet or fuselage. In quasi two dimensional theory the induced angles due to these extra conditions are likewise determined for two dimensional flow. Equations are developed for the normal to surface induced velocity due to a nonplanar trailing vorticity distribution. Application examples are made using these methods.

Inducer Hydrodynamic Forces in a Cavitating Environment

NASA Technical Reports Server (NTRS)

Skelley, Stephen E.

2004-01-01

Marshall Space Flight Center has developed and demonstrated a measurement device for sensing and resolving the hydrodynamic loads on fluid machinery. The device - a derivative of the six-component wind tunnel balance - senses the forces and moments on the rotating device through a weakened shaft section instrumented with a series of strain gauges. This rotating balance was designed to directly measure the steady and unsteady hydrodynamic loads on an inducer, thereby defining the amplitude and frequency content associated with operating in various cavitation modes. The rotating balance was calibrated statically using a dead-weight load system in order to generate the 6 x 12 calibration matrix later used to convert measured voltages to engineering units. Structural modeling suggested that the rotating assembly first bending mode would be significantly reduced with the balance s inclusion. This reduction in structural stiffness was later confirmed experimentally with a hammer-impact test. This effect, coupled with the relatively large damping associated with the rotating balance waterproofing material, limited the device s bandwidth to approximately 50 Hertz Other pre-test validations included sensing the test article rotating assembly built-in imbalance for two configurations and directly measuring the assembly mass and buoyancy while submerged under water. Both tests matched predictions and confirmed the device s sensitivity while stationary and rotating. The rotating balance was then demonstrated in a water test of a full-scale Space Shuttle Main Engine high-pressure liquid oxygen pump inducer. Experimental data was collected a scaled operating conditions at three flow coefficients across a range of cavitation numbers for the single inducer geometry and radial clearance. Two distinct cavitation modes were observed symmetric tip vortex cavitation and alternate-blade cavitation. Although previous experimental tests on the same inducer demonstrated two additional cavitation modes at lower inlet pressures, these conditions proved unreachable with the rotating balance installed due to the intense dynamic environment. The sensed radial load was less influenced by flow coefficient than by cavitation number or cavitation mode although the flow coefficient range was relatively narrow. Transition from symmetric tip vortex to alternate-blade cavitation corresponded to changes in both radial load magnitude and radial load orientation relative to the inducer. Sensed moments indicated that the effective load center moved downstream during this change in cavitation mode. An occurrence of "higher+rdex cavitation" was also detected in both the stationary pressures and the rotating balance data although the frequency of the phenomena was well above the reliable bandwidth of the rotating balance. In summary the experimental tests proved both the concept and device s capability despite the limitations and confirmed that hydrodynamically-induced forces and moments develop in response to the unbalanced pressure field, which is, in turn, a product of the cavitation environment.

Protective effect of magnolol-loaded polyketal microparticles on lipopolysaccharide-induced acute lung injury in rats.

PubMed

Tsai, Tsuimin; Kao, Chen-Yu; Chou, Chun-Liang; Liu, Lu-Chun; Chou, Tz-Chong

2016-08-01

Magnolol has shown inhibitory effects on NO production and TNF-alpha production in lipopolysaccharide (LPS)-activated macrophages and LPS-induced acute lung injury; however, the poor solubility of magnolol has hindered its clinical success. In this study, magnolol-loaded microparticles were prepared via single emulsion method from a polyketal polymer, termed PK3. The particle sizes of magnolol-loaded PK3 microparticle is 3.73 ± 0.41 μm, and was suitable for phagocytosis by macrophages and pulmonary drug delivery. PK3 microparticles exhibited excellent biocompatibility both in vitro and in vivo. More importantly, intratracheal delivery of these magnolol-loaded microparticles significantly reduced the lung inflammatory responses at low dosage of magnolol (0.5 mg/kg), and have great clinical potential in treating acute lung injury.

Mechanical behaviour of TWIP steel under shear loading

NASA Astrophysics Data System (ADS)

Vincze, G.; Butuc, M. C.; Barlat, F.

2016-08-01

Twinning induced plasticity steels (TWIP) are very good candidate for automotive industry applications because they potentially offer large energy absorption before failure due to their exceptional strain hardening capability and high strength. However, their behaviour is drastically influenced by the loading conditions. In this work, the mechanical behaviour of a TWIP steel sheet sample was investigated at room temperature under monotonic and reverse simple shear loading. It was shown that all the expected features of load reversal such as Bauschinger effect, transient strain hardening with high rate and permanent softening, depend on the prestrain level. This is in agreement with the fact that these effects, which occur during reloading, are related to the rearrangement of the dislocation structure induced during the predeformation. The homogeneous anisotropic hardening (HAH) approach proposed by Barlat et al. (2011) [1] was successfully employed to predict the experimental results.

Transient Three-Dimensional Side Load Analysis of Out-of-Round Film Cooled Nozzles

NASA Technical Reports Server (NTRS)

Wang, Ten-See; Lin, Jeff; Ruf, Joe; Guidos, Mike

2010-01-01

The objective of this study is to investigate the effect of nozzle out-of-roundness on the transient startup side loads. The out-of-roundness could be the result of asymmetric loads induced by hardware attached to the nozzle, asymmetric internal stresses induced by previous tests and/or deformation, such as creep, from previous tests. The rocket engine studied encompasses a regeneratively cooled thrust chamber and a film cooled nozzle extension with film coolant distributed from a turbine exhaust manifold. The computational methodology is based on an unstructured-grid, pressure-based computational fluid dynamics formulation, and a transient inlet history based on an engine system simulation. Transient startup computations were performed with the out-of-roundness achieved by four degrees of ovalization of the nozzle: one perfectly round, one slightly out-of-round, one more out-of-round, and one significantly out-of-round. The computed side load physics caused by the nozzle out-of-roundness and its effect on nozzle side load are reported and discussed.

The analysis of dynamic characteristics and wind-induced displacement response of space Beam String Structure

NASA Astrophysics Data System (ADS)

Chen, Yong Jian; Feng, Zhen Fa; Qi, Ai; Huang, Ying

2018-06-01

The Beam String Structure structural system, also called BSS, has the advantages of lighter dead weight and greater flexibility. The wind load is the main design control factor. The dynamic characteristics and wind-induced displacement response of BSS are studied by the finite element method. The roof structure of the stadium roof of the Fuzhou Olympic Sports Center is the engineering background. 1)The numerical model was built by ANSYS, by shape finding, determine the initial stress state of structural members such as external cables; 2)From the analysis of dynamic characteristics, the main mode of vibration is the vibration of cables; 3)The wind speed spectrum of MATLAB generation structure is obtained by AR method, the structural response of the structure under static wind load and fluctuating wind load is calculated. From the analysis result, considering the equivalent static wind load of BSS , the design of adverse wind is not safe, and the fluctuating wind load should be taken into account.

Crack growth induced by thermal-mechanical loading

NASA Astrophysics Data System (ADS)

John, R.; Hartman, G. A.; Gallagher, J. P.

1992-06-01

Advanced aerospace structures are often subjected to combined thermal and mechanical loads. The fracture-mechanics behavior of the structures may be altered by the thermal state existing around the crack. Hence, design of critical structural elements requires the knowledge of stress-intensity factors under both thermal and mechanical loads. This paper describes the development of an experimental technique to verify the thermal-stress-intensity factor generated by a temperature gradient around the crack. Thin plate specimens of a model material (AISI-SAE 1095 steel) were used for the heat transfer and thermal-mechanical fracture tests. Rapid thermal loading was achieved using high-intensity focused infrared spot heaters. These heaters were also used to generate controlled temperature rates for heat-transfer verification tests. The experimental results indicate that thermal loads can generate stress-intensity factors large enough to induce crack growth. The proposed thermal-stress-intensity factors appear to have the same effect as the conventional mechanical-stress-intensity factors with respect to fracture.

Human climbing with efficiently scaled gecko-inspired dry adhesives.

PubMed

Hawkes, Elliot W; Eason, Eric V; Christensen, David L; Cutkosky, Mark R

2015-01-06

Since the discovery of the mechanism of adhesion in geckos, many synthetic dry adhesives have been developed with desirable gecko-like properties such as reusability, directionality, self-cleaning ability, rough surface adhesion and high adhesive stress. However, fully exploiting these adhesives in practical applications at different length scales requires efficient scaling (i.e. with little loss in adhesion as area grows). Just as natural gecko adhesives have been used as a benchmark for synthetic materials, so can gecko adhesion systems provide a baseline for scaling efficiency. In the tokay gecko (Gekko gecko), a scaling power law has been reported relating the maximum shear stress σmax to the area A: σmax ∝ A(-1/4). We present a mechanical concept which improves upon the gecko's non-uniform load-sharing and results in a nearly even load distribution over multiple patches of gecko-inspired adhesive. We created a synthetic adhesion system incorporating this concept which shows efficient scaling across four orders of magnitude of area, yielding an improved scaling power law: σmax ∝ A(-1/50). Furthermore, we found that the synthetic adhesion system does not fail catastrophically when a simulated failure is induced on a portion of the adhesive. In a practical demonstration, the synthetic adhesion system enabled a 70 kg human to climb vertical glass with 140 cm(2) of adhesive per hand. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

Fruit load induces changes in global gene expression and in abscisic acid (ABA) and indole acetic acid (IAA) homeostasis in citrus buds

PubMed Central

Shalom, Liron; Samuels, Sivan; Zur, Naftali; Shlizerman, Lyudmila; Doron-Faigenboim, Adi; Blumwald, Eduardo; Sadka, Avi

2014-01-01

Many fruit trees undergo cycles of heavy fruit load (ON-Crop) in one year, followed by low fruit load (OFF-Crop) the following year, a phenomenon known as alternate bearing (AB). The mechanism by which fruit load affects flowering induction during the following year (return bloom) is still unclear. Although not proven, it is commonly accepted that the fruit or an organ which senses fruit presence generates an inhibitory signal that moves into the bud and inhibits apical meristem transition. Indeed, fruit removal from ON-Crop trees (de-fruiting) induces return bloom. Identification of regulatory or metabolic processes modified in the bud in association with altered fruit load might shed light on the nature of the AB signalling process. The bud transcriptome of de-fruited citrus trees was compared with those of ON- and OFF-Crop trees. Fruit removal resulted in relatively rapid changes in global gene expression, including induction of photosynthetic genes and proteins. Altered regulatory mechanisms included abscisic acid (ABA) metabolism and auxin polar transport. Genes of ABA biosynthesis were induced; however, hormone analyses showed that the ABA level was reduced in OFF-Crop buds and in buds shortly following fruit removal. Additionally, genes associated with Ca2+-dependent auxin polar transport were remarkably induced in buds of OFF-Crop and de-fruited trees. Hormone analyses showed that auxin levels were reduced in these buds as compared with ON-Crop buds. In view of the auxin transport autoinhibition theory, the possibility that auxin distribution plays a role in determining bud fate is discussed. PMID:24706719

Sost, independent of the non-coding enhancer ECR5, is required for bone mechanoadaptation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robling, Alexander G.; Kang, Kyung Shin; Bullock, Whitney A.

Here, sclerostin ( Sost) is a negative regulator of bone formation that acts upon the Wnt signaling pathway. Sost is mechanically regulated at both mRNA and protein level such that loading represses and unloading enhances Sost expression, in osteocytes and in circulation. The non-coding evolutionarily conserved enhancer ECR5 has been previously reported as a transcriptional regulatory element required for modulating Sost expression in osteocytes. Here we explored the mechanisms by which ECR5, or several other putative transcriptional enhancers regulate Sost expression, in response to mechanical stimulation. We found that in vivo ulna loading is equally osteoanabolic in wildtype and Sostmore » –/– mice, although Sost is required for proper distribution of load-induced bone formation to regions of high strain. Using Luciferase reporters carrying the ECR5 non-coding enhancer and heterologous or homologous h SOST promoters, we found that ECR5 is mechanosensitive in vitro and that ECR5-driven Luciferase activity decreases in osteoblasts exposed to oscillatory fluid flow. Yet, ECR5–/– mice showed similar magnitude of load-induced bone formation and similar periosteal distribution of bone formation to high-strain regions compared to wildtype mice. Further, we found that in contrast to Sost–/– mice, which are resistant to disuse-induced bone loss, ECR5–/– mice lose bone upon unloading to a degree similar to wildtype control mice. ECR5 deletion did not abrogate positive effects of unloading on Sost, suggesting that additional transcriptional regulators and regulatory elements contribute to load-induced regulation of Sost.« less

Sost, independent of the non-coding enhancer ECR5, is required for bone mechanoadaptation

DOE PAGES

Robling, Alexander G.; Kang, Kyung Shin; Bullock, Whitney A.; ...

2016-09-04

Here, sclerostin ( Sost) is a negative regulator of bone formation that acts upon the Wnt signaling pathway. Sost is mechanically regulated at both mRNA and protein level such that loading represses and unloading enhances Sost expression, in osteocytes and in circulation. The non-coding evolutionarily conserved enhancer ECR5 has been previously reported as a transcriptional regulatory element required for modulating Sost expression in osteocytes. Here we explored the mechanisms by which ECR5, or several other putative transcriptional enhancers regulate Sost expression, in response to mechanical stimulation. We found that in vivo ulna loading is equally osteoanabolic in wildtype and Sostmore » –/– mice, although Sost is required for proper distribution of load-induced bone formation to regions of high strain. Using Luciferase reporters carrying the ECR5 non-coding enhancer and heterologous or homologous h SOST promoters, we found that ECR5 is mechanosensitive in vitro and that ECR5-driven Luciferase activity decreases in osteoblasts exposed to oscillatory fluid flow. Yet, ECR5–/– mice showed similar magnitude of load-induced bone formation and similar periosteal distribution of bone formation to high-strain regions compared to wildtype mice. Further, we found that in contrast to Sost–/– mice, which are resistant to disuse-induced bone loss, ECR5–/– mice lose bone upon unloading to a degree similar to wildtype control mice. ECR5 deletion did not abrogate positive effects of unloading on Sost, suggesting that additional transcriptional regulators and regulatory elements contribute to load-induced regulation of Sost.« less

Comparison of original and generic clopidogrel 600 mg loading dose in the patients who planned undergoing coronary angiography.

PubMed

Srimahachota, Suphot; Rojnuckarin, Ponlapat; Udayachalerm, Wasan; Buddhari, Wacin; Chaipromprasit, Jarkarpun; Lertsuwunseri, Vorarit; Akkawat, Benjaporn; Jirapattrathamrong, Somboon

2012-12-01

To compare the efficacy and safety of original (Plavix) and generic (Apolets) clopidogrel 600 mg loading in patients planning to undergo coronary angiography. This is an experimental design, parallel, randomized-controlled study. Coronary artery disease patients planned for cardiac catheterization were recruited Patients were randomized to receive either original or generic clopidogrel 600 mg loading dose. Platelet aggregation induced by 5 micromol/L and 20 micromol/L adenosine diphosphate (ADP) was measured by light transmission aggregometry (LTA) at baseline and 6 hours after clopidogrel 600 mg administration. Forty-nine patients were enrolled, 24 patients received original clopidogrel, and 25 patients received generic clopidogrel. After six hours of loading, there was significantly reduction in platelet aggregation induced by adenosine 5 micromol/L from 41.08 +/- 3.04% to 19.50 +/- 1.68% (p < 0.001) in original group compared to 36.76 +/- 2.66% to 21.32 +/- 2.60% (p < 0.001) in generic group. When induced by 20 micromol/L, the platelet aggregation was reduced from 58.50 +/- 2.09% to 32.25 +/- 2.30% (p < 0.001) in original group and from 61.12 +/- 2.54% to 30.04 +/- 3.14% (p < 0.001) in generic group. There was no significant difference between original and generic clopidogrel in reducing platelet aggregation induced by both adenosine 5 and 20 micromol/L. Groin hematoma was found in one case (4.2%) in the original clopidogrel group. Generic clopidogrel (Apolets) 600 mg loading dose is as effective as original clopidogrel (Plavix) in term of platelet aggregation inhibition.

Effect of ginsenoside Rg3 on tyrosine hydroxylase and related mechanisms in the forced swimming-induced fatigue rats.

PubMed

Xu, Yuxia; Zhang, Peng; Wang, Chu; Shan, Ye; Wang, Dandan; Qian, Fenglei; Sun, Mengwei; Zhu, Cuiqing

2013-10-28

Ginsenoside Rg3 has shown multiple pharmacological activities and been considered as one of the most promising approaches for fatigue treatment. However, little is known about the cellular and molecular mechanisms of Rg3 on anti-fatigue and the effect of Rg3 on dopaminergic system has not been reported yet. The major aim of this study is to investigate the effect of Rg3 on TH expression and the related biochemical parameters, such as PKAα, ERK1/2, Akt and α-synuclein in brain of fatigue rats. Weight-loaded forced swimming was performed to establish an animal model of fatigue. Rg3 (10mg/kg, 50mg/kg and 100mg/kg) was intragastrically administrated before swimming. The effect of Rg3 on the expression and phosphorylation of TH and TH-related proteins in fatigue rats or in SH-SY5Y cells was assessed with western blotting. HPLC was used to examine the level of DA and DOPAC in the fatigue rats tissues. TH and phosphorylated TH were decreased in different brain regions of which ventral midbrain were less affected in weight-loaded forced swimming rats. Pretreatment with Rg3 significantly suppressed fatigue-induced decrease expression of TH and TH phosphorylation. Also treatment with Rg3 reversed the decrease expression of PKAα as well as the phosphorylation of ERK1/2 and Akt which were induced by weight-loaded forced swimming. Moreover, weight-loaded swimming could induce the increase expression of α-synuclein in hippocampus and midbrain, while suppressed α-synuclein expression in striatum and prefrontal cortex. Furthermore, Rg3 could induce the increase of TH expression and phosphorylation which was accompanied with elevated expression and phosphorylation of related kinase proteins in vitro, while the inhibitors of kinase proteins could suppress these effects of Rg3. In addition, HPLC results showed that Rg3 could reverse the weight-loaded swimming-induced increase of DOPAC/DA ratio. Our data suggest that fatigue can induce the decrease of DA which might partially result from the change of TH expression and phosphorylation, and Rg3 can reverse these fatigue-induced changes. The underling mechanisms may include the activity changes of PKAα, ERK1/2, Akt and α-synuclein. © 2013 Published by Elsevier Ireland Ltd.

Protective effect of dietary potassium against vascular injury in salt-sensitive hypertension.

PubMed

Kido, Makiko; Ando, Katsuyuki; Onozato, Maristela L; Tojo, Akihiro; Yoshikawa, Masahiro; Ogita, Teruhiko; Fujita, Toshiro

2008-02-01

Hypertensive cardiovascular damage is accelerated by salt loading but counteracted by dietary potassium supplementation. We suggested recently that antioxidant actions of potassium contribute to protection against salt-induced cardiac dysfunction. Therefore, we examined whether potassium supplementation ameliorated cuff-induced vascular injury in salt-sensitive hypertension via suppression of oxidative stress. Four-week-old Dahl salt-sensitive rats were fed a normal-salt (0.3% NaCl), high-salt (8% NaCl), or high-salt plus high-potassium (8% KCl) diet for 5 weeks, and some of the rats fed a high-salt diet were also given antioxidants. One week after the start of the treatments, a silicone cuff was implanted around the femoral artery. Examination revealed increased cuff-induced neointimal proliferation with adventitial macrophage infiltration in arteries from salt-loaded Dahl salt-sensitive rats compared with that in arteries from non-salt-loaded animals (intima/media ratio: 0.471+/-0.070 versus 0.302+/-0.037; P<0.05), associated with regional superoxide overproduction and reduced nicotinamide-adenine dinucleotide phosphate oxidase activation and mRNA overexpression. On the other hand, simultaneous potassium supplementation attenuated salt-induced neointimal hyperplasia (intima/media ratio: 0.205+/-0.012; P<0.001), adventitial macrophage infiltration, superoxide overproduction, and reduced nicotinamide-adenine dinucleotide phosphate oxidase activation and overexpression. Antioxidants, which decrease vascular oxidative stress, also reduced neointima formation induced by salt excess. In conclusion, high-potassium diets seems to have a protective effect against the development of vascular damage induced by salt loading mediated, at least in part, through suppression of the production of reactive oxygen species probably generated by reduced nicotinamide-adenine dinucleotide phosphate oxidase.

Closure of mitochondrial potassium channels favors opening of the Tl(+)-induced permeability transition pore in Ca(2+)-loaded rat liver mitochondria.

