Many-body localization in a long range XXZ model with random-field

NASA Astrophysics Data System (ADS)

Li, Bo

2016-12-01

Many-body localization (MBL) in a long range interaction XXZ model with random field are investigated. Using the exact diagonal method, the MBL phase diagram with different tuning parameters and interaction range is obtained. It is found that the phase diagram of finite size results supplies strong evidence to confirm that the threshold interaction exponent α = 2. The tuning parameter Δ can efficiently change the MBL edge in high energy density stats, thus the system can be controlled to transfer from thermal phase to MBL phase by changing Δ. The energy level statistics data are consistent with result of the MBL phase diagram. However energy level statistics data cannot detect the thermal phase correctly in extreme long range case.

Anticoagulant effects of inhaled unfractionated heparin in the dog as determined by partial thromboplastin time and factor Xa activity.

PubMed

Manion, Jill S; Thomason, John M; Langston, Vernon C; Claude, Andrew K; Brooks, Marjory B; Mackin, Andrew J; Lunsford, Kari V

2016-01-01

To evaluate the anticoagulant effects of inhaled heparin in dogs. This study was conducted in 3 phases. In phase 1, bronchoalveolar lavage fluid (BALf) was collected to generate an in vitro calibration curve to relate heparin concentration to the activated partial thromboplastin time (aPTT). In phase 2, heparin was administered via nebulization to determine the threshold dose needed to prolong systemic aPTT. In phase 3, the local anticoagulant activity of inhaled heparin was determined by measurement of BALf anti-Xa activity and aPTT. University teaching hospital. Six healthy intact female Walker Hounds were used in this study. Two dogs were used for each phase. Inhaled unfractionated sodium heparin was administered in doses ranging from 50,000 to 200,000 IU. In vitro addition of heparin to BALf caused a prolongation in aPTT. Inhaled heparin at doses as high as 200,000 IU failed to prolong systemic aPTT, and a threshold dose could not be determined. No significant local anticoagulant effects were detected. Even at doses higher than those known to be effective in people, inhaled heparin appears to have no detectable local or systemic anticoagulant effects in dogs with the current delivery method. © Veterinary Emergency and Critical Care Society 2015.

Direct detection of metal-insulator phase transitions using the modified Backus-Gilbert method

NASA Astrophysics Data System (ADS)

Ulybyshev, Maksim; Winterowd, Christopher; Zafeiropoulos, Savvas

2018-03-01

The detection of the (semi)metal-insulator phase transition can be extremely difficult if the local order parameter which characterizes the ordered phase is unknown. In some cases, it is even impossible to define a local order parameter: the most prominent example of such system is the spin liquid state. This state was proposed to exist in the Hubbard model on the hexagonal lattice in a region between the semimetal phase and the antiferromagnetic insulator phase. The existence of this phase has been the subject of a long debate. In order to detect these exotic phases we must use alternative methods to those used for more familiar examples of spontaneous symmetry breaking. We have modified the Backus-Gilbert method of analytic continuation which was previously used in the calculation of the pion quasiparticle mass in lattice QCD. The modification of the method consists of the introduction of the Tikhonov regularization scheme which was used to treat the ill-conditioned kernel. This modified Backus-Gilbert method is applied to the Euclidean propagators in momentum space calculated using the hybrid Monte Carlo algorithm. In this way, it is possible to reconstruct the full dispersion relation and to estimate the mass gap, which is a direct signal of the transition to the insulating state. We demonstrate the utility of this method in our calculations for the Hubbard model on the hexagonal lattice. We also apply the method to the metal-insulator phase transition in the Hubbard-Coulomb model on the square lattice.

Imaging of tumor hypermetabolism with near-infrared fluorescence contrast agents

NASA Astrophysics Data System (ADS)

Chen, Yu; Zheng, Gang; Zhang, Zhihong; Blessington, Dana; Intes, Xavier; Achilefu, Samuel I.; Chance, Britton

2004-08-01

We have developed a high sensitivity near-infrared (NIR) optical imaging system for non-invasive cancer detection through molecular labeled fluorescent contrast agents. Near-infrared (NIR) imaging can probe tissue deeply thus possess the potential for non-invasively detection of breast or lymph node cancer. Recent developments in molecular beacons can selectively label various pre-cancer/cancer signatures and provide high tumor to background contrast. To increase the sensitivity in detecting fluorescent photons and the accuracy of localization, phase cancellation (in- and anti-phase) device is employed. This frequency-domain system utilizes the interference-like pattern of diffuse photon density wave to achieve high detection sensitivity and localization accuracy for the fluorescent heterogeneity embedded inside the scattering media. The opto-electronic system consists of the laser sources, fiber optics, interference filter to select the fluorescent photons and the high sensitivity photon detector (photomultiplier tube). The source-detector pair scans the tissue surface in multiple directions and the two-dimensional localization image can be obtained using goniometric reconstruction. In vivo measurements with tumor-bearing mouse model using the novel Cypate-mono-2-deoxy-glucose (Cypate-2-D-Glucosamide) fluorescent contrast agent, which targets the enhanced tumor glycolysis, demonstrated the feasibility on detection of 2 cm deep subsurface tumor in the tissue-like medium, with a localization accuracy within 2 ~ 3 mm. This instrument has the potential for tumor diagnosis and imaging, and the accuracy of the localization suggests that this system could help to guide the clinical fine-needle biopsy. This portable device would be complementary to X-ray mammogram and provide add-on information on early diagnosis and localization of early breast tumor.

Coherent Detection of High-Rate Optical PPM Signals

NASA Technical Reports Server (NTRS)

Vilnrotter, Victor; Fernandez, Michela Munoz

2006-01-01

A method of coherent detection of high-rate pulse-position modulation (PPM) on a received laser beam has been conceived as a means of reducing the deleterious effects of noise and atmospheric turbulence in free-space optical communication using focal-plane detector array technologies. In comparison with a receiver based on direct detection of the intensity modulation of a PPM signal, a receiver based on the present method of coherent detection performs well at much higher background levels. In principle, the coherent-detection receiver can exhibit quantum-limited performance despite atmospheric turbulence. The key components of such a receiver include standard receiver optics, a laser that serves as a local oscillator, a focal-plane array of photodetectors, and a signal-processing and data-acquisition assembly needed to sample the focal-plane fields and reconstruct the pulsed signal prior to detection. The received PPM-modulated laser beam and the local-oscillator beam are focused onto the photodetector array, where they are mixed in the detection process. The two lasers are of the same or nearly the same frequency. If the two lasers are of different frequencies, then the coherent detection process is characterized as heterodyne and, using traditional heterodyne-detection terminology, the difference between the two laser frequencies is denoted the intermediate frequency (IF). If the two laser beams are of the same frequency and remain aligned in phase, then the coherent detection process is characterized as homodyne (essentially, heterodyne detection at zero IF). As a result of the inherent squaring operation of each photodetector, the output current includes an IF component that contains the signal modulation. The amplitude of the IF component is proportional to the product of the local-oscillator signal amplitude and the PPM signal amplitude. Hence, by using a sufficiently strong local-oscillator signal, one can make the PPM-modulated IF signal strong enough to overcome thermal noise in the receiver circuits: this is what makes it possible to achieve near-quantum-limited detection in the presence of strong background. Following quantum-limited coherent detection, the outputs of the individual photodetectors are automatically aligned in phase by use of one or more adaptive array compensation algorithms [e.g., the least-mean-square (LMS) algorithm]. Then the outputs are combined and the resulting signal is processed to extract the high-rate information, as though the PPM signal were received by a single photodetector. In a continuing series of experiments to test this method (see Fig. 1), the local oscillator has a wavelength of 1,064 nm, and another laser is used as a signal transmitter at a slightly different wavelength to establish an IF of about 6 MHz. There are 16 photodetectors in a 4 4 focal-plane array; the detector outputs are digitized at a sampling rate of 25 MHz, and the signals in digital form are combined by use of the LMS algorithm. Convergence of the adaptive combining algorithm in the presence of simulated atmospheric turbulence for optical PPM signals has already been demonstrated in the laboratory; the combined output is shown in Fig. 2(a), and Fig. 2(b) shows the behavior of the phase of the combining weights as a function of time (or samples). We observe that the phase of the weights has a sawtooth shape due to the continuously changing phase in the down-converted output, which is not exactly at zero frequency. Detailed performance analysis of this coherent free-space optical communication system in the presence of simulated atmospheric turbulence is currently under way.

Coherent control at its most fundamental: carrier-envelope-phase-dependent electron localization in photodissociation of a H2(+) molecular ion beam target.

PubMed

Rathje, T; Sayler, A M; Zeng, S; Wustelt, P; Figger, H; Esry, B D; Paulus, G G

2013-08-30

Measurements and calculations of the absolute carrier-envelope-phase (CEP) effects in the photodissociation of the simplest molecule, H2(+), with a 4.5-fs Ti:sapphire laser pulse at intensities up to (4±2)×10(14)  W/cm2 are presented. Localization of the electron with respect to the two nuclei (during the dissociation process) is controlled via the CEP of the ultrashort laser pulses. In contrast to previous CEP-dependent experiments with neutral molecules, the dissociation of the molecular ions is not preceded by a photoionization process, which strongly influences the CEP dependence. Kinematically complete data are obtained by time- and position-resolved coincidence detection. The phase dependence is determined by a single-shot phase measurement correlated to the detection of the dissociation fragments. The experimental results show quantitative agreement with ab initio 3D time-dependent Schrödinger equation calculations that include nuclear vibration and rotation.

Robust automatic P-phase picking: an on-line implementation in the analysis of broadband seismogram recordings

NASA Astrophysics Data System (ADS)

Sleeman, Reinoud; van Eck, Torild

1999-06-01

The onset of a seismic signal is determined through joint AR modeling of the noise and the seismic signal, and the application of the Akaike Information Criterion (AIC) using the onset time as parameter. This so-called AR-AIC phase picker has been tested successfully and implemented on the Z-component of the broadband station HGN to provide automatic P-phase picks for a rapid warning system. The AR-AIC picker is shown to provide accurate and robust automatic picks on a large experimental database. Out of 1109 P-phase onsets with signal-to-noise ratio (SNR) above 1 from local, regional and teleseismic earthquakes, our implementation detects 71% and gives a mean difference with manual picks of 0.1 s. An optimal version of the well-established picker of Baer and Kradolfer [Baer, M., Kradolfer, U., An automatic phase picker for local and teleseismic events, Bull. Seism. Soc. Am. 77 (1987) 1437-1445] detects less than 41% and gives a mean difference with manual picks of 0.3 s using the same dataset.

Entanglement Properties and Quantum Phases for a Fermionic Disordered One-Dimensional Wire with Attractive Interactions.

PubMed

Berkovits, Richard

2015-11-13

A fermionic disordered one-dimensional wire in the presence of attractive interactions is known to have two distinct phases, a localized and superconducting, depending on the strength of interaction and disorder. The localized region may also exhibit a metallic behavior if the system size is shorter than the localization length. Here we show that the superconducting phase has a distribution of the entanglement entropy distinct from the metallic regime. The entanglement entropy distribution is strongly asymmetric with a Lévy α-stable distribution (compared to the Gaussian metallic distribution), as is seen also for the second Rényi entropy distribution. Thus, entanglement properties may reveal properties which cannot be detected by other methods.

Phase retrieval in digital speckle pattern interferometry by application of two-dimensional active contours called snakes.

PubMed

Federico, Alejandro; Kaufmann, Guillermo H

2006-03-20

We propose a novel approach to retrieving the phase map coded by a single closed-fringe pattern in digital speckle pattern interferometry, which is based on the estimation of the local sign of the quadrature component. We obtain the estimate by calculating the local orientation of the fringes that have previously been denoised by a weighted smoothing spline method. We carry out the procedure of sign estimation by determining the local abrupt jumps of size pi in the orientation field of the fringes and by segmenting the regions defined by these jumps. The segmentation method is based on the application of two-dimensional active contours (snakes), with which one can also estimate absent jumps, i.e., those that cannot be detected from the local orientation of the fringes. The performance of the proposed phase-retrieval technique is evaluated for synthetic and experimental fringes and compared with the results obtained with the spiral-phase- and Fourier-transform methods.

A very high frequency radio interferometer for investigating ionospheric disturbances using geostationary satellites. Determination of changes in exospheric electron content by a comparison of group delay and Faraday rotation

NASA Technical Reports Server (NTRS)

Terry, R.; Flaherty, B. J.; Dubroff, R. E.

1972-01-01

The theory and development of a VHF correlation radio interferometer for investigating ionospheric disturbances are discussed. The system was developed to receive signals from the geostationary Applications Technology Satellites. Amplitude and phase variations of the signal passing through the ionosphere can be detected by this instrument. The system consists of two superheterodyne receivers separated by a distance known as the baseline of the system. Since the system is a phase sensitive instrument, the local oscillators of the two receivers must be phase coherent. This is accomplished by using phase-locked loops for generating the local oscillators. The two signals from the separate receivers are cross-correlated by multiplying the two signals together and then time averaging the result. The sensitivity of the instrument is increased by off-setting one of the local oscillators by a small amount.

Detecting local heterogeneity and ionization ability in the head group region of different lipidic phases using modified fluorescent probes

NASA Astrophysics Data System (ADS)

Abou-Zied, Osama K.; Zahid, N. Idayu; Khyasudeen, M. Faisal; Giera, David S.; Thimm, Julian C.; Hashim, Rauzah

2015-03-01

Local heterogeneity in lipid self-assembly is important for executing the cellular membrane functions. In this work, we chemically modified 2-(2'-hydroxyphenyl)benzoxazole (HBO) and attached a C8 alkyl chain in two different locations to probe the microscopic environment of four lipidic phases of dodecyl β-maltoside. The fluorescence change in HBO and the new probes (HBO-1 and HBO-2) shows that in all phases (micellar, hexagonal, cubic and lamellar) three HBO tautomeric species (solvated syn-enol, anionic, and closed syn-keto) are stable. The formation of multi tautomers reflects the heterogeneity of the lipidic phases. The results indicate that HBO and HBO-1 reside in a similar location within the head group region, whereas HBO-2 is slightly pushed away from the sugar-dominated area. The stability of the solvated syn-enol tautomer is due to the formation of a hydrogen bond between the OH group of the HBO moiety and an adjacent oxygen atom of a sugar unit. The detected HBO anions was proposed to be a consequence of this solvation effect where a hydrogen ion abstraction by the sugar units is enhanced. Our results point to a degree of local heterogeneity and ionization ability in the head group region as a consequence of the sugar amphoterism.

Experiments in ultrasonic flaw detection using a MEMS transducer

NASA Astrophysics Data System (ADS)

Jain, Akash; Greve, David W.; Oppenheim, Irving J.

2003-08-01

In earlier work we developed a MEMS phased array transducer, fabricated in the MUMPs process, and we reported on initial experimental studies in which the device was affixed into contact with solids. We demonstrated the successful detection of signals from a conventional ultrasonic source, and the successful localization of the source in an off-axis geometry using phased array signal processing. We now describe the predicted transmission and coupling characteristics for such devices in contact with solids, demonstrating reasonable agreement with experimental behavior. We then describe the results of flaw detection experiments, as well as results for fluid-coupled detectors.

Heterodyne detection using spectral line pairing for spectral phase encoding optical code division multiple access and dynamic dispersion compensation.

PubMed

Yang, Yi; Foster, Mark; Khurgin, Jacob B; Cooper, A Brinton

2012-07-30

A novel coherent optical code-division multiple access (OCDMA) scheme is proposed that uses spectral line pairing to generate signals suitable for heterodyne decoding. Both signal and local reference are transmitted via a single optical fiber and a simple balanced receiver performs sourceless heterodyne detection, canceling speckle noise and multiple-access interference (MAI). To validate the idea, a 16 user fully loaded phase encoded system is simulated. Effects of fiber dispersion on system performance are studied as well. Both second and third order dispersion management is achieved by using a spectral phase encoder to adjust phase shifts of spectral components at the optical network unit (ONU).

Entanglement convertibility by sweeping through the quantum phases of the alternating bonds XXZ chain

PubMed Central

Tzeng, Yu-Chin; Dai, Li; Chung, Ming-Chiang; Amico, Luigi; Kwek, Leong-Chuan

2016-01-01

We study the entanglement structure and the topological edge states of the ground state of the spin-1/2 XXZ model with bond alternation. We employ parity-density matrix renormalization group with periodic boundary conditions. The finite-size scaling of Rényi entropies S2 and S∞ are used to construct the phase diagram of the system. The phase diagram displays three possible phases: Haldane type (an example of symmetry protected topological ordered phases), Classical Dimer and Néel phases, the latter bounded by two continuous quantum phase transitions. The entanglement and non-locality in the ground state are studied and quantified by the entanglement convertibility. We found that, at small spatial scales, the ground state is not convertible within the topological Haldane dimer phase. The phenomenology we observe can be described in terms of correlations between edge states. We found that the entanglement spectrum also exhibits a distinctive response in the topological phase: the effective rank of the reduced density matrix displays a specifically large “susceptibility” in the topological phase. These findings support the idea that although the topological order in the ground state cannot be detected by local inspection, the ground state response at local scale can tell the topological phases apart from the non-topological phases. PMID:27216970

Entanglement convertibility by sweeping through the quantum phases of the alternating bonds XXZ chain.

PubMed

Tzeng, Yu-Chin; Dai, Li; Chung, Ming-Chiang; Amico, Luigi; Kwek, Leong-Chuan

2016-05-24

We study the entanglement structure and the topological edge states of the ground state of the spin-1/2 XXZ model with bond alternation. We employ parity-density matrix renormalization group with periodic boundary conditions. The finite-size scaling of Rényi entropies S2 and S∞ are used to construct the phase diagram of the system. The phase diagram displays three possible phases: Haldane type (an example of symmetry protected topological ordered phases), Classical Dimer and Néel phases, the latter bounded by two continuous quantum phase transitions. The entanglement and non-locality in the ground state are studied and quantified by the entanglement convertibility. We found that, at small spatial scales, the ground state is not convertible within the topological Haldane dimer phase. The phenomenology we observe can be described in terms of correlations between edge states. We found that the entanglement spectrum also exhibits a distinctive response in the topological phase: the effective rank of the reduced density matrix displays a specifically large "susceptibility" in the topological phase. These findings support the idea that although the topological order in the ground state cannot be detected by local inspection, the ground state response at local scale can tell the topological phases apart from the non-topological phases.

Patch-based automatic retinal vessel segmentation in global and local structural context.

PubMed

Cao, Shuoying; Bharath, Anil A; Parker, Kim H; Ng, Jeffrey

2012-01-01

In this paper, we extend our published work [1] and propose an automated system to segment retinal vessel bed in digital fundus images with enough adaptability to analyze images from fluorescein angiography. This approach takes into account both the global and local context and enables both vessel segmentation and microvascular centreline extraction. These tools should allow researchers and clinicians to estimate and assess vessel diameter, capillary blood volume and microvascular topology for early stage disease detection, monitoring and treatment. Global vessel bed segmentation is achieved by combining phase-invariant orientation fields with neighbourhood pixel intensities in a patch-based feature vector for supervised learning. This approach is evaluated against benchmarks on the DRIVE database [2]. Local microvascular centrelines within Regions-of-Interest (ROIs) are segmented by linking the phase-invariant orientation measures with phase-selective local structure features. Our global and local structural segmentation can be used to assess both pathological structural alterations and microemboli occurrence in non-invasive clinical settings in a longitudinal study.

In-Situ Phase Transition Control in the Supercooled State for Robust Active Glass Fiber.

PubMed

Lv, Shichao; Cao, Maoqing; Li, Chaoyu; Li, Jiang; Qiu, Jianrong; Zhou, Shifeng

2017-06-21

The construction of a dopant-activated photonic composite is of great technological importance for various applications, including smart lighting, optical amplification, laser, and optical detection. The bonding arrangement around the introduced dopants largely determines the properties, yet it remains a daunting challenge to manipulate the local state of the matrix (i.e., phase) inside the transparent composite in a controllable manner. Here we demonstrate that the relaxation of the supercooled state enables in-situ phase transition control in glass. Benefiting from the unique local atom arrangement manner, the strategy offers the possibility for simultaneously tuning the chemical environment of the incorporated dopant and engineering the dopant-host interaction. This allows us to effectively activate the dopant with high efficiency (calculated as ∼100%) and profoundly enhance the dopant-host energy-exchange interaction. Our results highlight that the in-situ phase transition control in glass may provide new opportunities for fabrication of unusual photonic materials with intense broadband emission at ∼1100 nm and development of the robust optical detection unit with high compactness and broadband photon-harvesting capability (from X-ray to ultraviolet light).

Joint detection and localization of multiple anatomical landmarks through learning

NASA Astrophysics Data System (ADS)

Dikmen, Mert; Zhan, Yiqiang; Zhou, Xiang Sean

2008-03-01

Reliable landmark detection in medical images provides the essential groundwork for successful automation of various open problems such as localization, segmentation, and registration of anatomical structures. In this paper, we present a learning-based system to jointly detect (is it there?) and localize (where?) multiple anatomical landmarks in medical images. The contributions of this work exist in two aspects. First, this method takes the advantage from the learning scenario that is able to automatically extract the most distinctive features for multi-landmark detection. Therefore, it is easily adaptable to detect arbitrary landmarks in various kinds of imaging modalities, e.g., CT, MRI and PET. Second, the use of multi-class/cascaded classifier architecture in different phases of the detection stage combined with robust features that are highly efficient in terms of computation time enables a seemingly real time performance, with very high localization accuracy. This method is validated on CT scans of different body sections, e.g., whole body scans, chest scans and abdominal scans. Aside from improved robustness (due to the exploitation of spatial correlations), it gains a run time efficiency in landmark detection. It also shows good scalability performance under increasing number of landmarks.

An Improved Compressive Sensing and Received Signal Strength-Based Target Localization Algorithm with Unknown Target Population for Wireless Local Area Networks.

PubMed

Yan, Jun; Yu, Kegen; Chen, Ruizhi; Chen, Liang

2017-05-30

In this paper a two-phase compressive sensing (CS) and received signal strength (RSS)-based target localization approach is proposed to improve position accuracy by dealing with the unknown target population and the effect of grid dimensions on position error. In the coarse localization phase, by formulating target localization as a sparse signal recovery problem, grids with recovery vector components greater than a threshold are chosen as the candidate target grids. In the fine localization phase, by partitioning each candidate grid, the target position in a grid is iteratively refined by using the minimum residual error rule and the least-squares technique. When all the candidate target grids are iteratively partitioned and the measurement matrix is updated, the recovery vector is re-estimated. Threshold-based detection is employed again to determine the target grids and hence the target population. As a consequence, both the target population and the position estimation accuracy can be significantly improved. Simulation results demonstrate that the proposed approach achieves the best accuracy among all the algorithms compared.

The Applicability of Incoherent Array Processing to IMS Seismic Array Stations

NASA Astrophysics Data System (ADS)

Gibbons, S. J.

2012-04-01

The seismic arrays of the International Monitoring System for the CTBT differ greatly in size and geometry, with apertures ranging from below 1 km to over 60 km. Large and medium aperture arrays with large inter-site spacings complicate the detection and estimation of high frequency phases since signals are often incoherent between sensors. Many such phases, typically from events at regional distances, remain undetected since pipeline algorithms often consider only frequencies low enough to allow coherent array processing. High frequency phases that are detected are frequently attributed qualitatively incorrect backazimuth and slowness estimates and are consequently not associated with the correct event hypotheses. This can lead to missed events both due to a lack of contributing phase detections and by corruption of event hypotheses by spurious detections. Continuous spectral estimation can be used for phase detection and parameter estimation on the largest aperture arrays, with phase arrivals identified as local maxima on beams of transformed spectrograms. The estimation procedure in effect measures group velocity rather than phase velocity and the ability to estimate backazimuth and slowness requires that the spatial extent of the array is large enough to resolve time-delays between envelopes with a period of approximately 4 or 5 seconds. The NOA, AKASG, YKA, WRA, and KURK arrays have apertures in excess of 20 km and spectrogram beamforming on these stations provides high quality slowness estimates for regional phases without additional post-processing. Seven arrays with aperture between 10 and 20 km (MJAR, ESDC, ILAR, KSRS, CMAR, ASAR, and EKA) can provide robust parameter estimates subject to a smoothing of the resulting slowness grids, most effectively achieved by convolving the measured slowness grids with the array response function for a 4 or 5 second period signal. The MJAR array in Japan recorded high SNR Pn signals for both the 2006 and 2009 North Korea nuclear tests but, due to signal incoherence, failed to contribute to the automatic event detections. It is demonstrated that the smoothed incoherent slowness estimates for the MJAR Pn phases for both tests indicate unambiguously the correct type of phase and a backazimuth estimate within 5 degrees of the great-circle backazimuth. The detection part of the algorithm is applicable to all IMS arrays, and spectrogram-based processing may offer a reduction in the false alarm rate for high frequency signals. Significantly, the local maxima of the scalar functions derived from the transformed spectrogram beams provide good estimates of the signal onset time. High frequency energy is of greater significance for lower event magnitudes and in, for example, the cavity decoupling detection evasion scenario. There is a need to characterize propagation paths with low attenuation of high frequency energy and situations in which parameter estimation on array stations fails.

A Matched Field Processing Framework for Coherent Detection Over Local and Regional Networks (Postprint)

DTIC Science & Technology

2011-12-30

the term " superresolution "). The single-phase matched field statistic for a given template was also demonstrated to be a viable detection statistic... Superresolution with seismic arrays using empirical matched field processing, Geophys. J. Int. 182: 1455–1477. Kim, K.-H. and Park, Y. (2010): The 20

Aqueous two-phase system patterning of detection antibody solutions for cross-reaction-free multiplex ELISA

NASA Astrophysics Data System (ADS)

Frampton, John P.; White, Joshua B.; Simon, Arlyne B.; Tsuei, Michael; Paczesny, Sophie; Takayama, Shuichi

2014-05-01

Accurate disease diagnosis, patient stratification and biomarker validation require the analysis of multiple biomarkers. This paper describes cross-reactivity-free multiplexing of enzyme-linked immunosorbent assays (ELISAs) using aqueous two-phase systems (ATPSs) to confine detection antibodies at specific locations in fully aqueous environments. Antibody cross-reactions are eliminated because the detection antibody solutions are co-localized only to corresponding surface-immobilized capture antibody spots. This multiplexing technique is validated using plasma samples from allogeneic bone marrow recipients. Patients with acute graft versus host disease (GVHD), a common and serious condition associated with allogeneic bone marrow transplantation, display higher mean concentrations for four multiplexed biomarkers (HGF, elafin, ST2 and TNFR1) relative to healthy donors and transplant patients without GVHD. The antibody co-localization capability of this technology is particularly useful when using inherently cross-reactive reagents such as polyclonal antibodies, although monoclonal antibody cross-reactivity can also be reduced. Because ATPS-ELISA adapts readily available antibody reagents, plate materials and detection instruments, it should be easily transferable into other research and clinical settings.

Aqueous two-phase system patterning of detection antibody solutions for cross-reaction-free multiplex ELISA

PubMed Central

Frampton, John P.; White, Joshua B.; Simon, Arlyne B.; Tsuei, Michael; Paczesny, Sophie; Takayama, Shuichi

2014-01-01

Accurate disease diagnosis, patient stratification and biomarker validation require the analysis of multiple biomarkers. This paper describes cross-reactivity-free multiplexing of enzyme-linked immunosorbent assays (ELISAs) using aqueous two-phase systems (ATPSs) to confine detection antibodies at specific locations in fully aqueous environments. Antibody cross-reactions are eliminated because the detection antibody solutions are co-localized only to corresponding surface-immobilized capture antibody spots. This multiplexing technique is validated using plasma samples from allogeneic bone marrow recipients. Patients with acute graft versus host disease (GVHD), a common and serious condition associated with allogeneic bone marrow transplantation, display higher mean concentrations for four multiplexed biomarkers (HGF, elafin, ST2 and TNFR1) relative to healthy donors and transplant patients without GVHD. The antibody co-localization capability of this technology is particularly useful when using inherently cross-reactive reagents such as polyclonal antibodies, although monoclonal antibody cross-reactivity can also be reduced. Because ATPS-ELISA adapts readily available antibody reagents, plate materials and detection instruments, it should be easily transferable into other research and clinical settings. PMID:24786974

Detecting Abrupt Changes in a Piecewise Locally Stationary Time Series

PubMed Central

Last, Michael; Shumway, Robert

2007-01-01

Non-stationary time series arise in many settings, such as seismology, speech-processing, and finance. In many of these settings we are interested in points where a model of local stationarity is violated. We consider the problem of how to detect these change-points, which we identify by finding sharp changes in the time-varying power spectrum. Several different methods are considered, and we find that the symmetrized Kullback-Leibler information discrimination performs best in simulation studies. We derive asymptotic normality of our test statistic, and consistency of estimated change-point locations. We then demonstrate the technique on the problem of detecting arrival phases in earthquakes. PMID:19190715

Comparison of pelvic phased-array versus endorectal coil magnetic resonance imaging at 3 Tesla for local staging of prostate cancer.

PubMed

Kim, Bum Soo; Kim, Tae-Hwan; Kwon, Tae Gyun; Yoo, Eun Sang

2012-05-01

Several studies have demonstrated the superiority of endorectal coil magnetic resonance imaging (MRI) over pelvic phased-array coil MRI at 1.5 Tesla for local staging of prostate cancer. However, few have studied which evaluation is more accurate at 3 Tesla MRI. In this study, we compared the accuracy of local staging of prostate cancer using pelvic phased-array coil or endorectal coil MRI at 3 Tesla. Between January 2005 and May 2010, 151 patients underwent radical prostatectomy. All patients were evaluated with either pelvic phased-array coil or endorectal coil prostate MRI prior to surgery (63 endorectal coils and 88 pelvic phased-array coils). Tumor stage based on MRI was compared with pathologic stage. We calculated the specificity, sensitivity and accuracy of each group in the evaluation of extracapsular extension and seminal vesicle invasion. Both endorectal coil and pelvic phased-array coil MRI achieved high specificity, low sensitivity and moderate accuracy for the detection of extracapsular extension and seminal vesicle invasion. There were statistically no differences in specificity, sensitivity and accuracy between the two groups. Overall staging accuracy, sensitivity and specificity were not significantly different between endorectal coil and pelvic phased-array coil MRI.

Experimental phase synchronization detection in non-phase coherent chaotic systems by using the discrete complex wavelet approach

NASA Astrophysics Data System (ADS)

Ferreira, Maria Teodora; Follmann, Rosangela; Domingues, Margarete O.; Macau, Elbert E. N.; Kiss, István Z.

2017-08-01

Phase synchronization may emerge from mutually interacting non-linear oscillators, even under weak coupling, when phase differences are bounded, while amplitudes remain uncorrelated. However, the detection of this phenomenon can be a challenging problem to tackle. In this work, we apply the Discrete Complex Wavelet Approach (DCWA) for phase assignment, considering signals from coupled chaotic systems and experimental data. The DCWA is based on the Dual-Tree Complex Wavelet Transform (DT-CWT), which is a discrete transformation. Due to its multi-scale properties in the context of phase characterization, it is possible to obtain very good results from scalar time series, even with non-phase-coherent chaotic systems without state space reconstruction or pre-processing. The method correctly predicts the phase synchronization for a chemical experiment with three locally coupled, non-phase-coherent chaotic processes. The impact of different time-scales is demonstrated on the synchronization process that outlines the advantages of DCWA for analysis of experimental data.

Generation and coherent detection of QPSK signal using a novel method of digital signal processing

NASA Astrophysics Data System (ADS)

Zhao, Yuan; Hu, Bingliang; He, Zhen-An; Xie, Wenjia; Gao, Xiaohui

2018-02-01

We demonstrate an optical quadrature phase-shift keying (QPSK) signal transmitter and an optical receiver for demodulating optical QPSK signal with homodyne detection and digital signal processing (DSP). DSP on the homodyne detection scheme is employed without locking the phase of the local oscillator (LO). In this paper, we present an extracting one-dimensional array of down-sampling method for reducing unwanted samples of constellation diagram measurement. Such a novel scheme embodies the following major advantages over the other conventional optical QPSK signal detection methods. First, this homodyne detection scheme does not need strict requirement on LO in comparison with linear optical sampling, such as having a flat spectral density and phase over the spectral support of the source under test. Second, the LabVIEW software is directly used for recovering the QPSK signal constellation without employing complex DSP circuit. Third, this scheme is applicable to multilevel modulation formats such as M-ary PSK and quadrature amplitude modulation (QAM) or higher speed signals by making minor changes.

Drogue detection for vision-based autonomous aerial refueling via low rank and sparse decomposition with multiple features

NASA Astrophysics Data System (ADS)

Gao, Shibo; Cheng, Yongmei; Song, Chunhua

2013-09-01

The technology of vision-based probe-and-drogue autonomous aerial refueling is an amazing task in modern aviation for both manned and unmanned aircraft. A key issue is to determine the relative orientation and position of the drogue and the probe accurately for relative navigation system during the approach phase, which requires locating the drogue precisely. Drogue detection is a challenging task due to disorderly motion of drogue caused by both the tanker wake vortex and atmospheric turbulence. In this paper, the problem of drogue detection is considered as a problem of moving object detection. A drogue detection algorithm based on low rank and sparse decomposition with local multiple features is proposed. The global and local information of drogue is introduced into the detection model in a unified way. The experimental results on real autonomous aerial refueling videos show that the proposed drogue detection algorithm is effective.

Dynamic CT for parathyroid disease: are multiple phases necessary?

PubMed

Raghavan, P; Durst, C R; Ornan, D A; Mukherjee, S; Wintermark, M; Patrie, J T; Xin, W; Shada, A L; Hanks, J B; Smith, P W

2014-10-01

A 4D CT protocol for detection of parathyroid lesions involves obtaining unenhanced, arterial, early, and delayed venous phase images. The aim of the study was to determine the ideal combination of phases that would minimize radiation dose without sacrificing diagnostic accuracy. With institutional review board approval, the records of 29 patients with primary hyperparathyroidism who had undergone surgical exploration were reviewed. Four neuroradiologists who were blinded to the surgical outcome reviewed the imaging studies in 5 combinations (unenhanced and arterial phase; unenhanced, arterial, and early venous; all 4 phases; arterial alone; arterial and early venous phases) with an interval of at least 7 days between each review. The accuracy of interpretation in lateralizing an abnormality to the side of the neck (right, left, ectopic) and localizing it to a quadrant in the neck (right or left upper, right or left lower) was evaluated. The lateralization and localization accuracy (90.5% and 91.5%, respectively) of the arterial phase alone was comparable with the other combinations of phases. There was no statistically significant difference among the different combinations of phases in their ability to lateralize or localize adenomas to a quadrant (P = .976 and .996, respectively). Assessment of a small group of patients shows that adequate diagnostic accuracy for parathyroid adenoma localization may be achievable by obtaining arterial phase images alone. If this outcome can be validated prospectively in a larger group of patients, then the radiation dose can potentially be reduced to one-fourth of what would otherwise be administered. © 2014 by American Journal of Neuroradiology.

Fly Photoreceptors Encode Phase Congruency

PubMed Central

Friederich, Uwe; Billings, Stephen A.; Hardie, Roger C.; Juusola, Mikko; Coca, Daniel

2016-01-01

More than five decades ago it was postulated that sensory neurons detect and selectively enhance behaviourally relevant features of natural signals. Although we now know that sensory neurons are tuned to efficiently encode natural stimuli, until now it was not clear what statistical features of the stimuli they encode and how. Here we reverse-engineer the neural code of Drosophila photoreceptors and show for the first time that photoreceptors exploit nonlinear dynamics to selectively enhance and encode phase-related features of temporal stimuli, such as local phase congruency, which are invariant to changes in illumination and contrast. We demonstrate that to mitigate for the inherent sensitivity to noise of the local phase congruency measure, the nonlinear coding mechanisms of the fly photoreceptors are tuned to suppress random phase signals, which explains why photoreceptor responses to naturalistic stimuli are significantly different from their responses to white noise stimuli. PMID:27336733

Stellar Wakes from Dark Matter Subhalos

NASA Astrophysics Data System (ADS)

Buschmann, Malte; Kopp, Joachim; Safdi, Benjamin R.; Wu, Chih-Liang

2018-05-01

We propose a novel method utilizing stellar kinematic data to detect low-mass substructure in the Milky Way's dark matter halo. By probing characteristic wakes that a passing dark matter subhalo leaves in the phase-space distribution of ambient halo stars, we estimate sensitivities down to subhalo masses of ˜107 M⊙ or below. The detection of such subhalos would have implications for dark matter and cosmological models that predict modifications to the halo-mass function at low halo masses. We develop an analytic formalism for describing the perturbed stellar phase-space distributions, and we demonstrate through idealized simulations the ability to detect subhalos using the phase-space model and a likelihood framework. Our method complements existing methods for low-mass subhalo searches, such as searches for gaps in stellar streams, in that we can localize the positions and velocities of the subhalos today.

Continuous-wave THz vector imaging system utilizing two-tone signal generation and self-mixing detection.

PubMed

Song, Hajun; Hwang, Sejin; An, Hongsung; Song, Ho-Jin; Song, Jong-In

2017-08-21

We propose and demonstrate a continuous-wave vector THz imaging system utilizing a photonic generation of two-tone THz signals and self-mixing detection. The proposed system measures amplitude and phase information simultaneously without the local oscillator reference or phase rotation scheme that is required for heterodyne or homodyne detection. In addition, 2π phase ambiguity that occurs when the sample is thicker than the wavelength of THz radiation can be avoided. In this work, THz signal having two frequency components was generated with a uni-traveling-carrier photodiode and electro-optic modulator on the emitter side and detected with a Schottky barrier diode detector used as a self-mixer on the receiver side. The proposed THz vector imaging system exhibited a 50-dB signal to noise ratio and 0.012-rad phase fluctuation with 100-μs integration time at 325-GHz. With the system, we demonstrate two-dimensional THz phase contrast imaging. Considering the recent use of two-dimensional arrays of Schottky barrier diodes as a THz image sensor, the proposed system is greatly advantageous for realizing a real-time THz vector imaging system due to its simple receiver configuration.

Detecting many-body-localization lengths with cold atoms

NASA Astrophysics Data System (ADS)

Guo, Xuefei; Li, Xiaopeng

2018-03-01

Considering ultracold atoms in optical lattices, we propose experimental protocols to study many-body-localization (MBL) length and criticality in quench dynamics. Through numerical simulations with exact diagonalization, we show that in the MBL phase the perturbed density profile following a local quench remains exponentially localized in postquench dynamics. The size of this density profile after long-time-dynamics defines a localization length, which tends to diverge at the MBL-to-ergodic transition as we increase the system size. The determined localization transition point agrees with previous exact diagonalization calculations using other diagnostics. Our numerical results provide evidence for violation of the Harris-Chayes bound for the MBL criticality. The critical exponent ν can be extracted from our proposed dynamical procedure, which can then be used directly in experiments to determine whether the Harris-Chayes-bound holds for the MBL transition. These proposed protocols to detect localization criticality are justified by benchmarking to the well-established results for the noninteracting three-dimensional Anderson localization.

A Probabilistic Approach to Network Event Formation from Pre-Processed Waveform Data

NASA Astrophysics Data System (ADS)

Kohl, B. C.; Given, J.

2017-12-01

The current state of the art for seismic event detection still largely depends on signal detection at individual sensor stations, including picking accurate arrivals times and correctly identifying phases, and relying on fusion algorithms to associate individual signal detections to form event hypotheses. But increasing computational capability has enabled progress toward the objective of fully utilizing body-wave recordings in an integrated manner to detect events without the necessity of previously recorded ground truth events. In 2011-2012 Leidos (then SAIC) operated a seismic network to monitor activity associated with geothermal field operations in western Nevada. We developed a new association approach for detecting and quantifying events by probabilistically combining pre-processed waveform data to deal with noisy data and clutter at local distance ranges. The ProbDet algorithm maps continuous waveform data into continuous conditional probability traces using a source model (e.g. Brune earthquake or Mueller-Murphy explosion) to map frequency content and an attenuation model to map amplitudes. Event detection and classification is accomplished by combining the conditional probabilities from the entire network using a Bayesian formulation. This approach was successful in producing a high-Pd, low-Pfa automated bulletin for a local network and preliminary tests with regional and teleseismic data show that it has promise for global seismic and nuclear monitoring applications. The approach highlights several features that we believe are essential to achieving low-threshold automated event detection: Minimizes the utilization of individual seismic phase detections - in traditional techniques, errors in signal detection, timing, feature measurement and initial phase ID compound and propagate into errors in event formation, Has a formalized framework that utilizes information from non-detecting stations, Has a formalized framework that utilizes source information, in particular the spectral characteristics of events of interest, Is entirely model-based, i.e. does not rely on a priori's - particularly important for nuclear monitoring, Does not rely on individualized signal detection thresholds - it's the network solution that matters.

Demonstration of Shear Localization in Ultrafine Grained Tungsten Alloys via Powder Metallurgy Processing Route

DTIC Science & Technology

2012-09-01

of a di-tungsten boride (W2B) phase was not detected in the nW-B sample, but the low concentration of boron may have made this phase undetectable by...Split Hopkinson Bar UFG ultrafine grained W2B di-tungsten boride XRD x-ray diffraction NO. OF NO. OF COPIES ORGANIZATION COPIES

An active UHF RFID localization system for fawn saving

NASA Astrophysics Data System (ADS)

Eberhardt, M.; Lehner, M.; Ascher, A.; Allwang, M.; Biebl, E. M.

2015-11-01

We present a localization concept for active UHF RFID transponders which enables mowing machine drivers to detect and localize marked fawns. The whole system design and experimental results with transponders located near the ground in random orientations in a meadow area are shown. The communication flow between reader and transponders is realized as a dynamic master-slave concept. Multiple marked fawns will be localized by processing detected transponders sequentially. With an eight-channel-receiver with integrated calibration method one can estimate the direction-of-arrival by measuring the phases of the transponder signals up to a range of 50 m in all directions. For further troubleshooting array manifolds have been measured. An additional hand-held receiver with a two-channel receiver allows a guided approaching search without endangering the fawn by the mowing machine.

The 2D analytic signal for envelope detection and feature extraction on ultrasound images.

PubMed

Wachinger, Christian; Klein, Tassilo; Navab, Nassir

2012-08-01

The fundamental property of the analytic signal is the split of identity, meaning the separation of qualitative and quantitative information in form of the local phase and the local amplitude, respectively. Especially the structural representation, independent of brightness and contrast, of the local phase is interesting for numerous image processing tasks. Recently, the extension of the analytic signal from 1D to 2D, covering also intrinsic 2D structures, was proposed. We show the advantages of this improved concept on ultrasound RF and B-mode images. Precisely, we use the 2D analytic signal for the envelope detection of RF data. This leads to advantages for the extraction of the information-bearing signal from the modulated carrier wave. We illustrate this, first, by visual assessment of the images, and second, by performing goodness-of-fit tests to a Nakagami distribution, indicating a clear improvement of statistical properties. The evaluation is performed for multiple window sizes and parameter estimation techniques. Finally, we show that the 2D analytic signal allows for an improved estimation of local features on B-mode images. Copyright © 2012 Elsevier B.V. All rights reserved.

Comparison of Pelvic Phased-Array versus Endorectal Coil Magnetic Resonance Imaging at 3 Tesla for Local Staging of Prostate Cancer

PubMed Central

Kim, Bum Soo; Kim, Tae-Hwan; Kwon, Tae Gyun

2012-01-01

Purpose Several studies have demonstrated the superiority of endorectal coil magnetic resonance imaging (MRI) over pelvic phased-array coil MRI at 1.5 Tesla for local staging of prostate cancer. However, few have studied which evaluation is more accurate at 3 Tesla MRI. In this study, we compared the accuracy of local staging of prostate cancer using pelvic phased-array coil or endorectal coil MRI at 3 Tesla. Materials and Methods Between January 2005 and May 2010, 151 patients underwent radical prostatectomy. All patients were evaluated with either pelvic phased-array coil or endorectal coil prostate MRI prior to surgery (63 endorectal coils and 88 pelvic phased-array coils). Tumor stage based on MRI was compared with pathologic stage. We calculated the specificity, sensitivity and accuracy of each group in the evaluation of extracapsular extension and seminal vesicle invasion. Results Both endorectal coil and pelvic phased-array coil MRI achieved high specificity, low sensitivity and moderate accuracy for the detection of extracapsular extension and seminal vesicle invasion. There were statistically no differences in specificity, sensitivity and accuracy between the two groups. Conclusion Overall staging accuracy, sensitivity and specificity were not significantly different between endorectal coil and pelvic phased-array coil MRI. PMID:22476999

Pressure-induced amorphization of YVO₄:Eu³⁺ nanoboxes.

PubMed

Ruiz-Fuertes, J; Gomis, O; León-Luis, S F; Schrodt, N; Manjón, F J; Ray, S; Santamaría-Pérez, D; Sans, J A; Ortiz, H M; Errandonea, D; Ferrer-Roca, C; Segura, A; Martínez-García, D; Lavín, V; Rodríguez-Mendoza, U R; Muñoz, A

2016-01-15

A structural transformation from the zircon-type structure to an amorphous phase has been found in YVO4:Eu(3+) nanoboxes at high pressures above 12.7 GPa by means of x-ray diffraction measurements. However, the pair distribution function of the high-pressure phase shows that the local structure of the amorphous phase is similar to the scheelite-type YVO4. These results are confirmed both by Raman spectroscopy and Eu(3+) photoluminescence which detect the phase transition to a scheelite-type structure at 10.1 and 9.1 GPa, respectively. The irreversibility of the phase transition is observed with the three techniques after a maximum pressure in the upstroke of around 20 GPa. The existence of two (5)D0-->(7)F0 photoluminescence peaks confirms the existence of two local environments for Eu(3+), at least for the low-pressure phase. One environment is the expected for substituting Y(3+) and the other is likely a disordered environment possibly found at the surface of the nanoboxes.

Numerical and experimental simulation of linear shear piezoelectric phased arrays for structural health monitoring

NASA Astrophysics Data System (ADS)

Wang, Wentao; Zhang, Hui; Lynch, Jerome P.; Cesnik, Carlos E. S.; Li, Hui

2017-04-01

A novel d36-type piezoelectric wafer fabricated from lead magnesium niobate-lead titanate (PMN-PT) is explored for the generation of in-plane horizontal shear waves in plate structures. The study focuses on the development of a linear phased array (PA) of PMN-PT wafers to improve the damage detection capabilities of a structural health monitoring (SHM) system. An attractive property of in-plane horizontal shear waves is that they are nondispersive yet sensitive to damage. This study characterizes the directionality of body waves (Lamb and horizontal shear) created by a single PMN-PT wafer bonded to the surface of a metallic plate structure. Second, a linear PA is designed from PMN-PT wafers to steer and focus Lamb and horizontal shear waves in a plate structure. Numerical studies are conducted to explore the capabilities of a PMN-PT-based PA to detect damage in aluminum plates. Numerical simulations are conducted using the Local Interaction Simulation Approach (LISA) implemented on a parallelized graphical processing unit (GPU) for high-speed execution. Numerical studies are further validated using experimental tests conducted with a linear PA. The study confirms the ability of an PMN-PT phased array to accurately detect and localize damage in aluminum plates.

Wilson loop's phase transition probed by non-local observable

NASA Astrophysics Data System (ADS)

Li, Hui-Ling; Feng, Zhong-Wen; Yang, Shu-Zheng; Zu, Xiao-Tao

2018-04-01

In order to give further insights into the holographic Van der Waals phase transition, it would be of great interest to investigate the behavior of Wilson loop across the holographic phase transition for a higher dimensional hairy black hole. We offer a possibility to proceed with a numerical calculation in order to discussion on the hairy black hole's phase transition, and show that Wilson loop can serve as a probe to detect a phase structure of the black hole. Furthermore, for a first order phase transition, we calculate numerically the Maxwell's equal area construction; and for a second order phase transition, we also study the critical exponent in order to characterize the Wilson loop's phase transition.

Accurate polarimeter with multicapture fitting for plastic lens evaluation

NASA Astrophysics Data System (ADS)

Domínguez, Noemí; Mayershofer, Daniel; Garcia, Cristina; Arasa, Josep

2016-02-01

Due to their manufacturing process, plastic injection molded lenses do not achieve a constant density throughout their volume. This change of density introduces tensions in the material, inducing local birefringence, which in turn is translated into a variation of the ordinary and extraordinary refractive indices that can be expressed as a retardation phase plane using the Jones matrix notation. The detection and measurement of the value of the retardation of the phase plane are therefore very useful ways to evaluate the quality of plastic lenses. We introduce a polariscopic device to obtain two-dimensional maps of the tension distribution in the bulk of a lens, based on detection of the local birefringence. In addition to a description of the device and the mathematical approach used, a set of initial measurements is presented that confirms the validity of the developed system for the testing of the uniformity of plastic lenses.

Generating the Local Oscillator "Locally" in Continuous-Variable Quantum Key Distribution Based on Coherent Detection

NASA Astrophysics Data System (ADS)

Qi, Bing; Lougovski, Pavel; Pooser, Raphael; Grice, Warren; Bobrek, Miljko

2015-10-01

Continuous-variable quantum key distribution (CV-QKD) protocols based on coherent detection have been studied extensively in both theory and experiment. In all the existing implementations of CV-QKD, both the quantum signal and the local oscillator (LO) are generated from the same laser and propagate through the insecure quantum channel. This arrangement may open security loopholes and limit the potential applications of CV-QKD. In this paper, we propose and demonstrate a pilot-aided feedforward data recovery scheme that enables reliable coherent detection using a "locally" generated LO. Using two independent commercial laser sources and a spool of 25-km optical fiber, we construct a coherent communication system. The variance of the phase noise introduced by the proposed scheme is measured to be 0.04 (rad2 ), which is small enough to enable secure key distribution. This technology also opens the door for other quantum communication protocols, such as the recently proposed measurement-device-independent CV-QKD, where independent light sources are employed by different users.

Lock-in thermographic inspection of squats on rail steel head

NASA Astrophysics Data System (ADS)

Peng, D.; Jones, R.

2013-03-01

The development of squat defects has become a major concern in numerous railway systems throughout the world. Infrared thermography is a relatively new non-destructive inspection technique used for a wide range of applications. However, it has not been used for rail squat detection. Lock-in thermography is a non-destructive inspection technique that utilizes an infrared camera to detect the thermal waves. A thermal image is produced, which displays the local thermal wave variation in phase or amplitude. In inhomogeneous materials, the amplitude and phase of the thermal wave carries information related to both the local thermal properties and the nature of the structure being inspected. By examining the infrared thermal signature of squat damage on the head of steel rails, it was possible to generate a relationship matching squat depth to thermal image phase angle, using appropriate experimental/numerical calibration. The results showed that with the additional data sets obtained from further experimental tests, the clarity of this relationship will be greatly improved to a level whereby infrared thermal contours can be directly translated into the precise subsurface behaviour of a squat.

Stellar Wakes from Dark Matter Subhalos.

PubMed

Buschmann, Malte; Kopp, Joachim; Safdi, Benjamin R; Wu, Chih-Liang

2018-05-25

We propose a novel method utilizing stellar kinematic data to detect low-mass substructure in the Milky Way's dark matter halo. By probing characteristic wakes that a passing dark matter subhalo leaves in the phase-space distribution of ambient halo stars, we estimate sensitivities down to subhalo masses of ∼10^{7}  M_{⊙} or below. The detection of such subhalos would have implications for dark matter and cosmological models that predict modifications to the halo-mass function at low halo masses. We develop an analytic formalism for describing the perturbed stellar phase-space distributions, and we demonstrate through idealized simulations the ability to detect subhalos using the phase-space model and a likelihood framework. Our method complements existing methods for low-mass subhalo searches, such as searches for gaps in stellar streams, in that we can localize the positions and velocities of the subhalos today.

Characterizing the Atomic Structure in Low Concentrations of Weakly Ordered, Weakly Scattering Materials Using the Pair Distribution Function

NASA Astrophysics Data System (ADS)

Terban, Maxwell W.

Nanoscale structural characterization is critical to understanding the physical underpinnings of properties and behavior in materials with technological applications. The work herein shows how the pair distribution function technique can be applied to x-ray total scattering data for material systems which weakly scatter x-rays, a typically difficult task due to the poor signal-to-noise obtained from the structures of interest. Characterization and structural modeling are demonstrated for a variety of molecular and porous systems, along with the detection and characterization of disordered, minority phases and components. In particular, reliable detection and quantitative analysis are demonstrated for nanocrystals of an active pharmaceutical ingredient suspended in dilute solution down to a concentration of 0.25 wt. %, giving a practical limit of detection for ordered nanoscale phases within a disordered matrix. Further work shows that minority nanocrystalline phases can be detected, fingerprinted, and modeled for mixed crystalline and amorphous systems of small molecules and polymers. The crystallization of amorphous lactose is followed under accelerated aging conditions. Melt quenching is shown to produce a different local structure than spray drying or freeze drying, along with increased resistance to crystallization. The initial phases which form in the spray dried formulation are identified as a mixture of polymorphs different from the final alpha-lactose monohydrate form. Hard domain formation in thermoplastic polyurethanes is also characterized as a function of methylene diphenyl diisocyanate and butanediol component ratio, showing that distinct and different hard phase structures can form and are solved by indexing with structures derived from molecular dynamics relaxation. In both cases, phase fractions can be quantified in the mixed crystalline and amorphous systems by fitting with both standards or structure models. Later chapters, demonstrate pair distribution characterization of particle incorporation, structure, and synthesis of nanoporous materials. Nanoparticle size distributions are extracted from platinum nanoparticles nucleating within a zeolite matrix through structural modeling, and validated by transmission electron microscope studies. The structure of zirconium phosphonate-phosphate unconventional metal organic framework is determined to consist of turbostratically disordered nanocrystalline layers of Zr-phenylphosphonate, and the local environment of terbium intercalated between the layers is found to resemble the local environment in scheelite-type terbium phosphate. Finally, the early stages of reaction between aqueous zinc dinitrate hexahydrate and methanolic 2-methylimidazole are characterized using in situ total scattering measurements, showing that secondary building units of tetrahedrally coordinated by 2-methylimidazole initially form upon reaction. Overall, the methodologies are developed and applied toward phase detection, identification, solution, and behavior in pharmaceuticals, polymers, and nanoporous materials along with advice for carrying out experiments and analysis on such materials such that they can be extended to other similar systems.

Homodyning and heterodyning the quantum phase

NASA Technical Reports Server (NTRS)

Dariano, Giacomo M.; Macchiavello, C.; Paris, M. G. A.

1994-01-01

The double-homodyne and the heterodyne detection schemes for phase shifts between two synchronous modes of the electromagnetic field are analyzed in the framework of quantum estimation theory. The probability operator-valued measures (POM's) of the detectors are evaluated and compared with the ideal one in the limit of strong local reference oscillator. The present operational approach leads to a reasonable definition of phase measurement, whose sensitivity is actually related to the output r.m.s. noise of the photodetector. We emphasize that the simple-homodyne scheme does not correspond to a proper phase-shift measurements as it is just a zero-point detector. The sensitivity of all detection schemes are optimized at fixed energy with respect to the input state of radiation. It is shown that the optimal sensitivity can be actually achieved using suited squeezed states.

Phase-sensitive detection of acoustically stimulated electromagnetic response in steel

NASA Astrophysics Data System (ADS)

Yamada, Hisato; Yotsuji, Junichi; Ikushima, Kenji

2018-07-01

The signal amplitude and the phase of acoustically stimulated electromagnetic (ASEM) response have been investigated in steel. In the ASEM method, magnetization is temporally modulated with the radio frequency (rf) of irradiated ultrasonic waves through magnetomechanical coupling. The first-harmonic components of the induced rf dipolar magnetic fields are detected using a resonant loop antenna. The signal amplitude of ASEM waves is determined by the magnitude of local piezomagnetic coefficients on an acoustically excited spot. Here, we divided the ASEM waves into the “in-phase” and “quadrature” components by phase-sensitive detection (PSD). On the basis of the linear response theory, we provided the theoretical formalism of ASEM response by introducing local complex piezomagnetic coefficients, d loc = d‧ + id‧‧. We investigated the magnetic field (H) dependence of the individual components on the different surface conditions of steel plates. The in-phase component [∝ d‧(H)] shows a hysteresis loop on the machined surface of a steel plate, in which d‧(H) switches sign at two finite field values, ±H 0. The inversion of magnetization associated with the applied static fields is thus definitely observed in the PSD measurements. In addition, we measured the hysteresis behaviors on a steel surface with a thin mill scale (iron oxide layers). The hysteresis loop broadens and a significant contribution of the quadrature component [∝ d‧‧(H)] is found. We discuss the origin of the hysteresis behaviors of d‧ and d‧‧ using the Debye relaxation model.

Pilot-multiplexed continuous-variable quantum key distribution with a real local oscillator

NASA Astrophysics Data System (ADS)

Wang, Tao; Huang, Peng; Zhou, Yingming; Liu, Weiqi; Zeng, Guihua

2018-01-01

We propose a pilot-multiplexed continuous-variable quantum key distribution (CVQKD) scheme based on a local local oscillator (LLO). Our scheme utilizes time-multiplexing and polarization-multiplexing techniques to dramatically isolate the quantum signal from the pilot, employs two heterodyne detectors to separately detect the signal and the pilot, and adopts a phase compensation method to almost eliminate the multifrequency phase jitter. In order to analyze the performance of our scheme, a general LLO noise model is constructed. Besides the phase noise and the modulation noise, the photon-leakage noise from the reference path and the quantization noise due to the analog-to-digital converter (ADC) are also considered, which are first analyzed in the LLO regime. Under such general noise model, our scheme has a higher key rate and longer secure distance compared with the preexisting LLO schemes. Moreover, we also conduct an experiment to verify our pilot-multiplexed scheme. Results show that it maintains a low level of the phase noise and is expected to obtain a 554-Kbps secure key rate within a 15-km distance under the finite-size effect.

Real-time shear velocity imaging using sonoelastographic techniques.

PubMed

Hoyt, Kenneth; Parker, Kevin J; Rubens, Deborah J

2007-07-01

In this paper, a novel sonoelastographic technique for estimating local shear velocities from propagating shear wave interference patterns (termed crawling waves) is introduced. A relationship between the local crawling wave spatial phase derivatives and local shear wave velocity is derived with phase derivatives estimated using an autocorrelation technique. Results from homogeneous phantoms demonstrate the ability of sonoelastographic shear velocity imaging to quantify the true underlying shear velocity distributions as verified using time-of-flight measurements. Heterogeneous phantom results reveal the capacity for lesion detection and shear velocity quantification as validated from mechanical measurements on phantom samples. Experimental results obtained from a prostate specimen illustrated feasibility for shear velocity imaging in tissue. More importantly, high-contrast visualization of focal carcinomas was demonstrated introducing the clinical potential of this novel sonoelastographic imaging technique.

Ferritin L and Ferritin H are differentially located within hepatic and extra hepatic organs under physiological and acute phase conditions.

PubMed

Ahmad, Shakil; Moriconi, Federico; Naz, Naila; Sultan, Sadaf; Sheikh, Nadeem; Ramadori, Giuliano; Malik, Ihtzaz Ahmed

2013-01-01

Ferritin L (FTL) and Ferritin H (FTH) subunits are responsible for intercellular iron storage. We previously reported increasing amounts of liver cytoplasmic and nuclear iron content during acute phase response (APR). Aim of the present study is to demonstrate intracellular localization of ferritin subunits in liver compared with extra hepatic organs of rat under physiological and acute phase conditions. Rats were administered turpentine-oil (TO) intramuscularly to induce a sterile abscess (acute-phase-model) and sacrificed at different time points. Immunohistochemistry was performed utilizing horse-reddish-peroxidise conjugated secondary antibody on 4μm thick section. Liver cytoplasmic and nuclear protein were used for Western blot analysis. By means of immunohistology, FTL was detected in cytoplasm while a strong nuclear positivity for FTH was evident in the liver. Similarly, in heart, spleen and brain FTL was detected mainly in the cytoplasm while FTH demonstrated intense nuclear and a weak cytoplasmic expression. Western blot analysis of cytoplasmic and nuclear fractions from liver, heart, spleen and brain further confirmed mainly cytoplasmic expression of FTL in contrast to the nuclear and cytoplasmic expression of FTH. The data presented demonstrate the differential localization of FTL and FTH within hepatic and extra hepatic organs being FTL predominantly in the cytoplasm while FTH predominantly in nucleus.

Driven Phases of Quantum Matter

NASA Astrophysics Data System (ADS)

Khemani, Vedika; von Keyserlingk, Curt; Lazarides, Achilleas; Moessner, Roderich; Sondhi, Shivaji

Clean and interacting periodically driven quantum systems are believed to exhibit a single, trivial ``infinite-temperature'' Floquet-ergodic phase. By contrast, I will show that their disordered Floquet many-body localized counterparts can exhibit distinct ordered phases with spontaneously broken symmetries delineated by sharp transitions. Some of these are analogs of equilibrium states, while others are genuinely new to the Floquet setting. I will show that a subset of these novel phases are absolutely stableto all weak local deformations of the underlying Floquet drives, and spontaneously break Hamiltonian dependent emergent symmetries. Strikingly, they simultaneously also break the underlying time-translation symmetry of the Floquet drive and the order parameter exhibits oscillations at multiples of the fundamental period. This ``time-crystallinity'' goes hand in hand with spatial symmetry breaking and, altogether, these phases exhibit a novel form of simultaneous long-range order in space and time. I will describe how this spatiotemporal order can be detected in experiments involving quenches from a broad class of initial states.

Localization of multiple defects using the compact phased array (CPA) method

NASA Astrophysics Data System (ADS)

Senyurek, Volkan Y.; Baghalian, Amin; Tashakori, Shervin; McDaniel, Dwayne; Tansel, Ibrahim N.

2018-01-01

Array systems of transducers have found numerous applications in detection and localization of defects in structural health monitoring (SHM) of plate-like structures. Different types of array configurations and analysis algorithms have been used to improve the process of localization of defects. For accurate and reliable monitoring of large structures by array systems, a high number of actuator and sensor elements are often required. In this study, a compact phased array system consisting of only three piezoelectric elements is used in conjunction with an updated total focusing method (TFM) for localization of single and multiple defects in an aluminum plate. The accuracy of the localization process was greatly improved by including wave propagation information in TFM. Results indicated that the proposed CPA approach can locate single and multiple defects with high accuracy while decreasing the processing costs and the number of required transducers. This method can be utilized in critical applications such as aerospace structures where the use of a large number of transducers is not desirable.

Quantum localization and bound-state formation in Bose-Einstein condensates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Franzosi, Roberto; Giampaolo, Salvatore M.; Illuminati, Fabrizio

2010-12-15

We discuss the possibility of exponential quantum localization in systems of ultracold bosonic atoms with repulsive interactions in open optical lattices without disorder. We show that exponential localization occurs in the maximally excited state of the lowest energy band. We establish the conditions under which the presence of the upper energy bands can be neglected, determine the successive stages and the quantum phase boundaries at which localization occurs, and discuss schemes to detect it experimentally by visibility measurements. The discussed mechanism is a particular type of quantum localization that is intuitively understood in terms of the interplay between nonlinearity andmore » a bounded energy spectrum.« less

Enhanced backscatter of optical beams reflected in turbulent air.

PubMed

Nelson, W; Palastro, J P; Wu, C; Davis, C C

2015-07-01

Optical beams propagating through air acquire phase distortions from turbulent fluctuations in the refractive index. While these distortions are usually deleterious to propagation, beams reflected in a turbulent medium can undergo a local recovery of spatial coherence and intensity enhancement referred to as enhanced backscatter (EBS). Here we validate the commonly used phase screen simulation with experimental results obtained from lab-scale experiments. We also verify theoretical predictions of the dependence of the turbulence strength on EBS. Finally, we present a novel algorithm called the "tilt-shift method" which allows detection of EBS in frozen turbulence, reducing the time required to detect the EBS signal.

Alternating phase-shifting masks: phase determination and impact of quartz defects--theoretical and experimental results

NASA Astrophysics Data System (ADS)

Griesinger, Uwe A.; Dettmann, Wolfgang; Hennig, Mario; Heumann, Jan P.; Koehle, Roderick; Ludwig, Ralf; Verbeek, Martin; Zarrabian, Mardjan

2002-07-01

In optical lithography balancing the aerial image of an alternating phase shifting mask (alt. PSM) is a major challenge. For the exposure wavelengths (currently 248nm and 193nm) an optimum etching method is necessary to overcome imbalance effects. Defects play an important role in the imbalances of the aerial image. In this contribution defects will be discussed by using the methodology of global phase imbalance control also for local imbalances which are a result of quartz defects. The effective phase error can be determined with an AIMS-system by measuring the CD width between the images of deep- and shallow trenches at different focus settings. The AIMS results are analyzed in comparison to the simulated and lithographic print results of the alternating structures. For the analysis of local aerial image imbalances it is necessary to investigate the capability of detecting these phase defects with state of the art inspection systems. Alternating PSMs containing programmed defects were inspected with different algorithms to investigate the capture rate of special phase defects in dependence on the defect size. Besides inspection also repair of phase defects is an important task. In this contribution we show the effect of repair on the optical behavior of phase defects. Due to the limited accuracy of the repair tools the repaired area still shows a certain local phase error. This error can be caused either by residual quartz material or a substrate damage. The influence of such repair induced phase errors on the aerial image were investigated.

Automatic bone outer contour extraction from B-modes ultrasound images based on local phase symmetry and quadratic polynomial fitting

NASA Astrophysics Data System (ADS)

Karlita, Tita; Yuniarno, Eko Mulyanto; Purnama, I. Ketut Eddy; Purnomo, Mauridhi Hery

2017-06-01

Analyzing ultrasound (US) images to get the shapes and structures of particular anatomical regions is an interesting field of study since US imaging is a non-invasive method to capture internal structures of a human body. However, bone segmentation of US images is still challenging because it is strongly influenced by speckle noises and it has poor image quality. This paper proposes a combination of local phase symmetry and quadratic polynomial fitting methods to extract bone outer contour (BOC) from two dimensional (2D) B-modes US image as initial steps of three-dimensional (3D) bone surface reconstruction. By using local phase symmetry, the bone is initially extracted from US images. BOC is then extracted by scanning one pixel on the bone boundary in each column of the US images using first phase features searching method. Quadratic polynomial fitting is utilized to refine and estimate the pixel location that fails to be detected during the extraction process. Hole filling method is then applied by utilize the polynomial coefficients to fill the gaps with new pixel. The proposed method is able to estimate the new pixel position and ensures smoothness and continuity of the contour path. Evaluations are done using cow and goat bones by comparing the resulted BOCs with the contours produced by manual segmentation and contours produced by canny edge detection. The evaluation shows that our proposed methods produces an excellent result with average MSE before and after hole filling at the value of 0.65.

Sensing Floquet-Majorana fermions via heat transfer

NASA Astrophysics Data System (ADS)

Molignini, Paolo; van Nieuwenburg, Evert; Chitra, R.

2017-09-01

Time periodic modulations of the transverse field in the closed X Y spin-1/2 chain generate a very rich dynamical phase diagram, with a hierarchy of Zn topological phases characterized by differing numbers of Floquet-Majorana modes. This rich phase diagram survives when the system is coupled to dissipative end reservoirs. Circumventing the obstacle of preparing and measuring quasienergy configurations endemic to Floquet-Majorana detection schemes, we show that stroboscopic heat transport and spin density are robust observables to detect both the dynamical phase transitions and Majorana modes in dissipative settings. We find that the heat current provides very clear signatures of these Floquet topological phase transitions. In particular, we observe that the derivative of the heat current, with respect to a control parameter, changes sign at the boundaries separating topological phases with differing nonzero numbers of Floquet-Majorana modes. We present a simple scheme to directly count the number of Floquet-Majorana modes in a phase from the Fourier transform of the local spin density profile. Our results are valid provided the anisotropies are not strong and can be easily implemented in quantum engineered systems.

Corona Phase Molecular Recognition (CoPhMoRe) to Enable New Nanosensor Interfaces

NASA Astrophysics Data System (ADS)

Strano, Michael

2015-03-01

Our lab at MIT has been interested in how the 1D and 2D electronic structures of carbon nanotubes and graphene respectively can be utilized to advance new concepts in molecular detection. We introduce CoPhMoRe or corona phase molecular recognition as a method of discovering synthetic antibodies, or nanotube-templated recognition sites from a heteropolymer library. We show that certain synthetic heteropolymers, once constrained onto a single-walled carbon nanotube by chemical adsorption, also form a new corona phase that exhibits highly selective recognition for specific molecules. To prove the generality of this phenomenon, we report three examples of heteropolymers-nanotube recognition complexes for riboflavin, L-thyroxine and estradiol. The platform opens new opportunities to create synthetic recognition sites for molecular detection. We have also extended this molecular recognition technique to neurotransmitters, producing the first fluorescent sensor for dopamine. Another area of advancement in biosensor development is the use of near infrared fluorescent carbon nanotube sensors for in-vivo detection. Here, we show that PEG-ligated d(AAAT)7 DNA wrapped SWNT are selective for nitric oxide, a vasodilator of blood vessels, and can be tail vein injected into mice and localized within the viable mouse liver. We use an SJL mouse model to study liver inflammation in vivo using the spatially and spectrally resolved nIR signature of the localized SWNT sensors.

Performance on Tests of Central Auditory Processing by Individuals Exposed to High-Intensity Blasts

DTIC Science & Technology

2012-07-01

percent (gap detected on at least four of the six presentations), with all longer durations receiving a score greater than 50 percent. Binaural ...Processing and Sound Localization Temporal precision of neural firing is also involved in binaural processing and localization of sound in space. The...Masking Level Difference (MLD) test evaluates the integrity of the earliest sites of binaural comparison and sensitivity to interaural phase in the

Shear wave pulse compression for dynamic elastography using phase-sensitive optical coherence tomography

NASA Astrophysics Data System (ADS)

Nguyen, Thu-Mai; Song, Shaozhen; Arnal, Bastien; Wong, Emily Y.; Huang, Zhihong; Wang, Ruikang K.; O'Donnell, Matthew

2014-01-01

Assessing the biomechanical properties of soft tissue provides clinically valuable information to supplement conventional structural imaging. In the previous studies, we introduced a dynamic elastography technique based on phase-sensitive optical coherence tomography (PhS-OCT) to characterize submillimetric structures such as skin layers or ocular tissues. Here, we propose to implement a pulse compression technique for shear wave elastography. We performed shear wave pulse compression in tissue-mimicking phantoms. Using a mechanical actuator to generate broadband frequency-modulated vibrations (1 to 5 kHz), induced displacements were detected at an equivalent frame rate of 47 kHz using a PhS-OCT. The recorded signal was digitally compressed to a broadband pulse. Stiffness maps were then reconstructed from spatially localized estimates of the local shear wave speed. We demonstrate that a simple pulse compression scheme can increase shear wave detection signal-to-noise ratio (>12 dB gain) and reduce artifacts in reconstructing stiffness maps of heterogeneous media.

Evaluation of Food Freshness and Locality by Odor Sensor

NASA Astrophysics Data System (ADS)

Koike, Takayuki; Shimada, Koji; Kamimura, Hironobu; Kaneki, Noriaki

The aim of this study was to investigate whether food freshness and locality can be classified using a food evaluation system consisting four SnO2-semiconductor gas sensors and a solid phase column, into which collecting aroma materials. The temperature of sensors was periodically changed to be in unsteady state and thus, the sensor information was increased. The parameters (in quefrency band) were extracted from sensor information using cepstrum analysis that enable to separate superimposed information on sinusoidal wave. The quefrency was used as parameters for principal component and discriminant analyses (PCA and DCA) to detect food freshness and food localities. We used three kinds of strawberries, people can perceive its odors, passed from one to three days after harvest, and kelps and Ceylon tea, people are hardly to perceive its odor, corrected from five areas as sample. Then, the deterioration of strawberries and localities of kelps and Ceylon teas were visually evaluated using the numerical analyses. While the deteriorations were classified using PCA or DCA, the localities were classified only by DCA. The findings indicate that, although odorant intensity influenced the method detecting food quality, the quefrency obtained from odorant information using cepstrum analysis were available to detect the difference in the freshness and the localities of foods.

PATL: A RFID Tag Localization based on Phased Array Antenna.

PubMed

Qiu, Lanxin; Liang, Xiaoxuan; Huang, Zhangqin

2017-03-15

In RFID systems, how to detect the position precisely is an important and challenging research topic. In this paper, we propose a range-free 2D tag localization method based on phased array antenna, called PATL. This method takes advantage of the adjustable radiation angle of the phased array antenna to scan the surveillance region in turns. By using the statistics of the tags' number in different antenna beam directions, a weighting algorithm is used to calculate the position of the tag. This method can be applied to real-time location of multiple targets without usage of any reference tags or additional readers. Additionally, we present an optimized weighting method based on RSSI to increase the locating accuracy. We use a Commercial Off-the-Shelf (COTS) UHF RFID reader which is integrated with a phased array antenna to evaluate our method. The experiment results from an indoor office environment demonstrate the average distance error of PATL is about 21 cm and the optimized approach achieves an accuracy of 13 cm. This novel 2D localization scheme is a simple, yet promising, solution that is especially applicable to the smart shelf visualized management in storage or retail area.

PATL: A RFID Tag Localization based on Phased Array Antenna

PubMed Central

Qiu, Lanxin; Liang, Xiaoxuan; Huang, Zhangqin

2017-01-01

In RFID systems, how to detect the position precisely is an important and challenging research topic. In this paper, we propose a range-free 2D tag localization method based on phased array antenna, called PATL. This method takes advantage of the adjustable radiation angle of the phased array antenna to scan the surveillance region in turns. By using the statistics of the tags’ number in different antenna beam directions, a weighting algorithm is used to calculate the position of the tag. This method can be applied to real-time location of multiple targets without usage of any reference tags or additional readers. Additionally, we present an optimized weighting method based on RSSI to increase the locating accuracy. We use a Commercial Off-the-Shelf (COTS) UHF RFID reader which is integrated with a phased array antenna to evaluate our method. The experiment results from an indoor office environment demonstrate the average distance error of PATL is about 21 cm and the optimized approach achieves an accuracy of 13 cm. This novel 2D localization scheme is a simple, yet promising, solution that is especially applicable to the smart shelf visualized management in storage or retail area. PMID:28295014

Detection and localization capability of an urban seismic sinkhole monitoring network

NASA Astrophysics Data System (ADS)

Becker, Dirk; Dahm, Torsten; Schneider, Fabian

2017-04-01

Microseismic events linked to underground processes in sinkhole areas might serve as precursors to larger mass dislocation or rupture events which can cause felt ground shaking or even structural damage. To identify these weak and shallow events, a sensitive local seismic monitoring network is needed. In case of an urban environment the performance of local monitoring networks is severely compromised by the high anthropogenic noise level. We study the detection and localization capability of such a network, which is already partly installed in the urban area of the city of Hamburg, Germany, within the joint project SIMULTAN (http://www.gfz-potsdam.de/en/section/near-surface-geophysics/projects/simultan/). SIMULTAN aims to monitor a known sinkhole structure and gain a better understanding of the underlying processes. The current network consists of six surface stations installed in the basement of private houses and underground structures of a research facility (DESY - Deutsches Elektronen Synchrotron). During the started monitoring campaign since 2015, no microseismic events could be unambiguously attributed to the sinkholes. To estimate the detection and location capability of the network, we calculate synthetic waveforms based on the location and mechanism of former events in the area. These waveforms are combined with the recorded urban seismic noise at the station sites. As detection algorithms a simple STA/LTA trigger and a more sophisticated phase detector are used. While the STA/LTA detector delivers stable results and is able to detect events with a moment magnitude as low as 0.35 at a distance of 1.3km from the source even under the present high noise conditions the phase detector is more sensitive but also less stable. It should be stressed that due to the local near surface conditions of the wave propagation the detections are generally performed on S- or surface waves and not on P-waves, which have a significantly lower amplitude. Due to the often emergent onsets of the seismic phases of sinkhole events and the high noise conditions the localization capability of the network is assessed by a stacking approach of characteristic waveforms (STA/LTA traces) in addition to traditional estimates based on travel time uncertainties and network geometry. Also the effect of a vertical array of borehole sensors as well as a small scale surface array on the location accuracy is investigated. Due to the expected, rather low frequency character of the seismic signals arrays with a small aperture due to the required close proximity to the source exhibit considerable uncertainty in the determination of the azimuth of the incoming wavefront, but can contribute to better constrain the event location. Future borehole stations, apart from significantly reducing the detection threshold, would also significantly reduce the location uncertainty. In addition, the synthetic data sets created for this study can also be used to better constrain the magnitudes of the microseismic events by deriving attenuation relations for the surface waves of shallow events encountered in the sinkhole environment. This work has been funded by the German 'Geotechnologien' project SIMULTAN (BMBF03G0737A).