PubMed

Korotkov, Sergey M; Brailovskaya, Irina V; Shumakov, Anton R; Emelyanova, Larisa V

2015-06-01

It is known that a closure of ATP sensitive (mitoKATP) or BK-type Ca(2+) activated (mitoKCa) potassium channels triggers opening of the mitochondrial permeability transition pore (MPTP) in cells and isolated mitochondria. We found earlier that the Tl(+)-induced MPTP opening in Ca(2+)-loaded rat liver mitochondria was accompanied by a decrease of 2,4-dinitrophenol-uncoupled respiration and increase of mitochondrial swelling and ΔΨmito dissipation in the medium containing TlNO3 and KNO3. On the other hand, our study showed that the mitoKATP inhibitor, 5-hydroxydecanoate favored the Tl(+)-induced MPTP opening in the inner membrane of Ca(2+)-loaded rat heart mitochondria (Korotkov et al. 2013). Here we showed that 5-hydroxydecanoate increased the Tl(+)-induced MPTP opening in the membrane of rat liver mitochondria regardless of the presence of mitoKATP modulators (diazoxide and pinacidil). This manifested in more pronounced decrease in the uncoupled respiration and acceleration of both the swelling and the ΔΨmito dissipation in isolated rat liver mitochondria, incubated in the medium containing TlNO3, KNO3, and Ca(2+). A slight delay in Ca(2+)-induced swelling of the mitochondria exposed to diazoxide could be result of an inhibition of succinate oxidation by the mitoKATP modulator. Mitochondrial calcium retention capacity (CRC) was markedly decreased in the presence of the mitoKATP inhibitor (5-hydroxydecanoate) or the mitoKCa inhibitor (paxilline). We suggest that the closure of mitoKATP or mitoKCa in calcium loaded mitochondria favors opening of the Tl(+)-induced MPTP in the inner mitochondrial membrane.

Magnetic Random Access Memory for Embedded Computing

DTIC Science & Technology

2007-10-29

layer, w he free layer hose resistan .  ce  2. Develop and model  data  storage circuits  based  on the MTJ cells. 3. Integrated the MTJ cells into a CMOS...suggested the two methods shown in Fig. 4.5 [95]. The circuit shown at the top of the figure uses NMOS pass transistors to load data , which is the simplest... method but requires careful design to avoid charge sharing and accommodate the data -dependent loading seen at the DATA input. With additional

A study on economic power dispatch grid connected PV power plant in educational institutes

NASA Astrophysics Data System (ADS)

Singh, Kuldip; Kumar, M. Narendra; Mishra, Satyasis

2018-04-01

India has main concerns on environment and escalation of fuel prices with respect to diminution of fossil fuel reserves and the major focus on renewable Energy sources for power generation to fulfill the present and future energy demand. Installation of PV power plants in the Educational Institutions has grown up drastically throughout India. More PV power plant are integrated with load and grid through net metering. Therefore, this paper is an analysis of the 75kWp PV plant at chosen buses, considering the need of minimum demand from the grid. The case study is carried out for different generation level throughout the day and year w.r.t load and climate changes, load sharing on grid. The economic dispatch model developed for PV plant integrated with Grid.

An Improved Distributed Secondary Control Method for DC Microgrids With Enhanced Dynamic Current Sharing Performance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Panbao; Lu, Xiaonan; Yang, Xu

This paper proposes an improved distributed secondary control scheme for dc microgrids (MGs), aiming at overcoming the drawbacks of conventional droop control method. The proposed secondary control scheme can remove the dc voltage deviation and improve the current sharing accuracy by using voltage-shifting and slope-adjusting approaches simultaneously. Meanwhile, the average value of droop coefficients is calculated, and then it is controlled by an additional controller included in the distributed secondary control layer to ensure that each droop coefficient converges at a reasonable value. Hence, by adjusting the droop coefficient, each participating converter has equal output impedance, and the accurate proportionalmore » load current sharing can be achieved with different line resistances. Furthermore, the current sharing performance in steady and transient states can be enhanced by using the proposed method. The effectiveness of the proposed method is verified by detailed experimental tests based on a 3 × 1 kW prototype with three interface converters.« less

Laser Assisted CVD Growth of A1N and GaN

DTIC Science & Technology

1990-08-31

additional cost sharing. RESEARCH FACILITIES The york is being performed in the Howard University Laser Laboratory. This is a free-standing buildinq...would be used to optimize computer models of the laser induced CVD reactor. FACILITIES AND EQUIPMENT - ADDITIONAL COST SHARING This year Howard ... University has provided $45,000 for the purchase of an excimer laser to be shared by Dr. Crye for the diode laser probe experiments and another Assistant

Attraction induced frictionless sliding of rare gas monolayer on metallic surfaces: an efficient strategy for superlubricity.

PubMed

Sun, Junhui; Zhang, Yanning; Lu, Zhibin; Xue, Qunji; Wang, Liping

2017-05-10

Friction on a nanoscale revealed rich load-dependent behavior, which departs strongly from the long-standing Amonton's law. Whilst electrostatic repulsion-induced friction collapse for rare gas sliding over metallic surfaces in a high-load regime was reported by Righi et al. (Phys. Rev. Lett., 2007, 99, 176101), the significant role of attraction on frictional properties has not been reported to date. In this study, the frictional motion of Xe/Cu(111), Xe/Pd(111) and Ar/Cu(111) was studied using van der Waals corrected density functional calculations. An attraction-induced zero friction, which is a signal of superlubricity, was found for the sliding systems. The superlubric state results from the disappearance of the potential corrugation along the favored sliding path as a consequence of the potential crossing in the attractive regime when the interfacial pressure approaches a critical-value. The finding of an attraction-driven friction drop, together with the repulsion-induced collapse in the high-load regime, which breaks down the classic Amonton's law, provides a distinct approach for the realization of inherent superlubricity in some adsorbate/substrate interfaces.

Nanoparticle Delivery of Artesunate Enhances the Anti-tumor Efficiency by Activating Mitochondria-Mediated Cell Apoptosis

NASA Astrophysics Data System (ADS)

Liu, Rui; Yu, Xiwei; Su, Chang; Shi, Yijie; Zhao, Liang

2017-06-01

Artemisinin and its derivatives were considered to exert a broad spectrum of anti-cancer activities, and they induced significant anti-cancer effects in tumor cells. Artemisinin and its derivatives could be absorbed quickly, and they were widely distributed, selectively killing tumor cells. Since low concentrations of artesunate primarily depended on oncosis to induce cell death in tumor cells, its anti-tumor effects were undesirable and limited. To obtain better anti-tumor effects, in this study, we took advantage of a new nanotechnology to design novel artesunate-loaded bovine serum albumin nanoparticles to achieve the mitochondrial accumulation of artesunate and induce mitochondrial-mediated apoptosis. The results showed that when compared with free artesunate's reliance on oncotic death, artesunate-loaded bovine serum albumin nanoparticles showed higher cytotoxicity and their significant apoptotic effects were induced through the distribution of artesunate in the mitochondria. This finding indicated that artesunate-loaded bovine serum albumin nanoparticles damaged the mitochondrial integrity and activated mitochondrial-mediated cell apoptosis by upregulating apoptosis-related proteins and facilitating the rapid release of cytochrome C.

Exosomal cancer immunotherapy is independent of MHC molecules on exosomes.

PubMed

Hiltbrunner, Stefanie; Larssen, Pia; Eldh, Maria; Martinez-Bravo, Maria-Jose; Wagner, Arnika K; Karlsson, Mikael C I; Gabrielsson, Susanne

2016-06-21

Peptide-loaded exosomes are promising cancer treatment vehicles; however, moderate T cell responses in human clinical trials indicate a need to further understand exosome-induced immunity. We previously demonstrated that antigen-loaded exosomes carry whole protein antigens and require B cells for inducing antigen-specific T cells. Therefore, we investigated the relative importance of exosomal major histocompatibility complex (MHC) class I for the induction of antigen-specific T cell responses and tumour protection. We show that ovalbumin-loaded dendritic cell-derived exosomes from MHCI-/- mice induce antigen-specific T cells at the same magnitude as wild type exosomes. Furthermore, exosomes lacking MHC class I, as well as exosomes with both MHC class I and II mismatch, induced tumour infiltrating T cells and increased overall survival to the same extent as syngeneic exosomes in B16 melanoma. In conclusion, T cell responses are independent of exosomal MHC/peptide complexes if whole antigen is present. This establishes the prospective of using impersonalised exosomes, and will greatly increase the feasibility of designing exosome-based vaccines or therapeutic approaches in humans.

Gentamicin-loaded borate bioactive glass eradicates osteomyelitis due to Escherichia coli in a rabbit model.

PubMed

Xie, Zongping; Cui, Xu; Zhao, Cunju; Huang, Wenhai; Wang, Jianqiang; Zhang, Changqing

2013-07-01

The treatment of osteomyelitis induced by Gram-negative bacilli is rarely reported in the literature. This study established a rabbit tibia model of osteomyelitis induced by the Gram-negative bacillus Escherichia coli. Using this model, pellets composed of a chitosan-bonded mixture of borate bioactive glass and gentamicin were evaluated in vitro and in vivo for the treatment of osteomyelitis induced by Escherichia coli. Our results showed that the pellets in phosphate-buffered saline released gentamicin continuously over 26 days. Without the simultaneous use of a systemic antibiotic, the implantation of the gentamicin-loaded pellets into the osteomyelitis region of the tibia resulted in the eradication of 81.82% of infections, as determined by microbiological, histological and radiographic evaluation, and supported the ingrowth of new bone into the tibia defects after 6 weeks of implantation. The results indicate that the gentamicin-loaded borate bioactive glass implant, combining sustained drug release with the ability to support new bone formation, could provide a method for treating osteomyelitis induced by Gram-negative bacilli.

Gentamicin-Loaded Borate Bioactive Glass Eradicates Osteomyelitis Due to Escherichia coli in a Rabbit Model

PubMed Central

Xie, Zongping; Cui, Xu; Zhao, Cunju; Huang, Wenhai; Wang, Jianqiang

2013-01-01

The treatment of osteomyelitis induced by Gram-negative bacilli is rarely reported in the literature. This study established a rabbit tibia model of osteomyelitis induced by the Gram-negative bacillus Escherichia coli. Using this model, pellets composed of a chitosan-bonded mixture of borate bioactive glass and gentamicin were evaluated in vitro and in vivo for the treatment of osteomyelitis induced by Escherichia coli. Our results showed that the pellets in phosphate-buffered saline released gentamicin continuously over 26 days. Without the simultaneous use of a systemic antibiotic, the implantation of the gentamicin-loaded pellets into the osteomyelitis region of the tibia resulted in the eradication of 81.82% of infections, as determined by microbiological, histological and radiographic evaluation, and supported the ingrowth of new bone into the tibia defects after 6 weeks of implantation. The results indicate that the gentamicin-loaded borate bioactive glass implant, combining sustained drug release with the ability to support new bone formation, could provide a method for treating osteomyelitis induced by Gram-negative bacilli. PMID:23629702

A hybrid deterministic-probabilistic approach to model the mechanical response of helically arranged hierarchical strands

NASA Astrophysics Data System (ADS)

Fraldi, M.; Perrella, G.; Ciervo, M.; Bosia, F.; Pugno, N. M.

2017-09-01

Very recently, a Weibull-based probabilistic strategy has been successfully applied to bundles of wires to determine their overall stress-strain behaviour, also capturing previously unpredicted nonlinear and post-elastic features of hierarchical strands. This approach is based on the so-called "Equal Load Sharing (ELS)" hypothesis by virtue of which, when a wire breaks, the load acting on the strand is homogeneously redistributed among the surviving wires. Despite the overall effectiveness of the method, some discrepancies between theoretical predictions and in silico Finite Element-based simulations or experimental findings might arise when more complex structures are analysed, e.g. helically arranged bundles. To overcome these limitations, an enhanced hybrid approach is proposed in which the probability of rupture is combined with a deterministic mechanical model of a strand constituted by helically-arranged and hierarchically-organized wires. The analytical model is validated comparing its predictions with both Finite Element simulations and experimental tests. The results show that generalized stress-strain responses - incorporating tension/torsion coupling - are naturally found and, once one or more elements break, the competition between geometry and mechanics of the strand microstructure, i.e. the different cross sections and helical angles of the wires in the different hierarchical levels of the strand, determines the no longer homogeneous stress redistribution among the surviving wires whose fate is hence governed by a "Hierarchical Load Sharing" criterion.

Optimizing ROOT’s Performance Using C++ Modules

NASA Astrophysics Data System (ADS)

Vassilev, Vassil

2017-10-01

ROOT comes with a C++ compliant interpreter cling. Cling needs to understand the content of the libraries in order to interact with them. Exposing the full shared library descriptors to the interpreter at runtime translates into increased memory footprint. ROOT’s exploratory programming concepts allow implicit and explicit runtime shared library loading. It requires the interpreter to load the library descriptor. Re-parsing of descriptors’ content has a noticeable effect on the runtime performance. Present state-of-art lazy parsing technique brings the runtime performance to reasonable levels but proves to be fragile and can introduce correctness issues. An elegant solution is to load information from the descriptor lazily and in a non-recursive way. The LLVM community advances its C++ Modules technology providing an io-efficient, on-disk representation capable to reduce build times and peak memory usage. The feature is standardized as a C++ technical specification. C++ Modules are a flexible concept, which can be employed to match CMS and other experiments’ requirement for ROOT: to optimize both runtime memory usage and performance. Cling technically “inherits” the feature, however tweaking it to ROOT scale and beyond is a complex endeavor. The paper discusses the status of the C++ Modules in the context of ROOT, supported by few preliminary performance results. It shows a step-by-step migration plan and describes potential challenges which could appear.

Steady-state signatures of visual perceptual load, multimodal distractor filtering, and neural competition.

PubMed

Parks, Nathan A; Hilimire, Matthew R; Corballis, Paul M

2011-05-01

The perceptual load theory of attention posits that attentional selection occurs early in processing when a task is perceptually demanding but occurs late in processing otherwise. We used a frequency-tagged steady-state evoked potential paradigm to investigate the modality specificity of perceptual load-induced distractor filtering and the nature of neural-competitive interactions between task and distractor stimuli. EEG data were recorded while participants monitored a stream of stimuli occurring in rapid serial visual presentation (RSVP) for the appearance of previously assigned targets. Perceptual load was manipulated by assigning targets that were identifiable by color alone (low load) or by the conjunction of color and orientation (high load). The RSVP task was performed alone and in the presence of task-irrelevant visual and auditory distractors. The RSVP stimuli, visual distractors, and auditory distractors were "tagged" by modulating each at a unique frequency (2.5, 8.5, and 40.0 Hz, respectively), which allowed each to be analyzed separately in the frequency domain. We report three important findings regarding the neural mechanisms of perceptual load. First, we replicated previous findings of within-modality distractor filtering and demonstrated a reduction in visual distractor signals with high perceptual load. Second, auditory steady-state distractor signals were unaffected by manipulations of visual perceptual load, consistent with the idea that perceptual load-induced distractor filtering is modality specific. Third, analysis of task-related signals revealed that visual distractors competed with task stimuli for representation and that increased perceptual load appeared to resolve this competition in favor of the task stimulus.

Peripheral Pain Enhances the Effects of Incentive Downshifts

ERIC Educational Resources Information Center

Ortega, Leonardo A.; Daniel, Alan M.; Davis, Jessica B.; Fuchs, Perry N.; Papini, Mauricio R.

2011-01-01

Physical pain (induced by tissue damage) and psychological pain (induced by surprising incentive loss) share a set of common neural substrates, but little is known about their interactions. The present research studied such interactions using the formalin test to induce physical pain and consummatory successive negative contrast (cSNC) to induce…

Vortex-induced dynamic loads on a non-spinning volleyball

NASA Astrophysics Data System (ADS)

Qing-ding, Wei; Rong-sheng, Lin; Zhi-jie, Liu

1988-09-01

An experiment on vortex-induced dynamic loads on a non-spinning Volleyball was conducted in a wind tunnel. The flow past the Volleyball was visualized, and the aerodynamic load was measured by use of a strain gauge balance. The separation on the Volleyball was measured with hot-film. The experimental results suggest that under the action of an unstable tail vortex system the separation region is changeable, and that the fluctuation of drag and lateral forces is the same order of magnitude as the mean drag, no matter whether the seam of the Volleyball is symmetric or asymmetric, with regard to the flow. Based on the experimental data a numerical simulation of Volleyball swerve motion was made.

Interaction of threat and verbal working memory in adolescents.

PubMed

Patel, Nilam; Vytal, Katherine; Pavletic, Nevia; Stoodley, Catherine; Pine, Daniel S; Grillon, Christian; Ernst, Monique

2016-04-01

Threat induces a state of sustained anxiety that can disrupt cognitive processing, and, reciprocally, cognitive processing can modulate an anxiety response to threat. These effects depend on the level of cognitive engagement, which itself varies as a function of task difficulty. In adults, we recently showed that induced anxiety impaired working memory accuracy at low and medium but not high load. Conversely, increasing the task load reduced the physiological correlates of anxiety (anxiety-potentiated startle). The present work examines such threat-cognition interactions as a function of age. We expected threat to more strongly impact working memory in younger individuals by virtue of putatively restricted cognitive resources and weaker emotion regulation. This was tested by examining the influence of age on the interaction of anxiety and working memory in 25 adolescents (10 to 17 years) and 25 adults (22 to 46 years). Working memory load was manipulated using a verbal n-back task. Anxiety was induced using the threat of an aversive loud scream and measured via eyeblink startle. Findings revealed that, in both age groups, accuracy was lower during threat than safe conditions at low and medium but not high load, and reaction times were faster during threat than safe conditions at high load but did not differ at other loads. Additionally, anxiety-potentiated startle was greater during low and medium than high load. Thus, the interactions of anxiety with working memory appear similar in adolescents and adults. Whether these similarities reflect common neural mechanisms would need to be assessed using functional neuroimaging. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.

Inducing Lactation: Breastfeeding for Adoptive Moms

MedlinePlus

... Español Text Size Email Print Share Inducing Lactation: Breastfeeding for Adoptive Moms Page Content Article Body A ... a breastfeeding relationship while further stimulating milk production. Nursing Supplement While there is no way to predict ...

Formation of functional gap junctions in amniotic fluid-derived stem cells induced by transmembrane co-culture with neonatal rat cardiomyocytes

PubMed Central

Connell, Jennifer Petsche; Augustini, Emily; Moise, Kenneth J; Johnson, Anthony; Jacot, Jeffrey G

2013-01-01

Amniotic fluid-derived stem cells (AFSC) have been reported to differentiate into cardiomyocyte-like cells and form gap junctions when directly mixed and cultured with neonatal rat ventricular myocytes (NRVM). This study investigated whether or not culture of AFSC on the opposite side of a Transwell membrane from NRVM, allowing for contact and communication without confounding factors such as cell fusion, could direct cardiac differentiation and enhance gap junction formation. Results were compared to shared media (Transwell), conditioned media and monoculture media controls. After a 2-week culture period, AFSC did not express cardiac myosin heavy chain or troponin T in any co-culture group. Protein expression of cardiac calsequestrin 2 was up-regulated in direct transmembrane co-cultures and media control cultures compared to the other experimental groups, but all groups were up-regulated compared with undifferentiated AFSC cultures. Gap junction communication, assessed with a scrape-loading dye transfer assay, was significantly increased in direct transmembrane co-cultures compared to all other conditions. Gap junction communication corresponded with increased connexin 43 gene expression and decreased phosphorylation of connexin 43. Our results suggest that direct transmembrane co-culture does not induce cardiomyocyte differentiation of AFSC, though calsequestrin expression is increased. However, direct transmembrane co-culture does enhance connexin-43-mediated gap junction communication between AFSC. PMID:23634988

Load redistribution in walking and trotting Beagles with induced forelimb lameness.

PubMed

Abdelhadi, Jalal; Wefstaedt, Patrick; Galindo-Zamora, Vladimir; Anders, Alexandra; Nolte, Ingo; Schilling, Nadja

2013-01-01

To evaluate the load redistribution mechanisms in walking and trotting dogs with induced forelimb lameness. 7 healthy adult Beagles. Dogs walked and trotted on an instrumented treadmill to determine control values for peak and mean vertical force as well as vertical impulse for all 4 limbs. A small sphere was attached to the ventral pad of the right forelimb paw to induce a reversible lameness, and recordings were repeated for both gaits. Additionally, footfall patterns were assessed to test for changes in temporal gait variables. During walking and trotting, peak and mean vertical force as well as vertical impulse were decreased in the ipsilateral forelimb, increased in the contralateral hind limb, and remained unchanged in the ipsilateral hind limb after lameness was induced. All 3 variables were increased in the contralateral forelimb during trotting, whereas only mean vertical force and vertical impulse were increased during walking. Stance phase duration increased in the contralateral forelimb and hind limb during walking but not during trotting. Analysis of the results suggested that compensatory load redistribution mechanisms in dogs depend on the gait. All 4 limbs should be evaluated in basic research and clinical studies to determine the effects of lameness on the entire body. Further studies are necessary to elucidate specific mechanisms for unloading of the affected limb and to determine the long-term effects of load changes in animals with chronic lameness.

SSME alternate turbopump (pump section) axial load analysis

NASA Technical Reports Server (NTRS)

Crease, G. A.; Rosello, A., Jr.; Fetfatsidis, A. K.

1989-01-01

A flow balancing computer program constructed to calculate the axial loads on the Space Shuttle Main Engine (SSME) alternate turbopumps (ATs) pump sections are described. The loads are used in turn to determine load balancing piston design requirements. The application of the program to the inlet section, inducer/impeller/stage, bearings, seals, labyrinth, damper, piston, face and corner, and stationary/rotating surfaces is indicated. Design analysis results are reported which show that the balancing piston's designs are adequate and that performance and life will not be degraded by the turbopump's axial load characteristics.

Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms.

PubMed

Cruchaga, Carlos; Del-Aguila, Jorge L; Saef, Benjamin; Black, Kathleen; Fernandez, Maria Victoria; Budde, John; Ibanez, Laura; Deming, Yuetiva; Kapoor, Manav; Tosto, Giuseppe; Mayeux, Richard P; Holtzman, David M; Fagan, Anne M; Morris, John C; Bateman, Randall J; Goate, Alison M; Harari, Oscar

2018-02-01

To determine whether the extent of overlap of the genetic architecture among the sporadic late-onset Alzheimer's Disease (sLOAD), familial late-onset AD (fLOAD), sporadic early-onset AD (sEOAD), and autosomal dominant early-onset AD (eADAD). Polygenic risk scores (PRSs) were constructed using previously identified 21 genome-wide significant loci for LOAD risk. We found that there is an overlap in the genetic architecture among sEOAD, fLOAD, and sLOAD. The highest association of the PRS and risk (odds ratio [OR] = 2.27; P = 1.29 × 10 -7 ) was observed in sEOAD, followed by fLOAD (OR = 1.75; P = 1.12 × 10 -7 ) and sLOAD (OR = 1.40; P = 1.21 × 10 -3 ). The PRS was associated with cerebrospinal fluid ptau 181 -Aβ 42 on eADAD (P = 4.36 × 10 -2 ). Our analysis confirms that the genetic factors identified for LOAD modulate risk in sLOAD and fLOAD and also sEOAD cohorts. Specifically, our results suggest that the burden of these risk variants is associated with familial clustering and earlier onset of AD. Although these variants are not associated with risk in the eADAD, they may be modulating age at onset. Copyright © 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

High Pressure Oxidizer Turbopump (HPOTP) inducer dynamic design environment

NASA Technical Reports Server (NTRS)

Herda, D. A.; Gross, R. S.

1995-01-01

The dynamic environment must be known to evaluate high pressure oxidizer turbopump inducer fatigue life. This report sets the dynamic design loads for the alternate turbopump inducer as determined by water-flow rig testing. Also, guidelines are given for estimating the dynamic environment for other inducer and impeller applications.

Effect of Mood on Children's Giving.

ERIC Educational Resources Information Center

Underwood, Bill; And Others

1972-01-01

An experiment was conducted to clarify the relations between affect and altruism by inducing affect directly. It was hypothesized that children who experienced positive affect would share more than controls, while those experiencing negative affect would share significantly less than controls. Ss were 25 girls and 18 boys from the second and third…

In situ spectroscopic study of the plastic deformation of amorphous silicon under nonhydrostatic conditions induced by indentation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gerbig, Yvonne B.; Michaels, C. A.; Bradby, Jodie E.

Indentation-induced plastic deformation of amorphous silicon (a-Si) thin films was studied by in situ Raman imaging of the deformed contact region of an indented sample, employing a Raman spectroscopy-enhanced instrumented indentation technique (IIT). The occurrence and evolving spatial distribution of changes in the a-Si structure caused by processes, such as polyamorphization and crystallization, induced by indentation loading were observed. Furthermore, the obtained experimental results are linked with previously published work on the plastic deformation of a-Si under hydrostatic compression and shear deformation to establish a model for the deformation behavior of a-Si under indentation loading.

In situ spectroscopic study of the plastic deformation of amorphous silicon under nonhydrostatic conditions induced by indentation

DOE PAGES

Gerbig, Yvonne B.; Michaels, C. A.; Bradby, Jodie E.; ...

2015-12-17

Indentation-induced plastic deformation of amorphous silicon (a-Si) thin films was studied by in situ Raman imaging of the deformed contact region of an indented sample, employing a Raman spectroscopy-enhanced instrumented indentation technique (IIT). The occurrence and evolving spatial distribution of changes in the a-Si structure caused by processes, such as polyamorphization and crystallization, induced by indentation loading were observed. Furthermore, the obtained experimental results are linked with previously published work on the plastic deformation of a-Si under hydrostatic compression and shear deformation to establish a model for the deformation behavior of a-Si under indentation loading.

Static test induced loads verification beyond elastic limit

NASA Technical Reports Server (NTRS)

Verderaime, V.; Harrington, F.

1996-01-01

Increasing demands for reliable and least-cost high-performance aerostructures are pressing design analyses, materials, and manufacturing processes to new and narrowly experienced performance and verification technologies. This study assessed the adequacy of current experimental verification of the traditional binding ultimate safety factor which covers rare events in which no statistical design data exist. Because large high-performance structures are inherently very flexible, boundary rotations and deflections under externally applied loads approaching fracture may distort their transmission and unknowingly accept submarginal structures or prematurely fracturing reliable ones. A technique was developed, using measured strains from back-to-back surface mounted gauges, to analyze, define, and monitor induced moments and plane forces through progressive material changes from total-elastic to total-inelastic zones within the structural element cross section. Deviations from specified test loads are identified by the consecutively changing ratios of moment-to-axial load.

Static test induced loads verification beyond elastic limit

NASA Technical Reports Server (NTRS)

Verderaime, V.; Harrington, F.

1996-01-01

Increasing demands for reliable and least-cost high performance aerostructures are pressing design analyses, materials, and manufacturing processes to new and narrowly experienced performance and verification technologies. This study assessed the adequacy of current experimental verification of the traditional binding ultimate safety factor which covers rare events in which no statistical design data exist. Because large, high-performance structures are inherently very flexible, boundary rotations and deflections under externally applied loads approaching fracture may distort their transmission and unknowingly accept submarginal structures or prematurely fracturing reliable ones. A technique was developed, using measured strains from back-to-back surface mounted gauges, to analyze, define, and monitor induced moments and plane forces through progressive material changes from total-elastic to total inelastic zones within the structural element cross section. Deviations from specified test loads are identified by the consecutively changing ratios of moment-to-axial load.

Sonic-boom-induced building structure responses including damage.

NASA Technical Reports Server (NTRS)

Clarkson, B. L.; Mayes, W. H.

1972-01-01

Concepts of sonic-boom pressure loading of building structures and the associated responses are reviewed, and results of pertinent theoretical and experimental research programs are summarized. The significance of sonic-boom load time histories, including waveshape effects, are illustrated with the aid of simple structural elements such as beams and plates. Also included are discussions of the significance of such other phenomena as three-dimensional loading effects, air cavity coupling, multimodal responses, and structural nonlinearities. Measured deflection, acceleration, and strain data from laboratory models and full-scale building tests are summarized, and these data are compared, where possible, with predicted values. Damage complaint and claim experience due both to controlled and uncontrolled supersonic flights over communities are summarized with particular reference to residential, commercial, and historic buildings. Sonic-boom-induced building responses are compared with those from other impulsive loadings due to natural and cultural events and from laboratory simulation tests.

The effects of quercetin-loaded PLGA-TPGS nanoparticles on ultraviolet B-induced skin damages in vivo.

PubMed

Zhu, Xianbing; Zeng, Xiaowei; Zhang, Xudong; Cao, Wei; Wang, Yilin; Chen, Houjie; Wang, Teng; Tsai, Hsiang-I; Zhang, Ran; Chang, Danfeng; He, Shuai; Mei, Lin; Shi, Xiaojun

2016-04-01

Ultraviolet (UV) radiation has deleterious effects on living organisms, and functions as a tumor initiator and promoter. Multiple natural compounds, like quercetin, have been shown the protective effects on UV-induced damage. However, quercetin is extremely hydrophobic and limited by its poor percutaneous permeation and skin deposition. Here, we show that quercetin-loaded PLGA-TPGS nanoparticles could overcome low hydrophilicity of quercetin and improve its anti-UVB effect. Quercetin-loaded NPs can significantly block UVB irradiation induced COX-2 up-expression and NF-kB activation in Hacat cell line. Moreover, PLGA-TPGS NPs could efficiently get through epidermis and reach dermis. Treatment of mice with quercetin-loaded NPs also attenuates UVB irradiation-associated macroscopic and histopathological changes in mice skin. These results demonstrated that copolymer PLGA-TPGS could be used as drug nanocarriers against skin damage and disease. The findings provide an external use of PLGA-TPGS nanocarriers for application in the treatment of skin diseases. Skin is the largest organ in the body and is subjected to ultraviolet (UV) radiation damage daily from the sun. Excessive exposure has been linked to the development of skin cancer. Hence, topically applied agents can play a major role in skin protection. In this article, the authors developed quercetin-loaded PLGA-TPGS nanoparticles and showed their anti-UVB effect. Copyright © 2015 Elsevier Inc. All rights reserved.

Critical and subcritical damage monitoring of bonded composite repairs using innovative non-destructive techniques

NASA Astrophysics Data System (ADS)

Grammatikos, S. A.; Kordatos, E. Z.; Aggelis, D. G.; Matikas, T. E.; Paipetis, A. S.

2012-04-01

Infrared Thermography (IrT) has been shown to be capable of detecting and monitoring service induced damage of repair composite structures. Full-field imaging, along with portability are the primary benefits of the thermographic technique. On-line lock-in thermography has been reported to successfully monitor damage propagation or/and stress concentration in composite coupons, as mechanical stresses in structures induce heat concentration phenomena around flaws. During mechanical fatigue, cyclic loading plays the role of the heating source and this allows for critical and subcritical damage identification and monitoring using thermography. The Electrical Potential Change Technique (EPCT) is a new method for damage identification and monitoring during loading. The measurement of electrical potential changes at specific points of Carbon Fiber Reinforced Polymers (CFRPs) under load are reported to enable the monitoring of strain or/and damage accumulation. Along with the aforementioned techniques Finally, Acoustic Emission (AE) method is well known to provide information about the location and type of damage. Damage accumulation due to cyclic loading imposes differentiation of certain parameters of AE like duration and energy. Within the scope of this study, infrared thermography is employed along with AE and EPCT methods in order to assess the integrity of bonded repair patches on composite substrates and to monitor critical and subcritical damage induced by the mechanical loading. The combined methodologies were effective in identifying damage initiation and propagation of bonded composite repairs.

Locomotion with Loads: Practical Techniques for Predicting Performance Outcomes

DTIC Science & Technology

2013-05-01

Lotens (1992) who reported that a load equal to 21% of body weight reduced all-out running velocities by 13 and 18% for all-out 80- and 400 - meter runs...hypothesize second that the speed-load carriage algorithms will allow load- induced decrements in all-out sprint running speeds to be predicted to within...1968; Santee et al., 2001) may then be explored in the context of the model. Objective Two: Sprint Running Speed Previous Scientific Efforts

Microspheres for the oral delivery of insulin: preparation, evaluation and hypoglycaemic effect in streptozotocin-induced diabetic rats.

PubMed

Zhang, Huan; Wang, Weimei; Li, Haoran; Peng, Yi; Zhang, Zhiqing

2018-01-01

Insulin-loaded microspheres were prepared by alternating deposition film layers that were composed of insulin and poly(vinyl sulfate) potassium on the surface of poly(lactic acid) (PLA) microspheres. The preparation of the insulin-loaded microspheres was optimized by an orthogonal test design, and the relationship between drug loading (DL) and film layers was studied. The particle size, DL and encapsulation efficiency of the obtained insulin-loaded microspheres with 10 films were 5.25 ± 0.15 µm, 111.33 ± 1.15 mg/g and 33.7 ± 0.19%, respectively. Following this, the physical characteristics of the insulin-loaded microspheres were investigated. The results from scanning electron microscopy and a laser particle size analyzer (LPSA) indicated the spherical morphology, rough surface and increasing particle sizes of the insulin-loaded microspheres, which were compared to those of PLA microspheres. An in vitro release study showed that the insulin-loaded microspheres were stable in HCl solution (pH 1.0) and released insulin slowly in phosphate-buffered solution (pH 6.8). Finally, the drug efficacy of the prepared insulin-loaded microspheres via oral administration was evaluated in rats with diabetes induced by streptozotocin, and an obvious dose-dependent hypoglycemic effect was observed. This preliminary data could illustrate the prospect of using microspheres for the oral delivery of insulin.

Blasting response of the Eiffel Tower

NASA Astrophysics Data System (ADS)

Horlyck, Lachlan; Hayes, Kieran; Caetano, Ryan; Tahmasebinia, Faham; Ansourian, Peter; Alonso-Marroquin, Fernando

2016-08-01

A finite element model of the Eiffel Tower was constructed using Strand7 software. The model replicates the existing tower, with dimensions justified through the use of original design drawings. A static and dynamic analysis was conducted to determine the actions of the tower under permanent, imposed and wind loadings, as well as under blast pressure loads and earthquake loads due to an explosion. It was observed that the tower utilises the full axial capacity of individual members by acting as a `truss of trusses'. As such, permanent and imposed loads are efficiently transferred to the primary columns through compression, while wind loads induce tensile forces in the windward legs and compressive forces in the leeward. Under blast loading, the tower experienced both ground vibrations and blast pressures. Ground vibrations induced a negligibly small earthquake loading into the structure which was ignored in subsequent analyses. The blast pressure was significant, and a dynamic analysis of this revealed that further research is required into the damping qualities of the structure due to soil and mechanical properties. In the worst case scenario, the blast was assumed to completely destroy several members in the adjacent leg. Despite this weakened condition, it was observed that the tower would still be able to sustain static loads, at least for enough time for occupant evacuation. Further, an optimised design revealed the structure was structurally sound under a 46% reduction of the metal tower's mass.

Perceptual load influences selective attention across development.

PubMed

Couperus, Jane W

2011-09-01

Research suggests that visual selective attention develops across childhood. However, there is relatively little understanding of the neurological changes that accompany this development, particularly in the context of adult theories of selective attention, such as N. Lavie's (1995) perceptual load theory of attention. This study examined visual selective attention across development from 7 years of age to adulthood. Specifically, the author examined if changes in processing as a function of selective attention are similarly influenced by perceptual load across development. Participants were asked to complete a task at either low or high perceptual load while processing of an unattended probe stimulus was examined using event related potentials. Similar to adults, children and teens showed reduced processing of the unattended stimulus as perceptual load increased at the P1 visual component. However, although there were no qualitative differences in changes in processing, there were quantitative differences, with shorter P1 latencies in teens and adults compared with children, suggesting increases in the speed of processing across development. In addition, younger children did not need as high a perceptual load to achieve the same difference in performance between low and high perceptual load as adults. Thus, this study demonstrates that although there are developmental changes in visual selective attention, the mechanisms by which visual selective attention is achieved in children may share similarities with adults.

Global Cryptosporidium Loads from Livestock Manure

PubMed Central

2017-01-01

Understanding the environmental pathways of Cryptosporidium is essential for effective management of human and animal cryptosporidiosis. In this paper we aim to quantify livestock Cryptosporidium spp. loads to land on a global scale using spatially explicit process-based modeling, and to explore the effect of manure storage and treatment on oocyst loads using scenario analysis. Our model GloWPa-Crypto L1 calculates a total global Cryptosporidium spp. load from livestock manure of 3.2 × 1023 oocysts per year. Cattle, especially calves, are the largest contributors, followed by chickens and pigs. Spatial differences are linked to animal spatial distributions. North America, Europe, and Oceania together account for nearly a quarter of the total oocyst load, meaning that the developing world accounts for the largest share. GloWPa-Crypto L1 is most sensitive to oocyst excretion rates, due to large variation reported in literature. We compared the current situation to four alternative management scenarios. We find that although manure storage halves oocyst loads, manure treatment, especially of cattle manure and particularly at elevated temperatures, has a larger load reduction potential than manure storage (up to 4.6 log units). Regions with high reduction potential include India, Bangladesh, western Europe, China, several countries in Africa, and New Zealand. PMID:28654242

Validation of Vortex-Lattice Method for Loads on Wings in Lift-Generated Wakes

NASA Technical Reports Server (NTRS)

Rossow, Vernon J.

1995-01-01

A study is described that evaluates the accuracy of vortex-lattice methods when they are used to compute the loads induced on aircraft as they encounter lift-generated wakes. The evaluation is accomplished by the use of measurements made in the 80 by 120 ft Wind Tunnel of the lift, rolling moment, and downwash in the wake of three configurations of a model of a subsonic transport aircraft. The downwash measurements are used as input for a vortex-lattice code in order to compute the lift and rolling moment induced on wings that have a span of 0.186, 0.510, or 1.022 times the span of the wake-generating model. Comparison of the computed results with the measured lift and rolling-moment distributions the vortex-lattice method is very reliable as long as the span of the encountering or following wing is less than about 0.2 of the generator span. As the span of the following wing increases above 0.2, the vortex-lattice method continues to correctly predict the trends and nature of the induced loads, but it overpredicts the magnitude of the loads by increasing amounts.

A Comparative Analysis of Wiki Discretionary Access Control in a CONOPS Environment

DTIC Science & Technology

2008-12-01

always light at the end of the tunnel . Last but not less, the author would like to share the success of the completion of this thesis research...modern clients (e.g. Blackberries , iPhones, tactical digital assistants like the TACTICOMP), wikis do not require extensive user training or loading of

Honeycomb chassis for electronic components

NASA Technical Reports Server (NTRS)

Read, W. S.; Stebbins, B. W.

1977-01-01

In new electronic chassis support, machined honeycomb members are used to change basic relationship between chassis and support structure. Improved chassis combines internal and external support and heat dissipation by altering chassis internal geometry. Honeycomb materials allow mechanical support and thermal load sharing to be combined at lower weight and lower cost than previous equipment.

Risky Business or Sharing the Load?--Social Flow in Collaborative Mobile Learning

ERIC Educational Resources Information Center

Ryu, Hokyoung; Parsons, David

2012-01-01

Mobile learning has been built upon the premise that we can transform traditional classroom or computer-based learning activities into a more ubiquitous and connected form of learning. Tentative outcomes from this assertion have been witnessed in many collaborative learning activities, but few analytic observations on what triggers this…

Quietly Sharing the Load? The Role of School Psychologists in Enabling Teacher Resilience

ERIC Educational Resources Information Center

Beltman, Susan; Mansfield, Caroline F.; Harris, Annabelle

2016-01-01

Teacher resilience is associated with positive student outcomes and plays an important role in teacher retention and well-being. School ecologies can enable the resilience of teachers, with prior research illustrating the importance of supportive colleagues, strong leadership, and positive school culture. There is limited research, however,…

33 CFR Appendix B to Part 277 - Hypothetical Example of Cost Apportionment

Code of Federal Regulations, 2013 CFR

2013-07-01

...) $165,489 I b. Fixed charges (owner's share) 284,460 II A fixed charge such as engineering, design and... new bridge is designed for increased loading and width greater than that of the old bridge. Therefore, the estimated annual maintenance cost was based on a hypothetical bridge designed, but not constructed...

33 CFR Appendix B to Part 277 - Hypothetical Example of Cost Apportionment

Code of Federal Regulations, 2014 CFR

2014-07-01

...) $165,489 I b. Fixed charges (owner's share) 284,460 II A fixed charge such as engineering, design and... new bridge is designed for increased loading and width greater than that of the old bridge. Therefore, the estimated annual maintenance cost was based on a hypothetical bridge designed, but not constructed...

33 CFR Appendix B to Part 277 - Hypothetical Example of Cost Apportionment

Code of Federal Regulations, 2010 CFR

2010-07-01

...) $165,489 I b. Fixed charges (owner's share) 284,460 II A fixed charge such as engineering, design and... new bridge is designed for increased loading and width greater than that of the old bridge. Therefore, the estimated annual maintenance cost was based on a hypothetical bridge designed, but not constructed...

33 CFR Appendix B to Part 277 - Hypothetical Example of Cost Apportionment

Code of Federal Regulations, 2011 CFR

2011-07-01

...) $165,489 I b. Fixed charges (owner's share) 284,460 II A fixed charge such as engineering, design and... new bridge is designed for increased loading and width greater than that of the old bridge. Therefore, the estimated annual maintenance cost was based on a hypothetical bridge designed, but not constructed...

33 CFR Appendix B to Part 277 - Hypothetical Example of Cost Apportionment

Code of Federal Regulations, 2012 CFR

2012-07-01

...) $165,489 I b. Fixed charges (owner's share) 284,460 II A fixed charge such as engineering, design and... new bridge is designed for increased loading and width greater than that of the old bridge. Therefore, the estimated annual maintenance cost was based on a hypothetical bridge designed, but not constructed...

DEVELOPMENT OF ASME SECTION X CODE RULES FOR HIGH PRESSURE COMPOSITE HYDROGEN PRESSURE VESSELS WITH NON-LOAD SHARING LINERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rawls, G.; Newhouse, N.; Rana, M.