Future Directions for the Early Detection of Colorectal Cancer Recurrence

PubMed Central

Walker, Avery S.; Johnson, Eric K.; Maykel, Justin A.; Stojadinovic, Alex; Nissan, Aviram; Brucher, Bjorn; Champagne, Bradley J.; Steele, Scott R.

2014-01-01

Surgical resection remains a mainstay of treatment and is highly effective for localized colorectal cancer. However, ~30-40% of patients develop recurrence following surgery and 40-50% of recurrences are apparent within the first few years after initial surgical resection. Several variables factor into the ultimate outcome of these patients, including the extent of disease, tumor biology, and patient co-morbidities. Additionally, the time from initial treatment to the development of recurrence is strongly associated with overall survival, particularly in patients who recur within one year of their surgical resection. Current post-resection surveillance strategies involve physical examination, laboratory, endoscopic and imaging studies utilizing various high and low-intensity protocols. Ultimately, the goal is to detect recurrence as early as possible, and ideally in the asymptomatic localized phase, to allow initiation of treatment that may still result in cure. While current strategies have been effective, several efforts are evolving to improve our ability to identify recurrent disease at its earliest phase. Our aim with this article is to briefly review the options available and, more importantly, examine emerging and future options to assist in the early detection of colon and rectal cancer recurrence. PMID:24790655

Quantitative evaluation of phase processing approaches in susceptibility weighted imaging

NASA Astrophysics Data System (ADS)

Li, Ningzhi; Wang, Wen-Tung; Sati, Pascal; Pham, Dzung L.; Butman, John A.

2012-03-01

Susceptibility weighted imaging (SWI) takes advantage of the local variation in susceptibility between different tissues to enable highly detailed visualization of the cerebral venous system and sensitive detection of intracranial hemorrhages. Thus, it has been increasingly used in magnetic resonance imaging studies of traumatic brain injury as well as other intracranial pathologies. In SWI, magnitude information is combined with phase information to enhance the susceptibility induced image contrast. Because of global susceptibility variations across the image, the rate of phase accumulation varies widely across the image resulting in phase wrapping artifacts that interfere with the local assessment of phase variation. Homodyne filtering is a common approach to eliminate this global phase variation. However, filter size requires careful selection in order to preserve image contrast and avoid errors resulting from residual phase wraps. An alternative approach is to apply phase unwrapping prior to high pass filtering. A suitable phase unwrapping algorithm guarantees no residual phase wraps but additional computational steps are required. In this work, we quantitatively evaluate these two phase processing approaches on both simulated and real data using different filters and cutoff frequencies. Our analysis leads to an improved understanding of the relationship between phase wraps, susceptibility effects, and acquisition parameters. Although homodyne filtering approaches are faster and more straightforward, phase unwrapping approaches perform more accurately in a wider variety of acquisition scenarios.

Automated macromolecular crystal detection system and method

DOEpatents

Christian, Allen T [Tracy, CA; Segelke, Brent [San Ramon, CA; Rupp, Bernard [Livermore, CA; Toppani, Dominique [Fontainebleau, FR

2007-06-05

An automated macromolecular method and system for detecting crystals in two-dimensional images, such as light microscopy images obtained from an array of crystallization screens. Edges are detected from the images by identifying local maxima of a phase congruency-based function associated with each image. The detected edges are segmented into discrete line segments, which are subsequently geometrically evaluated with respect to each other to identify any crystal-like qualities such as, for example, parallel lines, facing each other, similarity in length, and relative proximity. And from the evaluation a determination is made as to whether crystals are present in each image.

High-dimensional atom localization via spontaneously generated coherence in a microwave-driven atomic system.

PubMed

Wang, Zhiping; Chen, Jinyu; Yu, Benli

2017-02-20

We investigate the two-dimensional (2D) and three-dimensional (3D) atom localization behaviors via spontaneously generated coherence in a microwave-driven four-level atomic system. Owing to the space-dependent atom-field interaction, it is found that the detecting probability and precision of 2D and 3D atom localization behaviors can be significantly improved via adjusting the system parameters, the phase, amplitude, and initial population distribution. Interestingly, the atom can be localized in volumes that are substantially smaller than a cubic optical wavelength. Our scheme opens a promising way to achieve high-precision and high-efficiency atom localization, which provides some potential applications in high-dimensional atom nanolithography.

RF-subcarrier-assisted four-state continuous-variable QKD based on coherent detection.

PubMed

Qu, Zhen; Djordjevic, Ivan B; Neifeld, Mark A

2016-12-01

We theoretically investigate and experimentally demonstrate a RF-assisted four-state continuous-variable quantum key distribution (CV-QKD) system. Classical coherent detection is implemented with a simple digital phase noise cancelation scheme. In the proposed system, there is no need for frequency and phase locking between the quantum signals and the local oscillator laser. Moreover, in principle, there is no residual phase noise, and a mean excess noise of 0.0115 (in shot-noise units) can be acquired experimentally. In addition, the minimum transmittance of 0.45 is reached experimentally for secure transmission with commercial photodetectors, and the maximum secret key rate (SKR) of >12  Mbit/s can be obtained. The proposed RF-assisted CV-QKD system opens the door of incorporating microwave photonics into a CV-QKD system and improving the SKR significantly.

Design of a delayed XOR phase detector for an optical phase-locked loop toward high-speed coherent laser communication.

PubMed

Liu, Yang; Tong, Shoufeng; Chang, Shuai; Song, Yansong; Dong, Yan; Zhao, Xin; An, Zhe; Yu, Fuwan

2018-05-10

Optical phase-locked loops are an effective detection method in high-speed and long-distance laser communication. Although this method can detect weak signal light and maintain a small bit error rate, it is difficult to perform because identifying the phase difference between the signal light and the local oscillator accurately has always been a technical challenge. Thus, a series of studies is conducted to address this issue. First, a delayed exclusive or gate (XOR) phase detector with multi-level loop compound control is proposed. Then, a 50 ps delay line and relative signal-to-noise ratio control at 15 dB are produced through theoretical derivation and simulation. Thereafter, a phase discrimination module is designed on a 15  cm×5  cm printed circuit board board. Finally, the experiment platform is built for verification. Experimental results show that the phase discrimination range is -1.1 to 1.1 GHz, and the gain is 0.82 mV/MHz. Three times the standard deviation, that is, 0.064 V, is observed between the test and theoretical values. The accuracy of phase detection is better than 0.07 V, which meets the design standards. A coherent carrier recovery test system is established. The delayed XOR gate has good performance in this system. When the communication rate is 5 Gbps, the system realizes a bit error rate of 1.55×10 -8 when the optical power of the signal is -40.4  dBm. When the communication rate is increased to 10 Gbps, the detection sensitivity drops to -39.5  dBm and still shows good performance in high-speed communications. This work provides a reference for future high-speed coherent homodyne detection in space. Ideas for the next phase of this study are presented at the end of this paper.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elmagarmid, A.K.

The availability of distributed data bases is directly affected by the timely detection and resolution of deadlocks. Consequently, mechanisms are needed to make deadlock detection algorithms resilient to failures. Presented first is a centralized algorithm that allows transactions to have multiple requests outstanding. Next, a new distributed deadlock detection algorithm (DDDA) is presented, using a global detector (GD) to detect global deadlocks and local detectors (LDs) to detect local deadlocks. This algorithm essentially identifies transaction-resource interactions that m cause global (multisite) deadlocks. Third, a deadlock detection algorithm utilizing a transaction-wait-for (TWF) graph is presented. It is a fully disjoint algorithmmore » that allows multiple outstanding requests. The proposed algorithm can achieve improved overall performance by using multiple disjoint controllers coupled with the two-phase property while maintaining the simplicity of centralized schemes. Fourth, an algorithm that combines deadlock detection and avoidance is given. This algorithm uses concurrent transaction controllers and resource coordinators to achieve maximum distribution. The language of CSP is used to describe this algorithm. Finally, two efficient deadlock resolution protocols are given along with some guidelines to be used in choosing a transaction for abortion.« less

Extended slow dynamical regime close to the many-body localization transition

NASA Astrophysics Data System (ADS)

Luitz, David J.; Laflorencie, Nicolas; Alet, Fabien

2016-02-01

Many-body localization is characterized by a slow logarithmic growth of the entanglement entropy after a global quantum quench while the local memory of an initial density imbalance remains at infinite time. We investigate how much the proximity of a many-body localized phase can influence the dynamics in the delocalized ergodic regime where thermalization is expected. Using an exact Krylov space technique, the out-of-equilibrium dynamics of the random-field Heisenberg chain is studied up to L =28 sites, starting from an initially unentangled high-energy product state. Within most of the delocalized phase, we find a sub-ballistic entanglement growth S (t ) ∝t1 /z with a disorder-dependent exponent z ≥1 , in contrast with the pure ballistic growth z =1 of clean systems. At the same time, anomalous relaxation is also observed for the spin imbalance I (t ) ∝t-ζ with a continuously varying disorder-dependent exponent ζ , vanishing at the transition. This provides a clear experimental signature for detecting this nonconventional regime.

Synchronization Tomography: Modeling and Exploring Complex Brain Dynamics

NASA Astrophysics Data System (ADS)

Fieseler, Thomas

2002-03-01

Phase synchronization (PS) plays an important role both under physiological and pathological conditions. With standard averaging techniques of MEG data, it is difficult to reliably detect cortico-cortical and cortico-muscular PS processes that are not time-locked to an external stimulus. For this reason, novel synchronization analysis techniques were developed and directly applied to MEG signals. Of course, due to the lack of an inverse modeling (i.e. source localization), the spatial resolution of this approach was limited. To detect and localize cerebral PS, we here present the synchronization tomography (ST): For this, we first estimate the cerebral current source density by means of the magnetic field tomography (MFT). We then apply the single-run PS analysis to the current source density in each voxel of the reconstruction space. In this way we study simulated PS, voxel by voxel in order to determine the spatio-temporal resolution of the ST. To this end different generators of ongoing rhythmic cerebral activity are simulated by current dipoles at different locations and directions, which are modeled by slightly detuned chaotic oscillators. MEG signals for these generators are simulated for a spherical head model and a whole-head MEG system. MFT current density solutions are calculated from these simulated signals within a hemispherical source space. We compare the spatial resolution of the ST with that of the MFT. Our results show that adjacent sources which are indistinguishable for the MFT, can nevertheless be separated with the ST, provided they are not strongly phase synchronized. This clearly demonstrates the potential of combining spatial information (i.e. source localization) with temporal information for the anatomical localization of phase synchronization in the human brain.

Scheme for efficient extraction of low-frequency signal beyond the quantum limit by frequency-shift detection.

PubMed

Yang, R G; Zhang, J; Zhai, Z H; Zhai, S Q; Liu, K; Gao, J R

2015-08-10

Low-frequency (Hz~kHz) squeezing is very important in many schemes of quantum precision measurement. But it is more difficult than that at megahertz-frequency because of the introduction of laser low-frequency technical noise. In this paper, we propose a scheme to obtain a low-frequency signal beyond the quantum limit from the frequency comb in a non-degenerate frequency and degenerate polarization optical parametric amplifier (NOPA) operating below threshold with type I phase matching by frequency-shift detection. Low-frequency squeezing immune to laser technical noise is obtained by a detection system with a local beam of two-frequency intense laser. Furthermore, the low-frequency squeezing can be used for phase measurement in Mach-Zehnder interferometer, and the signal-to-noise ratio (SNR) can be enhanced greatly.

Parametric imaging of experimentally simulated Wolff-Parkinson-White syndrome conduction abnormalities in dogs: a concise communication

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weismueller, P.H.; Henze, E.; Adam, W.E.

1986-01-01

In order to test the diagnostic potential of phase analysis of radionuclide ventriculography (RNV) for localizing accessory bundles in Wolff-Parkinson-White (WPW) syndrome, 24 experimental runs were performed in three open chest instrumented dogs. After a baseline study, WPW syndrome was simulated by stimulation at seven different sites around the base of the ventricles, and RNV's were obtained. Subsequent data processing including Fourier transformation allowed the localization of the site of the first inward motion of the ventricles by an isophasic wave display. In sinus rhythm, the septum contracted first. During ectopic premature ventricular stimulation by triggering the atrial signal, themore » phase scan was altered only when the stimulus was applied earlier than 20 ms before the expected QRS complex during sinus rhythm. During stimulation with fixed frequency, only the left lateral positions of the premature stimulation were detected by phase analysis with a sensitivity of 86%. Neither the antero- or posteroseptal nor the right ventricular premature contraction pattern could be exactly localized.« less

Optically Phase-Locked Electronic Speckle Pattern Interferometer (OPL-ESPI)

NASA Astrophysics Data System (ADS)

Moran, Steven E.; Law, Robert L.; Craig, Peter N.; Goldberg, Warren M.

1986-10-01

This report describes the design, theory, operation, and characteristics of the OPL-ESPI, which generates real time equal Doppler speckle contours of vibrating objects from unstable sensor platforms with a Doppler resolution of 30 Hz and a maximum tracking range of + or - 5 HMz. The optical phase locked loop compensates for the deleterious effects of ambient background vibration and provides the bases for a new ESPI video signal processing technique, which produces high contrast speckle contours. The OPL-ESPI system has local oscillator phase modulation capability, offering the potential for detection of vibrations with the amplitudes less than lambda/100.

MR-based detection of individual histotripsy bubble clouds formed in tissues and phantoms.

PubMed

Allen, Steven P; Hernandez-Garcia, Luis; Cain, Charles A; Hall, Timothy L

2016-11-01

To demonstrate that MR sequences can detect individual histotripsy bubble clouds formed inside intact tissues. A line-scan and an EPI sequence were sensitized to histotripsy by inserting a bipolar gradient whose lobes bracketed the lifespan of a histotripsy bubble cloud. Using a 7 Tesla, small-bore scanner, these sequences monitored histotripsy clouds formed in an agar phantom and in vitro porcine liver and brain. The bipolar gradients were adjusted to apply phase with k-space frequencies of 10, 300 or 400 cm -1 . Acoustic pressure amplitude was also varied. Cavitation was simultaneously monitored using a passive cavitation detection system. Each image captured local signal loss specific to an individual bubble cloud. In the agar phantom, this signal loss appeared only when the transducer output exceeded the cavitation threshold pressure. In tissues, bubble clouds were immediately detected when the gradients created phase with k-space frequencies of 300 and 400 cm -1 . When the gradients created phase with a k-space frequency of 10 cm -1 , individual bubble clouds were not detectable until many acoustic pulses had been applied to the tissue. Cavitation-sensitive MR-sequences can detect single histotripsy bubble clouds formed in biologic tissue. Detection is influenced by the sensitizing gradients and treatment history. Magn Reson Med 76:1486-1493, 2016. © 2015 International Society for Magnetic Resonance in Medicine. © 2015 International Society for Magnetic Resonance in Medicine.

Enhanced Ultrasound Visualization of Brachytherapy Seeds by a Novel Magnetically Induced Motion Imaging Method

DTIC Science & Technology

2007-04-01

We report our progress in developing Magnetically Induced Motion Imaging (MIMI) for unambiguous identification and localization brachytherapy seeds ...tail artifacts in segmented seed images. The second is a method for joining ends of seeds in segmented seed images based on the phase of the detected

Cumulative phase delay imaging for contrast-enhanced ultrasound tomography

NASA Astrophysics Data System (ADS)

Demi, Libertario; van Sloun, Ruud J. G.; Wijkstra, Hessel; Mischi, Massimo

2015-11-01

Standard dynamic-contrast enhanced ultrasound (DCE-US) imaging detects and estimates ultrasound-contrast-agent (UCA) concentration based on the amplitude of the nonlinear (harmonic) components generated during ultrasound (US) propagation through UCAs. However, harmonic components generation is not specific to UCAs, as it also occurs for US propagating through tissue. Moreover, nonlinear artifacts affect standard DCE-US imaging, causing contrast to tissue ratio reduction, and resulting in possible misclassification of tissue and misinterpretation of UCA concentration. Furthermore, no contrast-specific modality exists for DCE-US tomography; in particular speed-of-sound changes due to UCAs are well within those caused by different tissue types. Recently, a new marker for UCAs has been introduced. A cumulative phase delay (CPD) between the second harmonic and fundamental component is in fact observable for US propagating through UCAs, and is absent in tissue. In this paper, tomographic US images based on CPD are for the first time presented and compared to speed-of-sound US tomography. Results show the applicability of this marker for contrast specific US imaging, with cumulative phase delay imaging (CPDI) showing superior capabilities in detecting and localizing UCA, as compared to speed-of-sound US tomography. Cavities (filled with UCA) which were down to 1 mm in diameter were clearly detectable. Moreover, CPDI is free of the above mentioned nonlinear artifacts. These results open important possibilities to DCE-US tomography, with potential applications to breast imaging for cancer localization.

Cumulative phase delay imaging for contrast-enhanced ultrasound tomography.

PubMed

Demi, Libertario; van Sloun, Ruud J G; Wijkstra, Hessel; Mischi, Massimo

2015-11-07

Standard dynamic-contrast enhanced ultrasound (DCE-US) imaging detects and estimates ultrasound-contrast-agent (UCA) concentration based on the amplitude of the nonlinear (harmonic) components generated during ultrasound (US) propagation through UCAs. However, harmonic components generation is not specific to UCAs, as it also occurs for US propagating through tissue. Moreover, nonlinear artifacts affect standard DCE-US imaging, causing contrast to tissue ratio reduction, and resulting in possible misclassification of tissue and misinterpretation of UCA concentration. Furthermore, no contrast-specific modality exists for DCE-US tomography; in particular speed-of-sound changes due to UCAs are well within those caused by different tissue types. Recently, a new marker for UCAs has been introduced. A cumulative phase delay (CPD) between the second harmonic and fundamental component is in fact observable for US propagating through UCAs, and is absent in tissue. In this paper, tomographic US images based on CPD are for the first time presented and compared to speed-of-sound US tomography. Results show the applicability of this marker for contrast specific US imaging, with cumulative phase delay imaging (CPDI) showing superior capabilities in detecting and localizing UCA, as compared to speed-of-sound US tomography. Cavities (filled with UCA) which were down to 1 mm in diameter were clearly detectable. Moreover, CPDI is free of the above mentioned nonlinear artifacts. These results open important possibilities to DCE-US tomography, with potential applications to breast imaging for cancer localization.

String order parameters for one-dimensional Floquet symmetry protected topological phases

NASA Astrophysics Data System (ADS)

Kumar, Ajesh; Dumitrescu, Philipp T.; Potter, Andrew C.

2018-06-01

Floquet symmetry protected topological (FSPT) phases are nonequilibrium topological phases enabled by time-periodic driving. FSPT phases of one-dimensional (1D) chains of bosons, spins, or qubits host dynamically protected edge states that can store quantum information without decoherence, making them promising for use as quantum memories. While FSPT order cannot be detected by any local measurement, here we construct nonlocal string order parameters that directly measure general 1D FSPT order. We propose a superconducting-qubit array based realization of the simplest Ising FSPT phase, which can be implemented with existing quantum computing hardware. We devise an interferometric scheme to directly measure the nonlocal string order using only simple one- and two-qubit operations and single-qubit measurements.

Automatic detection and recognition of signs from natural scenes.

PubMed

Chen, Xilin; Yang, Jie; Zhang, Jing; Waibel, Alex

2004-01-01

In this paper, we present an approach to automatic detection and recognition of signs from natural scenes, and its application to a sign translation task. The proposed approach embeds multiresolution and multiscale edge detection, adaptive searching, color analysis, and affine rectification in a hierarchical framework for sign detection, with different emphases at each phase to handle the text in different sizes, orientations, color distributions and backgrounds. We use affine rectification to recover deformation of the text regions caused by an inappropriate camera view angle. The procedure can significantly improve text detection rate and optical character recognition (OCR) accuracy. Instead of using binary information for OCR, we extract features from an intensity image directly. We propose a local intensity normalization method to effectively handle lighting variations, followed by a Gabor transform to obtain local features, and finally a linear discriminant analysis (LDA) method for feature selection. We have applied the approach in developing a Chinese sign translation system, which can automatically detect and recognize Chinese signs as input from a camera, and translate the recognized text into English.

Performance of synchronous optical receivers using atmospheric compensation techniques.

PubMed

Belmonte, Aniceto; Khan, Joseph

2008-09-01

We model the impact of atmospheric turbulence-induced phase and amplitude fluctuations on free-space optical links using synchronous detection. We derive exact expressions for the probability density function of the signal-to-noise ratio in the presence of turbulence. We consider the effects of log-normal amplitude fluctuations and Gaussian phase fluctuations, in addition to local oscillator shot noise, for both passive receivers and those employing active modal compensation of wave-front phase distortion. We compute error probabilities for M-ary phase-shift keying, and evaluate the impact of various parameters, including the ratio of receiver aperture diameter to the wave-front coherence diameter, and the number of modes compensated.

Noise Analysis of Simultaneous Quantum Key Distribution and Classical Communication Scheme Using a True Local Oscillator

DOE PAGES

Qi, Bing; Lim, Charles Ci Wen

2018-05-07

Recently, we proposed a simultaneous quantum and classical communication (SQCC) protocol where random numbers for quantum key distribution and bits for classical communication are encoded on the same weak coherent pulse and decoded by the same coherent receiver. Such a scheme could be appealing in practice since a single coherent communication system can be used for multiple purposes. However, previous studies show that the SQCC protocol can tolerate only very small phase noise. This makes it incompatible with the coherent communication scheme using a true local oscillator (LO), which presents a relatively high phase noise due to the fact thatmore » the signal and the LO are generated from two independent lasers. We improve the phase noise tolerance of the SQCC scheme using a true LO by adopting a refined noise model where phase noises originating from different sources are treated differently: on the one hand, phase noise associated with the coherent receiver may be regarded as trusted noise since the detector can be calibrated locally and the photon statistics of the detected signals can be determined from the measurement results; on the other hand, phase noise due to the instability of fiber interferometers may be regarded as untrusted noise since its randomness (from the adversary’s point of view) is hard to justify. Simulation results show the tolerable phase noise in this refined noise model is significantly higher than that in the previous study, where all of the phase noises are assumed to be untrusted. In conclusion, we conduct an experiment to show that the required phase stability can be achieved in a coherent communication system using a true LO.« less

Noise Analysis of Simultaneous Quantum Key Distribution and Classical Communication Scheme Using a True Local Oscillator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qi, Bing; Lim, Charles Ci Wen

Recently, we proposed a simultaneous quantum and classical communication (SQCC) protocol where random numbers for quantum key distribution and bits for classical communication are encoded on the same weak coherent pulse and decoded by the same coherent receiver. Such a scheme could be appealing in practice since a single coherent communication system can be used for multiple purposes. However, previous studies show that the SQCC protocol can tolerate only very small phase noise. This makes it incompatible with the coherent communication scheme using a true local oscillator (LO), which presents a relatively high phase noise due to the fact thatmore » the signal and the LO are generated from two independent lasers. We improve the phase noise tolerance of the SQCC scheme using a true LO by adopting a refined noise model where phase noises originating from different sources are treated differently: on the one hand, phase noise associated with the coherent receiver may be regarded as trusted noise since the detector can be calibrated locally and the photon statistics of the detected signals can be determined from the measurement results; on the other hand, phase noise due to the instability of fiber interferometers may be regarded as untrusted noise since its randomness (from the adversary’s point of view) is hard to justify. Simulation results show the tolerable phase noise in this refined noise model is significantly higher than that in the previous study, where all of the phase noises are assumed to be untrusted. In conclusion, we conduct an experiment to show that the required phase stability can be achieved in a coherent communication system using a true LO.« less

Noise Analysis of Simultaneous Quantum Key Distribution and Classical Communication Scheme Using a True Local Oscillator

NASA Astrophysics Data System (ADS)

Qi, Bing; Lim, Charles Ci Wen

2018-05-01

Recently, we proposed a simultaneous quantum and classical communication (SQCC) protocol where random numbers for quantum key distribution and bits for classical communication are encoded on the same weak coherent pulse and decoded by the same coherent receiver. Such a scheme could be appealing in practice since a single coherent communication system can be used for multiple purposes. However, previous studies show that the SQCC protocol can tolerate only very small phase noise. This makes it incompatible with the coherent communication scheme using a true local oscillator (LO), which presents a relatively high phase noise due to the fact that the signal and the LO are generated from two independent lasers. We improve the phase noise tolerance of the SQCC scheme using a true LO by adopting a refined noise model where phase noises originating from different sources are treated differently: on the one hand, phase noise associated with the coherent receiver may be regarded as trusted noise since the detector can be calibrated locally and the photon statistics of the detected signals can be determined from the measurement results; on the other hand, phase noise due to the instability of fiber interferometers may be regarded as untrusted noise since its randomness (from the adversary's point of view) is hard to justify. Simulation results show the tolerable phase noise in this refined noise model is significantly higher than that in the previous study, where all of the phase noises are assumed to be untrusted. We conduct an experiment to show that the required phase stability can be achieved in a coherent communication system using a true LO.

Localization and molecular forms of galanin in human adrenals: elevated levels in pheochromocytomas.

PubMed

Bauer, F E; Hacker, G W; Terenghi, G; Adrian, T E; Polak, J M; Bloom, S R

1986-12-01

Galanin immunoreactivity was measured by RIA, using antibodies directed against both the non-C- and C-terminal positions of porcine galanin, in tissue extracts of normal adrenals and pheochromocytomas and also in the plasma of normal subjects and patients with pheochromocytomas. No C-terminal galanin-like immunoreactivity was detected in plasma or tissue, suggesting differences in the amino acid sequence of human compared with porcine galanin. A non-C-terminally directed antibody was, therefore, used to characterize human galanin immunoreactivity by gel permeation chromatography and reverse phase high pressure liquid chromatography and to localize it by immunocytochemistry. The galanin content of whole adrenal gland was 2.6 +/- 0.9 (+/- SEM) pmol/g (n = 5). In contrast, however, pheochromocytomas had much greater concentrations (21 +/- 2.3 pmol/g; n = 16). Gel chromatography and reverse phase high pressure liquid chromatography revealed 2 molecular forms of galanin immunoreactivity with identical elution positions in both normal adrenals and tumors. The concentration of galanin in plasma from both normal subjects and pheochromocytoma patients was below the detection limit of the assay (less than 10 pmol/liter). Using immunocytochemistry, galanin was localized to scattered cells or clusters of tumor cells in 5 of 11 pheochromocytomas and only a few chromaffin cells and cortical nerve fibers in normal adrenals.

Edge detection based on adaptive threshold b-spline wavelet for optical sub-aperture measuring

NASA Astrophysics Data System (ADS)

Zhang, Shiqi; Hui, Mei; Liu, Ming; Zhao, Zhu; Dong, Liquan; Liu, Xiaohua; Zhao, Yuejin

2015-08-01

In the research of optical synthetic aperture imaging system, phase congruency is the main problem and it is necessary to detect sub-aperture phase. The edge of the sub-aperture system is more complex than that in the traditional optical imaging system. And with the existence of steep slope for large-aperture optical component, interference fringe may be quite dense when interference imaging. Deep phase gradient may cause a loss of phase information. Therefore, it's urgent to search for an efficient edge detection method. Wavelet analysis as a powerful tool is widely used in the fields of image processing. Based on its properties of multi-scale transform, edge region is detected with high precision in small scale. Longing with the increase of scale, noise is reduced in contrary. So it has a certain suppression effect on noise. Otherwise, adaptive threshold method which sets different thresholds in various regions can detect edge points from noise. Firstly, fringe pattern is obtained and cubic b-spline wavelet is adopted as the smoothing function. After the multi-scale wavelet decomposition of the whole image, we figure out the local modulus maxima in gradient directions. However, it also contains noise, and thus adaptive threshold method is used to select the modulus maxima. The point which greater than threshold value is boundary point. Finally, we use corrosion and expansion deal with the resulting image to get the consecutive boundary of image.

Device-Free Localization via an Extreme Learning Machine with Parameterized Geometrical Feature Extraction.

PubMed

Zhang, Jie; Xiao, Wendong; Zhang, Sen; Huang, Shoudong

2017-04-17

Device-free localization (DFL) is becoming one of the new technologies in wireless localization field, due to its advantage that the target to be localized does not need to be attached to any electronic device. In the radio-frequency (RF) DFL system, radio transmitters (RTs) and radio receivers (RXs) are used to sense the target collaboratively, and the location of the target can be estimated by fusing the changes of the received signal strength (RSS) measurements associated with the wireless links. In this paper, we will propose an extreme learning machine (ELM) approach for DFL, to improve the efficiency and the accuracy of the localization algorithm. Different from the conventional machine learning approaches for wireless localization, in which the above differential RSS measurements are trivially used as the only input features, we introduce the parameterized geometrical representation for an affected link, which consists of its geometrical intercepts and differential RSS measurement. Parameterized geometrical feature extraction (PGFE) is performed for the affected links and the features are used as the inputs of ELM. The proposed PGFE-ELM for DFL is trained in the offline phase and performed for real-time localization in the online phase, where the estimated location of the target is obtained through the created ELM. PGFE-ELM has the advantages that the affected links used by ELM in the online phase can be different from those used for training in the offline phase, and can be more robust to deal with the uncertain combination of the detectable wireless links. Experimental results show that the proposed PGFE-ELM can improve the localization accuracy and learning speed significantly compared with a number of the existing machine learning and DFL approaches, including the weighted K-nearest neighbor (WKNN), support vector machine (SVM), back propagation neural network (BPNN), as well as the well-known radio tomographic imaging (RTI) DFL approach.

Device-Free Localization via an Extreme Learning Machine with Parameterized Geometrical Feature Extraction

PubMed Central

Zhang, Jie; Xiao, Wendong; Zhang, Sen; Huang, Shoudong

2017-01-01

Device-free localization (DFL) is becoming one of the new technologies in wireless localization field, due to its advantage that the target to be localized does not need to be attached to any electronic device. In the radio-frequency (RF) DFL system, radio transmitters (RTs) and radio receivers (RXs) are used to sense the target collaboratively, and the location of the target can be estimated by fusing the changes of the received signal strength (RSS) measurements associated with the wireless links. In this paper, we will propose an extreme learning machine (ELM) approach for DFL, to improve the efficiency and the accuracy of the localization algorithm. Different from the conventional machine learning approaches for wireless localization, in which the above differential RSS measurements are trivially used as the only input features, we introduce the parameterized geometrical representation for an affected link, which consists of its geometrical intercepts and differential RSS measurement. Parameterized geometrical feature extraction (PGFE) is performed for the affected links and the features are used as the inputs of ELM. The proposed PGFE-ELM for DFL is trained in the offline phase and performed for real-time localization in the online phase, where the estimated location of the target is obtained through the created ELM. PGFE-ELM has the advantages that the affected links used by ELM in the online phase can be different from those used for training in the offline phase, and can be more robust to deal with the uncertain combination of the detectable wireless links. Experimental results show that the proposed PGFE-ELM can improve the localization accuracy and learning speed significantly compared with a number of the existing machine learning and DFL approaches, including the weighted K-nearest neighbor (WKNN), support vector machine (SVM), back propagation neural network (BPNN), as well as the well-known radio tomographic imaging (RTI) DFL approach. PMID:28420187

Performance evaluation and optimization of multiband phase-modulated radio over IsOWC link with balanced coherent homodyne detection

NASA Astrophysics Data System (ADS)

Zong, Kang; Zhu, Jiang

2018-04-01

In this paper, we present a multiband phase-modulated (PM) radio over intersatellite optical wireless communication (IsOWC) link with balanced coherent homodyne detection. The proposed system can provide the transparent transport of multiband radio frequency (RF) signals with higher linearity and better receiver sensitivity than intensity modulated with direct detection (IM/DD) system. The expressions of RF gain, noise figure (NF) and third-order spurious-free dynamic range (SFDR) are derived considering the third-order intermodulation product and amplifier spontaneous emission (ASE) noise. The optimal power of local oscillator (LO) optical signal is also derived theoretically. Numerical results for RF gain, NF and third-order SFDR are given for demonstration. Results indicate that the gain of the optical preamplifier and the power of LO optical signal should be optimized to obtain the satisfactory performance.

Facilitating Follow-up of LIGO-Virgo Events Using Rapid Sky Localization

NASA Astrophysics Data System (ADS)

Chen, Hsin-Yu; Holz, Daniel E.

2017-05-01

We discuss an algorithm for accurate and very low-latency (<1 s) localization of gravitational-wave (GW) sources using only the relative times of arrival, relative phases, and relative signal-to-noise ratios for pairs of detectors. The algorithm is independent of distances and masses to leading order, and can be generalized to all discrete (as opposed to stochastic and continuous) sources detected by ground-based detector networks. Our approach is similar to that of BAYESTAR with a few modifications, which result in increased computational efficiency. For the LIGO two-detector configuration (Hanford+Livingston) operating in O1 we find a median 50% (90%) localization of 143 deg2 (558 deg2) for binary neutron stars. We use our algorithm to explore the improvement in localization resulting from loud events, finding that the loudest out of the first 4 (or 10) events reduces the median sky-localization area by a factor of 1.9 (3.0) for the case of two GW detectors, and 2.2 (4.0) for three detectors. We also consider the case of multi-messenger joint detections in both the gravitational and the electromagnetic radiation, and show that joint localization can offer significant improvements (e.g., in the case of LIGO and Fermi/GBM joint detections). We show that a prior on the binary inclination, potentially arising from GRB observations, has a negligible effect on GW localization. Our algorithm is simple, fast, and accurate, and may be of particular utility in the development of multi-messenger astronomy.

Spatial Analysis for Monitoring Forest Health

Treesearch

Francis A. Roesch

1994-01-01

A plan for the spatial analysis for the sample design for the detection monitoring phase in the joint USDA Forest Service/EPA Forest Health Monitoring Program (FHM) in the United States is discussed. The spatial analysis procedure is intended to more quickly identify changes in forest health by providing increased sensitivity to localized changes. The procedure is...

Multi-Dimensional Scaling based grouping of known complexes and intelligent protein complex detection.

PubMed

Rehman, Zia Ur; Idris, Adnan; Khan, Asifullah

2018-06-01

Protein-Protein Interactions (PPI) play a vital role in cellular processes and are formed because of thousands of interactions among proteins. Advancements in proteomics technologies have resulted in huge PPI datasets that need to be systematically analyzed. Protein complexes are the locally dense regions in PPI networks, which extend important role in metabolic pathways and gene regulation. In this work, a novel two-phase protein complex detection and grouping mechanism is proposed. In the first phase, topological and biological features are extracted for each complex, and prediction performance is investigated using Bagging based Ensemble classifier (PCD-BEns). Performance evaluation through cross validation shows improvement in comparison to CDIP, MCode, CFinder and PLSMC methods Second phase employs Multi-Dimensional Scaling (MDS) for the grouping of known complexes by exploring inter complex relations. It is experimentally observed that the combination of topological and biological features in the proposed approach has greatly enhanced prediction performance for protein complex detection, which may help to understand various biological processes, whereas application of MDS based exploration may assist in grouping potentially similar complexes. Copyright © 2018 Elsevier Ltd. All rights reserved.

Quantum tomography enhanced through parametric amplification

NASA Astrophysics Data System (ADS)

Knyazev, E.; Spasibko, K. Yu; Chekhova, M. V.; Khalili, F. Ya

2018-01-01

Quantum tomography is the standard method of reconstructing the Wigner function of quantum states of light by means of balanced homodyne detection. The reconstruction quality strongly depends on the photodetectors quantum efficiency and other losses in the measurement setup. In this article we analyze in detail a protocol of enhanced quantum tomography, proposed by Leonhardt and Paul [1] which allows one to reduce the degrading effect of detection losses. It is based on phase-sensitive parametric amplification, with the phase of the amplified quadrature being scanned synchronously with the local oscillator phase. Although with sufficiently strong amplification the protocol enables overcoming any detection inefficiency, it was so far not implemented in the experiment, probably due to the losses in the amplifier. Here we discuss a possible proof-of-principle experiment with a traveling-wave parametric amplifier. We show that with the state-of-the-art optical elements, the protocol enables high fidelity tomographic reconstruction of bright non-classical states of light. We consider two examples: bright squeezed vacuum and squeezed single-photon state, with the latter being a non-Gaussian state and both strongly affected by the losses.

Design of an Fiber-Coupled Laser Heterodyne Interferometer for the FLARE

NASA Astrophysics Data System (ADS)

Frank, Samuel; Yoo, Jongsoo; Ji, Hantao; Jara-Almonte, Jon

2016-10-01

The FLARE (Facility for Laboratory Reconnection Experiments), which is currently under construction at PPPL, requires a complete set of laboratory plasma diagnostics. The Langmuir probes that will be used in the device to gather local density data require a reliable interferometer system to serve as baseline for density measurement calibration. A fully fiber-coupled infrared laser heterodyne interferometer has been designed in order to serve as the primary line-integrated electron density diagnostic. Thanks to advances in the communications industry many fiber optic devices and phase detection methods have advanced significantly becoming increasingly reliable and inexpensive. Fully fiber coupling a plasma interferometer greatly simplifies alignment procedures needed since the only free space laser path needing alignment is through the plasma itself. Fiber-coupling also provides significant resistance to vibrational noise, a common problem in plasma interferometry systems. This device also uses a greatly simplified phase detection scheme in which chips, originally developed for the communications industry, capable of directly detecting the phase shift of a signal with high time resolution. The design and initial performance of the system will be discussed.

Community detection in networks with unequal groups.

PubMed

Zhang, Pan; Moore, Cristopher; Newman, M E J

2016-01-01

Recently, a phase transition has been discovered in the network community detection problem below which no algorithm can tell which nodes belong to which communities with success any better than a random guess. This result has, however, so far been limited to the case where the communities have the same size or the same average degree. Here we consider the case where the sizes or average degrees differ. This asymmetry allows us to assign nodes to communities with better-than-random success by examining their local neighborhoods. Using the cavity method, we show that this removes the detectability transition completely for networks with four groups or fewer, while for more than four groups the transition persists up to a critical amount of asymmetry but not beyond. The critical point in the latter case coincides with the point at which local information percolates, causing a global transition from a less-accurate solution to a more-accurate one.

In situ optimization of pH for parts-per-billion electrochemical detection of dissolved hydrogen sulfide using boron doped diamond flow electrodes.

PubMed

Bitziou, Eleni; Joseph, Maxim B; Read, Tania L; Palmer, Nicola; Mollart, Tim; Newton, Mark E; Macpherson, Julie V

2014-11-04

A novel electrochemical approach to the direct detection of hydrogen sulfide (H2S), in aqueous solutions, covering a wide pH range (acid to alkali), is described. In brief, a dual band electrode device is employed, in a hydrodynamic flow cell, where the upstream electrode is used to controllably generate hydroxide ions (OH(-)), which flood the downstream detector electrode and provide the correct pH environment for complete conversion of H2S to the electrochemically detectable, sulfide (HS(-)) ion. All-diamond, coplanar conducting diamond band electrodes, insulated in diamond, were used due to their exceptional stability and robustness when applying extreme potentials, essential attributes for both local OH(-) generation via the reduction of water, and for in situ cleaning of the electrode, post oxidation of sulfide. Using a galvanostatic approach, it was demonstrated the pH locally could be modified by over five pH units, depending on the initial pH of the mobile phase and the applied current. Electrochemical detection limits of 13.6 ppb sulfide were achieved using flow injection amperometry. This approach which offers local control of the pH of the detector electrode in a solution, which is far from ideal for optimized detection of the analyte of interest, enhances the capabilities of online electrochemical detection systems.

Generating the local oscillator "locally" in continuous-variable quantum key distribution based on coherent detection

DOE PAGES

Qi, Bing; Lougovski, Pavel; Pooser, Raphael C.; ...

2015-10-21

Continuous-variable quantum key distribution (CV-QKD) protocols based on coherent detection have been studied extensively in both theory and experiment. In all the existing implementations of CV-QKD, both the quantum signal and the local oscillator (LO) are generated from the same laser and propagate through the insecure quantum channel. This arrangement may open security loopholes and limit the potential applications of CV-QKD. In our paper, we propose and demonstrate a pilot-aided feedforward data recovery scheme that enables reliable coherent detection using a “locally” generated LO. Using two independent commercial laser sources and a spool of 25-km optical fiber, we construct amore » coherent communication system. The variance of the phase noise introduced by the proposed scheme is measured to be 0.04 (rad 2), which is small enough to enable secure key distribution. This technology opens the door for other quantum communication protocols, such as the recently proposed measurement-device-independent CV-QKD, where independent light sources are employed by different users.« less

Vertically Integrated Seismological Analysis I : Modeling

NASA Astrophysics Data System (ADS)

Russell, S.; Arora, N. S.; Jordan, M. I.; Sudderth, E.

2009-12-01

As part of its CTBT verification efforts, the International Data Centre (IDC) analyzes seismic and other signals collected from hundreds of stations around the world. Current processing at the IDC proceeds in a series of pipelined stages. From station processing to network processing, each decision is made on the basis of local information. This has the advantage of efficiency, and simplifies the structure of software implementations. However, this approach may reduce accuracy in the detection and phase classification of arrivals, association of detections to hypothesized events, and localization of small-magnitude events.In our work, we approach such detection and association problems as ones of probabilistic inference. In simple terms, let X be a random variable ranging over all possible collections of events, with each event defined by time, location, magnitude, and type (natural or man-made). Let Y range over all possible waveform signal recordings at all detection stations. Then Pθ(X) describes a parameterized generative prior over events, and P[|#30#|]φ(Y | X) describes how the signal is propagated and measured (including travel time, selective absorption and scattering, noise, artifacts, sensor bias, sensor failures, etc.). Given observed recordings Y = y, we are interested in the posterior P(X | Y = y), and perhaps in the value of X that maximizes it—i.e., the most likely explanation for all the sensor readings. As detailed below, an additional focus of our work is to robustly learn appropriate model parameters θ and φ from historical data. The primary advantage we expect is that decisions about arrivals, phase classifications, and associations are made with the benefit of all available evidence, not just the local signal or predefined recipes. Important phenomena—such as the successful detection of sub-threshold signals, correction of phase classifications using arrival information at other stations, and removal of false events based on the absence of signals—should all fall out of our probabilistic framework without the need for special processing rules. In our baseline model, natural events occur according to a spatially inhomogeneous Poisson process. Complex events (swarms and aftershocks) may then be captured via temporally inhomogeneous extensions. Man-made events have a uniform probability of occurring anywhere on the earth, with a tendency to occur closer to the surface. Phases are modelled via their amplitude, frequency distribution, and origin. In the simplest case, transmission times are characterized via the one-dimensional IASPEI-91 model, accounting for model errors with Gaussian uncertainty. Such homogeneous, approximate physical models can be further refined via historical data and previously developed corrections. Signal measurements are captured by station-specific models, based on sensor types and geometries, local frequency absorption characteristics, and time-varying noise models. At the conference, we expect to be able to quantitatively demonstrate the advantages of our approach, at least for simulated data. When reporting their findings, such systems can easily flag low-confidence events, unexplained arrivals, and ambiguous classifications to focus the efforts of expert analysts.

Microwave oscillator with reduced phase noise by negative feedback incorporating microwave signals with suppressed carrier

NASA Technical Reports Server (NTRS)

Dick, G. J.; Saunders, J.

1989-01-01

Oscillator configurations which reduce the effect of 1/f noise sources for both direct feedback and stabilized local oscillator (STALO) circuits are developed and analyzed. By appropriate use of carrier suppression, a small signal is generated which suffers no loss of loop phase information or signal-to-noise ratio. This small signal can be amplified without degradation by multiplicative amplifier noise, and can be detected without saturation of the detector. Together with recent advances in microwave resonator Qs, these circuit improvements will make possible lower phase noise than can be presently achieved without the use of cryogenic devices.

'Direct' Gas-Phase Metallicities, Stellar Properties, and Local Environments of Emission-Line Galaxies at Redshifts Below 0.90

NASA Technical Reports Server (NTRS)

Ly, Chun; Malkan, Matthew A.; Nagao, Tohru; Kashikawa, Nobunari; Shimasaku, Kazuhiro; Hayashi, Masao

2013-01-01

Using deep narrow-band (NB) imaging and optical spectroscopy from the Keck telescope and the Multi Mirror Telescope (MMT), we identify a sample of 20 emission-line galaxies (ELGs) at z = 0.065-0.90 where the weak auroral emission line, [O iii] lambda4363, is detected at >=3sigma. These detections allow us to determine the gas-phase metallicity using the "direct" method. With electron temperature measurements, and dust attenuation corrections from Balmer decrements, we find that 4 of these low-mass galaxies are extremely metal-poor with 12+log(O/H) <= 7.65 or one-tenth solar. Our most metal-deficient galaxy has 12+log(O/H)= 7.24(+0.45 / -0.30) (95% confidence), similar to some of the lowest metallicity galaxies identified in the local universe. We find that our galaxies are all undergoing significant star formation with average specific star formation rate (SFR) of (100 Myra)(exp -1), and that they have high central SFR surface densities (average of 0.5 Solar M / yr/ sq. kpc). In addition, more than two-thirds of our galaxies have between one and four nearby companions within a projected radius of 100 kpc, which we find is an excess among star-forming galaxies at z =0.4 -- 0.85. We also find that the gas-phase metallicities for a given stellar mass and SFR lie systematically lower than the local stellar M-Z-(SFR) relation by approx. = 0.2 dex (2 sigma significance). These results are partly due to selection effects, since galaxies with strong star formation and low metallicity are more likely to yield [O iii] lambda4363 detections. Finally, the observed higher ionization parameter and high electron density suggest that they are lower redshift analogs to typical z approx. > 1 galaxies.

Analysis of Sir2E in the cellular slime mold Dictyostelium discoideum: cellular localization, spatial expression and overexpression.

PubMed

Katayama, Takahiro; Yasukawa, Hiro

2008-10-01

It has been reported that Dictyostelium discoideum encodes four silent information regulator 2 (Sir2) proteins (Sir2A-D) showing sequence similarity to human homologues of Sir2 (SIRT1-3). Further screening in a database revealed that D. discoideum encodes an additional Sir2 homologue (Sir2E). The amino acid sequence of Sir2E is not similar to those of SIRTs but is similar to those of proteins encoded by Giardia lamblia, Cryptosporidium hominis and Cryptosporidium parvum. Fluorescence of Sir2E-green fluorescent protein fusion protein was detected in the D. discoideum nucleus, indicating that Sir2E is a nuclear localizing protein. Reverse transcription-polymerase chain reaction and whole-mount in situ hybridization analyses showed that D. discoideum expressed sir2E in amoebae in the growth phase and in prestalk cells in the developmental phase. D. discoideum overexpressing sir2E grew faster than the wild type. These results indicate that Sir2E plays important roles both in the growth phase and developmental phase of D. discoideum.

Enlightening intracellular complexity of living cells with quantitative phase microscopy

NASA Astrophysics Data System (ADS)

Martinez Torres, C.; Laperrousaz, B.; Berguiga, L.; Boyer Provera, E.; Elezgaray, J.; Nicolini, F. E.; Maguer-Satta, V.; Arneodo, A.; Argoul, F.

2016-03-01

The internal distribution of refractive indices (RIs) of a living cell is much more complex than usually admitted in multi-shell models. The reconstruction of RI maps from single phase images has rarely been achieved for several reasons: (i) we still have very little knowledge of the impact of internal macromolecular complexes on the local RI and (ii) phase changes produced by light propagation through the sample are mixed with diffraction effects by internal cell bodies. We propose the implementation a 2D wavelet-based contour chain detection method to distinguish internal boundaries thanks to their greatest optical path difference gradients. These contour chains correspond to the highest image phase contrast and follow the local RI inhomogeneities linked to the intracellular structural intricacy. Their statistics and spatial distribution are morphological indicators for distinguishing cells of different origins and to follow their transformation in pathologic situations. We use this method to compare non adherent blood cells from primary and laboratory culture origins, in healthy and pathological situations (chronic myelogenous leukaemia). In a second part of this presentation, we concentrate on the temporal dynamics of the phase contour chains and we discuss the spectral decomposition of their dynamics in both health and disease.

Deciphering the internal complexity of living cells with quantitative phase microscopy: a multiscale approach

NASA Astrophysics Data System (ADS)

Martinez-Torres, Cristina; Laperrousaz, Bastien; Berguiga, Lotfi; Boyer-Provera, Elise; Elezgaray, Juan; Nicolini, Franck E.; Maguer-Satta, Veronique; Arneodo, Alain; Argoul, Françoise

2015-09-01

The distribution of refractive indices (RIs) of a living cell contributes in a nonintuitive manner to its optical phase image and quite rarely can be inverted to recover its internal structure. The interpretation of the quantitative phase images of living cells remains a difficult task because (1) we still have very little knowledge on the impact of its internal macromolecular complexes on the local RI and (2) phase changes produced by light propagation through the sample are mixed with diffraction effects by the internal cell bodies. We propose to implement a two-dimensional wavelet-based contour chain detection method to distinguish internal boundaries based on their greatest optical path difference gradients. These contour chains correspond to the highest image phase contrast and follow the local RI inhomogeneities linked to the intracellular structural intricacy. Their statistics and spatial distribution are the morphological indicators suited for comparing cells of different origins and/or to follow their transformation in pathologic situations. We use this method to compare nonadherent blood cells from primary and laboratory culture origins and to assess the internal transformation of hematopoietic stem cells by the transduction of the BCR-ABL oncogene responsible for the chronic myelogenous leukemia.

Measuring local volume fraction, long-wavelength correlations, and fractionation in a phase-separating polydisperse fluid

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williamson, J. J., E-mail: johnjosephwilliamson@gmail.com; Evans, R. M. L.

We dynamically simulate fractionation (partitioning of particle species) during spinodal gas-liquid separation of a size-polydisperse colloid, using polydispersity up to ∼40% and a skewed parent size distribution. We introduce a novel coarse-grained Voronoi method to minimise size bias in measuring local volume fraction, along with a variety of spatial correlation functions which detect fractionation without requiring a clear distinction between the phases. These can be applied whether or not a system is phase separated, to determine structural correlations in particle size, and generalise easily to other kinds of polydispersity (charge, shape, etc.). We measure fractionation in both mean size andmore » polydispersity between the phases, its direction differing between model interaction potentials which are identical in the monodisperse case. These qualitative features are predicted by a perturbative theory requiring only a monodisperse reference as input. The results show that intricate fractionation takes place almost from the start of phase separation, so can play a role even in nonequilibrium arrested states. The methods for characterisation of inhomogeneous polydisperse systems could in principle be applied to experiment as well as modelling.« less

Topology-driven phase transitions in the classical monomer-dimer-loop model.

PubMed

Li, Sazi; Li, Wei; Chen, Ziyu

2015-06-01

In this work, we investigate the classical loop models doped with monomers and dimers on a square lattice, whose partition function can be expressed as a tensor network (TN). In the thermodynamic limit, we use the boundary matrix product state technique to contract the partition function TN, and determine the thermodynamic properties with high accuracy. In this monomer-dimer-loop model, we find a second-order phase transition between a trivial monomer-condensation and a loop-condensation (LC) phase, which cannot be distinguished by any local order parameter, while nevertheless the two phases have distinct topological properties. In the LC phase, we find two degenerate dominating eigenvalues in the transfer-matrix spectrum, as well as a nonvanishing (nonlocal) string order parameter, both of which identify the topological ergodicity breaking in the LC phase and can serve as the order parameter for detecting the phase transitions.

Dual-phase (18)F-fluorocholine PET/CT to detect locoregional recurrence of prostate cancer: comparison between each time point of imaging and a summation scan.

PubMed

Tong, Aaron Kian Ti; Zhang, Zoe Xiaozhu; Zaheer, Sumbul; Yan, Xuexian Sean

2016-01-01

Prostate carcinoma is a major health problem, and routine imaging shows only modest results in detecting and restaging clinically localized prostate cancer recurrence. Recent studies have shown promise of radiolabeled analogues of choline for positron emission tomography (PET) scans in patients of biochemical recurrence and that sequentially incremental Fluorocholine (FCH) uptake is associated with malignancy, whereas decreasing tracer activity suggests a benign aetiology. However, this pattern of tracer uptake has not been fully validated, and no standardized (18)F-Fluorocholine ((18)F-FCH) scan protocol is in place yet. This study aimed to better define the role of dual-phase (18)F-FCH PET/computed tomography (CT) imaging using retrospective masked reading focusing on detection of locoregional recurrence/metastasis in patients with biochemical failure after definitive local primary treatment. A total of 32 subjects were enrolled during the period 04/2010 to 05/2014 with histologically proven prostate cancer that was treated with curative intent and had biochemical recurrence. Early scans and delayed imaging of the pelvis were graded separately by blinded readers. Final evaluation using the combination of information from dual-phase studies as a "summation scan" was also performed. Maximum standardized uptake value was computed using regions of interest constructed over focal hyperactivity. Calculations were performed using Statistical Product and Service Solutions, Version 20 for Windows. A composite reference consisting of histopathology, correlation with other imaging, or serum prostate specific antigen (PSA) trend with clinical follow-up of at least 6months was used to determine the true disease status of the patient. Early-phase pelvis imaging sensitivity and specificity were calculated to be 73.1% and 90.9%, respectively. Late-phase pelvis imaging sensitivity and specificity were 80.8% and 100%, respectively. Summation scan sensitivity and specificity were 76.9% and 100%, respectively. The odds ratio of having recurrent disease with an uptrend of SUVmax on dual-phase imaging was 33.3. The optimal cutoff value of PSA was 1.85ng/mL with 80% sensitivity and 62.5% specificity. Single late-phase FCH PET/CT imaging is a reliable scan modality which can detect sites of disease at low levels of PSA which still fulfil the criteria of biochemical recurrence. This will allow clinicians to identify sites for potential biopsy or start locoregional treatment. Copyright © 2016 Elsevier Inc. All rights reserved.

Research on the strategy of underwater united detection fusion and communication using multi-sensor

NASA Astrophysics Data System (ADS)

Xu, Zhenhua; Huang, Jianguo; Huang, Hai; Zhang, Qunfei

2011-09-01

In order to solve the distributed detection fusion problem of underwater target detection, when the signal to noise ratio (SNR) of the acoustic channel is low, a new strategy for united detection fusion and communication using multiple sensors was proposed. The performance of detection fusion was studied and compared based on the Neyman-Pearson principle when the binary phase shift keying (BPSK) and on-off keying (OOK) modes were used by the local sensors. The comparative simulation and analysis between the optimal likelihood ratio test and the proposed strategy was completed, and both the theoretical analysis and simulation indicate that using the proposed new strategy could improve the detection performance effectively. In theory, the proposed strategy of united detection fusion and communication is of great significance to the establishment of an underwater target detection system.

Improved adaptive splitting and selection: the hybrid training method of a classifier based on a feature space partitioning.

PubMed

Jackowski, Konrad; Krawczyk, Bartosz; Woźniak, Michał

2014-05-01

Currently, methods of combined classification are the focus of intense research. A properly designed group of combined classifiers exploiting knowledge gathered in a pool of elementary classifiers can successfully outperform a single classifier. There are two essential issues to consider when creating combined classifiers: how to establish the most comprehensive pool and how to design a fusion model that allows for taking full advantage of the collected knowledge. In this work, we address the issues and propose an AdaSS+, training algorithm dedicated for the compound classifier system that effectively exploits local specialization of the elementary classifiers. An effective training procedure consists of two phases. The first phase detects the classifier competencies and adjusts the respective fusion parameters. The second phase boosts classification accuracy by elevating the degree of local specialization. The quality of the proposed algorithms are evaluated on the basis of a wide range of computer experiments that show that AdaSS+ can outperform the original method and several reference classifiers.

Efficient implicit LES method for the simulation of turbulent cavitating flows

DOE Office of Scientific and Technical Information (OSTI.GOV)

Egerer, Christian P., E-mail: christian.egerer@aer.mw.tum.de; Schmidt, Steffen J.; Hickel, Stefan

2016-07-01

We present a numerical method for efficient large-eddy simulation of compressible liquid flows with cavitation based on an implicit subgrid-scale model. Phase change and subgrid-scale interface structures are modeled by a homogeneous mixture model that assumes local thermodynamic equilibrium. Unlike previous approaches, emphasis is placed on operating on a small stencil (at most four cells). The truncation error of the discretization is designed to function as a physically consistent subgrid-scale model for turbulence. We formulate a sensor functional that detects shock waves or pseudo-phase boundaries within the homogeneous mixture model for localizing numerical dissipation. In smooth regions of the flowmore » field, a formally non-dissipative central discretization scheme is used in combination with a regularization term to model the effect of unresolved subgrid scales. The new method is validated by computing standard single- and two-phase test-cases. Comparison of results for a turbulent cavitating mixing layer obtained with the new method demonstrates its suitability for the target applications.« less

42.8 Gb/s ASK homodyne receiver using standard DFB lasers

NASA Astrophysics Data System (ADS)

Becker, D.; Mohr, D.; Datta, S.; Wree, C.; Bhandare, S.; Joshi, A.

2009-05-01

Optical synchronous coherent detection is attracting greater attention within the defense and security community because it allows linear recovery both of the amplitude and phase of optical signals. Fiber-based transmission impairments such as chromatic dispersion and polarization mode dispersion can be compensated in the electrical domain. Additionally, synchronous detection offers the potential of improved receiver sensitivity and extended reach versus direct or interferometric detection schemes. 28 Gbaud/112 Gb/s and 42.8 Gbaud transmissions are now being considered in fiber networks worldwide. Due to the lack of broadband high frequency components centered at IF values of 56 GHz and 86 GHz, respectively, the coherent heterodyne approach is not viable for these baud rates. The homodyne approach remains one of the choices available to fully exploit the advantages of synchronous coherent detection at these transmission data rates. In order to implement the homodyne receiver, optical phase locking between the signal and local oscillator laser (LO) is required. Digital approaches for this task rely upon very complex, fast, and high power-consumption chips. A homodyne receiver using an analog approach for phase locking would allow for increased system simplicity at a lower cost. Use of commercial-off-the-shelf (COTS) DFB lasers embedded within the receiver would also increase system feasibility for defense applications. We demonstrate synchronous demodulation of a 42.8 Gbaud signal using an analog optical phase-locked loop. The homodyne system was optimized to use COTS DFB lasers having an aggregate linewidth of ~2 MHz. We also analyze the impact of uncompensated phase noise on receiver performance.

Electroosmotic flow and Joule heating in preparative continuous annular electrochromatography.

PubMed

Laskowski, René; Bart, Hans-Jörg

2015-09-01

An openFOAM "computational fluid dynamic" simulation model was developed for the description of local interaction of hydrodynamics and Joule heating in annular electrochromatography. A local decline of electrical conductivity of the background eluent is caused by an electrokinetic migration of ions resulting in higher Joule heat generation. The model equations consider the Navier-Stokes equation for incompressible fluids, the energy equation for stationary temperature fields, and the mass transfer equation for the electrokinetic flow. The simulations were embedded in commercial ANSYS Fluent software and in open-source environment openFOAM. The annular gap (1 mm width) contained an inorganic C8 reverse-phase monolith as stationary phase prepared by an in situ sol-gel process. The process temperature generated by Joule heating was determined by thermal camera system. The local hydrodynamics in the prototype was detected by a gravimetric contact-free measurement method and experimental and simulated values matched quite well. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Automatic Detection of Optic Disc in Retinal Image by Using Keypoint Detection, Texture Analysis, and Visual Dictionary Techniques

PubMed Central

Bayır, Şafak

2016-01-01

With the advances in the computer field, methods and techniques in automatic image processing and analysis provide the opportunity to detect automatically the change and degeneration in retinal images. Localization of the optic disc is extremely important for determining the hard exudate lesions or neovascularization, which is the later phase of diabetic retinopathy, in computer aided eye disease diagnosis systems. Whereas optic disc detection is fairly an easy process in normal retinal images, detecting this region in the retinal image which is diabetic retinopathy disease may be difficult. Sometimes information related to optic disc and hard exudate information may be the same in terms of machine learning. We presented a novel approach for efficient and accurate localization of optic disc in retinal images having noise and other lesions. This approach is comprised of five main steps which are image processing, keypoint extraction, texture analysis, visual dictionary, and classifier techniques. We tested our proposed technique on 3 public datasets and obtained quantitative results. Experimental results show that an average optic disc detection accuracy of 94.38%, 95.00%, and 90.00% is achieved, respectively, on the following public datasets: DIARETDB1, DRIVE, and ROC. PMID:27110272

Dynamic CT for Parathyroid Adenoma Detection: How Does Radiation Dose Compare With Nuclear Medicine?

PubMed

Czarnecki, Caroline A; Einsiedel, Paul F; Phal, Pramit M; Miller, Julie A; Lichtenstein, Meir; Stella, Damien L

2018-05-01

Dynamic CT is increasingly used for preoperative localization of parathyroid adenomas, but concerns remain about the radiation effective dose of CT compared with that of 99m Tc-sestamibi scintigraphy. The purpose of this study was to compare the radiation dose delivered by three-phase dynamic CT with that delivered by 99m Tc-sestamibi SPECT/CT performed in accordance with our current protocols and to assess the possible reduction in effective dose achieved by decreasing the scan length (i.e., z-axis) of two phases of the dynamic CT protocol. The effective dose of a 99m Tc-sestamibi nuclear medicine parathyroid study performed with and without coregistration CT was calculated and compared with the effective dose of our current three-phase dynamic CT protocol as well as a proposed protocol involving CT with reduced scan length. The median effective dose for a 99m Tc-sestamibi nuclear medicine study was 5.6 mSv. This increased to 12.4 mSv with the addition of coregistration CT, which is higher than the median effective dose of 9.3 mSv associated with the dynamic CT protocol. Reducing the scan length of two phases in the dynamic CT protocol could reduce the median effective dose to 6.1 mSv, which would be similar to that of the dose from the 99m Tc-sestamibi study alone. Dynamic CT used for the detection of parathyroid adenoma can deliver a lower radiation dose than 99m Tc-sestamibi SPECT/CT. It may be possible to reduce the dose further by decreasing the scan length of two of the phases, although whether this has an impact on accuracy of the localization needs further investigation.

Musical Stairs: A motivational therapy tool for children with disabilities featuring automated detection of stair-climbing gait events via inertial sensors.

PubMed

Khan, Ajmal; Biddiss, Elaine

2017-02-01

Stair-climbing is a key component of rehabilitation therapies for children with physical disabilities. This paper reports on the design of a system, Musical Stairs, to provide auditory feedback during stair-climbing therapies. Musical Stairs is composed of two foot-mounted inertial sensors, a step detection algorithm, and an auditory feedback response. In Phase 1, we establish its clinical feasibility via a Wizard-of-Oz AB/BA cross-over design with 17 children, aged 4-6 years, having diverse diagnoses and gait abilities. Self-, therapist- and blinded-observer reports indicated increased motivation with auditory feedback. Phase 2 describes the construction of a database comprised of synchronized video and inertial data associated with 1568 steps up and down stairs completed by 26 children aged 4-6 years with diverse diagnoses and gait. Lastly, in Phase 3, data from 18 children in the database were used to train a rule-based step detection algorithm based on local minima in the acceleration profile and the foot's swing angle. A step detection rate of 96% [SD=3%] and false positive rate of 6% [SD=5%] were achieved with an independent test set (n=8). Recommendations for future development and evaluation are discussed. Copyright © 2017 IPEM. Published by Elsevier Ltd. All rights reserved.

Tomographic phase analysis to detect the site of accessory conduction pathway in Wolff-Parkinson-White syndrome

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nakajima, K.; Bunko, H.; Tada, A.

1984-01-01

Phase analysis has been applied to Wolff-Parkinson-White syndrome (WPW) to detect the site of accessory conduction pathway (ACP); however, there was a limitation to estimate the precise location of ACP by planar phase analysis. In this study, the authors applied phase analysis to gated blood pool tomography. Twelve patients with WPW who underwent epicardial mapping and surgical division of ACP were studied by both of gated emission computed tomography (GECT) and routine gated blood pool study (GBPS). The GBPS was performed with Tc-99m red blood cells in multiple projections; modified left anterior oblique, right anterior oblique and/or left lateral views.more » In GECT, short axial, horizontal and vertical long axial blood pool images were reconstructed. Phase analysis was performed using fundamental frequency of the Fourier transform in both GECT and GBPS images, and abnormal initial contractions on both the planar and tomographic phase analysis were compared with the location of surgically confirmed ACPs. In planar phase analysis, abnormal initial phase was identified in 7 out of 12 (58%) patients, while in tomographic phase analysis, the localization of ACP was predicted in 11 out of 12 (92%) patients. Tomographic phase analysis is superior to planar phase images in 8 out of 12 patients to estimate the location of ACP. Phase analysis by GECT can avoid overlap of blood pool in cardiac chambers and has advantage to identify the propagation of phase three-dimensionally. Tomographic phase analysis is a good adjunctive method for patients with WPW to estimate the site of ACP.« less

High key rate continuous-variable quantum key distribution with a real local oscillator.

PubMed

Wang, Tao; Huang, Peng; Zhou, Yingming; Liu, Weiqi; Ma, Hongxin; Wang, Shiyu; Zeng, Guihua

2018-02-05

Continuous-variable quantum key distribution (CVQKD) with a real local oscillator (LO) has been extensively studied recently due to its security and simplicity. In this paper, we propose a novel implementation of a high-key-rate CVQKD with a real LO. Particularly, with the help of the simultaneously generated reference pulse, the phase drift of the signal is tracked in real time and then compensated. By utilizing the time and polarization multiplexing techniques to isolate the reference pulse and controlling the intensity of it, not only the contamination from it is suppressed, but also a high accuracy of the phase compensation can be guaranteed. Besides, we employ homodyne detection on the signal to ensure the high quantum efficiency and heterodyne detection on the reference pulse to acquire the complete phase information of it. In order to suppress the excess noise, a theoretical noise model for our scheme is established. According to this model, the impact of the modulation variance and the intensity of the reference pulse are both analysed theoretically and then optimized according to the experimental data. By measuring the excess noise in the 25km optical fiber transmission system, a 3.14Mbps key rate in the asymptotic regime proves to be achievable. This work verifies the feasibility of the high-key-rate CVQKD with a real LO within the metropolitan area.

Facilitating Follow-up of LIGO–Virgo Events Using Rapid Sky Localization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Hsin-Yu; Holz, Daniel E.

We discuss an algorithm for accurate and very low-latency (<1 s) localization of gravitational-wave (GW) sources using only the relative times of arrival, relative phases, and relative signal-to-noise ratios for pairs of detectors. The algorithm is independent of distances and masses to leading order, and can be generalized to all discrete (as opposed to stochastic and continuous) sources detected by ground-based detector networks. Our approach is similar to that of BAYESTAR with a few modifications, which result in increased computational efficiency. For the LIGO two-detector configuration (Hanford+Livingston) operating in O1 we find a median 50% (90%) localization of 143 deg{supmore » 2} (558 deg{sup 2}) for binary neutron stars. We use our algorithm to explore the improvement in localization resulting from loud events, finding that the loudest out of the first 4 (or 10) events reduces the median sky-localization area by a factor of 1.9 (3.0) for the case of two GW detectors, and 2.2 (4.0) for three detectors. We also consider the case of multi-messenger joint detections in both the gravitational and the electromagnetic radiation, and show that joint localization can offer significant improvements (e.g., in the case of LIGO and Fermi /GBM joint detections). We show that a prior on the binary inclination, potentially arising from GRB observations, has a negligible effect on GW localization. Our algorithm is simple, fast, and accurate, and may be of particular utility in the development of multi-messenger astronomy.« less

Nonlinear Dirac cones

NASA Astrophysics Data System (ADS)

Bomantara, Raditya Weda; Zhao, Wenlei; Zhou, Longwen; Gong, Jiangbin

2017-09-01

Physics arising from two-dimensional (2D) Dirac cones has been a topic of great theoretical and experimental interest to studies of gapless topological phases and to simulations of relativistic systems. Such 2D Dirac cones are often characterized by a π Berry phase and are destroyed by a perturbative mass term. By considering mean-field nonlinearity in a minimal two-band Chern insulator model, we obtain a different type of Dirac cone that is robust to local perturbations without symmetry restrictions. Due to a different pseudospin texture, the Berry phase of the Dirac cone is no longer quantized in π , and can be continuously tuned as an order parameter. Furthermore, in an Aharonov-Bohm (AB) interference setup to detect such Dirac cones, the adiabatic AB phase is found to be π both theoretically and computationally, offering an observable topological invariant and a fascinating example where the Berry phase and AB phase are fundamentally different. We hence discover a nonlinearity-induced quantum phase transition from a known topological insulating phase to an unusual gapless topological phase.

Complex local Moho topography in the Western Carpathians: Indication of the ALCAPA and the European Plate contact

NASA Astrophysics Data System (ADS)

Hrubcová, Pavla; Środa, Piotr

2015-01-01

Seismic data from deep refraction and wide-angle reflection profiles intersecting the Western Carpathians show distinct upper-mantle Pn phases with anomalous apparent velocities identified in the first and later arrivals. Their systematic analysis indicates that such phases are present in numerous seismic sections both for in-line and off-line shots. They are observed in data from profiles intersecting the Carpathians in the west at the contact with the Bohemian Massif; similar feature was also found in data at the northern edge of the Carpathians at the contact with the North European Platform. Modelling of these anomalous Pn phases shows that they originate due to local structural anomalies of the Moho discontinuity detected in several places along the Western Carpathian arc. Such anomalies are located in close lateral proximity of the Pieniny Klippen Belt representing the contact between the stable European Plate in the north and the ALCAPA (Alpine-Carpathian-Pannonian) microplate in the south. Thus, the complex local Moho topography modelled from the Pn phases suggests tectonic relation to the formation of the Carpathian orogen. The result is supported by correlation with the large-scale Carpathian conductivity anomaly modelled in the Carpathians at a mid-crustal level. Relative lateral position of these two structures together with the Pieniny Klippen Belt at the surface delineates a zone affected by deformations at various depths along the whole Western Carpathian arc.

Field-induced polarization rotation and phase transitions in 0.70 Pb ( M g 1 / 3 N b 2 / 3 ) O 3 – 0.30 PbTi O 3 piezoceramics observed by in situ high-energy x-ray scattering

DOE PAGES

Hou, Dong; Usher, Tedi -Marie; Fulanovic, Lovro; ...

2018-06-12

Changes to the crystal structure of 0.70Pb(Mg 1/3Nb 2/3)O 3–0.30PbTiO 3 (PMN-0.30PT) piezoceramic under application of electric fields at the long-range and local scale are revealed by in situ high-energy x-ray diffraction (XRD) and pair-distribution function (PDF) analyses, respectively. The crystal structure of unpoled samples is identified as monoclinic Cm at both the long-range and local scale. In situ XRD results suggest that field-induced polarization rotation and phase transitions occur at specific field strengths. A polarization rotation pathway is proposed based on the Bragg-peak behaviors and the Le Bail fitting results of the in situ XRD patterns. The PDF resultsmore » show systematic changes to the structures at the local scale, which is in agreement with the changes inferred from the in situ XRD study. More importantly, our results prove that polarization rotation can be detected and determined in a polycrystalline relaxor ferroelectric. Furthermore, this study supports the idea that multiple contributions, specifically ferroelectric-ferroelectric phase transition and polarization rotation, are responsible for the high piezoelectric properties at the morphotropic phase boundary of PMN-xPT piezoceramics.« less

Field-induced polarization rotation and phase transitions in 0.70 Pb ( M g 1 / 3 N b 2 / 3 ) O 3 – 0.30 PbTi O 3 piezoceramics observed by in situ high-energy x-ray scattering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hou, Dong; Usher, Tedi -Marie; Fulanovic, Lovro

Changes to the crystal structure of 0.70Pb(Mg 1/3Nb 2/3)O 3–0.30PbTiO 3 (PMN-0.30PT) piezoceramic under application of electric fields at the long-range and local scale are revealed by in situ high-energy x-ray diffraction (XRD) and pair-distribution function (PDF) analyses, respectively. The crystal structure of unpoled samples is identified as monoclinic Cm at both the long-range and local scale. In situ XRD results suggest that field-induced polarization rotation and phase transitions occur at specific field strengths. A polarization rotation pathway is proposed based on the Bragg-peak behaviors and the Le Bail fitting results of the in situ XRD patterns. The PDF resultsmore » show systematic changes to the structures at the local scale, which is in agreement with the changes inferred from the in situ XRD study. More importantly, our results prove that polarization rotation can be detected and determined in a polycrystalline relaxor ferroelectric. Furthermore, this study supports the idea that multiple contributions, specifically ferroelectric-ferroelectric phase transition and polarization rotation, are responsible for the high piezoelectric properties at the morphotropic phase boundary of PMN-xPT piezoceramics.« less

Field-induced polarization rotation and phase transitions in 0.70 Pb (M g1 /3N b2 /3 ) O3-0.30 PbTi O3 piezoceramics observed by in situ high-energy x-ray scattering

NASA Astrophysics Data System (ADS)

Hou, Dong; Usher, Tedi-Marie; Fulanovic, Lovro; Vrabelj, Marko; Otonicar, Mojca; Ursic, Hana; Malic, Barbara; Levin, Igor; Jones, Jacob L.

2018-06-01

Changes to the crystal structure of 0.70 Pb (M g1 /3N b2 /3 ) O3-0.30 PbTi O3 (PMN-0.30PT) piezoceramic under application of electric fields at the long-range and local scale are revealed by in situ high-energy x-ray diffraction (XRD) and pair-distribution function (PDF) analyses, respectively. The crystal structure of unpoled samples is identified as monoclinic C m at both the long-range and local scale. In situ XRD results suggest that field-induced polarization rotation and phase transitions occur at specific field strengths. A polarization rotation pathway is proposed based on the Bragg-peak behaviors and the Le Bail fitting results of the in situ XRD patterns. The PDF results show systematic changes to the structures at the local scale, which is in agreement with the changes inferred from the in situ XRD study. More importantly, our results prove that polarization rotation can be detected and determined in a polycrystalline relaxor ferroelectric. This study supports the idea that multiple contributions, specifically ferroelectric-ferroelectric phase transition and polarization rotation, are responsible for the high piezoelectric properties at the morphotropic phase boundary of PMN-x PT piezoceramics.

Lindemann histograms as a new method to analyse nano-patterns and phases

NASA Astrophysics Data System (ADS)

Makey, Ghaith; Ilday, Serim; Tokel, Onur; Ibrahim, Muhamet; Yavuz, Ozgun; Pavlov, Ihor; Gulseren, Oguz; Ilday, Omer

The detection, observation, and analysis of material phases and atomistic patterns are of great importance for understanding systems exhibiting both equilibrium and far-from-equilibrium dynamics. As such, there is intense research on phase transitions and pattern dynamics in soft matter, statistical and nonlinear physics, and polymer physics. In order to identify phases and nano-patterns, the pair correlation function is commonly used. However, this approach is limited in terms of recognizing competing patterns in dynamic systems, and lacks visualisation capabilities. In order to solve these limitations, we introduce Lindemann histogram quantification as an alternative method to analyse solid, liquid, and gas phases, along with hexagonal, square, and amorphous nano-pattern symmetries. We show that the proposed approach based on Lindemann parameter calculated per particle maps local number densities to material phase or particles pattern. We apply the Lindemann histogram method on dynamical colloidal self-assembly experimental data and identify competing patterns.

An automated multi-scale network-based scheme for detection and location of seismic sources

NASA Astrophysics Data System (ADS)

Poiata, N.; Aden-Antoniow, F.; Satriano, C.; Bernard, P.; Vilotte, J. P.; Obara, K.

2017-12-01

We present a recently developed method - BackTrackBB (Poiata et al. 2016) - allowing to image energy radiation from different seismic sources (e.g., earthquakes, LFEs, tremors) in different tectonic environments using continuous seismic records. The method exploits multi-scale frequency-selective coherence in the wave field, recorded by regional seismic networks or local arrays. The detection and location scheme is based on space-time reconstruction of the seismic sources through an imaging function built from the sum of station-pair time-delay likelihood functions, projected onto theoretical 3D time-delay grids. This imaging function is interpreted as the location likelihood of the seismic source. A signal pre-processing step constructs a multi-band statistical representation of the non stationary signal, i.e. time series, by means of higher-order statistics or energy envelope characteristic functions. Such signal-processing is designed to detect in time signal transients - of different scales and a priori unknown predominant frequency - potentially associated with a variety of sources (e.g., earthquakes, LFE, tremors), and to improve the performance and the robustness of the detection-and-location location step. The initial detection-location, based on a single phase analysis with the P- or S-phase only, can then be improved recursively in a station selection scheme. This scheme - exploiting the 3-component records - makes use of P- and S-phase characteristic functions, extracted after a polarization analysis of the event waveforms, and combines the single phase imaging functions with the S-P differential imaging functions. The performance of the method is demonstrated here in different tectonic environments: (1) analysis of the one year long precursory phase of 2014 Iquique earthquake in Chile; (2) detection and location of tectonic tremor sources and low-frequency earthquakes during the multiple episodes of tectonic tremor activity in southwestern Japan.

External detection and localization of well leaks in aquifer zones

NASA Astrophysics Data System (ADS)

Haas, Allan K.

This dissertation presents a new methodology for monitoring, detecting, and localizing shallow, aquifer zone leaks in oil and gas wells. The rationale for this type of leak detection is to close the knowledge gap associated with public claims of subsurface water resource contamination caused by the oil and gas industry. A knowledge gap exists because there is no data, one way or the other, that can definitively prove or deny the existence of subsurface leakage pathways in oil and gas wells, new, old or abandoned. This dissertation begins with an overview of existing and future oil and gas well leak detection methods, and then presents three published papers, each describing a different phenomena that can be exploited for leak monitoring, detection, localization, and damage extent determination. The first paper describes the direct detection and localization of a leak that was discovered during a laboratory based hydraulic fracturing experiment. The second paper describes the laboratory measured electrical response that occurs during two phase flow inside of porous media. The third paper describes the detection and tracking of a gravity driven salt plume leak in a freshwater test tank in the laboratory. the three geophysical approaches that are presented, when combined together, provide a new, powerful, external to the well method to monitor, detect, localize, and assess the damage from leaks in the drinking water protection zone of oil and gas wells. This is a capability that is not available in any other leak detection and localization method. This dissertation also presents a chapter of Science, Technology and Society (STS), and Science, and Technology Policy (STP) as a final fulfillment requirement of the SmartGeo Fellowship program, and the Science, Technology, Engineering, and Policy minor. This chapter introduces a new STS/STP concept concerning the after effects of knowledge boundary disputes. This new concept is called the residual footprints of knowledge boundary disputes. This new concept is developed through the analysis of an oil and gas drilling controversy that climaxed in Erie, CO in 2012. Additional evidence of this residual footprint concept is also presented in a very brief form. It is hoped that this new concept will be further researched, and adopted by the STS/STP community.

Lead(ii) soaps: crystal structures, polymorphism, and solid and liquid mesophases.

PubMed

Martínez-Casado, F J; Ramos-Riesco, M; Rodríguez-Cheda, J A; Redondo-Yélamos, M I; Garrido, L; Fernández-Martínez, A; García-Barriocanal, J; da Silva, I; Durán-Olivencia, M; Poulain, A

2017-07-05

The long-chain members of the lead(ii) alkanoate series or soaps, from octanoate to octadecanoate, have been thoroughly characterized by means of XRD, PDF analysis, DSC, FTIR, ssNMR and other techniques, in all their phases and mesophases. The crystal structures at room temperature of all of the members of the series are now solved, showing the existence of two polymorphic forms in the room temperature crystal phase, different to short and long-chain members. Only nonanoate and decanoate present both forms, and this polymorphism is proven to be monotropic. At higher temperature, these compounds present a solid mesophase, defined as rotator, a liquid crystal phase and a liquid phase, all of which have a similar local arrangement. Since some lead(ii) soaps appear as degradation compounds in oil paintings, the solved crystal structures of lead(ii) soaps can now be used as fingerprints for their detection using X-ray diffraction. Pair distribution function analysis on these compounds is very similar in the same phases and mesophases for the different members, showing the same short range order. This observation suggests that this technique could also be used in the detection of these compounds in disordered phases or in the initial stages of formation in paintings.

HPLC-DAD-ESI/MS identification of light harvesting and light screening pigments in the lake sediments at Edmonson Point.

PubMed

Giovannetti, Rita; Alibabaei, Leila; Zannotti, Marco; Ferraro, Stefano; Petetta, Laura

2013-01-01

The composition of sedimentary pigments in the Antarctic lake at Edmonson Point has been investigated and compared with the aim to provide a useful analytical method for pigments separation and identification, providing reference data for future assessment of possible changes in environmental conditions. Reversed phase high performance liquid chromatography (HPLC) with electrospray-mass spectrometry (ESI-MS) detection and diode array detection (DAD) has been used to identify light screening and light harvesting pigments. The results are discussed in terms of local environmental conditions.

Short-Circuit Fault Detection and Classification Using Empirical Wavelet Transform and Local Energy for Electric Transmission Line.

PubMed

Huang, Nantian; Qi, Jiajin; Li, Fuqing; Yang, Dongfeng; Cai, Guowei; Huang, Guilin; Zheng, Jian; Li, Zhenxin

2017-09-16

In order to improve the classification accuracy of recognizing short-circuit faults in electric transmission lines, a novel detection and diagnosis method based on empirical wavelet transform (EWT) and local energy (LE) is proposed. First, EWT is used to deal with the original short-circuit fault signals from photoelectric voltage transformers, before the amplitude modulated-frequency modulated (AM-FM) mode with a compactly supported Fourier spectrum is extracted. Subsequently, the fault occurrence time is detected according to the modulus maxima of intrinsic mode function (IMF₂) from three-phase voltage signals processed by EWT. After this process, the feature vectors are constructed by calculating the LE of the fundamental frequency based on the three-phase voltage signals of one period after the fault occurred. Finally, the classifier based on support vector machine (SVM) which was constructed with the LE feature vectors is used to classify 10 types of short-circuit fault signals. Compared with complementary ensemble empirical mode decomposition with adaptive noise (CEEMDAN) and improved CEEMDAN methods, the new method using EWT has a better ability to present the frequency in time. The difference in the characteristics of the energy distribution in the time domain between different types of short-circuit faults can be presented by the feature vectors of LE. Together, simulation and real signals experiment demonstrate the validity and effectiveness of the new approach.

Short-Circuit Fault Detection and Classification Using Empirical Wavelet Transform and Local Energy for Electric Transmission Line

PubMed Central

Huang, Nantian; Qi, Jiajin; Li, Fuqing; Yang, Dongfeng; Cai, Guowei; Huang, Guilin; Zheng, Jian; Li, Zhenxin

2017-01-01

In order to improve the classification accuracy of recognizing short-circuit faults in electric transmission lines, a novel detection and diagnosis method based on empirical wavelet transform (EWT) and local energy (LE) is proposed. First, EWT is used to deal with the original short-circuit fault signals from photoelectric voltage transformers, before the amplitude modulated-frequency modulated (AM-FM) mode with a compactly supported Fourier spectrum is extracted. Subsequently, the fault occurrence time is detected according to the modulus maxima of intrinsic mode function (IMF2) from three-phase voltage signals processed by EWT. After this process, the feature vectors are constructed by calculating the LE of the fundamental frequency based on the three-phase voltage signals of one period after the fault occurred. Finally, the classifier based on support vector machine (SVM) which was constructed with the LE feature vectors is used to classify 10 types of short-circuit fault signals. Compared with complementary ensemble empirical mode decomposition with adaptive noise (CEEMDAN) and improved CEEMDAN methods, the new method using EWT has a better ability to present the frequency in time. The difference in the characteristics of the energy distribution in the time domain between different types of short-circuit faults can be presented by the feature vectors of LE. Together, simulation and real signals experiment demonstrate the validity and effectiveness of the new approach. PMID:28926953

Contrast-enhanced ultrasound in the diagnosis of nodules in liver cirrhosis

PubMed Central

Kim, Tae Kyoung; Jang, Hyun-Jung

2014-01-01

Contrast-enhanced ultrasound (CEUS) using microbubble contrast agents are useful for the diagnosis of the nodules in liver cirrhosis. CEUS can be used as a problem-solving method for indeterminate nodules on computed tomography (CT) or magnetic resonance imaging (MRI) or as an initial diagnostic test for small newly detected liver nodules. CEUS has unique advantages over CT and MRI including no renal excretion of contrast, real-time imaging capability, and purely intravascular contrast. Hepatocellular carcinoma (HCC) is characterized by arterial-phase hypervascularity and later washout (negative enhancement). Benign nodules such as regenerative nodules or dysplastic nodules are usually isoechoic or slightly hypoechoic in the arterial phase and isoechoic in the late phase. However, there are occasional HCC lesions with atypical enhancement including hypovascular HCC and hypervascular HCC without washout. Cholangiocarcinomas are infrequently detected during HCC surveillance and mostly show rim-like or diffuse hypervascularity followed by rapid washout. Hemangiomas are often found at HCC surveillance and are easily diagnosed by CEUS. CEUS can be effectively used in the diagnostic work-up of small nodules detected at HCC surveillance. CEUS is also useful to differentiate malignant and benign venous thrombosis and to guide and monitor the local ablation therapy for HCC. PMID:24707142

Contrast-enhanced ultrasound in the diagnosis of nodules in liver cirrhosis.

PubMed

Kim, Tae Kyoung; Jang, Hyun-Jung

2014-04-07

Contrast-enhanced ultrasound (CEUS) using microbubble contrast agents are useful for the diagnosis of the nodules in liver cirrhosis. CEUS can be used as a problem-solving method for indeterminate nodules on computed tomography (CT) or magnetic resonance imaging (MRI) or as an initial diagnostic test for small newly detected liver nodules. CEUS has unique advantages over CT and MRI including no renal excretion of contrast, real-time imaging capability, and purely intravascular contrast. Hepatocellular carcinoma (HCC) is characterized by arterial-phase hypervascularity and later washout (negative enhancement). Benign nodules such as regenerative nodules or dysplastic nodules are usually isoechoic or slightly hypoechoic in the arterial phase and isoechoic in the late phase. However, there are occasional HCC lesions with atypical enhancement including hypovascular HCC and hypervascular HCC without washout. Cholangiocarcinomas are infrequently detected during HCC surveillance and mostly show rim-like or diffuse hypervascularity followed by rapid washout. Hemangiomas are often found at HCC surveillance and are easily diagnosed by CEUS. CEUS can be effectively used in the diagnostic work-up of small nodules detected at HCC surveillance. CEUS is also useful to differentiate malignant and benign venous thrombosis and to guide and monitor the local ablation therapy for HCC.

Prostate Brachytherapy Seed Reconstruction with Gaussian Blurring and Optimal Coverage Cost

PubMed Central

Lee, Junghoon; Liu, Xiaofeng; Jain, Ameet K.; Song, Danny Y.; Burdette, E. Clif; Prince, Jerry L.; Fichtinger, Gabor

2009-01-01

Intraoperative dosimetry in prostate brachytherapy requires localization of the implanted radioactive seeds. A tomosynthesis-based seed reconstruction method is proposed. A three-dimensional volume is reconstructed from Gaussian-blurred projection images and candidate seed locations are computed from the reconstructed volume. A false positive seed removal process, formulated as an optimal coverage problem, iteratively removes “ghost” seeds that are created by tomosynthesis reconstruction. In an effort to minimize pose errors that are common in conventional C-arms, initial pose parameter estimates are iteratively corrected by using the detected candidate seeds as fiducials, which automatically “focuses” the collected images and improves successive reconstructed volumes. Simulation results imply that the implanted seed locations can be estimated with a detection rate of ≥ 97.9% and ≥ 99.3% from three and four images, respectively, when the C-arm is calibrated and the pose of the C-arm is known. The algorithm was also validated on phantom data sets successfully localizing the implanted seeds from four or five images. In a Phase-1 clinical trial, we were able to localize the implanted seeds from five intraoperative fluoroscopy images with 98.8% (STD=1.6) overall detection rate. PMID:19605321

Factors affecting basket catheter detection of real and phantom rotors in the atria: A computational study.

PubMed

Martinez-Mateu, Laura; Romero, Lucia; Ferrer-Albero, Ana; Sebastian, Rafael; Rodríguez Matas, José F; Jalife, José; Berenfeld, Omer; Saiz, Javier

2018-03-01

Anatomically based procedures to ablate atrial fibrillation (AF) are often successful in terminating paroxysmal AF. However, the ability to terminate persistent AF remains disappointing. New mechanistic approaches use multiple-electrode basket catheter mapping to localize and target AF drivers in the form of rotors but significant concerns remain about their accuracy. We aimed to evaluate how electrode-endocardium distance, far-field sources and inter-electrode distance affect the accuracy of localizing rotors. Sustained rotor activation of the atria was simulated numerically and mapped using a virtual basket catheter with varying electrode densities placed at different positions within the atrial cavity. Unipolar electrograms were calculated on the entire endocardial surface and at each of the electrodes. Rotors were tracked on the interpolated basket phase maps and compared with the respective atrial voltage and endocardial phase maps, which served as references. Rotor detection by the basket maps varied between 35-94% of the simulation time, depending on the basket's position and the electrode-to-endocardial wall distance. However, two different types of phantom rotors appeared also on the basket maps. The first type was due to the far-field sources and the second type was due to interpolation between the electrodes; increasing electrode density decreased the incidence of the second but not the first type of phantom rotors. In the simulations study, basket catheter-based phase mapping detected rotors even when the basket was not in full contact with the endocardial wall, but always generated a number of phantom rotors in the presence of only a single real rotor, which would be the desired ablation target. Phantom rotors may mislead and contribute to failure in AF ablation procedures.

Factors affecting basket catheter detection of real and phantom rotors in the atria: A computational study

PubMed Central

Romero, Lucia; Rodríguez Matas, José F.; Berenfeld, Omer; Saiz, Javier

2018-01-01

Anatomically based procedures to ablate atrial fibrillation (AF) are often successful in terminating paroxysmal AF. However, the ability to terminate persistent AF remains disappointing. New mechanistic approaches use multiple-electrode basket catheter mapping to localize and target AF drivers in the form of rotors but significant concerns remain about their accuracy. We aimed to evaluate how electrode-endocardium distance, far-field sources and inter-electrode distance affect the accuracy of localizing rotors. Sustained rotor activation of the atria was simulated numerically and mapped using a virtual basket catheter with varying electrode densities placed at different positions within the atrial cavity. Unipolar electrograms were calculated on the entire endocardial surface and at each of the electrodes. Rotors were tracked on the interpolated basket phase maps and compared with the respective atrial voltage and endocardial phase maps, which served as references. Rotor detection by the basket maps varied between 35–94% of the simulation time, depending on the basket’s position and the electrode-to-endocardial wall distance. However, two different types of phantom rotors appeared also on the basket maps. The first type was due to the far-field sources and the second type was due to interpolation between the electrodes; increasing electrode density decreased the incidence of the second but not the first type of phantom rotors. In the simulations study, basket catheter-based phase mapping detected rotors even when the basket was not in full contact with the endocardial wall, but always generated a number of phantom rotors in the presence of only a single real rotor, which would be the desired ablation target. Phantom rotors may mislead and contribute to failure in AF ablation procedures. PMID:29505583

Aqueous two-phase systems enable multiplexing of homogeneous immunoassays

PubMed Central

Simon, Arlyne B.; Frampton, John P.; Huang, Nien-Tsu; Kurabayashi, Katsuo; Paczesny, Sophie; Takayama, Shuichi

2014-01-01

Quantitative measurement of protein biomarkers is critical for biomarker validation and early disease detection. Current multiplex immunoassays are time consuming costly and can suffer from low accuracy. For example, multiplex ELISAs require multiple, tedious, washing and blocking steps. Moreover, they suffer from nonspecific antibody cross-reactions, leading to high background and false-positive signals. Here, we show that co-localizing antibody-bead pairs in an aqueous two-phase system (ATPS) enables multiplexing of sensitive, no-wash, homogeneous assays, while preventing nonspecific antibody cross-reactions. Our cross-reaction-free, multiplex assay can simultaneously detect picomolar concentrations of four protein biomarkers ((C-X-C motif) ligand 10 (CXCL10), CXCL9, interleukin (IL)-8 and IL-6) in cell supernatants using a single assay well. The potential clinical utility of the assay is demonstrated by detecting diagnostic biomarkers (CXCL10 and CXCL9) in plasma from 88 patients at the onset of the clinical symptoms of chronic graft-versus-host disease (GVHD). PMID:25083509

Wireless vibration monitoring for damage detection of highway bridges

NASA Astrophysics Data System (ADS)

Whelan, Matthew J.; Gangone, Michael V.; Janoyan, Kerop D.; Jha, Ratneshwar

2008-03-01

The development of low-cost wireless sensor networks has resulted in resurgence in the development of ambient vibration monitoring methods to assess the in-service condition of highway bridges. However, a reliable approach towards assessing the health of an in-service bridge and identifying and localizing damage without a priori knowledge of the vibration response history has yet to be formulated. A two-part study is in progress to evaluate and develop existing and proposed damage detection schemes. The first phase utilizes a laboratory bridge model to investigate the vibration response characteristics induced through introduction of changes to structural members, connections, and support conditions. A second phase of the study will validate the damage detection methods developed from the laboratory testing with progressive damage testing of an in-service highway bridge scheduled for replacement. The laboratory bridge features a four meter span, one meter wide, steel frame with a steel and cement board deck composed of sheet layers to regulate mass loading and simulate deck wear. Bolted connections and elastomeric bearings provide a means for prescribing variable local stiffness and damping effects to the laboratory model. A wireless sensor network consisting of fifty-six accelerometers accommodated by twenty-eight local nodes facilitates simultaneous, real-time and high-rate acquisition of the vibrations throughout the bridge structure. Measurement redundancy is provided by an array of wired linear displacement sensors as well as a scanning laser vibrometer. This paper presents the laboratory model and damage scenarios, a brief description of the developed wireless sensor network platform, an overview of available test and measurement instrumentation within the laboratory, and baseline measurements of dynamic response of the laboratory bridge model.

Automatic temporal segment detection via bilateral long short-term memory recurrent neural networks

NASA Astrophysics Data System (ADS)

Sun, Bo; Cao, Siming; He, Jun; Yu, Lejun; Li, Liandong

2017-03-01

Constrained by the physiology, the temporal factors associated with human behavior, irrespective of facial movement or body gesture, are described by four phases: neutral, onset, apex, and offset. Although they may benefit related recognition tasks, it is not easy to accurately detect such temporal segments. An automatic temporal segment detection framework using bilateral long short-term memory recurrent neural networks (BLSTM-RNN) to learn high-level temporal-spatial features, which synthesizes the local and global temporal-spatial information more efficiently, is presented. The framework is evaluated in detail over the face and body database (FABO). The comparison shows that the proposed framework outperforms state-of-the-art methods for solving the problem of temporal segment detection.

The 2010 Eyjafjallajökull and 2011 Grimsvötn ash plumes as seen by GPS

NASA Astrophysics Data System (ADS)

Grapenthin, R.; Hreinsdottir, S.; Gudmundsson, M. T.

2015-12-01

The injection of a volcanic plume introduces a dynamic, localized, short-term heterogeneity in the atmosphere. Satellite-imagery based remote sensing techniques provide good spatial coverage for the detection of such plumes, but slow satellite repeat times (>30 minutes) and cloud cover can delay, if not entirely prevent, the detection. GPS, in turn, provides excellent temporal coverage, but requires favorable satellite-station-geometry such that the signal propagates through the plume if it is to be used for plume detection and analysis. Two methods exist to detect / analyze ash plumes with GPS: (a) Ash-heavy plumes result in signal dispersion and hence a lowered signal-to-noise ratio (SNR). A lowered SNR, recorded by some receivers, can provide useful information about the plume, such as location and velocity of ascent. These data can be evaluated directly as they are recorded by the receiver; without the need of solving for a receiver's position. (b) Wet plumes refract the GPS signals piercing the plume and hence induce a propagation delay. When solving for a receiver position GPS analysis tools do not model this localized phase delay effect and solutions for plume-piercing satellites do not fit the data well. This can be exploited for plume analysis such as the estimation of changes to the atmospheric refractivity index. We analyze GPS data of the ~2 month 2010 Eyafjallajökull erption and the week-long 2011 Grímsvötn eruption to infer a first order estimate of plume geometry and its progression. Using SNR and phase delay information, we evaluate the evolution of the partitioning of wet versus dry parts of the plume. During the GPS processing we iteratively solve for phase-delay and position and fix other parameters, hence reducing the mapping of least-squares misfit into position estimates and other parameters. Nearly continuous webcam imagery provides independent observations of first-order plume characteristics for the Eyafjallajökull event.

Pore-scale characterization of biogeochemical controls on iron and uranium speciation under flow conditions.

PubMed

Pearce, Carolyn I; Wilkins, Michael J; Zhang, Changyong; Heald, Steve M; Fredrickson, Jim K; Zachara, John M

2012-08-07

Etched silicon microfluidic pore network models (micromodels) with controlled chemical and redox gradients, mineralogy, and microbiology under continuous flow conditions are used for the incremental development of complex microenvironments that simulate subsurface conditions. We demonstrate the colonization of micromodel pore spaces by an anaerobic Fe(III)-reducing bacterial species (Geobacter sulfurreducens) and the enzymatic reduction of a bioavailable Fe(III) phase within this environment. Using both X-ray microprobe and X-ray absorption spectroscopy, we investigate the combined effects of the precipitated Fe(III) phases and the microbial population on uranium biogeochemistry under flow conditions. Precipitated Fe(III) phases within the micromodel were most effectively reduced in the presence of an electron shuttle (AQDS), and Fe(II) ions adsorbed onto the precipitated mineral surface without inducing any structural change. In the absence of Fe(III), U(VI) was effectively reduced by the microbial population to insoluble U(IV), which was precipitated in discrete regions associated with biomass. In the presence of Fe(III) phases, however, both U(IV) and U(VI) could be detected associated with biomass, suggesting reoxidation of U(IV) by localized Fe(III) phases. These results demonstrate the importance of the spatial localization of biomass and redox active metals, and illustrate the key effects of pore-scale processes on contaminant fate and reactive transport.

Three-dimensional characterization of extreme ultraviolet mask blank defects by interference contrast photoemission electron microscopy.

PubMed

Lin, Jingquan; Weber, Nils; Escher, Matthias; Maul, Jochen; Han, Hak-Seung; Merkel, Michael; Wurm, Stefan; Schönhense, Gerd; Kleineberg, Ulf

2008-09-29

A photoemission electron microscope based on a new contrast mechanism "interference contrast" is applied to characterize extreme ultraviolet lithography mask blank defects. Inspection results show that positioning of interference destructive condition (node of standing wave field) on surface of multilayer in the local region of a phase defect is necessary to obtain best visibility of the defect on mask blank. A comparative experiment reveals superiority of the interference contrast photoemission electron microscope (Extreme UV illumination) over a topographic contrast one (UV illumination with Hg discharge lamp) in detecting extreme ultraviolet mask blank phase defects. A depth-resolved detection of a mask blank defect, either by measuring anti-node peak shift in the EUV-PEEM image under varying inspection wavelength condition or by counting interference fringes with a fixed illumination wavelength, is discussed.

Characterization of the local immune response to cyst antigens during the acute and elimination phases of primary murine giardiasis.

PubMed

Abdul-Wahid, Aws; Faubert, Gaétan

2008-05-01

During the course of a giardial infection, the host's immune system is presented with a variety of Giardia antigens as trophozoites differentiate, through encysting cells, to form the infective cysts. Previous studies examining the host's immune response during giardial infections have focused on trophozoite-derived antigens (Ags). In this study, we were interested to determine if the host's immune system reacts to cyst Ags during the acute and elimination phases, when there is cyst shedding. For this purpose, we used antigenic extracts from trophozoites (Troph), encysting cells (ENC), and purified giardial cyst walls (PCW), as well as purified recombinant cyst wall protein 2 (rCWP2). Comparative analysis of the parasite extracts using SDS-PAGE analysis and surface-enhanced laser desorption/ionization time of flight mass spectrometry resulted in the detection of 175 protein entities, of which 26 were Troph-specific proteins, 17 ENC-specific proteins, and 31 were PCW-specific proteins. On the other hand, we detected 34 proteins shared between Troph and ENC, 19 proteins that were shared between ENC and PCW, and 29 proteins that were common to Troph and PCW. Finally, we detected 19 proteins that were shared by all three extract samples. BALB/c mice were infected with 10(5)Giardia muris cysts and sacrificed either at the acute or elimination phases of infection (days 12 and 40, respectively), and lymphocytes were isolated from the Peyer's patches (PP). Using flow cytometry, we detected significant increases in the number of PP-derived CD4(+) and CD19(+), but not CD8(+) lymphocytes. Quantification of the number of mucosal IL-4 and IFN-gamma secreting T-lymphocytes by enzyme-linked immunosorbent spot assay showed that these cells reacted by secreting similar levels of IL-4 and IFN-gamma, regardless of the Ag or the phase of infection. Analysis of intestinal humoral immune responses by ELISA resulted in the detection of Ag-specific IgA and IgG intestinal antibodies. Regardless of the Ag tested, a trend was consistently observed where the concentration of local antibodies was found to be slightly increased by the acute phase, where we detected approximately 200microg/mg of specific IgA and approximately 300ng/ml of specific IgG in intestinal lavage of infected mice. By the elimination phase, the amount of specific antibodies was found to increase to approximately 600microg/mg of specific IgA and approximately 1300ng/ml of specific IgG antibodies. Finally, we tested the biological activity of these antibodies and found that they were able to reduce the ability of trophozoites to differentiate into cysts in vitro. Collectively, we believe these results demonstrate for the first time the existence of significant cellular and humoral immune responses against Giardia cyst Ags that may contribute to the reduction of cyst shedding in infected animals.

G protein-coupled estrogen receptor 1 (GPER, GPR 30) in normal human endometrium and early pregnancy decidua.

PubMed

Kolkova, Z; Noskova, V; Ehinger, A; Hansson, S; Casslén, B

2010-10-01

The recently identified trans-membrane G protein-coupled estrogen receptor 1 (GPER, GPR30) has been implicated in rapid non-genomic effects of estrogens. This focuses on expression and localization of GPER mRNA and protein in normal cyclic endometrium and early pregnancy decidua. Real-time PCR, western blotting, in situ hybridization and immuno-histochemistry were used. Endometrial expression of GPER mRNA was lower in the secretory phase than in the proliferative phase, and even lower in the decidua. The expression pattern was similar to that of ERα mRNA, but different from that of ERβ mRNA. Western blot detected GPER protein as a 54 kDa band in all endometrial and decidual samples. In contrast to the mRNA, GPER protein did not show cyclic variations. Apparently, a lower amount of mRNA is sufficient to maintain protein levels in the secretory phase. GPER mRNA was predominantly localized in the epithelium of mid- and late-proliferative phase endometrium, whereas expression in early proliferative and secretory glands could not be distinguished from the diffuse stromal signal, which was present throughout the cycle. Immuno-staining for GPER was stronger in glandular and luminal epithelium than in the stroma throughout the cycle. The cyclic variations of GPER mRNA obviously relate to strong epithelial expression in the proliferative phase, and the expression pattern suggests regulation by ovarian steroids. GPER protein is present in endometrial tissue throughout the cycle, and the epithelial localization suggests potential functions during sperm migration at mid-cycle, as well as decidualization and blastocyst implantation in the mid-secretory phase.

Influence of geographical scale on the detection of density dependence in the host-parasite system, Arvicola terrestris and Taenia taeniaeformis.

PubMed

Deter, J; Berthier, K; Chaval, Y; Cosson, J F; Morand, S; Charbonnel, N

2006-04-01

Infection by the cestode Taenia taeniaeformis was investigated within numerous cyclic populations of the fossorial water vole Arvicola terrestris sampled during 4 years in Franche-Comté (France). The relative influence of different rodent demographic parameters on the presence of this cestode was assessed by considering (1) the demographic phase of the cycle; (2) density at the local geographical scale (<0.1 km2); (3) mean density at a larger scale (>10 km2). The local scale corresponded to the rodent population (intermediate host), while the large scale corresponded to the definitive host population (wild and feral cats). General linear models based on analyses of 1804 voles revealed the importance of local density but also of year, rodent age, season and interactions between year and season and between age and season. Prevalence was significantly higher in low vole densities than during local outbreaks. By contrast, the large geographical scale density and the demographic phase had less influence on infection by the cestode. The potential impacts of the cestode on the fitness of the host were assessed and infection had no effect on the host body mass, litter size or sexual activity of voles.

Self-referenced continuous-variable quantum key distribution

DOEpatents

Soh, Daniel B. S.; Sarovar, Mohan; Camacho, Ryan

2017-01-24

Various technologies for continuous-variable quantum key distribution without transmitting a transmitter's local oscillator are described herein. A receiver on an optical transmission channel uses an oscillator signal generated by a light source at the receiver's location to perform interferometric detection on received signals. An optical reference pulse is sent by the transmitter on the transmission channel and the receiver computes a phase offset of the transmission based on quadrature measurements of the reference pulse. The receiver can then compensate for the phase offset between the transmitter's reference and the receiver's reference when measuring quadratures of received data pulses.

In-Vivo Imaging of Cell Migration Using Contrast Enhanced MRI and SVM Based Post-Processing.

PubMed

Weis, Christian; Hess, Andreas; Budinsky, Lubos; Fabry, Ben

2015-01-01

The migration of cells within a living organism can be observed with magnetic resonance imaging (MRI) in combination with iron oxide nanoparticles as an intracellular contrast agent. This method, however, suffers from low sensitivity and specificty. Here, we developed a quantitative non-invasive in-vivo cell localization method using contrast enhanced multiparametric MRI and support vector machines (SVM) based post-processing. Imaging phantoms consisting of agarose with compartments containing different concentrations of cancer cells labeled with iron oxide nanoparticles were used to train and evaluate the SVM for cell localization. From the magnitude and phase data acquired with a series of T2*-weighted gradient-echo scans at different echo-times, we extracted features that are characteristic for the presence of superparamagnetic nanoparticles, in particular hyper- and hypointensities, relaxation rates, short-range phase perturbations, and perturbation dynamics. High detection quality was achieved by SVM analysis of the multiparametric feature-space. The in-vivo applicability was validated in animal studies. The SVM detected the presence of iron oxide nanoparticles in the imaging phantoms with high specificity and sensitivity with a detection limit of 30 labeled cells per mm3, corresponding to 19 μM of iron oxide. As proof-of-concept, we applied the method to follow the migration of labeled cancer cells injected in rats. The combination of iron oxide labeled cells, multiparametric MRI and a SVM based post processing provides high spatial resolution, specificity, and sensitivity, and is therefore suitable for non-invasive in-vivo cell detection and cell migration studies over prolonged time periods.

Spatial and Temporal EEG-fMRI Changes During Preictal and Postictal Phases in a Patient With Posttraumatic Epilepsy.

PubMed

Storti, Silvia F; Del Felice, Alessandra; Formaggio, Emanuela; Boscolo Galazzo, Ilaria; Bongiovanni, Luigi G; Cerini, Roberto; Fiaschi, Antonio; Manganotti, Paolo

2015-07-01

The combined use of electroencephalography (EEG) and functional magnetic resonance imaging (EEG-fMRI) in epilepsy allows the noninvasive hemodynamic characterization of epileptic discharge-related neuronal activations. The aim of this study was to investigate pathophysiologic mechanisms underlying epileptic activity by exploring the spatial and temporal distribution of fMRI signal modifications during seizure in a single patient with posttraumatic epilepsy. EEG and fMRI data were acquired during two scanning sessions: a spontaneous critical episode was observed during the first, and interictal events were recorded during the second. The EEG-fMRI data were analyzed using the general linear model (GLM). Blood oxygenation level-dependent (BOLD) localization derived from the preictal and artifact-free postictal phase was concordant with the BOLD localization of the interictal epileptiform discharges identified in the second session, pointing to a left perilesional mesiofrontal area. Of note, BOLD signal modifications were already visible several seconds before seizure onset. In brief, BOLD activations from the preictal, postictal, and interictal epileptiform discharge analysis appear to be concordant with the clinically driven localization hypothesis, whereas a widespread network of activations is detected during the ictal phase in a partial seizure. © EEG and Clinical Neuroscience Society (ECNS) 2014.

Switching between forest and trees: Opposite relationship of progesterone and testosterone to global–local processing

PubMed Central

Pletzer, Belinda; Petasis, Ourania; Cahill, Larry

2014-01-01

Sex differences in attentional selection of global and local components of stimuli have been hypothesized to underlie sex differences in cognitive strategy choice. A Navon figure paradigm was employed in 32 men, 41 naturally cycling women (22 follicular, 19 luteal) and 19 users of oral contraceptives (OCs) containing first to third generation progestins in their active pill phase. Participants were first asked to detect targets at any level (divided attention) and then at either the global or the local level only (focused attention). In the focused attention condition, luteal women showed reduced global advantage (i.e. faster responses to global vs. local targets) compared to men, follicular women and OC users. Accordingly, global advantage during the focused attention condition related significantly positively to testosterone levels and significantly negatively to progesterone, but not estradiol levels in a multiple regression model including all naturally cycling women and men. Interference (i.e. delayed rejection of stimuli displaying targets at the non-attended level) was significantly enhanced in OC users as compared to naturally cycling women and related positively to testosterone levels in all naturally cycling women and men. Remarkably, when analyzed separately for each group, the relationship of testosterone to global advantage and interference was reversed in women during their luteal phase as opposed to men and women during their follicular phase. As global processing is lateralized to the right and local processing to the left hemisphere, we speculate that these effects stem from a testosterone-mediated enhancement of right-hemisphere functioning as well as progesterone-mediated inter-hemispheric decoupling. PMID:24874173

Pirfenidone gel in patients with localized scleroderma: a phase II study.

PubMed

Rodríguez-Castellanos, Marco; Tlacuilo-Parra, Alberto; Sánchez-Enríquez, Sergio; Vélez-Gómez, Ezequiel; Guevara-Gutiérrez, Elizabeth

2015-01-28

Localized scleroderma is an inflammatory disease in its first stages and a fibrotic process in later stages, principally mediated by the transforming growth factor β. To date, there is no standard treatment. The objective of this study was to determine the effectiveness and safety of 8% pirfenidone gel in patients with localized scleroderma. This was an open phase II clinical trial that included 12 patients. Treatment with pirfenidone was indicated, three times daily for 6 months. Patients were evaluated clinically with the modified Localized Scleroderma Skin Severity Index (mLoSSI), as well with a durometer and histologically using hematoxylin and eosin stain and Masson's trichrome stain. The baseline mLoSSI average scores were 5.83 ± 4.80 vs. 0.83 ± 1.75 (P = 0.002) at 6 months. The initial durometer induration of the scleroderma plaques was 35.79 ± 9.10 vs. 32.47 ± 8.97 at 6 months (P = 0.05). We observed histopathological improvement with respect to epidermal atrophy, inflammation, dermal or adipose tissue fibrosis and annex atrophy from 12.25 ± 3.25 to 9.75 ± 4.35 (P = 0.032). The 8% pirfenidone gel application was well tolerated, and no side effects were detected. This is the first study on the therapeutic use of pirfenidone gel in localized scleroderma. It acts on both the inflammatory and the fibrotic phases. Considering its effectiveness, good safety profile and the advantage of topical application, pirfenidone is a treatment option in this condition.

A new method for detecting cerebral hemorrhage in rabbits by magnetic inductive phase shift.

PubMed

Jin, Gui; Sun, Jian; Qin, Mingxin; Tang, Qinghua; Xu, Lin; Ning, Xu; Xu, Jia; Pu, Xianjie; Chen, Mingsheng

2014-02-15

Cerebral hemorrhage, which is an important clinical problem, is often monitored and studied using expensive devices, such as magnetic resonance imaging (MRI) and positron emission tomography (PET) that are unavailable in economically underdeveloped regions. Magnetic induction tomography (MIT) is a new type of non-contact, non-invasive, and low-cost detection technology, and exhibits prospects for wide application, especially for the detection of brain diseases. However, the previous studies on MIT have focused on laboratory models and rarely on in vivo applications because the induced signals produced by biological tissues are notably weak. Based on the symmetry between the two brain hemispheres and the fact that a local brain hemorrhage will not affect the contra-lateral hemisphere, a symmetric cancellation-type sensor detection system, which is characterized by one excitation coil and two receiving coils, was designed to improve the detection sensitivity of MIT. This method was subsequently used to detect the occurrence of cerebral hematomas in rabbits. The average phase drift induced by a 3-ml injection of autologous blood was 1.885°, which is a fivefold improvement compared with the traditional single excitation coil and single receiving coil method. The results indicate that this system has high sensitivity and anti-interference ability and high practical value. © 2013 Published by Elsevier B.V.

Phytoluminographic Detection of Dynamic Variations in Leaf Gaseous Conductivity 1

PubMed Central

Ellenson, James L.

1985-01-01

Gas exchange and plant luminescence (delayed light emission) of a single red kidney bean leaf undergoing synchronous oscillations in gas exchange were recorded and analyzed. Introduction of 1.1 microliter per liter SO2 during these oscillations produced increases in plant luminescence that, when averaged over a portion of the leaf, oscillated in phase with the gas exchange oscillations. However, examination of a video record of the plant luminescence showed not only that luminescence intensities tended to be localized within discrete areas of the leaf, but that the time-dependence of luminescence intensities within these regions varied considerably from the period, amplitude, and often phase of the overall gas exchange oscillations. The video recording also showed that changes in luminescence intensities appeared to migrate across the leaf in wave-like patterns. These data are interpreted in terms of localized fluctuations in gaseous conductances of the leaf. Images Fig. 3 PMID:16664350

Microaneurysms detection with the radon cliff operator in retinal fundus images

NASA Astrophysics Data System (ADS)

Giancardo, Luca; Mériaudeau, Fabrice; Karnowski, Thomas P.; Tobin, Kenneth W.; Li, Yaqin; Chaum, Edward

2010-03-01

Diabetic Retinopathy (DR) is one of the leading causes of blindness in the industrialized world. Early detection is the key in providing effective treatment. However, the current number of trained eye care specialists is inadequate to screen the increasing number of diabetic patients. In recent years, automated and semi-automated systems to detect DR with color fundus images have been developed with encouraging, but not fully satisfactory results. In this study we present the initial results of a new technique for the detection and localization of microaneurysms, an early sign of DR. The algorithm is based on three steps: candidates selection, the actual microaneurysms detection and a final probability evaluation. We introduce the new Radon Cliff operator which is our main contribution to the field. Making use of the Radon transform, the operator is able to detect single noisy Gaussian-like circular structures regardless of their size or strength. The advantages over existing microaneurysms detectors are manifold: the size of the lesions can be unknown, it automatically distinguishes lesions from the vasculature and it provides a fair approach to microaneurysm localization even without post-processing the candidates with machine learning techniques, facilitating the training phase. The algorithm is evaluated on a publicly available dataset from the Retinopathy Online Challenge.

Multiparametric Magnetic Resonance Imaging of the Prostate for Tumour Detection and Local Staging: Imaging in 1.5T and Histopathologic Correlation.

PubMed

Loggitsi, Dimitra; Gyftopoulos, Anastasios; Economopoulos, Nikolaos; Apostolaki, Aikaterini; Kalogeropoulos, Theodoros; Thanos, Anastasios; Alexopoulou, Efthimia; Kelekis, Nikolaos L

2017-11-01

The study sought to prospectively evaluate which technique among T2-weighted images, dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), diffusion-weighted (DW) MRI, or a combination of the 2, is best suited for prostate cancer detection and local staging. Twenty-seven consecutive patients with biopsy-proven adenocarcinoma of the prostate underwent MRI on a 1.5T scanner with a surface phased-array coil prior radical prostatectomy. Combined anatomical and functional imaging was performed with the use of T2-weighted sequences, DCE MRI, and DW MRI. We compared the imaging results with whole mount histopathology. For the multiparametric approach, significantly higher sensitivity values, that is, 53% (95% confidence interval [CI]: 41.0-64.1) were obtained as compared with each modality alone or any combination of the 3 modalities (P < .05). The specificity for this multiparametric approach, being 90.3% (95% CI: 86.3-93.3) was not significantly higher (P < .05) as compared with the values of the combination of T2+DCE MRI, DW+DCE MRI, or DCE MRI alone. Among the 3 techniques, DCE had the best performance for tumour detection in both the peripheral and the transition zone. High negative predictive value rates (>86%) were obtained for both tumour detection and local staging. The combination of T2-weighted sequences, DCE MRI, and DW MRI yields higher diagnostic performance for tumour detection and local staging than can any of these techniques alone or even any combination of them. Copyright © 2017 Canadian Association of Radiologists. Published by Elsevier Inc. All rights reserved.

UV plasmonic device for sensing ethanol and acetone

NASA Astrophysics Data System (ADS)

Honda, Mitsuhiro; Ichikawa, Yo; Rozhin, Alex G.; Kulinich, Sergei A.

2018-01-01

In the present study, we demonstrate efficient detection of volatile organic vapors with improved sensitivity, exploiting the localized surface plasmon resonance of indium nanograins in the UV range (UV-LSPR). The sensitivity of deep-UV-LSPR measurements toward ethanol was observed to be 0.004 nm/ppm, which is 10 times higher than that of a previously reported visible-LSPR device based on Ag nanoprisms [Sensors 11, 8643 (2011)]. Although practical issues such as improving detection limits are still remaining, the results of the present study suggest that the new approach based on UV-LSPR may open new avenues to the detection of organic molecules in solid, liquid, and gas phases using plasmonic sensors.

Relative Influence of Intrinsic and Extrinsic Factors on the Metal-Insulator Transition of VO2 Nanowires

NASA Astrophysics Data System (ADS)

Kim, In Soo

The influence of stoichiometry on the metal-insulator transition of vanadium dioxide (VO2) nanowires was investigated using Raman spectroscopy. Controlled reduction of nominally strain-free suspended VO2 nanowires was conducted by rapid thermal annealing (RTA). The deficiency in oxygen assisted in the unprecedented suppression of the metallic (R) phase to temperatures as low as 103 K through generation of free electrons. In a complementary manner, oxygen-rich conditions stabilized the metastable monoclinic (M2) and triclinic (T) phases. A pseudo-phase diagram with dimensions of temperature and stoichiometry was established, highlighting the accessibility of new phases in the nanowire geometry. Detection of the dynamic elastic response across the metal-insulator transition in suspended VO2 nanowires was enabled by fiber-coupled polarization dependent interferometry. Dual-beam Raman spectroscopy was developed to determine the local domain/phase structure of VO2 nanowires, which allowed for accurate modeling using COMSOL finite element analysis (FEA). The Young's moduli of the single crystal insulating (M1) and metallic (R) phases without artifacts were determined for the first time. The sources of dissipation were identified as clamping losses, structural losses, thermoelastic damping, and domain wall motion. While contribution of thermoelastic damping was found to be dominant in the terminal phases, extraordinary dissipation was observed upon formation and movement of domain walls. Finally, it was shown that creation of local defects could lead to new classes of tunable sensors with a discrete and programmable frequency response with temperature.

Influence of the local structure in phase-change materials on their dielectric permittivity.

PubMed

Shportko, Kostiantyn V; Venger, Eugen F

2015-01-01

Ge-Sb-Te alloys, which belong to the phase-change materials, are promising materials for data storage and display and data visualization applications due to their unique properties. This includes a remarkable difference of their electrical and optical properties in the amorphous and crystalline state. Pronounced change of optical properties for Ge-Sb-Te alloys is linked to the different bonding types and different atomic arrangements in amorphous and crystalline states. The dielectric function of phase-change materials has been investigated in the far infrared (FIR) range. Phonons have been detected by FTIR spectroscopy. Difference of the dispersion of the dielectric permittivity of amorphous and crystalline samples is caused by different structures in different states which contribute to the dielectric permittivity.

Sporadic incidence of Fascioliasis detected during hepatobiliary procedures: a study of 18 patients from Sulaimaniyah governorate.

PubMed

Hawramy, Tahir Abdullah Hussein; Saeed, Kamal Ahmed; Qaradaghy, Seerwan Hama Sharif; Karboli, Taha Ahmed; Nore, Beston Faiek; Bayati, Noora Hisham Abood

2012-12-21

Fascioliasis is an often-neglected zoonotic disease and currently is an emerging infection in Iraq. Fascioliasis has two distinct phases, an acute phase, exhibiting the hepatic migratory stage of the fluke's life cycle, and a chronic biliary phase manifested with the presence of the parasite in the bile ducts through hepatic tissue. The incidence of Fascioliasis in Sulaimaniyah governorate was unexpected observation. We believe that shedding light on this disease in our locality will increase our physician awareness and experience in early detection, treatment in order to avoid unnecessary surgeries. We retrospectively evaluated this disease in terms of the demographic features, clinical presentations, and managements by reviewing the medical records of 18 patients, who were admitted to the Sulaimani Teaching Hospital and Kurdistan Centre for Gastroenterology and Hepatology. Patients were complained from hepatobiliary and/or upper gastrointestinal symptoms and diagnosed accidentally with Fascioliasis during hepatobiliary surgeries and ERCP by direct visualization of the flukes and stone analysis. Elevated liver enzymes, white blood cells count and eosinophilia were notable laboratory indices. The dilated CBD, gallstones, liver cysts and abscess were found common in radiological images. Fascioliasis diagnosed during conventional surgical CBD exploration and choledochodoudenostomy, open cholecystectomy, surgical drainage of liver abscess, ERCP and during gallstone analysis. Fascioliasis is indeed an emerging disease in our locality, but it is often underestimated and ignored. We recommend the differential diagnosis of patients suffering from Rt. Hypochondrial pain, fever and eosinophilia. The watercress ingestion was a common factor in patient's history.

Transformation from a pure time delay to a mixed time and phase delay representation in the auditory forebrain pathway.

PubMed

Vonderschen, Katrin; Wagner, Hermann

2012-04-25

Birds and mammals exploit interaural time differences (ITDs) for sound localization. Subsequent to ITD detection by brainstem neurons, ITD processing continues in parallel midbrain and forebrain pathways. In the barn owl, both ITD detection and processing in the midbrain are specialized to extract ITDs independent of frequency, which amounts to a pure time delay representation. Recent results have elucidated different mechanisms of ITD detection in mammals, which lead to a representation of small ITDs in high-frequency channels and large ITDs in low-frequency channels, resembling a phase delay representation. However, the detection mechanism does not prevent a change in ITD representation at higher processing stages. Here we analyze ITD tuning across frequency channels with pure tone and noise stimuli in neurons of the barn owl's auditory arcopallium, a nucleus at the endpoint of the forebrain pathway. To extend the analysis of ITD representation across frequency bands to a large neural population, we employed Fourier analysis for the spectral decomposition of ITD curves recorded with noise stimuli. This method was validated using physiological as well as model data. We found that low frequencies convey sensitivity to large ITDs, whereas high frequencies convey sensitivity to small ITDs. Moreover, different linear phase frequency regimes in the high-frequency and low-frequency ranges suggested an independent convergence of inputs from these frequency channels. Our results are consistent with ITD being remodeled toward a phase delay representation along the forebrain pathway. This indicates that sensory representations may undergo substantial reorganization, presumably in relation to specific behavioral output.

Phase Acrobatics: The Influence of Excitonic Resonance and Gold Nonresonant Background on Heterodyne-Detected Vibrational Sum Frequency Generation Emission.

PubMed

Rich, Christopher C; Lindberg, Kathryn A; Krummel, Amber T

2017-04-06

We show how heterodyne-detected vibrational sum frequency generation (HD-VSFG) spectroscopy can discriminate between the excitonic and monomeric properties of a helical, nanotube molecular aggregate by monitoring the phase of the VSFG emission associated with different polarization configurations. By keeping track of the "phase acrobatics" associated with the added phase of the nonresonant SFG emission of gold as well as that of the double-resonance conditions achieved when the SF frequency is resonant with an electronic exciton transition, we discover that for aggregates of tetra(sulfonatophenyl)porphyrin (TSPP) the PPP-polarized spectra exhibit double-resonance conditions while SSP-polarized spectra exhibit resonance only with the ground-state vibration. Along with observed shifts in the vibrational frequency, intensity differences, and sign flips in the imaginary second-order susceptibility, χ s,Im (2) , we conclude that PPP-polarized HD-VSFG spectra reflect the delocalized, excitonic nature of the molecular aggregate, while the SSP-polarized HD-VSFG spectra measure the localized, monomeric nature of the molecular subunits. It is implied from this study that HD-VSFG spectroscopy can be uniquely utilized to measure the excitonic and monomeric properties associated with molecular assemblies for a single sample.

Cell cycle-related fluctuations in transcellular ionic currents and plasma membrane Ca2+/Mg2+ ATPase activity during early cleavages of Lymnaea stagnalis embryos.

PubMed

Zivkovic, Danica; Créton, Robbert; Dohmen, René

1991-08-01

During the first four mitotic division cycles of Lymnaea stagnalis embryos, we have detected cell cycle-dependent changes in the pattern of transcellular ionic currents and membrane-bound Ca 2+ -stimulated ATPase activity. Ionic currents ranging from 0.05 to 2.50 μA/cm 2 have been measured using the vibrating probe technique. Enzyme activity was detected using Ando's cytochemical method (Ando et al. 1981) which reveals Ca 2+ /Mg 2+ ATPase localization at the ultrastructural level, and under high-stringency conditions with respect to calcium availability, it reveals Ca 2+ -stimulated ATPase. The ionic currents and Ca 2+ -stimulated ATPase localization have in common that important changes occur during the M-phase of the cell cycles. Minimal outward current at the vegetal pole coincides with metaphase/anaphase. Maximal inward current at the animal pole coincides with the onset of cytokinesis at that pole. Ca 2+ -stimulated ATPase is absent from one half of the embryo at metaphase/anaphase of the two- and four-cell stage, whereas it is present in all cells during the remaining part of the cell cycle. Since fluctuations of cytosolic free calcium concentrations appear to correlate with both karyokinesis and cytokinesis, we speculate that part of the cyclic pattern of Ca 2+ -stimulated ATPase localization and of the transcellular ionic currents reflects the elevation of cytosolic free calcium concentration during the M-phase.

Generalized spin-wave theory: Application to the bilinear-biquadratic model

NASA Astrophysics Data System (ADS)

Muniz, Rodrigo A.; Kato, Yasuyuki; Batista, Cristian D.

2014-08-01

We present a mathematical framework for the multi-boson approach that has been used several times for treating spin systems. We demonstrate that the multi-boson approach corresponds to a generalization of the traditional spin-wave theory from SU(2) to SU(N), where N is the number of states of the local degree of freedom. Low-energy excitations are waves of the local order parameter that fluctuates in the SU(N) space of unitary transformations of the local spin states, instead of the SU(2) space of local spin rotations. Since the generators of the SU(N) group can be represented as bilinear forms in N-flavored bosons, the low-energy modes of the generalized spin-wave theory (GSWT) are described with N-1 different bosons, which provide a more accurate description of low-energy excitations even for the usual ferromagnetic and antiferromagnetic phases. The generalization enables the treatment of quantum spin systems whose ground states exhibit multipolar ordering as well as the detection of instabilities of magnetically ordered states (dipolar ordering) towards higher multipolar orderings. We illustrate the advantages of the GSWT by applying it to a bilinear-biquadratic model of arbitrary spin S on hypercubic lattices, and then analyzing the spectrum of dipolar phases in order to find their instabilities. In contrast to the known results for S=1 when the biquadratic term in the Hamiltonian is negative, we find that there is no nematic phase between the ferromagnetic or antiferromagnetic orderings for S>1.

Phase Helps Find Geometrically Optimal Gaits

NASA Astrophysics Data System (ADS)

Revzen, Shai; Hatton, Ross

Geometric motion planning describes motions of animals and machines governed by g ˙ = gA (q) q ˙ - a connection A (.) relating shape q and shape velocity q ˙ to body frame velocity g-1 g ˙ ∈ se (3) . Measuring the entire connection over a multidimensional q is often unfeasible with current experimental methods. We show how using a phase estimator can make tractable measuring the local structure of the connection surrounding a periodic motion q (φ) driven by a phase φ ∈S1 . This approach reduces the complexity of the estimation problem by a factor of dimq . The results suggest that phase estimation can be combined with geometric optimization into an iterative gait optimization algorithm usable on experimental systems, or alternatively, to allow the geometric optimality of an observed gait to be detected. ARO W911NF-14-1-0573, NSF 1462555.

MR-based source localization for MR-guided HDR brachytherapy

NASA Astrophysics Data System (ADS)

Beld, E.; Moerland, M. A.; Zijlstra, F.; Viergever, M. A.; Lagendijk, J. J. W.; Seevinck, P. R.

2018-04-01

For the purpose of MR-guided high-dose-rate (HDR) brachytherapy, a method for real-time localization of an HDR brachytherapy source was developed, which requires high spatial and temporal resolutions. MR-based localization of an HDR source serves two main aims. First, it enables real-time treatment verification by determination of the HDR source positions during treatment. Second, when using a dummy source, MR-based source localization provides an automatic detection of the source dwell positions after catheter insertion, allowing elimination of the catheter reconstruction procedure. Localization of the HDR source was conducted by simulation of the MR artifacts, followed by a phase correlation localization algorithm applied to the MR images and the simulated images, to determine the position of the HDR source in the MR images. To increase the temporal resolution of the MR acquisition, the spatial resolution was decreased, and a subpixel localization operation was introduced. Furthermore, parallel imaging (sensitivity encoding) was applied to further decrease the MR scan time. The localization method was validated by a comparison with CT, and the accuracy and precision were investigated. The results demonstrated that the described method could be used to determine the HDR source position with a high accuracy (0.4–0.6 mm) and a high precision (⩽0.1 mm), at high temporal resolutions (0.15–1.2 s per slice). This would enable real-time treatment verification as well as an automatic detection of the source dwell positions.

Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.

PubMed

Soares, Nelson C; Spät, Philipp; Krug, Karsten; Macek, Boris

2013-06-07

Recent phosphoproteomics studies have generated relatively large data sets of bacterial proteins phosphorylated on serine, threonine, and tyrosine, implicating this type of phosphorylation in the regulation of vital processes of a bacterial cell; however, most phosphoproteomics studies in bacteria were so far qualitative. Here we applied stable isotope labeling by amino acids in cell culture (SILAC) to perform a quantitative analysis of proteome and phosphoproteome dynamics of Escherichia coli during five distinct phases of growth in the minimal medium. Combining two triple-SILAC experiments, we detected a total of 2118 proteins and quantified relative dynamics of 1984 proteins in all measured phases of growth, including 570 proteins associated with cell wall and membrane. In the phosphoproteomic experiment, we detected 150 Ser/Thr/Tyr phosphorylation events, of which 108 were localized to a specific amino acid residue and 76 were quantified in all phases of growth. Clustering analysis of SILAC ratios revealed distinct sets of coregulated proteins for each analyzed phase of growth and overrepresentation of membrane proteins in transition between exponential and stationary phases. The proteomics data indicated that proteins related to stress response typically associated with the stationary phase, including RpoS-dependent proteins, had increasing levels already during earlier phases of growth. Application of SILAC enabled us to measure median occupancies of phosphorylation sites, which were generally low (<12%). Interestingly, the phosphoproteome analysis showed a global increase of protein phosphorylation levels in the late stationary phase, pointing to a likely role of this modification in later phases of growth.

Swept-frequency feedback interferometry using terahertz frequency QCLs: a method for imaging and materials analysis.

PubMed

Rakić, Aleksandar D; Taimre, Thomas; Bertling, Karl; Lim, Yah Leng; Dean, Paul; Indjin, Dragan; Ikonić, Zoran; Harrison, Paul; Valavanis, Alexander; Khanna, Suraj P; Lachab, Mohammad; Wilson, Stephen J; Linfield, Edmund H; Davies, A Giles

2013-09-23

The terahertz (THz) frequency quantum cascade laser (QCL) is a compact source of high-power radiation with a narrow intrinsic linewidth. As such, THz QCLs are extremely promising sources for applications including high-resolution spectroscopy, heterodyne detection, and coherent imaging. We exploit the remarkable phase-stability of THz QCLs to create a coherent swept-frequency delayed self-homodyning method for both imaging and materials analysis, using laser feedback interferometry. Using our scheme we obtain amplitude-like and phase-like images with minimal signal processing. We determine the physical relationship between the operating parameters of the laser under feedback and the complex refractive index of the target and demonstrate that this coherent detection method enables extraction of complex refractive indices with high accuracy. This establishes an ultimately compact and easy-to-implement THz imaging and materials analysis system, in which the local oscillator, mixer, and detector are all combined into a single laser.

RNA stores tau reversibly in complex coacervates

PubMed Central

Lin, Yanxian; Eschmann, Neil A.; Zhou, Hongjun; Rauch, Jennifer N.; Hernandez, Israel; Guzman, Elmer; Kosik, Kenneth S.; Han, Songi

2017-01-01

Nonmembrane-bound organelles that behave like liquid droplets are widespread among eukaryotic cells. Their dysregulation appears to be a critical step in several neurodegenerative conditions. Here, we report that tau protein, the primary constituent of Alzheimer neurofibrillary tangles, can form liquid droplets and therefore has the necessary biophysical properties to undergo liquid-liquid phase separation (LLPS) in cells. Consonant with the factors that induce LLPS, tau is an intrinsically disordered protein that complexes with RNA to form droplets. Uniquely, the pool of RNAs to which tau binds in living cells are tRNAs. This phase state of tau is held in an approximately 1:1 charge balance across the protein and the nucleic acid constituents, and can thus be maximal at different RNA:tau mass ratios, depending on the biopolymer constituents involved. This feature is characteristic of complex coacervation. We furthermore show that the LLPS process is directly and sensitively tuned by salt concentration and temperature, implying it is modulated by both electrostatic interactions between the involved protein and nucleic acid constituents, as well as net changes in entropy. Despite the high protein concentration within the complex coacervate phase, tau is locally freely tumbling and capable of diffusing through the droplet interior. In fact, tau in the condensed phase state does not reveal any immediate changes in local protein packing, local conformations and local protein dynamics from that of tau in the dilute solution state. In contrast, the population of aggregation-prone tau as induced by the complexation with heparin is accompanied by large changes in local tau conformations and irreversible aggregation. However, prolonged residency within the droplet state eventually results in the emergence of detectable β-sheet structures according to thioflavin-T assay. These findings suggest that the droplet state can incubate tau and predispose the protein toward the formation of insoluble fibrils. PMID:28683104

Probing the symmetry of the potential of localized surface plasmon resonances with phase-shaped electron beams.

PubMed

Guzzinati, Giulio; Béché, Armand; Lourenço-Martins, Hugo; Martin, Jérôme; Kociak, Mathieu; Verbeeck, Jo

2017-04-12

Plasmonics, the science and technology of the interaction of light with metallic objects, is fundamentally changing the way we can detect, generate and manipulate light. Although the field is progressing swiftly, thanks to the availability of nanoscale manufacturing and analysis methods, fundamental properties such as the plasmonic excitations' symmetries cannot be accessed directly, leading to a partial, sometimes incorrect, understanding of their properties. Here we overcome this limitation by deliberately shaping the wave function of an electron beam to match a plasmonic excitations' symmetry in a modified transmission electron microscope. We show experimentally and theoretically that this offers selective detection of specific plasmon modes within metallic nanoparticles, while excluding modes with other symmetries. This method resembles the widespread use of polarized light for the selective excitation of plasmon modes with the advantage of locally probing the response of individual plasmonic objects and a far wider range of symmetry selection criteria.

Modelling of physical influences in sea level records for vertical crustal movement detection

NASA Technical Reports Server (NTRS)

Anderson, E. G.

1978-01-01

Attempts to specify and evaluate such physical influences are reviewed with the intention of identifying problem areas and promising approaches. An example of linear modelling based on air/water temperatures, atmospheric pressure, river discharges, geostrophic and/or local wind velocities, and including forced period terms to allow for the long period tides and Chandlerian polar motion is evaluated and applied to monthly mean sea levels recorded in Atlantic Canada. Refinement of the model to admit phase lag in the response to some of the driving phenomena is demonstrated. Spectral analysis of the residuals is employed to assess the model performance. The results and associated statistical parameters are discussed with emphasis on elucidating the sensitivity of the technique for detection of local episodic and secular vertical crustal movements, the problem areas most critical to the type of approach, and possible further developments.

Comment on "Localized water reverberation phases and its impact on back-projection images" by Yue et al. [2017

NASA Astrophysics Data System (ADS)

Fan, W.; Shearer, P. M.

2017-12-01

Fan and Shearer [2016] analyzed the 2012 Mw 7.2 Sumatra earthquake and reported that the earthquake dynamically triggered early aftershock/aftershocks 150 km away from the mainshock and 50 s later. The early aftershock/aftershocks were detected with teleseismic P-wave back-projection, coincided with passing surface waves, and showed observable seismic waveforms in a wide frequency range (0.02—5 Hz). Recently, however, Yue et al. [2017] interpreted these coda arrivals as water reverberations from the mainshock, based mostly on EGF analysis of a nearby M6 earthquake and a water-phase synthetic test. Here, we show detailed back-projection and waveform analysis of three M6 earthquakes within 100km of the Mw 7.2 earthquake, including the EGF event analyzed in Yue et al. [2017]. In addition, we examine the waveforms of three M5.5 reverse faulting earthquakes close to our detected early aftershock landward of the trench. Our results show that the coda energy in question is more likely caused by a separate earthquake near the trench than by a mainshock water reverberation phase, thus supporting our earlier conclusion that the detected coherent radiators are likely to be dynamically triggered early aftershock/aftershocks.

A 24-GHz portable FMCW radar with continuous beam steering phased array (Conference Presentation)

NASA Astrophysics Data System (ADS)

Peng, Zhengyu; Li, Changzhi

2017-05-01

A portable 24-GHz frequency-modulated continuous-wave (FMCW) radar with continuous beam steering phased array is presented. This board-level integrated radar system consists of a phased array antenna, a radar transceiver and a baseband. The phased array used by the receiver is a 4-element linear array. The beam of the phased array can be continuously steered with a range of ±30° on the H-plane through an array of vector controllers. The vector controller is based on the concept of vector sum with binary-phase-shift attenuators. Each vector controller is capable of independently controlling the phase and the amplitude of each element of the linear array. The radar transceiver is based on the six-port technique. A free-running voltage controlled oscillator (VCO) is controlled by an analog "sawtooth" voltage generator to produce frequency-modulated chirp signal. This chirp signal is used as the transmitter signal, as well as the local oscillator (LO) signal to drive the six-port circuit. The transmitter antenna is a single patch antenna. In the baseband, the beat signal of the FMCW radar is detected by the six-port circuit and then processed by a laptop in real time. Experiments have been performed to reveal the capabilities of the proposed radar system for applications including indoor inverse synthetic aperture radar (ISAR) imaging, vital sign detection, and short-range navigation, etc. (This abstract is for the profiles session.)

Automated mitosis detection of stem cell populations in phase-contrast microscopy images.

PubMed

Huh, Seungil; Ker, Dai Fei Elmer; Bise, Ryoma; Chen, Mei; Kanade, Takeo

2011-03-01

Due to the enormous potential and impact that stem cells may have on regenerative medicine, there has been a rapidly growing interest for tools to analyze and characterize the behaviors of these cells in vitro in an automated and high throughput fashion. Among these behaviors, mitosis, or cell division, is important since stem cells proliferate and renew themselves through mitosis. However, current automated systems for measuring cell proliferation often require destructive or sacrificial methods of cell manipulation such as cell lysis or in vitro staining. In this paper, we propose an effective approach for automated mitosis detection using phase-contrast time-lapse microscopy, which is a nondestructive imaging modality, thereby allowing continuous monitoring of cells in culture. In our approach, we present a probabilistic model for event detection, which can simultaneously 1) identify spatio-temporal patch sequences that contain a mitotic event and 2) localize a birth event, defined as the time and location at which cell division is completed and two daughter cells are born. Our approach significantly outperforms previous approaches in terms of both detection accuracy and computational efficiency, when applied to multipotent C3H10T1/2 mesenchymal and C2C12 myoblastic stem cell populations.

Can single molecule localization microscopy be used to map closely spaced RGD nanodomains?

PubMed Central

Nicovich, Philip R.; Soeriyadi, Alexander; Nieves, Daniel J.; Gooding, J. Justin; Gaus, Katharina

2017-01-01

Cells sense and respond to nanoscale variations in the distribution of ligands to adhesion receptors. This makes single molecule localization microscopy (SMLM) an attractive tool to map the distribution of ligands on nanopatterned surfaces. We explore the use of SMLM spatial cluster analysis to detect nanodomains of the cell adhesion-stimulating tripeptide arginine-glycine-aspartic acid (RGD). These domains were formed by the phase separation of block copolymers with controllable spacing on the scale of tens of nanometers. We first determined the topology of the block copolymer with atomic force microscopy (AFM) and then imaged the localization of individual RGD peptides with direct stochastic optical reconstruction microscopy (dSTORM). To compare the data, we analyzed the dSTORM data with DBSCAN (density-based spatial clustering application with noise). The ligand distribution and polymer topology are not necessary identical since peptides may attach to the polymer outside the nanodomains and/or coupling and detection of peptides within the nanodomains is incomplete. We therefore performed simulations to explore the extent to which nanodomains could be mapped with dSTORM. We found that successful detection of nanodomains by dSTORM was influenced by the inter-domain spacing and the localization precision of individual fluorophores, and less by non-specific absorption of ligands to the substratum. For example, under our imaging conditions, DBSCAN identification of nanodomains spaced further than 50 nm apart was largely independent of background localisations, while nanodomains spaced closer than 50 nm required a localization precision of ~11 nm to correctly estimate the modal nearest neighbor distance (NDD) between nanodomains. We therefore conclude that SMLM is a promising technique to directly map the distribution and nanoscale organization of ligands and would benefit from an improved localization precision. PMID:28723958

One Door to the Corps: The U.S. Army Engineering and Support Center, Huntsville Historical Update, 1998-2007

DTIC Science & Technology

2009-01-01

with Transpiring Wall Reactor; and Gas Phase Chemical Reduction systems . After much study , ACWA selected three technologies for additional study ...detection systems , and hardware development. Importantly, these advancements allowed for a more effective and cost-efficient remediation process... grounds at the ASPs, the munitions contractors considered a variety of factors, including proximity to the local civilian population and potential

Pore-Scale Characterization of Biogeochemical Controls on Iron and Uranium Speciation under Flow Conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pearce, Carolyn I.; Wilkins, Michael J.; Zhang, Changyong

2012-09-17

Etched silicon microfluidic pore network models (micromodels) with controlled chemical and redox gradients, mineralogy, and microbiology under continuous flow conditions are used for the incremental development of complex microenvironments that simulate subsurface conditions. We demonstrate the colonization of micromodel pore spaces by an anaerobic Fe(III)-reducing bacterial species (Geobacter sulfurreducens) and the enzymatic reduction of a bioavailable Fe(III) phase within this environment. Using both X-ray Microprobe and X-ray Absorption Spectroscopy, we investigate the combined effects of the precipitated Fe(III) phases and the microbial population on uranium biogeochemistry under flow conditions. Precipitated Fe(III) phases within the micromodel were most effectively reduced inmore » the presence of an electron shuttle (AQDS), and Fe(II) ions adsorbed onto the precipitated mineral surface without inducing any structural change. In the absence of Fe(III), U(VI) was effectively reduced by the microbial population to insoluble U(IV), which was precipitated in discrete regions associated with biomass. In the presence of Fe(III) phases, however, both U(IV) and U(VI) could be detected associated with biomass, suggesting re-oxidation of U(IV) by localized Fe(III) phases. These results demonstrate the importance of the spatial localization of biomass and redox active metals, and illustrate the key effects of pore-scale processes on contaminant fate and reactive transport.« less

Sensitivity Enhancement of an Inductively Coupled Local Detector Using a HEMT-based Current Amplifier

PubMed Central

Qian, Chunqi; Duan, Qi; Dodd, Steve; Koretsky, Alan; Murphy-Boesch, Joe

2015-01-01

Purpose To improve the signal transmission efficiency and sensitivity of a local detection coil that is weakly inductively coupled to a larger receive coil. Methods The resonant detection coil is connected in parallel with the gate of a HEMT transistor without impedance matching. When the drain of the transistor is capacitively shunted to ground, current amplification occurs in the resonator by feedback that transforms a capacitive impedance on the transistor’s source to a negative resistance on its gate. Results High resolution images were obtained from a mouse brain using a small, 11 mm diameter surface coil that was inductively coupled to a commercial, phased array chest coil. Although the power consumption of the amplifier was only 88 µW, 14 dB gain was obtained with excellent noise performance. Conclusion An integrated current amplifier based on a High Electron Mobility Transistor (HEMT) can enhance the sensitivity of inductively coupled local detectors when weakly coupled. This amplifier enables efficient signal transmission between customized user coils and commercial clinical coils, without the need for a specialized signal interface. PMID:26192998

Electronic Griffiths phase and quantum interference in disordered heavy-fermion systems

NASA Astrophysics Data System (ADS)

Gnida, Daniel

2018-02-01

We investigated the specific heat and electrical resistivity of disordered heavy-fermion systems Ce2Co0.8Si3.2 and Ce2Co0.4Rh0.4Si3.2 . Results show that pronounced non-Fermi-liquid behavior in these Kondo disordered compounds originates from approaching metal-insulator transition rather than from proximity to magnetic instability. Power-law divergence of the local Kondo temperature distribution, P (TK) , in the limit of TK→0 , and clear signature of the quantum interference corrections in the resistivity detected deep below the onset of Kondo coherent state, point to electronic Griffiths phase formation in the studied compounds.

Adhesion characterization and defect sizing of sandwich honeycomb composites.

PubMed

Ndiaye, Elhadji Barra; Maréchal, Pierre; Duflo, Hugues

2015-09-01

Defects may appear in composite structures during their life cycle. A 10MHz 128 elements phased array transducer was investigated to characterize join bonds and defects in sandwich honeycomb composite structures. An adequate focal law throughout the composite skin gives the ultrasonic dispersive properties of the composite skin and glue layer behind. The resulting B-scan cartographies allow characterizing locally the honeycomb adhesion. Experimental measurements are compared in good agreement with the Debye Series Method (DSM). In the processed C-scan image, flaws are detectable and measurable, localized both in the scanning plane and in the thickness of the composite skin. Copyright © 2015 Elsevier B.V. All rights reserved.

Surface relief structures for multiple beam LO generation

NASA Technical Reports Server (NTRS)

Veldkamp, W. B.

1980-01-01

Linear and binary holograms for use in heterodyne detection with 10.6 micron imaging arrays are described. The devices match the amplitude and phase of the local oscillator to the received signal and thus maximize the system signal to noise ratio and resolution and minimize heat generation on the focal plane. In both the linear and binary approaches, the holographic surface-relief pattern is coded to generate a set of local oscillator beams when the relief pattern is illuminated by a single planewave. Each beam of this set has the same amplitude shape distribution as, and is collinear with, each single element wavefront illuminating array.

Determination of acidic herbicides in surface water by solid-phase extraction followed by capillary zone electrophoresis.

PubMed

Qin, Weidong; Wei, Hongping; Li, Sam Fong Yau

2002-08-01

A rapid solid-phase extraction-capillary zone electrophoresis (CZE) method for determining 2,4-dichlorophenoxyacetic acid, 4-(2,4-dichlorophenoxy) butyric acid, and 2,4,5-trichlorophenoxyacetic acid in real water samples is described. Factors affecting the recoveries and detection of the targets are investigated. With samples being acidified to pH 2 and salted by sodium sulfate to 2% (w/w), an average recovery of greater than 85% is obtained using ethyl acetate as the eluent on an octadecylsilane-bonded silica cartridge. A running buffer of 5 mM sodium tetraborate in a water-acetonitrile mixture (70:30, v/v) adjusted to pH 9 is employed in the CZE analysis, and the targets can be analyzed within 7 min with good reproducibility and acceptable sensitivity. The method is suitable for detecting herbicide residues of sub-parts-per-billion levels in surface water. A local pond water is analyzed, and the concentrations of 2,4-dichlorophenoxyacetic acid and 4-(2,4-dichlorophenoxy) butyric acid are detected to be 0.27 +/- 0.03 ppb and 0.61 +/- 0.08 ppb, respectively.

Spatiotemporal Receptive Field Properties of a Looming-Sensitive Neuron in Solitarious and Gregarious Phases of the Desert Locust

PubMed Central

Harston, George W. J.; Kilburn-Toppin, Fleur; Matheson, Thomas; Burrows, Malcolm; Gabbiani, Fabrizio; Krapp, Holger G.

2010-01-01

Desert locusts (Schistocerca gregaria) can transform reversibly between the swarming gregarious phase and a solitarious phase, which avoids other locusts. This transformation entails dramatic changes in morphology, physiology, and behavior. We have used the lobula giant movement detector (LGMD) and its postsynaptic target, the descending contralateral movement detector (DCMD), which are visual interneurons that detect looming objects, to analyze how differences in the visual ecology of the two phases are served by altered neuronal function. Solitarious locusts had larger eyes and a greater degree of binocular overlap than those of gregarious locusts. The receptive field to looming stimuli had a large central region of nearly equal response spanning 120° × 60° in both phases. The DCMDs of gregarious locusts responded more strongly than solitarious locusts and had a small caudolateral focus of even further sensitivity. More peripherally, the response was reduced in both phases, particularly ventrally, with gregarious locusts showing greater proportional decrease. Gregarious locusts showed less habituation to repeated looming stimuli along the eye equator than did solitarious locusts. By contrast, in other parts of the receptive field the degree of habituation was similar in both phases. The receptive field organization to looming stimuli contrasts strongly with the receptive field organization of the same neurons to nonlooming local-motion stimuli, which show much more pronounced regional variation. The DCMDs of both gregarious and solitarious locusts are able to detect approaching objects from across a wide expanse of visual space, but phase-specific changes in the spatiotemporal receptive field are linked to lifestyle changes. PMID:19955292

Evaluation of the Performance of the Distributed Phased-MIMO Sonar.

PubMed

Pan, Xiang; Jiang, Jingning; Wang, Nan

2017-01-11

A broadband signal model is proposed for a distributed multiple-input multiple-output (MIMO) sonar system consisting of two transmitters and a receiving linear array. Transmitters are widely separated to illuminate the different aspects of an extended target of interest. The beamforming technique is utilized at the reception ends for enhancement of weak target echoes. A MIMO detector is designed with the estimated target position parameters within the general likelihood rate test (GLRT) framework. For the high signal-to-noise ratio case, the detection performance of the MIMO system is better than that of the phased-array system in the numerical simulations and the tank experiments. The robustness of the distributed phased-MIMO sonar system is further demonstrated in localization of a target in at-lake experiments.

Evaluation of the Performance of the Distributed Phased-MIMO Sonar

PubMed Central

Pan, Xiang; Jiang, Jingning; Wang, Nan

2017-01-01

A broadband signal model is proposed for a distributed multiple-input multiple-output (MIMO) sonar system consisting of two transmitters and a receiving linear array. Transmitters are widely separated to illuminate the different aspects of an extended target of interest. The beamforming technique is utilized at the reception ends for enhancement of weak target echoes. A MIMO detector is designed with the estimated target position parameters within the general likelihood rate test (GLRT) framework. For the high signal-to-noise ratio case, the detection performance of the MIMO system is better than that of the phased-array system in the numerical simulations and the tank experiments. The robustness of the distributed phased-MIMO sonar system is further demonstrated in localization of a target in at-lake experiments. PMID:28085071

Local symmetric distortion boosted photon up-conversion and thermometric sensitivity in lanthanum oxide nanospheres.

PubMed

Suo, Hao; Zhao, Xiaoqi; Zhang, Zhiyu; Shi, Rui; Wu, Yanfang; Xiang, Jinmeng; Guo, Chongfeng

2018-05-17

It is essential to simultaneously boost the luminescence intensity and thermometric sensitivity of up-converted optical thermometers towards potential biomedical sensing applications. Herein, the effects of local site symmetry on the up-conversion (UC) emission and thermal sensing ability in trigonal-phased La2O3:Er3+/Yb3+ nanospheres were qualitatively explored using cubic-phased Lu2O3 and Y2O3 with a similar shape and phonon energy as contrasts. Under 980 nm light excitation, much stronger UC emissions were detected in La2O3 samples than that in cubic Lu2O3 and Y2O3 samples, and the possible mechanisms were elaborately proposed using Eu3+ as a luminescent probe. Thermo-responsive emission intensity from 2H11/2/4S3/2 levels was monitored to evaluate the absolute sensitivity of three samples, which strongly depends on the dopant-induced local site symmetric distortions according to the Judd-Ofelt theory. The potentiality of La2O3:Er3+/Yb3+ for sub-tissue thermometry was also validated by ex vivo experiments. Results open a promising avenue for realizing highly sensitive thermometry with a large signal-to-noise ratio in sub-tissues via finely tailoring the local site symmetry.