2010-04-13

The Boiler and Pressure Vessel Project Team on Hydrogen Tanks was formed in 2004 to develop Code rules to address the various needs that had been identified for the design and construction of up to 15000 psi hydrogen storage vessel. One of these needs was the development of Code rules for high pressure composite vessels with non-load sharing liners for stationary applications. In 2009, ASME approved new Appendix 8, for Section X Code which contains the rules for these vessels. These vessels are designated as Class III vessels with design pressure ranging from 20.7 MPa (3,000 ps)i to 103.4 MPamore » (15,000 psi) and maximum allowable outside liner diameter of 2.54 m (100 inches). The maximum design life of these vessels is limited to 20 years. Design, fabrication, and examination requirements have been specified, included Acoustic Emission testing at time of manufacture. The Code rules include the design qualification testing of prototype vessels. Qualification includes proof, expansion, burst, cyclic fatigue, creep, flaw, permeability, torque, penetration, and environmental testing.« less

Novel docetaxel-loaded nanoparticles based on poly(lactide-co-caprolactone) and poly(lactide-co-glycolide-co-caprolactone) for prostate cancer treatment: formulation, characterization, and cytotoxicity studies

NASA Astrophysics Data System (ADS)

Sanna, Vanna; Roggio, Anna Maria; Posadino, Anna Maria; Cossu, Annalisa; Marceddu, Salvatore; Mariani, Alberto; Alzari, Valeria; Uzzau, Sergio; Pintus, Gianfranco; Sechi, Mario

2011-12-01

Docetaxel (Dtx) chemotherapy is the optional treatment in patients with hormone-refractory metastatic prostate cancer, and Dtx-loaded polymeric nanoparticles (NPs) have the potential to induce durable clinical responses. However, alternative formulations are needed to overcome the serious side effects, also due to the adjuvant used, and to improve the clinical efficacy of the drug. In the present study, two novel biodegradable block-copolymers, poly(lactide-co-caprolactone) (PLA-PCL) and poly(lactide-co-caprolactone-co-glycolide) (PLGA-PCL), were explored for the formulation of Dtx-loaded NPs and compared with PLA- and PLGA-NPs. The nanosystems were prepared by an original nanoprecipitation method, using Pluronic F-127 as surfactant agent, and were characterized in terms of morphology, size distribution, encapsulation efficiency, crystalline structure, and in vitro release. To evaluate the potential anticancer efficacy of a nanoparticulate system, in vitro cytotoxicity studies on human prostate cancer cell line (PC3) were carried out. NPs were found to be of spherical shape with an average diameter in the range of 100 to 200 nm and a unimodal particle size distribution. Dtx was incorporated into the PLGA-PCL NPs with higher ( p < 0.05) encapsulation efficiency than that of other polymers. Differential scanning calorimetry suggested that Dtx was molecularly dispersed in the polymeric matrices. In vitro drug release study showed that release profiles of Dtx varied on the bases of characteristics of polymers used for formulation. PLA-PCL and PLGA-PCL drug loaded NPs shared an overlapping release profiles, and are able to release about 90% of drug within 6 h, when compared with PLA- and PLGA-NPs. Moreover, cytotoxicity studies demonstrated advantages of the Dtx-loaded PLGA-PCL NPs over pure Dtx in both time- and concentration-dependent manner. In particular, an increase of 20% of PC3 growth inhibition was determined by PLGA-PCL NPs with respect to free drug after 72 h incubation and at all tested Dtx concentration. In summary, PLGA-PCL copolymer may be considered as an attractive and promising polymeric material for the formulation of Dtx NPs as delivery system for prostate cancer treatment, and can also be pursued as a validated system in a more large context.

Characterization of the High-Speed-Stage Bearing Skidding of Wind Turbine Gearboxes Induced by Dynamic Electricity Grid Events

DOE Office of Scientific and Technical Information (OSTI.GOV)

Helsen, Jan; Guillaume, Patrick; Guo, Yi

Bearing behavior is an important factor for wind turbine drivetrain reliability. Extreme loads and dynamic excitations pose challenges to the bearing design and therefore its performance. Excessive skidding of the bearing rollers should be avoided because it can cause scuffing failures. Excitations coming from wind and the electricity grid can subject the drivetrain to fluctuating torque and nontorque loads. Wind-induced excitations have been investigated predominantly in literature. However, modern wind turbines are subjected more and more to grid-induced loads because of stricter electricity grid regulations. For example, during fault-ride-through events, turbines are required to stay connected for a longer periodmore » of time during the grid failure. This work investigates the influence of electrically induced excitations on the skidding behaviour of the tapered roller bearings on the high-speed stage of a wind turbine gearbox. This skidding behaviour during dynamic events is described as a potential bearing failure initiator by many researchers; however, only limited full-scale dynamic testing is documented. Therefore, a dedicated gridloss-type event is defined in the paper and conducted in a dynamometer test on a full-scale wind turbine nacelle. During the event, a complete electricity grid failure is simulated while the turbine is at rated speed and predefined torque levels. Particular focus is on the characterization of the high-speed shaft tapered roller bearing slip behavior. Strain-gauge bridges in grooves along the circumference of the outer ring are used to characterize the bearing load zone in detail. It is shown that during the torque reversals of the transient event, roller slip can be induced. This indicates the potential of the applied load case to go beyond the preload of the tapered roller bearing. Furthermore, the relation between the applied torque and skidding level is studied.« less

Characterization of the High-Speed-Stage Bearing Skidding of Wind Turbine Gearboxes Induced by Dynamic Electricity Grid Events: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Helsen, Jan; Guillaume, Patrick; Guo, Yi

Bearing behavior is an important factor for wind turbine drivetrain reliability. Extreme loads and dynamic excitations pose challenges to the bearing design and therefore its performance. Excessive skidding of the bearing rollers should be avoided because it can cause scuffing failures. Excitations coming from wind and the electricity grid can subject the drivetrain to fluctuating torque and nontorque loads. Wind-induced excitations have been investigated predominantly in literature. However, modern wind turbines are subjected more and more to grid-induced loads because of stricter electricity grid regulations. For example, during fault-ride-through events, turbines are required to stay connected for a longer periodmore » of time during the grid failure. This work investigates the influence of electrically induced excitations on the skidding behaviour of the tapered roller bearings on the high-speed stage of a wind turbine gearbox. This skidding behaviour during dynamic events is described as a potential bearing failure initiator by many researchers; however, only limited full-scale dynamic testing is documented. Therefore, a dedicated gridloss-type event is defined in the paper and conducted in a dynamometer test on a full-scale wind turbine nacelle. During the event, a complete electricity grid failure is simulated while the turbine is at rated speed and predefined torque levels. Particular focus is on the characterization of the high-speed shaft tapered roller bearing slip behavior. Strain-gauge bridges in grooves along the circumference of the outer ring are used to characterize the bearing load zone in detail. It is shown that during the torque reversals of the transient event, roller slip can be induced. This indicates the potential of the applied load case to go beyond the preload of the tapered roller bearing. Furthermore, the relation between the applied torque and skidding level is studied.« less

In situ nonlinear ultrasonic technique for monitoring microcracking in concrete subjected to creep and cyclic loading.

PubMed

Kim, Gun; Loreto, Giovanni; Kim, Jin-Yeon; Kurtis, Kimberly E; Wall, James J; Jacobs, Laurence J

2018-08-01

This research conducts in situ nonlinear ultrasonic (NLU) measurements for real time monitoring of load-induced damage in concrete. For the in situ measurements on a cylindrical specimen under sustained load, a previously developed second harmonic generation (SHG) technique with non-contact detection is adapted to a cylindrical specimen geometry. This new setup is validated by demonstrating that the measured nonlinear Rayleigh wave signals are equivalent to those in a flat half space, and thus the acoustic nonlinearity parameter, β can be defined and interpreted in the same way. Both the acoustic nonlinearity parameter and strain are measured to quantitatively assess the early-age damage in a set of concrete specimens subjected to either 25 days of creep, or 11 cycles of cyclic loading at room temperature. The experimental results show that the acoustic nonlinearity parameter is sensitive to early-stage microcrack formation under both loading conditions - the measured β can be directly linked to the accumulated microscale damage. This paper demonstrates the potential of NLU for the in situ monitoring of mechanical load-induced microscale damage in concrete components. Copyright © 2018 Elsevier B.V. All rights reserved.

Seasonal patterns of seismicity and deformation at the Alutu geothermal reservoir, Ethiopia, induced by hydrological loading

NASA Astrophysics Data System (ADS)

Birhanu, Yelebe; Wilks, Matthew; Biggs, Juliet; Kendall, J.-Michael; Ayele, Atalay; Lewi, Elias

2018-05-01

Seasonal variations in the seismicity of volcanic and geothermal reservoirs are usually attributed to the hydrological cycle. Here, we focus on the Aluto-Langano geothermal system, Ethiopia, where the climate is monsoonal and there is abundant shallow seismicity. We deployed temporary networks of seismometers and GPS receivers to understand the drivers of unrest. First, we show that a statistically significant peak in seismicity occurred 2-3 months after the main rainy season, with a second, smaller peak of variable timing. Seasonal seismicity is commonly attributed to variations in either surface loading or reservoir pore pressure. As loading will cause subsidence and overpressure will cause uplift, comparing seismicity rates with continuous GPS, enables us to distinguish between mechanisms. At Aluto, the major peak in seismicity is coincident with the high stand of nearby lakes and maximum subsidence, indicating that it is driven by surface loading. The magnitude of loading is insufficient to trigger widespread crustal seismicity but the geothermal reservoir at Aluto is likely sensitive to small perturbations in the stress field. Thus we demonstrate that monsoonal loading can produce seismicity in geothermal reservoirs, and the likelihood of both triggered and induced seismicity varies seasonally.

Influence of weld-induced residual stresses on the hysteretic behavior of a girth-welded circular stainless steel tube

NASA Astrophysics Data System (ADS)

Lee, Chin-Hyung; Nguyen Van Do, Vuong; Chang, Kyong-Ho; Jeon, Jun-Tai; Um, Tae-Hwan

2018-04-01

The present study attempts to characterize the relevance of welding residual stresses to the hysteretic behaviour of a girth-welded circular stainless steel tube under cyclic mechanical loadings. Finite element (FE) thermal simulation of the girth butt welding process is first performed to identify the weld-induced residual stresses by using the one-way coupled three-dimensional (3-D) thermo-mechanical FE analysis method. 3-D elastic-plastic FE analysis equipped with the cyclic plasticity constitutive model capable of describing the cyclic response is next carried out to scrutinize the effects that the residual stresses have on the hysteretic performance of the girth-welded steel tube exposed to cyclic axial loading, which takes the residual stresses and plastic strains calculated from the preceding thermo-mechanical analysis as the initial condition. The analytical results demonstrate that the residual stresses bring about premature yielding and deterioration of the load carrying capacity in the elastic and the transition load ranges, whilst the residual stress effect is wiped out quickly in the plastic load domain since the residual stresses are nearly wholly relaxed after application of the cyclic plastic loading.

Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Pathway Is Induced by Mechanical Load and Reduces the Activity of Hedgehog Signaling in Chondrogenic Micromass Cell Cultures

PubMed Central

Juhász, Tamás; Szentléleky, Eszter; Szűcs Somogyi, Csilla; Takács, Roland; Dobrosi, Nóra; Engler, Máté; Tamás, Andrea; Reglődi, Dóra; Zákány, Róza

2015-01-01

Pituitary adenylate cyclase activating polypeptide (PACAP) is a neurohormone exerting protective function during various stress conditions either in mature or developing tissues. Previously we proved the presence of PACAP signaling elements in chicken limb bud-derived chondrogenic cells in micromass cell cultures. Since no data can be found if PACAP signaling is playing any role during mechanical stress in any tissues, we aimed to investigate its contribution in mechanotransduction during chondrogenesis. Expressions of the mRNAs of PACAP and its major receptor, PAC1 increased, while that of other receptors, VPAC1, VPAC2 decreased upon mechanical stimulus. Mechanical load enhanced the expression of collagen type X, a marker of hypertrophic differentiation of chondrocytes and PACAP addition attenuated this elevation. Moreover, exogenous PACAP also prevented the mechanical load evoked activation of hedgehog signaling: protein levels of Sonic and Indian Hedgehogs and Gli1 transcription factor were lowered while expressions of Gli2 and Gli3 were elevated by PACAP application during mechanical load. Our results suggest that mechanical load activates PACAP signaling and exogenous PACAP acts against the hypertrophy inducing effect of mechanical load. PMID:26230691

Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Pathway Is Induced by Mechanical Load and Reduces the Activity of Hedgehog Signaling in Chondrogenic Micromass Cell Cultures.

PubMed

Juhász, Tamás; Szentléleky, Eszter; Somogyi, Csilla Szűcs; Takács, Roland; Dobrosi, Nóra; Engler, Máté; Tamás, Andrea; Reglődi, Dóra; Zákány, Róza

2015-07-29

Pituitary adenylate cyclase activating polypeptide (PACAP) is a neurohormone exerting protective function during various stress conditions either in mature or developing tissues. Previously we proved the presence of PACAP signaling elements in chicken limb bud-derived chondrogenic cells in micromass cell cultures. Since no data can be found if PACAP signaling is playing any role during mechanical stress in any tissues, we aimed to investigate its contribution in mechanotransduction during chondrogenesis. Expressions of the mRNAs of PACAP and its major receptor, PAC1 increased, while that of other receptors, VPAC1, VPAC2 decreased upon mechanical stimulus. Mechanical load enhanced the expression of collagen type X, a marker of hypertrophic differentiation of chondrocytes and PACAP addition attenuated this elevation. Moreover, exogenous PACAP also prevented the mechanical load evoked activation of hedgehog signaling: protein levels of Sonic and Indian Hedgehogs and Gli1 transcription factor were lowered while expressions of Gli2 and Gli3 were elevated by PACAP application during mechanical load. Our results suggest that mechanical load activates PACAP signaling and exogenous PACAP acts against the hypertrophy inducing effect of mechanical load.

Creep-induced residual stress strengthening in a Nicalon-fiber-reinforced BMAS-glass-ceramic-matrix composite

DOE Office of Scientific and Technical Information (OSTI.GOV)

Widjaja, S.; Jakus, K.; Ritter, J.E.

The feasibility of inducing a compressive residual stress in the matrix of a Nicalon-fiber-reinforced BMAS-glass-ceramic-matrix composite through a creep-load transfer treatment was studied. Specimens were crept at 1100 C under constant tensile load to cause load transfer from the matrix to the fibers, then cooled under load. Upon removal of the load at room temperature, the matrix was put into compression by the elastic recovery of the fibers. This compressive residual stress in the matrix increased the room-temperature proportional limit stress of the composite. The increase in the proportional limit stress was found to be dependent upon the applied creepmore » stress, with an increase in creep stress resulting in an increase in the proportional limit stress. Acoustic emission results showed that the onset of significant matrix cracking correlated closely to the proportional limit stress. Changes in the state of residual stress in the matrix were supported by X-ray diffraction results. Fracture surfaces of all specimens exhibited fiber pullout behavior, indicating that the creep-load transfer process did not embrittle the fiber/matrix interface.« less

Pressure-overload-induced angiotensin-mediated early remodeling in mouse heart

PubMed Central

Kim, Jeremy H.; Jiang, Ya-Ping; Cohen, Ira S.; Lin, Richard Z.; Mathias, Richard T.

2017-01-01

Our previous work on angiotensin II-mediated electrical-remodeling in canine left ventricle, in connection with a long history of other studies, suggested the hypothesis: increases in mechanical load induce autocrine secretion of angiotensin II (A2), which coherently regulates a coterie of membrane ion transporters in a manner that increases contractility. However, the relation between load and A2 secretion was correlative. We subsequently showed a similar or identical system was present in murine heart. To investigate whether the relation between mechanical load and A2-mediated electrical remodeling was causal, we employed transverse aortic constriction in mice to subject the left ventricle to pressure overload for short-term (1 to 2 days) or long-term (1 to 2 weeks) periods. Heart-to-body weight ratios and cell capacitance measurements were used to determine hypertrophy. Whole-cell patch clamp recordings of the predominant repolarization currents Ito,fast and IK,slow were used to assess electrical remodeling. Hearts or myocytes subjected to long-term load displayed significant hypertrophy, which was not evident in short-term load. However, short-term load induced significant reductions in Ito,fast and IK,slow. Incubation of these myocytes with the angiotensin II type 1 receptor inhibitor saralasin for 2 hours restored Ito,fast and IK,slow to control levels. The number of Ito.fast or IK,slow channels did not change with A2 or long-term load, however the hypertrophic increase in membrane area reduced the current densities for both channels. For Ito,fast but not IK,slow there was an additional reduction that was reversed by inhibition of angiotensin receptors. These results suggest increased load activates an endogenous renin angiotensin system that initially reduces Ito,fast and IK,slow prior to the onset of hypertrophic growth. However, there are functional interactions between electrical and anatomical remodeling. First, hypertrophy tends to reduce all current densities. Second, the hypertrophic program can modify signaling between the angiotensin receptor and target current. PMID:28464037

Experimental and Numerical Investigation on the Bearing and Failure Mechanism of Multiple Pillars Under Overburden

NASA Astrophysics Data System (ADS)

Zhou, Zilong; Chen, Lu; Zhao, Yuan; Zhao, Tongbin; Cai, Xin; Du, Xueming

2017-04-01

To reveal the mechanical response of a multi-pillar supporting system under external loads, compressive tests were carried out on single-pillar and double-pillar specimens. The digital speckle correlation method and acoustic emission technique were applied to record and analyse information of the deformation and failure processes. Numerical simulations with the software programme PFC2D were also conducted. In the compressive process of the double-pillar system, if both individual pillars have the same mechanical properties, each pillar deforms similarly and reaches the critical stable state almost simultaneously by sharing equal loads. If the two individual pillars have different mechanical properties, the pillar with higher elastic modulus or lower strength would be damaged and lose its bearing capacity firstly. The load would then be transferred to the other pillar under a load redistribution process. When the pillar with higher strength is strong enough, the load carried by the pillar system would increase again. However, the maximum bearing load of the double-pillar system is smaller than the sum of peak load of individual pillars. The study also indicates that the strength, elastic modulus, and load state of pillars all influence the supporting capacity of the pillar system. In underground space engineering, the appropriate choice of pillar dimensions and layout may play a great role in preventing the occurrence of cascading pillar failure.

Fruit load induces changes in global gene expression and in abscisic acid (ABA) and indole acetic acid (IAA) homeostasis in citrus buds.

PubMed

Shalom, Liron; Samuels, Sivan; Zur, Naftali; Shlizerman, Lyudmila; Doron-Faigenboim, Adi; Blumwald, Eduardo; Sadka, Avi

2014-07-01

Many fruit trees undergo cycles of heavy fruit load (ON-Crop) in one year, followed by low fruit load (OFF-Crop) the following year, a phenomenon known as alternate bearing (AB). The mechanism by which fruit load affects flowering induction during the following year (return bloom) is still unclear. Although not proven, it is commonly accepted that the fruit or an organ which senses fruit presence generates an inhibitory signal that moves into the bud and inhibits apical meristem transition. Indeed, fruit removal from ON-Crop trees (de-fruiting) induces return bloom. Identification of regulatory or metabolic processes modified in the bud in association with altered fruit load might shed light on the nature of the AB signalling process. The bud transcriptome of de-fruited citrus trees was compared with those of ON- and OFF-Crop trees. Fruit removal resulted in relatively rapid changes in global gene expression, including induction of photosynthetic genes and proteins. Altered regulatory mechanisms included abscisic acid (ABA) metabolism and auxin polar transport. Genes of ABA biosynthesis were induced; however, hormone analyses showed that the ABA level was reduced in OFF-Crop buds and in buds shortly following fruit removal. Additionally, genes associated with Ca(2+)-dependent auxin polar transport were remarkably induced in buds of OFF-Crop and de-fruited trees. Hormone analyses showed that auxin levels were reduced in these buds as compared with ON-Crop buds. In view of the auxin transport autoinhibition theory, the possibility that auxin distribution plays a role in determining bud fate is discussed. © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology.

Vascular capacitance and cardiac output in pacing-induced canine models of acute and chronic heart failure.

PubMed

Ogilvie, R I; Zborowska-Sluis, D

1995-11-01

The relationship between stressed and total blood volume, total vascular capacitance, central blood volume, cardiac output (CO), and pulmonary capillary wedge pressure (Ppcw) was investigated in pacing-induced acute and chronic heart failure. Acute heart failure was induced in anesthetized splenectomized dogs by a volume load (20 mL/kg over 10 min) during rapid right ventricular pacing at 250 beats/min (RRVP) for 60 min. Chronic heart failure was induced by continuous RRVP for 2-6 weeks (average 24 +/- 2 days). Total vascular compliance and capacitance were calculated from the mean circulatory filling pressure (Pmcf) during transient circulatory arrest after acetylcholine at three different circulating volumes. Stressed blood volume was calculated as a product of compliance and Pmcf, with the total blood volume measured by a dye dilution. Central blood volume (CBV) and CO were measured by thermodilution. Central (heart and lung) vascular capacitance was estimated from the plot of Ppcw against CBV. Acute volume loading without RRVP increased capacitance and CO, whereas after volume loading with RRVP, capacitance and CO were unaltered from baseline. Chronic RRVP reduced capacitance and CO. All interventions, volume +/- RRVP or chronic RRVP, increased stressed and central blood volumes and Ppcw. Acute or chronic RRVP reduced central vascular capacitance. Cardiac output was increased when stressed and unstressed blood volumes increased proportionately as during volume loading alone. When CO was reduced and Ppcw increased, as during chronic RRVP or acute RRVP plus a volume load, stressed blood volume was increased and unstressed blood volume was decreased. Thus, interventions that reduced CO and increased Ppcw also increased stressed and reduced unstressed blood volume and total vascular capacitance.

Innovative design of composite structures: Axisymmetric deformations of unsymmetrically laminated cylinders loaded in axial compression

NASA Technical Reports Server (NTRS)

Hyer, M. W.; Paraska, P. J.

1990-01-01

The study focuses on the axisymmetric deformation response of unsymmetrically laminate cylinders loaded in axial compression by known loads. A geometrically nonlinear analysis is used. Though buckling is not studied, the deformations can be considered to be the prebuckling response. Attention is directed at three 16 layer laminates: a (90 sub 8/0 sub 8) sub T; a (0 sub 8/90 sub 8) sub T and a (0/90) sub 4s. The symmetric laminate is used as a basis for comparison, while the two unsymmetric laminates were chosen because they have equal but opposite bending-stretching effects. Particular attention is given to the influence of the thermally-induced preloading deformations that accompany the cool-down of any unsymmetric laminate from the consolidation temperature. Simple support and clamped boundary conditions are considered. It is concluded that: (1) The radial deformations of an unsymmetric laminate are significantly larger than the radial deformations of a symmetric laminate, although for both symmetric and unsymmetric laminates the large deformations are confined to a boundary layer near the ends of the cylinder; (2) For this nonlinear problem the length of the boundary layer is a function of the applied load; (3) The sign of the radial deformations near the supported end of the cylinder depends strongly on the sense (sign) of the laminate asymmetry; (4) For unsymmetric laminates, ignoring the thermally-induced preloading deformations that accompany cool-down results in load-induced deformations that are under predicted; and (5) The support conditions strongly influence the response but the influence of the sense of asymmetry and the influence of the thermally-induced preloading deformations are independent of the support conditions.

Food load manipulation ability shapes flight morphology in females of central-place foraging Hymenoptera

PubMed Central

2013-01-01

Background Ecological constraints related to foraging are expected to affect the evolution of morphological traits relevant to food capture, manipulation and transport. Females of central-place foraging Hymenoptera vary in their food load manipulation ability. Bees and social wasps modulate the amount of food taken per foraging trip (in terms of e.g. number of pollen grains or parts of prey), while solitary wasps carry exclusively entire prey items. We hypothesized that the foraging constraints acting on females of the latter species, imposed by the upper limit to the load size they are able to transport in flight, should promote the evolution of a greater load-lifting capacity and manoeuvrability, specifically in terms of greater flight muscle to body mass ratio and lower wing loading. Results Our comparative study of 28 species confirms that, accounting for shared ancestry, female flight muscle ratio was significantly higher and wing loading lower in species taking entire prey compared to those that are able to modulate load size. Body mass had no effect on flight muscle ratio, though it strongly and negatively co-varied with wing loading. Across species, flight muscle ratio and wing loading were negatively correlated, suggesting coevolution of these traits. Conclusions Natural selection has led to the coevolution of resource load manipulation ability and morphological traits affecting flying ability with additional loads in females of central-place foraging Hymenoptera. Release from load-carrying constraints related to foraging, which took place with the evolution of food load manipulation ability, has selected against the maintenance of a powerful flight apparatus. This could be the case since investment in flight muscles may have to be traded against other life-history traits, such as reproductive investment. PMID:23805850

Dynamics of rain-induced pollutographs of solubles in sewers.

PubMed

Rutsch, M; Müller, I; Krebs, P

2005-01-01

When looking at acute receiving water impacts due to combined sewer overflows the characteristics of the background diurnal sewage flux variation may influence the peak loads from combined sewer overflows (CSO) and wastewater treatment plant (WWTP) effluent significantly. In this paper, effects on the dynamic compounds transported in the sewer, on CSO discharges and WWTP loading are evaluated by means of hydrodynamic simulations. The simulations are based on different scenarios for diurnal dry-weather flow variations induced by different infiltration rates.

Knee Joint Loading during Gait in Healthy Controls and Individuals with Knee Osteoarthritis

PubMed Central

Kumar, Deepak; Manal, Kurt T.; Rudolph, Katherine S.

2013-01-01

Objective People with knee osteoarthritis (OA) are thought to walk with high loads at the knee which are yet to be quantfied using modeling techniques that account for subject specific EMG patterns, kinematics and kinetics. The objective was to estimate medial and lateral loading for people with knee OA and controls using an approach that is sensitive to subject specific muscle activation patterns. Methods 16 OA and 12 control (C) subjects walked while kinematic, kinetic and EMG data were collected. Muscle forces were calculated using an EMG-Driven model and loading was calculated by balancing the external moments with internal muscle and contact forces Results OA subjects walked slower and had greater laxity, static and dynamic varus alignment, less flexion and greater knee adduction moment (KAM). Loading (normalized to body weight) was no different between the groups but OA subjects had greater absolute medial load than controls and maintained a greater %total load on the medial compartment. These patterns were associated with body mass, sagittal and frontal plane moments, static alignment and close to signficance for dynamic alignment. Lateral compartment unloading during mid-late stance was observed in 50% of OA subjects. Conclusions Loading for control subjects was similar to data from instrumented prostheses. Knee OA subjects had high medial contact loads in early stance and half of the OA cohort demonstared lateral compartment lift-off. Results suggest that interventions aimed at reducing body weight and dynamic malalignment might be effective in reducing medial compartment loading and establishing normal medio-lateral load sharing patterns. PMID:23182814

Wheel load cycle tag for rail : final report.

DOT National Transportation Integrated Search

2015-12-01

The Federal Railroad Administration (FRA) has determined that there is a research need to collect and analyze statistical usage : data to help ascertain the cumulative load-induced fatigue on rail track segments. The estimation of rail segment burden...

Knuckle-walking anteater: a convergence test of adaptation for purported knuckle-walking features of African Hominidae.

PubMed

Orr, Caley M

2005-11-01

Appeals to synapomorphic features of the wrist and hand in African apes, early hominins, and modern humans as evidence of knuckle-walking ancestry for the hominin lineage rely on accurate interpretations of those features as adaptations to knuckle-walking locomotion. Because Gorilla, Pan, and Homo share a relatively close common ancestor, the interpretation of such features is confounded somewhat by phylogeny. The study presented here examines the evolution of a similar locomotor regime in New World anteaters (order Xenarthra, family Myrmecophagidae) and uses the terrestrial giant anteater (Myrmecophaga tridactyla) as a convergence test of adaptation for purported knuckle-walking features of the Hominidae. During the stance phase of locomotion, Myrmecophaga transmits loads through flexed digits and a vertical manus, with hyperextension occurring at the metacarpophalangeal joints of the weight-bearing rays. This differs from the locomotion of smaller, arboreal anteaters of outgroup genera Tamandua and Cyclopes that employ extended wrist postures during above-branch quadrupedality. A number of features shared by Myrmecophaga and Pan and Gorilla facilitate load transmission or limit extension, thereby stabilizing the wrist and hand during knuckle-walking, and distinguish these taxa from their respective outgroups. These traits are a distally extended dorsal ridge of the distal radius, proximal expansion of the nonarticular surface of the dorsal capitate, a pronounced articular ridge on the dorsal aspects of the load-bearing metacarpal heads, and metacarpal heads that are wider dorsally than volarly. Only the proximal expansion of the nonarticular area of the dorsal capitate distinguishes knuckle-walkers from digitigrade cercopithecids, but features shared with digitigrade primates might be adaptive to the use of a vertical manus of some sort in the stance phase of terrestrial locomotion. The appearance of capitate nonarticular expansion and the dorsal ridge of the distal radius in the hominin lineage might be indicative of a knuckle-walking ancestry for bipedal hominins if interpreted within the biomechanical and phylogenetic context of hominid locomotor evolution. Copyright 2005 Wiley-Liss, Inc

The Effects of Warhead-Induced Damage on the Aeroelastic Characteristics of Lifting Surfaces. Volume I. Aeroelastic Effects.

DTIC Science & Technology

1980-07-01

Arnold. Some further insight into the problem is obtained here, however, when it is demonstrated that highly optimized structural designs may...aircraft of this type are normally designed to withstand loads up to 1.5 times the maximum limit load (load factor 8.0 to 8.67), the structure should...on the wing, for example, give rise to concentrated drag and chordwise loadings as does the recoil from firing wing mounted gun systems . The drag on

A comparison of queueing, cluster and distributed computing systems

NASA Technical Reports Server (NTRS)

Kaplan, Joseph A.; Nelson, Michael L.

1993-01-01

Using workstation clusters for distributed computing has become popular with the proliferation of inexpensive, powerful workstations. Workstation clusters offer both a cost effective alternative to batch processing and an easy entry into parallel computing. However, a number of workstations on a network does not constitute a cluster. Cluster management software is necessary to harness the collective computing power. A variety of cluster management and queuing systems are compared: Distributed Queueing Systems (DQS), Condor, Load Leveler, Load Balancer, Load Sharing Facility (LSF - formerly Utopia), Distributed Job Manager (DJM), Computing in Distributed Networked Environments (CODINE), and NQS/Exec. The systems differ in their design philosophy and implementation. Based on published reports on the different systems and conversations with the system's developers and vendors, a comparison of the systems are made on the integral issues of clustered computing.

Operational wave now- and forecast in the German Bight as a basis for the assessment of wave-induced hydrodynamic loads on coastal dikes

NASA Astrophysics Data System (ADS)

Dreier, Norman; Fröhle, Peter

2017-12-01

The knowledge of the wave-induced hydrodynamic loads on coastal dikes including their temporal and spatial resolution on the dike in combination with actual water levels is of crucial importance of any risk-based early warning system. As a basis for the assessment of the wave-induced hydrodynamic loads, an operational wave now- and forecast system is set up that consists of i) available field measurements from the federal and local authorities and ii) data from numerical simulation of waves in the German Bight using the SWAN wave model. In this study, results of the hindcast of deep water wave conditions during the winter storm on 5-6 December, 2013 (German name `Xaver') are shown and compared with available measurements. Moreover field measurements of wave run-up from the local authorities at a sea dike on the German North Sea Island of Pellworm are presented and compared against calculated wave run-up using the EurOtop (2016) approach.

Host-guest interaction induced supramolecular amphiphilic star architecture and uniform nanovesicle formation for anticancer drug delivery

NASA Astrophysics Data System (ADS)

Zhu, Jing-Ling; Liu, Kerh Li; Wen, Yuting; Song, Xia; Li, Jun

2016-01-01

A star polymer of poly[(R,S)-3-hydroxybutyrate] (PHB) with adamantyl end-terminals extended from an α-cyclodextrin (α-CD) core is designed. It subsequently self-assembles to form controllable and uniform nanovesicles induced by host-guest interactions between heptakis(2,6-di-O-methyl)-β-CD and the adamantyl ends. The nanovesicles are suitable for loading and intracellular delivery of the anticancer drug doxorubicin.A star polymer of poly[(R,S)-3-hydroxybutyrate] (PHB) with adamantyl end-terminals extended from an α-cyclodextrin (α-CD) core is designed. It subsequently self-assembles to form controllable and uniform nanovesicles induced by host-guest interactions between heptakis(2,6-di-O-methyl)-β-CD and the adamantyl ends. The nanovesicles are suitable for loading and intracellular delivery of the anticancer drug doxorubicin. Electronic supplementary information (ESI) available: Polymer synthesis, characterization, preparation of drug-loaded nanovesicles, intracellular drug release and cytotoxicity assays, TEM and DLS measurements. See DOI: 10.1039/c5nr06744h

Pilot Study for Definition of Track Component Load Environments

DOT National Transportation Integrated Search

1981-02-01

This report describes the results of an experimental and analytical effort to define the vehicle induced load environment in an at-grade, concrete tie/ballast transit track structure. The experiment was performed on the UMTA transit track oval at the...

Estimating Track Capacity Based on Rail Stresses and Metal Fatigue.

DOT National Transportation Integrated Search

2011-09-21

This paper describes a framework to evaluate the structural capacity of railroad track to train-induced loads. The framework is applied to estimate structural performance in terms of allowable limits for crosstie spacing. Evaluation of the load-carry...

Fundamentals of track lateral shift for high-speed rail applications

DOT National Transportation Integrated Search

1998-12-01

The fundamental mechanics of track lateral shift due to vehicle and thermally induced loads are defined, and an analytic approach is presented for the determination of "limit" loads and deflections on the track to prevent progressive lateral shift. T...

Development and characterization of morin hydrate loaded microemulsion for the management of Alzheimer's disease.

PubMed

Sharma, Dheeraj; Singh, Manpreet; Kumar, Punnet; Vikram, Vir; Mishra, Neeraj

2017-12-01

The aim of this study is to prepare and characterize intranasal delivery of morin hydrate loaded microemulsion for the management of Alzheimer's diseases. After intranasal delivery, brain and blood drug concentrations were found to be higher for optimized morin hydrate loaded microemulsion as compared to plain morin hydrate. Significant (P < 0.05) reduction in assessed pharmacodynamic parameters was observed after intranasal administration of morin hydrate loaded microemulsion as compared to sham control group. Daily chronic treatment with morin loaded microemulsion till the 21st day significantly increased the memory in wistar rats with STZ-induced dementia.

Evidence Report: Risk of Bone Fracture due to Spaceflight-Induced Changes to Bone

NASA Technical Reports Server (NTRS)

Sibonga, Jean D.; Evans, Harlan J.; Smith, Scott A.; Spector, Elisabeth R.; Yardley, Greg; Myer, Jerry

2017-01-01

Given that spaceflight may induce adverse changes in bone ultimate strength with respect to mechanical loads during and post-mission, there is a possibility a fracture may occur for activities otherwise unlikely to induce fracture prior to initiating spaceflight.

Activation of Wnt Signaling by Mechanical Loading Is Impaired in the Bone of Old Mice

PubMed Central

Holguin, Nilsson; Brodt, Michael D; Silva, Matthew J

2017-01-01

Aging diminishes bone formation engendered by mechanical loads, but the mechanism for this impairment remains unclear. Because Wnt signaling is required for optimal loading-induced bone formation, we hypothesized that aging impairs the load-induced activation of Wnt signaling. We analyzed dynamic histomorphometry of 5-month-old, 12-month-old, and 22-month-old C57Bl/6JN mice subjected to multiple days of tibial compression and corroborated an age-related decline in the periosteal loading response on day 5. Similarly, 1 day of loading increased periosteal and endocortical bone formation in young-adult (5-month-old) mice, but old (22-month-old) mice were unresponsive. These findings corroborated mRNA expression of genes related to bone formation and the Wnt pathway in tibias after loading. Multiple bouts (3 to 5 days) of loading upregulated bone formation–related genes, e.g., Osx and Col1a1, but older mice were significantly less responsive. Expression of Wnt negative regulators, Sost and Dkk1, was suppressed with a single day of loading in all mice, but suppression was sustained only in young-adult mice. Moreover, multiple days of loading repeatedly suppressed Sost and Dkk1 in young-adult, but not in old tibias. The age-dependent response to loading was further assessed by osteocyte staining for Sclerostin and LacZ in tibia of TOPGAL mice. After 1 day of loading, fewer osteocytes were Sclerostin-positive and, corroboratively, more osteocytes were LacZ-positive (Wnt active) in both 5-month-old and 12-month-old mice. However, although these changes were sustained after multiple days of loading in 5-month-old mice, they were not sustained in 12-month-old mice. Last, Wnt1 and Wnt7b were the most load-responsive of the 19 Wnt ligands. However, 4 hours after a single bout of loading, although their expression was upregulated threefold to 10-fold in young-adult mice, it was not altered in old mice. In conclusion, the reduced bone formation response of aged mice to loading may be due to failure to sustain Wnt activity with repeated loading. PMID:27357062

Composite load spectra for select space propulsion structural components

NASA Technical Reports Server (NTRS)

Newell, J. F.; Kurth, R. E.; Ho, H.

1991-01-01

The objective of this program is to develop generic load models with multiple levels of progressive sophistication to simulate the composite (combined) load spectra that are induced in space propulsion system components, representative of Space Shuttle Main Engines (SSME), such as transfer ducts, turbine blades, and liquid oxygen posts and system ducting. The first approach will consist of using state of the art probabilistic methods to describe the individual loading conditions and combinations of these loading conditions to synthesize the composite load spectra simulation. The second approach will consist of developing coupled models for composite load spectra simulation which combine the deterministic models for composite load dynamic, acoustic, high pressure, and high rotational speed, etc., load simulation using statistically varying coefficients. These coefficients will then be determined using advanced probabilistic simulation methods with and without strategically selected experimental data.

DPPP: Default Pre-Processing Pipeline

NASA Astrophysics Data System (ADS)

van Diepen, Ger; Dijkema, Tammo Jan

2018-04-01

DPPP (Default Pre-Processing Pipeline, also referred to as NDPPP) reads and writes radio-interferometric data in the form of Measurement Sets, mainly those that are created by the LOFAR telescope. It goes through visibilities in time order and contains standard operations like averaging, phase-shifting and flagging bad stations. Between the steps in a pipeline, the data is not written to disk, making this tool suitable for operations where I/O dominates. More advanced procedures such as gain calibration are also included. Other computing steps can be provided by loading a shared library; currently supported external steps are the AOFlagger (ascl:1010.017) and a bridge that enables loading python steps.

Axisymmetric deformations and stresses of unsymmetrically laminated composite cylinders in axial compression with thermally-induced preloading effects

NASA Technical Reports Server (NTRS)

Paraska, Peter J.

1993-01-01

This report documents an analytical study of the response of unsymmetrically laminated cylinders subjected to thermally-induced preloading effects and compressive axial load. Closed-form solutions are obtained for the displacements and intralaminar stresses and recursive relations for the interlaminar shear stress were obtained using the closed-form intralaminar stress solutions. For the cylinder geometries and stacking sequence examples analyzed, several important and as yet undocumented effects of including thermally-induced preloading in the analysis are observed. It should be noted that this work is easily extended to include uniform internal and/or external pressure loadings and the application of strain and stress failure theories.

Neuroprotective potential of sesamol and its loaded solid lipid nanoparticles in ICV-STZ-induced cognitive deficits: behavioral and biochemical evidence.

PubMed

Sachdeva, Anand Kamal; Misra, Shubham; Pal Kaur, Indu; Chopra, Kanwaljit

2015-01-15

Neuroinflammation is a prominent feature of Alzheimer disease (AD) and other chronic neurodegenerative disorders. Intracerebroventricular (ICV) streptozotocin (STZ) induced-cognitive impairment has been widely used as an experimental paradigm of Alzheimer׳s disease. Sesamol is a potent inhibitor of cytokine production as well as an antioxidant. The present study was designed to evaluate the effectiveness of sesamol in ICV-STZ-induced cognitive deficits in rats by incorporating it into solid lipid nanoparticles (SLNs). ICV-STZ administration produced significant cognitive deficits as assessed by both Morris water maze and elevated plus maze task which is accompanied by significantly enhanced nitrodative stress, altered acetylcholinesterase in rat brain along with significantly increased serum TNF-α levels. Chronic treatment with sesamol and sesamol loaded SLNs dose dependently restored cognitive deficits in ICV-STZ rats along with mitigation of nitrodative stress and cytokine release. Effectiveness of SLNs to deliver sesamol to the brain was shown by a significantly better alleviation of the oxidative stress parameters. Our findings demonstrate that loading of sesamol in SLNs is an effective strategy to mitigate ICV-STZ-induced neuronal dysfunction and memory deficits. Copyright © 2014 Elsevier B.V. All rights reserved.

Pain as social glue: shared pain increases cooperation.

PubMed

Bastian, Brock; Jetten, Jolanda; Ferris, Laura J

2014-11-01

Even though painful experiences are employed within social rituals across the world, little is known about the social effects of pain. We examined the possibility that painful experiences can promote cooperation within social groups. In Experiments 1 and 2, we induced pain by asking some participants to insert their hands in ice water and to perform leg squats. In Experiment 3, we induced pain by asking some participants to eat a hot chili pepper. Participants performed these tasks in small groups. We found evidence for a causal link: Sharing painful experiences with other people, compared with a no-pain control treatment, promoted trusting interpersonal relationships by increasing perceived bonding among strangers (Experiment 1) and increased cooperation in an economic game (Experiments 2 and 3). Our findings shed light on the social effects of pain, demonstrating that shared pain may be an important trigger for group formation. © The Author(s) 2014.

Industrial approach to piezoelectric damping of large fighter aircraft components

NASA Astrophysics Data System (ADS)

Simpson, John; Schweiger, Johannes

1998-06-01

Different concepts to damp structural vibrations of the vertical tail of fighter aircraft are reported. The various requirements for a vertical tail bias an integrated approach for the design. Several active vibrations suppression concepts had been investigated during the preparatory phase of a research program shared by Daimler-Benz Aerospace Military Aircraft (Dasa), Daimler-Benz Forschung (DBF) and Deutsche Forschungsandstalt fuer Luftund Raumfahrt (DLR). Now in the main phase of the programme, four concepts were finally chosen: two concepts with aerodynamic control surfaces and two concepts with piezoelectric components. One piezo concept approach will be described rigorously, the other concepts are briefly addressed. In the Dasa concept, thin surface piezo actuators are set out carefully to flatten the dynamic portion of the combined static and dynamic maximum bending moment loading case directly in the shell structure. The second piezo concept by DLR involves pre-loaded lead zirconate titanate (PZT)-block actuators at host structure fixtures. To this end a research apparatus was designed and built as a full scale simplified fin box with carbon fiber reinformed plastic skins and an aluminium stringer-rib substructure restrained by relevant aircraft fixtures. It constitutes a benchmark 3D-structural impedance. The engineering design incorporates 7kg of PZT surface actuators. The structural system then should be excited to more than 15mm tip displacement amplitude. This prepares the final step to total A/C integration. Typical analysis methods using cyclic thermal analogies adapted to induced load levels are compared. Commercial approaches leading onto basic state space model interpretation wrt. actuator sizing and positioning, structural integrity constraints, FE-validation and testing are described. Both piezoelectric strategies are aimed at straight open-loop performance related to concept weight penalty and input electric power. The required actuators, power and integration are then enhanced to specification standards. An adapted qualification program plan is used to improve analytical read across, specifications, manufacturing decisions, handling requirements. The next research goals are outlined.