Smart CMOS image sensor for lightning detection and imaging.

PubMed

Rolando, Sébastien; Goiffon, Vincent; Magnan, Pierre; Corbière, Franck; Molina, Romain; Tulet, Michel; Bréart-de-Boisanger, Michel; Saint-Pé, Olivier; Guiry, Saïprasad; Larnaudie, Franck; Leone, Bruno; Perez-Cuevas, Leticia; Zayer, Igor

2013-03-01

We present a CMOS image sensor dedicated to lightning detection and imaging. The detector has been designed to evaluate the potentiality of an on-chip lightning detection solution based on a smart sensor. This evaluation is performed in the frame of the predevelopment phase of the lightning detector that will be implemented in the Meteosat Third Generation Imager satellite for the European Space Agency. The lightning detection process is performed by a smart detector combining an in-pixel frame-to-frame difference comparison with an adjustable threshold and on-chip digital processing allowing an efficient localization of a faint lightning pulse on the entire large format array at a frequency of 1 kHz. A CMOS prototype sensor with a 256×256 pixel array and a 60 μm pixel pitch has been fabricated using a 0.35 μm 2P 5M technology and tested to validate the selected detection approach.

Coherent detection of position errors in inter-satellite laser communications

NASA Astrophysics Data System (ADS)

Xu, Nan; Liu, Liren; Liu, De'an; Sun, Jianfeng; Luan, Zhu

2007-09-01

Due to the improved receiver sensitivity and wavelength selectivity, coherent detection became an attractive alternative to direct detection in inter-satellite laser communications. A novel method to coherent detection of position errors information is proposed. Coherent communication system generally consists of receive telescope, local oscillator, optical hybrid, photoelectric detector and optical phase lock loop (OPLL). Based on the system composing, this method adds CCD and computer as position error detector. CCD captures interference pattern while detection of transmission data from the transmitter laser. After processed and analyzed by computer, target position information is obtained from characteristic parameter of the interference pattern. The position errors as the control signal of PAT subsystem drive the receiver telescope to keep tracking to the target. Theoretical deviation and analysis is presented. The application extends to coherent laser rang finder, in which object distance and position information can be obtained simultaneously.

Chemical and explosive detections using photo-acoustic effect and quantum cascade lasers

NASA Astrophysics Data System (ADS)

Choa, Fow-Sen

2013-12-01

Photoacoustic (PA) effect is a sensitive spectroscopic technique for chemical sensing. In recent years, with the development of quantum cascade lasers (QCLs), significant progress has been achieved for PA sensing applications. Using high-power, tunable mid-IR QCLs as laser sources, PA chemical sensor systems have demonstrated parts-pertrillion- level detection sensitivity. Many of these high sensitivity measurements were demonstrated locally in PA cells. Recently, we have demonstrated standoff PA detection of isopropanol vapor for more than 41 feet distance using a quantum cascade laser and a microphone with acoustic reflectors. We also further demonstrated solid phase TNT detections at a standoff distance of 8 feet. To further calibrate the detection sensitivity, we use nerve gas simulants that were generated and calibrated by a commercial vapor generator. Standoff detection of gas samples with calibrated concentration of 2.3 ppm was achieved at a detection distance of more than 2 feet. An extended detection distance up to 14 feet was observed for a higher gas concentration of 13.9 ppm. For field operations, array of microphones and microphone-reflector pairs can be utilized to achieve noise rejection and signal enhancement. We have experimentally demonstrated that the signal and noise spectra of the 4 microphone/4 reflector system with a combined SNR of 12.48 dB. For the 16-microphone and one reflector case, an SNR of 17.82 was achieved. These successful chemical sensing demonstrations will likely create new demands for widely tunable QCLs with ultralow threshold (for local fire-alarm size detection systems) and high-power (for standoff detection systems) performances.

Immunohistochemical characterization of the arcuate kisspeptin/neurokinin B/dynorphin (KNDy) and preoptic kisspeptin neuronal populations in the hypothalamus during the estrous cycle in heifers

PubMed Central

HASSANEEN, A; NANIWA, Yousuke; SUETOMI, Yuta; MATSUYAMA, Shuichi; KIMURA, Koji; IEDA, Nahoko; INOUE, Naoko; UENOYAMA, Yoshihisa; TSUKAMURA, Hiroko; MAEDA, Kei-ichiro; MATSUDA, Fuko; OHKURA, Satoshi

2016-01-01

Elucidating the physiological mechanisms that control reproduction is an obvious strategy for improving the fertility of cattle and developing new agents to control reproductive functions. The present study aimed to identify kisspeptin neurons in the bovine hypothalamus, clarifying that a central mechanism is also present in the cattle brain, as kisspeptin is known to play an important role in the stimulation of gonadotropin-releasing hormone (GnRH)/gonadotropin secretion in other mammals. To characterize kisspeptin neurons in the bovine hypothalamus, the co-localizations of kisspeptin and neurokinin B (NKB) or kisspeptin and dynorphin A (Dyn) were examined. Hypothalamic tissue was collected from Japanese Black or Japanese Black × Holstein crossbred cows during the follicular and luteal phases. Brain sections, including the arcuate nucleus (ARC) and the preoptic area (POA), were dual immunostained with kisspeptin and either NKB or Dyn. In the ARC, both NKB and Dyn were co-localized in kisspeptin neurons during both the follicular and luteal phases, demonstrating the presence of kisspeptin/NKB/Dyn-containing neurons, referred to as KNDy neurons, in cows. In the POA, no co-localization of kisspeptin with either NKB or Dyn was detected. Kisspeptin expression in the follicular phase was higher than that in the luteal phase, suggesting that kisspeptin expression in the POA is positively controlled by estrogen in cows. The kisspeptin neuronal populations in the ARC and POA likely play important roles in regulating the GnRH pulse and surge, respectively, in cows. PMID:27349533

VLF remote sensing of the ambient and modified lower ionosphere

NASA Astrophysics Data System (ADS)

Demirkol, Mehmet Kursad

2000-08-01

Electron density and temperature changes in the D region are sensitively manifested as changes in the amplitude and phase of subionospheric Very Low Frequency (VLF) signals propagating beneath the perturbed region. Both localized and large scale disturbances (either in electron density or temperature) in the D region cause significant scattering of VLF waves propagating in the earth- ionosphere waveguide, leading to measurable changes in the amplitude and phase of the VLF waves. Large scale auroral disturbances, associated with intensification of the auroral electrojet, as well as ionospheric disturbances produced during relativistic electron enhancements, cause characteristic changes over relatively long time scales that allow the assessment of the `ambient' ionosphere. Localized ionospheric disturbances are also produced by powerful VLF transmitting facilities such as the High Power Auroral Stimulation (HIPAS) facility, the High frequency Active Auroral Research Program (HAARP), and also by lightning discharges. Amplitude and phase changes of VLF waveguide signals scattered from such artificially heated ionospheric patches are known to be detectable. In this study, we describe a new inversion algorithm to determine altitude profiles of electron density and collision frequency within such a localized disturbance by using the measured amplitude and phase of three different VLF signals at three separate receiving sites. For this purpose a new optimization algorithm is developed which is primarily based on the recursive usage of the three dimensional version of the Long Wave Propagation, Capability (LWPC) code used to model the subionospheric propagation and scattering of VLF signals in the earth- ionosphere waveguide in the presence of ionospheric disturbances.

Surface charge sensing by altering the phase transition in VO2

NASA Astrophysics Data System (ADS)

Kumar, S.; Esfandyarpour, R.; Davis, R.; Nishi, Y.

2014-08-01

Detection of surface charges has various applications in medicine, electronics, biotechnology, etc. The source of surface charge induction may range from simple charge-polarized molecules like water to complicated proteins. It was recently discovered that surface charge accumulation can alter the temperature at which VO2 undergoes a Mott transition. Here, we deposited polar molecules onto the surface of two-terminal thin-film VO2 lateral devices and monitored the joule-heating-driven Mott transition, or conductance switching. We observed that the power required to induce the conductance switching reduced upon treatment with polar molecules and, using in-situ blackbody-emission direct measurement of local temperature, we show that this reduction in power was accompanied by reduction in the Mott transition temperature. Further evidence suggested that this effect has specificity to the nature of the species used to induce surface charges. Using x-ray absorption spectroscopy, we also show that there is no detectable change in oxidation state of vanadium or structural phase in the bulk of the 40 nm VO2 thin-film even as the phase transition temperature is reduced by up to 20 K by the polar molecules. The ability to alter the phase transition parameters by depositing polar molecules suggests a potential application in sensing surface charges of different origins and this set of results also highlights interesting aspects of the phase transition in VO2.

Robust speaker's location detection in a vehicle environment using GMM models.

PubMed

Hu, Jwu-Sheng; Cheng, Chieh-Cheng; Liu, Wei-Han

2006-04-01

Abstract-Human-computer interaction (HCI) using speech communication is becoming increasingly important, especially in driving where safety is the primary concern. Knowing the speaker's location (i.e., speaker localization) not only improves the enhancement results of a corrupted signal, but also provides assistance to speaker identification. Since conventional speech localization algorithms suffer from the uncertainties of environmental complexity and noise, as well as from the microphone mismatch problem, they are frequently not robust in practice. Without a high reliability, the acceptance of speech-based HCI would never be realized. This work presents a novel speaker's location detection method and demonstrates high accuracy within a vehicle cabinet using a single linear microphone array. The proposed approach utilize Gaussian mixture models (GMM) to model the distributions of the phase differences among the microphones caused by the complex characteristic of room acoustic and microphone mismatch. The model can be applied both in near-field and far-field situations in a noisy environment. The individual Gaussian component of a GMM represents some general location-dependent but content and speaker-independent phase difference distributions. Moreover, the scheme performs well not only in nonline-of-sight cases, but also when the speakers are aligned toward the microphone array but at difference distances from it. This strong performance can be achieved by exploiting the fact that the phase difference distributions at different locations are distinguishable in the environment of a car. The experimental results also show that the proposed method outperforms the conventional multiple signal classification method (MUSIC) technique at various SNRs.

Sporadic incidence of Fascioliasis detected during Hepatobiliary procedures: A study of 18 patients from Sulaimaniyah governorate

PubMed Central

2012-01-01

Background Fascioliasis is an often-neglected zoonotic disease and currently is an emerging infection in Iraq. Fascioliasis has two distinct phases, an acute phase, exhibiting the hepatic migratory stage of the fluke’s life cycle, and a chronic biliary phase manifested with the presence of the parasite in the bile ducts through hepatic tissue. The incidence of Fascioliasis in Sulaimaniyah governorate was unexpected observation. We believe that shedding light on this disease in our locality will increase our physician awareness and experience in early detection, treatment in order to avoid unnecessary surgeries. Findings We retrospectively evaluated this disease in terms of the demographic features, clinical presentations, and managements by reviewing the medical records of 18 patients, who were admitted to the Sulaimani Teaching Hospital and Kurdistan Centre for Gastroenterology and Hepatology. Patients were complained from hepatobiliary and/or upper gastrointestinal symptoms and diagnosed accidentally with Fascioliasis during hepatobiliary surgeries and ERCP by direct visualization of the flukes and stone analysis. Elevated liver enzymes, white blood cells count and eosinophilia were notable laboratory indices. The dilated CBD, gallstones, liver cysts and abscess were found common in radiological images. Fascioliasis diagnosed during conventional surgical CBD exploration and choledochodoudenostomy, open cholecystectomy, surgical drainage of liver abscess, ERCP and during gallstone analysis. Conclusion Fascioliasis is indeed an emerging disease in our locality, but it is often underestimated and ignored. We recommend the differential diagnosis of patients suffering from Rt. Hypochondrial pain, fever and eosinophilia. The watercress ingestion was a common factor in patient’s history. PMID:23259859

Anthropogenic Organic Compounds in Ground Water and Finished Water of Community Water Systems in the Northern Tampa Bay Area, Florida, 2002-04

USGS Publications Warehouse

Metz, Patricia A.; Delzer, Gregory C.; Berndt, Marian P.; Crandall, Christy A.; Toccalino, Patricia L.

2007-01-01

As part of the U.S. Geological Survey's (USGS's) National Water-Quality Assessment (NAWQA) Program, a Source Water-Quality Assessment (SWQA) was conducted in the unconfined and semiconfined portions of the Upper Floridan aquifer system during 2002-04. SWQAs are two-phased sampling activities, wherein phase 1 was designed to evaluate the occurrence of 258 anthropogenic organic compounds (AOCs) in ground water used as source water for 30 of the largest-producing community water system (CWS) wells in the northern Tampa Bay area, Florida. The 258 AOCs included volatile organic compounds (VOCs), pesticides, and other anthropogenic organic compounds (OAOCs). Phase 2 was designed to monitor concentrations in the source water and also the finished water of CWSs for compounds most frequently detected during phase 1. During phase 1 of the SWQA study, 31 of the 258 AOCs were detected in source-water samples collected from CWS wells at low concentrations (less than 1.0 microgram per liter (ug/L)). Twelve AOCs were detected in at least 10 percent of samples. Concentrations from 16 of the 31 detected AOCs were about 2 to 5 orders of magnitude below human-health benchmarks indicating that concentrations were unlikely to be of potential human-health concern. The potential human-health relevance for the remaining 15 detected unregulated AOCs could not be evaluated because no human-health benchmarks were available for these compounds. Hydrogeology, population, and land use were examined to evaluate the effects of these variables on the source water monitored. Approximately three times as many detections of VOCs (27) and pesticides (34) occurred in unconfined areas than in the semiconfined areas (8 VOCs, 14 pesticides). In contrast, 1 OAOC was detected in unconfined areas, and 13 OAOCs were detected in semiconfined areas with 9 of the OAOC detections occurring in samples from two wells located near septic systems. Analyses of population and land use indicated that the number of compounds detected increased as the population surrounding each well increased. Detection frequencies and concentrations for VOCs (particularly chloroform) and pesticides were highest in residential land-use areas. The results of source-water samples from the 30 CWS wells monitored during phase 1 of this SWQA study were compared to four locally conducted studies. These general comparisons indicate that the occurrence of VOCs in other studies is similar to their occurrence in source water of CWSs monitored as part of this SWQA. However, pesticide compounds, especially atrazine and its breakdown products, occurred more frequently in the SWQA study than in the other four studies. Phase 2 of the SWQA assessed AOCs in samples from 11 of the 30 CWS wells and the associated finished water. Overall, 42 AOCs were detected in either source water or finished water and more compounds were detected in finished water than in source water. Specifically, 22 individual AOCs were detected in source water and 27 AOCs were detected in finished water. The total number of detections was greater in the finished water (80) than in the source water (49); however, this was largely due to the creation of disinfection by-products (DBPs) during water treatment. Excluding DBPs, about the same number of total detections was observed in source water (40) and finished water (44). During phase 2, AOC detected concentrations ranged from E0.003 (estimated) to 1,140 ug/L in the source water and from E0.003 to 36.3 ug/L in the finished water. Concentrations of 24 of the 42 compounds were compared to human-health benchmarks and were about 1 to 5 orders of magnitude below their human-health benchmarks indicating that concentrations are unlikely to be of potential human-health concern, excluding DBPs. Concentrations of carbon tetrachloride, however, were within 10 percent of its human-health benchmark, which is considered a level that may warrant inclusion of the compound in a low-concentration, t

Using multi-scale entropy and principal component analysis to monitor gears degradation via the motor current signature analysis

NASA Astrophysics Data System (ADS)

Aouabdi, Salim; Taibi, Mahmoud; Bouras, Slimane; Boutasseta, Nadir

2017-06-01

This paper describes an approach for identifying localized gear tooth defects, such as pitting, using phase currents measured from an induction machine driving the gearbox. A new tool of anomaly detection based on multi-scale entropy (MSE) algorithm SampEn which allows correlations in signals to be identified over multiple time scales. The motor current signature analysis (MCSA) in conjunction with principal component analysis (PCA) and the comparison of observed values with those predicted from a model built using nominally healthy data. The Simulation results show that the proposed method is able to detect gear tooth pitting in current signals.

Constructing local integrals of motion in the many-body localized phase

NASA Astrophysics Data System (ADS)

Chandran, Anushya; Kim, Isaac H.; Vidal, Guifre; Abanin, Dmitry A.

2015-02-01

Many-body localization provides a generic mechanism of ergodicity breaking in quantum systems. In contrast to conventional ergodic systems, many-body-localized (MBL) systems are characterized by extensively many local integrals of motion (LIOM), which underlie the absence of transport and thermalization in these systems. Here we report a physically motivated construction of local integrals of motion in the MBL phase. We show that any local operator (e.g., a local particle number or a spin-flip operator), evolved with the system's Hamiltonian and averaged over time, becomes a LIOM in the MBL phase. Such operators have a clear physical meaning, describing the response of the MBL system to a local perturbation. In particular, when a local operator represents a density of some globally conserved quantity, the corresponding LIOM describes how this conserved quantity propagates through the MBL phase. Being uniquely defined and experimentally measurable, these LIOMs provide a natural tool for characterizing the properties of the MBL phase, in both experiments and numerical simulations. We demonstrate the latter by numerically constructing an extensive set of LIOMs in the MBL phase of a disordered spin-chain model. We show that the resulting LIOMs are quasilocal and use their decay to extract the localization length and establish the location of the transition between the MBL and ergodic phases.

Accurate means of detecting and characterizing abnormal patterns of ventricular activation by phase image analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Botvinick, E.H.; Frais, M.A.; Shosa, D.W.

1982-08-01

The ability of scintigraphic phase image analysis to characterize patterns of abnormal ventricular activation was investigated. The pattern of phase distribution and sequential phase changes over both right and left ventricular regions of interest were evaluated in 16 patients with normal electrical activation and wall motion and compared with those in 8 patients with an artificial pacemaker and 4 patients with sinus rhythm with the Wolff-Parkinson-White syndrome and delta waves. Normally, the site of earliest phase angle was seen at the base of the interventricular septum, with sequential change affecting the body of the septum and the cardiac apex andmore » then spreading laterally to involve the body of both ventricles. The site of earliest phase angle was located at the apex of the right ventricle in seven patients with a right ventricular endocardial pacemaker and on the lateral left ventricular wall in one patient with a left ventricular epicardial pacemaker. In each case the site corresponded exactly to the position of the pacing electrode as seen on posteroanterior and left lateral chest X-ray films, and sequential phase changes spread from the initial focus to affect both ventricles. In each of the patients with the Wolff-Parkinson-White syndrome, the site of earliest ventricular phase angle was located, and it corresponded exactly to the site of the bypass tract as determined by endocardial mapping. In this way, four bypass pathways, two posterior left paraseptal, one left lateral and one right lateral, were correctly localized scintigraphically. On the basis of the sequence of mechanical contraction, phase image analysis provides an accurate noninvasive method of detecting abnormal foci of ventricular activation.« less

A Matched Field Processing Framework for Coherent Detection Over Local and Regional Networks

DTIC Science & Technology

2011-06-01

Northern Finland Seismological Network, FN) and to the University of Helsinki for data from the VRF and HEF stations (part of the Finnish seismograph ...shows the results of classification with the FK measurement . Most of the events are incorrectly assigned to one particular mine (K2 – Rasvumchorr...generalization of the single-phase matched field processing method that encodes the full structure of the entire wavefield? What would this

A matrix solid-phase dispersion method for the extraction of seven pesticides from mango and papaya.

PubMed

Navickiene, Sandro; Aquino, Adriano; Bezerra, Débora Santos Silva

2010-10-01

A simple and effective extraction method based on matrix solid-phase dispersion was developed to determine trichlorfon, pyrimethanil, methyl parathion, tetraconazole, thiabendazole, imazalil, and tebuconazole in papaya and mango using gas chromatography-mass spectrometry with selected ion monitoring. Different parameters of the method were evaluated, such as type of solid-phase (silica-gel, neutral alumina, and Florisil), the amount of solid-phase, and eluent [dichloromethane, ethyl acetate-dichloromethane (4:1, 1:4, 1:1, 2:3, v/v)]. The best results were obtained using 2.0 g of mango or papaya, 3.0 g of silica as dispersant sorbent, and ethyl acetate-dichloromethane (1:1, v/v) as eluting solvent. The method was validated using mango and papaya samples fortified with pesticides at different concentration levels (0.05, 0.10, and 1.0 mg/kg). Average recoveries (4 replicates) ranged from 80% to 146%, with relative standard deviations between 1.0% and 28%. Detection and quantification limits for mango and papaya ranged from 0.01 to 0.03 mg/kg and 0.05 to 0.10 mg/kg, respectively. The proposed method was applied to the analysis of these compounds in commercial fruit samples from a local market (Aracaju/SE, Brazil), and residues of the pesticides were not detected on the samples.

Auto Correlation Analysis of Coda Waves from Local Earthquakes for Detecting Temporal Changes in Shallow Subsurface Structures: the 2011 Tohoku-Oki, Japan Earthquake

NASA Astrophysics Data System (ADS)

Nakahara, Hisashi

2015-02-01

For monitoring temporal changes in subsurface structures I propose to use auto correlation functions of coda waves from local earthquakes recorded at surface receivers, which probably contain more body waves than surface waves. Use of coda waves requires earthquakes resulting in decreased time resolution for monitoring. Nonetheless, it may be possible to monitor subsurface structures in sufficient time resolutions in regions with high seismicity. In studying the 2011 Tohoku-Oki, Japan earthquake (Mw 9.0), for which velocity changes have been previously reported, I try to validate the method. KiK-net stations in northern Honshu are used in this analysis. For each moderate earthquake normalized auto correlation functions of surface records are stacked with respect to time windows in the S-wave coda. Aligning the stacked, normalized auto correlation functions with time, I search for changes in phases arrival times. The phases at lag times of <1 s are studied because changes at shallow depths are focused. Temporal variations in the arrival times are measured at the stations based on the stretching method. Clear phase delays are found to be associated with the mainshock and to gradually recover with time. The amounts of the phase delays are 10 % on average with the maximum of about 50 % at some stations. The deconvolution analysis using surface and subsurface records at the same stations is conducted for validation. The results show the phase delays from the deconvolution analysis are slightly smaller than those from the auto correlation analysis, which implies that the phases on the auto correlations are caused by larger velocity changes at shallower depths. The auto correlation analysis seems to have an accuracy of about several percent, which is much larger than methods using earthquake doublets and borehole array data. So this analysis might be applicable in detecting larger changes. In spite of these disadvantages, this analysis is still attractive because it can be applied to many records on the surface in regions where no boreholes are available.

A Two-Phase Time Synchronization-Free Localization Algorithm for Underwater Sensor Networks.

PubMed

Luo, Junhai; Fan, Liying

2017-03-30

Underwater Sensor Networks (UWSNs) can enable a broad range of applications such as resource monitoring, disaster prevention, and navigation-assistance. Sensor nodes location in UWSNs is an especially relevant topic. Global Positioning System (GPS) information is not suitable for use in UWSNs because of the underwater propagation problems. Hence, some localization algorithms based on the precise time synchronization between sensor nodes that have been proposed for UWSNs are not feasible. In this paper, we propose a localization algorithm called Two-Phase Time Synchronization-Free Localization Algorithm (TP-TSFLA). TP-TSFLA contains two phases, namely, range-based estimation phase and range-free evaluation phase. In the first phase, we address a time synchronization-free localization scheme based on the Particle Swarm Optimization (PSO) algorithm to obtain the coordinates of the unknown sensor nodes. In the second phase, we propose a Circle-based Range-Free Localization Algorithm (CRFLA) to locate the unlocalized sensor nodes which cannot obtain the location information through the first phase. In the second phase, sensor nodes which are localized in the first phase act as the new anchor nodes to help realize localization. Hence, in this algorithm, we use a small number of mobile beacons to help obtain the location information without any other anchor nodes. Besides, to improve the precision of the range-free method, an extension of CRFLA achieved by designing a coordinate adjustment scheme is updated. The simulation results show that TP-TSFLA can achieve a relative high localization ratio without time synchronization.

A Two-Phase Time Synchronization-Free Localization Algorithm for Underwater Sensor Networks

PubMed Central

Luo, Junhai; Fan, Liying

2017-01-01

Underwater Sensor Networks (UWSNs) can enable a broad range of applications such as resource monitoring, disaster prevention, and navigation-assistance. Sensor nodes location in UWSNs is an especially relevant topic. Global Positioning System (GPS) information is not suitable for use in UWSNs because of the underwater propagation problems. Hence, some localization algorithms based on the precise time synchronization between sensor nodes that have been proposed for UWSNs are not feasible. In this paper, we propose a localization algorithm called Two-Phase Time Synchronization-Free Localization Algorithm (TP-TSFLA). TP-TSFLA contains two phases, namely, range-based estimation phase and range-free evaluation phase. In the first phase, we address a time synchronization-free localization scheme based on the Particle Swarm Optimization (PSO) algorithm to obtain the coordinates of the unknown sensor nodes. In the second phase, we propose a Circle-based Range-Free Localization Algorithm (CRFLA) to locate the unlocalized sensor nodes which cannot obtain the location information through the first phase. In the second phase, sensor nodes which are localized in the first phase act as the new anchor nodes to help realize localization. Hence, in this algorithm, we use a small number of mobile beacons to help obtain the location information without any other anchor nodes. Besides, to improve the precision of the range-free method, an extension of CRFLA achieved by designing a coordinate adjustment scheme is updated. The simulation results show that TP-TSFLA can achieve a relative high localization ratio without time synchronization. PMID:28358342

μ-'Diving suit' for liquid-phase high-Q resonant detection.

PubMed

Yu, Haitao; Chen, Ying; Xu, Pengcheng; Xu, Tiegang; Bao, Yuyang; Li, Xinxin

2016-03-07

A resonant cantilever sensor is, for the first time, dressed in a water-proof 'diving suit' for real-time bio/chemical detection in liquid. The μ-'diving suit' technology can effectively avoid not only unsustainable resonance due to heavy liquid-damping, but also inevitable nonspecific adsorption on the cantilever body. Such a novel technology ensures long-time high-Q resonance of the cantilever in solution environment for real-time trace-concentration bio/chemical detection and analysis. After the formation of the integrated resonant micro-cantilever, a patterned photoresist and hydrophobic parylene thin-film are sequentially formed on top of the cantilever as sacrificial layer and water-proof coat, respectively. After sacrificial-layer release, an air gap is formed between the parylene coat and the cantilever to protect the resonant cantilever from heavy liquid damping effect. Only a small sensing-pool area, located at the cantilever free-end and locally coated with specific sensing-material, is exposed to the liquid analyte for gravimetric detection. The specifically adsorbed analyte mass can be real-time detected by recording the frequency-shift signal. In order to secure vibration movement of the cantilever and, simultaneously, reject liquid leakage from the sensing-pool region, a hydrophobic parylene made narrow slit structure is designed surrounding the sensing-pool. The anti-leakage effect of the narrow slit and damping limited resonance Q-factor are modelled and optimally designed. Integrated with electro-thermal resonance excitation and piezoresistive frequency readout, the cantilever is embedded in a micro-fluidic chip to form a lab-chip micro-system for liquid-phase bio/chemical detection. Experimental results show the Q-factor of 23 in water and longer than 20 hours liquid-phase continuous working time. Loaded with two kinds of sensing-materials at the sensing-pools, two types of sensing chips successfully show real-time liquid-phase detection to ppb-level organophosphorous pesticide of acephate and E.coli DH5α in PBS, respectively. The proposed method fundamentally solves the long-standing problem of being unable to operate a resonant micro-sensor in liquid well.

Abundance and Localization of Progesterone Receptor Isoforms in Endometrium in Women With and Without Endometriosis and in Peritoneal and Ovarian Endometriotic Implants

PubMed Central

Bedaiwy, Mohamed A.; Dahoud, Wissam; Skomorovska-Prokvolit, Yelena; Yi, Lijuan; Liu, James H.; Falcone, Tommaso; Hurd, William W.; Mesiano, Sam

2015-01-01

Background: Several studies suggest that resistance to progesterone may contribute to the pathophysiology of endometriosis. Progesterone mediates its biological activity via the 2 progesterone receptor (PR) isoforms (PR-A and PR-B). Effects of progesterone are determined by the PR-A:PR-B ratio such that a PR-B-dominant state promotes progesterone signaling, whereas a PR-A-dominant state decreases progesterone responsiveness. Our objective was to compare the abundance and cellular localization of the PR isoforms in endometrium and endometriotic lesions from women with and without peritoneal and ovarian endometriosis. Methods: This in vitro study was conducted in a tertiary care facility. Reproductive-age women with surgically diagnosed endometriosis (n = 18) and asymptomatic control individuals (n = 20) were prospectively recruited at the late proliferative and the early secretory phases. At laparoscopy, samples of eutopic endometrium, peritoneal and ovarian endometriosis, and disease-free peritoneum were obtained for subsequent immunohistochemical and immunoblot analysis of PR-B and total PR localization and PR-A and PR-B abundance, respectively. Results: The PR-A and PR-B were detected in eutopic endometrium and in peritoneal and ovarian endometriosis but not in disease-free peritoneum from patients with and without endometriosis. In peritoneal endometriosis, PR-A was the predominant isoform detected, whereas both receptors were detected in ovarian endometriosis and eutopic endometrium. In eutopic endometrium, levels of PR-A were significantly elevated in women with endometriosis compared with women without disease, regardless of menstrual phase. The PR-A levels were significantly elevated in ovarian endometriosis compared with peritoneal endometriosis. Conclusions: Endometriotic lesions and eutopic endometrium from women with endometriosis are uniform in a PR-A-dominant state. The data suggest that menstrual efflux of a PR-A-dominant endometrial tissue into the peritoneal cavity may play a role in the pathophysiology of endometriosis. PMID:26037298

In Vivo Detection of 15N-Coupled Protons in Rat Brain by ISIS Localization and Multiple-Quantum Editing

NASA Astrophysics Data System (ADS)

Kanamori, Keiko; Ross, Brian D.

1999-08-01

Three-dimensional image-selected in vivo spectroscopy (ISIS) was combined with phase-cycled 1H-15N heteronuclear multiple-quantum coherence (HMQC) transfer NMR for localized selective observation of protons J-coupled to 15N in phantoms and in vivo. The ISIS-HMQC sequence, supplemented by jump-return water suppression, permitted localized selective observation of 2-5 μmol of [15Nindole]tryptophan, a precursor of the neurotransmitter serotonin, through the 15N-coupled proton in 20-40 min of acquisition in vitro at 4.7 T. In vivo, the amide proton of [5-15N]glutamine was selectively observed in the brain of spontaneously breathing 15NH4+-infused rats, using a volume probe with homogeneous 1H and 15N fields. Signal recovery after three-dimensional localization was 72-82% in phantoms and 59 ± 4% in vivo. The result demonstrates that localized selective observation of 15N-coupled protons, with complete cancellation of all other protons except water, can be achieved in spontaneously breathing animals by the ISIS-HMQC sequence. This sequence performs both volume selection and heteronuclear editing through an addition/subtraction scheme and predicts the highest intrinsic sensitivity for detection of 15N-coupled protons in the selected volume. The advantages and limitations of this method for in vivo application are compared to those of other localized editing techniques currently in use for non-exchanging protons.

Multiscale tomography of buried magnetic structures: its use in the localization and characterization of archaeological structures

NASA Astrophysics Data System (ADS)

Saracco, Ginette; Moreau, Frédérique; Mathé, Pierre-Etienne; Hermitte, Daniel; Michel, Jean-Marie

2007-10-01

We have previously developed a method for characterizing and localizing `homogeneous' buried sources, from the measure of potential anomalies at a fixed height above ground (magnetic, electric and gravity). This method is based on potential theory and uses the properties of the Poisson kernel (real by definition) and the continuous wavelet theory. Here, we relax the assumption on sources and introduce a method that we call the `multiscale tomography'. Our approach is based on the harmonic extension of the observed magnetic field to produce a complex source by use of a complex Poisson kernel solution of the Laplace equation for complex potential field. A phase and modulus are defined. We show that the phase provides additional information on the total magnetic inclination and the structure of sources, while the modulus allows us to characterize its spatial location, depth and `effective degree'. This method is compared to the `complex dipolar tomography', extension of the Patella method that we previously developed. We applied both methods and a classical electrical resistivity tomography to detect and localize buried archaeological structures like antique ovens from magnetic measurements on the Fox-Amphoux site (France). The estimates are then compared with the results of excavations.

A constructive nonlinear array (CNA) method for barely visible impact detection in composite materials

NASA Astrophysics Data System (ADS)

Malfense Fierro, Gian Piero; Meo, Michele

2017-04-01

Currently there are numerous phased array techniques such as Full Matrix Capture (FMC) and Total Focusing Method (TFM) that provide good damage assessment for composite materials. Although, linear methods struggle to evaluate and assess low levels of damage, while nonlinear methods have shown great promise in early damage detection. A sweep and subtraction evaluation method coupled with a constructive nonlinear array method (CNA) is proposed in order to assess damage specific nonlinearities, address issues with frequency selection when using nonlinear ultrasound imaging techniques and reduce equipment generated nonlinearities. These methods were evaluated using multiple excitation locations on an impacted composite panel with a complex damage (barely visible impact damage). According to various recent works, damage excitation can be accentuated by exciting at local defect resonance (LDR) frequencies; although these frequencies are not always easily determinable. The sweep methodology uses broadband excitation to determine both local defect and material resonances, by assessing local defect generated nonlinearities using a laser vibrometer it is possible to assess which frequencies excite the complex geometry of the crack. The dual effect of accurately determining local defect resonances, the use of an image subtraction method and the reduction of equipment based nonlinearities using CNA result in greater repeatability and clearer nonlinear imaging (NIM).

Local Matrix-Cluster Interactions In La1-x SrxCoO3.

NASA Astrophysics Data System (ADS)

Giblin, Sean; Terry, Ian; Boothroyd, Andrew; Prabhakaran, Dharmalingiam; Wu, Jing; Leighton, Chris

2006-03-01

Magneto-electronic phase separation plays an integral part in many recent advances in the understanding of correlated electron systems. We have studied the magnetically phase separated material La1-x SrxCoO3 and the parent compound LaCoO3, using muon spectroscopy and magnetic susceptibility measurements. The muon as a local magnetic probe is sensitive to the magnetic field distribution in LaCoO3 in the LS state, which is a direct consequence of magnetic excitons. We believe that these excitons are interacting with the Co ions undergoing the known thermally induced spin transition. By directly comparing the results of the parent compound with La1-x SrxCoO3 we can observe the hole-rich ferromagnetic clusters interacting with the neighboring hole poor matrix for low x. This mechanism, detected here for the first time, may play an important role in the rich electrical and magnetic properties of La1-x SrxCoO3.

Effect of strong disorder on three-dimensional chiral topological insulators: Phase diagrams, maps of the bulk invariant, and existence of topological extended bulk states

NASA Astrophysics Data System (ADS)

Song, Juntao; Fine, Carolyn; Prodan, Emil

2014-11-01

The effect of strong disorder on chiral-symmetric three-dimensional lattice models is investigated via analytical and numerical methods. The phase diagrams of the models are computed using the noncommutative winding number, as functions of disorder strength and model's parameters. The localized/delocalized characteristic of the quantum states is probed with level statistics analysis. Our study reconfirms the accurate quantization of the noncommutative winding number in the presence of strong disorder, and its effectiveness as a numerical tool. Extended bulk states are detected above and below the Fermi level, which are observed to undergo the so-called "levitation and pair annihilation" process when the system is driven through a topological transition. This suggests that the bulk invariant is carried by these extended states, in stark contrast with the one-dimensional case where the extended states are completely absent and the bulk invariant is carried by the localized states.

Glasslike Membrane Protein Diffusion in a Crowded Membrane.

PubMed

Munguira, Ignacio; Casuso, Ignacio; Takahashi, Hirohide; Rico, Felix; Miyagi, Atsushi; Chami, Mohamed; Scheuring, Simon

2016-02-23

Many functions of the plasma membrane depend critically on its structure and dynamics. Observation of anomalous diffusion in vivo and in vitro using fluorescence microscopy and single particle tracking has advanced our concept of the membrane from a homogeneous fluid bilayer with freely diffusing proteins to a highly organized crowded and clustered mosaic of lipids and proteins. Unfortunately, anomalous diffusion could not be related to local molecular details given the lack of direct and unlabeled molecular observation capabilities. Here, we use high-speed atomic force microscopy and a novel analysis methodology to analyze the pore forming protein lysenin in a highly crowded environment and document coexistence of several diffusion regimes within one membrane. We show the formation of local glassy phases, where proteins are trapped in neighbor-formed cages for time scales up to 10 s, which had not been previously experimentally reported for biological membranes. Furthermore, around solid-like patches and immobile molecules a slower glass phase is detected leading to protein trapping and creating a perimeter of decreased membrane diffusion.

Overlapping communities from dense disjoint and high total degree clusters

NASA Astrophysics Data System (ADS)

Zhang, Hongli; Gao, Yang; Zhang, Yue

2018-04-01

Community plays an important role in the field of sociology, biology and especially in domains of computer science, where systems are often represented as networks. And community detection is of great importance in the domains. A community is a dense subgraph of the whole graph with more links between its members than between its members to the outside nodes, and nodes in the same community probably share common properties or play similar roles in the graph. Communities overlap when nodes in a graph belong to multiple communities. A vast variety of overlapping community detection methods have been proposed in the literature, and the local expansion method is one of the most successful techniques dealing with large networks. The paper presents a density-based seeding method, in which dense disjoint local clusters are searched and selected as seeds. The proposed method selects a seed by the total degree and density of local clusters utilizing merely local structures of the network. Furthermore, this paper proposes a novel community refining phase via minimizing the conductance of each community, through which the quality of identified communities is largely improved in linear time. Experimental results in synthetic networks show that the proposed seeding method outperforms other seeding methods in the state of the art and the proposed refining method largely enhances the quality of the identified communities. Experimental results in real graphs with ground-truth communities show that the proposed approach outperforms other state of the art overlapping community detection algorithms, in particular, it is more than two orders of magnitude faster than the existing global algorithms with higher quality, and it obtains much more accurate community structure than the current local algorithms without any priori information.

Real time flaw detection and characterization in tube through partial least squares and SVR: Application to eddy current testing

NASA Astrophysics Data System (ADS)

Ahmed, Shamim; Miorelli, Roberto; Calmon, Pierre; Anselmi, Nicola; Salucci, Marco

2018-04-01

This paper describes Learning-By-Examples (LBE) technique for performing quasi real time flaw localization and characterization within a conductive tube based on Eddy Current Testing (ECT) signals. Within the framework of LBE, the combination of full-factorial (i.e., GRID) sampling and Partial Least Squares (PLS) feature extraction (i.e., GRID-PLS) techniques are applied for generating a suitable training set in offine phase. Support Vector Regression (SVR) is utilized for model development and inversion during offine and online phases, respectively. The performance and robustness of the proposed GIRD-PLS/SVR strategy on noisy test set is evaluated and compared with standard GRID/SVR approach.

Micro-Raman scattering and dielectric investigations of phase transitions behavior in the PbHf0.7Sn0.3O3 single crystal

NASA Astrophysics Data System (ADS)

Jankowska-Sumara, Irena; Ko, Jae-Hyeon; Podgórna, Maria; Oh, Soo Han; Majchrowski, Andrzej

2017-09-01

Raman light scattering was used to detect the sequence of transitions in a PbHf1-xSnxO3 (PHS) single crystal with x = 0.30 in a temperature range of 77-873 K. Changes of Raman spectra were observed in the vicinity of structural phase transitions: between the antiferroelectric (AFE1)-antiferroelectric (AFE2)—intermediate—paraelectric phases. Light scattering and dielectric investigations were used to find out the nature and sequence of the phase transition, as well as the large dielectric permittivity values measured at the phase transition, by searching for the soft-phonon-mode behavior. The experimentally recorded spectra were analyzed in terms of the damped-harmonic oscillator model for the phonon bands. It is demonstrated that the structural phase transformations in PHS can be considered as the result of softening of many modes, not only the ferroelectric one. It was also proved that locally broken symmetry effects are present at temperatures far above the Curie temperature and are connected with the softening of two optic modes of different nature.

Acquiring 3-D information about thick objects from differential interference contrast images using texture extraction

NASA Astrophysics Data System (ADS)

Sierra, Heidy; Brooks, Dana; Dimarzio, Charles

2010-07-01

The extraction of 3-D morphological information about thick objects is explored in this work. We extract this information from 3-D differential interference contrast (DIC) images by applying a texture detection method. Texture extraction methods have been successfully used in different applications to study biological samples. A 3-D texture image is obtained by applying a local entropy-based texture extraction method. The use of this method to detect regions of blastocyst mouse embryos that are used in assisted reproduction techniques such as in vitro fertilization is presented as an example. Results demonstrate the potential of using texture detection methods to improve morphological analysis of thick samples, which is relevant to many biomedical and biological studies. Fluorescence and optical quadrature microscope phase images are used for validation.

GAWK, a novel human pituitary polypeptide: isolation, immunocytochemical localization and complete amino acid sequence.

PubMed

Benjannet, S; Leduc, R; Lazure, C; Seidah, N G; Marcinkiewicz, M; Chrétien, M

1985-01-16

During the course of reverse-phase high pressure liquid chromatography (RP-HPLC) purification of a postulated big ACTH (1) from human pituitary gland extracts, a highly purified peptide bearing no resemblance to any known polypeptide was isolated. The complete sequence of this 74 amino acid polypeptide, called GAWK, has been determined. Search on a computer data bank on the possible homology to any known protein or fragment, using a mutation data matrix, failed to reveal any homology greater than 30%. An antibody produced against a synthetic fragment allowed us to detect several immunoreactive forms. The antisera also enabled us to localize the polypeptide, by immunocytochemistry, in the anterior lobe of the pituitary gland.

Continuous variable quantum key distribution with a real local oscillator using simultaneous pilot signals.

PubMed

Kleis, Sebastian; Rueckmann, Max; Schaeffer, Christian G

2017-04-15

In this Letter, we propose a novel implementation of continuous variable quantum key distribution that operates with a real local oscillator placed at the receiver site. In addition, pulsing of the continuous wave laser sources is not required, leading to an extraordinary practical and secure setup. It is suitable for arbitrary schemes based on modulated coherent states and heterodyne detection. The shown results include transmission experiments, as well as an excess noise analysis applying a discrete 8-state phase modulation. Achievable key rates under collective attacks are estimated. The results demonstrate the high potential of the approach to achieve high secret key rates at relatively low effort and cost.

Intruder signature analysis from a phase-sensitive distributed fiber-optic perimeter sensor

NASA Astrophysics Data System (ADS)

Madsen, C. K.; Bae, T.; Snider, T.

2007-09-01

Using a phase-sensitive optical time-domain reflectometer developed at Texas A&M University, this paper reports on recent advances in intruder detection and classificatoin for long perimeters or borders. The system uses light pulses from a narrow linewidth CW laser with low frequency drift to interrogate an optical fiber. The backscattered light is detected, and real-time processing of the received signal is performed. Signatures from single and multiple humans on foot, nearby vehicle traffic on a road, construction-like vehicle activity, and animals have been obtained. Individual footsteps are clearly identified and the cadence readily observed. Time-frequency plots are used to compare the signatures. The detected signal contains information regarding the weight of the intruder as well. An adult weighing around 60kg may produce several π-radian shifts in the optical phase, which is detected by the system. While distances up to 20km have been monitored in previous remote field tests, we report measurements on a local test site with a total fiber length of 12km. A 3-mm diameter fiber cable is buried at a depth of 20-46 cm over a distance of 44m, with a 2km spool of fiber attached prior to the buried fiber and a 10km fiber spool connected in series after the buried section. Recent advances in data acquisition and signal processing allow us to avoid false alarms due to drifts in the laser center frequency and greatly improve the probability of detection. With these advancements, this technology is prime for low-cost perimeter monitoring of high-value and high-security installations such as nuclear power plants and military bases as well as national borders.

The correlation of local deformation and stress-assisted local phase transformations in MMC foams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berek, H., E-mail: harry.berek@ikgb.tu-freiberg.de; Ballaschk, U.; Aneziris, C.G.

2015-09-15

Cellular structures are of growing interest for industry, and are of particular importance for lightweight applications. In this paper, a special case of metal matrix composite foams (MMCs) is investigated. The investigated foams are composed of austenitic steel exhibiting transformation induced plasticity (TRIP) and magnesia partially stabilized zirconia (Mg-PSZ). Both components exhibit martensitic phase transformation during deformation, thus generating the potential for improved mechanical properties such as strength, ductility, and energy absorption capability. The aim of these investigations was to show that stress-assisted phase transformations within the ceramic reinforcement correspond to strong local deformation, and to determine whether they canmore » trigger martensitic phase transformations in the steel matrix. To this end, in situ interrupted compression experiments were performed in an X-ray computed tomography device (XCT). By using a recently developed registration algorithm, local deformation could be calculated and regions of interest could be defined. Corresponding cross sections were prepared and used to analyze the local phase composition by electron backscatter diffraction (EBSD). The results show a strong correlation between local deformation and phase transformation. - Graphical abstract: Display Omitted - Highlights: • In situ compressive deformation on MMC foams was performed in an XCT. • Local deformation fields and their gradient amplitudes were estimated. • Cross sections were manufactured containing defined regions of interest. • Local EBSD phase analysis was performed. • Local deformation and local phase transformation are correlated.« less

Frequency-Modulated, Continuous-Wave Laser Ranging Using Photon-Counting Detectors

NASA Technical Reports Server (NTRS)

Erkmen, Baris I.; Barber, Zeb W.; Dahl, Jason

2014-01-01

Optical ranging is a problem of estimating the round-trip flight time of a phase- or amplitude-modulated optical beam that reflects off of a target. Frequency- modulated, continuous-wave (FMCW) ranging systems obtain this estimate by performing an interferometric measurement between a local frequency- modulated laser beam and a delayed copy returning from the target. The range estimate is formed by mixing the target-return field with the local reference field on a beamsplitter and detecting the resultant beat modulation. In conventional FMCW ranging, the source modulation is linear in instantaneous frequency, the reference-arm field has many more photons than the target-return field, and the time-of-flight estimate is generated by balanced difference- detection of the beamsplitter output, followed by a frequency-domain peak search. This work focused on determining the maximum-likelihood (ML) estimation algorithm when continuous-time photoncounting detectors are used. It is founded on a rigorous statistical characterization of the (random) photoelectron emission times as a function of the incident optical field, including the deleterious effects caused by dark current and dead time. These statistics enable derivation of the Cramér-Rao lower bound (CRB) on the accuracy of FMCW ranging, and derivation of the ML estimator, whose performance approaches this bound at high photon flux. The estimation algorithm was developed, and its optimality properties were shown in simulation. Experimental data show that it performs better than the conventional estimation algorithms used. The demonstrated improvement is a factor of 1.414 over frequency-domainbased estimation. If the target interrogating photons and the local reference field photons are costed equally, the optimal allocation of photons between these two arms is to have them equally distributed. This is different than the state of the art, in which the local field is stronger than the target return. The optimal processing of the photocurrent processes at the outputs of the two detectors is to perform log-matched filtering followed by a summation and peak detection. This implies that neither difference detection, nor Fourier-domain peak detection, which are the staples of the state-of-the-art systems, is optimal when a weak local oscillator is employed.

Local ablation therapy with contrast-enhanced ultrasonography for hepatocellular carcinoma: a practical review

PubMed Central

Kim, Tae Kyoung; Khalili, Korosh; Jang, Hyun-Jung

2015-01-01

A successful program for local ablation therapy for hepatocellular carcinoma (HCC) requires extensive imaging support for diagnosis and localization of HCC, imaging guidance for the ablation procedures, and post-treatment monitoring. Contrast-enhanced ultrasonography (CEUS) has several advantages over computed tomography/magnetic resonance imaging (CT/MRI), including real-time imaging capability, sensitive detection of arterial-phase hypervascularity and washout, no renal excretion, no ionizing radiation, repeatability, excellent patient compliance, and relatively low cost. CEUS is useful for image guidance for isoechoic lesions. While contrast-enhanced CT/MRI is the standard method for the diagnosis of HCC and post-ablation monitoring, CEUS is useful when CT/MRI findings are indeterminate or CT/MRI is contraindicated. This article provides a practical review of the role of CEUS in imaging algorithms for pre- and post-ablation therapy for HCC. PMID:26169081

Advances in pancreatic cancer research: moving towards early detection.

PubMed

He, Xiang-Yi; Yuan, Yao-Zong

2014-08-28

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer. Substantial progress has been made in the understanding of the biology of pancreatic cancer, and advances in patient management have been significant. However, most patients (nearly 80%) who present with locally advanced or metastatic disease have an extremely poor prognosis. Survival is better for those with malignant disease localized to the pancreas, because surgical resection at present offers the only chance of cure. Therefore, the early detection of pancreatic cancer may benefit patients with PDAC. However, its low rate of incidence and the limitations of current screening strategies make early detection difficult. Recent advances in the understanding of the pathogenesis of PDAC suggest that it is possible to detect PDAC in early stages and even identify precursor lesions. The presence of new-onset diabetes mellitus in the early phase of pancreatic cancer may provide clues for its early diagnosis. Advances in the identification of novel circulating biomarkers including serological signatures, autoantibodies, epigenetic markers, circulating tumor cells and microRNAs suggest that they can be used as potential tools for the screening of precursors and early stage PDAC in the future. However, proper screening strategies based on effective screening methodologies need to be tested for clinical application.

Complex local Moho topography in the Western Carpathians: Indication of the ALCAPA and the European Plate contact

NASA Astrophysics Data System (ADS)

Hrubcová, Pavla; Środa, Piotr

2015-04-01

Seismic data from deep refraction and wide-angle reflection profiles intersecting the Western Carpathians show distinct upper-mantle Pn phases with anomalous apparent velocities identified in the first and later arrivals. Their systematic analysis indicates that such phases are present in numerous seismic sections both for in-line and off-line shots. They are observed in data from profiles intersecting the Carpathians in the west at the contact with the Bohemian Massif; similar feature was also found in data at the northern edge of the Carpathians at the contact with the North European Platform. Modelling of these anomalous Pn phases shows that they originate due to local structural anomalies of the Moho discontinuity detected in several places along the Western Carpathian arc. Such anomalies are located in close lateral proximity of the Pieniny Klippen Belt representing the contact between the stable European Plate in the north and the ALCAPA (Alpine-Carpathian-Pannonian) microplate in the south. Thus, the complex local Moho topography modelled from the Pn phases suggests tectonic relation to the formation of the Carpathian orogen. The result is supported by correlation with the large-scale Carpathian conductivity anomaly modelled in the Carpathians at a mid-crustal level. Relative lateral position of these two structures together with the Pieniny Klippen Belt at the surface delineates a zone affected by deformations at various depths along the whole Western Carpathian arc. Tectonically, such course of the anomalous zone suggests that its origin is connected with the lithospheric deformations occurring near the contact of the European Plate and the ALCAPA microplate during the Carpathian orogeny, i.e., it is related to the collisional/transpressional processes during and after the Tertiary. Reference: Hrubcová, P., and Środa, P., Complex local Moho topography in the Western Carpathians: Indication of the ALCAPA and the European Plate contact. Tectonophysics, 2014, doi: 10.1016/j.tecto.2014.10.013.

Does Management Matter?: Using MISR to Assess the Effects of Charcoal Production and Management on Woodland Regeneration

NASA Astrophysics Data System (ADS)

Wurster, K.

2008-12-01

In much of Sub-Saharan Africa, more than 75 percent of a rapidly growing urban population depends on charcoal as their primary source of energy for cooking. The high demand for charcoal has led many to believe that charcoal harvesting catalyzes widespread deforestation. The Senegalese government and international donors have initiated projects within protected areas to combat deforestation and created land management plans to sustainably harvest charcoal. To date, the effects of forest management techniques on forest sustainability are still in question. This research uses a multiphase approach integrating satellite analysis with field surveys to assess the effect of varying forest management strategies on forest regeneration and sustainability after charcoal harvesting. Phase I involved testing the Multiangle Imaging SpectroRadiometer (MISR) satellites capability in detecting structural changes in vegetative cover caused by charcoal harvesting and production. Analysis of the MISR derived k(red) parameter showed MISR can consistently differentiate between forest cover types and successfully differentiates between sites at pre- and post-charcoal harvest stages. Phase II conducted forestry and social surveys comparing and contrasting local effects of land management, land use, and charcoal production on forest regeneration. Phase III uses the local surveys to validate and train the regional remote sensing data to assess the effectiveness of land management in promoting forest regeneration and sustainability after charcoal harvesting. Combining detailed local knowledge with the regional capabilities of MISR provide valuable insight into the factors that control woodland regeneration and sustainability. Preliminary results from phases II and III indicate that both field and remotely sensed variations in forest cover, tree regeneration, and land use change does not vary when compared against land management type. Final results will provide managers with additional information to create more effective land management strategies that can be implemented across sub- Saharan Africa, ensuring the long-term sustainability of woodland ecosystems and local livelihoods.

EGFR T790M mutation testing within the osimertinib AURA Phase I study.

PubMed

Dearden, Simon; Brown, Helen; Jenkins, Suzanne; Thress, Kenneth S; Cantarini, Mireille; Cole, Rebecca; Ranson, Malcolm; Jänne, Pasi A

2017-07-01

Reliable epidermal growth factor receptor (EGFR) mutation testing techniques are required to identify eligible patients with EGFR mutation/T790M positive advanced non-small cell lung cancer (NSCLC), for treatment with osimertinib (AZD9291), an oral, potent, irreversible EGFR tyrosine kinase inhibitor (TKI) selective for EGFR-TKI-sensitizing and T790M resistance mutations over wild-type EGFR. There is no current consensus regarding the best method to detect EGFR T790M mutations. The aim of this study was to describe the concordance between local testing, which used a variety of methods, and central testing, using the cobas ® EGFR Mutation Test, for EGFR-sensitizing mutations and the T790M resistance mutation. Tumor samples were obtained from all patients screened for inclusion onto the osimertinib Phase I expansion component of the AURA Phase I/II study (NCT01802632). Samples underwent central laboratory testing for EGFR-sensitizing mutations and T790M resistance mutation using the cobas ® EGFR Mutation Test. Results were compared with local laboratory test results, based on other testing methodologies including Sanger sequencing, therascreen ® , PNAClamp™, and Sequenom MassARRAY ® . Central laboratory testing was successful in 99% of samples passing histopathology review and testing success rates were comparable across the three central laboratories. Concordance between central and local testing for common sensitizing mutations was high (>98%) and concordance for the T790M mutation was also high (>90%). Tumor heterogeneity, along with other technical factors may have influenced this result. Within the osimertinib AURA Phase I study, EGFR mutation testing across three centralized laboratories using the cobas ® EGFR Mutation Test was feasible and successful, with strong concordance between local and central laboratory results, including for T790M. The cobas ® EGFR Mutation Test has subsequently been approved as the companion diagnostic test for osimertinib in the USA and Japan. Copyright © 2017 Elsevier B.V. All rights reserved.

Recent Progress on GRBs with Swift

NASA Technical Reports Server (NTRS)

Gehrels, N.; Cannizzo, J. K.

2010-01-01

We are in an exciting period of discovery for gamma-ray bursts. The Swift observatory is detecting 100 bursts per year, providing arcsecond localizations and sensitive observations of the prompt and afterglow emission. In addition, rapid-response telescopes on the ground have new capabilities to study optical emission during the prompt phase and spectral signatures of the host galaxies. The combined data set is enabling great advances in our understanding of GRBs including afterglow physics, short burst origin, and supernova physics.

Link Performance Analysis of a Ship-to-Ship Laser Communication System

DTIC Science & Technology

2012-03-01

the optical output by a modulating signal. Direct detection requires only the intensity, and not the phase information, of the input signal to...links have a higher signal-to-noise ratio ( ) as compared to RF link. However, at approximately 108 km, the SNR for the optical links is much... optical signal received is mixed with a light signal generated from a local oscillator laser (LO-laser). The combined signals are then impinged onto the

A combined phase contrast imaging-interferometer system for the detection of multiscale density fluctuations on DIII-D

NASA Astrophysics Data System (ADS)

Davis, E. M.; Rost, J. C.; Porkolab, M.; Marinoni, A.; van Zeeland, M. A.

2016-10-01

A heterodyne interferometer channel has been added to the DIII-D phase contrast imaging (PCI) system. Both measurements share a single 10.6 μm probe beam. Whereas the PCI excels at detecting medium- to high- k fluctuations (1.5 cm-1 <= k <= 20 cm-1), the interferometer extends the system sensitivity to low- k fluctuations (k <= 5 cm-1), allowing simultaneous measurement of electron- and ion-scale instabilities with sub-microsecond resolution. Further, correlating measurements from the interferometer channel with those from DIII-D's pre-existing, toroidally separated interferometer (Δ∅ = 45°) allows identification of low- n modes. This new capability has been corroborated against magnetic measurements and may allow novel investigations of core - localized MHD that is otherwise inaccessible via external magnetic measurements, with potential applications to fast particle transport and disruptions. Work supported by USDOE under DE-FG02-94ER54235, DE-FC02-04ER54698, and DE-FC02-99ER54512.

Gamma-ray bursts and their use as cosmic probes

PubMed Central

2017-01-01

Since the launch of the highly successful and ongoing Swift mission, the field of gamma-ray bursts (GRBs) has undergone a revolution. The arcsecond GRB localizations available within just a few minutes of the GRB alert has signified the continual sampling of the GRB evolution through the prompt to afterglow phases revealing unexpected flaring and plateau phases, the first detection of a kilonova coincident with a short GRB, and the identification of samples of low-luminosity, ultra-long and highly dust-extinguished GRBs. The increased numbers of GRB afterglows, GRB-supernova detections, redshifts and host galaxy associations has greatly improved our understanding of what produces and powers these immense, cosmological explosions. Nevertheless, more high-quality data often also reveal greater complexity. In this review, I summarize some of the milestones made in GRB research during the Swift era, and how previous widely accepted theoretical models have had to adapt to accommodate the new wealth of observational data. PMID:28791158

Control of complex components with Smart Flexible Phased Arrays.

PubMed

Casula, O; Poidevin, C; Cattiaux, G; Dumas, Ph

2006-12-22

The inspection is mainly performed in contact with ultrasonic wedge transducers; However, the shape cannot fit the changing geometries of components (butt weld, nozzle, elbow). The variable thickness of the coupling layer, between the wedge and the local surface, leads to beam distortions and losses of sensitivity. Previous studies have shown that these two phenomena contribute to reduce the inspection performances leading to shadow area, split beam.... Flexible phased arrays have been developed to fit the complex profile and improve such controls. The radiating surface is composed with independent piezoelectric elements mechanically assembled and a profilometer, embedded in the transducer, measures the local distortion. The computed shape is used by an algorithm to compute in real-time the adapted delay laws compensating the distortions of 2D or 3D profiles. Those delay laws are transferred to the real-time UT acquisition system, which applies them to the piezoelectric elements. This self-adaptive process preserves, during the scanning, the features of the focused beam (orientation and focal depth) in the specimen. To validate the concept of the Smart Flexible Phased Array Transducer, prototypes have been integrated to detect flaws machined in mock-ups with realistic irregular 2D and 3D shapes. Inspections have been carried out on samples showing the enhancement performances of the "Smart Flexible Phased Array" and validating the mechanical and acoustical behaviors of these probes.

Neural correlates of binaural masking level difference in the inferior colliculus of the barn owl (Tyto alba).

PubMed

Asadollahi, Ali; Endler, Frank; Nelken, Israel; Wagner, Hermann

2010-08-01

Humans and animals are able to detect signals in noisy environments. Detection improves when the noise and the signal have different interaural phase relationships. The resulting improvement in detection threshold is called the binaural masking level difference. We investigated neural mechanisms underlying the release from masking in the inferior colliculus of barn owls in low-frequency and high-frequency neurons. A tone (signal) was presented either with the same interaural time difference as the noise (masker) or at a 180 degrees phase shift as compared with the interaural time difference of the noise. The changes in firing rates induced by the addition of a signal of increasing level while masker level was kept constant was well predicted by the relative responses to the masker and signal alone. In many cases, the response at the highest signal levels was dominated by the response to the signal alone, in spite of a significant response to the masker at low signal levels, suggesting the presence of occlusion. Detection thresholds and binaural masking level differences were widely distributed. The amount of release from masking increased with increasing masker level. Narrowly tuned neurons in the central nucleus of the inferior colliculus had detection thresholds that were lower than or similar to those of broadly tuned neurons in the external nucleus of the inferior colliculus. Broadly tuned neurons exhibited higher masking level differences than narrowband neurons. These data suggest that detection has different spectral requirements from localization.

Methylparaben concentration in commercial Brazilian local anesthetics solutions

PubMed Central

da SILVA, Gustavo Henrique Rodriguez; BOTTOLI, Carla Beatriz Grespan; GROPPO, Francisco Carlos; VOLPATO, Maria Cristina; RANALI, José; RAMACCIATO, Juliana Cama; MOTTA, Rogério Heládio Lopes

2012-01-01

Objective To detect the presence and concentration of methylparaben in cartridges of commercial Brazilian local anesthetics. Material and methods Twelve commercial brands (4 in glass and 8 in plastic cartridges) of local anesthetic solutions for use in dentistry were purchased from the Brazilian market and analyzed. Different lots of the commercial brands were obtained in different Brazilian cities (Piracicaba, Campinas and São Paulo). Separation was performed using high performance liquid chromatography (HPLC) with UV-Vis detector. The mobile phase used was acetonitrile:water (75:25 - v/v), pH 4.5, adjusted with acetic acid at a flow rate of 1.0 ml.min-1. Results When detected in the solutions, the methylparaben concentration ranged from 0.01% (m/v) to 0.16% (m/v). One glass and all plastic cartridges presented methylparaben. Conclusion 1. Methylparaben concentration varied among solutions from different manufacturers, and it was not indicated in the drug package inserts; 2. Since the presence of methylparaben in dental anesthetics is not regulated by the Brazilian National Health Surveillance Agency (ANVISA) and this substance could cause allergic reactions, it is important to alert dentists about its possible presence. PMID:23032206

Recent progress in distributed fiber optic sensors.

PubMed

Bao, Xiaoyi; Chen, Liang

2012-01-01

Rayleigh, Brillouin and Raman scatterings in fibers result from the interaction of photons with local material characteristic features like density, temperature and strain. For example an acoustic/mechanical wave generates a dynamic density variation; such a variation may be affected by local temperature, strain, vibration and birefringence. By detecting changes in the amplitude, frequency and phase of light scattered along a fiber, one can realize a distributed fiber sensor for measuring localized temperature, strain, vibration and birefringence over lengths ranging from meters to one hundred kilometers. Such a measurement can be made in the time domain or frequency domain to resolve location information. With coherent detection of the scattered light one can observe changes in birefringence and beat length for fibers and devices. The progress on state of the art technology for sensing performance, in terms of spatial resolution and limitations on sensing length is reviewed. These distributed sensors can be used for disaster prevention in the civil structural monitoring of pipelines, bridges, dams and railroads. A sensor with centimeter spatial resolution and high precision measurement of temperature, strain, vibration and birefringence can find applications in aerospace smart structures, material processing, and the characterization of optical materials and devices.

Recent Progress in Distributed Fiber Optic Sensors

PubMed Central

Bao, Xiaoyi; Chen, Liang

2012-01-01

Rayleigh, Brillouin and Raman scatterings in fibers result from the interaction of photons with local material characteristic features like density, temperature and strain. For example an acoustic/mechanical wave generates a dynamic density variation; such a variation may be affected by local temperature, strain, vibration and birefringence. By detecting changes in the amplitude, frequency and phase of light scattered along a fiber, one can realize a distributed fiber sensor for measuring localized temperature, strain, vibration and birefringence over lengths ranging from meters to one hundred kilometers. Such a measurement can be made in the time domain or frequency domain to resolve location information. With coherent detection of the scattered light one can observe changes in birefringence and beat length for fibers and devices. The progress on state of the art technology for sensing performance, in terms of spatial resolution and limitations on sensing length is reviewed. These distributed sensors can be used for disaster prevention in the civil structural monitoring of pipelines, bridges, dams and railroads. A sensor with centimeter spatial resolution and high precision measurement of temperature, strain, vibration and birefringence can find applications in aerospace smart structures, material processing, and the characterization of optical materials and devices. PMID:23012508

Probing the symmetry of the potential of localized surface plasmon resonances with phase-shaped electron beams

PubMed Central

Guzzinati, Giulio; Béché, Armand; Lourenço-Martins, Hugo; Martin, Jérôme; Kociak, Mathieu; Verbeeck, Jo

2017-01-01

Plasmonics, the science and technology of the interaction of light with metallic objects, is fundamentally changing the way we can detect, generate and manipulate light. Although the field is progressing swiftly, thanks to the availability of nanoscale manufacturing and analysis methods, fundamental properties such as the plasmonic excitations' symmetries cannot be accessed directly, leading to a partial, sometimes incorrect, understanding of their properties. Here we overcome this limitation by deliberately shaping the wave function of an electron beam to match a plasmonic excitations' symmetry in a modified transmission electron microscope. We show experimentally and theoretically that this offers selective detection of specific plasmon modes within metallic nanoparticles, while excluding modes with other symmetries. This method resembles the widespread use of polarized light for the selective excitation of plasmon modes with the advantage of locally probing the response of individual plasmonic objects and a far wider range of symmetry selection criteria. PMID:28401942

Interferometric 2D Sum Frequency Generation Spectroscopy Reveals Structural Heterogeneity of Catalytic Monolayers on Transparent Materials.

PubMed

Vanselous, Heather; Stingel, Ashley M; Petersen, Poul B

2017-02-16

Molecular monolayers exhibit structural and dynamical properties that are different from their bulk counterparts due to their interaction with the substrate. Extracting these distinct properties is crucial for a better understanding of processes such as heterogeneous catalysis and interfacial charge transfer. Ultrafast nonlinear spectroscopic techniques such as 2D infrared (2D IR) spectroscopy are powerful tools for understanding molecular dynamics in complex bulk systems. Here, we build on technical advancements in 2D IR and heterodyne-detected sum frequency generation (SFG) spectroscopy to study a CO 2 reduction catalyst on nanostructured TiO 2 with interferometric 2D SFG spectroscopy. Our method combines phase-stable heterodyne detection employing an external local oscillator with a broad-band pump pulse pair to provide the first high spectral and temporal resolution 2D SFG spectra of a transparent material. We determine the overall molecular orientation of the catalyst and find that there is a static structural heterogeneity reflective of different local environments at the surface.

[Multiparametric 3T MRI in the routine staging of prostate cancer].

PubMed

Largeron, J P; Galonnier, F; Védrine, N; Alfidja, A; Boyer, L; Pereira, B; Boiteux, J P; Kemeny, J L; Guy, L

2014-03-01

To analyse the detection ability of a multiparametric 3T MRI with phased-array coil in comparison with the pathological data provided by the prostatectomy specimens. Prospective study of 30 months, including 74 patients for whom a diagnosis of prostate cancer had been made on randomized prostate biopsies, and all eligible to a radical prostatectomy. They all underwent multiparametric 3T MRI with pelvic phased-array coil including T2-weighted imaging (T2W), dynamic contrast-enhanced (DCE) and diffusion-weighted imaging (DWI) with an ADC mapping. Each gland was divided in octants. Three specific criteria have been sought (detection ability, capsular contact [CC] and extracapsular extension [ECE]), in comparison with the pathological data provided by the prostatectomy specimens. Five hundred and ninety-two octants were considered with 124 significant tumors (volume ≥ 0.1cm(3)). The general ability of tumor detection had a sensitivity, specificity, PPV and NPV respectively to 72.3%, 87.4%, 83.2% and 78.5%. The estimate of the CC and ECE had a high negative predictive power with specificities and VPN respectively to 96.4% and 95.4% for CC, and 97.5 and 97.7% for ECE. Multiparametric 3T MRI with pelvic phased-array coil appeared to be a reliable imaging technique in clinical and routine practice for the detection of localized prostate cancer. Estimation of the CC and millimeter ECE remains to be clarified, even if the negative predictive power for these parameters seems encouraging. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Using lod scores to detect sex differences in male-female recombination fractions.

PubMed

Feenstra, B; Greenberg, D A; Hodge, S E

2004-01-01

Human recombination fraction (RF) can differ between males and females, but investigators do not always know which disease genes are located in genomic areas of large RF sex differences. Knowledge of RF sex differences contributes to our understanding of basic biology and can increase the power of a linkage study, improve gene localization, and provide clues to possible imprinting. One way to detect these differences is to use lod scores. In this study we focused on detecting RF sex differences and answered the following questions, in both phase-known and phase-unknown matings: (1) How large a sample size is needed to detect a RF sex difference? (2) What are "optimal" proportions of paternally vs. maternally informative matings? (3) Does ascertaining nonoptimal proportions of paternally or maternally informative matings lead to ascertainment bias? Our results were as follows: (1) We calculated expected lod scores (ELODs) under two different conditions: "unconstrained," allowing sex-specific RF parameters (theta(female), theta(male)); and "constrained," requiring theta(female) = theta(male). We then examined the DeltaELOD (identical with difference between maximized constrained and unconstrained ELODs) and calculated minimum sample sizes required to achieve statistically significant DeltaELODs. For large RF sex differences, samples as small as 10 to 20 fully informative matings can achieve statistical significance. We give general sample size guidelines for detecting RF differences in informative phase-known and phase-unknown matings. (2) We defined p as the proportion of paternally informative matings in the dataset; and the optimal proportion p(circ) as that value of p that maximizes DeltaELOD. We determined that, surprisingly, p(circ) does not necessarily equal (1/2), although it does fall between approximately 0.4 and 0.6 in most situations. (3) We showed that if p in a sample deviates from its optimal value, no bias is introduced (asymptotically) to the maximum likelihood estimates of theta(female) and theta(male), even though ELOD is reduced (see point 2). This fact is important because often investigators cannot control the proportions of paternally and maternally informative families. In conclusion, it is possible to reliably detect sex differences in recombination fraction. Copyright 2004 S. Karger AG, Basel

Invariance of the bit error rate in the ancilla-assisted homodyne detection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoshida, Yuhsuke; Takeoka, Masahiro; Sasaki, Masahide

2010-11-15

We investigate the minimum achievable bit error rate of the discrimination of binary coherent states with the help of arbitrary ancillary states. We adopt homodyne measurement with a common phase of the local oscillator and classical feedforward control. After one ancillary state is measured, its outcome is referred to the preparation of the next ancillary state and the tuning of the next mixing with the signal. It is shown that the minimum bit error rate of the system is invariant under the following operations: feedforward control, deformations, and introduction of any ancillary state. We also discuss the possible generalization ofmore » the homodyne detection scheme.« less

Enhanced backscatter of optical beams reflected in atmospheric turbulence

NASA Astrophysics Data System (ADS)

Nelson, W.; Palastro, J. P.; Wu, C.; Davis, C. C.

2014-10-01

Optical beams propagating through the atmosphere acquire phase distortions from turbulent fluctuations in the refractive index. While these distortions are usually deleterious to propagation, beams reflected in a turbulent medium can undergo a local recovery of spatial coherence and intensity enhancement referred to as enhanced backscatter (EBS). Using simulations, we investigate the EBS of optical beams reflected from mirrors, corner cubes, and rough surfaces, and identify the regimes in which EBS is most distinctly observed. Standard EBS detection requires averaging the reflected intensity over many passes through uncorrelated turbulence. Here we present an algorithm called the "tilt-shift method" which allows detection of EBS in static turbulence, improving its suitability for potential applications.

Detection of Subtle Hydromechanical Medium Changes Caused By a Small-Magnitude Earthquake Swarm in NE Brazil

NASA Astrophysics Data System (ADS)

D'Hour, V.; Schimmel, M.; Do Nascimento, A. F.; Ferreira, J. M.; Lima Neto, H. C.

2016-04-01

Ambient noise correlation analyses are largely used in seismology to map heterogeneities and to monitor the temporal evolution of seismic velocity changes associated mostly with stress field variations and/or fluid movements. Here we analyse a small earthquake swarm related to a main mR 3.7 intraplate earthquake in North-East of Brazil to study the corresponding post-seismic effects on the medium. So far, post-seismic effects have been observed mainly for large magnitude events. In our study, we show that we were able to detect localized structural changes even for a small earthquake swarm in an intraplate setting. Different correlation strategies are presented and their performances are also shown. We compare the classical auto-correlation with and without pre-processing, including 1-bit normalization and spectral whitening, and the phase auto-correlation. The worst results were obtained for the pre-processed data due to the loss of waveform details. The best results were achieved with the phase cross-correlation which is amplitude unbiased and sensitive to small amplitude changes as long as there exist waveform coherence superior to other unrelated signals and noise. The analysis of 6 months of data using phase auto-correlation and cross-correlation resulted in the observation of a progressive medium change after the major recorded event. The progressive medium change is likely related to the swarm activity through opening new path ways for pore fluid diffusion. We further observed for the auto-correlations a lag time frequency-dependent change which likely indicates that the medium change is localized in depth. As expected, the main change is observed along the fault.

An Overview of Orbital Detections of Hydrated Silica and Silica-Rich Rocks on Mars

NASA Astrophysics Data System (ADS)

Sun, V. Z.; Milliken, R.

2016-12-01

Early predictions of high-silica phases on Mars have been confirmed by numerous orbital observations throughout the past 15 years and supported by recent rover and meteorite investigations. Orbital spectroscopy at visible-near-IR (CRISM/OMEGA) and thermal IR (TES/THEMIS) wavelengths has established the presence of aqueously formed hydrated silica across the planet as well as regional silica-rich rocks of igneous origin. TES data provided the first indications of widespread silica enrichment in the northern lowlands, which were debated to represent either andesite or altered basalt on the basis of spectral and geologic arguments. Since then, more localized occurrences of primary silicic lithologies have suggested that igneous processes on Mars may have been more diverse and complex than previously recognized. CRISM and OMEGA data also reveal numerous occurrences of hydrated silica on the Martian surface, likely reflecting primary chemical precipitates or secondary processes such as aqueous alteration or diagenesis. These detections have been associated with fluvial landforms, volcanic settings, uplifted central peak rocks, and mobile sediments, suggesting a variety of formation mechanisms. These silica phases and their colocation with other alteration products such as clays and sulfates reveal aqueous environments that may have been acidic, alkaline, or alternatingly both through space and time. Although there is an apparent prevalence of geochemically immature silica (e.g., glass or opal-A) indicating limited aqueous alteration, several instances of more mature silica (e.g., opal-CT or quartz) point to locales that may have experienced periods of prolonged water-rock interaction. This presentation will give an overview of the distribution and variety of these high-silica phases as seen from orbital datasets and discuss their implications for the magmatic and aqueous history of Mars.

Bat detective-Deep learning tools for bat acoustic signal detection.

PubMed

Mac Aodha, Oisin; Gibb, Rory; Barlow, Kate E; Browning, Ella; Firman, Michael; Freeman, Robin; Harder, Briana; Kinsey, Libby; Mead, Gary R; Newson, Stuart E; Pandourski, Ivan; Parsons, Stuart; Russ, Jon; Szodoray-Paradi, Abigel; Szodoray-Paradi, Farkas; Tilova, Elena; Girolami, Mark; Brostow, Gabriel; Jones, Kate E

2018-03-01

Passive acoustic sensing has emerged as a powerful tool for quantifying anthropogenic impacts on biodiversity, especially for echolocating bat species. To better assess bat population trends there is a critical need for accurate, reliable, and open source tools that allow the detection and classification of bat calls in large collections of audio recordings. The majority of existing tools are commercial or have focused on the species classification task, neglecting the important problem of first localizing echolocation calls in audio which is particularly problematic in noisy recordings. We developed a convolutional neural network based open-source pipeline for detecting ultrasonic, full-spectrum, search-phase calls produced by echolocating bats. Our deep learning algorithms were trained on full-spectrum ultrasonic audio collected along road-transects across Europe and labelled by citizen scientists from www.batdetective.org. When compared to other existing algorithms and commercial systems, we show significantly higher detection performance of search-phase echolocation calls with our test sets. As an example application, we ran our detection pipeline on bat monitoring data collected over five years from Jersey (UK), and compared results to a widely-used commercial system. Our detection pipeline can be used for the automatic detection and monitoring of bat populations, and further facilitates their use as indicator species on a large scale. Our proposed pipeline makes only a small number of bat specific design decisions, and with appropriate training data it could be applied to detecting other species in audio. A crucial novelty of our work is showing that with careful, non-trivial, design and implementation considerations, state-of-the-art deep learning methods can be used for accurate and efficient monitoring in audio.