An In Vivo Lapine Model for Impact-Induced Injury and Osteoarthritic Degeneration of Articular Cartilage

PubMed Central

Alexander, Peter G.; McCarron, Jesse A.; Levine, Matthew J.; Melvin, Gary M.; Murray, Patrick J.; Manner, Paul A.

2012-01-01

Objective: In this study, we applied a spring-loaded impactor to deliver traumatic forces to articular cartilage in vivo. Based on our recent finding that a 0.28-J impact induces maximal catabolic response in adult bovine articular cartilage in vitro using this device, we hypothesize that this impact will induce the formation of a focal osteoarthritic defect in vivo. Design: The femoral condyle of New Zealand White rabbits was exposed and one of the following procedures performed: 0.28 J impact, anterior cruciate ligament transection, articular surface grooving, or no joint or cartilage destruction (control). After 24 hours, 4 weeks, or 12 weeks (n = 3 for each time point), wounds were localized with India ink, and tissue samples were collected and characterized histomorphometrically with Safranin O/Fast green staining and Hoechst 33342 nuclear staining for cell vitality. Results: The spring-loaded device delivered reproducible impacts with the following characteristics: impact area of 1.39 ± 0.11 mm2, calculated load of 326 ± 47.3 MPa, time-to-peak of 0.32 ± 0.03 ms, and an estimated maximal displacement of 25.1% ± 4.5% at the tip apex. The impact resulted in immediate cartilage fissuring and cell loss in the surface and intermediate zones, and it induced the formation of a focal lesion at 12 weeks. The degeneration was defined and appeared more slowly than after anterior cruciate ligament transection, and more pronounced and characteristic than after grooving. Conclusion: A single traumatic 0.28 J impact delivered with this spring-loaded impactor induces focal cartilage degeneration characteristic of osteoarthritis. PMID:26069642

Topoisomerase I peptide-loaded dendritic cells induce autoantibody response as well as skin and lung fibrosis.

PubMed

Mehta, Heena; Goulet, Philippe-Olivier; Nguyen, Vinh; Pérez, Gemma; Koenig, Martial; Senécal, Jean-Luc; Sarfati, Marika

2016-12-01

DNA Topoisomerase I (TopoI) is a candidate autoantigen for diffuse cutaneous systemic sclerosis (dcSSc) associated with fatal lung disease. Dendritic cells (DCs) contribute to bleomycin-induced lung fibrosis. However, the possibility that TopoI-loaded DCs are involved in the initiation and/or perpetuation of dcSSc has not been explored. Here, we show that immunization with TopoI peptide-loaded DCs induces anti-TopoI autoantibody response and long-term fibrosis. Mice were repeatedly immunized with unpulsed DCs or DCs loaded with either TOPOIA or TOPOIB peptides, selected from different regions of TopoI. At week 12 after initial DC immunization, TOPOIA DCs but not TOPOIB DCs immunization induced mixed inflammation and fibrosis in lungs and skin. At a late time point (week 18), both TOPOIA DCs and TOPOIB DCs groups displayed increased alpha-smooth muscle actin expression in lungs and dermis along with skin fibrosis distal from the site of injection when compared with unpulsed DCs. Both TopoI peptide-DC-immunized groups developed IgG2a anti-TopoI autoantibody response. At week 10, signs of perivascular, peribronchial, and parenchymal pulmonary inflammation were already observed in the TOPOIA DCs group, together with transient elevation in bronchoalveolar lavage cell counts, IL-17A expression, and CXCL4 production, a biomarker of early human dcSSc. Collectively, TopoI peptide DCs induce progressive autoantibody response as well as development of protracted skin and lung dcSSc-like disease. Pronounced lung inflammation, transient IL-17A, and CXCL4 expression precede fibrosis development. Our immunization strategy, that uses self immune system and autoantigen, will help to further investigate the pathogenesis of this complex autoimmune disorder with unmet medical needs.

Returning vacationers face heavy reading loads. [Reports, surveys and projections on the national energy supply

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berg, T.F.

1991-10-01

This article reviews the various reports, surveys and projections on the national energy supply of the summer of 1991. Discussed are the natural gas supplies, competitive electric power production, reliability of independent power, public attitudes toward natural gas, the market share of natural gas, and projection of US energy supply and demand.

Embracing Tablet Technology in Military Construction

DTIC Science & Technology

2014-06-01

addition, 3D models can be loaded from websites, Google Docs, e-mail attachments (iPad only) or from iTunes (iPad only). Document Viewer iBlueprint—With...share and store project photos, log time card entries and more. The Procore app can be used on iPhones (OS 3.0 or later), iPads and iPod Touch. 27

Patient-Centered Culturally Sensitive Health Care: Trend or Major Thrust in Health Care Delivery?

ERIC Educational Resources Information Center

Killion, Cheryl M.

2007-01-01

In this reaction article to the Major Contribution, the merits and challenges of implementing patient-centered culturally sensitive health care, or cultural competence plus, are explicated. Three themes are addressed: separate but equal?, factoring in mental health, and sharing the load. The need to refine the conceptualization of the two…

Sharing the Load

ERIC Educational Resources Information Center

Reid, Karla Scoon

2005-01-01

For more than 10 years, the education community has watched the corporate ups and downs of Edison Schools Inc., the New York City company that has created controversy with its aim of making money from public schools. Long a target of those wary of such aims, the now privately held Edison made headlines with its four-year run as a public company,…

SLA Negotiation for VO Formation

NASA Astrophysics Data System (ADS)

Paurobally, Shamimabi

Resource management systems are changing from localized resources and services towards virtual organizations (VOs) sharing millions of heterogeneous resources across multiple organizations and domains. The virtual organizations and usage models include a variety of owners and consumers with different usage, access policies, cost models, varying loads, requirements and availability. The stakeholders have private utility functions that must be satisfied and possibly maximized.

Load variation effects on the pressure fluctuations exerted on a Kaplan turbine runner

NASA Astrophysics Data System (ADS)

Amiri, K.; Mulu, B.; Raisee, M.; Cervantes, M. J.

2014-03-01

Introduction of intermittent electricity production systems like wind power and solar systems to electricity market together with the consumption-based electricity production resulted in numerous start/stops, load variations and off-design operation of water turbines. The hydropower systems suffer from the varying loads exerted on the stationary and rotating parts of the turbines during load variations which they are not designed for. On the other hand, investigations on part load operation of single regulated turbines, i.e., Francis and propeller, proved the formation of rotating vortex rope (RVR) in the draft tube. The RVR induces oscillating flow both in plunging and rotating modes which results in oscillating force with two different frequencies on the runner blades, bearings and other rotating parts of the turbine. The purpose of this study is to investigate the effect of transient operations on the pressure fluctuations on the runner and mechanism of the RVR formation/mitigation. Draft tube and runner blades of the Porjus U9 model, a Kaplan turbine, were equipped with pressure sensors. The model was run in off-cam mode during different load variation conditions to check the runner performance under unsteady condition. The results showed that the transients between the best efficiency point and the high load happens in a smooth way while transitions to/from the part load, where rotating vortex rope (RVR) forms in the draft tube induces high level of fluctuations with two frequencies on the runner; plunging and rotating mode of the RVR.

Changes in speckle patterns induced by load application onto an optical fiber and its possible application for sensing purpose

NASA Astrophysics Data System (ADS)

Hasegawa, Makoto; Okumura, Jyun-ya; Hyuga, Akio

2015-08-01

Speckle patterns to be observed in an output light spot from an optical fiber are known to be changed due to external disturbances applied onto the optical fiber. In order to investigate possibilities of utilizing such changes in speckle patterns for sensing application, a certain load was applied onto a jacket-covered communication-grade multi-mode glass optical fiber through which laser beams emitted from a laser diode were propagating, and observed changes in speckle patterns in the output light spot from the optical fiber were investigated both as image data via a CCD camera and as an output voltage from a photovoltaic panel irradiated with the output light spot. The load was applied via a load application mechanism in which several ridges were provided onto opposite flat plates and a certain number of weights were placed there so that corrugated bending of the optical fiber was intentionally induced via load application due to the ridges. The obtained results showed that the number of speckles in the observed pattern in the output light spot as well as the output voltage from the photovoltaic panel irradiated with the output light spot showed decreases upon load application with relatively satisfactory repeatability. When the load was reduced, i.e., the weights were removed, the number of speckles then showed recovery. These results indicate there is a certain possibility of utilizing changes in speckle patterns for sensing of load application onto the optical fiber.

Heavy snow loads in Finnish forests respond regionally asymmetrically to projected climate change

DOE PAGES

Lehtonen, Ilari; Kamarainen, Matti; Gregow, Hilppa; ...

2016-10-17

This study examined the impacts of projected climate change on heavy snow loads on Finnish forests, where snow-induced forest damage occurs frequently. For snow-load calculations, we used daily data from five global climate models under representative concentration pathway (RCP) scenarios RCP4.5 and RCP8.5, statistically downscaled onto a high-resolution grid using a quantile-mapping method. Our results suggest that projected climate warming results in regionally asymmetric response on heavy snow loads in Finnish forests. In eastern and northern Finland, the annual maximum snow loads on tree crowns were projected to increase during the present century, as opposed to southern and western parts ofmore » the country. The change was rather similar both for heavy rime loads and wet snow loads, as well as for frozen snow loads. Only the heaviest dry snow loads were projected to decrease over almost the whole of Finland. Our results are aligned with previous snowfall projections, typically indicating increasing heavy snowfalls over the areas with mean temperature below -8 °C. In spite of some uncertainties related to our results, we conclude that the risk for snow-induced forest damage is likely to increase in the future in the eastern and northern parts of Finland, i.e. in the areas experiencing the coldest winters in the country. In conclusion, the increase is partly due to the increase in wet snow hazards but also due to more favourable conditions for rime accumulation in a future climate that is more humid but still cold enough.« less

Heavy snow loads in Finnish forests respond regionally asymmetrically to projected climate change

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lehtonen, Ilari; Kamarainen, Matti; Gregow, Hilppa

This study examined the impacts of projected climate change on heavy snow loads on Finnish forests, where snow-induced forest damage occurs frequently. For snow-load calculations, we used daily data from five global climate models under representative concentration pathway (RCP) scenarios RCP4.5 and RCP8.5, statistically downscaled onto a high-resolution grid using a quantile-mapping method. Our results suggest that projected climate warming results in regionally asymmetric response on heavy snow loads in Finnish forests. In eastern and northern Finland, the annual maximum snow loads on tree crowns were projected to increase during the present century, as opposed to southern and western parts ofmore » the country. The change was rather similar both for heavy rime loads and wet snow loads, as well as for frozen snow loads. Only the heaviest dry snow loads were projected to decrease over almost the whole of Finland. Our results are aligned with previous snowfall projections, typically indicating increasing heavy snowfalls over the areas with mean temperature below -8 °C. In spite of some uncertainties related to our results, we conclude that the risk for snow-induced forest damage is likely to increase in the future in the eastern and northern parts of Finland, i.e. in the areas experiencing the coldest winters in the country. In conclusion, the increase is partly due to the increase in wet snow hazards but also due to more favourable conditions for rime accumulation in a future climate that is more humid but still cold enough.« less

Distribution of stress on TMJ disc induced by use of chincup therapy: assessment by the finite element method.

PubMed

Calçada, Flávio Siqueira; Guimarães, Antônio Sérgio; Teixeira, Marcelo Lucchesi; Takamatsu, Flávio Atsushi

2017-01-01

To assess the distribution of stress produced on TMJ disc by chincup therapy, by means of the finite element method. a simplified three-dimensional TMJ disc model was developed by using Rhinoceros 3D software, and exported to ANSYS software. A 4.9N load was applied on the inferior surface of the model at inclinations of 30, 40, and 50 degrees to the mandibular plane (GoMe). ANSYS was used to analyze stress distribution on the TMJ disc for the different angulations, by means of finite element method. The results showed that the tensile and compressive stresses concentrations were higher on the inferior surface of the model. More presence of tensile stress was found in the middle-anterior region of the model and its location was not altered in the three directions of load application. There was more presence of compressive stress in the middle and mid-posterior regions, but when a 50o inclined load was applied, concentration in the middle region was prevalent. Tensile and compressive stresses intensities progressively diminished as the load was more vertically applied. stress induced by the chincup therapy is mainly located on the inferior surface of the model. Loads at greater angles to the mandibular plane produced distribution of stresses with lower intensity and a concentration of compressive stresses in the middle region. The simplified three-dimensional model proved useful for assessing the distribution of stresses on the TMJ disc induced by the chincup therapy.

Decreased inducibility of TNF expression in lipid-loaded macrophages

PubMed Central

Ares, Mikko PS; Stollenwerk, Maria; Olsson, Anneli; Kallin, Bengt; Jovinge, Stefan; Nilsson, Jan

2002-01-01

Background Inflammation and immune responses are considered to be very important in the pathogenesis of atherosclerosis. Lipid accumulation in macrophages of the arterial intima is a characteristic feature of atherosclerosis which can influence the inflammatory potential of macrophages. We studied the effects of lipid loading on the regulation of TNF expression in human monocyte-derived macrophages. Results In macrophages incubated with acetylated low density lipoprotein (ac-LDL) for 2 days, mRNA expression of TNF in cells stimulated with TNF decreased by 75%. In cell cultures stimulated over night with IL-1β, lipid loading decreased secretion of TNF into culture medium by 48%. These results suggest that lipid accumulation in macrophages makes them less responsive to inflammatory stimuli. Decreased basal activity and inducibility of transcription factor AP-1 was observed in lipid-loaded cells, suggesting a mechanism for the suppression of cytokine expression. NF-κB binding activity and inducibility were only marginally affected by ac-LDL. LDL and ac-LDL did not activate PPARγ. In contrast, oxidized LDL stimulated AP-1 and PPARγ but inhibited NF-κB, indicating that the effects of lipid loading with ac-LDL were not due to oxidation of lipids. Conclusions Accumulation of lipid, mainly cholesterol, results in down-regulation of TNF expression in macrophages. Since monocytes are known to be activated by cell adhesion, these results suggest that foam cells in atherosclerotic plaques may contribute less potently to an inflammatory reaction than newly arrived monocytes/macrophages. PMID:12366867

Prediction of load threshold of fibre-reinforced laminated composite panels subjected to low velocity drop-weight impact using efficient data filtering techniques

NASA Astrophysics Data System (ADS)

Farooq, Umar; Myler, Peter

This work is concerned with physical testing of carbon fibrous laminated composite panels with low velocity drop-weight impacts from flat and round nose impactors. Eight, sixteen, and twenty-four ply panels were considered. Non-destructive damage inspections of tested specimens were conducted to approximate impact-induced damage. Recorded data were correlated to load-time, load-deflection, and energy-time history plots to interpret impact induced damage. Data filtering techniques were also applied to the noisy data that unavoidably generate due to limitations of testing and logging systems. Built-in, statistical, and numerical filters effectively predicted load thresholds for eight and sixteen ply laminates. However, flat nose impact of twenty-four ply laminates produced clipped data that can only be de-noised involving oscillatory algorithms. Data filtering and extrapolation of such data have received rare attention in the literature that needs to be investigated. The present work demonstrated filtering and extrapolation of the clipped data using Fast Fourier Convolution algorithm to predict load thresholds. Selected results were compared to the damage zones identified with C-scan and acceptable agreements have been observed. Based on the results it is proposed that use of advanced data filtering and analysis methods to data collected by the available resources has effectively enhanced data interpretations without resorting to additional resources. The methodology could be useful for efficient and reliable data analysis and impact-induced damage prediction of similar cases' data.

Intra-storm variability in microbial partitioning and microbial loading rates.

PubMed

Krometis, Leigh-Anne H; Characklis, Gregory W; Simmons, Otto D; Dilts, Mackenzie J; Likirdopulos, Christina A; Sobsey, Mark D

2007-01-01

Association with particles in the water column can have a significant impact on microbial fate and transport. This study analyzed multiple stormwater samples taken throughout the duration of three separate storms (at two different sites) to evaluate the fraction of microbes partitioning to denser "settleable" particles and to examine how partitioning behavior varied over the course of a storm. Intra-storm sampling also allowed for estimates of microbial loading rates (both total and particle-associated) and cumulative storm-induced microbial load. Five different indicator organisms were examined, with the fraction of microbes associated with settleable particles assessed via a calibrated centrifugation method. Partitioning behavior varied across microorganism type, with an average of 40% of fecal coliforms, Escherichia coli, and enterococci associating with settleable particles, compared to approximately 65% of Clostridium perfringens spores and only 13% of total coliphage. Partitioning remained fairly constant for each type of organism throughout storm events. Nonetheless, higher concentrations of both settleable particles and microbes entering the water column soon after the onset of a storm led to higher loading rates of settleable microbes in the storm's earliest stages, a trend that could have important implications for the design of stormwater management structures (e.g., detention basins). Estimates of cumulative storm-induced microbial loading suggested that one day's worth of storm loading can be the equivalent of months, or even years, of dry-weather loading.

Cross-modal attention influences auditory contrast sensitivity: Decreasing visual load improves auditory thresholds for amplitude- and frequency-modulated sounds.

PubMed

Ciaramitaro, Vivian M; Chow, Hiu Mei; Eglington, Luke G

2017-03-01

We used a cross-modal dual task to examine how changing visual-task demands influenced auditory processing, namely auditory thresholds for amplitude- and frequency-modulated sounds. Observers had to attend to two consecutive intervals of sounds and report which interval contained the auditory stimulus that was modulated in amplitude (Experiment 1) or frequency (Experiment 2). During auditory-stimulus presentation, observers simultaneously attended to a rapid sequential visual presentation-two consecutive intervals of streams of visual letters-and had to report which interval contained a particular color (low load, demanding less attentional resources) or, in separate blocks of trials, which interval contained more of a target letter (high load, demanding more attentional resources). We hypothesized that if attention is a shared resource across vision and audition, an easier visual task should free up more attentional resources for auditory processing on an unrelated task, hence improving auditory thresholds. Auditory detection thresholds were lower-that is, auditory sensitivity was improved-for both amplitude- and frequency-modulated sounds when observers engaged in a less demanding (compared to a more demanding) visual task. In accord with previous work, our findings suggest that visual-task demands can influence the processing of auditory information on an unrelated concurrent task, providing support for shared attentional resources. More importantly, our results suggest that attending to information in a different modality, cross-modal attention, can influence basic auditory contrast sensitivity functions, highlighting potential similarities between basic mechanisms for visual and auditory attention.

Common neural substrates for visual working memory and attention.

PubMed

Mayer, Jutta S; Bittner, Robert A; Nikolić, Danko; Bledowski, Christoph; Goebel, Rainer; Linden, David E J

2007-06-01

Humans are severely limited in their ability to memorize visual information over short periods of time. Selective attention has been implicated as a limiting factor. Here we used functional magnetic resonance imaging to test the hypothesis that this limitation is due to common neural resources shared by visual working memory (WM) and selective attention. We combined visual search and delayed discrimination of complex objects and independently modulated the demands on selective attention and WM encoding. Participants were presented with a search array and performed easy or difficult visual search in order to encode one or three complex objects into visual WM. Overlapping activation for attention-demanding visual search and WM encoding was observed in distributed posterior and frontal regions. In the right prefrontal cortex and bilateral insula blood oxygen-level-dependent activation additively increased with increased WM load and attentional demand. Conversely, several visual, parietal and premotor areas showed overlapping activation for the two task components and were severely reduced in their WM load response under the condition with high attentional demand. Regions in the left prefrontal cortex were selectively responsive to WM load. Areas selectively responsive to high attentional demand were found within the right prefrontal and bilateral occipital cortex. These results indicate that encoding into visual WM and visual selective attention require to a high degree access to common neural resources. We propose that competition for resources shared by visual attention and WM encoding can limit processing capabilities in distributed posterior brain regions.

Muscle activity during leg strengthening exercise using free weights and elastic resistance: effects of ballistic vs controlled contractions.

PubMed

Jakobsen, Markus Due; Sundstrup, Emil; Andersen, Christoffer H; Aagaard, Per; Andersen, Lars L

2013-02-01

The present study's aim was to evaluate muscle activity during leg exercises using elastic vs. isoinertial resistance at different exertion and loading levels, respectively. Twenty-four women and eighteen men aged 26-67 years volunteered to participate in the experiment. Electromyographic (EMG) activity was recorded in nine muscles during a standardized forward lunge movement performed with dumbbells and elastic bands during (1) ballistic vs. controlled exertion, and (2) at low, medium and high loads (33%, 66% and 100% of 10 RM, respectively). The recorded EMG signals were normalized to MVC EMG. Knee joint angle was measured using electronic inclinometers. The following results were obtained. Loading intensity affected EMG amplitude in the order: low

Comparison of three methods of calculating strain in the mouse ulna in exogenous loading studies.