Gamma knife treatment for refractory epilepsy in seizure focus localized by positron emission tomography/CT★

PubMed Central

Bai, Xia; Wang, Xuemei; Wang, Hongwei; Zhao, Shigang; Han, Xiaodong; Hao, Linjun; Wang, Xiangcheng

2012-01-01

A total of 80 patients with refractory epilepsy were recruited from the Inner Mongolia Medical College Affiliated Hospital. The foci of 60% of the patients could be positioned using a combined positron emission tomography/CT imaging modality. Hyper- and hypometabolism foci were examined as part of this study. Patients who had abnormal metabolism in positron emission tomography/CT imaging were divided into intermittent-phase group and the seizure-phase group. The intermittent-phase group was further divided into a single-focus group and a multiple-foci group according to the number of seizure foci detected by imaging. Following gamma knife treatment, seizure frequency was significantly lower in the intermittent-phase group and the seizure-phase group. Wieser’s classification reached Grade I or II in nearly 40% of patients. Seizure frequency was significantly lower following treatment, but Wieser’s classification score was significantly higher in the seizure-phase group compared with the intermittent-phase group. Seizure frequency was significantly lower following treatment in the single-focus group, but Wieser’s classification score was significantly higher in the single-focus group as compared with the multiple-foci group. PMID:25317147

Steroid profiling reveals widespread local regulation of glucocorticoid levels during mouse development.

PubMed

Taves, Matthew D; Plumb, Adam W; Sandkam, Benjamin A; Ma, Chunqi; Van Der Gugten, Jessica Grace; Holmes, Daniel T; Close, David A; Abraham, Ninan; Soma, Kiran K

2015-02-01

Glucocorticoids (GCs) are produced by the adrenal glands and circulate in the blood to coordinate organismal physiology. In addition, different tissues may independently regulate their local GC levels via local GC synthesis. Here, we find that in the mouse, endogenous GCs show tissue-specific developmental patterns, rather than mirroring GCs in the blood. Using solid-phase extraction, HPLC, and specific immunoassays, we quantified endogenous steroids and found that in tissues of female and male mice, (1) local GC levels can be much higher than systemic GC levels, (2) local GCs follow age-related patterns different from those of systemic GCs, and (3) local GCs have identities different from those of systemic GCs. For example, whereas corticosterone is the predominant circulating adrenal GC in mice, high concentrations of cortisol were measured in neonatal thymus, bone marrow, and heart. The presence of cortisol was confirmed with liquid chromatography-tandem mass spectrometry. In addition, gene expression of steroidogenic enzymes was detected across multiple tissues, consistent with local GC production. Our results demonstrate that local GCs can differ from GCs in circulating blood. This finding suggests that steroids are widely used as local (paracrine or autocrine) signals, in addition to their classic role as systemic (endocrine) signals. Local GC regulation may even be the norm, rather than the exception, especially during development.

Exploring Localization in Nuclear Spin Chains

NASA Astrophysics Data System (ADS)

Wei, Ken Xuan; Ramanathan, Chandrasekhar; Cappellaro, Paola

2018-02-01

Characterizing out-of-equilibrium many-body dynamics is a complex but crucial task for quantum applications and understanding fundamental phenomena. A central question is the role of localization in quenching thermalization in many-body systems and whether such localization survives in the presence of interactions. Probing this question in real systems necessitates the development of an experimentally measurable metric that can distinguish between different types of localization. While it is known that the localized phase of interacting systems [many-body localization (MBL)] exhibits a long-time logarithmic growth in entanglement entropy that distinguishes it from the noninteracting case of Anderson localization (AL), entanglement entropy is difficult to measure experimentally. Here, we present a novel correlation metric, capable of distinguishing MBL from AL in high-temperature spin systems. We demonstrate the use of this metric to detect localization in a natural solid-state spin system using nuclear magnetic resonance (NMR). We engineer the natural Hamiltonian to controllably introduce disorder and interactions, and observe the emergence of localization. In particular, while our correlation metric saturates for AL, it slowly keeps increasing for MBL, demonstrating analogous features to entanglement entropy, as we show in simulations. Our results show that our NMR techniques, akin to measuring out-of-time correlations, are well suited for studying localization in spin systems.

Pollutant monitoring of aircraft exhaust with multispectral imaging

NASA Astrophysics Data System (ADS)

Berkson, Emily E.; Messinger, David W.

2016-10-01

Communities surrounding local airports are becoming increasingly concerned about the aircraft pollutants emitted during the landing-takeoff (LTO) cycle, and their potential for negative health effects. Chicago, Los Angeles, Boston and London have all recently been featured in the news regarding concerns over the amount of airport pollution being emitted on a daily basis, and several studies have been published on the increased risks of cancer for those living near airports. There are currently no inexpensive, portable, and unobtrusive sensors that can monitor the spatial and temporal nature of jet engine exhaust plumes. In this work we seek to design a multispectral imaging system that is capable of tracking exhaust plumes during the engine idle phase, with a specific focus on unburned hydrocarbon (UHC) emissions. UHCs are especially potent to local air quality, and their strong absorption features allow them to act as a spatial and temporal plume tracer. Using a Gaussian plume to radiometrically model jet engine exhaust, we have begun designing an inexpensive, portable, and unobtrusive imaging system to monitor the relative amount of pollutants emitted by aircraft in the idle phase. The LWIR system will use two broadband filters to detect emitted UHCs. This paper presents the spatial and temporal radiometric models of the exhaust plume from a typical jet engine used on 737s. We also select filters for plume tracking, and propose an imaging system layout for optimal detectibility. In terms of feasibility, a multispectral imaging system will be two orders of magnitude cheaper than current unobtrusive methods (PTR-MS) used to monitor jet engine emissions. Large-scale impacts of this work will include increased capabilities to monitor local airport pollution, and the potential for better-informed decision-making regarding future developments to airports.

Quantification and visualization of relative local ventilation on dynamic chest radiographs

NASA Astrophysics Data System (ADS)

Tanaka, Rie; Sanada, Shigeru; Okazaki, Nobuo; Kobayashi, Takeshi; Nakayama, Kazuya; Matsui, Takeshi; Hayashi, Norio; Matsui, Osamu

2006-03-01

Recently-developed dynamic flat-panel detector (FPD) with a large field of view is possible to obtain breathing chest radiographs, which provide respiratory kinetics information. This study was performed to investigate the ability of dynamic chest radiography using FPD to quantify relative ventilation according to respiratory physiology. We also reported the results of primary clinical study and described the possibility of clinical use of our method. Dynamic chest radiographs of 12 subjects involving abnormal subjects during respiration were obtained using a modified FPD system (30 frames in 10 seconds). Imaging was performed in three different positions (standing, and right and left decubitus positions) to change the distribution of local ventilation by changing the lung's own gravity in each area. The distance from the lung apex to the diaphragm (abbr. DLD) was measured by the edge detection technique for use as an index of respiratory phase. We measured pixel values in each lung area and calculated correlation coefficients with DLD. Differences in the pixel values between the maximum inspiratory and expiratory frame were calculated, and the trend of distribution was evaluated by two-way analysis of variance. Pixel value in each lung area was strongly associated with respiratory phase and its time variation and distribution were consistent with known properties in respiratory physiology. Dynamic chest radiography using FPD combined with our computerized methods was capable of quantifying relative amount of ventilation during respiration, and of detecting regional differences in ventilation. In the subjects with emphysema, areas with decreased respiratory changes in pixel value are consisted with the areas with air trapping. This method is expected to be a useful novel diagnostic imaging method for supporting diagnosis and follow-up of pulmonary disease, which presents with abnormalities in local ventilation.

Testing continuous earthquake detection and location in Alentejo (South Portugal) by waveform coherency analysis

NASA Astrophysics Data System (ADS)

Matos, Catarina; Grigoli, Francesco; Cesca, Simone; Custódio, Susana

2015-04-01

In the last decade a permanent seismic network of 30 broadband stations, complemented by dense temporary deployments, covered Portugal. This extraordinary network coverage enables now the computation of a high-resolution image of the seismicity of Portugal, which in turn will shed light on the seismotectonics of Portugal. The large data volumes available cannot be analyzed by traditional time-consuming manual location procedures. In this presentation we show first results on the automatic detection and location of earthquakes occurred in a selected region in the south of Portugal Our main goal is to implement an automatic earthquake detection and location routine in order to have a tool to quickly process large data sets, while at the same time detecting low magnitude earthquakes (i.e., lowering the detection threshold). We present a modified version of the automatic seismic event location by waveform coherency analysis developed by Grigoli et al. (2013, 2014), designed to perform earthquake detections and locations in continuous data. The event detection is performed by continuously computing the short-term-average/long-term-average of two different characteristic functions (CFs). For the P phases we used a CF based on the vertical energy trace, while for S phases we used a CF based on the maximum eigenvalue of the instantaneous covariance matrix (Vidale 1991). Seismic event detection and location is obtained by performing waveform coherence analysis scanning different hypocentral coordinates. We apply this technique to earthquakes in the Alentejo region (South Portugal), taking advantage from a small aperture seismic network installed in the south of Portugal for two years (2010 - 2011) during the DOCTAR experiment. In addition to the good network coverage, the Alentejo region was chosen for its simple tectonic setting and also because the relationship between seismicity, tectonics and local lithospheric structure is intriguing and still poorly understood. Inside the target area the seismicity clusters mainly within two clouds, oriented SE-NW and SW-NE. Should these clusters be seen as the expression of local active faults? Are they associated to lithological transitions? Or do the locations obtained from the previously sparse permanent network have large errors and generate fake clusters? We present preliminary results from this study, and compare them with manual locations. This work is supported by project QuakeLoc, reference: PTDC/GEO-FIQ/3522/2012

Clinical Study of Orthogonal-View Phase-Matched Digital Tomosynthesis for Lung Tumor Localization.

PubMed

Zhang, You; Ren, Lei; Vergalasova, Irina; Yin, Fang-Fang

2017-01-01

Compared to cone-beam computed tomography, digital tomosynthesis imaging has the benefits of shorter scanning time, less imaging dose, and better mechanical clearance for tumor localization in radiation therapy. However, for lung tumors, the localization accuracy of the conventional digital tomosynthesis technique is affected by the lack of depth information and the existence of lung tumor motion. This study investigates the clinical feasibility of using an orthogonal-view phase-matched digital tomosynthesis technique to improve the accuracy of lung tumor localization. The proposed orthogonal-view phase-matched digital tomosynthesis technique benefits from 2 major features: (1) it acquires orthogonal-view projections to improve the depth information in reconstructed digital tomosynthesis images and (2) it applies respiratory phase-matching to incorporate patient motion information into the synthesized reference digital tomosynthesis sets, which helps to improve the localization accuracy of moving lung tumors. A retrospective study enrolling 14 patients was performed to evaluate the accuracy of the orthogonal-view phase-matched digital tomosynthesis technique. Phantom studies were also performed using an anthropomorphic phantom to investigate the feasibility of using intratreatment aggregated kV and beams' eye view cine MV projections for orthogonal-view phase-matched digital tomosynthesis imaging. The localization accuracy of the orthogonal-view phase-matched digital tomosynthesis technique was compared to that of the single-view digital tomosynthesis techniques and the digital tomosynthesis techniques without phase-matching. The orthogonal-view phase-matched digital tomosynthesis technique outperforms the other digital tomosynthesis techniques in tumor localization accuracy for both the patient study and the phantom study. For the patient study, the orthogonal-view phase-matched digital tomosynthesis technique localizes the tumor to an average (± standard deviation) error of 1.8 (0.7) mm for a 30° total scan angle. For the phantom study using aggregated kV-MV projections, the orthogonal-view phase-matched digital tomosynthesis localizes the tumor to an average error within 1 mm for varying magnitudes of scan angles. The pilot clinical study shows that the orthogonal-view phase-matched digital tomosynthesis technique enables fast and accurate localization of moving lung tumors.

Local conservation laws and the structure of the many-body localized states.

PubMed

Serbyn, Maksym; Papić, Z; Abanin, Dmitry A

2013-09-20

We construct a complete set of local integrals of motion that characterize the many-body localized (MBL) phase. Our approach relies on the assumption that local perturbations act locally on the eigenstates in the MBL phase, which is supported by numerical simulations of the random-field XXZ spin chain. We describe the structure of the eigenstates in the MBL phase and discuss the implications of local conservation laws for its nonequilibrium quantum dynamics. We argue that the many-body localization can be used to protect coherence in the system by suppressing relaxation between eigenstates with different local integrals of motion.

Nanoscale Packing Differences in Sphingomyelin and Phosphatidylcholine Revealed by BODIPY Fluorescence in Monolayers: Physiological Implications

PubMed Central

2015-01-01

Phosphatidycholines (PC) with two saturated acyl chains (e.g., dipalmitoyl) mimic natural sphingomyelin (SM) by promoting raft formation in model membranes. However, sphingoid-based lipids, such as SM, rather than saturated-chain PCs have been implicated as key components of lipid rafts in biomembranes. These observations raise questions about the physical packing properties of the phase states that can be formed by these two major plasma membrane lipids with identical phosphocholine headgroups. To investigate, we developed a monolayer platform capable of monitoring changes in surface fluorescence by acquiring multiple spectra during measurement of a lipid force–area isotherm. We relied on the concentration-dependent emission changes of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-labeled PC to detect nanoscale alterations in lipid packing and phase state induced by monolayer lateral compression. The BODIPY-PC probe contained an indacene ring with four symmetrically located methyl (Me) substituents to enhance localization to the lipid hydrocarbon region. Surface fluorescence spectra indicated changes in miscibility even when force–area isotherms showed no deviation from ideal mixing behavior in the surface pressure versus cross-sectional molecular area response. We detected slightly better mixing of Me4-BODIPY-8-PC with the fluid-like, liquid expanded phase of 1-palmitoyl-2-oleoyl-PC compared to N-oleoyl-SM. Remarkably, in the gel-like, liquid condensed phase, Me4-BODIPY-8-PC mixed better with N-palmitoyl-SM than dipalmitoyl-PC, suggesting naturally abundant SMs with saturated acyl chains form gel-like lipid phase(s) with enhanced ability to accommodate deeply embedded components compared to dipalmitoyl-PC gel phase. The findings reveal a fundamental difference in the lateral packing properties of SM and PC that occurs even when their acyl chains match. PMID:24564829

Self-assembly of gelator molecules in liquid crystals studied by ESR

NASA Astrophysics Data System (ADS)

Andreis, Mladen; Carić, Dejana; Vujičić, Nataša Šijaković; Jokić, Milan; Žinić, Mladen; Kveder, Marina

2012-07-01

Thermotropic liquid crystal trans-4-heptylcyclohexanecarboxylic acid (HCCA) doped with 4-oxo-2,2,6,6,-tetramethyl-1-piperidinyloxy spin probe (Tempone) is investigated by electron spin resonance (ESR) spectroscopy in the presence of chiral bisoxalamide gelator 1 during both cooling and heating cycles. In the temperature range 295-383 K, where HCCA displays isotropic, nematic, smectic B and crystalline phases, the impact of 1 self-organization was detected via (non) homogeneous partitioning of the spin probe in the environments varying in the polarity, an effect dependent on the gelator concentration. In particular, the evidence of the onset of the gelator network self-assembly in the nematic phase was detected by ESR at higher temperatures than the ones reported so far by other experimental techniques. Additionally, the spectral analysis points to the switching of the polarity in the vicinity of the spin probe when the transfer of chirality from 1 to HCCA upon cooling of the sample from isotropic to chiral nematic phase appears and when the event of LC gelation results in the achiral nematic phase during chiral gel fibers formation. When the gelation proceeds in the smectic phase, the melting of the gelator network is studied in the nematic phase during the heating cycle. Furthermore, the event of HCCA crystallization is shown to be strongly affected by the presence of 1 as well. The experimental evidence is provided that gelator network confines the HCCA into the domains within the bulk crystalline matrix where the local molecular dynamics are still not frozen. Therefore, we propose that non-homogeneous polarity profile of molecular organization/packing within LC gels could be determinable for the physical properties of various LC gel phases.

Shearlet-based edge detection: flame fronts and tidal flats

NASA Astrophysics Data System (ADS)

King, Emily J.; Reisenhofer, Rafael; Kiefer, Johannes; Lim, Wang-Q.; Li, Zhen; Heygster, Georg

2015-09-01

Shearlets are wavelet-like systems which are better suited for handling geometric features in multi-dimensional data than traditional wavelets. A novel method for edge and line detection which is in the spirit of phase congruency but is based on a complex shearlet transform will be presented. This approach to detection yields an approximate tangent direction of detected discontinuities as a byproduct of the computation, which then yields local curvature estimates. Two applications of the edge detection method will be discussed. First, the tracking and classification of flame fronts is a critical component of research in technical thermodynamics. Quite often, the flame fronts are transient or weak and the images are noisy. The standard methods used in the field for the detection of flame fronts do not handle such data well. Fortunately, using the shearlet-based edge measure yields good results as well as an accurate approximation of local curvature. Furthermore, a modification of the method will yield line detection, which is important for certain imaging modalities. Second, the Wadden tidal flats are a biodiverse region along the North Sea coast. One approach to surveying the delicate region and tracking the topographical changes is to use pre-existing Synthetic Aperture Radar (SAR) images. Unfortunately, SAR data suffers from multiplicative noise as well as sensitivity to environmental factors. The first large-scale mapping project of that type showed good results but only with a tremendous amount of manual interaction because there are many edges in the data which are not boundaries of the tidal flats but are edges of features like fields or islands. Preliminary results will be presented.

HacDivSel: Two new methods (haplotype-based and outlier-based) for the detection of divergent selection in pairs of populations

PubMed Central

2017-01-01

The detection of genomic regions involved in local adaptation is an important topic in current population genetics. There are several detection strategies available depending on the kind of genetic and demographic information at hand. A common drawback is the high risk of false positives. In this study we introduce two complementary methods for the detection of divergent selection from populations connected by migration. Both methods have been developed with the aim of being robust to false positives. The first method combines haplotype information with inter-population differentiation (FST). Evidence of divergent selection is concluded only when both the haplotype pattern and the FST value support it. The second method is developed for independently segregating markers i.e. there is no haplotype information. In this case, the power to detect selection is attained by developing a new outlier test based on detecting a bimodal distribution. The test computes the FST outliers and then assumes that those of interest would have a different mode. We demonstrate the utility of the two methods through simulations and the analysis of real data. The simulation results showed power ranging from 60–95% in several of the scenarios whilst the false positive rate was controlled below the nominal level. The analysis of real samples consisted of phased data from the HapMap project and unphased data from intertidal marine snail ecotypes. The results illustrate that the proposed methods could be useful for detecting locally adapted polymorphisms. The software HacDivSel implements the methods explained in this manuscript. PMID:28423003

Electrical conductivity, differential scanning calorimetry, X-ray diffraction, and 7Li nuclear magnetic resonance studies of n-C x H(2 x+1)OSO3Li ( x = 12, 14, 16, 18, and 20)

NASA Astrophysics Data System (ADS)

Hirakawa, Satoru; Morimoto, Yoshiaki; Honda, Hisashi

2015-04-01

Electrical conductivity ( σ), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) measurements of n-C x H (2 x+1) OSO 3Li ( x= 12, 14, 16, 18, and 20) crystals were performed as a function of temperature. In addition, σ, DSC, and XRD observations of n-C x H (2 x+1) OSO 3Na and n-C x H (2 x+1) OSO 3K ( x= 12, 14, 16, 18, and 20) crystals were carried out for comparison. DSC results of the salts revealed several solid-solid phase transitions with large entropy changes (Δ S). For n-C 18 H 37 OSO 3Li and n-C 20 H 41 OSO 3Li salts, each melting point produced a small Δ S mp value compared with the total entropy change in the solid phases (Δ S tr1+Δ S tr2). Additionally, Li + ion diffusion was detected in the highest temperature solid phases. For K salts, larger σ values were detected for potassium alkylsulfates compared with those reported for alkyl carboxylate. 7Li NMR spectra of n-C 18 H 37 OSO 3Li crystals recorded in the low-temperature phase showed large asymmetry parameters, suggesting the Li + ions are localized at asymmetric sites in the crystals.

Characterizing Time Irreversibility in Disordered Fermionic Systems by the Effect of Local Perturbations

NASA Astrophysics Data System (ADS)

Vardhan, Shreya; De Tomasi, Giuseppe; Heyl, Markus; Heller, Eric J.; Pollmann, Frank

2017-07-01

We study the effects of local perturbations on the dynamics of disordered fermionic systems in order to characterize time irreversibility. We focus on three different systems: the noninteracting Anderson and Aubry-André-Harper (AAH) models and the interacting spinless disordered t -V chain. First, we consider the effect on the full many-body wave functions by measuring the Loschmidt echo (LE). We show that in the extended or ergodic phase the LE decays exponentially fast with time, while in the localized phase the decay is algebraic. We demonstrate that the exponent of the decay of the LE in the localized phase diverges proportionally to the single-particle localization length as we approach the metal-insulator transition in the AAH model. Second, we probe different phases of disordered systems by studying the time expectation value of local observables evolved with two Hamiltonians that differ by a spatially local perturbation. Remarkably, we find that many-body localized systems could lose memory of the initial state in the long-time limit, in contrast to the noninteracting localized phase where some memory is always preserved.

The Measurement of the Effects of Helmet Form on Sound Source Detection and Localization Using a Portable Four-Loudspeaker Test Array

DTIC Science & Technology

2013-05-01

to data collection, a rough estimate of each listener’s binaural hearing threshold (with a bare head) was obtained for each of the test frequencies...spectral information that allows disambiguation of binaural cues lies primarily in the higher frequencies. For the analysis shown in the second...Moore, 2012). The binaural cues of level and phase differences are fairly robust; however, they can only help to determine locations on the left-right

Laser-irradiated Kondo insulators: Controlling the Kondo effect and topological phases

NASA Astrophysics Data System (ADS)

Takasan, Kazuaki; Nakagawa, Masaya; Kawakami, Norio

2017-09-01

We investigate theoretically the nature of laser-irradiated Kondo insulators. Using Floquet theory and the slave-boson approach, we study a periodic Anderson model and derive an effective model that describes laser-irradiated Kondo insulators. In this model, we find two generic effects induced by laser light. One is dynamical localization, which suppresses hopping and hybridization. The other is laser-induced hopping and hybridization, which can be interpreted as synthetic spin-orbit coupling or a magnetic field. The first effect drastically changes the behavior of the Kondo effect. In particular, the Kondo effect under laser light qualitatively changes its character depending on whether the hybridization is on-site or off-site. The second effect triggers topological phase transitions. In topological Kondo insulators, linearly polarized laser light realizes phase transitions between trivial, weak topological, and strong topological Kondo insulators. Moreover, circularly polarized laser light breaks time-reversal symmetry and induces Weyl semimetallic phases. Our results make it possible to dynamically control the Kondo effect and topological phases in heavy-fermion systems. We also discuss experimental setups to detect the signatures.

Ultrafast optical excitation of magnetic skyrmions

NASA Astrophysics Data System (ADS)

Ogawa, N.; Seki, S.; Tokura, Y.

2015-04-01

Magnetic skyrmions in an insulating chiral magnet Cu2OSeO3 were studied by all-optical spin wave spectroscopy. The spins in the conical and skyrmion phases were excited by the impulsive magnetic field from the inverse-Faraday effect, and resultant spin dynamics were detected by using time-resolved magneto-optics. Clear dispersions of the helimagnon were observed, which is accompanied by a distinct transition into the skyrmion phase, by sweeping temperature and magnetic field. In addition to the collective excitations of skyrmions, i.e., rotation and breathing modes, several spin precession modes were identified, which would be specific to optical excitation. The ultrafast, nonthermal, and local excitation of the spin systems by photons would lead to the efficient manipulation of nano-magnetic structures.

Optical Electronic Bragg Reflection Sensor System with Hydrodynamic Flow Applications

NASA Technical Reports Server (NTRS)

Lyons, D. R.

2003-01-01

This project, as described in the following report, involved design and fabrication of fiber optic sensors for the detection and measurement of dynamic fluid density variations. These devices are created using UV (ultraviolet) ablation and generally modified transverse holographic fiber grating techniques. The resulting phase gratings created on or immediately underneath the flat portion of D-shaped optical waveguides are characterized as evanescent field sensing devices. The primary applications include the sensor portion of a real-time localized or distributed measurement system for hydrodynamic flow, fluid density measurements, and phase change phenomena. Several design modifications were implemented in an attempt to accomplish the tasks specified in our original proposal. In addition, we have established key collaborative relationships with numerous people and institutions.

Controlling the shapes and sizes of metallic nanoantennas for detection of biological molecules using hybridization phase of plasmon resonances and photonic lattice modes

NASA Astrophysics Data System (ADS)

Gutha, Rithvik R.; Sharp, Christina; Wing, Waylin J.; Sadeghi, Seyed M.

2018-02-01

Chemical sensing based on Localized Surface Plasmonic Resonances (LSPR) and the ultra-sharp optical features of surface lattice resonances (SLR) of arrays of metallic nanoantennas have attracted much attention. Recently we studied biosensing based on the transition between LSPR and SLR (hybridization phase), demonstrating significantly higher refractive index sensitivity than each of these resonances individually. In this contribution we study the impact of size and shape of the metallic nanoantennas on the hybridization process and the way they influence application of this process for biosensing, wherein miniscule variation of the refractive index of the environment leads to dramatic changes in the spectral properties of the arrays.

Optical Links and RF Distribution for Antenna Arrays

NASA Technical Reports Server (NTRS)

Huang, Shouhua; Calhoun, Malcolm; Tjoelker, Robert

2006-01-01

An array of three antennas has recently been developed at the NASA Jet Propulsion Laboratory capable of detecting signals at X and Ka band. The array requires a common frequency reference and high precision phase alignment to correlate received signals. Frequency and timing references are presently provided from a remotely located hydrogen maser and clock through a combination of commercially and custom developed optical links. The selected laser, photodetector, and fiber components have been tested under anticipated thermal and simulated antenna rotation conditions. The resulting stability limitations due to thermal perturbations or induced stress on the optical fiber have been characterized. Distribution of the X band local oscillator includes a loop back and precision phase monitor to enable correlation of signals received from each antenna.

Local-Scale Simulations of Nucleate Boiling on Micrometer Featured Surfaces: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sitaraman, Hariswaran; Moreno, Gilberto; Narumanchi, Sreekant V

2017-08-03

A high-fidelity computational fluid dynamics (CFD)-based model for bubble nucleation of the refrigerant HFE7100 on micrometer-featured surfaces is presented in this work. The single-fluid incompressible Navier-Stokes equations, along with energy transport and natural convection effects are solved on a featured surface resolved grid. An a priori cavity detection method is employed to convert raw profilometer data of a surface into well-defined cavities. The cavity information and surface morphology are represented in the CFD model by geometric mesh deformations. Surface morphology is observed to initiate buoyancy-driven convection in the liquid phase, which in turn results in faster nucleation of cavities. Simulationsmore » pertaining to a generic rough surface show a trend where smaller size cavities nucleate with higher wall superheat. This local-scale model will serve as a self-consistent connection to larger device scale continuum models where local feature representation is not possible.« less

Local-Scale Simulations of Nucleate Boiling on Micrometer-Featured Surfaces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sitaraman, Hariswaran; Moreno, Gilberto; Narumanchi, Sreekant V

2017-07-12

A high-fidelity computational fluid dynamics (CFD)-based model for bubble nucleation of the refrigerant HFE7100 on micrometer-featured surfaces is presented in this work. The single-fluid incompressible Navier-Stokes equations, along with energy transport and natural convection effects are solved on a featured surface resolved grid. An a priori cavity detection method is employed to convert raw profilometer data of a surface into well-defined cavities. The cavity information and surface morphology are represented in the CFD model by geometric mesh deformations. Surface morphology is observed to initiate buoyancy-driven convection in the liquid phase, which in turn results in faster nucleation of cavities. Simulationsmore » pertaining to a generic rough surface show a trend where smaller size cavities nucleate with higher wall superheat. This local-scale model will serve as a self-consistent connection to larger device scale continuum models where local feature representation is not possible.« less

Locally preserved α  →  β phase transition in natural radiation-damaged titanite (CaTiSiO5): evidence from laser-induced photoluminescence and dielectric measurements

NASA Astrophysics Data System (ADS)

Beirau, Tobias; Murawski, Dawid; Behrens, Harald; Salje, Ekhard K. H.; Groat, Lee A.; Kaden, Ronny; Pöllmann, Herbert; Bismayer, Ulrich

2018-01-01

In situ temperature-dependent laser-induced photoluminescence and dielectric measurements provide new evidence for the local occurrence of the α  →  β phase transition near 500 K in the preserved crystalline parts of natural radiation-damaged titanite (sample E2335 with ~24% amorphous fraction, containing Fe and Al impurities). Photoluminescence spectroscopic measurements show an anomaly in the vicinity of 500 K. The temperature-dependent evolution of the real part of the electrical conductivity (σ) and the real (ɛ‧) and the imaginary (ɛ″) part of the complex dielectric permittivity (ɛ *) of titanite have been measured at various AC frequencies (~1.2-96.8 kHz). Despite the masking and smearing effect of impurities and defects, the temperature-dependent behaviour of ɛ‧ and ɛ″ around the transition temperature of the investigated natural titanite E2335 shows a remarkable similarity to that of the synthetic end-member material (see Zhang et al (1995 Phys. Chem. Miner. 22 41-9)). This study indicates the suitability of photoluminescence and impedance spectroscopy for the detection of phase transitions, even in heavily disordered systems.

High Resolution Deformation Time Series Estimation for Distributed Scatterers Using Terrasar-X Data

NASA Astrophysics Data System (ADS)

Goel, K.; Adam, N.

2012-07-01

In recent years, several SAR satellites such as TerraSAR-X, COSMO-SkyMed and Radarsat-2 have been launched. These satellites provide high resolution data suitable for sophisticated interferometric applications. With shorter repeat cycles, smaller orbital tubes and higher bandwidth of the satellites; deformation time series analysis of distributed scatterers (DSs) is now supported by a practical data basis. Techniques for exploiting DSs in non-urban (rural) areas include the Small Baseline Subset Algorithm (SBAS). However, it involves spatial phase unwrapping, and phase unwrapping errors are typically encountered in rural areas and are difficult to detect. In addition, the SBAS technique involves a rectangular multilooking of the differential interferograms to reduce phase noise, resulting in a loss of resolution and superposition of different objects on ground. In this paper, we introduce a new approach for deformation monitoring with a focus on DSs, wherein, there is no need to unwrap the differential interferograms and the deformation is mapped at object resolution. It is based on a robust object adaptive parameter estimation using single look differential interferograms, where, the local tilts of deformation velocity and local slopes of residual DEM in range and azimuth directions are estimated. We present here the technical details and a processing example of this newly developed algorithm.

Simultaneous scanning tunneling microscopy and synchrotron X-ray measurements in a gas environment.

PubMed

Mom, Rik V; Onderwaater, Willem G; Rost, Marcel J; Jankowski, Maciej; Wenzel, Sabine; Jacobse, Leon; Alkemade, Paul F A; Vandalon, Vincent; van Spronsen, Matthijs A; van Weeren, Matthijs; Crama, Bert; van der Tuijn, Peter; Felici, Roberto; Kessels, Wilhelmus M M; Carlà, Francesco; Frenken, Joost W M; Groot, Irene M N

2017-11-01

A combined X-ray and scanning tunneling microscopy (STM) instrument is presented that enables the local detection of X-ray absorption on surfaces in a gas environment. To suppress the collection of ion currents generated in the gas phase, coaxially shielded STM tips were used. The conductive outer shield of the coaxial tips can be biased to deflect ions away from the tip core. When tunneling, the X-ray-induced current is separated from the regular, 'topographic' tunneling current using a novel high-speed separation scheme. We demonstrate the capabilities of the instrument by measuring the local X-ray-induced current on Au(1 1 1) in 800 mbar Ar. Copyright © 2017 Elsevier B.V. All rights reserved.

Bat detective—Deep learning tools for bat acoustic signal detection

PubMed Central

Barlow, Kate E.; Firman, Michael; Freeman, Robin; Harder, Briana; Kinsey, Libby; Mead, Gary R.; Newson, Stuart E.; Pandourski, Ivan; Russ, Jon; Szodoray-Paradi, Abigel; Tilova, Elena; Girolami, Mark; Jones, Kate E.

2018-01-01

Passive acoustic sensing has emerged as a powerful tool for quantifying anthropogenic impacts on biodiversity, especially for echolocating bat species. To better assess bat population trends there is a critical need for accurate, reliable, and open source tools that allow the detection and classification of bat calls in large collections of audio recordings. The majority of existing tools are commercial or have focused on the species classification task, neglecting the important problem of first localizing echolocation calls in audio which is particularly problematic in noisy recordings. We developed a convolutional neural network based open-source pipeline for detecting ultrasonic, full-spectrum, search-phase calls produced by echolocating bats. Our deep learning algorithms were trained on full-spectrum ultrasonic audio collected along road-transects across Europe and labelled by citizen scientists from www.batdetective.org. When compared to other existing algorithms and commercial systems, we show significantly higher detection performance of search-phase echolocation calls with our test sets. As an example application, we ran our detection pipeline on bat monitoring data collected over five years from Jersey (UK), and compared results to a widely-used commercial system. Our detection pipeline can be used for the automatic detection and monitoring of bat populations, and further facilitates their use as indicator species on a large scale. Our proposed pipeline makes only a small number of bat specific design decisions, and with appropriate training data it could be applied to detecting other species in audio. A crucial novelty of our work is showing that with careful, non-trivial, design and implementation considerations, state-of-the-art deep learning methods can be used for accurate and efficient monitoring in audio. PMID:29518076

Absolute phase estimation: adaptive local denoising and global unwrapping.

PubMed

Bioucas-Dias, Jose; Katkovnik, Vladimir; Astola, Jaakko; Egiazarian, Karen

2008-10-10

The paper attacks absolute phase estimation with a two-step approach: the first step applies an adaptive local denoising scheme to the modulo-2 pi noisy phase; the second step applies a robust phase unwrapping algorithm to the denoised modulo-2 pi phase obtained in the first step. The adaptive local modulo-2 pi phase denoising is a new algorithm based on local polynomial approximations. The zero-order and the first-order approximations of the phase are calculated in sliding windows of varying size. The zero-order approximation is used for pointwise adaptive window size selection, whereas the first-order approximation is used to filter the phase in the obtained windows. For phase unwrapping, we apply the recently introduced robust (in the sense of discontinuity preserving) PUMA unwrapping algorithm [IEEE Trans. Image Process.16, 698 (2007)] to the denoised wrapped phase. Simulations give evidence that the proposed algorithm yields state-of-the-art performance, enabling strong noise attenuation while preserving image details. (c) 2008 Optical Society of America

New approach for local cancer treatment using pulsed high-intensity focused ultrasound and phase-change nanodroplets.

PubMed

Ashida, Reiko; Kawabata, Ken-Ichi; Maruoka, Takashi; Asami, Rei; Yoshikawa, Hideki; Takakura, Rena; Ioka, Tatsuya; Katayama, Kazuhiro; Tanaka, Sachiko

2015-10-01

The aim of this study was to investigate the combination effects of pulsed HIFU (pHIFU) and phase-change nanodroplets (PCND) as a sensitizer on efficient induction of mechanical effects of pHIFU and chemically enhanced tumor growth inhibition for local anti-tumor therapy. Changes in growth of colon 26 tumor tissue inoculated onto CDF1 mice were evaluated by the following treatments. (1) pHIFU exposure (1.1 MHz, 3.2 kW/cm(2), 300 cycles, and 50 ms interval) for 60 s, (2) PCND (1 %) injection, (3) adriamycin (4 mg/kg) injection, (4) pHIFU exposure after PCND injection, and (5) pHIFU exposure after PCND + adriamycin injection simultaneously. Significant changes in tumor growth were observed in the group with combination of pHIFU and PCND, although single therapy did not show any significant difference. PCND enhanced mechanical tissue fractionation by pHIFU, which was detectable by Real-time tissue elastography. Moreover, the combination of pHIFU and PCND + Adriamycin suppressed the tumor growth for 2 weeks, and 3 of 4 mice did not show any sign of regrowth during the 30-day observation. The combination of pHIFU and PCND exerted a significant anti-tumor effect and may be a new candidate for treatment of locally advanced cancer.

Nuclear localization signal-dependent and -independent movements of Drosophila melanogaster dUTPase isoforms during nuclear cleavage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Muha, Villo; Zagyva, Imre; Venkei, Zsolt

2009-04-03

Two dUTPase isoforms (23 kDa and 21 kDa) are present in the fruitfly with the sole difference of an N-terminal extension. In Drosophila embryo, both isoforms are detected inside the nucleus. Here, we investigated the function of the N-terminal segment using eYFP-dUTPase constructs. In Schneider 2 cells, only the 23 kDa construct showed nuclear localization arguing that it may contain a nuclear localization signal (NLS). Sequence comparisons identified a lysine-rich nonapeptide with similarity to the human c-myc NLS. In Drosophila embryos during nuclear cleavages, the 23 kDa isoform showed the expected localization shifts. Contrariwise, although the 21 kDa isoform wasmore » excluded from the nuclei during interphase, it was shifted to the nucleus during prophase and forthcoming mitotic steps. The observed dynamic localization character showed strict timing to the nuclear cleavage phases and explained how both isoforms can be present within the nuclear microenvironment, although at different stages of cell cycle.« less

Exploring the Chemical Link Between Local Ellipticals and Their High-Redshift Progenitors

NASA Technical Reports Server (NTRS)

Leja, Joel; Van Dokkum, Pieter G.; Momcheva, Ivelina; Brammer, Gabriel; Skelton, Rosalind E.; Whitaker, Katherine E.; Andrews, Brett H.; Franx, Marijn; Kriek, Mariska; Van Der Wel, Arjen;

Quantum order, entanglement and localization in many-body systems

NASA Astrophysics Data System (ADS)

Khemani, Vedika

The interplay of disorder and interactions can have remarkable effects on the physics of quantum systems. A striking example is provided by the long conjectured--and recently confirmed--phenomenon of many-body localization. Many-body localized (MBL) phases violate foundational assumptions about ergodicity and thermalization in interacting systems, and represent a new frontier for non-equilibrium quantum statistical mechanics. We start with a study of the dynamical response of MBL phases to time-dependent perturbations. We find that that an asymptotically slow, local perturbation induces a highly non-local response, a surprising result for a localized insulator. A complementary calculation in the linear-response regime elucidates the structure of many-body resonances contributing to the dynamics of this phase. We then turn to a study of quantum order in MBL systems. It was shown that localization can allow novel high-temperature phases and phase transitions that are disallowed in equilibrium. We extend this idea of "localization protected order'' to the case of symmetry-protected topological phases and to the elucidation of phase structure in periodically driven Floquet systems. We show that Floquet systems can display nontrivial phases, some of which show a novel form of correlated spatiotemporal order and are absolutely stable to all generic perturbations. The next part of the thesis addresses the role of quantum entanglement, broadly speaking. Remarkably, it was shown that even highly-excited MBL eigenstates have low area-law entanglement. We exploit this feature to develop tensor-network based algorithms for efficiently computing and representing highly-excited MBL eigenstates. We then switch gears from disordered, localized systems and examine the entanglement Hamiltonian and its low energy spectrum from a statistical mechanical lens, particularly focusing on issues of universality and thermalization. We close with two miscellaneous results on topologically ordered phases. The first studies the nonequilibrium "Kibble-Zurek'' dynamics resulting from driving a system through a phase transition from a topologically ordered phase to a trivial one at a finite rate. The second shows that the four-state Potts model on the pyrochlore lattice exhibits a "Coulomb Phase'' characterized by three emergent gauge fields.

“Direct” Gas-phase Metallicity in Local Analogs of High-redshift Galaxies: Empirical Metallicity Calibrations for High-redshift Star-forming Galaxies

NASA Astrophysics Data System (ADS)

Bian, Fuyan; Kewley, Lisa J.; Dopita, Michael A.

2018-06-01

We study the direct gas-phase oxygen abundance using the well-detected auroral line [O III]λ4363 in the stacked spectra of a sample of local analogs of high-redshift galaxies. These local analogs share the same location as z ∼ 2 star-forming galaxies on the [O III]λ5007/Hβ versus [N II]λ6584/Hα Baldwin–Phillips–Terlevich diagram. This type of analog has the same ionized interstellar medium (ISM) properties as high-redshift galaxies. We establish empirical metallicity calibrations between the direct gas-phase oxygen abundances (7.8< 12+{log}({{O}}/{{H}})< 8.4) and the N2 (log([N II]λ6584/Hα))/O3N2 (log(([O III]λ5007/Hβ)/([N II]λ6584/Hα))) indices in our local analogs. We find significant systematic offsets between the metallicity calibrations for our local analogs of high-redshift galaxies and those derived from the local H II regions and a sample of local reference galaxies selected from the Sloan Digital Sky Survey (SDSS). The N2 and O3N2 metallicities will be underestimated by 0.05–0.1 dex relative to our calibration, if one simply applies the local metallicity calibration in previous studies to high-redshift galaxies. Local metallicity calibrations also cause discrepancies of metallicity measurements in high-redshift galaxies using the N2 and O3N2 indicators. In contrast, our new calibrations produce consistent metallicities between these two indicators. We also derive metallicity calibrations for R23 (log(([O III]λλ4959,5007+[O II]λλ3726,3729)/Hβ)), O32(log([O III]λλ4959,5007/[O II]λλ3726,3729)), {log}([O III]λ5007/Hβ), and log([Ne III]λ3869/[O II]λ3727) indices in our local analogs, which show significant offset compared to those in the SDSS reference galaxies. By comparing with MAPPINGS photoionization models, the different empirical metallicity calibration relations in the local analogs and the SDSS reference galaxies can be shown to be primarily due to the change of ionized ISM conditions. Assuming that temperature structure variations are minimal and ISM conditions do not change dramatically from z ∼ 2 to z ∼ 5, these empirical calibrations can be used to measure relative metallicities in galaxies with redshifts up to z ∼ 5.0 in ground-based observations.

[Imaging origins and characteristics analysis of acute and chronic aspiration pneumonia].

PubMed

Wang, Kang; Li, Ming; Wang, Xiongbiao; Qin, Jianmin; Wang, Zhi; Zhao, Zehua; Qin, Le; Hua, Yanqing

2014-11-11

To discuss about the pathologic and imaging origins and characteristics of CT scaning and X-ray radiography for acute and chronic aspiration pneumonia. Imaging data from 30 patients with aspiration pneumonia were retrospectively analyzed, CT scaning was performed in 27 patients, which PMVR reconstruction was performed in 21 cases;3 exammed by X-ray with 2 used by esophagography. Opaque bodies were detected in trachea by CT scaning in 12 patients.7 patients in acute phase rapidly developed into acute respiratory distress syndrome(ARDS). CT signs of 30 patients with acute and chronic aspiration pneumonia included: centrilobular nodules were detected in 2 cases with acute phase, 4 cases with subacute phase and 4 cases with chronic phase; the imaging of ground glass opacity were detected in 9 cases with acute phase, 2 cases with subacute phase and 3 cases with chronic phase; the imaging of bronchiectasis was detected in 8 cases with chronic phase, which mucilage embolism was detected in 3 of 8 cases; the imaging of atelectasis was detected in 6 cases with chronic phase; the imaging of sheeted consolidation was detected in 5 cases with chronic phase, 8 case with acute phase; the imaging of interstitial fibrosis was detected in 3 cases with chronic phase. Lesions of inferior lobe of right lung were detected in 9 cases with chronic phase, 4 cases with subacute phase, 11 case with acute phase;lesions of inferior lobe of left lung were detected in 6 cases with chronic phase and 3 cases with subacute group, 11 case with acute phase. The imaging features of acute and chronic aspiration pneumonia overlap with GGO and centrilobular nodules in every group. While the imaging features of atelectasis, bronchiectasis or mucilage embolism are found in chronic phase. The chest CT scaning may accurately evaluate the dynamic change of aspiration pneumonia.

Late Pleistocene - Holocene surface processes and landscape evolution in the central Swiss Alps

NASA Astrophysics Data System (ADS)

Boxleitner, Max; Musso, Alessandra; Waroszewski, Jarosław; Malkiewicz, Małgorzata; Maisch, Max; Dahms, Dennis; Brandová, Dagmar; Christl, Marcus; de Castro Portes, Raquel; Egli, Markus

2017-10-01

The European Alps are a geomorphologically active region and experience a number of gravity-driven hillslope processes. Soil and landscape formation in the Alps has consequently undergone several minor and major traceable changes of developmental trajectories during the Holocene. Soil development is hypothesised to be often non-linear with time and characterised by stages of progressive and regressive evolution caused by upbuilding (formation, profile deepening) and erosion (profile shallowing). Several cold and warm climate phases are identified during the Holocene but it is largely unknown which effects these might have had on slope processes. By using datable moraines (10Be) and mires (14C), we have constructed a temporal framework for these processes. Using the geochemical imprint of mires in the Alpine setting of the Göschener-valley of the Central Swiss Alps, we reconstructed general (mostly erosional) landscape processes for the last ca. 10 ka. As this is the type locality for the Göschener cold phase, we assumed that this phase (Göschener cold phase I and II 1.5 and 2.5 ka BP) should have left easily recognizable traits. After deglaciation (11-12 ka BP), soil evolution was progressive. Beginning around 8 ka BP, we detect a distinct increase in erosion here, together with a vegetation change (towards tundra vegetation) and the highest measured rates of carbon sequestration. Other phases of high geomorphic activity were recognised ca. 5-6 ka BP, 4 ka BP and, to a lesser extent, 1-3 ka ago. The cold phase at 5-6 ka BP corresponds to a less distinct change in vegetation and lessened erosion. Human impact is increasingly obvious since about 2.4 ka BP which overlaps with the Göschener cold phase. Nonetheless, erosion processes were not extraordinarily high during this period and a climate effect cannot be distinguished. We detect evidence of increasing human disturbance (regressive soil evolution) for about the last 1 ka. We also detect an increase in dust flux during the last ca. 4-5 ka, presumably due to the landscape change(s) in the Sahara during this time.

Dispersive Phase in the L-band InSAR Image Associated with Heavy Rain Episodes

NASA Astrophysics Data System (ADS)

Furuya, M.; Kinoshita, Y.

2017-12-01

Interferometric synthetic aperture radar (InSAR) is a powerful geodetic technique that allows us to detect ground displacements with unprecedented spatial resolution, and has been used to detect displacements due to earthquakes, volcanic eruptions, and glacier motion. In the meantime, due to the microwave propagation through ionosphere and troposphere, we often encounter non-negligible phase anomaly in InSAR data. Correcting for the ionsphere and troposphere is therefore a long-standing issue for high-precision geodetic measurements. However, if ground displacements are negligible, InSAR image can tell us the details of the atmosphere.Kinoshita and Furuya (2017, SOLA) detected phase anomaly in ALOS/PALSAR InSAR data associated with heavy rain over Niigata area, Japan, and performed numerical weathr model simulation to reproduce the anomaly; ALOS/PALSAR is a satellite-based L-band SAR sensor launched by JAXA in 2006 and terminated in 2011. The phase anomaly could be largely reproduced, using the output data from the weather model. However, we should note that numerical weather model outputs can only account for the non-dispersive effect in the phase anomaly. In case of severe weather event, we may expect dispersive effect that could be caused by the presence of free-electrons.In Global Navigation Satellite System (GNSS) positioning, dual frequency measurements allow us to separate the ionospheric dispersive component from tropospheric non-dispersive components. In contrast, SAR imaging is based on a single carrier frequency, and thus no operational ionospheric corrections have been performed in InSAR data analyses. Recently, Gomba et al (2016) detailed the processing strategy of split spectrum method (SSM) for InSAR, which splits the finite bandwidth of the range spectrum and virtually allows for dual-frequency measurements.We apply the L-band InSAR SSM to the heavy rain episodes, in which more than 50 mm/hour precipitations were reported. We report the presence of phase anomaly in both dispersive and non-dispersive components. While the original phase anomaly turns out to be mostly due to the non-dispersive effect, we could recognize local anomalies in the dispersive component as well. We will discuss its geophysical implications, and may show several case studies.

Auto correlation analysis of coda waves from local earthquakes for detecting temporal changes in shallow subsurface structures - The 2011 Tohoku-Oki, Japan, earthquake -

NASA Astrophysics Data System (ADS)

Nakahara, H.

2013-12-01

For monitoring temporal changes in subsurface structures, I propose to use auto correlation functions of coda waves from local earthquakes recorded at surface receivers, which probably contain more body waves than surface waves. Because the use of coda waves requires earthquakes, time resolution for monitoring decreases. But at regions with high seismicity, it may be possible to monitor subsurface structures in sufficient time resolutions. Studying the 2011 Tohoku-Oki (Mw 9.0), Japan, earthquake for which velocity changes have been already reported by previous studies, I try to validate the method. KiK-net stations in northern Honshu are used in the analysis. For each moderate earthquake, normalized auto correlation functions of surface records are stacked with respect to time windows in S-wave coda. Aligning the stacked normalized auto correlation functions with time, I search for changes in arrival times of phases. The phases at lag times of less than 1s are studied because changes at shallow depths are focused. Based on the stretching method, temporal variations in the arrival times are measured at the stations. Clear phase delays are found to be associated with the mainshock and to gradually recover with time. Amounts of the phase delays are in the order of 10% on average with the maximum of about 50% at some stations. For validation, the deconvolution analysis using surface and subsurface records at the same stations are conducted. The results show that the phase delays from the deconvolution analysis are slightly smaller than those from the auto correlation analysis, which implies that the phases on the auto correlations are caused by larger velocity changes at shallower depths. The auto correlation analysis seems to have an accuracy of about several percents, which is much larger than methods using earthquake doublets and borehole array data. So this analysis might be applicable to detect larger changes. In spite of these disadvantages, this analysis is still attractive because it can be applied to many records on the surface in regions where no boreholes are available. Acknowledgements: Seismograms recorded by KiK-net managed by National Research Institute for Earth Science and Disaster Prevention (NIED) were used in this study. This study was partially supported by JST J-RAPID program and JSPS KAKENHI Grant Numbers 24540449 and 23540449.

How to detect fluctuating stripes in the high-temperature superconductors

NASA Astrophysics Data System (ADS)

Kivelson, S. A.; Bindloss, I. P.; Fradkin, E.; Oganesyan, V.; Tranquada, J. M.; Kapitulnik, A.; Howald, C.

2003-10-01

This article discusses fluctuating order in a quantum disordered phase proximate to a quantum critical point, with particular emphasis on fluctuating stripe order. Optimal strategies are derived for extracting information concerning such local order from experiments, with emphasis on neutron scattering and scanning tunneling microscopy. These ideas are tested by application to two model systems—an exactly solvable one-dimensional (1D) electron gas with an impurity, and a weakly interacting 2D electron gas. Experiments on the cuprate high-temperature superconductors which can be analyzed using these strategies are extensively reviewed. The authors adduce evidence that stripe correlations are widespread in the cuprates. They compare and contrast the advantages of two limiting perspectives on the high-temperature superconductor: weak coupling, in which correlation effects are treated as a perturbation on an underlying metallic (although renormalized) Fermi-liquid state, and strong coupling, in which the magnetism is associated with well-defined localized spins, and stripes are viewed as a form of micro phase separation. The authors present quantitative indicators that the latter view better accounts for the observed stripe phenomena in the cuprates.

Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells

NASA Technical Reports Server (NTRS)

Hu, Shaohua; Chen, Jianxin; Fabry, Ben; Numaguchi, Yasushi; Gouldstone, Andrew; Ingber, Donald E.; Fredberg, Jeffrey J.; Butler, James P.; Wang, Ning

2003-01-01

We describe a novel synchronous detection approach to map the transmission of mechanical stresses within the cytoplasm of an adherent cell. Using fluorescent protein-labeled mitochondria or cytoskeletal components as fiducial markers, we measured displacements and computed stresses in the cytoskeleton of a living cell plated on extracellular matrix molecules that arise in response to a small, external localized oscillatory load applied to transmembrane receptors on the apical cell surface. Induced synchronous displacements, stresses, and phase lags were found to be concentrated at sites quite remote from the localized load and were modulated by the preexisting tensile stress (prestress) in the cytoskeleton. Stresses applied at the apical surface also resulted in displacements of focal adhesion sites at the cell base. Cytoskeletal anisotropy was revealed by differential phase lags in X vs. Y directions. Displacements and stresses in the cytoskeleton of a cell plated on poly-L-lysine decayed quickly and were not concentrated at remote sites. These data indicate that mechanical forces are transferred across discrete cytoskeletal elements over long distances through the cytoplasm in the living adherent cell.

Doppler indices of gas phase formation in hypobaric environments: Time-intensity analysis

NASA Technical Reports Server (NTRS)

Powell, Michael R.

1991-01-01

A semi-quantitative method to analyze decompression data is described. It possesses the advantage that it allows a graded response to decompression rather than the dichotomous response generally employed. A generalized critical volume (C-V), or stoichiometric time-dependent equilibrium model is examined that relates the constant of the equation P sub i equals m P sub f plus b to variable tissue supersaturation and gas washout terms. The effects of the tissue ratio on gas phase formation indicate that a decreased ratio yields fewer individuals with Doppler detectable gas bubbles, but those individuals still present with Spencer Grade 3 or 4. This might indicate a local collapse of tissue saturation. The individuals with Grade 3 or 4 could be at risk for type 2 decompression sickness by transpulmonic arterialization. The primary regulator of the problems of decompression sickness is the reduction of local supersaturation, presumably governed by the presence and number of gas micronuclei. It is postulated that a reduction in these nuclei will favor a low incidence of decompression sickness in microgravity secondary to hypokinesia and adynamia.

Nanotechnology: a promising method for oral cancer detection and diagnosis.

PubMed

Chen, Xiao-Jie; Zhang, Xue-Qiong; Liu, Qi; Zhang, Jing; Zhou, Gang

2018-06-11

Oral cancer is a common and aggressive cancer with high morbidity, mortality, and recurrence rate globally. Early detection is of utmost importance for cancer prevention and disease management. Currently, tissue biopsy remains the gold standard for oral cancer diagnosis, but it is invasive, which may cause patient discomfort. The application of traditional noninvasive methods-such as vital staining, exfoliative cytology, and molecular imaging-is limited by insufficient sensitivity and specificity. Thus, there is an urgent need for exploring noninvasive, highly sensitive, and specific diagnostic techniques. Nano detection systems are known as new emerging noninvasive strategies that bring the detection sensitivity of biomarkers to nano-scale. Moreover, compared to current imaging contrast agents, nanoparticles are more biocompatible, easier to synthesize, and able to target specific surface molecules. Nanoparticles generate localized surface plasmon resonances at near-infrared wavelengths, providing higher image contrast and resolution. Therefore, using nano-based techniques can help clinicians to detect and better monitor diseases during different phases of oral malignancy. Here, we review the progress of nanotechnology-based methods in oral cancer detection and diagnosis.

Whisker Contact Detection of Rodents Based on Slow and Fast Mechanical Inputs

PubMed Central

Claverie, Laure N.; Boubenec, Yves; Debrégeas, Georges; Prevost, Alexis M.; Wandersman, Elie

2017-01-01

Rodents use their whiskers to locate nearby objects with an extreme precision. To perform such tasks, they need to detect whisker/object contacts with a high temporal accuracy. This contact detection is conveyed by classes of mechanoreceptors whose neural activity is sensitive to either slow or fast time varying mechanical stresses acting at the base of the whiskers. We developed a biomimetic approach to separate and characterize slow quasi-static and fast vibrational stress signals acting on a whisker base in realistic exploratory phases, using experiments on both real and artificial whiskers. Both slow and fast mechanical inputs are successfully captured using a mechanical model of the whisker. We present and discuss consequences of the whisking process in purely mechanical terms and hypothesize that free whisking in air sets a mechanical threshold for contact detection. The time resolution and robustness of the contact detection strategies based on either slow or fast stress signals are determined. Contact detection based on the vibrational signal is faster and more robust to exploratory conditions than the slow quasi-static component, although both slow/fast components allow localizing the object. PMID:28119582

Cluster-search based monitoring of local earthquakes in SeisComP3

NASA Astrophysics Data System (ADS)

Roessler, D.; Becker, J.; Ellguth, E.; Herrnkind, S.; Weber, B.; Henneberger, R.; Blanck, H.

2016-12-01

We present a new cluster-search based SeisComP3 module for locating local and regional earthquakes in real time. Real-time earthquake monitoring systems such as SeisComP3 provide the backbones for earthquake early warning (EEW), tsunami early warning (TEW) and the rapid assessment of natural and induced seismicity. For any earthquake monitoring system fast and accurate event locations are fundamental determining the reliability and the impact of further analysis. SeisComP3 in the OpenSource version includes a two-stage detector for picking P waves and a phase associator for locating earthquakes based on P-wave detections. scanloc is a more advanced earthquake location program developed by gempa GmbH with seamless integration into SeisComP3. scanloc performs advanced cluster search to discriminate earthquakes occurring closely in space and time and makes additional use of S-wave detections. It has proven to provide fast and accurate earthquake locations at local and regional distances where it outperforms the base SeisComP3 tools. We demonstrate the performance of scanloc for monitoring induced seismicity as well as local and regional earthquakes in different tectonic regimes including subduction, spreading and intra-plate regions. In particular we present examples and catalogs from real-time monitoring of earthquake in Northern Chile based on data from the IPOC network by GFZ German Research Centre for Geosciences for the recent years. Depending on epicentral distance and data transmission, earthquake locations are available within a few seconds after origin time when using scanloc. The association of automatic S-wave detections provides a better constraint on focal depth.

Facile detection of toxic ingredients in seafood using biologically enabled photonic crystal materials

NASA Astrophysics Data System (ADS)

Kong, Xianming; Squire, Kenneth; Wang, Alan X.

2018-02-01

Surface-enhanced Raman scattering (SERS) spectroscopy has attracted considerable attention recently as a powerful detection platform in biosensing because of the wealth of inherent information ascertained about the chemical and molecular composition of a sample. However, real-world samples are often composed of many components, which renders the detection of constitutes of mixed samples very challenging for SERS sensing. Accordingly, separation techniques are needed before SERS measurements. Thin layer chromatography (TLC) is a simple, fast and costeffective technique for analyte separation and can a play pivotal role for on-site sensing. However, combining TLC with SERS is only successful to detect a limited number of analytes that have large Raman scattering cross sections. As a kind of biogenic amine, histamine (2-(4-imidazolyl)-ethylamine) has a relationship with many health problems resulting from seafood consumption occurring worldwide. Diatomaceous earth consists of fossilized remains of diatoms, a type of hard-shelled algae. As a kind of natural photonic biosilica from geological deposits, it has a variety of unique properties including highly porous structure, excellent adsorption capacity, and low cost. In addition, the two dimensional periodic pores on diatomite earth with hierarchical nanoscale photonic crystal features can enhance the localized optical field. Herein, we fabricate TLC plates from diatomite as the stationary phase combining with SERS to separate and detect histamine from seafood samples. We have proved that the diatomite on the TLC plate not only functions as stationary phase, but also provides additional Raman enhancement, in which the detection limit of 2 ppm was achieved for pyrene in mixture.

Phased Array Ultrasonic Examination of Reactor Coolant System (Carbon Steel-to-CASS) Dissimilar Metal Weld Mockup Specimen

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crawford, S. L.; Cinson, A. D.; Diaz, A. A.

2015-11-23

In the summer of 2009, Pacific Northwest National Laboratory (PNNL) staff traveled to the Electric Power Research Institute (EPRI) NDE Center in Charlotte, North Carolina, to conduct phased-array ultrasonic testing on a large bore, reactor coolant pump nozzle-to-safe-end mockup. This mockup was fabricated by FlawTech, Inc. and the configuration originated from the Port St. Lucie nuclear power plant. These plants are Combustion Engineering-designed reactors. This mockup consists of a carbon steel elbow with stainless steel cladding joined to a cast austenitic stainless steel (CASS) safe-end with a dissimilar metal weld and is owned by Florida Power & Light. The objectivemore » of this study, and the data acquisition exercise held at the EPRI NDE Center, were focused on evaluating the capabilities of advanced, low-frequency phased-array ultrasonic testing (PA-UT) examination techniques for detection and characterization of implanted circumferential flaws and machined reflectors in a thick-section CASS dissimilar metal weld component. This work was limited to PA-UT assessments using 500 kHz and 800 kHz probes on circumferential flaws only, and evaluated detection and characterization of these flaws and machined reflectors from the CASS safe-end side only. All data were obtained using spatially encoded, manual scanning techniques. The effects of such factors as line-scan versus raster-scan examination approaches were evaluated, and PA-UT detection and characterization performance as a function of inspection frequency/wavelength, were also assessed. A comparative assessment of the data is provided, using length-sizing root-mean-square-error and position/localization results (flaw start/stop information) as the key criteria for flaw characterization performance. In addition, flaw signal-to-noise ratio was identified as the key criterion for detection performance.« less

Elimination of spiral waves in a locally connected chaotic neural network by a dynamic phase space constraint.

PubMed

Li, Yang; Oku, Makito; He, Guoguang; Aihara, Kazuyuki

2017-04-01

In this study, a method is proposed that eliminates spiral waves in a locally connected chaotic neural network (CNN) under some simplified conditions, using a dynamic phase space constraint (DPSC) as a control method. In this method, a control signal is constructed from the feedback internal states of the neurons to detect phase singularities based on their amplitude reduction, before modulating a threshold value to truncate the refractory internal states of the neurons and terminate the spirals. Simulations showed that with appropriate parameter settings, the network was directed from a spiral wave state into either a plane wave (PW) state or a synchronized oscillation (SO) state, where the control vanished automatically and left the original CNN model unaltered. Each type of state had a characteristic oscillation frequency, where spiral wave states had the highest, and the intra-control dynamics was dominated by low-frequency components, thereby indicating slow adjustments to the state variables. In addition, the PW-inducing and SO-inducing control processes were distinct, where the former generally had longer durations but smaller average proportions of affected neurons in the network. Furthermore, variations in the control parameter allowed partial selectivity of the control results, which were accompanied by modulation of the control processes. The results of this study broaden the applicability of DPSC to chaos control and they may also facilitate the utilization of locally connected CNNs in memory retrieval and the exploration of traveling wave dynamics in biological neural networks. Copyright © 2017 Elsevier Ltd. All rights reserved.

The Origins of [C ii] Emission in Local Star-forming Galaxies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Croxall, K. V.; Smith, J. D.; Pellegrini, E.

The [C ii] 158 μ m fine-structure line is the brightest emission line observed in local star-forming galaxies. As a major coolant of the gas-phase interstellar medium, [C ii] balances the heating, including that due to far-ultraviolet photons, which heat the gas via the photoelectric effect. However, the origin of [C ii] emission remains unclear because C{sup +} can be found in multiple phases of the interstellar medium. Here we measure the fractions of [C ii] emission originating in the ionized and neutral gas phases of a sample of nearby galaxies. We use the [N ii] 205 μ m fine-structuremore » line to trace the ionized medium, thereby eliminating the strong density dependence that exists in the ratio of [C ii]/[N ii] 122 μ m. Using the FIR [C ii] and [N ii] emission detected by the KINGFISH (Key Insights on Nearby Galaxies: a Far- Infrared Survey with Herschel ) and Beyond the Peak Herschel programs, we show that 60%–80% of [C ii] emission originates from neutral gas. We find that the fraction of [C ii] originating in the neutral medium has a weak dependence on dust temperature and the surface density of star formation, and has a stronger dependence on the gas-phase metallicity. In metal-rich environments, the relatively cooler ionized gas makes substantially larger contributions to total [C ii] emission than at low abundance, contrary to prior expectations. Approximate calibrations of this metallicity trend are provided.« less

Theoretical foundations of the sound analog membrane potential that underlies coincidence detection in the barn owl

PubMed Central

Ashida, Go; Funabiki, Kazuo; Carr, Catherine E.

2013-01-01

A wide variety of neurons encode temporal information via phase-locked spikes. In the avian auditory brainstem, neurons in the cochlear nucleus magnocellularis (NM) send phase-locked synaptic inputs to coincidence detector neurons in the nucleus laminaris (NL) that mediate sound localization. Previous modeling studies suggested that converging phase-locked synaptic inputs may give rise to a periodic oscillation in the membrane potential of their target neuron. Recent physiological recordings in vivo revealed that owl NL neurons changed their spike rates almost linearly with the amplitude of this oscillatory potential. The oscillatory potential was termed the sound analog potential, because of its resemblance to the waveform of the stimulus tone. The amplitude of the sound analog potential recorded in NL varied systematically with the interaural time difference (ITD), which is one of the most important cues for sound localization. In order to investigate the mechanisms underlying ITD computation in the NM-NL circuit, we provide detailed theoretical descriptions of how phase-locked inputs form oscillating membrane potentials. We derive analytical expressions that relate presynaptic, synaptic, and postsynaptic factors to the signal and noise components of the oscillation in both the synaptic conductance and the membrane potential. Numerical simulations demonstrate the validity of the theoretical formulations for the entire frequency ranges tested (1–8 kHz) and potential effects of higher harmonics on NL neurons with low best frequencies (<2 kHz). PMID:24265616

Quantitative tracking of tumor cells in phase-contrast microscopy exploiting halo artifact pattern

NASA Astrophysics Data System (ADS)

Kang, Mi-Sun; Song, Soo-Min; Lee, Hana; Kim, Myoung-Hee

2012-03-01

Tumor cell morphology is closely related to its invasiveness characteristics and migratory behaviors. An invasive tumor cell has a highly irregular shape, whereas a spherical cell is non-metastatic. Thus, quantitative analysis of cell features is crucial to determine tumor malignancy or to test the efficacy of anticancer treatment. We use phase-contrast microscopy to analyze single cell morphology and to monitor its change because it enables observation of long-term activity of living cells without photobleaching and phototoxicity, which is common in other fluorescence-labeled microscopy. Despite this advantage, there are image-level drawbacks to phase-contrast microscopy, such as local light effect and contrast interference ring, among others. Thus, we first applied a local filter to compensate for non-uniform illumination. Then, we used intensity distribution information to detect the cell boundary. In phase-contrast microscopy images, the cell normally appears as a dark region surrounded by a bright halo. As the halo artifact around the cell body is minimal and has an asymmetric diffusion pattern, we calculated the cross-sectional plane that intersected the center of each cell and was orthogonal to the first principal axis. Then, we extracted the dark cell region by level set. However, a dense population of cultured cells still rendered single-cell analysis difficult. Finally, we measured roundness and size to classify tumor cells into malignant and benign groups. We validated segmentation accuracy by comparing our findings with manually obtained results.

Orbital apocenter is not a sufficient condition for HST/STIS detection of Europa's water vapor aurora.

PubMed

Roth, Lorenz; Retherford, Kurt D; Saur, Joachim; Strobel, Darrell F; Feldman, Paul D; McGrath, Melissa A; Nimmo, Francis

2014-12-02

We report far-ultraviolet observations of Jupiter's moon Europa taken by Space Telescope Imaging Spectrograph (STIS) of the Hubble Space Telescope (HST) in January and February 2014 to test the hypothesis that the discovery of a water vapor aurora in December 2012 by local hydrogen (H) and oxygen (O) emissions with the STIS originated from plume activity possibly correlated with Europa's distance from Jupiter through tidal stress variations. The 2014 observations were scheduled with Europa near the apocenter similar to the orbital position of its previous detection. Tensile stresses on south polar fractures are expected to be highest in this orbital phase, potentially maximizing the probability for plume activity. No local H and O emissions were detected in the new STIS images. In the south polar region where the emission surpluses were observed in 2012, the brightnesses are sufficiently low in the 2014 images to be consistent with any H2O abundance from (0-5)×10(15) cm(-2). Large high-latitude plumes should have been detectable by the STIS, independent of the observing conditions and geometry. Because electron excitation of water vapor remains the only viable explanation for the 2012 detection, the new observations indicate that although the same orbital position of Europa for plume activity may be a necessary condition, it is not a sufficient condition. However, the December 2012 detection of coincident HI Lyman-α and OI 1304-Å emission surpluses in an ∼200-km high region well separated above Europa's limb is a firm result and not invalidated by our 2014 STIS observations.

Orbital apocenter is not a sufficient condition for HST/STIS detection of Europa's water vapor aurora

NASA Astrophysics Data System (ADS)

Roth, Lorenz; Retherford, Kurt D.; Saur, Joachim; Strobel, Darrell F.; Feldman, Paul D.; McGrath, Melissa A.; Nimmo, Francis

2014-12-01

We report far-ultraviolet observations of Jupiter's moon Europa taken by Space Telescope Imaging Spectrograph (STIS) of the Hubble Space Telescope (HST) in January and February 2014 to test the hypothesis that the discovery of a water vapor aurora in December 2012 by local hydrogen (H) and oxygen (O) emissions with the STIS originated from plume activity possibly correlated with Europa's distance from Jupiter through tidal stress variations. The 2014 observations were scheduled with Europa near the apocenter similar to the orbital position of its previous detection. Tensile stresses on south polar fractures are expected to be highest in this orbital phase, potentially maximizing the probability for plume activity. No local H and O emissions were detected in the new STIS images. In the south polar region where the emission surpluses were observed in 2012, the brightnesses are sufficiently low in the 2014 images to be consistent with any H2O abundance from (0-5)×1015 cm-2. Large high-latitude plumes should have been detectable by the STIS, independent of the observing conditions and geometry. Because electron excitation of water vapor remains the only viable explanation for the 2012 detection, the new observations indicate that although the same orbital position of Europa for plume activity may be a necessary condition, it is not a sufficient condition. However, the December 2012 detection of coincident HI Lyman-α and OI 1304-Å emission surpluses in an ∼200-km high region well separated above Europa's limb is a firm result and not invalidated by our 2014 STIS observations.

Dichotic beats of mistuned consonances.

PubMed

Feeney, M P

1997-10-01

The beats of mistuned consonances (BMCs) result from the presentation of two sinusoids at frequencies slightly mistuned from a ratio of small integers. Several studies have suggested that the source of dichotic BMCs is an interaction within a binaural critical band. In one case the mechanism has been explained as an aural harmonic of the low-frequency tone (f1) creating binaural beats with the high-frequency tone (f2). The other explanation involves a binaural cross correlation between the excitation pattern of f1 and the contralateral f2--occurring within the binaural critical band centered at f2. This study examined the detection of dichotic BMCs for the octave and fifth. In one experiment with the octave, narrow-band noise centered at f2 was presented to one ear along with f1. The other ear was presented with f2. The noise was used to prevent interactions in the binaural critical band centered at f2. Dichotic BMCs were still detected under these conditions, suggesting that binaural interaction within a critical band does not explain the effect. Localization effects were also observed under this masking condition for phase reversals of tuned dichotic octave stimuli. These findings suggest a new theory of dichotic BMCs as a between-channel phase effect. The modified weighted-image model of localization [Stern and Trahiotis, in Auditory Physiology and Perception, edited by Y. Cazals, L. Demany, and K. Horner (Pergamon, Oxford, 1992), pp. 547-554] was used to provide an explanation of the between-channel mechanism.

Effects of loss on the phase sensitivity with parity detection in an SU(1,1) interferometer

NASA Astrophysics Data System (ADS)

Li, Dong; Yuan, Chun-Hua; Yao, Yao; Jiang, Wei; Li, Mo; Zhang, Weiping

2018-05-01

We theoretically study the effects of loss on the phase sensitivity of an SU(1,1) interferometer with parity detection with various input states. We show that although the sensitivity of phase estimation decreases in the presence of loss, it can still beat the shot-noise limit with small loss. To examine the performance of parity detection, the comparison is performed among homodyne detection, intensity detection, and parity detection. Compared with homodyne detection and intensity detection, parity detection has a slight better optimal phase sensitivity in the absence of loss, but has a worse optimal phase sensitivity with a significant amount of loss with one-coherent state or coherent $\\otimes$ squeezed state input.

Development of a High-Resolution, Single-Photon X-Ray Detector

NASA Technical Reports Server (NTRS)

Seidel, George M.

1996-01-01

Research on the development of a low-temperature, magnetic bolometer for x-ray detection is reported. The principal accomplishments during the first phase of this research are as follows. (1) We have constructed SQUID magnetometers and detected both 122 keV and 6 keV x-rays in relatively larger metallic samples with high quantum efficiency. (2) The magnetic properties of a metal sample with localized paramagnetic spins have been measured and found to agree with theoretical expectations. (3) The size of the magnetic response of the sample to x-rays is in agreement with predictions based on the properties of the sample and sensitivity of the magnetometer, supporting the prediction that a resolution of 1 eV at 10 keV should be achievable.

LARGE-SCALE CONTRACTION AND SUBSEQUENT DISRUPTION OF CORONAL LOOPS DURING VARIOUS PHASES OF THE M6.2 FLARE ASSOCIATED WITH THE CONFINED FLUX ROPE ERUPTION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kushwaha, Upendra; Joshi, Bhuwan; Moon, Yong-Jae

We investigate evolutionary phases of an M6.2 flare and the associated confined eruption of a prominence. The pre-flare phase exhibits spectacular large-scale contraction of overlying extreme ultraviolet (EUV) coronal loops during which the loop system was subjected to an altitude decrease of ∼20 Mm (40% of the initial height) for an extended span of ∼30 minutes. This contraction phase is accompanied by sequential EUV brightenings associated with hard X-ray (HXR; up to 25 keV) and microwave (MW) sources from low-lying loops in the core region which together with X-ray spectra indicate strong localized heating in the source region before themore » filament activation. With the onset of the flare’s impulsive phase, we detect HXR and MW sources that exhibit intricate temporal and spatial evolution in relation to the fast rise of the prominence. Following the flare maximum, the filament eruption slowed down and subsequently became confined within the large overlying active region loops. During the confinement process of the erupting prominence, we detect MW emission from the extended coronal region with multiple emission centroids, which likely represent emission from hot blobs of plasma formed after the collapse of the expanding flux rope and entailing prominence material. RHESSI spectroscopy reveals high plasma temperature (∼30 MK) and substantial non-thermal characteristics (δ ∼ 5) during the impulsive phase of the flare. The time evolution of thermal energy exhibits a good correspondence with the variations in cumulative non-thermal energy, which suggests that the energy of accelerated particles is efficiently converted to hot flare plasma, implying an effective validation of the Neupert effect.« less

Hypogeal geological survey in the "Grotta del Re Tiberio" natural cave (Apennines, Italy): a valid tool for reconstructing the structural setting

NASA Astrophysics Data System (ADS)

Ghiselli, Alice; Merazzi, Marzio; Strini, Andrea; Margutti, Roberto; Mercuriali, Michele

2011-06-01

As karst systems are natural windows to the underground, speleology, combined with geological surveys, can be useful tools for helping understand the geological evolution of karst areas. In order to enhance the reconstruction of the structural setting in a gypsum karst area (Vena del Gesso, Romagna Apennines), a detailed analysis has been carried out on hypogeal data. Structural features (faults, fractures, tectonic foliations, bedding) have been mapped in the "Grotta del Re Tiberio" cave, in the nearby gypsum quarry tunnels and open pit benches. Five fracture systems and six fault systems have been identified. The fault systems have been further analyzed through stereographic projections and geometric-kinematic evaluations in order to reconstruct the relative chronology of these structures. This analysis led to the detection of two deformation phases. The results permitted linking of the hypogeal data with the surface data both at a local and regional scale. At the local scale, fracture data collected in the underground have been compared with previous authors' surface data coming from the quarry area. The two data sets show a very good correspondence, as every underground fracture system matches with one of the surface fracture system. Moreover, in the cave, a larger number of fractures belonging to each system could be mapped. At the regional scale, the two deformation phases detected can be integrated in the structural setting of the study area, thereby enhancing the tectonic interpretation of the area ( e.g., structures belonging to a new deformation phase, not reported before, have been identified underground). The structural detailed hypogeal survey has, thus, provided very useful data, both by integrating the existing information and revealing new data not detected at the surface. In particular, some small structures ( e.g., displacement markers and short fractures) are better preserved in the hypogeal environment than on the surface where the outcropping gypsum is more exposed to dissolution and recrystallization. The hypogeal geological survey, therefore, can be considered a powerful tool for integrating the surface and log data in order to enhance the reconstruction of the deformational history and to get a three-dimensional model of the bedrock in karst areas.

Surface Wave Propagation on a Laterally Heterogeneous Earth

NASA Astrophysics Data System (ADS)

Tromp, Jeroen

1992-01-01

Love and Rayleigh waves propagating on the surface of the Earth exhibit path, phase and amplitude anomalies as a result of the lateral heterogeneity of the mantle. In the JWKB approximation, these anomalies can be determined by tracing surface wave trajectories, and calculating phase and amplitude anomalies along them. A time- or frequency -domain JWKB analysis yields local eigenfunctions, local dispersion relations, and conservation laws for the surface wave energy. The local dispersion relations determine the surface wave trajectories, and the energy equations determine the surface wave amplitudes. On an anisotrophic Earth model the local dispersion relation and the local vertical eigenfunctions depend explicitly on the direction of the local wavevector. Apart from the usual dynamical phase, which is the integral of the local wavevector along a raypath, there is an additional variation is phase. This additional phase, which is an analogue of the Berry phase in adiabatic quantum mechanics, vanishes in a waveguide with a local vertical two-fold symmetry axis or a local horizontal mirror plane. JWKB theory breaks down in the vicinity of caustics, where neighboring rays merge and the surface wave amplitude diverges. Based upon a potential representation of the surface wave field, a uniformly valid Maslov theory can be obtained. Surface wave trajectories are determined by a system of four ordinary differential equations which define a three-dimensional manifold in four-dimensional phase space (theta,phi,k_theta,k _phi), where theta is colatitude, phi is longitude, and k_theta and k _phi are the covariant components of the wavevector. There are no caustics in phase space; it is only when the rays in phase space are projected onto configuration space (theta,phi), the mixed spaces (k_theta,phi ) and (theta,k_phi), or onto momentum space (k_theta,k _phi), that caustics occur. The essential strategy is to employ a mixed or momentum space representation of the wavefield in the vicinity of a configuration space caustic.

Designing and Implementing a Retrospective Earthquake Detection Framework at the U.S. Geological Survey National Earthquake Information Center

NASA Astrophysics Data System (ADS)

Patton, J.; Yeck, W.; Benz, H.

2017-12-01

The U.S. Geological Survey National Earthquake Information Center (USGS NEIC) is implementing and integrating new signal detection methods such as subspace correlation, continuous beamforming, multi-band picking and automatic phase identification into near-real-time monitoring operations. Leveraging the additional information from these techniques help the NEIC utilize a large and varied network on local to global scales. The NEIC is developing an ordered, rapid, robust, and decentralized framework for distributing seismic detection data as well as a set of formalized formatting standards. These frameworks and standards enable the NEIC to implement a seismic event detection framework that supports basic tasks, including automatic arrival time picking, social media based event detections, and automatic association of different seismic detection data into seismic earthquake events. In addition, this framework enables retrospective detection processing such as automated S-wave arrival time picking given a detected event, discrimination and classification of detected events by type, back-azimuth and slowness calculations, and ensuring aftershock and induced sequence detection completeness. These processes and infrastructure improve the NEIC's capabilities, accuracy, and speed of response. In addition, this same infrastructure provides an improved and convenient structure to support access to automatic detection data for both research and algorithmic development.

Sensitivity Enhancement of an Inductively Coupled Local Detector Using a HEMT-Based Current Amplifier.

PubMed

Qian, Chunqi; Duan, Qi; Dodd, Steve; Koretsky, Alan; Murphy-Boesch, Joe

2016-06-01

To improve the signal transmission efficiency and sensitivity of a local detection coil that is weakly inductively coupled to a larger receive coil. The resonant detection coil is connected in parallel with the gate of a high electron mobility transistor (HEMT) transistor without impedance matching. When the drain of the transistor is capacitively shunted to ground, current amplification occurs in the resonator by feedback that transforms a capacitive impedance on the transistor's source to a negative resistance on its gate. High resolution images were obtained from a mouse brain using a small, 11 mm diameter surface coil that was inductively coupled to a commercial, phased array chest coil. Although the power consumption of the amplifier was only 88 μW, 14 dB gain was obtained with excellent noise performance. An integrated current amplifier based on a HEMT can enhance the sensitivity of inductively coupled local detectors when weakly coupled. This amplifier enables efficient signal transmission between customized user coils and commercial clinical coils, without the need for a specialized signal interface. Magn Reson Med 75:2573-2578, 2016. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. Published 2015 This article is a U.S. Government work and is in the public domain in the USA.

The cdk7-cyclin H-MAT1 complex associated with TFIIH is localized in coiled bodies.

PubMed Central

Jordan, P; Cunha, C; Carmo-Fonseca, M

1997-01-01

TFIIH is a general transcription factor for RNA polymerase II that in addition is involved in DNA excision repair. TFIIH is composed of eight or nine subunits and we show that at least four of them, namely cdk7, cyclin H, MAT1, and p62 are localized in the coiled body, a distinct subnuclear structure that is transcription dependent and highly enriched in small nuclear ribonucleoproteins. Although coiled bodies do not correspond to sites of transcription, in vivo incorporation of bromo-UTP shows that they are surrounded by transcription foci. Immunofluorescence analysis using antibodies directed against the essential repair factors proliferating cell nuclear antigen and XPG did not reveal labeling of the coiled body in either untreated cells or cells irradiated with UV light, arguing that coiled bodies are probably not involved in DNA repair mechanisms. The localization of cyclin H in the coiled body was predominantly detected during the G1 and S-phases of the cell cycle, whereas in G2 coiled bodies were very small or not detected. Finally, both cyclin H and cdk7 did not colocalize with P80 coilin after disruption of the coiled body, indicating that these proteins are specifically targeted to the small nuclear ribonucleoprotein-containing domain. Images PMID:9243502

Detection, Localization and Quantification of Impact Events on a Stiffened Composite Panel with Embedded Fiber Bragg Grating Sensor Networks

PubMed Central

Lamberti, Alfredo; Luyckx, Geert; Van Paepegem, Wim; Rezayat, Ali; Vanlanduit, Steve

2017-01-01

Nowadays, it is possible to manufacture smart composite materials with embedded fiber optic sensors. These sensors can be exploited during the composites’ operating life to identify occurring damages such as delaminations. For composite materials adopted in the aviation and wind energy sector, delaminations are most often caused by impacts with external objects. The detection, localization and quantification of such impacts are therefore crucial for the prevention of catastrophic events. In this paper, we demonstrate the feasibility to perform impact identification in smart composite structures with embedded fiber optic sensors. For our analyses, we manufactured a carbon fiber reinforced plate in which we embedded a distributed network of fiber Bragg grating (FBG) sensors. We impacted the plate with a modal hammer and we identified the impacts by processing the FBG data with an improved fast phase correlation (FPC) algorithm in combination with a variable selective least squares (VS-LS) inverse solver approach. A total of 164 impacts distributed on 41 possible impact locations were analyzed. We compared our methodology with the traditional P-Inv based approach. In terms of impact localization, our methodology performed better in 70.7% of the cases. An improvement on the impact time domain reconstruction was achieved in 95.1% of the cases. PMID:28368319

Detection, Localization and Quantification of Impact Events on a Stiffened Composite Panel with Embedded Fiber Bragg Grating Sensor Networks.

PubMed

Lamberti, Alfredo; Luyckx, Geert; Van Paepegem, Wim; Rezayat, Ali; Vanlanduit, Steve

2017-04-01

Nowadays, it is possible to manufacture smart composite materials with embedded fiber optic sensors. These sensors can be exploited during the composites' operating life to identify occurring damages such as delaminations. For composite materials adopted in the aviation and wind energy sector, delaminations are most often caused by impacts with external objects. The detection, localization and quantification of such impacts are therefore crucial for the prevention of catastrophic events. In this paper, we demonstrate the feasibility to perform impact identification in smart composite structures with embedded fiber optic sensors. For our analyses, we manufactured a carbon fiber reinforced plate in which we embedded a distributed network of fiber Bragg grating (FBG) sensors. We impacted the plate with a modal hammer and we identified the impacts by processing the FBG data with an improved fast phase correlation (FPC) algorithm in combination with a variable selective least squares (VS-LS) inverse solver approach. A total of 164 impacts distributed on 41 possible impact locations were analyzed. We compared our methodology with the traditional P-Inv based approach. In terms of impact localization, our methodology performed better in 70.7% of the cases. An improvement on the impact time domain reconstruction was achieved in 95 . 1 % of the cases.

On precise phase difference measurement approach using border stability of detection resolution.

PubMed

Bai, Lina; Su, Xin; Zhou, Wei; Ou, Xiaojuan

2015-01-01

For the precise phase difference measurement, this paper develops an improved dual phase coincidence detection method. The measurement resolution of the digital phase coincidence detection circuits is always limited, for example, only at the nanosecond level. This paper reveals a new way to improve the phase difference measurement precision by using the border stability of the circuit detection fuzzy areas. When a common oscillator signal is used to detect the phase coincidence with the two comparison signals, there will be two detection fuzzy areas for the reason of finite detection resolution surrounding the strict phase coincidence. Border stability of fuzzy areas and the fluctuation difference of the two fuzzy areas can be even finer than the picoseconds level. It is shown that the system resolution obtained only depends on the stability of the circuit measurement resolution which is much better than the measurement device resolution itself.

Acousto-optical assessment of skin viscoelasticity

NASA Astrophysics Data System (ADS)

Kirkpatrick, Sean J.; Duncan, Donald D.

2003-07-01

A multiphysics approach, combining acoustics, optics, and mechanics can be used to detect regions of skin with distinct mechanical behavior that may indicate a pathology, such as a cancerous skin lesion. Herein, an acousto-optical approach to evaluating the viscoelastic behavior of superficial skin layers will be presented. The method relies upon inducing low frequency guided surface waves in the skin and detecting these waves by monitoring the shift in the backscattered laser speckle pattern created by illuminating a small region of the skin with coherent light. Artificial lesions in the form of chemical cross-linking and chemical softening were induced in superficial porcine skin layers and detected based upon variations in local mechanical behavior. The lesions affect not only the time-of-flight of the guided surface waves, but also change the relative phase of the acoustic waves as determined optically. The method may be applicable in the study and diagnosis of superficial skin lesions.

Optical assessment of tissue mechanics: acousto-optical elastography of skin

NASA Astrophysics Data System (ADS)

Kirkpatrick, Sean J.

2003-10-01

A multiphysics approach, combining acoustics, optics, and mechanics can be used to detect regions of skin with distinct mechanical behavior that may indicate a pathology, such as a cancerous skin lesion. Herein, an acousto - optical approach to evaluating the viscoelastic behavior of superficial skin layers will be presented. The method relies upon inducing low frequency guided surface waves in the skin and detecting these waves by monitoring the shift in the backscattered laser speckle pattern created by illuminating a small region of the skin with coherent light. Artificial lesions in the form of chemical cross-linking and chemical softening were induced in superficial porcine skin layers and detected based upon variations in local mechanical behavior. The lesions affect not only the time-of-flight of the guided surface waves, but also change the relative phase of the acoustic waves as determined optically. The method may be applicable in the study and diagnosis of superficial skin lesions.

Characterization of a remote optical element with bi-photons

NASA Astrophysics Data System (ADS)

Puhlmann, D.; Henkel, C.; Heuer, A.; Pieplow, G.; Menzel, R.

2016-02-01

We present a simple setup that exploits the interference of entangled photon pairs. ‘Signal’ photons are sent through a Mach-Zehnder-like interferometer, while ‘idlers’ are detected in a variable polarization state. Two-photon interference (in coincidence detection) is observed with very high contrast and for significant time delays between signal and idler detection events. This is explained by quantum erasure of the polarization tag and a delayed choice protocol involving a non-local virtual polarizer. The phase of the two-photon fringes is scanned by varying the path length in the signal beam or by rotating a birefringent crystal in the idler beam. We exploit this to characterize one beam splitter of the signal photon interferometer (reflection and transmission amplitudes including losses), using only information about coincidences and control parameters in the idler path. This is possible because our bi-photon state saturates the Greenberger-Yelin-Englert inequality between contrast and predictability.

Suppression of optical beat interference-noise in orthogonal frequency division multiple access-passive optical network link using self-homodyne balanced detection

NASA Astrophysics Data System (ADS)

Won, Yong-Yuk; Jung, Sang-Min; Han, Sang-Kook

2014-08-01

A new technique, which reduces optical beat interference (OBI) noise in orthogonal frequency division multiple access-passive optical network (OFDMA-PON) links, is proposed. A self-homodyne balanced detection, which uses a single laser for the optical line terminal (OLT) as well as for the optical network unit (ONU), reduces OBI noise and also improves the signal to noise ratio (SNR) of the discrete multi-tone (DMT) signal. The proposed scheme is verified by transmitting quadrature phase shift keying (QPSK)-modulated DMT signal over a 20-km single mode fiber. The optical signal to noise ratio (OSNR), that is required for BER of 10-5, is reduced by 2 dB in the balanced detection compared with a single channel due to the cancellation of OBI noise in conjunction with the local laser.

Detection and quantification of solute clusters in a nanostructured ferritic alloy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, Michael K.; Larson, David J.; Reinhard, D. A.

2014-12-26

A series of simulated atom probe datasets were examined with a friends-of-friends method to establish the detection efficiency required to resolve solute clusters in the ferrite phase of a 14YWT nanostructured ferritic alloy. The size and number densities of solute clusters in the ferrite of the as-milled mechanically-alloyed condition and the stir zone of a friction stir weld were estimated with a prototype high-detection-efficiency (~80%) local electrode atom probe. High number densities, 1.8 × 10 24 m –3 and 1.2 × 10 24 m –3, respectively of solute clusters containing between 2 and 9 solute atoms of Ti, Y andmore » O and were detected for these two conditions. Furthermore, these results support first principle calculations that predicted that vacancies stabilize these Ti–Y–O– clusters, which retard diffusion and contribute to the excellent high temperature stability of the microstructure and radiation tolerance of nanostructured ferritic alloys.« less

Genome-Wide Structural Variation Detection by Genome Mapping on Nanochannel Arrays.

PubMed

Mak, Angel C Y; Lai, Yvonne Y Y; Lam, Ernest T; Kwok, Tsz-Piu; Leung, Alden K Y; Poon, Annie; Mostovoy, Yulia; Hastie, Alex R; Stedman, William; Anantharaman, Thomas; Andrews, Warren; Zhou, Xiang; Pang, Andy W C; Dai, Heng; Chu, Catherine; Lin, Chin; Wu, Jacob J K; Li, Catherine M L; Li, Jing-Woei; Yim, Aldrin K Y; Chan, Saki; Sibert, Justin; Džakula, Željko; Cao, Han; Yiu, Siu-Ming; Chan, Ting-Fung; Yip, Kevin Y; Xiao, Ming; Kwok, Pui-Yan

2016-01-01

Comprehensive whole-genome structural variation detection is challenging with current approaches. With diploid cells as DNA source and the presence of numerous repetitive elements, short-read DNA sequencing cannot be used to detect structural variation efficiently. In this report, we show that genome mapping with long, fluorescently labeled DNA molecules imaged on nanochannel arrays can be used for whole-genome structural variation detection without sequencing. While whole-genome haplotyping is not achieved, local phasing (across >150-kb regions) is routine, as molecules from the parental chromosomes are examined separately. In one experiment, we generated genome maps from a trio from the 1000 Genomes Project, compared the maps against that derived from the reference human genome, and identified structural variations that are >5 kb in size. We find that these individuals have many more structural variants than those published, including some with the potential of disrupting gene function or regulation. Copyright © 2016 by the Genetics Society of America.

Phase-Locked Responses to Speech in Human Auditory Cortex are Enhanced During Comprehension

PubMed Central

Peelle, Jonathan E.; Gross, Joachim; Davis, Matthew H.

2013-01-01

A growing body of evidence shows that ongoing oscillations in auditory cortex modulate their phase to match the rhythm of temporally regular acoustic stimuli, increasing sensitivity to relevant environmental cues and improving detection accuracy. In the current study, we test the hypothesis that nonsensory information provided by linguistic content enhances phase-locked responses to intelligible speech in the human brain. Sixteen adults listened to meaningful sentences while we recorded neural activity using magnetoencephalography. Stimuli were processed using a noise-vocoding technique to vary intelligibility while keeping the temporal acoustic envelope consistent. We show that the acoustic envelopes of sentences contain most power between 4 and 7 Hz and that it is in this frequency band that phase locking between neural activity and envelopes is strongest. Bilateral oscillatory neural activity phase-locked to unintelligible speech, but this cerebro-acoustic phase locking was enhanced when speech was intelligible. This enhanced phase locking was left lateralized and localized to left temporal cortex. Together, our results demonstrate that entrainment to connected speech does not only depend on acoustic characteristics, but is also affected by listeners’ ability to extract linguistic information. This suggests a biological framework for speech comprehension in which acoustic and linguistic cues reciprocally aid in stimulus prediction. PMID:22610394

Phase-locked responses to speech in human auditory cortex are enhanced during comprehension.

PubMed

Peelle, Jonathan E; Gross, Joachim; Davis, Matthew H

2013-06-01

A growing body of evidence shows that ongoing oscillations in auditory cortex modulate their phase to match the rhythm of temporally regular acoustic stimuli, increasing sensitivity to relevant environmental cues and improving detection accuracy. In the current study, we test the hypothesis that nonsensory information provided by linguistic content enhances phase-locked responses to intelligible speech in the human brain. Sixteen adults listened to meaningful sentences while we recorded neural activity using magnetoencephalography. Stimuli were processed using a noise-vocoding technique to vary intelligibility while keeping the temporal acoustic envelope consistent. We show that the acoustic envelopes of sentences contain most power between 4 and 7 Hz and that it is in this frequency band that phase locking between neural activity and envelopes is strongest. Bilateral oscillatory neural activity phase-locked to unintelligible speech, but this cerebro-acoustic phase locking was enhanced when speech was intelligible. This enhanced phase locking was left lateralized and localized to left temporal cortex. Together, our results demonstrate that entrainment to connected speech does not only depend on acoustic characteristics, but is also affected by listeners' ability to extract linguistic information. This suggests a biological framework for speech comprehension in which acoustic and linguistic cues reciprocally aid in stimulus prediction.

Investigation of local evaporation flux and vapor-phase pressure at an evaporative droplet interface.

PubMed

Duan, Fei; Ward, C A

2009-07-07

In the steady-state experiments of water droplet evaporation, when the throat was heating at a stainless steel conical funnel, the interfacial liquid temperature was found to increase parabolically from the center line to the rim of the funnel with the global vapor-phase pressure at around 600 Pa. The energy conservation analysis at the interface indicates that the energy required for evaporation is maintained by thermal conduction to the interface from the liquid and vapor phases, thermocapillary convection at interface, and the viscous dissipation globally and locally. The local evaporation flux increases from the center line to the periphery as a result of multiple effects of energy transport at the interface. The local vapor-phase pressure predicted from statistical rate theory (SRT) is also found to increase monotonically toward the interface edge from the center line. However, the average value of the local vapor-phase pressures is in agreement with the measured global vapor-phase pressure within the measured error bar.

Various oscillation patterns in phase models with locally attractive and globally repulsive couplings.

PubMed

Sato, Katsuhiko; Shima, Shin-ichiro

2015-10-01

We investigate a phase model that includes both locally attractive and globally repulsive coupling in one dimension. This model exhibits nontrivial spatiotemporal patterns that have not been observed in systems that contain only local or global coupling. Depending on the relative strengths of the local and global coupling and on the form of global coupling, the system can show a spatially uniform state (in-phase synchronization), a monotonically increasing state (traveling wave), and three types of oscillations of relative phase difference. One of the oscillations of relative phase difference has the characteristic of being locally unstable but globally attractive. That is, any small perturbation to the periodic orbit in phase space destroys its periodic motion, but after a long time the system returns to the original periodic orbit. This behavior is closely related to the emergence of saddle two-cluster states for global coupling only, which are connected to each other by attractive heteroclinic orbits. The mechanism of occurrence of this type of oscillation is discussed.

Atmospheric PCB concentrations at Terra Nova Bay, Antarctica.

PubMed

Gambaro, Andrea; Manodori, Laura; Zangrando, Roberta; Cincinelli, Alessandra; Capodaglio, Gabriele; Cescon, Paolo

2005-12-15

Concentrations of gas-phase polychlorobiphenyls (PCBs) were studied over an austral summer at a site in Terra Nova Bay, Antarctica. Gas-phase concentrations of individual PCB congeners in the atmosphere of Terra Nova Bay ranged from below the detection limit to 0.25 pg m(-3), with a mean concentration of sigmaPCB of 1.06 pg m(-3). The PCB profile was dominated by lower-chlorinated PCB congeners; in fact >78% of the total PCB content was due to congeners with 1-4 chlorine atoms and only about 10% with 5-7 chlorines, whereas higher-chlorinated PCB congeners were below detection limits. The mean sigmaPCB concentration obtained in this study were lower than those reported in previous Antarctic studies. Temporal concentration profiles of sigmaPCB do not correspond to seasonal temperature changes. In consideration of the low PCB concentrations observed, the studies with the wind roses, the regression between In P(PCB) and T(-1), and the distribution of congeners, we can hypothesize that PCB local source contributions are not very important, whereas long-distance transport is the prevalent factor bringing PCBs to Terra Nova Bay.

Ultrathin-shell boron nitride hollow spheres as sorbent for dispersive solid-phase extraction of polychlorinated biphenyls from environmental water samples.

PubMed

Fu, Meizhen; Xing, Hanzhu; Chen, Xiangfeng; Chen, Fan; Wu, Chi-Man Lawrence; Zhao, Rusong; Cheng, Chuange

2014-11-21

Boron nitride hollow spheres with ultrathin-shells were synthesized and used as sorbents for dispersive solid-phase extraction of aromatic pollutants at trace levels from environmental water samples. Polychlorinated biphenyls (PCBs) were selected as target compounds. Sample quantification and detection were performed by gas chromatography-tandem mass spectrometry. Extraction parameters influencing the extraction efficiency were optimized through response surface methodology using the Box-Behnken design. The proposed method achieved good linearity within the concentration range of 0.15-250 ng L(-1) PCBs, low limits of detection (0.04-0.09 ng L(-1), S/N=3:1), good repeatability of the extractions (relative standard deviation, <12%, n=6), and satisfactory recoveries between 84.9% and 101.0% under optimal conditions. Real environmental samples collected from rivers, local lakes, rain and spring waters were analyzed using the developed method. Results demonstrated that the hexagonal boron nitride-based material has significant potential as a sorbent for organic pollutant extraction from environmental water samples. Copyright © 2014 Elsevier B.V. All rights reserved.

Detecting coupling of Majorana bound states with an Aharonov-Bohm interferometer

NASA Astrophysics Data System (ADS)

Ramos-Andrade, J. P.; Orellana, P. A.; Ulloa, S. E.

2018-01-01

We study the transport properties of an interferometer composed by a quantum dot (QD) coupled with two normal leads and two one-dimensional topological superconductor nanowires (TNWs) hosting Majorana bound states (MBS) at their ends. The geometry considered is such that one TNW has both ends connected with the QD, forming an Aharonov-Bohm (AB) interferometer threaded by an external magnetic flux, while the other TNW is placed near the interferometer TNW. This geometry can alternatively be seen as a long wire contacted across a local defect, with possible coupling between independent-MBS. We use the Green’s function formalism to calculate the conductance across normal current leads on the QD. We find that the conductance exhibits a half-quantum value regardless of the AB phase and location of the dot energy level, whenever the interferometer configuration interacts with the neighboring TNW. These findings suggest that such a geometry could be used for a sensitive detection of MBS interactions across TNWs, exploiting the high sensitivity of conductance to the AB phase in the interferometer.

Gravitational waves from primordial black holes and new weak scale phenomena

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davoudiasl, Hooman; Giardino, Pier Paolo

Here, we entertain the possibility that primordial black holes of mass ~ (10 26–10 29)g, with Schwarzschild radii of O(cm), constitute ~ 10% or more of cosmic dark matter, as allowed by various constraints. These black holes would typically originate from cosmological eras corresponding to temperatures O(10-100)GeV, and may be associated with first order phase transitions in the visible or hidden sectors. In case these small primordial black holes get captured in orbits around neutron stars or astrophysical black holes in our galactic neighborhood, gravitational waves from the resulting “David and Goliath (D&G)” binaries could be detectable at Advanced LIGOmore » or Advanced Virgo for hours or more, possibly over distances of O(10)Mpc encompassing the Local Supercluster of galaxies. The proposed Einstein Telescope would further expand the reach for these signals. A positive signal could be further corroborated by the discovery of new particles in the O(10-100)GeV mass range, and potentially also the detection of long wavelength gravitational waves originating from the first order phase transition era.« less

Gravitational waves from primordial black holes and new weak scale phenomena

DOE PAGES

Davoudiasl, Hooman; Giardino, Pier Paolo

2017-02-24

Here, we entertain the possibility that primordial black holes of mass ~ (10 26–10 29)g, with Schwarzschild radii of O(cm), constitute ~ 10% or more of cosmic dark matter, as allowed by various constraints. These black holes would typically originate from cosmological eras corresponding to temperatures O(10-100)GeV, and may be associated with first order phase transitions in the visible or hidden sectors. In case these small primordial black holes get captured in orbits around neutron stars or astrophysical black holes in our galactic neighborhood, gravitational waves from the resulting “David and Goliath (D&G)” binaries could be detectable at Advanced LIGOmore » or Advanced Virgo for hours or more, possibly over distances of O(10)Mpc encompassing the Local Supercluster of galaxies. The proposed Einstein Telescope would further expand the reach for these signals. A positive signal could be further corroborated by the discovery of new particles in the O(10-100)GeV mass range, and potentially also the detection of long wavelength gravitational waves originating from the first order phase transition era.« less

Comparative study of different clean-up techniques for the determination of λ-cyhalothrin and cypermethrin in palm oil matrices by gas chromatography with electron capture detection.

PubMed

Muhamad, Halimah; Zainudin, Badrul Hisyam; Abu Bakar, Nor Kartini

2012-10-15

Solid phase extraction (SPE) and dispersive solid-phase extraction (d-SPE) were compared and evaluated for the determination of λ-cyhalothrin and cypermethrin in palm oil matrices by gas chromatography with an electron capture detector (GC-ECD). Several SPE sorbents such as graphitised carbon black (GCB), primary secondary amine (PSA), C(18), silica, and florisil were tested in order to minimise fat residues. The results show that mixed sorbents using GCB and PSA obtained cleaner extracts than a single GCB and PSA sorbents. The average recoveries obtained for each pesticide ranged between 81% and 114% at five fortification levels with the relative standard deviation of less than 7% in all cases. The limits of detection for these pesticides were ranged between 0.025 and 0.05 μg/g. The proposed method was applied successfully for the residue determination of both λ-cyhalothrin and cypermethrin in crude palm oil samples obtained from local mills throughout Malaysia. Copyright © 2012 Elsevier Ltd. All rights reserved.

Limited survey for the presence of aflatoxins in foods from local markets and supermarkets in Valencia, Spain.

PubMed

Blesa, J; Soriano, J M; Moltó, J C; Mañes, J

2004-02-01

Aflatoxin B1 (AFB1), B2 (AFB2), G1 (AFG1) and G2 (AFG2) were extracted by matrix solid-phase dispersion with C18 silica and acetonitrile as the eluting solvent, analysed by liquid chromatography with fluorescence detection and confirmed by liquid chromatography with mass spectrometry using an electrospray interface in 58 samples grouped as cereals, dried fruits, herbs and spices, pulses, snacks, and nuts and nut products collected from local markets and supermarkets in Valencia, Spain. All samples analysed by the proposed method were previously studied with an enzyme-linked immunosorbent assay as a screening protocol for the fast detection of mycotoxins. The samples containing residues (3/58) were hazelnut (0.42 and 0.52 microg kg(-1) for AFB1 and AFG1, respectively), nut cocktail (0.29 and 0.47 microg kg(-1) for AFB1 and AFG1, respectively) and pinhol (0.30 microg kg(-1) for AFG1). Such values were below the legislated maximum residue levels for the European Union.

Properties of traveling atmospheric disturbances (TADs) inferred from CHAMP accelerometer observations

NASA Astrophysics Data System (ADS)

Bruinsma, Sean L.; Forbes, Jeffrey M.

2009-02-01

Densities derived from accelerometer measurements on the CHAMP satellite near 400 km are used to statistically establish characteristics of large-scale (>1000 km) traveling atmospheric disturbances (TADs). Only TADs that at least propagate from the auroral zone to the equator are analyzed here, and a total of 21 identifiable events are found over the years 2001 2007. The average speed of all TADs, regardless of local time, is 646 ± 122 ms-1. The average speeds on the dayside and nightside are 595 ± 127 ms-1 and 685 ± 106 ms-1, respectively, i.e., the speed appears to be 10% higher on average on the nightside. On six occasions TADs were only detected on the night side; however, TADs on the dayside often appear more distinctly in the data. Moreover, contrary to some theoretical expectations, dayside TADs do not dissipate more readily than night side TADs, although much less are detected between 8 20 solar local time. No clear dependence of TAD amplitude or phase speed with respect to Kp, or rate of increase of Kp, is found.

Design of 2*6 optical hybrid in inter-satellite coherent laser communications

NASA Astrophysics Data System (ADS)

Xu, Nan; Liu, Liren; Liu, De'an; Wan, Lingyu; Zhou, Yu

2008-08-01

Compared with direct detection, homodyne binary phase shift keying receivers can achieve the best sensitivity theoretically, and became the trend of the research and application in inter-satellite coherent laser communications. In coherent optical communication systems an optical hybrid is an essential component of the receiver. It demodulates the incoming signal by mixing it with the local oscillator. We present a design of a 2*6 optical hybrid. 4 output ports of the hybrid give the narrow mixed beams of the incoming signal and the local oscillator shifted by 90°for communication, and the others give the wide mixed beams with a shifted degree of 180°for position errors detection. CCD captures the interference pattern from the wide beams, and then the pattern is processed and analyzed by the computer. Target position information is obtained from characteristic parameter of the interference pattern. The position errors as the control signals of PAT (pointing, acquisition and tracking) subsystem drive the receiver telescope to keep tracking to the target. The application extends to coherent laser rang finder.

Pressure-induced topological phase transitions and strongly anisotropic magnetoresistance in bulk black phosphorus

NASA Astrophysics Data System (ADS)

Li, Chun-Hong; Long, Yu-Jia; Zhao, Ling-Xiao; Shan, Lei; Ren, Zhi-An; Zhao, Jian-Zhou; Weng, Hong-Ming; Dai, Xi; Fang, Zhong; Ren, Cong; Chen, Gen-Fu

2017-03-01

We report the anisotropic magnetotransport measurement on a noncompound band semiconductor black phosphorus (BP) with magnetic field B up to 16 Tesla applied in both perpendicular and parallel to electric current I under hydrostatic pressures. The BP undergoes a topological Lifshitz transition from band semiconductor to a zero-gap Dirac semimetal state at a critical pressure Pc, characterized by a weak localization-weak antilocalization transition at low magnetic fields and the emergence of a nontrivial Berry phase of π detected by SdH magneto-oscillations in magnetoresistance curves. In the transition region, we observe a pressure-dependent negative MR only in the B ∥I configuration. This negative longitudinal MR is attributed to the Adler-Bell-Jackiw anomaly (topological E .B term) in the presence of weak antilocalization corrections.

Lattice dynamics and the nature of structural transitions in organolead halide perovskites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Comin, Riccardo; Crawford, Michael K.; Said, Ayman H.

Organolead halide perovskites are a family of hybrid organic-inorganic compounds whose remarkable optoelectronic properties have been under intensive scrutiny in recent years. Here we use inelastic x-ray scattering to study low-energy lattice excitations in single crystals of methylammonium lead iodide and bromide perovskites. Our findings confirm the displacive nature of the cubic-to-tetragonal phase transition, which is further shown, using neutron and x-ray diffraction, to be close to a tricritical point. Lastly, we detect quasistatic symmetry-breaking nanodomains persisting well into the high-temperature cubic phase, possibly stabilized by local defects. These findings reveal key structural properties of these materials, and also bearmore » important implications for carrier dynamics across an extended temperature range relevant for photovoltaic applications.« less

Comparative evaluation of [(99m)tc]tilmanocept for sentinel lymph node mapping in breast cancer patients: results of two phase 3 trials.

PubMed

Wallace, Anne M; Han, Linda K; Povoski, Stephen P; Deck, Kenneth; Schneebaum, Schlomo; Hall, Nathan C; Hoh, Carl K; Limmer, Karl K; Krontiras, Helen; Frazier, Thomas G; Cox, Charles; Avisar, Eli; Faries, Mark; King, Dennis W; Christman, Lori; Vera, David R

2013-08-01

Sentinel lymph node (SLN) surgery is used worldwide for staging breast cancer patients and helps limit axillary lymph node dissection. [(99m)Tc]Tilmanocept is a novel receptor-targeted radiopharmaceutical evaluated in 2 open-label, nonrandomized, within-patient, phase 3 trials designed to assess the lymphatic mapping performance. A total of 13 centers contributed 148 patients with breast cancer. Each patient received [(99m)Tc]tilmanocept and vital blue dye (VBD). Lymph nodes identified intraoperatively as radioactive and/or blue stained were excised and histologically examined. The primary endpoint, concordance (lower boundary set point at 90 %), was the proportion of nodes detected by VBD and [(99m)Tc]tilmanocept. A total of 13 centers contributed 148 patients who were injected with both agents. Intraoperatively, 207 of 209 nodes detected by VBD were also detected by [(99m)Tc]tilmanocept for a concordance rate of 99.04 % (p < 0.0001). [(99m)Tc]tilmanocept detected a total of 320 nodes, of which 207 (64.7 %) were detected by VBD. [(99m)Tc]Tilmanocept detected at least 1 SLN in more patients (146) than did VBD (131, p < 0.0001). In 129 of 131 patients with ≥1 blue node, all blue nodes were radioactive. Of 33 pathology-positive nodes (18.2 % patient pathology rate), [(99m)Tc]tilmanocept detected 31 of 33, whereas VBD detected only 25 of 33 (p = 0.0312). No pathology-positive SLNs were detected exclusively by VBD. No serious adverse events were attributed to [(99m)Tc]tilmanocept. [(99m)Tc]Tilmanocept demonstrated success in detecting a SLN while meeting the primary endpoint. Interestingly, [(99m)Tc]tilmanocept was additionally noted to identify more SLNs in more patients. This localization represented a higher number of metastatic breast cancer lymph nodes than that of VBD.

2D DOST based local phase pattern for face recognition

NASA Astrophysics Data System (ADS)

Moniruzzaman, Md.; Alam, Mohammad S.

2017-05-01

A new two dimensional (2-D) Discrete Orthogonal Stcokwell Transform (DOST) based Local Phase Pattern (LPP) technique has been proposed for efficient face recognition. The proposed technique uses 2-D DOST as preliminary preprocessing and local phase pattern to form robust feature signature which can effectively accommodate various 3D facial distortions and illumination variations. The S-transform, is an extension of the ideas of the continuous wavelet transform (CWT), is also known for its local spectral phase properties in time-frequency representation (TFR). It provides a frequency dependent resolution of the time-frequency space and absolutely referenced local phase information while maintaining a direct relationship with the Fourier spectrum which is unique in TFR. After utilizing 2-D Stransform as the preprocessing and build local phase pattern from extracted phase information yield fast and efficient technique for face recognition. The proposed technique shows better correlation discrimination compared to alternate pattern recognition techniques such as wavelet or Gabor based face recognition. The performance of the proposed method has been tested using the Yale and extended Yale facial database under different environments such as illumination variation and 3D changes in facial expressions. Test results show that the proposed technique yields better performance compared to alternate time-frequency representation (TFR) based face recognition techniques.

The Discriminant Value of Phase-Dependent Local Dynamic Stability of Daily Life Walking in Older Adult Community-Dwelling Fallers and Nonfallers

PubMed Central

Ihlen, Espen A. F.; Weiss, Aner; Helbostad, Jorunn L.; Hausdorff, Jeffrey M.

2015-01-01

The present study compares phase-dependent measures of local dynamic stability of daily life walking with 35 conventional gait features in their ability to discriminate between community-dwelling older fallers and nonfallers. The study reanalyzes 3D-acceleration data of 3-day daily life activity from 39 older people who reported less than 2 falls during one year and 31 who reported two or more falls. Phase-dependent local dynamic stability was defined for initial perturbation at 0%, 20%, 40%, 60%, and 80% of the step cycle. A partial least square discriminant analysis (PLS-DA) was used to compare the discriminant abilities of phase-dependent local dynamic stability with the discriminant abilities of 35 conventional gait features. The phase-dependent local dynamic stability λ at 0% and 60% of the step cycle discriminated well between fallers and nonfallers (AUC = 0.83) and was significantly larger (p < 0.01) for the nonfallers. Furthermore, phase-dependent λ discriminated as well between fallers and nonfallers as all other gait features combined. The present result suggests that phase-dependent measures of local dynamic stability of daily life walking might be of importance for further development in early fall risk screening tools. PMID:26491669

Many-body localization in Ising models with random long-range interactions

NASA Astrophysics Data System (ADS)

Li, Haoyuan; Wang, Jia; Liu, Xia-Ji; Hu, Hui

2016-12-01

We theoretically investigate the many-body localization phase transition in a one-dimensional Ising spin chain with random long-range spin-spin interactions, Vi j∝|i-j |-α , where the exponent of the interaction range α can be tuned from zero to infinitely large. By using exact diagonalization, we calculate the half-chain entanglement entropy and the energy spectral statistics and use them to characterize the phase transition towards the many-body localization phase at infinite temperature and at sufficiently large disorder strength. We perform finite-size scaling to extract the critical disorder strength and the critical exponent of the divergent localization length. With increasing α , the critical exponent experiences a sharp increase at about αc≃1.2 and then gradually decreases to a value found earlier in a disordered short-ranged interacting spin chain. For α <αc , we find that the system is mostly localized and the increase in the disorder strength may drive a transition between two many-body localized phases. In contrast, for α >αc , the transition is from a thermalized phase to the many-body localization phase. Our predictions could be experimentally tested with an ion-trap quantum emulator with programmable random long-range interactions, or with randomly distributed Rydberg atoms or polar molecules in lattices.

Spatial resolution of gas hydrate and permeability changes from ERT data in LARS simulating the Mallik gas hydrate production test

NASA Astrophysics Data System (ADS)

Priegnitz, Mike; Thaler, Jan; Spangenberg, Erik; Schicks, Judith M.; Abendroth, Sven

2014-05-01

The German gas hydrate project SUGAR studies innovative methods and approaches to be applied in the production of methane from hydrate-bearing reservoirs. To enable laboratory studies in pilot scale, a large reservoir simulator (LARS) was realized allowing for the formation and dissociation of gas hydrates under simulated in-situ conditions. LARS is equipped with a series of sensors. This includes a cylindrical electrical resistance tomography (ERT) array composed of 25 electrode rings featuring 15 electrodes each. The high-resolution ERT array is used to monitor the spatial distribution of the electrical resistivity during hydrate formation and dissociation experiments over time. As the present phases of poorly conducting sediment, well conducting pore fluid, non-conducting hydrates, and isolating free gas cover a wide range of electrical properties, ERT measurements enable us to monitor the spatial distribution of these phases during the experiments. In order to investigate the hydrate dissociation and the resulting fluid flow, we simulated a hydrate production test in LARS that was based on the Mallik gas hydrate production test (see abstract Heeschen et al., this volume). At first, a hydrate phase was produced from methane saturated saline water. During the two months of gas hydrate production we measured the electrical properties within the sediment sample every four hours. These data were used to establish a routine estimating both the local degrees of hydrate saturation and the resulting local permeabilities in the sediment's pore space from the measured resistivity data. The final gas hydrate saturation filled 89.5% of the total pore space. During hydrate dissociation, ERT data do not allow for a quantitative determination of free gas and remaining gas hydrates since both phases are electrically isolating. However, changes are resolved in the spatial distribution of the conducting liquid and the isolating phase with gas being the only mobile isolating phase. Hence, it is possible to detect areas in the sediment sample where free gas is released due to hydrate dissociation and displaces the liquid phase. Combined with measurements and numerical simulation of the total two-phase fluxes from the sediment sample (see abstract Abendroth et al., this volume), the LARS experiments allow for detailed information on the dissociation process during hydrate production. Here we present the workflow and first results estimating local hydrate saturations and permeabilities during hydrate formation and the movement of liquid and gas phases during hydrate dissociation, respectively.

Dynamic measurement of local displacements within curing resin-based dental composite using optical coherence elastography

NASA Astrophysics Data System (ADS)

Tomlins, Peter H.; Rahman, Mohammed Wahidur; Donnan, Robert S.

2016-04-01

This study aimed to determine the feasibility of using optical coherence elastography to measure internal displacements during the curing phase of a light-activated, resin-based composite material. Displacement vectors were spatially mapped over time within a commercial dental composite. Measurements revealed that the orientation of cure-induced displacement vectors varied spatially in a complex manner; however, each vector showed a systematic evolution with time. Precision of individual displacements was estimated to be ˜1 to 2 μm, enabling submicrometer time-varying displacements to be detected.

Chiral Majorana interference as a source of quantum entanglement

NASA Astrophysics Data System (ADS)

Chirolli, Luca; Baltanás, José Pablo; Frustaglia, Diego

2018-04-01

Two-particle Hanbury Brown-Twiss interferometry with chiral Majorana modes produces maximally entangled electron-hole pairs. We promote the electron-hole quantum number to an interferometric degree of freedom and complete the set of linear tools for single- and two-particle interferometry by introducing a key phase gate that, combined with a Mach-Zehnder, allows full electron-hole rotations. By considering entanglement witnesses built on current cross-correlation measurements, we find that the possibility of independent local-channel rotations in the electron-hole subspace leads to a significant boost of the entanglement detection power.

Local Sampling of the Wigner Function at Telecom Wavelength with Loss-Tolerant Detection of Photon Statistics.

PubMed

Harder, G; Silberhorn, Ch; Rehacek, J; Hradil, Z; Motka, L; Stoklasa, B; Sánchez-Soto, L L

2016-04-01

We report the experimental point-by-point sampling of the Wigner function for nonclassical states created in an ultrafast pulsed type-II parametric down-conversion source. We use a loss-tolerant time-multiplexed detector based on a fiber-optical setup and a pair of photon-number-resolving avalanche photodiodes. By capitalizing on an expedient data-pattern tomography, we assess the properties of the light states with outstanding accuracy. The method allows us to reliably infer the squeezing of genuine two-mode states without any phase reference.

Quantum melting of a two-dimensional Wigner crystal

NASA Astrophysics Data System (ADS)

Dolgopolov, V. T.

2017-10-01

The paper reviews theoretical predictions about the behavior of two-dimensional low-density electron systems at nearly absolute zero temperatures, including the formation of an electron (Wigner) crystal, crystal melting at a critical electron density, and transitions between crystal modifications in more complex (for example, two-layer) systems. The paper presents experimental results obtained from real two-dimensional systems in which the nonconducting (solid) state of the electronic system with indications of collective localization is actually realized. Experimental methods for detecting a quantum liquid-solid phase interface are discussed.

Local bias-induced phase transitions

DOE PAGES

Seal, Katyayani; Baddorf, Arthur P.; Jesse, Stephen; ...

2008-11-27

Electrical bias-induced phase transitions underpin a wide range of applications from data storage to energy generation and conversion. The mechanisms behind these transitions are often quite complex and in many cases are extremely sensitive to local defects that act as centers for local transformations or pinning. Furthermore, using ferroelectrics as an example, we review methods for probing bias-induced phase transitions and discuss the current limitations and challenges for extending the methods to field-induced phase transitions and electrochemical reactions in energy storage, biological and molecular systems.

An object-based visual attention model for robotic applications.

PubMed

Yu, Yuanlong; Mann, George K I; Gosine, Raymond G

2010-10-01

By extending integrated competition hypothesis, this paper presents an object-based visual attention model, which selects one object of interest using low-dimensional features, resulting that visual perception starts from a fast attentional selection procedure. The proposed attention model involves seven modules: learning of object representations stored in a long-term memory (LTM), preattentive processing, top-down biasing, bottom-up competition, mediation between top-down and bottom-up ways, generation of saliency maps, and perceptual completion processing. It works in two phases: learning phase and attending phase. In the learning phase, the corresponding object representation is trained statistically when one object is attended. A dual-coding object representation consisting of local and global codings is proposed. Intensity, color, and orientation features are used to build the local coding, and a contour feature is employed to constitute the global coding. In the attending phase, the model preattentively segments the visual field into discrete proto-objects using Gestalt rules at first. If a task-specific object is given, the model recalls the corresponding representation from LTM and deduces the task-relevant feature(s) to evaluate top-down biases. The mediation between automatic bottom-up competition and conscious top-down biasing is then performed to yield a location-based saliency map. By combination of location-based saliency within each proto-object, the proto-object-based saliency is evaluated. The most salient proto-object is selected for attention, and it is finally put into the perceptual completion processing module to yield a complete object region. This model has been applied into distinct tasks of robots: detection of task-specific stationary and moving objects. Experimental results under different conditions are shown to validate this model.

User compliance with documenting on a track and trigger-based observation and response chart: a two-phase multi-site audit study.

PubMed

Elliott, Doug; Allen, Emily; McKinley, Sharon; Perry, Lin; Duffield, Christine; Fry, Margaret; Gallagher, Robyn; Iedema, Rick; Roche, Michael

2017-12-01

To examine user compliance and completeness of documentation with a newly designed observation and response chart and whether a rapid response system call was triggered when clinically indicated. Timely recognition and responses to patient deterioration in hospital general wards remain a challenge for healthcare systems globally. Evaluating practice initiatives to improve recognition and response are required. Two-phase audit. Following introduction of the charts in ten health service sites in Australia, an audit of chart completion was conducted during a short trial for initial usability (Phase 1; 2011). After chart adoption as routine use in practice, retrospective and prospective chart audits were conducted (Phase 2; 2012). Overall, 818 and 1,058 charts were audited during the two phases respectively. Compliance was mixed but improved with the new chart (4%-14%). Contrary to chart guidelines, numbers rather than dots were written in the graphing section in 60% of cases. Rates of recognition of abnormal vital signs improved slightly with new charts in use, particularly for higher levels of surveillance and clinical review. Based on local calling criteria, an emergency call was initiated in 33% of cases during the retrospective audit and in 41% of cases with the new chart. User compliance was less than optimal, limiting full function of the chart sections and compliance with local calling criteria. Overcoming apparent behavioural and work culture barriers may improve chart completion, aiding identification of abnormal vital signs and triggering a rapid response system activation when clinical deterioration is detected. © 2017 The Authors. Journal of Advanced Nursing Published by John Wiley & Sons Ltd.

Cortical localization of phase and amplitude dynamics predicting access to somatosensory awareness.

PubMed

Hirvonen, Jonni; Palva, Satu

2016-01-01

Neural dynamics leading to conscious sensory perception have remained enigmatic in despite of large interest. Human functional magnetic resonance imaging (fMRI) studies have revealed that a co-activation of sensory and frontoparietal areas is crucial for conscious sensory perception in the several second time-scale of BOLD signal fluctuations. Electrophysiological recordings with magneto- and electroencephalography (MEG and EEG) and intracranial EEG (iEEG) have shown that event related responses (ERs), phase-locking of neuronal activity, and oscillation amplitude modulations in sub-second timescales are greater for consciously perceived than for unperceived stimuli. The cortical sources of ER and oscillation dynamics predicting the conscious perception have, however, remained unclear because these prior studies have utilized MEG/EEG sensor-level analyses or iEEG with limited neuroanatomical coverage. We used a somatosensory detection task, magnetoencephalography (MEG), and cortically constrained source reconstruction to identify the cortical areas where ERs, local poststimulus amplitudes and phase-locking of neuronal activity are predictive of the conscious access of somatosensory information. We show here that strengthened ERs, phase-locking to stimulus onset (SL), and induced oscillations amplitude modulations all predicted conscious somatosensory perception, but the most robust and widespread of these was SL that was sustained in low-alpha (6-10 Hz) band. The strength of SL and to a lesser extent that of ER predicted conscious perception in the somatosensory, lateral and medial frontal, posterior parietal, and in the cingulate cortex. These data suggest that a rapid phase-reorganization and concurrent oscillation amplitude modulations in these areas play an instrumental role in the emergence of a conscious percept. © 2015 Wiley Periodicals, Inc.

Optical communications and a comparison of optical technologies for a high data rate return link from Mars

NASA Technical Reports Server (NTRS)

Spence, Rodney L.

1993-01-01

The important principles of direct- and heterodyne-detection optical free-space communications are reviewed. Signal-to-noise-ratio (SNR) and bit-error-rate (BER) expressions are derived for both the direct-detection and heterodyne-detection optical receivers. For the heterodyne system, performance degradation resulting from received-signal and local oscillator-beam misalignment and laser phase noise is analyzed. Determination of interfering background power from local and extended background sources is discussed. The BER performance of direct- and heterodyne-detection optical links in the presence of Rayleigh-distributed random pointing and tracking errors is described. Finally, several optical systems employing Nd:YAG, GaAs, and CO2 laser sources are evaluated and compared to assess their feasibility in providing high-data-rate (10- to 1000-Mbps) Mars-to-Earth communications. It is shown that the root mean square (rms) pointing and tracking accuracy is a critical factor in defining the system transmitting laser-power requirements and telescope size and that, for a given rms error, there is an optimum telescope aperture size that minimizes the required power. The results of the analysis conducted indicate that, barring the achievement of extremely small rms pointing and tracking errors (less than 0.2 microrad), the two most promising types of optical systems are those that use an Nd:YAG laser (lambda = 1.064 microns) and high-order pulse position modulator (PPM) and direct detection, and those that use a CO2 laser (lambda = 10.6 microns) and phase shifting keying homodyne modulation and coherent detection. For example, for a PPM order of M = 64 and an rms pointing accuracy of 0.4 microrad, an Nd:YAG system can be used to implement a 100-Mbps Mars link with a 40-cm transmitting telescope, a 20-W laser, and a 10-m receiving photon bucket. Under the same conditions, a CO2 system would require 3-m transmitting and receiving telescopes and a 32-W laser to implement such a link. Other types of optical systems, such as a semiconductor laser systems, are impractical in the presence of large rms pointing errors because of the high power requirements of the 100-Mbps Mars link, even when optimal-size telescopes are used.

Local Cloudiness Development Forecast Based on Simulation of Solid Phase Formation Processes in the Atmosphere

NASA Astrophysics Data System (ADS)

Barodka, Siarhei; Kliutko, Yauhenia; Krasouski, Alexander; Papko, Iryna; Svetashev, Alexander; Turishev, Leonid

2013-04-01

Nowadays numerical simulation of thundercloud formation processes is of great interest as an actual problem from the practical point of view. Thunderclouds significantly affect airplane flights, and mesoscale weather forecast has much to contribute to facilitate the aviation forecast procedures. An accurate forecast can certainly help to avoid aviation accidents due to weather conditions. The present study focuses on modelling of the convective clouds development and thunder clouds detection on the basis of mesoscale atmospheric processes simulation, aiming at significantly improving the aeronautical forecast. In the analysis, the primary weather radar information has been used to be further adapted for mesoscale forecast systems. Two types of domains have been selected for modelling: an internal one (with radius of 8 km), and an external one (with radius of 300 km). The internal domain has been directly applied to study the local clouds development, and the external domain data has been treated as initial and final conditions for cloud cover formation. The domain height has been chosen according to the civil aviation forecast data (i.e. not exceeding 14 km). Simulations of weather conditions and local clouds development have been made within selected domains with the WRF modelling system. In several cases, thunderclouds are detected within the convective clouds. To specify the given category of clouds, we employ a simulation technique of solid phase formation processes in the atmosphere. Based on modelling results, we construct vertical profiles indicating the amount of solid phase in the atmosphere. Furthermore, we obtain profiles demonstrating the amount of ice particles and large particles (hailstones). While simulating the processes of solid phase formation, we investigate vertical and horizontal air flows. Consequently, we attempt to separate the total amount of solid phase into categories of small ice particles, large ice particles and hailstones. Also, we strive to reveal and differentiate the basic atmospheric parameters of sublimation and coagulation processes, aiming to predict ice particles precipitation. To analyze modelling results we apply the VAPOR three-dimensional visualization package. For the chosen domains, a diurnal synoptic situation has been simulated, including rain, sleet, ice pellets, and hail. As a result, we have obtained a large scope of data describing various atmospheric parameters: cloud cover, major wind components, basic levels of isobaric surfaces, and precipitation rate. Based on this data, we show both distinction in precipitation formation due to various heights and its differentiation of the ice particles. The relation between particle rise in the atmosphere and its size is analyzed: at 8-10 km altitude large ice particles, resulted from coagulation, dominate, while at 6-7 km altitude one can find snow and small ice particles formed by condensation growth. Also, mechanical trajectories of solid precipitation particles for various ice formation processes have been calculated.

Anderson Localization from the Berry-Curvature Interchange in Quantum Anomalous Hall Systems

NASA Astrophysics Data System (ADS)

Qiao, Zhenhua; Han, Yulei; Zhang, Lei; Wang, Ke; Deng, Xinzhou; Jiang, Hua; Yang, Shengyuan A.; Wang, Jian; Niu, Qian

2016-07-01

We theoretically investigate the localization mechanism of the quantum anomalous Hall effect (QAHE) in the presence of spin-flip disorders. We show that the QAHE stays quantized at weak disorders, then enters a Berry-curvature mediated metallic phase at moderate disorders, and finally goes into the Anderson insulating phase at strong disorders. From the phase diagram, we find that at the charge neutrality point although the QAHE is most robust against disorders, the corresponding metallic phase is much easier to be localized into the Anderson insulating phase due to the interchange of Berry curvatures carried, respectively, by the conduction and valence bands. In the end, we provide a phenomenological picture related to the topological charges to better understand the underlying physical origin of the QAHE Anderson localization.

Anderson Localization from the Berry-Curvature Interchange in Quantum Anomalous Hall Systems

NASA Astrophysics Data System (ADS)

Han, Yulei; Qiao, Zhenhua

In this talk, we theoretically investigate the localization mechanism of the quantum anomalous Hall effect (QAHE) in the presence of spin-flip disorders. We show that the QAHE stays quantized at weak disorders, then enters a Berry-curvature mediated metallic phase at moderate disorders, and finally goes into the Anderson insulating phase at strong disorders. From the phase diagram, we find that at the charge neutrality point although the QAHE is most robust against disorders, the corresponding metallic phase is much easier to be localized into the Anderson insulating phase due to the interchange of Berry curvatures carried, respectively, by the conduction and valence bands. In the end, we provide a phenomenological picture related to the topological charges to better understand the underlying physical origin of the QAHE Anderson localization.

Resolving phase information of the optical local density of state with scattering near-field probes

NASA Astrophysics Data System (ADS)

Prasad, R.; Vincent, R.

2016-10-01

We theoretically discuss the link between the phase measured using a scattering optical scanning near-field microscopy (s-SNOM) and the local density of optical states (LDOS). A remarkable result is that the LDOS information is directly included in the phase of the probe. Therefore by monitoring the spatial variation of the trans-scattering phase, we locally measure the phase modulation associated with the probe and the optical paths. We demonstrate numerically that a technique involving two-phase imaging of a sample with two different sized tips should allow to obtain the image the pLDOS. For this imaging method, numerical comparison with extinction probe measurement shows crucial qualitative and quantitative improvement.

Explosion Source Location Study Using Collocated Acoustic and Seismic Networks in Israel

NASA Astrophysics Data System (ADS)

Pinsky, V.; Gitterman, Y.; Arrowsmith, S.; Ben-Horin, Y.

2013-12-01

We explore a joined analysis of seismic and infrasonic signals for improvement in automatic monitoring of small local/regional events, such as construction and quarry blasts, military chemical explosions, sonic booms, etc. using collocated seismic and infrasonic networks recently build in Israel (ISIN) in the frame of the project sponsored by the Bi-national USA-Israel Science Foundation (BSF). The general target is to create an automatic system, which will provide detection, location and identification of explosions in real-time or close-to-real time manner. At the moment the network comprises 15 stations hosting a microphone and seismometer (or accelerometer), operated by the Geophysical Institute of Israel (GII), plus two infrasonic arrays, operated by the National Data Center, Soreq: IOB in the South (Negev desert) and IMA in the North of Israel (Upper Galilee),collocated with the IMS seismic array MMAI. The study utilizes a ground-truth data-base of numerous Rotem phosphate quarry blasts, a number of controlled explosions for demolition of outdated ammunitions and experimental surface explosions for a structure protection research, at the Sayarim Military Range. A special event, comprising four military explosions in a neighboring country, that provided both strong seismic (up to 400 km) and infrasound waves (up to 300 km), is also analyzed. For all of these events the ground-truth coordinates and/or the results of seismic location by the Israel Seismic Network (ISN) have been provided. For automatic event detection and phase picking we tested the new recursive picker, based on Statistically optimal detector. The results were compared to the manual picks. Several location techniques have been tested using the ground-truth event recordings and the preliminary results obtained have been compared to the ground-truth locations: 1) a number of events have been located as intersection of azimuths estimated using the wide-band F-K analysis technique applied to the infrasonic phases of the two distant arrays; 2) a standard robust grid-search location procedure based on phase picks and a constant celerity for a phase (tropospheric or stratospheric) was applied; 3) a joint coordinate grid-search procedure using array waveforms and phase picks was tested, 4) the Bayesian Infrasonic Source Localization (BISL) method, incorporating semi-empirical model-based prior information, was modified for array+network configuration and applied to the ground-truth events. For this purpose we accumulated data of the former observations of the air-to-ground infrasonic phases to compute station specific ground-truth Celerity-Range Histograms (ssgtCRH) and/or model-based CRH (mbCRH), which allow to essentially improve the location results. For building the mbCRH the local meteo-data and the ray-tracing modeling in 3 available azimuth ranges, accounting seasonal variations of winds directivity (quadrants North:315-45, South: 135-225, East 45-135) have been used.

Properties, propagation, and excitation of EMIC waves observed by MMS: A case study

NASA Astrophysics Data System (ADS)

Zhang, J.; Boardsen, S. A.; Coffey, V. N.; Chandler, M. O.; Saikin, A.; Mello, E. M.; Russell, C. T.; Torbert, R. B.; Fuselier, S. A.; Giles, B. L.; Gershman, D. J.

2017-12-01

Electromagnetic ion cyclotron (EMIC) waves (0.1-5 Hz) play an important role in particle dynamics in the Earth's magnetosphere. EMIC waves are preferentially excited in regions where hot anisotropic ions and cold dense plasma populations spatially overlap. While the generation region of EMIC waves is usually on or near the magnetic equatorial plane in the inner magnetosphere, EMIC waves have both equatorial and off-equator source regions on the dayside in the compressed outer magnetosphere. Using field and plasma measurements from the Magnetospheric Multiscale (MMS) mission, we perform a case study of EMIC waves and associated local plasma conditions observed on 19 October 2015. From 0315 to 0810 UT, before crossing the magnetopause into the magnetosheath, all four MMS spacecraft detected long-lasting He+-band EMIC wave emissions around local noon (MLT = 12.7 - 14.0) at high L-shells (L = 8.8 - 15.2) and low magnetic latitudes (MLAT = -21.8º - -30.3º). Energetic (> 1 keV) and anisotropic ions were present throughout this event that was in the recovery phase of a weak geomagnetic storm (min. Dst = -48 nT at 1000 UT on 18 October 2015). The testing of linear theory suggests that the EMIC waves were excited locally. Although the wave event is dominated by small normal angles, its polarization is mixed with right- and left-handedness and its propagation is bi-directional with regard to the background magnetic field. The short inter-spacecraft distances (as low as 15 km) of the MMS mission make it possible to accurately determine the k vector of the waves using the phase difference technique. Preliminary analysis finds that the k vector magnitude, phase speed, and wavelength of the 0.3-Hz wave packet at 0453:55 UT are 0.005 km-1, 372.9 km/s, and 1242.9 km, respectively. We will discuss the characteristics of the wave and particle measurements and their significance in this locale.

SU-G-JeP3-01: A Method to Quantify Lung SBRT Target Localization Accuracy Based On Digitally Reconstructed Fluoroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lafata, K; Ren, L; Cai, J

2016-06-15

Purpose: To develop a methodology based on digitally-reconstructed-fluoroscopy (DRF) to quantitatively assess target localization accuracy of lung SBRT, and to evaluate using both a dynamic digital phantom and a patient dataset. Methods: For each treatment field, a 10-phase DRF is generated based on the planning 4DCT. Each frame is pre-processed with a morphological top-hat filter, and corresponding beam apertures are projected to each detector plane. A template-matching algorithm based on cross-correlation is used to detect the tumor location in each frame. Tumor motion relative beam aperture is extracted in the superior-inferior direction based on each frame’s impulse response to themore » template, and the mean tumor position (MTP) is calculated as the average tumor displacement. The DRF template coordinates are then transferred to the corresponding MV-cine dataset, which is retrospectively filtered as above. The treatment MTP is calculated within each field’s projection space, relative to the DRF-defined template. The field’s localization error is defined as the difference between the DRF-derived-MTP (planning) and the MV-cine-derived-MTP (delivery). A dynamic digital phantom was used to assess the algorithm’s ability to detect intra-fractional changes in patient alignment, by simulating different spatial variations in the MV-cine and calculating the corresponding change in MTP. Inter-and-intra-fractional variation, IGRT accuracy, and filtering effects were investigated on a patient dataset. Results: Phantom results demonstrated a high accuracy in detecting both translational and rotational variation. The lowest localization error of the patient dataset was achieved at each fraction’s first field (mean=0.38mm), with Fx3 demonstrating a particularly strong correlation between intra-fractional motion-caused localization error and treatment progress. Filtering significantly improved tracking visibility in both the DRF and MV-cine images. Conclusion: We have developed and evaluated a methodology to quantify lung SBRT target localization accuracy based on digitally-reconstructed-fluoroscopy. Our approach may be useful in potentially reducing treatment margins to optimize lung SBRT outcomes. R01-184173.« less

Fast fMRI can detect oscillatory neural activity in humans.

PubMed

Lewis, Laura D; Setsompop, Kawin; Rosen, Bruce R; Polimeni, Jonathan R

2016-10-25

Oscillatory neural dynamics play an important role in the coordination of large-scale brain networks. High-level cognitive processes depend on dynamics evolving over hundreds of milliseconds, so measuring neural activity in this frequency range is important for cognitive neuroscience. However, current noninvasive neuroimaging methods are not able to precisely localize oscillatory neural activity above 0.2 Hz. Electroencephalography and magnetoencephalography have limited spatial resolution, whereas fMRI has limited temporal resolution because it measures vascular responses rather than directly recording neural activity. We hypothesized that the recent development of fast fMRI techniques, combined with the extra sensitivity afforded by ultra-high-field systems, could enable precise localization of neural oscillations. We tested whether fMRI can detect neural oscillations using human visual cortex as a model system. We detected small oscillatory fMRI signals in response to stimuli oscillating at up to 0.75 Hz within single scan sessions, and these responses were an order of magnitude larger than predicted by canonical linear models. Simultaneous EEG-fMRI and simulations based on a biophysical model of the hemodynamic response to neuronal activity suggested that the blood oxygen level-dependent response becomes faster for rapidly varying stimuli, enabling the detection of higher frequencies than expected. Accounting for phase delays across voxels further improved detection, demonstrating that identifying vascular delays will be of increasing importance with higher-frequency activity. These results challenge the assumption that the hemodynamic response is slow, and demonstrate that fMRI has the potential to map neural oscillations directly throughout the brain.

Plils: A Practical Indoor Localization System through Less Expensive Wireless Chips via Subregion Clustering

PubMed Central

Cai, Jun; Deng, Yun; Yang, Junfeng; Zhou, Xinmin; Tan, Lina

2018-01-01

Reducing costs is a pragmatic method for promoting the widespread usage of indoor localization technology. Conventional indoor localization systems (ILSs) exploit relatively expensive wireless chips to measure received signal strength for positioning. Our work is based on a cheap and widely-used commercial off-the-shelf (COTS) wireless chip, i.e., the Nordic Semiconductor nRF24LE1, which has only several output power levels, and proposes a new power level based-ILS, called Plils. The localization procedure incorporates two phases: an offline training phase and an online localization phase. In the offline training phase, a self-organizing map (SOM) is utilized for dividing a target area into k subregions, wherein their grids in the same subregion have similar fingerprints. In the online localization phase, the support vector machine (SVM) and back propagation (BP) neural network methods are adopted to identify which subregion a tagged object is located in, and calculate its exact location, respectively. The reasonable value for k has been discussed as well. Our experiments show that Plils achieves 75 cm accuracy on average, and is robust to indoor obstacles. PMID:29329226

Plils: A Practical Indoor Localization System through Less Expensive Wireless Chips via Subregion Clustering.

PubMed

Li, Xiaolong; Yang, Yifu; Cai, Jun; Deng, Yun; Yang, Junfeng; Zhou, Xinmin; Tan, Lina

2018-01-12

Reducing costs is a pragmatic method for promoting the widespread usage of indoor localization technology. Conventional indoor localization systems (ILSs) exploit relatively expensive wireless chips to measure received signal strength for positioning. Our work is based on a cheap and widely-used commercial off-the-shelf (COTS) wireless chip, i.e., the Nordic Semiconductor nRF24LE1, which has only several output power levels, and proposes a new power level based-ILS, called Plils. The localization procedure incorporates two phases: an offline training phase and an online localization phase. In the offline training phase, a self-organizing map (SOM) is utilized for dividing a target area into k subregions, wherein their grids in the same subregion have similar fingerprints. In the online localization phase, the support vector machine (SVM) and back propagation (BP) neural network methods are adopted to identify which subregion a tagged object is located in, and calculate its exact location, respectively. The reasonable value for k has been discussed as well. Our experiments show that Plils achieves 75 cm accuracy on average, and is robust to indoor obstacles.

A comparative study on book shelf structure based on different domain modal analysis

NASA Astrophysics Data System (ADS)

Sabamehr, Ardalan; Roy, Timir Baran; Bagchi, Ashutosh

2017-04-01

Structural Health Monitoring (SHM) based on the vibration of structures has been very attractive topic for researchers in different fields such as: civil, aeronautical and mechanical engineering. The aim of this paper is to compare three most common modal identification techniques such as Frequency Domain Decomposition (FDD), Stochastic Subspace Identification (SSI) and Continuous Wavelet Transform (CWT) to find modal properties (such as natural frequency, mode shape and damping ratio) of three story book shelf steel structure which was built in Concordia University Lab. The modified Complex Morlet wavelet have been selected for wavelet in order to use asymptotic signal rather than real one with variable bandwidth and wavelet central frequency. So, CWT is able to detect instantaneous modulus and phase by use of local maxima ridge detection.

Vision-based weld pool boundary extraction and width measurement during keyhole fiber laser welding

NASA Astrophysics Data System (ADS)

Luo, Masiyang; Shin, Yung C.

2015-01-01

In keyhole fiber laser welding processes, the weld pool behavior is essential to determining welding quality. To better observe and control the welding process, the accurate extraction of the weld pool boundary as well as the width is required. This work presents a weld pool edge detection technique based on an off axial green illumination laser and a coaxial image capturing system that consists of a CMOS camera and optic filters. According to the difference of image quality, a complete developed edge detection algorithm is proposed based on the local maximum gradient of greyness searching approach and linear interpolation. The extracted weld pool geometry and the width are validated by the actual welding width measurement and predictions by a numerical multi-phase model.

Investigations of acoustic-seismic effects at long range - Early-arriving seismic waves from Apollo 16

NASA Technical Reports Server (NTRS)

Dalins, I.; Mccarty, V. M.; Kaschak, G.; Donn, W. L.

1974-01-01

A reasonably comprehensive technical effort is described dealing with the investigations of acoustically generated seismic waves of Apollo 16 and Apollo 17 origin along the eastern seabord of the United States. This expanded effort is a continuation of earlier, rather successful detections of rocket-generated seismic disturbances on Skidaway Island, Georgia. The more recent effort has yielded few positive results other than a recording of an early-arriving seismic wave from Apollo 16 that was detected in Jacksonville. Evaluation of the negative results obtained in the Fort Monmouth area, with earlier studies of infrasound, local weather conditions, and geology, could be advantageous in the process of trying to gain a better insight into the acoustic-seismic resonance mechanism requiring phase-velocity matching at the atmosphere-ground interface.

Learning to predict where human gaze is using quaternion DCT based regional saliency detection

NASA Astrophysics Data System (ADS)

Li, Ting; Xu, Yi; Zhang, Chongyang

2014-09-01

Many current visual attention approaches used semantic features to accurately capture human gaze. However, these approaches demand high computational cost and can hardly be applied to daily use. Recently, some quaternion-based saliency detection models, such as PQFT (phase spectrum of Quaternion Fourier Transform), QDCT (Quaternion Discrete Cosine Transform), have been proposed to meet real-time requirement of human gaze tracking tasks. However, current saliency detection methods used global PQFT and QDCT to locate jump edges of the input, which can hardly detect the object boundaries accurately. To address the problem, we improved QDCT-based saliency detection model by introducing superpixel-wised regional saliency detection mechanism. The local smoothness of saliency value distribution is emphasized to distinguish noises of background from salient regions. Our algorithm called saliency confidence can distinguish the patches belonging to the salient object and those of the background. It decides whether the image patches belong to the same region. When an image patch belongs to a region consisting of other salient patches, this patch should be salient as well. Therefore, we use saliency confidence map to get background weight and foreground weight to do the optimization on saliency map obtained by QDCT. The optimization is accomplished by least square method. The optimization approach we proposed unifies local and global saliency by combination of QDCT and measuring the similarity between each image superpixel. We evaluate our model on four commonly-used datasets (Toronto, MIT, OSIE and ASD) using standard precision-recall curves (PR curves), the mean absolute error (MAE) and area under curve (AUC) measures. In comparison with most state-of-art models, our approach can achieve higher consistency with human perception without training. It can get accurate human gaze even in cluttered background. Furthermore, it achieves better compromise between speed and accuracy.

Orbital apocenter is not a sufficient condition for HST/STIS detection of Europa’s water vapor aurora

PubMed Central

Retherford, Kurt D.; Saur, Joachim; Strobel, Darrell F.; Feldman, Paul D.; McGrath, Melissa A.; Nimmo, Francis

2014-01-01

We report far-ultraviolet observations of Jupiter’s moon Europa taken by Space Telescope Imaging Spectrograph (STIS) of the Hubble Space Telescope (HST) in January and February 2014 to test the hypothesis that the discovery of a water vapor aurora in December 2012 by local hydrogen (H) and oxygen (O) emissions with the STIS originated from plume activity possibly correlated with Europa’s distance from Jupiter through tidal stress variations. The 2014 observations were scheduled with Europa near the apocenter similar to the orbital position of its previous detection. Tensile stresses on south polar fractures are expected to be highest in this orbital phase, potentially maximizing the probability for plume activity. No local H and O emissions were detected in the new STIS images. In the south polar region where the emission surpluses were observed in 2012, the brightnesses are sufficiently low in the 2014 images to be consistent with any H2O abundance from (0–5)×1015 cm−2. Large high-latitude plumes should have been detectable by the STIS, independent of the observing conditions and geometry. Because electron excitation of water vapor remains the only viable explanation for the 2012 detection, the new observations indicate that although the same orbital position of Europa for plume activity may be a necessary condition, it is not a sufficient condition. However, the December 2012 detection of coincident HI Lyman-α and OI 1304-Å emission surpluses in an ∼200-km high region well separated above Europa’s limb is a firm result and not invalidated by our 2014 STIS observations. PMID:25404343

Change Detection Based on Persistent Scatterer Interferometry - a New Method of Monitoring Building Changes

NASA Astrophysics Data System (ADS)

Yang, C. H.; Kenduiywo, B. K.; Soergel, U.

2016-06-01

Persistent Scatterer Interferometry (PSI) is a technique to detect a network of extracted persistent scatterer (PS) points which feature temporal phase stability and strong radar signal throughout time-series of SAR images. The small surface deformations on such PS points are estimated. PSI particularly works well in monitoring human settlements because regular substructures of man-made objects give rise to large number of PS points. If such structures and/or substructures substantially alter or even vanish due to big change like construction, their PS points are discarded without additional explorations during standard PSI procedure. Such rejected points are called big change (BC) points. On the other hand, incoherent change detection (ICD) relies on local comparison of multi-temporal images (e.g. image difference, image ratio) to highlight scene modifications of larger size rather than detail level. However, image noise inevitably degrades ICD accuracy. We propose a change detection approach based on PSI to synergize benefits of PSI and ICD. PS points are extracted by PSI procedure. A local change index is introduced to quantify probability of a big change for each point. We propose an automatic thresholding method adopting change index to extract BC points along with a clue of the period they emerge. In the end, PS ad BC points are integrated into a change detection image. Our method is tested at a site located around north of Berlin main station where steady, demolished, and erected building substructures are successfully detected. The results are consistent with ground truth derived from time-series of aerial images provided by Google Earth. In addition, we apply our technique for traffic infrastructure, business district, and sports playground monitoring.

Low temperature electroweak phase transition in the Standard Model with hidden scale invariance

NASA Astrophysics Data System (ADS)

Arunasalam, Suntharan; Kobakhidze, Archil; Lagger, Cyril; Liang, Shelley; Zhou, Albert

2018-01-01

We discuss a cosmological phase transition within the Standard Model which incorporates spontaneously broken scale invariance as a low-energy theory. In addition to the Standard Model fields, the minimal model involves a light dilaton, which acquires a large vacuum expectation value (VEV) through the mechanism of dimensional transmutation. Under the assumption of the cancellation of the vacuum energy, the dilaton develops a very small mass at 2-loop order. As a result, a flat direction is present in the classical dilaton-Higgs potential at zero temperature while the quantum potential admits two (almost) degenerate local minima with unbroken and broken electroweak symmetry. We found that the cosmological electroweak phase transition in this model can only be triggered by a QCD chiral symmetry breaking phase transition at low temperatures, T ≲ 132 MeV. Furthermore, unlike the standard case, the universe settles into the chiral symmetry breaking vacuum via a first-order phase transition which gives rise to a stochastic gravitational background with a peak frequency ∼10-8 Hz as well as triggers the production of approximately solar mass primordial black holes. The observation of these signatures of cosmological phase transitions together with the detection of a light dilaton would provide a strong hint of the fundamental role of scale invariance in particle physics.

Competitive aggregation dynamics using phase wave signals.

PubMed

Sakaguchi, Hidetsugu; Maeyama, Satomi

2014-10-21

Coupled equations of the phase equation and the equation of cell concentration n are proposed for competitive aggregation dynamics of slime mold in two dimensions. Phase waves are used as tactic signals of aggregation in this model. Several aggregation clusters are formed initially, and target patterns appear around the localized aggregation clusters. Owing to the competition among target patterns, the number of the localized aggregation clusters decreases, and finally one dominant localized pattern survives. If the phase equation is replaced with the complex Ginzburg-Landau equation, several spiral patterns appear, and n is localized near the center of the spiral patterns. After the competition among spiral patterns, one dominant spiral survives. Copyright © 2014 Elsevier Ltd. All rights reserved.

Fully automated contour detection of the ascending aorta in cardiac 2D phase-contrast MRI.

PubMed

Codari, Marina; Scarabello, Marco; Secchi, Francesco; Sforza, Chiarella; Baselli, Giuseppe; Sardanelli, Francesco

2018-04-01

In this study we proposed a fully automated method for localizing and segmenting the ascending aortic lumen with phase-contrast magnetic resonance imaging (PC-MRI). Twenty-five phase-contrast series were randomly selected out of a large population dataset of patients whose cardiac MRI examination, performed from September 2008 to October 2013, was unremarkable. The local Ethical Committee approved this retrospective study. The ascending aorta was automatically identified on each phase of the cardiac cycle using a priori knowledge of aortic geometry. The frame that maximized the area, eccentricity, and solidity parameters was chosen for unsupervised initialization. Aortic segmentation was performed on each frame using active contouring without edges techniques. The entire algorithm was developed using Matlab R2016b. To validate the proposed method, the manual segmentation performed by a highly experienced operator was used. Dice similarity coefficient, Bland-Altman analysis, and Pearson's correlation coefficient were used as performance metrics. Comparing automated and manual segmentation of the aortic lumen on 714 images, Bland-Altman analysis showed a bias of -6.68mm 2 , a coefficient of repeatability of 91.22mm 2 , a mean area measurement of 581.40mm 2 , and a reproducibility of 85%. Automated and manual segmentation were highly correlated (R=0.98). The Dice similarity coefficient versus the manual reference standard was 94.6±2.1% (mean±standard deviation). A fully automated and robust method for identification and segmentation of ascending aorta on PC-MRI was developed. Its application on patients with a variety of pathologic conditions is advisable. Copyright © 2017 Elsevier Inc. All rights reserved.