PubMed

Norman, Stephanie C; Wagner, David W; Beaupre, Gary S; Castillo, Alesha B

2015-01-02

Axial compression of mouse limbs is commonly used to induce bone formation in a controlled, non-invasive manner. Determination of peak strains caused by loading is central to interpreting results. Load-strain calibration is typically performed using uniaxial strain gauges attached to the diaphyseal, periosteal surface of a small number of sacrificed animals. Strain is measured as the limb is loaded to a range of physiological loads known to be anabolic to bone. The load-strain relationship determined by this subgroup is then extrapolated to a larger group of experimental mice. This method of strain calculation requires the challenging process of strain gauging very small bones which is subject to variability in placement of the strain gauge. We previously developed a method to estimate animal-specific periosteal strain during axial ulnar loading using an image-based computational approach that does not require strain gauges. The purpose of this study was to compare the relationship between load-induced bone formation rates and periosteal strain at ulnar midshaft using three different methods to estimate strain: (A) Nominal strain values based solely on load-strain calibration; (B) Strains calculated from load-strain calibration, but scaled for differences in mid-shaft cross-sectional geometry among animals; and (C) An alternative image-based computational method for calculating strains based on beam theory and animal-specific bone geometry. Our results show that the alternative method (C) provides comparable correlation between strain and bone formation rates in the mouse ulna relative to the strain gauge-dependent methods (A and B), while avoiding the need to use strain gauges. Published by Elsevier Ltd.

Three-dimensional nonlinear responses to impact loads on free-span pipeline: Torsional coupling and load steps

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chung, J.S.; Huttelmaier, H.P.; Cheng, B.R.

1995-12-31

For a heavy object falling on a free-span pipeline, this study assesses three-dimensional (3-D) pipe-span responses with the torsional ({theta}x-) coupling of a pipeline through the biaxial (y) bending responses. The static pipe-span equilibrium is achieved with its self-weight and buoyancy and the external torsional moment induced by the cross-flow (y-directional) current on the sagged pipe span. Load steps taken for 2 different sequences of applying static loads induced different pipe deformations, and the pipe twists in entirely different pattern. The two types of impact loads are applied in the vertical (z-) direction to excite the pipe span in itsmore » static equilibrium: (1) triangular impulse loading and (2) ramp loading. Boundary condition of the span supports is ``fixed-fixed`` at both ends in both displacement and rotation. 3-D coupled axial (x-), bending (y- and z-) and torsional ({theta}x-) responses, both state and dynamic, to the z-directional impact loadings, are modeled and analyzed by a nonlinear FEM method for a 16-in pipeline. The 3-D responses are compared with 2-D responses. The comparison shows significant torsional vibrations caused by the cross-flow current, especially for longer spans. The torsional ({theta}x-) coupling is very sensitive to the time-step size in achieving numerical stability and accuracy, particularly for the ramp loading and for a shorter span. For very large impact loads, the response frequencies differ from the fundamental frequencies of the span, exhibiting beatings and strong bending-to-axial and to-twist couplings. Also, the eigenvalues for the linear system are not necessarily the resonance frequencies for these nonlinear coupled responses.« less

Meal and beta-alanine coingestion enhances muscle carnosine loading.

PubMed

Stegen, Sanne; Blancquaert, Laura; Everaert, Inge; Bex, Tine; Taes, Youri; Calders, Patrick; Achten, Eric; Derave, Wim

2013-08-01

Beta-alanine (BA) is a popular ergogenic supplement because it can induce muscle carnosine loading. We hypothesize that, by analogy with creatine supplementation, 1) an inverse relationship between urinary excretion and muscle loading is present, and 2) the latter is stimulated by carbohydrate- and protein-induced insulin action. In study A, the effect of a 5-wk slow-release BA (SRBA) supplementation (4.8 g · d(-1)) on whole body BA retention was determined in seven men. We further determined whether the coingestion of carbohydrates and proteins with SRBA would improve retention. In study B (34 subjects), we explored the effect of meal timing on muscle carnosine loading (3.2 g · d(-1) during 6-7 wk). One group received pure BA (PBA) in between the meals; the other received PBA at the start of the meals, to explore the effect of meal-induced insulin release. Further, we compared with a third group receiving SRBA at the start of the meals. Orally ingested SRBA has a very high whole body retention (97%-98%) that is not declining throughout the 5-wk supplementation period, nor is it influenced by the coingestion of macronutrients. Thus, a very small portion (1%-2%) is lost through urinary excretion, and equally only a small portion is incorporated into muscle carnosine (≈ 3%), indicating that most ingested BA is metabolized (possibly through oxidation). Second, in soleus muscles, the efficiency of carnosine loading is significantly higher when PBA is coingested with a meal (+64%) compared with in between the meals (+41%), suggesting that insulin stimulates muscle carnosine loading. Finally, the chronic supplementation of SRBA versus PBA seems equally effective.

Cell death induced by the application of alternating magnetic fields to nanoparticle-loaded dendritic cells.

PubMed

Marcos-Campos, I; Asín, L; Torres, T E; Marquina, C; Tres, A; Ibarra, M R; Goya, G F

2011-05-20

In this work, the capability of primary, monocyte-derived dendritic cells (DCs) to uptake iron oxide magnetic nanoparticles (MNPs) is assessed and a strategy to induce selective cell death in these MNP-loaded DCs using external alternating magnetic fields (AMFs) is reported. No significant decrease in the cell viability of MNP-loaded DCs, compared to the control samples, was observed after five days of culture. The number of MNPs incorporated into the cytoplasm was measured by magnetometry, which confirmed that 1-5 pg of the particles were uploaded per cell. The intracellular distribution of these MNPs, assessed by transmission electron microscopy, was found to be primarily inside the endosomic structures. These cells were then subjected to an AMF for 30 min and the viability of the blank DCs (i.e. without MNPs), which were used as control samples, remained essentially unaffected. However, a remarkable decrease of viability from approximately 90% to 2-5% of DCs previously loaded with MNPs was observed after the same 30 min exposure to an AMF. The same results were obtained using MNPs having either positive (NH(2)(+)) or negative (COOH(-)) surface functional groups. In spite of the massive cell death induced by application of AMF to MNP-loaded DCs, the number of incorporated magnetic particles did not raise the temperature of the cell culture. Clear morphological changes at the cell structure after magnetic field application were observed using scanning electron microscopy. Therefore, local damage produced by the MNPs could be the main mechanism for the selective cell death of MNP-loaded DCs under an AMF. Based on the ability of these cells to evade the reticuloendothelial system, these complexes combined with an AMF should be considered as a potentially powerful tool for tumour therapy.

Sodium chloride promotes tissue inflammation via osmotic stimuli in subtotal-nephrectomized mice.

PubMed

Sakata, Fumiko; Ito, Yasuhiko; Mizuno, Masashi; Sawai, Akiho; Suzuki, Yasuhiro; Tomita, Takako; Tawada, Mitsuhiro; Tanaka, Akio; Hirayama, Akiyoshi; Sagara, Akihiro; Wada, Takashi; Maruyama, Shoichi; Soga, Tomoyoshi; Matsuo, Seiichi; Imai, Enyu; Takei, Yoshifumi

2017-04-01

Chronic inflammation, which is often associated with high all-cause and cardiovascular mortality, is prevalent in patients with renal failure; however, the precise mechanisms remain unclear. High-salt intake was reported to induce lymphangiogenesis and autoimmune diseases via osmotic stimuli with accumulation of sodium or chloride. In addition, sodium was recently reported to be stored in the extremities of dialysis patients. We studied the effects and mechanisms of high salt loading on tissue and systemic inflammation in subtotal-nephrectomized mice (5/6Nx) and in cultured cells. Macrophage infiltration in the peritoneal wall (P<0.001), heart (P<0.05) and para-aortic tissues (P<0.001) was significantly higher in 5/6Nx with salt loading (5/6Nx/NaCl) than in 5/6Nx without salt loading (5/6Nx/Water); however, there were no significant differences in blood pressure and renal function between the groups. Tissue interleukin-6, monocyte chemotactic protein-1 (MCP-1), serum- and glucocorticoid-inducible kinase 1 (Sgk1) and tonicity-responsive enhancer binding protein (TonEBP) mRNA were significantly elevated in the peritoneal wall and heart with 5/6Nx/NaCl when compared with 5/6Nx/Water. Sodium was stored in the abdominal wall, exerting high-osmotic conditions. Reversal of salt loading reduced macrophage infiltration associated with decreased TonEBP in 5/6Nx/NaCl. Macrophage infiltration associated with fibrosis induced by salt loading was decreased in the 5/6Nx/NaCl/CC chemokine receptor 2 (CCR2, receptor of MCP-1)-deficient mice when compared with 5/6Nx/NaCl/Wild mice, suggesting that CCR2 is required for macrophage infiltration in 5/6Nx with NaCl loading. In cultured mesothelial cells and cardiomyocytes, culture media with high NaCl concentration induced MCP-1, Sgk1 and TonEBP mRNA, all of which were suppressed by TonEBP siRNA, indicating that both MCP-1 and Sgk1 are downstream of TonEBP. Our study indicates that high NaCl intake induces MCP-1 expression leading to macrophage infiltration via the TonEBP-MCP-1 pathway in 5/6Nx/NaCl mice, and that TonEBP has a central role in inflammation in patients with renal failure taking high salt.

Hypertrophic gene expression induced by chronic stretch of excised mouse heart muscle.

PubMed

Raskin, Anna M; Hoshijima, Masahiko; Swanson, Eric; McCulloch, Andrew D; Omens, Jeffrey H

2009-09-01

Altered mechanical stress and strain in cardiac myocytes induce modifications in gene expression that affects cardiac remodeling and myocyte contractile function. To study the mechanisms of mechanotransduction in cardiomyocytes, probing alterations in mechanics and gene expression has been an effective strategy. However, previous studies are self-limited due to the general use of isolated neonatal rodent myocytes or intact animals. The main goal of this study was to develop a novel tissue culture chamber system for mouse myocardium that facilitates loading of cardiac tissue, while measuring tissue stress and deformation within a physiological environment. Intact mouse right ventricular papillary muscles were cultured in controlled conditions with superfusate at 95% O2/ 5% CO2, and 34 degrees C, such that cell to extracellular matrix adhesions as well as cell to cell adhesions were undisturbed and both passive and active mechanical properties were maintained without significant changes. The system was able to measure the induction of hypertrophic markers (BNP, ANP) in tissue after 2 hrs and 5 hrs of stretch. ANP induction was highly correlated with the diastolic load of the muscle but not with developed systolic load. Load induced ANP expression was blunted in muscles from muscle-LIM protein knockout mice, in which defective mechanotransduction pathways have been predicted.

Supplementation with a Polyphenol-Rich Extract, PerfLoad®, Improves Physical Performance during High-Intensity Exercise: A Randomized, Double Blind, Crossover Trial

PubMed Central

Cases, Julien; Romain, Cindy; Marín-Pagán, Cristian; Chung, Linda H.; Rubio-Pérez, José Miguel; Laurent, Caroline; Gaillet, Sylvie; Prost-Camus, Emmanuelle; Prost, Michel; Alcaraz, Pedro E.

2017-01-01

Workout capacity is energy-production driven. To produce peak metabolic power outputs, the organism predominantly relies more on anaerobic metabolism, but this undoubtedly has a negative and limiting impact on muscle function and performance. The aim of the study was to evaluate if an innovative polyphenol-based food supplement, PerfLoad®, was able to improve metabolic homeostasis and physical performance during high-intensity exercises under anaerobic conditions. The effect of a supplementation has been investigated on fifteen recreationally-active male athletes during a randomized, double-blind and crossover clinical investigation. The Wingate test, an inducer of an unbalanced metabolism associated to oxidative stress, was used to assess maximum anaerobic power during a high-intensity exercise on a cycle ergometer. Supplementation with PerfLoad® correlated with a significant increase in total power output (5%), maximal peak power output (3.7%), and average power developed (5%), without inducing more fatigue or greater heart rate. Instead, oxidative homeostasis was stabilized in supplemented subjects. Such results demonstrated that PerfLoad® is a natural and efficient solution capable of, similarly to training benefits, helping athletes to improve their physical performance, while balancing their metabolism and reducing exercise-induced oxidative stress. PMID:28441760

Methotrexate diethyl ester-loaded lipid-core nanocapsules in aqueous solution increased antineoplastic effects in resistant breast cancer cell line.

PubMed

Yurgel, Virginia C; Oliveira, Catiuscia P; Begnini, Karine R; Schultze, Eduarda; Thurow, Helena S; Leon, Priscila M M; Dellagostin, Odir A; Campos, Vinicius F; Beck, Ruy C R; Guterres, Silvia S; Collares, Tiago; Pohlmann, Adriana R; Seixas, Fabiana K

2014-01-01

Breast cancer is the most frequent cancer affecting women. Methotrexate (MTX) is an antimetabolic drug that remains important in the treatment of breast cancer. Its efficacy is compromised by resistance in cancer cells that occurs through a variety of mechanisms. This study evaluated apoptotic cell death and cell cycle arrest induced by an MTX derivative (MTX diethyl ester [MTX(OEt)2]) and MTX(OEt)2-loaded lipid-core nanocapsules in two MTX-resistant breast adenocarcinoma cell lines, MCF-7 and MDA-MB-231. The formulations prepared presented adequate granulometric profile. The treatment responses were evaluated through flow cytometry. Relying on the mechanism of resistance, we observed different responses between cell lines. For MCF-7 cells, MTX(OEt)2 solution and MTX(OEt)2-loaded lipid-core nanocapsules presented significantly higher apoptotic rates than untreated cells and cells incubated with unloaded lipid-core nanocapsules. For MDA-MB-231 cells, MTX(OEt)2-loaded lipid-core nanocapsules were significantly more efficient in inducing apoptosis than the solution of the free drug. S-phase cell cycle arrest was induced only by MTX(OEt)2 solution. The drug nanoencapsulation improved apoptosis induction for the cell line that presents MTX resistance by lack of transport receptors.

Methotrexate diethyl ester-loaded lipid-core nanocapsules in aqueous solution increased antineoplastic effects in resistant breast cancer cell line

PubMed Central

Yurgel, Virginia C; Oliveira, Catiuscia P; Begnini, Karine R; Schultze, Eduarda; Thurow, Helena S; Leon, Priscila MM; Dellagostin, Odir A; Campos, Vinicius F; Beck, Ruy CR; Guterres, Silvia S; Collares, Tiago; Pohlmann, Adriana R; Seixas, Fabiana K

2014-01-01

Breast cancer is the most frequent cancer affecting women. Methotrexate (MTX) is an antimetabolic drug that remains important in the treatment of breast cancer. Its efficacy is compromised by resistance in cancer cells that occurs through a variety of mechanisms. This study evaluated apoptotic cell death and cell cycle arrest induced by an MTX derivative (MTX diethyl ester [MTX(OEt)2]) and MTX(OEt)2-loaded lipid-core nanocapsules in two MTX-resistant breast adenocarcinoma cell lines, MCF-7 and MDA-MB-231. The formulations prepared presented adequate granulometric profile. The treatment responses were evaluated through flow cytometry. Relying on the mechanism of resistance, we observed different responses between cell lines. For MCF-7 cells, MTX(OEt)2 solution and MTX(OEt)2-loaded lipid-core nanocapsules presented significantly higher apoptotic rates than untreated cells and cells incubated with unloaded lipid-core nanocapsules. For MDA-MB-231 cells, MTX(OEt)2-loaded lipid-core nanocapsules were significantly more efficient in inducing apoptosis than the solution of the free drug. S-phase cell cycle arrest was induced only by MTX(OEt)2 solution. The drug nanoencapsulation improved apoptosis induction for the cell line that presents MTX resistance by lack of transport receptors. PMID:24741306

A Flexible Domain-Domain Hinge Promotes an Induced-fit Dominant Mechanism for the Loading of Guide-DNA into Argonaute Protein in Thermus thermophilus.

PubMed

Zhu, Lizhe; Jiang, Hanlun; Sheong, Fu Kit; Cui, Xuefeng; Gao, Xin; Wang, Yanli; Huang, Xuhui

2016-03-17

Argonaute proteins (Ago) are core components of the RNA Induced Silencing Complex (RISC) that load and utilize small guide nucleic acids to silence mRNAs or cleave foreign DNAs. Despite the essential role of Ago in gene regulation and defense against virus, the molecular mechanism of guide-strand loading into Ago remains unclear. We explore such a mechanism in the bacterium Thermus thermophilus Ago (TtAgo), via a computational approach combining molecular dynamics, bias-exchange metadynamics, and protein-DNA docking. We show that apo TtAgo adopts multiple closed states that are unable to accommodate guide-DNA. Conformations able to accommodate the guide are beyond the reach of thermal fluctuations from the closed states. These results suggest an induced-fit dominant mechanism for guide-strand loading in TtAgo, drastically different from the two-step mechanism for human Ago 2 (hAgo2) identified in our previous study. Such a difference between TtAgo and hAgo2 is found to mainly originate from the distinct rigidity of their L1-PAZ hinge. Further comparison among known Ago structures from various species indicates that the L1-PAZ hinge may be flexible in general for prokaryotic Ago's but rigid for eukaryotic Ago's.

Analysis of resonance mechanism and conditions of train bridge system

NASA Astrophysics Data System (ADS)

Xia, H.; Zhang, N.; Guo, W. W.

2006-11-01

In this paper, the resonance mechanism and conditions of train-bridge system are investigated through theoretical derivations, numerical simulations and experimental data analyses. The resonant responses of the bridge induced by moving trains are classified into three types according to different resonance mechanisms: the first is related to the periodical actions of moving load series of the vertical weights, lateral centrifugal and wind forces of vehicles; the second is induced by the loading rate of moving load series of vehicles; the third is owing to the periodically loading of the swing forces of the train vehicles excited by track irregularities and wheel hunting movements. The vehicle resonance is induced by the periodical action of regular arrangement of bridge spans and their deflections. The resonant conditions are proposed and the corresponding resonant train speeds are determined. The application scopes of resonance conditions are discussed. The resonance of the train-bridge system is affected by the span, total length, lateral and vertical stiffness of the bridge, the compositions of the train, and the axle arrangements and natural frequencies of the vehicles. The resonant train speeds for some bridges are estimated and are compared with the critical train speeds obtained from the dynamic simulation of train-bridge interaction model or from the field measurements.

Green's function and Bloch theory for the analysis of the dynamic response of a periodically supported beam to a moving load

NASA Astrophysics Data System (ADS)

Lassoued, R.; Lecheheb, M.; Bonnet, G.

2012-08-01

This paper describes an analytical method for the wave field induced by a moving load on a periodically supported beam. The Green's function for an Euler beam without support is evaluated by using the direct integration. Afterwards, it introduces the supports into the model established by using the superposition principle which states that the response from all the sleeper points and from the external point force add up linearly to give a total response. The periodicity of the supports is described by Bloch's theorem. The homogeneous system thus obtained represents a linear differential equation which governs rail response. It is initially solved in the homogeneous case, and it admits a no null solution if its determinant is null, this permits the establishment the dispersion equation to Bloch waves and wave bands. The Bloch waves and dispersion curves contain all the physics of the dynamic problem and the wave field induced by a dynamic load applied to the system is finally obtained by decomposition into Bloch waves, similarly to the usual decomposition into dynamic modes on a finite structure. The method is applied to obtain the field induced by a load moving at constant velocity on a thin beam supported by periodic elastic supports.

Global strength assessment in oblique waves of a large gas carrier ship, based on a non-linear iterative method

NASA Astrophysics Data System (ADS)

Domnisoru, L.; Modiga, A.; Gasparotti, C.

2016-08-01

At the ship's design, the first step of the hull structural assessment is based on the longitudinal strength analysis, with head wave equivalent loads by the ships' classification societies’ rules. This paper presents an enhancement of the longitudinal strength analysis, considering the general case of the oblique quasi-static equivalent waves, based on the own non-linear iterative procedure and in-house program. The numerical approach is developed for the mono-hull ships, without restrictions on 3D-hull offset lines non-linearities, and involves three interlinked iterative cycles on floating, pitch and roll trim equilibrium conditions. Besides the ship-wave equilibrium parameters, the ship's girder wave induced loads are obtained. As numerical study case we have considered a large LPG liquefied petroleum gas carrier. The numerical results of the large LPG are compared with the statistical design values from several ships' classification societies’ rules. This study makes possible to obtain the oblique wave conditions that are inducing the maximum loads into the large LPG ship's girder. The numerical results of this study are pointing out that the non-linear iterative approach is necessary for the computation of the extreme loads induced by the oblique waves, ensuring better accuracy of the large LPG ship's longitudinal strength assessment.

The role of indoleamine 2,3-dioxygenase in LP-BPM5 murine retroviral disease progression.

PubMed

O'Connor, Megan A; Green, William R

2013-05-17

Indoleamine 2,3-dioxygenase (IDO) is an immunomodulatory intracellular enzyme involved in tryptophan degradation. IDO is induced during cancer and microbial infections by cytokines, ligation of co-stimulatory molecules and/or activation of pattern recognition receptors, ultimately leading to modulation of the immune response. LP-BM5 murine retroviral infection induces murine AIDS (MAIDS), which is characterized by profound and broad immunosuppression of T- and B-cell responses. Our lab has previously described multiple mechanisms regulating the development of immunodeficiency of LP-BM5-induced disease, including Programmed Death 1 (PD-1), IL-10, and T-regulatory (Treg) cells. Immunosuppressive roles of IDO have been demonstrated in other retroviral models, suggesting a possible role for IDO during LP-BM5-induced retroviral disease progression and/or development of viral load. Mice deficient in IDO (B6.IDO-/-) and wildtype C57BL/6 (B6) mice were infected with LP-BM5 murine retrovirus. MAIDS and LP-BM5 viral load were assessed at termination. As expected, IDO was un-inducible in B6.IDO-/- during LP-BM5 infection. B6.IDO-/- mice infected with LP-BM5 retrovirus succumbed to MAIDS as indicated by splenomegaly, serum hyper IgG2a and IgM, decreased responsiveness to B- and T-cell mitogens, conversion of a proportion of CD4+ T cells from Thy1.2+ to Thy1.2-, and increased percentages of CD11b+Gr-1+ cells. LP-BM5 infected B6.IDO-/- mice also demonstrated the development of roughly equivalent disease kinetics as compared to infected B6 mice. Splenic viral loads of B6 and B6.IDO-/- mice were also equivalent after infection as measured by LP-BM5-specific Def Gag and Eco Gag viral mRNA, determined by qRT-PCR. Collectively, these results demonstrate IDO neither plays an essential role, nor is required, in LP-BM5-induced disease progression or LP-BM5 viral load.

Hydrodynamic interactions induce movement against an external load in a ratchet dimer Brownian motor.

PubMed

Fornés, José A

2010-01-15

We use the Brownian dynamics with hydrodynamic interactions simulation in order to describe the movement of a elastically coupled dimer Brownian motor in a ratchet potential. The only external forces considered in our system were the load, the random thermal noise and an unbiased thermal fluctuation. For a given set of parameters we observe direct movement against the load force if hydrodynamic interactions were considered.

A microprocessor based portable bolt tension monitor

NASA Technical Reports Server (NTRS)

Perey, D. F.

1991-01-01

A bolt tension monitor (BTM) which uses ultrasonics and a pulsed phase locked loop circuit to measure load-induced acoustic phase shifts which are independent of friction is described. The BTM makes it possible to measure the load in a bolt that was tightened at some time in the past. This capability to recertify a load after-the-fact will help to insure the integrity of a bolted joint.

Effect of low or high glycemic load diets on experimentally induced mammary carcinogenesis in rats.

PubMed

Thompson, Henry J; Neuhouser, Marian L; Lampe, Johanna W; McGinley, John N; Neil, Elizabeth S; Schwartz, Yvonne; McTiernan, Anne

2016-06-01

High glycemic load diets have been associated with increased breast cancer risk in population-based studies, but the evidence is mixed. This investigation determined whether diets differing in glycemic load affected the carcinogenic process using a preclinical model. Human diets, formulated to differ 2-fold in glycemic load, were evaluated in the 1-methyl-nitrosourea-induced (37.5 mg/kg) mammary carcinogenesis model. Cancer incidence (23.3 versus 50.0%, p = 0.032), multiplicity, (0.40 versus 1.03, p = 0.030) and burden, (0.62 versus 1.19 g/rat, p = 0.037) were reduced in the low versus high glycemic load diets, respectively. However, the low glycemic protective effect was attenuated when two purified diets that differed in resistant starch and simulated the glycemic effects of the human diets were fed. Protection was associated with alterations in markers of cell growth regulation. Our findings show that human low or high glycemic load dietary patterns differentially affect the carcinogenic response in a nondiabetic rodent model for breast cancer. However, factors that are associated with these patterns, in addition to dietary carbohydrate availability, appear to account for the differences observed. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Development and application of a method for predicting rotor free wake positions and resulting rotor blade air loads. Volume 1: Model and results

NASA Technical Reports Server (NTRS)

Sadler, S. G.

1971-01-01

Rotor wake geometries are predicted by a process similar to the startup of a rotor in a free stream. An array of discrete trailing and shed vortices is generated with vortex strengths corresponding to stepwise radial and azimuthal blade circulations. The array of shed and trailing vortices is limited to an arbitrary number of azimuthal steps behind each blade. The remainder of the wake model of each blade is an arbitrary number of trailing vortices. Vortex element end points were allowed to be transported by the resultant velocity of the free stream and vortex-induced velocities. Wake geometry, wake flow, and wake-induced velocity influence coefficients are generated by this program for use in the blade loads portion of the calculations. Blade loads computations include the effects of nonuniform inflow due to a free wake, nonlinear airfoil characteristics, and response of flexible blades to the applied loads. Computed wake flows and blade loads are compared with experimentally measured data. Predicted blade loads, response and shears and moments are obtained for a model rotor system having two independent rotors. The effects of advance ratio, vertical separation of rotors, different blade radius ratios, and different azimuthal spacing of the blades of one rotor with respect to the other are investigated.

Load-induced modulation of signal transduction networks.

PubMed

Jiang, Peng; Ventura, Alejandra C; Sontag, Eduardo D; Merajver, Sofia D; Ninfa, Alexander J; Del Vecchio, Domitilla

2011-10-11

Biological signal transduction networks are commonly viewed as circuits that pass along information--in the process amplifying signals, enhancing sensitivity, or performing other signal-processing tasks--to transcriptional and other components. Here, we report on a "reverse-causality" phenomenon, which we call load-induced modulation. Through a combination of analytical and experimental tools, we discovered that signaling was modulated, in a surprising way, by downstream targets that receive the signal and, in doing so, apply what in physics is called a load. Specifically, we found that non-intuitive changes in response dynamics occurred for a covalent modification cycle when load was present. Loading altered the response time of a system, depending on whether the activity of one of the enzymes was maximal and the other was operating at its minimal rate or whether both enzymes were operating at submaximal rates. These two conditions, which we call "limit regime" and "intermediate regime," were associated with increased or decreased response times, respectively. The bandwidth, the range of frequency in which the system can process information, decreased in the presence of load, suggesting that downstream targets participate in establishing a balance between noise-filtering capabilities and a circuit's ability to process high-frequency stimulation. Nodes in a signaling network are not independent relay devices, but rather are modulated by their downstream targets.

Fabrication of Polymeric Micelles with Aggregation-Induced Emission and Forster Resonance Energy Transfer for Anticancer Drug Delivery.

PubMed

Hao, Na; Sun, Changzhen; Wu, Zhengfei; Xu, Long; Gao, Wenxia; Cao, Jun; Li, Li; He, Bin

2017-07-19

With the aim of obtaining effective cancer therapy with simultaneous cellular imaging, dynamic drug-release monitoring, and chemotherapeutic treatment, a polymeric micelle with aggregation-induced emission (AIE) imaging and a Forster resonance energy transfer (FRET) effect was fabricated as the drug carrier. An amphiphilic conjugate of 1H-pyrrole-1-propanoicacid (MAL)-poly(ethylene glycol) (PEG)-Tripp-bearing AIE molecules were synthesized and self-assembled into micelles to load the anticancer drug doxorubicin (DOX). Spherical DOX-loaded micelles with the mean size of 106 nm were obtained with good physiological stability (CMC, 12.5 μg/mL), high drug-loading capacity (10.4%), and encapsulation efficiency (86%). The cellular uptake behavior of DOX-loaded MAL-PEG-Tripp micelles was visible for high-quality intracellular imaging due to the AIE property. The delivery of DOX from the drug-loaded micelles was dynamic monitored by the FRET effect between the DOX and MAL-PEG-Tripp. Both in vitro (IC50, 2.36 μg/mL) and in vivo anticancer activity tests revealed that the DOX-loaded MAL-PEG-Tripp micelles exhibited promising therapeutic efficacy to cancer with low systematic toxicity. In summary, this micelle provided an effective way to fabricate novel nanoplatform for intracellular imaging, drug-delivery tracing, and chemotherapy.

Energy absorption behavior of polyurea coatings under laser-induced dynamic tensile and mixed-mode loading

NASA Astrophysics Data System (ADS)

Jajam, Kailash; Lee, Jaejun; Sottos, Nancy

2015-06-01

Energy absorbing, lightweight, thin transparent layers/coatings are desirable in many civilian and military applications such as hurricane resistant windows, personnel face-shields, helmet liners, aircraft canopies, laser shields, blast-tolerant sandwich structures, sound and vibration damping materials to name a few. Polyurea, a class of segmented block copolymer, has attracted recent attention for its energy absorbing properties. However, most of the dynamic property characterization of polyurea is limited to tensile and split-Hopkinson-pressure-bar compression loading experiments with strain rates on the order of 102 and 104 s-1, respectively. In the present work, we report the energy absorption behavior of polyurea thin films (1 to 2 μm) subjected to laser-induced dynamic tensile and mixed-mode loading. The laser-generated high amplitude stress wave propagates through the film in short time frames (15 to 20 ns) leading to very high strain rates (107 to 108 s-1) . The substrate stress, surface velocity and fluence histories are inferred from the displacement fringe data. On comparing input and output fluences, test results indicate significant energy absorption by the polyurea films under both tensile and mixed-mode loading conditions. Microscopic examination reveals distinct changes in failure mechanisms under mixed-mode loading from that observed under pure tensile loading. Office of Naval Research MURI.

Cancer-targeting siRNA delivery from porous silicon nanoparticles.

PubMed

Wan, Yuan; Apostolou, Sinoula; Dronov, Roman; Kuss, Bryone; Voelcker, Nicolas H

2014-10-01

Porous silicon nanoparticles (pSiNPs) with tunable pore size are biocompatible and biodegradable, suggesting that they are suitable biomaterials as vehicles for drug delivery. Loading of small interfering RNA (siRNA) into the pores of pSiNPs can protect siRNA from degradation as well as improve the cellular uptake. We aimed to deliver MRP1 siRNA loaded into pSiNPs to glioblastoma cells, and to demonstrate downregulation of MRP1 at the mRNA and protein levels. 50-220 nm pSiNPs with an average pore size of 26 nm were prepared, followed by electrostatic adsorption of siRNA into pores. Oligonucleotide loading and release profiles were investigated; MRP1 mRNA and protein expression, cell viability and cell apoptosis were studied. Approximately 7.7 µg of siRNA was loaded per mg of pSiNPs. Cells readily took up nanoparticles after 30 min incubation. siRNA-loaded pSiNPs were able to effectively downregulate target mRNA (~40%) and protein expression (31%), and induced cell apoptosis and necrosis (33%). siRNA loaded pSiNPs downregulated mRNA and protein expression and induced cell death. This novel siRNA delivery system may pave the way towards developing more effective tumor therapies.

NASA Exercise Physiology and Countermeasures Project Overview

NASA Technical Reports Server (NTRS)

Loerch, Linda; Ploutz-Snyder, Lori

2009-01-01

Efficient exercise countermeasures are necessary to offset or minimize spaceflight-induced deconditioning and to maximize crew performance of mission tasks. These countermeasure protocols should use the fewest crew and vehicle resources. NASA s Exercise Physiology and Countermeasures (ExPC) Project works to identify, collect, interpret, and summarize evidence that results in effective exercise countermeasure protocols which protect crew health and performance during International Space Station (ISS) and future exploration-class missions. The ExPC and NASA s Human Research Program are sponsoring multiple studies to evaluate and improve the efficacy of spaceflight exercise countermeasures. First, the Project will measure maximal aerobic capacity (VO2max) during cycle ergometry before, during, and after ISS missions. Second, the Project is sponsoring an evaluation of a new prototype harness that offers improved comfort and increased loading during treadmill operations. Third, the Functional Tasks Test protocol will map performance of anticipated lunar mission tasks with physiologic systems before and after short and long-duration spaceflight, to target system contributions and the tailoring of exercise protocols to maximize performance. In addition to these studies that are actively enrolling crewmember participants, the ExPC is planning new studies that include an evaluation of a higher-intensity/lower-volume exercise countermeasure protocol aboard the ISS using the Advanced Resistive Exercise Device and second-generation treadmill, studies that evaluate bone loading during spaceflight exercise, and ground-based studies that focus on fitness for duty standards required to complete lunar mission tasks and for which exercise protocols need to protect. Summaries of these current and future studies and strategies will be provided to international colleagues for knowledge sharing and possible collaboration.

Geophysical Signatures of Shear-Induced Damage and Frictional Processes on Rock Joints

NASA Astrophysics Data System (ADS)

Hedayat, Ahmadreza; Haeri, Hadi; Hinton, John; Masoumi, Hossein; Spagnoli, Giovanni

2018-02-01

In this study, ultrasonic waves recorded during direct shear experiments on rock joints were employed to investigate the shear failure processes. Three types of wave attributes were systematically observed prior to the shear failure of the rock joints: (a) maximum in the amplitude of the transmitted wave, (b) maximum in the dominant frequency of the transmitted wave, and (c) maximum in the velocity of the wave. Different processes occurring during both frictional sliding and stick-slip oscillations were identified in this study: (a) interseismic phase and (b) preseismic phase. The interseismic phase is associated with elastic loading, very small local slip rate, and increasing ultrasonic transmission along the contact surfaces. The rock joint is considered locked, and the increase in ultrasonic transmission represents an increase in the real (true) area of contact because of interlocking and contact aging. The start of the preseismic phase is marked by the onset of precursors for different regions of the rock joint. Following the interseismic and preseismic phases, coseismic phase occurs. The coseismic phase begins with the reduction in the applied shear stress and is associated with an abrupt increase in the local slip rate. The reductions in transmitted amplitude, wave velocity, and dominant frequency all indicate the preseismic phase when the asperity contacts begin to fail before macroscopic frictional sliding. The observation of the preseismic phase in both the loading phase leading to stable sliding and stick-slip failure modes suggests that microphysical processes of fault weakening may share key features for these two failure modes.

Hydrodynamic Interactions during Launch and Recovery of a Small Boat from a Ship in a Seaway

DTIC Science & Technology

2014-11-28

during launch and recovery. The RHIB is based on a Zodiac H935, with properties given in Table 1 when loaded with 12 person- nel. Figure 1 shows the hull...and recovery of a small craft from a larger ship, wave-induced motions of the larger ship will influence dy- namic loads on the crane. The motions of... the small craft will be a major determinant of the safety of onboard personnel. This paper exam- ines wave-induced motions during launch and recovery

Detecting fast and thermal neutrons with a boron loaded liquid scintillator, EJ-339A.

PubMed

Pino, F; Stevanato, L; Cester, D; Nebbia, G; Sajo-Bohus, L; Viesti, G

2014-09-01

A commercial boron-loaded liquid scintillator EJ-339 A was studied, using a (252)Cf source with/without polyethylene moderator, to examine the possibility of discriminating slow-neutron induced events in (10)B from fast-neutron events, resulting from proton recoils, and gamma-ray events. Despite the strong light quenching associated with neutron induced events in (10)B, correct classification of these events is shown to be possible with the aid of digital signal processing. Copyright © 2014 Elsevier Ltd. All rights reserved.

Fluid mass and thermal loading effects on the modal characteristics of space shuttle main engine liquid oxygen inlet splitter vanes

NASA Technical Reports Server (NTRS)

Panossian, H. V.; Boehnlein, J. J.

1987-01-01

An analysis and evaluation of experimental modal survey test data on the variations of modal characteristics induced by pressure and thermal loading events are presented. Extensive modal survey tests were carried out on a Space Shuttle Main Engine (SSME) test article using liquid nitrogen under cryogenic temperatures and high pressures. The results suggest that an increase of pressure under constant cryogenic temperature or a decrease of temperature under high pressure induces an upward shift of frequencies of various modes of the structures.

Generation of doubly charged vortex beam by concentrated loading of glass disks along their diameter.

PubMed

Skab, Ihor; Vasylkiv, Yuriy; Krupych, Oleh; Savaryn, Viktoriya; Vlokh, Rostyslav

2012-04-10

We show that a system of glass disks compressed along their diameters enables one to induce a doubly charged vortex beam in the emergent light when the incident light is circularly polarized. Using such a disk system, one can control the efficiency of conversion of the spin angular momentum to the orbital angular momentum by a loading force. The consideration presented here can be extended for the case of crystalline materials with high optical damage thresholds in order to induce high-power vortex beams.

Handling of induced hypercalcaemia in hyperthyroidism

PubMed Central

Lim, P.; Jacob, E.; Khoo, O. T.

1969-01-01

The mean serum calcium of 13 hyperthyroid patients was found to be significantly higher than that of controls matched for sex and age, though none of the patients' values were outside the normal range. Nevertheless, these patients responded very promptly to hypercalcaemia (induced by an intravenous calcium load), and their serum calcium returned to normal much more rapidly compared with the matched controls. There was also increased retention of intravenous calcium load, possibly owing to increased calcitonin production. Calcium infusion may be useful in treating bone diseases in which increased bone resorption exceeds bone accretion. PMID:5354875

The effects of induced heat loads on the propagation of Ince-Gaussian beams

NASA Astrophysics Data System (ADS)

Nadgaran, H.; Servatkhah, M.

2011-10-01

Thermal effects are very much influential in high power beam generators. Their impacts on special types of beams such as Helmholtz-Gauss beams have attracted special attentions. This work reports thermal effects on the generation and propagation of Ince-Gaussian beams. The results show considerable beam spot size variations for near fields under various induced heat loads. As Ince-Gaussian beams are directly related to cavity symmetry breaking, the results can greatly help system designers for circumventing these types of symmetry breaks usually encountered in high power lasers.

Wind effects on long-span bridges: Probabilistic wind data format for buffeting and VIV load assessments

NASA Astrophysics Data System (ADS)

Hoffmann, K.; Srouji, R. G.; Hansen, S. O.

2017-12-01

The technology development within the structural design of long-span bridges in Norwegian fjords has created a need for reformulating the calculation format and the physical quantities used to describe the properties of wind and the associated wind-induced effects on bridge decks. Parts of a new probabilistic format describing the incoming, undisturbed wind is presented. It is expected that a fixed probabilistic format will facilitate a more physically consistent and precise description of the wind conditions, which in turn increase the accuracy and considerably reduce uncertainties in wind load assessments. Because the format is probabilistic, a quantification of the level of safety and uncertainty in predicted wind loads is readily accessible. A simple buffeting response calculation demonstrates the use of probabilistic wind data in the assessment of wind loads and responses. Furthermore, vortex-induced fatigue damage is discussed in relation to probabilistic wind turbulence data and response measurements from wind tunnel tests.

In situ eNOS/NO up-regulation—a simple and effective therapeutic strategy for diabetic skin ulcer

PubMed Central

Yang, Ye; Yin, Dengke; Wang, Fei; Hou, Ziyan; Fang, Zhaohui

2016-01-01

Decreased nitric oxide (NO) synthesis and increased NO consumption in diabetes induces the inadequate blood flow to tissues that is primarily responsible for the pathogenesis and refractoriness of diabetic skin ulcers. The present study proposed a simple and effective therapeutic strategy for diabetic skin ulcers—in situ up-regulation of endothelial nitric oxide synthase (eNOS) expression and NO synthesis by statin-loaded tissue engineering scaffold (TES). In vitro experiments on human umbilical vein endothelial cells indicated that the statin-loaded TES relieved the high-glucose induced decrease in cell viability and promoted NO synthesis under high-glucose conditions. In a rat model of diabetes, the statin-loaded TES promoted eNOS expression and NO synthesis in/around the regenerated tissues. Subsequently, accelerated vascularization and elevated blood supply were observed, followed by rapid wound healing. These findings suggest that the in situ up-regulation of eNOS/NO by a statin-loaded TES may be a useful therapeutic method for intractable diabetic skin wounds. PMID:27453476

Influence of two-dimensional hygrothermal gradients on interlaminar stresses near free edges

NASA Technical Reports Server (NTRS)

Farley, G. L.; Herakovich, C. T.

1977-01-01

Interlaminar stresses are determined for mechanical loading, uniform hygrothermal loading, and gradient moisture loading through implementation of a finite element computer code. Nonuniform two-dimensional hygroscopic gradients are obtained from a finite difference solution of the diffusion equation. It is shown that hygroscopic induced stresses can be larger than those resulting from mechanical and thermal loading, and that the distribution of the interlaminar normal stress may be changed significantly in the presence of a two-dimensional moisture gradient in the boundary layer of a composite laminate.

Horizontal stresses induced by vertical processes in planetary lithospheres

NASA Technical Reports Server (NTRS)

Banerdt, W. B.

1993-01-01

Understanding the state of stress in the elastic lithosphere is of fundamental importance for planetary geophysics, as it is the link between the observed geologic structures on the surface and the processes which form and modify these structures. As such, it can provide valuable constraints for the difficult problem of determining interior structure and processes. On the Earth, most large scale, organized deformation can be related to lateral tectonics associated with plate dynamics; however, the tectonics on many extraterrestrial bodies (such as the Moon, Mars, and most of the outer-planet satellites) appears to be primarily vertical in nature, and the horizontal stresses induced by vertical motions and loads are expected to dominate the deformation of their lithospheres. The largest stress contributions from vertical loading come from the flexure of the lithosphere, which induces both bending moments and membrane stresses. We are concerned here only with nonflexural changes in the state of stress induced by processes such as sedimentary and volcanic deposition, erosional denudation, and changes in the thermal gradient that induce uplift or subsidence. This analysis is important both for evaluating stresses for specific regions in which the vertical stress history can be estimated, as well as for applying the proper loading conditions to global stress models. It is also of interest for providing a reference state of stress for interpreting stress measurements in the crust of the Earth.