Label-free detection of 3-nitro-l-tyrosine with nickel-doped graphene localized surface plasmon resonance biosensor.

PubMed

Ng, Siu Pang; Qiu, Guangyu; Ding, Ning; Lu, Xiaoqing; Wu, Chi-Man Lawrence

2017-03-15

3-nitro-l-tyrosine (3-NT) is believed to be a biomarker of neurodegenerative diseases and metal doped graphene possess exceptionally high binding energy of 3-NT with metal-nitro chemisorption. Here we report a novel label-free detection scheme of 3-NT via nickel-doped graphene (NDG) as the functionalized receptor on our phase detecting localized surface plasmon resonance (LSPR) biosensor. When compared with reported 3-NT immunoassay with enzyme-linked immunosorbent assay (ELISA), our NDG-LSPR platform offers two advantages i.e. 1) label-free and 2) capture of 3-NT by direct chemisorption. Our limit of detection for 3-NT in PBS was found to be 0.13pg/ml and the linear dynamic range of response was from 0.5pg/ml to 1ng/ml, i.e. four orders of magnitude. The specificity of our NDG receptor to 3-NT was also verified with l-tyrosine of equivalent concentrations in PBS and diluted human serum, for which the NDG receptor shows negligible responses. In addition, the adsorption of 3-NT and l-tyrosine to the NDG receptor were also investigated by atomic force microscopy and further verified by surface enhanced Raman spectroscopy. Therefore, our NDG-LSPR biosensor competes favorably against ELISA and we believe it should be an attractive and economical solution to early diagnostic of 3-NT related disorders for clinical applications. Copyright © 2016 Elsevier B.V. All rights reserved.

Design of Dual-Mode Local Oscillators Using CMOS Technology for Motion Detection Sensors.

PubMed

Ha, Keum-Won; Lee, Jeong-Yun; Kim, Jeong-Geun; Baek, Donghyun

2018-04-01

Recently, studies have been actively carried out to implement motion detecting sensors by applying radar techniques. Doppler radar or frequency-modulated continuous wave (FMCW) radar are mainly used, but each type has drawbacks. In Doppler radar, no signal is detected when the movement is stopped. Also, FMCW radar cannot function when the detection object is near the sensor. Therefore, by implementing a single continuous wave (CW) radar for operating in dual-mode, the disadvantages in each mode can be compensated for. In this paper, a dual mode local oscillator (LO) is proposed that makes a CW radar operate as a Doppler or FMCW radar. To make the dual-mode LO, a method that controls the division ratio of the phase locked loop (PLL) is used. To support both radar mode easily, the proposed LO is implemented by adding a frequency sweep generator (FSG) block to a fractional-N PLL. The operation mode of the LO is determined by according to whether this block is operating or not. Since most radar sensors are used in conjunction with microcontroller units (MCUs), the proposed architecture is capable of dual-mode operation by changing only the input control code. In addition, all components such as VCO, LDO, and loop filter are integrated into the chip, so complexity and interface issues can be solved when implementing radar sensors. Thus, the proposed dual-mode LO is suitable as a radar sensor.

Design of Dual-Mode Local Oscillators Using CMOS Technology for Motion Detection Sensors

PubMed Central

Lee, Jeong-Yun; Kim, Jeong-Geun

2018-01-01

Recently, studies have been actively carried out to implement motion detecting sensors by applying radar techniques. Doppler radar or frequency-modulated continuous wave (FMCW) radar are mainly used, but each type has drawbacks. In Doppler radar, no signal is detected when the movement is stopped. Also, FMCW radar cannot function when the detection object is near the sensor. Therefore, by implementing a single continuous wave (CW) radar for operating in dual-mode, the disadvantages in each mode can be compensated for. In this paper, a dual mode local oscillator (LO) is proposed that makes a CW radar operate as a Doppler or FMCW radar. To make the dual-mode LO, a method that controls the division ratio of the phase locked loop (PLL) is used. To support both radar mode easily, the proposed LO is implemented by adding a frequency sweep generator (FSG) block to a fractional-N PLL. The operation mode of the LO is determined by according to whether this block is operating or not. Since most radar sensors are used in conjunction with microcontroller units (MCUs), the proposed architecture is capable of dual-mode operation by changing only the input control code. In addition, all components such as VCO, LDO, and loop filter are integrated into the chip, so complexity and interface issues can be solved when implementing radar sensors. Thus, the proposed dual-mode LO is suitable as a radar sensor. PMID:29614777

Fast and accurate spectral estimation for online detection of partial broken bar in induction motors

NASA Astrophysics Data System (ADS)

Samanta, Anik Kumar; Naha, Arunava; Routray, Aurobinda; Deb, Alok Kanti

2018-01-01

In this paper, an online and real-time system is presented for detecting partial broken rotor bar (BRB) of inverter-fed squirrel cage induction motors under light load condition. This system with minor modifications can detect any fault that affects the stator current. A fast and accurate spectral estimator based on the theory of Rayleigh quotient is proposed for detecting the spectral signature of BRB. The proposed spectral estimator can precisely determine the relative amplitude of fault sidebands and has low complexity compared to available high-resolution subspace-based spectral estimators. Detection of low-amplitude fault components has been improved by removing the high-amplitude fundamental frequency using an extended-Kalman based signal conditioner. Slip is estimated from the stator current spectrum for accurate localization of the fault component. Complexity and cost of sensors are minimal as only a single-phase stator current is required. The hardware implementation has been carried out on an Intel i7 based embedded target ported through the Simulink Real-Time. Evaluation of threshold and detectability of faults with different conditions of load and fault severity are carried out with empirical cumulative distribution function.

Detection of the 2015 Gorkha earthquake-induced landslide surface deformation in Kathmandu using InSAR images from PALSAR-2 data

NASA Astrophysics Data System (ADS)

Sato, Hiroshi P.; Une, Hiroshi

2016-03-01

Previous studies reported that the 2015 Gorkha earthquake (Mw 7.8), which occurred in Nepal, triggered landslides in mountainous areas. In Kathmandu, earthquake-induced land subsidence was identified by interpreting local phase changes in interferograms produced from Advanced Land Observing Satellite-2/Phased Array type L-band Synthetic Aperture Radar-2 data. However, the associated ground deformation was not discussed in detail. We studied line-of-sight (LoS) changes from InSAR images in the SE area of Tribhuvan International Airport, Kathmandu. To obtain the change in LoS caused only by local, short-wavelength surface deformation, we subtracted the change in LoS attributed to coseismic deformation from the original change in LoS. The resulting change in LoS showed that the river terrace was driven to the bottom of the river valley. We also studied the changes in LoS in both ascending and descending InSAR images of the area along the Bishnumati River and performed 2.5D analysis. Removing the effect of coseismic deformation revealed east-west and up-down components of local surface deformation, indicating that the river terrace deformed eastward and subsided on the western riverbank of the river. On the east riverbank, the river terrace deformed westward and subsided. However, in the southern part of the river basin, the river terrace deformed westward and was uplifted. The deformation data and field survey results indicate that local surface deformation in these two areas was not caused by land subsidence but by a landslide (specifically, lateral spread).

Response of ionospheric electric fields at mid-low latitudes during sudden commencements

NASA Astrophysics Data System (ADS)

Takahashi, N.; Kasaba, Y.; Shinbori, A.; Nishimura, Y.; Kikuchi, T.; Ebihara, Y.; Nagatsuma, T.

2015-06-01

Using in situ observations from the Republic of China Satellite-1 spacecraft, we investigated the time response and local time dependence of the ionospheric electric field at mid-low latitudes associated with geomagnetic sudden commencements (SCs) that occurred from 1999 to 2004. We found that the ionospheric electric field variation associated with SCs instantaneously responds to the preliminary impulse (PI) signature on the ground regardless of spacecraft local time. Our statistical analysis also supports the global instant transmission of electric field from the polar region. In contrast, the peak time detected in the ionospheric electric field is earlier than that of the equatorial geomagnetic field (~20 s before in the PI phase). Based on the ground-ionosphere waveguide model, this time lag can be attributed to the latitudinal difference of ionospheric conductivity. However, the local time distribution of the initial excursion of ionospheric electric field shows that dusk-to-dawn ionospheric electric fields develop during the PI phase. Moreover, the westward electric field in the ionosphere, which produces the preliminary reverse impulse of the geomagnetic field on the dayside feature, appears at 18-22 h LT where the ionospheric conductivity beyond the duskside terminator (18 h LT) is lower than on the dayside. The result of a magnetohydrodynamic simulation for an ideal SC shows that the electric potential distribution is asymmetric with respect to the noon-midnight meridian. This produces the local time distribution of ionospheric electric fields similar to the observed result, which can be explained by the divergence of the Hall current under nonuniform ionospheric conductivity.

GBT Detection of Polarization-Dependent HI Absorption and HI Outflows in Local ULIRGs and Quasars

NASA Technical Reports Server (NTRS)

Teng, Stacy H.; Veilleux, Sylvain; Baker, Andrew J.

2013-01-01

We present the results of a 21-cm HI survey of 27 local massive gas-rich late-stage mergers and merger remnants with the Green Bank Telescope (GBT). These remnants were selected from the Quasar/ULIRG Evolution Study (QUEST) sample of ultraluminous infrared galaxies (ULIRGs; L(sub 8 - 1000 micron) > 10(exp 12) solar L) and quasars; our targets are all bolometrically dominated by active galactic nuclei (AGN) and sample the later phases of the proposed ULIRG-to-quasar evolutionary sequence. We find the prevalence of HI absorption (emission) to be 100% (29%) in ULIRGs with HI detections, 100% (88%) in FIR-strong quasars, and 63% (100%) in FIR-weak quasars. The absorption features are associated with powerful neutral outflows that change from being mainly driven by star formation in ULIRGs to being driven by the AGN in the quasars. These outflows have velocities that exceed 1500 km/s in some cases. Unexpectedly, we find polarization-dependent HI absorption in 57% of our spectra (88% and 63% of the FIR-strong and FIR-weak quasars, respectively). We attribute this result to absorption of polarized continuum emission from these sources by foreground HI clouds. About 60% of the quasars displaying polarized spectra are radio-loud, far higher than the approx 10% observed in the general AGN population. This discrepancy suggests that radio jets play an important role in shaping the environments in these galaxies. These systems may represent a transition phase in the evolution of gas-rich mergers into "mature" radio galaxies.

Unraveling the Underlying Arrhythmia Mechanism in Persistent Atrial Fibrillation: Results From the STARLIGHT Study.

PubMed

Child, Nicholas; Clayton, Richard H; Roney, Caroline R; Laughner, Jacob I; Shuros, Allan; Neuzil, Petr; Petru, Jan; Jackson, Tom; Porter, Bradley; Bostock, Julian; Niederer, Steven A; Razavi, Reza S; Rinaldi, Christopher A; Taggart, Peter; Wright, Matthew J; Gill, Jaswinder

2018-06-01

The mechanisms that initiate and sustain persistent atrial fibrillation are not well characterized. Ablation results remain significantly worse than in paroxysmal atrial fibrillation in which the mechanism is better understood and subsequent targeted therapy has been developed. The aim of this study was to characterize and quantify patterns of activation during atrial fibrillation using contact mapping. Patients with persistent atrial fibrillation (n=14; mean age, 61±8 years; ejection fraction, 59±10%) underwent simultaneous biatrial contact mapping with 64 electrode catheters. The atrial electrograms were transformed into phase, and subsequent spatiotemporal mapping was performed to identify phase singularities (PSs). PSs were located in both atria, but we observed more PSs in the left atrium compared with the right atrium (779±302, 552±235; P =0.015). Although some PSs of duration sufficient to complete >1 rotation were detected, the maximum PS duration was only 1150 ms, and the vast majority (97%) of PSs persisted for too short a period to complete a full rotation. Although in selected patients there was evidence of PS local clustering, overall, PSs were distributed globally throughout both chambers with no clear anatomic predisposition. In a subset of patients (n=7), analysis was repeated using an alternative established atrial PS mapping technique, which confirmed our initial findings. No sustained rotors or localized drivers were detected, and instead, the mechanism of arrhythmia maintenance was consistent with the multiple wavelet hypothesis, with passive activation of short-lived rotational activity. URL: https://www.clinicaltrials.gov. Unique identifier: NCT01765075. © 2018 American Heart Association, Inc.

Identification of fecal input sites in spring water by selection and genotyping of multiresistant Escherichia coli.

PubMed

Wicki, Melanie; Karabulut, Fatma; Auckenthaler, Adrian; Felleisen, Richard; Tanner, Marcel; Baumgartner, Andreas

2011-12-01

The localization of fecal input sites is important for water quality management. For this purpose, we have developed a new approach based on a three-step procedure, including a preparatory phase, the screening of multiresistant bacteria using selective agar plates, and a typing phase where selected Escherichia coli isolates are characterized by antibiotic resistance profiles and molecular fingerprinting techniques (pulsed-field gel electrophoresis [PFGE]). These two well-known source tracking methods were combined in order to reduce cost and effort. This approach was successfully applied under field conditions in a study area located in the north-western part of Switzerland. E. coli isolates from spring water and surface water samples collected in this area were screened with selective agar plates. In this way, 21 different groups, each consisting of strains with the same pattern of antibiotic resistance, were found. Of these, four groups were further analyzed using PFGE. Strains with identical PFGE profiles were detected repeatedly, demonstrating the suitability of this method for the localization of fecal input sites over an extended period of time. Identical PFGE patterns of strains detected in water from two different springs were also found in the stream flowing through the study area. These results demonstrated the applicability of the new approach for the examination of incidents of fecal contamination in drinking water. The advantages of the described approach over genotyping methods currently being used to identify sources of fecal contaminants are a reduction in time, costs, and the effort required. Identical isolates could be identified without the construction of large libraries.

Pulsating aurora and cosmic noise absorption associated with growth-phase arcs

NASA Astrophysics Data System (ADS)

McKay, Derek; Partamies, Noora; Vierinen, Juha

2018-01-01

The initial stage of a magnetospheric substorm is the growth phase, which typically lasts 1-2 h. During the growth phase, an equatorward moving, east-west extended, optical auroral arc is observed. This is called a growth-phase arc. This work aims to characterize the optical emission and riometer absorption signatures associated with growth-phase arcs of isolated substorms. This is done using simultaneous all-sky camera and imaging riometer observations. The optical and riometric observations allow determination of the location of the precipitation within growth-phase arcs of low- (< 10 keV) and high- (> 10 keV) energy electrons, respectively. The observations indicate that growth-phase arcs have the following characteristics: 1. The peak of the cosmic noise absorption (CNA) arc is equatorward of the optical emission arc. This CNA is contained within the region of diffuse aurora on the equatorward side.2. Optical pulsating aurora are seen in the border region between the diffuse emission region on the equatorward side and the bright growth-phase arc on the poleward side. CNA is detected in the same region. 3. There is no evidence of pulsations in the CNA. 4. Once the equatorward drift starts, it proceeds at constant speed, with uniform separation between the growth-phase arc and CNA of 40 ± 10 km. Optical pulsating aurora are known to be prominent in the post-onset phase of a substorm. The fact that pulsations are also seen in a fairly localized region during the growth phase shows that the substorm expansion-phase dynamics are not required to closely precede the pulsating aurora.

Robust Vehicle Detection in Aerial Images Based on Cascaded Convolutional Neural Networks.

PubMed

Zhong, Jiandan; Lei, Tao; Yao, Guangle

2017-11-24

Vehicle detection in aerial images is an important and challenging task. Traditionally, many target detection models based on sliding-window fashion were developed and achieved acceptable performance, but these models are time-consuming in the detection phase. Recently, with the great success of convolutional neural networks (CNNs) in computer vision, many state-of-the-art detectors have been designed based on deep CNNs. However, these CNN-based detectors are inefficient when applied in aerial image data due to the fact that the existing CNN-based models struggle with small-size object detection and precise localization. To improve the detection accuracy without decreasing speed, we propose a CNN-based detection model combining two independent convolutional neural networks, where the first network is applied to generate a set of vehicle-like regions from multi-feature maps of different hierarchies and scales. Because the multi-feature maps combine the advantage of the deep and shallow convolutional layer, the first network performs well on locating the small targets in aerial image data. Then, the generated candidate regions are fed into the second network for feature extraction and decision making. Comprehensive experiments are conducted on the Vehicle Detection in Aerial Imagery (VEDAI) dataset and Munich vehicle dataset. The proposed cascaded detection model yields high performance, not only in detection accuracy but also in detection speed.

Robust Vehicle Detection in Aerial Images Based on Cascaded Convolutional Neural Networks

PubMed Central

Zhong, Jiandan; Lei, Tao; Yao, Guangle

2017-01-01

Vehicle detection in aerial images is an important and challenging task. Traditionally, many target detection models based on sliding-window fashion were developed and achieved acceptable performance, but these models are time-consuming in the detection phase. Recently, with the great success of convolutional neural networks (CNNs) in computer vision, many state-of-the-art detectors have been designed based on deep CNNs. However, these CNN-based detectors are inefficient when applied in aerial image data due to the fact that the existing CNN-based models struggle with small-size object detection and precise localization. To improve the detection accuracy without decreasing speed, we propose a CNN-based detection model combining two independent convolutional neural networks, where the first network is applied to generate a set of vehicle-like regions from multi-feature maps of different hierarchies and scales. Because the multi-feature maps combine the advantage of the deep and shallow convolutional layer, the first network performs well on locating the small targets in aerial image data. Then, the generated candidate regions are fed into the second network for feature extraction and decision making. Comprehensive experiments are conducted on the Vehicle Detection in Aerial Imagery (VEDAI) dataset and Munich vehicle dataset. The proposed cascaded detection model yields high performance, not only in detection accuracy but also in detection speed. PMID:29186756

Signal detectability in diffusive media using phased arrays in conjunction with detector arrays.

PubMed

Kang, Dongyel; Kupinski, Matthew A

2011-06-20

We investigate Hotelling observer performance (i.e., signal detectability) of a phased array system for tasks of detecting small inhomogeneities and distinguishing adjacent abnormalities in uniform diffusive media. Unlike conventional phased array systems where a single detector is located on the interface between two sources, we consider a detector array, such as a CCD, on a phantom exit surface for calculating the Hotelling observer detectability. The signal detectability for adjacent small abnormalities (2 mm displacement) for the CCD-based phased array is related to the resolution of reconstructed images. Simulations show that acquiring high-dimensional data from a detector array in a phased array system dramatically improves the detectability for both tasks when compared to conventional single detector measurements, especially at low modulation frequencies. It is also observed in all studied cases that there exists the modulation frequency optimizing CCD-based phased array systems, where detectability for both tasks is consistently high. These results imply that the CCD-based phased array has the potential to achieve high resolution and signal detectability in tomographic diffusive imaging while operating at a very low modulation frequency. The effect of other configuration parameters, such as a detector pixel size, on the observer performance is also discussed.

Phase congruency map driven brain tumour segmentation

NASA Astrophysics Data System (ADS)

Szilágyi, Tünde; Brady, Michael; Berényi, Ervin

2015-03-01

Computer Aided Diagnostic (CAD) systems are already of proven value in healthcare, especially for surgical planning, nevertheless much remains to be done. Gliomas are the most common brain tumours (70%) in adults, with a survival time of just 2-3 months if detected at WHO grades III or higher. Such tumours are extremely variable, necessitating multi-modal Magnetic Resonance Images (MRI). The use of Gadolinium-based contrast agents is only relevant at later stages of the disease where it highlights the enhancing rim of the tumour. Currently, there is no single accepted method that can be used as a reference. There are three main challenges with such images: to decide whether there is tumour present and is so localize it; to construct a mask that separates healthy and diseased tissue; and to differentiate between the tumour core and the surrounding oedema. This paper presents two contributions. First, we develop tumour seed selection based on multiscale multi-modal texture feature vectors. Second, we develop a method based on a local phase congruency based feature map to drive level-set segmentation. The segmentations achieved with our method are more accurate than previously presented methods, particularly for challenging low grade tumours.

MEMS ultrasonic transducer for monitoring of steel structures

NASA Astrophysics Data System (ADS)

Jain, Akash; Greve, David W.; Oppenheim, Irving J.

2002-06-01

Ultrasonic methods can be used to monitor crack propagation, weld failure, or section loss at critical locations in steel structures. However, ultrasonic inspection requires a skilled technician, and most commonly the signal obtained at any inspection is not preserved for later use. A preferred technology would use a MEMS device permanently installed at a critical location, polled remotely, and capable of on-chip signal processing using a signal history. We review questions related to wave geometry, signal levels, flaw localization, and electromechanical design issues for microscale transducers, and then describe the design, characterization, and initial testing of a MEMS transducer to function as a detector array. The device is approximately 1-cm square and was fabricated by the MUMPS process. The chip has 23 sensor elements to function in a phased array geometry, each element containing 180 hexagonal polysilicon diaphragms with a typical leg length of 49 microns and an unloaded natural frequency near 3.5 MHz. We first report characterization studies including capacitance-voltage measurements and admittance measurements, and then report initial experiments using a conventional piezoelectric transducer for excitation, with successful detection of signals in an on-axis transmission experiment and successful source localization from phased array performance in an off-axis transmission experiment.

Determination of N,N-dimethyltryptamine in Mimosa tenuiflora inner barks by matrix solid-phase dispersion procedure and GC-MS.

PubMed

Gaujac, Alain; Aquino, Adriano; Navickiene, Sandro; de Andrade, Jailson Bittencourt

2012-01-15

N,N-dimethyltryptamine (DMT) is a potent hallucinogen found in beverages consumed in religion rituals and neo-shamanic practices over the world. Two of these religions, Santo Daime and União do Vegetal (UDV), are represented in countries including Australia, the United States and several European nations. In some of this countries there have been legal disputes concerning the legalization of ayahuasca consumption during religious rituals, a beverage rich in DMT. In Brazil, even children and pregnant women are legally authorized to consume ayahuasca in a religious context. A simple and low-cost method based on matrix solid-phase dispersion (MSPD) and gas chromatography with mass spectrometric detection (GC-MS) has been optimized for the determination of N,N-dimethyltryptamine in Mimosa tenuiflora inner bark. The experimental variables that affect the MSPD method, such as the amounts of solid-phase and herbal sample, solvent nature, eluate volume and NaOH concentration were optimized using an experimental design. The method showed good linearity (r = 0.9962) and repeatability (RSD < 7.4%) for DMT compound, with detection limit of 0.12 mg/g. The proposed method was used to analyze 24 samples obtained locally. The results showed that concentrations of the target compound in M. tenuiflora barks, ranged from 1.26 to 9.35 mg/g for these samples. Copyright © 2011 Elsevier B.V. All rights reserved.

Phase I study of icotinib, an EGFR tyrosine kinase inhibitor combined with IMRT in nasopharyngeal carcinoma.

PubMed

Hu, Wei; Wang, Wei; Yang, Peinong; Zhou, Chao; Yang, Weifang; Wu, Bo; Lu, Hongsheng; Yang, Haihua

2015-01-01

Epidermal growth factor receptor (EGFR) is a new target for nasopharyngeal carcinoma (NPC) therapy. This prospective phase I study sought to determine the safety and recommended phase II dose of icotinib, a novel highly selective oral EGFR tyrosine kinase inhibitor, in combination with intensity-modulated radiotherapy (IMRT) in patients with NPC. Eligible patients with NPC received escalating doses of icotinib during IMRT. We treated six patients at a particular dose level until the maximum tolerated dose (MTD) was determined. The starting dose was 125 mg, once-daily and the dose was escalated to another level 125 mg, twice- and thrice- daily, until dose-limiting toxicity (DLT) occurred in two or more patients at a dose level. Expression and mutation analysis of EGFR were performed in all cases. A total of twelve patients were enrolled. Three patients experienced DLT (250 mg/day cohort) and MTD was 125 mg/day. Mucositis toxicity appears to be the major DLT. While EGFR expression in tumor tissue was detected in 75% (9/12) patients, EGFR mutation was detected in 16.67% (1/6) patients in 125 mg/day cohort, and 50% (3/6) in 250 mg/day cohort. The combination of icotinib (125 mg/day) and IMRT in patients with locally NPC had an acceptable safety profile and was well tolerated.

Detecting phase transitions in a neural network and its application to classification of syndromes in traditional Chinese medicine

NASA Astrophysics Data System (ADS)

Chen, J.; Xi, G.; Wang, W.

2008-02-01

Detecting phase transitions in neural networks (determined or random) presents a challenging subject for phase transitions play a key role in human brain activity. In this paper, we detect numerically phase transitions in two types of random neural network(RNN) under proper parameters.

Cdc6 localizes to S- and G2-phase centrosomes in a cell cycle-dependent manner

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Gwang Su; Kang, Jeeheon; Bang, Sung Woong

2015-01-16

Highlights: • Cdc6 protein is a component of the pre-replicative complex required for chromosomal replication initiation. • Cdc6 localized to centrosomes of S and G2 phases in a cell cycle-dependent manner. • The centrosomal localization was governed by centrosomal localization signal sequences of Cdc6. • Deletions or substitution mutations on the centrosomal localization signal interfered with centrosomal localization of the Cdc6 proteins. - Abstract: The Cdc6 protein has been primarily investigated as a component of the pre-replicative complex for the initiation of chromosome replication, which contributes to maintenance of chromosomal integrity. Here, we show that Cdc6 localized to the centrosomesmore » during S and G2 phases of the cell cycle. The centrosomal localization was mediated by Cdc6 amino acid residues 311–366, which are conserved within other Cdc6 homologues and contains a putative nuclear export signal. Deletions or substitutions of the amino acid residues did not allow the proteins to localize to centrosomes. In contrast, DsRed tag fused to the amino acid residues localized to centrosomes. These results indicated that a centrosome localization signal is contained within amino acid residues 311–366. The cell cycle-dependent centrosomal localization of Cdc6 in S and G2 phases suggest a novel function of Cdc6 in centrosomes.« less

Positive and negative ionospheric responses to the March 2015 geomagnetic storm from BDS observations

NASA Astrophysics Data System (ADS)

Jin, Shuanggen; Jin, Rui; Kutoglu, H.

2017-06-01

The most intense geomagnetic storm in solar cycle 24 occurred on March 17, 2015, and the detailed ionospheric storm morphologies are difficultly obtained from traditional observations. In this paper, the Geostationary Earth Orbit (GEO) observations of BeiDou Navigation Satellite System (BDS) are for the first time used to investigate the ionospheric responses to the geomagnetic storm. Using BDS GEO and GIMs TEC series, negative and positive responses to the March 2015 storm are found at local and global scales. During the main phase, positive ionospheric storm is the main response to the geomagnetic storm, while in the recovery phase, negative phases are pronounced at all latitudes. Maximum amplitudes of negative and positive phases appear in the afternoon and post-dusk sectors during both main and recovery phases. Furthermore, dual-peak positive phases in main phase and repeated negative phase during the recovery are found from BDS GEO observations. The geomagnetic latitudes corresponding to the maximum disturbances during the main and recovery phases show large differences, but they are quasi-symmetrical between southern and northern hemispheres. No clear zonal propagation of traveling ionospheric disturbances is detected in the GNSS TEC disturbances at high and low latitudes. The thermospheric composition variations could be the dominant source of the observed ionospheric storm effect from GUVI [O]/[N2] ratio data as well as storm-time electric fields. Our study demonstrates that the BDS (especially the GEO) observations are an important data source to observe ionospheric responses to the geomagnetic storm.

Latest Progress of Fault Detection and Localization in Complex Electrical Engineering

NASA Astrophysics Data System (ADS)

Zhao, Zheng; Wang, Can; Zhang, Yagang; Sun, Yi

2014-01-01

In the researches of complex electrical engineering, efficient fault detection and localization schemes are essential to quickly detect and locate faults so that appropriate and timely corrective mitigating and maintenance actions can be taken. In this paper, under the current measurement precision of PMU, we will put forward a new type of fault detection and localization technology based on fault factor feature extraction. Lots of simulating experiments indicate that, although there are disturbances of white Gaussian stochastic noise, based on fault factor feature extraction principal, the fault detection and localization results are still accurate and reliable, which also identifies that the fault detection and localization technology has strong anti-interference ability and great redundancy.

Structural Damage Detection with Piezoelectric Wafer Active Sensors

NASA Astrophysics Data System (ADS)

Giurgiutiu, Victor

2011-07-01

Piezoelectric wafer active sensors (PWAS) are lightweight and inexpensive enablers for a large class of damage detection and structural health monitoring (SHM) applications. This paper starts with a brief review of PWAS physical principles and basic modelling and continues by considering the various ways in which PWAS can be used for damage detection: (a) embedded guided-wave ultrasonics, i.e., pitch-catch, pulse-echo, phased arrays, thickness mode; (b) high-frequency modal sensing, i.e., the electro-mechanical (E/M) impedance method; (c) passive detection, i.e., acoustic emission and impact detection. An example of crack-like damage detection and localization with PWAS phased arrays on a small metallic plate is given. The modelling of PWAS detection of disbond damage in adhesive joints is achieved with the analytical transfer matrix method (TMM). The analytical methods offer the advantage of fast computation which enables parameter studies and carpet plots. A parametric study of the effect of crack size and PWAS location on disbond detection is presented. The power and energy transduction between PWAS and structure is studied analytically with a wave propagation method. Special attention is given to the mechatronics modeling of the complete transduction cycle from electrical excitation into ultrasonic acoustic waves by the piezoelectric effect, the transfer through the structure, and finally reverse piezoelectric transduction to generate the received electric signal. It is found that the combination of PWAS size and wave frequency/wavelength play an important role in identifying transduction maxima and minima that could be exploited to achieve an optimum power-efficient design. The multi-physics finite element method (MP-FEM), which permits fine discretization of damaged regions and complicated structural geometries, is used to study the generation of guided waves in a plate from an electrically excited transmitter PWAS and the capture of these waves as electric signals at a receiver PWAS. Wave diffraction from a hole damage is illustrated through time-frame snapshots. The paper ends with conclusions and suggestions for further work.

Robust snow avalanche detection using machine learning on infrasonic array data

NASA Astrophysics Data System (ADS)

Thüring, Thomas; Schoch, Marcel; van Herwijnen, Alec; Schweizer, Jürg

2014-05-01

Snow avalanches may threaten people and infrastructure in mountain areas. Automated detection of avalanche activity would be highly desirable, in particular during times of poor visibility, to improve hazard assessment, but also to monitor the effectiveness of avalanche control by explosives. In the past, a variety of remote sensing techniques and instruments for the automated detection of avalanche activity have been reported, which are based on radio waves (radar), seismic signals (geophone), optical signals (imaging sensor) or infrasonic signals (microphone). Optical imagery enables to assess avalanche activity with very high spatial resolution, however it is strongly weather dependent. Radar and geophone-based detection typically provide robust avalanche detection for all weather conditions, but are very limited in the size of the monitoring area. On the other hand, due to the long propagation distance of infrasound through air, the monitoring area of infrasonic sensors can cover a large territory using a single sensor (or an array). In addition, they are by far more cost effective than radars or optical imaging systems. Unfortunately, the reliability of infrasonic sensor systems has so far been rather low due to the strong variation of ambient noise (e.g. wind) causing a high false alarm rate. We analyzed the data collected by a low-cost infrasonic array system consisting of four sensors for the automated detection of avalanche activity at Lavin in the eastern Swiss Alps. A comparably large array aperture (~350m) allows highly accurate time delay estimations of signals which arrive at different times at the sensors, enabling precise source localization. An array of four sensors is sufficient for the time resolved source localization of signals in full 3D space, which is an excellent method to anticipate true avalanche activity. Robust avalanche detection is then achieved by using machine learning methods such as support vector machines. The system is initially trained by using characteristic data features from known avalanche and non-avalanche events. Data features are obtained from output signals of the source localization algorithm or from Fourier or time domain processing and support the learning phase of the system. A significantly improved detection rate as well as a reduction of the false alarm rate was achieved compared to previous approaches.

AC orbit bump method of local impedance measurement

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smaluk, Victor; Yang, Xi; Blednykh, Alexei

A fast and precise technique of local impedance measurement has been developed and tested at NSLS-II. This technique is based on in-phase sine-wave (AC) excitation of four fast correctors adjacent to the vacuum chamber section, impedance of which is measured. The beam position is measured using synchronous detection. Use of the narrow-band sine-wave signal allows us to improve significantly the accuracy of the orbit bump method. Beam excitation by fast correctors results in elimination of the systematic error caused by hysteresis effect. The systematic error caused by orbit drift is also eliminated because the measured signal is not affected bymore » the orbit motion outside the excitation frequency range. In this article, the measurement technique is described and the result of proof-of-principle experiment carried out at NSLS-II is presented.« less

RFMix: A Discriminative Modeling Approach for Rapid and Robust Local-Ancestry Inference

PubMed Central

Maples, Brian K.; Gravel, Simon; Kenny, Eimear E.; Bustamante, Carlos D.

2013-01-01

Local-ancestry inference is an important step in the genetic analysis of fully sequenced human genomes. Current methods can only detect continental-level ancestry (i.e., European versus African versus Asian) accurately even when using millions of markers. Here, we present RFMix, a powerful discriminative modeling approach that is faster (∼30×) and more accurate than existing methods. We accomplish this by using a conditional random field parameterized by random forests trained on reference panels. RFMix is capable of learning from the admixed samples themselves to boost performance and autocorrect phasing errors. RFMix shows high sensitivity and specificity in simulated Hispanics/Latinos and African Americans and admixed Europeans, Africans, and Asians. Finally, we demonstrate that African Americans in HapMap contain modest (but nonzero) levels of Native American ancestry (∼0.4%). PMID:23910464

AC orbit bump method of local impedance measurement

DOE PAGES

Smaluk, Victor; Yang, Xi; Blednykh, Alexei; ...

2017-08-04

A fast and precise technique of local impedance measurement has been developed and tested at NSLS-II. This technique is based on in-phase sine-wave (AC) excitation of four fast correctors adjacent to the vacuum chamber section, impedance of which is measured. The beam position is measured using synchronous detection. Use of the narrow-band sine-wave signal allows us to improve significantly the accuracy of the orbit bump method. Beam excitation by fast correctors results in elimination of the systematic error caused by hysteresis effect. The systematic error caused by orbit drift is also eliminated because the measured signal is not affected bymore » the orbit motion outside the excitation frequency range. In this article, the measurement technique is described and the result of proof-of-principle experiment carried out at NSLS-II is presented.« less

EEG oscillatory patterns are associated with error prediction during music performance and are altered in musician's dystonia.

PubMed

Ruiz, María Herrojo; Strübing, Felix; Jabusch, Hans-Christian; Altenmüller, Eckart

2011-04-15

Skilled performance requires the ability to monitor ongoing behavior, detect errors in advance and modify the performance accordingly. The acquisition of fast predictive mechanisms might be possible due to the extensive training characterizing expertise performance. Recent EEG studies on piano performance reported a negative event-related potential (ERP) triggered in the ACC 70 ms before performance errors (pitch errors due to incorrect keypress). This ERP component, termed pre-error related negativity (pre-ERN), was assumed to reflect processes of error detection in advance. However, some questions remained to be addressed: (i) Does the electrophysiological marker prior to errors reflect an error signal itself or is it related instead to the implementation of control mechanisms? (ii) Does the posterior frontomedial cortex (pFMC, including ACC) interact with other brain regions to implement control adjustments following motor prediction of an upcoming error? (iii) Can we gain insight into the electrophysiological correlates of error prediction and control by assessing the local neuronal synchronization and phase interaction among neuronal populations? (iv) Finally, are error detection and control mechanisms defective in pianists with musician's dystonia (MD), a focal task-specific dystonia resulting from dysfunction of the basal ganglia-thalamic-frontal circuits? Consequently, we investigated the EEG oscillatory and phase synchronization correlates of error detection and control during piano performances in healthy pianists and in a group of pianists with MD. In healthy pianists, the main outcomes were increased pre-error theta and beta band oscillations over the pFMC and 13-15 Hz phase synchronization, between the pFMC and the right lateral prefrontal cortex, which predicted corrective mechanisms. In MD patients, the pattern of phase synchronization appeared in a different frequency band (6-8 Hz) and correlated with the severity of the disorder. The present findings shed new light on the neural mechanisms, which might implement motor prediction by means of forward control processes, as they function in healthy pianists and in their altered form in patients with MD. Copyright © 2010 Elsevier Inc. All rights reserved.

Do breeding phase and detection distance influence the effective area surveyed for northern goshawks?

USGS Publications Warehouse

Roberson, A.M.; Andersen, D.E.; Kennedy, P.L.

2005-01-01

Broadcast surveys using conspecific calls are currently the most effective method for detecting northern goshawks (Accipiter gentilis) during the breeding season. These surveys typically use alarm calls during the nestling phase and juvenile food-begging calls during the fledgling-dependency phase. Because goshawks are most vocal during the courtship phase, we hypothesized that this phase would be an effective time to detect goshawks. Our objective was to improve current survey methodology by evaluating the probability of detecting goshawks at active nests in northern Minnesota in 3 breeding phases and at 4 broadcast distances and to determine the effective area surveyed per broadcast station. Unlike previous studies, we broadcast calls at only 1 distance per trial. This approach better quantifies (1) the relationship between distance and probability of detection, and (2) the effective area surveyed (EAS) per broadcast station. We conducted 99 broadcast trials at 14 active breeding areas. When pooled over all distances, detection rates were highest during the courtship (70%) and fledgling-dependency phases (68%). Detection rates were lowest during the nestling phase (28%), when there appeared to be higher variation in likelihood of detecting individuals. EAS per broadcast station was 39.8 ha during courtship and 24.8 ha during fledgling-dependency. Consequently, in northern Minnesota, broadcast stations may be spaced 712m and 562 m apart when conducting systematic surveys during courtship and fledgling-dependency, respectively. We could not calculate EAS for the nestling phase because probability of detection was not a simple function of distance from nest. Calculation of EAS could be applied to other areas where the probability of detection is a known function of distance.

Local characterization of one-dimensional topologically ordered states

NASA Astrophysics Data System (ADS)

Cui, Jian; Amico, Luigi; Fan, Heng; Gu, Mile; Hamma, Alioscia; Vedral, Vlatko

2013-09-01

We consider one-dimensional Hamiltonian systems whose ground states display symmetry-protected topological order. We show that ground states within the topological phase cannot be connected with each other through local operations and classical communication between a bipartition of the system. Our claim is demonstrated by analyzing the entanglement spectrum and Rényi entropies of different physical systems that provide examples for symmetry-protected topological phases. Specifically, we consider the spin-1/2 cluster-Ising model and a class of spin-1 models undergoing quantum phase transitions to the Haldane phase. Our results provide a probe for symmetry-protected topological order. Since the picture holds even at the system's local scale, our analysis can serve as a local experimental test for topological order.

A Linear Model of Phase-Dependent Power Correlations in Neuronal Oscillations

PubMed Central

Eriksson, David; Vicente, Raul; Schmidt, Kerstin

2011-01-01

Recently, it has been suggested that effective interactions between two neuronal populations are supported by the phase difference between the oscillations in these two populations, a hypothesis referred to as “communication through coherence” (CTC). Experimental work quantified effective interactions by means of the power correlations between the two populations, where power was calculated on the local field potential and/or multi-unit activity. Here, we present a linear model of interacting oscillators that accounts for the phase dependency of the power correlation between the two populations and that can be used as a reference for detecting non-linearities such as gain control. In the experimental analysis, trials were sorted according to the coupled phase difference of the oscillators while the putative interaction between oscillations was taking place. Taking advantage of the modeling, we further studied the dependency of the power correlation on the uncoupled phase difference, connection strength, and topology. Since the uncoupled phase difference, i.e., the phase relation before the effective interaction, is the causal variable in the CTC hypothesis we also describe how power correlations depend on that variable. For uni-directional connectivity we observe that the width of the uncoupled phase dependency is broader than for the coupled phase. Furthermore, the analytical results show that the characteristics of the phase dependency change when a bidirectional connection is assumed. The width of the phase dependency indicates which oscillation frequencies are optimal for a given connection delay distribution. We propose that a certain width enables a stimulus-contrast dependent extent of effective long-range lateral connections. PMID:21808618

The Development of Brazilian Municipalities Flooded by Hydropower Plants

NASA Astrophysics Data System (ADS)

Araujo, N.; Moretto, E. M.; Roquetti, D. R.; Beduschi, L. C.; Praia, A.; Pulice, S.; Albiach, E.; Athayde, S.

2016-12-01

Hydropower plants cause negative environmental impacts during the phases of construction and operation. On the other hand, there is a general assumption that these projects also induce local development of the affected places, since there is a great influx of social and financial capital brought locally, especially during the construction phase the relationship between hydropower plant implementation s and local development has been controversial in the Environmental Impact Assessment field, and there is no empirical evidence showing how hydroelectric dam construction affects local development. Considering municipal development as a kind of local development and operationalizing the concept of human development by adopting income, longevity and education dimensions defined by Amartya Sen, this study aimed to verify empirical evidences regarding the role of hydropower plants in human development of their flooded municipalities in Brazil. For this, we considered 134 hydroelectric plants and correspondent 641 flooded municipalities, for which 155 human development indicators were obtained for the period of 2000 to 2010. Results obtained from statistical correlation analysis and their assumption tests showed that increases in the municipal flooded area and increases in the period of flooding - to which a given municipality is submitted - were associated with lower performances of human development indicators. Specifically, increases in social inequality, poverty and lower performances of longevity and education were detected for the flooded municipalities. We also found that the financial compensation was associated with better performance of municipal income and lower performances of education and longevity. Finally, approaching the growth poles theory of François Perroux and the productive linkages theory of Albert Hirschman, we suggest that the size of the flooded areas, the flooding period and the financial compensation may lead to an enclave situation in municipalities flooded by hydropower plants, considering issues of education and longevity. Furthermore, it is likely that the labor force, investments and financial compensation inputs brought by these projects to the local municipalities are not strong enough to reverse this enclave scenario.

Using large volume samplers for the monitoring of particle bound micro pollutants in rivers

NASA Astrophysics Data System (ADS)

Kittlaus, Steffen; Fuchs, Stephan

2015-04-01

The requirements of the WFD as well as substance emission modelling at the river basin scale require stable monitoring data for micro pollutants. The monitoring concepts applied by the local authorities as well as by many scientists use single sampling techniques. Samples from water bodies are usually taken in volumes of about one litre and depending on predetermined time steps or through discharge thresholds. For predominantly particle bound micro pollutants the small sample size of about one litre results in a very small amount of suspended particles. To measure micro pollutant concentrations in these samples is demanding and results in a high uncertainty of the measured concentrations, if the concentration is above the detection limit in the first place. In many monitoring programs most of the measured values were below the detection limit. This results in a high uncertainty if river loads were calculated from these data sets. The authors propose a different approach to gain stable concentration values for particle bound micro pollutants from river monitoring: A mixed sample of about 1000 L was pumped in a tank with a dirty-water pump. The sampling usually is done discharge dependant by using a gauge signal as input for the control unit. After the discharge event is over or the tank is fully filled, the suspended solids settle in the tank for 2 days. After this time a clear separation of water and solids can be shown. A sample (1 L) from the water phase and the total mass of the settled solids (about 10 L) are taken to the laboratory for analysis. While the micro pollutants can't hardly be detected in the water phase, the signal from the sediment is high above the detection limit, thus certain and very stable. From the pollutant concentration in the solid phase and the total tank volume the initial pollutant concentration in the sample can be calculated. If the concentration in the water phase is detectable, it can be used to correct the total load. This relatively low cost approach (less costs for analysis because of small sample number) allows to quantify the pollutant load, to derive dissolved-solid partition coefficients and to quantify the pollutant load in different particle size classes.

Segmentation Approach Towards Phase-Contrast Microscopic Images of Activated Sludge to Monitor the Wastewater Treatment.

PubMed

Khan, Muhammad Burhan; Nisar, Humaira; Ng, Choon Aun; Yeap, Kim Ho; Lai, Koon Chun

2017-12-01

Image processing and analysis is an effective tool for monitoring and fault diagnosis of activated sludge (AS) wastewater treatment plants. The AS image comprise of flocs (microbial aggregates) and filamentous bacteria. In this paper, nine different approaches are proposed for image segmentation of phase-contrast microscopic (PCM) images of AS samples. The proposed strategies are assessed for their effectiveness from the perspective of microscopic artifacts associated with PCM. The first approach uses an algorithm that is based on the idea that different color space representation of images other than red-green-blue may have better contrast. The second uses an edge detection approach. The third strategy, employs a clustering algorithm for the segmentation and the fourth applies local adaptive thresholding. The fifth technique is based on texture-based segmentation and the sixth uses watershed algorithm. The seventh adopts a split-and-merge approach. The eighth employs Kittler's thresholding. Finally, the ninth uses a top-hat and bottom-hat filtering-based technique. The approaches are assessed, and analyzed critically with reference to the artifacts of PCM. Gold approximations of ground truth images are prepared to assess the segmentations. Overall, the edge detection-based approach exhibits the best results in terms of accuracy, and the texture-based algorithm in terms of false negative ratio. The respective scenarios are explained for suitability of edge detection and texture-based algorithms.

DETECTING EXOMOONS AROUND SELF-LUMINOUS GIANT EXOPLANETS THROUGH POLARIZATION.

PubMed

Sengupta, Sujan; Marley, Mark S

2016-01-01

Many of the directly imaged self-luminous gas giant exoplanets have been found to have cloudy atmospheres. Scattering of the emergent thermal radiation from these planets by the dust grains in their atmospheres should locally give rise to significant linear polarization of the emitted radiation. However, the observable disk averaged polarization should be zero if the planet is spherically symmetric. Rotation-induced oblateness may yield a net non-zero disk averaged polarization if the planets have sufficiently high spin rotation velocity. On the other hand, when a large natural satellite or exomoon transits a planet with cloudy atmosphere along the line of sight, the asymmetry induced during the transit should give rise to a net non-zero, time resolved linear polarization signal. The peak amplitude of such time dependent polarization may be detectable even for slowly rotating exoplanets. Therefore, we suggest that large exomoons around directly imaged self-luminous exoplanets may be detectable through time resolved imaging polarimetry. Adopting detailed atmospheric models for several values of effective temperature and surface gravity which are appropriate for self-luminous exoplanets, we present the polarization profiles of these objects in the infrared during transit phase and estimate the peak amplitude of polarization that occurs during the inner contacts of the transit ingress/egress phase. The peak polarization is predicted to range between 0.1 and 0.3 % in the infrared.

DETECTING EXOMOONS AROUND SELF-LUMINOUS GIANT EXOPLANETS THROUGH POLARIZATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sengupta, Sujan; Marley, Mark S., E-mail: sujan@iiap.res.in, E-mail: Mark.S.Marley@NASA.gov

Many of the directly imaged self-luminous gas-giant exoplanets have been found to have cloudy atmospheres. Scattering of the emergent thermal radiation from these planets by the dust grains in their atmospheres should locally give rise to significant linear polarization of the emitted radiation. However, the observable disk-averaged polarization should be zero if the planet is spherically symmetric. Rotation-induced oblateness may yield a net non-zero disk-averaged polarization if the planets have sufficiently high spin rotation velocity. On the other hand, when a large natural satellite or exomoon transits a planet with a cloudy atmosphere along the line of sight, the asymmetrymore » induced during the transit should give rise to a net non-zero, time-resolved linear polarization signal. The peak amplitude of such time-dependent polarization may be detectable even for slowly rotating exoplanets. Therefore, we suggest that large exomoons around directly imaged self-luminous exoplanets may be detectable through time-resolved imaging polarimetry. Adopting detailed atmospheric models for several values of effective temperature and surface gravity that are appropriate for self-luminous exoplanets, we present the polarization profiles of these objects in the infrared during the transit phase and estimate the peak amplitude of polarization that occurs during the inner contacts of the transit ingress/egress phase. The peak polarization is predicted to range between 0.1% and 0.3% in the infrared.« less

Detecting Exomoons Around Self-Luminous Giant Exoplanets Through Polarization

NASA Technical Reports Server (NTRS)

Sengupta, Sujan; Marley, Mark Scott

2016-01-01

Many of the directly imaged self-luminous gas giant exoplanets have been found to have cloudy atmo- spheres. Scattering of the emergent thermal radiation from these planets by the dust grains in their atmospheres should locally give rise to significant linear polarization of the emitted radiation. However, the observable disk averaged polarization should be zero if the planet is spherically symmetric. Rotation-induced oblateness may yield a net non-zero disk averaged polarization if the planets have sufficiently high spin rotation velocity. On the other hand, when a large natural satellite or exomoon transits a planet with cloudy atmosphere along the line of sight, the asymmetry induced during the transit should give rise to a net non-zero, time resolved linear polarization signal. The peak amplitude of such time dependent polarization may be detectable even for slowly rotating exoplanets. Therefore, we suggest that large exomoons around directly imaged self-luminous exoplanets may be detectable through time resolved imaging polarimetry. Adopting detailed atmospheric models for several values of effective temperature and surface gravity which are appropriate for self-luminous exoplanets, we present the polarization profiles of these objects in the infrared during transit phase and estimate the peak amplitude of polarization that occurs during the the inner contacts of the transit ingress/egress phase. The peak polarization is predicted to range between 0.1 and 0.3 % in the infrared.

DETECTING EXOMOONS AROUND SELF-LUMINOUS GIANT EXOPLANETS THROUGH POLARIZATION

PubMed Central

Sengupta, Sujan; Marley, Mark S.

2017-01-01

Many of the directly imaged self-luminous gas giant exoplanets have been found to have cloudy atmospheres. Scattering of the emergent thermal radiation from these planets by the dust grains in their atmospheres should locally give rise to significant linear polarization of the emitted radiation. However, the observable disk averaged polarization should be zero if the planet is spherically symmetric. Rotation-induced oblateness may yield a net non-zero disk averaged polarization if the planets have sufficiently high spin rotation velocity. On the other hand, when a large natural satellite or exomoon transits a planet with cloudy atmosphere along the line of sight, the asymmetry induced during the transit should give rise to a net non-zero, time resolved linear polarization signal. The peak amplitude of such time dependent polarization may be detectable even for slowly rotating exoplanets. Therefore, we suggest that large exomoons around directly imaged self-luminous exoplanets may be detectable through time resolved imaging polarimetry. Adopting detailed atmospheric models for several values of effective temperature and surface gravity which are appropriate for self-luminous exoplanets, we present the polarization profiles of these objects in the infrared during transit phase and estimate the peak amplitude of polarization that occurs during the inner contacts of the transit ingress/egress phase. The peak polarization is predicted to range between 0.1 and 0.3 % in the infrared. PMID:29430024

Laboratory Investigation of Trace Gas Emissions from Biomass Burning on DoD Bases

NASA Astrophysics Data System (ADS)

Burling, I. R.; Yokelson, R. J.; Griffith, D. W.; Roberts, J. M.; Veres, P. R.; Warneke, C.; Johnson, T. J.

2009-12-01

Vegetation representing fuels commonly managed with prescribed fires was collected from five DoD bases and burned under controlled conditions at the USFS Firelab in Missoula, MT. The smoke emissions were measured with a large suite of state-of-the-art instrumentation. Seventy-seven fires were conducted and the smoke composition data will improve DoD land managers’ ability to assess the impact of prescribed fires on local air quality. A key instrument used in the measurement of the gas phase species in smoke was an open-path FTIR (OP-FTIR) spectrometer, built and operated by the Universities of Montana and Wollongong. The OP-FTIR has to date detected and quantified 20 gas phase species - CO2, CO, H2O, N2O, NO2, NO, HONO, NH3, HCl, SO2, CH4, CH3OH, HCHO, HCOOH, C2H2, C2H4, CH3COOH, HCN, propylene and furan. The spectra were analyzed using a non-linear least squares fitting routine that included reference spectra recently acquired at the Pacific Northwest National Laboratories. Preliminary results from the OP-FTIR analysis are reported here. Of particular interest, gas-phase nitrous acid (HONO) was detected simultaneously by the OP-FTIR and negative-ion proton-transfer chemical ionization spectrometer (NI-PT-CIMS), with preliminary fire-integrated molar emission ratios (relative to NOx) ranging from approximately 0.03 to 0.20, depending on the vegetation type. HONO is an important precursor in the production of OH, the primary oxidizing species in the atmosphere. There existed little previous data documenting HONO emissions from either wild or prescribed fires. The non-methane organic emissions were dominated by oxygenated species, which can be further oxidized and thus involved in secondary aerosol formation. Elevated amounts of gas-phase HCl were also detected in the smoke, with the amounts varying depending on location and vegetation type.

Temporal evolution of the spin-wave intensity and phase in a local parametric amplifier

NASA Astrophysics Data System (ADS)

Brächer, T.; Heussner, F.; Meyer, T.; Fischer, T.; Geilen, M.; Heinz, B.; Lägel, B.; Hillebrands, B.; Pirro, P.

2018-03-01

We present a time-resolved study of the evolution of the spin-wave intensity and phase in a local parametric spin-wave amplifier at pumping powers close to the threshold of parametric generation. We show that the phase of the amplified spin waves is determined by the phase of the incoming signal-carrying spin waves and that it can be preserved on long time scales as long as the energy input by the input spin waves is provided. In contrast, the phase-information is lost in such a local spin-wave amplifier as soon as the input spin-wave is switched off. These findings are an important benchmark for the use of parametric amplifiers in logic circuits relying on the spin-wave phase as information carrier.

Characterizing the correlations between local phase fractions of gas-liquid two-phase flow with wire-mesh sensor.

PubMed

Tan, C; Liu, W L; Dong, F

2016-06-28

Understanding of flow patterns and their transitions is significant to uncover the flow mechanics of two-phase flow. The local phase distribution and its fluctuations contain rich information regarding the flow structures. A wire-mesh sensor (WMS) was used to study the local phase fluctuations of horizontal gas-liquid two-phase flow, which was verified through comparing the reconstructed three-dimensional flow structure with photographs taken during the experiments. Each crossing point of the WMS is treated as a node, so the measurement on each node is the phase fraction in this local area. An undirected and unweighted flow pattern network was established based on connections that are formed by cross-correlating the time series of each node under different flow patterns. The structure of the flow pattern network reveals the relationship of the phase fluctuations at each node during flow pattern transition, which is then quantified by introducing the topological index of the complex network. The proposed analysis method using the WMS not only provides three-dimensional visualizations of the gas-liquid two-phase flow, but is also a thorough analysis for the structure of flow patterns and the characteristics of flow pattern transition. This article is part of the themed issue 'Supersensing through industrial process tomography'. © 2016 The Author(s).

Characterizing the correlations between local phase fractions of gas–liquid two-phase flow with wire-mesh sensor

PubMed Central

Liu, W. L.; Dong, F.

2016-01-01

Understanding of flow patterns and their transitions is significant to uncover the flow mechanics of two-phase flow. The local phase distribution and its fluctuations contain rich information regarding the flow structures. A wire-mesh sensor (WMS) was used to study the local phase fluctuations of horizontal gas–liquid two-phase flow, which was verified through comparing the reconstructed three-dimensional flow structure with photographs taken during the experiments. Each crossing point of the WMS is treated as a node, so the measurement on each node is the phase fraction in this local area. An undirected and unweighted flow pattern network was established based on connections that are formed by cross-correlating the time series of each node under different flow patterns. The structure of the flow pattern network reveals the relationship of the phase fluctuations at each node during flow pattern transition, which is then quantified by introducing the topological index of the complex network. The proposed analysis method using the WMS not only provides three-dimensional visualizations of the gas–liquid two-phase flow, but is also a thorough analysis for the structure of flow patterns and the characteristics of flow pattern transition. This article is part of the themed issue ‘Supersensing through industrial process tomography’. PMID:27185959

A Dual Frequency Carrier Phase Error Difference Checking Algorithm for the GNSS Compass.

PubMed

Liu, Shuo; Zhang, Lei; Li, Jian

2016-11-24

The performance of the Global Navigation Satellite System (GNSS) compass is related to the quality of carrier phase measurement. How to process the carrier phase error properly is important to improve the GNSS compass accuracy. In this work, we propose a dual frequency carrier phase error difference checking algorithm for the GNSS compass. The algorithm aims at eliminating large carrier phase error in dual frequency double differenced carrier phase measurement according to the error difference between two frequencies. The advantage of the proposed algorithm is that it does not need additional environment information and has a good performance on multiple large errors compared with previous research. The core of the proposed algorithm is removing the geographical distance from the dual frequency carrier phase measurement, then the carrier phase error is separated and detectable. We generate the Double Differenced Geometry-Free (DDGF) measurement according to the characteristic that the different frequency carrier phase measurements contain the same geometrical distance. Then, we propose the DDGF detection to detect the large carrier phase error difference between two frequencies. The theoretical performance of the proposed DDGF detection is analyzed. An open sky test, a manmade multipath test and an urban vehicle test were carried out to evaluate the performance of the proposed algorithm. The result shows that the proposed DDGF detection is able to detect large error in dual frequency carrier phase measurement by checking the error difference between two frequencies. After the DDGF detection, the accuracy of the baseline vector is improved in the GNSS compass.

Lane Marking Detection and Reconstruction with Line-Scan Imaging Data.

PubMed

Li, Lin; Luo, Wenting; Wang, Kelvin C P

2018-05-20

A bstract: Lane marking detection and localization are crucial for autonomous driving and lane-based pavement surveys. Numerous studies have been done to detect and locate lane markings with the purpose of advanced driver assistance systems, in which image data are usually captured by vision-based cameras. However, a limited number of studies have been done to identify lane markings using high-resolution laser images for road condition evaluation. In this study, the laser images are acquired with a digital highway data vehicle (DHDV). Subsequently, a novel methodology is presented for the automated lane marking identification and reconstruction, and is implemented in four phases: (1) binarization of the laser images with a new threshold method (multi-box segmentation based threshold method); (2) determination of candidate lane markings with closing operations and a marching square algorithm; (3) identification of true lane marking by eliminating false positives (FPs) using a linear support vector machine method; and (4) reconstruction of the damaged and dash lane marking segments to form a continuous lane marking based on the geometry features such as adjacent lane marking location and lane width. Finally, a case study is given to validate effects of the novel methodology. The findings indicate the new strategy is robust in image binarization and lane marking localization. This study would be beneficial in road lane-based pavement condition evaluation such as lane-based rutting measurement and crack classification.

The use of echocardiography in Wolff-Parkinson-White syndrome.

PubMed

Cai, Qiangjun; Shuraih, Mossaab; Nagueh, Sherif F

2012-04-01

Endocardial mapping and radiofrequency catheter ablation are well established modalities for the diagnosis and treatment of patients with Wolff-Parkinson-White (WPW) syndrome associated with tachyarrhythmias. However, the electrophysiologic techniques are invasive, require radiation exposure, and lack spatial resolution of cardiac structures. A variety of echocardiographic techniques have been investigated as a non-invasive alternative for accessory pathway localization. Conventional M-mode echocardiography can detect the fine premature wall motion abnormalities associated with WPW syndrome. However, it is unable to identify the exact site of accessory pathway with sufficient accuracy. 2D, 2D-guided M-mode, and 2D phase analysis techniques are limited by image quality and endocardial border definition. Various modalities of tissue Doppler echocardiography significantly increase the accuracy of left-sided accessory pathway localization to 80-90% even in patients with poor acoustic window. However, right-sided pathways remain a diagnostic challenge. Strain echocardiography by speckle tracking has recently been evaluated and appears promising. Different cardiac abnormalities have been detected by echocardiography in WPW patients. Patients with WPW syndrome and tachyarrhythmias have impaired systolic and diastolic function which improves after radiofrequency ablation. Echocardiography is useful in identifying patient with accessory pathway-associated left ventricular dyssynchrony and dysfunction who may benefit from ablation therapy. Transesophageal and intracardiac echocardiography have been used to guide ablation procedure. Ablation-related complications detected by routine echocardiography are infrequent, rarely clinically relevant, and of limited value.

Profile parameters of wheelset detection for high speed freight train

NASA Astrophysics Data System (ADS)

Yang, Kai; Ma, Li; Gao, Xiaorong; Wang, Li

2012-04-01

Because of freight train, in China, transports goods on railway freight line throughout the country, it does not depart from or return to engine shed during a long phase, thus we cannot monitor the quality of wheel set effectively. This paper provides a system which uses leaser and high speed camera, applies no-contact light section technology to get precise wheel set profile parameters. The paper employs clamping-track method to avoid complex railway ballast modification project. And detailed descript an improved image-tracking algorithm to extract central line from profile curve. For getting one pixel width and continuous line of the profile curve, uses local gray maximum points as direction control points to direct tracking direction. The results based on practical experiment show the system adapted to detection environment of high speed and high vibration, and it can effectively detect the wheelset geometric parameters with high accuracy. The system fills the gaps in wheel set detection for freight train in main line and has an enlightening function on monitoring the quality of wheel set.

EnKF with closed-eye period - bridging intermittent model structural errors in soil hydrology

NASA Astrophysics Data System (ADS)

Bauser, Hannes H.; Jaumann, Stefan; Berg, Daniel; Roth, Kurt

2017-04-01

The representation of soil water movement exposes uncertainties in all model components, namely dynamics, forcing, subscale physics and the state itself. Especially model structural errors in the description of the dynamics are difficult to represent and can lead to an inconsistent estimation of the other components. We address the challenge of a consistent aggregation of information for a manageable specific hydraulic situation: a 1D soil profile with TDR-measured water contents during a time period of less than 2 months. We assess the uncertainties for this situation and detect initial condition, soil hydraulic parameters, small-scale heterogeneity, upper boundary condition, and (during rain events) the local equilibrium assumption by the Richards equation as the most important ones. We employ an iterative Ensemble Kalman Filter (EnKF) with an augmented state. Based on a single rain event, we are able to reduce all uncertainties directly, except for the intermittent violation of the local equilibrium assumption. We detect these times by analyzing the temporal evolution of estimated parameters. By introducing a closed-eye period - during which we do not estimate parameters, but only guide the state based on measurements - we can bridge these times. The introduced closed-eye period ensured constant parameters, suggesting that they resemble the believed true material properties. The closed-eye period improves predictions during periods when the local equilibrium assumption is met, but consequently worsens predictions when the assumption is violated. Such a prediction requires a description of the dynamics during local non-equilibrium phases, which remains an open challenge.

Iron meteorite fragment studied by atomic and nuclear analytical methods

NASA Astrophysics Data System (ADS)

Cesnek, Martin; Štefánik, Milan; Kmječ, Tomáš; Miglierini, Marcel

2016-10-01

Chemical and structural compositions of a fragment of Sikhote-Alin iron meteorite were investigated by X-ray fluorescence analysis (XRF), neutron activation analysis (NAA) and Mössbauer spectroscopy (MS). XRF and NAA revealed the presence of chemical elements which are characteristic for iron meteorites. XRF also showed a significant amount of Si and Al on the surface of the fragment. MS spectra revealed possible presence of α-Fe(Ni, Co) phase with different local Ni concentration. Furthermore, paramagnetic singlet was detected in Mössbauer spectra recorded at room temperature and at 4.2 K.

Two-path plasmonic interferometer with integrated detector

DOEpatents

Dyer, Gregory Conrad; Shaner, Eric A.; Aizin, Gregory

2016-03-29

An electrically tunable terahertz two-path plasmonic interferometer with an integrated detection element can down convert a terahertz field to a rectified DC signal. The integrated detector utilizes a resonant plasmonic homodyne mixing mechanism that measures the component of the plasma waves in-phase with an excitation field that functions as the local oscillator in the mixer. The plasmonic interferometer comprises two independently tuned electrical paths. The plasmonic interferometer enables a spectrometer-on-a-chip where the tuning of electrical path length plays an analogous role to that of physical path length in macroscopic Fourier transform interferometers.

Regulation and spatial organization of PCNA in Trypanosoma brucei

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kaufmann, Doris; Gassen, Alwine; Maiser, Andreas

2012-03-23

Highlights: Black-Right-Pointing-Pointer Characterization of the proliferating cell nuclear antigen in Trypanosoma brucei (TbPCNA). Black-Right-Pointing-Pointer TbPCNA is a suitable marker to detect replication in T. brucei. Black-Right-Pointing-Pointer TbPCNA distribution and regulation is different compared to closely related parasites T. cruzi and Leishmania donovani. -- Abstract: As in most eukaryotic cells, replication is regulated by a conserved group of proteins in the early-diverged parasite Trypanosoma brucei. Only a few components of the replication machinery have been described in this parasite and regulation, sub-nuclear localization and timing of replication are not well understood. We characterized the proliferating cell nuclear antigen in T. bruceimore » (TbPCNA) to establish a spatial and temporal marker for replication. Interestingly, PCNA distribution and regulation is different compared to the closely related parasites Trypanosoma cruzi and Leishmania donovani. TbPCNA foci are clearly detectable during S phase of the cell cycle but in contrast to T. cruzi they are not preferentially located at the nuclear periphery. Furthermore, PCNA seems to be degraded when cells enter G2 phase in T. brucei suggesting different modes of replication regulation or functions of PCNA in these closely related eukaryotes.« less

Structural health monitoring for DOT using magnetic shape memory alloy cables in concrete

NASA Astrophysics Data System (ADS)

Davis, Allen; Mirsayar, Mirmilad; Sheahan, Emery; Hartl, Darren

2018-03-01

Embedding shape memory alloy (SMA) wires in concrete components offers the potential to monitor their structural health via external magnetic field sensing. Currently, structural health monitoring (SHM) is dominated by acoustic emission and vibration-based methods. Thus, it is attractive to pursue alternative damage sensing techniques that may lower the cost or increase the accuracy of SHM. In this work, SHM via magnetic field detection applied to embedded magnetic shape memory alloy (MSMA) is demonstrated both experimentally and using computational models. A concrete beam containing iron-based MSMA wire is subjected to a 3-point bend test where structural damage is induced, thereby resulting in a localized phase change of the MSMA wire. Magnetic field lines passing through the embedded MSMA domain are altered by this phase change and can thus be used to detect damage within the structure. A good correlation is observed between the computational and experimental results. Additionally, the implementation of stranded MSMA cables in place of the MSMA wire is assessed through similar computational models. The combination of these computational models and their subsequent experimental validation provide sufficient support for the feasibility of SHM using magnetic field sensing via MSMA embedded components.

Graphene oxide bonded fused-silica fiber for solid-phase microextraction-gas chromatography of polycyclic aromatic hydrocarbons in water.

PubMed

Xu, Lili; Feng, Juanjuan; Li, Jubai; Liu, Xia; Jiang, Shengxiang

2012-01-01

A novel chemically bonded graphene oxide/fused-silica fiber was prepared and applied in solid-phase microextraction of six polycyclic aromatic hydrocarbons from water samples coupled with gas chromatography. It exhibited high extraction efficiency and excellent stability. Effects of extraction time, extraction temperature, ionic strength, stirring rate and desorption conditions were investigated and optimized in our work. Detection limits to the six polycyclic aromatic hydrocarbons were less than 0.08 μg/L, and their calibration curves were all linear (R(2)≥0.9954) in the range from 0.05 to 200 μg/L. Single fiber repeatability and fiber-to-fiber reproducibility were less than 6.13 and 15.87%, respectively. This novel fiber was then utilized to analyze two real water samples from the Yellow River and local waterworks, and the recoveries of samples spiked at 1 and 10 μg/L ranged from 84.48 to 118.24%. Compared with other coating materials, this graphene oxide-coated fiber showed many advantages: wide linear range, low detection limit, and good stability in acid, alkali, organic solutions and at high temperature. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Fault detection and diagnosis in a spacecraft attitude determination system

NASA Astrophysics Data System (ADS)

Pirmoradi, F. N.; Sassani, F.; de Silva, C. W.

2009-09-01

This paper presents a new scheme for fault detection and diagnosis (FDD) in spacecraft attitude determination (AD) sensors. An integrated attitude determination system, which includes measurements of rate and angular position using rate gyros and vector sensors, is developed. Measurement data from all sensors are fused by a linearized Kalman filter, which is designed based on the system kinematics, to provide attitude estimation and the values of the gyro bias. Using this information the erroneous sensor measurements are corrected, and unbounded sensor measurement errors are avoided. The resulting bias-free data are used in the FDD scheme. The FDD algorithm uses model-based state estimation, combining the information from the rotational dynamics and kinematics of a spacecraft with the sensor measurements to predict the future sensor outputs. Fault isolation is performed through extended Kalman filters (EKFs). The innovation sequences of EKFs are monitored by several statistical tests to detect the presence of a failure and to localize the failures in all AD sensors. The isolation procedure is developed in two phases. In the first phase, two EKFs are designed, which use subsets of measurements to provide state estimates and form residuals, which are used to verify the source of the fault. In the second phase of isolation, testing of multiple hypotheses is performed. The generalized likelihood ratio test is utilized to identify the faulty components. In the scheme developed in this paper a relatively small number of hypotheses is used, which results in faster isolation and highly distinguishable fault signatures. An important feature of the developed FDD scheme is that it can provide attitude estimations even if only one type of sensors is functioning properly.

Distributed fiber optic intrusion sensor system for monitoring long perimeters

NASA Astrophysics Data System (ADS)

Juarez, Juan C.; Taylor, Henry F.

2005-05-01

The use of an optical fiber as a distributed sensor for detecting and locating intruders over long perimeters (>10 km) is described. Phase changes resulting from either the pressure of the intruder on the ground immediately above the buried fiber or from seismic disturbances in the vicinity are sensed by a phase-sensitive optical time-domain reflectometer (Φ-OTDR). Light pulses from a cw laser operating in a single longitudinal mode and with low (MHz/min range) frequency drift are injected into one end of the single mode fiber, and the backscattered light is monitored with a photodetector. In laboratory tests with 12 km of fiber on reels, the effects of localized phase perturbations induced by a piezoelectric fiber stretcher on Φ-OTDR traces were characterized. In field tests in which the sensing element is a single mode fiber in a 3-mm diameter cable buried in a 20-46 cm deep, 10 cm wide trench in clay soil, detection of intruders on foot up to 4.6 m from the cable line was achieved. In desert terrain field tests in which the sensing fiber is in a 4.5-mm diameter cable buried in a 30 cm deep, 75 cm wide trench filled with loose sand, high sensitivity and consistent detection of intruders on foot and of vehicles traveling down a road near the cable line was realized over a cable length of 8.5 km and a total fiber path of 19 km. Based on these results, this technology may be regarded as a candidate for providing low-cost perimeter security for nuclear power plants, electrical power distribution centers, storage facilities for fuel and volatile chemicals, communication hubs, airports, government offices, military bases, embassies, and national borders.

Quantum phases with differing computational power.

PubMed

Cui, Jian; Gu, Mile; Kwek, Leong Chuan; Santos, Marcelo França; Fan, Heng; Vedral, Vlatko

2012-05-01

The observation that concepts from quantum information has generated many alternative indicators of quantum phase transitions hints that quantum phase transitions possess operational significance with respect to the processing of quantum information. Yet, studies on whether such transitions lead to quantum phases that differ in their capacity to process information remain limited. Here we show that there exist quantum phase transitions that cause a distinct qualitative change in our ability to simulate certain quantum systems under perturbation of an external field by local operations and classical communication. In particular, we show that in certain quantum phases of the XY model, adiabatic perturbations of the external magnetic field can be simulated by local spin operations, whereas the resulting effect within other phases results in coherent non-local interactions. We discuss the potential implications to adiabatic quantum computation, where a computational advantage exists only when adiabatic perturbation results in coherent multi-body interactions.

Local Orthorhombicity in the Magnetic C 4 Phase of the Hole-Doped Iron-Arsenide Superconductor Sr 1 - x Na x Fe 2 As 2

DOE PAGES

Frandsen, Benjamin A.; Taddei, Keith M.; Yi, Ming; ...

2017-10-30

We report on temperature-dependent pair distribution function measurements of Sr 1-xNa xFe 2As 2, an iron-based superconductor system that contains a magnetic phase with reentrant tetragonal symmetry, known as the magnetic C 4 phase. Quantitative refinements indicate that the instantaneous local structure in the C 4 phase comprises fluctuating orthorhombic regions with a length scale of similar to 2 nm, despite the tetragonal symmetry of the average static structure. Additionally, local orthorhombic fluctuations exist on a similar length scale at temperatures well into the paramagnetic tetragonal phase. Furthermore, these results highlight the exceptionally large nematic susceptibility of iron-based superconductors andmore » have significant implications for the magnetic C 4 phase and the neighboring C 2 and superconducting phases.« less

Local Orthorhombicity in the Magnetic C 4 Phase of the Hole-Doped Iron-Arsenide Superconductor Sr 1 - x Na x Fe 2 As 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Frandsen, Benjamin A.; Taddei, Keith M.; Yi, Ming

We report on temperature-dependent pair distribution function measurements of Sr 1-xNa xFe 2As 2, an iron-based superconductor system that contains a magnetic phase with reentrant tetragonal symmetry, known as the magnetic C 4 phase. Quantitative refinements indicate that the instantaneous local structure in the C 4 phase comprises fluctuating orthorhombic regions with a length scale of similar to 2 nm, despite the tetragonal symmetry of the average static structure. Additionally, local orthorhombic fluctuations exist on a similar length scale at temperatures well into the paramagnetic tetragonal phase. Furthermore, these results highlight the exceptionally large nematic susceptibility of iron-based superconductors andmore » have significant implications for the magnetic C 4 phase and the neighboring C 2 and superconducting phases.« less

Multi-phase-fluid discrimination with local fibre-optical probes: III. Three-phase flows

NASA Astrophysics Data System (ADS)

Fordham, E. J.; Ramos, R. T.; Holmes, A.; Simonian, S.; Huang, S.-M.; Lenn, C. P.

1999-12-01

Local fibre-optical sensors (or `local probes') for immiscible-fluid discrimination are demonstrated in three-phase (oil/water/gas) flows. The probes are made from standard silica fibres with plane oblique facets polished at the fibre tip, with surface treatment for wettability control. They use total internal reflection to distinguish among drops, bubbles and other regions of fluid in multi-phase flows, on the basis of refractive-index contrast. Dual probes, using two sensors each with a quasi-binary output, are used to determine profiles of three-phase volume fraction in a flow of kerosene, water and air in a pipe. The individual sensors used discriminate oil from `not-oil' and gas from liquid; their logical combination discriminates among the three phases. Companion papers deal with the sensor designs used and quantitative results achieved in the simpler two-phase cases of liquid/liquid flows and gas/liquid flows.

Dual-modality wide-field photothermal quantitative phase microscopy and depletion of cell populations

NASA Astrophysics Data System (ADS)

Turko, Nir A.; Barnea, Itay; Blum, Omry; Korenstein, Rafi; Shaked, Natan T.

2015-03-01

We review our dual-modality technique for quantitative imaging and selective depletion of populations of cells based on wide-field photothermal (PT) quantitative phase imaging and simultaneous PT cell extermination. The cells are first labeled by plasmonic gold nanoparticles, which evoke local plasmonic resonance when illuminated by light in a wavelength corresponding to their specific plasmonic resonance peak. This reaction creates changes of temperature, resulting in changes of phase. This phase changes are recorded by a quantitative phase microscope (QPM), producing specific imaging contrast, and enabling bio-labeling in phase microscopy. Using this technique, we have shown discrimination of EGFR over-expressing (EGFR+) cancer cells from EGFR under-expressing (EGFR-) cancer cells. Then, we have increased the excitation power in order to evoke greater temperatures, which caused specific cell death, all under real-time phase acquisition using QPM. Close to 100% of all EGFR+ cells were immediately exterminated when illuminated with the strong excitation beam, while all EGFR- cells survived. For the second experiment, in order to simulate a condition where circulating tumor cells (CTCs) are present in blood, we have mixed the EGFR+ cancer cells with white blood cells (WBCs) from a healthy donor. Here too, we have used QPM to observe and record the phase of the cells as they were excited for selective visualization and then exterminated. The WBCs survival rate was over 95%, while the EGFR+ survival rate was under 5%. The technique may be the basis for real-time detection and controlled treatment of CTCs.

A reversed-phase compatible thin-layer chromatography autography for the detection of acetylcholinesterase inhibitors.

PubMed

Ramallo, I Ayelen; García, Paula; Furlan, Ricardo L E

2015-11-01

A dual readout autographic assay to detect acetylcholinesterase inhibitors present in complex matrices adsorbed on reversed-phase or normal-phase thin-layer chromatography plates is described. Enzyme gel entrapment with an amphiphilic copolymer was used for assay development. The effects of substrate and enzyme concentrations, pH, incubation time, and incubation temperature on the sensitivity and the detection limit of the assay were evaluated. Experimental design and response surface methodology were used to optimize conditions with a minimum number of experiments. The assay allowed the detection of 0.01% w/w of physostigmine in both a spiked Sonchus oleraceus L. extract chromatographed on normal phase and a spiked Pimenta racemosa (Mill.) J.W. Moore leaf essential oil chromatographed on reversed phase. Finally, the reversed-phase thin-layer chromatography assay was applied to reveal the presence of an inhibitor in the Cymbopogon citratus (DC.) Stapf essential oil. The developed assay is able to detect acetylcholinesterase inhibitors present in complex matrixes that were chromatographed in normal phase or reversed-phase thin-layer chromatography. The detection limit for physostigmine on both normal and reversed phase was of 1×10(-4) μg. The results can be read by a change in color and/or a change in fluorescence. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Magnetic resonance imaging in stress fractures and shin splints.

PubMed

Aoki, Yoshimitsu; Yasuda, Kazunori; Tohyama, Harukazu; Ito, Hirokazu; Minami, Akio

2004-04-01

The purpose of the current study was to determine whether stress fractures and shin splints could be discriminated with MRI in the early phase. Twenty-two athletes, who had pain in the middle or distal part of their leg during or after sports activity, were evaluated with radiographs and MRI scans. Stress fractures were diagnosed when consecutive radiographs showed local periosteal reaction or a fracture line, and shin splints were diagnosed in all the other cases. In all eight patients with stress fractures, an abnormally wide high signal in the localized bone marrow was the most detectable in the coronal fat-suppressed MRI scan. In 11 patients with shin splints, the coronal fat-suppressed MRI scans showed a linear abnormally high signal along the medial posterior surface of the tibia, and in seven patients with shin splints, the MRI scans showed a linear abnormally high signal along the medial bone marrow. No MRI scans of shin splints showed an abnormally wide high signal in the bone marrow as observed on MRI scans of stress fractures. This study showed that fat-suppressed MRI is useful for discrimination between stress fracture and shin splints before radiographs show a detectable periosteal reaction in the tibia.

Detection of the mid-latitude Sporadic-E signal using GNSS/TEC and ALOS2 InSAR data

NASA Astrophysics Data System (ADS)

Suzuki, T.; Maeda, J.; Furuya, M.; Heki, K.

2016-12-01

Sporadic E (Es) is known to generate unusual propagation of VHF waves over long distances, which is caused by a layer of ionization that irregularly appears within the E region of the ionosphere. However, the generation mechanism of Es remains unclear, because the conventional ionosonde observation of Es has limited spatial resolution. Maeda et al. (2016) succeeded in capturing mid-latitude Es signal over Japan two-dimensionally as an image, using InSAR, and demonstrated the detailed spatial structure of Es. As InSAR is clearly useful for capturing Es, we aim to detect mid-latitude Es over Japan by InSAR, following Maeda et al. (2016). First, we chose the dates whose critical frequencies of Es (foEs) were more than 15MHz at ionosonde in Kokubunji, Wakkanai and Yamagawa in the morning and noon in 2016 from May to June; Es is known to be frequent in the local daytime of summer season. Secondly, we chose the ALOS-2/PALSAR-2 data sets whose observation area, dates and time matches the data above as closely as possible. Thirdly, we generated Global Navigation Satellite System - Total Electron Content (GNSS-TEC) map whose areas, dates and time become the same as the above and if Es appeared in GNSS-TEC map, we generate interferogram. We could detect interesting phase changes in the pair of February 17, 2016 (Master) and May 25, 2016 (Slave) along a track from Tottori to Okayama. The location of the phase shift is close to the Es on the GNSS-TEC image. Therefore, we can consider the phase shift as the edge of Es. This is the second successful detection of Es signals, using InSAR. Also, we are going to separate the Es signal from other non-dispersive signals, using split-band InSAR technique.

Ultra-low noise optical phase-locked loop

NASA Astrophysics Data System (ADS)

Ayotte, Simon; Babin, André; Costin, François

2014-03-01

The relative phase between two fiber lasers is controlled via a high performance optical phase-locked loop (OPLL). Two parameters are of particular importance for the design: the intrinsic phase noise of the laser (i.e. its linewidth) and a high-gain, low-noise electronic locking loop. In this work, one of the lowest phase noise fiber lasers commercially available was selected (i.e. NP Photonics Rock fiber laser module), with sub-kHz linewidth at 1550.12 nm. However, the fast tuning mechanism of such lasers is through stretching its cavity length with a piezoelectric transducer which has a few 10s kHz bandwidth. To further increase the locking loop bandwidth to several MHz, a second tuning mechanism is used by adding a Lithium Niobate phase modulator in the laser signal path. The OPLL is thus divided into two locking loops, a slow loop acting on the laser piezoelectric transducer and a fast loop acting on the phase modulator. The beat signal between the two phase-locked lasers yields a highly pure sine wave with an integrated phase error of 0.0012 rad. This is orders of magnitude lower than similar existing systems such as the Laser Synthesizer used for distribution of photonic local oscillator (LO) for the Atacama Large Millimeter Array radio telescope in Chile. Other applications for ultra-low noise OPLL include coherent power combining, Brillouin sensing, light detection and ranging (LIDAR), fiber optic gyroscopes, phased array antenna and beam steering, generation of LOs for next generation coherent communication systems, coherent analog optical links, terahertz generation and coherent spectroscopy.

Development and evaluation of an algorithm-based tool for Medication Management in nursing homes: the AMBER study protocol.

PubMed

Erzkamp, Susanne; Rose, Olaf

2018-04-20

Residents of nursing homes are susceptible to risks from medication. Medication Reviews (MR) can increase clinical outcomes and the quality of medication therapy. Limited resources and barriers between healthcare practitioners are potential obstructions to performing MR in nursing homes. Focusing on frequent and relevant problems can support pharmacists in the provision of pharmaceutical care services. This study aims to develop and evaluate an algorithm-based tool that facilitates the provision of Medication Management in clinical practice. This study is subdivided into three phases. In phase I, semistructured interviews with healthcare practitioners and patients will be performed, and a mixed methods approach will be chosen. Qualitative content analysis and the rating of the aspects concerning the frequency and relevance of problems in the medication process in nursing homes will be performed. In phase II, a systematic review of the current literature on problems and interventions will be conducted. The findings will be narratively presented. The results of both phases will be combined to develop an algorithm for MRs. For further refinement of the aspects detected, a Delphi survey will be conducted. In conclusion, a tool for clinical practice will be created. In phase III, the tool will be tested on MRs in nursing homes. In addition, effectiveness, acceptance, feasibility and reproducibility will be assessed. The primary outcome of phase III will be the reduction of drug-related problems (DRPs), which will be detected using the tool. The secondary outcomes will be the proportion of DRPs, the acceptance of pharmaceutical recommendations and the expenditure of time using the tool and inter-rater reliability. This study intervention is approved by the local Ethics Committee. The findings of the study will be presented at national and international scientific conferences and will be published in peer-reviewed journals. DRKS00010995. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Development and evaluation of an algorithm-based tool for Medication Management in nursing homes: the AMBER study protocol

PubMed Central

Rose, Olaf

2018-01-01

Background Residents of nursing homes are susceptible to risks from medication. Medication Reviews (MR) can increase clinical outcomes and the quality of medication therapy. Limited resources and barriers between healthcare practitioners are potential obstructions to performing MR in nursing homes. Focusing on frequent and relevant problems can support pharmacists in the provision of pharmaceutical care services. This study aims to develop and evaluate an algorithm-based tool that facilitates the provision of Medication Management in clinical practice. Methods and analysis This study is subdivided into three phases. In phase I, semistructured interviews with healthcare practitioners and patients will be performed, and a mixed methods approach will be chosen. Qualitative content analysis and the rating of the aspects concerning the frequency and relevance of problems in the medication process in nursing homes will be performed. In phase II, a systematic review of the current literature on problems and interventions will be conducted. The findings will be narratively presented. The results of both phases will be combined to develop an algorithm for MRs. For further refinement of the aspects detected, a Delphi survey will be conducted. In conclusion, a tool for clinical practice will be created. In phase III, the tool will be tested on MRs in nursing homes. In addition, effectiveness, acceptance, feasibility and reproducibility will be assessed. The primary outcome of phase III will be the reduction of drug-related problems (DRPs), which will be detected using the tool. The secondary outcomes will be the proportion of DRPs, the acceptance of pharmaceutical recommendations and the expenditure of time using the tool and inter-rater reliability. Ethics and dissemination This study intervention is approved by the local Ethics Committee. The findings of the study will be presented at national and international scientific conferences and will be published in peer-reviewed journals. Trial registration number DRKS00010995. PMID:29678967

A phase and frequency alignment protocol for 1H MRSI data of the prostate.

PubMed

Wright, Alan J; Buydens, Lutgarde M C; Heerschap, Arend

2012-05-01

(1)H MRSI of the prostate reveals relative metabolite levels that vary according to the presence or absence of tumour, providing a sensitive method for the identification of patients with cancer. Current interpretations of prostate data rely on quantification algorithms that fit model metabolite resonances to individual voxel spectra and calculate relative levels of metabolites, such as choline, creatine, citrate and polyamines. Statistical pattern recognition techniques can potentially improve the detection of prostate cancer, but these analyses are hampered by artefacts and sources of noise in the data, such as variations in phase and frequency of resonances. Phase and frequency variations may arise as a result of spatial field gradients or local physiological conditions affecting the frequency of resonances, in particular those of citrate. Thus, there are unique challenges in developing a peak alignment algorithm for these data. We have developed a frequency and phase correction algorithm for automatic alignment of the resonances in prostate MRSI spectra. We demonstrate, with a simulated dataset, that alignment can be achieved to a phase standard deviation of 0.095  rad and a frequency standard deviation of 0.68  Hz for the citrate resonances. Three parameters were used to assess the improvement in peak alignment in the MRSI data of five patients: the percentage of variance in all MRSI spectra explained by their first principal component; the signal-to-noise ratio of a spectrum formed by taking the median value of the entire set at each spectral point; and the mean cross-correlation between all pairs of spectra. These parameters showed a greater similarity between spectra in all five datasets and the simulated data, demonstrating improved alignment for phase and frequency in these spectra. This peak alignment program is expected to improve pattern recognition significantly, enabling accurate detection and localisation of prostate cancer with MRSI. Copyright © 2011 John Wiley & Sons, Ltd.

Fermi surface reconstruction and multiple quantum phase transitions in the antiferromagnet CeRhIn5

PubMed Central

Jiao, Lin; Chen, Ye; Kohama, Yoshimitsu; Graf, David; Bauer, E. D.; Singleton, John; Zhu, Jian-Xin; Weng, Zongfa; Pang, Guiming; Shang, Tian; Zhang, Jinglei; Lee, Han-Oh; Park, Tuson; Jaime, Marcelo; Thompson, J. D.; Steglich, Frank; Si, Qimiao; Yuan, H. Q.

2015-01-01

Conventional, thermally driven continuous phase transitions are described by universal critical behavior that is independent of the specific microscopic details of a material. However, many current studies focus on materials that exhibit quantum-driven continuous phase transitions (quantum critical points, or QCPs) at absolute zero temperature. The classification of such QCPs and the question of whether they show universal behavior remain open issues. Here we report measurements of heat capacity and de Haas–van Alphen (dHvA) oscillations at low temperatures across a field-induced antiferromagnetic QCP (Bc0 ≈ 50 T) in the heavy-fermion metal CeRhIn5. A sharp, magnetic-field-induced change in Fermi surface is detected both in the dHvA effect and Hall resistivity at B0* ≈ 30 T, well inside the antiferromagnetic phase. Comparisons with band-structure calculations and properties of isostructural CeCoIn5 suggest that the Fermi-surface change at B0* is associated with a localized-to-itinerant transition of the Ce-4f electrons in CeRhIn5. Taken in conjunction with pressure experiments, our results demonstrate that at least two distinct classes of QCP are observable in CeRhIn5, a significant step toward the derivation of a universal phase diagram for QCPs. PMID:25561536

A Local Quantum Phase Transition in YFe 2Al 10

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gannon, W J.; Zaliznyak, Igor A.; Wu, L. S.

Here, a phase transition occurs when correlated regions of a new phase grow to span the system and the fluctuations within the correlated regions become long-lived. Here we present neutron scattering measurements showing that this conventional picture must be replaced by a new paradigm in YFe 2Al 10, a compound that forms naturally very close to a T = 0 quantum phase transition. Fully quantum mechanical fluctuations of localized moments are found to diverge at low energies and temperatures, however the fluctuating moments are entirely without spatial correlations. Zero temperature order in YFe 2Al 10 is achieved by a newmore » and entirely local type of quantum phase transition that may originate with the creation of the moments themselves.« less

A Local Quantum Phase Transition in YFe 2Al 10

DOE PAGES

Gannon, W J.; Zaliznyak, Igor A.; Wu, L. S.; ...

2018-06-29

Here, a phase transition occurs when correlated regions of a new phase grow to span the system and the fluctuations within the correlated regions become long-lived. Here we present neutron scattering measurements showing that this conventional picture must be replaced by a new paradigm in YFe 2Al 10, a compound that forms naturally very close to a T = 0 quantum phase transition. Fully quantum mechanical fluctuations of localized moments are found to diverge at low energies and temperatures, however the fluctuating moments are entirely without spatial correlations. Zero temperature order in YFe 2Al 10 is achieved by a newmore » and entirely local type of quantum phase transition that may originate with the creation of the moments themselves.« less

Differentiating the growth phases of single bacteria using Raman spectroscopy

NASA Astrophysics Data System (ADS)

Strola, S. A.; Marcoux, P. R.; Schultz, E.; Perenon, R.; Simon, A.-C.; Espagnon, I.; Allier, C. P.; Dinten, J.-M.

2014-03-01

In this paper we present a longitudinal study of bacteria metabolism performed with a novel Raman spectrometer system. Longitudinal study is possible with our Raman setup since the overall procedure to localize a single bacterium and collect a Raman spectrum lasts only 1 minute. Localization and detection of single bacteria are performed by means of lensfree imaging, whereas Raman signal (from 600 to 3200 cm-1) is collected into a prototype spectrometer that allows high light throughput (HTVS technology, Tornado Spectral System). Accomplishing time-lapse Raman spectrometry during growth of bacteria, we observed variation in the net intensities for some band groups, e.g. amides and proteins. The obtained results on two different bacteria species, i.e. Escherichia coli and Bacillus subtilis clearly indicate that growth affects the Raman chemical signature. We performed a first analysis to check spectral differences and similarities. It allows distinguishing between lag, exponential and stationary growth phases. And the assignment of interest bands to vibration modes of covalent bonds enables the monitoring of metabolic changes in bacteria caused by growth and aging. Following the spectra analysis, a SVM (support vector machine) classification of the different growth phases is presented. In sum this longitudinal study by means of a compact and low-cost Raman setup is a proof of principle for routine analysis of bacteria, in a real-time and non-destructive way. Real-time Raman studies on metabolism and viability of bacteria pave the way for future antibiotic susceptibility testing.

Comparative Transcriptional Profiling of the Axolotl Limb Identifies a Tripartite Regeneration-Specific Gene Program

PubMed Central

Knapp, Dunja; Schulz, Herbert; Rascon, Cynthia Alexander; Volkmer, Michael; Scholz, Juliane; Nacu, Eugen; Le, Mu; Novozhilov, Sergey; Tazaki, Akira; Protze, Stephanie; Jacob, Tina; Hubner, Norbert; Habermann, Bianca; Tanaka, Elly M.

2013-01-01

Understanding how the limb blastema is established after the initial wound healing response is an important aspect of regeneration research. Here we performed parallel expression profile time courses of healing lateral wounds versus amputated limbs in axolotl. This comparison between wound healing and regeneration allowed us to identify amputation-specific genes. By clustering the expression profiles of these samples, we could detect three distinguishable phases of gene expression – early wound healing followed by a transition-phase leading to establishment of the limb development program, which correspond to the three phases of limb regeneration that had been defined by morphological criteria. By focusing on the transition-phase, we identified 93 strictly amputation-associated genes many of which are implicated in oxidative-stress response, chromatin modification, epithelial development or limb development. We further classified the genes based on whether they were or were not significantly expressed in the developing limb bud. The specific localization of 53 selected candidates within the blastema was investigated by in situ hybridization. In summary, we identified a set of genes that are expressed specifically during regeneration and are therefore, likely candidates for the regulation of blastema formation. PMID:23658691

Integrated ensemble noise-reconstructed empirical mode decomposition for mechanical fault detection

NASA Astrophysics Data System (ADS)

Yuan, Jing; Ji, Feng; Gao, Yuan; Zhu, Jun; Wei, Chenjun; Zhou, Yu

2018-05-01

A new branch of fault detection is utilizing the noise such as enhancing, adding or estimating the noise so as to improve the signal-to-noise ratio (SNR) and extract the fault signatures. Hereinto, ensemble noise-reconstructed empirical mode decomposition (ENEMD) is a novel noise utilization method to ameliorate the mode mixing and denoised the intrinsic mode functions (IMFs). Despite the possibility of superior performance in detecting weak and multiple faults, the method still suffers from the major problems of the user-defined parameter and the powerless capability for a high SNR case. Hence, integrated ensemble noise-reconstructed empirical mode decomposition is proposed to overcome the drawbacks, improved by two noise estimation techniques for different SNRs as well as the noise estimation strategy. Independent from the artificial setup, the noise estimation by the minimax thresholding is improved for a low SNR case, which especially shows an outstanding interpretation for signature enhancement. For approximating the weak noise precisely, the noise estimation by the local reconfiguration using singular value decomposition (SVD) is proposed for a high SNR case, which is particularly powerful for reducing the mode mixing. Thereinto, the sliding window for projecting the phase space is optimally designed by the correlation minimization. Meanwhile, the reasonable singular order for the local reconfiguration to estimate the noise is determined by the inflection point of the increment trend of normalized singular entropy. Furthermore, the noise estimation strategy, i.e. the selection approaches of the two estimation techniques along with the critical case, is developed and discussed for different SNRs by means of the possible noise-only IMF family. The method is validated by the repeatable simulations to demonstrate the synthetical performance and especially confirm the capability of noise estimation. Finally, the method is applied to detect the local wear fault from a dual-axis stabilized platform and the gear crack from an operating electric locomotive to verify its effectiveness and feasibility.

Scan statistics with local vote for target detection in distributed system

NASA Astrophysics Data System (ADS)

Luo, Junhai; Wu, Qi

2017-12-01

Target detection has occupied a pivotal position in distributed system. Scan statistics, as one of the most efficient detection methods, has been applied to a variety of anomaly detection problems and significantly improves the probability of detection. However, scan statistics cannot achieve the expected performance when the noise intensity is strong, or the signal emitted by the target is weak. The local vote algorithm can also achieve higher target detection rate. After the local vote, the counting rule is always adopted for decision fusion. The counting rule does not use the information about the contiguity of sensors but takes all sensors' data into consideration, which makes the result undesirable. In this paper, we propose a scan statistics with local vote (SSLV) method. This method combines scan statistics with local vote decision. Before scan statistics, each sensor executes local vote decision according to the data of its neighbors and its own. By combining the advantages of both, our method can obtain higher detection rate in low signal-to-noise ratio environment than the scan statistics. After the local vote decision, the distribution of sensors which have detected the target becomes more intensive. To make full use of local vote decision, we introduce a variable-step-parameter for the SSLV. It significantly shortens the scan period especially when the target is absent. Analysis and simulations are presented to demonstrate the performance of our method.

Classification of footwear outsole patterns using Fourier transform and local interest points.

PubMed

Richetelli, Nicole; Lee, Mackenzie C; Lasky, Carleen A; Gump, Madison E; Speir, Jacqueline A

2017-06-01

Successful classification of questioned footwear has tremendous evidentiary value; the result can minimize the potential suspect pool and link a suspect to a victim, a crime scene, or even multiple crime scenes to each other. With this in mind, several different automated and semi-automated classification models have been applied to the forensic footwear recognition problem, with superior performance commonly associated with two different approaches: correlation of image power (magnitude) or phase, and the use of local interest points transformed using the Scale Invariant Feature Transform (SIFT) and compared using Random Sample Consensus (RANSAC). Despite the distinction associated with each of these methods, all three have not been cross-compared using a single dataset, of limited quality (i.e., characteristic of crime scene-like imagery), and created using a wide combination of image inputs. To address this question, the research presented here examines the classification performance of the Fourier-Mellin transform (FMT), phase-only correlation (POC), and local interest points (transformed using SIFT and compared using RANSAC), as a function of inputs that include mixed media (blood and dust), transfer mechanisms (gel lifters), enhancement techniques (digital and chemical) and variations in print substrate (ceramic tiles, vinyl tiles and paper). Results indicate that POC outperforms both FMT and SIFT+RANSAC, regardless of image input (type, quality and totality), and that the difference in stochastic dominance detected for POC is significant across all image comparison scenarios evaluated in this study. Copyright © 2017 Elsevier B.V. All rights reserved.

InSAR-detected Local Ground Inflation Prior to Small Phreatic Eruption

NASA Astrophysics Data System (ADS)

Kobayashi, T.; Morishita, Y.

2017-12-01

Phreatic eruptions may be related to transient pressure changes in subsurface regions of hydrothermal systems. It means that crustal deformation presumably proceeds with the pressure increase under the ground, which can be a kind of precursor. In this context, Mt. Hakone volcano is a good study target. This is because the crustal deformation has been successfully detected two months before small phreatic eruptions at an active geothermal area, called Owaku-dani. The anomalous activity such as an increase of seismicity started in the end of April, 2015. With this anomalous activity, SAR (ALOS-2) observations was conducted, and small but significant crustal deformation was detected in a local area with a diameter of 200 m with a displacement of 5 cm. The amount of deformation has increased with time although the spatial size has not changed, and resultantly the amount reached up to 60 cm. Finally, in the end of June, eruptions occurred just at the local crustal deformation area. It should be noted that the eruption started from the InSAR-detected inflational area. This is an excellent case that we were able to identify the location of small phreatic eruption in advance by detecting anomalous ground inflation. Further, we investigated whether or not the inflational deformation preceded the anomalous activity observed since the end of April. Applying InSAR time series analysis incorporating the phase linking method to C-band SAR data of RADARSAT-2 (RS2) and Sentinel-1A (S1), we successfully detected small but significant inflational ground deformation that has already proceeded since the end of 2014 at the latest. The amount of deformation reaches up to 3 cm during 4 months. The most striking point is that the spatial distribution is quite similar to the deformation detected by ALOS-2. It strongly suggests that the pressure increase in subsurface have already started before the anomalous activities such as seismic swarm and widely-distributed deformation have been identified. Acknowledgements: ALOS-2 and RS2 data were provided from JAXA under a cooperative research contract between GSI and JAXA, and in addition, for RS2 under a contract between JAXA and CSA. The ownership of ALOS-2 and RS2 data belong to JAXA and MDA, respectively. This study was supported by JSPS KAKENHI Grant Numbers JP16K1779.

Delamination Detection Using Guided Wave Phased Arrays

NASA Technical Reports Server (NTRS)

Tian, Zhenhua; Yu, Lingyu; Leckey, Cara

2016-01-01

This paper presents a method for detecting multiple delaminations in composite laminates using non-contact phased arrays. The phased arrays are implemented with a non-contact scanning laser Doppler vibrometer (SLDV). The array imaging algorithm is performed in the frequency domain where both the guided wave dispersion effect and direction dependent wave properties are considered. By using the non-contact SLDV array with a frequency domain imaging algorithm, an intensity image of the composite plate can be generated for delamination detection. For the proof of concept, a laboratory test is performed using a non-contact phased array to detect two delaminations (created through quasi-static impact test) at different locations in a composite plate. Using the non-contact phased array and frequency domain imaging, the two impact-induced delaminations are successfully detected. This study shows that the non-contact phased array method is a potentially effective method for rapid delamination inspection in large composite structures.

Swept-source based, single-shot, multi-detectable velocity range Doppler optical coherence tomography

PubMed Central

Meemon, Panomsak; Rolland, Jannick P.

2010-01-01

Phase-Resolved Doppler Optical Coherence Tomography (PR-DOCT) allows visualization and characterization of the location, direction, velocity, and profile of flow activity embedded in a static sample structure. The detectable Velocity Dynamic Range (VDR) of each particular PR-DOCT system is governed by a detectable Doppler phase shift, a flow angle, and an acquisition time interval used to determine the Doppler phase shift. In general, the lower boundary of the detectable Doppler phase shift is limited by the phase stability of the system, while the upper boundary is limited by the π phase ambiguity. For a given range of detectable Doppler phase shift, shortening the acquisition duration will increase not only the maximum detectable velocity but unfortunately also the minimum detectable velocity, which may lead to the invisibility of a slow flow. In this paper, we present an alternative acquisition scheme for PR-DOCT that extends the lower limit of the velocity dynamic range, while maintaining the maximum detectable velocity, hence increasing the overall VDR of PR-DOCT system. The essence of the approach is to implement a technique of multi-scale measurement to simultaneously acquire multiple VDRs in a single measurement. We demonstrate an example of implementation of the technique in a dual VDR DOCT, where two Doppler maps having different detectable VDRs were simultaneously detected, processed, and displayed in real time. One was a fixed VDR DOCT capable of measuring axial velocity of up to 10.9 mm/s without phase unwrapping. The other was a variable VDR DOCT capable of adjusting its detectable VDR to reveal slow flow information down to 11.3 μm/s. The technique is shown to effectively extend the overall detectable VDR of the PR-DOCT system. Examples of real time Doppler imaging of an African frog tadpole are demonstrated using the dual-VDR DOCT system. PMID:21258521

Distortion of Local Atomic Structures in Amorphous Ge-Sb-Te Phase Change Materials

NASA Astrophysics Data System (ADS)

Hirata, A.; Ichitsubo, T.; Guan, P. F.; Fujita, T.; Chen, M. W.

2018-05-01

The local atomic structures of amorphous Ge-Sb-Te phase-change materials have yet to be clarified and the rapid crystal-amorphous phase change resulting in distinct optical contrast is not well understood. We report the direct observation of local atomic structures in amorphous Ge2Sb2Te5 using "local" reverse Monte Carlo modeling dedicated to an angstrom-beam electron diffraction analysis. The results corroborated the existence of local structures with rocksalt crystal-like topology that were greatly distorted compared to the crystal symmetry. This distortion resulted in the breaking of ideal octahedral atomic environments, thereby forming local disordered structures that basically satisfied the overall amorphous structure factor. The crystal-like distorted octahedral structures could be the main building blocks in the formation of the overall amorphous structure of Ge-Sb-Te.

Universal phase transition in community detectability under a stochastic block model.

PubMed

Chen, Pin-Yu; Hero, Alfred O

2015-03-01

We prove the existence of an asymptotic phase-transition threshold on community detectability for the spectral modularity method [M. E. J. Newman, Phys. Rev. E 74, 036104 (2006) and Proc. Natl. Acad. Sci. (USA) 103, 8577 (2006)] under a stochastic block model. The phase transition on community detectability occurs as the intercommunity edge connection probability p grows. This phase transition separates a subcritical regime of small p, where modularity-based community detection successfully identifies the communities, from a supercritical regime of large p where successful community detection is impossible. We show that, as the community sizes become large, the asymptotic phase-transition threshold p* is equal to √[p1p2], where pi(i=1,2) is the within-community edge connection probability. Thus the phase-transition threshold is universal in the sense that it does not depend on the ratio of community sizes. The universal phase-transition phenomenon is validated by simulations for moderately sized communities. Using the derived expression for the phase-transition threshold, we propose an empirical method for estimating this threshold from real-world data.

Quantitative shear wave optical coherence elastography (SW-OCE) with acoustic radiation force impulses (ARFI) induced by phase array transducer

NASA Astrophysics Data System (ADS)

Song, Shaozhen; Le, Nhan Minh; Wang, Ruikang K.; Huang, Zhihong

2015-03-01

Shear Wave Optical Coherence Elastography (SW-OCE) uses the speed of propagating shear waves to provide a quantitative measurement of localized shear modulus, making it a valuable technique for the elasticity characterization of tissues such as skin and ocular tissue. One of the main challenges in shear wave elastography is to induce a reliable source of shear wave; most of nowadays techniques use external vibrators which have several drawbacks such as limited wave propagation range and/or difficulties in non-invasive scans requiring precisions, accuracy. Thus, we propose linear phase array ultrasound transducer as a remote wave source, combined with the high-speed, 47,000-frame-per-second Shear-wave visualization provided by phase-sensitive OCT. In this study, we observed for the first time shear waves induced by a 128 element linear array ultrasound imaging transducer, while the ultrasound and OCT images (within the OCE detection range) were triggered simultaneously. Acoustic radiation force impulses are induced by emitting 10 MHz tone-bursts of sub-millisecond durations (between 50 μm - 100 μm). Ultrasound beam steering is achieved by programming appropriate phase delay, covering a lateral range of 10 mm and full OCT axial (depth) range in the imaging sample. Tissue-mimicking phantoms with agarose concentration of 0.5% and 1% was used in the SW-OCE measurements as the only imaging samples. The results show extensive improvements over the range of SW-OCE elasticity map; such improvements can also be seen over shear wave velocities in softer and stiffer phantoms, as well as determining the boundary of multiple inclusions with different stiffness. This approach opens up the feasibility to combine medical ultrasound imaging and SW-OCE for high-resolution localized quantitative measurement of tissue biomechanical property.

Phenotypic variation of Pseudomonas brassicacearum as a plant root-colonization strategy.

PubMed

Achouak, Wafa; Conrod, Sandrine; Cohen, Valérie; Heulin, Thierry

2004-08-01

Pseudomonas brassicacearum was isolated as a major root-colonizing population from Arabidopsis thaliana. The strain NFM421 of P. brassicacearum undergoes phenotypic variation during A. thaliana and Brassica napus root colonization in vitro as well as in soil, resulting in different colony appearance on agar surfaces. Bacteria forming translucent colonies (phase II cells) essentially were localized at the surface of young roots and root tips, whereas wild-type cells (phase I cells) were localized at the basal part of roots. The ability of phase II cells to spread and colonize new sites on root surface correlates with over-production of flagellin as evidenced by sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of surface proteins and microsequencing. Moreover, phase II cells showed a higher ability to swim and to swarm on semisolid agar medium. Phase I and phase II cells of P. brassicacearum NFM421 were tagged genetically with green fluorescent protein and red fluorescent protein. Confocal scanning laser microscopy was used to localize phase II cells on secondary roots and root tips of A. thaliana, whereas phase I cells essentially were localized at the basal part of roots. These experiments were conducted in vitro and in soil. Phenotypic variation on plant roots is likely to be a colonization strategy that may explain the high colonization power of P. brassicacearum.

Confronting Virginia's transportation challenge : phase II report of the Commission on Transportation in the Twenty-First Century

DOT National Transportation Integrated Search

1987-12-07

"In Phase II we have looked at transportation from a more local perspective. We have: 1. Examined the way local transportation financing needs can be met; 2. Looked at how state and local relations can be improved; and 3. Evaluated a variety of ways ...

Accoustic Localization of Breakdown in Radio Frequency Accelerating Cavities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lane, Peter Gwin

Current designs for muon accelerators require high-gradient radio frequency (RF) cavities to be placed in solenoidal magnetic fields. These fields help contain and efficiently reduce the phase space volume of source muons in order to create a usable muon beam for collider and neutrino experiments. In this context and in general, the use of RF cavities in strong magnetic fields has its challenges. It has been found that placing normal conducting RF cavities in strong magnetic fields reduces the threshold at which RF cavity breakdown occurs. To aid the effort to study RF cavity breakdown in magnetic fields, it wouldmore » be helpful to have a diagnostic tool which can localize the source of breakdown sparks inside the cavity. These sparks generate thermal shocks to small regions of the inner cavity wall that can be detected and localized using microphones attached to the outer cavity surface. Details on RF cavity sound sources as well as the hardware, software, and algorithms used to localize the source of sound emitted from breakdown thermal shocks are presented. In addition, results from simulations and experiments on three RF cavities, namely the Aluminum Mock Cavity, the High-Pressure Cavity, and the Modular Cavity, are also given. These results demonstrate the validity and effectiveness of the described technique for acoustic localization of breakdown.« less

Acoustic localization of breakdown in radio frequency accelerating cavities

NASA Astrophysics Data System (ADS)

Lane, Peter

Current designs for muon accelerators require high-gradient radio frequency (RF) cavities to be placed in solenoidal magnetic fields. These fields help contain and efficiently reduce the phase space volume of source muons in order to create a usable muon beam for collider and neutrino experiments. In this context and in general, the use of RF cavities in strong magnetic fields has its challenges. It has been found that placing normal conducting RF cavities in strong magnetic fields reduces the threshold at which RF cavity breakdown occurs. To aid the effort to study RF cavity breakdown in magnetic fields, it would be helpful to have a diagnostic tool which can localize the source of breakdown sparks inside the cavity. These sparks generate thermal shocks to small regions of the inner cavity wall that can be detected and localized using microphones attached to the outer cavity surface. Details on RF cavity sound sources as well as the hardware, software, and algorithms used to localize the source of sound emitted from breakdown thermal shocks are presented. In addition, results from simulations and experiments on three RF cavities, namely the Aluminum Mock Cavity, the High-Pressure Cavity, and the Modular Cavity, are also given. These results demonstrate the validity and effectiveness of the described technique for acoustic localization of breakdown.

Drude weight fluctuations in many-body localized systems

NASA Astrophysics Data System (ADS)

Filippone, Michele; Brouwer, Piet W.; Eisert, Jens; von Oppen, Felix

2016-11-01

We numerically investigate the distribution of Drude weights D of many-body states in disordered one-dimensional interacting electron systems across the transition to a many-body localized phase. Drude weights are proportional to the spectral curvatures induced by magnetic fluxes in mesoscopic rings. They offer a method to relate the transition to the many-body localized phase to transport properties. In the delocalized regime, we find that the Drude weight distribution at a fixed disorder configuration agrees well with the random-matrix-theory prediction P (D ) ∝(γ2+D2) -3 /2 , although the distribution width γ strongly fluctuates between disorder realizations. A crossover is observed towards a distribution with different large-D asymptotics deep in the many-body localized phase, which however differs from the commonly expected Cauchy distribution. We show that the average distribution width <γ >, rescaled by L Δ ,Δ being the average level spacing in the middle of the spectrum and L the systems size, is an efficient probe of the many-body localization transition, as it increases (vanishes) exponentially in the delocalized (localized) phase.

[Imaging of breast tumors using MR elastography].

PubMed

Lorenzen, J; Sinkus, R; Schrader, D; Lorenzen, M; Leussler, C; Dargatz, M; Röschmann, P

2001-01-01

Imaging of breast tumors using MR-Elastography. Low-frequency mechanical waves are transmitted into breast-tissue by means of an oscillator. The local characteristics of the mechanical wave are determined by the elastic properties of the tissue. By means of a motion-sensitive spin-echo-sequence these waves can be displayed within the phase of the MR image. Subsequently, these images can be used to reconstruct the local distribution of elasticity. In-vivo measurements were performed in 3 female patients with malignant tumors of the breast. All patients tolerated the measurement set-up without any untoward sensation in the contact area of skin and oszillator. The waves completely penetrated the breast, encompassing the axilla and regions close to the chest wall. All tumors were localized by MRE as structures of markedly stiffer tissue when compared to the surrounding tissue. Furthermore, in one patient, a metastasis in an axillary lymph node was detected. In all patients, local regions of increased elasticity were found in the remaining parenchyma of the breast, which, however, did not reach the high levels of elasticity found in the tumors. MRE is an imaging modality enabling adjunct tissue differentiation of mammary tumors.

Time-distance domain transformation for Acoustic Emission source localization in thin metallic plates.

PubMed

Grabowski, Krzysztof; Gawronski, Mateusz; Baran, Ireneusz; Spychalski, Wojciech; Staszewski, Wieslaw J; Uhl, Tadeusz; Kundu, Tribikram; Packo, Pawel

2016-05-01

Acoustic Emission used in Non-Destructive Testing is focused on analysis of elastic waves propagating in mechanical structures. Then any information carried by generated acoustic waves, further recorded by a set of transducers, allow to determine integrity of these structures. It is clear that material properties and geometry strongly impacts the result. In this paper a method for Acoustic Emission source localization in thin plates is presented. The approach is based on the Time-Distance Domain Transform, that is a wavenumber-frequency mapping technique for precise event localization. The major advantage of the technique is dispersion compensation through a phase-shifting of investigated waveforms in order to acquire the most accurate output, allowing for source-sensor distance estimation using a single transducer. The accuracy and robustness of the above process are also investigated. This includes the study of Young's modulus value and numerical parameters influence on damage detection. By merging the Time-Distance Domain Transform with an optimal distance selection technique, an identification-localization algorithm is achieved. The method is investigated analytically, numerically and experimentally. The latter involves both laboratory and large scale industrial tests. Copyright © 2016 Elsevier B.V. All rights reserved.

Local Response of Topological Order to an External Perturbation

NASA Astrophysics Data System (ADS)

Hamma, Alioscia; Cincio, Lukasz; Santra, Siddhartha; Zanardi, Paolo; Amico, Luigi

2013-05-01

We study the behavior of the Rényi entropies for the toric code subject to a variety of different perturbations, by means of 2D density matrix renormalization group and analytical methods. We find that Rényi entropies of different index α display derivatives with opposite sign, as opposed to typical symmetry breaking states, and can be detected on a very small subsystem regardless of the correlation length. This phenomenon is due to the presence in the phase of a point with flat entanglement spectrum, zero correlation length, and area law for the entanglement entropy. We argue that this kind of splitting is common to all the phases with a certain group theoretic structure, including quantum double models, cluster states, and other quantum spin liquids. The fact that the size of the subsystem does not need to scale with the correlation length makes it possible for this effect to be accessed experimentally.

In vivo optical elastography: stress and strain imaging of human skin lesions

NASA Astrophysics Data System (ADS)

Es'haghian, Shaghayegh; Gong, Peijun; Kennedy, Kelsey M.; Wijesinghe, Philip; Sampson, David D.; McLaughlin, Robert A.; Kennedy, Brendan F.

2015-03-01

Probing the mechanical properties of skin at high resolution could aid in the assessment of skin pathologies by, for example, detecting the extent of cancerous skin lesions and assessing pathology in burn scars. Here, we present two elastography techniques based on optical coherence tomography (OCT) to probe the local mechanical properties of skin. The first technique, optical palpation, is a high-resolution tactile imaging technique, which uses a complaint silicone layer positioned on the tissue surface to measure spatially-resolved stress imparted by compressive loading. We assess the performance of optical palpation, using a handheld imaging probe on a skin-mimicking phantom, and demonstrate its use on human skin. The second technique is a strain imaging technique, phase-sensitive compression OCE that maps depth-resolved mechanical variations within skin. We show preliminary results of in vivo phase-sensitive compression OCE on a human skin lesion.

A phase contrast imaging–interferometer system for detection of multiscale electron density fluctuations on DIII-D

DOE PAGES

Davis, E. M.; Rost, J. C.; Porkolab, M.; ...

2016-08-15

Heterodyne interferometry and phase contrast imaging (PCI) are robust, mature techniques for measuring low-k and high-k electron density fluctuations, respectively. Here, we describe the first-ever implementation of a combined PCI-interferometer. The combined system uses a single 10:6 μm probe beam, two interference schemes, and two detectors to measure electron density uctuations at large spatiotemporal bandwidth (10 kHz < f < 5MHz and 0 cm -1 ≤ k ≤ 20 cm -1), allowing simultaneous measurement of ion- and electron-scale instabilities. Further, correlating our interferometer's measurements with those from DIII-D's pre-existing, toroidally separated interferometer allows core-localized, low-n MHD studies that may otherwisemore » be inaccessible via external magnetic measurements. In the combined diagnostic's small port requirements and minimal access restrictions make it well-suited to the harsh neutron environments and limited port space expected in next-step devices.« less

[Symptomatic urinary tract infection of the female--diagnostics].

PubMed

Bruns, T; Piechota, H; Schneede, P

2006-04-01

The basis for the diagnostic work-up of recurrent cystitis is formed by taking a precise medical history against the background of knowledge of the pathogenesis of urinary tract infections. The anamnesis should also focus on factors that influence the natural flora (sexual intercourse, hygiene) but additionally include preceding antibiotic treatment and diseases that affect the immune status (diabetes mellitus). Urinalysis is the principal examination among the laboratory diagnostic procedures. The diagnosis is promptly confirmed by immediate analysis of a clean catch midstream urine sample using a counting chamber or a test strip. As a matter of principle, microbiological diagnosis always ensues. Extended diagnostic work-up (urological staging) is aimed at detecting functional and anatomic abnormalities. While these factors only play a subordinate role during the premenopausal phase, they gain in importance during the postmenopausal phase. A key role is also attributed to local estrogen deficiency.

A phase contrast imaging-interferometer system for detection of multiscale electron density fluctuations on DIII-D

NASA Astrophysics Data System (ADS)

Davis, E. M.; Rost, J. C.; Porkolab, M.; Marinoni, A.; Van Zeeland, M. A.

2016-11-01

Heterodyne interferometry and phase contrast imaging (PCI) are robust, mature techniques for measuring low-k and high-k electron density fluctuations, respectively. This work describes the first-ever implementation of a combined PCI-interferometer. The combined system uses a single 10.6 μm probe beam, two interference schemes, and two detectors to measure electron density fluctuations at large spatiotemporal bandwidth (10 kHz

Lattice dynamics and the nature of structural transitions in organolead halide perovskites

DOE PAGES

Comin, Riccardo; Crawford, Michael K.; Said, Ayman H.; ...

2016-09-09

Organolead halide perovskites are a family of hybrid organic-inorganic compounds whose remark- able optoelectronic properties have been under intensive scrutiny in recent years. Here we use inelastic X-ray scattering to study low-energy lattice excitations in single crystals of methylammonium lead iodide and bromide perovskites. Our ndings conrm the displacive nature of the cubic-to- tetragonal phase transition, which is further shown, using neutron and x-ray diraction, to be close to a tricritical point. The experimental sound speed, around 100-200 m/s, suggests that electron- phonon scattering is likely a limiting factor for further improvements in carrier mobility. Lastly, we detect quasistatic symmetry-breakingmore » nanodomains persisting well into the high-temperature cubic phase, possibly stabilized by local defects. These ndings reveal key structural properties of these materials, but also bear important implications for carrier dynamics across an extended temperature range relevant for photovoltaic applications.« less

The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication

PubMed Central

Aparicio, Tomás; Guillou, Emmanuelle; Coloma, Javier; Montoya, Guillermo; Méndez, Juan

2009-01-01

The GINS complex, originally discovered in Saccharomyces cerevisiae and Xenopus laevis, binds to DNA replication origins shortly before the onset of S phase and travels with the replication forks after initiation. In this study we present a detailed characterization of the human GINS (hGINS) homolog. Using new antibodies that allow the detection of endogenous hGINS in cells and tissues, we have examined its expression, abundance, subcellular localization and association with other DNA replication proteins. Expression of hGINS is restricted to actively proliferating cells. During the S phase, hGINS becomes part of a Cdc45–MCM–GINS (CMG) complex that is assembled on chromatin. Down-regulation of hGINS destabilizes CMG, causes a G1–S arrest and slows down ongoing DNA replication, effectively blocking cell proliferation. Our data support the notion that hGINS is an essential component of the human replisome. PMID:19223333

Lattice dynamics and the nature of structural transitions in organolead halide perovskites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Comin, Riccardo; Crawford, Michael K.; Said, Ayman H.

Organolead halide perovskites are a family of hybrid organic-inorganic compounds whose remark- able optoelectronic properties have been under intensive scrutiny in recent years. Here we use inelastic X-ray scattering to study low-energy lattice excitations in single crystals of methylammonium lead iodide and bromide perovskites. Our ndings conrm the displacive nature of the cubic-to- tetragonal phase transition, which is further shown, using neutron and x-ray diraction, to be close to a tricritical point. The experimental sound speed, around 100-200 m/s, suggests that electron- phonon scattering is likely a limiting factor for further improvements in carrier mobility. Lastly, we detect quasistatic symmetry-breakingmore » nanodomains persisting well into the high-temperature cubic phase, possibly stabilized by local defects. These ndings reveal key structural properties of these materials, but also bear important implications for carrier dynamics across an extended temperature range relevant for photovoltaic applications.« less

The Temporal Signature of Memories: Identification of a General Mechanism for Dynamic Memory Replay in Humans

PubMed Central

Michelmann, Sebastian; Bowman, Howard; Hanslmayr, Simon

2016-01-01

Reinstatement of dynamic memories requires the replay of neural patterns that unfold over time in a similar manner as during perception. However, little is known about the mechanisms that guide such a temporally structured replay in humans, because previous studies used either unsuitable methods or paradigms to address this question. Here, we overcome these limitations by developing a new analysis method to detect the replay of temporal patterns in a paradigm that requires participants to mentally replay short sound or video clips. We show that memory reinstatement is accompanied by a decrease of low-frequency (8 Hz) power, which carries a temporal phase signature of the replayed stimulus. These replay effects were evident in the visual as well as in the auditory domain and were localized to sensory-specific regions. These results suggest low-frequency phase to be a domain-general mechanism that orchestrates dynamic memory replay in humans. PMID:27494601

Evaluation of the capability of local helioseismology to discern between monolithic and spaghetti sunspot models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Felipe, T.; Crouch, A. D.; Birch, A. C., E-mail: tobias@nwra.com

2014-06-20

The helioseismic properties of the wave scattering generated by monolithic and spaghetti sunspots are analyzed by means of numerical simulations. In these computations, an incident f- or p {sub 1}-mode travels through the sunspot model, which produces absorption and phase shift of the waves. The scattering is studied by inspecting the wavefield, computing travel-time shifts, and performing Fourier-Hankel analysis. The comparison between the results obtained for both sunspot models reveals that the differences in the absorption coefficient can be detected above noise level. The spaghetti model produces a steep increase of the phase shift with the degree of the modemore » at short wavelengths, while mode mixing is more efficient for the monolithic model. These results provide a clue for what to look for in solar observations to discern the constitution of sunspots between the proposed monolithic and spaghetti models.« less

Resilient distributed control in the presence of misbehaving agents in networked control systems.

PubMed

Zeng, Wente; Chow, Mo-Yuen

2014-11-01

In this paper, we study the problem of reaching a consensus among all the agents in the networked control systems (NCS) in the presence of misbehaving agents. A reputation-based resilient distributed control algorithm is first proposed for the leader-follower consensus network. The proposed algorithm embeds a resilience mechanism that includes four phases (detection, mitigation, identification, and update), into the control process in a distributed manner. At each phase, every agent only uses local and one-hop neighbors' information to identify and isolate the misbehaving agents, and even compensate their effect on the system. We then extend the proposed algorithm to the leaderless consensus network by introducing and adding two recovery schemes (rollback and excitation recovery) into the current framework to guarantee the accurate convergence of the well-behaving agents in NCS. The effectiveness of the proposed method is demonstrated through case studies in multirobot formation control and wireless sensor networks.

Surface enhanced Raman scattering for detection of Pseudomonas aeruginosa quorum sensing compounds

NASA Astrophysics Data System (ADS)

Thrift, Will; Bhattacharjee, Arunima; Darvishzadeh-Varcheie, Mahsa; Lu, Ying; Hochbaum, Allon; Capolino, Filippo; Whiteson, Katrine; Ragan, Regina

2015-08-01

Pseudomonas aeruginosa (PA), a biofilm forming bacterium, commonly affects cystic fibrosis, burn victims, and immunocompromised patients. PA produces pyocyanin, an aromatic, redox active, secondary metabolite as part of its quorum sensing signaling system activated during biofilm formation. Surface enhanced Raman scattering (SERS) sensors composed of Au nanospheres chemically assembled into clusters on diblock copolymer templates were fabricated and the ability to detect pyocyanin to monitor biofilm formation was investigated. Electromagnetic full wave simulations of clusters observed in scanning electron microcopy images show that the localized surface plasmon resonance wavelength is 696 nm for a dimer with a gap spacing of 1 nm in an average dielectric environment of the polymer and analyte; the local electric field enhancement is on the order of 400 at resonance, relative to free space. SERS data acquired at 785 nm excitation from a monolayer of benzenethiol on fabricated samples was compared with Raman data of pure benzenethiol and enhancement factors as large as 8×109 were calculated that are consistent with simulated field enhancements. Using this system, the limit of detection of pyocyanin in pure gradients was determined to be 10 parts per billion. In SERS data of the supernatant from the time dependent growth of PA shaking cultures, pyocyanin vibrational modes were clearly observable during the logarithmic growth phase corresponding to activation of genes related to biofilm formation. These results pave the way for the use of SERS sensors for the early detection of biofilm formation, leading to reduced healthcare costs and better patient outcomes.

Selective Detection of Peptide-Oligonucleotide Heteroconjugates Utilizing Capillary HPLC-ICPMS

NASA Astrophysics Data System (ADS)

Catron, Brittany; Caruso, Joseph A.; Limbach, Patrick A.

2012-06-01

A method for the selective detection and quantification of peptide:oligonucleotide heteroconjugates, such as those generated by protein:nucleic acid cross-links, using capillary reversed-phase high performance liquid chromatography (cap-RPHPLC) coupled with inductively coupled plasma mass spectrometry detection (ICPMS) is described. The selective detection of phosphorus as 31P+, the only natural isotope, in peptide-oligonucleotide heteroconjugates is enabled by the elemental detection capabilities of the ICPMS. Mobile phase conditions that allow separation of heteroconjugates while maintaining ICPMS compatibility were investigated. We found that trifluoroacetic acid (TFA) mobile phases, used in conventional peptide separations, and hexafluoroisopropanol/triethylamine (HFIP/TEA) mobile phases, used in conventional oligonucleotide separations, both are compatible with ICPMS and enable heteroconjugate separation. The TFA-based separations yielded limits of detection (LOD) of ~40 ppb phosphorus, which is nearly seven times lower than the LOD for HFIP/TEA-based separations. Using the TFA mobile phase, 1-2 pmol of a model heteroconjugate were routinely separated and detected by this optimized capLC-ICPMS method.

The dynamics of error processing in the human brain as reflected by high-gamma activity in noninvasive and intracranial EEG.

PubMed

Völker, Martin; Fiederer, Lukas D J; Berberich, Sofie; Hammer, Jiří; Behncke, Joos; Kršek, Pavel; Tomášek, Martin; Marusič, Petr; Reinacher, Peter C; Coenen, Volker A; Helias, Moritz; Schulze-Bonhage, Andreas; Burgard, Wolfram; Ball, Tonio

2018-06-01

Error detection in motor behavior is a fundamental cognitive function heavily relying on local cortical information processing. Neural activity in the high-gamma frequency band (HGB) closely reflects such local cortical processing, but little is known about its role in error processing, particularly in the healthy human brain. Here we characterize the error-related response of the human brain based on data obtained with noninvasive EEG optimized for HGB mapping in 31 healthy subjects (15 females, 16 males), and additional intracranial EEG data from 9 epilepsy patients (4 females, 5 males). Our findings reveal a multiscale picture of the global and local dynamics of error-related HGB activity in the human brain. On the global level as reflected in the noninvasive EEG, the error-related response started with an early component dominated by anterior brain regions, followed by a shift to parietal regions, and a subsequent phase characterized by sustained parietal HGB activity. This phase lasted for more than 1 s after the error onset. On the local level reflected in the intracranial EEG, a cascade of both transient and sustained error-related responses involved an even more extended network, spanning beyond frontal and parietal regions to the insula and the hippocampus. HGB mapping appeared especially well suited to investigate late, sustained components of the error response, possibly linked to downstream functional stages such as error-related learning and behavioral adaptation. Our findings establish the basic spatio-temporal properties of HGB activity as a neural correlate of error processing, complementing traditional error-related potential studies. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Many-Body Localization and Thermalization in Quantum Statistical Mechanics

NASA Astrophysics Data System (ADS)

Nandkishore, Rahul; Huse, David A.

2015-03-01

We review some recent developments in the statistical mechanics of isolated quantum systems. We provide a brief introduction to quantum thermalization, paying particular attention to the eigenstate thermalization hypothesis (ETH) and the resulting single-eigenstate statistical mechanics. We then focus on a class of systems that fail to quantum thermalize and whose eigenstates violate the ETH: These are the many-body Anderson-localized systems; their long-time properties are not captured by the conventional ensembles of quantum statistical mechanics. These systems can forever locally remember information about their local initial conditions and are thus of interest for possibilities of storing quantum information. We discuss key features of many-body localization (MBL) and review a phenomenology of the MBL phase. Single-eigenstate statistical mechanics within the MBL phase reveal dynamically stable ordered phases, and phase transitions among them, that are invisible to equilibrium statistical mechanics and can occur at high energy and low spatial dimensionality, where equilibrium ordering is forbidden.

Some new reaction pathways for the formation of cytosine in interstellar space - A quantum chemical study

NASA Astrophysics Data System (ADS)

Gupta, V. P.; Tandon, Poonam; Mishra, Priti

2013-03-01

The detection of nucleic acid bases in carbonaceous meteorites suggests that their formation and survival is possible outside of the Earth. Small N-heterocycles, including pyrimidine, purines and nucleobases, have been extensively sought in the interstellar medium. It has been suggested theoretically that reactions between some interstellar molecules may lead to the formation of cytosine, uracil and thymine though these processes involve significantly high potential barriers. We attempted therefore to use quantum chemical techniques to explore if cytosine can possibly form in the interstellar space by radical-radical and radical-molecule interaction schemes, both in the gas phase and in the grains, through barrier-less or low barrier pathways. Results of DFT calculations for the formation of cytosine starting from some of the simple molecules and radicals detected in the interstellar space are being reported. Global and local descriptors such as molecular hardness, softness and electrophilicity, and condensed Fukui functions and local philicity indices were used to understand the mechanistic aspects of chemical reaction. The presence and nature of weak bonds in the molecules and transition states formed during the reaction process have been ascertained using Bader's quantum theory of atoms in molecules (QTAIMs). Two exothermic reaction pathways starting from propynylidyne (CCCH) and cyanoacetylene (HCCCN), respectively, have been identified. While the first reaction path is found to be totally exothermic, it involves a barrier of 12.5 kcal/mol in the gas phase against the lowest value of about 32 kcal/mol reported in the literature. The second path is both exothermic and barrier-less. The later has, therefore, a greater probability of occurrence in the cold interstellar clouds (10-50 K).

Molecular species forming at the α-Fe2O3 nanoparticle-aqueous solution interface.

PubMed

Ali, Hebatallah; Seidel, Robert; Pohl, Marvin N; Winter, Bernd

2018-05-21

We report on electronic structure measurements of the interface between hematite nanoparticles (6 nm diameter) and aqueous solutions. Using soft X-ray photoelectron spectroscopy from a liquid microjet we detect valence and core-level photoelectrons as well as Auger electrons from liquid water, from the nanoparticle-water interface, and from the interior of the aqueous-phase nanoparticles. Most noteworthy, the method is shown to be sufficiently sensitive for the detection of adsorbed hydroxyl species, resulting from H 2 O dissociation at the nanoparticle surface in aqueous solution. We obtain signal from surface OH from resonant, non-resonant, and from so-called partial-electron-yield X-ray absorption (PEY-XA) spectra. In addition, we report resonant photoelectron measurements at the iron 2p excitation. The respective Fe iron 2p 3/2 edge (L 3 -edge) PEY-XA spectra exhibit two main absorption peaks with their energies being sensitive to the chemical environment of the Fe 3+ ions at the nanoparticle-solution interface. This manifests in the 10 D q value which is a measure of the ligand-field strength. Furthermore, an observed intensity variation of the pre-peak, when comparing the PEY-XA spectra for different iron Auger-decay channels, can be assigned to different extents of electron delocalization. From the experimental fraction of local versus non-local autoionization signals we then find a very fast, approximately 1 fs, charge transfer time from interfacial Fe 3+ into the environment. The present study, which is complementary to ambient-pressure photoemission studies on solid-electrolyte systems, also highlights the multiple aspects of photoemission that need to be explored for a full characterization of the transition-metal-oxide nanoparticle surface in aqueous phase.

Atmospheric River Tracking Method Intercomparison Project (ARTMIP): Science Goals and Preliminary Analysis

NASA Astrophysics Data System (ADS)

Shields, C. A.; Rutz, J. J.; Wehner, M. F.; Ralph, F. M.; Leung, L. R.

2017-12-01

The Atmospheric River Tracking Method Intercomparison Project (ARTMIP) is a community effort whose purpose is to quantify uncertainties in atmospheric river (AR) research solely due to different identification and tracking techniques. Atmospheric rivers transport significant amounts of moisture in long, narrow filamentary bands, typically travelling from the subtropics to the mid-latitudes. They are an important source of regional precipitation impacting local hydroclimate, and in extreme cases, cause severe flooding and infrastructure damage in local communities. Our understanding of ARs, from forecast skill to future climate projections, all hinge on how we define ARs. By comparing a diverse set of detection algorithms, the uncertainty in our definition of ARs, (including statistics and climatology), and the implications of those uncertainties, can be analyzed and quantified. ARTMIP is divided into two broad phases that aim to answer science questions impacted by choice of detection algorithm. How robust are AR metrics such as climatology, storm duration, and relationship to extreme precipitation? How are the AR metrics in future climate projections impacted by choice of algorithm? Some algorithms rely on threshold values for water vapor. In a warmer world, the background state, by definition, is moister due to the Clausius-Clapeyron relationship, and could potentially skew results. Can uncertainty bounds be accurately placed on each metric? Tier 1 participants will apply their algorithms to a high resolution common dataset (MERRA2) and provide the greater group AR metrics (frequency, location, duration, etc). Tier 2 research will encompass sensitivity studies regarding resolution, reanalysis choice, and future climate change scenarios. ARTMIP is currently in the Tier 1 Phase and will begin Tier 2 in 2018. Preliminary metrics and analysis from Tier 1 will be presented.

GREEN BANK TELESCOPE DETECTION OF POLARIZATION-DEPENDENT H I ABSORPTION AND H I OUTFLOWS IN LOCAL ULIRGs AND QUASARS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Teng, Stacy H.; Veilleux, Sylvain; Baker, Andrew J., E-mail: stacy.h.teng@nasa.gov

2013-03-10

We present the results of a 21 cm H I survey of 27 local massive gas-rich late-stage mergers and merger remnants with the Robert C. Byrd Green Bank Telescope. These remnants were selected from the Quasar/ULIRG Evolution Study sample of ultraluminous infrared galaxies (ULIRGs; L{sub 8{sub -{sub 1000{sub {mu}m}}}} > 10{sup 12} L{sub Sun }) and quasars; our targets are all bolometrically dominated by active galactic nuclei (AGNs) and sample the later phases of the proposed ULIRG-to-quasar evolutionary sequence. We find the prevalence of H I absorption (emission) to be 100% (29%) in ULIRGs with H I detections, 100% (88%)more » in FIR-strong quasars, and 63% (100%) in FIR-weak quasars. The absorption features are associated with powerful neutral outflows that change from being mainly driven by star formation in ULIRGs to being driven by the AGN in the quasars. These outflows have velocities that exceed 1500 km s{sup -1} in some cases. Unexpectedly, we find polarization-dependent H I absorption in 57% of our spectra (88% and 63% of the FIR-strong and FIR-weak quasars, respectively). We attribute this result to absorption of polarized continuum emission from these sources by foreground H I clouds. About 60% of the quasars displaying polarized spectra are radio-loud, far higher than the {approx}10% observed in the general AGN population. This discrepancy suggests that radio jets play an important role in shaping the environments in these galaxies. These systems may represent a transition phase in the evolution of gas-rich mergers into ''mature'' radio galaxies.« less

Echogenicity based approach to detect, segment and track the common carotid artery in 2D ultrasound images.

PubMed

Narayan, Nikhil S; Marziliano, Pina

2015-08-01

Automatic detection and segmentation of the common carotid artery in transverse ultrasound (US) images of the thyroid gland play a vital role in the success of US guided intervention procedures. We propose in this paper a novel method to accurately detect, segment and track the carotid in 2D and 2D+t US images of the thyroid gland using concepts based on tissue echogenicity and ultrasound image formation. We first segment the hypoechoic anatomical regions of interest using local phase and energy in the input image. We then make use of a Hessian based blob like analysis to detect the carotid within the segmented hypoechoic regions. The carotid artery is segmented by making use of least squares ellipse fit for the edge points around the detected carotid candidate. Experiments performed on a multivendor dataset of 41 images show that the proposed algorithm can segment the carotid artery with high sensitivity (99.6 ±m 0.2%) and specificity (92.9 ±m 0.1%). Further experiments on a public database containing 971 images of the carotid artery showed that the proposed algorithm can achieve a detection accuracy of 95.2% with a 2% increase in performance when compared to the state-of-the-art method.

Optical Phase Recovery and Locking in a PPM Laser Communication Link

NASA Technical Reports Server (NTRS)

Aveline, David C.; Yu, Nan; Farr, William H.

2012-01-01

Free-space optical communication holds great promise for future space missions requiring high data rates. For data communication in deep space, the current architecture employs pulse position modulation (PPM). In this scheme, the light is transmitted and detected as pulses within an array of time slots. While the PPM method is efficient for data transmission, the phase of the laser light is not utilized. The phase coherence of a PPM optical signal has been investigated with the goal of developing a new laser communication and ranging scheme that utilizes optical coherence within the established PPM architecture and photon-counting detection (PCD). Experimental measurements of a PPM modulated optical signal were conducted, and modeling code was developed to generate random PPM signals and simulate spectra via FFT (Fast Fourier Transform) analysis. The experimental results show very good agreement with the simulations and confirm that coherence is preserved despite modulation with high extinction ratios and very low duty cycles. A real-time technique has been developed to recover the phase information through the mixing of a PPM signal with a frequency-shifted local oscillator (LO). This mixed signal is amplified, filtered, and integrated to generate a voltage proportional to the phase of the modulated signal. By choosing an appropriate time constant for integration, one can maintain a phase lock despite long dark times between consecutive pulses with low duty cycle. A proof-of-principle demonstration was first achieved with an RF-based PPM signal and test setup. With the same principle method, an optical carrier within a PPM modulated laser beam could also be tracked and recovered. A reference laser was phase-locked to an independent pulsed laser signal with low-duty-cycle pseudo-random PPM codes. In this way, the drifting carrier frequency in the primary laser source is tracked via its phase change in the mixed beat note, while the corresponding voltage feedback maintains the phase lock between the two laser sources. The novelty and key significance of this work is that the carrier phase information can be harnessed within an optical communication link based on PPM-PCD architecture. This technology development could lead to quantum-limited efficient performance within the communication link itself, as well as enable high-resolution optical tracking capabilities for planetary science and spacecraft navigation.

All optical coherent receiver for self-homodyne detection of digitally phase modulated optical signals

NASA Astrophysics Data System (ADS)

Kiasaleh, Kamran

1994-02-01

A novel optical phase-locked loop (OPLL) system for the self-homodyne detection of digitally phase modulated optical signals is introduced. A Mach-Zehnder type interferometer is used to self-homodyne binary phase-modulated optical signals with an external phase modulator inserted in the control arm of the interferometer.

Coherent Optical Adaptive Techniques (COAT)

DTIC Science & Technology

1975-01-01

8217 neceeemry and Identity by block number) Laser Phased Array Adaptive Optics Atmospheric-Turbulence and Thermal Blooming Compensation 20...characteristics of an experimental, visible wavelength, eighteen-element, self-adaptive optical phased array. Measurements on a well-characterized...V LOCAL PHASING ■ LOOP OPTICAL DETECTOR’ LOCAL LOCK / ROOF TOP "^/PROPAGATION’ ^ GLINT ■lm FOCAL LENGTH LENS DETECTOR DMWI rh

Collective odor source estimation and search in time-variant airflow environments using mobile robots.

PubMed

Meng, Qing-Hao; Yang, Wei-Xing; Wang, Yang; Zeng, Ming

2011-01-01

This paper addresses the collective odor source localization (OSL) problem in a time-varying airflow environment using mobile robots. A novel OSL methodology which combines odor-source probability estimation and multiple robots' search is proposed. The estimation phase consists of two steps: firstly, the separate probability-distribution map of odor source is estimated via Bayesian rules and fuzzy inference based on a single robot's detection events; secondly, the separate maps estimated by different robots at different times are fused into a combined map by way of distance based superposition. The multi-robot search behaviors are coordinated via a particle swarm optimization algorithm, where the estimated odor-source probability distribution is used to express the fitness functions. In the process of OSL, the estimation phase provides the prior knowledge for the searching while the searching verifies the estimation results, and both phases are implemented iteratively. The results of simulations for large-scale advection-diffusion plume environments and experiments using real robots in an indoor airflow environment validate the feasibility and robustness of the proposed OSL method.

Collective Odor Source Estimation and Search in Time-Variant Airflow Environments Using Mobile Robots

PubMed Central

Meng, Qing-Hao; Yang, Wei-Xing; Wang, Yang; Zeng, Ming

2011-01-01

This paper addresses the collective odor source localization (OSL) problem in a time-varying airflow environment using mobile robots. A novel OSL methodology which combines odor-source probability estimation and multiple robots’ search is proposed. The estimation phase consists of two steps: firstly, the separate probability-distribution map of odor source is estimated via Bayesian rules and fuzzy inference based on a single robot’s detection events; secondly, the separate maps estimated by different robots at different times are fused into a combined map by way of distance based superposition. The multi-robot search behaviors are coordinated via a particle swarm optimization algorithm, where the estimated odor-source probability distribution is used to express the fitness functions. In the process of OSL, the estimation phase provides the prior knowledge for the searching while the searching verifies the estimation results, and both phases are implemented iteratively. The results of simulations for large-scale advection–diffusion plume environments and experiments using real robots in an indoor airflow environment validate the feasibility and robustness of the proposed OSL method. PMID:22346650

Five-year trends of selected halogenated flame retardants in the atmosphere of Northeast China.

PubMed

Li, Wen-Long; Liu, Li-Yan; Song, Wei-Wei; Zhang, Zi-Feng; Qiao, Li-Na; Ma, Wan-Li; Li, Yi-Fan

2016-01-01

This study collected 227 pairs of gas phase and particle phase air samples in a typical urban city of Northeast China from 2008 to 2013. Four alternative halogenated flame retardants for polybrominated diphenyl ethers (PBDEs) were analyzed, namely 2-ethylhexyl 2,3,4,5-tetrabromobenzoate (EHTBB), bis (2-ethylhexyl) tetrabromophthalate (BEHTBP), syn-dechlorane plus (syn-DP) and anti-dechlorane plus (anti-DP). The average concentrations for EHTBB and BEHTBP were 5.2 ± 20 and 30 ± 200 pg/m3, respectively, while for syn-DP and anti-DPwere 1.9±5.1 and 5.8±18 pg/m3, respectively. Generally, they were frequently detected in the particle phase, and the gas/particle partitioning suggested they were the maximum partition chemicals. The fractional abundance of EHTBB (fEHTBB) and syn-DP (fsyn)were comparablewith those in other studies. Strong local sources were identified based on the air parcel backward trajectories and the potential source contribution function. The concentrations of these chemicals were significantly increased during this sampling campaign, possibly suggesting their increasing usages from 2008 to 2013 in China.

A source study of atmospheric polycyclic aromatic hydrocarbons in Shenzhen, South China.

PubMed

Liu, Guoqing; Tong, Yongpeng; Luong, John H T; Zhang, Hong; Sun, Huibin

2010-04-01

Air pollution has become a serious problem in the Pearl River Delta, South China, particularly in winter due to the local micrometeorology. In this study, atmospheric polycyclic aromatic hydrocarbons (PAHs) were monitored weekly in Shenzhen during the winter of 2006. Results indicated that the detected PAHs were mainly of vapor phase compounds with phenanthrene dominant. The average vapor phase and particle phase PAHs concentration in Shenzhen was 101.3 and 26.7 ng m( - 3), respectively. Meteorological conditions showed great effect on PAH concentrations. The higher PAHs concentrations observed during haze episode might result from the accumulation of pollutants under decreased boundary layer, slower wind speed, and long-term dryness conditions. The sources of PAHs in the air were estimated by principal component analysis in combination with diagnostic ratios. Vehicle exhaust was the major PAHs source in Shenzhen, accounting for 50.0% of the total PAHs emissions, whereas coal combustion and solid waste incineration contributed to 29.4% and 20.6% of the total PAHs concentration, respectively. The results clearly indicated that the increasing solid waste incinerators have become a new important PAHs source in this region.

Phase I Trial of Adenovirus-Mediated IL-12 Gene Transduction in Patients with Recurrent Locally Advanced Prostate Cancer Following Therapy

DTIC Science & Technology

2005-10-01

salvage seed implant, cryotherapy ) or who have a rising PSA while on hormone therapy for locally advanced prostate cancer are as follows: a. A...Gene Transduction in Patients with Recurrent Locally Advanced Prostate Cancer Following Therapy PRINCIPAL INVESTIGATOR: Simon J. Hall, MD...CONTRACT NUMBER Phase I Trial of Adenovirus-Mediated IL-12 Gene Transduction in Patients with Recurrent Locally Advanced Prostate Cancer Following

A semi-Markov model for mitosis segmentation in time-lapse phase contrast microscopy image sequences of stem cell populations.

PubMed

Liu, An-An; Li, Kang; Kanade, Takeo

2012-02-01

We propose a semi-Markov model trained in a max-margin learning framework for mitosis event segmentation in large-scale time-lapse phase contrast microscopy image sequences of stem cell populations. Our method consists of three steps. First, we apply a constrained optimization based microscopy image segmentation method that exploits phase contrast optics to extract candidate subsequences in the input image sequence that contains mitosis events. Then, we apply a max-margin hidden conditional random field (MM-HCRF) classifier learned from human-annotated mitotic and nonmitotic sequences to classify each candidate subsequence as a mitosis or not. Finally, a max-margin semi-Markov model (MM-SMM) trained on manually-segmented mitotic sequences is utilized to reinforce the mitosis classification results, and to further segment each mitosis into four predefined temporal stages. The proposed method outperforms the event-detection CRF model recently reported by Huh as well as several other competing methods in very challenging image sequences of multipolar-shaped C3H10T1/2 mesenchymal stem cells. For mitosis detection, an overall precision of 95.8% and a recall of 88.1% were achieved. For mitosis segmentation, the mean and standard deviation for the localization errors of the start and end points of all mitosis stages were well below 1 and 2 frames, respectively. In particular, an overall temporal location error of 0.73 ± 1.29 frames was achieved for locating daughter cell birth events.

Improved detection sensitivity of D-mannitol crystalline phase content using differential spectral phase shift terahertz spectroscopy measurements.

PubMed

Allard, Jean-François; Cornet, Alain; Debacq, Christophe; Meurens, Marc; Houde, Daniel; Morris, Denis

2011-02-28

We report quantitative measurement of the relative proportion of δ- and β-D-mannitol crystalline phases inserted into polyethylene powder pellets, obtained by time-domain terahertz spectroscopy. Nine absorption bands have been identified from 0.2 THz to 2.2 THz. The best quantification of the δ-phase proportion is made using the 1.01 THz absorption band. Coherent detection allows using the spectral phase shift of the transmitted THz waveform to improve the detection sensitivity of the relative δ-phase proportion. We argue that differential phase shift measurements are less sensitive to samples' defects. Using a linear phase shift compensation for pellets of slightly different thicknesses, we were able to distinguish a 0.5% variation in δ-phase proportion.

Detection of entanglement with few local measurements

NASA Astrophysics Data System (ADS)

Gühne, O.; Hyllus, P.; Bruß, D.; Ekert, A.; Lewenstein, M.; Macchiavello, C.; Sanpera, A.

2002-12-01

We introduce a general method for the experimental detection of entanglement by performing only few local measurements, assuming some prior knowledge of the density matrix. The idea is based on the minimal decomposition of witness operators into a pseudomixture of local operators. We discuss an experimentally relevant case of two qubits, and show an example how bound entanglement can be detected with few local measurements.

Classical impurities and boundary Majorana zero modes in quantum chains

NASA Astrophysics Data System (ADS)

Müller, Markus; Nersesyan, Alexander A.

2016-09-01

We study the response of classical impurities in quantum Ising chains. The Z2 degeneracy they entail renders the existence of two decoupled Majorana modes at zero energy, an exact property of a finite system at arbitrary values of its bulk parameters. We trace the evolution of these modes across the transition from the disordered phase to the ordered one and analyze the concomitant qualitative changes of local magnetic properties of an isolated impurity. In the disordered phase, the two ground states differ only close to the impurity, and they are related by the action of an explicitly constructed quasi-local operator. In this phase the local transverse spin susceptibility follows a Curie law. The critical response of a boundary impurity is logarithmically divergent and maps to the two-channel Kondo problem, while it saturates for critical bulk impurities, as well as in the ordered phase. The results for the Ising chain translate to the related problem of a resonant level coupled to a 1d p-wave superconductor or a Peierls chain, whereby the magnetic order is mapped to topological order. We find that the topological phase always exhibits a continuous impurity response to local fields as a result of the level repulsion of local levels from the boundary Majorana zero mode. In contrast, the disordered phase generically features a discontinuous magnetization or charging response. This difference constitutes a general thermodynamic fingerprint of topological order in phases with a bulk gap.

Chimera states and the interplay between initial conditions and non-local coupling

NASA Astrophysics Data System (ADS)

Kalle, Peter; Sawicki, Jakub; Zakharova, Anna; Schöll, Eckehard

2017-03-01

Chimera states are complex spatio-temporal patterns that consist of coexisting domains of coherent and incoherent dynamics. We study chimera states in a network of non-locally coupled Stuart-Landau oscillators. We investigate the impact of initial conditions in combination with non-local coupling. Based on an analytical argument, we show how the coupling phase and the coupling strength are linked to the occurrence of chimera states, flipped profiles of the mean phase velocity, and the transition from a phase- to an amplitude-mediated chimera state.

Chimera states and the interplay between initial conditions and non-local coupling.

PubMed

Kalle, Peter; Sawicki, Jakub; Zakharova, Anna; Schöll, Eckehard

2017-03-01

Chimera states are complex spatio-temporal patterns that consist of coexisting domains of coherent and incoherent dynamics. We study chimera states in a network of non-locally coupled Stuart-Landau oscillators. We investigate the impact of initial conditions in combination with non-local coupling. Based on an analytical argument, we show how the coupling phase and the coupling strength are linked to the occurrence of chimera states, flipped profiles of the mean phase velocity, and the transition from a phase- to an amplitude-mediated chimera state.

Amplitude-phase cross talk as a deterioration factor of signal-to-noise ratio in phase-detection noise-cancellation technique for spectral pump/probe measurements and compensation of the amplitude-phase cross talk

NASA Astrophysics Data System (ADS)

Seto, Keisuke; Tarumi, Takashi; Tokunaga, Eiji

2018-06-01

Noise cancellation of the light source is an important method to enhance the signal-to-noise ratio (SNR) and facilitate high-speed detection in pump/probe measurements. We developed a method to eliminate the noise for the multichannel spectral pump/probe measurements with a spectral dispersion of a white probe pulse light. In this method, the sample-induced intensity modulation is converted to the phase modulation of the pulse repetition irrespective of the intensity noise of the light source. The SNR is enhanced through the phase detection of the observed signal with the signal synchronized to the pulse repetition serving as the phase reference (synchronized signal). However, the shot-noise limited performance is not achieved with an intense probe light. In this work, we demonstrate that the performance limitation below the shot noise limit is caused by the amplitude-phase cross talk. It converts the amplitude noise into the phase noise and is caused by the space-charge effect in the photodetector, the reverse bias voltage drop across the load impedance, and the phase detection circuit. The phase delay occurs with an intense light at a PIN photodiode, whereas the phase is advanced in an avalanche photodiode. Although the amplitude distortion characteristics also reduce the performance, the distortion effect is equivalent to the amplitude-phase cross talk. We also propose possible ways to compensate the cross talk effect by using the phase modulation of the synchronized signal for the phase detection based on the instantaneous amplitude.

Phase synchronization based on a Dual-Tree Complex Wavelet Transform

NASA Astrophysics Data System (ADS)

Ferreira, Maria Teodora; Domingues, Margarete Oliveira; Macau, Elbert E. N.

2016-11-01

In this work, we show the applicability of our Discrete Complex Wavelet Approach (DCWA) to verify the phenomenon of phase synchronization transition in two coupled chaotic Lorenz systems. DCWA is based on the phase assignment from complex wavelet coefficients obtained by using a Dual-Tree Complex Wavelet Transform (DT-CWT). We analyzed two coupled chaotic Lorenz systems, aiming to detect the transition from non-phase synchronization to phase synchronization. In addition, we check how good is the method in detecting periods of 2π phase-slips. In all experiments, DCWA is compared with classical phase detection methods such as the ones based on arctangent and Hilbert transform showing a much better performance.